Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NFE2L3	9603	broad.mit.edu	37	7	26224503	26224503	+	Missense_Mutation	SNP	G	G	T			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr7:26224503G>T	uc003sxq.3	+	3	1457	c.1185G>T	c.(1183-1185)atG>atT	p.M395I		NM_004289	NP_004280	Q9Y4A8	NF2L3_HUMAN	Homo sapiens nuclear factor (erythroid-derived 2)-like 3 (NFE2L3), mRNA.	395					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)|endometrium(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)|skin(5)|urinary_tract(7)	29						TAAACTTAATGTCATTGGCCA	0.363000													24	41					7.41945e-09	7.72105e-09	1	1	0
DAG1	1605	broad.mit.edu	37	3	49568609	49568609	+	Missense_Mutation	SNP	T	T	C			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr3:49568609T>C	uc021wxz.1	+	2	1134	c.665T>C	c.(664-666)cTt>cCt	p.L222P	DAG1_uc021wya.1_Missense_Mutation_p.L222P|DAG1_uc021wyb.1_Missense_Mutation_p.L222P|DAG1_uc021wyc.1_Missense_Mutation_p.L222P|DAG1_uc021wyd.1_Missense_Mutation_p.L222P|DAG1_uc021wye.1_Missense_Mutation_p.L222P|DAG1_uc021wyf.1_Missense_Mutation_p.L222P|DAG1_uc021wyg.1_Missense_Mutation_p.L222P|DAG1_uc021wyh.1_Missense_Mutation_p.L222P|DAG1_uc021wyi.1_Missense_Mutation_p.L222P|DAG1_uc021wyj.1_Missense_Mutation_p.L222P|DAG1_uc021wyk.1_Missense_Mutation_p.L222P|DAG1_uc003cxc.4_Missense_Mutation_p.L222P	NM_001177643	NP_001171114	Q14118	DAG1_HUMAN	Homo sapiens dystroglycan 1 (dystrophin-associated glycoprotein 1) (DAG1), transcript variant 12, mRNA.	222	Required for laminin recognition.				cytoskeletal anchoring at plasma membrane|interspecies interaction between organisms|microtubule anchoring|negative regulation of MAPKKK cascade|negative regulation of cell migration|negative regulation of protein kinase B signaling cascade	basement membrane|contractile ring|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|extracellular space|filopodium|integral to membrane|integral to membrane of membrane fraction|lamellipodium|nucleoplasm	actin binding|alpha-actinin binding|calcium ion binding|laminin-1 binding|receptor activity|structural constituent of muscle|tubulin binding|vinculin binding			NS(1)|autonomic_ganglia(2)|breast(2)|endometrium(1)|large_intestine(8)|lung(5)|ovary(2)|prostate(1)|skin(1)	23				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.00241)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		GAAGTAGAGCTTCACAACATG	0.493000													41	58					0	0	1	0	0
ABHD10	55347	broad.mit.edu	37	3	111710242	111710242	+	Missense_Mutation	SNP	A	A	C			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr3:111710242A>C	uc003dyk.4	+	4	676	c.595A>C	c.(595-597)Atg>Ctg	p.M199L	ABHD10_uc011bhq.2_Missense_Mutation_p.M42L	NM_018394	NP_060864	Q9NUJ1	ABHDA_HUMAN	Homo sapiens abhydrolase domain containing 10 (ABHD10), mRNA.	199						mitochondrion	serine-type peptidase activity			large_intestine(2)|lung(7)|skin(1)	10						GGAAGTAGAGATGAAAGGTGT	0.323000													26	103					0	0	1	0	0
ARHGAP21	57584	broad.mit.edu	37	10	24873742	24873742	+	Missense_Mutation	SNP	C	C	T			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr10:24873742C>T	uc001isb.2	-	25	5963	c.5476G>A	c.(5476-5478)Ggg>Agg	p.G1826R	ARHGAP21_uc010qdb.1_Non-coding_Transcript	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Homo sapiens Rho GTPase activating protein 21 (ARHGAP21), mRNA.	1825	Interaction with CTNNA1.				signal transduction	Golgi membrane|cell junction|cytoplasmic vesicle membrane|cytoskeleton	GTPase activator activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(4)|large_intestine(17)|lung(21)|ovary(7)|pancreas(1)|prostate(5)|skin(2)|stomach(2)|urinary_tract(1)	78						TCTCTCTCCCCGCTCTGCTCA	0.498000													37	39					0	0	1	0	0
CASP8AP2	9994	broad.mit.edu	37	6	90578032	90578032	+	Missense_Mutation	SNP	G	G	C			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr6:90578032G>C	uc003pnr.3	+	7	5219	c.5023G>C	c.(5023-5025)Gtt>Ctt	p.V1675L	CASP8AP2_uc003pns.2_Intron|CASP8AP2_uc003pnt.3_Missense_Mutation_p.V1675L|CASP8AP2_uc011dzz.2_Missense_Mutation_p.V1675L	NM_001137667	NP_001131139	Q9UKL3	C8AP2_HUMAN	Homo sapiens caspase 8 associated protein 2 (CASP8AP2), transcript variant 2, mRNA.	1675					cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			NS(1)|endometrium(7)|kidney(6)|large_intestine(12)|lung(21)|ovary(2)|urinary_tract(2)	51		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		CTCACACTCTGTTGGGGAACA	0.378000													27	31					0	0	1	0	0
NUDT10	170685	broad.mit.edu	37	X	51076024	51076024	+	Silent	SNP	G	G	A	rs143435240	byFrequency	TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chrX:51076024G>A	uc004dph.3	+	1	427	c.207G>A	c.(205-207)gaG>gaA	p.E69E	NUDT10_uc004dpi.4_Silent_p.E69E	NM_153183	NP_694853	Q8NFP7	NUD10_HUMAN	Homo sapiens nudix (nucleoside diphosphate linked moiety X)-type motif 10 (NUDT10), mRNA.	69	Nudix hydrolase.					cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding	p.E69E(16)		cervix(1)|endometrium(8)|kidney(1)|large_intestine(1)|lung(1)|prostate(3)|upper_aerodigestive_tract(1)	16	Ovarian(276;0.236)					TGTACGAAGAGGCGGGAGTCA	0.657000													4	138					0	0	1	0	0
TAS1R1	80835	broad.mit.edu	37	1	6631245	6631245	+	Silent	SNP	C	C	T	rs150596151		TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr1:6631245C>T	uc001ant.3	+	1	564	c.468C>T	c.(466-468)gcC>gcT	p.A156A	TAS1R1_uc001anu.3_Silent_p.A156A|TAS1R1_uc021ofp.1_Silent_p.A78A	NM_138697	NP_619642	Q7RTX1	TS1R1_HUMAN	Homo sapiens taste receptor, type 1, member 1 (TAS1R1), transcript variant 2, mRNA.	156					sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			NS(2)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(13)|ovary(1)|skin(1)|urinary_tract(2)	29	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		CCACCACAGCCGCCCTGCTGA	0.607000													23	52					0	0	1	0	0
KIAA0100	9703	broad.mit.edu	37	17	26971163	26971163	+	Missense_Mutation	SNP	C	C	A			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr17:26971163C>A	uc002hbu.3	-	1	214	c.111G>T	c.(109-111)aaG>aaT	p.K37N	KIAA0100_uc002hbv.3_Missense_Mutation_p.K37N|KIAA0100_uc010crr.2_5'UTR	NM_014680	NP_055495	Q14667	K0100_HUMAN	Homo sapiens KIAA0100 (KIAA0100), mRNA.	37						extracellular region				breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(23)|ovary(2)|prostate(2)|skin(6)|stomach(2)|urinary_tract(3)	68	Lung NSC(42;0.00431)					CCGCCTGCAGCTTCCGCTGAC	0.488000											OREG0024280	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	39					1.96895e-08	2.03246e-08	1	1	0
KAT2A	2648	broad.mit.edu	37	17	40269761	40269761	+	Missense_Mutation	SNP	G	G	C			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr17:40269761G>C	uc002hyx.2	-	8	1423	c.1363C>G	c.(1363-1365)Ccc>Gcc	p.P455A		NM_021078	NP_066564	Q92830	KAT2A_HUMAN	Homo sapiens K(lysine) acetyltransferase 2A (KAT2A), mRNA.	455					chromatin remodeling|histone deubiquitination|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex|STAGA complex|transcription factor TFTC complex	H3 histone acetyltransferase activity|histone deacetylase binding|protein binding|transcription coactivator activity			central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	18						AGCTCCATGGGGATGTCACCC	0.627000													42	65					0	0	1	0	0
ZMIZ1	57178	broad.mit.edu	37	10	81037038	81037038	+	Silent	SNP	C	C	G			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr10:81037038C>G	uc001kaf.2	+	7	953	c.381C>G	c.(379-381)ccC>ccG	p.P127P	ZMIZ1_uc001kag.2_Silent_p.P3P|ZMIZ1_uc001kah.1_Silent_p.P3P	NM_020338	NP_065071	Q9ULJ6	ZMIZ1_HUMAN	Homo sapiens zinc finger, MIZ-type containing 1 (ZMIZ1), mRNA.	127					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(14)|ovary(2)|prostate(3)|skin(1)	30	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			CCATGCAGCCCCCTCTCAGCT	0.622000													4	38					0	0	1	0	0
C15orf53	400359	broad.mit.edu	37	15	38988831	38988831	+	Missense_Mutation	SNP	A	A	C			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr15:38988831A>C	uc001zkf.1	+	0	33	c.23A>C	c.(22-24)gAg>gCg	p.E8A		NM_207444	NP_997327	Q8NAA6	CO053_HUMAN	Homo sapiens chromosome 15 open reading frame 53 (C15orf53), mRNA.	8										endometrium(1)|large_intestine(1)|lung(2)|skin(1)|stomach(1)	6		all_cancers(109;1.75e-13)|all_epithelial(112;1.02e-11)|Lung NSC(122;1.9e-09)|all_lung(180;4.04e-08)|Melanoma(134;0.091)|Colorectal(260;0.198)		GBM - Glioblastoma multiforme(113;8.39e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0321)		GGGGCCCAAGAGGACCTGGGC	0.562000													36	84					0	0	1	0	0
PRICKLE4	29964	broad.mit.edu	37	6	41751890	41751890	+	Missense_Mutation	SNP	G	G	A			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr6:41751890G>A	uc011duf.1	+	3	402	c.154G>A	c.(154-156)Ggt>Agt	p.G52S	PRICKLE4_uc003ord.2_Non-coding_Transcript|TOMM6_uc003org.3_5'Flank|TOMM6_uc011dug.1_5'Flank	NM_013397	NP_037529	Q2TBC4	PRIC4_HUMAN	Homo sapiens prickle homolog 4 (Drosophila) (PRICKLE4), mRNA.	12	PET.					nucleus	zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)	13	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;8.38e-05)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			TCTGAGCTTGGGTTCCCTTTG	0.542000													48	82					0	0	1	0	0
BHLHE40	8553	broad.mit.edu	37	3	5024970	5024970	+	Missense_Mutation	SNP	A	A	C			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr3:5024970A>C	uc003bqf.3	+	4	1139	c.832A>C	c.(832-834)Att>Ctt	p.I278L	BHLHE40_uc011asw.2_Missense_Mutation_p.I138L	NM_003670	NP_003661	O14503	BHE40_HUMAN	Homo sapiens basic helix-loop-helix family, member e40 (BHLHE40), mRNA.	278						Golgi apparatus|nucleolus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)|skin(2)	12						GATCGGCGCAATTAAGCAAGA	0.537000													33	47					0	0	1	0	0
LGALS3	3958	broad.mit.edu	37	14	55604955	55604955	+	Missense_Mutation	SNP	C	C	T			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr14:55604955C>T	uc001xbr.3	+	2	299	c.211C>T	c.(211-213)Ccc>Tcc	p.P71S	LGALS3_uc021rtj.1_Missense_Mutation_p.P71S	NM_002306	NP_002297	P17931	LEG3_HUMAN	Homo sapiens lectin, galactoside-binding, soluble, 3 (LGALS3), transcript variant 1, mRNA.	71	8 X 9 AA tandem repeats of Y-P-G-X(3)-P- G-A.				RNA splicing|cell differentiation|innate immune response|mRNA processing	mitochondrial inner membrane|plasma membrane|spliceosomal complex	IgE binding|sugar binding			central_nervous_system(1)|endometrium(1)|prostate(1)	3						TGGAGCTTATCCCGGAGCACC	0.682000													19	33					0	0	1	0	0
