Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SLC9A3	6550	broad.mit.edu	37	5	475168	475168	+	Silent	SNP	G	G	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr5:475168G>A	uc003jbe.2	-	15	2443	c.2331C>T	c.(2329-2331)ccC>ccT	p.P777P	SLC9A3_uc011clx.1_Silent_p.P768P|AK023178_uc021xvv.1_5'Flank|AK023178_uc003jbd.3_5'Flank	NM_004174	NP_004165	P48764	SL9A3_HUMAN	Homo sapiens solute carrier family 9 (sodium/hydrogen exchanger), member 3 (SLC9A3), mRNA.	777						cell surface|integral to membrane	sodium:hydrogen antiporter activity			NS(2)|biliary_tract(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(4)|liver(2)|lung(16)|prostate(3)|skin(2)|urinary_tract(1)	37			Epithelial(17;0.000529)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|all cancers(22;0.00186)|Lung(60;0.0863)			CCGTCTCCCCGGGAGACAGCC	0.677000													4	141					0	0	1	0	0
CAPN2	824	broad.mit.edu	37	1	223900400	223900400	+	Missense_Mutation	SNP	T	T	C			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr1:223900400T>C	uc001hob.4	+	0	282	c.58T>C	c.(58-60)Tcc>Ccc	p.S20P	CAPN2_uc010puy.2_Intron	NM_001748	NP_001139540	P17655	CAN2_HUMAN	Homo sapiens calpain 2, (m/II) large subunit (CAPN2), transcript variant 1, mRNA.	20					proteolysis	cytoplasm|plasma membrane				breast(3)|endometrium(1)|kidney(1)|large_intestine(9)|lung(10)|prostate(1)|skin(1)|stomach(3)	29				GBM - Glioblastoma multiforme(131;0.109)		GGGGCTGGGCTCCCACGACAG	0.711000													8	140					0	0	1	0	0
SCN9A	6335	broad.mit.edu	37	2	167055820	167055820	+	Missense_Mutation	SNP	C	C	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr2:167055820C>T	uc010fpl.3	-	26	5637	c.5296G>A	c.(5296-5298)Gat>Aat	p.D1766N	BC051759_uc002udp.3_Intron	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	Homo sapiens sodium channel, voltage-gated, type IX, alpha subunit (SCN9A), mRNA.	1777						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(5)|central_nervous_system(6)|endometrium(6)|kidney(3)|large_intestine(27)|lung(38)|ovary(6)|prostate(8)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	108					Lamotrigine(DB00555)|Lidocaine(DB00281)	TCAAAGTCATCCTCACTCAGA	0.428000													8	151					0	0	1	0	0
TGM7	116179	broad.mit.edu	37	15	43585145	43585145	+	Silent	SNP	C	C	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr15:43585145C>T	uc001zrf.1	-	2	206	c.201G>A	c.(199-201)aaG>aaA	p.K67K		NM_052955	NP_443187	Q96PF1	TGM7_HUMAN	Homo sapiens transglutaminase 7 (TGM7), mRNA.	67					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(2)|prostate(4)|skin(1)	39		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	GCTCTGACGGCTTGGGTCCTG	0.562000													14	38					0	0	1	0	0
HINFP	25988	broad.mit.edu	37	11	119001447	119001447	+	Missense_Mutation	SNP	C	C	G			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr11:119001447C>G	uc001pvp.3	+	3	438	c.194C>G	c.(193-195)tCc>tGc	p.S65C	HINFP_uc010rzb.2_Missense_Mutation_p.S65C|HINFP_uc021qrj.1_Missense_Mutation_p.S65C|HINFP_uc001pvq.3_Missense_Mutation_p.S65C|HINFP_uc001pvr.3_5'Flank	NM_015517	NP_945322	Q9BQA5	HINFP_HUMAN	Homo sapiens histone H4 transcription factor (HINFP), transcript variant 1, mRNA.	65					DNA damage checkpoint|DNA repair|establishment of protein localization|in utero embryonic development|myoblast differentiation|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	enzyme binding|histone binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(1)|pancreas(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23						GAAGAATTCTCCTGCTTGTGG	0.498000													41	67					0	0	1	0	0
FLJ36000	284124	broad.mit.edu	37	17	21904139	21904139	+	RNA	SNP	T	T	C			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr17:21904139T>C	uc002gza.2	+	0		c.78T>C								Homo sapiens uncharacterized FLJ36000 (FLJ36000), non-coding RNA.																		ccgagcaggatgaggaaacca	0.692000													9	87					0	0	1	0	0
SOST	50964	broad.mit.edu	37	17	41835944	41835944	+	Missense_Mutation	SNP	T	T	C			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr17:41835944T>C	uc002iec.1	-	0	213	c.166A>G	c.(166-168)Atg>Gtg	p.M56V		NM_025237	NP_079513	Q9BQB4	SOST_HUMAN	Homo sapiens sclerostin (SOST), mRNA.	56					Wnt receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of ossification|negative regulation of protein complex assembly		heparin binding|protein binding			large_intestine(2)|lung(3)|prostate(1)	6		Breast(137;0.00725)		UCEC - Uterine corpus endometrioid carcinoma (308;0.177)|BRCA - Breast invasive adenocarcinoma(366;0.0741)		GCCCGGTTCATGGTCTTGTTG	0.597000													20	51					0	0	1	0	0
KCNK15	60598	broad.mit.edu	37	20	43378866	43378866	+	Missense_Mutation	SNP	G	G	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr20:43378866G>T	uc002xmr.3	+	1	444	c.380G>T	c.(379-381)aGc>aTc	p.S127I		NM_022358	NP_071753	Q9H427	KCNKF_HUMAN	Homo sapiens potassium channel, subfamily K, member 15 (KCNK15), mRNA.	127						integral to membrane	potassium channel activity|voltage-gated ion channel activity	p.S127I(2)		NS(1)|endometrium(1)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(2)	10		Myeloproliferative disorder(115;0.0122)				ACTTTCCAGAGCCTGGGCGAA	0.672000													3	128					0.000602214	0.000649447	1	1	0
RBM19	9904	broad.mit.edu	37	12	114385205	114385205	+	Silent	SNP	G	G	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr12:114385205G>A	uc009zwi.2	-	10	1485	c.1341C>T	c.(1339-1341)ttC>ttT	p.F447F	RBM19_uc001tvn.4_Silent_p.F447F|RBM19_uc001tvm.3_Silent_p.F447F	NM_001146699	NP_057280	Q9Y4C8	RBM19_HUMAN	Homo sapiens RNA binding motif protein 19 (RBM19), transcript variant 1, mRNA.	447	RRM 3.				multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	RNA binding|nucleotide binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(10)|liver(1)|lung(22)|ovary(1)|skin(3)|stomach(4)	55	Medulloblastoma(191;0.163)|all_neural(191;0.178)					TGAAGGTGATGAATGCAAAAC	0.602000													50	169					0	0	1	0	0
KIR2DL2	3803	broad.mit.edu	37	GL000209.1	102226	102226	+	Missense_Mutation	SNP	T	T	G			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chrGL000209.1:102226T>G	uc021vdb.1	+	2	172	c.161T>G	c.(160-162)aTg>aGg	p.M54R	KIR2DL2_uc002qtt.2_Intron|KIR2DL2_uc002qty.3_Intron|KIR2DL2_uc010yie.2_Intron|KIR2DL2_uc002qul.2_Missense_Mutation_p.M54R	NM_014513	NP_055328	P43627	KI2L2_HUMAN	Homo sapiens killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5 (KIR2DS5), mRNA.	54	Ig-like C2-type 1.				regulation of immune response	integral to membrane|plasma membrane	receptor activity										TCAGATGTCATGTTTGAGCAC	0.522000													3	88					0	0	1	0	0
NUDT10	170685	broad.mit.edu	37	X	51076024	51076024	+	Silent	SNP	G	G	A	rs143435240	byFrequency	TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chrX:51076024G>A	uc004dph.3	+	1	427	c.207G>A	c.(205-207)gaG>gaA	p.E69E	NUDT10_uc004dpi.4_Silent_p.E69E	NM_153183	NP_694853	Q8NFP7	NUD10_HUMAN	Homo sapiens nudix (nucleoside diphosphate linked moiety X)-type motif 10 (NUDT10), mRNA.	69	Nudix hydrolase.					cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding	p.E69E(16)		cervix(1)|endometrium(8)|kidney(1)|large_intestine(1)|lung(1)|prostate(3)|upper_aerodigestive_tract(1)	16	Ovarian(276;0.236)					TGTACGAAGAGGCGGGAGTCA	0.657000													6	304					0	0	1	0	0
ROPN1B	152015	broad.mit.edu	37	3	125690910	125690910	+	Missense_Mutation	SNP	G	G	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr3:125690910G>T	uc003eih.3	+	1	241	c.13G>T	c.(13-15)Gat>Tat	p.D5Y	ROPN1B_uc010hsb.3_Missense_Mutation_p.D5Y|ROPN1B_uc011bkg.2_Missense_Mutation_p.D5Y	NM_001012337	NP_001012337	Q9BZX4	ROP1B_HUMAN	Homo sapiens rhophilin associated tail protein 1B (ROPN1B), mRNA.	5					Rho protein signal transduction|acrosome reaction|cell-cell adhesion|cytokinesis|fusion of sperm to egg plasma membrane|sperm motility|spermatogenesis	cytoplasm|flagellum	cAMP-dependent protein kinase regulator activity|protein heterodimerization activity|protein homodimerization activity|receptor signaling complex scaffold activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|stomach(1)	8				GBM - Glioblastoma multiforme(114;0.151)		GGCTCAGACAGATAAGCCAAC	0.517000													21	48					4.26978e-12	4.99655e-12	1	1	0
UTS2R	2837	broad.mit.edu	37	17	80333066	80333066	+	Missense_Mutation	SNP	C	C	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr17:80333066C>A	uc010wvl.2	+	0	866	c.866C>A	c.(865-867)gCg>gAg	p.A289E		NM_018949	NP_061822	Q9UKP6	UR2R_HUMAN	Homo sapiens urotensin 2 receptor (UTS2R), mRNA.	289						integral to membrane|plasma membrane				breast(1)|endometrium(4)|kidney(1)|lung(2)	8	Breast(20;0.00106)|all_neural(118;0.0804)		OV - Ovarian serous cystadenocarcinoma(97;0.00928)|BRCA - Breast invasive adenocarcinoma(99;0.0833)			GCCCCGCTGGCGCCGCGGACG	0.672000													10	135					2.32078e-09	2.67783e-09	1	1	0
TTC25	83538	broad.mit.edu	37	17	40113444	40113444	+	Missense_Mutation	SNP	A	A	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr17:40113444A>T	uc002hyj.4	+	9	1382	c.1293A>T	c.(1291-1293)aaA>aaT	p.K431N		NM_031421	NP_113609	Q96NG3	TTC25_HUMAN	Homo sapiens tetratricopeptide repeat domain 25 (TTC25), mRNA.	466						cytoplasm	protein binding			endometrium(2)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(1)	12		all_cancers(22;8.16e-06)|Breast(137;0.000143)|all_epithelial(22;0.000236)				AACTGAGGAAAACCAACTACG	0.468000													48	66					0	0	1	0	0
ATP10D	57205	broad.mit.edu	37	4	47593174	47593174	+	Missense_Mutation	SNP	G	G	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr4:47593174G>T	uc003gxk.1	+	22	4221	c.4057G>T	c.(4057-4059)Gct>Tct	p.A1353S	ATP10D_uc003gxl.1_Missense_Mutation_p.A601S	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	Homo sapiens ATPase, class V, type 10D (ATP10D), mRNA.	1353					ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			NS(2)|endometrium(5)|kidney(5)|large_intestine(14)|liver(2)|lung(26)|ovary(2)|pancreas(1)|prostate(5)|skin(2)|stomach(1)|urinary_tract(1)	66						GTGGAGAGGGGCTGGAAAGAT	0.468000													3	69					0.00909568	0.00962043	1	1	0
PPP2R2C	5522	broad.mit.edu	37	4	6335365	6335365	+	Missense_Mutation	SNP	T	T	C			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr4:6335365T>C	uc003gja.3	-	6	908	c.884A>G	c.(883-885)tAc>tGc	p.Y295C	PPP2R2C_uc003gjb.3_Missense_Mutation_p.Y278C|PPP2R2C_uc003gjc.3_Missense_Mutation_p.Y295C|PPP2R2C_uc011bwd.2_Missense_Mutation_p.Y288C|PPP2R2C_uc011bwe.2_Missense_Mutation_p.Y288C|PPP2R2C_uc003gjd.1_Missense_Mutation_p.Y383C	NM_181876	NP_870991	Q9Y2T4	2ABG_HUMAN	Homo sapiens protein phosphatase 2, regulatory subunit B, gamma (PPP2R2C), transcript variant 2, mRNA.	295					signal transduction	protein phosphatase type 2A complex	protein phosphatase type 2A regulator activity			central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(7)|ovary(2)|prostate(2)|skin(3)|urinary_tract(1)	28						GGTGAGCATGTAGCGGCCGCT	0.572000											OREG0016071	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	58	39					0	0	1	0	0
N6AMT2	221143	broad.mit.edu	37	13	21306119	21306119	+	Silent	SNP	T	T	C			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr13:21306119T>C	uc001uno.1	-	3	450	c.369A>G	c.(367-369)ccA>ccG	p.P123P	N6AMT2_uc009zzr.1_Silent_p.P123P|N6AMT2_uc001unp.2_Non-coding_Transcript	NM_174928	NP_777588	Q8WVE0	N6MT2_HUMAN	Homo sapiens N-6 adenine-specific DNA methyltransferase 2 (putative) (N6AMT2), mRNA.	123							methyltransferase activity|nucleic acid binding			endometrium(1)|large_intestine(3)|lung(3)	7		all_cancers(29;5.91e-19)|all_epithelial(30;1.42e-15)|all_lung(29;5.9e-14)|Lung SC(185;0.0367)		all cancers(112;0.000234)|Epithelial(112;0.000471)|OV - Ovarian serous cystadenocarcinoma(117;0.0111)|Lung(94;0.0161)|LUSC - Lung squamous cell carcinoma(192;0.0431)		GTAAGTCCAATGGATTATTGT	0.378000													30	37					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195512487	195512487	+	Silent	SNP	G	G	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr3:195512487G>A	uc021xjp.1	-	1	6120	c.5964C>T	c.(5962-5964)acC>acT	p.T1988T	MUC4_uc003fvo.3_Intron|MUC4_uc003fvp.3_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	Homo sapiens mucin 4, cell surface associated (MUC4), transcript variant 1, mRNA.	760					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGGAAGCGTCGGTGACAGGAA	0.607000													8	294					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195509340	195509340	+	Silent	SNP	G	G	A	rs71291868		TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr3:195509340G>A	uc021xjp.1	-	1	9267	c.9111C>T	c.(9109-9111)caC>caT	p.H3037H	MUC4_uc021xjm.1_5'Flank|MUC4_uc021xjn.1_5'Flank|MUC4_uc021xjo.1_5'Flank|MUC4_uc021xjg.1_5'Flank|MUC4_uc021xjh.1_5'Flank|MUC4_uc021xji.1_5'Flank|MUC4_uc021xjj.1_5'Flank|MUC4_uc021xjk.1_5'Flank|MUC4_uc021xjl.1_5'Flank|MUC4_uc003fvo.3_Intron|MUC4_uc003fvp.3_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	Homo sapiens mucin 4, cell surface associated (MUC4), transcript variant 1, mRNA.	785					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GCGGGGTGGCGTGACCGGTGG	0.602000													7	452					0	0	1	0	0
