Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_by_all_platform	validation_method	validation_tumor_sample
PANK4	55229	broad.mit.edu	37	1	2453183	2453183	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:2453183C>G	uc001ajm.1	-	2	190	c.181G>C	c.(181-183)GTG>CTG	p.V61L	PANK4_uc010nza.1_Missense_Mutation_p.V61L	NM_018216	NP_060686	Q9NVE7	PANK4_HUMAN	pantothenate kinase 4	61					coenzyme A biosynthetic process	cytoplasm	ATP binding|pantothenate kinase activity			upper_aerodigestive_tract(1)|large_intestine(1)|ovary(1)	3	all_cancers(77;0.000158)|all_epithelial(69;8.01e-05)|all_lung(157;0.0212)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;3.18e-20)|all_lung(118;1.67e-08)|Lung NSC(185;2.69e-06)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;1.54e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.95e-23)|GBM - Glioblastoma multiforme(42;2.81e-08)|Colorectal(212;4.25e-05)|COAD - Colon adenocarcinoma(227;0.000196)|Kidney(185;0.000342)|BRCA - Breast invasive adenocarcinoma(365;0.00445)|KIRC - Kidney renal clear cell carcinoma(229;0.00549)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.201)		AAAGACCGCACCTTGGCGACT	0.607		NaN											0	0	0	0.010771	0	44	138				
ENO1	2023	broad.mit.edu	37	1	8927305	8927305	+	Silent	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:8927305C>T	uc001apj.1	-	6	466	c.315G>A	c.(313-315)AAG>AAA	p.K105K	ENO1_uc001api.1_Silent_p.K9K|ENO1_uc001apk.1_Silent_p.K50K|ENO1_uc001apl.1_Silent_p.K105K|ENO1_uc009vmi.1_Silent_p.K62K|ENO1_uc009vmj.1_Silent_p.K105K|ENO1_uc009vmk.1_Intron|ENO1_uc009vml.1_Silent_p.K105K	NM_001428	NP_001419	P06733	ENOA_HUMAN	enolase 1	105	Required for repression of c-myc promoter activity.				gluconeogenesis|glycolysis|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|response to virus	phosphopyruvate hydratase complex|plasma membrane|sarcomere	DNA binding|magnesium ion binding|phosphopyruvate hydratase activity|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(2)|kidney(1)|central_nervous_system(1)	4	Ovarian(185;0.0661)|all_lung(157;0.127)	all_epithelial(116;2.54e-20)|all_lung(118;2.99e-06)|Lung NSC(185;6.25e-06)|Renal(390;0.000147)|Breast(348;0.00086)|Colorectal(325;0.00205)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;2.42e-07)|COAD - Colon adenocarcinoma(227;2.78e-05)|Kidney(185;0.000249)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|STAD - Stomach adenocarcinoma(132;0.00177)|BRCA - Breast invasive adenocarcinoma(304;0.00185)|READ - Rectum adenocarcinoma(331;0.0642)		TCGCACCAAACTTAGCTAGAA	0.542		NaN											0	0	0	0.003755	0	35	82				
LOC440563	440563	broad.mit.edu	37	1	13183780	13183780	+	Silent	SNP	A	A	C	rs116484938	by1000genomes	TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:13183780A>C	uc010obg.1	-	1	188	c.93T>G	c.(91-93)TCT>TCG	p.S31S		NM_001136561	NP_001130033	B2RXH8	B2RXH8_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	31						ribonucleoprotein complex	nucleic acid binding|nucleotide binding				0						CCTCCACATCAGATTTCTTGA	0.468		NaN											0	0	0	0.006214	0	6	111				
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:16918653C>T	uc009vos.1	-	6	853	c.-35_splice	c.e6+1		NBPF1_uc010oce.1_Intron	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672							cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418		NaN											0	0	0	0.006214	0	8	110				
ARID1A	8289	broad.mit.edu	37	1	27094374	27094374	+	Silent	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:27094374C>T	uc001bmv.1	+	11	3455	c.3082C>T	c.(3082-3084)CTG>TTG	p.L1028L	ARID1A_uc001bmt.1_Silent_p.L1028L|ARID1A_uc001bmu.1_Silent_p.L1028L|ARID1A_uc001bmw.1_Silent_p.L645L	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1028	ARID.				androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		GGACCGTTATCTGGCCTTCAC	0.502		NaN	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.01441	0	51	100				
CDCA8	55143	broad.mit.edu	37	1	38161616	38161616	+	Silent	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:38161616G>A	uc001cbr.2	+	4	365	c.258G>A	c.(256-258)GCG>GCA	p.A86A	CDCA8_uc001cbs.2_Silent_p.A86A|CDCA8_uc010oih.1_Silent_p.A19A	NM_018101	NP_060571	Q53HL2	BOREA_HUMAN	cell division cycle associated 8	86	Required for centromere localization.|Required for interaction with SENP3.|Required to form a minimal CPC core complex that localizes to the central spindle and midbody and properly executes the role of the CPC during cytokinesis.				cell division|chromosome organization|mitotic metaphase|mitotic prometaphase	chromosome passenger complex|chromosome, centromeric region|cytosol|nucleolus|spindle	protein binding			central_nervous_system(1)	1		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				TGGAAGAGGCGGCAACAGTAA	0.408		NaN											0	0	0	0.004482	0	9	42				
IPO13	9670	broad.mit.edu	37	1	44423127	44423127	+	Silent	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:44423127C>T	uc001ckx.2	+	7	2241	c.1446C>T	c.(1444-1446)GTC>GTT	p.V482V		NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	482	HEAT 8.				protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				CCATTGACGTCAACTATTCTG	0.562		NaN											0	0	0	0.012319	0	11	105				
IPO13	9670	broad.mit.edu	37	1	44423149	44423150	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:44423149_44423150GG>TT	uc001ckx.2	+	7	2263_2264	c.1468_1469GG>TT	c.(1468-1470)GGG>TTG	p.G490L		NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	490	HEAT 8.				protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				TGTGGTGCCTGGGCTCATTGGC	0.559		NaN											0	0	0	0.004672	0	12	116				
ATG4C	84938	broad.mit.edu	37	1	63284996	63284996	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:63284996C>G	uc001dat.2	+	5	877	c.715C>G	c.(715-717)CAC>GAC	p.H239D	ATG4C_uc001dau.2_Missense_Mutation_p.H239D	NM_178221	NP_835739	Q96DT6	ATG4C_HUMAN	APG4 autophagy 4 homolog C isoform 8	239					autophagic vacuole assembly|protein targeting to membrane|proteolysis	cytosol|extracellular region	cysteine-type endopeptidase activity			ovary(1)	1						TGTGGTTGCTCACATTTTAAG	0.363		NaN											0	0	0	0.00632	0	27	63				
LEPR	3953	broad.mit.edu	37	1	66074462	66074462	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:66074462A>G	uc001dci.2	+	12	1832	c.1630A>G	c.(1630-1632)AAA>GAA	p.K544E	LEPR_uc001dcg.2_Missense_Mutation_p.K544E|LEPR_uc001dch.2_Missense_Mutation_p.K544E|LEPR_uc009waq.2_Intron|LEPR_uc001dcj.2_Missense_Mutation_p.K544E|LEPR_uc001dck.2_Missense_Mutation_p.K544E	NM_002303	NP_002294	P48357	LEPR_HUMAN	leptin receptor isoform 1	544	Extracellular (Potential).|Fibronectin type-III 2.				energy reserve metabolic process|multicellular organismal development	extracellular region|integral to membrane|plasma membrane	cytokine receptor activity			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(397;0.00722)|KIRC - Kidney renal clear cell carcinoma(1967;0.094)		ATCCAGTGTGAAAGCAGAAAT	0.313		NaN											0	0	0	0.00308	0	8	50				
DDAH1	23576	broad.mit.edu	37	1	85824470	85824470	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:85824470C>G	uc001dlb.2	-	2	525	c.364G>C	c.(364-366)GAA>CAA	p.E122Q	DDAH1_uc001dlc.2_Missense_Mutation_p.E19Q|uc001dla.1_Intron|DDAH1_uc010osb.1_Missense_Mutation_p.E22Q|DDAH1_uc009wco.2_Missense_Mutation_p.E19Q	NM_012137	NP_036269	O94760	DDAH1_HUMAN	dimethylarginine dimethylaminohydrolase 1	122					arginine catabolic process|citrulline metabolic process|nitric oxide mediated signal transduction		dimethylargininase activity|metal ion binding				0				all cancers(265;0.0318)|Epithelial(280;0.0657)	L-Citrulline(DB00155)	GTTGCATTTTCATCTTTCATC	0.284		NaN											0	0	0	0.00632	0	24	74				
HS2ST1	9653	broad.mit.edu	37	1	87563566	87563566	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:87563566G>C	uc010osk.1	+	5	1019	c.634G>C	c.(634-636)GAG>CAG	p.E212Q	HS2ST1_uc001dmc.3_Missense_Mutation_p.E212Q|LOC339524_uc001dme.1_Missense_Mutation_p.E173Q	NM_012262	NP_036394	Q7LGA3	HS2ST_HUMAN	heparan sulfate 2-O-sulfotransferase 1 isoform	212	Lumenal (Potential).					Golgi membrane|integral to membrane				central_nervous_system(1)	1		Lung NSC(277;0.153)		all cancers(265;0.00699)|Epithelial(280;0.0261)		CTGTGCTCCAGAGAAGCTCTG	0.458		NaN											0	0	0	0.010818	0	30	64				
TGFBR3	7049	broad.mit.edu	37	1	92181853	92181853	+	Silent	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:92181853G>A	uc001doh.2	-	12	2272	c.1806C>T	c.(1804-1806)CTC>CTT	p.L602L	TGFBR3_uc009wde.2_Silent_p.L379L|TGFBR3_uc010osy.1_Silent_p.L560L|TGFBR3_uc001doi.2_Silent_p.L601L|TGFBR3_uc001doj.2_Silent_p.L601L	NM_003243	NP_003234	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	602	ZP.|Extracellular (Potential).				BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			ovary(3)	3		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		GCACCAAAAAGAGGTCAGTGT	0.502		NaN											0	0	0	0.003163	0	15	40				
C1orf146	388649	broad.mit.edu	37	1	92710355	92710355	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:92710355C>G	uc001doq.2	+	5	421	c.349C>G	c.(349-351)CGA>GGA	p.R117G	C1orf146_uc010ote.1_Missense_Mutation_p.R58G	NM_001012425	NP_001012425	Q5VVC0	CA146_HUMAN	hypothetical protein LOC388649	117										ovary(1)	1		all_lung(203;0.00528)|Lung NSC(277;0.0193)		all cancers(265;0.00846)|Epithelial(280;0.0952)		TTGTAACTTACGAATACTTCC	0.353		NaN											0	0	0	0.004878	0	33	52				
PTBP2	58155	broad.mit.edu	37	1	97236333	97236333	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:97236333C>G	uc001drq.2	+	5	604	c.358C>G	c.(358-360)CAT>GAT	p.H120D	PTBP2_uc001drn.2_Missense_Mutation_p.H120D|PTBP2_uc001dro.2_Missense_Mutation_p.H120D|PTBP2_uc010otz.1_Missense_Mutation_p.H131D|PTBP2_uc001drp.2_RNA|PTBP2_uc009wdw.2_Missense_Mutation_p.H68D|PTBP2_uc001drr.2_Missense_Mutation_p.H120D|PTBP2_uc010oua.1_Missense_Mutation_p.H128D|PTBP2_uc001dru.2_RNA|PTBP2_uc001drm.2_Missense_Mutation_p.H120D	NM_021190	NP_067013	Q9UKA9	PTBP2_HUMAN	polypyrimidine tract binding protein 2	120	RRM 1.						nucleotide binding				0		all_epithelial(167;2.95e-05)|all_lung(203;0.000396)|Lung NSC(277;0.00171)		all cancers(265;0.0582)|Epithelial(280;0.0716)|Colorectal(170;0.0879)|KIRC - Kidney renal clear cell carcinoma(1967;0.202)		TGTGACACCTCATCTTCGTAA	0.323		NaN											0	0	0	0.013726	0	34	71				
HIPK1	204851	broad.mit.edu	37	1	114483496	114483496	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:114483496C>T	uc001eem.2	+	2	652	c.491C>T	c.(490-492)ACA>ATA	p.T164I	HIPK1_uc001eel.2_Missense_Mutation_p.T164I|HIPK1_uc001een.2_Missense_Mutation_p.T164I	NM_198268	NP_938009	Q86Z02	HIPK1_HUMAN	homeodomain-interacting protein kinase 1 isoform	164					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(4)	4	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.09e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACTGTGACCACAAAGAGTAGC	0.517		NaN											0	0	0	0.007835	0	40	62				
VANGL1	81839	broad.mit.edu	37	1	116206768	116206768	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:116206768C>T	uc001efv.1	+	4	962	c.691C>T	c.(691-693)CTC>TTC	p.L231F	VANGL1_uc009wgy.1_Missense_Mutation_p.L229F|VANGL1_uc001efw.1_Missense_Mutation_p.L231F	NM_138959	NP_620409	Q8TAA9	VANG1_HUMAN	vang-like 1	231	Helical; Name=4; (Potential).				multicellular organismal development	integral to membrane	protein binding			central_nervous_system(1)	1	Lung SC(450;0.211)	all_cancers(81;1.24e-06)|all_epithelial(167;1.02e-06)|all_lung(203;7.95e-06)|Lung NSC(69;4.97e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		GGATGCCCTCCTCTTCATCCA	0.572		NaN											0	0	0	0.014323	0	22	86				
ADAMTSL4	54507	broad.mit.edu	37	1	150526564	150526564	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:150526564G>C	uc001eux.2	+	6	1333	c.1097G>C	c.(1096-1098)GGG>GCG	p.G366A	ADAMTSL4_uc001euw.2_Missense_Mutation_p.G366A|ADAMTSL4_uc009wlw.2_Missense_Mutation_p.G366A|ADAMTSL4_uc010pcg.1_Missense_Mutation_p.G366A	NM_019032	NP_061905	Q6UY14	ATL4_HUMAN	thrombospondin repeat containing 1 isoform 1	366					apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			ovary(1)|skin(1)	2	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			AGATGTTCTGGGGAGAGTGAA	0.652		NaN											0	0	0	0.013537	0	12	46				
MEX3A	92312	broad.mit.edu	37	1	156051352	156051352	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:156051352C>G	uc001fnd.3	-	1	438	c.438G>C	c.(436-438)GAG>GAC	p.E146D	LMNA_uc001fnf.1_5'Flank	NM_001093725	NP_001087194	A1L020	MEX3A_HUMAN	MEX3A protein	146	KH 1.					cytoplasmic mRNA processing body|nucleus	RNA binding|zinc ion binding				0	Hepatocellular(266;0.158)|all_neural(408;0.195)					TGCCCACGATCTCGGCCACGT	0.637		NaN											0	0	0	0.009096	0	4	9				
OR10J3	441911	broad.mit.edu	37	1	159283465	159283465	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:159283465A>G	uc010piu.1	-	1	985	c.985T>C	c.(985-987)TAC>CAC	p.Y329H		NM_001004467	NP_001004467	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J,	329	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_hematologic(112;0.0429)					AAAAATTAGTACATATTTATA	0.393		NaN											0	0	0	0.013726	0	32	66				
POU2F1	5451	broad.mit.edu	37	1	167339439	167339439	+	Silent	SNP	T	T	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:167339439T>G	uc001gec.2	+	5	363	c.201T>G	c.(199-201)TCT>TCG	p.S67S	POU2F1_uc010plg.1_RNA|POU2F1_uc001ged.2_Silent_p.S65S|POU2F1_uc001gee.2_Silent_p.S67S|POU2F1_uc010plh.1_Silent_p.S67S|POU2F1_uc001gef.2_Silent_p.S79S|POU2F1_uc001geg.2_5'Flank	NM_002697	NP_002688	P14859	PO2F1_HUMAN	POU class 2 homeobox 1	67					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase III promoter	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|skin(2)|breast(1)	5						CTGCTCAGTCTTTAAATGTAC	0.358		NaN											0	0	0	0.008361	0	28	134				
DCAF6	55827	broad.mit.edu	37	1	167921068	167921068	+	Missense_Mutation	SNP	T	T	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:167921068T>G	uc001gew.2	+	2	370	c.128T>G	c.(127-129)CTT>CGT	p.L43R	DCAF6_uc001gev.2_Missense_Mutation_p.L43R|DCAF6_uc001gex.2_Missense_Mutation_p.L43R|DCAF6_uc010plk.1_Missense_Mutation_p.L43R	NM_001017977	NP_001017977	Q58WW2	DCAF6_HUMAN	IQ motif and WD repeats 1 isoform b	43					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						AGATTAAAACTTGAAGCAACC	0.279		NaN											0	0	0	0.01441	0	55	32				
SELE	6401	broad.mit.edu	37	1	169696572	169696572	+	Silent	SNP	A	A	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:169696572A>C	uc001ggm.3	-	10	1720	c.1563T>G	c.(1561-1563)CCT>CCG	p.P521P	C1orf112_uc001ggj.2_Intron	NM_000450	NP_000441	P16581	LYAM2_HUMAN	selectin E precursor	521	Extracellular (Potential).|Sushi 6.				actin filament-based process|activation of phospholipase C activity|calcium-mediated signaling|heterophilic cell-cell adhesion|leukocyte migration involved in inflammatory response|leukocyte tethering or rolling|positive regulation of receptor internalization|regulation of inflammatory response|response to interleukin-1|response to lipopolysaccharide|response to tumor necrosis factor	caveola|coated pit|cortical cytoskeleton|extracellular space|integral to membrane|perinuclear region of cytoplasm	oligosaccharide binding|phospholipase binding|sialic acid binding|transmembrane receptor activity			ovary(3)|skin(2)	5	all_hematologic(923;0.208)					TCCATCCTTCAGGACAGGCGA	0.542		NaN											0	0	0	0.01441	0	55	56				
