Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_by_all_platform	validation_method	validation_tumor_sample
PLEKHN1	84069	broad.mit.edu	37	1	909268	909268	+	Missense_Mutation	SNP	C	C	T	rs140958781	byFrequency	TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:909268C>T	uc001ace.2	+	13	1681	c.1646C>T	c.(1645-1647)TCG>TTG	p.S549L	PLEKHN1_uc001acd.2_Missense_Mutation_p.S497L|PLEKHN1_uc001acf.2_Missense_Mutation_p.S462L	NM_032129	NP_115505	Q494U1	PKHN1_HUMAN	pleckstrin homology domain containing, family N	549											0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.00095)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		CCACTCCCCTCGGTGCCTGTG	0.697		NaN											0	0	0	0.104719	0	28	75				
TP73	7161	broad.mit.edu	37	1	3644231	3644231	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:3644231C>T	uc001akp.2	+	8	992	c.882C>T	c.(880-882)ATC>ATT	p.I294I	TP73_uc001akq.2_Silent_p.I294I|TP73_uc010nzj.1_Silent_p.I245I|TP73_uc001akr.2_Silent_p.I245I|TP73_uc009vlk.1_Silent_p.I245I|TP73_uc001aks.2_Silent_p.I245I|TP73_uc010nzk.1_Silent_p.I223I|TP73_uc010nzl.1_5'UTR	NM_005427	NP_005418	O15350	P73_HUMAN	tumor protein p73 isoform a	294	DNA-binding (Potential).				cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mismatch repair|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of JUN kinase activity|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|protein tetramerization|response to gamma radiation|response to X-ray	chromatin|cytosol|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|metal ion binding|p53 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|transcription repressor activity			ovary(1)|lung(1)	2	all_cancers(77;0.0395)|Ovarian(185;0.0634)|Lung NSC(156;0.188)|all_lung(157;0.198)	all_epithelial(116;7.42e-17)|all_lung(118;1.86e-06)|Lung NSC(185;0.000163)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.109)|Ovarian(437;0.127)		Epithelial(90;5.57e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.87e-22)|GBM - Glioblastoma multiforme(42;5.72e-16)|Colorectal(212;2.22e-05)|COAD - Colon adenocarcinoma(227;8.48e-05)|Kidney(185;0.000539)|BRCA - Breast invasive adenocarcinoma(365;0.000868)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.00751)|Lung(427;0.226)		AGGGCCGCATCTGCGCCTGTC	0.672		NaN											0	0	0	0.02938	0	7	14				
TNFRSF8	943	broad.mit.edu	37	1	12202457	12202457	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:12202457G>C	uc001atq.2	+	15	1879	c.1657G>C	c.(1657-1659)GAG>CAG	p.E553Q	TNFRSF8_uc010obc.1_Missense_Mutation_p.E441Q|TNFRSF8_uc001atr.2_Missense_Mutation_p.E90Q|TNFRSF8_uc001ats.2_Missense_Mutation_p.E34Q	NM_001243	NP_001234	P28908	TNR8_HUMAN	tumor necrosis factor receptor superfamily,	553	Cytoplasmic (Potential).				cellular response to mechanical stimulus|negative regulation of cell proliferation|positive regulation of apoptosis|positive regulation of TRAIL biosynthetic process|positive regulation of tumor necrosis factor biosynthetic process	cytoplasm|integral to membrane|plasma membrane				skin(2)|ovary(1)|pancreas(1)|central_nervous_system(1)	5	Ovarian(185;0.249)	Lung NSC(185;8.71e-05)|all_lung(284;9.89e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)		GGAGGAGCTGGAGGCGGACCA	0.652		NaN											0	0	0	0.105934	0	13	31				
SPEN	23013	broad.mit.edu	37	1	16199610	16199610	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:16199610G>A	uc001axk.1	+	2	587	c.383G>A	c.(382-384)CGT>CAT	p.R128H	SPEN_uc010obp.1_5'Flank	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	128	Arg-rich.|By similarity.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CGAGAAGGACGTTATGAGCGG	0.488		NaN											0	0	0	0.076483	0	19	38				
C1orf201	90529	broad.mit.edu	37	1	24706145	24706145	+	Missense_Mutation	SNP	T	T	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:24706145T>A	uc001bjc.2	-	5	595	c.460A>T	c.(460-462)AAT>TAT	p.N154Y	C1orf201_uc001bja.2_Missense_Mutation_p.N107Y|C1orf201_uc001bjb.2_Missense_Mutation_p.N62Y|C1orf201_uc001bjd.2_Missense_Mutation_p.N154Y|C1orf201_uc001bje.1_Missense_Mutation_p.N107Y|C1orf201_uc001bjf.2_Missense_Mutation_p.N22Y			Q5TH74	CA201_HUMAN	RecName: Full=UPF0490 protein C1orf201;	154										ovary(1)|breast(1)	2		Colorectal(325;0.000147)|Renal(390;0.00211)|Lung NSC(340;0.0191)|all_lung(284;0.0251)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.056)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;4.48e-25)|Colorectal(126;7.29e-08)|COAD - Colon adenocarcinoma(152;3.85e-06)|GBM - Glioblastoma multiforme(114;0.000399)|BRCA - Breast invasive adenocarcinoma(304;0.00107)|STAD - Stomach adenocarcinoma(196;0.00151)|KIRC - Kidney renal clear cell carcinoma(1967;0.00393)|READ - Rectum adenocarcinoma(331;0.0672)|Lung(427;0.145)		GTTCTTACATTGTAATAGTTT	0.373		NaN											0	0	0	0.09319	0	11	53				
ARID1A	8289	broad.mit.edu	37	1	27059204	27059204	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:27059204C>T	uc001bmv.1	+	4	2214	c.1841C>T	c.(1840-1842)TCA>TTA	p.S614L	ARID1A_uc001bmt.1_Missense_Mutation_p.S614L|ARID1A_uc001bmu.1_Missense_Mutation_p.S614L|ARID1A_uc001bmw.1_Missense_Mutation_p.S231L	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	614					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CAGGCATCCTCAGCCCCCTCA	0.478		NaN	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.062417	0	17	30		Valid		
PUM1	9698	broad.mit.edu	37	1	31478699	31478699	+	Splice_Site	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:31478699C>T	uc001bsi.1	-	5	833	c.720_splice	c.e5+1	p.F240_splice	PUM1_uc001bsg.1_Intron|PUM1_uc001bsh.1_Splice_Site_p.F240_splice|PUM1_uc001bsj.1_Splice_Site_p.F240_splice|PUM1_uc010oga.1_Intron|PUM1_uc001bsk.1_Splice_Site_p.F276_splice|PUM1_uc010ogb.1_Intron	NM_014676	NP_055491	Q14671	PUM1_HUMAN	pumilio 1 isoform 2						cellular membrane organization|post-Golgi vesicle-mediated transport|regulation of translation	cytosol	RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Colorectal(325;0.0211)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|all_neural(195;0.0381)|Breast(348;0.0848)|Medulloblastoma(700;0.123)		STAD - Stomach adenocarcinoma(196;0.0232)|READ - Rectum adenocarcinoma(331;0.0681)		AGCCAACTTACAAATCCTCCT	0.398		NaN											0	0	0	0.09836	0	33	24				
RNF220	55182	broad.mit.edu	37	1	44878109	44878109	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:44878109C>G	uc001clv.1	+	2	700	c.340C>G	c.(340-342)CAT>GAT	p.H114D	RNF220_uc001clw.1_Missense_Mutation_p.H114D	NM_018150	NP_060620	Q5VTB9	RN220_HUMAN	ring finger protein 220	114					protein autoubiquitination	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						TATGCTGAATCATAGTGGTGT	0.537		NaN											0	0	0	0.139131	0	108	78				
STIL	6491	broad.mit.edu	37	1	47767334	47767334	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:47767334G>A	uc001crc.1	-	5	507	c.352C>T	c.(352-354)CTT>TTT	p.L118F	TAL1_uc001crb.1_Intron|STIL_uc010omn.1_Missense_Mutation_p.L118F|STIL_uc010omo.1_Missense_Mutation_p.L118F|STIL_uc001crd.1_Missense_Mutation_p.L118F|STIL_uc001cre.1_Missense_Mutation_p.L118F|STIL_uc001crg.1_Missense_Mutation_p.L118F	NM_003035	NP_003026	Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus isoform 2	118					cell proliferation|multicellular organismal development	centrosome|cytosol				lung(2)|skin(1)	3		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				TCCCCAGGAAGAGAAGCAGTA	0.388		NaN											0	0	0	0.11911	0	12	14				
INADL	10207	broad.mit.edu	37	1	62330234	62330234	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:62330234C>G	uc001dab.2	+	20	2878	c.2764C>G	c.(2764-2766)CAA>GAA	p.Q922E	INADL_uc009waf.1_Missense_Mutation_p.Q922E|INADL_uc001daa.2_Missense_Mutation_p.Q922E|INADL_uc001dad.3_Missense_Mutation_p.Q619E|INADL_uc001dac.2_RNA	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	922					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						ATCCGAGTCTCAAGAGGCAAG	0.483		NaN											0	0	0	0.139131	0	58	54				
MSH4	4438	broad.mit.edu	37	1	76280741	76280741	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:76280741C>A	uc001dhd.1	+	5	776	c.735C>A	c.(733-735)TTC>TTA	p.F245L		NM_002440	NP_002431	O15457	MSH4_HUMAN	mutS homolog 4	245					chiasma assembly|homologous chromosome segregation|mismatch repair|reciprocal meiotic recombination	synaptonemal complex	ATP binding|DNA-dependent ATPase activity|mismatched DNA binding			lung(3)|ovary(2)	5						GGAAATACTTCAATGAAACAA	0.323		NaN						MMR					1	0	4.68919e-08	0.069234	4.82149e-08	8	34				
ZZZ3	26009	broad.mit.edu	37	1	78031766	78031766	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:78031766C>G	uc001dhq.2	-	14	3043	c.2567G>C	c.(2566-2568)TGT>TCT	p.C856S	ZZZ3_uc001dhr.2_Missense_Mutation_p.C362S|ZZZ3_uc001dhp.2_Missense_Mutation_p.C855S	NM_015534	NP_056349	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	856	ZZ-type.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|large_intestine(1)	5						AAACACTTACCAGTCTGAACA	0.393		NaN											0	0	0	0.184627	0	4	15				
FUBP1	8880	broad.mit.edu	37	1	78428504	78428504	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:78428504G>A	uc001dii.2	-	14	1384	c.1295C>T	c.(1294-1296)ACT>ATT	p.T432I	FUBP1_uc001dih.3_RNA|FUBP1_uc010orm.1_Missense_Mutation_p.T453I	NM_003902	NP_003893	Q96AE4	FUBP1_HUMAN	far upstream element-binding protein	432	KH 4.				transcription from RNA polymerase II promoter	nucleus	protein binding|RNA binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			central_nervous_system(2)|lung(1)	3						CTGTTGTGGAGTGCCACGAAT	0.368		NaN											0	0	0	0.115264	0	3	30				
IFI44L	10964	broad.mit.edu	37	1	79107468	79107468	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:79107468G>A	uc010oro.1	+	9	1512	c.1333G>A	c.(1333-1335)GAG>AAG	p.E445K	IFI44L_uc010orp.1_Missense_Mutation_p.E182K|IFI44L_uc010orq.1_Missense_Mutation_p.E182K	NM_006820	NP_006811	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like	445						cytoplasm					0						AGGTGCAATTGAGAGAGCGTT	0.448		NaN											0	0	0	0.139131	0	44	121				
GBP1	2633	broad.mit.edu	37	1	89522638	89522638	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:89522638C>G	uc001dmx.2	-	7	1274	c.1054G>C	c.(1054-1056)GAG>CAG	p.E352Q		NM_002053	NP_002044	P32455	GBP1_HUMAN	guanylate binding protein 1,	352					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		TCCAGCAGCTCCTGGAGGGTT	0.517		NaN											0	0	0	0.069288	0	18	48				
AMY2B	280	broad.mit.edu	37	1	104116527	104116527	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:104116527C>T	uc001duq.2	+	6	1327	c.711C>T	c.(709-711)TTC>TTT	p.F237F	AMY2B_uc010ouo.1_RNA|LOC648740_uc001dur.2_Silent_p.F237F|AMY2B_uc001dus.1_5'Flank	NM_020978	NP_066188	P19961	AMY2B_HUMAN	amylase, pancreatic, alpha-2B precursor	237					carbohydrate metabolic process|digestion	extracellular region	alpha-amylase activity|metal ion binding				0		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0669)|all cancers(265;0.083)|Epithelial(280;0.094)|Lung(183;0.112)		GTAACTGGTTCCCTGCAGGAA	0.363		NaN											0	0	0	0.139131	0	32	35				
NBPF16	728936	broad.mit.edu	37	1	148754879	148754879	+	Missense_Mutation	SNP	A	A	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:148754879A>T	uc010pba.1	+	14	1726	c.1535A>T	c.(1534-1536)CAG>CTG	p.Q512L	NBPF16_uc009wkt.1_Missense_Mutation_p.Q292L	NM_001102663	NP_001096133			hypothetical protein LOC728936												0	all_hematologic(923;0.032)					GAAGTCTTGCAGGACTCACTG	0.468		NaN											0	0	0	0.115264	0	3	47				
SSR2	6746	broad.mit.edu	37	1	155989830	155989830	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:155989830C>T	uc001fmx.2	-	2	209	c.129G>A	c.(127-129)CAG>CAA	p.Q43Q	SSR2_uc001fmw.2_RNA|SSR2_uc001fmy.2_RNA|SSR2_uc010pgv.1_Silent_p.Q62Q|SSR2_uc010pgw.1_Silent_p.Q62Q	NM_003145	NP_003136	P43308	SSRB_HUMAN	signal sequence receptor, beta precursor	43	Lumenal (Potential).				cotranslational protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	signal sequence binding				0	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)					AGATGTTGTACTGCAAGGTCA	0.473		NaN											0	0	0	0.069234	0	8	65				
KIRREL	55243	broad.mit.edu	37	1	158059548	158059548	+	Silent	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:158059548G>C	uc001frn.3	+	10	1616	c.1212G>C	c.(1210-1212)GTG>GTC	p.V404V	KIRREL_uc010pib.1_Silent_p.V304V|KIRREL_uc009wsq.2_Silent_p.V240V|KIRREL_uc001fro.3_Silent_p.V218V	NM_018240	NP_060710	Q96J84	KIRR1_HUMAN	kin of IRRE like precursor	404	Ig-like C2-type 5.|Extracellular (Potential).					integral to membrane				ovary(1)	1	all_hematologic(112;0.0378)					AGTATGCTGTGAGGGGTGACG	0.602		NaN											0	0	0	0.139131	0	38	211				
DDR2	4921	broad.mit.edu	37	1	162750019	162750019	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:162750019C>A	uc001gcf.2	+	19	3016	c.2551C>A	c.(2551-2553)CAA>AAA	p.Q851K	DDR2_uc001gcg.2_Missense_Mutation_p.Q851K|uc001gch.1_5'Flank	NM_001014796	NP_001014796	Q16832	DDR2_HUMAN	discoidin domain receptor family, member 2	851	Cytoplasmic (Potential).				cell adhesion	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(2)|central_nervous_system(2)|ovary(1)|kidney(1)	6	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.113)			TCTGCTCCTTCAACAAGGCGA	0.527		NaN											1	0	2.68362e-12	0.09319	2.83031e-12	12	93				
ADCY10	55811	broad.mit.edu	37	1	167792259	167792259	+	Silent	SNP	G	G	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:167792259G>T	uc001ger.2	-	29	4453	c.4155C>A	c.(4153-4155)ATC>ATA	p.I1385I	ADCY10_uc009wvj.2_RNA|ADCY10_uc009wvk.2_Silent_p.I1293I|ADCY10_uc010plj.1_Silent_p.I1232I	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	1385					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						AATAAAGCAGGATGTCCAAGC	0.502		NaN											1	0	1.33834e-09	0.189662	1.38916e-09	16	39				
GPR161	23432	broad.mit.edu	37	1	168066120	168066120	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:168066120G>C	uc001gfc.2	-	5	1039	c.725C>G	c.(724-726)TCC>TGC	p.S242C	GPR161_uc001gfb.2_Missense_Mutation_p.S110C|GPR161_uc010pll.1_Missense_Mutation_p.S152C|GPR161_uc010plm.1_Missense_Mutation_p.S128C|GPR161_uc009wvo.2_Missense_Mutation_p.S259C|GPR161_uc001gfd.2_Missense_Mutation_p.S242C|GPR161_uc010pln.1_Missense_Mutation_p.S262C|GPR161_uc001gfe.1_Missense_Mutation_p.S242C	NM_153832	NP_722561	Q8N6U8	GP161_HUMAN	G protein-coupled receptor 161 isoform 2	242	Cytoplasmic (Potential).				multicellular organismal development	integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_hematologic(923;0.215)					GGAGGTGCTGGAGTTCTTCCT	0.602		NaN											0	0	0	0.139131	0	89	106				
RFWD2	64326	broad.mit.edu	37	1	176050418	176050418	+	Missense_Mutation	SNP	T	T	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:176050418T>C	uc001gku.1	-	11	1403	c.1147A>G	c.(1147-1149)AGT>GGT	p.S383G	RFWD2_uc001gkv.1_Missense_Mutation_p.S359G|RFWD2_uc001gkw.1_Missense_Mutation_p.S143G|RFWD2_uc009wwv.2_Missense_Mutation_p.S182G|RFWD2_uc001gkt.1_Missense_Mutation_p.S222G	NM_022457	NP_071902	Q8NHY2	RFWD2_HUMAN	ring finger and WD repeat domain 2 isoform a	383					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0						GCAGTTCGACTGTCATCTATA	0.323		NaN											0	0	0	0.069234	0	9	24				
KIAA1614	57710	broad.mit.edu	37	1	180904553	180904553	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:180904553G>A	uc001gok.2	+	5	1575	c.1508G>A	c.(1507-1509)CGG>CAG	p.R503Q	KIAA1614_uc001gol.1_Missense_Mutation_p.R124Q|KIAA1614_uc001gom.1_Intron	NM_020950	NP_066001	Q5VZ46	K1614_HUMAN	hypothetical protein LOC57710	503										ovary(3)|skin(1)	4						GGGGCTCCCCGGCTCCGGGAC	0.741		NaN											0	0	0	0.021553	0	4	23				
LAMC2	3918	broad.mit.edu	37	1	183208644	183208644	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:183208644G>C	uc001gqa.2	+	20	3329	c.3015G>C	c.(3013-3015)CAG>CAC	p.Q1005H	LAMC2_uc001gpz.3_Missense_Mutation_p.Q1005H|LAMC2_uc010poa.1_Missense_Mutation_p.Q705H	NM_005562	NP_005553	Q13753	LAMC2_HUMAN	laminin, gamma 2 isoform a precursor	1005	Potential.|Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			skin(2)|ovary(1)	3						CTGATGCACAGAGGGCAAAGA	0.537		NaN											0	0	0	0.183431	0	31	78				
LAMC2	3918	broad.mit.edu	37	1	183209259	183209259	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:183209259G>C	uc001gqa.2	+	21	3468	c.3154G>C	c.(3154-3156)GAG>CAG	p.E1052Q	LAMC2_uc001gpz.3_Missense_Mutation_p.E1052Q|LAMC2_uc010poa.1_Missense_Mutation_p.E752Q	NM_005562	NP_005553	Q13753	LAMC2_HUMAN	laminin, gamma 2 isoform a precursor	1052	Potential.|Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly		heparin binding			skin(2)|ovary(1)	3						TCTGAAGAGTGAGATGAGGGA	0.507		NaN											0	0	0	0.055883	0	19	74				
FAM58B	339521	broad.mit.edu	37	1	200183191	200183191	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:200183191G>A	uc009wzi.1	+	1	536	c.500G>A	c.(499-501)CGG>CAG	p.R167Q		NM_001105517	NP_001098987	P0C7Q3	FA58B_HUMAN	family with sequence similarity 58 member B	167					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent		protein kinase binding				0	Prostate(682;0.19)					AGCTGGCAGCGGACCCCCGTT	0.627		NaN											0	0	0	0.173368	0	23	59				
NAV1	89796	broad.mit.edu	37	1	201749566	201749566	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:201749566C>A	uc001gwu.2	+	4	1591	c.1244C>A	c.(1243-1245)TCC>TAC	p.S415Y	NAV1_uc001gwv.1_5'UTR|NAV1_uc001gww.1_Missense_Mutation_p.S24Y|NAV1_uc001gwx.2_Missense_Mutation_p.S24Y|NAV1_uc001gwy.1_5'Flank	NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	415					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4						GAAAGCAGCTCCATCAGTAGT	0.463		NaN											1	0	4.59853e-10	0.108266	4.78831e-10	25	72				
NAV1	89796	broad.mit.edu	37	1	201749603	201749603	+	Silent	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:201749603C>G	uc001gwu.2	+	4	1628	c.1281C>G	c.(1279-1281)CTC>CTG	p.L427L	NAV1_uc001gwv.1_5'UTR|NAV1_uc001gww.1_Silent_p.L36L|NAV1_uc001gwx.2_Silent_p.L36L|NAV1_uc001gwy.1_5'Flank	NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	427					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4						CAGACAATCTCAGTTCAGAAG	0.488		NaN											0	0	0	0.092188	0	32	82				
NAV1	89796	broad.mit.edu	37	1	201749677	201749677	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:201749677C>T	uc001gwu.2	+	4	1702	c.1355C>T	c.(1354-1356)TCA>TTA	p.S452L	NAV1_uc001gwv.1_5'UTR|NAV1_uc001gww.1_Missense_Mutation_p.S61L|NAV1_uc001gwx.2_Missense_Mutation_p.S61L|NAV1_uc001gwy.1_5'Flank	NM_020443	NP_065176	Q8NEY1	NAV1_HUMAN	neuron navigator 1	452					cell differentiation|nervous system development	cytoplasm|microtubule	nucleoside-triphosphatase activity|nucleotide binding			central_nervous_system(3)|ovary(1)	4						CGCAGGAACTCAACAATAGTG	0.498		NaN											0	0	0	0.144211	0	22	74				
SLC30A1	7779	broad.mit.edu	37	1	211751465	211751465	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:211751465G>A	uc001hio.1	-	1	635	c.490C>T	c.(490-492)CGC>TGC	p.R164C		NM_021194	NP_067017	Q9Y6M5	ZNT1_HUMAN	solute carrier family 30 (zinc transporter),	164	Cytoplasmic (Potential).				cadmium ion transmembrane transport|cellular calcium ion homeostasis|cellular zinc ion homeostasis|negative regulation of calcium ion import|negative regulation of neurotransmitter secretion|negative regulation of zinc ion import	integral to membrane|T-tubule	calcium channel inhibitor activity|zinc ion transmembrane transporter activity			ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(81;0.00535)|GBM - Glioblastoma multiforme(131;0.051)|all cancers(67;0.0604)|Epithelial(68;0.0978)		CTCTTAACGCGAGGCCCCTTG	0.701		NaN											0	0	0	0.184627	0	4	16				
KCNK2	3776	broad.mit.edu	37	1	215259881	215259881	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:215259881C>G	uc001hkq.2	+	2	386	c.217C>G	c.(217-219)CTG>GTG	p.L73V	KCNK2_uc001hko.2_Missense_Mutation_p.L69V|KCNK2_uc009xdm.2_RNA|KCNK2_uc001hkp.2_RNA|KCNK2_uc010pua.1_RNA|KCNK2_uc001hkr.3_Missense_Mutation_p.L58V	NM_001017425	NP_001017425	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2 isoform	73	Helical; (Potential).						outward rectifier potassium channel activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	TGTCCTCTATCTGATCATCGG	0.483		NaN											0	0	0	0.189662	0	17	29				
LBR	3930	broad.mit.edu	37	1	225598067	225598067	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:225598067C>T	uc001hoy.2	-	10	1383	c.1240G>A	c.(1240-1242)GCT>ACT	p.A414T	LBR_uc001hoz.2_Missense_Mutation_p.A414T|LBR_uc001hpa.1_Missense_Mutation_p.A414T	NM_002296	NP_002287	Q14739	LBR_HUMAN	lamin B receptor	414					cholesterol biosynthetic process	integral to nuclear inner membrane	chromo shadow domain binding|delta14-sterol reductase activity|DNA binding|lamin binding|receptor activity			ovary(1)|skin(1)	2	Breast(184;0.165)			GBM - Glioblastoma multiforme(131;0.117)		GATGGAACAGCGCGGTCCTGT	0.358		NaN											0	0	0	0.069288	0	16	69				