CRNN	49860	broad.mit.edu	37	1	152384603	152384603	+	Missense_Mutation	SNP	A	A	G			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr1:152384603A>G	uc001ezx.2	-	1	181	c.107T>C	c.(106-108)cTc>cCc	p.L36P		NM_016190	NP_057274	Q9UBG3	CRNN_HUMAN	Homo sapiens cornulin (CRNN), mRNA.	36					cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(16)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTGCTCCAAGAGTCTTTTCAG	0.557000													56	76					0	0	1	0	0
FLNC	2318	broad.mit.edu	37	7	128494117	128494117	+	Missense_Mutation	SNP	G	G	C			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr7:128494117G>C	uc003vnz.4	+	39	6783	c.6574G>C	c.(6574-6576)Gag>Cag	p.E2192Q	FLNC_uc003voa.4_Missense_Mutation_p.E2159Q	NM_001458	NP_001449	Q14315	FLNC_HUMAN	Homo sapiens filamin C, gamma (FLNC), transcript variant 1, mRNA.	2192	Intradomain insert.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			biliary_tract(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(19)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(19)|lung(59)|ovary(2)|pancreas(2)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)	128						GGAGCGCACGGAGATCAGCAA	0.652000													82	141					0	0	1	0	0
RBP3	5949	broad.mit.edu	37	10	48388918	48388918	+	Missense_Mutation	SNP	G	G	C			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr10:48388918G>C	uc001jez.3	-	0	2074	c.1960C>G	c.(1960-1962)Cca>Gca	p.P654A		NM_002900	NP_002891	P10745	RET3_HUMAN	Homo sapiens retinol binding protein 3, interstitial (RBP3), mRNA.	654	4 X approximate tandem repeats.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(30)|ovary(1)|prostate(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59					Vitamin A(DB00162)	ACGACCTCTGGCCGAGCATAG	0.672000													35	45					0	0	1	0	0
OTOG	340990	broad.mit.edu	37	11	17633835	17633835	+	Missense_Mutation	SNP	C	C	T			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr11:17633835C>T	uc001mnh.1	+	12	3588	c.3304C>T	c.(3304-3306)Cgg>Tgg	p.R1102W				Q6ZRI0	OTOG_HUMAN	RecName: Full=Otogelin; Flags: Precursor;	2096	VWFD 3.				L-arabinose metabolic process	apical plasma membrane|extracellular space	alpha-N-arabinofuranosidase activity			breast(3)|central_nervous_system(1)|lung(1)|skin(1)	6						CCTCGCCGTGCGGGTGGGTGG	0.657000													3	29					0	0	1	0	0
CSTF2T	23283	broad.mit.edu	37	10	53458361	53458361	+	Missense_Mutation	SNP	C	C	T			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr10:53458361C>T	uc001jjp.3	-	0	995	c.949G>A	c.(949-951)Gga>Aga	p.G317R	PRKG1_uc001jjm.3_Intron|PRKG1_uc001jjn.2_Intron|PRKG1_uc001jjo.3_Intron	NM_015235	NP_056050	Q9H0L4	CSTFT_HUMAN	Homo sapiens cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant (CSTF2T), mRNA.	317	Gly-rich.				mRNA processing	nucleus	RNA binding|nucleotide binding	p.G317R(2)|p.R316H(2)		NS(1)|breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(6)|ovary(1)|prostate(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	30				COAD - Colon adenocarcinoma(2;0.00736)|Colorectal(2;0.00898)|all cancers(4;0.0188)|GBM - Glioblastoma multiforme(4;0.0778)|Epithelial(53;0.122)		GTCACGGGTCCGCGAGGTATA	0.567000													12	46					0	0	1	0	0
FOLR2	2350	broad.mit.edu	37	11	71931920	71931920	+	Missense_Mutation	SNP	C	C	A			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr11:71931920C>A	uc009yte.3	+	2	320	c.157C>A	c.(157-159)Ccc>Acc	p.P53T	FOLR2_uc009ytf.3_Missense_Mutation_p.P53T|FOLR2_uc009ytd.3_Missense_Mutation_p.P53T|FOLR2_uc001ose.4_Missense_Mutation_p.P53T	NM_001113535	NP_001107008	P14207	FOLR2_HUMAN	Homo sapiens folate receptor 2 (fetal) (FOLR2), transcript variant 3, mRNA.	53					folic acid transport	anchored to membrane|extracellular region|membrane fraction|plasma membrane	folic acid binding|receptor activity			breast(3)|large_intestine(3)|ovary(1)|skin(1)	8					Folic Acid(DB00158)	CCAGTGCAGTCCCTGGAAGAA	0.587000													29	53					5.8336e-16	6.43708e-16	1	1	0
KIR2DL2	3803	broad.mit.edu	37	GL000209.1	118691	118691	+	Silent	SNP	A	A	G			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chrGL000209.1:118691A>G	uc010yie.2	+	2	179	c.168A>G	c.(166-168)gaA>gaG	p.E56E	KIR2DL2_uc021vdc.1_Intron|KIR2DL2_uc021vdd.1_Intron|KIR2DL2_uc002qty.3_Silent_p.E53E|KIR2DL2_uc002qum.3_Silent_p.E56E	NM_014512	NP_055327	P43627	KI2L2_HUMAN	Homo sapiens killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 1 (KIR2DS1), mRNA.	56	Ig-like C2-type 1.				regulation of immune response	integral to membrane|plasma membrane	receptor activity										TCATGTTTGAACACTTCCTTC	0.512000													3	77					0	0	1	0	0
SPINK1	6690	broad.mit.edu	37	5	147207646	147207646	+	Missense_Mutation	SNP	G	G	A			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr5:147207646G>A	uc003los.2	-	2	253	c.133C>T	c.(133-135)Cct>Tct	p.P45S		NM_003122	NP_003113	P00995	ISK1_HUMAN	Homo sapiens serine peptidase inhibitor, Kazal type 1 (SPINK1), mRNA.	45	Kazal-like.					extracellular region	protein binding|serine-type endopeptidase inhibitor activity			endometrium(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCACAGACAGGGTCATATATC	0.328000									Hereditary Pancreatitis				17	53					0	0	1	0	0
GP9	2815	broad.mit.edu	37	3	128780901	128780901	+	Missense_Mutation	SNP	G	G	T			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr3:128780901G>T	uc003elm.2	+	2	506	c.319G>T	c.(319-321)Gcc>Tcc	p.A107S	GP9_uc021xdn.1_Missense_Mutation_p.A107S	NM_000174	NP_000165	P14770	GPIX_HUMAN	Homo sapiens glycoprotein IX (platelet) (GP9), mRNA.	107	LRRCT.				blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane	protein binding			NS(1)|central_nervous_system(1)|lung(4)	6					Quinine(DB00468)	CACGCCCGAGGCCCTGCTGCA	0.701000													11	122					2.80697e-09	2.94502e-09	1	1	0
GRAMD1A	57655	broad.mit.edu	37	19	35506763	35506763	+	Missense_Mutation	SNP	C	C	T			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr19:35506763C>T	uc010xsf.1	+	10	1120	c.1120C>T	c.(1120-1122)Cgc>Tgc	p.R374C	GRAMD1A_uc010xse.1_Missense_Mutation_p.R369C|GRAMD1A_uc002nxk.2_Missense_Mutation_p.R362C|GRAMD1A_uc002nxl.2_Missense_Mutation_p.R135C|GRAMD1A_uc002nxn.1_5'UTR	NM_020895	NP_065946	Q96CP6	GRM1A_HUMAN	Homo sapiens GRAM domain containing 1A (GRAMD1A), transcript variant 1, mRNA.	369						integral to membrane				NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)	19	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			CCTCTCCGGCCGCCTCCTCAT	0.642000													34	46					0	0	1	0	0
ARRDC3	57561	broad.mit.edu	37	5	90669948	90669948	+	Missense_Mutation	SNP	A	A	C			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr5:90669948A>C	uc003kjz.2	-	5	1256	c.1016T>G	c.(1015-1017)cTt>cGt	p.L339R		NM_020801	NP_065852	Q96B67	ARRD3_HUMAN	Homo sapiens arrestin domain containing 3 (ARRDC3), mRNA.	339					signal transduction	cytoplasm	protein binding			breast(2)|endometrium(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(1)|urinary_tract(1)	18		all_cancers(142;2.22e-05)|all_epithelial(76;1.58e-07)|all_lung(232;0.000521)|Lung NSC(167;0.000548)|Ovarian(174;0.0798)|Colorectal(57;0.207)		OV - Ovarian serous cystadenocarcinoma(54;4.56e-30)|Epithelial(54;7.55e-26)|all cancers(79;3.63e-22)		TCTTTCAGGAAGTGATAAACT	0.373000													23	67					0	0	1	0	0
BARX2	8538	broad.mit.edu	37	11	129321185	129321185	+	Missense_Mutation	SNP	T	T	A			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr11:129321185T>A	uc001qfc.4	+	3	778	c.728T>A	c.(727-729)cTc>cAc	p.L243H		NM_003658	NP_003649	Q9UMQ3	BARX2_HUMAN	Homo sapiens BARX homeobox 2 (BARX2), mRNA.	243								p.E242K(1)		breast(1)|central_nervous_system(1)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	20	all_hematologic(175;0.0749)	Lung NSC(97;0.000383)|all_lung(97;0.000824)|Breast(109;0.000962)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.00929)|Lung(977;0.0245)|LUSC - Lung squamous cell carcinoma(976;0.0253)		CAGGAGGAGCTCTGTGAAGCA	0.582000													44	64					0	0	1	0	0
PTPRF	5792	broad.mit.edu	37	1	44083552	44083552	+	Silent	SNP	C	C	T			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr1:44083552C>T	uc001cjr.3	+	24	4681	c.4341C>T	c.(4339-4341)gtC>gtT	p.V1447V	PTPRF_uc001cjs.3_Silent_p.V1438V|PTPRF_uc001cju.3_Silent_p.V836V|PTPRF_uc009vwt.3_Silent_p.V1007V|PTPRF_uc001cjv.3_Silent_p.V918V|PTPRF_uc001cjw.3_Silent_p.V673V	NM_002840	NP_002831	P10586	PTPRF_HUMAN	Homo sapiens protein tyrosine phosphatase, receptor type, F (PTPRF), transcript variant 1, mRNA.	1447	Tyrosine-protein phosphatase 1.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				CCACTGTGGTCATGATGACAC	0.637000													56	161					0	0	1	0	0
PPP4R4	57718	broad.mit.edu	37	14	94733352	94733352	+	Missense_Mutation	SNP	T	T	A			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr14:94733352T>A	uc001ycs.1	+	22	2589	c.2435T>A	c.(2434-2436)gTg>gAg	p.V812E		NM_058237	NP_478144	Q6NUP7	PP4R4_HUMAN	Homo sapiens protein phosphatase 4, regulatory subunit 4 (PPP4R4), transcript variant 1, mRNA.	812						cytoplasm|protein serine/threonine phosphatase complex	protein binding			NS(1)|breast(2)|central_nervous_system(1)|kidney(2)|large_intestine(15)|lung(10)|skin(7)|upper_aerodigestive_tract(2)	40						AAGACTTCTGTGCTTTCACTA	0.299000													14	30					0	0	1	0	0
KIAA0907	22889	broad.mit.edu	37	1	155903553	155903553	+	Silent	SNP	C	C	G	rs147323254		TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr1:155903553C>G	uc001fmi.1	-	1	150	c.126G>C	c.(124-126)ggG>ggC	p.G42G	KIAA0907_uc001fmj.1_Silent_p.G42G|KIAA0907_uc009wrl.1_Non-coding_Transcript|KIAA0907_uc001fml.1_Silent_p.G42G|KIAA0907_uc001fmm.3_Silent_p.G42G|KIAA0907_uc001fmo.3_Silent_p.G42G	NM_014949	NP_055764	Q7Z7F0	K0907_HUMAN	Homo sapiens KIAA0907 (KIAA0907), mRNA.	42										breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|urinary_tract(1)	21	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			CAGGACTTCCCCCACTGCTGG	0.617000													10	26					0	0	1	0	0
SLCO3A1	28232	broad.mit.edu	37	15	92647568	92647568	+	Missense_Mutation	SNP	C	C	A			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr15:92647568C>A	uc002bqx.2	+	3	1006	c.805C>A	c.(805-807)Ctg>Atg	p.L269M	SLCO3A1_uc002bqy.2_Missense_Mutation_p.L269M|SLCO3A1_uc010boc.1_Non-coding_Transcript|SLCO3A1_uc002bqz.1_Missense_Mutation_p.L211M	NM_013272	NP_037404	Q9UIG8	SO3A1_HUMAN	Homo sapiens solute carrier organic anion transporter family, member 3A1 (SLCO3A1), transcript variant 1, mRNA.	269					sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(6)|pancreas(1)|prostate(1)|skin(2)	25	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			GGGTGGCTTTCTGCTCTGCGG	0.577000													21	40					3.7963e-18	4.26252e-18	1	1	0
