Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_by_all_platform	validation_method	validation_tumor_sample
LRRC47	57470	broad.mit.edu	37	1	3697775	3697775	+	Silent	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:3697775G>A	uc001akx.1	-	7	1657	c.1629C>T	c.(1627-1629)GAC>GAT	p.D543D		NM_020710	NP_065761	Q8N1G4	LRC47_HUMAN	leucine rich repeat containing 47	543					translation		phenylalanine-tRNA ligase activity|RNA binding			large_intestine(1)|ovary(1)	2	all_cancers(77;0.0375)|Ovarian(185;0.0634)|all_lung(157;0.208)|Lung NSC(156;0.21)	all_epithelial(116;1.34e-16)|all_lung(118;2.53e-06)|Lung NSC(185;0.00028)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.0743)|Ovarian(437;0.127)		Epithelial(90;5.49e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.43e-22)|GBM - Glioblastoma multiforme(42;3.69e-16)|Colorectal(212;1.21e-05)|COAD - Colon adenocarcinoma(227;5.87e-05)|Kidney(185;0.000367)|BRCA - Breast invasive adenocarcinoma(365;0.000704)|KIRC - Kidney renal clear cell carcinoma(229;0.00567)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.124)		GGGAGGGCCCGTCCTTTCCAG	0.572		NaN											0	0	0	0.00361	0	43	101				
TNFRSF1B	7133	broad.mit.edu	37	1	12251945	12251945	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:12251945G>A	uc001att.2	+	4	511	c.422G>A	c.(421-423)CGC>CAC	p.R141H	TNFRSF1B_uc001atu.2_5'UTR|TNFRSF1B_uc009vnk.2_RNA	NM_001066	NP_001057	P20333	TNR1B_HUMAN	tumor necrosis factor receptor 2 precursor	141	TNFR-Cys 3.|Extracellular (Potential).			R -> P (in Ref. 15; AAA63262).	apoptosis	extracellular region|integral to membrane|membrane raft|plasma membrane	tumor necrosis factor receptor activity			liver(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.249)	Lung NSC(185;8.72e-05)|all_lung(284;9.92e-05)|Renal(390;0.000147)|Colorectal(325;0.000584)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|Colorectal(212;5.52e-07)|COAD - Colon adenocarcinoma(227;0.000345)|BRCA - Breast invasive adenocarcinoma(304;0.000353)|Kidney(185;0.00102)|KIRC - Kidney renal clear cell carcinoma(229;0.00302)|STAD - Stomach adenocarcinoma(313;0.00815)|READ - Rectum adenocarcinoma(331;0.0284)	Etanercept(DB00005)|Infliximab(DB00065)	GCGCCGCTGCGCAAGTGCCGC	0.687		NaN											0	0	0	0.00361	0	69	59				
PDPN	10630	broad.mit.edu	37	1	13933692	13933692	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:13933692A>T	uc001avd.2	+	2	369	c.320A>T	c.(319-321)GAC>GTC	p.D107V	PDPN_uc001avc.2_Missense_Mutation_p.D107V|PDPN_uc009vob.2_5'UTR|PDPN_uc009voc.2_5'UTR|PDPN_uc001ave.2_5'UTR|PDPN_uc001avf.2_5'UTR	NM_006474	NP_006465	Q86YL7	PDPN_HUMAN	lung type-I cell membrane-associated	31	Extracellular (Potential).				cell morphogenesis|lymphangiogenesis|regulation of cell shape	filopodium membrane|integral to plasma membrane|lamellipodium membrane|microvillus membrane|ruffle membrane				ovary(2)	2	Ovarian(185;0.249)	all_lung(284;2.29e-05)|Lung NSC(185;4.37e-05)|Renal(390;0.000147)|Breast(348;0.000162)|Colorectal(325;0.00058)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)	GBM - Glioblastoma multiforme(2;0.00182)	UCEC - Uterine corpus endometrioid carcinoma (279;0.00969)|Colorectal(212;4.48e-06)|COAD - Colon adenocarcinoma(227;0.000194)|BRCA - Breast invasive adenocarcinoma(304;0.000347)|Kidney(185;0.00087)|KIRC - Kidney renal clear cell carcinoma(229;0.0027)|STAD - Stomach adenocarcinoma(313;0.00802)|READ - Rectum adenocarcinoma(331;0.0678)		CCAGAAGATGACACTGAGACT	0.517		NaN											0	0	0	0.006999	0	34	52				
EPHA2	1969	broad.mit.edu	37	1	16456035	16456035	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:16456035G>T	uc001aya.1	-	16	2856	c.2719C>A	c.(2719-2721)CGC>AGC	p.R907S		NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	907	SAM.|Cytoplasmic (Potential).|Negatively regulates interaction with ARHGEF16.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	GACACCGTGCGGAAGGGCACC	0.478		NaN											1	0	1.66795e-42	0.00361	1.91836e-42	74	59				
WASF2	10163	broad.mit.edu	37	1	27745578	27745578	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:27745578C>T	uc001bof.1	-	3	358	c.142G>A	c.(142-144)GAG>AAG	p.E48K	WASF2_uc010ofl.1_Missense_Mutation_p.E48K	NM_006990	NP_008921	Q9Y6W5	WASF2_HUMAN	WAS protein family, member 2	48					actin cytoskeleton organization|G-protein signaling, coupled to cAMP nucleotide second messenger	actin cytoskeleton|lamellipodium	actin binding			skin(2)|ovary(1)	3		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0446)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.7e-08)|COAD - Colon adenocarcinoma(152;2e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00139)|KIRC - Kidney renal clear cell carcinoma(1967;0.00204)|STAD - Stomach adenocarcinoma(196;0.00325)|READ - Rectum adenocarcinoma(331;0.0481)		AAAATGTCCTCTGCATATTTA	0.443		NaN											0	0	0	0.008291	0	7	35				
STX12	23673	broad.mit.edu	37	1	28099877	28099877	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:28099877G>C	uc001bou.3	+	1	184	c.59G>C	c.(58-60)CGG>CCG	p.R20P		NM_177424	NP_803173	Q86Y82	STX12_HUMAN	syntaxin 12	20	Cytoplasmic (Potential).				cholesterol efflux|intracellular protein transport|protein stabilization|vesicle-mediated transport	Golgi apparatus|integral to membrane|membrane raft|phagocytic vesicle	SNAP receptor activity			breast(1)|central_nervous_system(1)	2		Colorectal(325;3.46e-05)|all_lung(284;9.43e-05)|Lung NSC(340;0.000185)|Renal(390;0.00121)|Breast(348;0.0021)|Ovarian(437;0.00503)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0434)|OV - Ovarian serous cystadenocarcinoma(117;3.96e-24)|Colorectal(126;3.46e-08)|COAD - Colon adenocarcinoma(152;1.83e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00258)|KIRC - Kidney renal clear cell carcinoma(1967;0.00302)|STAD - Stomach adenocarcinoma(196;0.00311)|READ - Rectum adenocarcinoma(331;0.0649)		CCCCAGCTCCGGGACTTCAGC	0.657		NaN											0	0	0	0.006999	0	37	39				
EPB41	2035	broad.mit.edu	37	1	29314319	29314319	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:29314319G>A	uc001brm.1	+	1	377	c.370G>A	c.(370-372)GAA>AAA	p.E124K	EPB41_uc001brg.1_5'UTR|EPB41_uc001brh.1_5'UTR|EPB41_uc001bri.1_Missense_Mutation_p.E124K|EPB41_uc001brj.1_5'UTR|EPB41_uc009vtk.1_Missense_Mutation_p.E124K|EPB41_uc001brk.2_Missense_Mutation_p.E124K|EPB41_uc001brl.1_Missense_Mutation_p.E124K|EPB41_uc009vtl.1_5'UTR|EPB41_uc009vtm.1_5'UTR	NM_203342	NP_976217	P11171	41_HUMAN	erythrocyte membrane protein band 4.1	124					blood circulation|cortical actin cytoskeleton organization|positive regulation of protein binding	extrinsic to membrane|Golgi apparatus|nucleus|plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	1-phosphatidylinositol binding|actin binding|spectrin binding|structural constituent of cytoskeleton			ovary(1)	1		Colorectal(325;3.46e-05)|Prostate(1639;0.000244)|Lung NSC(340;0.00328)|all_lung(284;0.00412)|Breast(348;0.00765)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.12e-07)|COAD - Colon adenocarcinoma(152;1.21e-05)|STAD - Stomach adenocarcinoma(196;0.00395)|KIRC - Kidney renal clear cell carcinoma(1967;0.0249)|BRCA - Breast invasive adenocarcinoma(304;0.0289)|READ - Rectum adenocarcinoma(331;0.0757)		CAGTCTTGATGAAGAGATCAT	0.423		NaN											0	0	0	0.003163	0	13	36				
CLSPN	63967	broad.mit.edu	37	1	36235553	36235553	+	Splice_Site	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:36235553C>T	uc001bzi.2	-	1	1	c.-79_splice	c.e1-1		CLSPN_uc009vux.2_Splice_Site	NM_022111	NP_071394	Q9HAW4	CLSPN_HUMAN	claspin						activation of protein kinase activity|cell cycle|cellular component disassembly involved in apoptosis|DNA repair|DNA replication|G2/M transition DNA damage checkpoint|mitotic cell cycle DNA replication checkpoint|peptidyl-serine phosphorylation	nucleoplasm	anaphase-promoting complex binding|DNA binding			breast(2)|ovary(2)|central_nervous_system(1)|lung(1)|skin(1)|kidney(1)	8		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				CCCGCCGTCTCCAGCCCAGCA	0.642		NaN											0	0	0	0.004482	0	9	29				
EIF2C1	26523	broad.mit.edu	37	1	36367599	36367599	+	Silent	SNP	C	C	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:36367599C>A	uc001bzl.2	+	10	1404	c.1191C>A	c.(1189-1191)ATC>ATA	p.I397I	EIF2C1_uc001bzk.2_Silent_p.I322I|EIF2C1_uc009vuy.2_Intron	NM_012199	NP_036331	Q9UL18	AGO1_HUMAN	eukaryotic translation initiation factor 2C, 1	397					negative regulation of translation involved in gene silencing by miRNA|nuclear-transcribed mRNA catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|polysome	protein binding|RNA binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AATTTGGGATCAAAGTGAAGG	0.542		NaN											1	0	1.22674e-20	0.00874	1.35988e-20	38	64				
KIAA0754	643314	broad.mit.edu	37	1	39876847	39876847	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:39876847C>G	uc009vvt.1	+	1	1672	c.910C>G	c.(910-912)CAT>GAT	p.H304D	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc010oiu.1_Intron	NM_015038	NP_055853	O94854	K0754_HUMAN	hypothetical protein LOC643314	168											0	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TCCAGAATTGCATGTTCTCAT	0.522		NaN									OREG0013393	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004482	0	6	15				
SLFNL1	200172	broad.mit.edu	37	1	41486281	41486281	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:41486281C>T	uc001cgm.1	-	2	272	c.52G>A	c.(52-54)GAG>AAG	p.E18K	SLFNL1_uc009vwf.1_Missense_Mutation_p.E18K|SLFNL1_uc001cgn.1_Missense_Mutation_p.E18K|SLFNL1_uc009vwg.1_Missense_Mutation_p.E18K	NM_144990	NP_659427	Q499Z3	SLNL1_HUMAN	schlafen-like 1	18							ATP binding			skin(1)	1	Ovarian(52;0.00769)|all_hematologic(146;0.0977)|Breast(333;0.1)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0393)				CCCCAGGACTCCATGAAGGGC	0.607		NaN											0	0	0	0.00361	0	67	62				
TMEM53	79639	broad.mit.edu	37	1	45120323	45120323	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:45120323C>T	uc001cmc.2	-	3	778	c.742G>A	c.(742-744)GTG>ATG	p.V248M	TMEM53_uc001cmb.1_Intron|TMEM53_uc001cmd.2_Missense_Mutation_p.V175M|TMEM53_uc009vxh.1_Missense_Mutation_p.V131M|TMEM53_uc010ola.1_Missense_Mutation_p.V131M	NM_024587	NP_078863	Q6P2H8	TMM53_HUMAN	transmembrane protein 53	248						integral to membrane				ovary(2)	2	Acute lymphoblastic leukemia(166;0.155)					GCAGATGACACGAAATCCACA	0.592		NaN											0	0	0	0.00361	0	118	134				
NASP	4678	broad.mit.edu	37	1	46073334	46073334	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:46073334C>A	uc001coi.1	+	6	853	c.751C>A	c.(751-753)CAA>AAA	p.Q251K	NASP_uc010olq.1_Missense_Mutation_p.Q214K|NASP_uc001coh.1_Missense_Mutation_p.Q253K|NASP_uc001coj.1_Intron|NASP_uc010olr.1_Missense_Mutation_p.Q187K|NASP_uc001cok.1_Missense_Mutation_p.Q134K	NM_002482	NP_002473	P49321	NASP_HUMAN	nuclear autoantigenic sperm protein isoform 2	251	Glu-rich (acidic).				blastocyst development|cell cycle|cell proliferation|DNA replication|histone exchange|protein transport	cytoplasm|nucleus	Hsp90 protein binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.211)					AACTGATGTCCAAGAAGAGTG	0.478		NaN											1	0	2.56e-06	0.009096	2.64e-06	3	16				
MAST2	23139	broad.mit.edu	37	1	46497147	46497147	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:46497147C>A	uc001cov.2	+	24	3360	c.3077C>A	c.(3076-3078)GCC>GAC	p.A1026D	MAST2_uc001cow.2_Missense_Mutation_p.A1026D|MAST2_uc001cpa.2_RNA	NM_015112	NP_055927	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase	1026					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			ovary(5)|lung(3)|stomach(2)|breast(1)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					GTGCGTAGGGCCCGCCACCGG	0.627		NaN											1	0	1.57351e-24	0.003755	1.75791e-24	32	96				
MAST2	23139	broad.mit.edu	37	1	46501315	46501315	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:46501315G>C	uc001cov.2	+	29	5257	c.4974G>C	c.(4972-4974)TGG>TGC	p.W1658C	MAST2_uc001cow.2_Missense_Mutation_p.W1657C|MAST2_uc001cpa.2_RNA	NM_015112	NP_055927	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase	1658					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			ovary(5)|lung(3)|stomach(2)|breast(1)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					TGTGGTCCTGGAAATCCCTTA	0.572		NaN											0	0	0	0.002299	0	18	49				
UQCRH	7388	broad.mit.edu	37	1	46769446	46769446	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:46769446T>C	uc001cpp.2	+	1	67	c.8T>C	c.(7-9)CTG>CCG	p.L3P	LRRC41_uc001cpn.2_5'Flank|LRRC41_uc010omb.1_5'Flank|LRRC41_uc001cpo.1_5'Flank|UQCRH_uc001cpq.2_RNA	NM_006004	NP_005995	P07919	QCR6_HUMAN	ubiquinol-cytochrome c reductase hinge protein	3					aerobic respiration|mitochondrial electron transport, ubiquinol to cytochrome c		ubiquinol-cytochrome-c reductase activity				0	Acute lymphoblastic leukemia(166;0.155)					GACATGGGACTGGAGGACGAG	0.552		NaN											0	0	0	0.005443	0	20	60				
ATPAF1	64756	broad.mit.edu	37	1	47110887	47110887	+	Silent	SNP	A	A	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:47110887A>G	uc001cqh.2	-	7	735	c.630T>C	c.(628-630)TTT>TTC	p.F210F	ATPAF1_uc001cqg.2_Intron|ATPAF1_uc009vyk.2_Silent_p.F59F|ATPAF1_uc010omg.1_Silent_p.F122F|ATPAF1_uc001cqi.2_Intron	NM_022745	NP_073582	Q5TC12	ATPF1_HUMAN	ATP synthase mitochondrial F1 complex assembly	210					protein complex assembly	mitochondrion	protein binding				0	Acute lymphoblastic leukemia(166;0.155)					ATTGTCCTACAAAAAACTCAT	0.398		NaN											0	0	0	0.006122	0	15	48				
RAB3B	5865	broad.mit.edu	37	1	52442691	52442691	+	Silent	SNP	A	A	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:52442691A>C	uc001cth.2	-	2	224	c.99T>G	c.(97-99)GTT>GTG	p.V33V		NM_002867	NP_002858	P20337	RAB3B_HUMAN	RAB3B, member RAS oncogene family	33	GTP.				protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			ovary(1)	1						AGGTCTTGCCAACACTGCTGT	0.483		NaN											0	0	0	0.00361	0	67	39				
CC2D1B	200014	broad.mit.edu	37	1	52821951	52821951	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:52821951C>G	uc001ctq.1	-	18	2117	c.1979G>C	c.(1978-1980)CGC>CCC	p.R660P	CC2D1B_uc001ctr.2_Missense_Mutation_p.R200P|CC2D1B_uc001cts.2_Missense_Mutation_p.R345P	NM_032449	NP_115825	Q5T0F9	C2D1B_HUMAN	coiled-coil and C2 domain containing 1B	660										ovary(2)	2						CTGTTTCTTGCGGTCCTGAGC	0.567		NaN											0	0	0	0.00874	0	39	126				
PODN	127435	broad.mit.edu	37	1	53542872	53542872	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:53542872C>G	uc001cuv.2	+	6	743	c.736C>G	c.(736-738)CTG>GTG	p.L246V	PODN_uc001cuw.2_Missense_Mutation_p.L227V|PODN_uc010onr.1_Missense_Mutation_p.L227V|PODN_uc010ons.1_Intron	NM_153703	NP_714914	Q7Z5L7	PODN_HUMAN	podocan	198	LRR 5.				negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding			ovary(1)|pancreas(1)	2						GTCTGTGTACCTGCACAACAA	0.627		NaN											0	0	0	0.00361	0	66	204				
EFCAB7	84455	broad.mit.edu	37	1	64021038	64021038	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:64021038T>C	uc001dbf.2	+	9	1360	c.1066T>C	c.(1066-1068)TGG>CGG	p.W356R		NM_032437	NP_115813	A8K855	EFCB7_HUMAN	EF-hand calcium binding domain 7	356							calcium ion binding				0						GGTGTTTGGATGGACTGGTGA	0.343		NaN											0	0	0	0.00361	0	34	22				
TNNI3K	51086	broad.mit.edu	37	1	74835181	74835181	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:74835181G>A	uc001dgf.1	+	16	1630	c.1579G>A	c.(1579-1581)GCT>ACT	p.A527T	TNNI3K_uc001dgc.1_Missense_Mutation_p.A628T|TNNI3K_uc001dgd.2_Missense_Mutation_p.A628T|TNNI3K_uc001dge.1_Missense_Mutation_p.A628T	NM_015978	NP_057062	Q59H18	TNI3K_HUMAN	TNNI3 interacting kinase isoform b	527	Protein kinase.					cytoplasm|nucleus	ATP binding|metal ion binding|protein C-terminus binding|protein serine/threonine kinase activity|troponin I binding			large_intestine(4)|lung(3)|ovary(2)|upper_aerodigestive_tract(1)	10						GTTTGTGGGTGCTTGCTTGAA	0.478		NaN											0	0	0	0.002096	0	26	61				
ZZZ3	26009	broad.mit.edu	37	1	78050334	78050334	+	Silent	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:78050334C>T	uc001dhq.2	-	6	1988	c.1512G>A	c.(1510-1512)CAG>CAA	p.Q504Q	ZZZ3_uc001dhr.2_Silent_p.Q10Q|ZZZ3_uc009wbz.1_3'UTR|ZZZ3_uc001dhp.2_Silent_p.Q504Q	NM_015534	NP_056349	Q8IYH5	ZZZ3_HUMAN	zinc finger, ZZ-type containing 3	504					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)|large_intestine(1)	5						GTAATAGTCTCTGATAACTAC	0.373		NaN											0	0	0	0.00308	0	7	17				
COL24A1	255631	broad.mit.edu	37	1	86590911	86590911	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:86590911G>A	uc001dlj.2	-	3	1150	c.1108C>T	c.(1108-1110)CTC>TTC	p.L370F	COL24A1_uc010osd.1_5'UTR|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA|COL24A1_uc009wcq.2_Missense_Mutation_p.L370F	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	370					cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		ATGTTTAGGAGAGAGCTAAAT	0.378		NaN											0	0	0	0.009535	0	21	19				
SLC30A7	148867	broad.mit.edu	37	1	101362198	101362198	+	Silent	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:101362198G>A	uc001dtn.2	+	2	340	c.153G>A	c.(151-153)GTG>GTA	p.V51V	EXTL2_uc001dtk.1_5'Flank|EXTL2_uc001dtl.1_5'Flank|EXTL2_uc010ouk.1_5'Flank|EXTL2_uc001dtm.1_5'Flank|SLC30A7_uc001dto.2_Silent_p.V51V	NM_001144884	NP_001138356	Q8NEW0	ZNT7_HUMAN	zinc transporter like 2	51	Helical; (Potential).				zinc ion transport	Golgi apparatus|integral to membrane	cation transmembrane transporter activity|protein binding				0		all_epithelial(167;0.000445)|all_lung(203;0.00645)|Lung NSC(277;0.0119)		Epithelial(280;0.0437)|all cancers(265;0.0498)|COAD - Colon adenocarcinoma(174;0.162)|Colorectal(144;0.19)|Lung(183;0.201)		TCGCTTTTGTGGAACTACTCT	0.502		NaN											0	0	0	0.00308	0	7	19				
KIAA1324	57535	broad.mit.edu	37	1	109731742	109731742	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:109731742G>A	uc001dwq.2	+	11	1410	c.1274G>A	c.(1273-1275)TGG>TAG	p.W425*	KIAA1324_uc009wex.1_Nonsense_Mutation_p.W375*|KIAA1324_uc009wey.2_Nonsense_Mutation_p.W338*|KIAA1324_uc010ovg.1_Nonsense_Mutation_p.W323*|KIAA1324_uc001dwr.2_Nonsense_Mutation_p.W75*	NM_020775	NP_065826	Q6UXG2	K1324_HUMAN	hypothetical protein LOC57535 precursor	425	Extracellular (Potential).				macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	5		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		GAATACAAATGGTGGAACACG	0.527		NaN											0	0	0	0.003271	0	30	30				
PTPN22	26191	broad.mit.edu	37	1	114372323	114372323	+	Missense_Mutation	SNP	T	T	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:114372323T>G	uc001eds.2	-	18	2271	c.2141A>C	c.(2140-2142)CAG>CCG	p.Q714P	PTPN22_uc009wgq.2_Missense_Mutation_p.Q659P|PTPN22_uc010owo.1_Missense_Mutation_p.Q470P|PTPN22_uc001edt.2_Intron|PTPN22_uc009wgr.2_Missense_Mutation_p.Q714P|PTPN22_uc009wgs.2_Missense_Mutation_p.Q587P	NM_015967	NP_057051	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type	714					negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			kidney(2)|lung(1)|skin(1)	4	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		AGATTGGGCCTGCATACCTTA	0.338		NaN											0	0	0	0.004672	0	3	15				
AP4B1	10717	broad.mit.edu	37	1	114442966	114442966	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:114442966T>C	uc001eeb.2	-	5	817	c.674A>G	c.(673-675)TAC>TGC	p.Y225C	uc001edv.1_RNA|AP4B1_uc001eec.2_Missense_Mutation_p.Y57C|AP4B1_uc001eed.2_Missense_Mutation_p.Y225C|AP4B1_uc010owp.1_Missense_Mutation_p.Y126C|AP4B1_uc001eea.1_Missense_Mutation_p.Y19C|AP4B1_uc010owq.1_Missense_Mutation_p.Y132C	NM_006594	NP_006585	Q9Y6B7	AP4B1_HUMAN	adaptor-related protein complex 4, beta 1	225					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|soluble fraction|trans-Golgi network	protein binding|protein transporter activity			ovary(3)|central_nervous_system(1)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.1e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCGGGGTTGGTAGCGTAGCAG	0.423		NaN											0	0	0	0.00632	0	21	29				
HIPK1	204851	broad.mit.edu	37	1	114512680	114512680	+	Silent	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:114512680G>A	uc001eem.2	+	14	3035	c.2874G>A	c.(2872-2874)CTG>CTA	p.L958L	HIPK1_uc001eel.2_Silent_p.L958L|HIPK1_uc001een.2_Silent_p.L958L|HIPK1_uc001eeo.2_Silent_p.L584L|HIPK1_uc001eep.2_Silent_p.L564L|HIPK1_uc001eeq.2_Silent_p.L250L	NM_198268	NP_938009	Q86Z02	HIPK1_HUMAN	homeodomain-interacting protein kinase 1 isoform	958	Required for localization to nuclear speckles (By similarity).|Interaction with TP53.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(4)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTGATACCCTGAGTGCTCTCC	0.507		NaN											0	0	0	0.00361	0	49	103				
ZNF697	90874	broad.mit.edu	37	1	120166097	120166097	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:120166097A>T	uc001ehy.1	-	3	983	c.869T>A	c.(868-870)CTG>CAG	p.L290Q		NM_001080470	NP_001073939	Q5TEC3	ZN697_HUMAN	zinc finger protein 697	290	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_neural(166;0.219)	all_lung(203;3.66e-05)|Lung NSC(69;0.000202)|all_epithelial(167;0.0266)		Lung(183;0.011)|LUSC - Lung squamous cell carcinoma(189;0.0577)		GTCGGCGCACAGGTTGGGCCG	0.687		NaN											0	0	0	0.004656	0	21	17				
NOTCH2	4853	broad.mit.edu	37	1	120529583	120529583	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:120529583C>T	uc001eik.2	-	5	1130	c.874G>A	c.(874-876)GGA>AGA	p.G292R	NOTCH2_uc001eil.2_Missense_Mutation_p.G292R|NOTCH2_uc001eim.3_Missense_Mutation_p.G209R	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	292	EGF-like 7; calcium-binding (Potential).|Extracellular (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTGTACATACCTGTCCATTGT	0.458		NaN	N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				0	0	0	0.00361	0	37	44				
RPRD2	23248	broad.mit.edu	37	1	150444196	150444196	+	Silent	SNP	G	G	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:150444196G>T	uc009wlr.2	+	11	2973	c.2772G>T	c.(2770-2772)GGG>GGT	p.G924G	RPRD2_uc010pcc.1_Silent_p.G898G|RPRD2_uc001eup.3_Silent_p.G898G	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Regulation of nuclear pre-mRNA domain containing	924	Ser-rich.						protein binding			ovary(1)	1						ATGAACCTGGGTCTGACCGGT	0.507		NaN											1	0	1.28101e-76	0.00361	1.49742e-76	127	119				
FLG2	388698	broad.mit.edu	37	1	152328005	152328005	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:152328005C>T	uc001ezw.3	-	3	2330	c.2257G>A	c.(2257-2259)GGA>AGA	p.G753R	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	753	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GAGGATTGTCCTGAGCCAGAC	0.512		NaN											0	0	0	0.00361	0	148	236				
GON4L	54856	broad.mit.edu	37	1	155796703	155796703	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:155796703G>C	uc001flz.2	-	3	719	c.622C>G	c.(622-624)CAA>GAA	p.Q208E	GON4L_uc001fly.1_Missense_Mutation_p.Q208E|GON4L_uc009wrh.1_Missense_Mutation_p.Q208E|GON4L_uc001fma.1_Missense_Mutation_p.Q208E|GON4L_uc001fmc.2_Missense_Mutation_p.Q208E|GON4L_uc001fmd.3_Missense_Mutation_p.Q208E|GON4L_uc009wri.2_5'UTR|GON4L_uc001fme.2_Missense_Mutation_p.Q36E	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	208					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					GGCTTTTCTTGAGGAGAGGCA	0.468		NaN											0	0	0	0.006122	0	14	49				
OR10Z1	128368	broad.mit.edu	37	1	158576875	158576875	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:158576875T>C	uc010pio.1	+	1	647	c.647T>C	c.(646-648)ATC>ACC	p.I216T		NM_001004478	NP_001004478	Q8NGY1	O10Z1_HUMAN	olfactory receptor, family 10, subfamily Z,	216	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)|skin(1)	2	all_hematologic(112;0.0378)					TTCATCACCATCTCCTACGCC	0.532		NaN											0	0	0	0.009535	0	30	34				
ADCY10	55811	broad.mit.edu	37	1	167814903	167814903	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:167814903C>T	uc001ger.2	-	21	3203	c.2905G>A	c.(2905-2907)GGC>AGC	p.G969S	ADCY10_uc009wvk.2_Missense_Mutation_p.G877S|ADCY10_uc010plj.1_Missense_Mutation_p.G816S|ADCY10_uc009wvl.2_Missense_Mutation_p.G968S	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	969					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						AAGTCCCTGCCTCGGCAGTGG	0.463		NaN											0	0	0	0.007413	0	15	36				
RFWD2	64326	broad.mit.edu	37	1	176133011	176133011	+	Silent	SNP	A	A	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:176133011A>G	uc001gku.1	-	4	838	c.582T>C	c.(580-582)CTT>CTC	p.L194L	RFWD2_uc001gkv.1_Silent_p.L194L|RFWD2_uc001gkw.1_Intron|RFWD2_uc009wwv.2_5'Flank|RFWD2_uc001gkt.1_Silent_p.L53L	NM_022457	NP_071902	Q8NHY2	RFWD2_HUMAN	ring finger and WD repeat domain 2 isoform a	194					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0						GCTTCTGTTTAAGAATGAGTT	0.289		NaN											0	0	0	0.004672	0	2	7				
PRG4	10216	broad.mit.edu	37	1	186280667	186280667	+	Silent	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:186280667G>A	uc001gru.3	+	10	3783	c.3732G>A	c.(3730-3732)GTG>GTA	p.V1244V	PRG4_uc001grt.3_Silent_p.V1203V|PRG4_uc009wyl.2_Silent_p.V1151V|PRG4_uc009wym.2_Silent_p.V1110V|PRG4_uc010poo.1_RNA	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	1244					cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						GACAAATAGTGGCAGCGCTTT	0.363		NaN											0	0	0	0.00308	0	7	16				
CRB1	23418	broad.mit.edu	37	1	197390711	197390711	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:197390711G>C	uc001gtz.2	+	6	1888	c.1753G>C	c.(1753-1755)GAC>CAC	p.D585H	CRB1_uc010poz.1_Missense_Mutation_p.D516H|CRB1_uc010ppa.1_Intron|CRB1_uc009wza.2_Missense_Mutation_p.D473H|CRB1_uc010ppb.1_Missense_Mutation_p.D585H|CRB1_uc010ppc.1_Intron|CRB1_uc010ppd.1_Missense_Mutation_p.D66H|CRB1_uc001gub.1_Missense_Mutation_p.D234H	NM_201253	NP_957705	P82279	CRUM1_HUMAN	crumbs homolog 1 precursor	585	Extracellular (Potential).|Laminin G-like 1.				cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			ovary(5)|skin(3)|large_intestine(1)	9						CTTAATCGACGACTCCTGTAA	0.453		NaN											0	0	0	0.008871	0	20	24				
SYT2	127833	broad.mit.edu	37	1	202569525	202569525	+	Silent	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:202569525C>T	uc001gye.2	-	7	1072	c.879G>A	c.(877-879)GAG>GAA	p.E293E	SYT2_uc010pqb.1_Silent_p.E293E|SYT2_uc009xaf.2_Silent_p.E123E	NM_001136504	NP_001129976	Q8N9I0	SYT2_HUMAN	synaptotagmin II	293	Phospholipid binding (By similarity).|C2 2.|Cytoplasmic (Potential).				neurotransmitter secretion	cell junction|chromaffin granule membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	protein binding|transporter activity			ovary(2)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.169)		Botulinum Toxin Type B(DB00042)	GGTTCTTAGCCTCCAGGATGC	0.617		NaN									OREG0014101	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00361	0	56	55				
CYB5R1	51706	broad.mit.edu	37	1	202935955	202935955	+	Silent	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:202935955C>T	uc001gyt.2	-	2	158	c.87G>A	c.(85-87)TTG>TTA	p.L29L	CYB5R1_uc010pqe.1_RNA	NM_016243	NP_057327	Q9UHQ9	NB5R1_HUMAN	cytochrome b5 reductase 1	29					sterol biosynthetic process	integral to membrane	cytochrome-b5 reductase activity			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(75;0.141)			ACCTCCGAACCAAGTAGGAGC	0.642		NaN											0	0	0	0.004482	0	9	37				
REN	5972	broad.mit.edu	37	1	204124152	204124152	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:204124152C>T	uc001haq.2	-	10	1257	c.1213G>A	c.(1213-1215)GCC>ACC	p.A405T	ETNK2_uc001hao.3_5'Flank|ETNK2_uc001han.3_5'Flank|ETNK2_uc010pqs.1_5'Flank|ETNK2_uc010pqt.1_5'Flank	NM_000537	NP_000528	P00797	RENI_HUMAN	renin preproprotein	405					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			skin(3)|central_nervous_system(1)	4	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	CCTCAGCGGGCCAAGGCGAAG	0.647		NaN											0	0	0	0.00333	0	18	66				
LRRN2	10446	broad.mit.edu	37	1	204587882	204587882	+	Silent	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:204587882G>A	uc001hbe.1	-	3	1627	c.1239C>T	c.(1237-1239)TTC>TTT	p.F413F	MDM4_uc001hbd.1_Intron|LRRN2_uc001hbf.1_Silent_p.F413F|LRRN2_uc009xbf.1_Silent_p.F413F|MDM4_uc001hbc.2_Intron	NM_006338	NP_006329	O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2 precursor	413	Extracellular (Potential).|LRRCT.				cell adhesion	integral to membrane	receptor activity			central_nervous_system(2)	2	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			TCATCTCCCGGAAGGGCACCT	0.662		NaN											0	0	0	0.010504	0	20	67				
CR1	1378	broad.mit.edu	37	1	207679368	207679369	+	Missense_Mutation	DNP	CC	CC	GA			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:207679368_207679369CC>GA	uc001hfy.2	+	2	381_382	c.241_242CC>GA	c.(241-243)CCG>GAG	p.P81E	CR1_uc009xcl.1_Missense_Mutation_p.P81E|CR1_uc001hfx.2_Missense_Mutation_p.P81E|CR1_uc010psg.1_Missense_Mutation_p.P81E|CR1_uc009xcj.1_Missense_Mutation_p.P81E|CR1_uc009xck.1_Missense_Mutation_p.P81E	NM_000573	NP_000564	P17927	CR1_HUMAN	complement receptor 1 isoform F precursor	81	Sushi 1.|Extracellular (Potential).				complement activation, classical pathway|innate immune response	integral to plasma membrane	complement receptor activity			ovary(3)	3						TTCCGGAAGACCGTTTTCTATC	0.47		NaN											0	0	0	0.004672	0	8	44				
CD46	4179	broad.mit.edu	37	1	207930506	207930506	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:207930506G>A	uc001hgc.2	+	2	401	c.245G>A	c.(244-246)CGG>CAG	p.R82Q	CD46_uc001hgd.2_Missense_Mutation_p.R82Q|CD46_uc001hge.2_Missense_Mutation_p.R82Q|CD46_uc001hgf.2_Missense_Mutation_p.R82Q|CD46_uc001hgg.2_Missense_Mutation_p.R82Q|CD46_uc001hgh.2_Missense_Mutation_p.R82Q|CD46_uc001hgi.2_Missense_Mutation_p.R82Q|CD46_uc001hgj.2_Missense_Mutation_p.R82Q|CD46_uc001hgk.2_Missense_Mutation_p.R82Q|CD46_uc001hgl.2_Missense_Mutation_p.R82Q|CD46_uc001hgm.2_Missense_Mutation_p.R82Q|CD46_uc001hgn.2_Missense_Mutation_p.R82Q|CD46_uc001hgo.2_Missense_Mutation_p.R82Q|CD46_uc001hgp.2_Missense_Mutation_p.R82Q	NM_002389	NP_002380	P15529	MCP_HUMAN	CD46 antigen, complement regulatory protein	82	Extracellular (Potential).|Sushi 1.				complement activation, classical pathway|innate immune response|interspecies interaction between organisms|single fertilization	inner acrosomal membrane|integral to plasma membrane	protein binding|receptor activity			large_intestine(2)|lung(1)|central_nervous_system(1)	4						ATTTGTGATCGGAATCATACA	0.368		NaN											0	0	0	0.006999	0	31	29				