LYST	1130	broad.mit.edu	37	1	235973651	235973651	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:235973651C>G	uc001hxj.2	-	5	642	c.467G>C	c.(466-468)AGA>ACA	p.R156T	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_Missense_Mutation_p.R156T	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	156					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TCTTGCATCTCTTACAGAATA	0.418		NaN							Chediak-Higashi_syndrome				0	0	0	0.193644	0	30	42				
FMN2	56776	broad.mit.edu	37	1	240255687	240255687	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:240255687C>T	uc010pyd.1	+	1	503	c.278C>T	c.(277-279)TCC>TTC	p.S93F	FMN2_uc010pye.1_Missense_Mutation_p.S93F	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	93					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GCCGGCGGCTCCCGCGAAGAT	0.617		NaN											0	0	0	0.069234	0	9	27				
FMN2	56776	broad.mit.edu	37	1	240255999	240255999	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:240255999C>G	uc010pyd.1	+	1	815	c.590C>G	c.(589-591)TCA>TGA	p.S197*	FMN2_uc010pye.1_Nonsense_Mutation_p.S197*	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	197	Potential.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			GATTTGCTTTCAGACATCCAG	0.413		NaN											0	0	0	0.038147	0	7	38				
TUBB8	347688	broad.mit.edu	37	10	93872	93872	+	Missense_Mutation	SNP	T	T	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:93872T>G	uc001ifi.2	-	4	460	c.460A>C	c.(460-462)AAG>CAG	p.K154Q	TUBB8_uc009xhe.2_Missense_Mutation_p.K117Q|TUBB8_uc010pzs.1_Missense_Mutation_p.K82Q	NM_177987	NP_817124	Q3ZCM7	TBB8_HUMAN	tubulin, beta 8 isoform 1	154					microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1		all_cancers(4;0.00131)|all_lung(4;0.000777)|Lung NSC(4;0.0043)|all_epithelial(10;0.0154)|Colorectal(49;0.235)		Epithelial(11;0.00341)|all cancers(11;0.00922)|OV - Ovarian serous cystadenocarcinoma(14;0.0508)|Lung(33;0.132)		TCCCGGATCTTACTGAGCAGA	0.602		NaN											0	0	0	0.175082	0	15	250				
PFKFB3	5209	broad.mit.edu	37	10	6261552	6261552	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:6261552G>A	uc001ije.2	+	7	903	c.519G>A	c.(517-519)CCG>CCA	p.P173P	PFKFB3_uc001ijd.2_Silent_p.P153P|PFKFB3_uc009xii.2_RNA|PFKFB3_uc010qaw.1_Silent_p.P187P|PFKFB3_uc001ijf.2_Silent_p.P173P	NM_004566	NP_004557	Q16875	F263_HUMAN	6-phosphofructo-2-kinase/fructose-2,	173	6-phosphofructo-2-kinase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding	p.P173P(1)		ovary(2)|central_nervous_system(1)	3						TCTCCAGCCCGGATTACAAAG	0.507		NaN											0	0	0	0.184627	0	5	110				
CUBN	8029	broad.mit.edu	37	10	17153011	17153011	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:17153011C>T	uc001ioo.2	-	9	974	c.922G>A	c.(922-924)GAA>AAA	p.E308K		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	308	EGF-like 4; calcium-binding (Potential).				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	ATCTCACATTCATTGATATCT	0.413		NaN											0	0	0	0.146539	0	14	70				
NSUN6	221078	broad.mit.edu	37	10	18905124	18905124	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:18905124G>A	uc010qcp.1	-	4	828	c.410C>T	c.(409-411)TCA>TTA	p.S137L		NM_182543	NP_872349	Q8TEA1	NSUN6_HUMAN	NOL1/NOP2/Sun domain family, member 6	137	PUA.						methyltransferase activity|RNA binding			ovary(2)	2						TTGTGATGCTGACACAATTCC	0.343		NaN											0	0	0	0.139131	0	39	10				
NEBL	10529	broad.mit.edu	37	10	21102872	21102872	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:21102872G>C	uc001iqi.2	-	23	2739	c.2342C>G	c.(2341-2343)TCA>TGA	p.S781*	NEBL_uc001iqj.2_RNA|NEBL_uc001iqk.2_Intron	NM_006393	NP_006384	O76041	NEBL_HUMAN	nebulette sarcomeric isoform	781	Nebulin 22.				regulation of actin filament length		actin binding|structural constituent of muscle			ovary(2)	2						CCCTACCATTGAAATATGATT	0.383		NaN											0	0	0	0.105934	0	9	29				
RASGEF1A	221002	broad.mit.edu	37	10	43696157	43696157	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:43696157G>A	uc001jap.1	-	5	720	c.639C>T	c.(637-639)TGC>TGT	p.C213C	RASGEF1A_uc001jao.1_Silent_p.C221C	NM_145313	NP_660356	Q8N9B8	RGF1A_HUMAN	RasGEF domain family, member 1A	213					cell migration|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity				0						CCAGGGGGTCGCAGCACACGC	0.642		NaN											0	0	0	0.021553	0	5	54				
ZNF32	7580	broad.mit.edu	37	10	44140096	44140096	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:44140096C>G	uc001jbb.2	-	3	413	c.224G>C	c.(223-225)AGG>ACG	p.R75T	uc001jba.2_Intron|ZNF32_uc001jbc.2_Missense_Mutation_p.R75T	NM_001005368	NP_001005368	P17041	ZNF32_HUMAN	zinc finger protein 32	75					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1		all_neural(218;0.0182)|Ovarian(717;0.0443)|Renal(717;0.157)		Lung(62;0.179)		CTCATAGACCCTTTGTCTCAC	0.448		NaN											0	0	0	0.139131	0	37	23				
PAPSS2	9060	broad.mit.edu	37	10	89504908	89504908	+	Silent	SNP	C	C	T	rs7918595		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:89504908C>T	uc001kex.2	+	11	1889	c.1626C>T	c.(1624-1626)CTC>CTT	p.L542L	PAPSS2_uc001kew.2_Silent_p.L547L	NM_004670	NP_004661	O95340	PAPS2_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase 2	542	Adenylyl-sulfate kinase.				3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|protein binding|sulfate adenylyltransferase (ATP) activity			central_nervous_system(1)|skin(1)	2		Melanoma(5;0.019)|Colorectal(252;0.123)		UCEC - Uterine corpus endometrioid carcinoma (6;0.00164)|Colorectal(12;0.000323)|COAD - Colon adenocarcinoma(12;0.00124)		CCCCTGGCCTCACCTCTGTGG	0.512		NaN											0	0	0	0.189662	0	16	4				
ACTA2	59	broad.mit.edu	37	10	90695108	90695108	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:90695108C>T	uc001kfp.2	-	9	1122	c.1006G>A	c.(1006-1008)GAG>AAG	p.E336K	STAMBPL1_uc010qmx.1_Intron|ACTA2_uc010qmy.1_Missense_Mutation_p.E291K|ACTA2_uc001kfq.2_Missense_Mutation_p.E336K|uc001kfo.1_RNA	NM_001613	NP_001604	P62736	ACTA_HUMAN	alpha 2 actin	336					response to virus	cytosol	ATP binding				0		Colorectal(252;0.0161)		Colorectal(12;0.000123)|COAD - Colon adenocarcinoma(12;0.00018)		TATTTGCGCTCCGGAGGGGCA	0.507		NaN									OREG0020356	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.139131	0	56	16				
CUTC	51076	broad.mit.edu	37	10	101503808	101503808	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:101503808C>G	uc001kqd.3	+	5	566	c.418C>G	c.(418-420)CTG>GTG	p.L140V	CUTC_uc010qpk.1_Missense_Mutation_p.L140V|CUTC_uc001kqe.3_RNA	NM_015960	NP_057044	Q9NTM9	CUTC_HUMAN	cutC copper transporter homolog	140					copper ion homeostasis|copper ion transport|protein tetramerization	cytoplasm|nucleus	copper ion binding			breast(1)	1		Colorectal(252;0.234)		Epithelial(162;3e-10)|all cancers(201;2.37e-08)		TTGCCGCCCTCTGCCAGTCAC	0.348		NaN											0	0	0	0.214465	0	23	9				
GFRA1	2674	broad.mit.edu	37	10	118030457	118030457	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr10:118030457C>G	uc001lcj.2	-	3	909	c.211G>C	c.(211-213)GAG>CAG	p.E71Q	GFRA1_uc001lci.2_Missense_Mutation_p.E71Q|GFRA1_uc009xyr.2_Missense_Mutation_p.E71Q	NM_005264	NP_005255	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1 isoform a	71	1.				axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			ovary(1)|pancreas(1)	2		Lung NSC(174;0.21)		all cancers(201;0.0337)		CTGCGGCACTCATCCTTGGCC	0.607		NaN											0	0	0	0.086207	0	33	49				
ANO9	338440	broad.mit.edu	37	11	418436	418436	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:418436G>A	uc001lpi.2	-	23	2369	c.2284C>T	c.(2284-2286)CGG>TGG	p.R762W	SIGIRR_uc001lpf.2_5'Flank|SIGIRR_uc001lpe.1_5'Flank|ANO9_uc001lph.2_Missense_Mutation_p.R455W|ANO9_uc010qvv.1_Missense_Mutation_p.R618W	NM_001012302	NP_001012302	A1A5B4	ANO9_HUMAN	tumor protein p53 inducible protein 5	762	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			central_nervous_system(2)|ovary(1)|skin(1)	4						ATTGGGGGCCGAGAGCCTGCC	0.627		NaN											0	0	0	0.132662	0	14	28				
TSPAN4	7106	broad.mit.edu	37	11	862710	862710	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:862710C>T	uc001lsd.1	+	4	433	c.224C>T	c.(223-225)GCC>GTC	p.A75V	TSPAN4_uc001lse.1_Missense_Mutation_p.A11V|TSPAN4_uc001lsf.1_Missense_Mutation_p.A75V|TSPAN4_uc001lsg.1_Missense_Mutation_p.A75V|TSPAN4_uc001lsh.1_Missense_Mutation_p.A75V|TSPAN4_uc001lsi.1_Missense_Mutation_p.A75V|TSPAN4_uc001lsj.1_Missense_Mutation_p.A75V	NM_003271	NP_003262	O14817	TSN4_HUMAN	tetraspanin 4 isoform a	75	Helical; (Potential).				protein complex assembly	integral to plasma membrane				breast(1)	1		all_cancers(49;2.64e-08)|all_epithelial(84;4.17e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)|all_lung(207;0.24)		all cancers(45;4.32e-25)|Epithelial(43;3.29e-24)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TGCCTGGGTGCCATCAAGGAG	0.667		NaN											0	0	0	0.080935	0	8	22				
OR52W1	120787	broad.mit.edu	37	11	6220474	6220474	+	Silent	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:6220474C>G	uc010qzz.1	+	1	21	c.21C>G	c.(19-21)CTC>CTG	p.L7L		NM_001005178	NP_001005178	Q6IF63	O52W1_HUMAN	olfactory receptor, family 52, subfamily W,	7	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;2.13e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTCTACAACTCAATTCCACCT	0.517		NaN											0	0	0	0.214465	0	34	43				
TSG101	7251	broad.mit.edu	37	11	18503374	18503374	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:18503374C>A	uc001mor.2	-	9	1012	c.886G>T	c.(886-888)GAA>TAA	p.E296*		NM_006292	NP_006283	Q99816	TS101_HUMAN	tumor susceptibility gene 101	296	Potential.				cell division|cellular membrane organization|endosome transport|interspecies interaction between organisms|non-lytic virus budding|protein transport|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	early endosome|late endosome membrane|multivesicular body|nucleolus|plasma membrane	calcium-dependent protein binding|DNA binding|transcription corepressor activity|ubiquitin binding|ubiquitin protein ligase binding				0						CTGAGTTCTTCATCCTTCTTT	0.358		NaN											1	0	2.17888e-05	0.058154	2.21948e-05	10	13				
API5	8539	broad.mit.edu	37	11	43333683	43333683	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:43333683G>A	uc010rfh.1	+	1	179	c.6G>A	c.(4-6)CCG>CCA	p.P2P	API5_uc010rfg.1_5'UTR|API5_uc001mxf.2_Silent_p.P2P|API5_uc010rfi.1_Silent_p.P2P	NM_001142930	NP_001136402	Q9BZZ5	API5_HUMAN	apoptosis inhibitor 5 isoform a	2		Not acetylated.			anti-apoptosis|apoptosis	cytoplasm|spliceosomal complex	fibroblast growth factor binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3						TCACCATGCCGACAGTAGAGG	0.647		NaN									OREG0020900	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.139131	0	42	35				
TCN1	6947	broad.mit.edu	37	11	59630175	59630175	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:59630175C>G	uc001noj.2	-	3	378	c.280G>C	c.(280-282)GAG>CAG	p.E94Q		NM_001062	NP_001053	P20061	TCO1_HUMAN	transcobalamin I precursor	94					cobalamin metabolic process|cobalamin transport|cobalt ion transport	extracellular region	cobalamin binding			ovary(2)	2		all_epithelial(135;0.198)			Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AAGGCAAGCTCTCCCGAGCTT	0.383		NaN											0	0	0	0.055883	0	15	26				
KRTAP5-11	440051	broad.mit.edu	37	11	71293573	71293573	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:71293573G>C	uc001oqu.2	-	1	349	c.311C>G	c.(310-312)TCC>TGC	p.S104C		NM_001005405	NP_001005405	Q6L8G4	KR511_HUMAN	keratin associated protein 5-11	104	6 X 4 AA repeats of C-C-X-P.					keratin filament					0						ggagcagctggactggcagca	0.179		NaN											0	0	0	0.139131	0	65	149				
NAALAD2	10003	broad.mit.edu	37	11	89914805	89914805	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:89914805G>A	uc001pdf.3	+	17	1985	c.1876G>A	c.(1876-1878)GTG>ATG	p.V626M	NAALAD2_uc009yvx.2_Missense_Mutation_p.V593M|NAALAD2_uc009yvy.2_Intron	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	626	Extracellular (Potential).				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				ATTTTCTGCTGTGAAAAACTT	0.318		NaN											0	0	0	0.184627	0	3	10				
NAALAD2	10003	broad.mit.edu	37	11	89924900	89924900	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:89924900G>A	uc001pdf.3	+	19	2317	c.2208G>A	c.(2206-2208)CTG>CTA	p.L736L	NAALAD2_uc009yvx.2_Silent_p.L703L|NAALAD2_uc009yvy.2_3'UTR	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	736	Extracellular (Potential).				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				CAGGAACTCTGAAAGAAGTAT	0.368		NaN											0	0	0	0.038147	0	6	17				
IL10RA	3587	broad.mit.edu	37	11	117869673	117869673	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:117869673G>A	uc001prv.2	+	7	1131	c.1054G>A	c.(1054-1056)GAG>AAG	p.E352K	IL10RA_uc010rxl.1_Missense_Mutation_p.E332K|IL10RA_uc010rxm.1_Missense_Mutation_p.E332K|IL10RA_uc010rxn.1_Missense_Mutation_p.E203K|IL10RA_uc001prw.2_Missense_Mutation_p.E203K	NM_001558	NP_001549	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha precursor	352	Cytoplasmic (Potential).					integral to membrane|plasma membrane	interleukin-10 receptor activity			ovary(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		GGGAAACAGGGAGCCCCCTGT	0.647		NaN											0	0	0	0.108266	0	19	29				
GNB3	2784	broad.mit.edu	37	12	6954874	6954874	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:6954874C>G	uc001qrd.2	+	10	1229	c.824C>G	c.(823-825)TCC>TGC	p.S275C	GNB3_uc001qrc.2_Missense_Mutation_p.S231C|GNB3_uc009zfe.2_Missense_Mutation_p.S274C|CDCA3_uc001qre.2_3'UTR|uc001qrf.1_RNA	NM_002075	NP_002066	P16520	GBB3_HUMAN	guanine nucleotide-binding protein, beta-3	275	WD 6.				cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of blood pressure|synaptic transmission	plasma membrane	GTPase activity|GTPase binding|signal transducer activity				0						GGCATCACGTCCGTGGCCTTC	0.597		NaN											0	0	0	0.139131	0	149	237				
CDCA3	83461	broad.mit.edu	37	12	6959647	6959647	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:6959647C>T	uc001qrg.2	-	3	362	c.234G>A	c.(232-234)ATG>ATA	p.M78I	CDCA3_uc001qre.2_Missense_Mutation_p.M78I|uc001qrf.1_5'Flank|USP5_uc001qri.3_5'Flank|USP5_uc001qrh.3_5'Flank	NM_031299	NP_112589	Q99618	CDCA3_HUMAN	cell division cycle associated 3	78					cell division|mitosis	cytosol					0						TGCTGGTCTTCATAGGTGTCC	0.542		NaN											0	0	0	0.139131	0	96	117				
ATF7IP	55729	broad.mit.edu	37	12	14633975	14633975	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:14633975C>T	uc001rbw.2	+	13	3294	c.3136C>T	c.(3136-3138)CAG>TAG	p.Q1046*	ATF7IP_uc001rbv.1_Nonsense_Mutation_p.Q1045*|ATF7IP_uc001rbx.2_Nonsense_Mutation_p.Q1045*|ATF7IP_uc001rby.3_Nonsense_Mutation_p.Q1046*|ATF7IP_uc001rca.2_Nonsense_Mutation_p.Q1046*	NM_018179	NP_060649	Q6VMQ6	MCAF1_HUMAN	activating transcription factor 7 interacting	1046					DNA methylation|interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|regulation of RNA polymerase II transcriptional preinitiation complex assembly|transcription, DNA-dependent		protein binding			lung(3)|ovary(1)|skin(1)	5						TCCAGTAACTCAGGTGACCAC	0.453		NaN											0	0	0	0.139131	0	37	40				
YAF2	10138	broad.mit.edu	37	12	42554413	42554413	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:42554413G>A	uc001rmv.2	-	4	589	c.521C>T	c.(520-522)TCA>TTA	p.S174L	YAF2_uc001rmw.2_Missense_Mutation_p.S198L|YAF2_uc010sko.1_Missense_Mutation_p.S165L|YAF2_uc010skp.1_Missense_Mutation_p.S132L	NM_005748	NP_005739	Q8IY57	YAF2_HUMAN	YY1 associated factor 2	174					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription coactivator activity|transcription corepressor activity|zinc ion binding				0	all_cancers(12;0.000425)	Lung NSC(34;0.0402)|all_lung(34;0.057)		GBM - Glioblastoma multiforme(48;0.0514)		TCCATTCAATGATGAGGCTTC	0.423		NaN											0	0	0	0.058154	0	8	6				
KRT6C	286887	broad.mit.edu	37	12	52865005	52865006	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:52865005_52865006GG>TT	uc001sal.3	-	5	1035_1036	c.987_988CC>AA	c.(985-990)GACCTG>GAAATG	p.329_330DL>EM		NM_173086	NP_775109	P48668	K2C6C_HUMAN	keratin 6C	329_330	Rod.|Linker 12.				cytoskeleton organization	keratin filament	structural molecule activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.0828)		ATGCTGTCCAGGTCCAGGTTGC	0.559		NaN											0	0	0	0.115264	0	75	107				
PAN2	9924	broad.mit.edu	37	12	56718262	56718262	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:56718262G>A	uc001skx.2	-	12	2117	c.1744C>T	c.(1744-1746)CGG>TGG	p.R582W	PAN2_uc001skw.2_5'Flank|PAN2_uc001skz.2_Missense_Mutation_p.R582W|PAN2_uc001sky.2_Missense_Mutation_p.R582W	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	582					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						CGGAATGCCCGAAGAAAATTA	0.498		NaN											0	0	0	0.058154	0	10	5				
HAL	3034	broad.mit.edu	37	12	96368046	96368046	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:96368046C>T	uc001tem.1	-	21	2235	c.1938G>A	c.(1936-1938)AAG>AAA	p.K646K	HAL_uc009zti.1_RNA|HAL_uc010suw.1_Silent_p.K438K|HAL_uc010sux.1_3'UTR	NM_002108	NP_002099	P42357	HUTH_HUMAN	histidine ammonia-lyase	646					biosynthetic process|histidine catabolic process	cytosol	histidine ammonia-lyase activity			ovary(2)|skin(1)	3					L-Histidine(DB00117)	TGGTGGATTTCTTGTGCAGAA	0.438		NaN											0	0	0	0.069288	0	20	61				
ASCL1	429	broad.mit.edu	37	12	103352354	103352354	+	Missense_Mutation	SNP	G	G	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:103352354G>T	uc001tjr.3	+	1	903	c.332G>T	c.(331-333)AGC>ATC	p.S111I		NM_004316	NP_004307	P50553	ASCL1_HUMAN	achaete-scute complex homolog 1	111					cerebral cortex GABAergic interneuron differentiation|negative regulation of apoptosis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|noradrenergic neuron fate commitment|Notch signaling pathway|positive regulation of neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|response to retinoic acid|sympathetic nervous system development	nucleus	bHLH transcription factor binding|E-box binding|sequence-specific DNA binding transcription factor activity|transcription factor binding transcription factor activity				0						TTTGGCTACAGCCTGCCGCAG	0.662		NaN											1	0	7.07596e-05	0.175082	7.16332e-05	15	9				
HSP90B1	7184	broad.mit.edu	37	12	104341191	104341191	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:104341191G>A	uc001tkb.1	+	17	2470	c.2365G>A	c.(2365-2367)GAA>AAA	p.E789K	HSP90B1_uc010swg.1_Missense_Mutation_p.E454K|HSP90B1_uc009zui.1_Silent_p.K325K	NM_003299	NP_003290	P14625	ENPL_HUMAN	heat shock protein 90kDa beta, member 1	789					actin rod assembly|anti-apoptosis|cellular response to ATP|ER-associated protein catabolic process|protein folding|protein transport|regulation of phosphoprotein phosphatase activity|response to hypoxia|sequestering of calcium ion	cytosol|endoplasmic reticulum lumen|endoplasmic reticulum membrane|melanosome|microsome|midbody|perinuclear region of cytoplasm	ATP binding|calcium ion binding|low-density lipoprotein particle receptor binding|protein phosphatase binding|RNA binding|unfolded protein binding|virion binding			ovary(2)|skin(1)	3					Rifabutin(DB00615)	aacagatgaagaagaagaaAC	0.184		NaN											0	0	0	0.105934	0	14	9				
ZNF10	7556	broad.mit.edu	37	12	133732691	133732691	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr12:133732691C>T	uc009zzb.2	+	5	1306	c.859C>T	c.(859-861)CAT>TAT	p.H287Y	ZNF268_uc010tbv.1_Intron|ZNF10_uc001ulq.2_Missense_Mutation_p.H287Y	NM_015394	NP_056209	P21506	ZNF10_HUMAN	zinc finger protein 10	287	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			breast(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;1.28e-06)|all_epithelial(31;0.0051)|Lung NSC(355;0.00948)		OV - Ovarian serous cystadenocarcinoma(86;3.58e-08)|Epithelial(86;6.6e-07)|all cancers(50;2.28e-05)		TCAGCTTATTCATACTGGAGA	0.418		NaN											0	0	0	0.09319	0	9	55				
FREM2	341640	broad.mit.edu	37	13	39438670	39438670	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr13:39438670G>A	uc001uwv.2	+	16	8219	c.7910G>A	c.(7909-7911)TGG>TAG	p.W2637*	FREM2_uc001uww.2_Nonsense_Mutation_p.W723*	NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	2637	Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GCCTGTTTATGGGAGTTCGTT	0.458		NaN											0	0	0	0.062417	0	20	27				
KBTBD6	89890	broad.mit.edu	37	13	41705613	41705613	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr13:41705613C>A	uc001uxu.1	-	1	1324	c.1035G>T	c.(1033-1035)ATG>ATT	p.M345I	KBTBD6_uc010ace.1_Intron|KBTBD6_uc010tfe.1_Missense_Mutation_p.M279I|uc001uxv.1_5'Flank	NM_152903	NP_690867	Q86V97	KBTB6_HUMAN	kelch repeat and BTB (POZ) domain-containing 6	345							protein binding			ovary(1)|skin(1)	2		Lung NSC(96;4.52e-06)|Breast(139;0.00123)|Prostate(109;0.0181)|Lung SC(185;0.0262)|Hepatocellular(98;0.114)		all cancers(112;4.08e-09)|Epithelial(112;4.74e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000131)|GBM - Glioblastoma multiforme(144;0.000876)|BRCA - Breast invasive adenocarcinoma(63;0.0673)		AGAAGATCACCATCTCCTTGG	0.448		NaN											1	0	0.000673444	0.069234	0.000677576	5	63				