MUC2	4583	broad.mit.edu	37	11	1093099	1093099	+	Missense_Mutation	SNP	C	C	A			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr11:1093099C>A	uc001lsx.1	+	30	4945	c.4918C>A	c.(4918-4920)Cca>Aca	p.P1640T		NM_002457	NP_002448	Q02817	MUC2_HUMAN	Homo sapiens mucin 2, oligomeric mucus/gel-forming (MUC2), mRNA.	1667	Approximate repeats.					inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	tacggtgaccccaaccccaac	0.632000													3	66					0.115264	0.116172	1	1	0
GNB1	2782	broad.mit.edu	37	1	1720557	1720557	+	Missense_Mutation	SNP	A	A	C			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr1:1720557A>C	uc001aif.3	-	9	1214	c.851T>G	c.(850-852)cTc>cGc	p.L284R	GNB1_uc009vky.3_Missense_Mutation_p.L184R	NM_002074	NP_002065	P62873	GBB1_HUMAN	Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 1 (GNB1), mRNA.	284					Ras protein signal transduction|cellular response to glucagon stimulus|energy reserve metabolic process|muscarinic acetylcholine receptor signaling pathway|platelet activation|synaptic transmission	heterotrimeric G-protein complex	GTPase activity|GTPase binding|signal transducer activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(2)|lung(3)|skin(1)	12	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.62e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.14e-35)|OV - Ovarian serous cystadenocarcinoma(86;7.31e-23)|GBM - Glioblastoma multiforme(42;3.1e-07)|COAD - Colon adenocarcinoma(227;0.000323)|Colorectal(212;0.000374)|Kidney(185;0.00392)|BRCA - Breast invasive adenocarcinoma(365;0.00573)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.0482)|Lung(427;0.236)		AGCAAGGAGGAGGCGCCCGCT	0.572000											OREG0012998	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	50	59					0	0	1	0	0
COL14A1	7373	broad.mit.edu	37	8	121357692	121357692	+	Missense_Mutation	SNP	C	C	T			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr8:121357692C>T	uc003yox.3	+	44	5232	c.4967C>T	c.(4966-4968)cCt>cTt	p.P1656L	COL14A1_uc003yoz.3_Missense_Mutation_p.P621L	NM_021110	NP_066933	Q05707	COEA1_HUMAN	Homo sapiens collagen, type XIV, alpha 1 (COL14A1), mRNA.	1656	Triple-helical region 2 (COL1).				cell-cell adhesion|collagen fibril organization	collagen type XIV|extracellular space	collagen binding|extracellular matrix structural constituent|protein binding, bridging			NS(1)|autonomic_ganglia(1)|breast(11)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(9)|large_intestine(31)|lung(42)|ovary(5)|pancreas(1)|prostate(1)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)	119	Lung NSC(37;6.52e-07)|Ovarian(258;0.00769)|Hepatocellular(40;0.161)		OV - Ovarian serous cystadenocarcinoma(1;6.47e-38)|STAD - Stomach adenocarcinoma(47;0.00503)			CAAGGGCCTCCTGGGGAGCCT	0.622000													33	50					0	0	1	0	0
PCDHGC5	56097	broad.mit.edu	37	5	140788348	140788348	+	Missense_Mutation	SNP	G	G	T			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr5:140788348G>T	uc003lkj.2	+	0	579	c.579G>T	c.(577-579)gaG>gaT	p.E193D	PCDHGC5_uc003lji.2_Intron|PCDHGC5_uc003ljk.2_Intron|PCDHGC5_uc003ljm.2_Intron|PCDHGC5_uc003ljo.2_Intron|PCDHGC5_uc003ljq.2_Intron|PCDHGC5_uc003ljs.2_Intron|PCDHGC5_uc003lju.2_Intron|PCDHGC5_uc003ljw.2_Intron|PCDHGC5_uc003ljy.2_Intron|PCDHGC5_uc003lka.2_Intron|PCDHGC5_uc003lkc.2_Intron|PCDHGC5_uc003lkd.2_Intron|PCDHGC5_uc003lkf.2_Intron|PCDHGC5_uc003lkh.2_Intron|PCDHGC5_uc003lki.1_Missense_Mutation_p.E193D	NM_018926	NP_061749	Q9Y5F6	PCDGM_HUMAN	Homo sapiens protocadherin gamma subfamily B, 6 (PCDHGB6), transcript variant 1, mRNA.	193	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(2)|central_nervous_system(2)|endometrium(6)|kidney(4)|large_intestine(4)|lung(10)|ovary(4)|prostate(1)|urinary_tract(2)	35			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AATACCCAGAGTTATCTCTGG	0.403000													18	24					7.45023e-12	8.01369e-12	1	1	0
ZNF594	84622	broad.mit.edu	37	17	5086862	5086862	+	Missense_Mutation	SNP	C	C	G			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr17:5086862C>G	uc010cla.1	-	1	846	c.690G>C	c.(688-690)caG>caC	p.Q230H	ZNF594_uc021tol.1_Missense_Mutation_p.Q230H	NM_032530	NP_115919	Q96JF6	ZN594_HUMAN	Homo sapiens zinc finger protein 594 (ZNF594), mRNA.	230					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.Q230H(2)		NS(1)|breast(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(3)|lung(10)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						TGTGGATTCTCTGGTGCAGGA	0.438000													23	29					0	0	1	0	0
TRAF2	7186	broad.mit.edu	37	9	139794876	139794876	+	Silent	SNP	C	C	G			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr9:139794876C>G	uc004cjv.3	+	3	327	c.270C>G	c.(268-270)gcC>gcG	p.A90A	TRAF2_uc010nbu.3_Silent_p.A90A|TRAF2_uc010nbv.1_Silent_p.A90A|TRAF2_uc011mek.2_Silent_p.A79A|TRAF2_uc010nbw.3_Silent_p.A90A	NM_021138	NP_066961	Q12933	TRAF2_HUMAN	Homo sapiens TNF receptor-associated factor 2 (TRAF2), mRNA.	90					activation of NF-kappaB-inducing kinase activity|activation of caspase activity|activation of pro-apoptotic gene products|cellular protein complex assembly|induction of apoptosis by extracellular signals|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|positive regulation of interleukin-2 production|protein K63-linked ubiquitination|protein autoubiquitination|protein homotrimerization|tumor necrosis factor-mediated signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane	CD40 receptor binding|enzyme binding|protein binding|signal transducer activity|sphingolipid binding|ubiquitin-protein ligase activity|zinc ion binding			breast(3)|central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(4)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.229)	OV - Ovarian serous cystadenocarcinoma(145;4.48e-06)|Epithelial(140;9.55e-06)		CTCCCCAGGCCTTCCCAGATA	0.577000													13	31					0	0	1	0	0
TRPM6	140803	broad.mit.edu	37	9	77435298	77435298	+	Missense_Mutation	SNP	C	C	G			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr9:77435298C>G	uc004ajl.1	-	8	1294	c.1056G>C	c.(1054-1056)caG>caC	p.Q352H	TRPM6_uc004ajk.1_Missense_Mutation_p.Q347H|TRPM6_uc022bib.1_Missense_Mutation_p.Q347H|TRPM6_uc010mpb.1_Non-coding_Transcript|TRPM6_uc010mpc.1_Missense_Mutation_p.Q352H|TRPM6_uc010mpd.1_Missense_Mutation_p.Q352H|TRPM6_uc010mpe.1_Intron	NM_017662	NP_060132	Q9BX84	TRPM6_HUMAN	Homo sapiens transient receptor potential cation channel, subfamily M, member 6 (TRPM6), transcript variant a, mRNA.	352					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						TGAAAGTGTTCTGAATCATGC	0.438000													6	63					0	0	1	0	0
MYO5A	4644	broad.mit.edu	37	15	52680096	52680096	+	Missense_Mutation	SNP	C	C	A			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr15:52680096C>A	uc002aby.2	-	13	1926	c.1682G>T	c.(1681-1683)tGt>tTt	p.C561F	MYO5A_uc002abx.3_Missense_Mutation_p.C561F|MYO5A_uc010uge.1_Missense_Mutation_p.C430F	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	Homo sapiens myosin VA (heavy chain 12, myoxin) (MYO5A), transcript variant 1, mRNA.	561	Myosin head-like.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	ATP binding|actin binding|calmodulin binding|microfilament motor activity			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(12)|lung(19)|ovary(3)|skin(3)|stomach(1)	57				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		AAATCCTTCACACTGGTATTC	0.303000													4	6					0.014758	0.0151122	1	1	0
LOC645676	645676	broad.mit.edu	37	1	155532204	155532204	+	Missense_Mutation	SNP	A	A	T			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr1:155532204A>T	uc010pge.2	+	0	433	c.109A>T	c.(109-111)Aat>Tat	p.N37Y	ASH1L_uc001fkt.3_5'UTR|ASH1L_uc009wqq.3_5'UTR|ASH1L_uc009wqr.1_Intron|BC017347_uc001fkv.3_Intron					Homo sapiens uncharacterized LOC645676 (LOC645676), non-coding RNA.																		GCGAACCCAAAATggcggcgg	0.706000													5	11					0	0	1	0	0
UGT2B10	7365	broad.mit.edu	37	4	69884019	69884019	+	Missense_Mutation	SNP	A	A	G			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr4:69884019A>G	uc011cao.1	-	3	799	c.673T>C	c.(673-675)Ttc>Ctc	p.F225L	UGT2B10_uc011can.1_Missense_Mutation_p.F141L			P36537	UDB10_HUMAN	Homo sapiens UDP glucuronosyltransferase 2 family, polypeptide B10 (UGT2B10), transcript variant 1, mRNA.	269					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			endometrium(3)|kidney(4)|large_intestine(1)|lung(13)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	29						TTTGGTAAGAATGGATGAGGA	0.393000													32	90					0	0	1	0	0
HLA-E	3133	broad.mit.edu	37	6	30459405	30459405	+	Silent	SNP	T	T	C			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr6:30459405T>C	uc011dmh.2	+	3	1128	c.1101T>C	c.(1099-1101)gcT>gcC	p.A367A	HLA-E_uc011dmg.2_Non-coding_Transcript|HLA-E_uc003nqg.3_Silent_p.A326A			P13747	HLAE_HUMAN	Homo sapiens major histocompatibility complex, class I, E (HLA-E), mRNA.	326					antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	MHC class I protein complex|integral to membrane	MHC class I receptor activity			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(3)|large_intestine(2)|lung(1)|ovary(3)|skin(1)|urinary_tract(1)	18						TGGTTGCTGCTGTGATATGGA	0.557000													19	59					0	0	1	0	0
WBP11P1	441818	broad.mit.edu	37	18	30092430	30092430	+	RNA	SNP	C	C	T			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr18:30092430C>T	uc010dmc.3	+	0		c.805C>T								Homo sapiens WW domain binding protein 11 pseudogene 1 (WBP11P1), non-coding RNA.																		CTGGTCCACCCCCTCCTCAAG	0.537000													105	73					0	0	1	0	0
MGC39584	441058	broad.mit.edu	37	GL000193.1	88286	88286	+	RNA	SNP	G	G	A			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chrGL000193.1:88286G>A	uc003izx.3	-	0		c.90C>T			MGC39584_uc003izy.3_5'Flank					Homo sapiens uncharacterized LOC441058 (MGC39584), non-coding RNA.																		atcatggtcggccctttgcga	0.632000													4	13					0	0	1	0	0
RSPH6A	81492	broad.mit.edu	37	19	46305454	46305454	+	Missense_Mutation	SNP	C	C	G			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr19:46305454C>G	uc002pdm.3	-	3	1893	c.1722G>C	c.(1720-1722)gaG>gaC	p.E574D	RSPH6A_uc002pdl.3_Missense_Mutation_p.E310D	NM_030785	NP_110412	Q9H0K4	RSH6A_HUMAN	Homo sapiens radial spoke head 6 homolog A (Chlamydomonas) (RSPH6A), mRNA.	574	Glu-rich.					intracellular				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	32						catctgccttctcttcctcct	0.622000													37	68					0	0	1	0	0