ARFGAP1	55738	broad.mit.edu	37	20	61918934	61918934	+	Missense_Mutation	SNP	T	T	G			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr20:61918934T>G	uc002yem.3	+	12	1042	c.930T>G	c.(928-930)agT>agG	p.S310R	ARFGAP1_uc011aas.1_Missense_Mutation_p.S265R|ARFGAP1_uc011aat.1_Missense_Mutation_p.S197R|ARFGAP1_uc002yel.3_Missense_Mutation_p.S318R|ARFGAP1_uc002yen.3_Missense_Mutation_p.V390G|ARFGAP1_uc002yeo.1_Non-coding_Transcript	NM_018209	NP_060679	Q8N6T3	ARFG1_HUMAN	Homo sapiens ADP-ribosylation factor GTPase activating protein 1 (ARFGAP1), transcript variant 1, mRNA.	310					COPI coating of Golgi vesicle|protein transport|regulation of ARF GTPase activity|retrograde vesicle-mediated transport, Golgi to ER	Golgi-associated vesicle membrane|cytosol	ARF GTPase activator activity|zinc ion binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|ovary(1)|pancreas(1)	13	all_cancers(38;1.59e-09)					AGGGCCACAGTTATCAGAACA	0.542000													23	39					0	0	1	0	0
C10orf129	142827	broad.mit.edu	37	10	96967018	96967018	+	Missense_Mutation	SNP	C	C	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr10:96967018C>A	uc001kke.3	+	3	582	c.457C>A	c.(457-459)Caa>Aaa	p.Q153K	C10orf129_uc009xuu.1_Missense_Mutation_p.Q63K	NM_207321	NP_997204	Q6P461	ACSM6_HUMAN	Homo sapiens chromosome 10 open reading frame 129 (C10orf129), mRNA.	153					fatty acid metabolic process	mitochondrion	ATP binding|GTP binding|butyrate-CoA ligase activity|metal ion binding			breast(1)|kidney(2)|lung(1)|pancreas(1)|prostate(1)|skin(1)	7		Colorectal(252;0.083)		Epithelial(162;1.64e-06)|all cancers(201;3.71e-05)		AATTCGCTATCAATTACGCAT	0.468000													17	57					5.35267e-07	6.04925e-07	1	1	0
TET1	80312	broad.mit.edu	37	10	70404893	70404893	+	Missense_Mutation	SNP	G	G	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr10:70404893G>T	uc001jok.4	+	3	2912	c.2407G>T	c.(2407-2409)Gct>Tct	p.A803S		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	Homo sapiens tet methylcytosine dioxygenase 1 (TET1), mRNA.	803					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding	p.A803T(1)		breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(2)|ovary(5)|prostate(1)|upper_aerodigestive_tract(2)	21						CCATAAAAACGCTATGAGCTC	0.353000													9	59					7.48243e-07	8.39864e-07	1	1	0
AGAP3	116988	broad.mit.edu	37	7	150839014	150839014	+	Missense_Mutation	SNP	G	G	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr7:150839014G>A	uc003wjg.1	+	13	1837	c.1834G>A	c.(1834-1836)Gtg>Atg	p.V612M	AGAP3_uc003wje.1_Missense_Mutation_p.V281M|AGAP3_uc003wjj.1_Missense_Mutation_p.V111M|AGAP3_uc003wjk.1_Missense_Mutation_p.V30M	NM_031946	NP_114152	Q96P47	AGAP3_HUMAN	Homo sapiens ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 (AGAP3), transcript variant 1, mRNA.	576					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(3)|liver(2)|lung(9)|ovary(2)|prostate(3)|urinary_tract(1)	28						ATTTGTGGTGGTGTCCCTCAC	0.612000													95	161					0	0	1	0	0
RRN3	54700	broad.mit.edu	37	16	15188060	15188060	+	Missense_Mutation	SNP	G	G	A	rs139679899	by1000genomes	TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr16:15188060G>A	uc002dde.3	-	0	99	c.31C>T	c.(31-33)Ccg>Tcg	p.P11S	PDXDC1_uc002ddc.3_Intron|RRN3_uc010uzq.2_Missense_Mutation_p.P11S|RRN3_uc002ddf.1_Missense_Mutation_p.P11S	NM_018427	NP_060897	Q9NYV6	RRN3_HUMAN	Homo sapiens RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) (RRN3), mRNA.	11					regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm		p.P11S(6)		NS(2)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|prostate(2)	20						GCATCTCCCGGCAAACGCGTG	0.637000													4	136					0	0	1	0	0
OPN1SW	611	broad.mit.edu	37	7	128415147	128415147	+	Silent	SNP	C	C	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr7:128415147C>T	uc003vnt.4	-	1	414	c.414G>A	c.(412-414)aaG>aaA	p.K138K		NM_001708	NP_001699	P03999	OPSB_HUMAN	Homo sapiens opsin 1 (cone pigments), short-wave-sensitive (OPN1SW), mRNA.	138					phototransduction|protein-chromophore linkage|visual perception	integral to plasma membrane	G-protein coupled receptor activity|photoreceptor activity			NS(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(10)|stomach(1)	19						TGCCGAAGGGCTTACAGATGA	0.547000													43	110					0	0	1	0	0
IQCA1	79781	broad.mit.edu	37	2	237272540	237272540	+	Silent	SNP	C	C	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr2:237272540C>T	uc002vwb.2	-	14	1810	c.1776G>A	c.(1774-1776)ctG>ctA	p.L592L	IQCA1_uc002vvz.1_Silent_p.L584L|IQCA1_uc002vwa.1_Non-coding_Transcript|IQCA1_uc010zni.1_Silent_p.L543L	NM_024726	NP_079002	Q86XH1	IQCA1_HUMAN	Homo sapiens IQ motif containing with AAA domain 1 (IQCA1), mRNA.	584							ATP binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(1)	26						TGGCATGGACCAGCATTTTCT	0.512000													80	68					0	0	1	0	0
HYDIN	54768	broad.mit.edu	37	GL000192.1	160042	160042	+	RNA	SNP	G	G	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chrGL000192.1:160042G>A	uc010yih.1	-	11		c.2380C>T						Q4G0P3	HYDIN_HUMAN	Homo sapiens mRNA for KIAA1864 protein, partial cds.											breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(17)|lung(12)|ovary(2)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)	43		Ovarian(137;0.0654)				cagtcgctccgctcctccagg	0.652000													8	25					0	0	1	0	0
TUBB	203068	broad.mit.edu	37	6	30692075	30692075	+	Missense_Mutation	SNP	G	G	C			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr6:30692075G>C	uc003nrl.3	+	3	1363	c.1236G>C	c.(1234-1236)gaG>gaC	p.E412D	TUBB_uc011dmq.2_Missense_Mutation_p.E340D	NM_178014	NP_821133	P07437	TBB5_HUMAN	Homo sapiens tubulin, beta class I (TUBB), mRNA.	412					G2/M transition of mitotic cell cycle|cellular component movement|microtubule-based movement|natural killer cell mediated cytotoxicity|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|MHC class I protein binding			breast(1)|endometrium(1)|kidney(8)|large_intestine(3)|lung(1)|ovary(1)|urinary_tract(1)	16					Colchicine(DB01394)|Vinblastine(DB00570)|Vincristine(DB00541)|Vinorelbine(DB00361)	CCGAGGCTGAGAGCAACATGA	0.587000													4	111					0	0	1	0	0
DGKG	1608	broad.mit.edu	37	3	185960324	185960324	+	Nonsense_Mutation	SNP	T	T	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr3:185960324T>A	uc003fqa.3	-	19	2332	c.1795A>T	c.(1795-1797)Aga>Tga	p.R599*	DGKG_uc003fqb.3_Nonsense_Mutation_p.R560*|DGKG_uc003fqc.3_Nonsense_Mutation_p.R574*|DGKG_uc011brx.2_Nonsense_Mutation_p.R540*	NM_001346	NP_001337	P49619	DGKG_HUMAN	Homo sapiens diacylglycerol kinase, gamma 90kDa (DGKG), transcript variant 1, mRNA.	599					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(3)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	42	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	TGTTTCTCTCTCATCACATGG	0.547000											OREG0015965	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	61					0	0	1	0	0
GIGYF2	26058	broad.mit.edu	37	2	233671361	233671361	+	Silent	SNP	T	T	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr2:233671361T>A	uc002vtj.4	+	16	2130	c.1863T>A	c.(1861-1863)ccT>ccA	p.P621P	GIGYF2_uc010zmj.1_Silent_p.P600P|GIGYF2_uc002vtg.2_Silent_p.P594P|GIGYF2_uc002vti.4_Silent_p.P600P|GIGYF2_uc002vtk.4_Silent_p.P600P|GIGYF2_uc002vth.4_Silent_p.P594P|GIGYF2_uc010zmk.2_Non-coding_Transcript|GIGYF2_uc010zml.1_Silent_p.P431P	NM_001103147	NP_001096617	Q6Y7W6	PERQ2_HUMAN	Homo sapiens GRB10 interacting GYF protein 2 (GIGYF2), transcript variant 1, mRNA.	600	Gln-rich.				cell death		protein binding			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(17)|lung(11)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	63		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		CTCCCCCTCCTCATATGGTAA	0.433000													32	16					0	0	1	0	0
PRPS2	5634	broad.mit.edu	37	X	12840843	12840843	+	Missense_Mutation	SNP	C	C	G			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chrX:12840843C>G	uc004cva.3	+	6	1037	c.894C>G	c.(892-894)atC>atG	p.I298M	PRPS2_uc004cvb.3_Missense_Mutation_p.I295M|PRPS2_uc010nec.3_Missense_Mutation_p.I173M	NM_001039091	NP_001034180	P11908	PRPS2_HUMAN	Homo sapiens phosphoribosyl pyrophosphate synthetase 2 (PRPS2), transcript variant 1, mRNA.	295					nucleoside metabolic process|ribonucleoside monophosphate biosynthetic process		ATP binding|kinase activity|magnesium ion binding|protein homodimerization activity|ribose phosphate diphosphokinase activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(5)|urinary_tract(1)	16						TTTCCATGATCTTGGCCGAAG	0.453000													50	127					0	0	1	0	0
METAP2	10988	broad.mit.edu	37	12	95867964	95867964	+	Silent	SNP	T	T	G			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr12:95867964T>G	uc001tec.3	+	0	143	c.9T>G	c.(7-9)ggT>ggG	p.G3G	METAP2_uc010suv.2_Silent_p.G3G|METAP2_uc001tef.3_Silent_p.G3G|METAP2_uc001tee.3_Non-coding_Transcript	NM_006838	NP_006829	P50579	AMPM2_HUMAN	Homo sapiens methionyl aminopeptidase 2 (METAP2), mRNA.	3					N-terminal protein amino acid modification|peptidyl-methionine modification|protein processing|proteolysis	cytoplasm	aminopeptidase activity|metal ion binding|metalloexopeptidase activity			endometrium(3)|large_intestine(2)|lung(7)|prostate(1)	13					L-Methionine(DB00134)	ACATGGCGGGTGTGGAGGAGG	0.652000													6	114					0	0	1	0	0
MLL	4297	broad.mit.edu	37	11	118373932	118373932	+	Missense_Mutation	SNP	A	A	C			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr11:118373932A>C	uc001pta.3	+	26	7339	c.7316A>C	c.(7315-7317)gAa>gCa	p.E2439A	MLL_uc001ptb.3_Missense_Mutation_p.E2442A	NM_005933	NP_005924	Q03164	MLL1_HUMAN	Homo sapiens myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) (MLL), transcript variant 2, mRNA.	2439					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			breast(5)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(29)|lung(34)|ovary(6)|pancreas(3)|prostate(8)|skin(6)|urinary_tract(19)	131	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		ACTTTCAAAGAAAAGCATTCC	0.403000			"""T, O"""	"""MLL, MLLT1, MLLT2, MLLT3, MLLT4, MLLT7, MLLT10, MLLT6, ELL, EPS15, AF1Q, CREBBP, SH3GL1, FNBP1, PNUTL1, MSF, GPHN, GMPS, SSH3BP1, ARHGEF12, GAS7, FOXO3A, LAF4, LCX, SEPT6, LPP, CBFA2T1, GRAF, EP300, PICALM, HEAB"""	"""AML, ALL"""								29	44					0	0	1	0	0
FAM194A	131831	broad.mit.edu	37	3	150421590	150421590	+	Silent	SNP	T	T	C			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr3:150421590T>C	uc003eyg.3	-	0	153	c.96A>G	c.(94-96)gaA>gaG	p.E32E	FAM194A_uc003eyh.3_5'UTR	NM_152394	NP_689607	Q7L0X2	F194A_HUMAN	Homo sapiens family with sequence similarity 194, member A (FAM194A), mRNA.	32	Glu-rich.									NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(3)|kidney(1)|large_intestine(10)|lung(14)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	38						cctccacctcttcctcctcct	0.632000													5	90					0	0	1	0	0
CSPG4	1464	broad.mit.edu	37	15	75982866	75982866	+	Silent	SNP	G	G	C			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr15:75982866G>C	uc002baw.3	-	2	633	c.540C>G	c.(538-540)ctC>ctG	p.L180L		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	Homo sapiens chondroitin sulfate proteoglycan 4 (CSPG4), mRNA.	180	Globular or compact configuration stabilized by disulfide bonds.|Laminin G-like 1.|Neurite growth inhibition (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						GAGGCCGGAGGAGGCTGCGGC	0.647000													16	40					0	0	1	0	0
ESRP2	80004	broad.mit.edu	37	16	68267896	68267896	+	Splice_Site	SNP	C	C	G			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr16:68267896C>G	uc010cfa.1	-	3	629	c.441_splice	c.e3+1	p.K147_splice	ESRP2_uc002evp.1_5'Flank|ESRP2_uc002evq.1_Splice_Site_p.K147_splice	NM_024939	NP_079215	Q9H6T0	ESRP2_HUMAN	Homo sapiens epithelial splicing regulatory protein 2 (ESRP2), mRNA.	147					RNA splicing|mRNA processing|regulation of RNA splicing	nucleus	mRNA binding|nucleotide binding			NS(1)|central_nervous_system(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(1)|prostate(2)	16						CAGGAGCATACCTTCCTGGAG	0.617000													23	55					0	0	1	0	0
MST1P2	11209	broad.mit.edu	37	1	16975411	16975411	+	RNA	SNP	G	G	C			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr1:16975411G>C	uc010och.2	+	8		c.1692G>C			MST1P2_uc009vox.3_Non-coding_Transcript|MST1P2_uc001azm.4_Non-coding_Transcript					Homo sapiens macrophage stimulating 1 (hepatocyte growth factor-like) pseudogene 2 (MST1P2), non-coding RNA.																		CAAGAGGGTGGATCGGCTGGA	0.597000													10	426					0	0	1	0	0
RRN3	54700	broad.mit.edu	37	16	15188066	15188066	+	Missense_Mutation	SNP	G	G	A	rs142601938	by1000genomes	TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr16:15188066G>A	uc002dde.3	-	0	93	c.25C>T	c.(25-27)Cgt>Tgt	p.R9C	PDXDC1_uc002ddc.3_Intron|RRN3_uc010uzq.2_Missense_Mutation_p.R9C|RRN3_uc002ddf.1_Missense_Mutation_p.R9C	NM_018427	NP_060897	Q9NYV6	RRN3_HUMAN	Homo sapiens RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) (RRN3), mRNA.	9					regulation of transcription, DNA-dependent|transcription initiation from RNA polymerase I promoter	nucleolus|nucleoplasm		p.R9C(6)		NS(2)|central_nervous_system(3)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|prostate(2)	20						CCCGGCAAACGCGTGTGAAGC	0.642000													4	129					0	0	1	0	0
CR1	1378	broad.mit.edu	37	1	207787753	207787753	+	Nonsense_Mutation	SNP	C	C	T	rs55749440		TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr1:207787753C>T	uc001hfy.3	+	31	5370	c.5230C>T	c.(5230-5232)Cga>Tga	p.R1744*	CR1_uc001hfx.3_Nonsense_Mutation_p.R2194*|CR1_uc021pij.1_Nonsense_Mutation_p.R1744*	NM_000573	NP_000564	P17927	CR1_HUMAN	Homo sapiens complement component (3b/4b) receptor 1 (Knops blood group) (CR1), transcript variant F, mRNA.	1744	Sushi 27.				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity	p.R1749*(9)|p.R2194*(9)|p.R1744*(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(9)|kidney(11)|large_intestine(13)|lung(33)|ovary(3)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	82						CTTTAGGTTCCGATTAAAAGG	0.423000													3	152					0	0	1	0	0
