Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SRCRB4D	136853	broad.mit.edu	37	7	76029805	76029805	+	Silent	SNP	G	G	A			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr7:76029805G>A	ENST00000275560.3	-	4	620	c.273C>T	c.(271-273)gaC>gaT	p.D91D	ZP3_ENST00000336517.4_Intron	NM_080744.1	NP_542782.1	Q8WTU2	SRB4D_HUMAN	scavenger receptor cysteine rich domain containing, group B (4 domains)	91	SRCR 1.					extracellular region|membrane	scavenger receptor activity	p.D91D(1)		autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(9)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	21						CTACGTTGGCGTCCACCACGT	0.701000													6	7					0	0	0.001984	0	0
BAI1	575	broad.mit.edu	37	8	143603449	143603449	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr8:143603449C>T	ENST00000517894.1	+	21	4042	c.3148C>T	c.(3148-3150)Cgc>Tgc	p.R1050C	BAI1_ENST00000323289.5_Missense_Mutation_p.R1050C			O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	1050					axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding	p.R1050C(1)		NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(28)|ovary(4)|pancreas(1)|prostate(7)	57	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					CCGCCTCATCCGCAAGCGCTT	0.652000													10	30					0	0	0.010729	0	0
TET1	80312	broad.mit.edu	37	10	70446226	70446226	+	Silent	SNP	G	G	A			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr10:70446226G>A	ENST00000373644.4	+	11	5375	c.5166G>A	c.(5164-5166)aaG>aaA	p.K1722K		NM_030625.2	NP_085128.2	Q8NFU7	TET1_HUMAN	tet methylcytosine dioxygenase 1	1722					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding	p.K1722K(1)		breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(2)|ovary(5)|prostate(1)|upper_aerodigestive_tract(2)	21						TTGGCTCCAAGGAAGGAATGG	0.498000													51	75					0	0	0.014410	0	0
NBPF9	400818	broad.mit.edu	37	1	144828704	144828704	+	Missense_Mutation	SNP	T	T	G			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr1:144828704T>G	ENST00000338347.4	+	14	1750	c.1750T>G	c.(1750-1752)Tac>Gac	p.Y584D	NBPF9_ENST00000440491.2_3'UTR|NBPF9_ENST00000468645.1_3'UTR|NBPF9_ENST00000281815.8_Missense_Mutation_p.Y182D					neuroblastoma breakpoint family, member 9									p.L657L(3)|p.Y584D(1)		NS(2)|prostate(1)	3						CTTCGCCCTTTACGTGGACAA	0.438000													6	288					0	0	0.001984	0	0
DGKQ	1609	broad.mit.edu	37	4	956320	956320	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr4:956320T>C	ENST00000273814.3	-	18	2190	c.2117A>G	c.(2116-2118)gAg>gGg	p.E706G		NM_001347.3	NP_001338.2	P52824	DGKQ_HUMAN	diacylglycerol kinase, theta 110kDa	706	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|platelet activation|protein kinase C signaling cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to ATP|thrombin receptor signaling pathway	cytoskeleton|cytosol|nuclear speck|plasma membrane	activating transcription factor binding|ATP binding|diacylglycerol kinase activity|kinase binding|metal ion binding|phospholipase binding	p.E706G(1)		breast(1)|endometrium(2)|kidney(2)|lung(2)|prostate(2)	9			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			GGCGTCGGCCTCGTCCACAGA	0.657000													8	22					0	0	0.004482	0	0
CTTNBP2	83992	broad.mit.edu	37	7	117386131	117386131	+	Missense_Mutation	SNP	A	A	T			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr7:117386131A>T	ENST00000160373.3	-	13	3462	c.3371T>A	c.(3370-3372)aTt>aAt	p.I1124N		NM_033427.2	NP_219499.1	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	1124								p.I1124N(1)		breast(3)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(36)|ovary(4)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		GCCGTGGAAAATGACATTATG	0.398000											OREG0003442	type=REGULATORY REGION|Gene=CTTNBP2|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	24	47					0	0	0.018920	0	0
MEGF10	84466	broad.mit.edu	37	5	126771182	126771182	+	Splice_Site	SNP	G	G	C			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr5:126771182G>C	ENST00000274473.6	+	17	2371		c.e17+1		MEGF10_ENST00000503335.2_Splice_Site	NM_032446.2	NP_115822.1	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10						cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup		p.?(1)		breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(28)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	68		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		TGCTCTCAACGTAAGTCTTGT	0.373000													15	17					0	0	0.002450	0	0
IGHG1	0	broad.mit.edu	37	14	106208715	106208715	+	RNA	SNP	T	T	G			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr14:106208715T>G	ENST00000390548.2	-	0	302																											TGTCACAAGATTTGGGCTCTG	0.582000													91	130					0	0	0.014410	0	0
HSPA6	3310	broad.mit.edu	37	1	161494903	161494903	+	Missense_Mutation	SNP	T	T	G			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr1:161494903T>G	ENST00000309758.4	+	1	868	c.455T>G	c.(454-456)tTc>tGc	p.F152C		NM_002155.3	NP_002146.2	P17066	HSP76_HUMAN	heat shock 70kDa protein 6 (HSP70B')	152					response to unfolded protein		ATP binding	p.F152C(2)		endometrium(3)|large_intestine(5)|lung(9)|prostate(2)|skin(2)	21	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			CCCGCCTATTTCAATGACTCG	0.632000													17	44					0	0	0.006122	0	0
SLC45A4	57210	broad.mit.edu	37	8	142222492	142222492	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr8:142222492C>T	ENST00000519067.1	-	7	2255	c.1952G>A	c.(1951-1953)gGc>gAc	p.G651D	SLC45A4_ENST00000517878.1_Missense_Mutation_p.G702D|SLC45A4_ENST00000433583.2_Missense_Mutation_p.G644D|SLC45A4_ENST00000024061.3_Missense_Mutation_p.G651D			Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	702					transport	integral to membrane		p.G651D(1)		breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			CAGGAAAGAGCCCACAGAGGC	0.627000													18	37					0	0	0.010504	0	0
PRSS58	136541	broad.mit.edu	37	7	141952406	141952406	+	Silent	SNP	A	A	C			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr7:141952406A>C	ENST00000552471.1	-	4	781	c.462T>G	c.(460-462)acT>acG	p.T154T	PRSS58_ENST00000547058.2_Silent_p.T154T			Q8IYP2	PRS58_HUMAN	protease, serine, 58	154	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity	p.T154T(2)		kidney(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(2)|skin(2)	19						AGATGTTCACAGTTTGCAGTG	0.383000													9	229					0	0	0.006214	0	0
LPPR5	0	broad.mit.edu	37	1	99422183	99422183	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr1:99422183G>A	ENST00000370188.3	-	2	712	c.352C>T	c.(352-354)Cga>Tga	p.R118*	LPPR5_ENST00000263177.4_Nonsense_Mutation_p.R118*	NM_001010861.2	NP_001010861.1	Q32ZL2	LPPR5_HUMAN		118						integral to membrane	hydrolase activity	p.R118*(1)									CGGACAGTTCGGCGCACCAGC	0.358000													25	28					0	0	0.018920	0	0
ABCB1	5243	broad.mit.edu	37	7	87138593	87138593	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr7:87138593T>C	ENST00000265724.3	-	27	3904	c.3487A>G	c.(3487-3489)Aat>Gat	p.N1163D	ABCB1_ENST00000543898.1_Missense_Mutation_p.N1099D|ABCB1_ENST00000488737.2_5'UTR	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	1163	ABC transporter 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity	p.N1163D(1)		NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	AGACTTACATTAGGCAGTGAC	0.493000													23	178					0	0	0.014323	0	0