ABL2	27	broad.mit.edu	37	1	179077602	179077602	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:179077602G>A	uc001gmj.3	-	12	3087	c.2800C>T	c.(2800-2802)CTT>TTT	p.L934F	ABL2_uc010pnf.1_Missense_Mutation_p.L831F|ABL2_uc010png.1_Missense_Mutation_p.L810F|ABL2_uc010pnh.1_Missense_Mutation_p.L913F|ABL2_uc001gmg.3_Missense_Mutation_p.L816F|ABL2_uc001gmi.3_Missense_Mutation_p.L919F|ABL2_uc001gmh.3_Missense_Mutation_p.L898F|ABL2_uc010pne.1_Missense_Mutation_p.L795F	NM_007314	NP_009298	P42684	ABL2_HUMAN	arg tyrosine kinase isoform b	934	Pro-rich.				axon guidance|cell adhesion|peptidyl-tyrosine phosphorylation|positive regulation of oxidoreductase activity|signal transduction	cytoskeleton|cytosol	ATP binding|magnesium ion binding|manganese ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(8)|breast(3)|ovary(2)|central_nervous_system(1)	14					Adenosine triphosphate(DB00171)|Dasatinib(DB01254)	GGTGAGATAAGGACTGGCACT	0.557		NaN	T	ETV6	AML								0	0	0	0.01441	0	66	55				
DHX9	1660	broad.mit.edu	37	1	182812436	182812436	+	Missense_Mutation	SNP	T	T	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:182812436T>G	uc001gpr.2	+	3	282	c.119T>G	c.(118-120)GTG>GGG	p.V40G	DHX9_uc001gps.2_5'UTR	NM_001357	NP_001348	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 9	40	DRBM 1.|Interaction with CREBBP.				CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			ovary(2)	2						AAGGTTCAGGTGGAAGGTTAT	0.333		NaN											0	0	0	0.00499	0	9	63				
GLT25D2	23127	broad.mit.edu	37	1	183908076	183908076	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:183908076C>T	uc001gqr.2	-	12	2072	c.1700G>A	c.(1699-1701)GGG>GAG	p.G567E	GLT25D2_uc010poj.1_Intron|GLT25D2_uc001gqp.2_Missense_Mutation_p.G175E|GLT25D2_uc001gqq.2_Missense_Mutation_p.G304E|GLT25D2_uc001gqs.2_Missense_Mutation_p.G447E	NM_015101	NP_055916	Q8IYK4	GT252_HUMAN	glycosyltransferase 25 domain containing 2	567					lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen	procollagen galactosyltransferase activity			ovary(1)|breast(1)	2						ACTCAGGTACCCCGGCTGGCC	0.562		NaN											0	0	0	0.00499	0	18	134				
HMCN1	83872	broad.mit.edu	37	1	186022986	186022986	+	Silent	SNP	C	C	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:186022986C>A	uc001grq.1	+	44	6959	c.6730C>A	c.(6730-6732)CGA>AGA	p.R2244R		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	2244	Ig-like C2-type 20.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TTCCATGGGGCGAGTTAGAAT	0.428		NaN											1	0	1.15088e-07	0.004007	1.21879e-07	16	95				
KIF14	9928	broad.mit.edu	37	1	200569537	200569537	+	Silent	SNP	T	T	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:200569537T>A	uc010ppk.1	-	12	2686	c.2247A>T	c.(2245-2247)ACA>ACT	p.T749T	KIF14_uc010ppj.1_Silent_p.T258T	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14	749	Potential.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7						TTCTTAAGGATGTTATTTCTT	0.413		NaN											0	0	0	0.01441	0	63	293				
HEATR1	55127	broad.mit.edu	37	1	236767261	236767261	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:236767261G>T	uc001hyd.1	-	2	260	c.135C>A	c.(133-135)TTC>TTA	p.F45L	HEATR1_uc001hye.1_Missense_Mutation_p.F45L	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	45					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			CACCAATGGCGAAGGCGGTGT	0.443		NaN											1	0	7.45023e-12	0.010504	8.06516e-12	20	29				
OR2L3	391192	broad.mit.edu	37	1	248224761	248224761	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr1:248224761C>T	uc001idx.1	+	1	778	c.778C>T	c.(778-780)CGT>TGT	p.R260C	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	260	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CACTTATCTACGTCCAAGATC	0.488		NaN											0	0	0	0.01441	0	47	118				
BICC1	80114	broad.mit.edu	37	10	60560788	60560788	+	Missense_Mutation	SNP	C	C	T	rs139193189	byFrequency	TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr10:60560788C>T	uc001jki.1	+	14	1997	c.1997C>T	c.(1996-1998)ACG>ATG	p.T666M	BICC1_uc001jkj.1_Missense_Mutation_p.T307M	NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1	666					multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4						TTGCAAGGCACGAAAAACTCA	0.383		NaN											0	0	0	0.013537	0	13	54				
MAT1A	4143	broad.mit.edu	37	10	82036336	82036336	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr10:82036336G>T	uc001kbw.2	-	6	819	c.564C>A	c.(562-564)TAC>TAA	p.Y188*		NM_000429	NP_000420	Q00266	METK1_HUMAN	methionine adenosyltransferase I, alpha	188					methylation|S-adenosylmethionine biosynthetic process|xenobiotic metabolic process	cytosol	ATP binding|metal ion binding|methionine adenosyltransferase activity				0			Colorectal(32;0.229)		L-Methionine(DB00134)|S-Adenosylmethionine(DB00118)	TGTCCTGCATGTACTGAACTG	0.592		NaN											1	0	7.05121e-23	0.010771	7.98825e-23	45	105				
TNKS2	80351	broad.mit.edu	37	10	93582057	93582057	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr10:93582057C>G	uc001khp.2	+	7	1030	c.733C>G	c.(733-735)CTG>GTG	p.L245V		NM_025235	NP_079511	Q9H2K2	TNKS2_HUMAN	tankyrase, TRF1-interacting ankyrin-related	245	ANK 5.				positive regulation of canonical Wnt receptor signaling pathway|protein auto-ADP-ribosylation|protein localization to chromosome, telomeric region|protein polyubiquitination|Wnt receptor signaling pathway	Golgi membrane|microsome|nuclear envelope|pericentriolar material|perinuclear region of cytoplasm	NAD+ ADP-ribosyltransferase activity|protein binding			kidney(3)|skin(3)|ovary(1)|lung(1)	8		Colorectal(252;0.162)				TTGTAGTGATCTGGTACCATT	0.328		NaN											0	0	0	0.006999	0	38	116				
SFRP5	6425	broad.mit.edu	37	10	99529459	99529459	+	Silent	SNP	G	G	A	rs144832598	byFrequency	TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr10:99529459G>A	uc001kor.3	-	2	739	c.573C>T	c.(571-573)GAC>GAT	p.D191D		NM_003015	NP_003006	Q5T4F7	SFRP5_HUMAN	secreted frizzled-related protein 5 precursor	191	NTR.				apoptosis|brain development|cell differentiation|embryo development|establishment or maintenance of cell polarity|gonad development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of cell proliferation|negative regulation of protein kinase B signaling cascade|negative regulation of sequence-specific DNA binding transcription factor activity|vasculature development|visual perception	cytoplasm|extracellular space|plasma membrane	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1		Colorectal(252;0.234)		Epithelial(162;4.98e-10)|all cancers(201;3.58e-08)		CCATGAGGCCGTCAGCACTGT	0.602		NaN											0	0	0	0.009096	0	3	21				
SEC31B	25956	broad.mit.edu	37	10	102262099	102262099	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr10:102262099A>G	uc001krc.1	-	11	1424	c.1322T>C	c.(1321-1323)TTG>TCG	p.L441S	SEC31B_uc010qpo.1_Missense_Mutation_p.L440S|SEC31B_uc001krd.1_5'UTR|SEC31B_uc001krf.1_5'UTR|SEC31B_uc001kre.1_5'UTR|SEC31B_uc001krg.1_Missense_Mutation_p.L10S	NM_015490	NP_056305	Q9NQW1	SC31B_HUMAN	SEC31 homolog B	441					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane				ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.36e-10)|all cancers(201;2.09e-08)		TCCTGATCCCAAGGCCTCCTG	0.517		NaN											0	0	0	0.008361	0	32	72				
FAM178A	55719	broad.mit.edu	37	10	102676648	102676648	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr10:102676648G>C	uc001krt.3	+	3	1048	c.506G>C	c.(505-507)CGA>CCA	p.R169P	FAM178A_uc001krr.1_Missense_Mutation_p.R169P|FAM178A_uc001krs.2_Missense_Mutation_p.R169P|FAM178A_uc001kru.1_Missense_Mutation_p.R105P	NM_018121	NP_060591	Q8IX21	F178A_HUMAN	hypothetical protein LOC55719 isoform 1	169											0						AAAAAACATCGATCCCCAGAG	0.383		NaN											0	0	0	0.005443	0	29	59				
SLK	9748	broad.mit.edu	37	10	105779625	105779625	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr10:105779625G>T	uc001kxo.1	+	16	3300	c.3266G>T	c.(3265-3267)AGT>ATT	p.S1089I	SLK_uc001kxp.1_Missense_Mutation_p.S1058I	NM_014720	NP_055535	Q9H2G2	SLK_HUMAN	serine/threonine kinase 2	1089					apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			ovary(2)|stomach(2)|skin(2)|lung(1)|kidney(1)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		TTTAAGAAGAGTTTGAGAATT	0.378		NaN											1	0	8.72198e-27	0.01441	1.00141e-26	43	95				
PDZD8	118987	broad.mit.edu	37	10	119043391	119043391	+	Silent	SNP	G	G	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr10:119043391G>C	uc001lde.1	-	5	3052	c.2853C>G	c.(2851-2853)GTC>GTG	p.V951V		NM_173791	NP_776152	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	951					intracellular signal transduction		metal ion binding				0		Colorectal(252;0.19)		all cancers(201;0.0121)		GAGTTTTAGAGACTTGACGCA	0.433		NaN											0	0	0	0.01441	0	81	218				
EBF3	253738	broad.mit.edu	37	10	131761227	131761227	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr10:131761227G>C	uc001lki.1	-	3	393	c.334C>G	c.(334-336)CTC>GTC	p.L112V	EBF3_uc010qur.1_3'UTR	NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3	112					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		AATAACTGGAGTTTATAGTGG	0.507		NaN											0	0	0	0.014323	0	21	67				
CTSD	1509	broad.mit.edu	37	11	1782613	1782613	+	Missense_Mutation	SNP	C	C	T	rs143517230	byFrequency	TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr11:1782613C>T	uc001luc.1	-	2	287	c.154G>A	c.(154-156)GTC>ATC	p.V52I	CTSD_uc009yda.1_RNA	NM_001909	NP_001900	P07339	CATD_HUMAN	cathepsin D preproprotein	52					cell death|proteolysis	extracellular space|lysosome|melanosome	aspartic-type endopeptidase activity				0		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TACTTTGAGACGGGGCCTTTG	0.612		NaN											0	0	0	0.007413	0	19	23				
NUP98	4928	broad.mit.edu	37	11	3794940	3794940	+	Missense_Mutation	SNP	T	T	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr11:3794940T>G	uc001lyh.2	-	6	816	c.525A>C	c.(523-525)AAA>AAC	p.K175N	NUP98_uc001lyi.2_Missense_Mutation_p.K175N|NUP98_uc001lyj.1_Missense_Mutation_p.K175N|NUP98_uc001lyk.1_Missense_Mutation_p.K175N|NUP98_uc010qxv.1_Missense_Mutation_p.K138N	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	175	Gly/Thr-rich.				carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		TAACTCCAGCTTTGACCATAG	0.368		NaN	T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								0	0	0	0.00245	0	11	23				
OR10A5	144124	broad.mit.edu	37	11	6866955	6866955	+	Silent	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr11:6866955C>T	uc001met.1	+	1	42	c.42C>T	c.(40-42)CTC>CTT	p.L14L		NM_178168	NP_835462	Q9H207	O10A5_HUMAN	olfactory receptor, family 10, subfamily A,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		AATTTATCCTCATGAGCTTCT	0.413		NaN											0	0	0	0.01441	0	95	125				
OR10V1	390201	broad.mit.edu	37	11	59480630	59480630	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr11:59480630C>T	uc001nof.1	-	1	689	c.689G>A	c.(688-690)CGG>CAG	p.R230Q		NM_001005324	NP_001005324	Q8NGI7	O10V1_HUMAN	olfactory receptor, family 10, subfamily V,	230	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TTCTGCTGACCGGATCCGTAA	0.502		NaN											0	0	0	0.004289	0	36	66				
GAB2	9846	broad.mit.edu	37	11	77991880	77991880	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr11:77991880T>C	uc001ozh.2	-	2	143	c.143A>G	c.(142-144)TAC>TGC	p.Y48C	GAB2_uc001ozg.2_Missense_Mutation_p.Y10C	NM_080491	NP_536739	Q9UQC2	GAB2_HUMAN	GRB2-associated binding protein 2 isoform a	48	PH.				osteoclast differentiation|phosphatidylinositol-mediated signaling|positive regulation of cell proliferation|positive regulation of mast cell degranulation	cytosol|plasma membrane	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|transmembrane receptor protein tyrosine kinase adaptor activity			ovary(5)|lung(1)	6	all_cancers(14;3.31e-18)|all_epithelial(13;5.3e-21)|Breast(9;5.6e-16)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;1.58e-23)			GTTCTTGTAGTATTCCAGAAC	0.507		NaN											0	0	0	0.004878	0	38	71				
GRM5	2915	broad.mit.edu	37	11	88301116	88301116	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr11:88301116C>T	uc001pcq.2	-	7	1935	c.1735G>A	c.(1735-1737)GAA>AAA	p.E579K	GRM5_uc009yvm.2_Missense_Mutation_p.E579K	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	579	Extracellular (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	GCAATGGGTTCAGGGTCACCC	0.488		NaN											0	0	0	0.004007	0	16	25				
ATM	472	broad.mit.edu	37	11	108122624	108122624	+	Silent	SNP	A	A	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr11:108122624A>G	uc001pkb.1	+	11	2053	c.1668A>G	c.(1666-1668)AAA>AAG	p.K556K	ATM_uc009yxr.1_Silent_p.K556K	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	556					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		GAACGGTAAAAATGGGAATAG	0.358		NaN	D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			0	0	0	0.01441	0	49	65				
GRIK4	2900	broad.mit.edu	37	11	120531041	120531041	+	Missense_Mutation	SNP	C	C	T	rs138617238		TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr11:120531041C>T	uc001pxn.2	+	3	301	c.14C>T	c.(13-15)TCG>TTG	p.S5L	GRIK4_uc009zav.1_Missense_Mutation_p.S5L|GRIK4_uc009zaw.1_Missense_Mutation_p.S5L|GRIK4_uc009zax.1_Missense_Mutation_p.S5L	NM_014619	NP_055434	Q16099	GRIK4_HUMAN	glutamate receptor KA1 precursor	5					glutamate signaling pathway|synaptic transmission	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|central_nervous_system(1)	3		Breast(109;0.000868)|Medulloblastoma(222;0.0453)|all_neural(223;0.116)|all_hematologic(192;0.21)		BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.116)	L-Glutamic Acid(DB00142)	CCCCGCGTCTCGGCGCCTTTG	0.647		NaN									OREG0021424	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008291	0	10	60				
HSPA8	3312	broad.mit.edu	37	11	122928487	122928487	+	Silent	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr11:122928487G>A	uc001pyo.2	-	9	1974	c.1896C>T	c.(1894-1896)CCC>CCT	p.P632P	HSPA8_uc009zbc.2_Silent_p.P396P|HSPA8_uc001pyp.2_Silent_p.P479P|HSPA8_uc010rzu.1_Silent_p.P555P	NM_006597	NP_006588	P11142	HSP7C_HUMAN	heat shock 70kDa protein 8 isoform 1	632					cellular membrane organization|interspecies interaction between organisms|mRNA metabolic process|negative regulation of transcription, DNA-dependent|neurotransmitter secretion|post-Golgi vesicle-mediated transport|protein folding|response to unfolded protein|transcription, DNA-dependent	cell surface|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|melanosome|plasma membrane|ribonucleoprotein complex	ATP binding|ATPase activity, coupled|protein binding			central_nervous_system(7)|lung(1)	8		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		CACCACCAGAGGGAGGAGCTC	0.512		NaN											0	0	0	0.00245	0	14	78				