KBTBD7	84078	broad.mit.edu	37	13	41767359	41767359	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr13:41767359C>A	uc001uxw.1	-	1	1344	c.1035G>T	c.(1033-1035)ATG>ATT	p.M345I	uc001uxv.1_Intron	NM_032138	NP_115514	Q8WVZ9	KBTB7_HUMAN	kelch repeat and BTB (POZ) domain containing 7	345							protein binding			ovary(1)	1		Lung NSC(96;0.000105)|Breast(139;0.00715)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.21e-09)|Epithelial(112;6.99e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000196)|GBM - Glioblastoma multiforme(144;0.000857)|BRCA - Breast invasive adenocarcinoma(63;0.0669)		AGAAGATCACCATCTCCTTGG	0.428		NaN											1	0	5.03518e-11	0.189662	5.27649e-11	11	13				
SLC25A30	253512	broad.mit.edu	37	13	45973211	45973211	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr13:45973211G>C	uc001vag.2	-	8	754	c.617C>G	c.(616-618)TCA>TGA	p.S206*	SLC25A30_uc010tfs.1_Nonsense_Mutation_p.S131*|SLC25A30_uc001vah.2_Nonsense_Mutation_p.S131*|SLC25A30_uc010tft.1_Nonsense_Mutation_p.S155*|SLC25A30_uc001vaf.2_Nonsense_Mutation_p.S62*	NM_001010875	NP_001010875	Q5SVS4	KMCP1_HUMAN	solute carrier family 25, member 30	206	Helical; Name=5; (Potential).|Solcar 3.				mitochondrial transport	integral to membrane|mitochondrial inner membrane	binding			breast(1)	1		Lung NSC(96;0.00227)|Prostate(109;0.00578)|Breast(56;0.0192)|Lung SC(185;0.0367)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;7.95e-05)		GGTGAAGCTTGAGCTATAAAG	0.463		NaN											0	0	0	0.047766	0	7	34				
ESD	2098	broad.mit.edu	37	13	47365491	47365491	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr13:47365491C>T	uc001vbn.2	-	3	241	c.58G>A	c.(58-60)GAA>AAA	p.E20K	ESD_uc001vbo.2_Missense_Mutation_p.E20K	NM_001984	NP_001975	P10768	ESTD_HUMAN	esterase D/formylglutathione hydrolase	20						cytoplasmic membrane-bounded vesicle	carboxylesterase activity|S-formylglutathione hydrolase activity			ovary(1)	1		all_lung(13;3.54e-08)|Lung NSC(96;9.1e-06)|Breast(56;0.000148)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)		GBM - Glioblastoma multiforme(144;2.66e-05)	Glutathione(DB00143)	CTGTCATGTTCAAAAACTTTC	0.303		NaN											0	0	0	0.189662	0	13	12				
FNDC3A	22862	broad.mit.edu	37	13	49762735	49762735	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr13:49762735G>A	uc001vcm.2	+	17	2215	c.1910G>A	c.(1909-1911)CGA>CAA	p.R637Q	FNDC3A_uc001vcn.2_Missense_Mutation_p.R637Q|FNDC3A_uc001vco.2_RNA|FNDC3A_uc001vcp.1_Missense_Mutation_p.R563Q|FNDC3A_uc001vcq.2_Missense_Mutation_p.R581Q	NM_001079673	NP_001073141	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	637	Fibronectin type-III 4.					Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		TATCGTTTACGAGTTTACTGC	0.413		NaN											0	0	0	0.134883	0	24	157				
EDNRB	1910	broad.mit.edu	37	13	78477333	78477333	+	Silent	SNP	T	T	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr13:78477333T>C	uc001vko.2	-	3	1017	c.759A>G	c.(757-759)CGA>CGG	p.R253R	EDNRB_uc001vkq.1_Silent_p.R253R|uc001vkn.1_Intron|EDNRB_uc010aez.1_Silent_p.R253R|EDNRB_uc001vkp.1_Silent_p.R336R	NM_001122659	NP_001116131	P24530	EDNRB_HUMAN	endothelin receptor type B isoform 1 precursor	253	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|enteric nervous system development|enteric smooth muscle cell differentiation|macrophage chemotaxis|negative regulation of adenylate cyclase activity|negative regulation of cellular protein metabolic process|negative regulation of neuron maturation|negative regulation of transcription from RNA polymerase II promoter|vein smooth muscle contraction	integral to plasma membrane	endothelin-B receptor activity|peptide hormone binding				0		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.037)		GBM - Glioblastoma multiforme(99;0.0933)	Bosentan(DB00559)	GCAAGCAGATTCGCAGATAAC	0.373		NaN											0	0	0	0.163468	0	23	34				
OR4E2	26686	broad.mit.edu	37	14	22134223	22134223	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:22134223G>A	uc010tmd.1	+	1	927	c.927G>A	c.(925-927)ACG>ACA	p.T309T		NM_001001912	NP_001001912	Q8NGC2	OR4E2_HUMAN	olfactory receptor, family 4, subfamily E,	309	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|pancreas(1)|skin(1)	4	all_cancers(95;0.00113)	Acute lymphoblastic leukemia(2;0.0279)		GBM - Glioblastoma multiforme(265;0.0137)		TTTTTTTCACGAAATCATATA	0.393		NaN											0	0	0	0.150653	0	4	11				
SCFD1	23256	broad.mit.edu	37	14	31169416	31169416	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:31169416G>C	uc001wqm.1	+	16	1386	c.1362G>C	c.(1360-1362)ATG>ATC	p.M454I	SCFD1_uc001wqn.1_Missense_Mutation_p.M387I|SCFD1_uc010tpg.1_Missense_Mutation_p.M395I|SCFD1_uc010tph.1_Missense_Mutation_p.M269I|SCFD1_uc010amf.1_Missense_Mutation_p.M269I|SCFD1_uc010tpi.1_Missense_Mutation_p.M362I|SCFD1_uc010amd.1_Missense_Mutation_p.M286I|SCFD1_uc010ame.1_Missense_Mutation_p.M387I	NM_016106	NP_057190	Q8WVM8	SCFD1_HUMAN	vesicle transport-related protein isoform a	454					post-Golgi vesicle-mediated transport|protein transport|regulation of ER to Golgi vesicle-mediated transport|response to toxin|retrograde vesicle-mediated transport, Golgi to ER|vesicle docking involved in exocytosis	cis-Golgi network|endoplasmic reticulum membrane|Golgi cisterna membrane|Golgi-associated vesicle|plasma membrane	syntaxin-5 binding				0	Hepatocellular(127;0.0877)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)	GBM - Glioblastoma multiforme(265;0.0181)		AAGATAAAATGAGGTTGTTTC	0.348		NaN											0	0	0	0.099896	0	20	37				
PTGER2	5732	broad.mit.edu	37	14	52781491	52781491	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:52781491G>A	uc001wzr.2	+	1	476	c.225G>A	c.(223-225)GTG>GTA	p.V75V		NM_000956	NP_000947	P43116	PE2R2_HUMAN	prostaglandin E receptor 2 (subtype EP2), 53kDa	75	Helical; Name=2; (Potential).					integral to plasma membrane	prostaglandin E receptor activity			lung(1)|breast(1)	2	Breast(41;0.0639)|all_epithelial(31;0.0729)				Alprostadil(DB00770)|Iloprost(DB01088)	CCGAGCTGGTGTTCACCGACC	0.711		NaN											0	0	0	0.062417	0	18	60				
SPTB	6710	broad.mit.edu	37	14	65260362	65260362	+	Silent	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:65260362G>C	uc001xht.2	-	13	2073	c.2019C>G	c.(2017-2019)CTC>CTG	p.L673L	SPTB_uc001xhr.2_Silent_p.L673L|SPTB_uc001xhs.2_Silent_p.L673L|SPTB_uc001xhu.2_Silent_p.L673L	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	673	Spectrin 4.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		GCTGTAAGATGAGCACACTGG	0.547		NaN											0	0	0	0.080935	0	11	22				
C14orf174	161394	broad.mit.edu	37	14	77843846	77843846	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:77843846C>T	uc001xtq.1	+	1	85	c.85C>T	c.(85-87)CAT>TAT	p.H29Y	TMED8_uc010ast.1_5'Flank|TMED8_uc001xto.1_5'Flank	NM_001010860	NP_001010860	Q9P1V8	SAM15_HUMAN	hypothetical protein LOC161394	29											0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0278)		GCCTGGACTTCATAAATTGTA	0.517		NaN											0	0	0	0.146539	0	15	21				
FLRT2	23768	broad.mit.edu	37	14	86087957	86087957	+	Silent	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:86087957C>G	uc001xvr.2	+	2	866	c.99C>G	c.(97-99)CTC>CTG	p.L33L	FLRT2_uc010atd.2_Silent_p.L33L	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	33					cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		TGTCCAAACTCCTGGCCTGCC	0.547		NaN											0	0	0	0.139131	0	53	50				
FLRT2	23768	broad.mit.edu	37	14	86088062	86088062	+	Silent	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:86088062C>G	uc001xvr.2	+	2	971	c.204C>G	c.(202-204)CTC>CTG	p.L68L	FLRT2_uc010atd.2_Silent_p.L68L	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	68	Extracellular (Potential).|LRR 1.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		TAACTGTACTCTACCTCCACA	0.517		NaN											0	0	0	0.139131	0	66	49				
FLRT2	23768	broad.mit.edu	37	14	86088862	86088862	+	Missense_Mutation	SNP	G	G	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:86088862G>T	uc001xvr.2	+	2	1771	c.1004G>T	c.(1003-1005)CGG>CTG	p.R335L	FLRT2_uc010atd.2_Missense_Mutation_p.R335L	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	335	Extracellular (Potential).|LRRCT.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		CTCAACGTGCGGGGTTTCATG	0.507		NaN											1	0	4.44732e-65	0.139131	4.78269e-65	87	93				
KCNK13	56659	broad.mit.edu	37	14	90650720	90650720	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:90650720C>G	uc001xye.1	+	2	1042	c.600C>G	c.(598-600)ATC>ATG	p.I200M		NM_022054	NP_071337	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	200	Helical; (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(1)	1		all_cancers(154;0.186)				TCATGCTGATCCTATGCACAG	0.592		NaN											0	0	0	0.09836	0	32	162				
KCNK13	56659	broad.mit.edu	37	14	90650738	90650738	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:90650738C>T	uc001xye.1	+	2	1060	c.618C>T	c.(616-618)ATC>ATT	p.I206I		NM_022054	NP_071337	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	206	Helical; (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(1)	1		all_cancers(154;0.186)				CAGCCTCCATCCTCATCTCTT	0.562		NaN											0	0	0	0.124865	0	34	162				
KCNK13	56659	broad.mit.edu	37	14	90650948	90650948	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:90650948C>G	uc001xye.1	+	2	1270	c.828C>G	c.(826-828)TTC>TTG	p.F276L		NM_022054	NP_071337	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	276	Helical; (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(1)	1		all_cancers(154;0.186)				ACTCCTTGTTCAATGTCATCT	0.522		NaN											0	0	0	0.153744	0	23	78				
KCNK13	56659	broad.mit.edu	37	14	90650969	90650969	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:90650969C>G	uc001xye.1	+	2	1291	c.849C>G	c.(847-849)ATC>ATG	p.I283M		NM_022054	NP_071337	Q9HB14	KCNKD_HUMAN	potassium channel, subfamily K, member 13	283	Helical; (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			skin(1)	1		all_cancers(154;0.186)				CTATCCTCATCAAACAGTCCT	0.517		NaN											0	0	0	0.173368	0	26	94				
GOLGA5	9950	broad.mit.edu	37	14	93299516	93299516	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:93299516G>A	uc001yaz.1	+	10	1951	c.1769G>A	c.(1768-1770)CGA>CAA	p.R590Q	GOLGA5_uc001yba.1_5'UTR	NM_005113	NP_005104	Q8TBA6	GOGA5_HUMAN	Golgi autoantigen, golgin subfamily a, 5	590	Cytoplasmic (Potential).|Potential.				Golgi organization	cis-Golgi network|integral to membrane	ATP binding|protein homodimerization activity|protein tyrosine kinase activity|Rab GTPase binding			ovary(2)|lung(1)	3		all_cancers(154;0.0934)		COAD - Colon adenocarcinoma(157;0.222)		TTAGAAAATCGACTCCATCAG	0.403		NaN	T	RET	papillary thyroid								0	0	0	0.146539	0	12	38				
SLC25A29	123096	broad.mit.edu	37	14	100758860	100758860	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr14:100758860G>A	uc001yha.2	-	4	963	c.672C>T	c.(670-672)GGC>GGT	p.G224G	SLC25A29_uc010avv.2_Silent_p.G158G|SLC25A29_uc010twx.1_Missense_Mutation_p.A202V	NM_001039355	NP_001034444	Q8N8R3	MCATL_HUMAN	solute carrier family 25, member 29	224	Solcar 3.					integral to membrane|mitochondrial inner membrane	binding			ovary(1)	1		Melanoma(154;0.152)			L-Carnitine(DB00583)	AGCGCGGGGCGCCCCGCAGTC	0.706		NaN											0	0	0	0.047766	0	7	19				
CYFIP1	23191	broad.mit.edu	37	15	22955190	22955190	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:22955190C>A	uc001yus.2	+	15	1688	c.1584C>A	c.(1582-1584)TTC>TTA	p.F528L	CYFIP1_uc001yut.2_Missense_Mutation_p.F528L|CYFIP1_uc010aya.1_Missense_Mutation_p.F556L|CYFIP1_uc001yuu.2_5'Flank	NM_014608	NP_055423	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1 isoform	528					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			ovary(4)|pancreas(3)|liver(1)|skin(1)	9		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		ATGAGCCCTTCAATGACCCAG	0.622		NaN											1	0	4.44401e-20	0.117977	4.748e-20	33	49				
RYR3	6263	broad.mit.edu	37	15	33928729	33928729	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:33928729C>T	uc001zhi.2	+	27	3604	c.3534C>T	c.(3532-3534)TTC>TTT	p.F1178F	RYR3_uc010bar.2_Silent_p.F1178F	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1178	B30.2/SPRY 2.|Cytoplasmic (By similarity).|4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AACTTGCCTTCGCTGACTACG	0.493		NaN											0	0	0	0.09319	0	11	54				
RYR3	6263	broad.mit.edu	37	15	33936718	33936718	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:33936718G>C	uc001zhi.2	+	28	3833	c.3763G>C	c.(3763-3765)GAG>CAG	p.E1255Q	RYR3_uc010bar.2_Missense_Mutation_p.E1255Q	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1255	4 X approximate repeats.|B30.2/SPRY 3.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TCCACACATAGAGGTAATGTT	0.512		NaN											0	0	0	0.02938	0	6	13				
RYR3	6263	broad.mit.edu	37	15	34151822	34151822	+	Missense_Mutation	SNP	T	T	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:34151822T>G	uc001zhi.2	+	100	14259	c.14189T>G	c.(14188-14190)ATT>AGT	p.I4730S	RYR3_uc010bar.2_Missense_Mutation_p.I4725S	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	4730	Helical; Name=M9; (Potential).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GGAGGTGGCATTGGTGATGAA	0.423		NaN											0	0	0	0.069234	0	9	29				
CASC5	57082	broad.mit.edu	37	15	40913375	40913375	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:40913375G>A	uc010bbs.1	+	11	1152	c.991G>A	c.(991-993)GAA>AAA	p.E331K	CASC5_uc010ucq.1_Missense_Mutation_p.E155K|CASC5_uc001zme.2_Missense_Mutation_p.E305K|CASC5_uc010bbt.1_Missense_Mutation_p.E305K	NM_170589	NP_733468	Q8NG31	CASC5_HUMAN	cancer susceptibility candidate 5 isoform 1	331	Interaction with BUB1 and BUB1B.				acrosome assembly|attachment of spindle microtubules to kinetochore|cell division|CenH3-containing nucleosome assembly at centromere|mitotic prometaphase|spindle assembly checkpoint	acrosomal vesicle|condensed chromosome kinetochore|cytosol|nucleoplasm	protein binding			breast(3)|central_nervous_system(1)|skin(1)	5		all_cancers(109;2.03e-18)|all_epithelial(112;4.26e-15)|Lung NSC(122;1.12e-10)|all_lung(180;2.59e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;4.99e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0861)|COAD - Colon adenocarcinoma(120;0.211)		CAACTCACGGGAATCTAAAGG	0.378		NaN											0	0	0	0.069234	0	10	26				
INO80	54617	broad.mit.edu	37	15	41365655	41365655	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:41365655C>T	uc001zni.2	-	11	1579	c.1366G>A	c.(1366-1368)GAA>AAA	p.E456K	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	456	Assembles INO80 complex module consisting of conserved components ACTR8, ACTL6A and YY1.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4						TAAGCATTTTCAGCATTCTTC	0.378		NaN											0	0	0	0.069234	0	6	49				
WDR76	79968	broad.mit.edu	37	15	44149340	44149340	+	Missense_Mutation	SNP	A	A	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:44149340A>G	uc001zti.1	+	10	1411	c.1388A>G	c.(1387-1389)TAT>TGT	p.Y463C		NM_024908	NP_079184	Q9H967	WDR76_HUMAN	WD repeat domain 76	463	WD 4.										0		all_cancers(109;3.26e-11)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.61e-06)|all_lung(180;1.5e-05)|Melanoma(134;0.0417)		all cancers(107;3.78e-21)|GBM - Glioblastoma multiforme(94;5.04e-07)		CATAGACAGTATTTTATCACT	0.373		NaN											0	0	0	0.175082	0	12	16				
DUOX2	50506	broad.mit.edu	37	15	45389939	45389939	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:45389939C>T	uc010bea.2	-	28	3769	c.3566G>A	c.(3565-3567)GGT>GAT	p.G1189D	DUOX2_uc001zun.2_Missense_Mutation_p.G1189D	NM_014080	NP_054799	Q9NRD8	DUOX2_HUMAN	dual oxidase 2 precursor	1189	Interaction with TXNDC11 (By similarity).|Helical; (Potential).|Ferric oxidoreductase.				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			ovary(2)|skin(2)|pancreas(1)	5		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		ACCTGTCATACCTGGGGGCAG	0.587		NaN											0	0	0	0.204396	0	16	55				
PLEKHO2	80301	broad.mit.edu	37	15	65157389	65157389	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:65157389G>C	uc002anv.2	+	6	909	c.775G>C	c.(775-777)GAG>CAG	p.E259Q	PLEKHO2_uc010bgz.2_Intron|PLEKHO2_uc002anw.2_Missense_Mutation_p.E209Q	NM_025201	NP_079477	Q8TD55	PKHO2_HUMAN	pleckstrin homology domain containing, family O	259	Pro-rich.									ovary(1)|lung(1)	2						CAGTGGCTCTGAGCAGCCTCC	0.632		NaN											0	0	0	0.144211	0	25	32				
PLEKHO2	80301	broad.mit.edu	37	15	65157595	65157595	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:65157595G>C	uc002anv.2	+	6	1115	c.981G>C	c.(979-981)GAG>GAC	p.E327D	PLEKHO2_uc010bgz.2_Missense_Mutation_p.E3D|PLEKHO2_uc002anw.2_Missense_Mutation_p.E277D	NM_025201	NP_079477	Q8TD55	PKHO2_HUMAN	pleckstrin homology domain containing, family O	327	Pro-rich.									ovary(1)|lung(1)	2						CCATGGGTGAGATGCAGGCTT	0.597		NaN											0	0	0	0.09319	0	8	21				
PLEKHO2	80301	broad.mit.edu	37	15	65157914	65157914	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:65157914G>A	uc002anv.2	+	6	1434	c.1300G>A	c.(1300-1302)GAG>AAG	p.E434K	PLEKHO2_uc010bgz.2_Missense_Mutation_p.E110K|PLEKHO2_uc002anw.2_Missense_Mutation_p.E384K	NM_025201	NP_079477	Q8TD55	PKHO2_HUMAN	pleckstrin homology domain containing, family O	434										ovary(1)|lung(1)	2						GCTGGGCAGTGAGCCGGCCCC	0.602		NaN											0	0	0	0.144211	0	28	21				
RASL12	51285	broad.mit.edu	37	15	65360144	65360144	+	Silent	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:65360144C>G	uc002aoi.1	-	1	245	c.30G>C	c.(28-30)GCG>GCC	p.A10A	RASL12_uc002aoj.1_Silent_p.A10A|RASL12_uc010uir.1_Intron	NM_016563	NP_057647	Q9NYN1	RASLC_HUMAN	RAS-like, family 12 protein	10					small GTPase mediated signal transduction	membrane	GTP binding|GTPase activity			skin(1)	1						GCCCGCTGCCCGCGCGGGGTT	0.766		NaN											0	0	0	0.058154	0	8	11				
BBS4	585	broad.mit.edu	37	15	73007669	73007669	+	Silent	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:73007669C>G	uc002avb.2	+	5	301	c.258C>G	c.(256-258)TCC>TCG	p.S86S	BBS4_uc010ukv.1_Silent_p.S74S|BBS4_uc002avc.2_5'UTR|BBS4_uc002avd.2_Silent_p.S94S	NM_033028	NP_149017	Q96RK4	BBS4_HUMAN	Bardet-Biedl syndrome 4	86	TPR 1.				adult behavior|brain morphogenesis|cell cycle cytokinesis|centrosome organization|cerebral cortex development|convergent extension involved in gastrulation|dendrite development|fat cell differentiation|heart looping|hippocampus development|intracellular transport|maintenance of protein location in nucleus|melanosome transport|microtubule anchoring at centrosome|neural tube closure|nonmotile primary cilium assembly|photoreceptor cell maintenance|pigment granule aggregation in cell center|positive regulation of flagellum assembly|regulation of cilium beat frequency involved in ciliary motility|regulation of cytokinesis|regulation of lipid metabolic process|retina homeostasis|retinal rod cell development|sensory perception of smell|sensory processing|spermatid development|striatum development	BBSome|centriolar satellite|centriole|cilium membrane|microtubule basal body|motile cilium|nonmotile primary cilium|nucleus|pericentriolar material	alpha-tubulin binding|beta-tubulin binding|dynactin binding|microtubule motor activity				0						TCCAAGAATCCCTAGAACTCT	0.443		NaN							Bardet-Biedl_syndrome				0	0	0	0.132662	0	13	26				
RASGRF1	5923	broad.mit.edu	37	15	79284125	79284125	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:79284125C>T	uc002beq.2	-	22	3462	c.3087G>A	c.(3085-3087)GTG>GTA	p.V1029V	RASGRF1_uc002bep.2_Silent_p.V1013V|RASGRF1_uc010blm.1_Silent_p.V938V|RASGRF1_uc002ber.3_Silent_p.V1013V|RASGRF1_uc010unh.1_Silent_p.V424V|RASGRF1_uc002beo.2_Silent_p.V245V	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	1031					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						GCTCAGCCTTCACGCCTTCAG	0.542		NaN											0	0	0	0.047766	0	8	29				
RASGRF1	5923	broad.mit.edu	37	15	79284133	79284133	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:79284133C>T	uc002beq.2	-	22	3454	c.3079G>A	c.(3079-3081)GAA>AAA	p.E1027K	RASGRF1_uc002bep.2_Missense_Mutation_p.E1011K|RASGRF1_uc010blm.1_Missense_Mutation_p.E936K|RASGRF1_uc002ber.3_Missense_Mutation_p.E1011K|RASGRF1_uc010unh.1_Missense_Mutation_p.E422K|RASGRF1_uc002beo.2_Missense_Mutation_p.E243K	NM_002891	NP_002882	Q13972	RGRF1_HUMAN	Ras protein-specific guanine	1029					activation of Rac GTPase activity|apoptosis|induction of apoptosis by extracellular signals|long-term memory|nerve growth factor receptor signaling pathway|neuron projection development|regulation of Rac protein signal transduction|small GTPase mediated signal transduction|synaptic transmission	cytosol|growth cone|plasma membrane|synaptosome	Rho guanyl-nucleotide exchange factor activity			skin(4)|ovary(1)|central_nervous_system(1)	6						TTCACGCCTTCAGCCTGGTTT	0.547		NaN											0	0	0	0.02938	0	6	27				