HDGF	3068	broad.mit.edu	37	1	156713547	156713547	+	Missense_Mutation	SNP	C	C	T			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr1:156713547C>T	uc001fpy.4	-	4	935	c.613G>A	c.(613-615)Ggc>Agc	p.G205S	MRPL24_uc001fpw.1_5'Flank|MRPL24_uc001fpx.1_5'Flank|HDGF_uc009wsd.3_Missense_Mutation_p.G173S|HDGF_uc001fpz.4_Missense_Mutation_p.G198S|HDGF_uc009wse.3_Missense_Mutation_p.G221S|HDGF_uc010phr.2_Missense_Mutation_p.G228S|HDGF_uc009wsf.3_Missense_Mutation_p.G173S	NM_004494	NP_004485	P51858	HDGF_HUMAN	Homo sapiens hepatoma-derived growth factor (HDGF), transcript variant 1, mRNA.	205	Glu-rich.				cell proliferation|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus	DNA binding|growth factor activity|heparin binding|nucleotide binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(6)	9	all_hematologic(923;0.088)|Hepatocellular(266;0.158)	Breast(1374;0.198)		Colorectal(1306;0.018)		CGGCCAGAGCCGGGCTCAGAG	0.587000													26	24					0	0	1	0	0
OTUD7A	161725	broad.mit.edu	37	15	31818596	31818596	+	Silent	SNP	G	G	A			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr15:31818596G>A	uc001zfq.3	-	5	921	c.828C>T	c.(826-828)agC>agT	p.S276S	OTUD7A_uc001zfr.3_Silent_p.S283S	NM_130901	NP_570971	Q8TE49	OTU7A_HUMAN	Homo sapiens OTU domain containing 7A (OTUD7A), mRNA.	276	Catalytic (By similarity).|OTU.|TRAF-binding (By similarity).					cytoplasm|nucleus	DNA binding|cysteine-type peptidase activity|zinc ion binding			endometrium(7)|large_intestine(4)|lung(11)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(4)	30		all_lung(180;1.6e-09)		all cancers(64;2.44e-19)|Epithelial(43;6.82e-14)|GBM - Glioblastoma multiforme(186;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00189)|Lung(196;0.208)		TGCGCGGCTCGCTGGAGGCCA	0.677000													5	13					0	0	1	0	0
EPRS	2058	broad.mit.edu	37	1	220154162	220154162	+	Missense_Mutation	SNP	G	G	C			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr1:220154162G>C	uc001hly.1	-	24	3761	c.3491C>G	c.(3490-3492)aCt>aGt	p.T1164S	RNU5F-1_uc021pjd.1_Intron	NM_004446	NP_004437	P07814	SYEP_HUMAN	Homo sapiens glutamyl-prolyl-tRNA synthetase (EPRS), mRNA.	1164	Prolyl-tRNA synthetase.				glutamyl-tRNA aminoacylation|prolyl-tRNA aminoacylation|protein complex assembly	cytosol|soluble fraction	ATP binding|RNA binding|glutamate-tRNA ligase activity|proline-tRNA ligase activity|protein binding			breast(2)|endometrium(11)|kidney(2)|large_intestine(13)|lung(24)|ovary(1)|prostate(3)|skin(2)|stomach(2)|urinary_tract(3)	63				GBM - Glioblastoma multiforme(131;0.0735)	L-Glutamic Acid(DB00142)|L-Proline(DB00172)	AAATTCACGAGTACGTAGGAA	0.388000													52	90					0	0	1	0	0
XPC	7508	broad.mit.edu	37	3	14188804	14188804	+	Missense_Mutation	SNP	G	G	C			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr3:14188804G>C	uc011ave.2	-	14	2694	c.2590C>G	c.(2590-2592)Cgc>Ggc	p.R864G	XPC_uc011avf.2_Missense_Mutation_p.R671G|XPC_uc011avg.2_Missense_Mutation_p.R827G	NM_004628	NP_004619	Q01831	XPC_HUMAN	Homo sapiens xeroderma pigmentosum, complementation group C (XPC), transcript variant 1, mRNA.	864	Interaction with CETN2.|Interaction with ERCC2 and GTF2H1.				nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal	XPC complex|cytoplasm|nucleoplasm	bubble DNA binding|damaged DNA binding|loop DNA binding|protein binding|single-stranded DNA binding			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						GGCCCGTAGCGACGCTTCAGC	0.547000			"""Mis, N, F, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				5	71					0	0	1	0	0
ZFYVE26	23503	broad.mit.edu	37	14	68268851	68268851	+	Silent	SNP	G	G	T			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr14:68268851G>T	uc001xka.2	-	9	1723	c.1584C>A	c.(1582-1584)ctC>ctA	p.L528L	ZFYVE26_uc010tsz.1_Intron|ZFYVE26_uc001xkc.4_Silent_p.L528L|ZFYVE26_uc010tta.2_Silent_p.L528L	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	Homo sapiens zinc finger, FYVE domain containing 26 (ZFYVE26), mRNA.	528					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			NS(1)|breast(3)|cervix(1)|endometrium(6)|kidney(8)|large_intestine(8)|lung(39)|ovary(12)|pancreas(1)|prostate(7)|skin(3)|stomach(1)|upper_aerodigestive_tract(4)	94				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		GGTCCTCAGAGAGGCTGTCTT	0.537000													56	92					1.20466e-24	1.40179e-24	1	1	0
ITGAD	3681	broad.mit.edu	37	16	31414951	31414951	+	Missense_Mutation	SNP	G	G	A			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr16:31414951G>A	uc010cap.1	+	6	738	c.689G>A	c.(688-690)gGc>gAc	p.G230D	ITGAD_uc010vfl.1_Missense_Mutation_p.G230D|ITGAD_uc002ebv.1_Missense_Mutation_p.G230D|ITGAD_uc002ebw.1_Missense_Mutation_p.G41D	NM_005353	NP_005344	Q13349	ITAD_HUMAN	Homo sapiens integrin, alpha D (ITGAD), mRNA.	230	VWFA.				cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity	p.T229K(1)		breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|liver(2)|lung(43)|ovary(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	71						ACGGCCACGGGCATCCTGACA	0.607000													44	77					0	0	1	0	0
IPO9	55705	broad.mit.edu	37	1	201842054	201842054	+	Missense_Mutation	SNP	A	A	C			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr1:201842054A>C	uc001gwz.3	+	19	2725	c.2675A>C	c.(2674-2676)gAt>gCt	p.D892A		NM_018085	NP_060555	Q96P70	IPO9_HUMAN	Homo sapiens importin 9 (IPO9), mRNA.	892					protein import into nucleus	cytoplasm|nucleus	histone binding|protein transporter activity			cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	38						TACAGCATGGATGAGGGCATC	0.532000													64	77					0	0	1	0	0
SHMT2	6472	broad.mit.edu	37	12	57624649	57624649	+	Missense_Mutation	SNP	C	C	G			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr12:57624649C>G	uc001snf.2	+	1	303	c.97C>G	c.(97-99)Cag>Gag	p.Q33E	SHMT2_uc001snh.2_Silent_p.P61P|SHMT2_uc009zpk.2_Missense_Mutation_p.Q33E|SHMT2_uc001sng.2_5'UTR|SHMT2_uc001sni.2_Missense_Mutation_p.Q12E|SHMT2_uc010srg.2_Silent_p.P68P|SHMT2_uc010srh.2_Missense_Mutation_p.Q12E|SHMT2_uc001snj.2_5'UTR|SHMT2_uc010sri.2_Missense_Mutation_p.Q12E|SHMT2_uc001snk.2_5'UTR|SHMT2_uc010srj.2_5'Flank	NM_005412	NP_001159831	P34897	GLYM_HUMAN	Homo sapiens serine hydroxymethyltransferase 2 (mitochondrial) (SHMT2), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	33						microtubule cytoskeleton|mitochondrial nucleoid	glycine hydroxymethyltransferase activity|methyltransferase activity			breast(1)|central_nervous_system(1)|large_intestine(4)|liver(2)|lung(3)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	15					Glycine(DB00145)|Pyridoxal Phosphate(DB00114)|Tetrahydrofolic acid(DB00116)	CAACGCAGCCCAGACTCAGAC	0.582000													132	191					0	0	1	0	0
NAMPT	10135	broad.mit.edu	37	7	105903928	105903928	+	Missense_Mutation	SNP	T	T	G			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr7:105903928T>G	uc003vdq.3	-	6	1187	c.879A>C	c.(877-879)gaA>gaC	p.E293D	NAMPT_uc003vdr.1_Missense_Mutation_p.E293D|NAMPT_uc011klu.1_Missense_Mutation_p.E206D	NM_005746	NP_005737	P43490	NAMPT_HUMAN	Homo sapiens nicotinamide phosphoribosyltransferase (NAMPT), mRNA.	293					NAD biosynthetic process|cell-cell signaling|nicotinamide metabolic process|positive regulation of cell proliferation|positive regulation of nitric-oxide synthase biosynthetic process|signal transduction|water-soluble vitamin metabolic process	cytosol	cytokine activity|nicotinamide phosphoribosyltransferase activity|nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	14						GTCTTAGATCTTCACCCCATA	0.368000													11	123					0	0	1	0	0
INTS3	65123	broad.mit.edu	37	1	153735733	153735733	+	Missense_Mutation	SNP	A	A	T			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr1:153735733A>T	uc009wom.3	+	16	1882	c.1661A>T	c.(1660-1662)cAc>cTc	p.H554L	INTS3_uc001fct.3_Missense_Mutation_p.H554L|INTS3_uc001fcu.3_Missense_Mutation_p.H246L|INTS3_uc001fcv.3_Missense_Mutation_p.H348L|INTS3_uc010peb.2_Missense_Mutation_p.H348L|INTS3_uc001fcw.3_Missense_Mutation_p.H67L|INTS3_uc010pec.2_Missense_Mutation_p.H67L	NM_023015	NP_075391	Q68E01	INT3_HUMAN	Homo sapiens integrator complex subunit 3 (INTS3), mRNA.	555					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	SOSS complex|integrator complex	protein binding			breast(1)|cervix(4)|endometrium(10)|kidney(1)|large_intestine(6)|lung(9)|ovary(2)|pancreas(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	38	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			TTTCGCTTCCACCCTATCAAG	0.493000													38	89					0	0	1	0	0
DBNDD1	79007	broad.mit.edu	37	16	90075270	90075270	+	Missense_Mutation	SNP	T	T	A			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr16:90075270T>A	uc002fqe.1	-	2	375	c.301A>T	c.(301-303)Acc>Tcc	p.T101S	DBNDD1_uc002fqf.1_Missense_Mutation_p.T81S|DBNDD1_uc002fqg.1_Non-coding_Transcript	NM_024043	NP_076948	Q9H9R9	DBND1_HUMAN	Homo sapiens dysbindin (dystrobrevin binding protein 1) domain containing 1 (DBNDD1), transcript variant 2, mRNA.	81						cytoplasm				kidney(1)|large_intestine(1)|lung(1)	3		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0275)		GACATGTCGGTGAGCTCAGTG	0.642000													20	69					0	0	1	0	0
EIF2C2	27161	broad.mit.edu	37	8	141557696	141557696	+	Missense_Mutation	SNP	A	A	G			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr8:141557696A>G	uc003yvn.3	-	12	1660	c.1619T>C	c.(1618-1620)cTg>cCg	p.L540P	EIF2C2_uc010meo.3_Missense_Mutation_p.L540P|EIF2C2_uc010men.3_Missense_Mutation_p.L463P	NM_012154	NP_036286	Q9UKV8	AGO2_HUMAN	Homo sapiens eukaryotic translation initiation factor 2C, 2 (EIF2C2), transcript variant 1, mRNA.	540	Piwi.				mRNA cleavage involved in gene silencing by miRNA|negative regulation of translation involved in gene silencing by miRNA|negative regulation of translational initiation|pre-miRNA processing|regulation of transcription, DNA-dependent|transcription, DNA-dependent	RNA-induced silencing complex|cytoplasmic mRNA processing body|cytosol|mRNA cap binding complex|micro-ribonucleoprotein complex|nucleus|polysome	RNA 7-methylguanosine cap binding|endoribonuclease activity, cleaving siRNA-paired mRNA|metal ion binding|protein binding|siRNA binding|translation initiation factor activity			NS(1)|endometrium(5)|kidney(7)|large_intestine(4)|lung(13)|prostate(1)|skin(1)|urinary_tract(1)	33	all_cancers(97;2.54e-14)|all_epithelial(106;5.99e-13)|Lung NSC(106;1.45e-05)|all_lung(105;2.07e-05)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.159)	BRCA - Breast invasive adenocarcinoma(115;0.158)			GGCCATCCCCAGCACCGTGTC	0.637000													33	61					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19500887	19500887	+	Missense_Mutation	SNP	G	G	T			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr1:19500887G>T	uc001bbi.3	-	21	2912	c.2908C>A	c.(2908-2910)Ctg>Atg	p.L970M	UBR4_uc001bbm.1_Missense_Mutation_p.L181M	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	Homo sapiens ubiquitin protein ligase E3 component n-recognin 4 (UBR4), mRNA.	970					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		AGGGCTGTCAGTGCAGCATAA	0.438000													8	20					1.33987e-11	1.4292e-11	1	1	0
