Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
C1orf94	84970	broad.mit.edu	37	1	34684353	34684353	+	Silent	SNP	A	A	C			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr1:34684353A>C	ENST00000488417.1	+	7	1908	c.1788A>C	c.(1786-1788)atA>atC	p.I596I	C1orf94_ENST00000373374.3_Silent_p.I406I	NM_001134734.1	NP_001128206.1	Q6P1W5	CA094_HUMAN	chromosome 1 open reading frame 94	406							protein binding			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(5)|lung(15)|skin(4)|upper_aerodigestive_tract(2)	32		Myeloproliferative disorder(586;0.0393)				GGAATGGCATAAACTTTTAGA	0.502000													9	86					0	0	0.008291	0	0
PPP1R14C	81706	broad.mit.edu	37	6	150569956	150569956	+	Nonstop_Mutation	SNP	A	A	C			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr6:150569956A>C	ENST00000361131.4	+	4	615	c.498A>C	c.(496-498)tgA>tgC	p.*166C		NM_030949.2	NP_112211.1	Q8TAE6	PP14C_HUMAN	protein phosphatase 1, regulatory (inhibitor) subunit 14C	0					regulation of phosphorylation	cytoplasm|membrane				endometrium(1)|large_intestine(1)|prostate(1)	3		Ovarian(120;0.0284)	BRCA - Breast invasive adenocarcinoma(37;0.215)	OV - Ovarian serous cystadenocarcinoma(155;9.14e-12)		AGAGTGTATGATTCTGGAACA	0.413000													4	33					0	0	0.000602	0	0
NT5C3B	115024	broad.mit.edu	37	17	39983679	39983679	+	Splice_Site	SNP	T	T	C			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr17:39983679T>C	ENST00000269534.8	-	8	844	c.744_splice	c.e8+1	p.K248_splice	NT5C3B_ENST00000521789.1_Intron|NT5C3B_ENST00000435506.2_Splice_Site_p.K256_splice	NM_052935.4	NP_443167.4			5'-nucleotidase, cytosolic IIIB																		TCTACCCACCTTGTCATTCAG	0.453000													6	106					0	0	0.003080	0	0
CCDC108	255101	broad.mit.edu	37	2	219892530	219892530	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr2:219892530T>C	ENST00000341552.5	-	13	2136	c.2053A>G	c.(2053-2055)Atg>Gtg	p.M685V	CCDC108_ENST00000441968.1_Missense_Mutation_p.M685V|CCDC108_ENST00000453220.1_Missense_Mutation_p.M685V|CCDC108_ENST00000410037.1_Missense_Mutation_p.M620V|CCDC108_ENST00000409865.3_Missense_Mutation_p.M674V	NM_194302.2	NP_919278.2	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108	685						integral to membrane	structural molecule activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(18)|liver(1)|lung(34)|ovary(2)|pancreas(1)|prostate(6)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	80		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CAGACCACCATGATCTTGCCC	0.622000													13	47					0	0	0.001368	0	0
PPFIBP2	8495	broad.mit.edu	37	11	7670431	7670431	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr11:7670431A>G	ENST00000299492.4	+	20	2351	c.1963A>G	c.(1963-1965)Aga>Gga	p.R655G	PPFIBP2_ENST00000530582.1_3'UTR|PPFIBP2_ENST00000530181.1_Missense_Mutation_p.R512G|PPFIBP2_ENST00000528883.1_Missense_Mutation_p.R543G|PPFIBP2_ENST00000533792.1_Missense_Mutation_p.R497G	NM_003621.3	NP_003612.2	Q8ND30	LIPB2_HUMAN	PTPRF interacting protein, binding protein 2 (liprin beta 2)	655	SAM 2.				cell communication|DNA integration	intracellular	DNA binding|integrase activity|protein binding			breast(8)|cervix(1)|kidney(1)|large_intestine(8)|lung(8)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	32				Epithelial(150;2.01e-07)|BRCA - Breast invasive adenocarcinoma(625;0.236)		TCATGAATCTAGAGTTGACAG	0.428000													4	58					0	0	0.000248	0	0
HSD17B7P2	0	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													7	68					0	0	0.001984	0	0