FLVCR1	28982	broad.mit.edu	37	1	213032442	213032442	+	Silent	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:213032442C>T	uc001hjt.2	+	1	846	c.648C>T	c.(646-648)TTC>TTT	p.F216F	LQK1_uc001hjr.3_5'Flank|LQK1_uc001hjs.3_5'Flank	NM_014053	NP_054772	Q9Y5Y0	FLVC1_HUMAN	feline leukemia virus subgroup C cellular	216	Helical; (Potential).				cell death|cellular iron ion homeostasis|heme export|transmembrane transport	integral to plasma membrane	heme transporter activity|protein binding|receptor activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.00733)|all cancers(67;0.013)|GBM - Glioblastoma multiforme(131;0.0845)|Epithelial(68;0.11)		CCCAGGTGTTCATCCTGGGCT	0.607		NaN											0	0	0	0.00361	0	46	67				
CDC42BPA	8476	broad.mit.edu	37	1	227259910	227259910	+	Silent	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:227259910C>T	uc001hqr.2	-	20	3769	c.2826G>A	c.(2824-2826)AAG>AAA	p.K942K	CDC42BPA_uc001hqq.2_Silent_p.K206K|CDC42BPA_uc001hqs.2_Silent_p.K861K|CDC42BPA_uc009xes.2_Silent_p.K942K|CDC42BPA_uc010pvs.1_Silent_p.K942K|CDC42BPA_uc001hqp.2_Silent_p.K98K|CDC42BPA_uc001hqu.1_Silent_p.K98K	NM_003607	NP_003598	Q5VT25	MRCKA_HUMAN	CDC42-binding protein kinase alpha isoform B	942	Potential.				actin cytoskeleton reorganization|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm	ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			lung(6)|breast(2)|stomach(1)|ovary(1)|pancreas(1)	11		all_cancers(173;0.156)|Prostate(94;0.0792)				CTCCCATACCCTTTTCAGATC	0.348		NaN											0	0	0	0.000978	0	8	18				
KIAA1804	84451	broad.mit.edu	37	1	233512183	233512183	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:233512183C>A	uc001hvt.3	+	8	2095	c.1834C>A	c.(1834-1836)CCT>ACT	p.P612T	KIAA1804_uc001hvu.3_Missense_Mutation_p.P58T	NM_032435	NP_115811	Q5TCX8	M3KL4_HUMAN	mixed lineage kinase 4	612					activation of JUN kinase activity|protein autophosphorylation		ATP binding|MAP kinase kinase kinase activity|protein homodimerization activity			lung(5)|central_nervous_system(2)|skin(1)	8		all_cancers(173;0.000405)|all_epithelial(177;0.0345)|Prostate(94;0.122)				TAGGATAAGACCTCTCTCCGA	0.378		NaN											1	0	0.000602214	0.000602	0.000615119	3	17				
FH	2271	broad.mit.edu	37	1	241680601	241680601	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:241680601A>T	uc001hyx.2	-	2	180	c.148T>A	c.(148-150)TTC>ATC	p.F50I		NM_000143	NP_000134	P07954	FUMH_HUMAN	fumarate hydratase precursor	50					fumarate metabolic process|tricarboxylic acid cycle	cell junction|mitochondrial matrix|tricarboxylic acid cycle enzyme complex	fumarate hydratase activity			lung(3)|ovary(1)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;2.37e-314)|all_epithelial(177;5.17e-286)|Breast(1374;1.06e-10)|Acute lymphoblastic leukemia(190;4.93e-10)|all_neural(198;0.00118)	OV - Ovarian serous cystadenocarcinoma(106;0.0214)	Colorectal(1306;2.33e-53)|COAD - Colon adenocarcinoma(196;1.05e-44)|KIRC - Kidney renal clear cell carcinoma(1967;0.000109)		TCTATCCGGAAGGAATTTTGG	0.383		NaN	Mis|N|F			lieomyomatosis|renal			Hereditary_Leiomyomatosis_and_Renal_Cell_Cancer				0	0	0	0.004672	0	3	16				
PFKP	5214	broad.mit.edu	37	10	3162099	3162099	+	Silent	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr10:3162099C>T	uc001igp.2	+	16	1582	c.1546C>T	c.(1546-1548)CTG>TTG	p.L516L	PFKP_uc001igq.2_Silent_p.L508L|PFKP_uc009xhr.2_Silent_p.L478L|PFKP_uc009xhs.1_Silent_p.L300L|PFKP_uc009xht.2_Silent_p.L254L|PFKP_uc009xhu.2_Silent_p.L22L	NM_002627	NP_002618	Q01813	K6PP_HUMAN	phosphofructokinase, platelet	516					glycolysis	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|metal ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)|lung(1)	3				GBM - Glioblastoma multiforme(1;0.000975)|all cancers(11;0.00351)|Epithelial(11;0.142)		CCTGGGACTCCTGGAGCTGTC	0.632		NaN									OREG0019976	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00361	0	72	175				
ITIH5	80760	broad.mit.edu	37	10	7621948	7621948	+	Silent	SNP	C	C	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr10:7621948C>A	uc001ijq.2	-	9	1267	c.1188G>T	c.(1186-1188)CGG>CGT	p.R396R	ITIH5_uc001ijp.2_Silent_p.R182R|ITIH5_uc001ijr.1_Silent_p.R396R	NM_030569	NP_085046	Q86UX2	ITIH5_HUMAN	inter-alpha trypsin inhibitor heavy chain	396	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)	4						GGGACACGCTCCGGTCTCCAA	0.632		NaN											1	0	8.20599e-20	0.002852	9.07311e-20	44	38				
PRPF18	8559	broad.mit.edu	37	10	13655788	13655788	+	Silent	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr10:13655788T>C	uc001imp.2	+	7	775	c.627T>C	c.(625-627)TAT>TAC	p.Y209Y	PRPF18_uc001imq.2_Intron	NM_003675	NP_003666	Q99633	PRP18_HUMAN	PRP18 pre-mRNA processing factor 18 homolog	209					mRNA processing|RNA splicing	nuclear speck|spliceosomal complex				central_nervous_system(1)	1						GAGAAGATTATGTGAAACGCA	0.453		NaN											0	0	0	0.000978	0	10	41				
ZNF485	220992	broad.mit.edu	37	10	44112556	44112556	+	Silent	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr10:44112556G>A	uc010qfc.1	+	5	1259	c.1065G>A	c.(1063-1065)CAG>CAA	p.Q355Q	ZNF485_uc010qfd.1_Silent_p.Q264Q	NM_145312	NP_660355	Q8NCK3	ZN485_HUMAN	zinc finger protein 485	355	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						AACCGTATCAGTGTCGTGACT	0.428		NaN											0	0	0	0.008871	0	17	69				
SYT15	83849	broad.mit.edu	37	10	46969378	46969378	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr10:46969378A>G	uc001jea.2	-	2	236	c.83T>C	c.(82-84)CTG>CCG	p.L28P	SYT15_uc001jdz.2_Missense_Mutation_p.L28P|SYT15_uc001jeb.2_Intron|SYT15_uc010qfp.1_5'Flank	NM_031912	NP_114118	Q9BQS2	SYT15_HUMAN	synaptotagmin XV isoform a	28	Helical; Signal-anchor for type III membrane protein; (Potential).					integral to membrane|plasma membrane					0						CCTTCTCCACAGACAGCAGCT	0.652		NaN											0	0	0	0.00361	0	55	162				
NRBF2	29982	broad.mit.edu	37	10	64911926	64911926	+	Silent	SNP	C	C	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr10:64911926C>G	uc001jmj.3	+	3	356	c.132C>G	c.(130-132)GCC>GCG	p.A44A	NRBF2_uc010qip.1_Silent_p.A34A	NM_030759	NP_110386	Q96F24	NRBF2_HUMAN	nuclear receptor binding factor 2	44					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	cytoplasm|nucleoplasm	protein binding				0	Prostate(12;0.0119)|all_hematologic(501;0.191)					TTTCTGAAGCCATGAAGCTGA	0.353		NaN											0	0	0	0.008291	0	8	43				
CDH23	64072	broad.mit.edu	37	10	73574769	73574769	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr10:73574769C>T	uc001jrx.3	+	68	10176	c.9799C>T	c.(9799-9801)CGC>TGC	p.R3267C	CDH23_uc001jsg.3_Missense_Mutation_p.R1027C|CDH23_uc001jsh.3_Missense_Mutation_p.R992C|CDH23_uc001jsi.3_Missense_Mutation_p.R992C|CDH23_uc001jsj.3_Missense_Mutation_p.R164C|CDH23_uc010qjr.1_Missense_Mutation_p.R129C	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	3267	Cytoplasmic (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						GGGTAGCCTGCGCTTCCGCCA	0.667		NaN											0	0	0	0.006122	0	15	86				
CAMK2G	818	broad.mit.edu	37	10	75634270	75634270	+	Translation_Start_Site	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr10:75634270C>T	uc001jvv.1	-	1	74	c.-50G>A	c.(-52--48)CTGTG>CTATG		CAMK2G_uc001jvm.1_Translation_Start_Site|CAMK2G_uc001jvo.1_Translation_Start_Site|CAMK2G_uc001jvq.1_Translation_Start_Site|CAMK2G_uc001jvr.1_Translation_Start_Site|CAMK2G_uc001jvp.1_Translation_Start_Site|CAMK2G_uc001jvs.1_Translation_Start_Site|CAMK2G_uc001jvt.1_RNA|CAMK2G_uc001jvu.1_Translation_Start_Site|CAMK2G_uc010qkv.1_Translation_Start_Site	NM_172171	NP_751911	Q13555	KCC2G_HUMAN	calcium/calmodulin-dependent protein kinase II						insulin secretion|interferon-gamma-mediated signaling pathway|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calcium-dependent protein serine/threonine phosphatase activity|calmodulin binding|calmodulin-dependent protein kinase activity			lung(1)|stomach(1)	2	Prostate(51;0.0112)					CGTCGGTGCACAGTCACCGCC	0.721		NaN											0	0	0	0.000978	0	8	27				
PLCE1	51196	broad.mit.edu	37	10	96025625	96025625	+	Silent	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr10:96025625C>T	uc001kjk.2	+	16	4825	c.4191C>T	c.(4189-4191)CCC>CCT	p.P1397P	PLCE1_uc010qnx.1_Silent_p.P1381P|PLCE1_uc001kjm.2_Silent_p.P1089P	NM_016341	NP_057425	Q9P212	PLCE1_HUMAN	phospholipase C, epsilon 1 isoform 1	1397	PI-PLC X-box.				activation of MAPK activity|activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cell proliferation|cytoskeleton organization|diacylglycerol biosynthetic process|elevation of cytosolic calcium ion concentration|epidermal growth factor receptor signaling pathway|glomerulus development|heart development|lipid catabolic process|Ras protein signal transduction|regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|regulation of Ras protein signal transduction|regulation of smooth muscle contraction	cytosol|Golgi membrane|membrane fraction|plasma membrane	calcium ion binding|guanyl-nucleotide exchange factor activity|phosphatidylinositol phospholipase C activity|Ras GTPase binding|receptor signaling protein activity			ovary(2)|skin(1)	3		Colorectal(252;0.0458)				TGCAGCTACCCCTCTCATACT	0.413		NaN											0	0	0	0.007413	0	18	4				
PDZD8	118987	broad.mit.edu	37	10	119044045	119044045	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr10:119044045A>T	uc001lde.1	-	5	2398	c.2199T>A	c.(2197-2199)AGT>AGA	p.S733R		NM_173791	NP_776152	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	733					intracellular signal transduction		metal ion binding				0		Colorectal(252;0.19)		all cancers(201;0.0121)		CAAGTTTTAAACTAACATGCC	0.438		NaN											0	0	0	0.00245	0	12	4				
MKI67	4288	broad.mit.edu	37	10	129903242	129903242	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr10:129903242G>A	uc001lke.2	-	13	7057	c.6862C>T	c.(6862-6864)CAG>TAG	p.Q2288*	MKI67_uc001lkf.2_Nonsense_Mutation_p.Q1928*|MKI67_uc009yav.1_Nonsense_Mutation_p.Q1863*|MKI67_uc009yaw.1_Nonsense_Mutation_p.Q1438*	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	2288	16 X 122 AA approximate repeats.|11.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TCCAATTTCTGCACTGGAGTT	0.483		NaN											0	0	0	0.00361	0	45	20				
GPR123	84435	broad.mit.edu	37	10	134912182	134912182	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr10:134912182T>A	uc001llx.3	+	4	606	c.170T>A	c.(169-171)CTG>CAG	p.L57Q	GPR123_uc001llw.2_Missense_Mutation_p.L777Q	NM_001083909	NP_001077378	Q86SQ6	GP123_HUMAN	G protein-coupled receptor 123	57	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0		all_cancers(35;1.8e-10)|all_epithelial(44;8.95e-09)|Lung NSC(174;0.000845)|all_lung(145;0.00144)|all_neural(114;0.0299)|Colorectal(31;0.0585)|Melanoma(40;0.123)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;9.16e-06)|Epithelial(32;1.21e-05)|all cancers(32;1.63e-05)		CACACGCTCCTGAATTTCTGC	0.652		NaN											0	0	0	0.00361	0	88	45				
NLRP6	171389	broad.mit.edu	37	11	285201	285201	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:285201A>G	uc010qvs.1	+	8	2576	c.2576A>G	c.(2575-2577)CAG>CGG	p.Q859R	NLRP6_uc010qvt.1_Missense_Mutation_p.Q858R	NM_138329	NP_612202	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	859	LRR 5.					cytoplasm	ATP binding			upper_aerodigestive_tract(1)|skin(1)	2		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		CAGTCACTACAGGAGCTTCAG	0.622		NaN											0	0	0	0.006214	0	7	14				
CARS	833	broad.mit.edu	37	11	3026647	3026647	+	Silent	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:3026647C>T	uc001lxh.2	-	19	1991	c.1917G>A	c.(1915-1917)GTG>GTA	p.V639V	CARS_uc009ydu.2_RNA|CARS_uc001lxe.2_Silent_p.V629V|CARS_uc001lxf.2_Silent_p.V722V|CARS_uc001lxg.2_Silent_p.V639V|CARS_uc010qxo.1_Silent_p.V722V|CARS_uc010qxp.1_Silent_p.V652V	NM_001751	NP_001742	P49589	SYCC_HUMAN	cysteinyl-tRNA synthetase isoform b	639					cysteinyl-tRNA aminoacylation	cytoplasm|cytosol	ATP binding|cysteine-tRNA ligase activity|metal ion binding|protein homodimerization activity|protein homodimerization activity|tRNA binding|tRNA binding		CARS/ALK(5)	soft_tissue(5)|ovary(2)	7		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00317)|LUSC - Lung squamous cell carcinoma(625;0.218)	L-Cysteine(DB00151)	CTACCAGTTTCACCACTGTGG	0.408		NaN	T	ALK	ALCL								0	0	0	0.003755	0	30	39				
OR52N5	390075	broad.mit.edu	37	11	5799737	5799737	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:5799737T>A	uc010qzn.1	-	1	128	c.128A>T	c.(127-129)TAC>TTC	p.Y43F	TRIM5_uc001mbq.1_Intron|TRIM22_uc009yet.1_Intron	NM_001001922	NP_001001922	Q8NH56	O52N5_HUMAN	olfactory receptor, family 52, subfamily N,	43	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;3.05e-11)|LUSC - Lung squamous cell carcinoma(625;0.112)|BRCA - Breast invasive adenocarcinoma(625;0.135)|Lung(200;0.195)		GAAGATGATGTACATTGTGCA	0.408		NaN											0	0	0	0.00361	0	44	36				
RRP8	23378	broad.mit.edu	37	11	6621449	6621449	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:6621449C>T	uc001med.2	-	7	1377	c.1298G>A	c.(1297-1299)GGG>GAG	p.G433E		NM_015324	NP_056139	O43159	RRP8_HUMAN	ribosomal RNA processing 8, methyltransferase,	433					chromatin modification|chromatin silencing at rDNA|rRNA processing|transcription, DNA-dependent	chromatin silencing complex|nucleolus|rDNA heterochromatin	methylated histone residue binding|S-adenosylmethionine-dependent methyltransferase activity				0						CAGAGGGGGCCCAGTCTTTTG	0.522		NaN											0	0	0	0.007291	0	24	21				
DCHS1	8642	broad.mit.edu	37	11	6652344	6652344	+	Silent	SNP	T	T	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:6652344T>A	uc001mem.1	-	9	4280	c.3870A>T	c.(3868-3870)ACA>ACT	p.T1290T		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	1290	Cadherin 12.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GAGCACTCAGTGTCAGCACAT	0.622		NaN											0	0	0	0.004007	0	13	21				
E2F8	79733	broad.mit.edu	37	11	19253864	19253864	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:19253864A>G	uc001mpm.2	-	7	1505	c.983T>C	c.(982-984)ATC>ACC	p.I328T	E2F8_uc009yhv.2_RNA|E2F8_uc001mpn.3_Missense_Mutation_p.I328T	NM_024680	NP_078956	A0AVK6	E2F8_HUMAN	E2F family member 8	328	Potential.				cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						AACTTTCTTGATAAGATCCAG	0.358		NaN											0	0	0	0.003755	0	31	21				
CRY2	1408	broad.mit.edu	37	11	45891186	45891186	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:45891186C>T	uc010rgn.1	+	7	1097	c.1075C>T	c.(1075-1077)CCC>TCC	p.P359S	CRY2_uc009ykw.2_Missense_Mutation_p.P277S|CRY2_uc010rgo.1_Missense_Mutation_p.P81S	NM_021117	NP_066940	Q49AN0	CRY2_HUMAN	cryptochrome 2 (photolyase-like) isoform 1	338	FAD-binding.				DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	blue light photoreceptor activity|damaged DNA binding|DNA photolyase activity|nucleotide binding|protein binding|single-stranded DNA binding			central_nervous_system(1)	1						CATCCAGATCCCCTGGGACCG	0.587		NaN											0	0	0	0.00361	0	43	161				
OR4A16	81327	broad.mit.edu	37	11	55111294	55111294	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:55111294G>A	uc010rie.1	+	1	618	c.618G>A	c.(616-618)ATG>ATA	p.M206I		NM_001005274	NP_001005274	Q8NH70	O4A16_HUMAN	olfactory receptor, family 4, subfamily A,	206	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(2)|pancreas(1)	3						TAATTTGTATGGTCATCTTTA	0.438		NaN											0	0	0	0.00245	0	15	86				
HRASLS5	117245	broad.mit.edu	37	11	63233662	63233662	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:63233662T>C	uc001nwy.2	-	5	841	c.667A>G	c.(667-669)ATC>GTC	p.I223V	HRASLS5_uc001nwz.2_Missense_Mutation_p.I213V|HRASLS5_uc010rmq.1_Missense_Mutation_p.I223V|HRASLS5_uc009yos.2_RNA	NM_054108	NP_473449	Q96KN8	HRSL5_HUMAN	HRAS-like suppressor family, member 5 isoform 1	223										ovary(1)	1						TACTGCACGATCTTGTTGACC	0.527		NaN											0	0	0	0.006122	0	17	46				
PRDX5	25824	broad.mit.edu	37	11	64085714	64085714	+	Silent	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:64085714G>A	uc001nzu.2	+	1	146	c.27G>A	c.(25-27)CTG>CTA	p.L9L	TRMT112_uc001nzt.2_5'Flank|PRDX5_uc001nzv.2_Silent_p.L9L|PRDX5_uc001nzw.2_Silent_p.L9L|PRDX5_uc001nzx.2_5'Flank	NM_012094	NP_036226	P30044	PRDX5_HUMAN	peroxiredoxin 5 isoform a precursor	9					cell redox homeostasis|cellular response to reactive oxygen species|inflammatory response|negative regulation of apoptosis	cytosolic part|mitochondrion|peroxisome	caspase inhibitor activity|peroxidase activity|peroxiredoxin activity			breast(1)	1					Auranofin(DB00995)	TGTGCGCCCTGAGACGCTCAG	0.701		NaN											0	0	0	0.002445	0	26	95				
NRXN2	9379	broad.mit.edu	37	11	64480980	64480980	+	Silent	SNP	C	C	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:64480980C>A	uc001oar.2	-	3	631	c.192G>T	c.(190-192)GCG>GCT	p.A64A	NRXN2_uc001oas.2_Silent_p.A64A	NM_015080	NP_055895	P58401	NRX2B_HUMAN	neurexin 2 isoform alpha-1 precursor	130	Extracellular (Potential).|Laminin G-like.				cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						AGAGCAGCAGCGCGCGCGTGG	0.751		NaN											1	0	2.35188e-11	0.006122	2.52239e-11	13	5				
DKFZp761E198	91056	broad.mit.edu	37	11	65547232	65547232	+	Silent	SNP	T	T	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:65547232T>A	uc001ofo.3	-	1	591	c.561A>T	c.(559-561)GCA>GCT	p.A187A		NM_138368	NP_612377	Q2VPB7	YK046_HUMAN	hypothetical protein LOC91056	187	Leu-rich.						protein binding				0				READ - Rectum adenocarcinoma(159;0.167)		CCTCCTCAGCTGCCGGCCAGC	0.662		NaN											0	0	0	0.00361	0	141	115				
B3GNT1	11041	broad.mit.edu	37	11	66114948	66114948	+	Silent	SNP	C	C	G	rs146812867	byFrequency	TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:66114948C>G	uc001ohr.2	-	1	214	c.69G>C	c.(67-69)GCG>GCC	p.A23A	BRMS1_uc001ohp.1_5'Flank|BRMS1_uc001oho.1_5'Flank	NM_006876	NP_006867	O43505	B3GN1_HUMAN	UDP-GlcNAc:betaGal	23	Helical; Signal-anchor for type II membrane protein; (Potential).				poly-N-acetyllactosamine biosynthetic process	integral to Golgi membrane	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity				0						GCTGCAGCATCGCCACCAGCA	0.647		NaN											0	0	0	0.00499	0	17	23				
TCIRG1	10312	broad.mit.edu	37	11	67816717	67816717	+	Missense_Mutation	SNP	C	C	T	rs141780643		TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:67816717C>T	uc001one.2	+	15	1951	c.1843C>T	c.(1843-1845)CTC>TTC	p.L615F	TCIRG1_uc001ong.2_Missense_Mutation_p.L399F|TCIRG1_uc001onh.2_Missense_Mutation_p.L317F|TCIRG1_uc001oni.2_Missense_Mutation_p.L119F|TCIRG1_uc009ysd.2_5'Flank	NM_006019	NP_006010	Q13488	VPP3_HUMAN	T-cell, immune regulator 1 isoform a	615	Helical; (Potential).				ATP hydrolysis coupled proton transport|cellular defense response|cellular iron ion homeostasis|insulin receptor signaling pathway|positive regulation of cell proliferation|transferrin transport	apical plasma membrane|endosome membrane|integral to plasma membrane|proton-transporting two-sector ATPase complex, proton-transporting domain	hydrogen ion transmembrane transporter activity			ovary(1)	1						CAACATGTTCCTCTTCTCCCA	0.657		NaN											0	0	0	0.00361	0	51	175				
LRP5	4041	broad.mit.edu	37	11	68207303	68207303	+	Silent	SNP	G	G	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:68207303G>T	uc001ont.2	+	21	4482	c.4407G>T	c.(4405-4407)GGG>GGT	p.G1469G	LRP5_uc009ysg.2_Silent_p.G879G	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	1469	Cytoplasmic (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						GCCGGGGCGGGGTGCCCCTCT	0.632		NaN											1	0	9.45814e-24	0.004878	1.05391e-23	28	28				
MYO7A	4647	broad.mit.edu	37	11	76915135	76915135	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:76915135A>G	uc001oyb.2	+	39	5613	c.5341A>G	c.(5341-5343)ATG>GTG	p.M1781V	MYO7A_uc001oyc.2_Missense_Mutation_p.M1743V|MYO7A_uc001oye.2_RNA	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	1781	MyTH4 2.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						GCTCAAGTACATGGGCGACTA	0.617		NaN											0	0	0	0.000602	0	4	13				
MLL	4297	broad.mit.edu	37	11	118368671	118368671	+	Nonsense_Mutation	SNP	T	T	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08			T	G	T	T		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:118368671T>G	uc001pta.2	+	21	5699	c.5676T>G	c.(5674-5676)TAT>TAG	p.Y1892*	MLL_uc001ptb.2_Nonsense_Mutation_p.Y1895*	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1892					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		GTTTACTATATATTGGCCAAA	0.378		NaN	T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								0	0	0	0.003163	0	13	27		Valid		
HSPA8	3312	broad.mit.edu	37	11	122929417	122929417	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:122929417G>A	uc001pyo.2	-	7	1523	c.1445C>T	c.(1444-1446)GCC>GTC	p.A482V	HSPA8_uc009zbc.2_Missense_Mutation_p.A246V|HSPA8_uc001pyp.2_Intron|HSPA8_uc010rzu.1_Missense_Mutation_p.A405V	NM_006597	NP_006588	P11142	HSP7C_HUMAN	heat shock 70kDa protein 8 isoform 1	482					cellular membrane organization|interspecies interaction between organisms|mRNA metabolic process|negative regulation of transcription, DNA-dependent|neurotransmitter secretion|post-Golgi vesicle-mediated transport|protein folding|response to unfolded protein|transcription, DNA-dependent	cell surface|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|melanosome|plasma membrane|ribonucleoprotein complex	ATP binding|ATPase activity, coupled|protein binding			central_nervous_system(7)|lung(1)	8		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		TATACCATTGGCATCAATGTC	0.448		NaN											0	0	0	0.009535	0	29	35				
WNK1	65125	broad.mit.edu	37	12	989117	989117	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:989117G>T	uc001qio.3	+	11	3259	c.2752G>T	c.(2752-2754)GCA>TCA	p.A918S	WNK1_uc001qip.3_Intron|WNK1_uc001qir.3_Intron	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	918					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			CCTACAACCAGCAGTTCAGTC	0.512		NaN											1	0	3.86236e-30	0.00361	4.3604e-30	39	41				
WNK1	65125	broad.mit.edu	37	12	994164	994164	+	Silent	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:994164C>T	uc001qio.3	+	19	4701	c.4194C>T	c.(4192-4194)CTC>CTT	p.L1398L	WNK1_uc001qip.3_Silent_p.L1151L|WNK1_uc001qir.3_Silent_p.L571L	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1398					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			CAGGTGGTCTCCCCATACCAC	0.478		NaN											0	0	0	0.004878	0	34	34				
SCNN1A	6337	broad.mit.edu	37	12	6471317	6471317	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:6471317T>C	uc001qnx.2	-	4	1064	c.775A>G	c.(775-777)ATC>GTC	p.I259V	SCNN1A_uc001qnv.2_5'UTR|SCNN1A_uc001qnw.2_Missense_Mutation_p.I318V|SCNN1A_uc010sfb.1_Missense_Mutation_p.I282V	NM_001038	NP_001029	P37088	SCNNA_HUMAN	sodium channel, nonvoltage-gated 1 alpha isoform	259	Extracellular (By similarity).				excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding				0					Amiloride(DB00594)|Triamterene(DB00384)	CTCGACAGGATGTTGATGTAG	0.572		NaN											0	0	0	0.002096	0	29	91				
NECAP1	25977	broad.mit.edu	37	12	8245362	8245362	+	Silent	SNP	C	C	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:8245362C>G	uc001qtx.2	+	5	552	c.474C>G	c.(472-474)ACC>ACG	p.T158T	NECAP1_uc001qty.2_Silent_p.T16T	NM_015509	NP_056324	Q8NC96	NECP1_HUMAN	NECAP endocytosis associated 1	158					endocytosis|protein transport	clathrin coated vesicle membrane|plasma membrane				ovary(1)	1				Kidney(36;0.0915)		AAGGACAAACCATCAAGTTGT	0.403		NaN											0	0	0	0.001368	0	9	13				
KIF21A	55605	broad.mit.edu	37	12	39763563	39763563	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:39763563G>T	uc001rly.2	-	3	564	c.418C>A	c.(418-420)CCA>ACA	p.P140T	KIF21A_uc001rlx.2_Missense_Mutation_p.P140T|KIF21A_uc001rlz.2_Missense_Mutation_p.P140T|KIF21A_uc010skl.1_Missense_Mutation_p.P140T|KIF21A_uc001rma.1_Missense_Mutation_p.P140T	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	140	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				TTAAAATCTGGAGCAGGAAGC	0.299		NaN											1	0	2.56e-06	0.009096	2.64e-06	4	8				
NELL2	4753	broad.mit.edu	37	12	44917077	44917077	+	Silent	SNP	A	A	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:44917077A>G	uc001rog.2	-	17	2590	c.1995T>C	c.(1993-1995)TGT>TGC	p.C665C	NELL2_uc001rof.3_Silent_p.C664C|NELL2_uc001roh.2_Silent_p.C665C|NELL2_uc009zkd.2_Silent_p.C617C|NELL2_uc010skz.1_Silent_p.C715C|NELL2_uc010sla.1_Silent_p.C688C|NELL2_uc001roi.1_Silent_p.C665C	NM_001145108	NP_001138580	Q99435	NELL2_HUMAN	NEL-like protein 2 isoform b precursor	665	VWFC 3.				cell adhesion	extracellular region	calcium ion binding|protein binding|structural molecule activity			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4	Lung SC(27;0.192)	Lung NSC(34;0.144)		GBM - Glioblastoma multiforme(48;0.092)		TACCAACCTGACATGAGCACA	0.259		NaN											0	0	0	0.004289	0	35	65				
ARID2	196528	broad.mit.edu	37	12	46287258	46287258	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08			A	T	A	A		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:46287258A>T	uc001ros.1	+	19	5203	c.5203A>T	c.(5203-5205)AAT>TAT	p.N1735Y	ARID2_uc001ror.2_Missense_Mutation_p.N1735Y|ARID2_uc009zkg.1_Missense_Mutation_p.N1191Y|ARID2_uc009zkh.1_Missense_Mutation_p.N1362Y|ARID2_uc001rou.1_Missense_Mutation_p.N1069Y	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1735					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		GGCCATTGTGAATCATCCCAG	0.393		NaN											0	0	0	0.009096	0	3	20		Valid		
DHH	50846	broad.mit.edu	37	12	49488197	49488197	+	Silent	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:49488197G>A	uc001rtf.2	-	1	406	c.99C>T	c.(97-99)CGC>CGT	p.R33R		NM_021044	NP_066382	O43323	DHH_HUMAN	desert hedgehog preproprotein	33					cell-cell signaling|proteolysis	extracellular space|plasma membrane	calcium ion binding|peptidase activity|zinc ion binding			lung(1)|breast(1)	2						GCGCATAGCGGCGCCGGCCAA	0.602		NaN											0	0	0	0.000978	0	11	26				
ZNF385A	25946	broad.mit.edu	37	12	54765302	54765302	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:54765302T>C	uc001sfw.1	-	4	742	c.559A>G	c.(559-561)AAG>GAG	p.K187E	ZNF385A_uc001sfv.1_Missense_Mutation_p.K168E|ZNF385A_uc009zno.1_RNA|ZNF385A_uc010sov.1_Intron|ZNF385A_uc001sfx.1_Missense_Mutation_p.K187E|ZNF385A_uc001sfy.3_Missense_Mutation_p.K207E|ZNF385A_uc001sfz.3_Intron	NM_015481	NP_056296	Q96PM9	Z385A_HUMAN	zinc finger protein 385A isoform c	187	Matrin-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			ovary(1)	1						ACAGCCACCTTGCACAGAGCA	0.612		NaN											0	0	0	0.00361	0	96	83				
ZC3H10	84872	broad.mit.edu	37	12	56515604	56515604	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:56515604T>C	uc001sjp.1	+	3	1447	c.1258T>C	c.(1258-1260)TAC>CAC	p.Y420H		NM_032786	NP_116175	Q96K80	ZC3HA_HUMAN	zinc finger CCCH-type containing 10	420							nucleic acid binding|zinc ion binding				0			OV - Ovarian serous cystadenocarcinoma(18;0.12)			CATGGTGACTTACCCTATCGC	0.602		NaN											0	0	0	0.00361	0	45	31				
LRP1	4035	broad.mit.edu	37	12	57572754	57572754	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:57572754G>T	uc001snd.2	+	28	5154	c.4688G>T	c.(4687-4689)TGC>TTC	p.C1563F		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	1563	EGF-like 7.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	ACCGTGTCCTGCGCCTGCCCC	0.632		NaN											1	0	1.39691e-52	0.00361	1.62405e-52	87	119				
LRP1	4035	broad.mit.edu	37	12	57598266	57598266	+	Silent	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:57598266C>T	uc001snd.2	+	71	11491	c.11025C>T	c.(11023-11025)GGC>GGT	p.G3675G		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	3675	Extracellular (Potential).|LDL-receptor class A 29.				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	AGTGCGATGGCGAGGATGACT	0.632		NaN											0	0	0	0.002836	0	30	107				
MBD6	114785	broad.mit.edu	37	12	57919889	57919889	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:57919889G>C	uc001soj.1	+	6	1362	c.1138G>C	c.(1138-1140)GGC>CGC	p.G380R	MBD6_uc001sok.1_Missense_Mutation_p.G247R|MBD6_uc001sol.1_5'Flank	NM_052897	NP_443129	Q96DN6	MBD6_HUMAN	methyl-CpG binding domain protein 6	380	Pro-rich.					chromosome|nucleus	chromatin binding|DNA binding			central_nervous_system(3)|ovary(1)	4						AGAAGGGAGAGGCCCTCAAAC	0.617		NaN											0	0	0	0.00361	0	77	77				
USP15	9958	broad.mit.edu	37	12	62785202	62785202	+	Silent	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:62785202G>A	uc001src.1	+	16	2235	c.2226G>A	c.(2224-2226)AGG>AGA	p.R742R	USP15_uc001srb.1_Silent_p.R713R	NM_006313	NP_006304	Q9Y4E8	UBP15_HUMAN	ubiquitin specific peptidase 15	742					protein deubiquitination|ubiquitin-dependent protein catabolic process		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)|lung(1)	3			GBM - Glioblastoma multiforme(1;0.000276)	GBM - Glioblastoma multiforme(28;0.0622)		GGCAGCTTAGGCTAGATGGTA	0.343		NaN											0	0	0	0.00278	0	17	9				
WIF1	11197	broad.mit.edu	37	12	65514281	65514281	+	Silent	SNP	A	A	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:65514281A>G	uc001ssk.2	-	2	349	c.204T>C	c.(202-204)CAT>CAC	p.H68H		NM_007191	NP_009122	Q9Y5W5	WIF1_HUMAN	WNT inhibitory factor 1 precursor	68	WIF.				multicellular organismal development|Wnt receptor signaling pathway	extracellular region	protein tyrosine kinase activity			ovary(2)|lung(1)|skin(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0231)		TTCTGAAATCATGTGTAAAAG	0.378		NaN	T	HMGA2	pleomorphic salivary gland adenoma								0	0	0	0.004656	0	20	19				
TMBIM4	51643	broad.mit.edu	37	12	66531850	66531850	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:66531850G>A	uc001stc.2	-	7	683	c.607C>T	c.(607-609)CAT>TAT	p.H203Y	LLPH_uc010ssx.1_RNA|TMBIM4_uc001std.2_Missense_Mutation_p.H172Y|TMBIM4_uc009zqr.2_Missense_Mutation_p.H250Y|TMBIM4_uc001ste.2_RNA|TMBIM4_uc001stf.2_3'UTR|TMBIM4_uc009zqs.2_3'UTR	NM_016056	NP_057140	Q9HC24	TMBI4_HUMAN	transmembrane BAX inhibitor motif containing 4	203						integral to membrane	protein binding			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(28;0.0745)		GACAGTTTATGCATCAGTGAG	0.413		NaN											0	0	0	0.008291	0	8	33				