CPEB1	64506	broad.mit.edu	37	15	83218237	83218237	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr15:83218237C>G	uc002bit.2	-	9	1704	c.1567G>C	c.(1567-1569)GAC>CAC	p.D523H	CPEB1_uc002biq.2_Missense_Mutation_p.D383H|CPEB1_uc002bir.2_Missense_Mutation_p.D388H|CPEB1_uc002bis.2_Missense_Mutation_p.D383H|CPEB1_uc010uod.1_Missense_Mutation_p.D232H|CPEB1_uc010uoe.1_Missense_Mutation_p.D461H|CPEB1_uc002biu.2_Missense_Mutation_p.D485H|CPEB1_uc010uof.1_Missense_Mutation_p.D383H|CPEB1_uc002biv.2_Missense_Mutation_p.D458H|CPEB1_uc002bip.2_Missense_Mutation_p.D232H	NM_001079533	NP_001073001	Q9BZB8	CPEB1_HUMAN	cytoplasmic polyadenylation element binding	463	RRM 2.|Necessary for stress granule assembly and correct localization in dcp1 bodies.				mRNA processing|regulation of translation	cell junction|cytoplasmic mRNA processing body|dendrite|postsynaptic density|postsynaptic membrane	nucleotide binding|RNA binding			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(143;0.229)			TTATCTGTGTCAATCCCGGCA	0.517		NaN											0	0	0	0.062417	0	16	41				
GNPTG	84572	broad.mit.edu	37	16	1413046	1413046	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr16:1413046C>T	uc002clm.2	+	11	907	c.872C>T	c.(871-873)TCT>TTT	p.S291F		NM_032520	NP_115909	Q9UJJ9	GNPTG_HUMAN	N-acetylglucosamine-1-phosphotransferase, gamma	291						extracellular region|Golgi apparatus	protein binding			central_nervous_system(1)	1		Hepatocellular(780;0.0893)				AGAGCCAAGTCTCCAGAGCAG	0.622		NaN											0	0	0	0.09319	0	11	19				
TBL3	10607	broad.mit.edu	37	16	2024268	2024268	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr16:2024268G>A	uc002cnu.1	+	3	266	c.164G>A	c.(163-165)GGG>GAG	p.G55E	TBL3_uc002cnv.1_5'UTR|TBL3_uc010bsb.1_5'Flank|TBL3_uc010bsc.1_5'Flank|TBL3_uc010uvt.1_5'Flank	NM_006453	NP_006444	Q12788	TBL3_HUMAN	transducin beta-like 3	55					G-protein signaling, coupled to cGMP nucleotide second messenger|rRNA processing	nucleolus|small-subunit processome	receptor signaling protein activity				0						GTGGCCTCGGGGGCCGTGCTG	0.647		NaN											0	0	0	0.11126	0	38	83				
DNAH3	55567	broad.mit.edu	37	16	20999096	20999096	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr16:20999096C>T	uc010vbe.1	-	46	6801	c.6801G>A	c.(6799-6801)TCG>TCA	p.S2267S	DNAH3_uc010vbd.1_5'Flank	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2267	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		AATGTGACTTCGAGGGAGTTG	0.493		NaN											0	0	0	0.193644	0	29	12				
EEF2K	29904	broad.mit.edu	37	16	22291646	22291646	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr16:22291646G>A	uc002dki.2	+	17	2502	c.2017G>A	c.(2017-2019)GAG>AAG	p.E673K	EEF2K_uc002dkh.2_RNA	NM_013302	NP_037434	O00418	EF2K_HUMAN	elongation factor-2 kinase	673					insulin receptor signaling pathway|translational elongation	cytosol	ATP binding|calcium ion binding|calmodulin binding|elongation factor-2 kinase activity|translation factor activity, nucleic acid binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(48;0.0223)		CAGGGAGGCCGAGATGCTGTT	0.637		NaN											0	0	0	0.163468	0	28	18				
PRRT2	112476	broad.mit.edu	37	16	29824403	29824403	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr16:29824403G>C	uc002due.3	+	2	329	c.28G>C	c.(28-30)GAG>CAG	p.E10Q	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|uc002duc.1_5'Flank|PRRT2_uc002dud.2_Missense_Mutation_p.E10Q|PRRT2_uc002duf.1_Missense_Mutation_p.E10Q	NM_145239	NP_660282	Q7Z6L0	PRRT2_HUMAN	proline-rich transmembrane protein 2	10	Extracellular (Potential).				response to biotic stimulus	integral to membrane					0						TGAGATCTCTGAGATGAAGGG	0.587		NaN											0	0	0	0.108266	0	24	78				
FTO	79068	broad.mit.edu	37	16	53967927	53967927	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr16:53967927G>C	uc002ehr.2	+	8	1492	c.1270G>C	c.(1270-1272)GAG>CAG	p.E424Q	FTO_uc010vha.1_Missense_Mutation_p.E128Q|FTO_uc010cbz.2_Missense_Mutation_p.E25Q|FTO_uc002ehs.2_RNA	NM_001080432	NP_001073901	Q9C0B1	FTO_HUMAN	fat mass and obesity associated	424					DNA dealkylation involved in DNA repair|oxidative single-stranded DNA demethylation|oxidative single-stranded RNA demethylation|RNA repair	nucleus	DNA-N1-methyladenine dioxygenase activity|ferrous iron binding|oxidative DNA demethylase activity|oxidative RNA demethylase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						AGTTAAAAGAGAGGGGCTCCC	0.418		NaN											0	0	0	0.146539	0	12	25				
GPR97	222487	broad.mit.edu	37	16	57714456	57714456	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr16:57714456C>A	uc002emh.2	+	8	911	c.808C>A	c.(808-810)CGC>AGC	p.R270S	GPR97_uc010vhv.1_Missense_Mutation_p.R150S|GPR97_uc010cdd.2_RNA|GPR97_uc010cde.2_5'UTR	NM_170776	NP_740746	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97 precursor	270	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1						TATCCTCACACGCATCTCCCA	0.577		NaN											1	0	1.96642e-18	0.092188	2.09411e-18	31	86				
KCTD19	146212	broad.mit.edu	37	16	67331452	67331452	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr16:67331452C>T	uc002esu.2	-	7	1152	c.1101G>A	c.(1099-1101)TTG>TTA	p.L367L	KCTD19_uc002est.2_Silent_p.L139L|KCTD19_uc010vjj.1_Silent_p.L110L	NM_001100915	NP_001094385	Q17RG1	KCD19_HUMAN	potassium channel tetramerisation domain	367						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		GATGAGTCTTCAAAGCAACTT	0.493		NaN											0	0	0	0.146539	0	17	30				
RLTPR	146206	broad.mit.edu	37	16	67685194	67685194	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr16:67685194C>T	uc002etn.2	+	23	2409	c.2289C>T	c.(2287-2289)ATC>ATT	p.I763I	RLTPR_uc010cel.1_Silent_p.I756I|RLTPR_uc010vjr.1_Silent_p.I727I|RLTPR_uc010vjs.1_5'Flank	NM_001013838	NP_001013860	Q6F5E8	LR16C_HUMAN	RGD motif, leucine rich repeats, tropomodulin	763										breast(1)	1		Acute lymphoblastic leukemia(13;3.23e-05)|all_hematologic(13;0.00251)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0146)|Epithelial(162;0.0481)|all cancers(182;0.232)		AGGATGCCATCCAAAATGCCA	0.587		NaN											0	0	0	0.139131	0	42	86				
ZNF594	84622	broad.mit.edu	37	17	5086617	5086617	+	Missense_Mutation	SNP	T	T	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:5086617T>C	uc010cla.1	-	2	1091	c.935A>G	c.(934-936)GAA>GGA	p.E312G		NM_032530	NP_115919	Q96JF6	ZN594_HUMAN	zinc finger protein 594	312	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|skin(1)	3						TCTCTGGTGTTCAGTAAGGTG	0.453		NaN											0	0	0	0.069288	0	21	25				
TP53	7157	broad.mit.edu	37	17	7578454	7578454	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:7578454G>A	uc002gim.2	-	5	670	c.476C>T	c.(475-477)GCC>GTC	p.A159V	TP53_uc002gig.1_Missense_Mutation_p.A159V|TP53_uc002gih.2_Missense_Mutation_p.A159V|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.A27V|TP53_uc010cng.1_Missense_Mutation_p.A27V|TP53_uc002gii.1_Missense_Mutation_p.A27V|TP53_uc010cnh.1_Missense_Mutation_p.A159V|TP53_uc010cni.1_Missense_Mutation_p.A159V|TP53_uc002gij.2_Missense_Mutation_p.A159V|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.A66V|TP53_uc002gio.2_Missense_Mutation_p.A27V|TP53_uc010vug.1_Missense_Mutation_p.A120V	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	159	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		A -> G (in sporadic cancers; somatic mutation).|A -> T (in sporadic cancers; somatic mutation).|A -> V (in sporadic cancers; somatic mutation).|A -> P (in sporadic cancers; somatic mutation).|A -> D (in sporadic cancers; somatic mutation).|A -> S (in sporadic cancers; somatic mutation).|A -> F (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.A159V(30)|p.A159P(13)|p.A159A(8)|p.A159T(7)|p.A159D(7)|p.0?(7)|p.A159fs*11(5)|p.A159S(4)|p.R158_A159insX(4)|p.R158_A159delRA(2)|p.R156_I162delRVRAMAI(2)|p.V157fs*9(2)|p.A159fs*21(2)|p.V157_C176del20(1)|p.R156_A161delRVRAMA(1)|p.P151_V173del23(1)|p.R156fs*18(1)|p.R156_A161del(1)|p.R158_A159insXX(1)|p.V157_M160delVRAM(1)|p.S149fs*72(1)|p.T155_A161delTRVRAMA(1)|p.R156fs*20(1)|p.V157_I162delVRAMAI(1)|p.A159_Q167delAMAIYKQSQ(1)|p.V157fs*21(1)|p.R158fs*8(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGCCATGGCGCGGACGCG	0.627		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.139131	0	63	19		Valid		
ODF4	146852	broad.mit.edu	37	17	8248778	8248778	+	Missense_Mutation	SNP	T	T	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:8248778T>C	uc002gle.1	+	2	754	c.572T>C	c.(571-573)ATC>ACC	p.I191T		NM_153007	NP_694552	Q2M2E3	ODFP4_HUMAN	outer dense fiber of sperm tails 4	191	Helical; (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(1)	1						CTGGTGCTTATCCTATACTTC	0.532		NaN											0	0	0	0.139131	0	75	30				
MAP2K3	5606	broad.mit.edu	37	17	21207742	21207742	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:21207742G>A	uc002gys.2	+	8	838	c.573G>A	c.(571-573)GTG>GTA	p.V191V	MAP2K3_uc002gyt.2_Silent_p.V162V|MAP2K3_uc002gyu.2_Silent_p.V162V	NM_145109	NP_659731	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	191	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0				COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		TGGCAGATGTGAAGCCCTCCA	0.577		NaN											0	0	0	0.117977	0	36	95				
KSR1	8844	broad.mit.edu	37	17	25932610	25932610	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:25932610G>C	uc010crg.2	+	15	1865	c.1420G>C	c.(1420-1422)GAG>CAG	p.E474Q	KSR1_uc002gzj.1_RNA|KSR1_uc002gzm.2_Missense_Mutation_p.E253Q	NM_014238	NP_055053	Q8IVT5	KSR1_HUMAN	kinase suppressor of ras	609					Ras protein signal transduction	cytoplasm|membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			lung(3)|central_nervous_system(1)	4	Lung NSC(42;0.00836)		BRCA - Breast invasive adenocarcinoma(3;0.00122)	UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		CATCCCCTTCGAGCAGGTAGA	0.711		NaN											0	0	0	0.115264	0	3	10				
GIT1	28964	broad.mit.edu	37	17	27909075	27909075	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:27909075C>T	uc002hef.2	-	5	707	c.493G>A	c.(493-495)GAG>AAG	p.E165K	GIT1_uc002heg.2_Missense_Mutation_p.E165K|GIT1_uc010wbg.1_Missense_Mutation_p.E165K|GIT1_uc010csb.1_Missense_Mutation_p.E165K	NM_014030	NP_054749	Q9Y2X7	GIT1_HUMAN	G protein-coupled receptor kinase interactor 1	165					regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|focal adhesion	ARF GTPase activator activity|protein binding|zinc ion binding				0				READ - Rectum adenocarcinoma(3;0.0419)|Colorectal(3;0.069)		GTGCCCTTCTCTGGGTGGAAG	0.617		NaN											0	0	0	0.214465	0	36	29				
ACACA	31	broad.mit.edu	37	17	35549207	35549207	+	Missense_Mutation	SNP	G	G	C	rs148729289	byFrequency	TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:35549207G>C	uc002hnm.2	-	37	4320	c.4129C>G	c.(4129-4131)CTG>GTG	p.L1377V	ACACA_uc002hnk.2_Missense_Mutation_p.L1299V|ACACA_uc002hnl.2_Missense_Mutation_p.L1319V|ACACA_uc002hnn.2_Missense_Mutation_p.L1377V|ACACA_uc002hno.2_Missense_Mutation_p.L1414V|ACACA_uc010cuy.2_Missense_Mutation_p.L71V	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	1377					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TGGAAAGCCAGAGCAGGCTCC	0.443		NaN											0	0	0	0.160694	0	14	29				
AFMID	125061	broad.mit.edu	37	17	76201688	76201688	+	Missense_Mutation	SNP	G	G	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:76201688G>T	uc002jva.3	+	9	664	c.649G>T	c.(649-651)GAC>TAC	p.D217Y	AFMID_uc002jvb.3_Intron|AFMID_uc002juz.3_Missense_Mutation_p.D217Y	NM_001010982	NP_001010982	Q63HM1	AFMID_HUMAN	arylformamidase isoform 1	217						cytosol|nucleus	arylformamidase activity			large_intestine(1)|pancreas(1)	2			BRCA - Breast invasive adenocarcinoma(99;0.00269)|OV - Ovarian serous cystadenocarcinoma(97;0.134)			CCCCAGGGAGGACGCTCAGAG	0.672		NaN											1	0	4.63292e-17	0.204396	4.90193e-17	19	57				
DNAH17	8632	broad.mit.edu	37	17	76454708	76454708	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:76454708C>G	uc010dhp.1	-	7	1138	c.916G>C	c.(916-918)GAG>CAG	p.E306Q	DNAH17_uc002jvs.2_RNA					SubName: Full=DNAH17 variant protein; Flags: Fragment;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			TTGATTTTCTCAGCTGTTGCT	0.522		NaN											0	0	0	0.080422	0	33	86				
C1QTNF1	114897	broad.mit.edu	37	17	77043906	77043906	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:77043906C>T	uc002jwp.2	+	4	922	c.582C>T	c.(580-582)TTC>TTT	p.F194F	C1QTNF1_uc002jwq.2_Silent_p.F112F|C1QTNF1_uc002jwr.3_Silent_p.F204F|C1QTNF1_uc002jws.2_Silent_p.F194F|C1QTNF1_uc002jwt.2_Silent_p.F292F	NM_030968	NP_112230	Q9BXJ1	C1QT1_HUMAN	C1q and tumor necrosis factor related protein 1	194	C1q.					collagen				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(99;0.0294)|OV - Ovarian serous cystadenocarcinoma(97;0.201)			GCCTCTACTTCTTCAGCCTCA	0.552		NaN											0	0	0	0.139131	0	82	69				
METRNL	284207	broad.mit.edu	37	17	81043019	81043019	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:81043019G>A	uc002kgh.2	+	2	501	c.376G>A	c.(376-378)GAA>AAA	p.E126K	METRNL_uc002kgi.2_Missense_Mutation_p.E44K	NM_001004431	NP_001004431	Q641Q3	METRL_HUMAN	meteorin, glial cell differentiation	126						extracellular region					0	Breast(20;0.000443)|all_neural(118;0.0779)		BRCA - Breast invasive adenocarcinoma(99;0.0517)|OV - Ovarian serous cystadenocarcinoma(97;0.0868)			AAAAACTGGAGAACTGAGACT	0.637		NaN											0	0	0	0.184627	0	4	66				
PTPRM	5797	broad.mit.edu	37	18	8088834	8088834	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr18:8088834G>C	uc002knn.3	+	11	2344	c.1841G>C	c.(1840-1842)AGA>ACA	p.R614T	PTPRM_uc010dkv.2_Missense_Mutation_p.R614T|PTPRM_uc010wzl.1_Missense_Mutation_p.R401T	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	614	Fibronectin type-III 4.|Extracellular (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				GCCCACAGCAGAGGAGCACCT	0.458		NaN											0	0	0	0.09836	0	38	15				
GNAL	2774	broad.mit.edu	37	18	11868562	11868562	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr18:11868562G>A	uc010dkz.2	+	10	946	c.700G>A	c.(700-702)GTC>ATC	p.V234I	GNAL_uc002kqc.2_Missense_Mutation_p.V311I|GNAL_uc002kqd.2_Missense_Mutation_p.V234I|GNAL_uc010wzt.1_Missense_Mutation_p.V27I	NM_001142339	NP_001135811	P38405	GNAL_HUMAN	guanine nucleotide binding protein (G protein),	234					activation of adenylate cyclase activity by dopamine receptor signaling pathway|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception of smell|synaptic transmission	heterotrimeric G-protein complex	adenylate cyclase activity|G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			ovary(1)	1						TATCATTTACGTCGCAGCCTG	0.463		NaN											0	0	0	0.124865	0	33	79				
DSG1	1828	broad.mit.edu	37	18	28926024	28926024	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr18:28926024G>C	uc002kwp.2	+	14	2175	c.1963G>C	c.(1963-1965)GAA>CAA	p.E655Q	DSG1_uc010xbp.1_Missense_Mutation_p.E14Q	NM_001942	NP_001933	Q02413	DSG1_HUMAN	desmoglein 1 preproprotein	655	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|cell-cell junction assembly|cellular component disassembly involved in apoptosis|homophilic cell adhesion|protein stabilization	cytosol|desmosome|integral to membrane|internal side of plasma membrane	calcium ion binding|gamma-catenin binding|toxin binding			skin(3)|ovary(2)|central_nervous_system(2)	7			OV - Ovarian serous cystadenocarcinoma(10;0.00559)			GACAGGATTTGAACTAACAGA	0.368		NaN											0	0	0	0.047766	0	7	28				
KIAA1468	57614	broad.mit.edu	37	18	59925298	59925298	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr18:59925298G>C	uc002lil.2	+	14	2229	c.2014G>C	c.(2014-2016)GAT>CAT	p.D672H	KIAA1468_uc002lik.1_Missense_Mutation_p.D672H|KIAA1468_uc010xel.1_Missense_Mutation_p.D672H|KIAA1468_uc002lim.2_Missense_Mutation_p.D316H	NM_020854	NP_065905	Q9P260	K1468_HUMAN	hypothetical protein LOC57614	672	HEAT 2.						binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)	6		Colorectal(73;0.186)				GGGATACATTGATGATCCAGA	0.313		NaN											0	0	0	0.038147	0	5	16				
CDH7	1005	broad.mit.edu	37	18	63511079	63511079	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr18:63511079C>T	uc002ljz.2	+	7	1338	c.1013C>T	c.(1012-1014)ACG>ATG	p.T338M	CDH7_uc002lka.2_Missense_Mutation_p.T338M|CDH7_uc002lkb.2_Missense_Mutation_p.T338M	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein	338	Extracellular (Potential).|Cadherin 3.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				ACAAGTTACACGCTACGGATA	0.418		NaN											0	0	0	0.069234	0	11	26				
LMNB2	84823	broad.mit.edu	37	19	2438516	2438516	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:2438516C>T	uc002lvy.2	-	3	442	c.355G>A	c.(355-357)GAG>AAG	p.E119K	LMNB2_uc002lwa.1_Missense_Mutation_p.E139K	NM_032737	NP_116126	Q03252	LMNB2_HUMAN	lamin B2	119	Rod.|Coil 1B.					nuclear inner membrane	structural molecule activity			large_intestine(1)|ovary(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGCTCGCCCTCCCTCTTCTTG	0.662		NaN											0	0	0	0.083992	0	21	13				
PTPRS	5802	broad.mit.edu	37	19	5214591	5214591	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:5214591C>T	uc002mbv.2	-	29	4709	c.4475G>A	c.(4474-4476)CGG>CAG	p.R1492Q	PTPRS_uc002mbu.1_Missense_Mutation_p.R1061Q|PTPRS_uc010xin.1_Missense_Mutation_p.R1034Q|PTPRS_uc002mbw.2_Missense_Mutation_p.R1454Q|PTPRS_uc002mbx.2_Missense_Mutation_p.R1049Q|PTPRS_uc002mby.2_Missense_Mutation_p.R1045Q	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	1492	Cytoplasmic (Potential).|Tyrosine-protein phosphatase 1.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		CTCCTCCAGCCGCGTCATCAT	0.632		NaN											0	0	0	0.204396	0	19	55				
PNPLA6	10908	broad.mit.edu	37	19	7625568	7625568	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:7625568G>A	uc010xjq.1	+	31	3959	c.3764G>A	c.(3763-3765)GGA>GAA	p.G1255E	PNPLA6_uc002mgq.1_Missense_Mutation_p.G1207E|PNPLA6_uc010xjp.1_Missense_Mutation_p.G1180E|PNPLA6_uc002mgr.1_Missense_Mutation_p.G1207E|PNPLA6_uc002mgs.2_Missense_Mutation_p.G1245E|PNPLA6_uc002mgt.1_RNA	NM_006702	NP_006693	Q8IY17	PLPL6_HUMAN	neuropathy target esterase isoform b	1246	Cytoplasmic (Potential).				cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			ovary(3)	3						GCGGTGTTTGGAGGCTGGAGC	0.587		NaN											0	0	0	0.153744	0	27	20				
COL5A3	50509	broad.mit.edu	37	19	10073543	10073543	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:10073543G>A	uc002mmq.1	-	65	4889	c.4803C>T	c.(4801-4803)TCC>TCT	p.S1601S		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	1601	Fibrillar collagen NC1.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			GCTTTTCCTTGGACCAGGAGG	0.532		NaN											0	0	0	0.09319	0	9	14				
SMARCA4	6597	broad.mit.edu	37	19	11136115	11136115	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:11136115G>C	uc002mqf.3	+	22	3383	c.3099G>C	c.(3097-3099)AAG>AAC	p.K1033N	SMARCA4_uc010dxp.2_Missense_Mutation_p.K1033N|SMARCA4_uc010dxo.2_Missense_Mutation_p.K1033N|SMARCA4_uc002mqg.1_Missense_Mutation_p.K1033N|SMARCA4_uc010dxq.2_Missense_Mutation_p.K1033N|SMARCA4_uc010dxr.2_Missense_Mutation_p.K1033N|SMARCA4_uc002mqj.3_Missense_Mutation_p.K1033N|SMARCA4_uc010dxs.2_Missense_Mutation_p.K1033N|SMARCA4_uc010dxt.1_Missense_Mutation_p.K253N|SMARCA4_uc002mqh.3_Missense_Mutation_p.K156N|SMARCA4_uc002mqi.1_Missense_Mutation_p.K236N	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1033					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				GCGGCACCAAGACCCTGATGA	0.632		NaN	F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				0	0	0	0.214465	0	29	118		Valid		
RFX1	5989	broad.mit.edu	37	19	14076445	14076445	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:14076445G>A	uc002mxv.2	-	15	2378	c.2106C>T	c.(2104-2106)CCC>CCT	p.P702P		NM_002918	NP_002909	P22670	RFX1_HUMAN	regulatory factor X1	702					immune response	nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			lung(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(19;6.67e-23)			CACTGGGGATGGGCCGCAGCA	0.652		NaN											0	0	0	0.105934	0	12	43				
JAK3	3718	broad.mit.edu	37	19	17948866	17948866	+	Missense_Mutation	SNP	T	T	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:17948866T>C	uc002nhn.3	-	12	1676	c.1576A>G	c.(1576-1578)AAC>GAC	p.N526D	JAK3_uc010ebh.2_RNA|JAK3_uc002nho.2_Missense_Mutation_p.N526D	NM_000215	NP_000206	P52333	JAK3_HUMAN	Janus kinase 3	526	Protein kinase 1.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			haematopoietic_and_lymphoid_tissue(40)|lung(5)|breast(5)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	56						TGGCCCAGGTTCTCATGCTGA	0.557		2	Mis		acute megakaryocytic leukemia|								0	0	0	0.055883	0	18	44				