PIK3CA	5290	broad.mit.edu	37	3	178952050	178952050	+	Silent	SNP	T	T	G			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr3:178952050T>G	ENST00000263967.3	+	21	3262	c.3105T>G	c.(3103-3105)gcT>gcG	p.A1035A		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	1035	PI3K/PI4K.		A -> V (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity			NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AGCAAGAGGCTTTGGAGTATT	0.393000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			4	40					0	0	0.000248	0	0
POLR3A	11128	broad.mit.edu	37	10	79781714	79781714	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr10:79781714C>T	ENST00000372371.3	-	7	1089	c.952G>A	c.(952-954)Gcc>Acc	p.A318T		NM_007055.3	NP_008986.2	O14802	RPC1_HUMAN	polymerase (RNA) III (DNA directed) polypeptide A, 155kDa	318					innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity|ribonucleoside binding|zinc ion binding			breast(1)|endometrium(7)|kidney(3)|large_intestine(13)|lung(25)|ovary(1)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	all_cancers(46;0.0356)|all_epithelial(25;0.00102)|Breast(12;0.00124)|Prostate(51;0.0095)		Epithelial(14;0.00161)|OV - Ovarian serous cystadenocarcinoma(4;0.00323)|all cancers(16;0.00646)			ATGTAGAGGGCACACTGCAGC	0.532000													7	53					0	0	0.001984	0	0
ETFDH	2110	broad.mit.edu	37	4	159601637	159601637	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr4:159601637C>T	ENST00000511912.1	+	2	385	c.53C>T	c.(52-54)gCc>gTc	p.A18V	ETFDH_ENST00000307738.5_Intron	NM_004453.2	NP_004444.2	Q16134	ETFD_HUMAN	electron-transferring-flavoprotein dehydrogenase	18					fatty acid beta-oxidation using acyl-CoA dehydrogenase|respiratory electron transport chain|response to oxidative stress|transport	integral to mitochondrial inner membrane|mitochondrial matrix	4 iron, 4 sulfur cluster binding|electron carrier activity|electron-transferring-flavoprotein dehydrogenase activity|flavin adenine dinucleotide binding|metal ion binding|oxidoreductase activity, oxidizing metal ions with flavin as acceptor|ubiquinone binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(13)|prostate(1)|skin(3)	28	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0172)		TGCTTTCATGCCTTAAAAATT	0.318000													5	33					0	0	0.000602	0	0
RP1	6101	broad.mit.edu	37	8	55542773	55542773	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr8:55542773G>A	ENST00000220676.1	+	4	6479	c.6331G>A	c.(6331-6333)Gtt>Att	p.V2111I		NM_006269.1	NP_006260.1	P56715	RP1_HUMAN	retinitis pigmentosa 1 (autosomal dominant)	2111					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding	p.V2111I(1)		NS(4)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(29)|lung(69)|ovary(6)|pancreas(1)|prostate(9)|skin(17)|upper_aerodigestive_tract(3)|urinary_tract(2)	169		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TATTTGCCAAGTTGAGACCTC	0.333000													10	56					0	0	0.001368	0	0
CHI3L1	1116	broad.mit.edu	37	1	203152888	203152888	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr1:203152888G>A	ENST00000255409.3	-	5	471	c.346C>T	c.(346-348)Cgc>Tgc	p.R116C		NM_001276.2	NP_001267.2	P36222	CH3L1_HUMAN	chitinase 3-like 1 (cartilage glycoprotein-39)	116					chitin catabolic process	extracellular space|proteinaceous extracellular matrix	cation binding|chitinase activity|extracellular matrix structural constituent|sugar binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|pancreas(1)|skin(1)	18						AAAGTCCGGCGACTCTGGGTG	0.552000													5	91					0	0	0.000602	0	0