SIRPB1	10326	broad.mit.edu	37	20	1600530	1600530	+	Silent	SNP	G	G	A			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr20:1600530G>A	ENST00000381605.4	-	1	125	c.61C>T	c.(61-63)Ctg>Ttg	p.L21L	SIRPB1_ENST00000381603.3_Silent_p.L21L|RP4-576H24.4_ENST00000564763.1_Silent_p.L21L|SIRPB1_ENST00000279477.7_Silent_p.L21L|SIRPB1_ENST00000381596.1_5'UTR|SIRPB1_ENST00000568365.1_Silent_p.L21L	NM_006065.3	NP_006056.2	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1	21					cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding	p.L21L(1)		central_nervous_system(2)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	31						AGTCTCCCCAGCAGTAGCGTC	0.562000													28	41					0	0	0.007291	0	0
C1orf192	257177	broad.mit.edu	37	1	161334829	161334829	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr1:161334829A>G	ENST00000367974.1	-	5	465	c.460T>C	c.(460-462)Tcc>Ccc	p.S154P		NM_001013625.2	NP_001013647.2	Q5VTH2	CA192_HUMAN	chromosome 1 open reading frame 192	154								p.S154P(1)		endometrium(1)|large_intestine(3)|lung(5)|prostate(1)	10	all_cancers(52;4.64e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			TCATCTGGGGAATTGAGGTTG	0.498000													35	70					0	0	0.013726	0	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803543	142803543	+	RNA	SNP	C	C	T			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr1:142803543C>T	ENST00000423385.1	-	0	1422																											TGTTGGAATTCCTGATGAATC	0.269000													6	190					0	0	0.001168	0	0
TGOLN2	10618	broad.mit.edu	37	2	85553644	85553644	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr2:85553644T>C	ENST00000377386.3	-	2	1673	c.1211A>G	c.(1210-1212)cAc>cGc	p.H404R	TGOLN2_ENST00000444342.2_Missense_Mutation_p.H404R|TGOLN2_ENST00000409232.3_Missense_Mutation_p.H404R|TGOLN2_ENST00000409015.1_Missense_Mutation_p.H404R|TGOLN2_ENST00000398263.2_Missense_Mutation_p.H346R|TGOLN2_ENST00000282120.2_Missense_Mutation_p.H248R			O43493	TGON2_HUMAN	trans-golgi network protein 2	404						integral to membrane|nucleus|plasma membrane|trans-Golgi network|transport vesicle	protein binding	p.H404R(1)									CCGCTTGTTGTGATGAGCGAT	0.562000													26	41					0	0	0.005443	0	0
EFCAB14	9813	broad.mit.edu	37	1	47149017	47149017	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr1:47149017C>T	ENST00000371933.3	-	10	2243	c.1267G>A	c.(1267-1269)Gcc>Acc	p.A423T	EFCAB14-AS1_ENST00000442839.1_RNA|EFCAB14_ENST00000544071.1_Missense_Mutation_p.A359T|EFCAB14-AS1_ENST00000418985.1_RNA	NM_014774.2	NP_055589.1			EF-hand calcium binding domain 14									p.A423T(1)									CTTAGTTGGGCAGCTTTCTCA	0.388000													33	60					0	0	0.013726	0	0
ZZEF1	23140	broad.mit.edu	37	17	3980274	3980274	+	Missense_Mutation	SNP	T	T	G			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr17:3980274T>G	ENST00000381638.2	-	20	3123	c.2999A>C	c.(2998-3000)cAg>cCg	p.Q1000P	ZZEF1_ENST00000574474.1_5'UTR	NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	1000							calcium ion binding|zinc ion binding	p.Q1000P(1)		central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						TGCCAGAAACTGGCCCACATC	0.363000													18	40					0	0	0.004990	0	0
TWF1	5756	broad.mit.edu	37	12	44189532	44189532	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr12:44189532C>A	ENST00000395510.2	-	9	1038	c.909G>T	c.(907-909)ttG>ttT	p.L303F	TWF1_ENST00000552521.1_Missense_Mutation_p.L205F|TWF1_ENST00000548315.1_Missense_Mutation_p.L310F|TWF1_ENST00000325127.4_Missense_Mutation_p.L337F	NM_001242397.1|NM_002822.4	NP_001229326.1|NP_002813.3	Q12792	TWF1_HUMAN	twinfilin actin-binding protein 1	303	ADF-H 2.					actin cytoskeleton|cytoplasm	actin binding|protein tyrosine kinase activity	p.L303F(1)		endometrium(2)|large_intestine(6)|lung(4)|prostate(1)|stomach(1)	14	all_cancers(12;0.00125)	Lung NSC(34;0.0804)|all_lung(34;0.181)		GBM - Glioblastoma multiforme(48;0.0474)		AGTCTGCAGTCAACTCATCCC	0.383000													38	59					8.69298e-16	1.00656e-15	0.006999	1	0
MAP3K10	4294	broad.mit.edu	37	19	40698519	40698519	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr19:40698519A>G	ENST00000253055.3	+	1	869	c.581A>G	c.(580-582)cAc>cGc	p.H194R	MAP3K10_ENST00000593906.1_Intron	NM_002446.3	NP_002437.2	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase 10	194	Protein kinase.				activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity	p.H194R(2)		NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	24						GTGCCACCTCACGTGCTGGTC	0.642000													10	17					0	0	0.010729	0	0
IGKV2-24	0	broad.mit.edu	37	2	89475970	89475970	+	RNA	SNP	G	G	C			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr2:89475970G>C	ENST00000484817.1	-	0	231																											AGTCTTGGAGGCTGGCCTGGC	0.522000													6	213					0	0	0.001168	0	0
FBLN2	2199	broad.mit.edu	37	3	13663379	13663379	+	Missense_Mutation	SNP	G	G	T			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr3:13663379G>T	ENST00000404922.3	+	9	2379	c.2260G>T	c.(2260-2262)Gat>Tat	p.D754Y	FBLN2_ENST00000492059.1_Missense_Mutation_p.D754Y|FBLN2_ENST00000535798.1_Intron|FBLN2_ENST00000295760.7_Intron	NM_001004019.1	NP_001004019.1	P98095	FBLN2_HUMAN	fibulin 2	753	EGF-like 3; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent	p.D754Y(1)|p.D173Y(1)		haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(3)|prostate(3)|urinary_tract(1)	24			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			GCTCTGTGCCGATGGCTATAT	0.612000													11	27					3.07112e-06	3.43549e-06	0.010729	1	0
LAMA4	3910	broad.mit.edu	37	6	112441551	112441551	+	Missense_Mutation	SNP	T	T	G			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr6:112441551T>G	ENST00000230538.7	-	33	4997	c.4600A>C	c.(4600-4602)Aat>Cat	p.N1534H	LAMA4_ENST00000522006.1_Missense_Mutation_p.N1527H|LAMA4_ENST00000389463.4_Missense_Mutation_p.N1527H|LAMA4_ENST00000424408.2_Missense_Mutation_p.N1527H	NM_001105206.2	NP_001098676.2	Q16363	LAMA4_HUMAN	laminin, alpha 4	1534	Laminin G-like 4.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding	p.N1527H(1)		NS(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(42)|ovary(4)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(8)	100		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		TGACCAACATTAAACATGTAA	0.418000													20	16					0	0	0.008871	0	0
ATRX	546	broad.mit.edu	37	X	76891438	76891438	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chrX:76891438A>G	ENST00000373344.5	-	16	4881	c.4667T>C	c.(4666-4668)aTg>aCg	p.M1556T	ATRX_ENST00000395603.3_Missense_Mutation_p.M1518T|ATRX_ENST00000480283.1_5'UTR	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	1556					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.M1556T(2)|p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	TTTGATAACCATATTTCTATG	0.338000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						18	5					0	0	0.004990	0	0