C11orf45	219833	broad.mit.edu	37	11	128773387	128773387	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr11:128773387C>A	uc001qeu.2	-	3	350	c.156G>T	c.(154-156)AGG>AGT	p.R52S	KCNJ5_uc001qet.2_Intron|KCNJ5_uc009zck.2_Intron|C11orf45_uc009zcl.2_Missense_Mutation_p.R52S|C11orf45_uc001qev.2_Missense_Mutation_p.R52S	NM_145013	NP_659450	Q8TAV5	CK045_HUMAN	hypothetical protein LOC219833 precursor	52						extracellular region					0	all_hematologic(175;0.0641)	Lung NSC(97;0.00521)|Breast(109;0.00715)|all_lung(97;0.0111)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.00531)|LUSC - Lung squamous cell carcinoma(976;0.0193)|Lung(977;0.0195)		TACCCTCACTCCTGACAGAGG	0.507		NaN											1	0	0.00198382	0.001984	0.00201935	6	42				
DPPA3	359787	broad.mit.edu	37	12	7868804	7868804	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:7868804G>A	uc001qtf.2	+	3	416	c.338G>A	c.(337-339)AGA>AAA	p.R113K		NM_199286	NP_954980	Q6W0C5	DPPA3_HUMAN	stella	113						cytoplasm|nucleus					0				Kidney(36;0.0887)		CATGAAAGAAGACCAACAAAC	0.284		NaN											0	0	0	0.001984	0	6	20				
CREBL2	1389	broad.mit.edu	37	12	12788795	12788795	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:12788795C>T	uc001rap.1	+	2	376	c.100C>T	c.(100-102)CGG>TGG	p.R34W	CREBL2_uc009zhv.1_5'Flank	NM_001310	NP_001301	O60519	CRBL2_HUMAN	cAMP responsive element binding protein-like 2	34	Basic motif.				cell cycle|signal transduction	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		Prostate(47;0.0684)		BRCA - Breast invasive adenocarcinoma(232;0.0503)		TGAGAGGAGCCGGCAGAGTGC	0.488		NaN											0	0	0	0.010729	0	11	14				
ARF3	377	broad.mit.edu	37	12	49334730	49334730	+	Splice_Site	SNP	C	C	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:49334730C>G	uc001rsr.2	-	2	401	c.148_splice	c.e2+1	p.G50_splice	ARF3_uc010smc.1_Splice_Site_p.G50_splice	NM_001659	NP_001650	P61204	ARF3_HUMAN	ADP-ribosylation factor 3						protein transport|small GTPase mediated signal transduction|vesicle-mediated transport	Golgi apparatus|perinuclear region of cytoplasm	GTP binding|GTPase activity				0						TGTGCTCTTACCAATGGTAGG	0.587		NaN											0	0	0	0.01441	0	56	66				
LETMD1	25875	broad.mit.edu	37	12	51442969	51442969	+	Splice_Site	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:51442969G>A	uc001rxm.2	+	2	330	c.274_splice	c.e2+1	p.G92_splice	LETMD1_uc010smz.1_Splice_Site_p.G92_splice|LETMD1_uc010sna.1_Splice_Site_p.E92_splice|LETMD1_uc001rxl.2_Splice_Site_p.G36_splice|LETMD1_uc009zlv.2_Splice_Site|LETMD1_uc001rxs.2_Splice_Site_p.E92_splice|LETMD1_uc009zlw.2_Splice_Site_p.G92_splice|LETMD1_uc001rxn.2_Splice_Site|LETMD1_uc001rxo.2_Splice_Site|LETMD1_uc001rxp.2_Intron|LETMD1_uc001rxq.2_Splice_Site_p.G92_splice|LETMD1_uc001rxr.2_Splice_Site|LETMD1_uc001rxt.2_Splice_Site	NM_015416	NP_056231	Q6P1Q0	LTMD1_HUMAN	LETM1 domain containing 1 isoform 1							integral to membrane|mitochondrial outer membrane	protein binding			central_nervous_system(2)	2						TTCATGAAAGGTAAAAACGAA	0.413		NaN											0	0	0	0.001168	0	5	34				
KRT7	3855	broad.mit.edu	37	12	52642496	52642496	+	Silent	SNP	T	T	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:52642496T>G	uc001saa.1	+	9	1489	c.1362T>G	c.(1360-1362)GCT>GCG	p.A454A	KRT86_uc010snq.1_5'Flank	NM_005556	NP_005547	P08729	K2C7_HUMAN	keratin 7	454	Tail.				cytoskeleton organization|DNA replication|interphase|interspecies interaction between organisms|regulation of translation	Golgi apparatus|keratin filament|nucleus	protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.105)		TCCTGAAGGCTTATTCCATCC	0.642		NaN											0	0	0	0.006122	0	17	31				
STAT6	6778	broad.mit.edu	37	12	57501482	57501482	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:57501482C>T	uc009zpe.2	-	3	412	c.161G>A	c.(160-162)AGT>AAT	p.S54N	STAT6_uc009zpf.2_Missense_Mutation_p.S54N|STAT6_uc001sna.2_Missense_Mutation_p.S54N|STAT6_uc010srb.1_Translation_Start_Site|STAT6_uc010src.1_Intron|STAT6_uc010srd.1_Intron|STAT6_uc009zpg.2_Missense_Mutation_p.S103N	NM_003153	NP_003144	P42226	STAT6_HUMAN	signal transducer and activator of transcription	54					regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	calcium ion binding|DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(2)|lung(1)|skin(1)	4						AAGTAGGGCACTAGCCAAGTT	0.607		NaN											0	0	0	0.001984	0	5	44				
LRP1	4035	broad.mit.edu	37	12	57556105	57556105	+	Silent	SNP	G	G	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:57556105G>T	uc001snd.2	+	14	2674	c.2208G>T	c.(2206-2208)GTG>GTT	p.V736V		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	736	LDL-receptor class B 7.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CCTAGATTGTGTATGAAGGTC	0.488		NaN											1	0	1.45844e-13	0.013726	1.60428e-13	33	85				
NUP107	57122	broad.mit.edu	37	12	69113358	69113358	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:69113358G>C	uc001suf.2	+	14	1290	c.1175G>C	c.(1174-1176)GGA>GCA	p.G392A	NUP107_uc001sug.2_Missense_Mutation_p.G239A|NUP107_uc010stj.1_Missense_Mutation_p.G363A	NM_020401	NP_065134	P57740	NU107_HUMAN	nucleoporin 107kDa	392					carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA export from nucleus|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	nucleocytoplasmic transporter activity|protein binding			skin(1)	1	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			TATTTTATAGGAACAGAATTA	0.308		NaN											0	0	0	0.013537	0	12	34				
TMTC2	160335	broad.mit.edu	37	12	83324287	83324287	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:83324287T>C	uc001szt.2	+	4	1993	c.1561T>C	c.(1561-1563)TAC>CAC	p.Y521H	TMTC2_uc001szr.1_Missense_Mutation_p.Y521H|TMTC2_uc001szs.1_Missense_Mutation_p.Y521H|TMTC2_uc010suk.1_Missense_Mutation_p.Y276H	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat	521	TPR 2.					endoplasmic reticulum|integral to membrane	binding			ovary(2)	2						AAATGCTTTGTACTACCGCAG	0.418		NaN											0	0	0	0.007413	0	17	28				
LRRIQ1	84125	broad.mit.edu	37	12	85450778	85450778	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:85450778A>T	uc001tac.2	+	8	2318	c.2207A>T	c.(2206-2208)TAT>TTT	p.Y736F	LRRIQ1_uc001tab.1_Missense_Mutation_p.Y736F|LRRIQ1_uc001taa.1_Missense_Mutation_p.Y711F	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	736										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		ACCCTTCTATATTCTATTGAA	0.333		NaN											0	0	0	0.01441	0	72	263				
GALNT4	8693	broad.mit.edu	37	12	89917268	89917268	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:89917268C>A	uc001tbd.2	-	1	1268	c.1059G>T	c.(1057-1059)GAG>GAT	p.E353D	POC1B_uc001tba.2_Intron|POC1B_uc001tbb.2_Intron|POC1B_uc001tbc.2_Intron|POC1B_uc010sun.1_Intron|GALNT4_uc001tbe.2_Missense_Mutation_p.E350D|GALNT4_uc010suo.1_Missense_Mutation_p.E45D	NM_003774	NP_003765	Q8N4A0	GALT4_HUMAN	polypeptide N-acetylgalactosaminyltransferase 4	353	Catalytic subdomain B.|Lumenal (Potential).				carbohydrate metabolic process	Golgi membrane|integral to membrane|perinuclear region of cytoplasm	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0						ACGGGTGGATCTCCAATTTGC	0.522		NaN											1	0	1.73308e-25	0.012319	1.97653e-25	23	125				
ATP2B1	490	broad.mit.edu	37	12	90013790	90013790	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:90013790C>G	uc001tbh.2	-	10	1996	c.1815G>C	c.(1813-1815)GAG>GAC	p.E605D	ATP2B1_uc001tbg.2_Missense_Mutation_p.E605D|ATP2B1_uc001tbf.2_Missense_Mutation_p.E275D	NM_001682	NP_001673	P20020	AT2B1_HUMAN	plasma membrane calcium ATPase 1 isoform 1b	605	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3						TCAGAATTATCTCAGATGCAC	0.343		NaN											0	0	0	0.012213	0	32	57				
BTBD11	121551	broad.mit.edu	37	12	107713306	107713306	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:107713306G>T	uc001tmk.1	+	1	1110	c.589G>T	c.(589-591)GAC>TAC	p.D197Y	BTBD11_uc009zut.1_Missense_Mutation_p.D197Y|BTBD11_uc001tmj.2_Missense_Mutation_p.D197Y	NM_001018072	NP_001018082	A6QL63	BTBDB_HUMAN	BTB (POZ) domain containing 11 isoform a	197						integral to membrane	DNA binding			skin(2)|ovary(1)	3						CGCCGGCGGCGACCGCCTGGG	0.721		NaN											1	0	0.004672	0.004672	0.00472745	3	4				
ATP2A2	488	broad.mit.edu	37	12	110783086	110783086	+	Silent	SNP	G	G	C	rs147309970		TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:110783086G>C	uc001tqk.3	+	18	3203	c.2640G>C	c.(2638-2640)CCG>CCC	p.P880P	ATP2A2_uc001tql.3_Silent_p.P880P|ATP2A2_uc010sxy.1_Silent_p.P853P|ATP2A2_uc001tqn.3_5'Flank|ATP2A2_uc009zvn.2_5'Flank	NM_170665	NP_733765	P16615	AT2A2_HUMAN	ATPase, Ca++ transporting, slow twitch 2 isoform	880	Lumenal (By similarity).				ATP biosynthetic process|cell adhesion|epidermis development|platelet activation|sarcoplasmic reticulum calcium ion transport	integral to plasma membrane|microsome|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|protein C-terminus binding|S100 alpha binding			ovary(3)|skin(1)	4						AGGACAACCCGGACTTTGAAG	0.448		NaN											0	0	0	0.01441	0	62	158				
ATXN2	6311	broad.mit.edu	37	12	111953957	111953957	+	Splice_Site	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:111953957C>T	uc001tsj.2	-	10	2017	c.1855_splice	c.e10+1	p.G619_splice	ATXN2_uc001tsh.2_Splice_Site_p.G354_splice|ATXN2_uc001tsi.2_Splice_Site_p.G330_splice|ATXN2_uc001tsk.2_Splice_Site|ATXN2_uc001tsm.1_Splice_Site_p.G354_splice	NM_002973	NP_002964	Q99700	ATX2_HUMAN	ataxin 2						cell death|cytoplasmic mRNA processing body assembly|regulation of translation|RNA metabolic process|RNA transport|stress granule assembly	nucleus|perinuclear region of cytoplasm|polysome|stress granule|trans-Golgi network	protein C-terminus binding|RNA binding			ovary(1)|breast(1)	2						TGGTATTGTACCTTCTGAAGA	0.428		NaN											0	0	0	0.001984	0	6	26				
HSPB8	26353	broad.mit.edu	37	12	119617346	119617346	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:119617346G>T	uc001txb.2	+	1	752	c.229G>T	c.(229-231)GCC>TCC	p.A77S	HSPB8_uc001txc.2_Missense_Mutation_p.A77S	NM_014365	NP_055180	Q9UJY1	HSPB8_HUMAN	heat shock 22kDa protein 8	77					cell death|response to heat	cytoplasm|nucleus	identical protein binding|protein serine/threonine kinase activity			central_nervous_system(1)|skin(1)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CACTGCCACCGCCAGGTTTGG	0.672		NaN											1	0	0.00010058	0.013537	0.000104886	13	40				
VPS37B	79720	broad.mit.edu	37	12	123355588	123355588	+	Silent	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:123355588G>A	uc001udl.2	-	2	235	c.132C>T	c.(130-132)AAC>AAT	p.N44N		NM_024667	NP_078943	Q9H9H4	VP37B_HUMAN	vacuolar protein sorting 37B	44					cellular membrane organization|endosome transport|protein transport	late endosome membrane					0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.08e-05)|Epithelial(86;0.000197)|BRCA - Breast invasive adenocarcinoma(302;0.205)		TCATTTCTTTGTTAAGCTGAA	0.502		NaN											0	0	0	0.003163	0	15	45				
SBNO1	55206	broad.mit.edu	37	12	123815916	123815916	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:123815916C>T	uc010tap.1	-	7	916	c.916G>A	c.(916-918)GAA>AAA	p.E306K	SBNO1_uc010tao.1_Missense_Mutation_p.E305K|SBNO1_uc010taq.1_Intron|SBNO1_uc001uet.2_Missense_Mutation_p.E306K|SBNO1_uc001ueu.2_Missense_Mutation_p.E305K|SBNO1_uc001uev.2_Missense_Mutation_p.E304K|SBNO1_uc009zxy.1_Missense_Mutation_p.E271K	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	306							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		AGGAAAGTTTCATGTTGCTGA	0.363		NaN											0	0	0	0.010504	0	21	45				
MTMR6	9107	broad.mit.edu	37	13	25832777	25832777	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr13:25832777G>C	uc001uqf.3	-	7	1099	c.780C>G	c.(778-780)AAC>AAG	p.N260K	MTMR6_uc001uqe.1_Missense_Mutation_p.N260K	NM_004685	NP_004676	Q9Y217	MTMR6_HUMAN	myotubularin related protein 6	260	Myotubularin phosphatase.					cytoplasm|nuclear envelope	calcium-activated potassium channel activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			ovary(2)|skin(2)	4		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.00927)|Epithelial(112;0.0474)|OV - Ovarian serous cystadenocarcinoma(117;0.164)		TATTGGAATAGTTGTCTTCAT	0.294		NaN											0	0	0	0.004007	0	16	30				
AKAP11	11215	broad.mit.edu	37	13	42877222	42877222	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr13:42877222A>G	uc001uys.1	+	8	4515	c.4340A>G	c.(4339-4341)TAT>TGT	p.Y1447C		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	1447				LDPYRNEVSQLYSFSTSLVHSITKDA -> CGPSVELSPWK WQTRCGREGNSWKRE (in Ref. 5; BAA92117).	intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		CTGGATCCATATAGAAATGAG	0.388		NaN											0	0	0	0.007835	0	39	87				
RB1	5925	broad.mit.edu	37	13	49039203	49039203	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08			A	C	A	A		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr13:49039203A>C	uc001vcb.2	+	22	2447	c.2281A>C	c.(2281-2283)ATG>CTG	p.M761L		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	761	Pocket; binds T and E1A.|Domain B.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(8)|p.M761fs*4(1)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTCGGTCTTCATGCAGAGACT	0.333		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			0	0	0	0.006214	0	9	50		Valid		
FARP1	10160	broad.mit.edu	37	13	99020427	99020427	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr13:99020427C>T	uc001vnj.2	+	5	712	c.376C>T	c.(376-378)CAA>TAA	p.Q126*	FARP1_uc001vnh.2_Nonsense_Mutation_p.Q126*	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	126	FERM.				regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			TGACCACACACAACTCCAAGA	0.373		NaN											0	0	0	0.001168	0	6	38				
TNFSF13B	10673	broad.mit.edu	37	13	108922250	108922250	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr13:108922250G>C	uc001vqr.2	+	1	274	c.7G>C	c.(7-9)GAC>CAC	p.D3H	TNFSF13B_uc010agj.2_Missense_Mutation_p.D3H	NM_006573	NP_006564	Q9Y275	TN13B_HUMAN	tumor necrosis factor superfamily, member 13b	3	Cytoplasmic (Potential).				cell proliferation|immune response|signal transduction	extracellular space|integral to membrane|plasma membrane|soluble fraction	cytokine activity|tumor necrosis factor receptor binding				0	all_lung(23;0.000396)|all_neural(89;0.00256)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00902)|Lung SC(71;0.104)		all cancers(43;0.184)|BRCA - Breast invasive adenocarcinoma(86;0.19)			TGATATGGATGACTCCACAGA	0.443		NaN											0	0	0	0.006999	0	39	64				
RNASE7	84659	broad.mit.edu	37	14	21511342	21511342	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr14:21511342G>T	uc001vzk.3	+	2	448	c.191G>T	c.(190-192)CGG>CTG	p.R64L	NDRG2_uc010tll.1_Intron|RNASE7_uc001vzl.2_RNA	NM_032572	NP_115961	Q9H1E1	RNAS7_HUMAN	ribonuclease, RNase A family, 7 precursor	64					defense response to bacterium|innate immune response	extracellular region	nucleic acid binding|pancreatic ribonuclease activity			ovary(1)	1	all_cancers(95;0.000759)		OV - Ovarian serous cystadenocarcinoma(11;3.42e-11)|Epithelial(56;5.57e-09)|all cancers(55;2.36e-08)	GBM - Glioblastoma multiforme(265;0.0191)		CACACAAAACGGTGCAAAGAC	0.502		NaN											1	0	6.32553e-13	0.004656	6.89139e-13	25	80				