ZNF394	84124	broad.mit.edu	37	7	99096409	99096409	+	Silent	SNP	G	G	A			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr7:99096409G>A	ENST00000337673.6	-	2	716	c.513C>T	c.(511-513)cgC>cgT	p.R171R	ZNF394_ENST00000426306.2_Intron|ZNF789_ENST00000494186.1_Intron|ZNF789_ENST00000493485.1_Intron|ZNF394_ENST00000394177.3_5'UTR	NM_032164.2	NP_115540.2	Q53GI3	ZN394_HUMAN	zinc finger protein 394	171	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(1)|lung(5)|stomach(1)|urinary_tract(1)	16	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					CTGGGTCCAGGCGCTCCCACT	0.582000													5	56					0	0	0.001168	0	0
OR2B11	127623	broad.mit.edu	37	1	247615283	247615283	+	Translation_Start_Site	SNP	A	A	T			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr1:247615283A>T	ENST00000318749.6	-	1	25	c.2T>A	c.(1-3)aTg>aAg	p.M1K		NM_001004492.1	NP_001004492.1	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B, member 11	1					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(13)|large_intestine(7)|lung(31)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	60	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			GTCACTTTTCATGTTGCGGCA	0.473000													8	45					0	0	0.004482	0	0
TP53AIP1	63970	broad.mit.edu	37	11	128807545	128807545	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr11:128807545C>A	ENST00000602346.1	-	2	378	c.169G>T	c.(169-171)Ggt>Tgt	p.G57C	TP53AIP1_ENST00000458238.2_Intron|TP53AIP1_ENST00000531399.1_Intron|TP53AIP1_ENST00000530777.1_Intron	NM_001251964.1	NP_001238893.1	Q9HCN2	TPIP1_HUMAN	tumor protein p53 regulated apoptosis inducing protein 1	0					apoptosis	mitochondrion				large_intestine(1)|lung(1)|skin(1)	3						GGCAAAAGACCGTCTCGGTTT	0.607000													13	88					0.000308642	0.000591564	0.003163	1	0
SP4	6671	broad.mit.edu	37	7	21521732	21521732	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr7:21521732A>G	ENST00000222584.3	+	5	2316	c.2098A>G	c.(2098-2100)Acc>Gcc	p.T700A		NM_003112.3	NP_003103.2	Q02446	SP4_HUMAN	Sp4 transcription factor	700					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|lung(11)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	35						ACATAGAAGAACCCATACAGG	0.348000													6	66					0	0	0.001984	0	0
GJB4	127534	broad.mit.edu	37	1	35226969	35226969	+	Silent	SNP	G	G	A			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr1:35226969G>A	ENST00000339480.1	+	2	484	c.114G>A	c.(112-114)gtG>gtA	p.V38V		NM_153212.2	NP_694944.1	Q9NTQ9	CXB4_HUMAN	gap junction protein, beta 4, 30.3kDa	38					cell communication	connexon complex|integral to membrane	gap junction channel activity			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(1)|lung(6)|ovary(2)|skin(1)	16		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.234)				TGTACGTGGTGGCAGCGGAGG	0.582000													6	47					0	0	0.003080	0	0
EFCAB6	64800	broad.mit.edu	37	22	44127674	44127674	+	Missense_Mutation	SNP	T	T	C	rs150224112		TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr22:44127674T>C	ENST00000262726.7	-	8	915	c.662A>G	c.(661-663)aAc>aGc	p.N221S	EFCAB6_ENST00000396231.2_Missense_Mutation_p.N69S|EFCAB6_ENST00000358439.4_Missense_Mutation_p.N115S|EFCAB6_ENST00000356087.4_Missense_Mutation_p.N115S	NM_022785.3	NP_073622.2	Q5THR3	EFCB6_HUMAN	EF-hand calcium binding domain 6	221					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			breast(1)|cervix(1)|endometrium(6)|kidney(2)|large_intestine(16)|lung(25)|ovary(4)|pancreas(1)|prostate(4)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68		Ovarian(80;0.0247)|all_neural(38;0.025)				CTTGTGGATGTTGTAGTGTTT	0.323000													4	36					0	0	0.000602	0	0