DDN	23109	broad.mit.edu	37	12	49391677	49391677	+	Missense_Mutation	SNP	C	C	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr12:49391677C>T	uc001rsv.1	-	1	1000	c.982G>A	c.(982-984)Ggt>Agt	p.G328S		NM_015086	NP_055901	O94850	DEND_HUMAN	Homo sapiens dendrin (DDN), mRNA.	328						dendritic spine membrane|endoplasmic reticulum membrane|nucleus|perikaryon				NS(1)|kidney(1)|large_intestine(1)|lung(3)|prostate(1)|stomach(1)	8						CTGTCGCTACCACTGTTCAGG	0.677000													10	36					0	0	1	0	0
KLRK1	22914	broad.mit.edu	37	12	10539523	10539523	+	Missense_Mutation	SNP	T	T	C			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr12:10539523T>C	uc009zhj.3	-	2	304	c.127A>G	c.(127-129)Aaa>Gaa	p.K43E	AK096314_uc001qya.1_Intron|KLRK1_uc001qyb.3_Non-coding_Transcript|KLRK1_uc001qyc.3_Missense_Mutation_p.K43E|KLRK1_uc009zhk.3_Missense_Mutation_p.K43E|KLRK1_uc001qyd.3_Missense_Mutation_p.K43E	NM_007360	NP_001186734	P26718	NKG2D_HUMAN	Homo sapiens killer cell lectin-like receptor subfamily K, member 1 (KLRK1), mRNA.	43					T cell costimulation|natural killer cell activation	integral to plasma membrane	sugar binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(3)|skin(1)	9						CATTTGCTTTTGACTACTGGA	0.323000													25	39					0	0	1	0	0
BC070322	0	broad.mit.edu	37	9	69634792	69634792	+	RNA	SNP	G	G	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr9:69634792G>T	uc004afu.3	-	2		c.279C>A								Homo sapiens aquaporin 7 pseudogene 2, mRNA (cDNA clone IMAGE:30406582).																		TGTTCTCCTGGTCCACGATGG	0.587000													9	9					0.000442599	0.000480453	1	1	0
PTPRG	5793	broad.mit.edu	37	3	62189090	62189090	+	Missense_Mutation	SNP	G	G	C			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr3:62189090G>C	uc003dlb.3	+	11	2340	c.1621G>C	c.(1621-1623)Gcc>Ccc	p.A541P	PTPRG_uc003dlc.3_Missense_Mutation_p.A541P	NM_002841	NP_002832	P23470	PTPRG_HUMAN	Homo sapiens protein tyrosine phosphatase, receptor type, G (PTPRG), mRNA.	541					transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|liver(2)|lung(15)|ovary(7)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	62				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		CCTCCCGACGGCCGCCTCAGC	0.687000													54	27					0	0	1	0	0
PRRT2	112476	broad.mit.edu	37	16	29825753	29825753	+	Missense_Mutation	SNP	A	A	C			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr16:29825753A>C	uc002dud.2	+	2	1280	c.979A>C	c.(979-981)Atc>Ctc	p.I327L	BOLA2_uc010bzb.1_Intron|AK097472_uc002duc.1_5'Flank|PRRT2_uc002due.4_Missense_Mutation_p.I327L|PRRT2_uc002duf.1_3'UTR|C16orf53_uc002dug.4_5'Flank	NM_145239	NP_660282	Q7Z6L0	PRRT2_HUMAN	Homo sapiens proline-rich transmembrane protein 2 (PRRT2), transcript variant 1, mRNA.	327					response to biotic stimulus	integral to membrane		p.I327I(1)		central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	8						GGGAGTCCTCATCATCATCGC	0.642000													15	33					0	0	1	0	0
MUC20	200958	broad.mit.edu	37	3	195447900	195447900	+	Missense_Mutation	SNP	G	G	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr3:195447900G>A	uc010hzo.3	+	0	148	c.22G>A	c.(22-24)Gct>Act	p.A8T		NM_152673	NP_689886	Q8N307	MUC20_HUMAN	Homo sapiens mucin 20, cell surface associated (MUC20), transcript variant L, mRNA.	8					protein homooligomerization	apical plasma membrane|basal plasma membrane|extracellular region|microvillus membrane				NS(1)|breast(1)|endometrium(3)|kidney(3)|large_intestine(3)|lung(4)|skin(4)|stomach(3)|upper_aerodigestive_tract(1)	23	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)	Lung NSC(153;0.191)	Epithelial(36;1e-21)|all cancers(36;9.02e-20)|OV - Ovarian serous cystadenocarcinoma(49;1.6e-18)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;1.66e-05)		CTGGGGTCTGGCTCTGCCCCT	0.622000													4	62					0	0	1	0	0
PHKA2	5256	broad.mit.edu	37	X	18919658	18919658	+	Missense_Mutation	SNP	C	C	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chrX:18919658C>A	uc004cyv.4	-	26	3402	c.2972G>T	c.(2971-2973)gGa>gTa	p.G991V	PHKA2_uc010nfe.1_Missense_Mutation_p.G41V|PHKA2_uc010nff.1_Intron	NM_000292	NP_000283	P46019	KPB2_HUMAN	Homo sapiens phosphorylase kinase, alpha 2 (liver) (PHKA2), mRNA.	991					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			NS(1)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(12)|lung(23)|ovary(2)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	61	Hepatocellular(33;0.183)					TTTGGTGACTCCGGTATGGCC	0.547000													52	102					1.08141e-31	1.29299e-31	1	1	0
MAN2B1	4125	broad.mit.edu	37	19	12760979	12760979	+	Missense_Mutation	SNP	G	G	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr19:12760979G>A	uc002mub.2	-	16	2180	c.2104C>T	c.(2104-2106)Cgc>Tgc	p.R702C	MAN2B1_uc010dyv.1_Missense_Mutation_p.R701C	NM_000528	NP_000519	O00754	MA2B1_HUMAN	Homo sapiens mannosidase, alpha, class 2B, member 1 (MAN2B1), transcript variant 1, mRNA.	702					protein deglycosylation	lysosome	alpha-mannosidase activity|zinc ion binding			breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(10)|ovary(4)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	33						GGGTACAGGCGAACCACCTGG	0.627000													6	129					0	0	1	0	0
BRI3BP	140707	broad.mit.edu	37	12	125509640	125509640	+	Silent	SNP	C	C	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr12:125509640C>A	uc001uha.1	+	2	563	c.420C>A	c.(418-420)tcC>tcA	p.S140S	DL490908_uc021rgk.1_5'Flank	NM_080626	NP_542193	Q8WY22	BRI3B_HUMAN	Homo sapiens BRI3 binding protein (BRI3BP), mRNA.	140						integral to membrane|mitochondrial outer membrane				large_intestine(1)|lung(8)|ovary(1)	10	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.35e-05)|Epithelial(86;0.000426)|all cancers(50;0.00576)		GGTTCTTGTCCCTGACCCTGG	0.632000													28	49					1.55811e-20	1.84956e-20	1	1	0
ZNF28	7576	broad.mit.edu	37	19	53303332	53303332	+	Missense_Mutation	SNP	C	C	T	rs142442328	byFrequency	TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr19:53303332C>T	uc002qad.3	-	3	1923	c.1766G>A	c.(1765-1767)cGg>cAg	p.R589Q	ZNF28_uc002qac.3_Missense_Mutation_p.R535Q|ZNF28_uc010eqe.3_Missense_Mutation_p.R535Q|ZNF28_uc021uza.1_Missense_Mutation_p.R536Q	NM_006969	NP_008900	P17035	ZNF28_HUMAN	Homo sapiens zinc finger protein 28 (ZNF28), transcript variant 1, mRNA.	589					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(11)|liver(1)|lung(10)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	34				GBM - Glioblastoma multiforme(134;0.0386)|Lung(386;0.145)		TGAATCCCTCCGGAAAGCCTT	0.443000													7	111					0	0	1	0	0
CSPG4	1464	broad.mit.edu	37	15	75981976	75981976	+	Missense_Mutation	SNP	C	C	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr15:75981976C>T	uc002baw.3	-	2	1523	c.1430G>A	c.(1429-1431)cGc>cAc	p.R477H		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	Homo sapiens chondroitin sulfate proteoglycan 4 (CSPG4), mRNA.	477	Globular or compact configuration stabilized by disulfide bonds.|Neurite growth inhibition (By similarity).			RH -> HY (in Ref. 1; CAA65529).	angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity	p.R477H(2)		breast(1)|cervix(2)|endometrium(5)|kidney(5)|large_intestine(3)|liver(2)|lung(18)|ovary(2)|pancreas(2)|prostate(4)|skin(4)	48						CTCGCCATGGCGTGCCCCTCG	0.637000													6	171					0	0	1	0	0
LAT	27040	broad.mit.edu	37	16	28996234	28996234	+	Missense_Mutation	SNP	G	G	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr16:28996234G>A	uc010vdj.2	+	0	88	c.52G>A	c.(52-54)Gcc>Acc	p.A18T	NPIPL1_uc010vct.2_Intron|SPNS1_uc010vdi.1_3'UTR|SPNS1_uc002drx.2_3'UTR|SPNS1_uc002dsa.2_3'UTR|SPNS1_uc002drz.2_3'UTR|SPNS1_uc010byp.2_3'UTR|LAT_uc002dsb.3_5'UTR|LAT_uc002dsd.3_5'UTR|LAT_uc002dsc.3_5'UTR|LAT_uc010vdk.1_5'Flank|LAT_uc010vdl.1_5'Flank	NM_001014989	NP_001014987	O43561	LAT_HUMAN	Homo sapiens linker for activation of T cells (LAT), transcript variant 4, mRNA.	0					Ras protein signal transduction|T cell receptor signaling pathway|calcium-mediated signaling|integrin-mediated signaling pathway|mast cell degranulation|platelet activation|regulation of T cell activation	immunological synapse|integral to membrane|intracellular|membrane raft	SH3/SH2 adaptor activity			large_intestine(2)|lung(3)|urinary_tract(1)	6		Hepatocellular(780;0.244)				CTTGGGGGGGGCCAGCAGACC	0.731000													20	47					0	0	1	0	0
FRMPD1	22844	broad.mit.edu	37	9	37745145	37745145	+	Missense_Mutation	SNP	G	G	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr9:37745145G>A	uc004aag.1	+	15	3160	c.3116G>A	c.(3115-3117)gGa>gAa	p.G1039E	FRMPD1_uc004aah.1_Missense_Mutation_p.G1039E	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	Homo sapiens FERM and PDZ domain containing 1 (FRMPD1), mRNA.	1039						cytoskeleton|cytosol|plasma membrane				NS(3)|breast(2)|central_nervous_system(2)|endometrium(5)|kidney(4)|large_intestine(22)|lung(34)|ovary(5)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	93				GBM - Glioblastoma multiforme(29;0.00655)		GTCTCTCAAGGAGACACACTA	0.488000													16	27					0	0	1	0	0
FARP1	10160	broad.mit.edu	37	13	99092299	99092299	+	Splice_Site	SNP	T	T	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr13:99092299T>A	uc001vnh.3	+	23	2848	c.2609_splice	c.e23+2	p.S870_splice	FARP1_uc001vnj.3_Splice_Site_p.S839_splice	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	Homo sapiens FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) (FARP1), transcript variant 1, mRNA.	839					regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	Rho guanyl-nucleotide exchange factor activity|cytoskeletal protein binding			breast(3)|endometrium(6)|kidney(6)|large_intestine(13)|lung(16)|ovary(1)|skin(3)|urinary_tract(1)	49	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			GGCCGCCAGGTAACTCGGGAG	0.627000													12	53					0	0	1	0	0
MGC70870	403340	broad.mit.edu	37	GL000205.1	117444	117444	+	RNA	SNP	G	G	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chrGL000205.1:117444G>T	uc002kgk.4	+	0		c.822G>T								Homo sapiens C-terminal binding protein 2 pseudogene (MGC70870), non-coding RNA.																		CCCTCACCAGGGAAGACCTGG	0.557000													6	85					9.16793e-09	1.04325e-08	1	1	0
MUC4	4585	broad.mit.edu	37	3	195505794	195505794	+	Silent	SNP	T	T	G			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr3:195505794T>G	uc021xjp.1	-	1	12813	c.12657A>C	c.(12655-12657)acA>acC	p.T4219T	MUC4_uc003fva.3_5'Flank|MUC4_uc003fvb.3_5'Flank|MUC4_uc003fvc.3_5'Flank|MUC4_uc003fvd.3_5'Flank|MUC4_uc003fve.3_5'Flank|MUC4_uc010hzr.3_5'Flank|MUC4_uc021xjm.1_Intron|MUC4_uc021xjn.1_Intron|MUC4_uc021xjo.1_Intron|MUC4_uc021xjg.1_Intron|MUC4_uc021xjh.1_Intron|MUC4_uc021xji.1_Intron|MUC4_uc021xjj.1_Intron|MUC4_uc021xjk.1_Intron|MUC4_uc021xjl.1_Intron|MUC4_uc003fvo.3_Intron|MUC4_uc003fvp.3_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	Homo sapiens mucin 4, cell surface associated (MUC4), transcript variant 1, mRNA.	976					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TGGCGTGACCTGTGGATGCTG	0.587000													8	289					0	0	1	0	0
NR3C1	2908	broad.mit.edu	37	5	142678363	142678363	+	Missense_Mutation	SNP	G	G	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr5:142678363G>T	uc003lnd.3	-	5	2756	c.1762C>A	c.(1762-1764)Cac>Aac	p.H588N	NR3C1_uc003lmy.3_Missense_Mutation_p.H589N|NR3C1_uc003lmz.3_Missense_Mutation_p.H253N|NR3C1_uc003lna.3_Missense_Mutation_p.H588N|NR3C1_uc003lnb.3_Missense_Mutation_p.H588N|NR3C1_uc011dbk.2_Missense_Mutation_p.H191N|NR3C1_uc003lnf.3_Missense_Mutation_p.H589N|NR3C1_uc003lne.3_Missense_Mutation_p.H588N|NR3C1_uc003lnc.3_Missense_Mutation_p.H588N|NR3C1_uc021yfa.1_Missense_Mutation_p.H588N|NR3C1_uc021yfb.1_Missense_Mutation_p.H588N	NM_001018077	NP_001191193	P04150	GCR_HUMAN	Homo sapiens nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (NR3C1), transcript variant 5, mRNA.	588	Steroid-binding.				chromatin modification|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus|transcription from RNA polymerase II promoter	mitochondrial matrix|nucleoplasm	glucocorticoid receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			breast(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(10)|lung(7)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	35		Acute lymphoblastic leukemia(2;3.2e-05)|all_hematologic(2;0.000361)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)		Amcinonide(DB00288)|Betamethasone(DB00443)|Budesonide(DB01222)|Dexamethasone(DB01234)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluticasone Propionate(DB00588)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Loteprednol Etabonate(DB00873)|Methylprednisolone(DB00959)|Mifepristone(DB00834)|Mometasone(DB00764)|Prednisone(DB00635)	TCATCCAGGTGTAAGTTCCTG	0.423000													3	69					1	1	1	1	0
KIAA1737	85457	broad.mit.edu	37	14	77580238	77580238	+	Silent	SNP	C	C	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr14:77580238C>T	uc001xtd.3	+	3	956	c.777C>T	c.(775-777)ttC>ttT	p.F259F	KIAA1737_uc001xtc.1_Silent_p.F161F	NM_033426	NP_219494	Q9C0C6	K1737_HUMAN	Homo sapiens KIAA1737 (KIAA1737), mRNA.	259										endometrium(2)|lung(4)|prostate(3)	9			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0284)		GTCTGACCTTCGCTTCCCCCG	0.572000													18	21					0	0	1	0	0