HAPLN4	404037	broad.mit.edu	37	19	19369602	19369602	+	Missense_Mutation	SNP	G	G	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:19369602G>T	uc002nmb.2	-	4	602	c.547C>A	c.(547-549)CGC>AGC	p.R183S	HAPLN4_uc002nmc.2_Missense_Mutation_p.R183S	NM_023002	NP_075378	Q86UW8	HPLN4_HUMAN	hyaluronan and proteoglycan link protein 4	183	Link 1.				cell adhesion	proteinaceous extracellular matrix	hyaluronic acid binding			pancreas(1)	1			Epithelial(12;0.00575)			GCGCACGCGCGCTGCGCCTCC	0.706		NaN											1	0	1.02788e-11	0.160694	1.0806e-11	11	18				
DPY19L3	147991	broad.mit.edu	37	19	32930745	32930745	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:32930745C>G	uc002ntg.2	+	8	960	c.784C>G	c.(784-786)CAA>GAA	p.Q262E	DPY19L3_uc002nth.1_Missense_Mutation_p.Q262E|DPY19L3_uc002nti.1_RNA	NM_207325	NP_997208	Q6ZPD9	D19L3_HUMAN	dpy-19-like 3	262	Helical; (Potential).					integral to membrane				ovary(4)	4	Esophageal squamous(110;0.162)					GCAATTTAATCAATTTATGAT	0.393		NaN											0	0	0	0.139131	0	44	48				
APLP1	333	broad.mit.edu	37	19	36370075	36370075	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:36370075C>A	uc002oce.2	+	16	1948	c.1810C>A	c.(1810-1812)CGC>AGC	p.R604S	APLP1_uc010xsz.1_Missense_Mutation_p.R565S|APLP1_uc002ocf.2_Missense_Mutation_p.R605S|APLP1_uc002ocg.2_Missense_Mutation_p.R508S|APLP1_uc010xta.1_Missense_Mutation_p.R598S	NM_005166	NP_005157	P51693	APLP1_HUMAN	amyloid precursor-like protein 1 isoform 2	604	Cytoplasmic (Potential).|Basolateral sorting signal (By similarity).				apoptosis|cell adhesion|cellular response to norepinephrine stimulus|endocytosis|negative regulation of cAMP biosynthetic process|nervous system development|organ morphogenesis	basement membrane|integral to membrane|perinuclear region of cytoplasm|plasma membrane	alpha-2A adrenergic receptor binding|alpha-2B adrenergic receptor binding|alpha-2C adrenergic receptor binding|heparin binding|identical protein binding|metal ion binding			ovary(2)	2	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GCTGCTCCTGCGCAGGAAGAA	0.657		NaN											1	0	1.85244e-09	0.083992	1.91672e-09	23	107				
MEGF8	1954	broad.mit.edu	37	19	42880156	42880156	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:42880156C>T	uc002otl.3	+	41	8201	c.7566C>T	c.(7564-7566)GTC>GTT	p.V2522V	MEGF8_uc002otm.3_Silent_p.V2130V|MEGF8_uc002otn.3_Silent_p.V183V	NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	2589	Extracellular (Potential).					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				TGCTGGTGGTCCGCGGCGTGC	0.692		NaN											0	0	0	0.139131	0	87	149				
RSPH6A	81492	broad.mit.edu	37	19	46308019	46308019	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:46308019C>G	uc002pdm.2	-	3	1287	c.1144G>C	c.(1144-1146)GAG>CAG	p.E382Q	RSPH6A_uc002pdl.2_Missense_Mutation_p.E118Q	NM_030785	NP_110412	Q9H0K4	RSH6A_HUMAN	radial spokehead-like 1	382	Glu-rich.					intracellular				ovary(1)|central_nervous_system(1)	2						tccATGACCTCGCCACCTTCC	0.358		NaN											0	0	0	0.105934	0	12	20				
LIG1	3978	broad.mit.edu	37	19	48634393	48634393	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:48634393G>A	uc002pia.1	-	19	1881	c.1761C>T	c.(1759-1761)TTC>TTT	p.F587F	LIG1_uc010xze.1_Silent_p.F280F|LIG1_uc002phz.1_RNA|LIG1_uc002pib.1_RNA|LIG1_uc010xzf.1_Silent_p.F519F|LIG1_uc010xzg.1_Silent_p.F556F	NM_000234	NP_000225	P18858	DNLI1_HUMAN	DNA ligase I	587					anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			large_intestine(2)|lung(1)	3		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)	GATTCCTGCTGAAGATCTTCA	0.577		NaN						NER					0	0	0	0.047766	0	7	117				
DBP	1628	broad.mit.edu	37	19	49134232	49134232	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:49134232C>G	uc002pjx.3	-	4	1228	c.840G>C	c.(838-840)GAG>GAC	p.E280D	DBP_uc002pjy.2_3'UTR	NM_001352	NP_001343	Q10586	DBP_HUMAN	D site of albumin promoter (albumin D-box)	280					regulation of transcription from RNA polymerase II promoter|rhythmic process	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000112)|GBM - Glioblastoma multiforme(486;0.00615)|Epithelial(262;0.0155)		ATATCTGGTTCTCCTTGAGCC	0.652		NaN											0	0	0	0.163468	0	24	33				
RASIP1	54922	broad.mit.edu	37	19	49224075	49224075	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:49224075G>C	uc002pki.2	-	12	3069	c.2872C>G	c.(2872-2874)CCC>GCC	p.P958A	MAMSTR_uc002pkg.2_5'Flank|RASIP1_uc002pkh.2_Missense_Mutation_p.P219A	NM_017805	NP_060275	Q5U651	RAIN_HUMAN	Ras-interacting protein 1	958					signal transduction	Golgi stack|perinuclear region of cytoplasm				pancreas(1)	1		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000272)|Epithelial(262;0.0155)|GBM - Glioblastoma multiforme(486;0.0222)		GTGGCCACGGGAGGCCCATGG	0.602		NaN											0	0	0	0.139131	0	87	150				
AP2A1	160	broad.mit.edu	37	19	50302947	50302947	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:50302947G>A	uc002ppn.2	+	10	1407	c.1196G>A	c.(1195-1197)CGG>CAG	p.R399Q	AP2A1_uc010enj.1_RNA|AP2A1_uc002ppo.2_Missense_Mutation_p.R399Q|AP2A1_uc002ppp.1_5'Flank	NM_014203	NP_055018	O95782	AP2A1_HUMAN	adaptor-related protein complex 2, alpha 1	399					axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|Golgi to endosome transport|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|clathrin coat of trans-Golgi network vesicle|cytosol	protein binding|protein transporter activity			ovary(2)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0023)|GBM - Glioblastoma multiforme(134;0.0157)		ATGTGTGACCGGAGCAATGCC	0.592		NaN											0	0	0	0.139131	0	83	136				
ZNF761	388561	broad.mit.edu	37	19	53959831	53959831	+	Silent	SNP	T	T	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:53959831T>C	uc010eqp.2	+	7	2528	c.2070T>C	c.(2068-2070)TAT>TAC	p.Y690Y	ZNF761_uc010ydy.1_Silent_p.Y636Y|ZNF761_uc002qbt.1_Silent_p.Y636Y	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	690	C2H2-type 18.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		AGAAACCTTATAAGTGTAATG	0.393		NaN											0	0	0	0.184627	0	5	75				
TTYH1	57348	broad.mit.edu	37	19	54932494	54932494	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:54932494G>A	uc002qfq.2	+	3	441	c.349G>A	c.(349-351)GAT>AAT	p.D117N	TTYH1_uc010yey.1_Missense_Mutation_p.D166N|TTYH1_uc002qfr.2_Missense_Mutation_p.D117N|TTYH1_uc002qft.2_Missense_Mutation_p.D117N|TTYH1_uc002qfu.1_Missense_Mutation_p.D32N	NM_020659	NP_065710	Q9H313	TTYH1_HUMAN	tweety 1 isoform 1	117	Extracellular (Potential).				cell adhesion	chloride channel complex|plasma membrane	chloride channel activity|iron ion transmembrane transporter activity				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0767)		TGAGACCAGTGATGGGGTGTC	0.637		NaN											0	0	0	0.124865	0	36	164				
ZNF550	162972	broad.mit.edu	37	19	58058953	58058953	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:58058953C>T	uc002qpe.1	-	2	536	c.536G>A	c.(535-537)CGA>CAA	p.R179Q	ZNF547_uc002qpm.3_Intron|ZNF549_uc010eud.1_Intron|ZNF550_uc002qpc.2_RNA|ZNF550_uc010eue.1_RNA|ZNF550_uc002qpd.2_RNA	NM_001039654	NP_001034743	Q7Z398	ZN550_HUMAN	zinc finger protein 550	220	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		CCTCTGATGTCGAACGAGATA	0.483		NaN											0	0	0	0.139131	0	42	65				
ZSCAN22	342945	broad.mit.edu	37	19	58846394	58846394	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:58846394C>G	uc002qsc.2	+	2	373	c.226C>G	c.(226-228)CAG>GAG	p.Q76E	ZSCAN22_uc010yhz.1_Missense_Mutation_p.Q76E	NM_181846	NP_862829	P10073	ZSC22_HUMAN	zinc finger and SCAN domain containing 22	76	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)	1		all_cancers(17;3.11e-12)|all_epithelial(17;9.43e-09)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0289)		GCTGTGCTGTCAGTGGCTGCA	0.657		NaN											0	0	0	0.09319	0	11	128				
LPIN1	23175	broad.mit.edu	37	2	11964910	11964910	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:11964910C>T	uc010yjn.1	+	21	2940	c.2666C>T	c.(2665-2667)TCA>TTA	p.S889L	LPIN1_uc010yjm.1_Missense_Mutation_p.S974L|LPIN1_uc002rbt.2_Missense_Mutation_p.S889L|LPIN1_uc010yjo.1_Missense_Mutation_p.S390L	NM_145693	NP_663731	Q14693	LPIN1_HUMAN	lipin 1	889					fatty acid catabolic process|transcription, DNA-dependent|triglyceride biosynthetic process|triglyceride mobilization	cytosol|endoplasmic reticulum membrane	phosphatidate phosphatase activity			ovary(2)|large_intestine(1)|skin(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.11)|OV - Ovarian serous cystadenocarcinoma(76;0.173)		CATTCTGCCTCAGCGTAAAAT	0.517		NaN											0	0	0	0.146539	0	12	35				
TRIB2	28951	broad.mit.edu	37	2	12880633	12880633	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:12880633G>A	uc002rbv.3	+	3	2181	c.745G>A	c.(745-747)GTG>ATG	p.V249M	TRIB2_uc010yjp.1_Missense_Mutation_p.V113M	NM_021643	NP_067675	Q92519	TRIB2_HUMAN	tribbles homolog 2	249	Protein kinase.				negative regulation of fat cell differentiation|negative regulation of interleukin-10 biosynthetic process|negative regulation of protein kinase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|regulation of MAP kinase activity	cytoplasm|cytoskeleton|nucleus	ATP binding|protein kinase activity|protein kinase inhibitor activity|transcription factor binding|ubiquitin protein ligase binding|ubiquitin-protein ligase regulator activity			stomach(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CACCATGTTGGTGGGGCGGTA	0.582		NaN											0	0	0	0.080422	0	32	22				
APOB	338	broad.mit.edu	37	2	21224807	21224807	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:21224807C>G	uc002red.2	-	29	13615	c.13487G>C	c.(13486-13488)AGA>ACA	p.R4496T		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	4496					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CAGTTTATATCTAAACTGCTG	0.363		NaN											0	0	0	0.080935	0	11	38				
C2orf16	84226	broad.mit.edu	37	2	27800241	27800241	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:27800241G>A	uc002rkz.3	+	1	853	c.802G>A	c.(802-804)GAA>AAA	p.E268K		NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	268										large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					GATTACTCCGGAACTCAAGCA	0.463		NaN											0	0	0	0.193644	0	27	37				
PLEKHH2	130271	broad.mit.edu	37	2	43991401	43991401	+	Missense_Mutation	SNP	T	T	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:43991401T>C	uc010yny.1	+	29	4276	c.4193T>C	c.(4192-4194)ATG>ACG	p.M1398T		NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	1398	FERM.					cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				AAGAGTCTAATGACCTTTGGA	0.328		NaN											0	0	0	0.189662	0	16	19				
RHOQ	23433	broad.mit.edu	37	2	46770291	46770291	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:46770291G>A	uc002rva.2	+	1	425	c.106G>A	c.(106-108)GAG>AAG	p.E36K	ATP6V1E2_uc002ruz.2_5'Flank	NM_012249	NP_036381	P17081	RHOQ_HUMAN	ras-like protein TC10 precursor	36					cortical actin cytoskeleton organization|insulin receptor signaling pathway|negative regulation of establishment of protein localization in plasma membrane|positive regulation of filopodium assembly|positive regulation of glucose import|positive regulation of transcription from RNA polymerase II promoter|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	actin filament|cytosol|plasma membrane	GBD domain binding|GTP binding|GTPase activity|profilin binding			skin(2)	2		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)	LUSC - Lung squamous cell carcinoma(58;0.114)			CGCCTTCCCGGAGGAGTACGT	0.652		NaN											0	0	0	0.139131	0	51	172				
NRXN1	9378	broad.mit.edu	37	2	50733744	50733744	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:50733744C>G	uc010fbq.2	-	13	3983	c.2506G>C	c.(2506-2508)GAG>CAG	p.E836Q	NRXN1_uc002rxb.3_Missense_Mutation_p.E468Q|NRXN1_uc002rxe.3_Missense_Mutation_p.E796Q|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			AAAAGAGTCTCGGGACCTTTG	0.378		NaN											0	0	0	0.069234	0	9	19				
KIAA1841	84542	broad.mit.edu	37	2	61333734	61333734	+	Missense_Mutation	SNP	A	A	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:61333734A>G	uc002saw.3	+	14	1851	c.1548A>G	c.(1546-1548)ATA>ATG	p.I516M	KIAA1841_uc002sax.3_Missense_Mutation_p.I370M|KIAA1841_uc002say.2_Missense_Mutation_p.I516M	NM_001129993	NP_001123465	Q6NSI8	K1841_HUMAN	KIAA1841 protein isoform a	516											0			Epithelial(17;0.193)			AAAAGGGTATAGAATGTGATG	0.348		NaN											0	0	0	0.0918	0	18	45				
ATP6V1B1	525	broad.mit.edu	37	2	71187068	71187068	+	Splice_Site	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:71187068G>A	uc002shj.2	+	6	533	c.446_splice	c.e6-1	p.G149_splice	ATP6V1B1_uc002shi.1_Splice_Site_p.G149_splice|ATP6V1B1_uc010fdv.2_Splice_Site_p.G149_splice|ATP6V1B1_uc010fdw.2_Splice_Site|ATP6V1B1_uc010fdx.2_Splice_Site_p.G107_splice	NM_001692	NP_001683	P15313	VATB1_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1						ATP hydrolysis coupled proton transport|calcium ion homeostasis|cellular iron ion homeostasis|excretion|inner ear morphogenesis|insulin receptor signaling pathway|ossification|pH reduction|sensory perception of sound|transferrin transport	apical plasma membrane|basolateral plasma membrane|cytosol|endomembrane system|lateral plasma membrane|microvillus|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			skin(1)	1						CCCTCTCCCAGGCCAGCCCAT	0.547		NaN											0	0	0	0.092188	0	30	103				
CNTNAP5	129684	broad.mit.edu	37	2	125261952	125261952	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:125261952C>T	uc002tno.2	+	8	1507	c.1143C>T	c.(1141-1143)CCC>CCT	p.P381P	CNTNAP5_uc010flu.2_Silent_p.P382P	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	381	Laminin G-like 2.|Extracellular (Potential).				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		TGCTGCTGCCCGGCACCCCCC	0.512		NaN											0	0	0	0.139131	0	42	25				
THSD7B	80731	broad.mit.edu	37	2	137928489	137928489	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:137928489C>T	uc002tva.1	+	6	1611	c.1611C>T	c.(1609-1611)GCC>GCT	p.A537A	THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Silent_p.A427A	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		TTCTGAAGGCCGTCTGCCAGA	0.483		NaN											0	0	0	0.160694	0	11	12				
LYPD6B	130576	broad.mit.edu	37	2	150071149	150071149	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:150071149G>A	uc002twv.1	+	7	950	c.549G>A	c.(547-549)CAG>CAA	p.Q183Q	LYPD6B_uc002tww.1_Silent_p.Q145Q|LYPD6B_uc002twx.1_Silent_p.Q145Q	NM_177964	NP_808879	Q8NI32	LPD6B_HUMAN	LY6/PLAUR domain containing 6B	159						anchored to membrane|plasma membrane					0						TGCACGCTCAGAGAACATCTG	0.493		NaN											0	0	0	0.139131	0	63	148				
TTN	7273	broad.mit.edu	37	2	179610636	179610636	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:179610636C>G	uc002unb.2	-	46	16715	c.16491G>C	c.(16489-16491)AAG>AAC	p.K5497N	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTAGTTGCTCTTTAAGACCA	0.408		NaN											0	0	0	0.189662	0	15	44				
FAM171B	165215	broad.mit.edu	37	2	187627410	187627410	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:187627410G>A	uc002ups.2	+	8	2453	c.2341G>A	c.(2341-2343)GGA>AGA	p.G781R	FAM171B_uc002upr.1_Missense_Mutation_p.G748R|FAM171B_uc002upt.2_Missense_Mutation_p.G250R	NM_177454	NP_803237	Q6P995	F171B_HUMAN	KIAA1946	781	Cytoplasmic (Potential).					integral to membrane	DNA binding			ovary(6)|breast(3)|central_nervous_system(1)	10						AGAGTCGCCAGGAAGGAAAAG	0.502		NaN											0	0	0	0.150653	0	3	18				
ALS2CR11	151254	broad.mit.edu	37	2	202400897	202400897	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:202400897C>T	uc002uye.2	-	13	1401	c.1353G>A	c.(1351-1353)CAG>CAA	p.Q451Q	ALS2CR11_uc002uyf.2_Silent_p.Q451Q|ALS2CR11_uc010fti.2_Intron	NM_152525	NP_689738	Q53TS8	AL2SA_HUMAN	amyotrophic lateral sclerosis 2 (juvenile)	451										large_intestine(1)|ovary(1)|skin(1)	3						TTATTGTTTCCTGGTTAGAAA	0.373		NaN											0	0	0	0.047766	0	8	55				
INO80D	54891	broad.mit.edu	37	2	206882469	206882469	+	Missense_Mutation	SNP	A	A	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:206882469A>C	uc002vaz.3	-	8	1882	c.1477T>G	c.(1477-1479)TGC>GGC	p.C493G		NM_017759	NP_060229	Q53TQ3	IN80D_HUMAN	INO80 complex subunit D	493					DNA recombination|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)	1						GGCACAGAGCACTGCTGTCCA	0.373		NaN											0	0	0	0.069234	0	9	11				
TNS1	7145	broad.mit.edu	37	2	218700908	218700908	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:218700908C>T	uc002vgt.2	-	18	3057	c.2659G>A	c.(2659-2661)GCA>ACA	p.A887T	TNS1_uc002vgr.2_Missense_Mutation_p.A887T|TNS1_uc002vgs.2_Missense_Mutation_p.A887T|TNS1_uc010zjv.1_Missense_Mutation_p.A887T	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	887						cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		GGGGGCTCTGCAGGCTGCTTC	0.582		NaN											0	0	0	0.047766	0	6	51				
SH3BP4	23677	broad.mit.edu	37	2	235943684	235943684	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr2:235943684G>A	uc002vvp.2	+	3	431	c.38G>A	c.(37-39)GGC>GAC	p.G13D	SH3BP4_uc010fym.2_Missense_Mutation_p.G13D|SH3BP4_uc002vvq.2_Missense_Mutation_p.G13D	NM_014521	NP_055336	Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	13					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			skin(3)|ovary(1)	4		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		AACTCCAATGGCCTCCCTCGC	0.552		NaN											0	0	0	0.021553	0	5	30				
SFRS6	6431	broad.mit.edu	37	20	42088479	42088479	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr20:42088479G>C	uc010zwg.1	+	3	495	c.325G>C	c.(325-327)GAA>CAA	p.E109Q	SFRS6_uc002xki.2_5'UTR|SFRS6_uc002xkk.2_Missense_Mutation_p.E109Q	NM_006275	NP_006266	Q13247	SRSF6_HUMAN	arginine/serine-rich splicing factor 6	109					mRNA 3'-end processing|mRNA export from nucleus|mRNA splice site selection|termination of RNA polymerase II transcription	nucleoplasm	nucleotide binding|protein binding|RNA binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			TGTTCGTACAGAATACAGGCT	0.398		NaN											0	0	0	0.139131	0	45	66				
C20orf111	51526	broad.mit.edu	37	20	42825950	42825950	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr20:42825950C>T	uc002xlk.2	-	4	758	c.621G>A	c.(619-621)AAG>AAA	p.K207K		NM_016470	NP_057554	Q9NX31	CT111_HUMAN	oxidative stress responsive 1	207											0		Myeloproliferative disorder(115;0.028)	COAD - Colon adenocarcinoma(18;0.00189)			CATGCCATCTCTTACACTGGC	0.488		NaN											0	0	0	0.153744	0	23	60				
NFATC2	4773	broad.mit.edu	37	20	50139887	50139887	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr20:50139887G>C	uc002xwd.2	-	2	1113	c.893C>G	c.(892-894)GCT>GGT	p.A298G	NFATC2_uc002xwc.2_Missense_Mutation_p.A298G|NFATC2_uc010zyv.1_Missense_Mutation_p.A79G|NFATC2_uc010zyw.1_Missense_Mutation_p.A79G|NFATC2_uc010zyx.1_Missense_Mutation_p.A278G|NFATC2_uc010zyy.1_Missense_Mutation_p.A79G|NFATC2_uc010zyz.1_Missense_Mutation_p.A79G|NFATC2_uc002xwe.2_Missense_Mutation_p.A278G	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,	298					B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					GGCAGAGCCAGCCACAGGGGG	0.706		NaN											0	0	0	0.132662	0	13	20				
MYT1	4661	broad.mit.edu	37	20	62871220	62871220	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr20:62871220C>T	uc002yii.2	+	22	3565	c.3201C>T	c.(3199-3201)CTC>CTT	p.L1067L	MYT1_uc002yij.2_Silent_p.L726L|MYT1_uc002yik.2_Silent_p.L33L	NM_004535	NP_004526	Q01538	MYT1_HUMAN	myelin transcription factor 1	1067					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					GCCAGGCCCTCATCCAAAGTC	0.592		NaN											0	0	0	0.139131	0	40	260				
USP25	29761	broad.mit.edu	37	21	17250767	17250767	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr21:17250767C>T	uc002yjy.1	+	24	3358	c.3141C>T	c.(3139-3141)CTC>CTT	p.L1047L	USP25_uc011aby.1_Silent_p.L1117L|USP25_uc002yjz.1_Silent_p.L1079L|USP25_uc010gla.1_Silent_p.L442L	NM_013396	NP_037528	Q9UHP3	UBP25_HUMAN	ubiquitin specific peptidase 25	1047					protein modification process|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(3)|liver(2)	5				Epithelial(23;7.55e-05)|all cancers(11;0.000429)|COAD - Colon adenocarcinoma(22;0.00543)|OV - Ovarian serous cystadenocarcinoma(11;0.00743)|Colorectal(24;0.0116)|Lung(58;0.0853)|LUSC - Lung squamous cell carcinoma(23;0.0889)		TGTTGTCCCTCAGTCGAACTC	0.433		NaN											0	0	0	0.139131	0	32	35				
TMPRSS3	64699	broad.mit.edu	37	21	43802184	43802184	+	Silent	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr21:43802184G>C	uc002zbb.2	-	9	1143	c.942C>G	c.(940-942)CTC>CTG	p.L314L	TMPRSS3_uc002zay.2_Silent_p.L72L|TMPRSS3_uc002zaz.2_Silent_p.L187L|TMPRSS3_uc002zba.2_Silent_p.L187L|TMPRSS3_uc002zbc.2_Silent_p.L314L|TMPRSS3_uc002zbd.2_Silent_p.L314L	NM_024022	NP_076927	P57727	TMPS3_HUMAN	transmembrane protease, serine 3 isoform 1	314	Peptidase S1.|Extracellular (Potential).				cellular sodium ion homeostasis|proteolysis	endoplasmic reticulum membrane|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity|sodium channel regulator activity			ovary(2)|breast(1)	3						CATTGAACGTGAGTGGCCCGG	0.373		NaN											0	0	0	0.139131	0	36	44				