IFT122	55764	broad.mit.edu	37	3	129188218	129188218	+	Missense_Mutation	SNP	C	C	G			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr3:129188218C>G	ENST00000296266.3	+	10	1119	c.927C>G	c.(925-927)gaC>gaG	p.D309E	IFT122_ENST00000440957.2_Missense_Mutation_p.D49E|IFT122_ENST00000431818.2_Missense_Mutation_p.D108E|IFT122_ENST00000349441.2_Missense_Mutation_p.D147E|IFT122_ENST00000348417.2_Missense_Mutation_p.D258E|IFT122_ENST00000347300.2_Missense_Mutation_p.D199E|IFT122_ENST00000507564.1_Missense_Mutation_p.D250E|IFT122_ENST00000504021.1_Missense_Mutation_p.D152E	NM_052985.2	NP_443711.2	Q9HBG6	IF122_HUMAN	intraflagellar transport 122 homolog (Chlamydomonas)	258					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium		p.D309E(1)		breast(3)|cervix(1)|endometrium(9)|large_intestine(10)|lung(21)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	52						CTGTGGCTGACTGGGGACAGA	0.443000													63	79					0	0	0.014410	0	0
MKI67	4288	broad.mit.edu	37	10	129901213	129901213	+	Missense_Mutation	SNP	C	C	G			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr10:129901213C>G	ENST00000368654.3	-	13	9266	c.8891G>C	c.(8890-8892)cGg>cCg	p.R2964P	MKI67_ENST00000368653.3_Missense_Mutation_p.R2604P	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	2964					cell proliferation	nucleolus	ATP binding|protein C-terminus binding	p.R2964P(1)		NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TTTAGGGGCCCGAAGAACTCT	0.493000													58	133					0	0	0.014410	0	0
SPAG16	79582	broad.mit.edu	37	2	214794778	214794778	+	Missense_Mutation	SNP	C	C	T	rs142357329	byFrequency	TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr2:214794778C>T	ENST00000331683.5	+	12	1404	c.1309C>T	c.(1309-1311)Cgc>Tgc	p.R437C	SPAG16_ENST00000374309.3_Missense_Mutation_p.R343C	NM_024532.4	NP_078808.3	Q8N0X2	SPG16_HUMAN	sperm associated antigen 16	437					cilium assembly	cilium axoneme|flagellar axoneme		p.R437C(2)		endometrium(4)|kidney(1)|large_intestine(15)|lung(27)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	56		Renal(323;0.00461)		UCEC - Uterine corpus endometrioid carcinoma (47;0.0525)|Epithelial(149;7.07e-07)|all cancers(144;7.96e-05)|Lung(261;0.00255)|LUSC - Lung squamous cell carcinoma(224;0.00599)		AGGACACAGCCGCGCAGTGTG	0.438000													49	50					0	0	0.014410	0	0
TPTE2	93492	broad.mit.edu	37	13	20049751	20049751	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr13:20049751C>A	ENST00000400230.2	-	5	236	c.192G>T	c.(190-192)aaG>aaT	p.K64N	TPTE2_ENST00000382978.1_Missense_Mutation_p.K64N|TPTE2_ENST00000255310.6_Intron|TPTE2_ENST00000457266.2_Intron|TPTE2_ENST00000382977.4_Missense_Mutation_p.K64N|TPTE2_ENST00000390680.2_Intron|TPTE2_ENST00000382975.4_Missense_Mutation_p.K64N|TPTE2_ENST00000400103.2_Intron			Q6XPS3	TPTE2_HUMAN	transmembrane phosphoinositide 3-phosphatase and tensin homolog 2	64						endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.K64N(1)		NS(2)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(8)|lung(21)|pancreas(1)|prostate(8)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		GCACAATTTTCTTAATCTTGC	0.299000													20	33					2.27731e-05	2.50504e-05	0.012319	1	0
C19orf47	126526	broad.mit.edu	37	19	40832339	40832339	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr19:40832339C>T	ENST00000582783.1	-	7	617	c.605G>A	c.(604-606)cGg>cAg	p.R202Q	C19orf47_ENST00000392035.2_Missense_Mutation_p.R135Q	NM_001256440.1	NP_001243369.1	Q8N9M1	CS047_HUMAN	chromosome 19 open reading frame 47	202								p.R135Q(1)		endometrium(5)|kidney(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	20			Lung(22;0.000636)			AGCAGTGACCCGGCGCCGCTT	0.627000													11	26					0	0	0.010729	0	0
PRSS50	29122	broad.mit.edu	37	3	46759103	46759103	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr3:46759103G>A	ENST00000460241.1	-	7	1801	c.131C>T	c.(130-132)cCg>cTg	p.P44L	PRSS50_ENST00000315170.7_Missense_Mutation_p.P44L			Q9UI38	TSP50_HUMAN	protease, serine, 50	44					proteolysis	endoplasmic reticulum	serine-type endopeptidase activity|threonine-type endopeptidase activity	p.P44L(1)		endometrium(2)|kidney(2)|large_intestine(1)|lung(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	11						CAGCGCCCCCGGGGCTTCCCC	0.706000													12	17					0	0	0.010729	0	0
ACAP1	9744	broad.mit.edu	37	17	7250419	7250419	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr17:7250419C>T	ENST00000158762.3	+	14	1407	c.1201C>T	c.(1201-1203)Cct>Tct	p.P401S		NM_014716.3	NP_055531.1	Q15027	ACAP1_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	401					intracellular signal transduction|lipid metabolic process|protein transport|regulation of ARF GTPase activity		ARF GTPase activator activity|phospholipase C activity|protein binding|zinc ion binding	p.P401S(1)		NS(1)|breast(5)|cervix(3)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(6)|prostate(3)|skin(1)|urinary_tract(1)	33						GGGAAGGGAGCCTGGGGGAGT	0.677000													7	40					0	0	0.001984	0	0
XIST	0	broad.mit.edu	37	X	73066388	73066388	+	RNA	SNP	G	G	T			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chrX:73066388G>T	ENST00000429829.1	-	0	6200					NR_001564.2																						AATGAGCAGTGTGCGATTACG	0.463000													63	15					2.01871e-26	2.3792e-26	0.014410	1	0
SLC27A4	10999	broad.mit.edu	37	9	131107632	131107632	+	Silent	SNP	C	C	G			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr9:131107632C>G	ENST00000300456.3	+	3	477	c.360C>G	c.(358-360)gcC>gcG	p.A120A	SLC27A4_ENST00000372870.1_Intron	NM_005094.3	NP_005085.2	Q6P1M0	S27A4_HUMAN	solute carrier family 27 (fatty acid transporter), member 4	120					long-chain fatty acid transport|transmembrane transport	integral to membrane	fatty acid transporter activity|nucleotide binding|protein binding	p.A120A(1)		autonomic_ganglia(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(2)	13						TCCTGCAGGCCCGGGGCCTGG	0.622000													16	29					0	0	0.004007	0	0
NID1	4811	broad.mit.edu	37	1	236156998	236156998	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr1:236156998C>T	ENST00000264187.6	-	13	2784	c.2702G>A	c.(2701-2703)cGc>cAc	p.R901H	NID1_ENST00000366595.3_Missense_Mutation_p.R768H	NM_002508.2	NP_002499.2	P14543	NID1_HUMAN	nidogen 1	901	Thyroglobulin type-1.				cell-matrix adhesion	basement membrane	calcium ion binding	p.R901H(1)		breast(4)|endometrium(9)|kidney(1)|large_intestine(23)|lung(20)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(1)	66	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	GCGGCCGTCGCGATCCACGCA	0.697000													5	12					0	0	0.001168	0	0
ADH1B	125	broad.mit.edu	37	4	100237249	100237249	+	Missense_Mutation	SNP	G	G	T			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr4:100237249G>T	ENST00000305046.8	-	5	440	c.373C>A	c.(373-375)Cag>Aag	p.Q125K	ADH1B_ENST00000394887.3_Missense_Mutation_p.Q85K			P00325	ADH1B_HUMAN	alcohol dehydrogenase 1B (class I), beta polypeptide	125					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|zinc ion binding	p.Q125K(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	33				OV - Ovarian serous cystadenocarcinoma(123;1.02e-07)	Fomepizole(DB01213)|NADH(DB00157)	GTGCCATCCTGCAGGGTCCCC	0.547000													20	33					6.33239e-15	7.20582e-15	0.010504	1	0