ABCC10	89845	broad.mit.edu	37	6	43412898	43412898	+	Missense_Mutation	SNP	A	A	G			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr6:43412898A>G	uc003ouy.1	+	13	3091	c.2876A>G	c.(2875-2877)aAt>aGt	p.N959S	ABCC10_uc003ouz.1_Missense_Mutation_p.N931S|ABCC10_uc010jyo.1_Missense_Mutation_p.N65S	NM_001198934	NP_001185863	Q5T3U5	MRP7_HUMAN	Homo sapiens ATP-binding cassette, sub-family C (CFTR/MRP), member 10 (ABCC10), transcript variant MRP7, mRNA.	959	ABC transmembrane type-1 2.					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			NS(1)|breast(3)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(8)|lung(21)|ovary(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	56	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			GCTGCCCCCAATGGCTCCTCA	0.592000													202	326					0	0	1	0	0
PTPRD	5789	broad.mit.edu	37	9	8504321	8504321	+	Missense_Mutation	SNP	G	G	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr9:8504321G>A	uc003zkk.3	-	22	2505	c.1762C>T	c.(1762-1764)Cgc>Tgc	p.R588C	PTPRD_uc003zkp.3_Missense_Mutation_p.R588C|PTPRD_uc003zkq.3_Missense_Mutation_p.R588C|PTPRD_uc003zkr.3_Missense_Mutation_p.R582C|PTPRD_uc003zks.3_Missense_Mutation_p.R578C|PTPRD_uc022bdj.1_Missense_Mutation_p.R585C	NM_002839	NP_002830	P23468	PTPRD_HUMAN	Homo sapiens protein tyrosine phosphatase, receptor type, D (PTPRD), transcript variant 1, mRNA.	588	Fibronectin type-III 3.				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity	p.R588L(1)		NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TGAGGGGAGCGTGCAGCCAGA	0.458000										TSP Lung(15;0.13)			6	100					0	0	1	0	0
GPR32	2854	broad.mit.edu	37	19	51274070	51274070	+	Silent	SNP	T	T	C			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr19:51274070T>C	uc010ycf.2	+	0	213	c.213T>C	c.(211-213)cgT>cgC	p.R71R		NM_001506	NP_001497	O75388	GPR32_HUMAN	Homo sapiens G protein-coupled receptor 32 (GPR32), mRNA.	71						integral to plasma membrane	N-formyl peptide receptor activity			breast(4)|endometrium(4)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	29		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		CTGTCTTCCGTATGGCACGCA	0.572000													6	129					0	0	1	0	0
HMOX2	3163	broad.mit.edu	37	16	4557977	4557977	+	Silent	SNP	C	C	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr16:4557977C>T	uc002cwr.4	+	4	775	c.468C>T	c.(466-468)cgC>cgT	p.R156R	HMOX2_uc010bts.3_Silent_p.R156R|HMOX2_uc002cwq.4_Silent_p.R156R|HMOX2_uc010btt.3_Silent_p.R156R|HMOX2_uc002cwt.3_Silent_p.R156R	NM_001127204	NP_002125	P30519	HMOX2_HUMAN	Homo sapiens heme oxygenase (decycling) 2 (HMOX2), transcript variant 1, mRNA.	156					cellular iron ion homeostasis|heme catabolic process|heme oxidation|response to hypoxia|transmembrane transport	endoplasmic reticulum membrane|microsome|plasma membrane	electron carrier activity|heme oxygenase (decyclizing) activity|metal ion binding|protein binding			endometrium(1)|large_intestine(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	8					NADH(DB00157)	CATACACCCGCTACATGGGGG	0.617000													72	105					0	0	1	0	0
CLCA1	1179	broad.mit.edu	37	1	86934706	86934706	+	Missense_Mutation	SNP	G	G	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr1:86934706G>A	uc001dlt.3	+	0	312	c.52G>A	c.(52-54)Ggg>Agg	p.G18R	CLCA1_uc001dls.1_Missense_Mutation_p.G18R	NM_001285	NP_001276	A8K7I4	CLCA1_HUMAN	Homo sapiens chloride channel accessory 1 (CLCA1), mRNA.	18					calcium ion transport	extracellular space|integral to plasma membrane	chloride channel activity			NS(1)|breast(3)|endometrium(1)|kidney(3)|large_intestine(9)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	38		Lung NSC(277;0.239)		all cancers(265;0.0249)|Epithelial(280;0.0476)		CCTTCTAGAAGGGGCCCTGAG	0.443000													30	34					0	0	1	0	0
NBPF1	55672	broad.mit.edu	37	1	16891326	16891326	+	Missense_Mutation	SNP	T	T	C			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr1:16891326T>C	uc009vos.1	-	28	3974	c.3086A>G	c.(3085-3087)gAa>gGa	p.E1029G	AB1_uc001ayw.3_5'Flank	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	Homo sapiens neuroblastoma breakpoint family, member 1 (NBPF1), mRNA.	1031	NBPF 6.|Poly-Glu.					cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		GTTTTGAtcttcttccccttc	0.433000													4	8					0	0	1	0	0
DDX11L11	0	broad.mit.edu	37	12	92000	92000	+	Missense_Mutation	SNP	A	A	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr12:92000A>T	uc010sdi.1	-	1	338	c.310T>A	c.(310-312)Ttg>Atg	p.L104M	DDX11L11_uc010sdj.1_Non-coding_Transcript					SubName: Full=DEAD/H box polypeptide 11 like 11;																		GGTCCTGGCAACACTCTGGAC	0.572000													3	11					0	0	1	0	0
IGHE	3497	broad.mit.edu	37	14	106066842	106066842	+	Missense_Mutation	SNP	T	T	C			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr14:106066842T>C	uc001yrw.1	-	3	985	c.973A>G	c.(973-975)Atg>Gtg	p.M325V	abParts_uc021ser.1_Intron|DKFZp686O16217_uc001yrs.3_Intron|DKFZp686O16217_uc001yrt.3_Intron|IGHE_uc001yrx.2_Missense_Mutation_p.M272V|epsilon_IgE_uc010axp.1_5'Flank|IGHE_uc001yru.2_5'Flank					RecName: Full=Ig epsilon chain C region;																		GTGGACCGCATGAGGGCCCTG	0.706000													7	68					0	0	1	0	0
IVL	3713	broad.mit.edu	37	1	152883269	152883269	+	Silent	SNP	A	A	G	rs147245677	by1000genomes	TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr1:152883269A>G	uc021ozl.1	+	0	996	c.996A>G	c.(994-996)caA>caG	p.Q332Q	IVL_uc001fau.3_Silent_p.Q332Q	NM_005547	NP_005538	P07476	INVO_HUMAN	Homo sapiens involucrin (IVL), mRNA.	332	39 X 10 AA approximate tandem repeats of [LP]-[EKG]-[LHVYQEK]-[PLSQE]-[EQDV]- [QHEKRGA]-Q-[EMVQLP]-[GKLE]-[QHVNLD].				isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|keratinization|response to UV-B	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity	p.Q332Q(6)		breast(1)|endometrium(6)|kidney(1)|large_intestine(5)|lung(11)|ovary(3)|skin(1)|upper_aerodigestive_tract(1)	29	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			aggaggggcaactggagcagc	0.662000													8	163					0	0	1	0	0
TTN	7273	broad.mit.edu	37	2	179499952	179499952	+	Missense_Mutation	SNP	G	G	C			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr2:179499952G>C	uc021vsy.1	-	176	34485	c.34260C>G	c.(34258-34260)atC>atG	p.I11420M	MIR548N_uc021vsx.1_Intron|TTN_uc021vsz.1_Missense_Mutation_p.I5115M|TTN_uc021vta.1_Missense_Mutation_p.I5048M|TTN_uc021vtb.1_Missense_Mutation_p.I4923M	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	Homo sapiens titin (TTN), transcript variant N2-A, mRNA.	12347	Glu-rich.|Pro-rich.						ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(24)|autonomic_ganglia(1)|breast(64)|central_nervous_system(14)|cervix(14)|endometrium(96)|haematopoietic_and_lymphoid_tissue(16)|kidney(91)|large_intestine(303)|liver(1)|lung(595)|ovary(58)|pancreas(17)|prostate(38)|skin(60)|stomach(29)|upper_aerodigestive_tract(1)|urinary_tract(26)	1448			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGCCTCTGAGATTTCTGCAT	0.388000													4	114					0	0	1	0	0
PHF3	23469	broad.mit.edu	37	6	64394128	64394128	+	Missense_Mutation	SNP	G	G	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr6:64394128G>A	uc003pep.1	+	2	530	c.505G>A	c.(505-507)Gct>Act	p.A169T	PHF3_uc010kaf.1_Missense_Mutation_p.A169T|PHF3_uc003pem.2_Missense_Mutation_p.A122T|PHF3_uc010kag.1_Missense_Mutation_p.A81T|PHF3_uc010kah.1_5'UTR|PHF3_uc003pen.2_Missense_Mutation_p.A81T|PHF3_uc011dxs.1_Intron|PHF3_uc003peo.3_Missense_Mutation_p.A169T	NM_015153	NP_055968	Q92576	PHF3_HUMAN	Homo sapiens PHD finger protein 3 (PHF3), mRNA.	169					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			breast(7)|cervix(2)|endometrium(8)|kidney(7)|large_intestine(18)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(6)	75	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			TGTATCTACTGCTAAAGCAGG	0.418000													71	108					0	0	1	0	0
ANKRD30BL	554226	broad.mit.edu	37	2	132919192	132919192	+	RNA	SNP	G	G	A	rs111295191		TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr2:132919192G>A	uc002tti.3	-	0		c.334C>T			ANKRD30BL_uc002ttj.3_Intron					Homo sapiens ankyrin repeat domain 30B-like (ANKRD30BL), transcript variant 1, non-coding RNA.											endometrium(1)|kidney(3)	4						CGTAAGAGTCGTTGTTGGTGT	0.602000													9	275					0	0	1	0	0
SH3BGRL	6451	broad.mit.edu	37	X	80532507	80532507	+	Missense_Mutation	SNP	C	C	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chrX:80532507C>A	uc010nmm.3	+	2	630	c.181C>A	c.(181-183)Ctt>Att	p.L61I	SH3BGRL_uc004eef.3_Missense_Mutation_p.L24I|SH3BGRL_uc011mqs.2_Non-coding_Transcript|SH3BGRL_uc010nml.3_Non-coding_Transcript|SH3BGRL_uc010nmn.3_Missense_Mutation_p.L61I			O75368	SH3L1_HUMAN	Homo sapiens SH3 domain binding glutamic acid-rich protein like (SH3BGRL), mRNA.	24						cytoplasm|nucleus	SH3 domain binding|SH3/SH2 adaptor activity			endometrium(1)|lung(2)|ovary(1)	4		all_lung(315;5.94e-05)				ACAAGATGTGCTTGGTTTCCT	0.358000													66	133					1.37693e-34	1.67054e-34	1	1	0
OR7E24	26648	broad.mit.edu	37	19	9362181	9362181	+	Missense_Mutation	SNP	G	G	C			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr19:9362181G>C	uc002mlb.1	+	0	462	c.462G>C	c.(460-462)atG>atC	p.M154I		NM_001079935	NP_001073404	Q6IFN5	O7E24_HUMAN	Homo sapiens olfactory receptor, family 7, subfamily E, member 24 (OR7E24), mRNA.	154					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)	16						GAATCATCATGAACCCACGCC	0.443000													32	66					0	0	1	0	0
PRKACG	5568	broad.mit.edu	37	9	71628295	71628295	+	Silent	SNP	G	G	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr9:71628295G>A	uc004agy.3	-	0	745	c.714C>T	c.(712-714)ccC>ccT	p.P238P		NM_002732	NP_002723	P22612	KAPCG_HUMAN	Homo sapiens protein kinase, cAMP-dependent, catalytic, gamma (PRKACG), mRNA.	238	Protein kinase.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|gluconeogenesis|intracellular protein kinase cascade|male gonad development|nerve growth factor receptor signaling pathway|regulation of insulin secretion|spermatogenesis|transmembrane transport|triglyceride catabolic process|water transport	cytosol|nucleoplasm	ATP binding|cAMP-dependent protein kinase activity			central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						CGGCGTAGAAGGGTGGGAAGC	0.597000													29	52					0	0	1	0	0
PCDHB7	56129	broad.mit.edu	37	5	140553994	140553994	+	Silent	SNP	G	G	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr5:140553994G>T	uc003lit.3	+	0	1752	c.1578G>T	c.(1576-1578)gcG>gcT	p.A526A		NM_018940	NP_061763	Q9Y5E2	PCDB7_HUMAN	Homo sapiens protocadherin beta 7 (PCDHB7), mRNA.	526	Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.A526A(2)|p.A526S(1)|p.Q525Q(1)|p.A526E(1)		NS(2)|breast(2)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(20)|lung(54)|ovary(5)|prostate(7)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	119			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCCTGCAGGCGTTCGAGTTCC	0.706000													5	280					2.48551e-13	2.92935e-13	1	1	0
MUC2	4583	broad.mit.edu	37	11	1078339	1078339	+	Missense_Mutation	SNP	C	C	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr11:1078339C>T	uc001lsx.1	+	4	653	c.626C>T	c.(625-627)cCc>cTc	p.P209L		NM_002457	NP_002448	Q02817	MUC2_HUMAN	Homo sapiens mucin 2, oligomeric mucus/gel-forming (MUC2), mRNA.	209	VWFD 1.					inner mucus layer|outer mucus layer	protein binding			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(5)|lung(22)|ovary(2)|prostate(16)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	102		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	TGTGAGGATCCCGAGGAGGAG	0.642000													51	128					0	0	1	0	0
PTPRO	5800	broad.mit.edu	37	12	15673198	15673198	+	Missense_Mutation	SNP	G	G	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr12:15673198G>A	uc001rcv.2	+	9	2313	c.1843G>A	c.(1843-1845)Gat>Aat	p.D615N	PTPRO_uc001rcw.2_Missense_Mutation_p.D615N	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	Homo sapiens protein tyrosine phosphatase, receptor type, O (PTPRO), transcript variant 1, mRNA.	615						integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(2)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(11)|lung(30)|ovary(2)|prostate(1)|skin(17)|upper_aerodigestive_tract(1)	74		Hepatocellular(102;0.244)				GACGTGGGGAGATCCAGAATT	0.478000													62	137					0	0	1	0	0
OR4X1	390113	broad.mit.edu	37	11	48285602	48285602	+	Missense_Mutation	SNP	T	T	G			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr11:48285602T>G	uc010rht.2	+	0	190	c.190T>G	c.(190-192)Tta>Gta	p.L64V		NM_001004726	NP_001004726	Q8NH49	OR4X1_HUMAN	Homo sapiens olfactory receptor, family 4, subfamily X, member 1 (OR4X1), mRNA.	64					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.Y63C(1)		NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|stomach(1)	28						TCTCAGCTACTTATCCTTTGT	0.493000													17	121					0	0	1	0	0
BRWD3	254065	broad.mit.edu	37	X	80001213	80001213	+	Missense_Mutation	SNP	G	G	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chrX:80001213G>A	uc004edt.3	-	6	709	c.446C>T	c.(445-447)gCc>gTc	p.A149V	BRWD3_uc004edp.3_5'UTR|BRWD3_uc004edq.3_5'UTR|BRWD3_uc010nmj.2_Intron|BRWD3_uc004edr.3_5'UTR|BRWD3_uc004eds.3_5'UTR|BRWD3_uc004edo.3_5'UTR|BRWD3_uc004edu.3_5'UTR|BRWD3_uc004edv.3_5'UTR|BRWD3_uc004edw.3_5'UTR|BRWD3_uc004edx.3_5'UTR|BRWD3_uc004edy.3_5'UTR|BRWD3_uc004edz.3_5'UTR|BRWD3_uc004eea.3_5'UTR|BRWD3_uc004eeb.3_Intron	NM_153252	NP_694984	Q6RI45	BRWD3_HUMAN	Homo sapiens bromodomain and WD repeat domain containing 3 (BRWD3), mRNA.	149										breast(4)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(39)|ovary(4)|prostate(2)|skin(3)	87						TAATTGCCTGGCAGAGGTGAT	0.343000													77	160					0	0	1	0	0