PWP2	5822	broad.mit.edu	37	21	45550606	45550606	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr21:45550606C>G	uc002zeb.2	+	21	2803	c.2713C>G	c.(2713-2715)CTG>GTG	p.L905V	C21orf33_uc002zec.3_5'Flank|C21orf33_uc002zed.3_5'Flank	NM_005049	NP_005040	Q15269	PWP2_HUMAN	PWP2 periodic tryptophan protein homolog	905						cytoplasm|nucleolus	signal transducer activity			pancreas(1)	1				STAD - Stomach adenocarcinoma(101;0.172)|Colorectal(79;0.2)		CAGCCTGCATCTGCTTGGAGG	0.582		NaN											0	0	0	0.139131	0	53	60				
C21orf70	85395	broad.mit.edu	37	21	46363637	46363637	+	Silent	SNP	C	C	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr21:46363637C>A	uc002zgl.2	+	2	186	c.168C>A	c.(166-168)ACC>ACA	p.T56T	C21orf70_uc002zgm.2_Silent_p.T56T	NM_058190	NP_478070	Q9NSI2	CU070_HUMAN	hypothetical protein LOC85395	56											0				Colorectal(79;0.248)		TTGCCAGGACCAAGATAGACC	0.552		NaN											1	0	1.04352e-10	0.193644	1.09004e-10	29	69				
PCNT	5116	broad.mit.edu	37	21	47786794	47786794	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr21:47786794G>C	uc002zji.3	+	15	3012	c.2905G>C	c.(2905-2907)GAT>CAT	p.D969H	PCNT_uc002zjj.2_Missense_Mutation_p.D851H	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	969					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					GTCCAGCCTTGATTCTTTGGA	0.562		NaN											0	0	0	0.134883	0	26	82				
CHEK2	11200	broad.mit.edu	37	22	29106036	29106036	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr22:29106036G>A	uc003adu.1	-	7	876	c.804C>T	c.(802-804)CTC>CTT	p.L268L	CHEK2_uc003ads.1_Silent_p.L47L|CHEK2_uc010gvh.1_Silent_p.L177L|CHEK2_uc010gvi.1_Silent_p.L268L|CHEK2_uc010gvj.1_Intron|CHEK2_uc003adr.1_RNA|CHEK2_uc010gvk.1_RNA|CHEK2_uc003adt.1_Silent_p.L311L|CHEK2_uc003adv.1_Silent_p.L268L|CHEK2_uc003adw.1_Silent_p.L268L|CHEK2_uc003adx.1_Silent_p.L47L|CHEK2_uc003ady.1_Silent_p.L268L|CHEK2_uc003adz.1_Silent_p.L72L	NM_007194	NP_009125	O96017	CHK2_HUMAN	protein kinase CHK2 isoform a	268	Protein kinase.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|stomach(1)|ovary(1)|lung(1)	20						TTTCAACATTGAGAGCTGGGT	0.264		NaN	F			breast 		Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|CHEK2-associated_cancer				0	0	0	0.058154	0	7	5				
EIF3L	51386	broad.mit.edu	37	22	38266268	38266268	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr22:38266268G>A	uc003auf.2	+	8	752	c.665G>A	c.(664-666)TGG>TAG	p.W222*	EIF3L_uc003aue.1_Nonsense_Mutation_p.W222*|EIF3L_uc011ann.1_Nonsense_Mutation_p.W174*|EIF3L_uc003aug.2_Nonsense_Mutation_p.W114*|EIF3L_uc003auh.2_5'UTR	NM_016091	NP_057175	Q9Y262	EIF3L_HUMAN	eukaryotic translation initiation factor 3	222						eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			ovary(1)	1						CCCAAAATCTGGAATGTTCAT	0.458		NaN											0	0	0	0.175082	0	16	25				
EP300	2033	broad.mit.edu	37	22	41572404	41572404	+	Nonsense_Mutation	SNP	C	C	T	rs139310551		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr22:41572404C>T	uc003azl.3	+	30	5328	c.4933C>T	c.(4933-4935)CGA>TGA	p.R1645*		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1645	Binding region for E1A adenovirus.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding	p.R1645R(1)		haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						CTCTTCACTCCGAAGAGCCCA	0.557		NaN	T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.080422	0	34	13		Valid		
EP300	2033	broad.mit.edu	37	22	41572932	41572932	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr22:41572932C>G	uc003azl.3	+	31	5612	c.5217C>G	c.(5215-5217)ATC>ATG	p.I1739M		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1739	Binding region for E1A adenovirus.|TAZ-type 2.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						AGCGCTGCATCCAGTCTCTGG	0.562		NaN	T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.124865	0	37	16		Valid		
EP300	2033	broad.mit.edu	37	22	41573079	41573079	+	Silent	SNP	C	C	G	rs143551315	byFrequency	TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr22:41573079C>G	uc003azl.3	+	31	5759	c.5364C>G	c.(5362-5364)CTC>CTG	p.L1788L		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1788	Binding region for E1A adenovirus.|TAZ-type 2.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						TCATTGCCCTCTGCTGCTACC	0.572		NaN	T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.139131	0	54	23				
EP300	2033	broad.mit.edu	37	22	41573719	41573719	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr22:41573719C>G	uc003azl.3	+	31	6399	c.6004C>G	c.(6004-6006)CAG>GAG	p.Q2002E		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	2002					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						AGGATTGCCTCAGCCCCAGCA	0.602		NaN	T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.131918	0	37	17		Valid		
EP300	2033	broad.mit.edu	37	22	41573838	41573838	+	Silent	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr22:41573838C>G	uc003azl.3	+	31	6518	c.6123C>G	c.(6121-6123)CTC>CTG	p.L2041L		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	2041	Interaction with HTLV-1 Tax.|Interaction with NCOA2.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						TCAGCCCACTCAAACCAGGCA	0.547		NaN	T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.139131	0	48	25				
EP300	2033	broad.mit.edu	37	22	41573889	41573889	+	Silent	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr22:41573889C>G	uc003azl.3	+	31	6569	c.6174C>G	c.(6172-6174)CTC>CTG	p.L2058L		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	2058	Interaction with HTLV-1 Tax.|Interaction with NCOA2.				apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						TGCGGACTCTCAGGTCTCCCA	0.552		NaN	T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.139131	0	52	24				
MEI1	150365	broad.mit.edu	37	22	42112115	42112115	+	Missense_Mutation	SNP	T	T	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr22:42112115T>C	uc003baz.1	+	5	519	c.494T>C	c.(493-495)ATC>ACC	p.I165T	MEI1_uc003bay.3_Missense_Mutation_p.I165T|MEI1_uc011apd.1_RNA	NM_152513	NP_689726	Q5TIA1	MEI1_HUMAN	meiosis defective 1	165							binding			central_nervous_system(1)|skin(1)	2						GTGGATGCCATCCCTGCTCTG	0.517		NaN											0	0	0	0.160694	0	14	32				
ITPR1	3708	broad.mit.edu	37	3	4711438	4711438	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:4711438G>A	uc003bqa.2	+	19	2335	c.1987G>A	c.(1987-1989)GAC>AAC	p.D663N	ITPR1_uc010hca.1_Missense_Mutation_p.D648N|ITPR1_uc011asu.1_Intron|ITPR1_uc010hcb.1_Missense_Mutation_p.D648N	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	663	Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		CACCAACGCTGACATCCTGAT	0.468		NaN											0	0	0	0.02938	0	6	13				
ITPR1	3708	broad.mit.edu	37	3	4711446	4711446	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:4711446G>A	uc003bqa.2	+	19	2343	c.1995G>A	c.(1993-1995)CTG>CTA	p.L665L	ITPR1_uc010hca.1_Silent_p.L650L|ITPR1_uc011asu.1_Intron|ITPR1_uc010hcb.1_Silent_p.L650L	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	665	Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		CTGACATCCTGATTGAGACCA	0.463		NaN											0	0	0	0.184627	0	5	12				
ALAS1	211	broad.mit.edu	37	3	52245397	52245397	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:52245397C>G	uc003dcy.1	+	10	1766	c.1429C>G	c.(1429-1431)CTG>GTG	p.L477V	ALAS1_uc003dcz.1_Missense_Mutation_p.L477V|ALAS1_uc011bec.1_Missense_Mutation_p.L494V	NM_000688	NP_000679	P13196	HEM1_HUMAN	5-aminolevulinate synthase 1 precursor	477					heme biosynthetic process	mitochondrial matrix	5-aminolevulinate synthase activity|pyridoxal phosphate binding|transferase activity, transferring nitrogenous groups			ovary(2)|upper_aerodigestive_tract(1)	3				BRCA - Breast invasive adenocarcinoma(193;5.13e-05)|Kidney(197;0.000583)|KIRC - Kidney renal clear cell carcinoma(197;0.000751)	Glycine(DB00145)|Pyridoxal Phosphate(DB00114)	CACCACCTCTCTGCCACCCAT	0.592		NaN											0	0	0	0.055883	0	20	9				
FAM19A4	151647	broad.mit.edu	37	3	68802156	68802156	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:68802156G>C	uc003dnh.1	-	4	587	c.144C>G	c.(142-144)ATC>ATG	p.I48M	FAM19A4_uc003dni.1_Missense_Mutation_p.I48M	NM_182522	NP_872328	Q96LR4	F19A4_HUMAN	family with sequence similarity 19 (chemokine	48						extracellular region				skin(2)	2		Lung NSC(201;0.0198)		BRCA - Breast invasive adenocarcinoma(55;1.38e-05)|Epithelial(33;0.000124)|LUSC - Lung squamous cell carcinoma(21;0.0248)|KIRC - Kidney renal clear cell carcinoma(39;0.0729)|Kidney(39;0.0904)		TCCCTTGCTTGATTTGGTGGT	0.493		NaN											0	0	0	0.144211	0	23	10				
CADM2	253559	broad.mit.edu	37	3	86010686	86010686	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:86010686G>C	uc003dqj.2	+	7	1458	c.832G>C	c.(832-834)GGT>CGT	p.G278R	CADM2_uc003dqk.2_Missense_Mutation_p.G287R|CADM2_uc003dql.2_Missense_Mutation_p.G280R	NM_153184	NP_694854	Q8N3J6	CADM2_HUMAN	immunoglobulin superfamily, member 4D	278	Ig-like C2-type 2.|Extracellular (Potential).				adherens junction organization|cell junction assembly	integral to membrane|plasma membrane				ovary(1)|lung(1)|kidney(1)|skin(1)	4		Lung NSC(201;0.0148)		LUSC - Lung squamous cell carcinoma(29;0.000815)|Lung(72;0.00304)|BRCA - Breast invasive adenocarcinoma(55;0.156)|Epithelial(33;0.157)		GGTTGTGAGTGGTAGGGAGCT	0.433		NaN											0	0	0	0.163468	0	26	83				
NSUN3	63899	broad.mit.edu	37	3	93802971	93802971	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:93802971C>G	uc003drl.1	+	3	259	c.143C>G	c.(142-144)TCA>TGA	p.S48*		NM_022072	NP_071355	Q9H649	NSUN3_HUMAN	NOL1/NOP2/Sun domain family, member 3	48							methyltransferase activity			skin(1)	1						ACATCTCCATCATGCTGGCAA	0.338		NaN											0	0	0	0.099896	0	23	24				
BBX	56987	broad.mit.edu	37	3	107520009	107520009	+	Silent	SNP	A	A	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:107520009A>G	uc010hpr.2	+	17	2946	c.2619A>G	c.(2617-2619)AAA>AAG	p.K873K	BBX_uc003dwk.3_Silent_p.K843K|BBX_uc003dwl.3_Missense_Mutation_p.N537S|BBX_uc003dwm.3_Silent_p.K843K|BBX_uc003dwo.3_Missense_Mutation_p.N190S	NM_001142568	NP_001136040	Q8WY36	BBX_HUMAN	HMG-BOX transcription factor BBX isoform 1	873					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(3;0.112)			GCAATGACAAATGCTCACACA	0.512		NaN											0	0	0	0.139131	0	43	32				
RPN1	6184	broad.mit.edu	37	3	128356705	128356705	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:128356705G>A	uc003ekr.1	-	3	646	c.570C>T	c.(568-570)AAC>AAT	p.N190N	RPN1_uc011bkq.1_Silent_p.N18N	NM_002950	NP_002941	P04843	RPN1_HUMAN	ribophorin I precursor	190	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|melanosome|oligosaccharyltransferase complex|rough microsome	dolichyl-diphosphooligosaccharide-protein glycotransferase activity|protein binding			ovary(2)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(114;0.189)		AGCGCGTGGGGTTCCCCAGCT	0.532		NaN	T	EVI1	AML								0	0	0	0.108266	0	23	83				
RNF7	9616	broad.mit.edu	37	3	141462354	141462354	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:141462354C>T	uc003eud.2	+	2	312	c.179C>T	c.(178-180)GCC>GTC	p.A60V	RNF7_uc003euc.2_Missense_Mutation_p.P58S|RNF7_uc003eue.2_RNA	NM_014245	NP_055060	Q9UBF6	RBX2_HUMAN	ring finger protein 7 isoform 1	60					anti-apoptosis|induction of apoptosis by oxidative stress|protein neddylation|response to redox state	cytoplasm|nucleus	copper ion binding|NEDD8 ligase activity|protein binding|zinc ion binding				0						CTTTTAGATGCCTGTCTTAGA	0.373		NaN											0	0	0	0.204396	0	16	35				
MAP3K13	9175	broad.mit.edu	37	3	185155308	185155308	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:185155308C>T	uc010hyf.2	+	4	815	c.549C>T	c.(547-549)TTC>TTT	p.F183F	MAP3K13_uc011brt.1_Intron|MAP3K13_uc003fph.3_5'UTR|MAP3K13_uc011bru.1_Silent_p.F39F|MAP3K13_uc003fpi.2_Silent_p.F183F|MAP3K13_uc010hyg.2_Intron	NM_004721	NP_004712	O43283	M3K13_HUMAN	mitogen-activated protein kinase kinase kinase	183	Protein kinase.				activation of MAPKK activity|JNK cascade|positive regulation of NF-kappaB transcription factor activity|protein autophosphorylation	cytoplasm|membrane|membrane fraction	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein homodimerization activity|protein kinase binding			ovary(2)|skin(1)	3	all_cancers(143;7.21e-11)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)			GAGCGGTCTTCTTGGGCAAGT	0.498		NaN											0	0	0	0.139131	0	49	89				
DGKG	1608	broad.mit.edu	37	3	186006603	186006603	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:186006603G>A	uc003fqa.2	-	6	977	c.440C>T	c.(439-441)CCC>CTC	p.P147L	DGKG_uc003fqb.2_Missense_Mutation_p.P147L|DGKG_uc003fqc.2_Missense_Mutation_p.P147L|DGKG_uc011brx.1_Missense_Mutation_p.P147L	NM_001346	NP_001337	P49619	DGKG_HUMAN	diacylglycerol kinase gamma isoform 1	147					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	cytoplasm|plasma membrane	ATP binding|calcium ion binding|diacylglycerol kinase activity			breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	all_cancers(143;3.26e-12)|Ovarian(172;0.0315)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.93e-20)	GBM - Glioblastoma multiforme(93;0.0657)	Phosphatidylserine(DB00144)	CCGAGGGACGGGGGGTTCCAG	0.547		NaN											0	0	0	0.139131	0	100	310				
OPA1	4976	broad.mit.edu	37	3	193384092	193384092	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:193384092G>C	uc003ftm.2	+	26	2855	c.2621G>C	c.(2620-2622)TGC>TCC	p.C874S	OPA1_uc003ftg.2_Missense_Mutation_p.C929S|OPA1_uc003fth.2_Missense_Mutation_p.C893S|OPA1_uc003fti.2_Missense_Mutation_p.C911S|OPA1_uc003ftj.2_Missense_Mutation_p.C892S|OPA1_uc003ftk.2_Missense_Mutation_p.C875S|OPA1_uc003ftl.2_Missense_Mutation_p.C856S|OPA1_uc003ftn.2_Missense_Mutation_p.C838S	NM_015560	NP_056375	O60313	OPA1_HUMAN	optic atrophy 1 isoform 1	874	Mitochondrial intermembrane (By similarity).				apoptosis|axon transport of mitochondrion|inner mitochondrial membrane organization|mitochondrial fission|mitochondrial fusion|positive regulation of anti-apoptosis|response to stimulus|visual perception	dendrite|integral to membrane|mitochondrial crista|mitochondrial intermembrane space|mitochondrial outer membrane	GTP binding|GTPase activity|magnesium ion binding|protein binding				0	all_cancers(143;9.56e-09)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;9.19e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000162)		CAGTTGGAATGCAATGATGTG	0.358		NaN											0	0	0	0.0918	0	21	56				
SENP5	205564	broad.mit.edu	37	3	196613169	196613169	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:196613169C>T	uc003fwz.3	+	2	1366	c.1117C>T	c.(1117-1119)CAT>TAT	p.H373Y	SENP5_uc011bty.1_Missense_Mutation_p.H373Y	NM_152699	NP_689912	Q96HI0	SENP5_HUMAN	SUMO1/sentrin specific peptidase 5	373					cell cycle|cell division|proteolysis	nucleolus	cysteine-type peptidase activity			breast(2)|lung(1)	3	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.14e-24)|all cancers(36;2.1e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.004)		AGAGCTGATTCATGACATCCC	0.443		NaN											0	0	0	0.058154	0	6	38				
DLG1	1739	broad.mit.edu	37	3	196792639	196792639	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr3:196792639C>G	uc003fxo.3	-	22	2363	c.2173G>C	c.(2173-2175)GAC>CAC	p.D725H	DLG1_uc011bub.1_Missense_Mutation_p.D621H|DLG1_uc011buc.1_Missense_Mutation_p.D609H|DLG1_uc011bud.1_Missense_Mutation_p.D408H|DLG1_uc003fxn.3_Missense_Mutation_p.D747H|DLG1_uc011bue.1_Missense_Mutation_p.D713H|DLG1_uc010ial.2_Missense_Mutation_p.D725H	NM_001098424	NP_001091894	Q12959	DLG1_HUMAN	discs, large homolog 1 isoform 1	725	Guanylate kinase-like.				actin filament organization|axon guidance|cell-cell adhesion|cortical actin cytoskeleton organization|endothelial cell proliferation|establishment or maintenance of cell polarity|interspecies interaction between organisms|mitotic cell cycle G1/S transition checkpoint|negative regulation of mitotic cell cycle|protein localization in plasma membrane|synaptic transmission|tight junction assembly	basolateral plasma membrane|cytosol|endoplasmic reticulum membrane|immunological synapse|MPP7-DLG1-LIN7 complex|nucleus|postsynaptic density|postsynaptic membrane|sarcolemma|tight junction	cytoskeletal protein binding|guanylate kinase activity|L27 domain binding|phosphatase binding|phosphoprotein phosphatase activity|potassium channel regulator activity|protein binding|protein C-terminus binding|protein kinase binding			ovary(3)	3	all_cancers(143;6.22e-10)|Ovarian(172;0.0418)|Breast(254;0.0589)	Lung NSC(153;0.133)	Epithelial(36;3.23e-24)|all cancers(36;2.15e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0148)		TTTATCCTGTCTTTCATAGGT	0.299		NaN											0	0	0	0.175082	0	12	42				
ZNF721	170960	broad.mit.edu	37	4	436766	436766	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr4:436766C>A	uc003gag.2	-	3	2181	c.1490G>T	c.(1489-1491)GGC>GTC	p.G497V	ABCA11P_uc003gac.2_Intron|ABCA11P_uc003gad.2_Intron|ABCA11P_uc011buv.1_Intron|ABCA11P_uc003gae.2_Intron|ABCA11P_uc010ibd.1_Intron|ZNF721_uc003gaf.3_Missense_Mutation_p.G529V|ZNF721_uc010ibe.2_Missense_Mutation_p.G485V	NM_133474	NP_597731	D9N162	D9N162_HUMAN	zinc finger protein 721	497						intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						GGGTTTCTCGCCAGTATGAAT	0.383		NaN											1	0	9.31168e-06	0.105934	9.54447e-06	11	41				
NMU	10874	broad.mit.edu	37	4	56475309	56475309	+	Missense_Mutation	SNP	A	A	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr4:56475309A>G	uc003hbc.2	-	4	363	c.257T>C	c.(256-258)ATG>ACG	p.M86T	NMU_uc003hbd.1_RNA|NMU_uc010igv.1_RNA|NMU_uc010igw.1_Missense_Mutation_p.M1T|NMU_uc010igx.1_RNA	NM_006681	NP_006672	P48645	NMU_HUMAN	neuromedin U precursor	86					neuropeptide signaling pathway	extracellular region					0	Lung NSC(11;0.00256)|all_epithelial(27;0.075)|Glioma(25;0.08)|all_neural(26;0.101)	all_hematologic(202;0.103)	LUSC - Lung squamous cell carcinoma(4;6.72e-08)|Lung(4;6.22e-07)|Epithelial(7;0.00559)	LUSC - Lung squamous cell carcinoma(721;0.0115)		TAGCATTCCCATAATCATAAA	0.358		NaN											0	0	0	0.139131	0	41	24				
EXOC1	55763	broad.mit.edu	37	4	56734667	56734667	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr4:56734667G>C	uc003hbe.1	+	5	739	c.581G>C	c.(580-582)AGA>ACA	p.R194T	EXOC1_uc003hbf.1_Missense_Mutation_p.R194T|EXOC1_uc003hbg.1_Missense_Mutation_p.R194T	NM_018261	NP_060731	Q9NV70	EXOC1_HUMAN	exocyst complex component 1 isoform 1	194					exocytosis|protein transport	exocyst	protein binding			ovary(2)|skin(2)|lung(1)|central_nervous_system(1)	6	Glioma(25;0.08)|all_neural(26;0.101)					AAATTGTCCAGAGAGCTGCAG	0.388		NaN											0	0	0	0.080935	0	9	49				
AFF1	4299	broad.mit.edu	37	4	88052994	88052994	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr4:88052994G>C	uc003hqj.3	+	17	3537	c.3130G>C	c.(3130-3132)GAG>CAG	p.E1044Q	AFF1_uc011ccz.1_Missense_Mutation_p.E1051Q|AFF1_uc003hqk.3_Missense_Mutation_p.E1044Q|AFF1_uc011cda.1_Missense_Mutation_p.E682Q	NM_005935	NP_005926	P51825	AFF1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1044						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		GCCAACACAAGAGAAAATATT	0.308		NaN											0	0	0	0.150653	0	3	14				
NDST3	9348	broad.mit.edu	37	4	119158371	119158371	+	Missense_Mutation	SNP	A	A	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr4:119158371A>G	uc003ibx.2	+	10	2517	c.2114A>G	c.(2113-2115)TAC>TGC	p.Y705C	NDST3_uc011cgf.1_3'UTR	NM_004784	NP_004775	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan	705	Lumenal (Potential).|Heparan sulfate N-sulfotransferase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			large_intestine(1)	1						TACTCCTGGTACCAGGTAAGG	0.443		NaN											0	0	0	0.09319	0	8	35				
SPATA5	166378	broad.mit.edu	37	4	124177235	124177235	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr4:124177235G>A	uc003iez.3	+	15	2478	c.2405G>A	c.(2404-2406)AGA>AAA	p.R802K		NM_145207	NP_660208	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5	802					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity				0						GCAGCAACAAGAAGGGAAATA	0.438		NaN											0	0	0	0.139131	0	42	15				
NAA15	80155	broad.mit.edu	37	4	140299981	140299981	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr4:140299981G>A	uc003ihu.1	+	17	2384	c.2128G>A	c.(2128-2130)GAG>AAG	p.E710K		NM_057175	NP_476516	Q9BXJ9	NAA15_HUMAN	NMDA receptor regulated 1	710					angiogenesis|cell differentiation|N-terminal protein amino acid acetylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|transcription factor complex	protein binding			ovary(1)|skin(1)	2						CTGGCTTCATGAGTGTATGAT	0.328		NaN											0	0	0	0.108266	0	20	14				