LRP10	26020	broad.mit.edu	37	14	23346425	23346425	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr14:23346425G>T	uc001whd.2	+	7	2384	c.1831G>T	c.(1831-1833)GAG>TAG	p.E611*	LRP10_uc001whe.2_Intron	NM_014045	NP_054764	Q7Z4F1	LRP10_HUMAN	low density lipoprotein receptor-related protein	611	Cytoplasmic (Potential).				endocytosis	coated pit|integral to membrane				central_nervous_system(1)	1	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.00549)		GCAAGATGGGGAGCAGGCACC	0.667		NaN											1	0	4.96729e-08	0.008871	5.30986e-08	21	58				
PRKD1	5587	broad.mit.edu	37	14	30098274	30098274	+	Silent	SNP	T	T	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr14:30098274T>C	uc001wqh.2	-	11	1879	c.1698A>G	c.(1696-1698)GTA>GTG	p.V566V		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	566					cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		GGCAATTTGATACTGAAATAC	0.299		NaN											0	0	0	0.004656	0	24	62				
COCH	1690	broad.mit.edu	37	14	31355167	31355167	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr14:31355167A>T	uc001wqr.2	+	11	1206	c.1126A>T	c.(1126-1128)AGC>TGC	p.S376C	COCH_uc001wqp.2_Missense_Mutation_p.S376C|COCH_uc001wqq.3_Missense_Mutation_p.S376C|uc001wqs.2_RNA|COCH_uc001wqt.1_Missense_Mutation_p.S227C	NM_004086	NP_004077	O43405	COCH_HUMAN	cochlin precursor	376	VWFA 2.				sensory perception of sound	proteinaceous extracellular matrix				pancreas(1)|central_nervous_system(1)|skin(1)	3	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.00645)		TGATGGCTCCAGCAGTGTTGG	0.438		NaN											0	0	0	0.009535	0	32	64				
NUBPL	80224	broad.mit.edu	37	14	32031321	32031321	+	Silent	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr14:32031321C>T	uc001wrk.3	+	2	211	c.156C>T	c.(154-156)ATC>ATT	p.I52I	NUBPL_uc010amj.2_RNA	NM_025152	NP_079428	Q8TB37	NUBPL_HUMAN	nucleotide binding protein-like	52					mitochondrial respiratory chain complex I assembly|mitochondrion morphogenesis	mitochondrion	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding				0	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.214)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0677)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0102)		GAACACAAATCATGTCCCGAG	0.398		NaN											0	0	0	0.001168	0	6	24				
MIA2	117153	broad.mit.edu	37	14	39716256	39716256	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr14:39716256C>A	uc001wux.2	+	4	672	c.478C>A	c.(478-480)CAG>AAG	p.Q160K	MIA2_uc010amy.1_Missense_Mutation_p.Q91K	NM_054024	NP_473365	Q96PC5	MIA2_HUMAN	melanoma inhibitory activity 2	160						extracellular region				ovary(1)|breast(1)	2	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0216)		AAGTGATTTTCAGATAGAACC	0.323		NaN											1	0	7.92952e-12	0.003954	8.55686e-12	26	53				
ZC3H14	79882	broad.mit.edu	37	14	89069337	89069337	+	Silent	SNP	C	C	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr14:89069337C>G	uc001xww.2	+	12	1905	c.1680C>G	c.(1678-1680)CTC>CTG	p.L560L	ZC3H14_uc010twd.1_Silent_p.L560L|ZC3H14_uc010twe.1_Silent_p.L560L|ZC3H14_uc001xwx.2_Intron|ZC3H14_uc010twf.1_Intron|ZC3H14_uc001xwy.2_Intron|ZC3H14_uc010twg.1_Intron|ZC3H14_uc001xxa.2_Silent_p.L105L|ZC3H14_uc001xxc.2_Intron|ZC3H14_uc001xxb.2_Intron	NM_024824	NP_079100	Q6PJT7	ZC3HE_HUMAN	zinc finger CCCH-type containing 14 isoform 1	560						cytoplasm|cytoplasm|nuclear speck	protein binding|RNA binding|zinc ion binding			ovary(2)|skin(1)	3						TCAGAGGTCTCCTCCACCCAC	0.512		NaN											0	0	0	0.00499	0	15	45				
GPR68	8111	broad.mit.edu	37	14	91700960	91700960	+	Silent	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr14:91700960G>A	uc001xzg.2	-	2	776	c.435C>T	c.(433-435)ATC>ATT	p.I145I	GPR68_uc001xzh.2_Silent_p.I155I	NM_003485	NP_003476	Q15743	OGR1_HUMAN	G protein-coupled receptor 68	145	Helical; Name=4; (Potential).				inflammatory response	integral to plasma membrane	G-protein coupled receptor activity			kidney(1)	1		all_cancers(154;0.0555)		COAD - Colon adenocarcinoma(157;0.21)		CCTTGGCCCAGATGACCACGC	0.627		NaN											0	0	0	0.006214	0	9	32				
NUDT14	256281	broad.mit.edu	37	14	105642983	105642983	+	Missense_Mutation	SNP	C	C	G	rs138979378		TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr14:105642983C>G	uc010tyn.1	-	4	430	c.316G>C	c.(316-318)GGC>CGC	p.G106R	NUDT14_uc001yqi.2_RNA	NM_177533	NP_803877	O95848	NUD14_HUMAN	nudix-type motif 14	106	Nudix hydrolase.					cytoplasm	metal ion binding|protein binding|UDP-sugar diphosphatase activity			skin(1)	1		all_cancers(154;0.0336)|all_epithelial(191;0.0729)|Melanoma(154;0.155)	OV - Ovarian serous cystadenocarcinoma(23;0.00989)|all cancers(16;0.0114)|Epithelial(46;0.0272)	Epithelial(152;0.047)|OV - Ovarian serous cystadenocarcinoma(161;0.148)|all cancers(159;0.208)		TCCACGAGGCCGGCACACAGC	0.677		NaN								HNSCC(42;0.11)			0	0	0	0.006122	0	19	60				
TJP1	7082	broad.mit.edu	37	15	30010801	30010801	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr15:30010801C>A	uc001zcr.2	-	21	4020	c.3545G>T	c.(3544-3546)GGG>GTG	p.G1182V	TJP1_uc010azl.2_Missense_Mutation_p.G1170V|TJP1_uc001zcq.2_Missense_Mutation_p.G1106V|TJP1_uc001zcs.2_Missense_Mutation_p.G1102V	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	1182					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		AGGCTTGGGCCCTGCTGAAGG	0.557		NaN											1	0	7.87624e-14	0.00278	8.69191e-14	23	66				
SLC12A6	9990	broad.mit.edu	37	15	34628777	34628777	+	Silent	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr15:34628777G>A	uc001zhw.2	-	1	269	c.105C>T	c.(103-105)CTC>CTT	p.L35L	SLC12A6_uc001zhx.2_Silent_p.L35L|SLC12A6_uc001zhy.2_RNA|SLC12A6_uc001zhz.2_RNA|SLC12A6_uc001zia.2_5'UTR|SLC12A6_uc001zib.2_Silent_p.L26L|SLC12A6_uc001zic.2_Silent_p.L35L|SLC12A6_uc010bau.2_Silent_p.L35L|SLC12A6_uc001zid.2_5'UTR	NM_133647	NP_598408	Q9UHW9	S12A6_HUMAN	solute carrier family 12, member 6 isoform a	35	Cytoplasmic (Potential).				angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|ovary(1)|skin(1)	7		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	ATCGAGAGCTGAGGTCCGGAC	0.527		NaN											0	0	0	0.006122	0	14	54				
MFAP1	4236	broad.mit.edu	37	15	44109632	44109632	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr15:44109632C>T	uc001zth.1	-	2	278	c.94G>A	c.(94-96)GAA>AAA	p.E32K		NM_005926	NP_005917	P55081	MFAP1_HUMAN	microfibrillar-associated protein 1	32						microfibril				skin(1)	1		all_cancers(109;7.57e-15)|all_epithelial(112;3.51e-12)|Lung NSC(122;4.72e-08)|all_lung(180;4.9e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.33e-07)		TTCACTTTTTCCATTGAAATC	0.433		NaN											0	0	0	0.008361	0	28	68				
SECISBP2L	9728	broad.mit.edu	37	15	49320761	49320761	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr15:49320761C>G	uc001zxe.1	-	5	917	c.783G>C	c.(781-783)CAG>CAC	p.Q261H	SECISBP2L_uc001zxd.1_Missense_Mutation_p.Q261H|SECISBP2L_uc010bep.1_Missense_Mutation_p.Q23H|SECISBP2L_uc010beq.1_Intron	NM_014701	NP_055516	Q93073	SBP2L_HUMAN	SECIS binding protein 2-like	261										breast(1)|skin(1)	2						CACTAGCCCCCTGCTCACTAG	0.512		NaN											0	0	0	0.008361	0	31	87				
VPS13C	54832	broad.mit.edu	37	15	62182381	62182381	+	Silent	SNP	G	G	A	rs113570828		TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr15:62182381G>A	uc002agz.2	-	67	9398	c.9324C>T	c.(9322-9324)TCC>TCT	p.S3108S	VPS13C_uc002aha.2_Silent_p.S3065S|VPS13C_uc002ahb.1_Silent_p.S3108S|VPS13C_uc002ahc.1_Silent_p.S3065S	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	3108					protein localization					ovary(2)	2						TCCCAATATAGGAAACTTCCT	0.373		NaN											0	0	0	0.008871	0	19	50				
RAB8B	51762	broad.mit.edu	37	15	63541870	63541870	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr15:63541870G>A	uc002alz.2	+	3	308	c.212G>A	c.(211-213)CGA>CAA	p.R71Q	RAB8B_uc010uih.1_Missense_Mutation_p.R71Q	NM_016530	NP_057614	Q92930	RAB8B_HUMAN	RAB8B, member RAS oncogene family	71					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity			ovary(1)|kidney(1)	2						GAAAGATTCCGAACAATCACG	0.448		NaN											0	0	0	0.010729	0	9	25				
HERC1	8925	broad.mit.edu	37	15	63970149	63970149	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr15:63970149C>G	uc002amp.2	-	37	7113	c.6965G>C	c.(6964-6966)CGG>CCG	p.R2322P		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	2322					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						GTGAACACACCGACCTCCAAC	0.557		NaN											0	0	0	0.010818	0	31	91				
KIAA1024	23251	broad.mit.edu	37	15	79750750	79750750	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr15:79750750C>T	uc002bew.1	+	2	2336	c.2261C>T	c.(2260-2262)CCA>CTA	p.P754L	KIAA1024_uc010unk.1_Missense_Mutation_p.P754L	NM_015206	NP_056021	Q9UPX6	K1024_HUMAN	hypothetical protein LOC23251	754						integral to membrane				pancreas(2)|ovary(1)|central_nervous_system(1)	4						GACACAGGCCCAGGAGATAAT	0.453		NaN											0	0	0	0.006122	0	17	63				
SELS	55829	broad.mit.edu	37	15	101813019	101813019	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr15:101813019C>T	uc010use.1	-	6	605	c.527G>A	c.(526-528)TGG>TAG	p.W176*	SELS_uc010usf.1_Nonsense_Mutation_p.W176*	NM_203472	NP_982298	Q9BQE4	SELS_HUMAN	selenoprotein S	176					anti-apoptosis|cell redox homeostasis|cellular response to insulin stimulus|cellular response to lipopolysaccharide|cellular response to oxidative stress|endoplasmic reticulum unfolded protein response|ER overload response|ER-associated protein catabolic process|negative regulation of acute inflammatory response to antigenic stimulus|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of interleukin-6 production|negative regulation of nitric-oxide synthase biosynthetic process|negative regulation of tumor necrosis factor production|regulation of gluconeogenesis|regulation of nitric oxide metabolic process|response to glucose stimulus|response to redox state|retrograde protein transport, ER to cytosol	integral to endoplasmic reticulum membrane|low-density lipoprotein particle|microsome|plasma membrane|very-low-density lipoprotein particle	antioxidant activity|enzyme binding|receptor activity|selenium binding				0	Lung NSC(78;0.00156)|all_lung(78;0.00195)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00113)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TCCAGGTCTCCAGGAGCAAGC	0.478		NaN											0	0	0	0.000602	0	5	13				
CACNA1H	8912	broad.mit.edu	37	16	1248648	1248648	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr16:1248648C>T	uc002cks.2	+	6	925	c.677C>T	c.(676-678)ACG>ATG	p.T226M	CACNA1H_uc002ckt.2_Missense_Mutation_p.T226M	NM_021098	NP_066921	O95180	CAC1H_HUMAN	calcium channel, voltage-dependent, T type,	226	Cytoplasmic (Potential).|I.				aldosterone biosynthetic process|axon guidance|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|muscle contraction|myoblast fusion|positive regulation of acrosome reaction|regulation of heart contraction	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(2)	2		Hepatocellular(780;0.00369)			Flunarizine(DB04841)|Mibefradil(DB01388)	ctgctggatacgctgcccatg	0.478		NaN											0	0	0	0.009718	0	40	70				
MRPS34	65993	broad.mit.edu	37	16	1822451	1822451	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr16:1822451G>C	uc002cmo.2	-	3	448	c.428C>G	c.(427-429)CCC>CGC	p.P143R	NME3_uc002cmm.2_5'Flank|NME3_uc010brv.2_5'Flank|MRPS34_uc002cmn.2_Missense_Mutation_p.P9R|MRPS34_uc002cmp.1_Missense_Mutation_p.P150R|EME2_uc002cmq.1_5'Flank|EME2_uc010brw.1_5'Flank	NM_023936	NP_076425	P82930	RT34_HUMAN	mitochondrial ribosomal protein S34	143						mitochondrion|ribosome	protein binding			skin(2)	2						CTCGTGCTTGGGCACCAGCCG	0.627		NaN											0	0	0	0.004289	0	33	114				
ZSCAN10	84891	broad.mit.edu	37	16	3139752	3139752	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr16:3139752C>G	uc002ctv.1	-	5	1606	c.1518G>C	c.(1516-1518)CAG>CAC	p.Q506H	ZSCAN10_uc002cty.1_Missense_Mutation_p.Q167H|ZSCAN10_uc002ctw.1_Missense_Mutation_p.Q424H|ZSCAN10_uc002ctx.1_Missense_Mutation_p.Q434H	NM_032805	NP_116194	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	506	C2H2-type 7.				negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						GCTGCGAGCTCTGCGTGAAGC	0.716		NaN											0	0	0	0.001984	0	7	4				
CREBBP	1387	broad.mit.edu	37	16	3788651	3788651	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr16:3788651C>G	uc002cvv.2	-	26	4507	c.4303G>C	c.(4303-4305)GAT>CAT	p.D1435H	CREBBP_uc002cvw.2_Missense_Mutation_p.D1397H	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1435	Cys/His-rich.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding	p.D1435G(1)|p.D1435E(1)		haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TGAATACTATCCAGATAAGAA	0.433		NaN	T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				0	0	0	0.010729	0	12	19		Valid		
NMRAL1	57407	broad.mit.edu	37	16	4511813	4511813	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr16:4511813C>A	uc002cwm.2	-	6	1024	c.868G>T	c.(868-870)GAA>TAA	p.E290*	NMRAL1_uc002cwn.2_Nonsense_Mutation_p.E290*|NMRAL1_uc002cwo.2_Nonsense_Mutation_p.E290*|NMRAL1_uc002cwp.2_Nonsense_Mutation_p.E326*	NM_020677	NP_065728	Q9HBL8	NMRL1_HUMAN	NmrA-like family domain containing 1	290						nucleus|perinuclear region of cytoplasm	binding			kidney(1)	1						TTGTGCTGTTCCAGCCACTGG	0.622		NaN											1	0	5.20006e-24	0.011902	5.91074e-24	46	81				
SEZ6L2	26470	broad.mit.edu	37	16	29908193	29908193	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr16:29908193G>A	uc002duq.3	-	3	701	c.461C>T	c.(460-462)ACG>ATG	p.T154M	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|SEZ6L2_uc002dup.3_Missense_Mutation_p.T84M|SEZ6L2_uc002dur.3_Missense_Mutation_p.T84M|SEZ6L2_uc002dus.3_Missense_Mutation_p.T154M|SEZ6L2_uc010vec.1_Missense_Mutation_p.T154M|SEZ6L2_uc010ved.1_Missense_Mutation_p.T110M	NM_201575	NP_963869	Q6UXD5	SE6L2_HUMAN	seizure related 6 homolog (mouse)-like 2 isoform	154	Thr-rich.|Extracellular (Potential).					endoplasmic reticulum membrane|integral to membrane|plasma membrane				ovary(1)|skin(1)	2						GATGGTGGTCGTCGTCTCCTC	0.672		NaN											0	0	0	0.005443	0	21	43				
VPS35	55737	broad.mit.edu	37	16	46705699	46705699	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr16:46705699G>A	uc002eef.3	-	12	1541	c.1442C>T	c.(1441-1443)CCA>CTA	p.P481L	VPS35_uc002eed.2_Missense_Mutation_p.P302L|VPS35_uc002eee.2_Missense_Mutation_p.P442L	NM_018206	NP_060676	Q96QK1	VPS35_HUMAN	vacuolar protein sorting 35	481					protein transport|retrograde transport, endosome to Golgi	cytosol|endosome|membrane	protein binding				0		all_cancers(37;7.65e-05)|all_epithelial(9;0.000154)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				AAAATCTTCTGGATCAGGGTC	0.483		NaN											0	0	0	0.003163	0	16	33				