CUX1	1523	broad.mit.edu	37	7	101845118	101845118	+	Silent	SNP	C	C	T			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr7:101845118C>T	ENST00000360264.3	+	18	2594	c.2574C>T	c.(2572-2574)ggC>ggT	p.G858G	CUX1_ENST00000560541.1_Intron|CUX1_ENST00000556210.1_Silent_p.G689G|CUX1_ENST00000550008.2_Silent_p.G791G|CUX1_ENST00000549414.2_Silent_p.G825G|CUX1_ENST00000547394.2_Intron|CUX1_ENST00000546411.2_Silent_p.G745G|CUX1_ENST00000437600.4_Intron|CUX1_ENST00000292535.7_Silent_p.G847G|CUX1_ENST00000292538.4_Intron|CUX1_ENST00000425244.2_Intron|CUX1_ENST00000393824.3_Intron	NM_001202543.1	NP_001189472.1	P39880	CUX1_HUMAN	cut-like homeobox 1	847					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.G847G(1)		breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						AAGAAACGGGCGGCGGGAAAG	0.687000													5	75					0	0	0.014758	0	0
MUC16	94025	broad.mit.edu	37	19	9061392	9061392	+	Missense_Mutation	SNP	G	G	C			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr19:9061392G>C	ENST00000397910.4	-	3	26257	c.26054C>G	c.(26053-26055)aCa>aGa	p.T8685R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8687	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.T8685R(2)|p.T4318R(1)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGAAACACTTGTATTCCCCAG	0.458000													35	45					0	0	0.017118	0	0
CPS1	1373	broad.mit.edu	37	2	211541794	211541794	+	Silent	SNP	C	C	T			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr2:211541794C>T	ENST00000233072.5	+	37	4534	c.4338C>T	c.(4336-4338)gtC>gtT	p.V1446V	CPS1_ENST00000430249.2_Silent_p.V1452V|CPS1_ENST00000451903.2_Silent_p.V995V	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	1446					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity	p.V1446V(1)		breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		CTAAATTTGTCCATGATAATT	0.378000													48	89					0	0	0.014410	0	0
MYLK	4638	broad.mit.edu	37	3	123451902	123451902	+	Missense_Mutation	SNP	G	G	C			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr3:123451902G>C	ENST00000360772.3	-	12	1735	c.1357C>G	c.(1357-1359)Ccc>Gcc	p.P453A	MYLK_ENST00000360304.3_Missense_Mutation_p.P453A|MYLK_ENST00000359169.1_Missense_Mutation_p.P453A|MYLK_ENST00000346322.5_Intron|MYLK_ENST00000475616.1_Missense_Mutation_p.P453A			Q15746	MYLK_HUMAN	myosin light chain kinase	453	Ig-like C2-type 3.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity	p.P453A(2)		NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		CTCCTCACGGGGGTGCCTTCC	0.572000													6	26					0	0	0.001984	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96521777	96521777	+	Missense_Mutation	SNP	T	T	C	rs77768218		TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr2:96521777T>C	ENST00000456556.1	-	63	4316	c.4232A>G	c.(4231-4233)cAt>cGt	p.H1411R	ANKRD36C_ENST00000420871.2_Missense_Mutation_p.H662R|ANKRD36C_ENST00000419039.2_Missense_Mutation_p.H438R					ankyrin repeat domain 36C									p.H662R(6)|p.H1411R(3)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						AAGGTCTTCATGCTTTCTTTT	0.383000													3	26					0	0	0.009096	0	0
SCN3A	6328	broad.mit.edu	37	2	166020180	166020180	+	Silent	SNP	C	C	T			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr2:166020180C>T	ENST00000283254.7	-	7	1109	c.642G>A	c.(640-642)gcG>gcA	p.A214A	SCN3A_ENST00000360093.3_Intron|SCN3A_ENST00000409101.3_Intron	NM_001081676.1|NM_006922.3	NP_001075145.1|NP_008853.3	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	214						voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.A214A(1)		NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	ATGTTCTCAACGCTGAGACAT	0.408000													26	32					0	0	0.007291	0	0
SRCRB4D	136853	broad.mit.edu	37	7	76029805	76029805	+	Silent	SNP	G	G	A			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr7:76029805G>A	ENST00000275560.3	-	4	620	c.273C>T	c.(271-273)gaC>gaT	p.D91D	ZP3_ENST00000336517.4_Intron	NM_080744.1	NP_542782.1	Q8WTU2	SRB4D_HUMAN	scavenger receptor cysteine rich domain containing, group B (4 domains)	91	SRCR 1.					extracellular region|membrane	scavenger receptor activity	p.D91D(1)		autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(9)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	21						CTACGTTGGCGTCCACCACGT	0.701000													6	7					0	0	0.001984	0	0
FRG1B	0	broad.mit.edu	37	20	29628263	29628263	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr20:29628263A>G	ENST00000278882.3	+	6	645	c.265A>G	c.(265-267)Att>Gtt	p.I89V	FRG1B_ENST00000439954.2_Missense_Mutation_p.I94V|FRG1B_ENST00000358464.4_Missense_Mutation_p.I89V														p.I89V(4)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TAGCTGCTTTATTAGATGCAA	0.363000													6	78					0	0	0.004482	0	0
C19orf47	126526	broad.mit.edu	37	19	40832339	40832339	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr19:40832339C>T	ENST00000582783.1	-	7	617	c.605G>A	c.(604-606)cGg>cAg	p.R202Q	C19orf47_ENST00000392035.2_Missense_Mutation_p.R135Q	NM_001256440.1	NP_001243369.1	Q8N9M1	CS047_HUMAN	chromosome 19 open reading frame 47	202								p.R135Q(1)		endometrium(5)|kidney(2)|lung(7)|ovary(3)|prostate(1)|skin(1)|urinary_tract(1)	20			Lung(22;0.000636)			AGCAGTGACCCGGCGCCGCTT	0.627000													11	26					0	0	0.010729	0	0
SLC27A4	10999	broad.mit.edu	37	9	131107632	131107632	+	Silent	SNP	C	C	G			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr9:131107632C>G	ENST00000300456.3	+	3	477	c.360C>G	c.(358-360)gcC>gcG	p.A120A	SLC27A4_ENST00000372870.1_Intron	NM_005094.3	NP_005085.2	Q6P1M0	S27A4_HUMAN	solute carrier family 27 (fatty acid transporter), member 4	120					long-chain fatty acid transport|transmembrane transport	integral to membrane	fatty acid transporter activity|nucleotide binding|protein binding	p.A120A(1)		autonomic_ganglia(1)|kidney(1)|large_intestine(1)|lung(7)|ovary(1)|prostate(2)	13						TCCTGCAGGCCCGGGGCCTGG	0.622000													16	29					0	0	0.004007	0	0
BAI1	575	broad.mit.edu	37	8	143603449	143603449	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr8:143603449C>T	ENST00000517894.1	+	21	4042	c.3148C>T	c.(3148-3150)Cgc>Tgc	p.R1050C	BAI1_ENST00000323289.5_Missense_Mutation_p.R1050C			O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	1050					axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding	p.R1050C(1)		NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(28)|ovary(4)|pancreas(1)|prostate(7)	57	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					CCGCCTCATCCGCAAGCGCTT	0.652000													10	30					0	0	0.010729	0	0
CTTNBP2	83992	broad.mit.edu	37	7	117386131	117386131	+	Missense_Mutation	SNP	A	A	T			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr7:117386131A>T	ENST00000160373.3	-	13	3462	c.3371T>A	c.(3370-3372)aTt>aAt	p.I1124N		NM_033427.2	NP_219499.1	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	1124								p.I1124N(1)		breast(3)|central_nervous_system(3)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(36)|ovary(4)|prostate(5)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	83	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		GCCGTGGAAAATGACATTATG	0.398000											OREG0003442	type=REGULATORY REGION|Gene=CTTNBP2|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	24	47					0	0	0.018920	0	0