PHKB	5257	broad.mit.edu	37	16	47622955	47622955	+	Missense_Mutation	SNP	G	G	A			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr16:47622955G>A	uc002eev.4	+	9	1062	c.1010G>A	c.(1009-1011)gGg>gAg	p.G337E	PHKB_uc002eeu.4_Missense_Mutation_p.G330E	NM_000293	NP_000284	Q93100	KPBB_HUMAN	Homo sapiens phosphorylase kinase, beta (PHKB), transcript variant 1, mRNA.	337					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(10)|liver(1)|lung(18)|ovary(1)|skin(1)	41		all_cancers(37;0.00447)|all_lung(18;0.00616)|Lung NSC(13;0.0418)|Breast(268;0.203)				TTGAGAGATGGGTATAGAACA	0.353000													19	60					0	0	1	0	0
SBK2	646643	broad.mit.edu	37	19	56047489	56047489	+	Missense_Mutation	SNP	A	A	C			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr19:56047489A>C	uc010ygc.2	-	1	188	c.173T>G	c.(172-174)gTg>gGg	p.V58G		NM_001101401	NP_001094871	P0C263	SBK2_HUMAN	Homo sapiens SH3-binding domain kinase family, member 2 (SBK2), mRNA.	58							ATP binding|protein serine/threonine kinase activity			endometrium(1)|lung(5)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	9						GAGCTCGTCCACCTCGGCTCG	0.657000													17	65					0	0	1	0	0
GABRB2	2561	broad.mit.edu	37	5	160886718	160886718	+	Missense_Mutation	SNP	T	T	A			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr5:160886718T>A	uc003lys.1	-	4	588	c.370A>T	c.(370-372)Aac>Tac	p.N124Y	GABRB2_uc011deh.1_Intron|GABRB2_uc003lyr.1_Missense_Mutation_p.N124Y|GABRB2_uc003lyt.1_Missense_Mutation_p.N124Y|GABRB2_uc021yhg.1_Missense_Mutation_p.N61Y|GABRB2_uc011dei.1_Missense_Mutation_p.N124Y	NM_021911	NP_068711	P47870	GBRB2_HUMAN	Homo sapiens gamma-aminobutyric acid (GABA) A receptor, beta 2 (GABRB2), transcript variant 1, mRNA.	124					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	GABA-A receptor activity|chloride channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(9)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	26	Renal(175;0.00259)	Medulloblastoma(196;0.021)|all_neural(177;0.0463)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	TTCTTATCGTTCAGGAAATAG	0.478000													90	106					0	0	1	0	0
OR2M5	127059	broad.mit.edu	37	1	248309355	248309355	+	Silent	SNP	G	G	A			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr1:248309355G>A	uc010pze.2	+	0	906	c.906G>A	c.(904-906)agG>agA	p.R302R		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	Homo sapiens olfactory receptor, family 2, subfamily M, member 5 (OR2M5), mRNA.	302					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(5)|kidney(2)|large_intestine(7)|liver(1)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	49	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			GAGCACTCAGGAAAGTGTTAG	0.453000													7	128					0	0	1	0	0
TEX10	54881	broad.mit.edu	37	9	103109141	103109141	+	Missense_Mutation	SNP	C	C	G			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr9:103109141C>G	uc004bas.3	-	2	943	c.728G>C	c.(727-729)aGt>aCt	p.S243T	TEX10_uc011lvf.2_Missense_Mutation_p.S82T|TEX10_uc011lvg.2_Missense_Mutation_p.S246T|TEX10_uc011lvh.1_Missense_Mutation_p.S178T	NM_017746	NP_060216	Q9NXF1	TEX10_HUMAN	Homo sapiens testis expressed 10 (TEX10), transcript variant 1, mRNA.	243						MLL1 complex|integral to membrane|nuclear membrane|nucleolus	binding			NS(1)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(7)|lung(14)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(2)	38		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		TCTCAACCTACTGGATCCATC	0.448000													22	45					0	0	1	0	0
MYO5A	4644	broad.mit.edu	37	15	52680095	52680095	+	Missense_Mutation	SNP	A	A	C			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr15:52680095A>C	uc002aby.2	-	13	1927	c.1683T>G	c.(1681-1683)tgT>tgG	p.C561W	MYO5A_uc002abx.3_Missense_Mutation_p.C561W|MYO5A_uc010uge.1_Missense_Mutation_p.C430W	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	Homo sapiens myosin VA (heavy chain 12, myoxin) (MYO5A), transcript variant 1, mRNA.	561	Myosin head-like.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	ATP binding|actin binding|calmodulin binding|microfilament motor activity			breast(4)|central_nervous_system(1)|cervix(2)|endometrium(5)|kidney(7)|large_intestine(12)|lung(19)|ovary(3)|skin(3)|stomach(1)	57				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		GAAATCCTTCACACTGGTATT	0.303000													4	8					0	0	1	0	0
KAT7	11143	broad.mit.edu	37	17	47869395	47869395	+	Splice_Site	SNP	G	G	A			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr17:47869395G>A	uc002ipm.3	+	2	379	c.163_splice	c.e2+1	p.D55_splice	KAT7_uc002ipl.2_Splice_Site_p.D55_splice|KAT7_uc010wma.2_Splice_Site_p.G55_splice|KAT7_uc010wmb.2_Splice_Site_p.D55_splice|KAT7_uc010wmc.2_Splice_Site_p.G55_splice|KAT7_uc010wmd.2_Splice_Site|KAT7_uc010wme.2_Splice_Site	NM_007067	NP_008998	O95251	MYST2_HUMAN	Homo sapiens K(lysine) acetyltransferase 7 (KAT7), transcript variant 1, mRNA.	55	Ser-rich.				DNA replication|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	histone acetyltransferase activity|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding										GAGTTCTCAAGGTAAAAAAAC	0.493000													10	21					0	0	1	0	0
RNLS	55328	broad.mit.edu	37	10	90342858	90342858	+	Silent	SNP	A	A	C			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr10:90342858A>C	uc001kfe.3	-	0	225	c.90T>G	c.(88-90)ctT>ctG	p.L30L	RNLS_uc010qms.1_Silent_p.L30L|RNLS_uc001kfd.2_Silent_p.L30L	NM_001031709	NP_001026879	Q5VYX0	RNLS_HUMAN	Homo sapiens renalase, FAD-dependent amine oxidase (RNLS), transcript variant 1, mRNA.	30						extracellular region	oxidoreductase activity			breast(1)|kidney(1)|lung(3)|ovary(1)|prostate(1)	7						CCCACACAGCAAGGTACAAGG	0.632000											OREG0020353	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	41	84					0	0	1	0	0
RPE	6120	broad.mit.edu	37	2	210881324	210881324	+	Missense_Mutation	SNP	G	G	A			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr2:210881324G>A	uc002vdn.3	+	3	470	c.436G>A	c.(436-438)Ggg>Agg	p.G146R	RPE_uc002vdo.3_Missense_Mutation_p.G96R|RPE_uc002vdp.3_Missense_Mutation_p.G93R|RPE_uc010zjf.2_Missense_Mutation_p.G146R|RPE_uc010fup.3_Missense_Mutation_p.G78R|RPE_uc002vdq.3_Missense_Mutation_p.G96R|RPE_uc002vdr.3_Intron	NM_199229	NP_954699	Q96AT9	RPE_HUMAN	Homo sapiens ribulose-5-phosphate-3-epimerase (RPE), transcript variant 1, mRNA.	146	Substrate binding.				pentose-phosphate shunt	cytosol	metal ion binding|protein homodimerization activity|ribulose-phosphate 3-epimerase activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|skin(2)	9				Epithelial(149;0.00241)|Lung(261;0.041)|all cancers(144;0.0429)|LUSC - Lung squamous cell carcinoma(261;0.0431)		AGTGGAACCGGGGTTTGGAGG	0.438000													88	27					0	0	1	0	0
VIM	7431	broad.mit.edu	37	10	17278345	17278345	+	Silent	SNP	T	T	G			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr10:17278345T>G	uc001iou.2	+	8	1739	c.1326T>G	c.(1324-1326)ctT>ctG	p.L442L		NM_003380	NP_003371	P08670	VIME_HUMAN	Homo sapiens vimentin (VIM), mRNA.	442	Tail.			L -> F (in Ref. 1; AAA61279).	cellular component disassembly involved in apoptosis|cellular component movement|interspecies interaction between organisms|muscle filament sliding	cytosol|intermediate filament	protein C-terminus binding|structural constituent of cytoskeleton			NS(1)|autonomic_ganglia(1)|breast(1)|endometrium(3)|kidney(1)|large_intestine(4)|liver(2)|lung(18)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						AAAGGACACTTCTGATTAAGA	0.348000													25	31					0	0	1	0	0
PRMT6	55170	broad.mit.edu	37	1	107599742	107599742	+	Silent	SNP	C	C	T			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr1:107599742C>T	uc010ous.2	+	0	476	c.405C>T	c.(403-405)gtC>gtT	p.V135V		NM_018137	NP_060607	Q96LA8	ANM6_HUMAN	Homo sapiens protein arginine methyltransferase 6 (PRMT6), mRNA.	135					base-excision repair|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone binding|histone methyltransferase activity (H2A-R3 specific)|histone methyltransferase activity (H3-R2 specific)|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N asymmetric methyltransferase activity|protein-arginine omega-N monomethyltransferase activity			biliary_tract(1)|breast(2)|kidney(1)|large_intestine(4)|lung(5)|urinary_tract(1)	14		all_epithelial(167;0.000429)|all_lung(203;0.00122)|Lung NSC(277;0.00185)		Lung(183;0.0305)|Epithelial(280;0.0765)|Colorectal(144;0.0998)|all cancers(265;0.14)|LUSC - Lung squamous cell carcinoma(189;0.173)|BRCA - Breast invasive adenocarcinoma(282;0.242)		GGGTGCACGTCCTGCCGGGAC	0.672000													8	15					0	0	1	0	0
WDR90	197335	broad.mit.edu	37	16	707787	707787	+	Silent	SNP	C	C	T			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr16:707787C>T	uc002cii.1	+	20	2553	c.2499C>T	c.(2497-2499)ccC>ccT	p.P833P	WDR90_uc002cij.1_Intron|WDR90_uc002cik.1_Silent_p.P360P|WDR90_uc002cil.1_Non-coding_Transcript|WDR90_uc002cim.1_Silent_p.P7P	NM_145294	NP_660337	Q96KV7	WDR90_HUMAN	Homo sapiens WD repeat domain 90 (WDR90), mRNA.	833										endometrium(4)|kidney(3)|large_intestine(2)|lung(22)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	37		Hepatocellular(780;0.0218)				CGGATGCCCCCGCGAGCCCCA	0.726000													59	145					0	0	1	0	0
FNDC9	408263	broad.mit.edu	37	5	156770121	156770121	+	Nonsense_Mutation	SNP	C	C	A			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr5:156770121C>A	uc003lwu.2	-	1	612	c.424G>T	c.(424-426)Gag>Tag	p.E142*	CYFIP2_uc021ygm.1_Intron|CYFIP2_uc011ddn.2_Intron|CYFIP2_uc011ddo.2_Intron|CYFIP2_uc021ygn.1_Intron|CYFIP2_uc021ygo.1_Intron|CYFIP2_uc003lwt.3_Intron|CYFIP2_uc011ddp.2_Intron|FNDC9_uc021ygp.1_Nonsense_Mutation_p.E142*	NM_001001343	NP_001001343	Q8TBE3	FNDC9_HUMAN	Homo sapiens fibronectin type III domain containing 9 (FNDC9), mRNA.	142						integral to membrane				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)|skin(1)|urinary_tract(1)	9						CATCGCGGCTCATGGCAACGG	0.607000											OREG0016977	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	34	81					1.07121e-22	1.22424e-22	1	1	0
ZBTB46	140685	broad.mit.edu	37	20	62378613	62378613	+	Missense_Mutation	SNP	G	G	T			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr20:62378613G>T	uc002ygv.2	-	4	1641	c.1440C>A	c.(1438-1440)agC>agA	p.S480R	ZBTB46_uc002ygu.3_Non-coding_Transcript	NM_025224	NP_079500	Q86UZ6	ZBT46_HUMAN	Homo sapiens zinc finger and BTB domain containing 46 (ZBTB46), mRNA.	480					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(9)|lung(9)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	all_cancers(38;2.09e-12)|all_epithelial(29;3.8e-14)|Lung NSC(23;7.61e-10)|all_lung(23;2.64e-09)					TGAAGACGCGGCTGCACACCT	0.701000													30	48					1.30916e-28	1.53737e-28	1	1	0