abParts	0	broad.mit.edu	37	14	106691657	106691657	+	Splice_Site	SNP	T	T	C	rs34019594	by1000genomes	TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr14:106691657T>C	uc021ser.1	-	1157		c.25335_splice	c.e1157+1							Parts of antibodies, mostly variable regions.																		TCACACTGACTTCCCCTCACT	0.597000													2	14					0	0	1	0	0
TAF1C	9013	broad.mit.edu	37	16	84214979	84214979	+	Silent	SNP	C	C	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr16:84214979C>A	uc002fhn.3	-	9	1439	c.1197G>T	c.(1195-1197)gtG>gtT	p.V399V	TAF1C_uc010vnz.2_Silent_p.V67V|TAF1C_uc002fho.3_5'UTR|TAF1C_uc010voa.2_Silent_p.V67V|TAF1C_uc002fhm.3_Silent_p.V306V|TAF1C_uc010vnx.2_Silent_p.V373V|TAF1C_uc010vny.2_5'UTR|TAF1C_uc010vob.2_3'UTR	NM_005679	NP_001230088	Q15572	TAF1C_HUMAN	Homo sapiens TATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDa (TAF1C), transcript variant 1, mRNA.	399					regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding			endometrium(1)|kidney(3)|large_intestine(3)|lung(11)|ovary(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	26						CCACGGTCAGCACCCGAGGGT	0.667000													5	114					0.27861	0.280309	1	1	0
NSUN5P2	260294	broad.mit.edu	37	7	72420001	72420001	+	Missense_Mutation	SNP	C	C	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr7:72420001C>T	uc003two.3	-	3	424	c.233G>A	c.(232-234)aGg>aAg	p.R78K	POM121_uc010lam.1_3'UTR|NSUN5P2_uc003twl.3_Non-coding_Transcript|NSUN5P2_uc003twn.3_Missense_Mutation_p.R78K|NSUN5P2_uc003twm.3_Missense_Mutation_p.R78K|NSUN5P2_uc003twp.3_Missense_Mutation_p.R78K|NSUN5P2_uc003twq.3_Missense_Mutation_p.R78K|NSUN5P2_uc010lan.2_Intron					Homo sapiens NOP2/Sun domain family, member 5 pseudogene 2 (NSUN5P2), non-coding RNA.									p.R78K(4)		breast(1)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(3)|ovary(2)|prostate(2)|stomach(1)	15						TGCCAGCCGCCTGGCATCCAG	0.637000													5	176					0	0	1	0	0
TRA2A	29896	broad.mit.edu	37	7	23547073	23547073	+	Missense_Mutation	SNP	G	G	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr7:23547073G>A	uc003swi.3	-	4	820	c.607C>T	c.(607-609)Cca>Tca	p.P203S	TRA2A_uc011jzb.2_Non-coding_Transcript|TRA2A_uc011jzc.2_Missense_Mutation_p.P102S|TRA2A_uc011jzd.2_Missense_Mutation_p.P102S	NM_013293	NP_037425	Q13595	TRA2A_HUMAN	Homo sapiens transformer 2 alpha homolog (Drosophila) (TRA2A), mRNA.	203	Linker.				nuclear mRNA splicing, via spliceosome	nucleus	RNA binding|nucleotide binding			endometrium(1)|large_intestine(1)|lung(6)|ovary(1)|prostate(1)	10						CCTGGTGTTGGTGTGTGCGCT	0.413000													24	44					0	0	1	0	0
ADAM18	8749	broad.mit.edu	37	8	39550201	39550201	+	Splice_Site	SNP	T	T	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr8:39550201T>A	uc003xni.3	+	17	1957	c.1902_splice	c.e17+2	p.G634_splice	ADAM18_uc010lww.3_Splice_Site|ADAM18_uc010lwx.3_Splice_Site_p.G610_splice	NM_014237	NP_055052	Q9Y3Q7	ADA18_HUMAN	Homo sapiens ADAM metallopeptidase domain 18 (ADAM18), transcript variant 1, mRNA.	634	EGF-like.				cell differentiation|multicellular organismal development|proteolysis|spermatogenesis	integral to membrane|membrane fraction	metalloendopeptidase activity|zinc ion binding			NS(2)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(31)|ovary(1)|prostate(1)|skin(12)|stomach(1)|upper_aerodigestive_tract(3)	71		all_cancers(7;1.32e-05)|all_epithelial(6;3.08e-10)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00769)|Breast(189;0.0112)	LUSC - Lung squamous cell carcinoma(45;0.000199)			GGGAAAGGGGTAAGTCACTTT	0.348000													44	79					0	0	1	0	0
FAM105A	54491	broad.mit.edu	37	5	14601482	14601482	+	Silent	SNP	G	G	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr5:14601482G>A	uc003jfj.3	+	3	392	c.279G>A	c.(277-279)gaG>gaA	p.E93E		NM_019018	NP_061891	Q9NUU6	F105A_HUMAN	Homo sapiens family with sequence similarity 105, member A (FAM105A), mRNA.	93										large_intestine(3)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11	Lung NSC(4;0.00592)					TGGAGGCAGAGGTTGATTTAC	0.423000													35	121					0	0	1	0	0
FAM185A	222234	broad.mit.edu	37	7	102389716	102389716	+	Missense_Mutation	SNP	G	G	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr7:102389716G>T	uc011klf.2	+	0	318	c.62G>T	c.(61-63)cGa>cTa	p.R21L	RASA4_uc011kld.1_5'Flank|FAM185A_uc022ajn.1_Non-coding_Transcript|FAM185A_uc011klg.2_Missense_Mutation_p.R21L|FAM185A_uc022ajo.1_Non-coding_Transcript	NM_001145268	NP_001138740	Q8N0U4	F185A_HUMAN	Homo sapiens family with sequence similarity 185, member A (FAM185A), transcript variant 1, mRNA.	21										kidney(1)	1						CGTCAGGTCCGACTGTGGGCT	0.667000													4	212					0.014758	0.01551	1	1	0
FAM86DP	692099	broad.mit.edu	37	3	75476735	75476735	+	Silent	SNP	C	C	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr3:75476735C>T	uc003dpp.4	-	5	689	c.330G>A	c.(328-330)gaG>gaA	p.E110E	FAM86DP_uc003dps.4_Intron|FAM86DP_uc003dpq.4_Silent_p.E18E|FAM86DP_uc003dpr.4_Intron					Homo sapiens family with sequence similarity 86, member D, pseudogene (FAM86DP), non-coding RNA.									p.E194E(3)									CTCGGAGCTGCTCGAGGACCC	0.602000													4	38					0	0	1	0	0
ZNF516	9658	broad.mit.edu	37	18	74154244	74154244	+	Missense_Mutation	SNP	G	G	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr18:74154244G>T	uc021ulp.1	-	2	1085	c.767C>A	c.(766-768)gCc>gAc	p.A256D		NM_014643	NP_055458	Q92618	ZN516_HUMAN	Homo sapiens zinc finger protein 516 (ZNF516), mRNA.	256					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.A256D(4)		central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(7)|lung(11)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32		Prostate(75;0.0869)|Esophageal squamous(42;0.129)		OV - Ovarian serous cystadenocarcinoma(15;7.64e-06)|BRCA - Breast invasive adenocarcinoma(31;0.238)		CTGGCTGAAGGCCTGGCCACA	0.687000													3	81					0.0215528	0.0223661	1	1	0
RAD9B	144715	broad.mit.edu	37	12	110969392	110969392	+	Silent	SNP	A	A	G			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr12:110969392A>G	uc001trf.4	+	11	1386	c.1248A>G	c.(1246-1248)aaA>aaG	p.K416K	RAD9B_uc001trg.4_3'UTR|RAD9B_uc010sya.2_Missense_Mutation_p.K311R|RAD9B_uc001tre.4_3'UTR|RAD9B_uc001trd.4_3'UTR	NM_152442	NP_689655	Q6WBX8	RAD9B_HUMAN	Homo sapiens RAD9 homolog B (S. pombe) (RAD9B), mRNA.	413					DNA repair|DNA replication|cell cycle checkpoint	nucleoplasm	protein binding			endometrium(1)|large_intestine(2)|lung(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	7						GCTGCAGGAAAGAATTTAATG	0.353000													8	13					0	0	1	0	0
FLJ36000	284124	broad.mit.edu	37	17	21904083	21904083	+	RNA	SNP	C	C	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr17:21904083C>A	uc002gza.2	+	0		c.22C>A								Homo sapiens uncharacterized FLJ36000 (FLJ36000), non-coding RNA.																		ctgacctctccacggggtcca	0.677000													3	48					0.115264	0.118128	1	1	0
ZNF451	26036	broad.mit.edu	37	6	56989656	56989656	+	Splice_Site	SNP	G	G	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr6:56989656G>A	uc003pdm.1	+	4	536	c.312_splice	c.e4+1	p.R104_splice	ZNF451_uc003pdl.3_Splice_Site_p.R104_splice|ZNF451_uc003pdn.1_Splice_Site_p.R104_splice|BC032020_uc003pdq.1_Intron|ZNF451_uc003pdk.1_Splice_Site_p.R104_splice	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	Homo sapiens zinc finger protein 451 (ZNF451), transcript variant 1, mRNA.	104					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			AGAGCATTCAGAGTATGTGCT	0.289000													13	188					0	0	1	0	0
CD2AP	23607	broad.mit.edu	37	6	47471115	47471115	+	Missense_Mutation	SNP	A	A	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr6:47471115A>T	uc003oyw.3	+	1	560	c.104A>T	c.(103-105)gAa>gTa	p.E35V		NM_012120	NP_036252	Q9Y5K6	CD2AP_HUMAN	Homo sapiens CD2-associated protein (CD2AP), mRNA.	35	Interaction with ANLN and localization to the midbody.|SH3 1; truncated.				cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			kidney(1)|large_intestine(9)|lung(5)|ovary(1)|prostate(1)|skin(2)|urinary_tract(1)	20			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			CTACAGGAGGAAGGGTGGCTG	0.378000													19	260					0	0	1	0	0
SVEP1	79987	broad.mit.edu	37	9	113233740	113233740	+	Missense_Mutation	SNP	C	C	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr9:113233740C>A	uc010mtz.3	-	15	3239	c.2902G>T	c.(2902-2904)Gca>Tca	p.A968S	SVEP1_uc010mua.1_Missense_Mutation_p.A968S	NM_153366	NP_699197	Q4LDE5	SVEP1_HUMAN	Homo sapiens sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 (SVEP1), mRNA.	968					cell adhesion	cytoplasm|extracellular region|membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(2)|endometrium(19)|kidney(8)|large_intestine(24)|lung(58)|ovary(7)|prostate(7)|skin(1)|stomach(4)|upper_aerodigestive_tract(5)|urinary_tract(4)	147						ATTTCTGATGCAAGCTGAAAG	0.428000													13	105					1.3612e-06	1.50737e-06	1	1	0
ANKRD30BL	554226	broad.mit.edu	37	2	132919099	132919099	+	RNA	SNP	C	C	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr2:132919099C>T	uc002tti.3	-	0		c.427G>A			ANKRD30BL_uc002ttj.3_Intron					Homo sapiens ankyrin repeat domain 30B-like (ANKRD30BL), transcript variant 1, non-coding RNA.											endometrium(1)|kidney(3)	4						CCATTGTCGTCTTCTTCATCA	0.582000													8	129					0	0	1	0	0
RHEB	6009	broad.mit.edu	37	7	151188050	151188050	+	Missense_Mutation	SNP	A	A	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr7:151188050A>T	uc003wkh.1	-	1	516	c.103T>A	c.(103-105)Tac>Aac	p.Y35N		NM_005614	NP_005605	Q15382	RHEB_HUMAN	Homo sapiens Ras homolog enriched in brain (RHEB), mRNA.	35					cell cycle arrest|insulin receptor signaling pathway|positive regulation of TOR signaling cascade|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding|GTPase activity|metal ion binding|protein binding	p.Y35N(2)		breast(3)|endometrium(1)|kidney(2)|large_intestine(1)|lung(7)	14			OV - Ovarian serous cystadenocarcinoma(82;0.00306)	UCEC - Uterine corpus endometrioid carcinoma (81;0.174)		GTTGGATCGTAGGAGTCCACA	0.358000													4	63					0	0	1	0	0
PPP2R3A	5523	broad.mit.edu	37	3	135825108	135825108	+	Silent	SNP	T	T	C			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr3:135825108T>C	uc003eqv.2	+	12	3890	c.3273T>C	c.(3271-3273)gcT>gcC	p.A1091A	PPP2R3A_uc011blz.2_Silent_p.A355A|PPP2R3A_uc003eqw.2_Silent_p.A470A	NM_002718	NP_002709	Q06190	P2R3A_HUMAN	Homo sapiens protein phosphatase 2, regulatory subunit B'', alpha (PPP2R3A), transcript variant 1, mRNA.	1091					protein dephosphorylation	protein phosphatase type 2A complex	calcium ion binding|protein binding|protein phosphatase type 2A regulator activity			breast(2)|cervix(1)|endometrium(2)|large_intestine(7)|lung(10)|ovary(3)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						GGTTTGCCGCTGAGGAGTATG	0.453000													26	56					0	0	1	0	0
YEATS2	55689	broad.mit.edu	37	3	183525842	183525842	+	Missense_Mutation	SNP	G	G	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr3:183525842G>T	uc003fly.2	+	28	4231	c.4036G>T	c.(4036-4038)Gca>Tca	p.A1346S	AX746590_uc003fma.1_5'Flank|YEATS2_uc021xie.1_5'Flank	NM_018023	NP_060493	Q9ULM3	YETS2_HUMAN	Homo sapiens YEATS domain containing 2 (YEATS2), mRNA.	1346					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(24)|ovary(3)|prostate(2)|skin(3)	49	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			GCAGCCCGTGGCACTCCACAG	0.572000													5	109					0.0215528	0.0223661	1	1	0
DBN1	1627	broad.mit.edu	37	5	176885609	176885609	+	Missense_Mutation	SNP	G	G	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr5:176885609G>A	uc003mgx.2	-	12	1514	c.1232C>T	c.(1231-1233)gCg>gTg	p.A411V	DBN1_uc011dga.1_Missense_Mutation_p.A141V|DBN1_uc003mgy.2_Missense_Mutation_p.A409V|DBN1_uc010jkn.1_Missense_Mutation_p.A359V|DBN1_uc003mgz.1_Missense_Mutation_p.A392V	NM_080881	NP_543157	Q16643	DREB_HUMAN	Homo sapiens drebrin 1 (DBN1), transcript variant 2, mRNA.	409					actin filament organization|regulation of dendrite development|regulation of neuronal synaptic plasticity	actomyosin|cytoplasm|dendrite	actin binding|profilin binding			breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(1)|lung(12)|ovary(1)|skin(2)	25	all_cancers(89;2.17e-05)|Renal(175;0.000269)|Lung NSC(126;0.0014)|all_lung(126;0.0025)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCGGGGAGGCGCCTGTGCCTG	0.687000													4	117					0	0	1	0	0
NFASC	23114	broad.mit.edu	37	1	204985554	204985554	+	Nonsense_Mutation	SNP	G	G	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr1:204985554G>T	uc010prc.2	+	26	3639	c.2110G>T	c.(2110-2112)Gaa>Taa	p.E704*	NFASC_uc001hbj.3_Nonsense_Mutation_p.E1204*|NFASC_uc010pra.2_Nonsense_Mutation_p.E1138*|NFASC_uc001hbi.3_Nonsense_Mutation_p.E1133*|NFASC_uc010prb.2_Nonsense_Mutation_p.E1153*|NFASC_uc001hbl.2_Nonsense_Mutation_p.E280*|NFASC_uc001hbm.2_Nonsense_Mutation_p.E227*|NFASC_uc009xbh.2_Missense_Mutation_p.M58I|NFASC_uc001hbo.2_Missense_Mutation_p.M79I			O94856	NFASC_HUMAN	Homo sapiens neurofascin (NFASC), transcript variant 2, mRNA.	1311	Fibronectin type-III 1.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding	p.E703D(1)		NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(22)|liver(1)|lung(24)|ovary(3)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	81	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			TCAGTTCAATGAAGACGGCTC	0.562000													28	233					7.35883e-32	8.86283e-32	1	1	0