LYZ	4069	broad.mit.edu	37	12	69746950	69746950	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:69746950G>A	uc001suw.2	+	4	453	c.398G>A	c.(397-399)CGT>CAT	p.R133H		NM_000239	NP_000230	P61626	LYSC_HUMAN	lysozyme precursor	133					cell wall macromolecule catabolic process|cytolysis|defense response to bacterium|inflammatory response	extracellular space	lysozyme activity|protein binding				0	all_epithelial(5;2.98e-35)|Lung NSC(4;9.93e-33)|all_lung(4;5.66e-31)|Breast(13;2.56e-06)|Esophageal squamous(21;0.187)		Epithelial(6;8.26e-19)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;9.68e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00503)|OV - Ovarian serous cystadenocarcinoma(12;0.00691)|LUSC - Lung squamous cell carcinoma(43;0.24)|Kidney(9;0.241)			TGGAGAAATCGTTGTCAAAAC	0.398		NaN											0	0	0	0.002836	0	27	40				
ALX1	8092	broad.mit.edu	37	12	85694982	85694982	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:85694982C>A	uc001tae.3	+	4	714	c.710C>A	c.(709-711)ACT>AAT	p.T237N		NM_006982	NP_008913	Q15699	ALX1_HUMAN	cartilage paired-class homeoprotein 1	237					brain development|cartilage condensation|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(134;0.134)		TCTGTGGTTACTTCATGCATG	0.408		NaN											1	0	1.04594e-18	0.00623	1.15349e-18	30	39				
PAH	5053	broad.mit.edu	37	12	103246694	103246694	+	Silent	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:103246694G>A	uc001tjq.1	-	8	1213	c.741C>T	c.(739-741)GGC>GGT	p.G247G		NM_000277	NP_000268	P00439	PH4H_HUMAN	phenylalanine hydroxylase	247			G -> V (in PKU; haplotype 4).		catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			ovary(4)	4					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	AGGAAAGCAGGCCAGCCACAG	0.537		NaN											0	0	0	0.003163	0	11	18				
FICD	11153	broad.mit.edu	37	12	108912880	108912880	+	Silent	SNP	A	A	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:108912880A>G	uc001tmx.1	+	3	1151	c.1005A>G	c.(1003-1005)GTA>GTG	p.V335V		NM_007076	NP_009007	Q9BVA6	FICD_HUMAN	Huntingtin interacting protein E	335	Fido.				negative regulation of Rho GTPase activity	integral to membrane	binding|protein adenylyltransferase activity				0						AGGAGTTTGTACAGTGGCTCA	0.542		NaN											0	0	0	0.003214	0	43	38				
CIT	11113	broad.mit.edu	37	12	120288005	120288006	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:120288005_120288006GG>TT	uc001txi.1	-	5	541_542	c.488_489CC>AA	c.(487-489)GCC>GAA	p.A163E	CIT_uc001txj.1_Missense_Mutation_p.A163E	NM_007174	NP_009105	O14578	CTRO_HUMAN	citron	163	Protein kinase.				intracellular signal transduction		ATP binding|metal ion binding|protein serine/threonine kinase activity|SH3 domain binding|small GTPase regulator activity			ovary(6)|urinary_tract(1)|lung(1)|breast(1)|skin(1)	10	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)	Myeloproliferative disorder(1001;0.0255)		BRCA - Breast invasive adenocarcinoma(302;0.211)		TGTCCTGAAAGGCATACTGTAA	0.426		NaN											0	0	0	0.004672	0	60	75				
KDM2B	84678	broad.mit.edu	37	12	121947735	121947735	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:121947735C>A	uc001uat.2	-	11	1386	c.1282G>T	c.(1282-1284)GAG>TAG	p.E428*	KDM2B_uc001uar.2_Nonsense_Mutation_p.E19*|KDM2B_uc001uas.2_Nonsense_Mutation_p.E397*|KDM2B_uc001uau.2_Nonsense_Mutation_p.E311*|KDM2B_uc001uav.3_Nonsense_Mutation_p.E338*	NM_032590	NP_115979	Q8NHM5	KDM2B_HUMAN	F-box and leucine-rich repeat protein 10 isoform	428	Glu-rich.				embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			ovary(1)|skin(1)	2						CCCTCGCcctcctcgtccttc	0.562		NaN											1	0	4.14922e-12	0.004007	4.4724e-12	12	34				
BRI3BP	140707	broad.mit.edu	37	12	125497182	125497182	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:125497182G>A	uc001uha.1	+	2	459	c.316G>A	c.(316-318)GTC>ATC	p.V106I		NM_080626	NP_542193	Q8WY22	BRI3B_HUMAN	BRI3-binding protein	106						integral to membrane|mitochondrial outer membrane				ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.35e-05)|Epithelial(86;0.000426)|all cancers(50;0.00576)		TGGACTTGACGGTAGGTGTAG	0.488		NaN											0	0	0	0.009535	0	25	112				
ATP8A2	51761	broad.mit.edu	37	13	26129158	26129158	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr13:26129158C>A	uc001uqk.2	+	13	1357	c.1215C>A	c.(1213-1215)GAC>GAA	p.D405E	ATP8A2_uc010tdi.1_Missense_Mutation_p.D365E|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc001uql.1_Missense_Mutation_p.D365E	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	365	Cytoplasmic (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		TAGGAAATGACACTCCTGCCA	0.408		NaN											1	0	2.74318e-10	0.006214	2.92016e-10	7	22				
KL	9365	broad.mit.edu	37	13	33628356	33628356	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr13:33628356G>C	uc001uus.2	+	2	1280	c.1272G>C	c.(1270-1272)AAG>AAC	p.K424N	KL_uc001uur.1_Missense_Mutation_p.K117N	NM_004795	NP_004786	Q9UEF7	KLOT_HUMAN	klotho precursor	424	Glycosyl hydrolase-1 1.|Extracellular (Potential).				aging|carbohydrate metabolic process|insulin receptor signaling pathway|positive regulation of bone mineralization	extracellular space|extracellular space|integral to membrane|integral to plasma membrane|membrane fraction|soluble fraction	beta-glucosidase activity|beta-glucuronidase activity|cation binding|fibroblast growth factor binding|hormone activity|signal transducer activity|vitamin D binding			large_intestine(1)|ovary(1)|skin(1)	3	all_epithelial(80;0.133)	Ovarian(182;1.78e-06)|Breast(139;4.08e-05)|Hepatocellular(188;0.00886)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;7.13e-230)|all cancers(112;1.33e-165)|OV - Ovarian serous cystadenocarcinoma(117;1.09e-113)|Epithelial(112;3.79e-112)|Lung(94;8.52e-27)|LUSC - Lung squamous cell carcinoma(192;1.4e-13)|Kidney(163;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(186;5.63e-08)|BRCA - Breast invasive adenocarcinoma(63;1.41e-05)		GGACCACCAAGAGAGATGATG	0.393		NaN											0	0	0	0.00333	0	22	19				
HTR2A	3356	broad.mit.edu	37	13	47409473	47409473	+	Silent	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr13:47409473G>A	uc001vbq.2	-	3	1049	c.915C>T	c.(913-915)TCC>TCT	p.S305S	HTR2A_uc001vbr.2_Silent_p.S205S|HTR2A_uc010acr.2_Silent_p.S305S	NM_000621	NP_000612	P28223	5HT2A_HUMAN	5-hydroxytryptamine receptor 2A isoform 1	305	Cytoplasmic (By similarity).				ERK1 and ERK2 cascade|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|release of sequestered calcium ion into cytosol|response to drug|synaptic transmission	integral to plasma membrane	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding|drug binding|phosphatidylinositol phospholipase C activity|serotonin binding|serotonin receptor activity			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6		all_lung(13;7.2e-10)|Lung NSC(96;3.77e-07)|Breast(56;2.06e-05)|Prostate(109;0.00116)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|Myeloproliferative disorder(33;0.0333)		GBM - Glioblastoma multiforme(144;4.67e-05)|COAD - Colon adenocarcinoma(199;0.224)	Aripiprazole(DB01238)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cisapride(DB00604)|Clomipramine(DB01242)|Clozapine(DB00363)|Cyclobenzaprine(DB00924)|Cyproheptadine(DB00434)|Dihydroergotamine(DB00320)|Donepezil(DB00843)|Epinastine(DB00751)|Ergotamine(DB00696)|Fluvoxamine(DB00176)|Mesoridazine(DB00933)|Methysergide(DB00247)|Mianserin(DB06148)|Minaprine(DB00805)|Mirtazapine(DB00370)|Nefazodone(DB01149)|Olanzapine(DB00334)|Paliperidone(DB01267)|Paroxetine(DB00715)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Risperidone(DB00734)|Sertindole(DB06144)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	TGCCTGTGTAGGACCCTGGCT	0.522		NaN											0	0	0	0.001168	0	6	4				
RB1	5925	broad.mit.edu	37	13	49050846	49050846	+	Nonsense_Mutation	SNP	A	A	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08			A	T	A	A		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr13:49050846A>T	uc001vcb.2	+	25	2696	c.2530A>T	c.(2530-2532)AAG>TAG	p.K844*		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	844	Interaction with LIMD1.|Domain C; mediates interaction with E4F1.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GACTTCTGAGAAGTTCCAGAA	0.363		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			0	0	0	0.001984	0	5	4		Valid		
DCT	1638	broad.mit.edu	37	13	95117984	95117984	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr13:95117984C>T	uc001vlv.3	-	4	1193	c.766G>A	c.(766-768)GTG>ATG	p.V256M	DCT_uc010afh.2_Missense_Mutation_p.V256M	NM_001922	NP_001913	P40126	TYRP2_HUMAN	dopachrome tautomerase isoform 1	256	Lumenal, melanosome (Potential).				epidermis development|melanin biosynthetic process from tyrosine	cytosol|integral to membrane|melanosome membrane|microsome	copper ion binding|dopachrome isomerase activity|oxidoreductase activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;3.71e-42)|all_epithelial(2;3.76e-31)|all_lung(2;5.16e-14)|Lung NSC(4;1.33e-13)|Breast(118;0.0013)|Hepatocellular(115;0.00886)|Renal(2;0.00988)		COAD - Colon adenocarcinoma(199;7.07e-05)|GBM - Glioblastoma multiforme(99;0.000472)		TCTGTACACACATCACACTCG	0.493		NaN											0	0	0	0.004656	0	20	40				
IPO5	3843	broad.mit.edu	37	13	98641409	98641409	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr13:98641409A>G	uc001vnf.1	+	4	523	c.458A>G	c.(457-459)CAC>CGC	p.H153R	IPO5_uc001vne.2_Missense_Mutation_p.H171R|IPO5_uc010tik.1_Intron|IPO5_uc010til.1_Missense_Mutation_p.H93R	NM_002271	NP_002262	O00410	IPO5_HUMAN	importin 5	153					interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			ovary(1)|lung(1)|skin(1)	3						GCTGCCCTTCACATTTTCTGG	0.373		NaN											0	0	0	0.000978	0	10	10				
EFNB2	1948	broad.mit.edu	37	13	107145643	107145643	+	Silent	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr13:107145643C>T	uc001vqi.2	-	5	772	c.747G>A	c.(745-747)TTG>TTA	p.L249L		NM_004093	NP_004084	P52799	EFNB2_HUMAN	ephrin B2 precursor	249	Helical; (Potential).				cell differentiation|cell-cell signaling|interspecies interaction between organisms|nervous system development	integral to plasma membrane	ephrin receptor binding			ovary(1)	1	Lung NSC(43;0.015)|all_neural(89;0.0741)|Lung SC(71;0.14)|Medulloblastoma(90;0.169)					GGTACTTCAGCAAGAGGACCA	0.522		NaN											0	0	0	0.00361	0	57	111				
OR4M1	441670	broad.mit.edu	37	14	20249060	20249060	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr14:20249060C>G	uc010tku.1	+	1	579	c.579C>G	c.(577-579)TTC>TTG	p.F193L		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	193	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CCAACACCTTCCCAGAGGAGT	0.478		NaN											0	0	0	0.003755	0	28	82				
SUPT16H	11198	broad.mit.edu	37	14	21834657	21834657	+	Silent	SNP	G	G	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr14:21834657G>T	uc001wao.2	-	8	1326	c.987C>A	c.(985-987)GTC>GTA	p.V329V		NM_007192	NP_009123	Q9Y5B9	SP16H_HUMAN	chromatin-specific transcription elongation	329					DNA repair|DNA replication|nucleosome disassembly|positive regulation of transcription elongation, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|nucleoplasm	GTP binding				0	all_cancers(95;0.00115)		Epithelial(56;1.62e-06)|all cancers(55;1.49e-05)	GBM - Glioblastoma multiforme(265;0.0159)		CCACGTCCATGACAGCGTTAT	0.348		NaN											1	0	4.7546e-09	0.004007	4.97494e-09	12	85				
EFS	10278	broad.mit.edu	37	14	23826494	23826494	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr14:23826494T>A	uc001wjo.2	-	6	2235	c.1627A>T	c.(1627-1629)ACA>TCA	p.T543S	EFS_uc001wjp.2_Missense_Mutation_p.T450S|EFS_uc010tnm.1_Missense_Mutation_p.T374S	NM_005864	NP_005855	O43281	EFS_HUMAN	embryonal Fyn-associated substrate isoform 1	543					cell adhesion|intracellular signal transduction	cytoplasm	SH3 domain binding			large_intestine(1)	1	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00649)		GCCAGTTCTGTTACACACTGC	0.612		NaN											0	0	0	0.004289	0	31	101				
DHRS4L1	728635	broad.mit.edu	37	14	24518021	24518021	+	Splice_Site	SNP	G	G	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr14:24518021G>C	uc010alc.2	+	8	675	c.675_splice	c.e8+1	p.M225_splice	DHRS4L1_uc010tnu.1_Splice_Site	NM_001082488	NP_001075957	P0CG22	DR4L1_HUMAN	dehydrogenase/reductase (SDR family) member 4								binding|oxidoreductase activity				0						CAGCAGGATGGTGAGGAAGGG	0.547		NaN											0	0	0	0.00632	0	17	109				
RALGAPA1	253959	broad.mit.edu	37	14	36277976	36277976	+	Silent	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr14:36277976C>T	uc001wti.2	-	1	457	c.66G>A	c.(64-66)AAG>AAA	p.K22K	RALGAPA1_uc001wtj.2_Silent_p.K22K|RALGAPA1_uc010tpv.1_Silent_p.K22K|RALGAPA1_uc010tpw.1_Silent_p.K22K	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	22					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						TCAGTGCGTCCTTCTTGGTGT	0.557		NaN											0	0	0	0.004289	0	28	25				
SSTR1	6751	broad.mit.edu	37	14	38679681	38679681	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr14:38679681T>C	uc001wul.1	+	3	1704	c.1087T>C	c.(1087-1089)TAC>CAC	p.Y363H	SSTR1_uc010amu.1_Intron	NM_001049	NP_001040	P30872	SSR1_HUMAN	somatostatin receptor 1	363	Cytoplasmic (Potential).				digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			central_nervous_system(3)|ovary(1)|lung(1)	5	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	GAGCCGTGCCTACAGTGTGGA	0.617		NaN											0	0	0	0.00361	0	118	62				
SYNE2	23224	broad.mit.edu	37	14	64408416	64408416	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr14:64408416A>G	uc001xgm.2	+	4	375	c.145A>G	c.(145-147)ACT>GCT	p.T49A	SYNE2_uc001xgk.2_Missense_Mutation_p.T49A|SYNE2_uc001xgl.2_Missense_Mutation_p.T49A	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	49	CH 1.|Cytoplasmic (Potential).|Actin-binding.				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		TCTGCAGCACACTTCTCCCTC	0.373		NaN											0	0	0	0.004482	0	7	42				
C14orf50	145376	broad.mit.edu	37	14	65031546	65031546	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr14:65031546C>T	uc001xhl.1	+	4	356	c.260C>T	c.(259-261)GCT>GTT	p.A87V		NM_172365	NP_758953	Q96LQ0	CN050_HUMAN	hypothetical protein LOC145376	87										skin(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.00382)|all cancers(60;0.00427)|BRCA - Breast invasive adenocarcinoma(234;0.0488)		GATGGTCCAGCTTCAGACAGG	0.408		NaN											0	0	0	0.00361	0	41	67				
PLEKHG3	26030	broad.mit.edu	37	14	65203599	65203599	+	Silent	SNP	C	C	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr14:65203599C>G	uc001xho.1	+	13	1643	c.1374C>G	c.(1372-1374)CTC>CTG	p.L458L	PLEKHG3_uc001xhn.1_Silent_p.L402L|PLEKHG3_uc001xhp.2_Silent_p.L458L|PLEKHG3_uc010aqh.1_5'UTR|PLEKHG3_uc001xhq.1_5'Flank	NM_015549	NP_056364	A1L390	PKHG3_HUMAN	pleckstrin homology domain containing, family G,	458				QGRRQSEPTKHLLRQLNEKARAAGMK -> KGAGPEPPGSE EEEEEQEESLAVAEQ (in Ref. 2; AAH04298).	regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(1)	1				all cancers(60;0.00802)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)|BRCA - Breast invasive adenocarcinoma(234;0.0485)		TCAGGCAACTCAACGAGAAAG	0.617		NaN											0	0	0	0.002836	0	27	84				
FUT8	2530	broad.mit.edu	37	14	66028339	66028339	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr14:66028339A>C	uc001xin.2	+	3	1255	c.58A>C	c.(58-60)ACC>CCC	p.T20P	FUT8_uc001xio.2_Missense_Mutation_p.T20P|FUT8_uc010tsp.1_Intron|FUT8_uc001xir.3_RNA|FUT8_uc001xip.2_Missense_Mutation_p.T20P|FUT8_uc001xiq.2_Intron	NM_178155	NP_835368	Q9BYC5	FUT8_HUMAN	fucosyltransferase 8 isoform a	20	Helical; Signal-anchor for type II membrane protein; (Potential).				in utero embryonic development|L-fucose catabolic process|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in Golgi|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	glycoprotein 6-alpha-L-fucosyltransferase activity|SH3 domain binding			ovary(1)	1				all cancers(60;0.00109)|OV - Ovarian serous cystadenocarcinoma(108;0.00242)|BRCA - Breast invasive adenocarcinoma(234;0.0114)		TGCCTGGGGGACCTTGCTGTT	0.473		NaN											0	0	0	0.00361	0	70	52				
ZFYVE26	23503	broad.mit.edu	37	14	68233024	68233024	+	Silent	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr14:68233024G>A	uc001xka.2	-	32	6070	c.5931C>T	c.(5929-5931)GAC>GAT	p.D1977D	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Silent_p.D1977D	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	1977					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		GCTTCATGATGTCCGTGAGCA	0.587		NaN											0	0	0	0.00361	0	45	128				
HEATR4	399671	broad.mit.edu	37	14	73964942	73964942	+	Silent	SNP	G	G	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr14:73964942G>T	uc010tub.1	-	14	2785	c.2463C>A	c.(2461-2463)ATC>ATA	p.I821I	HEATR4_uc010tua.1_Silent_p.I774I	NM_203309	NP_976054			HEAT repeat containing 4											ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00386)|OV - Ovarian serous cystadenocarcinoma(108;0.0719)		TCAGGGCTAGGATGCTACGGC	0.537		NaN											1	0	4.65686e-17	0.003755	5.10945e-17	29	22				
ATXN3	4287	broad.mit.edu	37	14	92555135	92555135	+	Silent	SNP	C	C	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr14:92555135C>G	uc001yac.3	-	6	483	c.414G>C	c.(412-414)ACG>ACC	p.T138T	ATXN3_uc010aug.2_Silent_p.T123T|ATXN3_uc001yad.3_Silent_p.T83T|ATXN3_uc010auh.2_Silent_p.T72T|ATXN3_uc001yae.3_Silent_p.T40T|ATXN3_uc010twl.1_RNA	NM_004993	NP_004984	P54252	ATX3_HUMAN	ataxin 3 reference isoform	138	Josephin.				cell death|nervous system development|nucleotide-excision repair|regulation of transcription, DNA-dependent|synaptic transmission|transcription, DNA-dependent	cytoplasm|nuclear matrix|nucleoplasm	cysteine-type peptidase activity|protein binding				0		all_cancers(154;0.0768)		COAD - Colon adenocarcinoma(157;0.224)		ATTCTGGACCCGTCAAGAGAG	0.318		NaN											0	0	0	0.00361	0	59	43				
BCL11B	64919	broad.mit.edu	37	14	99723962	99723962	+	Silent	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr14:99723962C>T	uc001yga.2	-	2	540	c.273G>A	c.(271-273)AAG>AAA	p.K91K	BCL11B_uc001ygb.2_Silent_p.K91K	NM_138576	NP_612808	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B isoform 1	91						nucleus	zinc ion binding			central_nervous_system(8)|large_intestine(1)|lung(1)	10		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		TGTCCAGGGCCTTGTCATAGC	0.587		NaN	T	TLX3	T-ALL								0	0	0	0.00361	0	131	84				
RTL1	388015	broad.mit.edu	37	14	101351019	101351019	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr14:101351019G>A	uc010txj.1	-	1	166	c.107C>T	c.(106-108)ACG>ATG	p.T36M	uc010txk.1_5'Flank|MIR136_hsa-mir-136|MI0000475_5'Flank	NM_001134888	NP_001128360	A6NKG5	RTL1_HUMAN	retrotransposon-like 1	36										pancreas(1)	1						ACTGCCCGACGTCGCCTCGGT	0.587		NaN											0	0	0	0.00499	0	12	41				
HSP90AA1	3320	broad.mit.edu	37	14	102605682	102605682	+	Silent	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr14:102605682C>T	uc001ykv.3	-	1	405	c.60G>A	c.(58-60)AGG>AGA	p.R20R	WDR20_uc001yky.1_5'Flank|WDR20_uc001yla.2_5'Flank|WDR20_uc001ykz.2_5'Flank|WDR20_uc001ylb.2_5'Flank|WDR20_uc010txu.1_5'Flank|WDR20_uc001ylc.2_5'Flank|WDR20_uc001yld.2_5'Flank|WDR20_uc001yle.2_5'Flank|WDR20_uc001ylf.2_5'Flank	NM_001017963	NP_001017963	P07900	HS90A_HUMAN	heat shock 90kDa protein 1, alpha isoform 1	Error:Variant_position_missing_in_P07900_after_alignment					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			ovary(2)|central_nervous_system(2)|prostate(1)|lung(1)|breast(1)	7					Rifabutin(DB00615)	CGGGACAGTCCCTGTCCCGAA	0.706		NaN											0	0	0	0.00333	0	24	11				
FMN1	342184	broad.mit.edu	37	15	33360066	33360066	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr15:33360066G>A	uc001zhf.3	-	1	20	c.20C>T	c.(19-21)TCT>TTT	p.S7F	FMN1_uc001zhg.2_Missense_Mutation_p.S7F	NM_001103184	NP_001096654	Q68DA7	FMN1_HUMAN	formin 1	Error:Variant_position_missing_in_Q68DA7_after_alignment					actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		GCCATCCAGAGAATTATCAAC	0.468		NaN											0	0	0	0.008291	0	8	26				
ACTC1	70	broad.mit.edu	37	15	35084467	35084467	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr15:35084467A>G	uc001ziu.1	-	5	875	c.632T>C	c.(631-633)GTC>GCC	p.V211A	uc001zit.1_Intron	NM_005159	NP_005150	P68032	ACTC_HUMAN	cardiac muscle alpha actin 1 proprotein	211					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		AATGTCACGGACAATTTCACG	0.468		NaN											0	0	0	0.001855	0	12	8				
MYO5C	55930	broad.mit.edu	37	15	52534274	52534274	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr15:52534274C>A	uc010bff.2	-	20	2664	c.2527G>T	c.(2527-2529)GGA>TGA	p.G843*	MYO5C_uc010uga.1_Intron|MYO5C_uc010ugb.1_Intron	NM_018728	NP_061198	Q9NQX4	MYO5C_HUMAN	myosin VC	843	IQ 4.					myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(7)|central_nervous_system(3)|large_intestine(2)|skin(2)	14				all cancers(107;0.0137)		GCCAGGAATCCTCGGCTGTAG	0.547		NaN											1	0	1.44639e-49	0.00361	1.67251e-49	93	100				
PIGB	9488	broad.mit.edu	37	15	55632964	55632964	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr15:55632964C>T	uc002act.2	+	8	1317	c.1001C>T	c.(1000-1002)GCA>GTA	p.A334V	PIGB_uc010ugg.1_Missense_Mutation_p.A139V	NM_004855	NP_004846	Q92521	PIGB_HUMAN	phosphatidylinositol glycan, class B	334	Helical; (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	integral to membrane|intrinsic to endoplasmic reticulum membrane	glycolipid mannosyltransferase activity				0				all cancers(107;0.0255)		TGCTATCTAGCACCAAAGAGA	0.378		NaN											0	0	0	0.000602	0	4	5				
MYO1E	4643	broad.mit.edu	37	15	59548521	59548521	+	Silent	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr15:59548521G>A	uc002aga.2	-	4	666	c.294C>T	c.(292-294)AAC>AAT	p.N98N		NM_004998	NP_004989	Q12965	MYO1E_HUMAN	myosin IE	98	Myosin head-like.				actin filament-based movement	myosin complex	actin binding|ATP binding|ATPase activity, coupled|calmodulin binding|microfilament motor activity			central_nervous_system(3)	3				all cancers(107;0.207)		CAATGATCATGTTTCTGTACA	0.343		NaN											0	0	0	0.001855	0	10	26				
PPCDC	60490	broad.mit.edu	37	15	75336745	75336745	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr15:75336745G>A	uc002azo.2	+	4	363	c.250G>A	c.(250-252)GAC>AAC	p.D84N		NM_021823	NP_068595	Q96CD2	COAC_HUMAN	phosphopantothenoylcysteine decarboxylase	84					coenzyme A biosynthetic process|pantothenate metabolic process	cytosol	phosphopantothenoylcysteine decarboxylase activity				0						GAGCCGCTCTGACCCAGTTCT	0.587		NaN											0	0	0	0.00361	0	44	36				
MTHFS	10588	broad.mit.edu	37	15	80137594	80137594	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr15:80137594C>A	uc002bex.3	-	3	610	c.570G>T	c.(568-570)ATG>ATT	p.M190I	MTHFS_uc002bey.2_RNA	NM_006441	NP_006432	P49914	MTHFS_HUMAN	5,10-methenyltetrahydrofolate synthetase	190					folic acid-containing compound biosynthetic process|formate metabolic process|tetrahydrofolate metabolic process	cytosol|Golgi apparatus|plasma membrane	5-formyltetrahydrofolate cyclo-ligase activity|ATP binding|folic acid binding				0				all cancers(203;0.00467)		CATCTACCTTCATGTCGTTTT	0.428		NaN											1	0	1.33987e-11	0.008291	1.44061e-11	9	50				
ARNT2	9915	broad.mit.edu	37	15	80872758	80872758	+	Silent	SNP	A	A	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr15:80872758A>G	uc002bfr.2	+	16	1786	c.1620A>G	c.(1618-1620)TCA>TCG	p.S540S	ARNT2_uc010unm.1_Silent_p.S529S|ARNT2_uc002bfs.2_Silent_p.S529S	NM_014862	NP_055677	Q9HBZ2	ARNT2_HUMAN	aryl hydrocarbon receptor nuclear translocator	540					central nervous system development|in utero embryonic development|response to hypoxia		aryl hydrocarbon receptor binding|DNA binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|signal transducer activity			central_nervous_system(3)|ovary(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.134)			CTAGCTCTTCAGTGGTTCATG	0.512		NaN											0	0	0	0.00632	0	23	92				
SV2B	9899	broad.mit.edu	37	15	91769791	91769791	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr15:91769791G>T	uc002bqv.2	+	1	689	c.298G>T	c.(298-300)GAT>TAT	p.D100Y	SV2B_uc002bqt.2_Missense_Mutation_p.D100Y|SV2B_uc010uqv.1_Intron|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	100	Cytoplasmic (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			GACCATCATGGATGAGTGTGG	0.587		NaN											1	0	4.36969e-10	0.001855	4.61723e-10	14	33				
IL32	9235	broad.mit.edu	37	16	3119252	3119252	+	Silent	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:3119252C>T	uc002cto.2	+	6	812	c.601C>T	c.(601-603)CTG>TTG	p.L201L	IL32_uc002ctk.2_Intron|IL32_uc010uwp.1_Silent_p.L135L|IL32_uc010btb.2_Silent_p.L145L|IL32_uc002ctl.2_Silent_p.L155L|IL32_uc002ctm.2_Silent_p.L155L|IL32_uc002ctn.2_Silent_p.L155L|IL32_uc002cts.3_Silent_p.L155L|IL32_uc002ctp.2_Silent_p.L135L|IL32_uc002ctq.2_Silent_p.L201L|IL32_uc002ctr.2_Silent_p.L135L|IL32_uc002ctt.2_Silent_p.L155L|IL32_uc010uwr.1_Silent_p.L115L|IL32_uc002ctu.2_Silent_p.L146L	NM_004221	NP_004212	P24001	IL32_HUMAN	interleukin 32 isoform B	201					cell adhesion|defense response|immune response	extracellular space	cytokine activity			pancreas(1)	1						CTGCTGCTCTCTGTCAGAGCT	0.592		NaN											0	0	0	0.000978	0	11	62				
CREBBP	1387	broad.mit.edu	37	16	3900861	3900861	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:3900861C>T	uc002cvv.2	-	2	439	c.235G>A	c.(235-237)GGC>AGC	p.G79S	CREBBP_uc002cvw.2_Missense_Mutation_p.G79S	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	79					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		ATACTAGAGCCGCTGCCTCCT	0.542		NaN	T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				0	0	0	0.002299	0	21	62		Valid		
MYH11	4629	broad.mit.edu	37	16	15818266	15818266	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:15818266G>C	uc002ddy.2	-	31	4224	c.4117C>G	c.(4117-4119)CTC>GTC	p.L1373V	MYH11_uc002ddv.2_Missense_Mutation_p.L1380V|MYH11_uc002ddw.2_Missense_Mutation_p.L1373V|MYH11_uc002ddx.2_Missense_Mutation_p.L1380V|MYH11_uc010bvg.2_Missense_Mutation_p.L1205V|NDE1_uc010uzy.1_3'UTR|NDE1_uc002dds.2_3'UTR|MYH11_uc010bvh.2_Missense_Mutation_p.L79V|NDE1_uc002ddz.1_RNA	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	1373	Potential.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						GAGTCGGAGAGCTACAAGGAC	0.582		NaN	T	CBFB	AML								0	0	0	0.004007	0	14	45				
RPGRIP1L	23322	broad.mit.edu	37	16	53698905	53698905	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:53698905G>C	uc002ehp.2	-	10	1184	c.1120C>G	c.(1120-1122)CAT>GAT	p.H374D	RPGRIP1L_uc002eho.3_Missense_Mutation_p.H374D|RPGRIP1L_uc010vgy.1_Missense_Mutation_p.H374D|RPGRIP1L_uc010cbx.2_Missense_Mutation_p.H374D|RPGRIP1L_uc010vgz.1_Missense_Mutation_p.H374D	NM_015272	NP_056087	Q68CZ1	FTM_HUMAN	RPGRIP1-like isoform a	374	Potential.				negative regulation of G-protein coupled receptor protein signaling pathway	cell-cell junction|centrosome|cilium axoneme|microtubule basal body	thromboxane A2 receptor binding			ovary(1)	1		all_cancers(37;0.0973)				TGCTCTTCATGGGCAGCACTG	0.438		NaN											0	0	0	0.006122	0	15	17				
GPR56	9289	broad.mit.edu	37	16	57685350	57685350	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:57685350A>T	uc002emb.2	+	4	595	c.303A>T	c.(301-303)TTA>TTT	p.L101F	GPR56_uc002elz.1_Intron|GPR56_uc002ema.1_5'UTR|GPR56_uc002emc.2_Missense_Mutation_p.L101F|GPR56_uc002emf.2_Missense_Mutation_p.L101F|GPR56_uc010vhs.1_Missense_Mutation_p.L101F|GPR56_uc002emd.2_Missense_Mutation_p.L101F|GPR56_uc002eme.2_Missense_Mutation_p.L101F|GPR56_uc010vht.1_Missense_Mutation_p.L106F|GPR56_uc002emg.3_Missense_Mutation_p.L101F|GPR56_uc010vhu.1_5'UTR	NM_005682	NP_005673	Q9Y653	GPR56_HUMAN	G protein-coupled receptor 56 isoform a	101	Extracellular (Potential).				brain development|cell adhesion|cell-cell signaling|neuropeptide signaling pathway	integral to plasma membrane	G-protein coupled receptor activity				0						CTGGGAGATTACATCTTCTCT	0.602		NaN											0	0	0	0.007413	0	19	60				
GPR97	222487	broad.mit.edu	37	16	57719645	57719645	+	Silent	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:57719645C>T	uc002emh.2	+	11	1450	c.1347C>T	c.(1345-1347)GTC>GTT	p.V449V	GPR97_uc010vhv.1_Silent_p.V329V|GPR97_uc010cdd.2_RNA|GPR97_uc010cde.2_Silent_p.V57V	NM_170776	NP_740746	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97 precursor	449	Helical; Name=5; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1						GCATGGTGGTCCTGGCCCTGG	0.592		NaN											0	0	0	0.010504	0	21	80				
KATNB1	10300	broad.mit.edu	37	16	57786831	57786831	+	Silent	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:57786831T>C	uc002eml.1	+	10	1220	c.846T>C	c.(844-846)AAT>AAC	p.N282N		NM_005886	NP_005877	Q9BVA0	KTNB1_HUMAN	katanin p80 subunit B 1	282	Interaction with centrosomes.|Interaction with dynein (By similarity).				cell division|mitosis|negative regulation of microtubule depolymerization|positive regulation of microtubule depolymerization|protein targeting	katanin complex|microtubule|spindle pole	microtubule binding|protein heterodimerization activity				0		all_neural(199;0.223)				CCATCTGCAATGACCAGTTGG	0.667		NaN											0	0	0	0.007291	0	21	58				
NDRG4	65009	broad.mit.edu	37	16	58538110	58538110	+	Silent	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:58538110C>T	uc002eno.2	+	3	286	c.180C>T	c.(178-180)ACC>ACT	p.T60T	NDRG4_uc002enk.2_Silent_p.T92T|NDRG4_uc002enm.2_Silent_p.T112T|NDRG4_uc010vif.1_Silent_p.T92T|NDRG4_uc010cdk.2_Silent_p.T78T|NDRG4_uc010vig.1_Silent_p.T90T|NDRG4_uc010vih.1_Silent_p.T5T|NDRG4_uc010vii.1_Silent_p.T78T|NDRG4_uc002enp.2_Silent_p.T60T|NDRG4_uc002enq.1_5'Flank	NM_022910	NP_075061	Q9ULP0	NDRG4_HUMAN	NDRG family member 4 isoform 1	60					cell differentiation|cell growth|multicellular organismal development|response to stress	cytoplasm				skin(1)	1						AGGAGATCACCAAGCACTTTG	0.572		NaN											0	0	0	0.00874	0	39	179				
CBFB	865	broad.mit.edu	37	16	67116228	67116228	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:67116228T>A	uc002era.2	+	5	773	c.512T>A	c.(511-513)CTG>CAG	p.L171Q	CBFB_uc002erb.2_Intron|CBFB_uc010vja.1_Intron	NM_001755	NP_001746	Q13951	PEBB_HUMAN	core-binding factor, beta subunit isoform 2	171					transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			breast(2)	2		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00189)|Epithelial(162;0.00755)|all cancers(182;0.066)		GTTTCACAGCTGCTGGCAGTA	0.428		NaN	T	MYH11	AML								0	0	0	0.00361	0	38	83				