GPR65	8477	broad.mit.edu	37	14	88478074	88478074	+	Missense_Mutation	SNP	G	G	A			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr14:88478074G>A	uc021rxh.1	+	0	883	c.883G>A	c.(883-885)Gaa>Aaa	p.E295K	GPR65_uc001xvv.3_Missense_Mutation_p.E295K	NM_003608	NP_003599	Q8IYL9	PSYR_HUMAN	Homo sapiens G protein-coupled receptor 65 (GPR65), mRNA.	295					actin cytoskeleton reorganization|activation of Rho GTPase activity|apoptosis|immune response|multicellular organismal development|positive regulation of cAMP biosynthetic process|positive regulation of stress fiber assembly|response to acidity	integral to plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|prostate(1)	16						TTTTGTAACCGAAACAGGAAG	0.353000													10	142					0	0	1	0	0
NOC3L	64318	broad.mit.edu	37	10	96121495	96121495	+	Silent	SNP	T	T	C			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr10:96121495T>C	uc001kjq.1	-	1	232	c.144A>G	c.(142-144)aaA>aaG	p.K48K	NOC3L_uc009xuk.1_5'UTR	NM_022451	NP_071896	Q8WTT2	NOC3L_HUMAN	Homo sapiens nucleolar complex associated 3 homolog (S. cerevisiae) (NOC3L), mRNA.	48						nuclear speck|nucleolus	binding			endometrium(3)|large_intestine(17)|lung(5)|ovary(1)|skin(2)|stomach(1)	29		Colorectal(252;0.0897)				CTTGCCTTAGTTTCCTCTGTT	0.368000													21	37					0	0	1	0	0
MXD1	4084	broad.mit.edu	37	2	70165384	70165384	+	Missense_Mutation	SNP	C	C	G			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr2:70165384C>G	uc002sfy.3	+	5	924	c.634C>G	c.(634-636)Cag>Gag	p.Q212E	MXD1_uc010yqp.2_Missense_Mutation_p.Q211E|MXD1_uc010yqs.2_Missense_Mutation_p.Q202E|MXD1_uc010yqq.2_Missense_Mutation_p.Q149E|MXD1_uc010yqr.2_Non-coding_Transcript|MXD1_uc021vix.1_Non-coding_Transcript	NM_002357	NP_002348	Q05195	MAD1_HUMAN	Homo sapiens MAX dimerization protein 1 (MXD1), transcript variant 1, mRNA.	212					cell proliferation|multicellular organismal development	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			breast(1)|endometrium(1)|large_intestine(3)|lung(1)|upper_aerodigestive_tract(1)	7						AATAAAGCTGCAGGACAGTCA	0.547000													20	248					0	0	1	0	0
USP48	84196	broad.mit.edu	37	1	22073615	22073615	+	Silent	SNP	A	A	G			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr1:22073615A>G	uc010odq.2	-	7	1174	c.936T>C	c.(934-936)aaT>aaC	p.N312N	USP48_uc001bfb.3_Silent_p.N312N|USP48_uc009vqc.3_Silent_p.N312N|USP48_uc001bfc.3_Silent_p.N312N|USP48_uc001bfe.1_Silent_p.N312N|USP48_uc001bff.3_Silent_p.N312N	NM_032236	NP_115612	Q86UV5	UBP48_HUMAN	Homo sapiens ubiquitin specific peptidase 48 (USP48), transcript variant 1, mRNA.	312					ubiquitin-dependent protein catabolic process	mitochondrion|nucleus	cysteine-type peptidase activity|ubiquitin thiolesterase activity			NS(1)|endometrium(6)|kidney(2)|large_intestine(11)|lung(14)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	42		Colorectal(325;3.46e-05)|all_lung(284;4.29e-05)|Lung NSC(340;4.66e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|OV - Ovarian serous cystadenocarcinoma(117;4.74e-26)|COAD - Colon adenocarcinoma(152;1.3e-05)|GBM - Glioblastoma multiforme(114;1.86e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000614)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(1967;0.00711)|Lung(427;0.0327)|READ - Rectum adenocarcinoma(331;0.0657)|LUSC - Lung squamous cell carcinoma(448;0.0753)		CAATGTAGGTATTCAGCTTTT	0.313000													4	8					0	0	1	0	0
MAPKAPK3	7867	broad.mit.edu	37	3	50685441	50685441	+	Silent	SNP	C	C	G			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr3:50685441C>G	uc003day.2	+	12	1755	c.1113C>G	c.(1111-1113)ggC>ggG	p.G371G	MAPKAPK3_uc003daz.2_Silent_p.G371G|MAPKAPK3_uc003dba.2_Silent_p.G371G|MAPKAPK3_uc010hlr.2_Silent_p.G371G	NM_001243926	NP_001230855	Q16644	MAPK3_HUMAN	Homo sapiens mitogen-activated protein kinase-activated protein kinase 3 (MAPKAPK3), transcript variant 1, mRNA.	371					MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|Ras protein signal transduction|Toll signaling pathway|activation of MAPK activity|innate immune response|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein serine/threonine kinase activity			central_nervous_system(1)|ovary(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.0188)|Kidney(197;0.0223)		AGCAGGCAGGCAGCTCCTCTG	0.562000													86	125					0	0	1	0	0
DENND4B	9909	broad.mit.edu	37	1	153907297	153907297	+	Silent	SNP	C	C	T	rs75341579	by1000genomes	TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr1:153907297C>T	uc001fdd.1	-	17	3113	c.2712G>A	c.(2710-2712)caG>caA	p.Q904Q		NM_014856	NP_055671	O75064	DEN4B_HUMAN	Homo sapiens DENN/MADD domain containing 4B (DENND4B), mRNA.	904	Gln-rich.									NS(1)|breast(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	36	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			gctgctgctgctgctgctgtt	0.632000													9	61					0	0	1	0	0
ZNF225	7768	broad.mit.edu	37	19	44622642	44622642	+	Silent	SNP	A	A	G	rs114271963	by1000genomes	TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr19:44622642A>G	uc002oyj.1	+	3	393	c.150A>G	c.(148-150)caA>caG	p.Q50Q	ZNF225_uc010ejf.1_Silent_p.Q50Q	NM_013362	NP_037494	Q9UK10	ZN225_HUMAN	Homo sapiens zinc finger protein 225 (ZNF225), mRNA.	50	KRAB.		Q -> R (in dbSNP:rs34863330).		regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|skin(1)|stomach(1)	16		Prostate(69;0.0352)|all_neural(266;0.202)				CAGGGCATCAATCACTCCACA	0.383000													40	51					0	0	1	0	0
RBL2	5934	broad.mit.edu	37	16	53514563	53514563	+	Missense_Mutation	SNP	G	G	A			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr16:53514563G>A	uc002ehi.4	+	19	3084	c.2966G>A	c.(2965-2967)cGc>cAc	p.R989H	RBL2_uc002ehj.3_Missense_Mutation_p.R699H|RBL2_uc010vgw.2_Intron	NM_005611	NP_005602	Q08999	RBL2_HUMAN	Homo sapiens retinoblastoma-like 2 (p130) (RBL2), mRNA.	989	Domain B.|Pocket; binds E1A.				cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			breast(3)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(8)|lung(17)|ovary(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45						ACACCTACTCGCCTCACAGGT	0.517000													55	158					0	0	1	0	0
TPCN1	53373	broad.mit.edu	37	12	113715129	113715129	+	Missense_Mutation	SNP	A	A	C			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr12:113715129A>C	uc001tux.3	+	12	1534	c.1360A>C	c.(1360-1362)Acc>Ccc	p.T454P	TPCN1_uc001tuw.3_Missense_Mutation_p.T382P|TPCN1_uc010syt.1_Missense_Mutation_p.T314P	NM_001143819	NP_060371	Q9ULQ1	TPC1_HUMAN	Homo sapiens two pore segment channel 1 (TPCN1), transcript variant 1, mRNA.	382						endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(2)|prostate(3)|skin(3)|urinary_tract(1)	40						GCGCTATCTTACCTTCAAGGC	0.577000													15	34					0	0	1	0	0
RRP7A	27341	broad.mit.edu	37	22	42912080	42912080	+	Missense_Mutation	SNP	C	C	A			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr22:42912080C>A	uc003bcp.3	-	0	842	c.348G>T	c.(346-348)aaG>aaT	p.K116N	RRP7A_uc003bcq.3_Missense_Mutation_p.K93N	NM_015703	NP_056518	Q9Y3A4	RRP7A_HUMAN	Homo sapiens ribosomal RNA processing 7 homolog A (S. cerevisiae) (RRP7A), mRNA.	93							RNA binding|nucleotide binding			central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|liver(2)|lung(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	10						CCAGGTCCGGCTTCTCCTGCA	0.617000													41	58					5.2432e-18	5.83591e-18	1	1	0
DNAJC16	23341	broad.mit.edu	37	1	15855696	15855696	+	Missense_Mutation	SNP	A	A	C			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr1:15855696A>C	uc001aws.3	+	1	216	c.96A>C	c.(94-96)agA>agC	p.R32S	DNAJC16_uc001awr.1_Missense_Mutation_p.R32S|DNAJC16_uc001awt.3_Intron	NM_015291	NP_056106	Q9Y2G8	DJC16_HUMAN	Homo sapiens DnaJ (Hsp40) homolog, subfamily C, member 16 (DNAJC16), mRNA.	32	J.				cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding	p.Y31H(1)		central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(4)|lung(7)|urinary_tract(1)	18		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		ACCCATACAGAGTCCTAGGGG	0.443000													32	57					0	0	1	0	0
ATP13A1	57130	broad.mit.edu	37	19	19758062	19758062	+	Missense_Mutation	SNP	T	T	C			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr19:19758062T>C	uc002nnh.4	-	21	3009	c.2981A>G	c.(2980-2982)aAt>aGt	p.N994S	ATP13A1_uc002nne.3_Missense_Mutation_p.N134S|ATP13A1_uc002nnf.4_Missense_Mutation_p.N362S|ATP13A1_uc002nng.3_Missense_Mutation_p.N876S	NM_020410	NP_065143	Q9HD20	AT131_HUMAN	Homo sapiens ATPase type 13A1 (ATP13A1), mRNA.	994					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding	p.N994D(1)		central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|liver(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29						GATGAGGGCATTGAGCGCCAG	0.632000													14	57					0	0	1	0	0
ATG2A	23130	broad.mit.edu	37	11	64681557	64681557	+	Missense_Mutation	SNP	C	C	A			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr11:64681557C>A	uc001obx.3	-	2	598	c.483G>T	c.(481-483)gaG>gaT	p.E161D	ATG2A_uc010rnt.1_Missense_Mutation_p.E161D	NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	Homo sapiens ATG2 autophagy related 2 homolog A (S. cerevisiae) (ATG2A), mRNA.	161							protein binding			breast(3)|central_nervous_system(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(19)|ovary(3)|prostate(5)|skin(1)|stomach(1)|urinary_tract(3)	55						GCTCACCAGTCTCAATGGTCT	0.667000													41	79					1.21353e-23	1.39939e-23	1	1	0
GLTSCR1	29998	broad.mit.edu	37	19	48183987	48183987	+	Silent	SNP	G	G	T			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr19:48183987G>T	uc002phh.4	+	5	1754	c.1560G>T	c.(1558-1560)ctG>ctT	p.L520L	GLTSCR1_uc002phi.4_Silent_p.L278L	NM_015711	NP_056526	Q9NZM4	GSCR1_HUMAN	Homo sapiens glioma tumor suppressor candidate region gene 1 (GLTSCR1), mRNA.	520							protein binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|pancreas(3)|prostate(4)|skin(2)	20		all_cancers(25;1.8e-07)|all_lung(116;5.73e-06)|Lung NSC(112;9.69e-06)|all_epithelial(76;2.42e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		all cancers(93;0.000358)|OV - Ovarian serous cystadenocarcinoma(262;0.000576)|Epithelial(262;0.0212)|GBM - Glioblastoma multiforme(486;0.0355)		ACCAGAACCTGGCGGGCCCAC	0.726000													31	46					1.04594e-18	1.18478e-18	1	1	0
