Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GANC	2595	broad.mit.edu	37	15	42631922	42631922	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr15:42631922C>A	ENST00000318010.8	+	17	2139	c.1899C>A	c.(1897-1899)taC>taA	p.Y633*		NM_198141.2	NP_937784.2	Q8TET4	GANC_HUMAN	glucosidase, alpha; neutral C	633					carbohydrate metabolic process		carbohydrate binding|maltose alpha-glucosidase activity			breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		all_cancers(109;3.08e-16)|all_epithelial(112;7.48e-15)|Lung NSC(122;3.08e-09)|all_lung(180;1.48e-08)|Melanoma(134;0.0574)|Colorectal(260;0.153)		GBM - Glioblastoma multiforme(94;1.06e-06)		TGCGTTGGTACCAGGCTGGAG	0.562000													3	106					1.23904e-05	1.33896e-05	1	1	0
PRSS23	11098	broad.mit.edu	37	11	86519574	86519574	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr11:86519574G>A	ENST00000280258.5	+	2	1314	c.889G>A	c.(889-891)Gtc>Atc	p.V297I	PRSS23_ENST00000441050.1_Missense_Mutation_p.V265I|PRSS23_ENST00000533902.2_Intron	NM_007173.4	NP_009104.1	O95084	PRS23_HUMAN	protease, serine, 23	297					proteolysis	extracellular region|nucleus	serine-type endopeptidase activity			central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(9)|pancreas(1)|skin(1)|stomach(1)|urinary_tract(1)	18		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CTTCTGTGACGTCAAAGACGA	0.557000													8	72					0	0	1	0	0
MYO15A	51168	broad.mit.edu	37	17	18022689	18022689	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr17:18022689G>A	ENST00000205890.5	+	2	913	c.575G>A	c.(574-576)cGc>cAc	p.R192H		NM_016239.3	NP_057323.3	Q9UKN7	MYO15_HUMAN	myosin XVA	192	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			breast(5)|central_nervous_system(2)|endometrium(17)|kidney(3)|large_intestine(16)|lung(27)|ovary(3)|pancreas(1)|prostate(6)|skin(13)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	99	all_neural(463;0.228)					AGGTTCCCCCGCAGCCGCAGC	0.711000													3	25					0	0	1	0	0
CCDC61	729440	broad.mit.edu	37	19	46518613	46518613	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr19:46518613C>A	ENST00000263284.2	+	8	944	c.944C>A	c.(943-945)gCg>gAg	p.A315E	CCDC61_ENST00000595358.1_Missense_Mutation_p.A258E|CCDC61_ENST00000594087.1_Intron|CCDC61_ENST00000536603.1_Intron					coiled-coil domain containing 61											endometrium(3)|kidney(3)|large_intestine(1)|lung(5)|ovary(1)	13		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00221)|GBM - Glioblastoma multiforme(486;0.0233)|Epithelial(262;0.164)		CTCGAGGAGGCGAAGGCATCG	0.741000													6	24					0.00198382	0.00204486	1	1	0
UBBP4	0	broad.mit.edu	37	17	21731144	21731144	+	Missense_Mutation	SNP	T	T	G	rs149119138	by1000genomes	TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr17:21731144T>G	ENST00000584755.1	+	2	843	c.446T>G	c.(445-447)cTg>cGg	p.L149R	UBBP4_ENST00000583708.1_3'UTR|UBBP4_ENST00000584398.1_3'UTR|UBBP4_ENST00000578713.1_Missense_Mutation_p.L149R														p.L149R(18)		endometrium(9)|kidney(4)|lung(4)|prostate(3)|urinary_tract(4)	24						GTCCTGCGTCTGAGAGGTGGT	0.542000													3	56					0	0	1	0	0
COL24A1	255631	broad.mit.edu	37	1	86210365	86210365	+	Missense_Mutation	SNP	T	T	G			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr1:86210365T>G	ENST00000370571.2	-	57	5022	c.4656A>C	c.(4654-4656)gaA>gaC	p.E1552D	COL24A1_ENST00000436319.1_Missense_Mutation_p.E1531D	NM_152890.5	NP_690850.2	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1	1552	Fibrillar collagen NC1.				cell adhesion	collagen	extracellular matrix structural constituent			NS(3)|central_nervous_system(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(9)|liver(1)|lung(56)|ovary(4)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	101				all cancers(265;0.0627)|Epithelial(280;0.0689)		ATACTTTTTGTTCACAGTTAA	0.373000													13	62					0	0	1	0	0
ZFP36L1	677	broad.mit.edu	37	14	69256720	69256720	+	Missense_Mutation	SNP	G	G	C			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr14:69256720G>C	ENST00000439696.2	-	2	848	c.547C>G	c.(547-549)Cgt>Ggt	p.R183G	ZFP36L1_ENST00000336440.3_Missense_Mutation_p.R183G|ZFP36L1_ENST00000555997.1_3'UTR	NM_001244701.1|NM_004926.3	NP_001231630.1|NP_004917.2	Q07352	TISB_HUMAN	ZFP36 ring finger protein-like 1	183					regulation of mRNA stability	cytosol|nucleus	DNA binding|mRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(4)|kidney(1)|large_intestine(1)|liver(2)|lung(9)|ovary(1)|prostate(2)|urinary_tract(1)	21				all cancers(60;0.00203)|BRCA - Breast invasive adenocarcinoma(234;0.00205)|OV - Ovarian serous cystadenocarcinoma(108;0.0401)		GCCAGGGCACGGCGCTCTTCA	0.672000											OREG0022753	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	19					0	0	1	0	0
LIG1	3978	broad.mit.edu	37	19	48621022	48621022	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr19:48621022C>A	ENST00000263274.7	-	26	2875	c.2456G>T	c.(2455-2457)aGc>aTc	p.S819I	LIG1_ENST00000427526.2_Missense_Mutation_p.S788I|LIG1_ENST00000536218.1_Missense_Mutation_p.S751I	NM_000234.1	NP_000225.1	P18858	DNLI1_HUMAN	ligase I, DNA, ATP-dependent	819					anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			breast(1)|cervix(1)|endometrium(7)|kidney(1)|large_intestine(9)|lung(22)|prostate(2)|skin(1)	44		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)	AGGGCGTGGGCTGGGCAGCAC	0.622000								Nucleotide excision repair (NER)					5	22					0.184627	0.184627	1	1	0