GUF1	60558	broad.mit.edu	37	4	44692859	44692859	+	Missense_Mutation	SNP	A	A	C			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr4:44692859A>C	ENST00000281543.5	+	12	1655	c.1461A>C	c.(1459-1461)aaA>aaC	p.K487N	GUF1_ENST00000506793.1_3'UTR	NM_021927.2	NP_068746.2	Q8N442	GUF1_HUMAN	GUF1 GTPase homolog (S. cerevisiae)	487					translation	mitochondrial inner membrane	GTP binding|GTPase activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	19						ACACTGGAAAAATAATGATGC	0.318000													8	87					0	0	0.006214	0	0
ENKD1	84080	broad.mit.edu	37	16	67700164	67700164	+	Silent	SNP	T	T	C			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr16:67700164T>C	ENST00000243878.4	-	2	411	c.90A>G	c.(88-90)caA>caG	p.Q30Q	ENKD1_ENST00000602644.1_Silent_p.Q30Q	NM_032140.1	NP_115516.1			enkurin domain containing 1																		CGAGGCGCCCTTGAGCTGTGG	0.731000													7	30					0	0	0.001984	0	0
GSDMC	56169	broad.mit.edu	37	8	130762274	130762274	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr8:130762274G>A	ENST00000276708.4	-	12	2056	c.1175C>T	c.(1174-1176)cCa>cTa	p.P392L		NM_031415.2	NP_113603.1	Q9BYG8	GSDMC_HUMAN	gasdermin C	392						mitochondrion				autonomic_ganglia(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|pancreas(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(1)	26						GGGGTCCTTTGGGTTAAACCA	0.448000													4	17					0	0	0.000248	0	0
IGKV1-8	0	broad.mit.edu	37	2	89292205	89292205	+	RNA	SNP	C	C	T			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr2:89292205C>T	ENST00000495489.1	-	0	120																											CTGGGTCATCCGGATGGCACA	0.463000													23	226					0	0	0.003330	0	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803480	142803480	+	RNA	SNP	T	T	C			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr1:142803480T>C	ENST00000423385.1	-	0	1485																											GATTTTAATATTCTGTACATT	0.343000													6	27					0	0	0.001168	0	0
TBP	6908	broad.mit.edu	37	6	170871088	170871088	+	Silent	SNP	G	G	A			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr6:170871088G>A	ENST00000392092.2	+	3	543	c.264G>A	c.(262-264)caG>caA	p.Q88Q	TBP_ENST00000540980.1_Silent_p.Q68Q|TBP_ENST00000230354.6_Silent_p.Q88Q	NM_003194.4	NP_003185.1	P20226	TBP_HUMAN	TATA box binding protein	88	Poly-Gln.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding	p.Q88Q(1)		breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcagcagcagcagcagcagc	0.612000													4	38					0	0	0.001168	0	0
PTPRB	0	broad.mit.edu	37	12	70925905	70925905	+	Silent	SNP	G	G	A			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr12:70925905G>A	ENST00000334414.6	-	32	6458	c.6414C>T	c.(6412-6414)atC>atT	p.I2138I	PTPRB_ENST00000261266.5_Silent_p.I1920I|PTPRB_ENST00000451516.2_Silent_p.I1830I|RP11-588H23.3_ENST00000549460.1_RNA|RP11-588H23.3_ENST00000548687.1_RNA|PTPRB_ENST00000550857.1_Silent_p.I1830I|PTPRB_ENST00000538708.1_Silent_p.I1830I|RP11-588H23.3_ENST00000547656.1_RNA|PTPRB_ENST00000550358.1_Silent_p.I2050I|RP11-588H23.3_ENST00000546836.1_RNA|RP11-588H23.3_ENST00000551438.1_RNA	NM_001109754.2	NP_001103224.1	P23467	PTPRB_HUMAN	protein tyrosine phosphatase, receptor type, B	1920					angiogenesis	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|central_nervous_system(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(46)|prostate(4)|skin(18)|upper_aerodigestive_tract(1)|urinary_tract(3)	107	Renal(347;0.236)		GBM - Glioblastoma multiforme(2;2.17e-05)|Lung(24;0.000636)|OV - Ovarian serous cystadenocarcinoma(12;0.00306)|STAD - Stomach adenocarcinoma(21;0.149)			ACTGCTGGAGGATTCGGTCCA	0.448000													6	40					0	0	0.001168	0	0