ADAM29	11086	broad.mit.edu	37	4	175896737	175896737	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr4:175896737C>A	uc003iuc.2	+	5	731	c.61C>A	c.(61-63)CAG>AAG	p.Q21K	ADAM29_uc003iud.2_Missense_Mutation_p.Q21K|ADAM29_uc010irr.2_Missense_Mutation_p.Q21K|ADAM29_uc011cki.1_Missense_Mutation_p.Q21K	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	21					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TGGACACATCCAGGATGAGCA	0.507		NaN											1	0	1.96895e-08	0.076483	2.03086e-08	20	75				
ODZ3	55714	broad.mit.edu	37	4	183245337	183245337	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr4:183245337C>T	uc003ivd.1	+	1	201	c.164C>T	c.(163-165)TCG>TTG	p.S55L	ODZ3_uc010irv.1_Missense_Mutation_p.S55L	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	55	Cytoplasmic (Potential).|Teneurin N-terminal.				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		CATGATTCCTCGCGGCTGCTT	0.483		NaN											0	0	0	0.069288	0	20	57				
SEMA5A	9037	broad.mit.edu	37	5	9190395	9190395	+	Silent	SNP	G	G	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:9190395G>T	uc003jek.2	-	11	1969	c.1257C>A	c.(1255-1257)ATC>ATA	p.I419I		NM_003966	NP_003957	Q13591	SEM5A_HUMAN	semaphorin 5A precursor	419	Sema.|Extracellular (Potential).				cell adhesion|cell-cell signaling	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)	2						CCAAATAGATGATGTGGACGA	0.498		NaN											1	0	0.000442599	0.058154	0.000446685	8	34				
NUP155	9631	broad.mit.edu	37	5	37292081	37292081	+	Missense_Mutation	SNP	G	G	C	rs140076285	byFrequency	TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:37292081G>C	uc003jku.1	-	35	4215	c.4097C>G	c.(4096-4098)TCT>TGT	p.S1366C	NUP155_uc003jkt.1_Missense_Mutation_p.S1307C|NUP155_uc010iuz.1_Missense_Mutation_p.S1302C	NM_153485	NP_705618	O75694	NU155_HUMAN	nucleoporin 155kDa isoform 1	1366					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			ovary(1)	1	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CGAGCTCATAGACTGGAGCTC	0.363		NaN											0	0	0	0.055883	0	18	47				
MAP1B	4131	broad.mit.edu	37	5	71494257	71494257	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:71494257C>G	uc003kbw.3	+	5	5316	c.5075C>G	c.(5074-5076)TCT>TGT	p.S1692C	MAP1B_uc010iyw.1_Missense_Mutation_p.S1709C|MAP1B_uc010iyx.1_Missense_Mutation_p.S1566C|MAP1B_uc010iyy.1_Missense_Mutation_p.S1566C	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1692						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		TACAGTCCTTCTGACATGCAG	0.488		NaN											0	0	0	0.183431	0	33	16				
TNPO1	3842	broad.mit.edu	37	5	72189254	72189254	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:72189254G>A	uc003kck.3	+	17	2094	c.1947G>A	c.(1945-1947)ATG>ATA	p.M649I	TNPO1_uc011csj.1_Missense_Mutation_p.M599I|TNPO1_uc003kch.2_Missense_Mutation_p.M641I|TNPO1_uc003kci.3_Missense_Mutation_p.M641I|TNPO1_uc003kcg.3_Missense_Mutation_p.M641I	NM_002270	NP_002261	Q92973	TNPO1_HUMAN	transportin 1 isoform 1	649					interspecies interaction between organisms|mRNA metabolic process|protein import into nucleus, translocation	cytosol|nucleus	nuclear localization sequence binding|protein binding|protein transporter activity			skin(3)|urinary_tract(1)|ovary(1)|kidney(1)|central_nervous_system(1)	7		Lung NSC(167;0.0053)|Ovarian(174;0.0175)		OV - Ovarian serous cystadenocarcinoma(47;6.14e-54)		AAGATTTTATGATAGTGGCTC	0.378		NaN											0	0	0	0.184627	0	4	25				
CMYA5	202333	broad.mit.edu	37	5	79026793	79026793	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:79026793G>A	uc003kgc.2	+	2	2277	c.2205G>A	c.(2203-2205)GAG>GAA	p.E735E		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	735						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		CATCAGAAGAGAAGGAAGACA	0.463		NaN											0	0	0	0.175082	0	13	49				
GPR98	84059	broad.mit.edu	37	5	90078972	90078972	+	Silent	SNP	A	A	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:90078972A>G	uc003kju.2	+	66	13359	c.13263A>G	c.(13261-13263)CCA>CCG	p.P4421P	GPR98_uc003kjt.2_Silent_p.P2127P|GPR98_uc003kjw.2_Silent_p.P82P	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	4421	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		TCATGATCCCAGTGGTGAGGC	0.448		NaN											0	0	0	0.139131	0	43	168				
CAST	831	broad.mit.edu	37	5	96090429	96090429	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:96090429G>A	uc003klz.1	+	20	1607	c.1445G>A	c.(1444-1446)AGA>AAA	p.R482K	CAST_uc003klt.2_Missense_Mutation_p.R469K|CAST_uc003klu.2_Missense_Mutation_p.R565K|CAST_uc003klv.2_Missense_Mutation_p.R543K|CAST_uc003klw.2_Missense_Mutation_p.R546K|CAST_uc003klx.2_Missense_Mutation_p.R524K|CAST_uc003kly.2_Missense_Mutation_p.R530K|CAST_uc011cuo.1_Missense_Mutation_p.R528K|CAST_uc011cuq.1_Missense_Mutation_p.R330K|CAST_uc011cur.1_Missense_Mutation_p.R468K|CAST_uc011cus.1_Missense_Mutation_p.R469K|CAST_uc003kma.1_Missense_Mutation_p.R441K|CAST_uc011cut.1_Missense_Mutation_p.R410K|CAST_uc003kmb.2_Missense_Mutation_p.R428K|CAST_uc003kmc.2_Missense_Mutation_p.R482K|CAST_uc003kmd.2_Missense_Mutation_p.R460K|CAST_uc003kme.2_Missense_Mutation_p.R441K|CAST_uc003kmf.2_Missense_Mutation_p.R447K|CAST_uc003kmh.2_Missense_Mutation_p.R197K|CAST_uc010jbj.2_Missense_Mutation_p.R197K|CAST_uc010jbk.2_Missense_Mutation_p.R197K|CAST_uc010jbl.1_Missense_Mutation_p.R205K|CAST_uc003kmi.2_RNA|CAST_uc003kmj.2_Missense_Mutation_p.R205K|CAST_uc003kmk.2_5'Flank	NM_001042443	NP_001035908	P20810	ICAL_HUMAN	calpastatin isoform i	482	Inhibitory domain 3.						calcium-dependent cysteine-type endopeptidase inhibitor activity|protein binding			central_nervous_system(3)|ovary(1)|kidney(1)	5		all_cancers(142;5.27e-07)|all_epithelial(76;8.21e-10)|all_lung(232;0.000396)|Lung NSC(167;0.000539)|Ovarian(225;0.024)|Colorectal(57;0.0341)|Breast(839;0.244)		all cancers(79;6.85e-15)		CCTGATTATAGATTAGAAGAG	0.348		NaN											0	0	0	0.047766	0	7	30				
PCDHB1	29930	broad.mit.edu	37	5	140431442	140431442	+	Silent	SNP	T	T	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:140431442T>C	uc003lik.1	+	1	464	c.387T>C	c.(385-387)AAT>AAC	p.N129N		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	129	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TCAATGACAATGCCCCAGTTT	0.542		NaN											0	0	0	0.09319	0	11	15				
PCDHGA10	56106	broad.mit.edu	37	5	140794089	140794089	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:140794089C>T	uc003lkl.1	+	1	1347	c.1347C>T	c.(1345-1347)ATC>ATT	p.I449I	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc011day.1_Silent_p.I449I	NM_018913	NP_061736	Q9Y5H3	PCDGA_HUMAN	protocadherin gamma subfamily A, 10 isoform 1	449	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGCAGATATCAATGACAACC	0.498		NaN											0	0	0	0.163468	0	27	113				
PCDHGB7	56099	broad.mit.edu	37	5	140798381	140798381	+	Missense_Mutation	SNP	A	A	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:140798381A>T	uc003lkn.1	+	1	1100	c.955A>T	c.(955-957)ATA>TTA	p.I319L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkm.2_Missense_Mutation_p.I319L|PCDHGA11_uc003lko.1_5'Flank|PCDHGA11_uc003lkp.1_5'Flank|PCDHGA11_uc003lkq.1_5'Flank	NM_018927	NP_061750	Q9Y5F8	PCDGJ_HUMAN	protocadherin gamma subfamily B, 7 isoform 1	319	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TACGATAAACATAGAAGCAAA	0.398		NaN											0	0	0	0.02938	0	7	1				
PCDH1	5097	broad.mit.edu	37	5	141233836	141233836	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:141233836C>T	uc003llp.2	-	5	3602	c.3485G>A	c.(3484-3486)GGA>GAA	p.G1162E		NM_032420	NP_115796	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 2 precursor	Error:Variant_position_missing_in_Q08174_after_alignment					cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		CTCCTGCCCTCCTCGGTCCTG	0.677		NaN											0	0	0	0.02938	0	6	12				
PCDH1	5097	broad.mit.edu	37	5	141244913	141244913	+	Missense_Mutation	SNP	C	C	T	rs149443924		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:141244913C>T	uc003llq.2	-	3	1100	c.983G>A	c.(982-984)CGT>CAT	p.R328H	PCDH1_uc003llp.2_Missense_Mutation_p.R328H|PCDH1_uc011dbf.1_Missense_Mutation_p.R306H	NM_002587	NP_002578	Q08174	PCDH1_HUMAN	protocadherin 1 isoform 1 precursor	328	Extracellular (Potential).|Cadherin 3.				cell-cell signaling|homophilic cell adhesion|nervous system development	cell-cell junction|integral to plasma membrane	calcium ion binding			ovary(5)	5		Lung NSC(810;0.027)|all_lung(500;0.0321)|all_hematologic(541;0.0433)|Prostate(461;0.0453)|Breast(839;0.128)|Lung SC(612;0.238)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;1.06e-05)		TCGAAGAAGACGCCTCACAAC	0.537		NaN											0	0	0	0.139131	0	44	44				
GPR151	134391	broad.mit.edu	37	5	145894746	145894746	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:145894746C>T	uc003lod.1	-	1	931	c.931G>A	c.(931-933)GAA>AAA	p.E311K		NM_194251	NP_919227	Q8TDV0	GP151_HUMAN	G protein-coupled receptor 151	311	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTGAACTCTTCCGACATCACA	0.478		NaN											0	0	0	0.02938	0	7	8				
SLU7	10569	broad.mit.edu	37	5	159831861	159831861	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr5:159831861C>T	uc003lyg.2	-	14	1574	c.1419G>A	c.(1417-1419)GAG>GAA	p.E473E		NM_006425	NP_006416	O95391	SLU7_HUMAN	step II splicing factor SLU7	473					alternative nuclear mRNA splicing, via spliceosome|nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|cytoplasm|nuclear speck|small nuclear ribonucleoprotein complex	pre-mRNA 3'-splice site binding|second spliceosomal transesterification activity|zinc ion binding			ovary(1)	1	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCCCAGTTATCTCATTTATAA	0.348		NaN											0	0	0	0.11911	0	11	11				
MRS2	57380	broad.mit.edu	37	6	24416692	24416692	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:24416692G>C	uc003neb.2	+	7	909	c.787G>C	c.(787-789)GAG>CAG	p.E263Q	MRS2_uc003nea.2_Missense_Mutation_p.E263Q|MRS2_uc011djl.1_Missense_Mutation_p.E266Q|MRS2_uc011djm.1_RNA|MRS2_uc011djn.1_Missense_Mutation_p.E213Q|MRS2_uc003nec.2_Missense_Mutation_p.E140Q	NM_020662	NP_065713	Q9HD23	MRS2_HUMAN	MRS2-like, magnesium homeostasis factor	263	Mitochondrial matrix (Potential).				ion transport	integral to membrane|mitochondrial inner membrane					0						GGATGAGGAAGAGTTGCTAGA	0.294		NaN											0	0	0	0.139131	0	41	7				
SLC26A8	116369	broad.mit.edu	37	6	35928812	35928812	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:35928812G>C	uc003olm.2	-	13	1637	c.1526C>G	c.(1525-1527)TCA>TGA	p.S509*	SLC26A8_uc010jwa.2_RNA|SLC26A8_uc003olk.2_Nonsense_Mutation_p.S91*|SLC26A8_uc003oln.2_Nonsense_Mutation_p.S509*|SLC26A8_uc003oll.2_Nonsense_Mutation_p.S404*	NM_052961	NP_443193	Q96RN1	S26A8_HUMAN	solute carrier family 26, member 8 isoform a	509	Helical; (Potential).				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			ovary(2)	2						AGAAACTACTGAGATAATTAG	0.413		NaN											0	0	0	0.038147	0	6	20				
CRIP3	401262	broad.mit.edu	37	6	43273792	43273792	+	Missense_Mutation	SNP	T	T	C	rs139840752	by1000genomes	TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:43273792T>C	uc010jyn.1	-	7	566	c.566A>G	c.(565-567)CAT>CGT	p.H189R	CRIP3_uc003ouu.1_Intron	NM_206922	NP_996805	Q6Q6R5	CRIP3_HUMAN	cysteine-rich protein 3	189						cytoplasm	zinc ion binding			skin(1)	1			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			GTGTCTGGGATGGGGCTGCCC	0.557		NaN											0	0	0	0.139131	0	119	27				
CLIC5	53405	broad.mit.edu	37	6	45922939	45922939	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:45922939G>A	uc003oxv.3	-	2	689	c.583C>T	c.(583-585)CAG>TAG	p.Q195*	CLIC5_uc003oxu.3_Nonsense_Mutation_p.Q36*|CLIC5_uc003oxx.2_Nonsense_Mutation_p.Q36*	NM_001114086	NP_001107558	Q9NZA1	CLIC5_HUMAN	chloride intracellular channel 5 isoform a	195	Helical; Note=After insertion into the membrane; (Potential).				female pregnancy	actin cytoskeleton|cell cortex|chloride channel complex|Golgi apparatus|Golgi apparatus|insoluble fraction|microtubule organizing center	protein binding|voltage-gated chloride channel activity			ovary(1)|skin(1)	2						AAGAGGCGCTGAGAGAAAGGA	0.478		NaN											0	0	0	0.189662	0	15	11				
KCNQ5	56479	broad.mit.edu	37	6	73843246	73843246	+	Silent	SNP	C	C	T	rs139916334		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:73843246C>T	uc003pgk.2	+	10	1697	c.1350C>T	c.(1348-1350)ACC>ACT	p.T450T	KCNQ5_uc011dyh.1_Silent_p.T469T|KCNQ5_uc011dyi.1_Silent_p.T460T|KCNQ5_uc010kat.2_Silent_p.T441T|KCNQ5_uc011dyj.1_Intron|KCNQ5_uc011dyk.1_Silent_p.T200T	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	450					protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		CCCCAAGCACCGACATCACAG	0.587		NaN											0	0	0	0.139131	0	47	56				
MANEA	79694	broad.mit.edu	37	6	96054015	96054015	+	Missense_Mutation	SNP	A	A	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:96054015A>G	uc003poo.1	+	5	1263	c.1123A>G	c.(1123-1125)AAC>GAC	p.N375D		NM_024641	NP_078917	Q5SRI9	MANEA_HUMAN	mannosidase, endo-alpha	375	Catalytic (Probable).|Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	glycoprotein endo-alpha-1,2-mannosidase activity			ovary(2)|breast(1)	3		all_cancers(76;1.01e-06)|Acute lymphoblastic leukemia(125;3.58e-09)|all_hematologic(75;1.22e-06)|all_epithelial(107;0.00433)|Colorectal(196;0.0341)		BRCA - Breast invasive adenocarcinoma(108;0.148)		AAACACTCGGAACCGAATCAA	0.413		NaN											0	0	0	0.139131	0	47	39				
NUS1	116150	broad.mit.edu	37	6	118028140	118028140	+	Missense_Mutation	SNP	C	C	T	rs150953098		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:118028140C>T	uc003pxw.2	+	5	1061	c.844C>T	c.(844-846)CGT>TGT	p.R282C		NM_138459	NP_612468	Q96E22	NGBR_HUMAN	nuclear undecaprenyl pyrophosphate synthase 1	282	Cytoplasmic (Potential).				angiogenesis|cell differentiation	integral to membrane	receptor activity|transferase activity, transferring alkyl or aryl (other than methyl) groups			central_nervous_system(1)	1		all_cancers(87;0.0395)|all_epithelial(87;0.0301)		GBM - Glioblastoma multiforme(226;0.02)|OV - Ovarian serous cystadenocarcinoma(136;0.115)|all cancers(137;0.146)		CTCTGCCCTTCGTCAATATGC	0.433		NaN											0	0	0	0.108266	0	20	28				
PTPRK	5796	broad.mit.edu	37	6	128312003	128312003	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:128312003C>G	uc003qbk.2	-	21	3371	c.3004G>C	c.(3004-3006)GAT>CAT	p.D1002H	PTPRK_uc003qbj.2_Missense_Mutation_p.D1003H|PTPRK_uc010kfc.2_Missense_Mutation_p.D1009H|PTPRK_uc011ebu.1_Missense_Mutation_p.D1025H	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	1002	Tyrosine-protein phosphatase 1.|Cytoplasmic (Potential).				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		ACTTCAGTATCATCAGGCCAA	0.348		NaN											0	0	0	0.146539	0	12	47				
SYNE1	23345	broad.mit.edu	37	6	152462392	152462392	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:152462392C>G	uc010kiw.2	-	139	25794	c.25192G>C	c.(25192-25194)GAG>CAG	p.E8398Q	SYNE1_uc010kiv.2_Missense_Mutation_p.E2922Q|SYNE1_uc003qos.3_Missense_Mutation_p.E2922Q|SYNE1_uc003qot.3_Missense_Mutation_p.E8350Q|SYNE1_uc003qou.3_Missense_Mutation_p.E8398Q|SYNE1_uc003qop.3_Missense_Mutation_p.E583Q|SYNE1_uc011eez.1_Missense_Mutation_p.E600Q|SYNE1_uc003qoq.3_Missense_Mutation_p.E600Q|SYNE1_uc003qor.3_Missense_Mutation_p.E1321Q	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	8398	Potential.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AGGCTCTCCTCTTCCTCCTTC	0.488		NaN								HNSCC(10;0.0054)			0	0	0	0.139131	0	58	16				
SYNE1	23345	broad.mit.edu	37	6	152690184	152690184	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:152690184G>C	uc010kiw.2	-	61	10332	c.9730C>G	c.(9730-9732)CAA>GAA	p.Q3244E	SYNE1_uc003qot.3_Missense_Mutation_p.Q3251E|SYNE1_uc003qou.3_Missense_Mutation_p.Q3244E|SYNE1_uc010kja.1_5'UTR|SYNE1_uc003qov.2_Missense_Mutation_p.Q322E	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3244	Spectrin 6.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CTGGCAGCTTGTCCTTCCCAC	0.498		NaN								HNSCC(10;0.0054)			0	0	0	0.058154	0	9	34				
INTS1	26173	broad.mit.edu	37	7	1523488	1523488	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:1523488G>A	uc003skn.2	-	26	3532	c.3431C>T	c.(3430-3432)TCG>TTG	p.S1144L	INTS1_uc003skp.1_Missense_Mutation_p.S491L	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	1144					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		CTGAGACTCCGACTGTGGGAA	0.647		NaN											0	0	0	0.189662	0	17	78				
SDK1	221935	broad.mit.edu	37	7	3998602	3998602	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:3998602C>T	uc003smx.2	+	8	1329	c.1190C>T	c.(1189-1191)TCA>TTA	p.S397L		NM_152744	NP_689957	Q7Z5N4	SDK1_HUMAN	sidekick 1 precursor	397	Ig-like C2-type 4.				cell adhesion	integral to membrane				large_intestine(3)|ovary(2)|skin(1)	6		all_cancers(1;0.127)|Ovarian(82;0.0177)|Myeloproliferative disorder(862;0.194)		UCEC - Uterine corpus endometrioid carcinoma (126;0.121)|OV - Ovarian serous cystadenocarcinoma(56;9.65e-15)		AGTCGGATTTCAGCTGAAGTA	0.468		NaN											0	0	0	0.069288	0	17	71				
C7orf26	79034	broad.mit.edu	37	7	6629998	6629998	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:6629998C>T	uc003sqo.1	+	1	84	c.84C>T	c.(82-84)TTC>TTT	p.F28F	uc011jwy.1_5'Flank|C7orf26_uc003sqp.1_Silent_p.F28F|C7orf26_uc003sqq.1_5'UTR	NM_024067	NP_076972	Q96N11	CG026_HUMAN	hypothetical protein LOC79034	28										ovary(1)	1		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0986)		ACATCTACTTCAGCAGCCAGC	0.622		NaN											0	0	0	0.175082	0	15	25				
C1GALT1	56913	broad.mit.edu	37	7	7278084	7278084	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:7278084G>C	uc010ktn.2	+	3	642	c.419G>C	c.(418-420)AGA>ACA	p.R140T	C1GALT1_uc003sra.2_Missense_Mutation_p.R140T|C1GALT1_uc010kto.1_Missense_Mutation_p.R140T	NM_020156	NP_064541	Q9NS00	C1GLT_HUMAN	core 1 synthase,	140	Lumenal (Potential).				angiogenesis|cell differentiation|kidney development	integral to membrane	glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity|metal ion binding				0				UCEC - Uterine corpus endometrioid carcinoma (126;0.177)		AAAGAAGGCAGAGATCAACTA	0.373		NaN											0	0	0	0.080935	0	8	26				
DFNA5	1687	broad.mit.edu	37	7	24749946	24749946	+	Silent	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:24749946G>C	uc010kus.1	-	6	847	c.759C>G	c.(757-759)GTC>GTG	p.V253V	DFNA5_uc003swz.2_Silent_p.V89V|DFNA5_uc003sxa.1_Silent_p.V253V|DFNA5_uc010kut.1_Silent_p.V89V	NM_001127453	NP_001120925	O60443	DFNA5_HUMAN	deafness, autosomal dominant 5 protein isoform	253					sensory perception of sound					ovary(1)	1						GGTCCAGGTAGACAGAGTCAA	0.473		NaN											0	0	0	0.146539	0	14	61				
URGCP	55665	broad.mit.edu	37	7	43916935	43916935	+	Silent	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:43916935G>C	uc003tiw.2	-	6	2184	c.2127C>G	c.(2125-2127)CTC>CTG	p.L709L	URGCP_uc003tiu.2_Silent_p.L666L|URGCP_uc003tiv.2_Silent_p.L634L|URGCP_uc003tix.2_Silent_p.L700L|URGCP_uc003tiy.2_Silent_p.L666L|URGCP_uc003tiz.2_Silent_p.L666L|URGCP_uc011kbj.1_Silent_p.L666L	NM_001077663	NP_001071131	Q8TCY9	URGCP_HUMAN	up-regulated gene 4 isoform 3	709					cell cycle	centrosome|nucleus	GTP binding			ovary(2)|liver(1)|skin(1)	4						ACATGGTGTTGAGGAGTGTGG	0.627		NaN											0	0	0	0.203993	0	31	123				
C7orf57	136288	broad.mit.edu	37	7	48080989	48080989	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:48080989G>A	uc003toh.3	+	3	326	c.114G>A	c.(112-114)GCG>GCA	p.A38A	C7orf57_uc003toi.3_5'UTR	NM_001100159	NP_001093629	Q8NEG2	CG057_HUMAN	hypothetical protein LOC136288	38										ovary(1)	1						CCCCACCAGCGTCCCAGATCC	0.537		NaN											0	0	0	0.139131	0	36	49				
C7orf42	55069	broad.mit.edu	37	7	66418353	66418353	+	Silent	SNP	G	G	A	rs149604295		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:66418353G>A	uc003tvk.2	+	6	1185	c.921G>A	c.(919-921)GAG>GAA	p.E307E	C7orf42_uc010lah.2_RNA|C7orf42_uc003tvl.2_Silent_p.E307E	NM_017994	NP_060464	Q9NWD8	CG042_HUMAN	hypothetical protein LOC55069	307						integral to membrane				ovary(1)	1						TTTGTCCCGAGAAGGTGAGCG	0.453		NaN											0	0	0	0.124865	0	35	180				
HIP1	3092	broad.mit.edu	37	7	75190679	75190679	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:75190679C>G	uc003uds.1	-	13	1186	c.1145G>C	c.(1144-1146)AGA>ACA	p.R382T	HIP1_uc011kfz.1_Missense_Mutation_p.R259T	NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	382	Potential.				activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						ACTGATCTCTCTGTATAGTCG	0.443		NaN	T	PDGFRB	CMML								0	0	0	0.139131	0	46	85				
DTX2	113878	broad.mit.edu	37	7	76112191	76112191	+	Missense_Mutation	SNP	G	G	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:76112191G>T	uc003uff.3	+	5	1191	c.635G>T	c.(634-636)GGC>GTC	p.G212V	DTX2_uc011kgk.1_Missense_Mutation_p.G121V|DTX2_uc003ufg.3_Missense_Mutation_p.G212V|DTX2_uc003ufh.3_Missense_Mutation_p.G212V|DTX2_uc003ufj.3_Missense_Mutation_p.G212V	NM_020892	NP_065943	Q86UW9	DTX2_HUMAN	deltex 2 isoform a	212					Notch signaling pathway	cytoplasm|nucleus	protein binding|zinc ion binding			ovary(1)|skin(1)	2						CCCGTGTCAGGCCGCTACCGC	0.662		NaN											1	0	1.00246e-47	0.139131	1.07454e-47	45	444				