MEGF10	84466	broad.mit.edu	37	5	126771182	126771182	+	Splice_Site	SNP	G	G	C			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr5:126771182G>C	ENST00000274473.6	+	17	2371		c.e17+1		MEGF10_ENST00000503335.2_Splice_Site	NM_032446.2	NP_115822.1	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10						cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup		p.?(1)		breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(28)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	68		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		TGCTCTCAACGTAAGTCTTGT	0.373000													15	17					0	0	0.002450	0	0
TET1	80312	broad.mit.edu	37	10	70446226	70446226	+	Silent	SNP	G	G	A			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr10:70446226G>A	ENST00000373644.4	+	11	5375	c.5166G>A	c.(5164-5166)aaG>aaA	p.K1722K		NM_030625.2	NP_085128.2	Q8NFU7	TET1_HUMAN	tet methylcytosine dioxygenase 1	1722					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding	p.K1722K(1)		breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(2)|ovary(5)|prostate(1)|upper_aerodigestive_tract(2)	21						TTGGCTCCAAGGAAGGAATGG	0.498000													51	75					0	0	0.014410	0	0
IGHG1	0	broad.mit.edu	37	14	106208715	106208715	+	RNA	SNP	T	T	G			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr14:106208715T>G	ENST00000390548.2	-	0	302																											TGTCACAAGATTTGGGCTCTG	0.582000													91	130					0	0	0.014410	0	0
HSPA6	3310	broad.mit.edu	37	1	161494903	161494903	+	Missense_Mutation	SNP	T	T	G			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr1:161494903T>G	ENST00000309758.4	+	1	868	c.455T>G	c.(454-456)tTc>tGc	p.F152C		NM_002155.3	NP_002146.2	P17066	HSP76_HUMAN	heat shock 70kDa protein 6 (HSP70B')	152					response to unfolded protein		ATP binding	p.F152C(2)		endometrium(3)|large_intestine(5)|lung(9)|prostate(2)|skin(2)	21	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			CCCGCCTATTTCAATGACTCG	0.632000													17	44					0	0	0.006122	0	0
SLC45A4	57210	broad.mit.edu	37	8	142222492	142222492	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr8:142222492C>T	ENST00000519067.1	-	7	2255	c.1952G>A	c.(1951-1953)gGc>gAc	p.G651D	SLC45A4_ENST00000024061.3_Missense_Mutation_p.G651D|SLC45A4_ENST00000433583.2_Missense_Mutation_p.G644D|SLC45A4_ENST00000517878.1_Missense_Mutation_p.G702D			Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	702					transport	integral to membrane		p.G651D(1)		breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			CAGGAAAGAGCCCACAGAGGC	0.627000													18	37					0	0	0.010504	0	0
PRSS58	136541	broad.mit.edu	37	7	141952406	141952406	+	Silent	SNP	A	A	C			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr7:141952406A>C	ENST00000552471.1	-	4	781	c.462T>G	c.(460-462)acT>acG	p.T154T	PRSS58_ENST00000547058.2_Silent_p.T154T			Q8IYP2	PRS58_HUMAN	protease, serine, 58	154	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity	p.T154T(2)		kidney(1)|large_intestine(2)|lung(11)|ovary(1)|prostate(2)|skin(2)	19						AGATGTTCACAGTTTGCAGTG	0.383000													9	229					0	0	0.006214	0	0
LPPR5	0	broad.mit.edu	37	1	99422183	99422183	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr1:99422183G>A	ENST00000370188.3	-	2	712	c.352C>T	c.(352-354)Cga>Tga	p.R118*	LPPR5_ENST00000263177.4_Nonsense_Mutation_p.R118*	NM_001010861.2	NP_001010861.1	Q32ZL2	LPPR5_HUMAN		118						integral to membrane	hydrolase activity	p.R118*(1)									CGGACAGTTCGGCGCACCAGC	0.358000													25	28					0	0	0.018920	0	0
ABCB1	5243	broad.mit.edu	37	7	87138593	87138593	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr7:87138593T>C	ENST00000265724.3	-	27	3904	c.3487A>G	c.(3487-3489)Aat>Gat	p.N1163D	ABCB1_ENST00000488737.2_5'UTR|ABCB1_ENST00000543898.1_Missense_Mutation_p.N1099D	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	1163	ABC transporter 2.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity	p.N1163D(1)		NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	AGACTTACATTAGGCAGTGAC	0.493000													23	178					0	0	0.014323	0	0
C1orf192	257177	broad.mit.edu	37	1	161334829	161334829	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr1:161334829A>G	ENST00000367974.1	-	5	465	c.460T>C	c.(460-462)Tcc>Ccc	p.S154P		NM_001013625.2	NP_001013647.2	Q5VTH2	CA192_HUMAN	chromosome 1 open reading frame 192	154								p.S154P(1)		endometrium(1)|large_intestine(3)|lung(5)|prostate(1)	10	all_cancers(52;4.64e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			TCATCTGGGGAATTGAGGTTG	0.498000													35	70					0	0	0.013726	0	0
DGKQ	1609	broad.mit.edu	37	4	956320	956320	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr4:956320T>C	ENST00000273814.3	-	18	2190	c.2117A>G	c.(2116-2118)gAg>gGg	p.E706G		NM_001347.3	NP_001338.2	P52824	DGKQ_HUMAN	diacylglycerol kinase, theta 110kDa	706	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|platelet activation|protein kinase C signaling cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to ATP|thrombin receptor signaling pathway	cytoskeleton|cytosol|nuclear speck|plasma membrane	activating transcription factor binding|ATP binding|diacylglycerol kinase activity|kinase binding|metal ion binding|phospholipase binding	p.E706G(1)		breast(1)|endometrium(2)|kidney(2)|lung(2)|prostate(2)	9			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			GGCGTCGGCCTCGTCCACAGA	0.657000													8	22					0	0	0.004482	0	0
TGOLN2	10618	broad.mit.edu	37	2	85553644	85553644	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr2:85553644T>C	ENST00000377386.3	-	2	1673	c.1211A>G	c.(1210-1212)cAc>cGc	p.H404R	TGOLN2_ENST00000409232.3_Missense_Mutation_p.H404R|TGOLN2_ENST00000444342.2_Missense_Mutation_p.H404R|TGOLN2_ENST00000409015.1_Missense_Mutation_p.H404R|TGOLN2_ENST00000398263.2_Missense_Mutation_p.H346R|TGOLN2_ENST00000282120.2_Missense_Mutation_p.H248R			O43493	TGON2_HUMAN	trans-golgi network protein 2	404						integral to membrane|nucleus|plasma membrane|trans-Golgi network|transport vesicle	protein binding	p.H404R(1)									CCGCTTGTTGTGATGAGCGAT	0.562000													26	41					0	0	0.005443	0	0
EFCAB14	9813	broad.mit.edu	37	1	47149017	47149017	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr1:47149017C>T	ENST00000371933.3	-	10	2243	c.1267G>A	c.(1267-1269)Gcc>Acc	p.A423T	EFCAB14_ENST00000544071.1_Missense_Mutation_p.A359T|EFCAB14-AS1_ENST00000418985.1_RNA|EFCAB14-AS1_ENST00000442839.1_RNA	NM_014774.2	NP_055589.1			EF-hand calcium binding domain 14									p.A423T(1)									CTTAGTTGGGCAGCTTTCTCA	0.388000													33	60					0	0	0.013726	0	0
ZZEF1	23140	broad.mit.edu	37	17	3980274	3980274	+	Missense_Mutation	SNP	T	T	G			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr17:3980274T>G	ENST00000381638.2	-	20	3123	c.2999A>C	c.(2998-3000)cAg>cCg	p.Q1000P	ZZEF1_ENST00000574474.1_5'UTR	NM_015113.3	NP_055928.3	O43149	ZZEF1_HUMAN	zinc finger, ZZ-type with EF-hand domain 1	1000							calcium ion binding|zinc ion binding	p.Q1000P(1)		central_nervous_system(1)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(17)|lung(19)|ovary(3)|pancreas(1)|prostate(3)|skin(8)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(3)	84						TGCCAGAAACTGGCCCACATC	0.363000													18	40					0	0	0.004990	0	0