THAP11	57215	broad.mit.edu	37	16	67876805	67876805	+	Silent	SNP	A	A	G	rs28434205	byFrequency	TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:67876805A>G	uc002euo.2	+	1	593	c.348A>G	c.(346-348)CAA>CAG	p.Q116Q	CENPT_uc002eun.3_Intron	NM_020457	NP_065190	Q96EK4	THA11_HUMAN	THAP domain containing 11	116	Gln-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|identical protein binding|metal ion binding				0		Acute lymphoblastic leukemia(13;0.000299)|all_hematologic(13;0.0184)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00412)|Epithelial(162;0.018)|all cancers(182;0.118)		aacagcagcaacagcagcagc	0.303		NaN											0	0	0	0.010504	0	20	128				
VPS4A	27183	broad.mit.edu	37	16	69352762	69352762	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:69352762A>G	uc002eww.2	+	5	508	c.380A>G	c.(379-381)AAC>AGC	p.N127S		NM_013245	NP_037377	Q9UN37	VPS4A_HUMAN	vacuolar protein sorting factor 4A	127					cell cycle|cellular membrane organization|cytokinesis|endosome transport|protein transport	cytosol|late endosome membrane|midbody|perinuclear region of cytoplasm	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein domain specific binding				0		Ovarian(137;0.101)				ATACGGTGGAACGACGTGGCC	0.507		NaN											0	0	0	0.00361	0	72	239				
ZNF23	7571	broad.mit.edu	37	16	71483261	71483261	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:71483261G>A	uc002faf.2	-	6	1481	c.667C>T	c.(667-669)CCC>TCC	p.P223S	ZNF23_uc002fad.2_Missense_Mutation_p.P165S|ZNF23_uc002fae.2_Missense_Mutation_p.P165S|ZNF23_uc010vmf.1_Missense_Mutation_p.P165S|ZNF23_uc002fag.2_Missense_Mutation_p.P165S|ZNF23_uc002fah.2_Missense_Mutation_p.P223S|ZNF23_uc002fai.2_Missense_Mutation_p.P262S	NM_145911	NP_666016	P17027	ZNF23_HUMAN	zinc finger protein 23	223					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(137;0.00768)		BRCA - Breast invasive adenocarcinoma(221;0.0686)		CATTTGAAGGGTTTCTCCCCA	0.438		NaN											0	0	0	0.00361	0	40	32				
CHST4	10164	broad.mit.edu	37	16	71571354	71571354	+	Silent	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:71571354G>A	uc002fan.2	+	2	955	c.774G>A	c.(772-774)AAG>AAA	p.K258K	CHST4_uc002fao.2_Silent_p.K258K	NM_005769	NP_005760	Q8NCG5	CHST4_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	258	Lumenal (Potential).				cell-cell signaling|immune response|inflammatory response|N-acetylglucosamine metabolic process|protein sulfation	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity				0						AGATCTACAAGACCATCCAGT	0.557		NaN									OREG0023923	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000978	0	9	63				
PHLPP2	23035	broad.mit.edu	37	16	71706188	71706188	+	Silent	SNP	C	C	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:71706188C>A	uc002fax.2	-	9	1515	c.1509G>T	c.(1507-1509)CTG>CTT	p.L503L	PHLPP2_uc002fav.2_RNA|PHLPP2_uc010cgf.2_Silent_p.L503L	NM_015020	NP_055835	Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein	503	LRR 12.					cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)|central_nervous_system(1)	2						AGAAAGTGAGCAGGCTGGGTA	0.438		NaN											1	0	2.48551e-13	0.00499	2.69945e-13	11	26				
ASPA	443	broad.mit.edu	37	17	3379514	3379514	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:3379514C>G	uc010ckg.2	+	2	152	c.61C>G	c.(61-63)CAT>GAT	p.H21D	SPATA22_uc010vrg.1_Intron|ASPA_uc002fvq.2_Missense_Mutation_p.H21D	NM_001128085	NP_001121557	P45381	ACY2_HUMAN	aspartoacylase	21		Zinc.	H -> P (in CAND).		aspartate catabolic process	cytoplasm|nucleus	aminoacylase activity|aspartoacylase activity|hydrolase activity, acting on ester bonds|metal ion binding				0					L-Aspartic Acid(DB00128)	TGGAGGAACCCATGGGAATGA	0.398		NaN											0	0	0	0.00874	0	34	29				
TP53	7157	broad.mit.edu	37	17	7578208	7578208	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08			T	C	T	T		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:7578208T>C	uc002gim.2	-	6	835	c.641A>G	c.(640-642)CAT>CGT	p.H214R	TP53_uc002gig.1_Missense_Mutation_p.H214R|TP53_uc002gih.2_Missense_Mutation_p.H214R|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.H82R|TP53_uc010cng.1_Missense_Mutation_p.H82R|TP53_uc002gii.1_Missense_Mutation_p.H82R|TP53_uc010cnh.1_Missense_Mutation_p.H214R|TP53_uc010cni.1_Missense_Mutation_p.H214R|TP53_uc002gij.2_Missense_Mutation_p.H214R|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Missense_Mutation_p.H121R|TP53_uc002gio.2_Missense_Mutation_p.H82R|TP53_uc010vug.1_Missense_Mutation_p.H175R	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	214	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		H -> Y (in sporadic cancers; somatic mutation).|H -> D (in sporadic cancers; somatic mutation).|H -> R (in sporadic cancers; somatic mutation).|H -> Q (in sporadic cancers; somatic mutation).|H -> P (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H214R(45)|p.0?(7)|p.H214Y(4)|p.H214Q(4)|p.H214D(3)|p.H214fs*5(2)|p.H214fs*33(2)|p.D208fs*1(1)|p.K164_P219del(1)|p.H214H(1)|p.H214fs*7(1)|p.T211fs*28(1)|p.R213_S215>X(1)|p.D207_V216del10(1)|p.R213fs*32(1)|p.T211_S215delTFRHS(1)|p.H214_S215insX(1)|p.R209fs*6(1)|p.D208_V216delDRNTFRHSV(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CACCACACTATGTCGAAAAGT	0.542		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.00361	0	42	13		Valid		
CHD3	1107	broad.mit.edu	37	17	7788214	7788214	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:7788214G>C	uc002gjd.2	+	1	92	c.90G>C	c.(88-90)GAG>GAC	p.E30D		NM_001005271	NP_001005271	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	445	Poly-Glu.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(1)	1		Prostate(122;0.202)				agggcgacgaggaggaggagg	0.299		NaN											0	0	0	0.004672	0	2	3				
TOP2A	7153	broad.mit.edu	37	17	38556598	38556598	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:38556598T>C	uc002huq.2	-	23	2989	c.2863A>G	c.(2863-2865)ACA>GCA	p.T955A		NM_001067	NP_001058	P11388	TOP2A_HUMAN	DNA topoisomerase II, alpha isozyme	955					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	CTATAGTCTGTTATGAGAGGA	0.378		NaN											0	0	0	0.001855	0	11	15				
KRT16	3868	broad.mit.edu	37	17	39766722	39766722	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:39766722T>C	uc002hxg.3	-	6	1280	c.1141A>G	c.(1141-1143)AGT>GGT	p.S381G	JUP_uc010wfs.1_Intron	NM_005557	NP_005548	P08779	K1C16_HUMAN	keratin 16	381	Rod.|Coil 2.				cell proliferation|epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton			skin(1)	1		Breast(137;0.000307)				TCCTCCACACTGCCAATCAGT	0.577		NaN											0	0	0	0.00361	0	59	126				
JUP	3728	broad.mit.edu	37	17	39923802	39923802	+	Silent	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:39923802G>A	uc002hxq.2	-	5	1015	c.738C>T	c.(736-738)GCC>GCT	p.A246A	JUP_uc010wfs.1_Silent_p.A246A|JUP_uc002hxr.2_Silent_p.A246A|JUP_uc002hxs.2_Silent_p.A246A	NM_021991	NP_068831	P14923	PLAK_HUMAN	junction plakoglobin	246	ARM 2.				adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			ovary(2)|lung(2)|breast(1)	5		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		GCGTGGTGATGGCATAGAACA	0.637		NaN											0	0	0	0.00333	0	24	85				
DHX8	1659	broad.mit.edu	37	17	41598153	41598153	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:41598153A>G	uc002idu.1	+	20	3045	c.2972A>G	c.(2971-2973)AAA>AGA	p.K991R	DHX8_uc010wig.1_Missense_Mutation_p.K991R	NM_004941	NP_004932	Q14562	DHX8_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 8	991						catalytic step 2 spliceosome	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(2)|kidney(1)|pancreas(1)	4		Breast(137;0.00908)		BRCA - Breast invasive adenocarcinoma(366;0.08)		ATGCTATGCAAAATGCTCATC	0.478		NaN									OREG0024435	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010504	0	19	14				
ITGA2B	3674	broad.mit.edu	37	17	42455070	42455071	+	Missense_Mutation	DNP	GC	GC	TA	rs146445219		TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:42455070_42455071GC>TA	uc002igt.1	-	21	2214_2215	c.2182_2183GC>TA	c.(2182-2184)GCC>TAC	p.A728Y	ITGA2B_uc002igu.1_Missense_Mutation_p.A209Y	NM_000419	NP_000410	P08514	ITA2B_HUMAN	integrin alpha 2b preproprotein	728	Extracellular (Potential).				axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	CCTCACCTGGGCGTTCTTCTTC	0.47		NaN											0	0	0	0.004672	0	12	49				
AKAP1	8165	broad.mit.edu	37	17	55195741	55195741	+	Splice_Site	SNP	G	G	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:55195741G>T	uc002iux.2	+	9	2732	c.2501_splice	c.e9-1	p.D834_splice	AKAP1_uc010wnl.1_Splice_Site_p.D834_splice|AKAP1_uc010dcm.2_Splice_Site_p.D834_splice	NM_003488	NP_003479	Q92667	AKAP1_HUMAN	A-kinase anchor protein 1 precursor						blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			ovary(1)	1	Breast(9;5.46e-08)					TCCTCCTGAAGACGATGACCA	0.532		NaN											1	0	5.71845e-15	0.005524	6.2582e-15	32	37				
LPO	4025	broad.mit.edu	37	17	56327935	56327935	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:56327935C>G	uc002ivt.2	+	7	1049	c.733C>G	c.(733-735)CAG>GAG	p.Q245E	LPO_uc010dco.2_Missense_Mutation_p.Q245E|LPO_uc010wnr.1_Missense_Mutation_p.Q162E|LPO_uc010wns.1_Missense_Mutation_p.Q186E|LPO_uc010dcp.2_Missense_Mutation_p.Q162E|LPO_uc010dcq.2_Intron|LPO_uc010dcr.2_5'Flank	NM_006151	NP_006142	P22079	PERL_HUMAN	lactoperoxidase isoform 1 preproprotein	245					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|breast(1)	2						CTCCAAAGCCCAGTGTGATGA	0.557		NaN											0	0	0	0.002522	0	37	27				
RAD51C	5889	broad.mit.edu	37	17	56780655	56780655	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:56780655T>C	uc002iwu.2	+	4	712	c.670T>C	c.(670-672)TAT>CAT	p.Y224H	RAD51C_uc010woa.1_Missense_Mutation_p.Y224H|RAD51C_uc010ddc.2_RNA|RAD51C_uc002iwv.2_RNA|RAD51C_uc002iww.2_RNA|RAD51C_uc010wob.1_RNA	NM_058216	NP_478123	O43502	RA51C_HUMAN	RAD51 homolog C isoform 1	224					blood coagulation|DNA repair	mitochondrion|nucleoplasm|perinuclear region of cytoplasm	ATP binding|DNA binding|DNA-dependent ATPase activity				0	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GGCACAAGTTTATCTTCTTCC	0.348		NaN						Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2				0	0	0	0.001368	0	10	27				
RNFT1	51136	broad.mit.edu	37	17	58040588	58040588	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:58040588C>T	uc002iya.2	-	2	207	c.114G>A	c.(112-114)ATG>ATA	p.M38I	uc002iye.1_5'Flank|RNFT1_uc002iyb.2_RNA|RNFT1_uc002iyc.2_5'UTR|RNFT1_uc010wop.1_Missense_Mutation_p.M38I|RNFT1_uc002iyd.3_Missense_Mutation_p.M38I	NM_016125	NP_057209	Q5M7Z0	RNFT1_HUMAN	PTD016 protein	38						integral to membrane	zinc ion binding				0	all_cancers(5;1.58e-13)|Breast(5;2.91e-25)|all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;7.95e-12)|all cancers(12;1.34e-10)			GATTGGCTTGCATGGCCCTTA	0.453		NaN											0	0	0	0.001368	0	11	40				
SCN4A	6329	broad.mit.edu	37	17	62021113	62021113	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:62021113C>T	uc002jds.1	-	22	4087	c.4010G>A	c.(4009-4011)CGG>CAG	p.R1337Q		NM_000334	NP_000325	P35499	SCN4A_HUMAN	voltage-gated sodium channel type 4 alpha	1337					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(1)|pancreas(1)|skin(1)	3					Lamotrigine(DB00555)	TACCTGGGGCCGGGGAATTGG	0.353		NaN											0	0	0	0.001168	0	4	13				
DDX5	1655	broad.mit.edu	37	17	62499626	62499626	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:62499626A>C	uc002jek.2	-	6	818	c.571T>G	c.(571-573)TGT>GGT	p.C191G	DDX5_uc010deh.2_Missense_Mutation_p.C191G|DDX5_uc002jej.2_Missense_Mutation_p.C86G|DDX5_uc010wqa.1_Missense_Mutation_p.C112G|DDX5_uc002jel.1_5'Flank	NM_004396	NP_004387	P17844	DDX5_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 5	191	Helicase ATP-binding.				cell growth|regulation of alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|mRNA binding|protein binding|RNA helicase activity|transcription cofactor activity			ovary(2)|lung(1)	3	Breast(5;2.15e-14)		BRCA - Breast invasive adenocarcinoma(8;8.6e-12)			CATGCTCTACAATATTCAGCA	0.463		NaN	T	ETV4	prostate								0	0	0	0.00278	0	18	45				
PSMD12	5718	broad.mit.edu	37	17	65337149	65337149	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:65337149G>A	uc002jfy.2	-	11	1267	c.1181C>T	c.(1180-1182)TCA>TTA	p.S394L	PSMD12_uc002jga.2_Missense_Mutation_p.S374L|PSMD12_uc002jfz.2_Missense_Mutation_p.S335L	NM_002816	NP_002807	O00232	PSD12_HUMAN	proteasome 26S non-ATPase subunit 12 isoform 1	394	PCI.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome regulatory particle	protein binding				0	all_cancers(12;2.38e-11)|all_epithelial(3;8.27e-13)					TACTAGATTTGAGAGAAAGGC	0.338		NaN											0	0	0	0.006214	0	7	18				
KCTD2	23510	broad.mit.edu	37	17	73043506	73043506	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:73043506C>T	uc002jmp.2	+	1	228	c.161C>T	c.(160-162)CCG>CTG	p.P54L	KCTD2_uc010dfy.1_Intron|KCTD2_uc010dfz.2_Intron|ATP5H_uc002jmn.1_5'Flank|ATP5H_uc002jmo.1_5'Flank|KCTD2_uc002jmq.2_Intron	NM_015353	NP_056168	Q14681	KCTD2_HUMAN	potassium channel tetramerisation domain	54				P -> R (in Ref. 1; BAA11493).		voltage-gated potassium channel complex	voltage-gated potassium channel activity				0	all_lung(278;0.226)					gtcgcgcagccgctggagccg	0.149		NaN											0	0	0	0.00308	0	8	5				
LLGL2	3993	broad.mit.edu	37	17	73569202	73569202	+	Silent	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:73569202C>T	uc002joh.2	+	20	2722	c.2568C>T	c.(2566-2568)GCC>GCT	p.A856A	LLGL2_uc002joi.2_Silent_p.A856A|LLGL2_uc010dgg.1_Silent_p.A856A|LLGL2_uc002joj.2_Silent_p.A845A|LLGL2_uc010wsd.1_Silent_p.A483A	NM_001031803	NP_001026973	Q6P1M3	L2GL2_HUMAN	lethal giant larvae homolog 2 isoform c	856	WD 13.				cell cycle|cell division|exocytosis|regulation of establishment or maintenance of cell polarity	cytoplasm|intracellular membrane-bounded organelle	PDZ domain binding			ovary(2)	2	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;1.8e-07)|Epithelial(20;1.38e-06)|Lung(188;0.0696)|LUSC - Lung squamous cell carcinoma(166;0.112)			GTCGTCGAGCCGAGGACTACG	0.657		NaN											0	0	0	0.00361	0	64	82				
QRICH2	84074	broad.mit.edu	37	17	74283886	74283886	+	Silent	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:74283886G>A	uc002jrd.1	-	6	3573	c.3393C>T	c.(3391-3393)GTC>GTT	p.V1131V	QRICH2_uc010wsz.1_Silent_p.V1057V|QRICH2_uc010dgw.1_5'UTR	NM_032134	NP_115510	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1131	Potential.						protein binding			ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)|skin(1)	5						TTTACCTGAGGACACCCAGCT	0.557		NaN											0	0	0	0.00245	0	12	49				
MFSD11	79157	broad.mit.edu	37	17	74737129	74737129	+	Silent	SNP	C	C	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:74737129C>G	uc002jta.2	+	4	1216	c.243C>G	c.(241-243)GCC>GCG	p.A81A	MFSD11_uc002jtb.2_Silent_p.A81A|MFSD11_uc010dha.2_Silent_p.A81A|MFSD11_uc002jtc.2_Silent_p.A81A|MFSD11_uc002jtd.3_Silent_p.A81A|MFSD11_uc010dhb.2_Silent_p.A81A|MFSD11_uc002jte.2_Silent_p.A81A	NM_024311	NP_077287	O43934	MFS11_HUMAN	major facilitator superfamily domain containing	81	Helical; (Potential).					integral to membrane				ovary(1)	1						CTATGTTTGCCAGTGGTTTAT	0.363		NaN											0	0	0	0.005443	0	26	41				
NPLOC4	55666	broad.mit.edu	37	17	79580442	79580442	+	Silent	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr17:79580442G>A	uc002kat.3	-	4	470	c.288C>T	c.(286-288)GGC>GGT	p.G96G	NPLOC4_uc002kau.3_Silent_p.G96G|NPLOC4_uc010wur.1_5'UTR	NM_017921	NP_060391	Q8TAT6	NPL4_HUMAN	nuclear protein localization 4	96					cellular membrane fusion|ER-associated protein catabolic process|Golgi organization	cytosol|endoplasmic reticulum|nuclear outer membrane-endoplasmic reticulum membrane network|nucleus	zinc ion binding			ovary(1)|central_nervous_system(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			AGACTTTGAAGCCCGGTGGAA	0.517		NaN											0	0	0	0.004672	0	3	26				
RBBP8	5932	broad.mit.edu	37	18	20581688	20581688	+	Silent	SNP	A	A	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr18:20581688A>G	uc002ktw.2	+	15	2614	c.2283A>G	c.(2281-2283)CTA>CTG	p.L761L	RBBP8_uc002kty.2_Silent_p.L761L|RBBP8_uc002ktz.2_Silent_p.L761L|RBBP8_uc002kua.2_Silent_p.L766L|RBBP8_uc010xap.1_Silent_p.L99L	NM_002894	NP_002885	Q99708	COM1_HUMAN	retinoblastoma binding protein 8 isoform a	761					cell cycle checkpoint|DNA double-strand break processing involved in repair via single-strand annealing|meiosis|regulation of transcription from RNA polymerase II promoter	nucleus	damaged DNA binding|protein binding|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)|lung(1)|skin(1)	3	all_cancers(21;4.34e-05)|all_epithelial(16;8.3e-07)|Lung NSC(20;0.0107)|Colorectal(14;0.0202)|all_lung(20;0.0291)|Ovarian(20;0.19)		OV - Ovarian serous cystadenocarcinoma(1;0.00196)			CAAAGAAACTACACAGTAAGA	0.373		NaN						Direct_reversal_of_damage|Homologous_recombination					0	0	0	0.00308	0	8	16				
LAMA3	3909	broad.mit.edu	37	18	21485588	21485588	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr18:21485588G>T	uc002kuq.2	+	52	6804	c.6718G>T	c.(6718-6720)GAA>TAA	p.E2240*	LAMA3_uc002kur.2_Nonsense_Mutation_p.E2184*|LAMA3_uc002kus.3_Nonsense_Mutation_p.E631*|LAMA3_uc002kut.3_Nonsense_Mutation_p.E575*	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	2240	Domain II and I.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GCTAAAGCAAGGTATTAGGGG	0.438		NaN											1	0	0.00909568	0.009096	0.00924656	3	19				
CDH2	1000	broad.mit.edu	37	18	25532201	25532201	+	Silent	SNP	A	A	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr18:25532201A>C	uc002kwg.2	-	16	3096	c.2637T>G	c.(2635-2637)GGT>GGG	p.G879G	CDH2_uc010xbn.1_Silent_p.G848G	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	879	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding			ovary(3)|lung(1)	4						CCTGCTCACCACCACTACTTG	0.507		NaN									OREG0003876	type=REGULATORY REGION|Gene=CDH2|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	0	0	0	0.004007	0	14	68				
MAPRE2	10982	broad.mit.edu	37	18	32621508	32621508	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr18:32621508C>T	uc002kyg.2	+	1	185	c.5C>T	c.(4-6)CCT>CTT	p.P2L	MAPRE2_uc010xcb.1_Intron|MAPRE2_uc010xcc.1_Intron|MAPRE2_uc002kyf.2_Missense_Mutation_p.P2L|MAPRE2_uc002kyh.2_5'UTR|MAPRE2_uc010xcd.1_5'Flank	NM_014268	NP_055083	Q15555	MARE2_HUMAN	microtubule-associated protein, RP/EB family,	2					cell division|cell proliferation|mitosis|signal transduction	cytoplasm|microtubule	microtubule binding			ovary(1)	1						GCGCCAATGCCTGGGCCGACC	0.612		NaN											0	0	0	0.00361	0	75	83				
PIK3C3	5289	broad.mit.edu	37	18	39637870	39637870	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr18:39637870G>A	uc002lap.2	+	22	2345	c.2287G>A	c.(2287-2289)GGA>AGA	p.G763R	PIK3C3_uc010xcl.1_Missense_Mutation_p.G700R|PIK3C3_uc002laq.2_Missense_Mutation_p.G248R	NM_002647	NP_002638	Q8NEB9	PK3C3_HUMAN	catalytic phosphatidylinositol 3-kinase 3	763	PI3K/PI4K.				cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			lung(8)|ovary(1)|breast(1)	10						CATAGACTTTGGATATATTTT	0.418		NaN								TSP Lung(28;0.18)			0	0	0	0.000978	0	9	14				
MAPK4	5596	broad.mit.edu	37	18	48255680	48255680	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr18:48255680G>A	uc002lev.2	+	6	2220	c.1220G>A	c.(1219-1221)CGC>CAC	p.R407H	MAPK4_uc010xdm.1_Missense_Mutation_p.R196H|MAPK4_uc010doz.2_3'UTR	NM_002747	NP_002738	P31152	MK04_HUMAN	mitogen-activated protein kinase 4	407					cell cycle		ATP binding|MAP kinase activity			lung(4)|skin(2)	6		Colorectal(6;0.0297)		Colorectal(21;0.156)		AGCTCCGAGCGCTTCCTAGAG	0.692		NaN											0	0	0	0.00499	0	14	9				
APC2	10297	broad.mit.edu	37	19	1462114	1462114	+	Silent	SNP	C	C	T	rs142142534		TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:1462114C>T	uc002lsr.1	+	14	1999	c.1791C>T	c.(1789-1791)ATC>ATT	p.I597I	APC2_uc002lss.1_Silent_p.I179I|APC2_uc002lst.1_Silent_p.I597I|APC2_uc002lsu.1_Silent_p.I596I|C19orf25_uc010xgn.1_Intron	NM_005883	NP_005874	O95996	APC2_HUMAN	adenomatosis polyposis coli 2	597	ARM 4.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|pancreas(1)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGGCCATCATCGAGAGCGGCG	0.667		NaN											0	0	0	0.00361	0	37	128				
ATP8B3	148229	broad.mit.edu	37	19	1785276	1785276	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:1785276G>C	uc002ltw.2	-	27	3648	c.3414C>G	c.(3412-3414)TAC>TAG	p.Y1138*	ATP8B3_uc002ltv.2_Nonsense_Mutation_p.Y1101*|ATP8B3_uc002ltx.2_RNA	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	1138	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGCGGTCCAGTACTTGATGA	0.607		NaN											0	0	0	0.001168	0	4	27				
FZR1	51343	broad.mit.edu	37	19	3534500	3534500	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:3534500C>T	uc010dtk.2	+	12	1463	c.1429C>T	c.(1429-1431)CGT>TGT	p.R477C	FZR1_uc002lxt.2_Missense_Mutation_p.R477C|FZR1_uc002lxv.2_Missense_Mutation_p.R388C	NM_001136198	NP_001129670	Q9UM11	FZR_HUMAN	Fzr1 protein isoform 1	477	WD 7.				activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|DNA repair|G2/M transition DNA damage checkpoint|mitosis|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding			lung(1)|kidney(1)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00253)|STAD - Stomach adenocarcinoma(1328;0.18)		TAGCAAAACCCGTTCGACAAA	0.627		NaN											0	0	0	0.009096	0	4	12				
ZBTB7A	51341	broad.mit.edu	37	19	4047820	4047820	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:4047820C>T	uc002lzh.2	-	3	1760	c.1685G>A	c.(1684-1686)GGT>GAT	p.G562D	ZBTB7A_uc002lzi.2_Missense_Mutation_p.G562D	NM_015898	NP_056982	O95365	ZBT7A_HUMAN	zinc finger and BTB domain containing 7A	562	Poly-Gly.				cell differentiation|multicellular organismal development|transcription, DNA-dependent	nucleus	DNA binding|histone acetyltransferase binding|zinc ion binding			pancreas(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.014)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCTCCTCCACCGGCGCCCGC	0.632		NaN											0	0	0	0.001882	0	16	69				
S1PR5	53637	broad.mit.edu	37	19	10625203	10625203	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:10625203G>A	uc002mot.1	-	2	542	c.485C>T	c.(484-486)TCG>TTG	p.S162L	S1PR5_uc002mou.1_Missense_Mutation_p.S162L	NM_030760	NP_110387	Q9H228	S1PR5_HUMAN	endothelial differentiation, sphingolipid	162	Helical; Name=4; (By similarity).					integral to membrane|plasma membrane	lysosphingolipid and lysophosphatidic acid receptor activity			central_nervous_system(1)|pancreas(1)	2						GAGGAGCAGCGACACGCCCCA	0.726		NaN											0	0	0	0.000978	0	9	9				
ZNF136	7695	broad.mit.edu	37	19	12298627	12298627	+	Silent	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:12298627T>C	uc002mti.2	+	4	1534	c.1434T>C	c.(1432-1434)TGT>TGC	p.C478C	ZNF136_uc010xmh.1_Silent_p.C412C	NM_003437	NP_003428	P52737	ZN136_HUMAN	zinc finger protein 136	478	C2H2-type 13.				negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			ovary(1)|pancreas(1)	2						CCTTTGAATGTAAGCGATGTG	0.418		NaN											0	0	0	0.008291	0	11	9				
JUNB	3726	broad.mit.edu	37	19	12903008	12903008	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:12903008A>C	uc002mvc.2	+	1	699	c.423A>C	c.(421-423)AAA>AAC	p.K141N	JUNB_uc002mvb.2_RNA	NM_002229	NP_002220	P17275	JUNB_HUMAN	jun B proto-oncogene	141						chromatin|nucleus	protein dimerization activity|transcription coactivator activity|transcription corepressor activity			lung(2)|central_nervous_system(1)	3						GCTTTGTCAAAGCCCTGGACG	0.567		NaN											0	0	0	0.001168	0	6	13				
JUNB	3726	broad.mit.edu	37	19	12903565	12903565	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:12903565A>G	uc002mvc.2	+	1	1256	c.980A>G	c.(979-981)AAG>AGG	p.K327R	JUNB_uc002mvb.2_RNA	NM_002229	NP_002220	P17275	JUNB_HUMAN	jun B proto-oncogene	327						chromatin|nucleus	protein dimerization activity|transcription coactivator activity|transcription corepressor activity			lung(2)|central_nervous_system(1)	3						CTCAAACAGAAGGTCATGACC	0.652		NaN											0	0	0	0.004656	0	22	27				
CPAMD8	27151	broad.mit.edu	37	19	17012070	17012070	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:17012070C>G	uc002nfb.2	-	36	4896	c.4864G>C	c.(4864-4866)GAG>CAG	p.E1622Q	CPAMD8_uc002nfd.1_Missense_Mutation_p.E87Q	NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	1575						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						AGGGGCACCTCCAGGACAGCC	0.607		NaN											0	0	0	0.004656	0	21	25				
ZNF737	100129842	broad.mit.edu	37	19	20728292	20728292	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:20728292G>C	uc002npa.2	-	4	897	c.717C>G	c.(715-717)AGC>AGG	p.S239R		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	239					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						ATGAAAACCGGCTAAAGGCTT	0.428		NaN											0	0	0	0.000602	0	5	7				
TSHZ3	57616	broad.mit.edu	37	19	31769651	31769651	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:31769651C>T	uc002nsy.3	-	2	1113	c.1048G>A	c.(1048-1050)GAT>AAT	p.D350N		NM_020856	NP_065907	Q63HK5	TSH3_HUMAN	zinc finger protein 537	350					negative regulation of transcription, DNA-dependent|regulation of respiratory gaseous exchange by neurological system process	growth cone|nucleus	chromatin binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(2)|pancreas(1)|lung(1)	8	Esophageal squamous(110;0.226)					TGAAGTGCATCGTTGGTGTCT	0.567		NaN											0	0	0	0.009718	0	36	117				
ZFP82	284406	broad.mit.edu	37	19	36883875	36883875	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:36883875C>T	uc002ody.1	-	5	1602	c.1367G>A	c.(1366-1368)GGC>GAC	p.G456D		NM_133466	NP_597723	Q8N141	ZFP82_HUMAN	zinc finger protein 82 homolog	456	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)|skin(1)	2						AAAGGCCTTGCCACATTCCTT	0.418		NaN											0	0	0	0.001855	0	14	9				
AXL	558	broad.mit.edu	37	19	41765721	41765721	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:41765721A>G	uc010ehj.2	+	20	2787	c.2597A>G	c.(2596-2598)TAT>TGT	p.Y866C	CYP2F1_uc010xvw.1_Intron|HNRNPUL1_uc002opz.3_5'Flank|HNRNPUL1_uc002oqa.3_5'Flank|AXL_uc010ehk.2_Missense_Mutation_p.Y857C|HNRNPUL1_uc010ehl.1_5'Flank	NM_021913	NP_068713	P30530	UFO_HUMAN	AXL receptor tyrosine kinase isoform 1	866	Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(4)|stomach(3)|ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	13						GCTGGACGCTATGTCCTCTGC	0.652		NaN											0	0	0	0.00361	0	61	59				
HNRNPUL1	11100	broad.mit.edu	37	19	41808694	41808694	+	Silent	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:41808694C>T	uc002oqb.3	+	12	2101	c.1812C>T	c.(1810-1812)CCC>CCT	p.P604P	CYP2F1_uc010xvw.1_Intron|HNRNPUL1_uc002opz.3_Silent_p.P504P|HNRNPUL1_uc002oqa.3_Silent_p.P504P|HNRNPUL1_uc010ehm.2_Silent_p.P604P|HNRNPUL1_uc002oqc.3_Silent_p.P490P|HNRNPUL1_uc002oqe.3_Intron|HNRNPUL1_uc002oqd.3_Silent_p.P504P|HNRNPUL1_uc010ehn.2_Silent_p.P504P|HNRNPUL1_uc010eho.2_Silent_p.P504P|HNRNPUL1_uc010xvy.1_Silent_p.P504P|HNRNPUL1_uc010ehp.2_Silent_p.P460P|HNRNPUL1_uc002oqf.3_Silent_p.P128P	NM_007040	NP_008971	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	604	Necessary for interaction with TP53.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			central_nervous_system(1)|skin(1)	2						CTGGGCCACCCCCTGAAAAGC	0.627		NaN											0	0	0	0.008871	0	18	55				
ARHGEF1	9138	broad.mit.edu	37	19	42402702	42402702	+	Silent	SNP	C	C	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:42402702C>G	uc002orx.2	+	14	1342	c.1233C>G	c.(1231-1233)CCC>CCG	p.P411P	ARHGEF1_uc002ory.2_Silent_p.P378P|ARHGEF1_uc002orz.2_Silent_p.P249P|ARHGEF1_uc002osa.2_Silent_p.P426P|ARHGEF1_uc002osb.2_Silent_p.P393P|ARHGEF1_uc002osc.2_Silent_p.P165P|ARHGEF1_uc002osd.2_Silent_p.P70P	NM_004706	NP_004697	Q92888	ARHG1_HUMAN	Rho guanine nucleotide exchange factor 1 isoform	411					cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(3)|large_intestine(1)	4		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)		ACAGCCTGCCCAAGAGCCAGG	0.652		NaN											0	0	0	0.004482	0	6	16				
ZNF233	353355	broad.mit.edu	37	19	44777421	44777421	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:44777421T>C	uc002oyz.1	+	5	735	c.608T>C	c.(607-609)GTA>GCA	p.V203A	ZNF235_uc002oyx.1_Intron|ZNF235_uc010eji.2_Intron|ZNF233_uc002oyy.1_Missense_Mutation_p.V18A	NM_181756	NP_861421	A6NK53	ZN233_HUMAN	zinc finger protein 233	203					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2		Prostate(69;0.0435)|all_neural(266;0.226)				CAAATTGATGTAAAAAATAAG	0.378		NaN											0	0	0	0.00308	0	7	9				
ERCC2	2068	broad.mit.edu	37	19	45867687	45867687	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08			T	C	T	T		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:45867687T>C	uc002pbj.2	-	8	760	c.713A>G	c.(712-714)AAC>AGC	p.N238S	ERCC2_uc002pbi.2_5'Flank|ERCC2_uc010ejz.2_Missense_Mutation_p.N160S|ERCC2_uc002pbk.2_Missense_Mutation_p.N214S|ERCC2_uc002pbl.3_Missense_Mutation_p.N214S|ERCC2_uc010xxj.1_Intron	NM_000400	NP_000391	P18074	ERCC2_HUMAN	excision repair cross-complementing rodent	238	Helicase ATP-binding.				cell cycle checkpoint|chromosome segregation|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein phosphorylation|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|UV protection|viral reproduction	cytoplasm|holo TFIIH complex|MMXD complex	5'-3' DNA helicase activity|ATP binding|ATP-dependent DNA helicase activity|DNA binding|iron-sulfur cluster binding|metal ion binding|protein C-terminus binding|protein N-terminus binding			lung(2)|pancreas(1)	3		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0226)		CTCACCAATGTTGTGGGCCTC	0.637		NaN	Mis|N|F|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.003163	0	15	39		Valid		
DMWD	1762	broad.mit.edu	37	19	46290118	46290118	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:46290118G>T	uc002pdj.1	-	3	682	c.636C>A	c.(634-636)GAC>GAA	p.D212E	DMWD_uc002pdk.1_Missense_Mutation_p.D212E|DMWD_uc010eko.1_5'UTR	NM_004943	NP_004934	Q09019	DMWD_HUMAN	dystrophia myotonica-containing WD repeat motif	212	WD 1.				meiosis						0		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00604)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.236)		CCTTGGTCTTGTCGATCAACC	0.582		NaN											1	0	1.5842e-08	0.001855	1.65358e-08	14	32				