FZD8	8325	broad.mit.edu	37	10	35929635	35929635	+	Silent	SNP	C	C	A			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr10:35929635C>A	ENST00000374694.1	-	1	727	c.723G>T	c.(721-723)gtG>gtT	p.V241V		NM_031866.2	NP_114072.1	Q9H461	FZD8_HUMAN	frizzled family receptor 8	241					axonogenesis|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|T cell differentiation in thymus|vasculature development	cell projection|Golgi apparatus|integral to membrane|plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(3)|prostate(1)|urinary_tract(1)	11						GCTCGCTGGACACGCTCACCA	0.736000													5	40					3.59834e-05	7.19667e-05	0.001168	1	0
MUC16	94025	broad.mit.edu	37	19	9087660	9087660	+	Silent	SNP	G	G	A			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr19:9087660G>A	ENST00000397910.4	-	1	4358	c.4155C>T	c.(4153-4155)acC>acT	p.T1385T		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	1385	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGTCTGTGATGGTCCATGCTT	0.473000													15	128					0	0	0.006122	0	0
OR6C2	341416	broad.mit.edu	37	12	55846662	55846662	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr12:55846662C>A	ENST00000322678.1	+	1	665	c.665C>A	c.(664-666)aCa>aAa	p.T222K	RP11-110A12.2_ENST00000556750.1_RNA|RP11-110A12.2_ENST00000555146.1_RNA|RP11-110A12.2_ENST00000555138.1_RNA|RP11-110A12.2_ENST00000554049.1_RNA	NM_054105.1	NP_473446.1	Q9NZP2	OR6C2_HUMAN	olfactory receptor, family 6, subfamily C, member 2	222					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|large_intestine(5)|lung(8)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	23						ATAGTCAGAACAATTCTGAAG	0.403000													14	145					1.5842e-08	3.23881e-08	0.001855	1	0
NCF4	4689	broad.mit.edu	37	22	37263492	37263492	+	Silent	SNP	C	C	T			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr22:37263492C>T	ENST00000397147.4	+	4	514	c.330C>T	c.(328-330)aaC>aaT	p.N110N	CTA-833B7.2_ENST00000330602.2_RNA|NCF4_ENST00000248899.6_Silent_p.N110N|CTA-833B7.2_ENST00000431290.1_RNA	NM_013416.3	NP_038202.2	Q15080	NCF4_HUMAN	neutrophil cytosolic factor 4, 40kDa	110	PX.				cell communication|immune response|oxidation-reduction process	cytosol|NADPH oxidase complex	phosphatidylinositol binding|protein dimerization activity			cervix(1)|endometrium(4)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	16						CTGCCCTCAACGCCTACATGA	0.577000													4	38					0	0	0.000248	0	0
CYP2D7P1	0	broad.mit.edu	37	22	42538870	42538870	+	RNA	SNP	A	A	C	rs2982057	by1000genomes	TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr22:42538870A>C	ENST00000358097.4	-	0	449				CYP2D7P1_ENST00000433992.1_RNA|CYP2D7P1_ENST00000424775.1_RNA																endometrium(1)	1						CCATAGCGCGACAGGAACACC	0.687000													3	47					0	0	0.001168	0	0
APBB3	10307	broad.mit.edu	37	5	139940031	139940031	+	Missense_Mutation	SNP	A	A	C			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr5:139940031A>C	ENST00000357560.4	-	12	1534	c.1091T>G	c.(1090-1092)tTt>tGt	p.F364C	APBB3_ENST00000412920.3_Missense_Mutation_p.F362C|APBB3_ENST00000358580.5_Missense_Mutation_p.I325M|APBB3_ENST00000356738.2_Missense_Mutation_p.F369C|APBB3_ENST00000511201.2_Missense_Mutation_p.I323M|APBB3_ENST00000354402.5_Missense_Mutation_p.F371C|APBB3_ENST00000508496.2_Missense_Mutation_p.F141C	NM_006051.3|NM_133173.2	NP_006042.3|NP_573419.2	O95704	APBB3_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 3	364	PID 2.					actin cytoskeleton|cytoplasm				endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|prostate(1)	11			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AACACCAATAAATGTCACAAG	0.632000													4	41					0	0	0.000248	0	0