TWF1	5756	broad.mit.edu	37	12	44189532	44189532	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr12:44189532C>A	ENST00000395510.2	-	9	1038	c.909G>T	c.(907-909)ttG>ttT	p.L303F	TWF1_ENST00000325127.4_Missense_Mutation_p.L337F|TWF1_ENST00000552521.1_Missense_Mutation_p.L205F|TWF1_ENST00000548315.1_Missense_Mutation_p.L310F	NM_001242397.1|NM_002822.4	NP_001229326.1|NP_002813.3	Q12792	TWF1_HUMAN	twinfilin actin-binding protein 1	303	ADF-H 2.					actin cytoskeleton|cytoplasm	actin binding|protein tyrosine kinase activity	p.L303F(1)		endometrium(2)|large_intestine(6)|lung(4)|prostate(1)|stomach(1)	14	all_cancers(12;0.00125)	Lung NSC(34;0.0804)|all_lung(34;0.181)		GBM - Glioblastoma multiforme(48;0.0474)		AGTCTGCAGTCAACTCATCCC	0.383000													38	59					8.69298e-16	1.00304e-15	0.006999	1	0
MAP3K10	4294	broad.mit.edu	37	19	40698519	40698519	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr19:40698519A>G	ENST00000253055.3	+	1	869	c.581A>G	c.(580-582)cAc>cGc	p.H194R	MAP3K10_ENST00000593906.1_Intron	NM_002446.3	NP_002437.2	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase 10	194	Protein kinase.				activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity	p.H194R(2)		NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	24						GTGCCACCTCACGTGCTGGTC	0.642000													10	17					0	0	0.010729	0	0
IGKV2-24	0	broad.mit.edu	37	2	89475970	89475970	+	RNA	SNP	G	G	C			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr2:89475970G>C	ENST00000484817.1	-	0	231																											AGTCTTGGAGGCTGGCCTGGC	0.522000													6	213					0	0	0.001168	0	0
FBLN2	2199	broad.mit.edu	37	3	13663379	13663379	+	Missense_Mutation	SNP	G	G	T			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr3:13663379G>T	ENST00000404922.3	+	9	2379	c.2260G>T	c.(2260-2262)Gat>Tat	p.D754Y	FBLN2_ENST00000492059.1_Missense_Mutation_p.D754Y|FBLN2_ENST00000535798.1_Intron|FBLN2_ENST00000295760.7_Intron	NM_001004019.1	NP_001004019.1	P98095	FBLN2_HUMAN	fibulin 2	753	EGF-like 3; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent	p.D754Y(1)|p.D173Y(1)		haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(10)|ovary(3)|prostate(3)|urinary_tract(1)	24			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			GCTCTGTGCCGATGGCTATAT	0.612000													11	27					3.07112e-06	3.35031e-06	0.010729	1	0
LAMA4	3910	broad.mit.edu	37	6	112441551	112441551	+	Missense_Mutation	SNP	T	T	G			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr6:112441551T>G	ENST00000230538.7	-	33	4997	c.4600A>C	c.(4600-4602)Aat>Cat	p.N1534H	LAMA4_ENST00000522006.1_Missense_Mutation_p.N1527H|LAMA4_ENST00000389463.4_Missense_Mutation_p.N1527H|LAMA4_ENST00000424408.2_Missense_Mutation_p.N1527H	NM_001105206.2	NP_001098676.2	Q16363	LAMA4_HUMAN	laminin, alpha 4	1534	Laminin G-like 4.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding	p.N1527H(1)		NS(1)|breast(6)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(18)|lung(42)|ovary(4)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(8)	100		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		TGACCAACATTAAACATGTAA	0.418000													20	16					0	0	0.008871	0	0
ATRX	546	broad.mit.edu	37	X	76891438	76891438	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chrX:76891438A>G	ENST00000373344.5	-	16	4881	c.4667T>C	c.(4666-4668)aTg>aCg	p.M1556T	ATRX_ENST00000395603.3_Missense_Mutation_p.M1518T|ATRX_ENST00000480283.1_5'UTR	NM_000489.3	NP_000480.2	P46100	ATRX_HUMAN	alpha thalassemia/mental retardation syndrome X-linked	1556					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding	p.M1556T(2)|p.?(1)		bone(1)|breast(6)|central_nervous_system(31)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(15)|kidney(14)|large_intestine(1)|liver(1)|lung(40)|ovary(2)|pancreas(13)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	145					Phosphatidylserine(DB00144)	TTTGATAACCATATTTCTATG	0.338000			"""Mis, F, N"""		"""Pancreatic neuroendocrine tumors, paediatric GBM"""		ATR-X (alpha thalassemia/mental retardation) syndrome						18	5					0	0	0.004990	0	0
IFT122	55764	broad.mit.edu	37	3	129188218	129188218	+	Missense_Mutation	SNP	C	C	G			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr3:129188218C>G	ENST00000296266.3	+	10	1119	c.927C>G	c.(925-927)gaC>gaG	p.D309E	IFT122_ENST00000440957.2_Missense_Mutation_p.D49E|IFT122_ENST00000504021.1_Missense_Mutation_p.D152E|IFT122_ENST00000349441.2_Missense_Mutation_p.D147E|IFT122_ENST00000348417.2_Missense_Mutation_p.D258E|IFT122_ENST00000507564.1_Missense_Mutation_p.D250E|IFT122_ENST00000431818.2_Missense_Mutation_p.D108E|IFT122_ENST00000347300.2_Missense_Mutation_p.D199E	NM_052985.2	NP_443711.2	Q9HBG6	IF122_HUMAN	intraflagellar transport 122 homolog (Chlamydomonas)	258					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium		p.D309E(1)		breast(3)|cervix(1)|endometrium(9)|large_intestine(10)|lung(21)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	52						CTGTGGCTGACTGGGGACAGA	0.443000													63	79					0	0	0.014410	0	0
MKI67	4288	broad.mit.edu	37	10	129901213	129901213	+	Missense_Mutation	SNP	C	C	G			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr10:129901213C>G	ENST00000368654.3	-	13	9266	c.8891G>C	c.(8890-8892)cGg>cCg	p.R2964P	MKI67_ENST00000368653.3_Missense_Mutation_p.R2604P	NM_002417.4	NP_002408.3	P46013	KI67_HUMAN	marker of proliferation Ki-67	2964					cell proliferation	nucleolus	ATP binding|protein C-terminus binding	p.R2964P(1)		NS(2)|autonomic_ganglia(1)|breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(5)|kidney(7)|large_intestine(30)|lung(64)|ovary(4)|pancreas(1)|prostate(4)|skin(2)|soft_tissue(1)|stomach(10)|upper_aerodigestive_tract(4)|urinary_tract(4)	159		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TTTAGGGGCCCGAAGAACTCT	0.493000													58	133					0	0	0.014410	0	0
SPAG16	79582	broad.mit.edu	37	2	214794778	214794778	+	Missense_Mutation	SNP	C	C	T	rs142357329	byFrequency	TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr2:214794778C>T	ENST00000331683.5	+	12	1404	c.1309C>T	c.(1309-1311)Cgc>Tgc	p.R437C	SPAG16_ENST00000374309.3_Missense_Mutation_p.R343C	NM_024532.4	NP_078808.3	Q8N0X2	SPG16_HUMAN	sperm associated antigen 16	437					cilium assembly	cilium axoneme|flagellar axoneme		p.R437C(2)		endometrium(4)|kidney(1)|large_intestine(15)|lung(27)|ovary(1)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	56		Renal(323;0.00461)		UCEC - Uterine corpus endometrioid carcinoma (47;0.0525)|Epithelial(149;7.07e-07)|all cancers(144;7.96e-05)|Lung(261;0.00255)|LUSC - Lung squamous cell carcinoma(224;0.00599)		AGGACACAGCCGCGCAGTGTG	0.438000													49	50					0	0	0.014410	0	0
TPTE2	93492	broad.mit.edu	37	13	20049751	20049751	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr13:20049751C>A	ENST00000400230.2	-	5	236	c.192G>T	c.(190-192)aaG>aaT	p.K64N	TPTE2_ENST00000255310.6_Intron|TPTE2_ENST00000457266.2_Intron|TPTE2_ENST00000382977.4_Missense_Mutation_p.K64N|TPTE2_ENST00000390680.2_Intron|TPTE2_ENST00000382978.1_Missense_Mutation_p.K64N|TPTE2_ENST00000382975.4_Missense_Mutation_p.K64N|TPTE2_ENST00000400103.2_Intron			Q6XPS3	TPTE2_HUMAN	transmembrane phosphoinositide 3-phosphatase and tensin homolog 2	64						endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.K64N(1)		NS(2)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(7)|large_intestine(8)|lung(21)|pancreas(1)|prostate(8)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	65		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		GCACAATTTTCTTAATCTTGC	0.299000													20	33					2.27731e-05	2.43997e-05	0.012319	1	0