ABCC11	85320	broad.mit.edu	37	16	48244929	48244929	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr16:48244929G>A	uc002eff.1	-	10	1888	c.1538C>T	c.(1537-1539)GCC>GTC	p.A513V	ABCC11_uc002efg.1_Missense_Mutation_p.A513V|ABCC11_uc002efh.1_Missense_Mutation_p.A513V|ABCC11_uc010vgk.1_RNA	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	513	ABC transporter 1.|Cytoplasmic (Potential).					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				TGGCCCGAGGGCATCTCTAGG	0.607		NaN							Cerumen_Type				0	0	0	0.007413	0	20	54				
SLC12A3	6559	broad.mit.edu	37	16	56921870	56921870	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr16:56921870C>G	uc010ccm.2	+	18	2241	c.2212C>G	c.(2212-2214)CTG>GTG	p.L738V	SLC12A3_uc002ekd.3_Missense_Mutation_p.L738V|SLC12A3_uc010ccn.2_Missense_Mutation_p.L737V	NM_001126108	NP_001119580	P55017	S12A3_HUMAN	solute carrier family 12, member 3 isoform 3	738	Cytoplasmic (Potential).		L -> R (in GS).		sodium ion transmembrane transport	apical plasma membrane|integral to plasma membrane|membrane fraction	sodium:chloride symporter activity			ovary(2)|breast(1)	3					Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Diazoxide(DB01119)|Hydrochlorothiazide(DB00999)|Metolazone(DB00524)|Polythiazide(DB01324)|Quinethazone(DB01325)	GCCCAACATTCTGGTGGTTGG	0.602		NaN											0	0	0	0.012319	0	20	44				
CDH16	1014	broad.mit.edu	37	16	66944399	66944399	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr16:66944399G>C	uc002eql.2	-	15	2004	c.1931C>G	c.(1930-1932)CCG>CGG	p.P644R	CDH16_uc010cdy.2_Intron|CDH16_uc002eqm.2_Missense_Mutation_p.P547R	NM_004062	NP_004053	O75309	CAD16_HUMAN	cadherin 16 precursor	644	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		GCTCAGTCTCGGCTCATCTGC	0.652		NaN											0	0	0	0.005443	0	26	48				
FBXL8	55336	broad.mit.edu	37	16	67197579	67197579	+	Silent	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr16:67197579C>T	uc002erj.1	+	3	1101	c.981C>T	c.(979-981)TGC>TGT	p.C327C	FBXL8_uc002erk.1_Silent_p.C327C|HSF4_uc002erl.1_5'UTR|HSF4_uc002erm.1_5'UTR|HSF4_uc002ern.1_5'Flank|HSF4_uc010cec.1_5'Flank	NM_018378	NP_060848	Q96CD0	FBXL8_HUMAN	F-box and leucine-rich repeat protein 8	327							protein binding				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0144)|Epithelial(162;0.0338)|all cancers(182;0.185)		CGGCGCGCTGCGCGGCCCTGC	0.716		NaN											0	0	0	0.006214	0	10	14				
NFAT5	10725	broad.mit.edu	37	16	69726188	69726188	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr16:69726188A>C	uc002exm.1	+	12	3614	c.2406A>C	c.(2404-2406)TTA>TTC	p.L802F	NFAT5_uc002exi.2_Missense_Mutation_p.L726F|NFAT5_uc002exj.1_Missense_Mutation_p.L726F|NFAT5_uc002exk.1_Missense_Mutation_p.L726F|NFAT5_uc002exl.1_Missense_Mutation_p.L820F|NFAT5_uc002exn.1_Missense_Mutation_p.L819F|NFAT5_uc002exo.1_5'Flank	NM_006599	NP_006590	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5 isoform c	802					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						AACAAGTTTTAGAGGCACAGC	0.438		NaN											0	0	0	0.007291	0	29	119				
ZNF276	92822	broad.mit.edu	37	16	89789221	89789221	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr16:89789221G>C	uc002fos.3	+	2	585	c.488G>C	c.(487-489)GGT>GCT	p.G163A	C16orf7_uc002fom.1_5'Flank|ZNF276_uc010ciq.2_5'UTR|ZNF276_uc002fop.2_Missense_Mutation_p.G88A|ZNF276_uc002foq.3_Missense_Mutation_p.G88A|ZNF276_uc010cir.2_RNA|ZNF276_uc002for.3_5'UTR|ZNF276_uc010cis.2_5'UTR|ZNF276_uc002fot.3_RNA|ZNF276_uc010vpm.1_5'Flank|ZNF276_uc010cit.1_5'Flank	NM_001113525	NP_001106997	Q8N554	ZN276_HUMAN	zinc finger protein 276 isoform a	163					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		TCCCCGGCTGGTCGCCGGAAG	0.592		NaN											0	0	0	0.004007	0	17	59				
OR3A1	4994	broad.mit.edu	37	17	3194930	3194930	+	Nonstop_Mutation	SNP	C	C	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr17:3194930C>G	uc002fvh.1	-	1	947	c.947G>C	c.(946-948)TGA>TCA	p.*316S		NM_002550	NP_002541	P47881	OR3A1_HUMAN	olfactory receptor, family 3, subfamily A,	316					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(2)|central_nervous_system(1)	3						GAGACCTCCTCAAGCCAGTGA	0.473		NaN											0	0	0	0.001855	0	13	56				
ZZEF1	23140	broad.mit.edu	37	17	3957435	3957435	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr17:3957435C>T	uc002fxe.2	-	34	5414	c.5350G>A	c.(5350-5352)GAT>AAT	p.D1784N	ZZEF1_uc002fxh.2_Missense_Mutation_p.D98N|ZZEF1_uc002fxi.2_Missense_Mutation_p.D19N|ZZEF1_uc002fxj.1_Missense_Mutation_p.D397N	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	1784	ZZ-type 1.						calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TCACACCCATCACAAGAGATG	0.438		NaN											0	0	0	0.003163	0	16	77				
CHRNE	1145	broad.mit.edu	37	17	4805975	4805975	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr17:4805975C>T	uc002fzk.1	-	2	141	c.130G>A	c.(130-132)GAG>AAG	p.E44K	C17orf107_uc002fzl.3_3'UTR	NM_000080	NP_000071	Q04844	ACHE_HUMAN	nicotinic acetylcholine receptor epsilon	44	Extracellular (Potential).				muscle contraction|synaptic transmission, cholinergic	cell junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity				0						TCCTCAGGCTCCCGCACTGGC	0.542		NaN											0	0	0	0.01441	0	60	109				
TP53	7157	broad.mit.edu	37	17	7577079	7577079	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr17:7577079C>A	uc002gim.2	-	8	1053	c.859G>T	c.(859-861)GAG>TAG	p.E287*	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Nonsense_Mutation_p.E287*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.E155*|TP53_uc010cng.1_Nonsense_Mutation_p.E155*|TP53_uc002gii.1_Nonsense_Mutation_p.E155*|TP53_uc010cnh.1_Nonsense_Mutation_p.E287*|TP53_uc010cni.1_Nonsense_Mutation_p.E287*|TP53_uc002gij.2_Nonsense_Mutation_p.E287*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	287	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> V (in sporadic cancers; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> A (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.N288fs*13(17)|p.E287*(8)|p.0?(7)|p.E287K(6)|p.E287E(5)|p.E287G(2)|p.E287D(2)|p.?(2)|p.R283fs*16(2)|p.E286fs*17(2)|p.E285_N288delEEEN(1)|p.E287V(1)|p.E287fs*17(1)|p.E287A(1)|p.R282_E287delRRTEEE(1)|p.T284_G293del10(1)|p.E285fs*13(1)|p.L265_K305del41(1)|p.T284fs*57(1)|p.R283fs*56(1)|p.V272_K292del21(1)|p.E285_L289delEEENL(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGGAGATTCTCTTCCTCTGTG	0.567		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			1	0	3.62473e-10	0.012319	3.89916e-10	22	21		Valid		
NCOR1	9611	broad.mit.edu	37	17	15973488	15973488	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08			T	A	T	T		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr17:15973488T>A	uc002gpo.2	-	31	4744	c.4504A>T	c.(4504-4506)ACT>TCT	p.T1502S	NCOR1_uc002gpn.2_Missense_Mutation_p.T1518S|NCOR1_uc002gpp.1_Missense_Mutation_p.T1409S|NCOR1_uc002gpm.2_5'Flank|NCOR1_uc010vwb.1_Missense_Mutation_p.T86S|NCOR1_uc010coy.2_Missense_Mutation_p.T410S|NCOR1_uc010vwc.1_Missense_Mutation_p.T313S	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	1502	Interaction with ETO.|Interaction with C1D (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CCATCAGAAGTTCTGTTCATC	0.383		NaN											0	0	0	0.00623	0	36	151		Valid		
TOP3A	7156	broad.mit.edu	37	17	18181485	18181485	+	Silent	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr17:18181485G>A	uc002gsx.1	-	18	2560	c.2331C>T	c.(2329-2331)AAC>AAT	p.N777N	TOP3A_uc010cpz.1_Silent_p.N229N|TOP3A_uc010vxr.1_Silent_p.N307N|TOP3A_uc002gsw.1_Silent_p.N229N|TOP3A_uc010vxs.1_Silent_p.N675N	NM_004618	NP_004609	Q13472	TOP3A_HUMAN	topoisomerase (DNA) III alpha	777					DNA topological change|meiosis	chromosome|PML body	ATP binding|DNA topoisomerase type I activity|protein binding|zinc ion binding			skin(3)	3						GGTGCTGGCTGTTGTCCATCC	0.632		NaN											0	0	0	0.012319	0	20	92				
TRIM16L	147166	broad.mit.edu	37	17	18638504	18638504	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr17:18638504T>A	uc002gug.1	+	10	1465	c.778T>A	c.(778-780)TTC>ATC	p.F260I	TRIM16L_uc010vyf.1_Missense_Mutation_p.F314I|TRIM16L_uc002guh.1_Missense_Mutation_p.F260I|TRIM16L_uc010cqg.1_Missense_Mutation_p.F362I|TRIM16L_uc002gui.1_Missense_Mutation_p.F260I|TRIM16L_uc010vyg.1_Missense_Mutation_p.F260I|TRIM16L_uc010vyh.1_3'UTR	NM_001037330	NP_001032407	Q309B1	TR16L_HUMAN	tripartite motif-containing 16-like	260	B30.2/SPRY.					cytoplasm					0						CGGGAAGGAGTTCACGGCCTG	0.557		NaN											0	0	0	0.00499	0	13	82				
FBXL20	84961	broad.mit.edu	37	17	37427047	37427047	+	Splice_Site	SNP	A	A	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr17:37427047A>T	uc010wed.1	-	11	1109	c.888_splice	c.e11+1	p.R296_splice	FBXL20_uc002hrt.2_Splice_Site_p.R296_splice|FBXL20_uc010cvu.2_Splice_Site_p.R264_splice	NM_032875	NP_116264	Q96IG2	FXL20_HUMAN	F-box and leucine-rich repeat protein 20							cytoplasm				ovary(1)	1			LUAD - Lung adenocarcinoma(14;0.146)			GAAAATACTTACCCTGGCTAG	0.358		NaN											0	0	0	0.008871	0	17	17				
KIAA1267	284058	broad.mit.edu	37	17	44248600	44248600	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr17:44248600G>C	uc002ikb.2	-	1	995	c.910C>G	c.(910-912)CGC>GGC	p.R304G	KIAA1267_uc002ikc.2_Missense_Mutation_p.R304G|KIAA1267_uc002ikd.2_Missense_Mutation_p.R304G|KIAA1267_uc010dav.2_Missense_Mutation_p.R304G	NM_015443	NP_056258	Q7Z3B3	K1267_HUMAN	hypothetical protein LOC284058	304	Potential.					MLL1 complex	protein binding			skin(2)	2		Melanoma(429;0.211)				ACCTGTAAGCGCTTTTGTAAT	0.468		NaN											0	0	0	0.014323	0	23	143				
TLK2	11011	broad.mit.edu	37	17	60654136	60654136	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr17:60654136G>C	uc010ddp.2	+	14	1522	c.1254G>C	c.(1252-1254)AAG>AAC	p.K418N	TLK2_uc002izx.3_Missense_Mutation_p.K244N|TLK2_uc002izz.3_Missense_Mutation_p.K396N|TLK2_uc002jaa.3_Missense_Mutation_p.K364N|TLK2_uc010wpd.1_Missense_Mutation_p.K364N	NM_006852	NP_006843	Q86UE8	TLK2_HUMAN	tousled-like kinase 2 isoform A	418	Potential.				cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|kidney(1)	2						ATCTTAAAAAGGTAAGTATAA	0.343		NaN											0	0	0	0.01441	0	59	40				
PRKCA	5578	broad.mit.edu	37	17	64299005	64299005	+	Silent	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr17:64299005G>A	uc002jfp.1	+	1	80	c.36G>A	c.(34-36)GCG>GCA	p.A12A	PRKCA_uc002jfo.1_5'UTR	NM_002737	NP_002728	P17252	KPCA_HUMAN	protein kinase C, alpha	12					activation of phospholipase C activity|energy reserve metabolic process|induction of apoptosis by extracellular signals|intracellular signal transduction|mRNA metabolic process|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of blood vessel endothelial cell migration|regulation of insulin secretion|response to interleukin-1|synaptic transmission	cytosol|endoplasmic reticulum|membrane fraction|nucleoplasm|plasma membrane	ATP binding|enzyme binding|histone kinase activity (H3-T6 specific)|protein kinase C activity|zinc ion binding			central_nervous_system(4)|large_intestine(1)|stomach(1)|lung(1)|breast(1)|ovary(1)	9			BRCA - Breast invasive adenocarcinoma(6;4.68e-09)		Phosphatidylserine(DB00144)|Vitamin E(DB00163)	ACTCCACGGCGTCTCAGGACG	0.602		NaN											0	0	0	0.006122	0	19	27				
CASKIN2	57513	broad.mit.edu	37	17	73498037	73498037	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr17:73498037C>T	uc002joc.2	-	18	3668	c.3118G>A	c.(3118-3120)GAG>AAG	p.E1040K	CASKIN2_uc010wsc.1_Missense_Mutation_p.E958K	NM_020753	NP_065804	Q8WXE0	CSKI2_HUMAN	cask-interacting protein 2 isoform a	1040	Pro-rich.					cytoplasm				pancreas(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.78e-10)|Breast(9;5.8e-10)|all_lung(278;0.246)		all cancers(21;4.57e-07)|Epithelial(20;2.92e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CTGCTGGGCTCGGGCTGGGGA	0.697		NaN											0	0	0	0.007291	0	29	57				
ARHGAP28	79822	broad.mit.edu	37	18	6890047	6890047	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr18:6890047T>A	uc010wzi.1	+	12	1404	c.1166T>A	c.(1165-1167)ATC>AAC	p.I389N	ARHGAP28_uc002knc.2_Missense_Mutation_p.I514N|ARHGAP28_uc002knd.2_Missense_Mutation_p.I407N|ARHGAP28_uc002kne.2_Missense_Mutation_p.I407N|ARHGAP28_uc002knf.2_Missense_Mutation_p.I398N			B4DXL2	B4DXL2_HUMAN	SubName: Full=Putative uncharacterized protein ARHGAP28;	389					signal transduction	intracellular				pancreas(1)	1		Colorectal(10;0.168)				GCCCACATCATCCGCCTAATG	0.443		NaN											0	0	0	0.01441	0	47	98				
ANKRD29	147463	broad.mit.edu	37	18	21226188	21226188	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr18:21226188C>T	uc002kun.2	-	3	353	c.196G>A	c.(196-198)GTT>ATT	p.V66I	ANKRD29_uc002kuo.2_Missense_Mutation_p.V66I	NM_173505	NP_775776	Q8N6D5	ANR29_HUMAN	ankyrin repeat domain 29	66	ANK 2.									ovary(3)|breast(1)	4	all_cancers(21;5.07e-05)|all_epithelial(16;2.49e-07)|Lung NSC(20;0.00211)|all_lung(20;0.00676)|Colorectal(14;0.0202)|Ovarian(20;0.127)					CCTTGCAGAACCAGTTCCCTC	0.498		NaN											0	0	0	0.004007	0	15	43				
KLHL14	57565	broad.mit.edu	37	18	30350174	30350174	+	Silent	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr18:30350174C>T	uc002kxm.1	-	2	769	c.381G>A	c.(379-381)CTG>CTA	p.L127L		NM_020805	NP_065856	Q9P2G3	KLH14_HUMAN	kelch-like 14	127	BTB.					cytosol|endoplasmic reticulum membrane				ovary(1)	1						AGCAGCCCTGCAGCACCAGGT	0.587		NaN											0	0	0	0.011902	0	38	118				
NEDD4L	23327	broad.mit.edu	37	18	56033354	56033354	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr18:56033354G>A	uc002lgy.2	+	21	2231	c.1957G>A	c.(1957-1959)GAA>AAA	p.E653K	NEDD4L_uc002lgz.2_Missense_Mutation_p.E589K|NEDD4L_uc002lgx.2_Missense_Mutation_p.E633K|NEDD4L_uc010xee.1_Missense_Mutation_p.E532K|NEDD4L_uc002lhc.2_Missense_Mutation_p.E645K|NEDD4L_uc002lhd.2_Missense_Mutation_p.E532K|NEDD4L_uc002lhb.2_Missense_Mutation_p.E512K|NEDD4L_uc002lhe.2_Missense_Mutation_p.E625K|NEDD4L_uc002lhf.2_Missense_Mutation_p.E512K|NEDD4L_uc002lhg.2_Missense_Mutation_p.E532K|NEDD4L_uc002lhh.2_Missense_Mutation_p.E428K|NEDD4L_uc010dpn.2_5'UTR	NM_001144967	NP_001138439	Q96PU5	NED4L_HUMAN	neural precursor cell expressed, developmentally	653	HECT.				cellular sodium ion homeostasis|excretion|interspecies interaction between organisms|positive regulation of endocytosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein catabolic process|response to metal ion|sodium ion transport|water homeostasis	cytoplasm	protein binding|sodium channel regulator activity|ubiquitin-protein ligase activity			lung(4)	4						GATTGAGTTTGAATCAGAGAA	0.418		NaN											0	0	0	0.013537	0	12	13				
RTTN	25914	broad.mit.edu	37	18	67860668	67860668	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr18:67860668G>A	uc002lkp.2	-	8	931	c.863C>T	c.(862-864)TCT>TTT	p.S288F	RTTN_uc002lko.2_RNA|RTTN_uc010xfb.1_5'UTR|RTTN_uc002lkq.1_Missense_Mutation_p.S288F	NM_173630	NP_775901	Q86VV8	RTTN_HUMAN	rotatin	288							binding			ovary(3)|pancreas(2)|skin(1)|breast(1)|central_nervous_system(1)	8		Esophageal squamous(42;0.129)				ATAAGACAAAGAAGAATTTTG	0.418		NaN											0	0	0	0.003163	0	14	42				