SPEF2	79925	broad.mit.edu	37	5	35692786	35692786	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr5:35692786A>G	ENST00000440995.2	+	12	1859	c.1859A>G	c.(1858-1860)gAt>gGt	p.D620G	SPEF2_ENST00000509059.1_Missense_Mutation_p.D620G|SPEF2_ENST00000356031.3_Missense_Mutation_p.D620G|CTD-2113L7.1_ENST00000510433.1_RNA			Q9C093	SPEF2_HUMAN	sperm flagellar 2	620					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(15)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	37	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GATGAAGAAGATGCTCTACCA	0.393000													3	59					0	0	1	0	0
ITIH2	3698	broad.mit.edu	37	10	7751115	7751115	+	Missense_Mutation	SNP	T	T	A			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr10:7751115T>A	ENST00000358415.4	+	4	489	c.323T>A	c.(322-324)gTt>gAt	p.V108D	ITIH2_ENST00000480387.1_Intron|ITIH2_ENST00000379587.4_Missense_Mutation_p.V97D	NM_002216.2	NP_002207.2	P19823	ITIH2_HUMAN	inter-alpha-trypsin inhibitor heavy chain 2	108	VIT.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			NS(2)|breast(1)|endometrium(8)|kidney(1)|large_intestine(17)|lung(25)|ovary(1)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	64						GTGTTTGATGTTCAGATCCCC	0.453000													21	55					0	0	1	0	0
RRN3P2	0	broad.mit.edu	37	16	29110438	29110438	+	RNA	SNP	T	T	C			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr16:29110438T>C	ENST00000564580.1	+	0	1111																		p.L368P(6)									TTGCAGTATCTTCAGAGTCTG	0.328000													3	34					0	0	1	0	0
IL25	0	broad.mit.edu	37	14	23844881	23844881	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr14:23844881G>A	ENST00000329715.2	+	2	584	c.326G>A	c.(325-327)cGt>cAt	p.R109H	IL25_ENST00000397242.2_Missense_Mutation_p.R93H	NM_022789.3	NP_073626.1	Q9H293	IL25_HUMAN	interleukin 25	109					inflammatory response	extracellular space|membrane	cytokine activity|interleukin-17E receptor binding			NS(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)	9	all_cancers(95;2e-05)			GBM - Glioblastoma multiforme(265;0.00665)|READ - Rectum adenocarcinoma(4;0.0276)|Colorectal(4;0.0396)		TACCACGCCCGTTGCCTGTGC	0.632000													12	103					0	0	1	0	0
CCDC174	51244	broad.mit.edu	37	3	14712672	14712672	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr3:14712672A>G	ENST00000383794.3	+	11	1448	c.1375A>G	c.(1375-1377)Atg>Gtg	p.M459V	CCDC174_ENST00000303688.7_Missense_Mutation_p.M383V	NM_016474.4	NP_057558.3			coiled-coil domain containing 174																		TCTGGATGACATGATTTCCTA	0.483000													33	48					0	0	1	0	0
COL6A3	1293	broad.mit.edu	37	2	238289893	238289893	+	Missense_Mutation	SNP	G	G	A	rs115881121	by1000genomes	TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr2:238289893G>A	ENST00000295550.4	-	5	2014	c.1562C>T	c.(1561-1563)tCg>tTg	p.S521L	COL6A3_ENST00000347401.3_Missense_Mutation_p.S320L|COL6A3_ENST00000409809.1_Missense_Mutation_p.S315L|COL6A3_ENST00000346358.4_Missense_Mutation_p.S521L|COL6A3_ENST00000353578.4_Missense_Mutation_p.S315L|COL6A3_ENST00000472056.1_Missense_Mutation_p.S114L|COL6A3_ENST00000392003.2_Missense_Mutation_p.S114L|COL6A3_ENST00000392004.3_Missense_Mutation_p.S315L	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	521	Nonhelical region.|VWFA 3.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity	p.S521L(1)		breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GTACAGGGCCGAGCCGTCCAG	0.517000													29	65					0	0	1	0	0
DAB2IP	153090	broad.mit.edu	37	9	124532879	124532879	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr9:124532879G>A	ENST00000408936.3	+	11	2136	c.1954G>A	c.(1954-1956)Gca>Aca	p.A652T	DAB2IP_ENST00000259371.2_Missense_Mutation_p.A624T|DAB2IP_ENST00000309989.1_Missense_Mutation_p.A528T			Q5VWQ8	DAB2P_HUMAN	DAB2 interacting protein	652					activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity	p.A528>?(1)		breast(3)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(8)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	27						CGTCCACACAGCACTGAGCAC	0.612000													3	40					0	0	1	0	0
ARMC3	219681	broad.mit.edu	37	10	23287302	23287302	+	Silent	SNP	G	G	A			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr10:23287302G>A	ENST00000298032.5	+	11	1485	c.1401G>A	c.(1399-1401)gcG>gcA	p.A467A	ARMC3_ENST00000376528.4_Silent_p.A204A|ARMC3_ENST00000409049.3_Silent_p.A467A|ARMC3_ENST00000409983.3_Silent_p.A467A	NM_173081.3	NP_775104.2	Q5W041	ARMC3_HUMAN	armadillo repeat containing 3	467							binding			breast(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						CCGCAACTGCGTGTGACGTTG	0.458000													13	15					0	0	1	0	0
ANKRD52	283373	broad.mit.edu	37	12	56647135	56647135	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr12:56647135G>A	ENST00000267116.7	-	10	1158	c.1037C>T	c.(1036-1038)gCt>gTt	p.A346V		NM_173595.3	NP_775866.2	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	346							protein binding			endometrium(9)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(1)	29						ATATCGAGCAGCCACATGCAG	0.582000													59	94					0	0	1	0	0
KIAA0100	9703	broad.mit.edu	37	17	26951278	26951278	+	Silent	SNP	G	G	A			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr17:26951278G>A	ENST00000528896.2	-	25	4799	c.4725C>T	c.(4723-4725)aaC>aaT	p.N1575N	KIAA0100_ENST00000389003.3_Silent_p.N1432N|KIAA0100_ENST00000544884.1_Silent_p.N1432N	NM_014680.3	NP_055495.2	Q14667	K0100_HUMAN	KIAA0100	1575						extracellular region				breast(3)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(13)|lung(23)|ovary(2)|prostate(2)|skin(6)|stomach(2)|urinary_tract(3)	68	Lung NSC(42;0.00431)					CAATAAGGCAGTTTCGGTTGT	0.453000													3	105					0	0	1	0	0