PRSS50	29122	broad.mit.edu	37	3	46759103	46759103	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr3:46759103G>A	ENST00000460241.1	-	7	1801	c.131C>T	c.(130-132)cCg>cTg	p.P44L	PRSS50_ENST00000315170.7_Missense_Mutation_p.P44L			Q9UI38	TSP50_HUMAN	protease, serine, 50	44					proteolysis	endoplasmic reticulum	serine-type endopeptidase activity|threonine-type endopeptidase activity	p.P44L(1)		endometrium(2)|kidney(2)|large_intestine(1)|lung(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	11						CAGCGCCCCCGGGGCTTCCCC	0.706000													12	17					0	0	0.010729	0	0
ACAP1	9744	broad.mit.edu	37	17	7250419	7250419	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr17:7250419C>T	ENST00000158762.3	+	14	1407	c.1201C>T	c.(1201-1203)Cct>Tct	p.P401S		NM_014716.3	NP_055531.1	Q15027	ACAP1_HUMAN	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	401					intracellular signal transduction|lipid metabolic process|protein transport|regulation of ARF GTPase activity		ARF GTPase activator activity|phospholipase C activity|protein binding|zinc ion binding	p.P401S(1)		NS(1)|breast(5)|cervix(3)|endometrium(4)|kidney(1)|large_intestine(7)|liver(1)|lung(6)|prostate(3)|skin(1)|urinary_tract(1)	33						GGGAAGGGAGCCTGGGGGAGT	0.677000													7	40					0	0	0.001984	0	0
XIST	0	broad.mit.edu	37	X	73066388	73066388	+	RNA	SNP	G	G	T			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chrX:73066388G>T	ENST00000429829.1	-	0	6200					NR_001564.2																						AATGAGCAGTGTGCGATTACG	0.463000													63	15					2.01871e-26	2.37496e-26	0.014410	1	0
NID1	4811	broad.mit.edu	37	1	236156998	236156998	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr1:236156998C>T	ENST00000264187.6	-	13	2784	c.2702G>A	c.(2701-2703)cGc>cAc	p.R901H	NID1_ENST00000366595.3_Missense_Mutation_p.R768H	NM_002508.2	NP_002499.2	P14543	NID1_HUMAN	nidogen 1	901	Thyroglobulin type-1.				cell-matrix adhesion	basement membrane	calcium ion binding	p.R901H(1)		breast(4)|endometrium(9)|kidney(1)|large_intestine(23)|lung(20)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(1)	66	Ovarian(103;0.0544)|Breast(184;0.23)	all_cancers(173;0.00491)|Prostate(94;0.184)|Acute lymphoblastic leukemia(190;0.229)	OV - Ovarian serous cystadenocarcinoma(106;0.00162)		Becaplermin(DB00102)|Urokinase(DB00013)	GCGGCCGTCGCGATCCACGCA	0.697000													5	12					0	0	0.001168	0	0
ADH1B	125	broad.mit.edu	37	4	100237249	100237249	+	Missense_Mutation	SNP	G	G	T			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr4:100237249G>T	ENST00000305046.8	-	5	440	c.373C>A	c.(373-375)Cag>Aag	p.Q125K	ADH1B_ENST00000394887.3_Missense_Mutation_p.Q85K			P00325	ADH1B_HUMAN	alcohol dehydrogenase 1B (class I), beta polypeptide	125					ethanol oxidation|xenobiotic metabolic process	cytosol	alcohol dehydrogenase activity, zinc-dependent|zinc ion binding	p.Q125K(1)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(3)|large_intestine(5)|lung(12)|ovary(1)|prostate(2)|skin(2)|urinary_tract(1)	33				OV - Ovarian serous cystadenocarcinoma(123;1.02e-07)	Fomepizole(DB01213)|NADH(DB00157)	GTGCCATCCTGCAGGGTCCCC	0.547000													20	33					6.33239e-15	7.16874e-15	0.010504	1	0
CUX1	1523	broad.mit.edu	37	7	101845118	101845118	+	Silent	SNP	C	C	T			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr7:101845118C>T	ENST00000360264.3	+	18	2594	c.2574C>T	c.(2572-2574)ggC>ggT	p.G858G	CUX1_ENST00000547394.2_Intron|CUX1_ENST00000560541.1_Intron|CUX1_ENST00000437600.4_Intron|CUX1_ENST00000292535.7_Silent_p.G847G|CUX1_ENST00000292538.4_Intron|CUX1_ENST00000425244.2_Intron|CUX1_ENST00000546411.2_Silent_p.G745G|CUX1_ENST00000556210.1_Silent_p.G689G|CUX1_ENST00000550008.2_Silent_p.G791G|CUX1_ENST00000393824.3_Intron|CUX1_ENST00000549414.2_Silent_p.G825G	NM_001202543.1	NP_001189472.1	P39880	CUX1_HUMAN	cut-like homeobox 1	847					negative regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.G847G(1)		breast(2)|central_nervous_system(1)|cervix(2)|endometrium(6)|kidney(3)|large_intestine(8)|lung(26)|ovary(7)|pancreas(1)|prostate(6)|skin(2)|stomach(1)|urinary_tract(5)	70						AAGAAACGGGCGGCGGGAAAG	0.687000													5	75					0	0	0.014758	0	0
MUC16	94025	broad.mit.edu	37	19	9061392	9061392	+	Missense_Mutation	SNP	G	G	C			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr19:9061392G>C	ENST00000397910.4	-	3	26257	c.26054C>G	c.(26053-26055)aCa>aGa	p.T8685R		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	8687	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.T8685R(2)|p.T4318R(1)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GGAAACACTTGTATTCCCCAG	0.458000													35	45					0	0	0.017118	0	0
CPS1	1373	broad.mit.edu	37	2	211541794	211541794	+	Silent	SNP	C	C	T			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr2:211541794C>T	ENST00000233072.5	+	37	4534	c.4338C>T	c.(4336-4338)gtC>gtT	p.V1446V	CPS1_ENST00000430249.2_Silent_p.V1452V|CPS1_ENST00000451903.2_Silent_p.V995V	NM_001875.4	NP_001866.2	P31327	CPSM_HUMAN	carbamoyl-phosphate synthase 1, mitochondrial	1446					carbamoyl phosphate biosynthetic process|citrulline biosynthetic process|glutamine metabolic process|glycogen catabolic process|nitric oxide metabolic process|positive regulation of vasodilation|response to lipopolysaccharide|triglyceride catabolic process|urea cycle	mitochondrial nucleoid	ATP binding|carbamoyl-phosphate synthase (ammonia) activity	p.V1446V(1)		breast(1)|central_nervous_system(4)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(17)|lung(85)|ovary(8)|pancreas(1)|prostate(6)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(2)	142				Epithelial(149;0.00697)|Lung(261;0.0521)|LUSC - Lung squamous cell carcinoma(261;0.0544)|all cancers(144;0.0843)		CTAAATTTGTCCATGATAATT	0.378000													48	89					0	0	0.014410	0	0
MYLK	4638	broad.mit.edu	37	3	123451902	123451902	+	Missense_Mutation	SNP	G	G	C			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr3:123451902G>C	ENST00000360772.3	-	12	1735	c.1357C>G	c.(1357-1359)Ccc>Gcc	p.P453A	MYLK_ENST00000346322.5_Intron|MYLK_ENST00000475616.1_Missense_Mutation_p.P453A|MYLK_ENST00000359169.1_Missense_Mutation_p.P453A|MYLK_ENST00000360304.3_Missense_Mutation_p.P453A			Q15746	MYLK_HUMAN	myosin light chain kinase	453	Ig-like C2-type 3.				aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity	p.P453A(2)		NS(2)|breast(4)|central_nervous_system(1)|endometrium(24)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(17)|lung(37)|ovary(7)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(2)	113		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		CTCCTCACGGGGGTGCCTTCC	0.572000													6	26					0	0	0.001984	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96521777	96521777	+	Missense_Mutation	SNP	T	T	C	rs77768218		TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr2:96521777T>C	ENST00000456556.1	-	63	4316	c.4232A>G	c.(4231-4233)cAt>cGt	p.H1411R	ANKRD36C_ENST00000420871.2_Missense_Mutation_p.H662R|ANKRD36C_ENST00000419039.2_Missense_Mutation_p.H438R					ankyrin repeat domain 36C									p.H662R(6)|p.H1411R(3)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						AAGGTCTTCATGCTTTCTTTT	0.383000													3	26					0	0	0.009096	0	0