STRN4	29888	broad.mit.edu	37	19	47226204	47226204	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:47226204T>C	uc002pfl.2	-	14	1802	c.1769A>G	c.(1768-1770)CAC>CGC	p.H590R	STRN4_uc002pfm.2_Missense_Mutation_p.H597R|STRN4_uc010xyf.1_RNA	NM_013403	NP_037535	Q9NRL3	STRN4_HUMAN	zinedin isoform 1	590	WD 4.					cytoplasm|membrane	armadillo repeat domain binding|calmodulin binding|protein complex binding|protein phosphatase 2A binding				0		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000563)|all cancers(93;0.00138)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.035)		GGGGACCCCGTGCTCTGAGGG	0.662		NaN											0	0	0	0.009535	0	27	67				
GPR77	27202	broad.mit.edu	37	19	47844239	47844239	+	Silent	SNP	G	G	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:47844239G>T	uc010ela.1	+	2	401	c.183G>T	c.(181-183)GGG>GGT	p.G61G	GPR77_uc002pgk.1_Silent_p.G61G	NM_018485	NP_060955	Q9P296	C5ARL_HUMAN	G protein-coupled receptor 77	61	Helical; Name=1; (Potential).				chemotaxis	integral to membrane|plasma membrane	C5a anaphylatoxin receptor activity			ovary(1)	1		all_cancers(25;1.72e-06)|all_lung(116;2.15e-05)|all_epithelial(76;3.44e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.0652)|Ovarian(192;0.086)		all cancers(93;0.000129)|OV - Ovarian serous cystadenocarcinoma(262;0.000415)|Epithelial(262;0.0109)|GBM - Glioblastoma multiforme(486;0.0138)		GGGTGGCTGGGAAGGTGGCCC	0.687		NaN											1	0	6.07207e-39	0.00361	6.94645e-39	76	258				
DHX34	9704	broad.mit.edu	37	19	47879304	47879304	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:47879304C>T	uc010xyn.1	+	11	2772	c.2431C>T	c.(2431-2433)CAG>TAG	p.Q811*	DHX34_uc010xyo.1_5'Flank	NM_014681	NP_055496	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	811						intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		CCTGTACCCACAGCTGGCCGT	0.607		NaN											0	0	0	0.006999	0	31	97				
MAMSTR	284358	broad.mit.edu	37	19	49217717	49217717	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:49217717T>A	uc002pkg.2	-	7	691	c.629A>T	c.(628-630)GAG>GTG	p.E210V	MAMSTR_uc002pkf.2_Missense_Mutation_p.E107V	NM_001130915	NP_001124387	Q6ZN01	MASTR_HUMAN	MEF2 activating motif and SAP domain containing	210	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding			ovary(1)	1						CTTcggccgctcgcggggcgg	0.617		NaN											0	0	0	0.00308	0	8	4				
RASIP1	54922	broad.mit.edu	37	19	49238543	49238543	+	Silent	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:49238543G>A	uc002pki.2	-	4	1286	c.1089C>T	c.(1087-1089)CCC>CCT	p.P363P		NM_017805	NP_060275	Q5U651	RAIN_HUMAN	Ras-interacting protein 1	363					signal transduction	Golgi stack|perinuclear region of cytoplasm				pancreas(1)	1		all_lung(116;4.89e-06)|all_epithelial(76;7.04e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000272)|Epithelial(262;0.0155)|GBM - Glioblastoma multiforme(486;0.0222)		CGAAGTCCCCGGGGTCTGCAG	0.672		NaN											0	0	0	0.010504	0	19	60				
HSD17B14	51171	broad.mit.edu	37	19	49316713	49316713	+	Silent	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:49316713C>T	uc002pkv.1	-	8	905	c.639G>A	c.(637-639)CAG>CAA	p.Q213Q	BCAT2_uc002pkq.3_5'Flank|BCAT2_uc002pkr.2_5'Flank|BCAT2_uc002pks.2_5'Flank|BCAT2_uc002pkt.2_5'Flank|BCAT2_uc010emh.1_5'Flank|BCAT2_uc010emi.1_5'Flank|BCAT2_uc010emj.1_5'Flank|HSD17B14_uc010emk.1_Intron	NM_016246	NP_057330	Q9BPX1	DHB14_HUMAN	dehydrogenase/reductase (SDR family) member 10	213					steroid catabolic process	centrosome|cytosol	estradiol 17-beta-dehydrogenase activity|protein binding|testosterone 17-beta-dehydrogenase (NADP+) activity				0		all_epithelial(76;7e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000341)|all cancers(93;0.000764)|GBM - Glioblastoma multiforme(486;0.0233)|Epithelial(262;0.0346)		CCACTTCTACCTGGGCCAGCA	0.607		NaN											0	0	0	0.004482	0	6	3				
FUZ	80199	broad.mit.edu	37	19	50315535	50315535	+	Silent	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:50315535T>C	uc002ppq.1	-	3	396	c.291A>G	c.(289-291)AGA>AGG	p.R97R	FUZ_uc002ppr.1_5'UTR|FUZ_uc002pps.1_Intron|FUZ_uc002ppt.1_Intron|FUZ_uc002ppu.1_Intron|FUZ_uc002ppv.1_Silent_p.R47R|FUZ_uc010ybd.1_Silent_p.R97R	NM_025129	NP_079405	Q9BT04	FUZZY_HUMAN	fuzzy homolog	97					cilium assembly|embryonic body morphogenesis|embryonic skeletal system morphogenesis|establishment of planar polarity|hair follicle development|neural tube closure|protein transport|regulation of smoothened signaling pathway	cytoplasm|cytoskeleton					0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00793)|GBM - Glioblastoma multiforme(134;0.0116)		TTTGGAGTAGTCTCTCCAGCC	0.333		NaN											0	0	0	0.004482	0	8	16				
MYH14	79784	broad.mit.edu	37	19	50735294	50735294	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:50735294C>T	uc002prr.1	+	9	1104	c.1057C>T	c.(1057-1059)CGG>TGG	p.R353W	MYH14_uc010enu.1_Missense_Mutation_p.R361W|MYH14_uc002prq.1_Missense_Mutation_p.R361W	NM_024729	NP_079005	Q7Z406	MYH14_HUMAN	myosin, heavy chain 14 isoform 2	353	Myosin head-like.				axon guidance|regulation of cell shape	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(1)	1		all_neural(266;0.0571)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00389)|GBM - Glioblastoma multiforme(134;0.0195)		GGAGTCGCTGCGGGTCCTGGG	0.662		NaN											0	0	0	0.010504	0	15	56				
ZNF616	90317	broad.mit.edu	37	19	52619312	52619312	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:52619312C>T	uc002pym.2	-	4	1388	c.1105G>A	c.(1105-1107)GTA>ATA	p.V369I	ZNF616_uc002pyn.2_RNA	NM_178523	NP_848618	Q08AN1	ZN616_HUMAN	zinc finger protein 616	369	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.00392)|OV - Ovarian serous cystadenocarcinoma(262;0.0189)		CGGTGACATACAAGATTTGAT	0.418		NaN											0	0	0	0.00361	0	47	58				
ZNF28	7576	broad.mit.edu	37	19	53311303	53311303	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:53311303G>T	uc002qad.2	-	3	219	c.99C>A	c.(97-99)TAC>TAA	p.Y33*	ZNF28_uc002qac.2_5'UTR|ZNF28_uc010eqe.2_Intron	NM_006969	NP_008900	P17035	ZNF28_HUMAN	zinc finger protein 28	33	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(134;0.0386)|Lung(386;0.145)		TCACATCCCTGTAAAGAGTCC	0.483		NaN											1	0	5.18039e-06	0.00308	5.32947e-06	7	77				
ZNF548	147694	broad.mit.edu	37	19	57910511	57910511	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:57910511T>C	uc002qom.2	+	3	1106	c.856T>C	c.(856-858)TGT>CGT	p.C286R	ZNF547_uc002qpm.3_Intron|ZNF548_uc002qon.2_Missense_Mutation_p.C289R	NM_152909	NP_690873	Q8NEK5	ZN548_HUMAN	zinc finger protein 548	286	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GTGCAACACATGTGGGAAATT	0.433		NaN											0	0	0	0.008291	0	9	20				
ZNF749	388567	broad.mit.edu	37	19	57956154	57956154	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:57956154C>G	uc002qoq.2	+	3	1892	c.1638C>G	c.(1636-1638)CAC>CAG	p.H546Q	ZNF547_uc002qpm.3_Intron	NM_001023561	NP_001018855	O43361	ZN749_HUMAN	zinc finger protein 749	546					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)|Lung(386;0.177)		TCATTCAACACAAGAGGATTG	0.463		NaN											0	0	0	0.008291	0	8	22				
ZNF329	79673	broad.mit.edu	37	19	58639356	58639356	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:58639356A>T	uc002qrn.2	-	4	1752	c.1515T>A	c.(1513-1515)CAT>CAA	p.H505Q	ZNF329_uc010euk.1_RNA|ZNF329_uc002qro.1_RNA|ZNF329_uc002qrp.1_RNA	NM_024620	NP_078896	Q86UD4	ZN329_HUMAN	zinc finger protein 329	505	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.029)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)|Lung(386;0.216)		CCTCCCTGCTATGGAGTCTCT	0.512		NaN											0	0	0	0.00361	0	64	83				
ACP1	52	broad.mit.edu	37	2	275176	275176	+	Silent	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:275176C>T	uc002qwg.2	+	4	364	c.268C>T	c.(268-270)CTA>TTA	p.L90L	ACP1_uc002qwh.2_RNA|ACP1_uc002qwf.2_Silent_p.L90L	NM_007099	NP_009030	P24666	PPAC_HUMAN	acid phosphatase 1, soluble isoform b	90						cytoplasm|internal side of plasma membrane|nucleus|soluble fraction	acid phosphatase activity|identical protein binding|non-membrane spanning protein tyrosine phosphatase activity			skin(1)	1	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.00175)|Lung NSC(108;0.216)|all_epithelial(98;0.236)		all cancers(51;0.000391)|Epithelial(75;0.00281)|OV - Ovarian serous cystadenocarcinoma(76;0.00542)|GBM - Glioblastoma multiforme(21;0.127)		TGATTATATACTATGTATGGA	0.343		NaN											0	0	0	0.009096	0	4	19				
RPS7	6201	broad.mit.edu	37	2	3623453	3623453	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:3623453G>A	uc002qxw.2	+	3	228	c.122G>A	c.(121-123)AGG>AAG	p.R41K	RPS7_uc002qxx.2_Missense_Mutation_p.R41K|RPS7_uc002qxy.2_5'Flank	NM_001011	NP_001002	P62081	RS7_HUMAN	ribosomal protein S7	41					endocrine pancreas development|ribosomal small subunit biogenesis|rRNA processing|translational elongation|translational termination|viral transcription	90S preribosome|cytosolic small ribosomal subunit|nucleolus|small-subunit processome	protein binding|RNA binding|structural constituent of ribosome				0	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.093)			OV - Ovarian serous cystadenocarcinoma(76;0.0963)|Epithelial(75;0.208)		GCTCAGCTCAGGGAGCTGAAT	0.637		NaN											0	0	0	0.006214	0	7	17				
GREB1	9687	broad.mit.edu	37	2	11758611	11758611	+	Missense_Mutation	SNP	C	C	T	rs71446422		TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:11758611C>T	uc002rbk.1	+	22	3910	c.3610C>T	c.(3610-3612)CTC>TTC	p.L1204F	GREB1_uc002rbp.1_Missense_Mutation_p.L202F	NM_014668	NP_055483	Q4ZG55	GREB1_HUMAN	growth regulation by estrogen in breast cancer 1	1204	Ser-rich.					integral to membrane				ovary(1)	1	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.115)|OV - Ovarian serous cystadenocarcinoma(76;0.186)		CGACTGTAGCCTCAGGACCGG	0.701		NaN											0	0	0	0.001882	0	20	19				
FAM84A	151354	broad.mit.edu	37	2	14774804	14774804	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:14774804C>T	uc002rbz.1	+	2	943	c.701C>T	c.(700-702)GCA>GTA	p.A234V	FAM84A_uc002rca.1_5'Flank	NM_145175	NP_660158	Q96KN4	FA84A_HUMAN	family with sequence similarity 84, member A	234										pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)		GBM - Glioblastoma multiforme(1;0.00969)			GAGGTGCCGGCAGGCACGCAG	0.642		NaN											0	0	0	0.001855	0	11	5				
FBXO11	80204	broad.mit.edu	37	2	48061799	48061799	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:48061799C>T	uc010fbl.2	-	7	715	c.601G>A	c.(601-603)GAT>AAT	p.D201N	FBXO11_uc002rwe.2_Missense_Mutation_p.D201N|FBXO11_uc002rwf.2_Missense_Mutation_p.D201N|FBXO11_uc002rwg.1_Missense_Mutation_p.D201N|FBXO11_uc010fbk.2_5'Flank	NM_025133	NP_079409	Q86XK2	FBX11_HUMAN	F-box only protein 11 isoform 1	285					ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|ubiquitin ligase complex	protein binding|protein-arginine N-methyltransferase activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|lung(1)	2		Acute lymphoblastic leukemia(82;0.0299)|all_hematologic(82;0.0358)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			ATAAGTCCATCAAAATGAGCC	0.328		NaN											0	0	0	0.008291	0	7	14				
STON1-GTF2A1L	286749	broad.mit.edu	37	2	48809237	48809237	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:48809237A>G	uc010yol.1	+	1	1512	c.1465A>G	c.(1465-1467)AAG>GAG	p.K489E	STON1_uc002rwo.3_Missense_Mutation_p.K489E|STON1_uc010fbm.2_Missense_Mutation_p.K489E|STON1-GTF2A1L_uc002rwp.1_Missense_Mutation_p.K489E|STON1_uc002rwr.2_RNA|STON1_uc002rwq.2_Missense_Mutation_p.K489E	NM_006873	NP_006864	B7ZL16	B7ZL16_HUMAN	stonin 1	489					endocytosis|intracellular protein transport|transcription initiation from RNA polymerase II promoter	clathrin adaptor complex|transcription factor TFIIA complex				ovary(3)|pancreas(1)|skin(1)	5		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)			CCATTTTCATAAGTGTGTGAA	0.378		NaN											0	0	0	0.004007	0	17	14				
GPR75	10936	broad.mit.edu	37	2	54080390	54080390	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:54080390G>T	uc002rxo.3	-	2	1775	c.1504C>A	c.(1504-1506)CCA>ACA	p.P502T	ASB3_uc002rxi.3_Intron	NM_006794	NP_006785	O95800	GPR75_HUMAN	G protein-coupled receptor 75	502	Cytoplasmic (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|skin(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			GAGTTTACTGGCTGTAAGTTA	0.458		NaN											1	0	2.61193e-14	0.009535	2.84396e-14	29	93				
SLC1A4	6509	broad.mit.edu	37	2	65248205	65248205	+	Silent	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:65248205C>T	uc010yqa.1	+	8	1846	c.1524C>T	c.(1522-1524)CCC>CCT	p.P508P	SLC1A4_uc010ypy.1_Silent_p.P288P|SLC1A4_uc010ypz.1_Silent_p.P210P|SLC1A4_uc010fcv.2_3'UTR|SLC1A4_uc002sdh.2_Silent_p.P288P	NM_003038	NP_003029	P43007	SATT_HUMAN	solute carrier family 1, member 4 isoform 1	508					cellular nitrogen compound metabolic process|cognition|synaptic transmission, glutamatergic	intermediate filament|melanosome	chloride channel activity|L-alanine transmembrane transporter activity|L-cystine transmembrane transporter activity|L-hydroxyproline transmembrane transporter activity|L-proline transmembrane transporter activity|L-serine transmembrane transporter activity|L-threonine transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(1)	1					L-Alanine(DB00160)	AGACATCGCCCCTGGTGACAC	0.587		NaN											0	0	0	0.00333	0	21	105				
LOXL3	84695	broad.mit.edu	37	2	74762468	74762468	+	Silent	SNP	G	G	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:74762468G>C	uc002smp.1	-	9	1602	c.1530C>G	c.(1528-1530)ACC>ACG	p.T510T	LOXL3_uc002smo.1_Silent_p.T149T|LOXL3_uc010ffm.1_Silent_p.T454T|LOXL3_uc002smq.1_Silent_p.T365T|LOXL3_uc010ffn.1_Silent_p.T365T	NM_032603	NP_115992	P58215	LOXL3_HUMAN	lysyl oxidase-like 3 precursor	510	SRCR 4.					extracellular space|membrane	copper ion binding|protein-lysine 6-oxidase activity|scavenger receptor activity				0						TCCTCTTGCAGGTGATGTGGG	0.582		NaN											0	0	0	0.00874	0	38	38				
RNF181	51255	broad.mit.edu	37	2	85823723	85823723	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:85823723G>T	uc002spv.1	+	2	218	c.168G>T	c.(166-168)AAG>AAT	p.K56N		NM_016494	NP_057578	Q9P0P0	RN181_HUMAN	ring finger protein 181	56							ligase activity|zinc ion binding				0						CAGCTGCCAAGACTGTGGTTG	0.537		NaN											1	0	2.98393e-07	0.00278	3.09953e-07	20	28				
AFF3	3899	broad.mit.edu	37	2	100343579	100343579	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:100343579C>T	uc002tag.2	-	10	1287	c.1051G>A	c.(1051-1053)GCA>ACA	p.A351T	AFF3_uc002taf.2_Missense_Mutation_p.A376T|AFF3_uc010fiq.1_Missense_Mutation_p.A351T|AFF3_uc010yvr.1_Missense_Mutation_p.A505T|AFF3_uc002tah.1_Missense_Mutation_p.A376T|AFF3_uc010fir.1_Missense_Mutation_p.A428T	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	351					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						TCTGGCTCTGCATCACCTTTC	0.353		NaN											0	0	0	0.000978	0	10	11				
IL18RAP	8807	broad.mit.edu	37	2	103068609	103068609	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:103068609A>G	uc002tbx.2	+	12	2252	c.1768A>G	c.(1768-1770)ACT>GCT	p.T590A	IL18RAP_uc010fiz.2_Missense_Mutation_p.T448A	NM_003853	NP_003844	O95256	I18RA_HUMAN	interleukin 18 receptor accessory protein	590	Cytoplasmic (Potential).				cell surface receptor linked signaling pathway|inflammatory response|innate immune response	integral to membrane	transmembrane receptor activity			skin(3)|ovary(2)	5						AACAGAAACCACTGGGAGGAG	0.512		NaN											0	0	0	0.00245	0	11	33				
RGPD3	653489	broad.mit.edu	37	2	107073498	107073498	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:107073498C>T	uc010ywi.1	-	4	391	c.334G>A	c.(334-336)GGA>AGA	p.G112R		NM_001144013	NP_001137485	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	112					intracellular transport		binding			ovary(1)	1						TCTGCTCTTCCATCAGTAACA	0.343		NaN											0	0	0	0.00333	0	19	29				
NCKAP5	344148	broad.mit.edu	37	2	133540952	133540952	+	Silent	SNP	A	A	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:133540952A>G	uc002ttp.2	-	14	3806	c.3432T>C	c.(3430-3432)ACT>ACC	p.T1144T	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1144							protein binding				0						CTGGAAGGCGAGTTTTCAGTC	0.483		NaN											0	0	0	0.003163	0	13	49				
R3HDM1	23518	broad.mit.edu	37	2	136409597	136409597	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:136409597C>T	uc002tuo.2	+	17	2288	c.1918C>T	c.(1918-1920)CCA>TCA	p.P640S	R3HDM1_uc010fni.2_Missense_Mutation_p.P639S|R3HDM1_uc002tup.2_Missense_Mutation_p.P585S|R3HDM1_uc010zbh.1_Missense_Mutation_p.P388S	NM_015361	NP_056176	Q15032	R3HD1_HUMAN	R3H domain containing 1	640							nucleic acid binding			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.127)		GCAGCCATCACCACAGGTATA	0.423		NaN											0	0	0	0.005524	0	34	33				
ARL6IP6	151188	broad.mit.edu	37	2	153575447	153575447	+	Silent	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:153575447G>A	uc002tyn.2	+	1	1025	c.309G>A	c.(307-309)CGG>CGA	p.R103R	ARL6IP6_uc002tym.2_Intron|ARL6IP6_uc002tyo.2_5'Flank|PRPF40A_uc002tyh.3_5'Flank|PRPF40A_uc010zcd.1_5'Flank|PRPF40A_uc002tyi.2_5'Flank|PRPF40A_uc002tyj.2_5'Flank|PRPF40A_uc002tyl.1_5'Flank	NM_152522	NP_689735	Q8N6S5	AR6P6_HUMAN	ADP-ribosylation-like factor 6 interacting	103						integral to membrane					0						AGCCTCGGCGGTGGCCGGTCC	0.632		NaN											0	0	0	0.002445	0	25	35				
PKP4	8502	broad.mit.edu	37	2	159517954	159517954	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:159517954G>A	uc002tzv.2	+	13	2463	c.2203G>A	c.(2203-2205)GAC>AAC	p.D735N	PKP4_uc002tzt.1_Missense_Mutation_p.D587N|PKP4_uc002tzu.2_Missense_Mutation_p.D735N|PKP4_uc002tzw.2_Missense_Mutation_p.D735N|PKP4_uc002tzx.2_Missense_Mutation_p.D392N|PKP4_uc002tzy.1_Missense_Mutation_p.D393N|PKP4_uc002uaa.2_Missense_Mutation_p.D587N|uc002uab.1_RNA|PKP4_uc002uac.2_5'Flank	NM_003628	NP_003619	Q99569	PKP4_HUMAN	plakophilin 4 isoform a	735	ARM 6.				cell adhesion	desmosome	protein binding			ovary(5)|skin(2)	7						ATCCGATTACGACAGCAAGGT	0.572		NaN								HNSCC(62;0.18)			0	0	0	0.004878	0	28	140				
PLA2R1	22925	broad.mit.edu	37	2	160876633	160876633	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:160876633A>G	uc002ube.1	-	8	1643	c.1436T>C	c.(1435-1437)GTC>GCC	p.V479A	PLA2R1_uc010zcp.1_Missense_Mutation_p.V479A|PLA2R1_uc002ubf.2_Missense_Mutation_p.V479A	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	479	Extracellular (Potential).|C-type lectin 2.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						CTCTGCTGAGACACACAGCTG	0.264		NaN											0	0	0	0.00245	0	12	20				
SCN2A	6326	broad.mit.edu	37	2	166231239	166231239	+	Missense_Mutation	SNP	T	T	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:166231239T>G	uc002udc.2	+	22	4307	c.4017T>G	c.(4015-4017)AAT>AAG	p.N1339K	SCN2A_uc002udd.2_Missense_Mutation_p.N1339K|SCN2A_uc002ude.2_Missense_Mutation_p.N1339K	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	1339	III.				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	CTATCATGAATGTACTTCTGG	0.363		NaN											0	0	0	0.004007	0	13	18				
SCN9A	6335	broad.mit.edu	37	2	167056069	167056069	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:167056069T>C	uc010fpl.2	-	27	5388	c.5047A>G	c.(5047-5049)ATT>GTT	p.I1683V	uc002udp.2_Intron	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	1694	IV.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	GAGGTTGTAATTTGGAACAGG	0.408		NaN											0	0	0	0.00874	0	34	95				
XIRP2	129446	broad.mit.edu	37	2	168100155	168100156	+	Missense_Mutation	DNP	GC	GC	AT			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:168100155_168100156GC>AT	uc002udx.2	+	8	2271_2272	c.2253_2254GC>AT	c.(2251-2256)ATGCTG>ATATTG	p.M751I	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.M576I|XIRP2_uc010fpq.2_Missense_Mutation_p.M529I|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	576					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						CGGGCCAAATGCTGGAAATTAA	0.366		NaN											0	0	0	0.004672	0	4	24				
TTN	7273	broad.mit.edu	37	2	179472309	179472309	+	Silent	SNP	A	A	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:179472309A>C	uc010zfg.1	-	226	45626	c.45402T>G	c.(45400-45402)CCT>CCG	p.P15134P	uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.P8829P|TTN_uc010zfi.1_Silent_p.P8762P|TTN_uc010zfj.1_Silent_p.P8637P	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	16061							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATACTTTTGTAGGTACAGGGC	0.453		NaN											0	0	0	0.00361	0	41	134				
ZC3H15	55854	broad.mit.edu	37	2	187371546	187371546	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:187371546A>G	uc002upo.2	+	9	1298	c.1073A>G	c.(1072-1074)TAT>TGT	p.Y358C		NM_018471	NP_060941	Q8WU90	ZC3HF_HUMAN	erythropoietin 4 immediate early response	358						cytoplasm|nucleolus|plasma membrane	nucleic acid binding|zinc ion binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Epithelial(96;0.0922)|all cancers(119;0.233)			TTCAGCACATATACTTCAGAT	0.313		NaN											0	0	0	0.00245	0	11	33				
ITGAV	3685	broad.mit.edu	37	2	187533614	187533614	+	Silent	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:187533614T>C	uc002upq.2	+	25	2835	c.2559T>C	c.(2557-2559)ACT>ACC	p.T853T	ITGAV_uc010frs.2_Silent_p.T817T|ITGAV_uc010zfv.1_Silent_p.T807T	NM_002210	NP_002201	P06756	ITAV_HUMAN	integrin alpha-V isoform 1 precursor	853	Extracellular (Potential).				angiogenesis|axon guidance|blood coagulation|cell-matrix adhesion|entry of bacterium into host cell|entry of symbiont into host cell by promotion of host phagocytosis|entry of virus into host cell|ERK1 and ERK2 cascade|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|negative regulation of lipid storage|negative regulation of lipid transport|negative regulation of lipoprotein metabolic process|negative regulation of low-density lipoprotein particle receptor biosynthetic process|negative regulation of macrophage derived foam cell differentiation|positive regulation of cell adhesion|positive regulation of cell proliferation|regulation of apoptotic cell clearance	integrin complex	receptor activity|transforming growth factor beta binding			ovary(2)|kidney(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.0185)|Epithelial(96;0.072)|all cancers(119;0.189)	STAD - Stomach adenocarcinoma(3;0.106)|COAD - Colon adenocarcinoma(31;0.108)		TGAACTGCACTTCAGATATGG	0.343		NaN											0	0	0	0.00333	0	19	27				
MYO1B	4430	broad.mit.edu	37	2	192194756	192194756	+	Splice_Site	SNP	G	G	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:192194756G>T	uc010fsg.2	+	4	601	c.346_splice	c.e4+1	p.E116_splice	MYO1B_uc002usq.2_Splice_Site_p.E116_splice|MYO1B_uc002usr.2_Splice_Site_p.E116_splice|MYO1B_uc002uss.1_Splice_Site_p.E116_splice	NM_001130158	NP_001123630	O43795	MYO1B_HUMAN	myosin IB isoform 1							myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			central_nervous_system(5)|large_intestine(2)|ovary(1)	8			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.104)|all cancers(119;0.236)			GGAAAAACAGGTAAGGCTCCT	0.483		NaN											1	0	5.03518e-11	0.007413	5.37337e-11	19	25				
SLC39A10	57181	broad.mit.edu	37	2	196581642	196581642	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:196581642G>A	uc002utg.3	+	7	2192	c.1978G>A	c.(1978-1980)GAT>AAT	p.D660N	SLC39A10_uc002uth.3_Missense_Mutation_p.D660N|SLC39A10_uc010zgp.1_Missense_Mutation_p.D210N	NM_001127257	NP_001120729	Q9ULF5	S39AA_HUMAN	solute carrier family 39 (zinc transporter),	660					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			pancreas(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.221)			TTCTGGATCCGATCTGAAAGA	0.493		NaN											0	0	0	0.004007	0	15	70				
ALS2	57679	broad.mit.edu	37	2	202593268	202593268	+	Silent	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:202593268G>A	uc002uyo.2	-	15	3164	c.2808C>T	c.(2806-2808)TTC>TTT	p.F936F	ALS2_uc002uyp.3_Silent_p.F936F|ALS2_uc010ftl.2_RNA	NM_020919	NP_065970	Q96Q42	ALS2_HUMAN	alsin isoform 1	936	PH.				cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	protein homodimerization activity|protein serine/threonine kinase activator activity|Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity			skin(5)|lung(1)|breast(1)	7						TAAAGAGAATGAACCAATTCA	0.488		NaN											0	0	0	0.001168	0	6	47				
FZD7	8324	broad.mit.edu	37	2	202899544	202899544	+	Silent	SNP	G	G	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:202899544G>C	uc002uyw.1	+	1	235	c.174G>C	c.(172-174)ACG>ACC	p.T58T		NM_003507	NP_003498	O75084	FZD7_HUMAN	frizzled 7 precursor	58	FZ.|Extracellular (Potential).				axonogenesis|brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|mesenchymal to epithelial transition|negative regulation of cell-substrate adhesion|negative regulation of ectodermal cell fate specification|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of phosphorylation|positive regulation of transcription, DNA-dependent|regulation of catenin import into nucleus|vasculature development|Wnt receptor signaling pathway, calcium modulating pathway	apical part of cell|cytoplasm|integral to membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			skin(2)|ovary(1)|breast(1)	4						CGCTGTGCACGGACATCGCCT	0.672		NaN											0	0	0	0.00361	0	61	188				
PTPRN	5798	broad.mit.edu	37	2	220166979	220166979	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:220166979T>C	uc002vkz.2	-	6	963	c.874A>G	c.(874-876)AGG>GGG	p.R292G	PTPRN_uc010zlc.1_Missense_Mutation_p.R202G|PTPRN_uc002vla.2_Missense_Mutation_p.R292G	NM_002846	NP_002837	Q16849	PTPRN_HUMAN	protein tyrosine phosphatase, receptor type, N	292	Extracellular (Potential).				response to reactive oxygen species	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(2)|lung(1)|skin(1)	4		Renal(207;0.0474)		Epithelial(149;4.22e-07)|all cancers(144;8.82e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)|STAD - Stomach adenocarcinoma(1183;0.0875)		CTTGGCACCCTGGCCCTGCTG	0.632		NaN											0	0	0	0.00623	0	37	16				
COL4A3	1285	broad.mit.edu	37	2	228113226	228113226	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:228113226C>T	uc002vom.1	+	9	698	c.536C>T	c.(535-537)CCA>CTA	p.P179L	COL4A3_uc002von.1_Missense_Mutation_p.P179L|COL4A3_uc002voo.1_Missense_Mutation_p.P179L|COL4A3_uc002vop.1_Missense_Mutation_p.P179L|uc002voq.1_Intron|uc002vor.1_Intron	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	179	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		CCAGGGGCTCCAGGACCCCAG	0.333		NaN											0	0	0	0.003163	0	12	6				
ALPI	248	broad.mit.edu	37	2	233322746	233322746	+	Nonsense_Mutation	SNP	C	C	T	rs147248868		TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:233322746C>T	uc002vst.3	+	8	972	c.895C>T	c.(895-897)CGA>TGA	p.R299*	ALPI_uc002vsu.3_Nonsense_Mutation_p.R210*	NM_001631	NP_001622	P09923	PPBI_HUMAN	intestinal alkaline phosphatase precursor	299					phosphorylation	anchored to membrane|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding|protein binding			central_nervous_system(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;1.64e-16)|Kidney(3;9.71e-08)|KIRC - Kidney renal clear cell carcinoma(3;2.74e-06)|BRCA - Breast invasive adenocarcinoma(100;0.000763)|Lung(119;0.00564)|LUSC - Lung squamous cell carcinoma(224;0.00746)		TGAGATCCACCGAGACCCCAC	0.617		NaN											0	0	0	0.00361	0	62	28				
USP40	55230	broad.mit.edu	37	2	234460031	234460031	+	Silent	SNP	A	A	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:234460031A>G	uc010zmu.1	-	7	946	c.828T>C	c.(826-828)TTT>TTC	p.F276F	USP40_uc010zmr.1_Silent_p.F288F|USP40_uc010zmt.1_5'Flank			Q9NVE5	UBP40_HUMAN	SubName: Full=cDNA FLJ56772, highly similar to Ubiquitin carboxyl-terminal hydrolase 40 (EC 3.1.2.15);	276					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(1)|lung(1)|breast(1)	3		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0539)		Epithelial(121;1.71e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000407)|Lung(119;0.00277)|LUSC - Lung squamous cell carcinoma(224;0.00646)		CCTGTTCACAAAAGGGCTTGA	0.323		NaN											0	0	0	0.006214	0	6	1				
KLHL30	377007	broad.mit.edu	37	2	239054468	239054468	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:239054468T>C	uc002vxr.1	+	4	1124	c.1091T>C	c.(1090-1092)ATC>ACC	p.I364T		NM_198582	NP_940984	Q0D2K2	KLH30_HUMAN	kelch-like 30	382	Kelch 3.										0		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		ATCTACGTTATCGGCGGTGAG	0.657		NaN											0	0	0	0.002445	0	25	7				
PLCB1	23236	broad.mit.edu	37	20	8862423	8862423	+	Missense_Mutation	SNP	T	T	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr20:8862423T>G	uc002wnb.2	+	32	3581	c.3578T>G	c.(3577-3579)GTG>GGG	p.V1193G	PLCB1_uc002wna.2_3'UTR	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	1193					activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						CCTGGAAAAGTGAACCACAAG	0.502		NaN											0	0	0	0.00361	0	59	68				
SEL1L2	80343	broad.mit.edu	37	20	13856714	13856714	+	Silent	SNP	G	G	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr20:13856714G>C	uc010gcf.2	-	12	1156	c.1074C>G	c.(1072-1074)GCC>GCG	p.A358A	SEL1L2_uc002woq.3_Silent_p.A219A|SEL1L2_uc010zrl.1_Silent_p.A358A|SEL1L2_uc002wor.2_RNA	NM_025229	NP_079505	Q5TEA6	SE1L2_HUMAN	sel-1 suppressor of lin-12-like 2 precursor	358	Extracellular (Potential).|Sel1-like 6.					integral to membrane	binding			ovary(2)	2						AGTACTTGAAGGCAGTAGCGT	0.373		NaN											0	0	0	0.00632	0	23	94				
C20orf186	149954	broad.mit.edu	37	20	31688261	31688261	+	Silent	SNP	A	A	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr20:31688261A>G	uc010zue.1	+	12	1614	c.1599A>G	c.(1597-1599)ACA>ACG	p.T533T		NM_182519	NP_872325	P59827	LPLC4_HUMAN	antimicrobial peptide RY2G5 precursor	533						cytoplasm|extracellular region	lipid binding				0						CATTTTCCACAGAAGGAGATA	0.527		NaN											0	0	0	0.003163	0	5	33				