SUFU	51684	broad.mit.edu	37	10	104309804	104309804	+	Missense_Mutation	SNP	C	C	G			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr10:104309804C>G	ENST00000369902.3	+	3	561	c.395C>G	c.(394-396)gCc>gGc	p.A132G	SUFU_ENST00000369899.2_Missense_Mutation_p.A132G|SUFU_ENST00000423559.2_Missense_Mutation_p.A132G	NM_016169.3	NP_057253.2	Q9UMX1	SUFU_HUMAN	suppressor of fused homolog (Drosophila)	132					negative regulation of transcription from RNA polymerase II promoter|proteolysis|skeletal system development	cytoplasm|nucleus	identical protein binding|protein binding|signal transducer activity|transcription corepressor activity|transcription factor binding			breast(2)|central_nervous_system(7)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(2)	24		Colorectal(252;0.207)		Epithelial(162;1.36e-08)|all cancers(201;3.81e-07)|BRCA - Breast invasive adenocarcinoma(275;0.242)		GGGGAGTCTGCCCCACCAACA	0.522000			"""D, F, S"""		medulloblastoma	medulloblastoma			Medulloblastoma, associated with Germline SUFU Mutation				13	36					0	0	1	0	0
ZNF484	83744	broad.mit.edu	37	9	95609134	95609134	+	Silent	SNP	A	A	G			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr9:95609134A>G	ENST00000395505.2	-	3	1919	c.1827T>C	c.(1825-1827)ttT>ttC	p.F609F	ZNF484_ENST00000375495.3_Silent_p.F645F|ANKRD19P_ENST00000473204.1_RNA|ZNF484_ENST00000395506.3_Silent_p.F647F|ZNF484_ENST00000332591.6_Silent_p.F609F	NM_001261459.1|NM_001261460.1	NP_001248388.1|NP_001248389.1	Q5JVG2	ZN484_HUMAN	zinc finger protein 484	645					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|cervix(1)|kidney(8)|large_intestine(10)|lung(10)|prostate(2)	33						ATCTGTCAGTAAAAGCCTTTC	0.423000													4	90					0	0	1	0	0
TRANK1	9881	broad.mit.edu	37	3	36898225	36898225	+	Silent	SNP	A	A	G			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr3:36898225A>G	ENST00000301807.6	-	12	3103	c.1206T>C	c.(1204-1206)taT>taC	p.Y402Y	TRANK1_ENST00000428977.2_Silent_p.Y402Y|TRANK1_ENST00000429976.2_Silent_p.Y952Y	NM_014831.2	NP_055646.2	O15050	TRNK1_HUMAN	tetratricopeptide repeat and ankyrin repeat containing 1	952					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			NS(2)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(18)|lung(20)|ovary(1)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	73						TGTCCTCCACATAGCAGCGAG	0.498000													5	216					0	0	1	0	0
TPP1	1200	broad.mit.edu	37	11	6640071	6640071	+	Silent	SNP	C	C	T			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr11:6640071C>T	ENST00000299427.6	-	3	225	c.165G>A	c.(163-165)caG>caA	p.Q55Q	TPP1_ENST00000533371.1_5'UTR|RP11-732A19.9_ENST00000545572.1_RNA|TPP1_ENST00000534644.1_Intron|TPP1_ENST00000528657.1_3'UTR	NM_000391.3	NP_000382.3	O14773	TPP1_HUMAN	tripeptidyl peptidase I	55					bone resorption|cell death|lipid metabolic process|lysosome organization|nervous system development|neuromuscular process controlling balance|peptide catabolic process|protein catabolic process|proteolysis	lysosome|melanosome|soluble fraction	metal ion binding|peptide binding|protein binding|serine-type endopeptidase activity|tripeptidyl-peptidase activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|lung(9)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;3.45e-09)|BRCA - Breast invasive adenocarcinoma(625;0.131)		CCACATTCTGCTGTCTCAGGG	0.612000													26	60					0	0	1	0	0
TPH2	121278	broad.mit.edu	37	12	72425401	72425401	+	Missense_Mutation	SNP	G	G	T			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr12:72425401G>T	ENST00000333850.3	+	11	1540	c.1399G>T	c.(1399-1401)Gtg>Ttg	p.V467L		NM_173353.3	NP_775489.2	Q8IWU9	TPH2_HUMAN	tryptophan hydroxylase 2	467					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(1)|large_intestine(9)|lung(20)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	41					L-Tryptophan(DB00150)	TGAAAATGTGGTGCAGGACCT	0.418000													4	170					0.000602214	0.000630443	1	1	0
C9orf41	138199	broad.mit.edu	37	9	77599836	77599836	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr9:77599836C>T	ENST00000376834.3	-	7	1267	c.1115G>A	c.(1114-1116)gGa>gAa	p.G372E	C9orf41_ENST00000376837.3_3'UTR|RP11-197P3.4_ENST00000455609.1_RNA	NM_152420.1	NP_689633.1	Q8N4J0	CI041_HUMAN	chromosome 9 open reading frame 41	372										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(5)|ovary(1)|skin(1)|urinary_tract(2)	17						TACCTTGAATCCATACTGCAG	0.368000													3	39					0	0	1	0	0
AGMO	392636	broad.mit.edu	37	7	15430468	15430468	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr7:15430468A>G	ENST00000342526.3	-	7	908	c.739T>C	c.(739-741)Ttt>Ctt	p.F247L		NM_001004320.1	NP_001004320.1	Q6ZNB7	ALKMO_HUMAN	alkylglycerol monooxygenase	247					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding			breast(1)|kidney(1)|large_intestine(6)|liver(1)|lung(30)|prostate(1)|skin(2)	42						TACTTACCAAAAATTTTATCC	0.259000													4	13					0	0	1	0	0