EGFL7	51162	broad.mit.edu	37	9	139564703	139564703	+	Missense_Mutation	SNP	G	G	C			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr9:139564703G>C	uc004cid.3	+	6	1403	c.492G>C	c.(490-492)tgG>tgC	p.W164C	EGFL7_uc010nbp.3_Missense_Mutation_p.W164C|EGFL7_uc004cie.3_Missense_Mutation_p.W164C|EGFL7_uc004cif.3_Missense_Mutation_p.W164C|EGFL7_uc004cih.3_Missense_Mutation_p.W164C|MIR126_uc022bps.1_5'Flank	NM_201446	NP_958854	Q9UHF1	EGFL7_HUMAN	Homo sapiens EGF-like-domain, multiple 7 (EGFL7), transcript variant 2, mRNA.	164	EGF-like 2; calcium-binding (Potential).				angiogenesis|vasculogenesis		calcium ion binding			kidney(2)|ovary(1)|prostate(2)|urinary_tract(1)	6	all_cancers(76;0.109)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.87e-06)|Epithelial(140;0.000123)		GCCAGTGTTGGGAGGGGCACA	0.652000													36	94					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62271194	62271194	+	Missense_Mutation	SNP	A	A	G			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr1:62271194A>G	uc001dab.3	+	12	1738	c.1624A>G	c.(1624-1626)Atg>Gtg	p.M542V	INADL_uc009waf.1_Missense_Mutation_p.M542V|INADL_uc001daa.2_Missense_Mutation_p.M542V|INADL_uc001dad.3_Missense_Mutation_p.M239V|INADL_uc001dac.3_Non-coding_Transcript	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	Homo sapiens InaD-like (Drosophila) (INADL), mRNA.	542					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						TTATGAAGTAATGGTATGTTA	0.358000													18	31					0	0	1	0	0
ERCC6	2074	broad.mit.edu	37	10	50681040	50681040	+	Missense_Mutation	SNP	C	C	T			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr10:50681040C>T	uc001jhs.4	-	14	2898	c.2744G>A	c.(2743-2745)cGg>cAg	p.R915Q	ERCC6_uc009xod.3_Missense_Mutation_p.R75Q|ERCC6_uc010qgr.2_Missense_Mutation_p.R285Q|ERCC6_uc001jhr.4_Missense_Mutation_p.R283Q	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	Homo sapiens excision repair cross-complementing rodent repair deficiency, complementation group 6 (ERCC6), mRNA.	915	Helicase C-terminal.				base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|DNA binding|DNA-dependent ATPase activity|chromatin binding|helicase activity|protein C-terminus binding|protein N-terminus binding|protein complex binding			breast(5)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						GCCGCCCACCCGCGTGGTCAG	0.498000								Direct reversal of damage;Nucleotide excision repair (NER)					63	87					0	0	1	0	0
MUC2	4583	broad.mit.edu	37	11	1093376	1093376	+	Missense_Mutation	SNP	C	C	T			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr11:1093376C>T	uc001lsx.1	+	30	5222	c.5195C>T	c.(5194-5196)cCa>cTa	p.P1732L		NM_002457	NP_002448	Q02817	MUC2_HUMAN	Homo sapiens mucin 2, oligomeric mucus/gel-forming (MUC2), mRNA.	1793	Approximate repeats.					inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	acggtgaccccaaccccaaca	0.652000													4	73					0	0	1	0	0
RGPD4	285190	broad.mit.edu	37	2	108488583	108488583	+	Missense_Mutation	SNP	A	A	G			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr2:108488583A>G	uc010ywk.2	+	19	4205	c.4123A>G	c.(4123-4125)Aaa>Gaa	p.K1375E	RGPD4_uc002tdu.3_Missense_Mutation_p.K562E|RGPD4_uc010ywl.2_Intron	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	Homo sapiens RANBP2-like and GRIP domain containing 4 (RGPD4), mRNA.	1375	RanBD1 2.				intracellular transport		binding			breast(1)|endometrium(7)|kidney(4)|lung(23)|pancreas(1)|prostate(1)|skin(3)|urinary_tract(3)	43						TGGTCAATGGAAAGAAAGGGG	0.353000													149	45					0	0	1	0	0
KLHL11	55175	broad.mit.edu	37	17	40011371	40011371	+	Missense_Mutation	SNP	T	T	C			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr17:40011371T>C	uc002hyf.1	-	1	754	c.748A>G	c.(748-750)Aga>Gga	p.R250G		NM_018143	NP_060613	Q9NVR0	KLH11_HUMAN	Homo sapiens kelch-like 11 (Drosophila) (KLHL11), mRNA.	250	BACK.					extracellular region				NS(2)|breast(2)|endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	17		Breast(137;0.00156)				AGCCAGTCTCTAATGAGATGG	0.398000													23	22					0	0	1	0	0
MECR	51102	broad.mit.edu	37	1	29520638	29520638	+	Missense_Mutation	SNP	G	G	C			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr1:29520638G>C	uc001brq.1	-	9	1054	c.1018C>G	c.(1018-1020)Ctc>Gtc	p.L340V	MECR_uc001brp.1_Missense_Mutation_p.L264V	NM_016011	NP_001019903	Q9BV79	MECR_HUMAN	Homo sapiens mitochondrial trans-2-enoyl-CoA reductase (MECR), nuclear gene encoding mitochondrial protein, transcript variant 1, mRNA.	340					fatty acid biosynthetic process	mitochondrion	trans-2-enoyl-CoA reductase (NADPH) activity|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(1)|ovary(2)|prostate(1)	11		Colorectal(325;0.000389)|Breast(348;0.00765)|Lung NSC(340;0.0081)|all_lung(284;0.00914)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.39e-07)|COAD - Colon adenocarcinoma(152;2.04e-05)|STAD - Stomach adenocarcinoma(196;0.0195)|BRCA - Breast invasive adenocarcinoma(304;0.053)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.137)		GGGGCTGTGAGCTGGCCTCGG	0.572000													25	50					0	0	1	0	0
PAM	5066	broad.mit.edu	37	5	102285295	102285295	+	Missense_Mutation	SNP	C	C	T			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr5:102285295C>T	uc003knt.3	+	8	1071	c.698C>T	c.(697-699)gCc>gTc	p.A233V	PAM_uc003knw.3_Missense_Mutation_p.A233V|PAM_uc003kns.3_Missense_Mutation_p.A233V|PAM_uc003knu.3_Missense_Mutation_p.A233V|PAM_uc011cuz.2_Missense_Mutation_p.A136V|PAM_uc003knv.3_Missense_Mutation_p.A233V	NM_000919	NP_000910	P19021	AMD_HUMAN	Homo sapiens peptidylglycine alpha-amidating monooxygenase (PAM), transcript variant 1, mRNA.	233	Peptidylglycine alpha-hydroxylating monooxygenase (By similarity).				peptide metabolic process|protein modification process	extracellular region|integral to membrane|stored secretory granule	L-ascorbic acid binding|peptidylamidoglycolate lyase activity|peptidylglycine monooxygenase activity|protein binding			endometrium(2)|kidney(2)|large_intestine(10)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)	25		all_cancers(142;3.12e-07)|all_epithelial(76;3.48e-10)|Prostate(80;0.00914)|Lung NSC(167;0.0213)|Ovarian(225;0.024)|Colorectal(57;0.0251)|all_lung(232;0.0284)		Epithelial(69;1.1e-13)|COAD - Colon adenocarcinoma(37;0.0127)	Vitamin C(DB00126)	CATGTCTTTGCCTATAGAGTT	0.323000													17	167					0	0	1	0	0
C6orf10	10665	broad.mit.edu	37	6	32261299	32261299	+	Missense_Mutation	SNP	T	T	G			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr6:32261299T>G	uc021yvt.1	-	22	1324	c.1151A>C	c.(1150-1152)aAg>aCg	p.K384T	C6orf10_uc011dpx.2_Missense_Mutation_p.K375T|C6orf10_uc021yvs.1_Missense_Mutation_p.K301T|C6orf10_uc011dpz.2_Missense_Mutation_p.K382T|C6orf10_uc021yvu.1_Missense_Mutation_p.K382T|C6orf10_uc021yvv.1_Missense_Mutation_p.K368T	NM_006781	NP_006772	Q5SRN2	CF010_HUMAN	Homo sapiens chromosome 6 open reading frame 10 (C6orf10), mRNA.	384						integral to membrane				cervix(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(12)|ovary(1)|skin(1)	25						CTGACTCTTCTTTACTTGGGA	0.502000													38	54					0	0	1	0	0
CENPF	1063	broad.mit.edu	37	1	214813548	214813548	+	Nonsense_Mutation	SNP	A	A	T			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr1:214813548A>T	uc001hkm.3	+	11	2041	c.1867A>T	c.(1867-1869)Aaa>Taa	p.K623*		NM_016343	NP_057427	P49454	CENPF_HUMAN	Homo sapiens centromere protein F, 350/400kDa (mitosin) (CENPF), mRNA.	623					DNA replication|G2 phase of mitotic cell cycle|cell differentiation|cell division|cell proliferation|kinetochore assembly|metaphase plate congression|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|muscle organ development|negative regulation of transcription, DNA-dependent|protein transport|regulation of G2/M transition of mitotic cell cycle|regulation of striated muscle tissue development|response to drug	condensed chromosome outer kinetochore|cytosol|midbody|nuclear envelope|nuclear matrix|perinuclear region of cytoplasm|spindle pole	chromatin binding|dynein binding|protein C-terminus binding|protein homodimerization activity|transcription factor binding	p.W622*(1)		NS(2)|breast(2)|central_nervous_system(4)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(37)|lung(47)|ovary(7)|prostate(3)|skin(6)|stomach(1)|urinary_tract(1)	126				all cancers(67;0.00836)|OV - Ovarian serous cystadenocarcinoma(81;0.00855)|GBM - Glioblastoma multiforme(131;0.0694)|Epithelial(68;0.0833)		TTCTTGTTGGAAAAGTGAAAA	0.333000													18	26					0	0	1	0	0
DENND4B	9909	broad.mit.edu	37	1	153907294	153907294	+	Silent	SNP	C	C	T			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr1:153907294C>T	uc001fdd.1	-	17	3116	c.2715G>A	c.(2713-2715)caG>caA	p.Q905Q		NM_014856	NP_055671	O75064	DEN4B_HUMAN	Homo sapiens DENN/MADD domain containing 4B (DENND4B), mRNA.	905	Gln-rich.									NS(1)|breast(1)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(5)|skin(2)|urinary_tract(1)	36	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			gctgctgctgctgctgctgct	0.632000													4	67					0	0	1	0	0
FZD7	8324	broad.mit.edu	37	2	202900342	202900342	+	Nonsense_Mutation	SNP	C	C	G			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr2:202900342C>G	uc002uyw.1	+	0	1033	c.972C>G	c.(970-972)taC>taG	p.Y324*		NM_003507	NP_003498	O75084	FZD7_HUMAN	Homo sapiens frizzled family receptor 7 (FZD7), mRNA.	324					G-protein signaling, coupled to cGMP nucleotide second messenger|Wnt receptor signaling pathway, calcium modulating pathway|axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|gonad development|mesenchymal to epithelial transition|negative regulation of cell-substrate adhesion|negative regulation of ectodermal cell fate specification|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent|regulation of catenin import into nucleus|vasculature development	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			breast(1)|endometrium(6)|large_intestine(6)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	31						ACGATGGCTACCGCACGGTGG	0.632000											OREG0015146	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	54	123					0	0	1	0	0
FAM40B	57464	broad.mit.edu	37	7	129104562	129104562	+	Missense_Mutation	SNP	C	C	G			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr7:129104562C>G	uc011koy.2	+	15	1799	c.1759C>G	c.(1759-1761)Ctc>Gtc	p.L587V	FAM40B_uc003vow.3_Missense_Mutation_p.L587V|FAM40B_uc011koz.2_Missense_Mutation_p.L79V	NM_020704	NP_065755	Q9ULQ0	FA40B_HUMAN	Homo sapiens family with sequence similarity 40, member B (FAM40B), transcript variant 1, mRNA.	587										breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(5)|lung(13)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						ACACTTCAAACTCAACCATAT	0.478000													32	51					0	0	1	0	0