EDEM2	55741	broad.mit.edu	37	20	33735053	33735053	+	Silent	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr20:33735053G>A	uc002xbo.2	-	1	109	c.9C>T	c.(7-9)TTC>TTT	p.F3F	EDEM2_uc010zuv.1_Intron|EDEM2_uc010zus.1_5'Flank|EDEM2_uc002xbq.2_Silent_p.F3F|EDEM2_uc010zut.1_5'UTR|EDEM2_uc002xbp.2_5'UTR|EDEM2_uc002xbn.2_5'UTR|EDEM2_uc002xbr.2_RNA|EDEM2_uc010zuu.1_5'UTR	NM_018217	NP_060687	Q9BV94	EDEM2_HUMAN	ER degradation enhancer, mannosidase alpha-like	3					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane|extracellular region	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding				0			BRCA - Breast invasive adenocarcinoma(18;0.00936)			TGAGCAGCCGGAAAGGCATAG	0.677		NaN											0	0	0	0.00361	0	49	34				
CHD6	84181	broad.mit.edu	37	20	40049605	40049605	+	Silent	SNP	T	T	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr20:40049605T>A	uc002xka.1	-	31	5848	c.5670A>T	c.(5668-5670)GTA>GTT	p.V1890V		NM_032221	NP_115597	Q8TD26	CHD6_HUMAN	chromodomain helicase DNA binding protein 6	1890					chromatin remodeling|nervous system development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding			ovary(6)|skin(5)|lung(2)|central_nervous_system(1)	14		Myeloproliferative disorder(115;0.00425)				TGAGATGCAATACCTCTGGCC	0.388		NaN											0	0	0	0.003954	0	23	20				
KCNK15	60598	broad.mit.edu	37	20	43374640	43374640	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr20:43374640A>T	uc002xmr.2	+	1	153	c.89A>T	c.(88-90)GAG>GTG	p.E30V		NM_022358	NP_071753	Q9H427	KCNKF_HUMAN	potassium family, subfamily K, member 15	30						integral to membrane	potassium channel activity|voltage-gated ion channel activity				0		Myeloproliferative disorder(115;0.0122)				GACGCGCTCGAGTCCGAGGCG	0.721		NaN											0	0	0	0.009096	0	4	17				
STK4	6789	broad.mit.edu	37	20	43607147	43607147	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr20:43607147A>T	uc002xnb.2	+	3	270	c.180A>T	c.(178-180)CAA>CAT	p.Q60H	STK4_uc010ggx.2_Missense_Mutation_p.Q60H|STK4_uc010ggy.2_Missense_Mutation_p.Q60H|STK4_uc010ggw.1_Missense_Mutation_p.Q60H	NM_006282	NP_006273	Q13043	STK4_HUMAN	serine/threonine kinase 4	60	Protein kinase.				apoptosis|cell morphogenesis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of apoptosis|protein autophosphorylation	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein homodimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity|transcription factor binding			ovary(1)|skin(1)	2		Myeloproliferative disorder(115;0.0122)				CTATTAAGCAAGTTCCTGTGG	0.413		NaN											0	0	0	0.001855	0	11	28				
TAF4	6874	broad.mit.edu	37	20	60581776	60581776	+	Silent	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr20:60581776G>A	uc002ybs.2	-	7	2013	c.2013C>T	c.(2011-2013)TCC>TCT	p.S671S		NM_003185	NP_003176	O00268	TAF4_HUMAN	TBP-associated factor 4	671	TAFH.				interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|pancreas(1)	3	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			TGAAGGCCGCGGAGTCGGGGG	0.657		NaN											0	0	0	0.00361	0	99	93				
MRPS6	64968	broad.mit.edu	37	21	35497670	35497670	+	Silent	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr21:35497670G>A	uc002ytp.2	+	2	253	c.75G>A	c.(73-75)ACG>ACA	p.T25T		NM_032476	NP_115865	P82932	RT06_HUMAN	mitochondrial ribosomal protein S6	25					translation	mitochondrion|small ribosomal subunit	rRNA binding|structural constituent of ribosome			skin(1)	1						TGAAACGTACGATAGAGGCCC	0.418		NaN											0	0	0	0.00361	0	44	44				
DSCR6	53820	broad.mit.edu	37	21	38390265	38390265	+	Missense_Mutation	SNP	T	T	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr21:38390265T>G	uc002yvv.2	+	4	541	c.331T>G	c.(331-333)TTC>GTC	p.F111V	DSCR6_uc011aec.1_5'UTR|DSCR6_uc010gnd.2_5'UTR	NM_018962	NP_061835	P57055	DSCR6_HUMAN	Down syndrome critical region protein 6	111	Ripply homology domain.					nucleus				breast(1)	1		Myeloproliferative disorder(46;0.0632)				CACGATTGACTTCTACGACGA	0.537		NaN											0	0	0	0.00245	0	12	29				
TFF1	7031	broad.mit.edu	37	21	43786556	43786556	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr21:43786556T>C	uc002zax.1	-	1	89	c.49A>G	c.(49-51)ATG>GTG	p.M17V		NM_003225	NP_003216	P04155	TFF1_HUMAN	trefoil factor 1 precursor	17					carbohydrate metabolic process|response to estradiol stimulus		growth factor activity				0						AGGGCCAGCATGGACACCAGG	0.667		NaN											0	0	0	0.00333	0	20	46				
ICOSLG	23308	broad.mit.edu	37	21	45656811	45656811	+	Silent	SNP	C	C	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr21:45656811C>A	uc002zee.2	-	3	479	c.345G>T	c.(343-345)GTG>GTT	p.V115V	ICOSLG_uc011afc.1_Silent_p.V25V|ICOSLG_uc002zef.2_Intron|ICOSLG_uc010gpp.1_Silent_p.V115V	NM_015259	NP_056074	O75144	ICOSL_HUMAN	inducible T-cell co-stimulator ligand precursor	115	Ig-like V-type.|Extracellular (Potential).				B cell activation|defense response|hyperosmotic response|positive regulation of activated T cell proliferation|signal transduction|T cell activation|T cell costimulation		receptor binding				0				Colorectal(79;0.0163)|READ - Rectum adenocarcinoma(84;0.0772)		ATTGGCTCAACACCAGGCAGT	0.607		NaN											1	0	7.75977e-34	0.00361	8.83008e-34	57	90				
MCM3AP	8888	broad.mit.edu	37	21	47700482	47700482	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr21:47700482G>A	uc002zir.1	-	3	1487	c.1451C>T	c.(1450-1452)GCA>GTA	p.A484V		NM_003906	NP_003897	O60318	MCM3A_HUMAN	minichromosome maintenance complex component 3	484					DNA replication|protein import into nucleus	cytosol|nucleus	DNA binding|nucleotide binding			large_intestine(2)|lung(1)|ovary(1)|skin(1)	5	Breast(49;0.112)					AGCCAGGGCTGCAGATGCCTG	0.403		NaN											0	0	0	0.002299	0	17	30				
DGCR8	54487	broad.mit.edu	37	22	20074109	20074109	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr22:20074109A>G	uc002zri.2	+	2	973	c.623A>G	c.(622-624)AAT>AGT	p.N208S	DGCR8_uc010grz.2_Missense_Mutation_p.N208S|DGCR8_uc002zrj.2_5'Flank	NM_022720	NP_073557	Q8WYQ5	DGCR8_HUMAN	DiGeorge syndrome critical region gene 8	208	Necessary for nuclear localization and retention.|Necessary for interaction with NCL.				primary miRNA processing	cytoplasm|cytoplasm|microtubule cytoskeleton|nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding				0	Colorectal(54;0.0993)					TTTACTGACAATTTGGAGCTA	0.478		NaN											0	0	0	0.00361	0	47	19				
FOXRED2	80020	broad.mit.edu	37	22	36902136	36902136	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr22:36902136T>C	uc003apn.3	-	1	442	c.334A>G	c.(334-336)AGA>GGA	p.R112G	FOXRED2_uc003apo.3_Missense_Mutation_p.R112G|FOXRED2_uc003app.3_Missense_Mutation_p.R112G	NM_024955	NP_079231	Q8IWF2	FXRD2_HUMAN	FAD-dependent oxidoreductase domain containing 2	112					ER-associated protein catabolic process	endoplasmic reticulum lumen	flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			lung(1)|kidney(1)	2						GAGTAGTGTCTGAAGAGCAGC	0.627		NaN											0	0	0	0.00361	0	96	52				
CSF2RB	1439	broad.mit.edu	37	22	37318275	37318275	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr22:37318275C>A	uc003aqa.3	+	2	243	c.26C>A	c.(25-27)TCC>TAC	p.S9Y	CSF2RB_uc003aqc.3_Missense_Mutation_p.S9Y	NM_000395	NP_000386	P32927	IL3RB_HUMAN	colony stimulating factor 2 receptor, beta	9					respiratory gaseous exchange	granulocyte macrophage colony-stimulating factor receptor complex	cytokine receptor activity			skin(2)|pancreas(1)	3					Sargramostim(DB00020)	GGGCTGCTCTCCATGGCCCTG	0.672		NaN											1	0	4.22769e-11	0.00632	4.5229e-11	20	6				
ARFGAP3	26286	broad.mit.edu	37	22	43218291	43218291	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr22:43218291G>C	uc003bdd.2	-	9	1017	c.797C>G	c.(796-798)TCT>TGT	p.S266C	ARFGAP3_uc010gzf.2_Missense_Mutation_p.S222C|ARFGAP3_uc011apu.1_Missense_Mutation_p.S194C	NM_014570	NP_055385	Q9NP61	ARFG3_HUMAN	ADP-ribosylation factor GTPase activating	266					intracellular protein transport|protein secretion|regulation of ARF GTPase activity|vesicle-mediated transport	cytosol|Golgi membrane	ARF GTPase activator activity|protein transporter activity|zinc ion binding			breast(1)	1						TTCTTCTTTAGATACCACCTT	0.338		NaN											0	0	0	0.001882	0	19	12				
EDEM1	9695	broad.mit.edu	37	3	5229970	5229970	+	Silent	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:5229970C>T	uc003bqi.2	+	1	612	c.480C>T	c.(478-480)TGC>TGT	p.C160C	EDEM1_uc011asz.1_5'UTR|EDEM1_uc003bqh.2_Silent_p.C160C	NM_014674	NP_055489	Q92611	EDEM1_HUMAN	ER degradation enhancer, mannosidase alpha-like	160	Lumenal (Potential).				ER-associated protein catabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	integral to endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			ovary(2)|breast(1)	3				Epithelial(13;0.0588)|OV - Ovarian serous cystadenocarcinoma(96;0.0682)		CCATCCACTGCCGCGGCCGTG	0.602		NaN											0	0	0	0.001882	0	16	31				
FBLN2	2199	broad.mit.edu	37	3	13659771	13659771	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:13659771G>T	uc011avb.1	+	6	2050	c.1925G>T	c.(1924-1926)CGC>CTC	p.R642L	FBLN2_uc011auz.1_Missense_Mutation_p.R668L|FBLN2_uc011ava.1_Missense_Mutation_p.R642L|FBLN2_uc011avc.1_Missense_Mutation_p.R642L	NM_001998	NP_001989	P98095	FBLN2_HUMAN	fibulin 2 isoform b precursor	642	EGF-like 1; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(1)	1			UCEC - Uterine corpus endometrioid carcinoma (1;0.00416)			GACGATGGCCGCACTTGCCGC	0.617		NaN											1	0	3.62473e-10	0.001882	3.83953e-10	19	50				
ANKRD28	23243	broad.mit.edu	37	3	15727600	15727600	+	Missense_Mutation	SNP	T	T	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:15727600T>G	uc003caj.1	-	20	2131	c.1988A>C	c.(1987-1989)AAC>ACC	p.N663T	ANKRD28_uc003cai.1_Missense_Mutation_p.N509T|ANKRD28_uc011avz.1_Missense_Mutation_p.N509T|ANKRD28_uc003cak.1_RNA|ANKRD28_uc011awa.1_RNA|ANKRD28_uc003cal.1_Missense_Mutation_p.N693T|ANKRD28_uc003cam.2_Missense_Mutation_p.N696T	NM_015199	NP_056014	O15084	ANR28_HUMAN	ankyrin repeat domain 28	663	ANK 19.					nucleoplasm	protein binding			breast(1)	1						TGTGTGCCCGTTGAGAACAGA	0.468		NaN											0	0	0	0.001168	0	5	12				
ZNF385D	79750	broad.mit.edu	37	3	21478519	21478519	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:21478519A>T	uc003cce.2	-	5	1024	c.616T>A	c.(616-618)TGT>AGT	p.C206S	ZNF385D_uc010hfb.1_RNA	NM_024697	NP_078973	Q9H6B1	Z385D_HUMAN	zinc finger protein 385D	206	Matrin-type 2.					nucleus	nucleic acid binding|zinc ion binding			large_intestine(2)|skin(2)|ovary(1)	5						CATAGCGAACAGTAAAGAAGC	0.483		NaN											0	0	0	0.007413	0	14	44				
SCAP	22937	broad.mit.edu	37	3	47484415	47484415	+	Silent	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:47484415T>C	uc003crh.1	-	2	324	c.69A>G	c.(67-69)GCA>GCG	p.A23A	SCAP_uc011baz.1_5'UTR|SCAP_uc003crg.2_5'UTR	NM_012235	NP_036367	Q12770	SCAP_HUMAN	SREBF chaperone protein	23	Helical; Name=1; (Potential).				cholesterol metabolic process|negative regulation of cholesterol biosynthetic process|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|Golgi membrane|integral to membrane	unfolded protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000278)|KIRC - Kidney renal clear cell carcinoma(197;0.00592)|Kidney(197;0.00679)		TGGGATAGGATGCACAGAGGA	0.542		NaN											0	0	0	0.001168	0	5	18				
RBM5	10181	broad.mit.edu	37	3	50144929	50144929	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:50144929C>T	uc003cyg.2	+	12	1116	c.968C>T	c.(967-969)TCA>TTA	p.S323L	RBM5_uc011bdj.1_Missense_Mutation_p.S267L|RBM5_uc011bdk.1_Missense_Mutation_p.S151L	NM_005778	NP_005769	P52756	RBM5_HUMAN	RNA binding motif protein 5	323	Required for interaction with U2AF2.				apoptosis|negative regulation of cell proliferation|positive regulation of apoptosis|regulation of alternative nuclear mRNA splicing, via spliceosome|spliceosome assembly	nucleoplasm|spliceosomal complex	DNA binding|mRNA binding|nucleotide binding|protein binding|zinc ion binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000121)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		TTGGTCCTCTCAGATGGTAAC	0.478		NaN											0	0	0	0.000978	0	9	21				
GRAMD1C	54762	broad.mit.edu	37	3	113563350	113563350	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:113563350G>A	uc003eaq.3	+	2	104	c.28G>A	c.(28-30)GTG>ATG	p.V10M	GRAMD1C_uc011bil.1_RNA|GRAMD1C_uc011bim.1_RNA	NM_017577	NP_060047	Q8IYS0	GRM1C_HUMAN	GRAM domain containing 1C	10						integral to membrane				ovary(2)|skin(1)	3						TTGTTTCCAGGTGATGAATGA	0.323		NaN											0	0	0	0.006214	0	9	20				
ITGB5	3693	broad.mit.edu	37	3	124540305	124540305	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:124540305C>T	uc003eho.2	-	6	1094	c.797G>A	c.(796-798)CGA>CAA	p.R266Q		NM_002213	NP_002204	P18084	ITB5_HUMAN	integrin, beta 5 precursor	266	VWFA.|Extracellular (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|multicellular organismal development|muscle contraction	integrin complex	receptor activity			skin(2)	2				GBM - Glioblastoma multiforme(114;0.163)		TGCATCCTTTCGCCAGCCAAT	0.567		NaN											0	0	0	0.003755	0	31	149				
COL6A6	131873	broad.mit.edu	37	3	130381085	130381085	+	Silent	SNP	C	C	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:130381085C>G	uc010htl.2	+	34	6466	c.6435C>G	c.(6433-6435)GGC>GGG	p.G2145G	COL6A6_uc003eni.3_Silent_p.G244G	NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	2145	VWFA 9.|Nonhelical region.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						TCCAGCTTGGCCGAATTCATA	0.448		NaN											0	0	0	0.005443	0	18	116				
NPHP3	27031	broad.mit.edu	37	3	132408036	132408036	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:132408036T>A	uc003epe.1	-	20	2842	c.2765A>T	c.(2764-2766)TAC>TTC	p.Y922F	NPHP3_uc003epd.1_Missense_Mutation_p.Y164F	NM_153240	NP_694972	Q7Z494	NPHP3_HUMAN	nephrocystin 3	922	TPR 3.				maintenance of organ identity|negative regulation of canonical Wnt receptor signaling pathway|photoreceptor cell maintenance|regulation of Wnt receptor signaling pathway, planar cell polarity pathway|Wnt receptor signaling pathway	cilium	protein binding			ovary(1)	1						TGAATCGAAGTATTCTGTTGC	0.408		NaN											0	0	0	0.002522	0	38	30				
CLSTN2	64084	broad.mit.edu	37	3	140277676	140277676	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:140277676C>G	uc003etn.2	+	12	2208	c.2018C>G	c.(2017-2019)GCC>GGC	p.A673G		NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	673	Extracellular (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						AAAACCGAAGCCCCCGGGGAC	0.502		NaN								HNSCC(16;0.037)			0	0	0	0.008871	0	17	26				
HPS3	84343	broad.mit.edu	37	3	148889891	148889891	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:148889891C>G	uc003ewu.1	+	17	3037	c.2897C>G	c.(2896-2898)TCA>TGA	p.S966*	CP_uc011bnr.1_Intron|HPS3_uc011bnq.1_Nonsense_Mutation_p.S801*|HPS3_uc003ewv.1_RNA	NM_032383	NP_115759	Q969F9	HPS3_HUMAN	Hermansky-Pudlak syndrome 3 protein	966						cytoplasm				ovary(5)|large_intestine(1)	6			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			GAAACATTGTCAATTGTTGCT	0.353		NaN							Hermansky-Pudlak_syndrome				0	0	0	0.00333	0	22	14				
FNDC3B	64778	broad.mit.edu	37	3	172064198	172064198	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:172064198A>T	uc003fhy.2	+	20	2504	c.2332A>T	c.(2332-2334)ACA>TCA	p.T778S	FNDC3B_uc003fhz.3_Missense_Mutation_p.T778S	NM_022763	NP_073600	Q53EP0	FND3B_HUMAN	fibronectin type III domain containing 3B	778	Fibronectin type-III 6.					endoplasmic reticulum|integral to membrane				ovary(2)|breast(1)	3	all_cancers(22;1.01e-18)|Ovarian(172;0.00167)|Breast(254;0.165)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)	GBM - Glioblastoma multiforme(1;0.0494)		TATTTCTTGTACACCTGATGG	0.423		NaN											0	0	0	0.00278	0	17	68				
TNFSF10	8743	broad.mit.edu	37	3	172227013	172227013	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:172227013A>G	uc003fid.2	-	4	507	c.412T>C	c.(412-414)TCT>CCT	p.S138P	TNFSF10_uc003fie.2_Intron	NM_003810	NP_003801	P50591	TNF10_HUMAN	tumor necrosis factor (ligand) superfamily,	138	Extracellular (Potential).				activation of caspase activity|activation of pro-apoptotic gene products|cell-cell signaling|immune response|induction of apoptosis by extracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|signal transduction	extracellular space|integral to plasma membrane|soluble fraction	cytokine activity|metal ion binding|tumor necrosis factor receptor binding			skin(4)|lung(1)	5	Ovarian(172;0.00197)|Breast(254;0.158)		Lung(28;1.67e-15)|LUSC - Lung squamous cell carcinoma(14;1.48e-14)|STAD - Stomach adenocarcinoma(35;0.235)			TTACTTGGAGAAGACAATGTG	0.358		NaN											0	0	0	0.001984	0	5	28				
LEPREL1	55214	broad.mit.edu	37	3	189690704	189690704	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:189690704T>C	uc011bsk.1	-	11	2046	c.1658A>G	c.(1657-1659)TAT>TGT	p.Y553C	LEPREL1_uc003fsg.2_Missense_Mutation_p.Y372C	NM_018192	NP_060662	Q8IVL5	P3H2_HUMAN	leprecan-like 1 isoform a	553					collagen metabolic process|negative regulation of cell proliferation|peptidyl-proline hydroxylation	basement membrane|endoplasmic reticulum|Golgi apparatus	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			breast(3)|ovary(1)	4	all_cancers(143;4.01e-10)|Ovarian(172;0.0925)		Lung(62;4.35e-05)	GBM - Glioblastoma multiforme(93;0.02)	L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	ATAGGAAAAATACAGAGTTGA	0.433		NaN											0	0	0	0.004289	0	31	21				
MUC20	200958	broad.mit.edu	37	3	195453217	195453217	+	Silent	SNP	C	C	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:195453217C>G	uc010hzo.2	+	3	1356	c.1230C>G	c.(1228-1230)CTC>CTG	p.L410L	MUC20_uc010hzp.2_Silent_p.L375L|MUC20_uc011bte.1_RNA	NM_152673	NP_689886	Q8N307	MUC20_HUMAN	mucin 20 isoform L	581	Involved in oligomerization.				protein homooligomerization	apical plasma membrane|basal plasma membrane|extracellular region|microvillus membrane					0	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)	Lung NSC(153;0.191)	Epithelial(36;1e-21)|all cancers(36;9.02e-20)|OV - Ovarian serous cystadenocarcinoma(49;1.6e-18)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;1.66e-05)		AAGCCGCCCTCAAGAACTTCA	0.597		NaN											0	0	0	0.004007	0	14	105				
MUC4	4585	broad.mit.edu	37	3	195512568	195512568	+	Silent	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr3:195512568T>C	uc011bto.1	-	2	6343	c.5883A>G	c.(5881-5883)GTA>GTG	p.V1961V	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GACCTGTGGGTACTGAGGAAG	0.602		NaN											0	0	0	0.004672	0	2	6				
HGFAC	3083	broad.mit.edu	37	4	3449359	3449359	+	Splice_Site	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr4:3449359G>A	uc003ghc.2	+	11	1498	c.1495_splice	c.e11+1	p.V499_splice	HGFAC_uc010icw.2_Splice_Site_p.V506_splice	NM_001528	NP_001519	Q04756	HGFA_HUMAN	HGF activator preproprotein						proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(2)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CACGACCTCGGTGAGCTCCGG	0.652		NaN											0	0	0	0.00361	0	216	288				
FBXL5	26234	broad.mit.edu	37	4	15626988	15626988	+	Silent	SNP	A	A	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr4:15626988A>C	uc003goc.1	-	9	1840	c.1737T>G	c.(1735-1737)CCT>CCG	p.P579P	FBXL5_uc010idw.1_Silent_p.P492P|FBXL5_uc003gob.1_Silent_p.P453P|FBXL5_uc010idx.1_Silent_p.P578P|FBXL5_uc003god.1_Silent_p.P562P|FBXL5_uc010idy.1_Silent_p.P579P	NM_012161	NP_036293	Q9UKA1	FBXL5_HUMAN	F-box and leucine-rich repeat protein 5 isoform	579	LRR 5.				iron ion homeostasis|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	perinuclear region of cytoplasm|SCF ubiquitin ligase complex	iron ion binding|protein binding|ubiquitin-protein ligase activity				0						CTTTTCCCCTAGGCAATCTAG	0.398		NaN											0	0	0	0.006214	0	8	10				
ARAP2	116984	broad.mit.edu	37	4	36231078	36231078	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr4:36231078T>C	uc003gsq.1	-	2	369	c.31A>G	c.(31-33)ATA>GTA	p.I11V	ARAP2_uc003gsr.1_Missense_Mutation_p.I11V	NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	11	SAM.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						AAATCTTTTATATCCACATTT	0.383		NaN											0	0	0	0.000978	0	8	35				
KCTD8	386617	broad.mit.edu	37	4	44177154	44177154	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr4:44177154T>C	uc003gwu.2	-	2	1359	c.1075A>G	c.(1075-1077)AGT>GGT	p.S359G		NM_198353	NP_938167	Q6ZWB6	KCTD8_HUMAN	potassium channel tetramerisation domain	359						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(2)|ovary(1)	3						CTGTCACAACTGGAAGTGGAG	0.468		NaN								HNSCC(17;0.042)			0	0	0	0.007413	0	17	38				
FRYL	285527	broad.mit.edu	37	4	48577219	48577219	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr4:48577219T>C	uc003gyh.1	-	25	3366	c.2761A>G	c.(2761-2763)ATA>GTA	p.I921V	FRYL_uc003gyk.2_Missense_Mutation_p.I921V	NM_015030	NP_055845	O94915	FRYL_HUMAN	furry-like	921					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			skin(1)	1						ATTGGAACTATGTGCTTAAAC	0.398		NaN											0	0	0	0.000602	0	5	28				
OCIAD1	54940	broad.mit.edu	37	4	48859275	48859275	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr4:48859275C>G	uc003gyo.2	+	8	850	c.593C>G	c.(592-594)ACA>AGA	p.T198R	OCIAD1_uc003gyr.2_Missense_Mutation_p.T198R|OCIAD1_uc003gyp.2_Intron|OCIAD1_uc003gys.2_Intron|OCIAD1_uc003gyq.2_Intron|OCIAD1_uc010igk.2_Missense_Mutation_p.T203R	NM_017830	NP_060300	Q9NX40	OCAD1_HUMAN	OCIA domain containing 1 isoform 1	198						endosome	protein binding				0						AAAAATATTACATATGAGGAA	0.333		NaN											0	0	0	0.001984	0	5	6				
SCFD2	152579	broad.mit.edu	37	4	54232001	54232001	+	Silent	SNP	C	C	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr4:54232001C>A	uc003gzu.2	-	1	242	c.108G>T	c.(106-108)CTG>CTT	p.L36L	SCFD2_uc010igm.2_Silent_p.L36L	NM_152540	NP_689753	Q8WU76	SCFD2_HUMAN	sec1 family domain containing 2	36					protein transport|vesicle docking involved in exocytosis					ovary(2)|pancreas(1)	3			GBM - Glioblastoma multiforme(3;1.07e-26)|LUSC - Lung squamous cell carcinoma(32;0.0134)			AGCCCCAGTGCAGGCTCTCGG	0.652		NaN											1	0	1.43161e-34	0.00361	1.63341e-34	67	64				
ODAM	54959	broad.mit.edu	37	4	71068501	71068501	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr4:71068501A>G	uc003hfc.2	+	9	694	c.677A>G	c.(676-678)CAA>CGA	p.Q226R		NM_017855	NP_060325	A1E959	ODAM_HUMAN	odontogenic ameloblast-associated protein	226					biomineral tissue development|odontogenesis of dentine-containing tooth	fibril				ovary(3)|large_intestine(1)	4						CCATATTTACAAAAAGAAGCG	0.388		NaN											0	0	0	0.00308	0	7	13				
GRSF1	2926	broad.mit.edu	37	4	71693625	71693625	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr4:71693625T>C	uc010iia.1	-	6	1162	c.1079A>G	c.(1078-1080)CAT>CGT	p.H360R	GRSF1_uc011caz.1_Missense_Mutation_p.H242R|GRSF1_uc003hfs.2_Missense_Mutation_p.H198R	NM_002092	NP_002083	Q12849	GRSF1_HUMAN	G-rich RNA sequence binding factor 1 isoform 1	360					mRNA polyadenylation		mRNA binding|nucleotide binding				0		all_hematologic(202;0.21)	Lung(101;0.235)			ATTTACTTCATGTTCTTCAAA	0.383		NaN											0	0	0	0.002299	0	19	50				
WDFY3	23001	broad.mit.edu	37	4	85731400	85731400	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr4:85731400T>C	uc003hpd.2	-	14	2393	c.1985A>G	c.(1984-1986)GAA>GGA	p.E662G	WDFY3_uc003hpf.2_Missense_Mutation_p.E662G	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	662						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		CAAAGATCTTTCCATAGCAAC	0.458		NaN											0	0	0	0.001368	0	10	29				
ANKRD50	57182	broad.mit.edu	37	4	125590169	125590169	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr4:125590169G>C	uc003ifg.3	-	3	4529	c.4263C>G	c.(4261-4263)TTC>TTG	p.F1421L	ANKRD50_uc011cgo.1_Missense_Mutation_p.F1242L|ANKRD50_uc010inw.2_Missense_Mutation_p.F1421L	NM_020337	NP_065070	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	1421										central_nervous_system(1)	1						TTTTATAGTTGAAGCTAGGGT	0.318		NaN											0	0	0	0.009096	0	4	4				
PCDH18	54510	broad.mit.edu	37	4	138452651	138452651	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr4:138452651G>A	uc003ihe.3	-	1	979	c.592C>T	c.(592-594)CTC>TTC	p.L198F	PCDH18_uc003ihf.3_Missense_Mutation_p.L191F|PCDH18_uc011cgz.1_Intron|PCDH18_uc003ihg.3_5'UTR|PCDH18_uc011cha.1_Intron	NM_019035	NP_061908	Q9HCL0	PCD18_HUMAN	protocadherin 18 precursor	198	Extracellular (Potential).|Cadherin 2.				brain development|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			pancreas(3)|skin(2)	5	all_hematologic(180;0.24)					ACCACTATGAGTTCTGCATAC	0.488		NaN											0	0	0	0.00308	0	8	30				
FNIP2	57600	broad.mit.edu	37	4	159789770	159789770	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr4:159789770G>T	uc003iqe.3	+	13	2165	c.1982G>T	c.(1981-1983)GGC>GTC	p.G661V		NM_020840	NP_065891	Q9P278	FNIP2_HUMAN	folliculin interacting protein 2	661	Interaction with PRKAA1.				DNA damage response, signal transduction resulting in induction of apoptosis|protein phosphorylation|regulation of protein phosphorylation	cytoplasm	protein binding				0	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.00936)		CCGCAAGATGGCTCTTCAAGA	0.522		NaN											1	0	1.49906e-05	0.00245	1.53851e-05	14	13				
FSTL5	56884	broad.mit.edu	37	4	162697123	162697123	+	Silent	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr4:162697123G>A	uc003iqh.2	-	5	949	c.513C>T	c.(511-513)GAC>GAT	p.D171D	FSTL5_uc003iqi.2_Silent_p.D170D|FSTL5_uc010iqv.2_Silent_p.D170D	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	171						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		GAGATATGTCGTCGCCATTAG	0.303		NaN											0	0	0	0.000602	0	5	9				
ANP32C	23520	broad.mit.edu	37	4	165118190	165118191	+	Missense_Mutation	DNP	CC	CC	AG			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr4:165118190_165118191CC>AG	uc011cjk.1	-	1	673_674	c.673_674GG>CT	c.(673-675)GGT>CTT	p.G225L	MARCH1_uc003iqs.1_Intron	NM_012403	NP_036535	O43423	AN32C_HUMAN	acidic nuclear phosphoprotein 32C	225	Asp/Glu-rich (highly acidic).										0	all_hematologic(180;0.203)	Prostate(90;0.0138)|Melanoma(52;0.18)|all_neural(102;0.223)		KIRC - Kidney renal clear cell carcinoma(143;0.242)		ttcttcttcaccaagctcttct	0.035		NaN											0	0	0	0.004672	0	8	6				
PDZD2	23037	broad.mit.edu	37	5	32048677	32048677	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr5:32048677T>C	uc003jhl.2	+	8	1940	c.1552T>C	c.(1552-1554)TAT>CAT	p.Y518H	PDZD2_uc003jhm.2_Missense_Mutation_p.Y518H|PDZD2_uc011cnx.1_Missense_Mutation_p.Y344H	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	518					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						AGTTGAAGAATATAACGAGCT	0.527		NaN											0	0	0	0.00361	0	51	46				
PDZD2	23037	broad.mit.edu	37	5	32089375	32089375	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr5:32089375G>T	uc003jhl.2	+	20	6209	c.5821G>T	c.(5821-5823)GAG>TAG	p.E1941*	PDZD2_uc003jhm.2_Nonsense_Mutation_p.E1941*	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	1941					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						AGCCGACCACGAGGACCCTGA	0.602		NaN											1	0	1.26289e-39	0.00361	1.44861e-39	96	88				
SPEF2	79925	broad.mit.edu	37	5	35779431	35779431	+	Nonsense_Mutation	SNP	T	T	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr5:35779431T>G	uc003jjo.2	+	30	4541	c.4430T>G	c.(4429-4431)TTA>TGA	p.L1477*	SPEF2_uc003jjp.1_Nonsense_Mutation_p.L963*|SPEF2_uc003jjr.2_5'UTR	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	1477					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GATCAGTTCTTAGATATGGCA	0.398		NaN											0	0	0	0.004878	0	31	26				
C7	730	broad.mit.edu	37	5	40972587	40972587	+	Silent	SNP	G	G	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr5:40972587G>C	uc003jmh.2	+	15	2079	c.1965G>C	c.(1963-1965)GTG>GTC	p.V655V	C7_uc011cpn.1_RNA	NM_000587	NP_000578	P10643	CO7_HUMAN	complement component 7 precursor	655	Sushi 2.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis	extracellular region|membrane attack complex					0		Ovarian(839;0.0112)				GTGAGAAGGTGACTGTTTCCT	0.473		NaN											0	0	0	0.00308	0	7	70				
HEATR7B2	133558	broad.mit.edu	37	5	41045898	41045898	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr5:41045898G>C	uc003jmj.3	-	18	2276	c.1786C>G	c.(1786-1788)CAG>GAG	p.Q596E	HEATR7B2_uc003jmi.3_Missense_Mutation_p.Q151E	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	596	HEAT 7.						binding			ovary(6)|central_nervous_system(2)	8						TTGAAATCCTGAGTCAGCTGA	0.388		NaN											0	0	0	0.00361	0	112	93				
MGC42105	167359	broad.mit.edu	37	5	43277375	43277375	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr5:43277375A>T	uc003jno.2	+	3	1390	c.509A>T	c.(508-510)GAA>GTA	p.E170V		NM_153361	NP_699192	Q8IY84	NIM1_HUMAN	serine/threonine-protein kinase NIM1	170	Protein kinase.						ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(4)|ovary(2)|stomach(1)|large_intestine(1)|breast(1)	9						AAGCTCTCTGAACCAGAAAGC	0.532		NaN											0	0	0	0.00623	0	29	77				
F2RL1	2150	broad.mit.edu	37	5	76129480	76129480	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr5:76129480G>C	uc003keo.2	+	2	1223	c.1048G>C	c.(1048-1050)GAT>CAT	p.D350H		NM_005242	NP_005233	P55085	PAR2_HUMAN	coagulation factor II (thrombin) receptor-like 1	350	Cytoplasmic (Potential).				blood coagulation|elevation of cytosolic calcium ion concentration|positive regulation of leukocyte chemotaxis|positive regulation of positive chemotaxis|regulation of blood coagulation	Golgi apparatus|integral to plasma membrane	receptor binding|thrombin receptor activity			central_nervous_system(1)	1		all_lung(232;0.000414)|Lung NSC(167;0.0011)|Ovarian(174;0.0129)|Prostate(461;0.11)		OV - Ovarian serous cystadenocarcinoma(54;7.7e-51)|Epithelial(54;2.77e-45)|all cancers(79;3.47e-41)		TGTTTCACATGATTTCAGGGA	0.488		NaN											0	0	0	0.00361	0	129	53				
PJA2	9867	broad.mit.edu	37	5	108680459	108680459	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr5:108680459C>G	uc003kos.3	-	8	2046	c.1826G>C	c.(1825-1827)AGT>ACT	p.S609T		NM_014819	NP_055634	O43164	PJA2_HUMAN	praja 2, RING-H2 motif containing	609	Interaction with PRKAR1A, PRKAR2A and PRKAR2B.				long-term memory|regulation of protein kinase A signaling cascade	cell junction|endoplasmic reticulum membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	ligase activity|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|zinc ion binding			ovary(1)|skin(1)	2		all_cancers(142;4.4e-06)|all_epithelial(76;8.17e-08)|Prostate(80;0.00676)|Lung NSC(167;0.0436)|Ovarian(225;0.0443)|all_lung(232;0.053)|Colorectal(57;0.0946)|Breast(839;0.151)		OV - Ovarian serous cystadenocarcinoma(64;3.46e-10)|Epithelial(69;6.02e-09)|COAD - Colon adenocarcinoma(37;0.224)		GCTTTCCTTACTAGCTGGTGG	0.413		NaN											0	0	0	0.003755	0	26	22				