NIPSNAP3B	55335	broad.mit.edu	37	9	107521616	107521616	+	Missense_Mutation	SNP	A	A	C			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr9:107521616A>C	uc004bch.1	+	5	846	c.741A>C	c.(739-741)aaA>aaC	p.K247N	NIPSNAP3B_uc011lvt.2_3'UTR|NIPSNAP3B_uc011lvu.1_Intron	NM_015469	NP_056284	Q9BS92	NPS3B_HUMAN	Homo sapiens nipsnap homolog 3A (C. elegans) (NIPSNAP3A), mRNA.	247										breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|pancreas(1)|prostate(1)|skin(1)|stomach(2)	11						CACCACTGAAATAGTTTTCTA	0.358000													19	46					0	0	1	0	0
SDCCAG3	10807	broad.mit.edu	37	9	139302279	139302279	+	Splice_Site	SNP	T	T	G			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr9:139302279T>G	uc004chi.3	-	4	607	c.402_splice	c.e4+1	p.K134_splice	SDCCAG3_uc004chj.3_Splice_Site_p.K111_splice|SDCCAG3_uc004chk.3_Splice_Site_p.K61_splice|PMPCA_uc011mdy.1_5'Flank|PMPCA_uc010nbk.2_5'Flank|PMPCA_uc011mdz.2_5'Flank|PMPCA_uc004chl.3_5'Flank|PMPCA_uc010nbl.3_5'Flank	NM_001039707	NP_001034796	Q96C92	SDCG3_HUMAN	Homo sapiens serologically defined colon cancer antigen 3 (SDCCAG3), transcript variant 1, mRNA.	134						cytoplasm				NS(1)|breast(2)|cervix(1)|endometrium(2)|large_intestine(1)|lung(9)	16		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;8.18e-06)|Epithelial(140;9.31e-06)		TGGATTTACCTTTGCATAAAT	0.522000													10	22					0	0	1	0	0
OR10C1	442194	broad.mit.edu	37	6	29408232	29408232	+	Missense_Mutation	SNP	C	C	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr6:29408232C>T	uc011dlp.2	+	0	517	c.440C>T	c.(439-441)gCg>gTg	p.A147V	OR11A1_uc010jrh.1_Intron	NM_013941	NP_039229	Q96KK4	O10C1_HUMAN	Homo sapiens olfactory receptor, family 10, subfamily C, member 1 (OR10C1), mRNA.	147					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S146L(1)		NS(1)|breast(2)|kidney(1)|large_intestine(3)|liver(2)|lung(14)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						GCTGGGTCGGCGTGGGCCTGT	0.622000													3	42					0	0	1	0	0
PLEKHG4B	153478	broad.mit.edu	37	5	169688	169688	+	Missense_Mutation	SNP	G	G	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr5:169688G>T	uc003jak.2	+	11	2692	c.2642G>T	c.(2641-2643)gGc>gTc	p.G881V		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	Homo sapiens pleckstrin homology domain containing, family G (with RhoGef domain) member 4B (PLEKHG4B), mRNA.	881	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			endometrium(1)|large_intestine(2)|lung(2)|prostate(3)|skin(3)	11			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		TTGGCCGTGGGCCGCAGTTTC	0.647000													4	54					0.00024832	0.000271343	1	1	0
ARHGEF40	55701	broad.mit.edu	37	14	21543565	21543565	+	Missense_Mutation	SNP	G	G	C			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr14:21543565G>C	uc001vzp.3	+	3	1554	c.1525G>C	c.(1525-1527)Gac>Cac	p.D509H	ARHGEF40_uc001vzn.1_Missense_Mutation_p.D509H|ARHGEF40_uc001vzo.1_Intron|ARHGEF40_uc010aij.3_Non-coding_Transcript|ARHGEF40_uc010tln.2_5'UTR	NM_018071	NP_060541	Q8TER5	ARH40_HUMAN	Homo sapiens Rho guanine nucleotide exchange factor (GEF) 40 (ARHGEF40), mRNA.	509					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(4)|ovary(3)|upper_aerodigestive_tract(2)	9						AGGAAAAGGGGACAACATTCC	0.557000													49	133					0	0	1	0	0
HDAC5	10014	broad.mit.edu	37	17	42171119	42171119	+	Missense_Mutation	SNP	G	G	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr17:42171119G>A	uc002iff.1	-	3	513	c.181C>T	c.(181-183)Cgg>Tgg	p.R61W	HDAC5_uc002ifd.1_Missense_Mutation_p.R60W|HDAC5_uc002ife.1_Missense_Mutation_p.R60W|HDAC5_uc010czp.1_Missense_Mutation_p.R60W|HDAC5_uc002ifh.2_Missense_Mutation_p.R60W	NM_001015053	NP_001015053	Q9UQL6	HDAC5_HUMAN	Homo sapiens histone deacetylase 5 (HDAC5), transcript variant 3, mRNA.	60					B cell differentiation|cellular response to insulin stimulus|chromatin remodeling|chromatin silencing|inflammatory response|negative regulation of cell migration involved in sprouting angiogenesis|negative regulation of myotube differentiation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of protein binding|transcription, DNA-dependent	cytoplasm|histone deacetylase complex	NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|histone deacetylase activity (H3-K16 specific)|protein kinase C binding|repressing transcription factor binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(7)|ovary(1)|prostate(2)|skin(1)	21		Breast(137;0.00637)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.118)		AGAGCCCCCCGTAGCTCCACA	0.667000													65	71					0	0	1	0	0
HDC	3067	broad.mit.edu	37	15	50535435	50535435	+	Missense_Mutation	SNP	C	C	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr15:50535435C>T	uc001zxz.3	-	10	1489	c.1147G>A	c.(1147-1149)Gaa>Aaa	p.E383K	HDC_uc001zxy.3_Missense_Mutation_p.E126K|HDC_uc010uff.2_Missense_Mutation_p.E350K	NM_002112	NP_002103	P19113	DCHS_HUMAN	Homo sapiens histidine decarboxylase (HDC), mRNA.	383					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(13)|lung(25)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	50		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	TTAGCCATTTCAGTACCCTGG	0.403000													51	76					0	0	1	0	0
CUL2	8453	broad.mit.edu	37	10	35360197	35360197	+	Missense_Mutation	SNP	G	G	C			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr10:35360197G>C	uc010qer.2	-	1	210	c.106C>G	c.(106-108)Ctt>Gtt	p.L36V	CUL2_uc021ppa.1_Missense_Mutation_p.L30V|CUL2_uc009xma.3_5'UTR|CUL2_uc001ixv.3_Missense_Mutation_p.L17V|CUL2_uc001ixw.3_Missense_Mutation_p.L17V|CUL2_uc010qes.2_Missense_Mutation_p.L17V	NM_001198778	NP_001185707	Q13617	CUL2_HUMAN	Homo sapiens cullin 2 (CUL2), transcript variant 1, mRNA.	17					G1/S transition of mitotic cell cycle|cell cycle arrest|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex	ubiquitin protein ligase binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(11)|ovary(3)|prostate(2)|skin(1)|urinary_tract(2)	31						GTCGTCAAAAGTTTGTTCCAT	0.358000													30	99					0	0	1	0	0
NRXN1	9378	broad.mit.edu	37	2	50850682	50850682	+	Missense_Mutation	SNP	G	G	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr2:50850682G>T	uc021vhh.1	-	4	1825	c.904C>A	c.(904-906)Caa>Aaa	p.Q302K	NRXN1_uc002rxb.4_5'UTR|NRXN1_uc021vhg.1_Missense_Mutation_p.Q335K|NRXN1_uc021vhi.1_Missense_Mutation_p.Q331K|NRXN1_uc021vhj.1_Missense_Mutation_p.Q298K|NRXN1_uc002rxc.1_Non-coding_Transcript	NM_004801	NP_004792	Q9ULB1	NRX1A_HUMAN	Homo sapiens neurexin 1 (NRXN1), transcript variant alpha1, mRNA.	302	Laminin G-like 2.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity	p.G301E(1)		breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CTGCTGCTTTGAATGGGGTTT	0.393000													23	34					2.81731e-10	3.27364e-10	1	1	0
MAST3	23031	broad.mit.edu	37	19	18254627	18254627	+	Silent	SNP	C	C	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr19:18254627C>T	uc002nhz.4	+	20	2307	c.2307C>T	c.(2305-2307)ccC>ccT	p.P769P		NM_015016	NP_055831	O60307	MAST3_HUMAN	Homo sapiens microtubule associated serine/threonine kinase 3 (MAST3), mRNA.	769							ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(8)|lung(6)|ovary(4)|pancreas(1)|stomach(1)	31						CGTCCCAGCCCGAGCGGGGTC	0.617000													4	58					0	0	1	0	0
MED27	9442	broad.mit.edu	37	9	134735980	134735980	+	Missense_Mutation	SNP	G	G	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr9:134735980G>A	uc004cbe.2	-	7	924	c.881C>T	c.(880-882)cCg>cTg	p.P294L	MED27_uc004cbf.2_Missense_Mutation_p.P258L	NM_004269	NP_004260	Q6P2C8	MED27_HUMAN	Homo sapiens mediator complex subunit 27 (MED27), transcript variant 1, mRNA.	294					regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleolus|transcription factor complex	protein binding|transcription coactivator activity	p.P294L(8)|p.P294fs*>18(2)		breast(1)|endometrium(4)|kidney(3)|large_intestine(3)|lung(5)|skin(1)|urinary_tract(1)	18		Myeloproliferative disorder(178;0.206)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000193)		CCTCCATGTCGGGGGAAGGCC	0.597000													3	100					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33345744	33345744	+	Silent	SNP	C	C	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr20:33345744C>T	uc002xav.3	-	7	3378	c.807G>A	c.(805-807)caG>caA	p.Q269Q	NCOA6_uc002xaw.3_Silent_p.Q269Q|NCOA6_uc021wcd.1_Silent_p.Q269Q|NCOA6_uc021wce.1_Silent_p.Q269Q|NCOA6_uc021wcf.1_Silent_p.Q269Q|NCOA6_uc010gew.1_Silent_p.Q226Q	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	Homo sapiens nuclear receptor coactivator 6 (NCOA6), transcript variant 1, mRNA.	269	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				DNA recombination|DNA repair|DNA replication|brain development|cellular lipid metabolic process|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.Q269Q(29)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gctgctgctgctgttgttgtt	0.537000													3	89					0	0	1	0	0
CASC5	57082	broad.mit.edu	37	15	40915310	40915310	+	Missense_Mutation	SNP	G	G	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr15:40915310G>T	uc010bbs.1	+	10	3087	c.2926G>T	c.(2926-2928)Gtt>Ttt	p.V976F	CASC5_uc010ucq.1_Missense_Mutation_p.V800F|CASC5_uc001zme.3_Missense_Mutation_p.V950F|CASC5_uc010bbt.1_Missense_Mutation_p.V950F	NM_170589	NP_733468	Q8NG31	CASC5_HUMAN	Homo sapiens cancer susceptibility candidate 5 (CASC5), transcript variant 1, mRNA.	976	2 X 104 AA approximate repeats.				CenH3-containing nucleosome assembly at centromere|acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			NS(1)|breast(7)|central_nervous_system(1)|endometrium(6)|kidney(4)|large_intestine(13)|lung(16)|skin(3)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	57		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		AGATAATCATGTTGAACTAGA	0.378000													19	65					8.34094e-07	9.29902e-07	1	1	0
SPOPL	339745	broad.mit.edu	37	2	139322375	139322375	+	Missense_Mutation	SNP	A	A	G			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr2:139322375A>G	uc002tvh.3	+	8	1335	c.935A>G	c.(934-936)cAc>cGc	p.H312R		NM_001001664	NP_001001664	Q6IQ16	SPOPL_HUMAN	Homo sapiens speckle-type POZ protein-like (SPOPL), mRNA.	312						nucleus				breast(2)|cervix(2)|endometrium(2)|large_intestine(2)|lung(11)|skin(2)	21				BRCA - Breast invasive adenocarcinoma(221;0.0296)		GCAGATTTGCACAGTGCAGAA	0.413000													21	114					0	0	1	0	0
IBTK	25998	broad.mit.edu	37	6	82883139	82883139	+	Missense_Mutation	SNP	T	T	C			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr6:82883139T>C	uc003pjl.1	-	26	4269	c.3742A>G	c.(3742-3744)Acc>Gcc	p.T1248A	IBTK_uc011dyu.1_Missense_Mutation_p.T199A|IBTK_uc011dyv.1_Missense_Mutation_p.T1233A|IBTK_uc011dyw.1_Missense_Mutation_p.T1047A|IBTK_uc010kbi.1_Missense_Mutation_p.T942A	NM_015525	NP_056340	Q9P2D0	IBTK_HUMAN	Homo sapiens inhibitor of Bruton agammaglobulinemia tyrosine kinase (IBTK), mRNA.	1248					negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity	p.T1248T(1)		central_nervous_system(2)|endometrium(9)|kidney(3)|large_intestine(10)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	54		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)		GGTCCTGGGGTACCATGGGTA	0.373000													3	38					0	0	1	0	0
DHX38	9785	broad.mit.edu	37	16	72141342	72141342	+	Missense_Mutation	SNP	G	G	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr16:72141342G>A	uc002fcb.3	+	19	3059	c.2704G>A	c.(2704-2706)Ggg>Agg	p.G902R	DHX38_uc010vmp.2_Missense_Mutation_p.G214R	NM_014003	NP_054722	Q92620	PRP16_HUMAN	Homo sapiens DEAH (Asp-Glu-Ala-His) box polypeptide 38 (DHX38), mRNA.	902	Helicase C-terminal.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			endometrium(5)|kidney(1)|large_intestine(16)|lung(15)|pancreas(1)|prostate(2)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	48		Ovarian(137;0.125)				CAAGTCCCTCGGGGTGCAGGA	0.597000													4	92					0	0	1	0	0
GPR32	2854	broad.mit.edu	37	19	51274076	51274076	+	Silent	SNP	A	A	C			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr19:51274076A>C	uc010ycf.2	+	0	219	c.219A>C	c.(217-219)gcA>gcC	p.A73A		NM_001506	NP_001497	O75388	GPR32_HUMAN	Homo sapiens G protein-coupled receptor 32 (GPR32), mRNA.	73						integral to plasma membrane	N-formyl peptide receptor activity			breast(4)|endometrium(4)|kidney(1)|large_intestine(3)|lung(12)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	29		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		TCCGTATGGCACGCACGGTCT	0.572000													7	129					0	0	1	0	0
SCNN1A	6337	broad.mit.edu	37	12	6457064	6457064	+	Missense_Mutation	SNP	G	G	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr12:6457064G>A	uc001qnw.3	-	11	2426	c.2162C>T	c.(2161-2163)tCc>tTc	p.S721F	SCNN1A_uc001qnv.3_Missense_Mutation_p.S362F|SCNN1A_uc001qnx.3_Missense_Mutation_p.S662F|SCNN1A_uc010sfb.2_Missense_Mutation_p.S685F	NM_001159576	NP_001029	P37088	SCNNA_HUMAN	Homo sapiens sodium channel, nonvoltage-gated 1 alpha (SCNN1A), transcript variant 2, mRNA.	662					excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(2)|lung(6)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	27					Amiloride(DB00594)|Triamterene(DB00384)	AGGACAGGTGGAGGAACTGGC	0.672000													22	50					0	0	1	0	0
FAM86DP	692099	broad.mit.edu	37	3	75476737	75476737	+	Missense_Mutation	SNP	C	C	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr3:75476737C>T	uc003dpp.4	-	5	687	c.328G>A	c.(328-330)Gag>Aag	p.E110K	FAM86DP_uc003dps.4_Intron|FAM86DP_uc003dpq.4_Missense_Mutation_p.E18K|FAM86DP_uc003dpr.4_Intron					Homo sapiens family with sequence similarity 86, member D, pseudogene (FAM86DP), non-coding RNA.									p.E194K(2)									CGGAGCTGCTCGAGGACCCGG	0.602000													4	38					0	0	1	0	0