PDGFB	5155	broad.mit.edu	37	22	39626111	39626111	+	Silent	SNP	C	C	T	rs149693918		TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr22:39626111C>T	ENST00000331163.6	-	5	1366	c.579G>A	c.(577-579)ccG>ccA	p.P193P	PDGFB_ENST00000381551.4_Silent_p.P178P	NM_002608.2	NP_002599.1	P01127	PDGFB_HUMAN	platelet-derived growth factor beta polypeptide	193					activation of protein kinase B activity|cellular response to mycophenolic acid|embryonic placenta development|heart development|hemopoiesis|metanephric glomerular mesangial cell development|monocyte chemotaxis|negative regulation of phosphatidylinositol biosynthetic process|negative regulation of platelet activation|negative regulation of transcription, DNA-dependent|paracrine signaling|peptidyl-serine phosphorylation|peptidyl-tyrosine phosphorylation|platelet activation|platelet degranulation|positive regulation of blood vessel endothelial cell migration|positive regulation of calcium ion import|positive regulation of cell division|positive regulation of chemotaxis|positive regulation of cyclin-dependent protein kinase activity|positive regulation of DNA biosynthetic process|positive regulation of DNA replication|positive regulation of endothelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of fibroblast proliferation|positive regulation of glomerular filtration|positive regulation of glomerular mesangial cell proliferation|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein autophosphorylation|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|positive regulation of transcription, DNA-dependent|reactive oxygen species metabolic process|transforming growth factor beta receptor signaling pathway	basolateral plasma membrane|cell surface|endoplasmic reticulum lumen|extracellular region|Golgi membrane|platelet alpha granule lumen	collagen binding|eukaryotic cell surface binding|growth factor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein heterodimerization activity|protein homodimerization activity|superoxide-generating NADPH oxidase activator activity		COL1A1/PDGFB(429)	central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(2)	7	Melanoma(58;0.04)				Becaplermin(DB00102)	GGGAACCCCCCGGGCTTCGGG	0.622000			T	COL1A1	DFSP								11	109					0	0	0.000978	0	0
KIF21A	55605	broad.mit.edu	37	12	39696874	39696874	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr12:39696874G>A	ENST00000395670.3	-	35	5046	c.4627C>T	c.(4627-4629)Cat>Tat	p.H1543Y	KIF21A_ENST00000361961.3_Missense_Mutation_p.H1529Y|KIF21A_ENST00000361418.5_Missense_Mutation_p.H1542Y|KIF21A_ENST00000544797.2_Missense_Mutation_p.H1505Y|KIF21A_ENST00000541463.2_Missense_Mutation_p.H1489Y			Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	1542					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|lung(41)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(1)|urinary_tract(2)	86		Lung NSC(34;0.179)|all_lung(34;0.213)				CCATCATAATGAGGGGGTTCA	0.393000													10	85					0	0	0.008291	0	0
AMZ1	155185	broad.mit.edu	37	7	2748832	2748832	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr7:2748832G>A	ENST00000312371.4	+	5	1093	c.725G>A	c.(724-726)gGc>gAc	p.G242D	AMZ1_ENST00000407112.1_Intron|AMZ1_ENST00000489665.1_Intron	NM_133463.1	NP_597720.1	Q400G9	AMZ1_HUMAN	archaelysin family metallopeptidase 1	242							metallopeptidase activity|zinc ion binding			breast(2)|kidney(1)|large_intestine(4)|lung(8)|skin(1)	16		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;5.03e-14)		CAGGACAGGGGCTGGGCCCTG	0.687000													5	35					0	0	0.001168	0	0