FZD1	8321	broad.mit.edu	37	7	90895017	90895017	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:90895017C>T	uc003ula.2	+	1	1235	c.822C>T	c.(820-822)TTC>TTT	p.F274F		NM_003505	NP_003496	Q9UP38	FZD1_HUMAN	frizzled 1 precursor	274	Extracellular (Potential).				autocrine signaling|axonogenesis|brain development|canonical Wnt receptor signaling pathway involved in mesenchymal stem cell differentiation|canonical Wnt receptor signaling pathway involved in osteoblast differentiation|embryo development|epithelial cell differentiation|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|lung alveolus development|negative regulation of BMP signaling pathway|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|response to drug|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cell surface|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|receptor binding|Wnt receptor activity|Wnt-protein binding				0	all_cancers(62;3.1e-10)|all_epithelial(64;1.66e-08)|Breast(17;0.000635)|Lung NSC(181;0.153)|all_lung(186;0.154)|all_hematologic(106;0.215)		STAD - Stomach adenocarcinoma(171;0.0134)			GAGGCAAGTTCTCCTGCCCGC	0.692		NaN											0	0	0	0.080935	0	11	8				
COPS6	10980	broad.mit.edu	37	7	99686983	99686983	+	Silent	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:99686983C>G	uc003usu.2	+	2	178	c.147C>G	c.(145-147)CTC>CTG	p.L49L	COPS6_uc011kjf.1_Silent_p.L49L	NM_006833	NP_006824	Q7L5N1	CSN6_HUMAN	COP9 signalosome subunit 6	49	MPN.				cullin deneddylation|interspecies interaction between organisms	cytoplasm|signalosome	protein binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)		STAD - Stomach adenocarcinoma(171;0.129)			TTGTCATTCTCAACATCTCAG	0.592		NaN											0	0	0	0.139131	0	134	175				
SRRT	51593	broad.mit.edu	37	7	100483362	100483362	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:100483362C>G	uc003uwy.2	+	12	1626	c.1358C>G	c.(1357-1359)TCA>TGA	p.S453*	SRRT_uc010lhl.1_Nonsense_Mutation_p.S452*|SRRT_uc003uxa.2_Nonsense_Mutation_p.S452*|SRRT_uc003uwz.2_Nonsense_Mutation_p.S453*	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	453					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						GTGGCGCTCTCAGAGCCCCAG	0.537		NaN											0	0	0	0.02938	0	5	21				
LRRC4	64101	broad.mit.edu	37	7	127670203	127670203	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:127670203G>C	uc003vmk.2	-	2	628	c.491C>G	c.(490-492)TCT>TGT	p.S164C	SND1_uc003vmi.2_Intron|SND1_uc010lle.2_Intron	NM_022143	NP_071426	Q9HBW1	LRRC4_HUMAN	leucine rich repeat containing 4 precursor	164	LRR 4.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic membrane				large_intestine(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4				Lung(243;0.124)		GAAGGCGTAAGAGGGGATGCT	0.572		NaN											0	0	0	0.214465	0	30	135				
CLCN1	1180	broad.mit.edu	37	7	143039166	143039166	+	Missense_Mutation	SNP	C	C	G	rs143825889		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:143039166C>G	uc003wcr.1	+	15	1814	c.1727C>G	c.(1726-1728)TCT>TGT	p.S576C	CLCN1_uc011ktc.1_Missense_Mutation_p.S188C	NM_000083	NP_000074	P35523	CLCN1_HUMAN	chloride channel 1, skeletal muscle	576	Cytoplasmic (By similarity).				muscle contraction	chloride channel complex|integral to plasma membrane	voltage-gated chloride channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Melanoma(164;0.205)					CTGCAGCCCTCTCTCTATGAC	0.527		NaN											0	0	0	0.09836	0	36	47				
OR2F1	26211	broad.mit.edu	37	7	143657918	143657918	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:143657918G>A	uc003wds.1	+	1	899	c.855G>A	c.(853-855)CTG>CTA	p.L285L		NM_012369	NP_036501	Q13607	OR2F1_HUMAN	olfactory receptor, family 2, subfamily F,	285	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3	Melanoma(164;0.0903)					CACCAATGCTGAACCCCATGA	0.453		NaN											0	0	0	0.153744	0	26	46				
ZNF425	155054	broad.mit.edu	37	7	148800826	148800826	+	Silent	SNP	G	G	A	rs142180575		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:148800826G>A	uc003wfj.2	-	4	2210	c.2137C>T	c.(2137-2139)CTG>TTG	p.L713L		NM_001001661	NP_001001661	Q6IV72	ZN425_HUMAN	zinc finger protein 425	713	C2H2-type 18.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			TGAAGGCACAGATGGGCCTTC	0.552		NaN											0	0	0	0.062417	0	19	27				
ZNF425	155054	broad.mit.edu	37	7	148801778	148801778	+	Silent	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr7:148801778G>A	uc003wfj.2	-	4	1258	c.1185C>T	c.(1183-1185)TTC>TTT	p.F395F		NM_001001661	NP_001001661	Q6IV72	ZN425_HUMAN	zinc finger protein 425	395	C2H2-type 7.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			TCTTGTAGATGAATTTCCTGC	0.532		NaN											0	0	0	0.139131	0	55	92				
CTSB	1508	broad.mit.edu	37	8	11708405	11708405	+	Missense_Mutation	SNP	G	G	C	rs144771892		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:11708405G>C	uc003wum.2	-	6	621	c.297C>G	c.(295-297)ATC>ATG	p.I99M	CTSB_uc003wul.2_5'Flank|CTSB_uc011kxl.1_Intron|CTSB_uc003wun.2_Missense_Mutation_p.I99M|CTSB_uc003wuo.2_Missense_Mutation_p.I99M|CTSB_uc003wup.2_Missense_Mutation_p.I99M|CTSB_uc003wuq.2_Missense_Mutation_p.I99M|CTSB_uc010lsc.2_Nonsense_Mutation_p.S15*|CTSB_uc003wur.2_Missense_Mutation_p.I99M|CTSB_uc003wus.1_Missense_Mutation_p.I99M|CTSB_uc003wut.1_Missense_Mutation_p.I99M|CTSB_uc003wuu.2_5'Flank	NM_147780	NP_680090	P07858	CATB_HUMAN	cathepsin B preproprotein	99					proteolysis|regulation of apoptosis|regulation of catalytic activity	lysosome|melanosome	cysteine-type endopeptidase activity				0	all_epithelial(15;0.205)		STAD - Stomach adenocarcinoma(15;0.00546)	COAD - Colon adenocarcinoma(149;0.184)		CCTGGTCTCTGATCTCTTTGA	0.572		NaN											0	0	0	0.132662	0	10	14				
TNFRSF10A	8797	broad.mit.edu	37	8	23082521	23082521	+	Silent	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:23082521C>G	uc003xda.2	-	1	119	c.54G>C	c.(52-54)CCG>CCC	p.P18P	uc003xdb.1_5'Flank	NM_003844	NP_003835	O00220	TR10A_HUMAN	tumor necrosis factor receptor superfamily,	18					activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors		caspase activator activity|death receptor activity|TRAIL binding|transcription factor binding			central_nervous_system(3)|ovary(2)|skin(1)	6		Prostate(55;0.0421)|Breast(100;0.14)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)		TCCCGGGATTCGGAGTCACTG	0.632		NaN											0	0	0	0.062417	0	14	16				
ANK1	286	broad.mit.edu	37	8	41583422	41583422	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:41583422C>T	uc003xok.2	-	6	553	c.469G>A	c.(469-471)GAG>AAG	p.E157K	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoi.2_Missense_Mutation_p.E157K|ANK1_uc003xoj.2_Missense_Mutation_p.E157K|ANK1_uc003xol.2_Missense_Mutation_p.E157K|ANK1_uc003xom.2_Missense_Mutation_p.E190K	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	157	ANK 4.|89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			ACGACGTTCTCATGGCCCTGC	0.662		NaN											0	0	0	0.183431	0	26	18				
PI15	51050	broad.mit.edu	37	8	75737599	75737599	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:75737599G>A	uc003yal.2	+	2	294	c.115G>A	c.(115-117)GAT>AAT	p.D39N	uc003yak.1_Intron|PI15_uc003yam.2_Missense_Mutation_p.D39N	NM_015886	NP_056970	O43692	PI15_HUMAN	protease inhibitor 15 preproprotein	39						extracellular region	peptidase inhibitor activity			central_nervous_system(2)|ovary(1)	3	Breast(64;0.137)		BRCA - Breast invasive adenocarcinoma(89;0.104)|Epithelial(68;0.118)			TAATTTCACTGATATTGAAGC	0.488		NaN											0	0	0	0.139131	0	50	50				
STMN2	11075	broad.mit.edu	37	8	80549051	80549051	+	Missense_Mutation	SNP	A	A	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:80549051A>G	uc003ybj.2	+	2	85	c.34A>G	c.(34-36)ATG>GTG	p.M12V	STMN2_uc010lzp.2_RNA|STMN2_uc011lfn.1_Missense_Mutation_p.M12V	NM_007029	NP_008960	Q93045	STMN2_HUMAN	superiorcervical ganglia, neural specific 10	12	Membrane attachment (Potential).				intracellular signal transduction|negative regulation of microtubule depolymerization|negative regulation of microtubule polymerization|negative regulation of neuron projection development|neuron differentiation|positive regulation of microtubule depolymerization|positive regulation of neuron projection development	axon|growth cone|membrane|membrane fraction|perinuclear region of cytoplasm|soluble fraction	protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(9;8.34e-05)		Epithelial(68;0.0229)|all cancers(69;0.0874)			CAAGGAAAAAATGAAGGAGCT	0.358		NaN											0	0	0	0.132662	0	11	33				
KCNV1	27012	broad.mit.edu	37	8	110984713	110984713	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:110984713C>T	uc003ynr.3	-	2	1107	c.765G>A	c.(763-765)GGG>GGA	p.G255G	KCNV1_uc010mcw.2_Silent_p.G255G	NM_014379	NP_055194	Q6PIU1	KCNV1_HUMAN	potassium channel, subfamily V, member 1	255	Helical; Name=Segment S2; (Potential).					voltage-gated potassium channel complex	ion channel inhibitor activity|potassium channel regulator activity|voltage-gated potassium channel activity			lung(1)|kidney(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;5.35e-13)			GGACAAACTCCCCGGTGAACC	0.522		NaN											0	0	0	0.160694	0	15	67				
SNTB1	6641	broad.mit.edu	37	8	121644785	121644785	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:121644785C>A	uc010mdg.2	-	3	1121	c.895G>T	c.(895-897)GAC>TAC	p.D299Y	SNTB1_uc003ype.2_Missense_Mutation_p.D299Y	NM_021021	NP_066301	Q13884	SNTB1_HUMAN	basic beta 1 syntrophin	299					muscle contraction	cell junction|cytoplasm|cytoskeleton|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|calmodulin binding			skin(5)	5	Lung NSC(37;4.46e-09)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)		STAD - Stomach adenocarcinoma(47;0.00503)			GTCAGCAGGTCATTAACGTTG	0.537		NaN											1	0	3.73988e-18	0.116897	3.96984e-18	24	67				
C8orf76	84933	broad.mit.edu	37	8	124238796	124238796	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:124238796C>T	uc003yqc.1	-	5	923	c.892G>A	c.(892-894)GAA>AAA	p.E298K	C8orf76_uc003yqd.2_Missense_Mutation_p.E266K	NM_032847	NP_116236	Q96K31	CH076_HUMAN	hypothetical protein LOC84933	298							binding			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			ATTTTATCTTCAATTTCCTGC	0.418		NaN											0	0	0	0.021553	0	4	26				
FLJ43860	389690	broad.mit.edu	37	8	142490016	142490016	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:142490016C>G	uc003ywi.2	-	8	1050	c.969G>C	c.(967-969)CAG>CAC	p.Q323H	FLJ43860_uc011ljs.1_RNA|FLJ43860_uc010meu.1_RNA	NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	hypothetical protein LOC389690	323							binding				0	all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			TCACCTCCCTCTGCTTGGGCC	0.592		NaN											0	0	0	0.11911	0	12	48				
GRINA	2907	broad.mit.edu	37	8	145066426	145066426	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:145066426C>T	uc003zan.1	+	5	873	c.707C>T	c.(706-708)GCC>GTC	p.A236V	GRINA_uc003zao.1_Missense_Mutation_p.A236V|GRINA_uc003zap.1_Missense_Mutation_p.A236V	NM_001009184	NP_001009184	Q7Z429	GRINA_HUMAN	glutamate receptor, ionotropic, N-methyl	236	Helical; (Potential).					integral to membrane				central_nervous_system(1)	1	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GTCCTGACCGCCAGCCTGTCG	0.627		NaN											0	0	0	0.055883	0	16	112				
HSF1	3297	broad.mit.edu	37	8	145535421	145535421	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr8:145535421C>T	uc003zbt.3	+	8	929	c.759C>T	c.(757-759)TAC>TAT	p.Y253Y	HSF1_uc003zbu.3_RNA	NM_005526	NP_005517	Q00613	HSF1_HUMAN	heat shock transcription factor 1	253	Regulatory domain.					cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;1.12e-39)|all cancers(56;9.11e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0547)|Colorectal(110;0.055)			CCAGCCTCTACGCCCCTGATG	0.672		NaN											0	0	0	0.193644	0	26	83				
DOCK8	81704	broad.mit.edu	37	9	339064	339064	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr9:339064C>T	uc003zgf.2	+	13	1593	c.1481C>T	c.(1480-1482)TCA>TTA	p.S494L	DOCK8_uc011lls.1_Missense_Mutation_p.S494L|DOCK8_uc010mgu.2_5'UTR|DOCK8_uc010mgv.2_Missense_Mutation_p.S426L|DOCK8_uc003zgg.2_Missense_Mutation_p.S426L|DOCK8_uc003zgh.2_RNA	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	494	DHR-1.				blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		TACAAAAGATCATCATCCTTA	0.398		NaN											0	0	0	0.150653	0	3	11				
IFNA4	3441	broad.mit.edu	37	9	21187385	21187385	+	Missense_Mutation	SNP	T	T	G			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr9:21187385T>G	uc003zon.2	-	1	214	c.146A>C	c.(145-147)CAT>CCT	p.H49P		NM_021068	NP_066546	P05014	IFNA4_HUMAN	interferon, alpha 4 precursor	49					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|interferon-alpha/beta receptor binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(5;2.69e-202)|Lung(24;2.26e-22)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)		GCAGGAGAAATGAGAGATTCT	0.517		NaN											0	0	0	0.086207	0	30	55				
OR13F1	138805	broad.mit.edu	37	9	107267429	107267429	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr9:107267429G>C	uc011lvm.1	+	1	886	c.886G>C	c.(886-888)GAG>CAG	p.E296Q		NM_001004485	NP_001004485	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F,	296	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)|skin(1)	3						ACGGAACAAAGAGGTGAAAGT	0.373		NaN											0	0	0	0.076483	0	20	4				
NUP188	23511	broad.mit.edu	37	9	131745215	131745215	+	Silent	SNP	C	C	T			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr9:131745215C>T	uc004bws.1	+	17	1726	c.1704C>T	c.(1702-1704)ATC>ATT	p.I568I	NUP188_uc004bwu.2_5'Flank	NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	568					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						TCAAACCCATCATTGATCTCG	0.502		NaN											0	0	0	0.139131	0	40	52				
GPR107	57720	broad.mit.edu	37	9	132889830	132889830	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr9:132889830G>A	uc004bze.2	+	18	1796	c.1569G>A	c.(1567-1569)TGG>TGA	p.W523*	GPR107_uc004bzb.2_Nonsense_Mutation_p.W286*|GPR107_uc004bzc.3_RNA|GPR107_uc011mbx.1_Nonsense_Mutation_p.W494*|GPR107_uc004bzd.2_Nonsense_Mutation_p.W475*|GPR107_uc004bzg.1_5'Flank	NM_001136557	NP_001130029	Q5VW38	GP107_HUMAN	G protein-coupled receptor 107 isoform 1	523						integral to membrane				upper_aerodigestive_tract(1)	1		Ovarian(14;0.000531)				CATTCCAGTGGAAGTGGCTCT	0.418		NaN											0	0	0	0.153744	0	25	12				
ZNF645	158506	broad.mit.edu	37	X	22291896	22291896	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chrX:22291896G>A	uc004dai.1	+	1	837	c.788G>A	c.(787-789)TGT>TAT	p.C263Y		NM_152577	NP_689790	Q8N7E2	ZN645_HUMAN	zinc finger protein 645	263	Pro-rich.					intracellular	zinc ion binding			lung(1)|pancreas(1)	2						TATCCTGAGTGTCAAAGTCAA	0.413		NaN											0	0	0	0.139131	0	55	70				
KDM6A	7403	broad.mit.edu	37	X	44949017	44949017	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chrX:44949017G>A	uc004dge.3	+	25	3953	c.3578G>A	c.(3577-3579)TGG>TAG	p.W1193*	KDM6A_uc011mkz.1_Nonsense_Mutation_p.W1245*|KDM6A_uc011mla.1_Nonsense_Mutation_p.W1148*|KDM6A_uc011mlb.1_Nonsense_Mutation_p.W1200*|KDM6A_uc011mlc.1_Nonsense_Mutation_p.W897*|KDM6A_uc011mld.1_Nonsense_Mutation_p.W832*	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	1193	JmjC.				histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						ATGGGTTCTTGGTGGCCCAAT	0.353		NaN	D|N|F|S		renal|oesophageal SCC|MM								0	0	0	0.069234	0	9	1		Valid		
HUWE1	10075	broad.mit.edu	37	X	53620499	53620499	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chrX:53620499G>C	uc004dsp.2	-	32	3968	c.3566C>G	c.(3565-3567)TCA>TGA	p.S1189*	HUWE1_uc004dsn.2_Nonsense_Mutation_p.S14*	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	1189					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						AGGCAAGTCTGAGTGTTCCAA	0.453		NaN											0	0	0	0.189662	0	18	25				
SNX27	81609	broad.mit.edu	37	1	151584734	151584735	+	In_Frame_Ins	INS	-	-	GGC			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:151584734_151584735insGGC	uc001eyn.1	+	1	73_74	c.57_58insGGC	c.(55-60)insGGC	p.25_26insG		NM_030918	NP_112180	Q96L92	SNX27_HUMAN	sorting nexin family member 27	25_26					cell communication|protein transport|signal transduction	cytosol|early endosome	phosphatidylinositol binding|protein binding			ovary(2)|central_nervous_system(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		LUSC - Lung squamous cell carcinoma(543;0.181)			GGAAcggaggtggcggcggcgg	0.441		NaN											NaN	NaN	NaN	NaN	NaN	10	20	---		---	---
BTG2	7832	broad.mit.edu	37	1	203276381	203276382	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08			AG	-	AG	AG		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr1:203276381_203276382delAG	uc001gzq.2	+	2	363_364	c.292_293delAG	c.(292-294)AGCfs	p.S98fs	FMOD_uc010pqi.1_Intron|uc009xao.1_5'Flank|uc001gzp.1_5'Flank|BTG2_uc009xap.1_RNA	NM_006763	NP_006754	P78543	BTG2_HUMAN	B-cell translocation gene 2	98					DNA repair|neuron projection development|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(1)|kidney(1)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.203)			GCTGCTGCCCAGCGAGCTGACC	0.644		NaN											NaN	NaN	NaN	NaN	NaN	34	93	---	Valid	---	---
PPFIA1	8500	broad.mit.edu	37	11	70194407	70194407	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr11:70194407delC	uc001opo.2	+	16	2242	c.2044delC	c.(2044-2046)CCCfs	p.P682fs	PPFIA1_uc001opn.1_Frame_Shift_Del_p.P682fs|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opq.1_RNA	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	682					cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			GAGCTCCATTCCCCCCTACCC	0.557		NaN											NaN	NaN	NaN	NaN	NaN	8	2895	---		---	---
SLFN12L	342615	broad.mit.edu	37	17	33806620	33806620	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr17:33806620delA	uc002hjn.2	-	3	1575	c.696delT	c.(694-696)TTTfs	p.F232fs		NM_001145027	NP_001138499			schlafen family member 12-like											ovary(1)	1						CTGTTCTGTTAAAAAAATCAG	0.368		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---		---	---
LPPR2	64748	broad.mit.edu	37	19	11473280	11473288	+	In_Frame_Del	DEL	GCGTGGTCC	GCGTGGTCC	-			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:11473280_11473288delGCGTGGTCC	uc002mre.1	+	7	1092_1100	c.755_763delGCGTGGTCC	c.(754-765)GGCGTGGTCCGC>GGC	p.VVR253del	LPPR2_uc002mrf.1_In_Frame_Del_p.VVR228del|LPPR2_uc010dxy.1_In_Frame_Del_p.VVR60del	NM_022737	NP_073574	Q96GM1	LPPR2_HUMAN	lipid phosphate phosphatase-related protein type	253_255	Helical; (Potential).					integral to membrane	phosphatidate phosphatase activity			large_intestine(1)	1						TTCCTGGTGGGCGTGGTCCGCGTGGCCGA	0.651		NaN											NaN	NaN	NaN	NaN	NaN	22	137	---		---	---
LILRB1	10859	broad.mit.edu	37	19	55146148	55146150	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr19:55146148_55146150delCTC	uc002qgj.2	+	11	1757_1759	c.1417_1419delCTC	c.(1417-1419)CTCdel	p.L479del	LILRB1_uc010erp.1_In_Frame_Del_p.L94del|LILRB1_uc002qgl.2_In_Frame_Del_p.L479del|LILRB1_uc002qgk.2_In_Frame_Del_p.L480del|LILRB1_uc002qgm.2_In_Frame_Del_p.L480del|LILRB1_uc010erq.2_In_Frame_Del_p.L463del|LILRB1_uc010err.2_RNA	NM_006669	NP_006660	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor,	479	Helical; (Potential).				regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity	p.L479del(1)		large_intestine(1)|ovary(1)|skin(1)	3				GBM - Glioblastoma multiforme(193;0.0188)		CAtcctactgctcctcctcctcc	0.458		NaN								HNSCC(37;0.09)			NaN	NaN	NaN	NaN	NaN	9	80	---		---	---
FOXC1	2296	broad.mit.edu	37	6	1611802	1611803	+	In_Frame_Ins	INS	-	-	GGC	rs71807729		TCGA-CU-A3KJ-01A-11D-A21A-08	TCGA-CU-A3KJ-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e22c6a44-4f8e-44eb-8ca8-dff0f2fc5575	e5b3d378-b7dd-458b-ac52-9892a5a571eb	g.chr6:1611802_1611803insGGC	uc003mtp.2	+	1	1122_1123	c.1122_1123insGGC	c.(1120-1125)insGGC	p.380_381insG		NM_001453	NP_001444	Q12948	FOXC1_HUMAN	forkhead box C1	380_381	Poly-Gly.				anti-apoptosis|artery morphogenesis|blood vessel remodeling|brain development|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|germ cell migration|glycosaminoglycan metabolic process|lacrimal gland development|lymphangiogenesis|metanephros development|negative regulation of mitotic cell cycle|neural crest cell fate commitment|Notch signaling pathway|odontogenesis of dentine-containing tooth|ossification|ovarian follicle development|paraxial mesodermal cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	nuclear heterochromatin|transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)	1	Ovarian(93;0.0733)	all_cancers(2;4.45e-07)|all_epithelial(2;4.33e-05)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		Epithelial(2;0.0904)|OV - Ovarian serous cystadenocarcinoma(45;0.095)|all cancers(2;0.168)		cgggcagctcgggcggcggcgg	0.49		NaN											NaN	NaN	NaN	NaN	NaN	4	5	---		---	---