SGK223	157285	broad.mit.edu	37	8	8239069	8239069	+	Missense_Mutation	SNP	C	C	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr8:8239069C>A	uc003wsh.4	-	0	189	c.189G>T	c.(187-189)agG>agT	p.R63S		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	Homo sapiens homolog of rat pragma of Rnd2 (SGK223), mRNA.	63							ATP binding|non-membrane spanning protein tyrosine kinase activity										AGTTCTCAGGCCTGGGAGGCA	0.657000													7	101					5.18039e-06	5.69843e-06	1	1	0
TUBG1	7283	broad.mit.edu	37	17	40765685	40765685	+	Silent	SNP	C	C	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr17:40765685C>T	uc002ian.3	+	6	1025	c.627C>T	c.(625-627)gcC>gcT	p.A209A		NM_001070	NP_001061	P23258	TBG1_HUMAN	Homo sapiens tubulin, gamma 1 (TUBG1), mRNA.	209					G2/M transition of mitotic cell cycle|meiotic spindle organization|protein polymerization	condensed nuclear chromosome|cytosol|gamma-tubulin complex|polar microtubule	GTP binding|GTPase activity|protein binding|structural constituent of cytoskeleton	p.A209A(2)		endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	12		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.129)		ACAACACAGCCCTGAACCGGA	0.562000													6	150					0	0	1	0	0
UNC93A	54346	broad.mit.edu	37	6	167709627	167709627	+	Missense_Mutation	SNP	C	C	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr6:167709627C>T	uc003qvq.3	+	2	552	c.377C>T	c.(376-378)gCg>gTg	p.A126V	UNC93A_uc003qvr.3_Missense_Mutation_p.A126V	NM_018974	NP_061847	Q86WB7	UN93A_HUMAN	Homo sapiens unc-93 homolog A (C. elegans) (UNC93A), transcript variant 1, mRNA.	126						integral to membrane|plasma membrane		p.A126A(1)		breast(2)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(7)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	40		Breast(66;7.62e-05)|Ovarian(120;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		GCAGAGAAGGCGGGAAAGCGT	0.547000													88	131					0	0	1	0	0
KRTAP10-7	386675	broad.mit.edu	37	21	46020576	46020576	+	Missense_Mutation	SNP	G	G	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr21:46020576G>A	uc002zfn.4	+	0	80	c.55G>A	c.(55-57)Gtc>Atc	p.V19I	TSPEAR_uc002zfe.1_Intron|TSPEAR_uc010gpv.1_Intron	NM_198689	NP_941962	P60409	KR107_HUMAN	Homo sapiens keratin associated protein 10-7 (KRTAP10-7), mRNA.	19						keratin filament				breast(1)|large_intestine(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	8						CGGCAGCCGCGTCTGCCTTCC	0.642000													5	147					0	0	1	0	0
GRTP1	79774	broad.mit.edu	37	13	113979922	113979922	+	Silent	SNP	C	C	G			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr13:113979922C>G	uc010tkc.2	-	6	1072	c.975G>C	c.(973-975)ctG>ctC	p.L325L	GRTP1_uc001vtn.3_Intron|GRTP1_uc010tkb.2_3'UTR	NM_024719	NP_078995	Q5TC63	GRTP1_HUMAN	Homo sapiens growth hormone regulated TBC protein 1 (GRTP1), mRNA.	0						intracellular	Rab GTPase activator activity			cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|lung(4)|ovary(1)|prostate(1)	14	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0314)|all_epithelial(44;0.011)|all_lung(25;0.0271)|Lung NSC(25;0.0978)|Breast(118;0.188)	all cancers(43;0.025)|GBM - Glioblastoma multiforme(44;0.206)|Epithelial(84;0.246)			CCCCGGGCTGCAGGTGAGGCG	0.647000													23	31					0	0	1	0	0
GPR126	57211	broad.mit.edu	37	6	142741042	142741042	+	Silent	SNP	C	C	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr6:142741042C>T	uc010khe.3	+	21	3531	c.3120C>T	c.(3118-3120)ttC>ttT	p.F1040F	GPR126_uc010khc.3_Silent_p.F1040F|GPR126_uc010khd.3_Silent_p.F1012F|GPR126_uc010khf.3_Silent_p.F1012F|GPR126_uc011edv.2_Silent_p.F100F	NM_198569	NP_940971	Q86SQ4	GP126_HUMAN	Homo sapiens G protein-coupled receptor 126 (GPR126), transcript variant b1, mRNA.	1040					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity	p.R1039H(1)|p.R1039C(1)		cervix(1)|endometrium(1)|kidney(3)|large_intestine(12)|lung(10)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	36	Breast(32;0.176)			OV - Ovarian serous cystadenocarcinoma(155;9.33e-06)|GBM - Glioblastoma multiforme(68;0.00121)		TTGCCATGTTCATTGTGGTAA	0.428000													3	149					0	0	1	0	0
IFITM3	10410	broad.mit.edu	37	11	320606	320606	+	Missense_Mutation	SNP	G	G	T	rs149004156	by1000genomes	TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr11:320606G>T	uc001lpa.2	-	0	309	c.208C>A	c.(208-210)Ccc>Acc	p.P70T	BC040735_uc001loz.3_Intron	NM_021034	NP_066362	Q01628	IFM3_HUMAN	Homo sapiens interferon induced transmembrane protein 3 (IFITM3), mRNA.	70	Interaction with SPP1.				response to virus|type I interferon-mediated signaling pathway	integral to membrane|plasma membrane		p.P70T(6)		central_nervous_system(7)|endometrium(7)|kidney(2)|large_intestine(1)|lung(1)	18		all_cancers(49;2e-09)|all_epithelial(84;3.36e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;8.85e-28)|Epithelial(43;5.52e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0327)|LUSC - Lung squamous cell carcinoma(625;0.122)		AGGCAGCAGGGGTTCATGAAG	0.632000													4	135					0.184627	0.186893	1	1	0
ANKRD30BL	554226	broad.mit.edu	37	2	132919171	132919171	+	RNA	SNP	A	A	G	rs148383954	by1000genomes	TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr2:132919171A>G	uc002tti.3	-	0		c.355T>C			ANKRD30BL_uc002ttj.3_Intron					Homo sapiens ankyrin repeat domain 30B-like (ANKRD30BL), transcript variant 1, non-coding RNA.											endometrium(1)|kidney(3)	4						TGAGATCCCCATGGTGAATCA	0.582000													10	244					0	0	1	0	0
TGM7	116179	broad.mit.edu	37	15	43585144	43585144	+	Missense_Mutation	SNP	G	G	T			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr15:43585144G>T	uc001zrf.1	-	2	207	c.202C>A	c.(202-204)Ccg>Acg	p.P68T		NM_052955	NP_443187	Q96PF1	TGM7_HUMAN	Homo sapiens transglutaminase 7 (TGM7), mRNA.	68					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(2)|prostate(4)|skin(1)	39		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	AGCTCTGACGGCTTGGGTCCT	0.557000													14	39					0.00185496	0.00198745	1	1	0
PDZD7	79955	broad.mit.edu	37	10	102783355	102783355	+	Missense_Mutation	SNP	A	A	G			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr10:102783355A>G	uc001ksn.3	-	3	630	c.380T>C	c.(379-381)cTg>cCg	p.L127P	PDZD7_uc021pxc.1_Missense_Mutation_p.L127P|PDZD7_uc001kso.2_Missense_Mutation_p.L127P	NM_024895	NP_079171	Q9H5P4	PDZD7_HUMAN	Homo sapiens PDZ domain containing 7 (PDZD7), transcript variant 2, mRNA.	127	PDZ 1.					cilium|nucleus	protein binding			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(7)|ovary(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22				Epithelial(162;6.98e-09)|all cancers(201;3.55e-07)		CCCCACGCACAGGCCAGCCCG	0.657000													11	17					0	0	1	0	0
LYZL6	57151	broad.mit.edu	37	17	34263772	34263772	+	Missense_Mutation	SNP	C	C	G			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr17:34263772C>G	uc002hkj.2	-	2	564	c.364G>C	c.(364-366)Ggg>Cgg	p.G122R	LYZL6_uc002hkk.2_Missense_Mutation_p.G122R	NM_020426	NP_065159	O75951	LYZL6_HUMAN	Homo sapiens lysozyme-like 6 (LYZL6), transcript variant 2, mRNA.	122					cell wall macromolecule catabolic process	extracellular region	lysozyme activity	p.G122V(2)		breast(1)|endometrium(1)|large_intestine(1)|lung(8)|stomach(1)	12				UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TTGTTCATCCCCCGTGCTCCG	0.572000													47	39					0	0	1	0	0
SLC43A3	29015	broad.mit.edu	37	11	57182149	57182149	+	Silent	SNP	G	G	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr11:57182149G>A	uc010rjr.2	-	10	1380	c.1038C>T	c.(1036-1038)ccC>ccT	p.P346P	SLC43A3_uc001nke.3_Silent_p.P232P|SLC43A3_uc001nkg.3_Silent_p.P333P|SLC43A3_uc001nkh.3_Silent_p.P333P|SLC43A3_uc009yme.3_Silent_p.P333P|SLC43A3_uc001nki.3_Silent_p.P333P|SLC43A3_uc009ymf.1_Silent_p.P333P	NM_199329	NP_955361	Q8NBI5	S43A3_HUMAN	Homo sapiens solute carrier family 43, member 3 (SLC43A3), mRNA.	333					transmembrane transport	integral to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(10)|lung(4)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	27						GGCCATTCCAGGGGGCACACA	0.537000													51	97					0	0	1	0	0
PNCK	139728	broad.mit.edu	37	X	152938523	152938523	+	Silent	SNP	C	C	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chrX:152938523C>A	uc011myu.2	-	1	444	c.258G>T	c.(256-258)ctG>ctT	p.L86L	PNCK_uc011myt.2_Silent_p.L20L|PNCK_uc004fhz.4_5'UTR|PNCK_uc010nuh.2_Silent_p.L86L|PNCK_uc011myv.2_5'UTR|PNCK_uc011myw.2_5'UTR	NM_001039582	NP_001034671	Q6P2M8	KCC1B_HUMAN	Homo sapiens pregnancy up-regulated non-ubiquitously expressed CaM kinase (PNCK), transcript variant 1, mRNA.	3	Protein kinase.					cytoplasm|nucleus	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			breast(2)|lung(3)|skin(1)	6	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GTTTCTTCAGCAGCAGCATGT	0.667000													4	176					0.184627	0.186893	1	1	0
PTCHD4	442213	broad.mit.edu	37	6	48036108	48036108	+	Missense_Mutation	SNP	T	T	C			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr6:48036108T>C	uc011dwm.2	-	0	318	c.284A>G	c.(283-285)gAc>gGc	p.D95G	PTCHD4_uc011dwn.2_Intron|PTCHD4_uc003ozf.2_Missense_Mutation_p.D95G	NM_001013732	NP_001013754	Q6ZW05	CF138_HUMAN	Homo sapiens chromosome 6 open reading frame 138 (C6orf138), transcript variant 1, mRNA.	95						integral to membrane	hedgehog receptor activity										TTTGGACTGGTCCAGGGGGAA	0.627000													17	290					0	0	1	0	0
FAM5B	57795	broad.mit.edu	37	1	177242681	177242690	+	Frame_Shift_Del	DEL	GTCAGTTCTG	GTCAGTTCTG	-	rs138487282		TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr1:177242681_177242690delGTCAGTTCTG	uc001glf.3	+	4	1039_1048	c.727_736delGTCAGTTCTG	c.(727-738)gtcagttctgtcfs	p.V243fs	FAM5B_uc010pna.1_5'UTR|FAM5B_uc001glg.3_Frame_Shift_Del_p.V138fs	NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	Homo sapiens family with sequence similarity 5, member B (FAM5B), mRNA.	243						extracellular region				breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						TCTGGACTCAGTCAGTTCTGTCTTGGTACA	0.443													18	164	---	---	---	---					
CNPY3	10695	broad.mit.edu	37	6	42897358	42897360	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr6:42897358_42897360delTGC	uc003ota.4	+	0	499_501	c.50_52delTGC	c.(49-54)ttgctg>ttg	p.17_18LL>L	CNPY3_uc003osy.2_Non-coding_Transcript|CNPY3_uc003otb.4_5'UTR	NM_006586	NP_006577	Q9BT09	CNPY3_HUMAN	Homo sapiens canopy 3 homolog (zebrafish) (CNPY3), mRNA.	17					innate immune response	endoplasmic reticulum		p.L25delL(1)		central_nervous_system(1)|endometrium(1)|lung(3)|ovary(1)	6	Colorectal(47;0.196)		all cancers(41;0.000954)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|OV - Ovarian serous cystadenocarcinoma(102;0.0218)|Kidney(15;0.0388)			CTTCTTCCCTtgctgctgctgct	0.695													7	122	---	---	---	---					
PKHD1	5314	broad.mit.edu	37	6	51890186	51890186	+	Frame_Shift_Del	DEL	C	C	-			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr6:51890186delC	uc003pah.1	-	31	4698	c.4422delG	c.(4420-4422)gggfs	p.G1474fs	PKHD1_uc003pai.3_Frame_Shift_Del_p.G1474fs	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	Homo sapiens polycystic kidney and hepatic disease 1 (autosomal recessive) (PKHD1), transcript variant 1, mRNA.	1474	IPT/TIG 9.				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			NS(1)|autonomic_ganglia(1)|breast(8)|central_nervous_system(5)|cervix(1)|endometrium(16)|haematopoietic_and_lymphoid_tissue(4)|kidney(11)|large_intestine(59)|lung(139)|ovary(16)|prostate(8)|skin(20)|soft_tissue(1)|stomach(2)|upper_aerodigestive_tract(7)|urinary_tract(5)	304	Lung NSC(77;0.0605)					GAGTGCAATTCCCCTGACACT	0.542													53	187	---	---	---	---					
LRRC1	55227	broad.mit.edu	37	6	53764574	53764575	+	Frame_Shift_Del	DEL	TT	TT	-			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr6:53764574_53764575delTT	uc003pcd.1	+	7	1193_1194	c.672_673delTT	c.(670-675)tgtttafs	p.C224fs		NM_018214	NP_060684	Q9BTT6	LRRC1_HUMAN	Homo sapiens leucine rich repeat containing 1 (LRRC1), mRNA.	224						cytoplasm|membrane				cervix(1)|endometrium(3)|large_intestine(5)|lung(6)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	20	Lung NSC(77;0.0147)			BRCA - Breast invasive adenocarcinoma(397;0.0745)		ACCTGCTGTGTTTAGATGTCTC	0.391													32	378	---	---	---	---					
AGR3	155465	broad.mit.edu	37	7	16901068	16901068	+	Frame_Shift_Del	DEL	C	C	-			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr7:16901068delC	uc003sts.3	-	5	380	c.307delG	c.(307-309)gaafs	p.E103fs		NM_176813	NP_789783	Q8TD06	AGR3_HUMAN	Homo sapiens anterior gradient 3 homolog (Xenopus laevis) (AGR3), mRNA.	103						extracellular region				central_nervous_system(1)|kidney(8)|lung(2)|skin(1)|stomach(1)	13	Lung NSC(10;0.0376)|all_lung(11;0.0721)|all_epithelial(12;0.202)			UCEC - Uterine corpus endometrioid carcinoma (126;0.184)		TCAGTGGTTTCATGCTAGCAG	0.323													9	197	---	---	---	---					
KIAA1324L	222223	broad.mit.edu	37	7	86577110	86577110	+	Frame_Shift_Del	DEL	A	A	-			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr7:86577110delA	uc011kha.2	-	2	624	c.439delT	c.(439-441)tctfs	p.S147fs	KIAA1324L_uc003uie.3_Intron|KIAA1324L_uc011kgz.2_Frame_Shift_Del_p.S33fs|KIAA1324L_uc003uif.2_Intron	NM_001142749	NP_001136221	A8MWY0	K132L_HUMAN	Homo sapiens KIAA1324-like (KIAA1324L), transcript variant 1, mRNA.	147						integral to membrane				breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(14)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44	Esophageal squamous(14;0.0058)					GCGATGTTAGAAAATCCTGCC	0.473													64	114	---	---	---	---					