ZNF208	7757	broad.mit.edu	37	19	22156520	22156520	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr19:22156520T>C	ENST00000397126.4	-	4	1464	c.1316A>G	c.(1315-1317)aAc>aGc	p.N439S	ZNF208_ENST00000599916.1_Intron|ZNF208_ENST00000601773.1_Intron	NM_007153.3	NP_009084.2			zinc finger protein 208											breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(18)|liver(1)|lung(71)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	113		all_lung(12;0.0961)|Lung NSC(12;0.103)				TTCCATAAGGTTTGAGGACCA	0.373000													7	67					0	0	0.001984	0	0
MYH4	4622	broad.mit.edu	37	17	10366430	10366430	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr17:10366430G>A	ENST00000255381.2	-	10	991	c.881C>T	c.(880-882)tCc>tTc	p.S294F	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_017533.2	NP_060003.2	Q9Y623	MYH4_HUMAN	myosin, heavy chain 4, skeletal muscle	294	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			NS(4)|breast(8)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(72)|ovary(10)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(3)	149						TTTCTTATTGGACAGGATTTG	0.368000													6	58					0	0	0.003080	0	0
ZNF426	79088	broad.mit.edu	37	19	9640096	9640096	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr19:9640096T>C	ENST00000593003.1	-	6	988	c.511A>G	c.(511-513)Aca>Gca	p.T171A	ZNF426_ENST00000589289.1_3'UTR|ZNF426_ENST00000535489.1_Missense_Mutation_p.T209A|ZNF426_ENST00000253115.2_Missense_Mutation_p.T209A			Q9BUY5	ZN426_HUMAN	zinc finger protein 426	209					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(3)|ovary(1)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	20						ATATTTGGTGTCAGGCTGAAG	0.373000													4	121					0	0	0.000248	0	0
NRXN1	9378	broad.mit.edu	37	2	50850692	50850692	+	Silent	SNP	T	T	C			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr2:50850692T>C	ENST00000404971.1	-	7	2332	c.993A>G	c.(991-993)caA>caG	p.Q331Q	NRXN1_ENST00000402717.3_Silent_p.Q298Q|NRXN1_ENST00000406316.2_Silent_p.Q298Q|NRXN1_ENST00000405472.3_Silent_p.Q298Q|NRXN1_ENST00000331040.5_5'UTR|NRXN1_ENST00000406859.3_Silent_p.Q298Q|NRXN1_ENST00000401669.2_Silent_p.Q298Q	NM_001135659.1	NP_001129131.1	Q9ULB1	NRX1A_HUMAN	neurexin 1	298	Laminin G-like 2.				adult behavior|axon guidance|cell adhesion|grooming behavior|learning|neuromuscular process controlling balance|positive regulation of excitatory postsynaptic membrane potential|prepulse inhibition	cell surface|integral to plasma membrane	metal ion binding|protein binding|receptor activity			breast(1)|endometrium(3)|kidney(3)|large_intestine(10)|lung(33)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	58		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			GAATGGGGTTTTGAGACAAGT	0.378000													7	105					0	0	0.003080	0	0
ADH1C	126	broad.mit.edu	37	4	100273819	100273819	+	RNA	SNP	C	C	T			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr4:100273819C>T	ENST00000515683.1	-	0	365				ADH1C_ENST00000510055.1_RNA	NM_000669.3	NP_000660.1	P00326	ADH1G_HUMAN	alcohol dehydrogenase 1C (class I), gamma polypeptide						ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|zinc ion binding								OV - Ovarian serous cystadenocarcinoma(123;1.08e-07)	Fomepizole(DB01213)|NADH(DB00157)	GCTTACTTTTCCTGCTGTGCT	0.313000													12	86					0	0	0.001368	0	0
SPRED2	200734	broad.mit.edu	37	2	65540895	65540895	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr2:65540895C>T	ENST00000356388.4	-	6	1186	c.997G>A	c.(997-999)Gtg>Atg	p.V333M	SPRED2_ENST00000443619.2_Missense_Mutation_p.V330M	NM_181784.2	NP_861449.2	Q7Z698	SPRE2_HUMAN	sprouty-related, EVH1 domain containing 2	333	SPR.				inactivation of MAPK activity|multicellular organismal development	transport vesicle membrane	stem cell factor receptor binding			breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(11)|lung(7)|ovary(2)|upper_aerodigestive_tract(3)	34						CAAGTTCTCACGGAGTCGGGC	0.637000													6	157					0	0	0.001168	0	0