SIRPB1	10326	broad.mit.edu	37	20	1600530	1600530	+	Silent	SNP	G	G	A			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr20:1600530G>A	ENST00000381605.4	-	1	125	c.61C>T	c.(61-63)Ctg>Ttg	p.L21L	RP4-576H24.4_ENST00000564763.1_Silent_p.L21L|SIRPB1_ENST00000568365.1_Silent_p.L21L|SIRPB1_ENST00000381596.1_5'UTR|SIRPB1_ENST00000381603.3_Silent_p.L21L|SIRPB1_ENST00000279477.7_Silent_p.L21L	NM_006065.3	NP_006056.2	O00241	SIRB1_HUMAN	signal-regulatory protein beta 1	21					cell junction assembly|cell surface receptor linked signaling pathway	integral to plasma membrane	protein binding	p.L21L(1)		central_nervous_system(2)|kidney(2)|large_intestine(4)|lung(16)|ovary(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	31						AGTCTCCCCAGCAGTAGCGTC	0.562000													28	41					0	0	0.007291	0	0
SCN3A	6328	broad.mit.edu	37	2	166020180	166020180	+	Silent	SNP	C	C	T			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr2:166020180C>T	ENST00000283254.7	-	7	1109	c.642G>A	c.(640-642)gcG>gcA	p.A214A	SCN3A_ENST00000409101.3_Intron|SCN3A_ENST00000360093.3_Intron	NM_001081676.1|NM_006922.3	NP_001075145.1|NP_008853.3	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	214						voltage-gated sodium channel complex	voltage-gated sodium channel activity	p.A214A(1)		NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	ATGTTCTCAACGCTGAGACAT	0.408000													26	32					0	0	0.007291	0	0
NOX3	50508	broad.mit.edu	37	6	155761273	155761274	+	Splice_Site	INS	-	-	A			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr6:155761273_155761274insA	ENST00000159060.2	-	6	589		c.e6-2			NM_015718.2	NP_056533.1	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3								electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	45		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		GGTTGTGTTCTaaaaaaaacaa	0.356													28	33	---	---	---	---					
BBS9	27241	broad.mit.edu	37	7	33312723	33312723	+	Frame_Shift_Del	DEL	T	T	-			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr7:33312723delT	ENST00000242067.6	+	8	1323	c.802delT	c.(802-804)ttfs	p.F269fs	BBS9_ENST00000425508.2_Frame_Shift_Del_p.F224fs|BBS9_ENST00000396127.2_Frame_Shift_Del_p.F269fs|BBS9_ENST00000355070.2_Frame_Shift_Del_p.F269fs|BBS9_ENST00000354265.4_Frame_Shift_Del_p.F269fs|BBS9_ENST00000350941.3_Frame_Shift_Del_p.F269fs	NM_198428.2	NP_940820.1	Q3SYG4	PTHB1_HUMAN	Bardet-Biedl syndrome 9	269					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding		BBS9/PKD1L1(2)	NS(1)|autonomic_ganglia(1)|endometrium(1)|kidney(2)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	50			GBM - Glioblastoma multiforme(11;0.0894)			TGAGAGAAACTTTTTTTGCCT	0.393									Bardet-Biedl syndrome				7	511	---	---	---	---					
TRBV7-6	0	broad.mit.edu	37	7	142139683	142139684	+	RNA	INS	-	-	A			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr7:142139683_142139684insA	ENST00000390374.3	-	0	94																											cctacacacaGAAAAAAAAATG	0.490													8	243	---	---	---	---					
OR51D1	390038	broad.mit.edu	37	11	4661689	4661690	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr11:4661689_4661690delCT	ENST00000357605.2	+	1	745_746	c.669_670delCT	c.(667-672)gactfs	p.DS223fs		NM_001004751.2	NP_001004751.1	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D, member 1	223					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|liver(2)|lung(14)|prostate(1)|skin(2)|urinary_tract(1)	27		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGGGTGTGGACTCTCTCTTCAT	0.495													40	76	---	---	---	---					
PPP1R13B	23368	broad.mit.edu	37	14	104205266	104205268	+	In_Frame_Del	DEL	GAC	GAC	-			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-10A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	ecd9e666-76cf-4984-a6b7-01764f387579	g.chr14:104205266_104205268delGAC	ENST00000202556.9	-	13	2967_2969	c.2685_2687delGTC	c.(2683-2688)gct>gc	p.AS895del	PPP1R13B_ENST00000555391.1_5'UTR|PPP1R13B_ENST00000423488.2_In_Frame_Del_p.AS314del	NM_015316.2	NP_056131.2	Q96KQ4	ASPP1_HUMAN	protein phosphatase 1, regulatory subunit 13B	895					apoptosis|induction of apoptosis|negative regulation of cell cycle	cytoplasm|nucleus|plasma membrane	protein binding			endometrium(6)|kidney(2)|large_intestine(7)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.173)|all_epithelial(191;0.131)|Melanoma(154;0.155)				TCCTTCCAGAGACGCGTCTAGGA	0.626													40	88	---	---	---	---					
NOX3	50508	broad.mit.edu	37	6	155761273	155761274	+	Splice_Site	INS	-	-	A			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr6:155761273_155761274insA	ENST00000159060.2	-	6	589		c.e6-2			NM_015718.2	NP_056533.1	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3								electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	45		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		GGTTGTGTTCTaaaaaaaacaa	0.356													28	33	---	---	---	---					
FAM115C	285966	broad.mit.edu	37	7	143417404	143417405	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr7:143417404_143417405delCT	ENST00000441159.2	+	3	1318_1319	c.1252_1253delCT	c.(1252-1254)cfs	p.L418fs	FAM115C_ENST00000425618.2_Frame_Shift_Del_p.L137fs|FAM115C_ENST00000411935.1_Frame_Shift_Del_p.L254fs|FAM115C_ENST00000409703.3_Frame_Shift_Del_p.L254fs|FAM115C_ENST00000444908.2_Frame_Shift_Del_p.L418fs|FAM115C_ENST00000357344.4_Frame_Shift_Del_p.L418fs|FAM115C_ENST00000411497.2_Frame_Shift_Del_p.L137fs			A6NFQ2	F115C_HUMAN	family with sequence similarity 115, member C	418										endometrium(2)|large_intestine(4)|lung(2)|prostate(1)	9						CCGCAAGGCGCTCTCTCAATTC	0.530													7	11	---	---	---	---					
OR51D1	390038	broad.mit.edu	37	11	4661689	4661690	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr11:4661689_4661690delCT	ENST00000357605.2	+	1	745_746	c.669_670delCT	c.(667-672)gactfs	p.DS223fs		NM_001004751.2	NP_001004751.1	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D, member 1	223					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			autonomic_ganglia(1)|breast(2)|central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|liver(2)|lung(14)|prostate(1)|skin(2)|urinary_tract(1)	27		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGGGTGTGGACTCTCTCTTCAT	0.495													40	76	---	---	---	---					
PPP1R13B	23368	broad.mit.edu	37	14	104205266	104205268	+	In_Frame_Del	DEL	GAC	GAC	-			TCGA-G9-6496-01A-11D-1786-08	TCGA-G9-6496-11A-01D-1786-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	259386a0-60a4-4990-a3c3-36b9bab40927	571e38b2-e5df-48f5-a2e0-4ab54b1e47c5	g.chr14:104205266_104205268delGAC	ENST00000202556.9	-	13	2967_2969	c.2685_2687delGTC	c.(2683-2688)gct>gc	p.AS895del	PPP1R13B_ENST00000555391.1_5'UTR|PPP1R13B_ENST00000423488.2_In_Frame_Del_p.AS314del	NM_015316.2	NP_056131.2	Q96KQ4	ASPP1_HUMAN	protein phosphatase 1, regulatory subunit 13B	895					apoptosis|induction of apoptosis|negative regulation of cell cycle	cytoplasm|nucleus|plasma membrane	protein binding			endometrium(6)|kidney(2)|large_intestine(7)|lung(16)|ovary(1)|upper_aerodigestive_tract(1)	33		all_cancers(154;0.173)|all_epithelial(191;0.131)|Melanoma(154;0.155)				TCCTTCCAGAGACGCGTCTAGGA	0.626													40	88	---	---	---	---					