MLL3	58508	broad.mit.edu	37	7	152012386	152012386	+	Frame_Shift_Del	DEL	T	T	-			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr7:152012386delT	uc003wla.3	-	3	646	c.427delA	c.(427-429)agtfs	p.S143fs		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	Homo sapiens myeloid/lymphoid or mixed-lineage leukemia 3 (MLL3), mRNA.	143					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			NS(6)|biliary_tract(9)|breast(24)|central_nervous_system(18)|cervix(6)|endometrium(31)|haematopoietic_and_lymphoid_tissue(1)|kidney(26)|large_intestine(52)|liver(1)|lung(102)|ovary(10)|pancreas(17)|prostate(15)|skin(20)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(8)|urinary_tract(15)	365	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CCTAAGGAACTTTTTTCCCCA	0.378			N		medulloblastoma								52	92	---	---	---	---					
LURAP1L	286343	broad.mit.edu	37	9	12775861	12775862	+	In_Frame_Ins	INS	-	-	GGCGGC	rs3833707	by1000genomes	TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr9:12775861_12775862insGGCGGC	uc003zkw.3	+	0	850_851	c.147_148insGGCGGC	c.(145-150)insGGCGGC	p.55_56insGG		NM_203403	NP_981948	Q8IV03	CI150_HUMAN	Homo sapiens chromosome 9 open reading frame 150 (C9orf150), mRNA.	58	Gly-rich.							p.G49_G50insGGG(2)|p.G50_G52delGGG(1)									gcggtggtggtggcggcggcgg	0.688													18	52	---	---	---	---					
CIZ1	25792	broad.mit.edu	37	9	130947865	130947865	+	Frame_Shift_Del	DEL	T	T	-			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr9:130947865delT	uc011mas.2	-	4	804	c.639delA	c.(637-639)aaafs	p.K213fs	CIZ1_uc004btr.3_Frame_Shift_Del_p.K183fs|CIZ1_uc004bts.3_Frame_Shift_Del_p.K159fs|CIZ1_uc011maq.2_Frame_Shift_Del_p.K183fs|CIZ1_uc004btu.3_Frame_Shift_Del_p.K159fs|CIZ1_uc004btt.3_Frame_Shift_Del_p.K183fs|CIZ1_uc011mar.2_Frame_Shift_Del_p.K82fs|CIZ1_uc004btw.3_Frame_Shift_Del_p.K183fs|CIZ1_uc004btv.3_Frame_Shift_Del_p.K183fs|CIZ1_uc004btx.2_Frame_Shift_Del_p.K159fs	NM_012127	NP_036259	Q9ULV3	CIZ1_HUMAN	Homo sapiens CDKN1A interacting zinc finger protein 1 (CIZ1), transcript variant 1, mRNA.	183						nucleus	nucleic acid binding|protein binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(8)|liver(1)|lung(9)|ovary(3)|prostate(2)|urinary_tract(2)	35						TCCGGGCCTGTTTCTGGGGGT	0.637													36	83	---	---	---	---					
DLAT	1737	broad.mit.edu	37	11	111904183	111904183	+	Frame_Shift_Del	DEL	A	A	-			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr11:111904183delA	uc001pmo.3	+	4	1375	c.716delA	c.(715-717)gaafs	p.E239fs	DLAT_uc010rwr.2_Intron|DLAT_uc021qqn.1_Frame_Shift_Del_p.E183fs	NM_001931	NP_001922	P10515	ODP2_HUMAN	Homo sapiens dihydrolipoamide S-acetyltransferase (DLAT), nuclear gene encoding mitochondrial protein, mRNA.	239	Lipoyl-binding 2.				glycolysis|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial pyruvate dehydrogenase complex	dihydrolipoyllysine-residue acetyltransferase activity|protein binding			breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(10)|ovary(1)|skin(1)	22		all_cancers(61;4.53e-11)|all_epithelial(67;2.76e-06)|Melanoma(852;9.42e-06)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Breast(348;0.0512)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)		Epithelial(105;4.87e-07)|BRCA - Breast invasive adenocarcinoma(274;6.83e-07)|all cancers(92;9.63e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0557)	NADH(DB00157)	CAGAGATGGGAAAAAAAAGTG	0.433													7	205	---	---	---	---					
DDX12P	440081	broad.mit.edu	37	12	9573309	9573309	+	RNA	DEL	G	G	-	rs66804813		TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr12:9573309delG	uc021qut.1	-	10		c.2089delC			DDX12P_uc001qvx.4_Intron|DDX12P_uc001qvy.1_5'Flank					Homo sapiens DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 12, pseudogene (DDX12P), non-coding RNA.																		gagggagggagCCCCCATGGA	0.582													11	31	---	---	---	---					
TCP11L2	255394	broad.mit.edu	37	12	106729801	106729811	+	Splice_Site	DEL	ATATGTTAGAC	ATATGTTAGAC	-			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr12:106729801_106729811delATATGTTAGAC	uc001tln.3	+	8	1135	c.961_splice	c.e8-1	p.T321_splice		NM_152772	NP_689985	Q8N4U5	T11L2_HUMAN	Homo sapiens t-complex 11 (mouse)-like 2 (TCP11L2), mRNA.	321										endometrium(2)|kidney(2)|large_intestine(5)|ovary(3)|prostate(1)|urinary_tract(2)	15						ttttaaataaatatGTTAGACACTTATGACA	0.327													7	15	---	---	---	---					
CUX2	23316	broad.mit.edu	37	12	111785758	111785759	+	Frame_Shift_Ins	INS	-	-	A			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr12:111785758_111785759insA	uc001tsa.2	+	21	4244_4245	c.4090_4091insA	c.(4090-4092)caafs	p.Q1364fs		NM_015267	NP_056082	O14529	CUX2_HUMAN	Homo sapiens cut-like homeobox 2 (CUX2), mRNA.	1364	Pro-rich.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						ACTTCATCCCCAACAGGAGAGT	0.604													24	44	---	---	---	---					
MEF2A	4205	broad.mit.edu	37	15	100252710	100252712	+	In_Frame_Del	DEL	CAG	CAG	-	rs72276751		TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr15:100252710_100252712delCAG	uc010urw.2	+	10	1617_1619	c.1258_1260delCAG	c.(1258-1260)cagdel	p.Q430del	MEF2A_uc002bve.3_In_Frame_Del_p.Q428del|MEF2A_uc002bvg.3_In_Frame_Del_p.Q420del|MEF2A_uc010urv.2_In_Frame_Del_p.Q360del|MEF2A_uc010bos.3_In_Frame_Del_p.Q420del|MEF2A_uc002bvf.3_In_Frame_Del_p.Q422del|MEF2A_uc002bvi.3_In_Frame_Del_p.Q420del|MEF2A_uc010bot.3_In_Frame_Del_p.Q352del	NM_005587	NP_005578	Q02078	MEF2A_HUMAN	Homo sapiens myocyte enhancer factor 2A (MEF2A), transcript variant 1, mRNA.	430	Gln/Pro-rich.			Missing (in Ref. 4; AAB17195/AAB17196).	BMK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|Toll signaling pathway|apoptosis|cardiac conduction|cellular response to calcium ion|dendrite morphogenesis|innate immune response|mitochondrial genome maintenance|mitochondrion distribution|muscle organ development|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of muscle cell differentiation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|ventricular cardiac myofibril development	nuclear chromatin|nucleoplasm	RNA polymerase II regulatory region sequence-specific DNA binding|SMAD binding|activating transcription factor binding|histone acetyltransferase binding|histone deacetylase binding|protein heterodimerization activity|sequence-specific DNA binding RNA polymerase II transcription factor activity			endometrium(2)|large_intestine(2)|lung(7)|ovary(1)	12	Lung NSC(78;0.00335)|all_lung(78;0.00659)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00085)			ATCGGGCTTCcagcagcagcagc	0.606													19	61	---	---	---	---					
ZFHX3	463	broad.mit.edu	37	16	72923790	72923790	+	Frame_Shift_Del	DEL	G	G	-			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr16:72923790delG	uc002fck.3	-	3	3961	c.3288delC	c.(3286-3288)tccfs	p.S1096fs	ZFHX3_uc002fcl.3_Frame_Shift_Del_p.S182fs	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	Homo sapiens zinc finger homeobox 3 (ZFHX3), transcript variant A, mRNA.	1096					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				TGGCCTTGGTGGAGTAGTTGC	0.557													14	28	---	---	---	---					
ZFPM1	161882	broad.mit.edu	37	16	88599696	88599697	+	Frame_Shift_Del	DEL	GA	GA	-	rs67549438		TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr16:88599696_88599697delGA	uc002fkv.3	+	9	1363_1364	c.1330_1331delGA	c.(1330-1332)gagfs	p.E444fs		NM_153813	NP_722520	Q8IX07	FOG1_HUMAN	Homo sapiens zinc finger protein, multitype 1 (ZFPM1), mRNA.	444				EPLA -> AP (in Ref. 1; AAN45858).	blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|transcription factor binding|zinc ion binding			central_nervous_system(1)|ovary(2)|urinary_tract(1)	4				BRCA - Breast invasive adenocarcinoma(80;0.0478)		GGCCAGAGCGGAGCCTCTGGCC	0.743													8	37	---	---	---	---					
ZFPM1	161882	broad.mit.edu	37	16	88599701	88599701	+	Frame_Shift_Del	DEL	T	T	-	rs67322929		TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr16:88599701delT	uc002fkv.3	+	9	1368	c.1335delT	c.(1333-1335)cctfs	p.P445fs		NM_153813	NP_722520	Q8IX07	FOG1_HUMAN	Homo sapiens zinc finger protein, multitype 1 (ZFPM1), mRNA.	445				EPLA -> AP (in Ref. 1; AAN45858).	blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|transcription factor binding|zinc ion binding			central_nervous_system(1)|ovary(2)|urinary_tract(1)	4				BRCA - Breast invasive adenocarcinoma(80;0.0478)		GAGCGGAGCCTCTGGCCCAGA	0.746													8	35	---	---	---	---					
ZFPM1	161882	broad.mit.edu	37	16	88599703	88599705	+	In_Frame_Del	DEL	TGG	TGG	-	rs67873604		TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr16:88599703_88599705delTGG	uc002fkv.3	+	9	1370_1372	c.1337_1339delTGG	c.(1336-1341)ctggcc>ccc	p.446_447LA>P		NM_153813	NP_722520	Q8IX07	FOG1_HUMAN	Homo sapiens zinc finger protein, multitype 1 (ZFPM1), mRNA.	446				EPLA -> AP (in Ref. 1; AAN45858).	blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|transcription factor binding|zinc ion binding			central_nervous_system(1)|ovary(2)|urinary_tract(1)	4				BRCA - Breast invasive adenocarcinoma(80;0.0478)		GCGGAGCCTCTGGCCCAGAATGG	0.739													8	33	---	---	---	---					
B9D2	80776	broad.mit.edu	37	19	41869392	41869392	+	Frame_Shift_Del	DEL	T	T	-	rs2241714	byFrequency	TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr19:41869392delT	uc002oqj.2	-	1	253	c.33delA	c.(31-33)atafs	p.I11fs	BCKDHA_uc002oqi.3_Intron|BCKDHA_uc010ehq.3_5'Flank	NM_030578	NP_085055	Q9BPU9	B9D2_HUMAN	Homo sapiens B9 protein domain 2 (B9D2), mRNA.	11	B9.		I -> M (in dbSNP:rs2241714).		cilium assembly|mitotic prometaphase	centrosome|cilium axoneme|cytosol|microtubule basal body|nucleus	gamma-tubulin binding			large_intestine(1)|ovary(1)	2						CGCTGGCCCCTATGATCTGCC	0.537													67	58	---	---	---	---					
HSPBP1	23640	broad.mit.edu	37	19	55790886	55790887	+	In_Frame_Ins	INS	-	-	GCCGCCGCC	rs10701478	by1000genomes	TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr19:55790886_55790887insGCCGCCGCC	uc002qkd.3	-	2	424_425	c.90_91insGGCGGCGGC	c.(88-93)insGGCGGCGGC	p.30_31insGGG	HSPBP1_uc002qjx.3_In_Frame_Ins_p.76_77insGGG|HSPBP1_uc002qkc.3_In_Frame_Ins_p.30_31insGGG|BRSK1_uc002qkf.3_5'Flank	NM_001130106	NP_036399	Q9NZL4	HPBP1_HUMAN	Homo sapiens HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1 (HSPBP1), transcript variant 2, mRNA.	30	Gly-rich.				positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein ubiquitination|protein folding		enzyme inhibitor activity|protein binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|prostate(1)|urinary_tract(1)	8			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0452)		CCAGCCGAGGAGCCGCCGCCGC	0.713													16	13	---	---	---	---					
PPP4R1L	55370	broad.mit.edu	37	20	56813334	56813337	+	RNA	DEL	AAAG	AAAG	-			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr20:56813334_56813337delAAAG	uc002xyw.3	-	5		c.1139_1142delCTTT			PPP4R1L_uc010gjn.1_Non-coding_Transcript					Homo sapiens protein phosphatase 4, regulatory subunit 1-like (PPP4R1L), non-coding RNA.																		TGAAGCTGATAAAGATAGTCTCTC	0.333													22	24	---	---	---	---					
OLIG1	116448	broad.mit.edu	37	21	34442709	34442717	+	In_Frame_Del	DEL	TCCTCCACT	TCCTCCACT	-			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chr21:34442709_34442717delTCCTCCACT	uc002yqz.3	+	0	260_268	c.157_165delTCCTCCACT	c.(157-165)tcctccactdel	p.SST53del		NM_138983	NP_620450	Q8TAK6	OLIG1_HUMAN	Homo sapiens oligodendrocyte transcription factor 1 (OLIG1), mRNA.	53	Ser-rich.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			central_nervous_system(1)	1						ctcctccacctcctccacttcctcctcct	0.746													7	9	---	---	---	---					
GPR112	139378	broad.mit.edu	37	X	135475736	135475737	+	Frame_Shift_Ins	INS	-	-	AAAAT			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chrX:135475736_135475737insAAAAT	uc004ezu.1	+	17	8368_8369	c.8077_8078insAAAAT	c.(8077-8079)aatfs	p.N2693fs	GPR112_uc010nsb.1_Frame_Shift_Ins_p.N2488fs	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	Homo sapiens G protein-coupled receptor 112 (GPR112), mRNA.	2693	GPS.				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(2)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(17)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(33)|lung(97)|ovary(5)|pancreas(2)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(2)	199	Acute lymphoblastic leukemia(192;0.000127)					TTTTGAGAATAATAGTAAGTAT	0.371													16	42	---	---	---	---					
GABRQ	55879	broad.mit.edu	37	X	151808889	151808890	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-Q2-A5QZ-01A-11D-A28G-10	TCGA-Q2-A5QZ-10A-01D-A28G-10								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b249fd0e-a8a3-4d18-b3a2-16901434f261	1b6d1224-f192-4682-9d71-3c30ffcd4589	g.chrX:151808889_151808890delTG	uc004ffp.1	+	1	220_221	c.200_201delTG	c.(199-201)ctgfs	p.L67fs		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	Homo sapiens gamma-aminobutyric acid (GABA) receptor, theta (GABRQ), mRNA.	67						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	GABA-A receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|neurotransmitter transporter activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(4)|large_intestine(9)|lung(25)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	52	Acute lymphoblastic leukemia(192;6.56e-05)					GACAGGGTGCTGTCAAGATACG	0.470													56	104	---	---	---	---					