PRG4	10216	broad.mit.edu	37	1	186276981	186276981	+	Silent	SNP	A	A	G			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr1:186276981A>G	ENST00000445192.2	+	7	2175	c.2130A>G	c.(2128-2130)aaA>aaG	p.K710K	PRG4_ENST00000367484.3_Intron|PRG4_ENST00000367486.3_Silent_p.K667K|PRG4_ENST00000367483.4_Silent_p.K669K|PRG4_ENST00000367485.4_Silent_p.K617K	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	710	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						CTACCCCTAAAGGGACTGCTC	0.582000													4	87					0	0	1	0	0
WDR72	256764	broad.mit.edu	37	15	53992051	53992051	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr15:53992051C>T	ENST00000396328.1	-	13	1900	c.1661G>A	c.(1660-1662)cGg>cAg	p.R554Q	WDR72_ENST00000559418.1_Missense_Mutation_p.R564Q|WDR72_ENST00000557913.1_Missense_Mutation_p.R551Q|WDR72_ENST00000360509.5_Missense_Mutation_p.R554Q	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	554										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		AAGGTGCTTCCGGGCATGCAG	0.458000													43	109					0	0	1	0	0
ANKRD52	283373	broad.mit.edu	37	12	56638565	56638565	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr12:56638565C>T	ENST00000267116.7	-	24	2714	c.2593G>A	c.(2593-2595)Gct>Act	p.A865T		NM_173595.3	NP_775866.2	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	865							protein binding			endometrium(9)|kidney(2)|large_intestine(8)|lung(6)|ovary(2)|prostate(1)|skin(1)	29						GCGAAGGCAGCGGCGTGAAGG	0.582000													3	63					0	0	1	0	0
TTC26	79989	broad.mit.edu	37	7	138851601	138851601	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr7:138851601C>T	ENST00000464848.1	+	10	991	c.911C>T	c.(910-912)gCt>gTt	p.A304V	TTC26_ENST00000430935.1_Missense_Mutation_p.A304V|TTC26_ENST00000343187.4_Missense_Mutation_p.A273V|TTC26_ENST00000495038.1_Missense_Mutation_p.A173V|TTC26_ENST00000478836.2_Missense_Mutation_p.A197V|TTC26_ENST00000481482.1_3'UTR			A0AVF1	TTC26_HUMAN	tetratricopeptide repeat domain 26	304							binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(3)|lung(7)|ovary(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	24						GTACAAGAAGCTTATAACTTA	0.348000													5	56					0	0	1	0	0
GDAP2	54834	broad.mit.edu	37	1	118426197	118426197	+	Missense_Mutation	SNP	A	A	C			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr1:118426197A>C	ENST00000369443.4	-	11	1409	c.1160T>G	c.(1159-1161)gTa>gGa	p.V387G	GDAP2_ENST00000369442.3_Missense_Mutation_p.V387G|GDAP2_ENST00000464026.1_5'UTR	NM_017686.3	NP_060156.1	Q9NXN4	GDAP2_HUMAN	ganglioside induced differentiation associated protein 2	387	CRAL-TRIO.									kidney(2)|large_intestine(3)|lung(9)|ovary(2)	16		all_cancers(81;0.0156)|all_lung(203;5.81e-05)|Lung NSC(69;0.000446)|all_epithelial(167;0.00295)		Lung(183;0.0583)|LUSC - Lung squamous cell carcinoma(189;0.194)		ATACACTAATACATACTCCTT	0.363000													3	40					0	0	1	0	0
PLA2G4A	5321	broad.mit.edu	37	1	186862236	186862236	+	Missense_Mutation	SNP	T	T	G			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr1:186862236T>G	ENST00000367466.3	+	4	361	c.209T>G	c.(208-210)gTg>gGg	p.V70G	PLA2G4A_ENST00000442353.2_Missense_Mutation_p.V70G|PLA2G4A_ENST00000466600.1_3'UTR	NM_024420.2	NP_077734.1	P47712	PA24A_HUMAN	phospholipase A2, group IVA (cytosolic, calcium-dependent)	70	C2.|Phospholipid binding (Probable).				phospholipid catabolic process|platelet activating factor biosynthetic process|platelet activation	cytosol|endoplasmic reticulum membrane	calcium ion binding|calcium-dependent phospholipid binding|lysophospholipase activity	p.V70E(1)		breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(9)|lung(22)|ovary(1)|prostate(3)|skin(4)|stomach(1)	53					Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Medrysone(DB00253)|Quinacrine(DB01103)	ATAAACCCTGTGTGGAATGAG	0.378000													19	151					0	0	1	0	0
RHAG	6005	broad.mit.edu	37	6	49580195	49580195	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr6:49580195G>A	ENST00000371175.4	-	6	886	c.860C>T	c.(859-861)gCg>gTg	p.A287V	RHAG_ENST00000229810.7_Missense_Mutation_p.A287V	NM_000324.2	NP_000315.2	Q02094	RHAG_HUMAN	Rh-associated glycoprotein	287					carbon dioxide transport|cellular ion homeostasis	integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			NS(1)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(24)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	39	Lung NSC(77;0.0255)					TGCCATATCCGCACAAGTGCC	0.473000													3	70					0	0	1	0	0
IVNS1ABP	10625	broad.mit.edu	37	1	185267218	185267218	+	Nonsense_Mutation	SNP	A	A	C			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr1:185267218A>C	ENST00000367498.3	-	15	2500	c.1878T>G	c.(1876-1878)taT>taG	p.Y626*	IVNS1ABP_ENST00000392007.3_Nonsense_Mutation_p.Y408*|IVNS1ABP_ENST00000459929.1_5'UTR	NM_006469.4	NP_006460.2	Q9Y6Y0	NS1BP_HUMAN	influenza virus NS1A binding protein	626					interspecies interaction between organisms|response to virus|RNA splicing|transcription from RNA polymerase III promoter	cytoplasm|cytoskeleton|spliceosomal complex|transcription factor complex				breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(11)|ovary(4)|prostate(2)	29						ACTCAAGGTTATAGACTTCCA	0.403000													52	99					0	0	1	0	0