CHSY3	337876	broad.mit.edu	37	5	129520908	129520908	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr5:129520908G>A	uc003kvd.2	+	3	2073	c.2073G>A	c.(2071-2073)ATG>ATA	p.M691I		NM_175856	NP_787052	Q70JA7	CHSS3_HUMAN	chondroitin sulfate synthase 3	691	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(2)|pancreas(1)	3		all_cancers(142;0.0227)|Breast(839;0.198)|Prostate(80;0.215)|Lung NSC(810;0.239)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.136)		TGATCCCAATGAAGGGAGAGT	0.443		NaN											0	0	0	0.00245	0	15	5				
FNIP1	96459	broad.mit.edu	37	5	131008068	131008068	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr5:131008068T>C	uc003kvs.1	-	14	2211	c.2069A>G	c.(2068-2070)GAC>GGC	p.D690G	RAPGEF6_uc003kvp.1_Intron|FNIP1_uc003kvt.1_Missense_Mutation_p.D662G|FNIP1_uc010jdm.1_Missense_Mutation_p.D645G	NM_133372	NP_588613	Q8TF40	FNIP1_HUMAN	folliculin interacting protein 1 isoform 1	690					regulation of protein phosphorylation	cytoplasm	protein binding			pancreas(1)|skin(1)	2		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		TGCACATTTGTCTACTGGAAC	0.418		NaN											0	0	0	0.00361	0	75	38				
ARHGAP26	23092	broad.mit.edu	37	5	142513586	142513586	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr5:142513586C>G	uc011dbj.1	+	19	1788	c.1753C>G	c.(1753-1755)CGG>GGG	p.R585G	ARHGAP26_uc003lmt.2_Missense_Mutation_p.R585G|ARHGAP26_uc003lmw.2_Missense_Mutation_p.R585G	NM_015071	NP_055886	Q9UNA1	RHG26_HUMAN	GTPase regulator associated with the focal	585	Ser-rich.				actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	cytoskeletal adaptor activity|Rho GTPase activator activity|SH3 domain binding			ovary(1)	1		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCACCTGTCTCGGAAGAAGAG	0.537		NaN											0	0	0	0.00361	0	125	41				
FAT2	2196	broad.mit.edu	37	5	150947267	150947267	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr5:150947267T>A	uc003lue.3	-	1	1239	c.1226A>T	c.(1225-1227)AAT>ATT	p.N409I	GM2A_uc011dcs.1_Intron|FAT2_uc010jhx.1_Missense_Mutation_p.N409I	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	409	Extracellular (Potential).|Cadherin 3.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGTTCGAGCATTAAGTTTAAA	0.537		NaN											0	0	0	0.002445	0	30	9				
CNOT8	9337	broad.mit.edu	37	5	154250228	154250228	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr5:154250228A>G	uc003lvu.2	+	5	798	c.319A>G	c.(319-321)ATG>GTG	p.M107V	CNOT8_uc011ddf.1_Missense_Mutation_p.M1V|CNOT8_uc011ddg.1_Missense_Mutation_p.M1V|CNOT8_uc011ddh.1_Intron|CNOT8_uc003lvv.2_Missense_Mutation_p.M107V|CNOT8_uc010jig.2_Missense_Mutation_p.M1V|CNOT8_uc010jif.2_Missense_Mutation_p.M1V|CNOT8_uc003lvw.2_Missense_Mutation_p.M107V|CNOT8_uc011ddi.1_Missense_Mutation_p.M1V|CNOT8_uc011ddj.1_Intron	NM_004779	NP_004770	Q9UFF9	CNOT8_HUMAN	CCR4-NOT transcription complex, subunit 8	107					negative regulation of cell proliferation|nuclear-transcribed mRNA poly(A) tail shortening	cytosol|nucleus	nucleic acid binding|protein binding|sequence-specific DNA binding transcription factor activity				0	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			TAGAGAGGACATGTACTCCCA	0.398		NaN						Direct_reversal_of_damage					0	0	0	0.006122	0	16	7				
HIST1H2AG	8969	broad.mit.edu	37	6	27101228	27101228	+	Silent	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:27101228G>A	uc003niw.2	+	1	412	c.378G>A	c.(376-378)AAG>AAA	p.K126K	HIST1H2BJ_uc003niu.1_5'Flank|HIST1H2BJ_uc003niv.2_5'Flank	NM_021064	NP_066408	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ag	126					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding				0						GCCACCACAAGGCGAAGGGCA	0.522		NaN											0	0	0	0.004289	0	32	61				
TRIM31	11074	broad.mit.edu	37	6	30071549	30071549	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:30071549C>T	uc003npg.1	-	9	1152	c.1042G>A	c.(1042-1044)GGG>AGG	p.G348R	TRIM31_uc003npi.3_RNA	NM_007028	NP_008959	Q9BZY9	TRI31_HUMAN	tripartite motif protein 31	348						mitochondrion	ligase activity|zinc ion binding			lung(1)	1						TTTGGTGGCCCCGATGTAGTT	0.567		NaN											0	0	0	0.00361	0	42	128				
MDC1	9656	broad.mit.edu	37	6	30672554	30672554	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:30672554G>T	uc003nrg.3	-	10	4846	c.4406C>A	c.(4405-4407)CCT>CAT	p.P1469H	MDC1_uc003nrf.3_Intron|MDC1_uc011dmp.1_Missense_Mutation_p.P1076H	NM_014641	NP_055456	Q14676	MDC1_HUMAN	mediator of DNA-damage checkpoint 1	1469	Pro-rich.|Interaction with the PRKDC complex.				cell cycle|double-strand break repair via homologous recombination|intra-S DNA damage checkpoint	focal adhesion|nucleoplasm	FHA domain binding|protein C-terminus binding			breast(2)|ovary(1)|kidney(1)	4						CTGAGACGTAGGCTCAGGGGT	0.562		NaN						Other_conserved_DNA_damage_response_genes					1	0	4.21773e-46	0.00361	4.864e-46	81	108				
HLA-C	3107	broad.mit.edu	37	6	31239079	31239079	+	Silent	SNP	G	G	A	rs45558335		TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:31239079G>A	uc003nsy.2	-	3	397	c.390C>T	c.(388-390)GAC>GAT	p.D130D	HLA-C_uc011dnj.1_Silent_p.D102D|HLA-C_uc003nsx.2_Silent_p.D9D|HLA-C_uc003nsz.2_Silent_p.D130D|HLA-C_uc010jsl.2_Silent_p.D130D|HLA-C_uc003nta.2_Silent_p.D130D|HLA-C_uc003ntb.2_Intron|HLA-C_uc003ntc.1_Intron|HLA-B_uc010jsm.1_Intron|HLA-B_uc011dnk.1_Intron|HLA-C_uc011dnl.1_Silent_p.D9D|HLA-B_uc003ntf.2_Silent_p.D130D	NM_002117	NP_002108	Q9TNN7	1C05_HUMAN	major histocompatibility complex, class I, C	130	Extracellular (Potential).|Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex					0						GGAGGCGCCCGTCGGGCCCCA	0.741		NaN											0	0	0	0.00361	0	25	190				
NOTCH4	4855	broad.mit.edu	37	6	32169985	32169985	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:32169985G>T	uc003obb.2	-	21	3762	c.3623C>A	c.(3622-3624)CCA>CAA	p.P1208Q	NOTCH4_uc003oba.2_5'UTR|NOTCH4_uc011dpu.1_Intron|NOTCH4_uc011dpv.1_Intron	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1208	LNR 1.|Extracellular (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						CCAGGGGTCTGGGACTCCCAG	0.637		NaN											1	0	2.84431e-33	0.00361	3.22806e-33	79	114				
ITPR3	3710	broad.mit.edu	37	6	33623613	33623613	+	Silent	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:33623613T>C	uc011drk.1	+	3	450	c.231T>C	c.(229-231)ACT>ACC	p.T77T		NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	77	Cytoplasmic (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						CCAAGCAGACTAAGCAGGACA	0.572		NaN											0	0	0	0.00361	0	52	71				
STK38	11329	broad.mit.edu	37	6	36483157	36483157	+	Silent	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:36483157G>A	uc003omg.2	-	6	1215	c.627C>T	c.(625-627)ATC>ATT	p.I209I	STK38_uc003omh.2_Silent_p.I209I|STK38_uc003omi.2_Silent_p.I209I	NM_007271	NP_009202	Q15208	STK38_HUMAN	serine/threonine kinase 38	209	Protein kinase.				intracellular protein kinase cascade|negative regulation of MAP kinase activity	cytoplasm|MLL5-L complex	ATP binding|magnesium ion binding|mitogen-activated protein kinase kinase kinase binding|protein serine/threonine kinase activity			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	6						TGTCTCTGTGGATGAATCCAA	0.433		NaN											0	0	0	0.00623	0	32	36				
TAF8	129685	broad.mit.edu	37	6	42019188	42019188	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:42019188G>C	uc003ors.2	+	2	168	c.139G>C	c.(139-141)GAG>CAG	p.E47Q	CCND3_uc003orp.2_5'Flank|CCND3_uc011duk.1_5'Flank|CCND3_uc011dum.1_5'Flank|TAF8_uc003orr.2_Missense_Mutation_p.E47Q|TAF8_uc003ort.2_Missense_Mutation_p.E47Q|TAF8_uc003oru.1_Missense_Mutation_p.E47Q|TAF8_uc003orv.1_Missense_Mutation_p.E47Q|TAF8_uc011dun.1_5'UTR	NM_138572	NP_612639	Q7Z7C8	TAF8_HUMAN	TBP-associated factor 8	47	Histone-fold.				cell differentiation|maintenance of protein location in nucleus|positive regulation of transcription, DNA-dependent|regulation of fat cell differentiation|transcription, DNA-dependent	perinuclear region of cytoplasm|transcription factor TFIID complex	DNA binding|protein binding			ovary(1)	1	Colorectal(47;0.196)		STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|Epithelial(12;0.00179)			CTTGCTGACAGAGGCAGGGTT	0.537		NaN											0	0	0	0.002299	0	23	74				
CUL9	23113	broad.mit.edu	37	6	43156452	43156452	+	Silent	SNP	A	A	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:43156452A>C	uc003ouk.2	+	8	2254	c.2179A>C	c.(2179-2181)AGA>CGA	p.R727R	CUL9_uc003ouj.1_3'UTR|CUL9_uc003oul.2_Silent_p.R727R|CUL9_uc010jyk.2_5'UTR|CUL9_uc003oum.1_3'UTR	NM_015089	NP_055904	Q8IWT3	CUL9_HUMAN	p53-associated parkin-like cytoplasmic protein	727					ubiquitin-dependent protein catabolic process	cullin-RING ubiquitin ligase complex|cytoplasm	ATP binding|ubiquitin protein ligase binding|zinc ion binding			ovary(5)|lung(3)|skin(2)|breast(1)|central_nervous_system(1)	12						CAGATCGCTGAGGTTAGCATA	0.552		NaN											0	0	0	0.003214	0	34	67				
POLR1C	9533	broad.mit.edu	37	6	43488129	43488129	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:43488129G>A	uc003ovn.2	+	6	676	c.619G>A	c.(619-621)GAA>AAA	p.E207K	POLR1C_uc003ovo.1_Missense_Mutation_p.E207K	NM_203290	NP_976035	O15160	RPAC1_HUMAN	RNA polymerase I subunit isoform 1	207					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein dimerization activity				0	all_cancers(18;3.79e-05)|Lung NSC(15;0.00217)|all_lung(25;0.00536)		Colorectal(64;0.00245)|all cancers(41;0.00511)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0711)			GCCTGGCCAAGAAATTGACCT	0.562		NaN											0	0	0	0.007291	0	22	107				
POLH	5429	broad.mit.edu	37	6	43571701	43571701	+	Silent	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:43571701C>T	uc003ovq.3	+	7	1141	c.837C>T	c.(835-837)ACC>ACT	p.T279T	POLH_uc010jyu.2_Silent_p.T155T|POLH_uc011dvl.1_RNA|POLH_uc003ovr.3_Silent_p.T180T	NM_006502	NP_006493	Q9Y253	POLH_HUMAN	DNA-directed DNA polymerase eta	279					DNA replication|DNA synthesis involved in DNA repair|regulation of DNA repair|response to UV-C	cytoplasm|nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			breast(2)	2	all_cancers(18;1.89e-05)|Lung NSC(15;0.00161)|all_lung(25;0.004)		all cancers(41;0.000753)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|STAD - Stomach adenocarcinoma(11;0.0826)|OV - Ovarian serous cystadenocarcinoma(102;0.167)			GTGAACTGACCCAGTTCACTG	0.408		NaN						DNA_polymerases_(catalytic_subunits)	Xeroderma_Pigmentosum				0	0	0	0.007413	0	14	23				
IBTK	25998	broad.mit.edu	37	6	82936933	82936933	+	Silent	SNP	T	T	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:82936933T>G	uc003pjl.1	-	5	1157	c.630A>C	c.(628-630)GGA>GGC	p.G210G	IBTK_uc011dyv.1_Silent_p.G210G|IBTK_uc011dyw.1_Silent_p.G210G|IBTK_uc010kbi.1_5'UTR|IBTK_uc003pjm.2_Silent_p.G210G	NM_015525	NP_056340	Q9P2D0	IBTK_HUMAN	inhibitor of Bruton's tyrosine kinase	210	RCC1 2.				negative regulation of protein phosphorylation|release of sequestered calcium ion into cytosol	cytoplasm|membrane|nucleus	protein kinase binding|protein tyrosine kinase inhibitor activity			ovary(2)|central_nervous_system(2)	4		all_cancers(76;3.38e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.0037)		BRCA - Breast invasive adenocarcinoma(397;0.0901)		CATCTCCATGTCCTAATCGCC	0.378		NaN											0	0	0	0.002445	0	26	47				
MDN1	23195	broad.mit.edu	37	6	90353822	90353822	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:90353822A>G	uc003pnn.1	-	102	16809	c.16693T>C	c.(16693-16695)TAC>CAC	p.Y5565H		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	5565	VWFA.				protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		ATGATATAGTATGGGAATGGG	0.448		NaN											0	0	0	0.00245	0	12	46				
MDN1	23195	broad.mit.edu	37	6	90422326	90422326	+	Silent	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:90422326G>A	uc003pnn.1	-	48	7514	c.7398C>T	c.(7396-7398)AAC>AAT	p.N2466N		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	2466					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TGCTCATCCTGTTGAGACAAT	0.468		NaN											0	0	0	0.00361	0	41	52				
MAP3K7	6885	broad.mit.edu	37	6	91254347	91254347	+	Nonsense_Mutation	SNP	A	A	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:91254347A>C	uc003pnz.1	-	12	1377	c.1215T>G	c.(1213-1215)TAT>TAG	p.Y405*	MAP3K7_uc003poa.1_Nonsense_Mutation_p.Y405*|MAP3K7_uc003pob.1_Intron|MAP3K7_uc003poc.1_Intron	NM_145331	NP_663304	O43318	M3K7_HUMAN	mitogen-activated protein kinase kinase kinase 7	405					activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|histone H3 acetylation|I-kappaB phosphorylation|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytosol|endosome membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|stomach(1)	6		all_cancers(76;6.4e-08)|Acute lymphoblastic leukemia(125;1.43e-09)|Prostate(29;9.32e-09)|all_hematologic(105;3.69e-06)|all_epithelial(107;0.000187)|Ovarian(999;0.0164)		OV - Ovarian serous cystadenocarcinoma(136;2.05e-11)|all cancers(137;3.25e-11)|GBM - Glioblastoma multiforme(226;0.0416)|BRCA - Breast invasive adenocarcinoma(108;0.0429)		TAGGCTTGGAATAGGCTGCAA	0.388		NaN											0	0	0	0.006214	0	9	34				
AIM1	202	broad.mit.edu	37	6	107011686	107011686	+	Silent	SNP	T	T	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:107011686T>G	uc003prh.2	+	19	5449	c.4962T>G	c.(4960-4962)TCT>TCG	p.S1654S	AIM1_uc003pri.2_Silent_p.S458S	NM_001624	NP_001615	Q9Y4K1	AIM1_HUMAN	absent in melanoma 1	1654	Ricin B-type lectin.						sugar binding			breast(4)|ovary(2)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	9	Breast(9;0.0138)|all_epithelial(6;0.169)	all_cancers(87;4.67e-25)|all_epithelial(87;5.46e-21)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|Colorectal(196;3.46e-05)|all_lung(197;5.94e-05)|Lung NSC(302;7.26e-05)|Ovarian(999;0.00473)	Epithelial(6;0.00114)|all cancers(7;0.00726)|BRCA - Breast invasive adenocarcinoma(8;0.0114)|OV - Ovarian serous cystadenocarcinoma(5;0.0305)	all cancers(137;1.73e-50)|Epithelial(106;2.42e-48)|OV - Ovarian serous cystadenocarcinoma(136;1.51e-27)|BRCA - Breast invasive adenocarcinoma(108;0.00104)|GBM - Glioblastoma multiforme(226;0.00858)		TGGTAACATCTGGCTCCAAGC	0.493		NaN											0	0	0	0.002522	0	30	36				
SASH1	23328	broad.mit.edu	37	6	148865308	148865308	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:148865308C>A	uc003qme.1	+	18	3177	c.2702C>A	c.(2701-2703)TCT>TAT	p.S901Y	SASH1_uc011eeb.1_Missense_Mutation_p.S662Y|SASH1_uc003qmf.1_Missense_Mutation_p.S311Y	NM_015278	NP_056093	O94885	SASH1_HUMAN	SAM and SH3 domain containing 1	901							protein binding			central_nervous_system(1)	1		Ovarian(120;0.0169)		OV - Ovarian serous cystadenocarcinoma(155;5.63e-11)|GBM - Glioblastoma multiforme(68;0.0701)		AAGAGATTTTCTGAACCTCAG	0.537		NaN											1	0	4.65686e-17	0.003755	5.10945e-17	30	102				
CNKSR3	154043	broad.mit.edu	37	6	154762424	154762424	+	Splice_Site	SNP	A	A	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:154762424A>C	uc003qpy.2	-	4	1012	c.507_splice	c.e4+1	p.K169_splice		NM_173515	NP_775786	Q6P9H4	CNKR3_HUMAN	CNKSR family member 3						negative regulation of ERK1 and ERK2 cascade|negative regulation of peptidyl-serine phosphorylation|positive regulation of sodium ion transport	cytoplasm|membrane				ovary(2)|breast(1)|skin(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;5.03e-11)|BRCA - Breast invasive adenocarcinoma(81;0.00627)		CATACTACTGACCTTCTGGAC	0.373		NaN											0	0	0	0.001984	0	5	28				
EIF2AK1	27102	broad.mit.edu	37	7	6086641	6086641	+	Silent	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:6086641T>C	uc003spp.2	-	5	677	c.531A>G	c.(529-531)GGA>GGG	p.G177G	EIF2AK1_uc003spq.2_Silent_p.G177G|EIF2AK1_uc011jwm.1_Silent_p.G53G|EIF2AK1_uc003spr.1_5'Flank	NM_014413	NP_055228	Q9BQI3	E2AK1_HUMAN	eukaryotic translation initiation factor 2-alpha	177	ATP (By similarity).|Protein kinase.				negative regulation of hemoglobin biosynthetic process|negative regulation of translational initiation by iron|protein autophosphorylation|response to external stimulus|response to stress	cytoplasm	ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|heme binding|protein homodimerization activity			upper_aerodigestive_tract(1)|stomach(1)|lung(1)|central_nervous_system(1)	4		Ovarian(82;0.0423)		UCEC - Uterine corpus endometrioid carcinoma (126;0.106)|OV - Ovarian serous cystadenocarcinoma(56;5.22e-14)		CTCTTCCGTATCCACCTTTTC	0.328		NaN											0	0	0	0.009718	0	33	15				
AGR2	10551	broad.mit.edu	37	7	16834567	16834567	+	Silent	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:16834567T>C	uc003str.2	-	7	658	c.471A>G	c.(469-471)ACA>ACG	p.T157T		NM_006408	NP_006399	O95994	AGR2_HUMAN	anterior gradient 2 homolog precursor	157					mucus secretion	endoplasmic reticulum|extracellular region	protein binding				0	Lung NSC(10;0.0376)|all_lung(11;0.0855)			UCEC - Uterine corpus endometrioid carcinoma (126;0.184)		TACACAGAGCTGTATCTGCAG	0.378		NaN											0	0	0	0.004007	0	14	49				
C7orf25	79020	broad.mit.edu	37	7	42949751	42949751	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:42949751A>T	uc003thw.2	-	2	1213	c.749T>A	c.(748-750)CTG>CAG	p.L250Q	C7orf25_uc010kxq.2_Missense_Mutation_p.L250Q|C7orf25_uc003thx.3_Missense_Mutation_p.L308Q|C7orf25_uc010kxr.2_Missense_Mutation_p.L308Q	NM_024054	NP_076959	Q9BPX7	CG025_HUMAN	hypothetical protein LOC79020 b	250										skin(1)	1						AGTAATGTCCAGATTTACTCT	0.413		NaN											0	0	0	0.001882	0	18	51				
HECW1	23072	broad.mit.edu	37	7	43436489	43436489	+	Splice_Site	SNP	G	G	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:43436489G>C	uc003tid.1	+	7	1236	c.631_splice	c.e7+1	p.D211_splice	HECW1_uc011kbi.1_Splice_Site_p.D211_splice|HECW1_uc003tie.1_Splice_Site_p.D243_splice	NM_015052	NP_055867	Q76N89	HECW1_HUMAN	NEDD4-like ubiquitin-protein ligase 1						protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	ubiquitin-protein ligase activity			ovary(8)|lung(6)|breast(4)|skin(4)|pancreas(1)	23						TCTCTCTCAGGTATGTTTTGC	0.403		NaN											0	0	0	0.000978	0	10	31				
PKD1L1	168507	broad.mit.edu	37	7	47892757	47892757	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:47892757A>G	uc003tny.1	-	31	4928	c.4928T>C	c.(4927-4929)GTG>GCG	p.V1643A		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1643	Extracellular (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						ATAAATCTGCACAATTGACTC	0.388		NaN											0	0	0	0.005524	0	24	70				
GUSB	2990	broad.mit.edu	37	7	65439384	65439384	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:65439384A>C	uc003tun.2	-	8	1365	c.1289T>G	c.(1288-1290)ATG>AGG	p.M430R	GUSB_uc011kdt.1_Missense_Mutation_p.M284R	NM_000181	NP_000172	P08236	BGLR_HUMAN	glucuronidase, beta precursor	430					glycosaminoglycan catabolic process	lysosome	beta-glucuronidase activity|cation binding				0						CACTTCTTCCATCACCTGCAT	0.607		NaN											0	0	0	0.00361	0	126	183				
PION	54103	broad.mit.edu	37	7	77006665	77006665	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:77006665C>T	uc003ugf.2	-	9	698	c.619G>A	c.(619-621)GAG>AAG	p.E207K	PION_uc003ugg.1_5'UTR	NM_017439	NP_059135	A4D1B5	GSAP_HUMAN	pigeon homolog	207					beta-amyloid formation|regulation of proteolysis	trans-Golgi network	beta-amyloid binding			central_nervous_system(1)	1						ACGAAATCCTCAGCTATTCTG	0.323		NaN											0	0	0	0.010504	0	17	88				
ZKSCAN5	23660	broad.mit.edu	37	7	99129564	99129564	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:99129564A>C	uc003uqv.2	+	7	2336	c.2212A>C	c.(2212-2214)ACT>CCT	p.T738P	ZKSCAN5_uc010lfx.2_Missense_Mutation_p.T738P|ZKSCAN5_uc003uqw.2_Missense_Mutation_p.T738P|ZKSCAN5_uc003uqx.2_Missense_Mutation_p.T665P|ZKSCAN5_uc003uqy.2_Missense_Mutation_p.T474P	NM_145102	NP_659570	Q9Y2L8	ZKSC5_HUMAN	zinc finger with KRAB and SCAN domains 5	738	C2H2-type 10.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)					GCATTACAGAACTCATACAGC	0.398		NaN											0	0	0	0.003271	0	30	32				
CYP3A4	1576	broad.mit.edu	37	7	99375680	99375680	+	Missense_Mutation	SNP	T	T	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:99375680T>G	uc003urv.1	-	3	293	c.189A>C	c.(187-189)GAA>GAC	p.E63D	CYP3A4_uc003urw.1_Missense_Mutation_p.E63D|CYP3A4_uc011kiz.1_Missense_Mutation_p.E63D|CYP3A4_uc011kja.1_Intron|CYP3A4_uc011kjb.1_Intron	NM_017460	NP_059488	P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A,	63					alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			central_nervous_system(3)|ovary(1)	4	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	TTTTATGACATTCCATGTCAA	0.363		NaN											0	0	0	0.000978	0	11	18				
EPHB4	2050	broad.mit.edu	37	7	100417868	100417868	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:100417868G>C	uc003uwn.1	-	5	1350	c.859C>G	c.(859-861)CCA>GCA	p.P287A	EPHB4_uc003uwm.1_Missense_Mutation_p.P194A|EPHB4_uc010lhj.1_Missense_Mutation_p.P287A|EPHB4_uc011kkf.1_Missense_Mutation_p.P287A|EPHB4_uc011kkg.1_Intron|EPHB4_uc011kkh.1_Missense_Mutation_p.P287A	NM_004444	NP_004435	P54760	EPHB4_HUMAN	EPH receptor B4 precursor	287	Extracellular (Potential).|Cys-rich.				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(4)|stomach(3)|skin(3)|central_nervous_system(2)|ovary(2)|breast(1)	15	Lung NSC(181;0.041)|all_lung(186;0.0581)					GCTGGGCATGGCTGGCAGGAC	0.592		NaN											0	0	0	0.00361	0	164	335				
COG5	10466	broad.mit.edu	37	7	106921779	106921779	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:106921779G>A	uc003ved.2	-	14	2159	c.1634C>T	c.(1633-1635)ACC>ATC	p.T545I	COG5_uc003vec.2_Missense_Mutation_p.T545I|COG5_uc003vee.2_Missense_Mutation_p.T545I	NM_181733	NP_859422	Q9UP83	COG5_HUMAN	component of oligomeric golgi complex 5 isoform	545					intra-Golgi vesicle-mediated transport|protein transport	cytosol|Golgi membrane|Golgi transport complex|nucleus	protein binding			central_nervous_system(2)|skin(2)	4						TAACTGGATGGTCTTTGCCAC	0.299		NaN											0	0	0	0.010504	0	13	25				
PPP1R3A	5506	broad.mit.edu	37	7	113519130	113519130	+	Missense_Mutation	SNP	T	T	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:113519130T>G	uc010ljy.1	-	4	2048	c.2017A>C	c.(2017-2019)ACA>CCA	p.T673P		NM_002711	NP_002702	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory (inhibitor)	673					glycogen metabolic process	integral to membrane				lung(9)|ovary(9)|pancreas(7)|skin(6)|breast(2)|prostate(1)	34						ATATGCTCTGTTATGTTTGTC	0.378		NaN											0	0	0	0.00361	0	43	49				
KCND2	3751	broad.mit.edu	37	7	120381638	120381638	+	Silent	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:120381638T>C	uc003vjj.1	+	3	2294	c.1329T>C	c.(1327-1329)GCT>GCC	p.A443A		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	443	Cytoplasmic (Potential).				regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					GCGCAAATGCTTACATGCAGA	0.368		NaN											0	0	0	0.010504	0	14	24				
PLXNA4	91584	broad.mit.edu	37	7	131832748	131832748	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:131832748C>G	uc003vra.3	-	27	5004	c.4775G>C	c.(4774-4776)GGT>GCT	p.G1592A	PLXNA4_uc003vqz.3_5'Flank	NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1592	Cytoplasmic (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						CACCACGGAACCATCTGGCAC	0.507		NaN											0	0	0	0.001855	0	12	78				
UBN2	254048	broad.mit.edu	37	7	138978726	138978726	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:138978726C>A	uc011kqr.1	+	17	3993	c.3993C>A	c.(3991-3993)CAC>CAA	p.H1331Q		NM_173569	NP_775840	Q6ZU65	UBN2_HUMAN	ubinuclein 2	1331										ovary(1)|skin(1)	2						AAGCATTTCACGGTGAGAACG	0.433		NaN											1	0	2.23348e-06	0.004007	2.31441e-06	14	25				
KEL	3792	broad.mit.edu	37	7	142650920	142650920	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:142650920C>A	uc003wcb.2	-	9	1258	c.1048G>T	c.(1048-1050)GTG>TTG	p.V350L		NM_000420	NP_000411	P23276	KELL_HUMAN	Kell blood group, metallo-endopeptidase	350	Extracellular (Potential).				proteolysis|vasoconstriction	integral to membrane|plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(3)|central_nervous_system(1)	4	Melanoma(164;0.059)					ATCTCCTCCACCAGTTGTGAC	0.537		NaN											1	0	5.88774e-50	0.00361	6.8266e-50	109	199				
ZNF786	136051	broad.mit.edu	37	7	148769267	148769267	+	Silent	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:148769267G>A	uc003wfh.2	-	4	734	c.597C>T	c.(595-597)AAC>AAT	p.N199N	ZNF786_uc011kuk.1_Silent_p.N162N|ZNF786_uc003wfi.2_Silent_p.N113N	NM_152411	NP_689624	Q8N393	ZN786_HUMAN	zinc finger protein 786	199	C2H2-type 1; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|skin(1)	4	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CTAAATGGTTGTTCTCCCAAC	0.582		NaN											0	0	0	0.00245	0	9	22				
FGF20	26281	broad.mit.edu	37	8	16859521	16859521	+	Silent	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr8:16859521G>A	uc003wxc.1	-	1	154	c.21C>T	c.(19-21)GTC>GTT	p.V7V	FGF20_uc010lsv.1_RNA|FGF20_uc010lsw.1_Silent_p.V7V	NM_019851	NP_062825	Q9NP95	FGF20_HUMAN	fibroblast growth factor 20	7					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway	extracellular region|soluble fraction	growth factor activity			lung(1)	1				Colorectal(111;0.0511)|COAD - Colon adenocarcinoma(73;0.207)		GAAAGCCCCCGACTTCGGCTA	0.637		NaN											0	0	0	0.00308	0	6	3				
DPYSL2	1808	broad.mit.edu	37	8	26509890	26509890	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr8:26509890C>T	uc003xfb.1	+	12	1749	c.1399C>T	c.(1399-1401)CGC>TGC	p.R467C	DPYSL2_uc003xfa.2_Missense_Mutation_p.R572C|DPYSL2_uc010luk.1_RNA|DPYSL2_uc011lah.1_Missense_Mutation_p.R431C	NM_001386	NP_001377	Q16555	DPYL2_HUMAN	dihydropyrimidinase-like 2	467					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	dihydropyrimidinase activity|protein binding			large_intestine(1)	1		all_cancers(63;0.121)|Ovarian(32;2.68e-05)|all_epithelial(46;0.116)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0228)|Epithelial(17;3.33e-10)|Colorectal(74;0.183)		AGGCTCTGGACGCTACATTCC	0.522		NaN											0	0	0	0.010504	0	19	45				
PRKDC	5591	broad.mit.edu	37	8	48817520	48817520	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr8:48817520T>C	uc003xqi.2	-	26	3008	c.2951A>G	c.(2950-2952)TAT>TGT	p.Y984C	PRKDC_uc003xqj.2_Missense_Mutation_p.Y984C|PRKDC_uc011ldh.1_Missense_Mutation_p.Y984C	NM_006904	NP_008835	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic	984					cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			lung(12)|central_nervous_system(9)|ovary(6)|skin(4)|large_intestine(3)	34		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				TAGTGGCTCATACAGTTGCCT	0.358		NaN						NHEJ					0	0	0	0.00333	0	19	19				
MOS	4342	broad.mit.edu	37	8	57025641	57025641	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr8:57025641C>T	uc011leb.1	-	1	901	c.901G>A	c.(901-903)GCT>ACT	p.A301T		NM_005372	NP_005363	P00540	MOS_HUMAN	v-mos Moloney murine sarcoma viral oncogene	301	Protein kinase.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|ovary(1)|central_nervous_system(1)	4			Epithelial(17;0.00117)|all cancers(17;0.00879)			AAGACGGCAGCGGAGAGGGAC	0.692		NaN											0	0	0	0.005524	0	26	67				
C8orf45	157777	broad.mit.edu	37	8	67803255	67803255	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr8:67803255T>C	uc003xwz.3	+	10	1400	c.1229T>C	c.(1228-1230)ATA>ACA	p.I410T	C8orf45_uc011lev.1_Missense_Mutation_p.I410T|C8orf45_uc011lew.1_Missense_Mutation_p.I341T|C8orf45_uc011lex.1_Missense_Mutation_p.I168T|C8orf45_uc003xwy.3_Missense_Mutation_p.I410T	NM_173518	NP_775789	Q4G0Z9	CH045_HUMAN	minichromosome maintenance complex	410					DNA replication		ATP binding|DNA binding			ovary(1)	1	Breast(64;0.186)		Epithelial(68;0.00384)|OV - Ovarian serous cystadenocarcinoma(28;0.00913)|all cancers(69;0.0175)|BRCA - Breast invasive adenocarcinoma(89;0.206)			ATCTGCTTTATAGGAGACTTG	0.368		NaN											0	0	0	0.002299	0	17	12				
RIMS2	9699	broad.mit.edu	37	8	105263981	105263981	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr8:105263981C>T	uc003yls.2	+	28	4278	c.4037C>T	c.(4036-4038)CCT>CTT	p.P1346L	RIMS2_uc003ylp.2_Missense_Mutation_p.P1328L|RIMS2_uc003ylq.2_Missense_Mutation_p.P1142L|RIMS2_uc003ylr.2_Missense_Mutation_p.P1167L	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1390					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			ACCTTGGCCCCTCTGACAAGA	0.448		NaN								HNSCC(12;0.0054)			0	0	0	0.006214	0	7	64				
CSMD3	114788	broad.mit.edu	37	8	114290867	114290867	+	Silent	SNP	G	G	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr8:114290867G>C	uc003ynu.2	-	3	627	c.468C>G	c.(466-468)ACC>ACG	p.T156T	CSMD3_uc003ynt.2_Silent_p.T116T|CSMD3_uc011lhx.1_Silent_p.T156T|CSMD3_uc010mcx.1_Silent_p.T156T	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	156	Extracellular (Potential).|CUB 1.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CAAAATCACTGGTCAAACGTA	0.373		NaN								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.004007	0	11	41				
ANXA13	312	broad.mit.edu	37	8	124714886	124714886	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr8:124714886C>A	uc003yqu.2	-	3	255	c.182G>T	c.(181-183)GGC>GTC	p.G61V	ANXA13_uc003yqt.2_Missense_Mutation_p.G102V	NM_004306	NP_004297	P27216	ANX13_HUMAN	annexin A13 isoform a	61	Annexin 1.				cell differentiation	plasma membrane	calcium ion binding|calcium-dependent phospholipid binding			ovary(1)|pancreas(1)|skin(1)	3	Lung NSC(37;2.06e-11)|Ovarian(258;0.00579)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00288)			AATCACCTTGCCGTACGTTGC	0.507		NaN											1	0	1.26612e-14	0.003271	1.3821e-14	26	102				
JRK	8629	broad.mit.edu	37	8	143745928	143745928	+	Silent	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr8:143745928C>T	uc003ywo.2	-	3	2062	c.1548G>A	c.(1546-1548)CGG>CGA	p.R516R	JRK_uc003ywp.2_Silent_p.R516R|JRK_uc010mew.1_Missense_Mutation_p.G517E	NM_001077527	NP_001070995			jerky isoform b												0	all_cancers(97;3.96e-12)|all_epithelial(106;1.19e-08)|Lung NSC(106;0.000413)|all_lung(105;0.00106)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)	Acute lymphoblastic leukemia(644;2.31e-05)				CACGCAGCGCCCgcagctgcc	0.363		NaN											0	0	0	0.007413	0	15	27				