C19orf25	148223	broad.mit.edu	37	19	1475148	1475148	+	Silent	SNP	G	G	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:1475148G>T	uc002lsy.3	-	2	455	c.240C>A	c.(238-240)GGC>GGA	p.G80G	C19orf25_uc010xgn.1_Intron|C19orf25_uc010dsk.2_Silent_p.G80G|C19orf25_uc010xgo.1_Silent_p.G120G|C19orf25_uc002lsx.1_3'UTR	NM_152482	NP_689695	Q9UFG5	CS025_HUMAN	hypothetical protein LOC148223	80							protein binding				0		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCAGCACGTTGCCCGCCTGCT	0.672		NaN											1	0	0.00198382	0.001984	0.00201935	7	4				
PTPRS	5802	broad.mit.edu	37	19	5258028	5258028	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:5258028C>T	uc002mbv.2	-	8	940	c.706G>A	c.(706-708)GAG>AAG	p.E236K	PTPRS_uc002mbu.1_Missense_Mutation_p.V227I|PTPRS_uc010xin.1_Missense_Mutation_p.V227I|PTPRS_uc002mbw.2_Missense_Mutation_p.V227I|PTPRS_uc002mbx.2_Missense_Mutation_p.E227K|PTPRS_uc002mby.2_Missense_Mutation_p.V227I	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	236	Extracellular (Potential).				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		CGTTCCCTACCTCGCACGTAG	0.662		NaN											0	0	0	0.010818	0	32	59				
RPL36	25873	broad.mit.edu	37	19	5691448	5691448	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:5691448A>C	uc002mcv.2	+	3	281	c.212A>C	c.(211-213)AAA>ACA	p.K71T	RPL36_uc002mcw.2_Missense_Mutation_p.K71T	NM_033643	NP_378669	Q9Y3U8	RL36_HUMAN	ribosomal protein L36	71					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|structural constituent of ribosome				0						CGGGCCCTCAAATTTATCAAG	0.647		NaN									OREG0025183	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003954	0	26	67				
NRTN	4902	broad.mit.edu	37	19	5824219	5824219	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:5824219A>G	uc002mde.2	+	1	402	c.43A>G	c.(43-45)AGC>GGC	p.S15G		NM_004558	NP_004549	Q99748	NRTN_HUMAN	neurturin preproprotein	15					axon guidance|MAPKKK cascade|neural crest cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular region	growth factor activity				0						AGTGCTCTGCAGCTCCGTGCT	0.697		NaN											0	0	0	0.001168	0	6	17				
MCOLN1	57192	broad.mit.edu	37	19	7592790	7592790	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:7592790A>G	uc002mgo.2	+	6	846	c.721A>G	c.(721-723)AAC>GAC	p.N241D	MCOLN1_uc002mgp.2_Missense_Mutation_p.N206D	NM_020533	NP_065394	Q9GZU1	MCLN1_HUMAN	mucolipin 1	241					calcium ion transport|cellular iron ion homeostasis|transferrin transport	integral to plasma membrane|late endosome membrane|lysosomal membrane	cation channel activity|iron ion transmembrane transporter activity			breast(1)	1						GAAGACCATTAACCTCCAGAG	0.612		NaN											0	0	0	0.003163	0	14	48				
MUC16	94025	broad.mit.edu	37	19	9086960	9086960	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:9086960C>G	uc002mkp.2	-	1	5059	c.4855G>C	c.(4855-4857)GAG>CAG	p.E1619Q		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	1619	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GGGCCAGTCTCAATCTCTCTG	0.512		NaN											0	0	0	0.01441	0	57	117				
STX10	8677	broad.mit.edu	37	19	13255242	13255242	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:13255242G>C	uc010xnb.1	-	8	732	c.732C>G	c.(730-732)ATC>ATG	p.I244M	STX10_uc002mwn.2_3'UTR|STX10_uc002mwo.2_3'UTR|STX10_uc010xna.1_RNA|STX10_uc010xnc.1_Missense_Mutation_p.I145M	NM_003765	NP_003756	O60499	STX10_HUMAN	syntaxin 10	244	Helical; Anchor for type IV membrane protein; (Potential).				Golgi vesicle transport|intracellular protein transport|retrograde transport, endosome to Golgi	Golgi membrane|integral to membrane	SNAP receptor activity				0			OV - Ovarian serous cystadenocarcinoma(19;3.41e-21)			AGAATAGTAAGATGAGAACGA	0.627		NaN											0	0	0	0.001984	0	7	10				
C19orf57	79173	broad.mit.edu	37	19	14000223	14000223	+	Silent	SNP	C	C	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:14000223C>G	uc002mxl.1	-	6	1505	c.1446G>C	c.(1444-1446)GTG>GTC	p.V482V	C19orf57_uc002mxk.1_Silent_p.V364V|C19orf57_uc002mxm.1_Intron	NM_024323	NP_077299	Q0VDD7	CS057_HUMAN	hypothetical protein LOC79173	482					multicellular organismal development		protein binding			ovary(2)|upper_aerodigestive_tract(1)	3			OV - Ovarian serous cystadenocarcinoma(19;2e-21)			TGTGTTCCAGCACAACAGAGG	0.622		NaN											0	0	0	0.003954	0	25	71				
DPY19L3	147991	broad.mit.edu	37	19	32930033	32930033	+	Silent	SNP	A	A	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:32930033A>G	uc002ntg.2	+	7	788	c.612A>G	c.(610-612)AGA>AGG	p.R204R	DPY19L3_uc002nth.1_Silent_p.R204R|DPY19L3_uc002nti.1_RNA	NM_207325	NP_997208	Q6ZPD9	D19L3_HUMAN	dpy-19-like 3	204						integral to membrane				ovary(4)	4	Esophageal squamous(110;0.162)					ATACCACAAGAGTTGAGTTTA	0.393		NaN											0	0	0	0.01441	0	55	91				
CHST8	64377	broad.mit.edu	37	19	34180217	34180217	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:34180217T>A	uc002nus.3	+	3	555	c.50T>A	c.(49-51)ATC>AAC	p.I17N	CHST8_uc002nut.3_Missense_Mutation_p.I17N|CHST8_uc002nuu.2_Missense_Mutation_p.I17N	NM_001127895	NP_001121367	Q9H2A9	CHST8_HUMAN	carbohydrate (N-acetylgalactosamine 4-0)	17	Helical; Signal-anchor for type II membrane protein; (Potential).				carbohydrate biosynthetic process|central nervous system development|hormone biosynthetic process|proteoglycan biosynthetic process|sulfur compound metabolic process	Golgi membrane|integral to membrane	N-acetylgalactosamine 4-O-sulfotransferase activity			skin(2)|large_intestine(1)|ovary(1)	4	Esophageal squamous(110;0.162)					TTCTCTTCCATCCTGCTGTTC	0.647		NaN											0	0	0	0.003954	0	27	134				
ZNF529	57711	broad.mit.edu	37	19	37045699	37045699	+	Splice_Site	SNP	C	C	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:37045699C>A	uc002oeh.3	-	4	311	c.109_splice	c.e4-1	p.E37_splice	ZNF529_uc010xth.1_Splice_Site_p.E37_splice|ZNF529_uc010xti.1_Splice_Site_p.E19_splice|ZNF529_uc002oeg.3_Splice_Site	NM_020951	NP_066002	Q6P280	ZN529_HUMAN	zinc finger protein 529 isoform a						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1	Esophageal squamous(110;0.198)					TCACCAGTTCCTGAAACAACA	0.413		NaN											1	0	0.000602214	0.000602	0.000622288	4	7				
RYR1	6261	broad.mit.edu	37	19	38939069	38939070	+	Missense_Mutation	DNP	TC	TC	AA			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:38939069_38939070TC>AA	uc002oit.2	+	10	1005_1006	c.875_876TC>AA	c.(874-876)CTC>CAA	p.L292Q	RYR1_uc002oiu.2_Missense_Mutation_p.L292Q	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	292	MIR 4.|Cytoplasmic.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TACCTAGCGCTCACCGAGGACC	0.649		NaN											0	0	0	0.004672	0	20	271				
PAK4	10298	broad.mit.edu	37	19	39660239	39660239	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:39660239A>C	uc002okj.1	+	4	507	c.46A>C	c.(46-48)AAC>CAC	p.N16H	PAK4_uc002okl.1_Missense_Mutation_p.N16H|PAK4_uc002okn.1_Missense_Mutation_p.N16H|PAK4_uc002okm.1_Missense_Mutation_p.N16H|PAK4_uc002oko.1_Missense_Mutation_p.N16H|PAK4_uc002okp.1_Missense_Mutation_p.N16H	NM_001014831	NP_001014831	O96013	PAK4_HUMAN	p21-activated kinase 4 isoform 1	16	CRIB.				cellular component movement|signal transduction	Golgi apparatus	ATP binding|protein binding|protein serine/threonine kinase activity			lung(3)|ovary(1)	4	all_cancers(60;1.03e-07)|all_epithelial(25;9.66e-08)|all_lung(34;1.58e-07)|Lung NSC(34;1.88e-07)|Ovarian(47;0.0454)		Epithelial(26;4.82e-25)|all cancers(26;2.94e-22)|Lung(45;0.000797)|LUSC - Lung squamous cell carcinoma(53;0.00113)			CGCGCCGTCCAACTTCGAGCA	0.657		NaN											0	0	0	0.01441	0	52	91				
SPTBN4	57731	broad.mit.edu	37	19	41035036	41035036	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:41035036G>A	uc002ony.2	+	18	4032	c.3946G>A	c.(3946-3948)GAG>AAG	p.E1316K	SPTBN4_uc002onx.2_Missense_Mutation_p.E1316K|SPTBN4_uc002onz.2_Missense_Mutation_p.E1316K|SPTBN4_uc010egx.2_Missense_Mutation_p.E59K|SPTBN4_uc010egy.1_5'Flank|SPTBN4_uc002ooa.2_5'Flank|SPTBN4_uc010egz.1_5'Flank	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	1316	Spectrin 11.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AGACTGCCACGAGGTAGGAAC	0.597		NaN									OREG0025472	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008871	0	19	72				
B3GNT8	374907	broad.mit.edu	37	19	41932181	41932181	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:41932181C>G	uc002oqs.2	-	3	957	c.503G>C	c.(502-504)AGA>ACA	p.R168T	CYP2F1_uc010xvw.1_Intron|B3GNT8_uc002oqt.1_Intron	NM_198540	NP_940942	Q7Z7M8	B3GN8_HUMAN	UDP-GlcNAc:betaGal	168	Lumenal (Potential).				poly-N-acetyllactosamine biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	galactosyltransferase activity|protein N-acetylglucosaminyltransferase activity				0						CCACGTCTCTCTCACGGCCTG	0.627		NaN											0	0	0	0.01441	0	51	96				
MARK4	57787	broad.mit.edu	37	19	45767973	45767973	+	Silent	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:45767973G>A	uc002pbb.1	+	5	392	c.387G>A	c.(385-387)AAG>AAA	p.K129K	MARK4_uc002paz.1_Intron|MARK4_uc002pba.1_Silent_p.K129K|MARK4_uc002pbc.1_5'UTR			Q96L34	MARK4_HUMAN	RecName: Full=MAP/microtubule affinity-regulating kinase 4;          EC=2.7.11.1; AltName: Full=MAP/microtubule affinity-regulating kinase-like 1;	129	Protein kinase.				microtubule bundle formation|nervous system development|positive regulation of programmed cell death	centrosome|neuron projection	ATP binding|gamma-tubulin binding|microtubule binding|protein serine/threonine kinase activity|tau-protein kinase activity|ubiquitin binding			central_nervous_system(2)|large_intestine(1)	3		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		AGACTGAGAAGACGCTGTACC	0.577		NaN											0	0	0	0.01441	0	87	51				
PPP1R13L	10848	broad.mit.edu	37	19	45895489	45895489	+	Silent	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:45895489G>A	uc002pbn.2	-	8	1541	c.1464C>T	c.(1462-1464)CTC>CTT	p.L488L	PPP1R13L_uc002pbm.2_Silent_p.L67L|PPP1R13L_uc002pbo.2_Silent_p.L488L	NM_006663	NP_006654	Q8WUF5	IASPP_HUMAN	protein phosphatase 1, regulatory subunit 13	488	Pro-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	transcription corepressor activity|transcription factor binding			skin(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0182)		TCGTGGGGCTGAGAGGCCTTG	0.672		NaN											0	0	0	0.007291	0	31	27				
LMTK3	114783	broad.mit.edu	37	19	49013790	49013790	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:49013790A>G	uc002pjk.2	-	3	223	c.223T>C	c.(223-225)TGC>CGC	p.C75R		NM_001080434	NP_001073903			lemur tyrosine kinase 3											lung(5)|central_nervous_system(1)	6		all_lung(116;0.000147)|Lung NSC(112;0.000251)|all_epithelial(76;0.000326)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000114)|all cancers(93;0.000141)|Epithelial(262;0.00854)|GBM - Glioblastoma multiforme(486;0.0231)		AGGCCGGAGCAGGAAATGAGG	0.622		NaN											0	0	0	0.001984	0	6	3				
ALDH16A1	126133	broad.mit.edu	37	19	49971709	49971709	+	Silent	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:49971709C>T	uc002pnt.2	+	15	2126	c.2010C>T	c.(2008-2010)GAC>GAT	p.D670D	ALDH16A1_uc010yar.1_Silent_p.D619D|ALDH16A1_uc010yas.1_Silent_p.D505D|ALDH16A1_uc010yat.1_Silent_p.D507D	NM_153329	NP_699160	Q8IZ83	A16A1_HUMAN	aldehyde dehydrogenase 16 family, member A1	670							oxidoreductase activity|protein binding			skin(1)	1		all_lung(116;5.39e-06)|Lung NSC(112;1.97e-05)|all_neural(266;0.0966)|Ovarian(192;0.15)		OV - Ovarian serous cystadenocarcinoma(262;0.00156)|GBM - Glioblastoma multiforme(486;0.0251)		TGTGTCCGGACGAGTGGCCCC	0.701		NaN											0	0	0	0.01441	0	114	79				
CACNG8	59283	broad.mit.edu	37	19	54483176	54483176	+	Silent	SNP	C	C	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:54483176C>G	uc002qcs.1	+	3	526	c.420C>G	c.(418-420)CTC>CTG	p.L140L	MIR935_hsa-mir-935|MI0005757_5'Flank	NM_031895	NP_114101	Q8WXS5	CCG8_HUMAN	voltage-dependent calcium channel gamma-8	141	Helical; (Potential).				regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic density|postsynaptic membrane|voltage-gated calcium channel complex	voltage-gated calcium channel activity				0	all_cancers(19;0.0385)|all_epithelial(19;0.0207)|all_lung(19;0.145)|Lung NSC(19;0.168)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.162)		TGCTGCTGCTCGGGGGTGTGT	0.637		NaN											0	0	0	0.007413	0	17	7				
BRSK1	84446	broad.mit.edu	37	19	55814746	55814746	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:55814746G>A	uc002qkg.2	+	11	1373	c.1096G>A	c.(1096-1098)GAC>AAC	p.D366N	BRSK1_uc002qkf.2_Missense_Mutation_p.D382N|BRSK1_uc002qkh.2_Missense_Mutation_p.D61N	NM_032430	NP_115806	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	366					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|stomach(1)|lung(1)|breast(1)|skin(1)	6		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		CAGCTGTGAGGACCAGGACCT	0.473		NaN											0	0	0	0.00278	0	23	94				
PEG3	5178	broad.mit.edu	37	19	57335915	57335915	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr19:57335915C>T	uc002qnu.2	-	1	460	c.109G>A	c.(109-111)GAA>AAA	p.E37K	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.E37K|PEG3_uc002qnv.2_Missense_Mutation_p.E37K|PEG3_uc002qnw.2_Intron|PEG3_uc002qnx.2_Intron|PEG3_uc010etr.2_Missense_Mutation_p.E37K	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	37					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		GTTGGACCTTCTCCTATGATG	0.473		NaN											0	0	0	0.01441	0	72	41				
RHOB	388	broad.mit.edu	37	2	20647449	20647449	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:20647449C>A	uc002rdv.2	+	1	615	c.223C>A	c.(223-225)CCG>ACG	p.P75T		NM_004040	NP_004031	P62745	RHOB_HUMAN	ras homolog gene family, member B precursor	75					angiogenesis|axon guidance|cell adhesion|endosome to lysosome transport|negative regulation of cell cycle|platelet activation|positive regulation of angiogenesis|protein transport|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|transformed cell apoptosis	cytosol|late endosome membrane|nucleus|plasma membrane	GTP binding|GTPase activity|protein binding			ovary(1)|lung(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)	all_epithelial(98;4.19e-09)|Lung NSC(108;0.00452)|Ovarian(717;0.0164)		OV - Ovarian serous cystadenocarcinoma(76;1.14e-22)|Epithelial(75;7.84e-19)		GCTCTCCTACCCGGACACCGA	0.647		NaN											1	0	1.37522e-17	0.007413	1.5426e-17	20	113		Valid		
COMMD1	150684	broad.mit.edu	37	2	62227996	62227996	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:62227996G>T	uc002sbp.2	+	2	352	c.341G>T	c.(340-342)CGC>CTC	p.R114L	COMMD1_uc002sbq.1_RNA	NM_152516	NP_689729	Q8N668	COMD1_HUMAN	MURR1	114					copper ion homeostasis|negative regulation of NF-kappaB transcription factor activity|positive regulation of protein ubiquitination|regulation of proteasomal ubiquitin-dependent protein catabolic process	cell junction|Cul2-RING ubiquitin ligase complex|cytoplasm|nucleolus	copper ion binding|protein homodimerization activity			ovary(1)	1	Lung NSC(7;0.035)|all_lung(7;0.0691)		LUSC - Lung squamous cell carcinoma(7;4.73e-07)|Epithelial(17;0.0216)|all cancers(80;0.0934)			AACCAGAGCCGCTGGAATAGC	0.502		NaN											1	0	5.8336e-16	0.003271	6.45863e-16	36	36				