DUOX1	53905	broad.mit.edu	37	15	45427438	45427438	+	Silent	SNP	A	A	G			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr15:45427438A>G	uc001zus.1	+	5	790	c.444A>G	c.(442-444)agA>agG	p.R148R	DUOX1_uc001zut.1_Silent_p.R148R|DUOX1_uc010bee.1_5'UTR	NM_017434	NP_787954	Q9NRD9	DUOX1_HUMAN	Homo sapiens dual oxidase 1 (DUOX1), transcript variant 1, mRNA.	148	Peroxidase-like; mediates peroxidase activity.				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	NAD(P)H oxidase activity|NADP binding|calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|peroxidase activity			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(13)|lung(16)|ovary(6)|prostate(1)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)	57		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		CCTTCCAGAGAAGCCGCTGGG	0.721000													5	125					0	0	1	0	0
FAM65B	9750	broad.mit.edu	37	6	24843494	24843494	+	Missense_Mutation	SNP	C	C	G			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr6:24843494C>G	uc003neo.1	-	13	1692	c.1516G>C	c.(1516-1518)Gag>Cag	p.E506Q	FAM65B_uc011djs.1_Missense_Mutation_p.E485Q|FAM65B_uc011dju.2_Missense_Mutation_p.E490Q|FAM65B_uc003nep.3_Missense_Mutation_p.E456Q|FAM65B_uc011djt.2_Missense_Mutation_p.E456Q	NM_014722	NP_055537	Q9Y4F9	FA65B_HUMAN	Homo sapiens family with sequence similarity 65, member B (FAM65B), transcript variant 1, mRNA.	506					cell differentiation|muscle organ development	cytoskeleton|filopodium|mitochondrion	binding			breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)	25						CTGGGCTCCTCTGGGTCTTCC	0.577000													26	47					0	0	1	0	0
CCDC18	343099	broad.mit.edu	37	1	93705010	93705043	+	Splice_Site	DEL	TAGAAAAGAAAACAAATGCTGGTAAGCAAGTGGT	TAGAAAAGAAAACAAATGCTGGTAAGCAAGTGGT	-			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr1:93705010_93705043delTAGAAAAGAAAACAAATGCTGGTAAGCAAGTGGT	uc021opx.1	+	20	2928	c.2767_splice	c.e20+1	p.V923_splice	CCDC18_uc009wdl.1_Splice_Site_p.V558_splice	NM_206886	NP_996769	Q5T9S5	CCD18_HUMAN	Homo sapiens coiled-coil domain containing 18 (CCDC18), mRNA.	922										breast(5)|endometrium(3)|kidney(1)|large_intestine(6)|lung(19)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	42		all_lung(203;0.00196)|Lung NSC(277;0.00903)|Melanoma(281;0.099)|all_neural(321;0.185)|Glioma(108;0.203)		all cancers(265;0.00166)|GBM - Glioblastoma multiforme(16;0.00551)|Epithelial(280;0.0967)		AAGACAGAGCTAGAAAAGAAAACAAATGCTGGTAAGCAAGTGGTTAGATGAGTA	0.363													8	132	---	---	---	---					
YOD1	55432	broad.mit.edu	37	1	207222409	207222409	+	Frame_Shift_Del	DEL	C	C	-			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr1:207222409delC	uc001hfe.1	-	1	1050	c.1003delG	c.(1003-1005)gaafs	p.E335fs	PFKFB2_uc010psc.2_Intron|YOD1_uc001hff.1_Frame_Shift_Del_p.E291fs	NM_018566	NP_061036	Q5VVQ6	OTU1_HUMAN	Homo sapiens YOD1 OTU deubiquinating enzyme 1 homolog (S. cerevisiae) (YOD1), mRNA.	335					ER-associated protein catabolic process|cellular amino acid metabolic process|endoplasmic reticulum unfolded protein response|protein K48-linked deubiquitination|protein K63-linked deubiquitination	intracellular	protein binding|ubiquitin-specific protease activity|zinc ion binding			cervix(1)|endometrium(3)|large_intestine(1)|lung(3)|ovary(3)	11	Prostate(682;0.19)					TTGGCATGTTCCCTTGCTTCT	0.478													40	92	---	---	---	---					
TLR5	7100	broad.mit.edu	37	1	223285316	223285316	+	Frame_Shift_Del	DEL	C	C	-			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr1:223285316delC	uc021pjl.1	-	0	1058	c.1058delG	c.(1057-1059)agtfs	p.S353fs	TLR5_uc001hnv.2_Frame_Shift_Del_p.S353fs|TLR5_uc001hnw.2_Frame_Shift_Del_p.S353fs	NM_003268	NP_003259	O60602	TLR5_HUMAN	Homo sapiens toll-like receptor 5 (TLR5), mRNA.	353					MyD88-dependent toll-like receptor signaling pathway|cellular response to mechanical stimulus|inflammatory response|innate immune response|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(4)|lung(8)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				GBM - Glioblastoma multiforme(131;0.0851)		GAAATTCGAACTGTAAAGTTC	0.353													25	32	---	---	---	---					
ITPKB	3707	broad.mit.edu	37	1	226924770	226924784	+	In_Frame_Del	DEL	CTTCCTCTTGGCCTC	CTTCCTCTTGGCCTC	-	rs140396711	by1000genomes	TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr1:226924770_226924784delCTTCCTCTTGGCCTC	uc010pvo.2	-	1	716_730	c.376_390delGAGGCCAAGAGGAAG	c.(376-390)gaggccaagaggaagdel	p.EAKRK126del	ITPKB_uc001hqh.3_In_Frame_Del_p.EAKRK126del	NM_002221	NP_002212	P27987	IP3KB_HUMAN	Homo sapiens inositol-trisphosphate 3-kinase B (ITPKB), mRNA.	126							ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity	p.A127A(1)		central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(13)|ovary(4)|prostate(1)|skin(1)	30		Prostate(94;0.0773)				AGATCCGCAGCTTCCTCTTGGCCTCCTCCGGCCCT	0.656													17	61	---	---	---	---					
MYH15	22989	broad.mit.edu	37	3	108174686	108174687	+	Frame_Shift_Ins	INS	-	-	T			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr3:108174686_108174687insT	uc003dxa.1	-	20	2275_2276	c.2218_2219insA	c.(2218-2220)aggfs	p.R740fs		NM_014981	NP_055796	Q9Y2K3	MYH15_HUMAN	Homo sapiens myosin, heavy chain 15 (MYH15), mRNA.	740	Myosin head-like.					myofibril|myosin filament	ATP binding|actin binding|calmodulin binding|motor activity			NS(1)|breast(3)|central_nervous_system(2)|cervix(4)|endometrium(10)|kidney(4)|large_intestine(14)|lung(47)|ovary(5)|pancreas(2)|prostate(6)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	105						TGGAAAGGTCCTTGGATTCAGA	0.361													15	38	---	---	---	---					
KIAA1211	57482	broad.mit.edu	37	4	57180576	57180577	+	In_Frame_Ins	INS	-	-	GGAGCGGAGGGAGCGGAG	rs71921617	by1000genomes	TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr4:57180576_57180577insGGAGCGGAGGGAGCGGAG	uc003hbk.2	+	7	1299_1300	c.908_909insGGAGCGGAGGGAGCGGAG	c.(907-909)gcg>gcGGAGCGGAGGGAGCGGAGg	p.303_304insERRERR	KIAA1211_uc010iha.2_In_Frame_Ins_p.296_297insERRERR|KIAA1211_uc011bzz.1_In_Frame_Ins_p.213_214insERRERR|KIAA1211_uc003hbm.1_In_Frame_Ins_p.189_190insERRERR	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	Homo sapiens KIAA1211 (KIAA1211), mRNA.	303	Glu-rich.									endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					TGGGAGGACGCGGAGCGGAGGG	0.733													23	28	---	---	---	---					
PCDHB10	56126	broad.mit.edu	37	5	140574170	140574175	+	In_Frame_Del	DEL	AGGCCG	AGGCCG	-	rs58244182	byFrequency	TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr5:140574170_140574175delAGGCCG	uc003lix.3	+	0	2219_2224	c.2045_2050delAGGCCG	c.(2044-2052)caggccgag>cag	p.AE683del		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	Homo sapiens protocadherin beta 10 (PCDHB10), mRNA.	683					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(14)|lung(30)|ovary(4)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	76			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GCCCAGGCCCAGGCCGAGGCCGACTT	0.704													7	27	---	---	---	---					
RFX6	222546	broad.mit.edu	37	6	117203548	117203548	+	Frame_Shift_Del	DEL	C	C	-			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr6:117203548delC	uc003pxm.3	+	3	586	c.523delC	c.(523-525)cccfs	p.P175fs		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	Homo sapiens regulatory factor X, 6 (RFX6), mRNA.	175					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(29)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	59						CCAGAAGTTTCCCCTCCTAAC	0.413													35	42	---	---	---	---					
FOXE1	2304	broad.mit.edu	37	9	100616701	100616706	+	In_Frame_Del	DEL	GCCGCC	GCCGCC	-	rs11279082		TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr9:100616701_100616706delGCCGCC	uc004axu.3	+	0	1165_1170	c.505_510delGCCGCC	c.(505-510)gccgccdel	p.AA177del		NM_004473	NP_004464	O00358	FOXE1_HUMAN	Homo sapiens forkhead box E1 (thyroid transcription factor 2) (FOXE1), mRNA.	177	Ala-rich.|Poly-Ala.				cell migration|embryonic organ morphogenesis|hair follicle morphogenesis|hard palate development|lens morphogenesis in camera-type eye|negative regulation of transcription from RNA polymerase II promoter|pattern specification process|peripheral nervous system development|pharynx development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|soft palate development|thymus development|thyroid gland development|thyroid hormone generation	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			central_nervous_system(1)|endometrium(1)|lung(2)|upper_aerodigestive_tract(1)	5		Acute lymphoblastic leukemia(62;0.158)				Ggctgccgcagccgccgccgccgccg	0.767													3	5	---	---	---	---					
CCDC41	51134	broad.mit.edu	37	12	94763803	94763804	+	Frame_Shift_Ins	INS	-	-	T			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr12:94763803_94763804insT	uc001tdd.3	-	8	1528_1529	c.942_943insA	c.(940-945)gaacttfs	p.E314fs	CCDC41_uc001tde.3_Frame_Shift_Ins_p.E314fs|CCDC41_uc009zsw.1_Non-coding_Transcript|CCDC41_uc001tdf.3_Frame_Shift_Ins_p.E314fs	NM_016122	NP_057206	Q9Y592	CCD41_HUMAN	Homo sapiens coiled-coil domain containing 41 (CCDC41), transcript variant 1, mRNA.	306								p.E314*(1)		breast(1)|central_nervous_system(3)|kidney(3)|large_intestine(8)|lung(8)|prostate(2)|skin(2)	27						GAATGTTTAAGTTCTTTTACCT	0.332													21	37	---	---	---	---					
FAM59A	64762	broad.mit.edu	37	18	29867165	29867165	+	Frame_Shift_Del	DEL	A	A	-			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr18:29867165delA	uc002kxl.3	-	3	1451	c.1395delT	c.(1393-1395)catfs	p.H465fs	FAM59A_uc002kxk.2_Frame_Shift_Del_p.H465fs	NM_001242409	NP_001229338	Q9H706	FA59A_HUMAN	Homo sapiens family with sequence similarity 59, member A (FAM59A), transcript variant 1, mRNA.	465										endometrium(9)|kidney(3)|large_intestine(8)|lung(9)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	36						TGAGAGGCTGATGGCTGGGCT	0.527													27	41	---	---	---	---					
MICAL3	57553	broad.mit.edu	37	22	18300505	18300505	+	Frame_Shift_Del	DEL	T	T	-			TCGA-P4-A5E6-01A-11D-A28G-10	TCGA-P4-A5E6-11A-22D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8c543688-1b5c-4af6-806b-9c9e444a740f	5b0f01b3-0aee-4950-87e0-0a6c395d73a4	g.chr22:18300505delT	uc002zng.4	-	25	5275	c.4922delA	c.(4921-4923)cagfs	p.Q1641fs	MICAL3_uc011agl.2_Frame_Shift_Del_p.Q1557fs|MICAL3_uc010gre.2_5'Flank	NM_015241	NP_056056	Q7RTP6	MICA3_HUMAN	Homo sapiens microtubule associated monoxygenase, calponin and LIM domain containing 3 (MICAL3), transcript variant 1, mRNA.	1641						cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			large_intestine(1)|lung(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	4		all_epithelial(15;0.198)		Lung(27;0.0427)		CTCCTTGCCCTGGGAGGGTGC	0.711													12	17	---	---	---	---					