STOML3	0	broad.mit.edu	37	13	39541069	39541069	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr13:39541069C>A	ENST00000379631.4	-	7	1113	c.769G>T	c.(769-771)Gcc>Tcc	p.A257S	STOML3_ENST00000423210.1_Missense_Mutation_p.A248S	NM_145286.2	NP_660329.1	Q8TAV4	STML3_HUMAN	stomatin (EPB72)-like 3	257						integral to membrane|plasma membrane				breast(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|skin(1)	11		Lung NSC(96;1.42e-05)|Prostate(109;0.00851)|Breast(139;0.0199)|Lung SC(185;0.0743)		all cancers(112;2.93e-08)|Epithelial(112;3.64e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00107)|BRCA - Breast invasive adenocarcinoma(63;0.00349)|GBM - Glioblastoma multiforme(144;0.0137)		TTCTCGGTGGCTACCGTGCTC	0.493000													4	51					0.00024832	0.000264086	1	1	0
PCDHGA12	0	broad.mit.edu	37	5	140812323	140812323	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr5:140812323A>G	ENST00000252085.3	+	1	2139	c.1997A>G	c.(1996-1998)gAc>gGc	p.D666G	PCDHGB6_ENST00000520790.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA11_ENST00000518882.1_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGA2_ENST00000394576.2_Intron|PCDHGA4_ENST00000571252.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA9_ENST00000573521.1_Intron|PCDHGB4_ENST00000519479.1_Intron|PCDHGA7_ENST00000518325.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA11_ENST00000398587.2_Intron|PCDHGB7_ENST00000398594.2_Intron|PCDHGA8_ENST00000398604.2_Intron|PCDHGA10_ENST00000398610.2_Intron	NM_003735.2|NM_032094.1	NP_003726.1|NP_115265.1														breast(2)|cervix(1)|endometrium(7)|kidney(1)|large_intestine(10)|lung(23)|ovary(5)|pancreas(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(1)	58			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCCGTGGCCGACAGCATCCCC	0.662000													4	115					0	0	1	0	0
OR7C1	26664	broad.mit.edu	37	19	14910064	14910064	+	Silent	SNP	C	C	A	rs147900560		TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr19:14910064C>A	ENST00000248073.2	-	1	959	c.885G>T	c.(883-885)acG>acT	p.T295T	OR7A5_ENST00000601611.1_Intron	NM_198944.1	NP_945182.1	O76099	OR7C1_HUMAN	olfactory receptor, family 7, subfamily C, member 1	295					sensory perception of smell|spermatogenesis	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(2)|ovary(2)|prostate(1)	18						TCTTCATGTCCGTGTTCCTCA	0.522000													3	83					0.00909568	0.00923349	1	1	0
LTF	4057	broad.mit.edu	37	3	46490370	46490370	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr3:46490370C>T	ENST00000231751.4	-	9	1491	c.1196G>A	c.(1195-1197)tGc>tAc	p.C399Y	LTF_ENST00000417439.1_Missense_Mutation_p.C399Y|LTF_ENST00000426532.2_Missense_Mutation_p.C355Y	NM_002343.3	NP_002334.2	P02788	TRFL_HUMAN	lactotransferrin	399	Transferrin-like 2.				cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity			NS(1)|breast(3)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(5)|lung(13)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)	40				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)	CAGGGCGATGCAGTCCTCTGT	0.637000													11	56					0	0	1	0	0
GANC	2595	broad.mit.edu	37	15	42631923	42631923	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr15:42631923C>A	ENST00000318010.8	+	17	2140	c.1900C>A	c.(1900-1902)Cag>Aag	p.Q634K		NM_198141.2	NP_937784.2	Q8TET4	GANC_HUMAN	glucosidase, alpha; neutral C	634					carbohydrate metabolic process		carbohydrate binding|maltose alpha-glucosidase activity			breast(1)|central_nervous_system(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23		all_cancers(109;3.08e-16)|all_epithelial(112;7.48e-15)|Lung NSC(122;3.08e-09)|all_lung(180;1.48e-08)|Melanoma(134;0.0574)|Colorectal(260;0.153)		GBM - Glioblastoma multiforme(94;1.06e-06)		GCGTTGGTACCAGGCTGGAGC	0.567000													3	105					1.23904e-05	1.33896e-05	1	1	0
TGM7	116179	broad.mit.edu	37	15	43579553	43579553	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr15:43579553G>A	ENST00000452443.2	-	6	794	c.790C>T	c.(790-792)Cag>Tag	p.Q264*		NM_052955.2	NP_443187.1	Q96PF1	TGM7_HUMAN	transglutaminase 7	264					peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(8)|lung(16)|ovary(2)|prostate(4)|skin(1)	39		all_cancers(109;2.12e-14)|all_epithelial(112;1.99e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.14e-07)	L-Glutamine(DB00130)	GACCACTGCTGTAGGATGGCC	0.592000													3	61					0	0	1	0	0
CUTA	51596	broad.mit.edu	37	6	33384486	33384486	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr6:33384486G>A	ENST00000488478.1	-	5	516	c.431C>T	c.(430-432)cCt>cTt	p.P144L	CUTA_ENST00000374496.3_Silent_p.L138L|CUTA_ENST00000607266.1_Silent_p.L138L|CUTA_ENST00000494751.1_Intron|CUTA_ENST00000488034.1_Silent_p.L161L|CUTA_ENST00000374500.5_Silent_p.L180L|CUTA_ENST00000440279.3_Silent_p.L138L			O60888	CUTA_HUMAN	cutA divalent cation tolerance homolog (E. coli)	0					protein localization|response to metal ion	membrane	enzyme binding		SLC22A1/CUTA(2)	kidney(1)|lung(3)|urinary_tract(1)	5						ACCCACTGCAGGTACGGAAAG	0.537000													3	58					0	0	1	0	0
PTPRG	5793	broad.mit.edu	37	3	62257083	62257083	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr3:62257083G>A	ENST00000474889.1	+	21	3412	c.3035G>A	c.(3034-3036)cGt>cAt	p.R1012H	PTPRG-AS1_ENST00000495542.1_RNA|PTPRG-AS1_ENST00000479018.1_RNA|PTPRG-AS1_ENST00000474795.1_RNA|PTPRG-AS1_ENST00000462497.1_RNA|PTPRG_ENST00000295874.10_Missense_Mutation_p.R983H|PTPRG-AS1_ENST00000475371.1_RNA	NM_002841.3	NP_002832.3	P23470	PTPRG_HUMAN	protein tyrosine phosphatase, receptor type, G	1012	Tyrosine-protein phosphatase 1.				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	identical protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(12)|liver(2)|lung(15)|ovary(7)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	62				BRCA - Breast invasive adenocarcinoma(55;0.000376)|KIRC - Kidney renal clear cell carcinoma(10;0.0499)|Kidney(10;0.065)		CCCAAGGGTCGTCAGAATGAA	0.468000													6	56					0	0	1	0	0