AUP1	550	broad.mit.edu	37	2	74754952	74754952	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:74754952T>C	uc010yrx.1	-	7	1049	c.923A>G	c.(922-924)GAA>GGA	p.E308G	DQX1_uc010yrw.1_5'Flank|AUP1_uc002sme.2_5'UTR|AUP1_uc002smf.2_Missense_Mutation_p.E251G|AUP1_uc002smg.2_RNA|AUP1_uc002smh.2_Missense_Mutation_p.E160G|HTRA2_uc002smi.1_5'Flank|HTRA2_uc002smj.1_5'Flank|HTRA2_uc002smk.1_5'Flank|HTRA2_uc002sml.1_5'Flank|HTRA2_uc002smm.1_5'Flank|HTRA2_uc002smn.1_5'Flank|HTRA2_uc010ffl.2_5'Flank			Q9Y679	AUP1_HUMAN	SubName: Full=cDNA FLJ57204, highly similar to Homo sapiens ancient ubiquitous protein 1 (AUP1), transcript variant 2, mRNA;	317	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane|nucleus	protein binding				0						CTGGCCCAATTCCTTGGCCAC	0.567		NaN											0	0	0	0.007291	0	30	149				
LOXL3	84695	broad.mit.edu	37	2	74776495	74776495	+	Splice_Site	SNP	C	C	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:74776495C>A	uc002smp.1	-	4	764	c.692_splice	c.e4+1	p.R231_splice	LOXL3_uc002smo.1_Intron|LOXL3_uc010ffm.1_Splice_Site_p.R231_splice|LOXL3_uc002smq.1_Intron|LOXL3_uc010ffn.1_Intron|DOK1_uc002smr.2_Intron	NM_032603	NP_115992	P58215	LOXL3_HUMAN	lysyl oxidase-like 3 precursor							extracellular space|membrane	copper ion binding|protein-lysine 6-oxidase activity|scavenger receptor activity				0						cggccccTCACCTGTAGAAGG	0.567		NaN											1	0	0.004672	0.004672	0.00472745	3	9				
HK2	3099	broad.mit.edu	37	2	75108948	75108948	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:75108948G>T	uc002snd.2	+	11	3607	c.1681G>T	c.(1681-1683)GCC>TCC	p.A561S		NM_000189	NP_000180	P52789	HXK2_HUMAN	hexokinase 2	561	Catalytic.				apoptotic mitochondrial changes|glucose transport|glycolysis|transmembrane transport	cytosol|mitochondrial outer membrane	ATP binding|glucokinase activity			ovary(1)|lung(1)	2						CAAGATCTACGCCATCCCGCA	0.622		NaN											1	0	0.000673444	0.008291	0.00069379	11	11				
DUSP2	1844	broad.mit.edu	37	2	96810513	96810513	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:96810513G>A	uc002svk.3	-	2	583	c.497C>T	c.(496-498)CCT>CTT	p.P166L		NM_004418	NP_004409	Q05923	DUS2_HUMAN	dual specificity phosphatase 2	166					endoderm formation|inactivation of MAPK activity|regulation of apoptosis	nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/threonine phosphatase activity			breast(1)	1		Ovarian(717;0.0228)				GTCGTAGACAGGAGCCCTGGA	0.672		NaN											0	0	0	0.00308	0	6	3				
ZAP70	7535	broad.mit.edu	37	2	98341692	98341692	+	Silent	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:98341692G>A	uc002syd.1	+	4	747	c.540G>A	c.(538-540)GGG>GGA	p.G180G	ZAP70_uc010yvf.1_Silent_p.G180G|ZAP70_uc002sye.1_Silent_p.G70G	NM_001079	NP_001070	P43403	ZAP70_HUMAN	zeta-chain associated protein kinase 70kDa	180	SH2 2.				immune response|intracellular protein kinase cascade|positive thymic T cell selection|T cell receptor signaling pathway	cytosol|T cell receptor complex	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(4)|upper_aerodigestive_tract(1)|ovary(1)	6						TTTACTCTGGGGCGCAGACCG	0.647		NaN											0	0	0	0.001168	0	6	43				
GCC2	9648	broad.mit.edu	37	2	109092306	109092306	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:109092306G>C	uc002tec.2	+	9	3214	c.3060G>C	c.(3058-3060)AAG>AAC	p.K1020N	GCC2_uc002ted.2_Missense_Mutation_p.K919N	NM_181453	NP_852118	Q8IWJ2	GCC2_HUMAN	GRIP and coiled-coil domain-containing 2	1020	Potential.				Golgi ribbon formation|late endosome to Golgi transport|microtubule anchoring|microtubule organizing center organization|protein localization in Golgi apparatus|protein targeting to lysosome|recycling endosome to Golgi transport|regulation of protein exit from endoplasmic reticulum	membrane|trans-Golgi network	identical protein binding			ovary(1)	1						AAAGCTATAAGGTAAAAAATA	0.318		NaN											0	0	0	0.009535	0	32	33				
TTN	7273	broad.mit.edu	37	2	179579734	179579734	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:179579734C>T	uc010zfg.1	-	87	22671	c.22447G>A	c.(22447-22449)GTT>ATT	p.V7483I	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.V4144I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8410							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATGGAACCAACGCAAGTGTCG	0.478		NaN											0	0	0	0.01441	0	97	77				
CDK15	65061	broad.mit.edu	37	2	202687611	202687611	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:202687611C>G	uc002uyt.2	+	5	577	c.528C>G	c.(526-528)TTC>TTG	p.F176L	CDK15_uc010ftm.2_Missense_Mutation_p.F41L|CDK15_uc002uys.2_Missense_Mutation_p.F125L|CDK15_uc010ftn.1_Missense_Mutation_p.F125L|CDK15_uc010fto.1_Missense_Mutation_p.F176L	NM_139158	NP_631897	Q96Q40	CDK15_HUMAN	PFTAIRE protein kinase 2	176	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|metal ion binding|protein binding			breast(2)|ovary(1)|lung(1)|kidney(1)	5					Adenosine triphosphate(DB00171)	CACTGACATTCGTTTTTGAAT	0.343		NaN											0	0	0	0.00874	0	39	70				
ANKZF1	55139	broad.mit.edu	37	2	220098444	220098444	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:220098444G>C	uc002vkg.2	+	8	1001	c.827G>C	c.(826-828)CGT>CCT	p.R276P	ANKZF1_uc010zkv.1_Missense_Mutation_p.R220P|ANKZF1_uc010zkw.1_Missense_Mutation_p.R66P|ANKZF1_uc002vkh.2_Missense_Mutation_p.R66P|ANKZF1_uc002vki.2_Missense_Mutation_p.R276P|ANKZF1_uc002vkj.1_Missense_Mutation_p.R264P	NM_018089	NP_060559	Q9H8Y5	ANKZ1_HUMAN	ankyrin repeat and zinc finger domain containing	276						intracellular	zinc ion binding			ovary(2)	2		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TAGGATGTTCGTGACCTGCTG	0.522		NaN											0	0	0	0.01441	0	44	58				
GMPPA	29926	broad.mit.edu	37	2	220367155	220367155	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:220367155A>C	uc002vlr.2	+	6	549	c.481A>C	c.(481-483)ACA>CCA	p.T161P	GMPPA_uc002vls.2_Missense_Mutation_p.T161P|GMPPA_uc002vlt.2_Missense_Mutation_p.T161P|GMPPA_uc002vlu.2_Missense_Mutation_p.T161P|GMPPA_uc002vlv.2_Missense_Mutation_p.T161P|GMPPA_uc002vlw.2_RNA|GMPPA_uc002vlx.2_Missense_Mutation_p.T161P	NM_013335	NP_037467	Q96IJ6	GMPPA_HUMAN	GDP-mannose pyrophosphorylase A	161					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine		GTP binding|mannose-1-phosphate guanylyltransferase activity				0		Renal(207;0.0183)		Epithelial(149;3.82e-10)|all cancers(144;6.25e-08)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00807)|READ - Rectum adenocarcinoma(5;0.148)		GAATCCACAGACACACGAGGT	0.582		NaN											0	0	0	0.010729	0	11	12				
DIS3L2	129563	broad.mit.edu	37	2	233075041	233075041	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:233075041A>G	uc010fxz.2	+	10	1406	c.1130A>G	c.(1129-1131)GAC>GGC	p.D377G	DIS3L2_uc002vsm.3_RNA|DIS3L2_uc002vso.2_RNA	NM_152383	NP_689596	Q8IYB7	DI3L2_HUMAN	DIS3 mitotic control homolog (S.	377							exonuclease activity|ribonuclease activity|RNA binding			ovary(1)|breast(1)|central_nervous_system(1)	3		all_hematologic(139;0.00809)|Renal(207;0.0113)|Acute lymphoblastic leukemia(138;0.0195)|all_lung(227;0.0465)|Lung NSC(271;0.136)		Epithelial(121;1.6e-13)|BRCA - Breast invasive adenocarcinoma(100;0.00104)|LUSC - Lung squamous cell carcinoma(224;0.0109)|Lung(119;0.0149)		CCTAGAAAAGACTGTATCTTC	0.428		NaN											0	0	0	0.00874	0	41	39				
CHRNG	1146	broad.mit.edu	37	2	233409180	233409180	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:233409180G>T	uc002vsx.1	+	10	1160	c.1139G>T	c.(1138-1140)GGA>GTA	p.G380V	CHRNG_uc010fye.1_Missense_Mutation_p.G328V	NM_005199	NP_005190	P07510	ACHG_HUMAN	cholinergic receptor, nicotinic, gamma	380	Cytoplasmic (Potential).				muscle contraction	cell junction|postsynaptic membrane	acetylcholine receptor activity				0		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;6.39e-16)|BRCA - Breast invasive adenocarcinoma(100;0.00079)|LUSC - Lung squamous cell carcinoma(224;0.00757)|Lung(119;0.0086)		GGCTCCTCGGGATGGTCGATC	0.667		NaN											1	0	2.17126e-26	0.01441	2.48456e-26	50	64				
USP40	55230	broad.mit.edu	37	2	234465604	234465604	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:234465604G>C	uc010zmu.1	-	5	561	c.443C>G	c.(442-444)TCT>TGT	p.S148C	USP40_uc010zmr.1_Missense_Mutation_p.S160C			Q9NVE5	UBP40_HUMAN	SubName: Full=cDNA FLJ56772, highly similar to Ubiquitin carboxyl-terminal hydrolase 40 (EC 3.1.2.15);	148					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(1)|lung(1)|breast(1)	3		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0539)		Epithelial(121;1.71e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000407)|Lung(119;0.00277)|LUSC - Lung squamous cell carcinoma(224;0.00646)		CCCAACTAAAGAAGTTTCCAA	0.428		NaN											0	0	0	0.006999	0	41	34				
KIF1A	547	broad.mit.edu	37	2	241661251	241661251	+	Silent	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:241661251G>A	uc002vzy.2	-	42	4559	c.4413C>T	c.(4411-4413)CAC>CAT	p.H1471H	KIF1A_uc010fzk.2_Silent_p.H1572H|KIF1A_uc002vzw.2_Silent_p.H132H|KIF1A_uc002vzx.2_Silent_p.H198H	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	1471					anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		TGACGCAGACGTGGCTGTGTG	0.652		NaN											0	0	0	0.001984	0	6	10				
ADRA1D	146	broad.mit.edu	37	20	4228599	4228599	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr20:4228599G>A	uc002wkr.2	-	1	1061	c.1006C>T	c.(1006-1008)CGC>TGC	p.R336C		NM_000678	NP_000669	P25100	ADA1D_HUMAN	alpha-1D-adrenergic receptor	336	Cytoplasmic (By similarity).				cell proliferation|cell-cell signaling|DNA metabolic process|G-protein signaling, coupled to cAMP nucleotide second messenger|multicellular organismal development|positive regulation of cell proliferation	integral to plasma membrane	alpha1-adrenergic receptor activity				0					Alfuzosin(DB00346)|Bethanidine(DB00217)|Dapiprazole(DB00298)|Debrisoquin(DB04840)|Doxazosin(DB00590)|Guanadrel Sulfate(DB00226)|Guanethidine(DB01170)|Methotrimeprazine(DB01403)|Norepinephrine(DB00368)|Promazine(DB00420)|Propericiazine(DB01608)|Propiomazine(DB00777)|Sertindole(DB06144)|Tamsulosin(DB00706)|Terazosin(DB01162)	TTGAGCAGGCGCACGGAGAGC	0.667		NaN											0	0	0	0.000602	0	5	14				
SLC23A2	9962	broad.mit.edu	37	20	4854733	4854733	+	Silent	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr20:4854733G>A	uc002wlg.1	-	11	1326	c.951C>T	c.(949-951)ATC>ATT	p.I317I	SLC23A2_uc010zqr.1_Silent_p.I202I|SLC23A2_uc002wlh.1_Silent_p.I317I|SLC23A2_uc002wli.2_Silent_p.I316I	NM_005116	NP_005107	Q9UGH3	S23A2_HUMAN	solute carrier family 23 (nucleobase	317	Helical; (Potential).				L-ascorbic acid metabolic process|molecular hydrogen transport|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transepithelial L-ascorbic acid transport	apical plasma membrane|integral to plasma membrane|membrane fraction	nucleobase transmembrane transporter activity|sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2						GGATGGCCAGGATGATCTGGA	0.552		NaN											0	0	0	0.007291	0	29	102				
C20orf94	128710	broad.mit.edu	37	20	10541378	10541378	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr20:10541378G>C	uc010zre.1	+	4	328	c.148G>C	c.(148-150)GAT>CAT	p.D50H		NM_001009608	NP_001009608	Q5VYV7	CT094_HUMAN	hypothetical protein LOC128710	50							protein binding				0						AGAAACCATTGATTCAAGAGT	0.323		NaN											0	0	0	0.013537	0	12	44				
GGT7	2686	broad.mit.edu	37	20	33460480	33460480	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr20:33460480C>T	uc002xay.2	-	1	182	c.139G>A	c.(139-141)GAG>AAG	p.E47K	GGT7_uc002xaz.1_Missense_Mutation_p.E47K|GGT7_uc002xba.1_Missense_Mutation_p.E47K|ACSS2_uc002xbc.2_5'Flank	NM_178026	NP_821158	Q9UJ14	GGT7_HUMAN	gamma-glutamyltransferase 7	47	Cytoplasmic (Potential).				glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity			ovary(1)	1						AAGGCGTCCTCGTCCTTGCGG	0.697		NaN											0	0	0	0.004482	0	6	20				
PREX1	57580	broad.mit.edu	37	20	47248883	47248883	+	Silent	SNP	C	C	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr20:47248883C>G	uc002xtw.1	-	35	4481	c.4458G>C	c.(4456-4458)GCG>GCC	p.A1486A	PREX1_uc002xtv.1_Silent_p.A783A	NM_020820	NP_065871	Q8TCU6	PREX1_HUMAN	phosphatidylinositol-3,4,	1486					actin filament polymerization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|neutrophil activation|small GTPase mediated signal transduction|superoxide metabolic process	cytosol|plasma membrane	enzyme binding|phospholipid binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|ovary(2)|pancreas(1)	6			BRCA - Breast invasive adenocarcinoma(12;0.0135)|Colorectal(8;0.198)			GCAAATCCTCCGCGGCCTGGC	0.647		NaN											0	0	0	0.01441	0	49	131				
SFRS15	57466	broad.mit.edu	37	21	33044500	33044500	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr21:33044500T>C	uc002ypd.2	-	20	3082	c.2656A>G	c.(2656-2658)ATG>GTG	p.M886V	SFRS15_uc002ype.2_Missense_Mutation_p.M864V|SFRS15_uc010glu.2_Missense_Mutation_p.M871V	NM_020706	NP_065757	O95104	SFR15_HUMAN	splicing factor, arginine/serine-rich 15 isoform	886						nucleus	nucleotide binding|RNA binding				0						CCTCTGTGCATCATGTGCGGT	0.647		NaN											0	0	0	0.010729	0	11	60				
PCBP3	54039	broad.mit.edu	37	21	47330884	47330884	+	Silent	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr21:47330884C>T	uc002zhq.1	+	7	665	c.540C>T	c.(538-540)ATC>ATT	p.I180I	PCBP3_uc010gqb.2_Silent_p.I180I|PCBP3_uc002zhp.1_Silent_p.I180I|PCBP3_uc010gqc.1_Silent_p.I180I|PCBP3_uc002zhs.1_Silent_p.I180I|PCBP3_uc002zhr.1_Silent_p.I180I|PCBP3_uc002zht.1_Silent_p.I148I	NM_020528	NP_065389	P57721	PCBP3_HUMAN	poly(rC) binding protein 3 isoform 1	180	KH 2.				mRNA metabolic process	cytosol|mitochondrion|nucleus|ribonucleoprotein complex	DNA binding|RNA binding			skin(1)	1	all_hematologic(128;0.24)			Colorectal(79;0.0411)|READ - Rectum adenocarcinoma(84;0.0649)		CGGTGACCATCTCGGGGACCC	0.642		NaN											0	0	0	0.010504	0	19	23				
C21orf58	54058	broad.mit.edu	37	21	47722421	47722421	+	Missense_Mutation	SNP	T	T	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr21:47722421T>G	uc002zjf.2	-	8	1925	c.791A>C	c.(790-792)AAG>ACG	p.K264T	C21orf58_uc002ziz.2_Missense_Mutation_p.K181T|C21orf58_uc002zja.2_Missense_Mutation_p.K158T|C21orf58_uc011afw.1_Missense_Mutation_p.K181T|C21orf58_uc002zjc.2_Missense_Mutation_p.K158T|C21orf58_uc011afx.1_Missense_Mutation_p.K158T|C21orf58_uc010gqj.1_RNA	NM_058180	NP_478060	P58505	CU058_HUMAN	hypothetical protein LOC54058	264										pancreas(1)	1	Breast(49;0.112)			Colorectal(79;0.239)		GGGCAGGGCCTTGAGCATCCA	0.582		NaN											0	0	0	0.006214	0	9	11				