MYO9B	4650	broad.mit.edu	37	19	17265124	17265124	+	Splice_Site	SNP	G	G	A			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr19:17265124G>A	ENST00000595618.1	+	6	1250		c.e6-1		CTD-3032J10.2_ENST00000597216.1_RNA|CTD-3032J10.2_ENST00000599360.1_RNA|MYO9B_ENST00000397274.2_Splice_Site|MYO9B_ENST00000594824.1_Splice_Site	NM_001130065.1|NM_004145.3	NP_001123537.1|NP_004136.2	Q13459	MYO9B_HUMAN	myosin IXB						actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(3)|endometrium(9)|kidney(2)|large_intestine(1)|lung(19)|soft_tissue(1)|urinary_tract(4)	39						TTGTTTTCCAGCATAACTTGA	0.587000													3	57					0	0	0.004672	0	0
CCDC41	51134	broad.mit.edu	37	12	94763798	94763798	+	Silent	SNP	T	T	C			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr12:94763798T>C	ENST00000397809.5	-	9	1497	c.948A>G	c.(946-948)aaA>aaG	p.K316K	CCDC41_ENST00000397807.2_Silent_p.K283K|CCDC41_ENST00000547575.1_Silent_p.K316K|CCDC41_ENST00000549352.1_5'UTR|CCDC41_ENST00000339839.5_Silent_p.K316K	NM_016122.2	NP_057206.2	Q9Y592	CCD41_HUMAN	coiled-coil domain containing 41	308										breast(1)|central_nervous_system(3)|kidney(3)|large_intestine(8)|lung(8)|prostate(2)|skin(2)	27						TGTTTGAATGTTTAAGTTCTT	0.328000													5	153					0	0	0.001168	0	0
CTC-338M12.9	0	broad.mit.edu	37	5	180708698	180708699	+	RNA	INS	-	-	G	rs1815381		TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr5:180708698_180708699insG	ENST00000412295.2	+	0	238																											gggcggtaggcgggggctggag	0.723													3	6	---	---	---	---					
TOPORS	10210	broad.mit.edu	37	9	32544153	32544154	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr9:32544153_32544154delAG	ENST00000360538.2	-	3	485_486	c.369_370delCT	c.(367-372)ttgtfs	p.FC123fs	TOPORS_ENST00000379858.1_Frame_Shift_Del_p.FC58fs	NM_005802.4	NP_005793.2	Q9NS56	TOPRS_HUMAN	topoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase	123	E3 ubiquitin-protein ligase activity.|Required for DNA-binding.				DNA damage response, signal transduction resulting in induction of apoptosis|maintenance of protein location in nucleus|proteasomal ubiquitin-dependent protein catabolic process|protein sumoylation|transcription, DNA-dependent	nuclear speck|PML body	antigen binding|DNA binding|DNA topoisomerase I binding|SUMO ligase activity|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(6)|ovary(3)|skin(2)|upper_aerodigestive_tract(1)	12			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.0018)		CAGCGAAAACAGAACTTATGTA	0.401													20	115	---	---	---	---					
POLI	11201	broad.mit.edu	37	18	51795958	51795960	+	In_Frame_Del	DEL	CGA	CGA	-	rs140689079		TCGA-G9-6343-01A-21D-1961-08	TCGA-G9-6343-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdb78cfc-4a29-488a-b215-a4996b3ab873	e4bf7fcc-99b3-4e83-8336-2caacc77a011	g.chr18:51795958_51795960delCGA	ENST00000579534.1	+	1	185_187	c.42_44delCGA	c.(40-45)ggc>gg	p.GD14del	POLI_ENST00000579434.1_5'UTR|POLI_ENST00000406285.3_In_Frame_Del_p.GD14del	NM_007195.2	NP_009126.2	Q9UNA4	POLI_HUMAN	polymerase (DNA directed) iota	14					DNA repair|DNA replication	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding|protein binding	p.D17delD(1)		breast(1)|endometrium(4)|kidney(2)|large_intestine(10)|lung(5)|ovary(3)|urinary_tract(1)	26				Colorectal(16;0.0234)|READ - Rectum adenocarcinoma(59;0.197)		AAGGCGGCGGCGACGACGACGAG	0.729								DNA polymerases (catalytic subunits)					5	4	---	---	---	---					