AC093838.4	0	broad.mit.edu	37	2	132274498	132274498	+	RNA	SNP	C	C	T			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr2:132274498C>T	ENST00000438378.2	+	0	1540					NR_026922.1																						CTTCAGGCAGCGACTCCCAGC	0.632000													3	51					0	0	1	0	0
UBR4	23352	broad.mit.edu	37	1	19481549	19481549	+	Silent	SNP	C	C	T			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr1:19481549C>T	ENST00000375267.2	-	44	6324	c.6321G>A	c.(6319-6321)gcG>gcA	p.A2107A	UBR4_ENST00000375254.3_Silent_p.A2107A|UBR4_ENST00000375217.2_Silent_p.A2107A|UBR4_ENST00000375226.2_Silent_p.A2107A			Q5T4S7	UBR4_HUMAN	ubiquitin protein ligase E3 component n-recognin 4	2107					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			breast(7)|central_nervous_system(1)|cervix(2)|endometrium(23)|kidney(25)|large_intestine(25)|liver(2)|lung(47)|ovary(10)|pancreas(2)|prostate(7)|skin(5)|stomach(5)|upper_aerodigestive_tract(4)|urinary_tract(6)	171		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		CACCACCGCCCGCCACCTGGC	0.483000													10	151					0	0	1	0	0
PIK3CG	5294	broad.mit.edu	37	7	106513199	106513199	+	Silent	SNP	T	T	C			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr7:106513199T>C	ENST00000359195.3	+	4	2413	c.2103T>C	c.(2101-2103)agT>agC	p.S701S	PIK3CG_ENST00000496166.1_Silent_p.S701S|PIK3CG_ENST00000440650.2_Silent_p.S701S	NM_002649.2	NP_002640.2	P48736	PK3CG_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	701					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			breast(7)|central_nervous_system(9)|cervix(1)|endometrium(6)|kidney(4)|large_intestine(16)|liver(4)|lung(59)|ovary(4)|pancreas(4)|prostate(3)|skin(6)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	132						TCTTGAGAAGTGAGATAGCCC	0.448000													23	36					0	0	1	0	0
NETO1	81832	broad.mit.edu	37	18	70423359	70423359	+	Missense_Mutation	SNP	A	A	C			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr18:70423359A>C	ENST00000327305.6	-	8	1549	c.892T>G	c.(892-894)Ttc>Gtc	p.F298V	NETO1_ENST00000299430.2_Missense_Mutation_p.F297V|NETO1_ENST00000583169.1_Missense_Mutation_p.F298V	NM_138966.3	NP_620416.1	Q8TDF5	NETO1_HUMAN	neuropilin (NRP) and tolloid (TLL)-like 1	298	LDL-receptor class A.				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			NS(3)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(36)|ovary(2)|prostate(3)|skin(3)|stomach(1)	63		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		CTATGGCAGAAGAATGTGTTG	0.353000													21	34					0	0	1	0	0
TMEM184B	25829	broad.mit.edu	37	22	38641959	38641959	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr22:38641959C>T	ENST00000361906.3	-	3	548	c.340G>A	c.(340-342)Gtc>Atc	p.V114I	TMEM184B_ENST00000361684.4_Missense_Mutation_p.V114I	NM_001195072.1|NM_012264.4	NP_001182001.1|NP_036396.2	Q9Y519	T184B_HUMAN	transmembrane protein 184B	114						integral to membrane				endometrium(1)|large_intestine(2)|lung(2)|skin(2)|upper_aerodigestive_tract(1)	8	Melanoma(58;0.045)					CAGTCGCGGACGGTGCCGAAG	0.647000													17	22					0	0	1	0	0
SOX8	30812	broad.mit.edu	37	16	1033810	1033810	+	Missense_Mutation	SNP	T	T	G			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr16:1033810T>G	ENST00000293894.3	+	2	620	c.505T>G	c.(505-507)Tac>Gac	p.Y169D		NM_014587.3	NP_055402.2	P57073	SOX8_HUMAN	SRY (sex determining region Y)-box 8	169					adipose tissue development|enteric nervous system development|fat cell differentiation|in utero embryonic development|metanephric nephron tubule formation|morphogenesis of a branching epithelium|negative regulation of apoptosis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|neural crest cell migration|oligodendrocyte differentiation|osteoblast differentiation|peripheral nervous system development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of gliogenesis|positive regulation of osteoblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone levels|renal vesicle induction|retinal rod cell differentiation|Sertoli cell development|signal transduction|spermatogenesis|ureter morphogenesis	cytoplasm|nucleus				central_nervous_system(1)|kidney(1)|lung(5)|prostate(2)|skin(1)	10		Hepatocellular(780;0.00308)				CCACCCCGACTACAAGTACCA	0.682000													3	40					0	0	1	0	0
MUC5B	727897	broad.mit.edu	37	11	1266624	1266624	+	Missense_Mutation	SNP	G	G	T			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr11:1266624G>T	ENST00000447027.1	+	31	8581	c.8523G>T	c.(8521-8523)agG>agT	p.R2841S	RP11-532E4.2_ENST00000532061.2_RNA|MUC5B_ENST00000529681.1_Missense_Mutation_p.R2838S			Q9HC84	MUC5B_HUMAN	mucin 5B, oligomeric mucus/gel-forming	2838	7 X Cys-rich subdomain repeats.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding			cervix(2)|endometrium(36)|kidney(9)|lung(89)|urinary_tract(1)	137		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCACCTCCAGGACCACGGCCA	0.692000													21	41					8.24728e-16	9.20947e-16	1	1	0
SIGLEC16	400709	broad.mit.edu	37	19	50473221	50473221	+	RNA	SNP	T	T	C	rs117072442	by1000genomes	TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr19:50473221T>C	ENST00000602139.1	+	0	222									sialic acid binding Ig-like lectin 16 (gene/pseudogene)									p.W65R(3)		endometrium(2)|kidney(2)|lung(6)	10						GTTCAAAGGATGGACCAGCCC	0.602000													3	49					0	0	1	0	0