FBXL6	26233	broad.mit.edu	37	8	145579794	145579794	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr8:145579794G>T	uc003zcb.2	-	8	1331	c.1306C>A	c.(1306-1308)CAG>AAG	p.Q436K	C8ORFK29_uc011llb.1_5'Flank|C8ORFK29_uc010mfw.2_5'Flank|C8ORFK29_uc003zby.3_5'Flank|FBXL6_uc003zbz.2_Missense_Mutation_p.Q163K|FBXL6_uc003zca.2_Missense_Mutation_p.Q430K|FBXL6_uc010mfx.2_Missense_Mutation_p.Q197K|GPR172A_uc003zcc.1_5'Flank|GPR172A_uc003zcd.1_5'Flank|GPR172A_uc003zce.1_5'Flank|GPR172A_uc010mfy.1_5'Flank|GPR172A_uc003zcf.1_5'Flank|GPR172A_uc011llc.1_5'Flank	NM_012162	NP_036294	Q8N531	FBXL6_HUMAN	F-box and leucine-rich repeat protein 6 isoform	436	LRR 9.				proteolysis		ubiquitin-protein ligase activity			ovary(1)|lung(1)	2	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			CACCACTTCTGGGTCAAAAAG	0.592		NaN											1	0	1.53134e-21	0.00361	1.70193e-21	58	105				
INSL4	3641	broad.mit.edu	37	9	5231528	5231528	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:5231528C>T	uc003ziy.2	+	1	110	c.5C>T	c.(4-6)GCC>GTC	p.A2V		NM_002195	NP_002186	Q14641	INSL4_HUMAN	insulin-like 4 precursor	2					cell proliferation|cell-cell signaling|female pregnancy|multicellular organismal development|signal transduction	extracellular space|soluble fraction	hormone activity|insulin-like growth factor receptor binding				0	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.0201)|Lung(218;0.14)		TCCAGGATGGCCAGCCTGTTC	0.557		NaN											0	0	0	0.005524	0	28	31				
CNTFR	1271	broad.mit.edu	37	9	34557969	34557969	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:34557969C>A	uc003zup.1	-	5	614	c.333G>T	c.(331-333)GAG>GAT	p.E111D	CNTFR_uc003zuq.1_Missense_Mutation_p.E111D	NM_147164	NP_671693	P26992	CNTFR_HUMAN	ciliary neurotrophic factor receptor	111	Fibronectin type-III 1.				nervous system development	anchored to membrane|extrinsic to membrane|plasma membrane	ciliary neurotrophic factor receptor activity|receptor binding			ovary(3)|central_nervous_system(1)|skin(1)	5	all_epithelial(49;0.0899)		STAD - Stomach adenocarcinoma(86;0.212)	GBM - Glioblastoma multiforme(74;0.00494)		TGAGCACAGGCTCCCGCGGCG	0.627		NaN											1	0	2.97109e-61	0.00361	3.46359e-61	132	252				
FOXB2	442425	broad.mit.edu	37	9	79635344	79635344	+	Silent	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:79635344G>A	uc004ako.1	+	1	774	c.774G>A	c.(772-774)GCG>GCA	p.A258A		NM_001013735	NP_001013757	Q5VYV0	FOXB2_HUMAN	forkhead box B2	258	Poly-Ala.				brain development|embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0						ctgccgccgcggccgcGGCGT	0.453		NaN											0	0	0	0.00499	0	16	20				
SYK	6850	broad.mit.edu	37	9	93629433	93629433	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:93629433A>G	uc004aqz.2	+	7	1072	c.867A>G	c.(865-867)ATA>ATG	p.I289M	SYK_uc004aqy.2_Missense_Mutation_p.I289M|SYK_uc004ara.2_Intron|SYK_uc004arb.2_Intron|SYK_uc004arc.2_Missense_Mutation_p.I289M|SYK_uc011ltr.1_RNA|SYK_uc011lts.1_RNA|SYK_uc011ltt.1_RNA	NM_003177	NP_003168	P43405	KSYK_HUMAN	spleen tyrosine kinase isoform 1	289	Linker.				cell proliferation|integrin-mediated signaling pathway|interspecies interaction between organisms|leukocyte cell-cell adhesion|neutrophil chemotaxis|organ morphogenesis|platelet activation|protein complex assembly	cytosol|T cell receptor complex	ATP binding|integrin binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|skin(1)	5						CGGGTGGAATAATCTCAAGAA	0.463		NaN	T	ETV6|ITK	MDS|peripheral T-cell lymphoma								0	0	0	0.006999	0	33	38				
WNK2	65268	broad.mit.edu	37	9	96051184	96051184	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:96051184C>G	uc004ati.1	+	20	4259	c.4259C>G	c.(4258-4260)CCT>CGT	p.P1420R	WNK2_uc011lud.1_Missense_Mutation_p.P1383R|WNK2_uc004atj.2_Missense_Mutation_p.P1383R|WNK2_uc004atk.2_Missense_Mutation_p.P1020R|WNK2_uc004atl.1_5'UTR	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	1420					intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12						CCCCCAGCCCCTTTGGCCCCC	0.652		NaN											0	0	0	0.002299	0	20	13				
GRIN3A	116443	broad.mit.edu	37	9	104499615	104499615	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:104499615A>G	uc004bbp.1	-	1	1248	c.647T>C	c.(646-648)CTG>CCG	p.L216P	GRIN3A_uc004bbq.1_Missense_Mutation_p.L216P	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	216	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	TGGAATGTGCAGGACTAAGCT	0.627		NaN											0	0	0	0.00361	0	38	110				
ABCA1	19	broad.mit.edu	37	9	107593948	107593948	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:107593948C>T	uc004bcl.2	-	13	1983	c.1670G>A	c.(1669-1671)CGA>CAA	p.R557Q		NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	557	Extracellular.				Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	AATGTCCATTCGGATCTTGTA	0.488		NaN											0	0	0	0.001855	0	13	14				
ZNF462	58499	broad.mit.edu	37	9	109694734	109694734	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:109694734G>T	uc004bcz.2	+	5	6309	c.6020G>T	c.(6019-6021)CGT>CTT	p.R2007L	ZNF462_uc010mto.2_Missense_Mutation_p.R1916L|ZNF462_uc004bda.2_Missense_Mutation_p.R1915L|ZNF462_uc011lvz.1_5'Flank	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	2007					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						CAGGGGCTGCGTTCTCATGAG	0.537		NaN											1	0	6.44725e-10	0.002299	6.79575e-10	20	59				
C9orf152	401546	broad.mit.edu	37	9	112963549	112963549	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:112963549G>T	uc011lwk.1	-	2	953	c.399C>A	c.(397-399)GAC>GAA	p.D133E		NM_001012993	NP_001013011	Q5JTZ5	CI152_HUMAN	hypothetical protein LOC401546	133											0						GATGACTGGTGTCCTGGGGGG	0.557		NaN											1	0	2.51541e-25	0.004878	2.8249e-25	31	129				
TNC	3371	broad.mit.edu	37	9	117846585	117846585	+	Silent	SNP	G	G	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:117846585G>T	uc004bjj.3	-	4	2396	c.2034C>A	c.(2032-2034)ATC>ATA	p.I678I	TNC_uc010mvf.2_Silent_p.I678I	NM_002160	NP_002151	P24821	TENA_HUMAN	tenascin C precursor	678	Fibronectin type-III 1.				cell adhesion|response to wounding|signal transduction	extracellular space	receptor binding|syndecan binding			central_nervous_system(4)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	7						GCTCCTGGATGATGGTGGACG	0.572		NaN											1	0	3.41278e-10	0.00499	3.62397e-10	14	43				
MEGF9	1955	broad.mit.edu	37	9	123421791	123421791	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:123421791C>T	uc004bkj.1	-	4	775	c.775G>A	c.(775-777)GGG>AGG	p.G259R	MEGF9_uc011lyb.1_Missense_Mutation_p.G214R|MEGF9_uc004bkk.3_Missense_Mutation_p.G214R	NM_001080497	NP_001073966	Q9H1U4	MEGF9_HUMAN	multiple EGF-like-domains 9	222	Laminin EGF-like 1.|Extracellular (Potential).					integral to membrane	calcium ion binding				0						TCACACTGCCCTGTGGTCTGG	0.478		NaN											0	0	0	0.006214	0	8	11				
FAM129B	64855	broad.mit.edu	37	9	130280165	130280165	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:130280165C>T	uc004brh.2	-	6	847	c.645G>A	c.(643-645)ATG>ATA	p.M215I	FAM129B_uc004bri.2_Missense_Mutation_p.M202I|FAM129B_uc004brj.3_Missense_Mutation_p.M215I	NM_022833	NP_073744	Q96TA1	NIBL1_HUMAN	hypothetical protein LOC64855 isoform 1	215							protein binding				0						ACTGTCGGTACATGCGGATGG	0.612		NaN											0	0	0	0.005443	0	21	30				
CLIC3	9022	broad.mit.edu	37	9	139890163	139890163	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:139890163C>G	uc004ckj.1	-	2	109	c.80G>C	c.(79-81)CGG>CCG	p.R27P		NM_004669	NP_004660	O95833	CLIC3_HUMAN	chloride intracellular channel 3	27	Required for insertion into the membrane (By similarity).|Helical; (Potential).|GST N-terminal.				signal transduction	chloride channel complex|cytoplasm|nucleus	protein binding|voltage-gated chloride channel activity				0	all_cancers(76;0.11)	Myeloproliferative disorder(178;0.0511)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;2.94e-05)|Epithelial(140;0.00048)		CATGAAGAGCCGCTGGCAGGA	0.697		NaN											0	0	0	0.00245	0	11	31				
GRIN1	2902	broad.mit.edu	37	9	140052946	140052946	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:140052946G>T	uc004clk.2	+	7	1414	c.1084G>T	c.(1084-1086)GTG>TTG	p.V362L	GRIN1_uc004cli.1_Missense_Mutation_p.V37L|GRIN1_uc004clj.1_Missense_Mutation_p.V359L|GRIN1_uc004cll.2_Missense_Mutation_p.V362L|GRIN1_uc004clm.2_Missense_Mutation_p.V362L|GRIN1_uc004cln.2_Missense_Mutation_p.V380L|GRIN1_uc004clo.2_Missense_Mutation_p.V380L	NM_007327	NP_015566	Q05586	NMDZ1_HUMAN	NMDA receptor 1 isoform NR1-3 precursor	362	Extracellular (Potential).				ionotropic glutamate receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of excitatory postsynaptic membrane potential|response to ethanol|visual learning	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane|synaptic vesicle|synaptosome	calcium ion binding|calmodulin binding|extracellular-glutamate-gated ion channel activity|glutamate binding|glycine binding			skin(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;6.87e-05)|Epithelial(140;0.00095)	L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	CCGCAAGCTGGTGCAAGTGGG	0.617		NaN											1	0	1.16021e-09	0.007291	1.21992e-09	25	80				
SSNA1	8636	broad.mit.edu	37	9	140083594	140083594	+	Silent	SNP	G	G	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:140083594G>A	uc004cls.2	+	2	254	c.129G>A	c.(127-129)CTG>CTA	p.L43L	ANAPC2_uc004clq.1_5'Flank|ANAPC2_uc004clr.1_5'Flank|ANAPC2_uc011mer.1_5'Flank	NM_003731	NP_003722	O43805	SSNA1_HUMAN	nuclear autoantigen of 14 kDa	43	Potential.				G2/M transition of mitotic cell cycle	centrosome|cytosol|nucleus				breast(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0698)	OV - Ovarian serous cystadenocarcinoma(145;6.43e-05)|Epithelial(140;0.00087)		AGCAGCGGCTGCAGAATGAGG	0.657		NaN											0	0	0	0.00333	0	23	30				
ARRDC1	92714	broad.mit.edu	37	9	140508609	140508609	+	Silent	SNP	C	C	G	rs145510266		TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:140508609C>G	uc004cns.2	+	5	635	c.561C>G	c.(559-561)GCC>GCG	p.A187A	ARRDC1_uc004cnt.2_Silent_p.A62A|ARRDC1_uc004cnu.2_RNA|ARRDC1_uc004cnv.2_Silent_p.A167A|ARRDC1_uc004cnw.2_Silent_p.A62A|ARRDC1_uc004cnp.1_Silent_p.A187A|ARRDC1_uc004cnq.1_Silent_p.A169A|ARRDC1_uc011mfb.1_Silent_p.A62A|ARRDC1_uc004cnx.1_Silent_p.A62A|ARRDC1_uc004cny.2_RNA	NM_152285	NP_689498	Q8N5I2	ARRD1_HUMAN	arrestin domain containing 1	187											0	all_cancers(76;0.106)			OV - Ovarian serous cystadenocarcinoma(145;0.000273)|Epithelial(140;0.000464)		AGCTGCATGCCGACGTTGAGA	0.642		NaN											0	0	0	0.00361	0	340	356				
FANCB	2187	broad.mit.edu	37	X	14863348	14863348	+	Silent	SNP	C	C	A			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chrX:14863348C>A	uc004cwg.1	-	8	1825	c.1557G>T	c.(1555-1557)CGG>CGT	p.R519R	FANCB_uc004cwh.1_Silent_p.R519R	NM_001018113	NP_001018123	Q8NB91	FANCB_HUMAN	Fanconi anemia complementation group B	519					DNA repair	nucleoplasm				lung(1)	1	Hepatocellular(33;0.183)					ACTTTAGAAGCCGAAATCTGG	0.388		NaN						Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				1	0	4.35082e-09	0.010504	4.56357e-09	19	6				
KDM6A	7403	broad.mit.edu	37	X	44922670	44922670	+	Nonsense_Mutation	SNP	A	A	T			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08			A	T	A	A		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chrX:44922670A>T	uc004dge.3	+	16	1906	c.1531A>T	c.(1531-1533)AGA>TGA	p.R511*	KDM6A_uc010nhk.2_Nonsense_Mutation_p.R477*|KDM6A_uc011mkz.1_Nonsense_Mutation_p.R563*|KDM6A_uc011mla.1_Nonsense_Mutation_p.R466*|KDM6A_uc011mlb.1_Nonsense_Mutation_p.R518*|KDM6A_uc011mlc.1_Nonsense_Mutation_p.R215*|KDM6A_uc011mld.1_Nonsense_Mutation_p.R150*	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	511					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						TTGACAGATGAGACCAACAGG	0.433		NaN	D|N|F|S		renal|oesophageal SCC|MM								0	0	0	0.00361	0	42	8		Valid		
AKAP4	8852	broad.mit.edu	37	X	49957631	49957631	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chrX:49957631A>C	uc004dow.1	-	5	1857	c.1733T>G	c.(1732-1734)ATG>AGG	p.M578R	AKAP4_uc004dov.1_Missense_Mutation_p.M195R|AKAP4_uc010njp.1_Missense_Mutation_p.M400R|AKAP4_uc004dou.1_Missense_Mutation_p.M569R	NM_003886	NP_003877	Q5JQC9	AKAP4_HUMAN	A-kinase anchor protein 4 isoform 1	578					cell projection organization|single fertilization|sperm motility	cAMP-dependent protein kinase complex|cilium|cytoskeleton|microtubule-based flagellum	protein kinase A binding			kidney(3)|central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	8	Ovarian(276;0.236)					ACTCTGAGCCATATAGCCCAT	0.483		NaN											0	0	0	0.004007	0	16	8				
MAP3K6	9064	broad.mit.edu	37	1	27683217	27683233	+	Frame_Shift_Del	DEL	GTGAGACCGCCTCCTTC	GTGAGACCGCCTCCTTC	-			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:27683217_27683233delGTGAGACCGCCTCCTTC	uc001bny.1	-	25	3621_3637	c.3372_3388delGAAGGAGGCGGTCTCAC	c.(3370-3390)GAGAAGGAGGCGGTCTCACCGfs	p.E1124fs	MAP3K6_uc009vsw.1_Frame_Shift_Del_p.E1116fs	NM_004672	NP_004663	O95382	M3K6_HUMAN	mitogen-activated protein kinase kinase kinase	1124_1130					activation of JUN kinase activity		ATP binding|magnesium ion binding|MAP kinase kinase kinase activity			breast(4)|lung(3)|ovary(1)|central_nervous_system(1)	9		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0416)|OV - Ovarian serous cystadenocarcinoma(117;1.69e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00132)|KIRC - Kidney renal clear cell carcinoma(1967;0.00163)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		TCTGACCTCGGTGAGACCGCCTCCTTCTCCACCTCTG	0.664		NaN											NaN	NaN	NaN	NaN	NaN	7	64	---		---	---
TCHH	7062	broad.mit.edu	37	1	152082957	152082959	+	In_Frame_Del	DEL	CTC	CTC	-	rs143222885	by1000genomes	TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr1:152082957_152082959delCTC	uc001ezp.2	-	2	2734_2736	c.2734_2736delGAG	c.(2734-2736)GAGdel	p.E912del	TCHH_uc009wne.1_In_Frame_Del_p.E912del	NM_007113	NP_009044	Q07283	TRHY_HUMAN	trichohyalin	912	4-1.|10 X 30 AA tandem repeats.				keratinization	cytoskeleton	calcium ion binding			ovary(3)|kidney(1)|central_nervous_system(1)	5	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CTCTCTGTAGCTCCTCCTCCTCC	0.586		NaN											NaN	NaN	NaN	NaN	NaN	10	170	---		---	---
IFIT2	3433	broad.mit.edu	37	10	91065822	91065822	+	Frame_Shift_Del	DEL	A	A	-			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr10:91065822delA	uc009xts.2	+	2	284	c.109delA	c.(109-111)AAAfs	p.K37fs	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron|uc001kgd.2_Intron	NM_001547	NP_001538	P09913	IFIT2_HUMAN	interferon-induced protein with	37					negative regulation of protein binding|response to virus|type I interferon-mediated signaling pathway		protein binding			ovary(1)|skin(1)	2		Colorectal(252;0.0161)				TTTTGAAGACAAAGTATTTTA	0.438		NaN											NaN	NaN	NaN	NaN	NaN	22	13	---		---	---
LRFN4	78999	broad.mit.edu	37	11	66625231	66625233	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr11:66625231_66625233delCTG	uc001ojr.2	+	1	356_358	c.16_18delCTG	c.(16-18)CTGdel	p.L10del	PC_uc001ojo.1_Intron|PC_uc001ojp.1_Intron|PC_uc001ojn.1_Intron|LRFN4_uc001ojq.1_In_Frame_Del_p.L10del|LRFN4_uc001ojs.2_In_Frame_Del_p.L10del	NM_024036	NP_076941	Q6PJG9	LRFN4_HUMAN	leucine rich repeat and fibronectin type III	10						integral to membrane					0						CCCGCCGCTCCTGCTGCTGCTGC	0.719		NaN											NaN	NaN	NaN	NaN	NaN	7	110	---		---	---
IFFO1	25900	broad.mit.edu	37	12	6649704	6649706	+	In_Frame_Del	DEL	GGC	GGC	-	rs144019095		TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr12:6649704_6649706delGGC	uc001qpd.1	-	9	1657_1659	c.1623_1625delGCC	c.(1621-1626)CCGCCA>CCA	p.541_542PP>P	IFFO1_uc001qoy.2_RNA|IFFO1_uc001qpa.1_In_Frame_Del_p.181_182PP>P|IFFO1_uc001qpb.1_In_Frame_Del_p.218_219PP>P|IFFO1_uc001qpe.1_RNA|IFFO1_uc010sfe.1_In_Frame_Del_p.553_554PP>P|IFFO1_uc001qpf.1_In_Frame_Del_p.544_545PP>P|IFFO1_uc001qoz.1_In_Frame_Del_p.182_183PP>P|IFFO1_uc001qpc.1_In_Frame_Del_p.545_546PP>P|IFFO1_uc001qpg.2_In_Frame_Del_p.R181del	NM_080730	NP_542768	Q0D2I5	IFFO1_HUMAN	intermediate filament family orphan isoform 2	541_542	Poly-Pro.					intermediate filament					0						AGCCTCGCTTGGCGGCGGCGGCG	0.601		NaN											NaN	NaN	NaN	NaN	NaN	14	188	---		---	---
CLDN10	9071	broad.mit.edu	37	13	96205153	96205168	+	Frame_Shift_Del	DEL	TGTGGAAGGCGTGCGT	TGTGGAAGGCGTGCGT	-			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr13:96205153_96205168delTGTGGAAGGCGTGCGT	uc001vmh.2	+	1	207_222	c.146_161delTGTGGAAGGCGTGCGT	c.(145-162)CTGTGGAAGGCGTGCGTTfs	p.L49fs	CLDN10_uc001vmg.2_Intron|CLDN10_uc010tii.1_Intron	NM_006984	NP_008915	P78369	CLD10_HUMAN	claudin 10 isoform b	49_54	Extracellular (Potential).				calcium-independent cell-cell adhesion	integral to membrane|tight junction	identical protein binding|structural molecule activity			ovary(1)	1	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.18)			TGGGCCAACCTGTGGAAGGCGTGCGTTACCGACTCC	0.644		NaN											NaN	NaN	NaN	NaN	NaN	24	210	---		---	---
FAM155A	728215	broad.mit.edu	37	13	108518687	108518689	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr13:108518687_108518689delCTG	uc001vql.2	-	1	772_774	c.256_258delCAG	c.(256-258)CAGdel	p.Q86del		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	86	Poly-Gln.					integral to membrane	binding			skin(1)	1						gccgctgcctctgctgctgctgc	0.404		NaN											NaN	NaN	NaN	NaN	NaN	8	85	---		---	---
CHRNA3	1136	broad.mit.edu	37	15	78913068	78913070	+	In_Frame_Del	DEL	CAG	CAG	-	rs66793222		TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr15:78913068_78913070delCAG	uc002bec.2	-	1	253_255	c.67_69delCTG	c.(67-69)CTGdel	p.L23del	CHRNA3_uc002bea.2_RNA|CHRNA3_uc002beb.2_In_Frame_Del_p.L23del	NM_000743	NP_000734	P32297	ACHA3_HUMAN	cholinergic receptor, nicotinic, alpha 3	23			Missing.		activation of transmembrane receptor protein tyrosine kinase activity|behavioral response to nicotine|locomotory behavior|regulation of acetylcholine secretion|regulation of dendrite morphogenesis|regulation of excitatory postsynaptic membrane potential|regulation of smooth muscle contraction|synaptic transmission involved in micturition|synaptic transmission, cholinergic	cell junction|dendrite|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic density|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(3)|ovary(1)	4						gcagcagagacagcagcagcagc	0.601		NaN											NaN	NaN	NaN	NaN	NaN	4	5	---		---	---
ZNF598	90850	broad.mit.edu	37	16	2049883	2049885	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:2049883_2049885delTCC	uc002cof.1	-	11	1680_1682	c.1665_1667delGGA	c.(1663-1668)GAGGAC>GAC	p.E555del	ZNF598_uc002coe.1_5'UTR	NM_178167	NP_835461	Q86UK7	ZN598_HUMAN	zinc finger protein 598	555						intracellular	zinc ion binding			lung(1)|breast(1)	2						CGGGCCGCCGTCCTCCTCCTCCT	0.709		NaN											NaN	NaN	NaN	NaN	NaN	4	6	---		---	---
ABCA3	21	broad.mit.edu	37	16	2369649	2369651	+	In_Frame_Del	DEL	AGC	AGC	-	rs145342500		TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:2369649_2369651delAGC	uc002cpy.1	-	8	1516_1518	c.804_806delGCT	c.(802-807)CTGCTC>CTC	p.268_269LL>L	ABCA3_uc010bsk.1_In_Frame_Del_p.268_269LL>L|ABCA3_uc010bsl.1_In_Frame_Del_p.268_269LL>L	NM_001089	NP_001080	Q99758	ABCA3_HUMAN	ATP-binding cassette, sub-family A member 3	268_269	Helical; (Potential).				response to drug	integral to membrane|lamellar body|membrane fraction|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(5)|ovary(5)|central_nervous_system(3)|upper_aerodigestive_tract(1)|lung(1)|skin(1)	16		Ovarian(90;0.17)				GGTGAAGCTGAGCAGCAGCAGCA	0.611		NaN											NaN	NaN	NaN	NaN	NaN	9	367	---		---	---
IL27	246778	broad.mit.edu	37	16	28518125	28518126	+	Frame_Shift_Ins	INS	-	-	C			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:28518125_28518126insC	uc002dqc.2	-	1	30_31	c.7_8insG	c.(7-9)CAGfs	p.Q3fs	uc010vct.1_Intron	NM_145659	NP_663634	Q8NEV9	IL27A_HUMAN	interleukin 27 precursor	3					inflammatory response|innate immune response|positive regulation of interferon-gamma biosynthetic process|regulation of defense response to virus|regulation of T cell proliferation|regulation of T-helper 1 cell differentiation	extracellular space	cytokine activity|interleukin-27 receptor binding				0						GCCTGCCGTCTGGCCCATGGCG	0.629		NaN											NaN	NaN	NaN	NaN	NaN	40	119	---		---	---
SEPT1	1731	broad.mit.edu	37	16	30390387	30390388	+	Frame_Shift_Ins	INS	-	-	AGCG			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr16:30390387_30390388insAGCG	uc002dxy.2	-	10	1064_1065	c.877_878insCGCT	c.(877-879)TGCfs	p.C293fs	SEPT1_uc002dxw.2_5'Flank|SEPT1_uc002dxx.2_Frame_Shift_Ins_p.C118fs	NM_052838	NP_443070	Q8WYJ6	SEPT1_HUMAN	septin 1	293					cell cycle|cell division	microtubule organizing center|septin complex	GTP binding|protein binding			ovary(1)	1			Colorectal(24;0.193)			GCTCTGTAGGCAGCGGGCCCGG	0.658		NaN											NaN	NaN	NaN	NaN	NaN	65	108	---		---	---
NOTCH3	4854	broad.mit.edu	37	19	15290217	15290223	+	Frame_Shift_Del	DEL	GGTCAAT	GGTCAAT	-			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr19:15290217_15290223delGGTCAAT	uc002nan.2	-	21	3488_3494	c.3412_3418delATTGACC	c.(3412-3420)ATTGACCTCfs	p.I1138fs	NOTCH3_uc002nao.1_Frame_Shift_Del_p.I1086fs	NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	1138_1140	Extracellular (Potential).|EGF-like 29; calcium-binding (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			CGGGCCACGAGGTCAATGCATGAACCC	0.594		NaN											NaN	NaN	NaN	NaN	NaN	63	111	---		---	---
ESPNL	339768	broad.mit.edu	37	2	239039530	239039530	+	Frame_Shift_Del	DEL	G	G	-	rs115923307	by1000genomes	TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr2:239039530delG	uc002vxq.3	+	9	2285	c.2175delG	c.(2173-2175)GCGfs	p.A725fs	ESPNL_uc010fyw.2_Frame_Shift_Del_p.A421fs	NM_194312	NP_919288	Q6ZVH7	ESPNL_HUMAN	espin-like	725										pancreas(1)	1		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		CATCAGAGGCGGGTGCCGCAG	0.682		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---		---	---
LAMA5	3911	broad.mit.edu	37	20	60895697	60895698	+	Frame_Shift_Ins	INS	-	-	G	rs2297587	by1000genomes	TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr20:60895697_60895698insG	uc002ycq.2	-	50	6743_6744	c.6676_6677insC	c.(6676-6678)CGCfs	p.R2226fs		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	2226	Domain II and I.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CGTCTCATGGCGGGGGCCCAGG	0.708		NaN											NaN	NaN	NaN	NaN	NaN	10	55	---		---	---
PDE5A	8654	broad.mit.edu	37	4	120446823	120446823	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr4:120446823delG	uc003idh.2	-	12	1815	c.1660delC	c.(1660-1662)CTTfs	p.L554fs	uc003ide.3_Intron|PDE5A_uc003idf.2_Frame_Shift_Del_p.L512fs|PDE5A_uc003idg.2_Frame_Shift_Del_p.L502fs|uc003idi.3_Intron	NM_001083	NP_001074	O76074	PDE5A_HUMAN	phosphodiesterase 5A isoform 1	554					platelet activation|signal transduction	cytosol	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|zinc ion binding				0					Dipyridamole(DB00975)|Pentoxifylline(DB00806)|Sildenafil(DB00203)|Tadalafil(DB00820)|Theophylline(DB00277)|Vardenafil(DB00862)	GTAATTTTAAGGGTCTGGGCA	0.408		NaN											NaN	NaN	NaN	NaN	NaN	15	47	---		---	---
MAP3K7	6885	broad.mit.edu	37	6	91296568	91296570	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:91296568_91296570delGAG	uc003pnz.1	-	1	195_197	c.33_35delCTC	c.(31-36)TCCTCG>TCG	p.11_12SS>S	MAP3K7_uc003poa.1_In_Frame_Del_p.11_12SS>S|MAP3K7_uc003pob.1_In_Frame_Del_p.11_12SS>S|MAP3K7_uc003poc.1_In_Frame_Del_p.11_12SS>S	NM_145331	NP_663304	O43318	M3K7_HUMAN	mitogen-activated protein kinase kinase kinase 7	11_12	Poly-Ser.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|histone H3 acetylation|I-kappaB phosphorylation|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of T cell cytokine production|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transforming growth factor beta receptor signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytosol|endosome membrane	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)|stomach(1)	6		all_cancers(76;6.4e-08)|Acute lymphoblastic leukemia(125;1.43e-09)|Prostate(29;9.32e-09)|all_hematologic(105;3.69e-06)|all_epithelial(107;0.000187)|Ovarian(999;0.0164)		OV - Ovarian serous cystadenocarcinoma(136;2.05e-11)|all cancers(137;3.25e-11)|GBM - Glioblastoma multiforme(226;0.0416)|BRCA - Breast invasive adenocarcinoma(108;0.0429)		GGCCGAAGACGAGGAGGAGGAGG	0.655		NaN											NaN	NaN	NaN	NaN	NaN	9	99	---		---	---
SMPD2	6610	broad.mit.edu	37	6	109765030	109765042	+	Frame_Shift_Del	DEL	GGCCCAGGATCTG	GGCCCAGGATCTG	-			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:109765030_109765042delGGCCCAGGATCTG	uc003pti.2	+	10	1588_1600	c.1194_1206delGGCCCAGGATCTG	c.(1192-1206)GAGGCCCAGGATCTGfs	p.E398fs		NM_003080	NP_003071	O60906	NSMA_HUMAN	sphingomyelin phosphodiesterase 2, neutral	398_402					induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|sphingomyelin metabolic process	integral to plasma membrane	metal ion binding|sphingomyelin phosphodiesterase activity				0		all_cancers(87;1.1e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000144)|all_lung(197;0.0221)|Colorectal(196;0.0488)|Lung SC(18;0.0548)		Epithelial(106;0.0137)|all cancers(137;0.0188)|OV - Ovarian serous cystadenocarcinoma(136;0.0228)|BRCA - Breast invasive adenocarcinoma(108;0.0566)		GGGCAAGGGAGGCCCAGGATCTGGGCCCAGAGC	0.568		NaN											NaN	NaN	NaN	NaN	NaN	9	72	---		---	---
GRM1	2911	broad.mit.edu	37	6	146755399	146755401	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:146755399_146755401delCAG	uc010khw.1	+	9	3522_3524	c.3052_3054delCAG	c.(3052-3054)CAGdel	p.Q1022del	GRM1_uc010khv.1_3'UTR|GRM1_uc003qll.2_3'UTR|GRM1_uc011edz.1_3'UTR|GRM1_uc011eea.1_3'UTR	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	1022	Gln/Pro-rich.|Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	CCCTCCTCTCCAGCAGCAGCAGC	0.66		NaN											NaN	NaN	NaN	NaN	NaN	11	471	---		---	---
EZR	7430	broad.mit.edu	37	6	159188477	159188477	+	Frame_Shift_Del	DEL	G	G	-	rs139613796		TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr6:159188477delG	uc003qrt.3	-	12	1627	c.1412delC	c.(1411-1413)CCGfs	p.P471fs	EZR_uc011efr.1_Frame_Shift_Del_p.P78fs|EZR_uc011efs.1_Frame_Shift_Del_p.P439fs|EZR_uc003qru.3_Frame_Shift_Del_p.P471fs	NM_003379	NP_003370	P15311	EZRI_HUMAN	ezrin	471	Interaction with SCYL3.				actin filament bundle assembly|axon guidance|cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|membrane to membrane docking|regulation of cell shape	actin filament|apical plasma membrane|basolateral plasma membrane|cortical cytoskeleton|cytosol|extrinsic to membrane|filopodium|microvillus membrane|nucleolus|ruffle membrane	actin filament binding|cell adhesion molecule binding			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-17)|BRCA - Breast invasive adenocarcinoma(81;6.58e-06)		TGGTGGGGGCGGGGGTGCTGT	0.597		NaN											NaN	NaN	NaN	NaN	NaN	56	196	---		---	---
RHBDD2	57414	broad.mit.edu	37	7	75513098	75513100	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr7:75513098_75513100delGAG	uc003udw.1	+	3	753_755	c.669_671delGAG	c.(667-672)ATGAGG>ATG	p.R225del	RHBDD2_uc003udv.1_In_Frame_Del_p.R84del	NM_001040456	NP_001035546	Q6NTF9	RHBD2_HUMAN	rhomboid domain containing 2 isoform a	225						integral to membrane	serine-type endopeptidase activity				0						TCAGCCTGATGAGGAGGATATCC	0.527		NaN											NaN	NaN	NaN	NaN	NaN	68	176	---		---	---
FAM86B1	85002	broad.mit.edu	37	8	12041205	12041205	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr8:12041205delC	uc010lse.2	-	7	846	c.801delG	c.(799-801)GGGfs	p.G267fs	FAM66D_uc011kxp.1_Intron|FAM86B1_uc003wvf.3_RNA|FAM86B1_uc003wvi.3_Frame_Shift_Del_p.D121fs|FAM86B1_uc010lsd.2_RNA|FAM86B1_uc003wvh.3_Frame_Shift_Del_p.G110fs|FAM86B1_uc011kxq.1_Frame_Shift_Del_p.D121fs|FAM86B1_uc010lsf.2_Frame_Shift_Del_p.G110fs|FAM86B1_uc003wvj.3_Frame_Shift_Del_p.G201fs|FAM86B1_uc003wvk.3_Frame_Shift_Del_p.G301fs|FAM86B1_uc010lsg.2_RNA|FAM86B1_uc003wvl.3_RNA	NM_001083537	NP_001077006	Q8N7N1	F86B1_HUMAN	hypothetical protein LOC85002	267											0			STAD - Stomach adenocarcinoma(15;0.033)	COAD - Colon adenocarcinoma(149;0.0965)		CCCATCTGATCCCATCCCGGC	0.552		NaN											NaN	NaN	NaN	NaN	NaN	4	2	---		---	---
SLC46A2	57864	broad.mit.edu	37	9	115652137	115652137	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:115652137delT	uc004bgk.2	-	1	1057	c.825delA	c.(823-825)AAAfs	p.K275fs		NM_033051	NP_149040	Q9BY10	TSCOT_HUMAN	solute carrier family 46, member 2	275	Cytoplasmic (Potential).					integral to membrane|plasma membrane	symporter activity			central_nervous_system(1)	1						GGGGTTTTGCTTTTCCAGGAG	0.537		NaN											NaN	NaN	NaN	NaN	NaN	36	84	---		---	---
NOTCH1	4851	broad.mit.edu	37	9	139390945	139390947	+	In_Frame_Del	DEL	GTG	GTG	-			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chr9:139390945_139390947delGTG	uc004chz.2	-	34	7244_7246	c.7244_7246delCAC	c.(7243-7248)CCACAG>CAG	p.P2415del		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	2415	Cytoplasmic (Potential).|Poly-Pro.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity	p.Q2417*(1)		haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		AGGTGCGGCTGTGGTGGTGGTGG	0.65		NaN	T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			NaN	NaN	NaN	NaN	NaN	8	157	---		---	---
TAF9B	51616	broad.mit.edu	37	X	77387128	77387139	+	In_Frame_Del	DEL	ATCATCTTCATG	ATCATCTTCATG	-			TCGA-FD-A3N5-01A-11D-A21A-08	TCGA-FD-A3N5-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	418a3dec-96ff-4719-becb-e1a8260cce2f	8aee029e-9da1-4714-933a-7613313dd998	g.chrX:77387128_77387139delATCATCTTCATG	uc004eda.2	-	7	795_806	c.724_735delCATGAAGATGAT	c.(724-735)CATGAAGATGATdel	p.HEDD242del		NM_015975	NP_057059	Q9HBM6	TAF9B_HUMAN	transcription associated factor 9B	242_245	Poly-Asp.				negative regulation of apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cell growth|transcription initiation, DNA-dependent	transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding				0						CATTGTCATCATCATCTTCATGTTTTCTCTTC	0.354		NaN											NaN	NaN	NaN	NaN	NaN	19	11	---		---	---