HSF5	124535	broad.mit.edu	37	17	56565351	56565351	+	Silent	SNP	G	G	A			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr17:56565351G>A	ENST00000323777.3	-	1	394	c.285C>T	c.(283-285)ggC>ggT	p.G95G		NM_001080439.1	NP_001073908.1	Q4G112	HSF5_HUMAN	heat shock transcription factor family member 5	95						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|ovary(3)|skin(1)	16	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CCCCCGGCCCGCCCAGCACCA	0.682000													3	44					0	0	1	0	0
YEATS2	55689	broad.mit.edu	37	3	183474355	183474355	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr3:183474355G>A	ENST00000305135.5	+	12	1625	c.1430G>A	c.(1429-1431)cGa>cAa	p.R477Q		NM_018023.4	NP_060493.3	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	477					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(24)|ovary(3)|prostate(2)|skin(3)	49	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			CCATTGCCTCGAACCCCGACT	0.433000													13	137					0	0	1	0	0
ZNF563	147837	broad.mit.edu	37	19	12429722	12429722	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr19:12429722T>C	ENST00000293725.5	-	4	1322	c.1117A>G	c.(1117-1119)Acg>Gcg	p.T373A		NM_145276.2	NP_660319.1	Q8TA94	ZN563_HUMAN	zinc finger protein 563	373					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						TGAGATAACGTTTTCCCACAC	0.413000													6	150					0	0	1	0	0
SEPN1	57190	broad.mit.edu	37	1	26135249	26135249	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr1:26135249G>A	ENST00000361547.2	+	5	771	c.716G>A	c.(715-717)cGc>cAc	p.R239H	SEPN1_ENST00000354177.4_Missense_Mutation_p.R205H|SEPN1_ENST00000374315.1_Missense_Mutation_p.R205H	NM_020451.2	NP_065184.2	Q9NZV5	SELN_HUMAN	selenoprotein N, 1	239						endoplasmic reticulum membrane|extracellular region	protein binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(7)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;3.46e-05)|Lung NSC(340;0.00038)|all_lung(284;0.00051)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0505)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0421)|OV - Ovarian serous cystadenocarcinoma(117;1.26e-25)|Colorectal(126;3.01e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000751)|BRCA - Breast invasive adenocarcinoma(304;0.00099)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.0143)|READ - Rectum adenocarcinoma(331;0.0649)		TCCAACAACCGCTTCTATCCA	0.667000													4	145					0	0	1	0	0
AGO2	27161	broad.mit.edu	37	8	141567248	141567248	+	Silent	SNP	G	G	A			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr8:141567248G>A	ENST00000220592.5	-	8	1078	c.966C>T	c.(964-966)taC>taT	p.Y322Y	AGO2_ENST00000519980.1_Silent_p.Y322Y	NM_012154.3	NP_036286.2			argonaute RISC catalytic component 2																		GGAGGTGGGGGTAGCGCAGAA	0.587000													4	184					0	0	1	0	0
RERE	473	broad.mit.edu	37	1	8418294	8418294	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr1:8418294G>A	ENST00000337907.3	-	21	4935	c.4301C>T	c.(4300-4302)tCc>tTc	p.S1434F	RERE_ENST00000377464.1_Missense_Mutation_p.S1166F|RERE_ENST00000400908.2_Missense_Mutation_p.S1434F|RERE_ENST00000400907.2_Intron|RERE_ENST00000476556.1_Missense_Mutation_p.S880F	NM_012102.3	NP_036234.3	Q9P2R6	RERE_HUMAN	arginine-glutamic acid dipeptide (RE) repeats	1434	His-rich.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(5)|liver(1)|lung(16)|ovary(3)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	49	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		gtggaggtgggagtgaatgtg	0.642000													15	12					0	0	1	0	0
SCNN1A	0	broad.mit.edu	37	12	6471351	6471351	+	Silent	SNP	C	C	T			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr12:6471351C>T	ENST00000358945.3	-	3	1181	c.741G>A	c.(739-741)gcG>gcA	p.A247A	SCNN1A_ENST00000540037.1_5'UTR|SCNN1A_ENST00000360168.3_Silent_p.A306A|SCNN1A_ENST00000396966.2_Silent_p.A247A|SCNN1A_ENST00000228916.2_Silent_p.A247A|SCNN1A_ENST00000543768.1_Silent_p.A270A|SCNN1A_ENST00000538979.1_Intron			P37088	SCNNA_HUMAN	sodium channel, non-voltage-gated 1 alpha subunit	247					excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|liver(2)|lung(6)|prostate(1)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	27					Amiloride(DB00594)|Triamterene(DB00384)	ACTCCCTCACCGCATCCACCC	0.567000													11	108					0	0	1	0	0
C7orf31	136895	broad.mit.edu	37	7	25176304	25176304	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr7:25176304G>A	ENST00000409280.1	-	10	1368	c.1060C>T	c.(1060-1062)Cgt>Tgt	p.R354C	C7orf31_ENST00000283905.3_Missense_Mutation_p.R354C			Q8N865	CG031_HUMAN	chromosome 7 open reading frame 31	354										autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(6)|skin(2)|stomach(1)	14						GGACAGGAACGTGGTCTTTGC	0.458000													3	116					0	0	1	0	0
OR51S1	119692	broad.mit.edu	37	11	4869891	4869891	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr11:4869891G>A	ENST00000322101.2	-	1	623	c.548C>T	c.(547-549)aCc>aTc	p.T183I	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron	NM_001004758.1	NP_001004758.1	Q8NGJ8	O51S1_HUMAN	olfactory receptor, family 51, subfamily S, member 1	183					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(15)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		ATAAGAATGGGTTAGGACCTG	0.542000													5	129					0	0	1	0	0
RTKN2	219790	broad.mit.edu	37	10	63959566	63959566	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr10:63959566C>T	ENST00000373789.3	-	11	1337	c.1241G>A	c.(1240-1242)cGg>cAg	p.R414Q	RTKN2_ENST00000395265.1_Missense_Mutation_p.R435Q|RTKN2_ENST00000315289.2_Missense_Mutation_p.R216Q	NM_145307.2	NP_660350.2	Q8IZC4	RTKN2_HUMAN	rhotekin 2	414					signal transduction	intracellular				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(3)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Prostate(12;0.0297)|all_hematologic(501;0.215)					AGGTGGTTTCCGTGGTGACAT	0.378000													21	50					0	0	1	0	0
SYNPO	11346	broad.mit.edu	37	5	150029062	150029062	+	Silent	SNP	A	A	C			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr5:150029062A>C	ENST00000394243.1	+	3	2331	c.1957A>C	c.(1957-1959)Agg>Cgg	p.R653R	SYNPO_ENST00000307662.4_Silent_p.R409R|SYNPO_ENST00000522122.1_Silent_p.R653R|SYNPO_ENST00000519664.1_Silent_p.R409R	NM_001166208.1	NP_001159680.1	Q8N3V7	SYNPO_HUMAN	synaptopodin	653					positive regulation of actin filament bundle assembly|regulation of stress fiber assembly	actin cytoskeleton|cytoplasm|dendritic spine|perikaryon|postsynaptic density|postsynaptic membrane|tight junction	actin binding|protein binding			NS(1)|cervix(1)|endometrium(3)|large_intestine(6)|lung(4)|prostate(1)|urinary_tract(2)	18		Medulloblastoma(196;0.134)|all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCGGCGGCAGAGGGACCAGGG	0.632000													9	18					0	0	1	0	0
NOTCH2	4853	broad.mit.edu	37	1	120611955	120611955	+	Frame_Shift_Del	DEL	G	G	-			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr1:120611955delG	ENST00000256646.2	-	1	285	c.66delC	c.(64-66)ccfs	p.P22fs		NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	22					anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		CACCATGCGCGGGGGCCGCGC	0.756			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome				2	4	---	---	---	---					
DHX15	1665	broad.mit.edu	37	4	24544582	24544582	+	Frame_Shift_Del	DEL	G	G	-			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr4:24544582delG	ENST00000336812.4	-	7	1472	c.1316delC	c.(1315-1317)ctfs	p.P439fs		NM_001358.2	NP_001349.2	O43143	DHX15_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 15	439	Helicase C-terminal.				mRNA processing	U12-type spliceosomal complex	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(5)|liver(1)|lung(6)|ovary(1)|upper_aerodigestive_tract(1)	30		Breast(46;0.0503)				CGCAAATCCAGGATCAATCAC	0.313													17	107	---	---	---	---					
VARS2	57176	broad.mit.edu	37	6	30882973	30882975	+	In_Frame_Del	DEL	TAG	TAG	-			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr6:30882973_30882975delTAG	ENST00000321897.5	+	2	874_876	c.242_244delTAG	c.(241-246)tta>t	p.LV81del	VARS2_ENST00000416670.2_In_Frame_Del_p.LV81del|VARS2_ENST00000542001.1_5'UTR|VARS2_ENST00000541562.1_In_Frame_Del_p.LV111del			Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	81					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(9)|lung(15)|ovary(3)|prostate(3)|skin(4)|urinary_tract(1)	46						CCTAAGGAGTTAGTATTGTATGA	0.468													20	79	---	---	---	---					
AARS	16	broad.mit.edu	37	16	70287871	70287871	+	Frame_Shift_Del	DEL	T	T	-			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr16:70287871delT	ENST00000261772.8	-	18	2614	c.2471delA	c.(2470-2472)agfs	p.K824fs		NM_001605.2	NP_001596.2	P49588	SYAC_HUMAN	alanyl-tRNA synthetase	824					alanyl-tRNA aminoacylation|tRNA processing	cytosol|soluble fraction	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			breast(3)|cervix(2)|endometrium(5)|large_intestine(7)|lung(7)|ovary(1)|pancreas(1)|prostate(1)	27		Ovarian(137;0.0365)		BRCA - Breast invasive adenocarcinoma(221;0.161)	L-Alanine(DB00160)	ATCCATGACCTTCTTTAGGGA	0.552											OREG0023912	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	28	165	---	---	---	---					
RP11-795H16.3	0	broad.mit.edu	37	18	57816806	57816806	+	RNA	DEL	C	C	-			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr18:57816806delC	ENST00000588794.1	+	0	346																											CTGACCAGCACCATGGTGGTG	0.478													2	4	---	---	---	---					
PANK2	80025	broad.mit.edu	37	20	3893120	3893120	+	Frame_Shift_Del	DEL	T	T	-			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr20:3893120delT	ENST00000497424.1	+	4	689	c.378delT	c.(376-378)acfs	p.T126fs	PANK2_ENST00000336066.3_3'UTR|PANK2_ENST00000316562.4_Frame_Shift_Del_p.T417fs	NM_024960.4|NM_153640.2	NP_079236.3|NP_705904.1	Q9BZ23	PANK2_HUMAN	pantothenate kinase 2	417			G -> A (in dbSNP:rs3737084).		cell death|coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial intermembrane space|nucleus	ATP binding|pantothenate kinase activity|protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(5)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15						GAGGAGGAACTTTTTTTGGTC	0.343													8	229	---	---	---	---					
SERHL	94009	broad.mit.edu	37	22	42898666	42898666	+	RNA	DEL	C	C	-			TCGA-G9-7525-01A-31D-2260-08	TCGA-G9-7525-10A-01D-2260-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e92edf41-954e-46d6-b1ec-63e2d070f16f	476829e1-ad0a-4621-9ec5-7e20e881c540	g.chr22:42898666delC	ENST00000359906.2	+	0	409					NR_027786.1				serine hydrolase-like											endometrium(1)|large_intestine(1)	2						CCATATGGTGCCCCCCCCCCA	0.592													2	4	---	---	---	---					