COMT	1312	broad.mit.edu	37	22	19951251	19951251	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr22:19951251G>C	uc002zqu.2	+	4	701	c.452G>C	c.(451-453)CGG>CCG	p.R151P	COMT_uc002zqt.2_Missense_Mutation_p.R151P|COMT_uc002zqv.2_Missense_Mutation_p.R151P|COMT_uc002zqw.2_Missense_Mutation_p.R151P|COMT_uc011ahd.1_Missense_Mutation_p.R151P|COMT_uc002zqx.2_Missense_Mutation_p.R151P	NM_000754	NP_000745	P21964	COMT_HUMAN	catechol-O-methyltransferase isoform MB-COMT	151					neurotransmitter biosynthetic process|neurotransmitter catabolic process|xenobiotic metabolic process	cytosol|integral to membrane|intracellular membrane-bounded organelle|microsome|plasma membrane|soluble fraction	catechol O-methyltransferase activity|magnesium ion binding|protein binding			ovary(1)	1	Colorectal(54;0.0993)				Carbidopa(DB00190)|Conjugated Estrogens(DB00286)|Diethylstilbestrol(DB00255)|Dobutamine(DB00841)|Dopamine(DB00988)|Entacapone(DB00494)|Folic Acid(DB00158)|L-Valine(DB00161)|Levodopa(DB01235)|Methyldopa(DB00968)|Modafinil(DB00745)|Morphine(DB00295)|S-Adenosylmethionine(DB00118)|Tolcapone(DB00323)	ATCACCCAGCGGATGGTGGAT	0.627		NaN											0	0	0	0.00278	0	22	19				
THOC5	8563	broad.mit.edu	37	22	29925227	29925227	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr22:29925227A>T	uc003afr.2	-	10	1184	c.849T>A	c.(847-849)GAT>GAA	p.D283E	THOC5_uc003afq.2_5'Flank|THOC5_uc003afs.2_Missense_Mutation_p.D283E|THOC5_uc003aft.2_Missense_Mutation_p.D283E|THOC5_uc003afu.2_Missense_Mutation_p.D283E|THOC5_uc010gvo.2_Missense_Mutation_p.N27K|THOC5_uc003afv.1_Missense_Mutation_p.D294E	NM_001002878	NP_001002878	Q13769	THOC5_HUMAN	THO complex 5	283					intronless viral mRNA export from host nucleus|monocyte differentiation|mRNA processing|primitive hemopoiesis|RNA splicing	cytoplasm|intermediate filament cytoskeleton|THO complex part of transcription export complex	protein binding|RNA binding			breast(3)	3						ATAACGTCTTATCTGGGGGGC	0.532		NaN											0	0	0	0.01441	0	55	90				
GALNTL2	117248	broad.mit.edu	37	3	16217067	16217067	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr3:16217067G>A	uc003car.3	+	1	884	c.409G>A	c.(409-411)GCT>ACT	p.A137T	GALNTL2_uc003caq.3_Intron	NM_054110	NP_473451	Q8N3T1	GLTL2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	137	Lumenal (Potential).					Golgi membrane|integral to membrane|transport vesicle	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(1)	1						GGACTGGGGGGCTGATGAGGA	0.637		NaN											0	0	0	0.00245	0	14	55				
WDR6	11180	broad.mit.edu	37	3	49051011	49051011	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr3:49051011T>A	uc003cvj.2	+	2	2272	c.2134T>A	c.(2134-2136)TAC>AAC	p.Y712N	WDR6_uc011bbx.1_3'UTR|WDR6_uc011bby.1_Missense_Mutation_p.Y160N|WDR6_uc010hkn.2_Missense_Mutation_p.Y656N|WDR6_uc011bbz.1_Missense_Mutation_p.Y631N	NM_018031	NP_060501	Q9NNW5	WDR6_HUMAN	WD repeat domain 6 protein	682	WD 11.				cell cycle arrest|negative regulation of cell proliferation	cytoplasm				central_nervous_system(1)	1				Kidney(197;9.12e-07)|KIRC - Kidney renal clear cell carcinoma(197;1.32e-05)|BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|OV - Ovarian serous cystadenocarcinoma(275;0.000155)		TGTCATGCTGTACAGGGCTCT	0.587		NaN									OREG0015565	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.006122	0	18	36				
ZNF654	55279	broad.mit.edu	37	3	88189288	88189288	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr3:88189288C>G	uc003dqv.2	+	1	1027	c.828C>G	c.(826-828)AAC>AAG	p.N276K	CGGBP1_uc003dqu.2_Intron	NM_018293	NP_060763	Q8IZM8	ZN654_HUMAN	zinc finger protein 654	276	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(201;0.0283)		UCEC - Uterine corpus endometrioid carcinoma (27;0.194)|LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00661)		TTAATTGCAACGAGTCGTTTA	0.373		NaN											0	0	0	0.013114	0	46	71				
TRAT1	50852	broad.mit.edu	37	3	108572572	108572572	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr3:108572572G>T	uc003dxi.1	+	6	553	c.409G>T	c.(409-411)GAT>TAT	p.D137Y	TRAT1_uc010hpx.1_Missense_Mutation_p.D100Y	NM_016388	NP_057472	Q6PIZ9	TRAT1_HUMAN	T-cell receptor interacting molecule	137	Cytoplasmic (Potential).				cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(1)	1						CAAGGATGGAGATGAGCAACT	0.453		NaN											1	0	2.41591e-17	0.004656	2.69224e-17	28	99				
TAGLN3	29114	broad.mit.edu	37	3	111718304	111718304	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr3:111718304G>A	uc003dym.2	+	2	413	c.35G>A	c.(34-36)CGA>CAA	p.R12Q	TAGLN3_uc003dyl.2_Missense_Mutation_p.R12Q|TAGLN3_uc003dyn.2_Missense_Mutation_p.R12Q|TAGLN3_uc003dyo.2_Missense_Mutation_p.R12Q	NM_001008272	NP_001008273	Q9UI15	TAGL3_HUMAN	transgelin 3	12					central nervous system development|muscle organ development						0						GGCTTAAGCCGAGAGGTGCAG	0.587		NaN											0	0	0	0.001855	0	13	61				
PARP14	54625	broad.mit.edu	37	3	122399790	122399790	+	Silent	SNP	G	G	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr3:122399790G>T	uc003efq.3	+	1	119	c.60G>T	c.(58-60)CCG>CCT	p.P20P		NM_017554	NP_060024	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	20					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			ovary(2)|breast(2)|lung(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(114;0.0531)		CCGACCCCCCGAAGAACTTGA	0.682		NaN											1	0	1.06961e-07	0.00308	1.13626e-07	6	15				
ZXDC	79364	broad.mit.edu	37	3	126191141	126191141	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr3:126191141C>G	uc003eiv.2	-	2	969	c.915G>C	c.(913-915)GAG>GAC	p.E305D	ZXDC_uc010hsh.2_RNA|ZXDC_uc003eix.2_Missense_Mutation_p.E305D	NM_025112	NP_079388	Q2QGD7	ZXDC_HUMAN	ZXD family zinc finger C isoform 1	305	C2H2-type 5.				positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|LRR domain binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.155)		TAAATGTCTTCTCACAGCCTG	0.478		NaN											0	0	0	0.005524	0	36	75				
PLXNA1	5361	broad.mit.edu	37	3	126707544	126707544	+	Silent	SNP	T	T	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr3:126707544T>G	uc003ejg.2	+	1	43	c.39T>G	c.(37-39)GGT>GGG	p.G13G		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	36	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		CAGGCGGGGGTTCACAGCCCC	0.567		NaN											0	0	0	0.00499	0	11	30				
COL6A6	131873	broad.mit.edu	37	3	130282263	130282263	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr3:130282263C>T	uc010htl.2	+	2	447	c.416C>T	c.(415-417)GCT>GTT	p.A139V		NM_001102608	NP_001096078	A6NMZ7	CO6A6_HUMAN	collagen type VI alpha 6 precursor	139	Nonhelical region.|VWFA 1.				axon guidance|cell adhesion	collagen				ovary(6)|central_nervous_system(1)|pancreas(1)	8						GTGGTCCTGGCTTCATCTGAG	0.493		NaN											0	0	0	0.010818	0	33	38				
GNB4	59345	broad.mit.edu	37	3	179131259	179131259	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr3:179131259G>C	uc003fjv.3	-	8	920	c.640C>G	c.(640-642)CGA>GGA	p.R214G	GNB4_uc003fju.3_Missense_Mutation_p.R125G	NM_021629	NP_067642	Q9HAV0	GBB4_HUMAN	guanine nucleotide-binding protein, beta-4	214	WD 4.				cellular response to glucagon stimulus|energy reserve metabolic process	plasma membrane	signal transducer activity			skin(2)	2	all_cancers(143;2.01e-16)|Ovarian(172;0.0172)|Breast(254;0.191)		OV - Ovarian serous cystadenocarcinoma(80;5.78e-26)|GBM - Glioblastoma multiforme(14;0.0169)|BRCA - Breast invasive adenocarcinoma(182;0.237)			ATTCCATCTCGAATATCCCAT	0.398		NaN											0	0	0	0.00632	0	27	99				
ST6GAL1	6480	broad.mit.edu	37	3	186793484	186793484	+	Silent	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr3:186793484C>T	uc003frb.2	+	8	1546	c.1114C>T	c.(1114-1116)CTG>TTG	p.L372L	ST6GAL1_uc003frc.2_Silent_p.L141L|ST6GAL1_uc003frd.2_Silent_p.L372L	NM_173216	NP_775323	P15907	SIAT1_HUMAN	ST6 beta-galactosamide	372	Lumenal (Potential).				humoral immune response|post-translational protein modification|protein N-linked glycosylation via asparagine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			central_nervous_system(1)	1	all_cancers(143;2.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;8.53e-19)	GBM - Glioblastoma multiforme(93;0.0939)		CTACCACCCGCTGCTCTATGA	0.512		NaN											0	0	0	0.001168	0	6	76				
UCHL1	7345	broad.mit.edu	37	4	41259007	41259007	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr4:41259007C>G	uc003gvo.2	+	1	110	c.14C>G	c.(13-15)CCG>CGG	p.P5R	UCHL1_uc003gvp.2_5'UTR|UCHL1_uc003gvq.2_5'UTR|UCHL1_uc003gvr.2_5'UTR	NM_004181	NP_004172	P09936	UCHL1_HUMAN	ubiquitin carboxyl-terminal esterase L1	5	Interaction with ubiquitin.				cell death|negative regulation of MAP kinase activity|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus|plasma membrane	alpha-2A adrenergic receptor binding|cysteine-type endopeptidase activity|ligase activity|omega peptidase activity|ubiquitin binding|ubiquitin thiolesterase activity			central_nervous_system(1)|skin(1)	2						CAGCTCAAGCCGATGGAGATC	0.652		NaN											0	0	0	0.00333	0	22	45				
TET2	54790	broad.mit.edu	37	4	106158065	106158065	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr4:106158065C>T	uc003hxk.2	+	3	3352	c.2966C>T	c.(2965-2967)CCA>CTA	p.P989L	TET2_uc011cez.1_Missense_Mutation_p.P1010L|TET2_uc003hxj.2_RNA|TET2_uc010ilp.1_Missense_Mutation_p.P989L|TET2_uc003hxi.1_Missense_Mutation_p.P989L	NM_001127208	NP_001120680	Q6N021	TET2_HUMAN	tet oncogene family member 2 isoform a	989					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			haematopoietic_and_lymphoid_tissue(732)|pancreas(1)	733		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		GGATGCAAGCCACATGCCTGT	0.463		NaN	Mis N|F		MDS								0	0	0	0.00632	0	29	25				
NPY2R	4887	broad.mit.edu	37	4	156136030	156136030	+	Silent	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr4:156136030C>T	uc003ioq.2	+	2	1434	c.939C>T	c.(937-939)ATC>ATT	p.I313I	NPY2R_uc003ior.2_Silent_p.I313I	NM_000910	NP_000901	P49146	NPY2R_HUMAN	neuropeptide Y receptor Y2	313	Helical; Name=7; (Potential).				cardiac left ventricle morphogenesis|inhibition of adenylate cyclase activity by G-protein signaling pathway|locomotory behavior|outflow tract morphogenesis	integral to plasma membrane	calcium channel regulator activity			lung(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0854)				TCCACATCATCGCCATGTGCT	0.542		NaN											0	0	0	0.010504	0	22	38				
ETFDH	2110	broad.mit.edu	37	4	159593615	159593615	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr4:159593615G>T	uc003iqb.2	+	1	339	c.7G>T	c.(7-9)GTG>TTG	p.V3L	C4orf46_uc003iqa.2_5'Flank|C4orf46_uc010iqp.1_5'Flank|ETFDH_uc010iqq.2_RNA|ETFDH_uc011cjg.1_Missense_Mutation_p.V3L|ETFDH_uc010iqr.2_5'UTR	NM_004453	NP_004444	Q16134	ETFD_HUMAN	electron-transferring-flavoprotein dehydrogenase	3					fatty acid beta-oxidation using acyl-CoA dehydrogenase|respiratory electron transport chain|response to oxidative stress|transport	integral to mitochondrial inner membrane|mitochondrial matrix	4 iron, 4 sulfur cluster binding|electron carrier activity|electron-transferring-flavoprotein dehydrogenase activity|flavin adenine dinucleotide binding|metal ion binding|oxidoreductase activity, oxidizing metal ions with flavin as acceptor|ubiquinone binding			large_intestine(2)|skin(1)	3	all_hematologic(180;0.24)	Renal(120;0.0458)		COAD - Colon adenocarcinoma(41;0.0172)		GAACATGCTGGTGCCGCTAGC	0.652		NaN									OREG0016379	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	8.04996e-18	0.012319	9.05952e-18	19	42				
SDHA	6389	broad.mit.edu	37	5	240522	240522	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr5:240522G>A	uc003jao.3	+	11	1597	c.1482G>A	c.(1480-1482)ATG>ATA	p.M494I	SDHA_uc011clv.1_Missense_Mutation_p.M494I|SDHA_uc011clw.1_Missense_Mutation_p.M446I|SDHA_uc003jap.3_Missense_Mutation_p.M494I|SDHA_uc003jaq.3_Missense_Mutation_p.M269I|SDHA_uc003jar.3_Missense_Mutation_p.M88I	NM_004168	NP_004159	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A,	494					nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity				0			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	AATCTGTCATGAATCTTGACA	0.398		NaN							Familial_Paragangliomas				0	0	0	0.004007	0	14	48				
PAPD7	11044	broad.mit.edu	37	5	6750553	6750553	+	Silent	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr5:6750553C>T	uc003jdx.1	+	10	1176	c.1047C>T	c.(1045-1047)AGC>AGT	p.S349S	PAPD7_uc011cmn.1_Silent_p.S340S|PAPD7_uc010itl.1_Silent_p.S169S	NM_006999	NP_008930	Q5XG87	PAPD7_HUMAN	DNA polymerase sigma	349	Ser-rich.				cell division|DNA replication|double-strand break repair|mitotic chromosome condensation|response to drug|sister chromatid cohesion	nucleus	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|SMC protein binding			ovary(1)	1						CGCTGTCCAGCCCCCAGCTCC	0.572		NaN											0	0	0	0.007413	0	20	33				
CCT5	22948	broad.mit.edu	37	5	10254792	10254792	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr5:10254792A>T	uc003jeq.2	+	3	344	c.173A>T	c.(172-174)GAT>GTT	p.D58V	CCT5_uc011cmq.1_Intron|CCT5_uc003jer.2_Missense_Mutation_p.D58V|CCT5_uc010its.2_Missense_Mutation_p.D58V|CCT5_uc011cmr.1_Intron|CCT5_uc011cms.1_Missense_Mutation_p.D20V|CCT5_uc011cmt.1_Intron	NM_012073	NP_036205	P48643	TCPE_HUMAN	chaperonin containing TCP1, subunit 5 (epsilon)	58					'de novo' posttranslational protein folding|response to virus	microtubule organizing center|nucleolus	ATP binding|unfolded protein binding			ovary(2)	2						TTAGGGCTTGATAAGATGATG	0.418		NaN											0	0	0	0.012319	0	19	74				
C5orf51	285636	broad.mit.edu	37	5	41917223	41917223	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr5:41917223A>G	uc003jmo.2	+	6	707	c.707A>G	c.(706-708)GAT>GGT	p.D236G		NM_175921	NP_787117	A6NDU8	CE051_HUMAN	hypothetical protein LOC285636	236											0						CATGAAGTGGATACTAGTGTG	0.418		NaN											0	0	0	0.012213	0	33	61				
MAP3K1	4214	broad.mit.edu	37	5	56181840	56181840	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr5:56181840G>A	uc003jqw.3	+	17	4565	c.4064G>A	c.(4063-4065)CGT>CAT	p.R1355H		NM_005921	NP_005912	Q13233	M3K1_HUMAN	mitogen-activated protein kinase kinase kinase	1355	Protein kinase.				cellular response to mechanical stimulus|innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(810;4.65e-05)|Prostate(74;0.0132)|Breast(144;0.0321)|Ovarian(174;0.223)		OV - Ovarian serous cystadenocarcinoma(10;6.08e-40)		CAGTTACTCCGTGGCCTTTCG	0.338		NaN											0	0	0	0.007291	0	25	43				
MEF2C	4208	broad.mit.edu	37	5	88018629	88018629	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr5:88018629G>C	uc003kjj.2	-	11	1887	c.1214C>G	c.(1213-1215)CCT>CGT	p.P405R	MEF2C_uc003kji.2_Missense_Mutation_p.P397R|MEF2C_uc003kjk.2_Missense_Mutation_p.P405R|MEF2C_uc003kjm.2_Missense_Mutation_p.P395R|MEF2C_uc003kjl.2_Missense_Mutation_p.P415R	NM_002397	NP_002388	Q06413	MEF2C_HUMAN	myocyte enhancer factor 2C isoform 1	405					apoptosis|B cell proliferation|innate immune response|learning or memory|muscle cell differentiation|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|neuron development|positive regulation of muscle cell differentiation|positive regulation of survival gene product expression|positive regulation of transcription from RNA polymerase II promoter|regulation of germinal center formation|regulation of megakaryocyte differentiation|regulation of synaptic activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nuclear speck	activating transcription factor binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			lung(3)|breast(2)|ovary(1)|large_intestine(1)	7		all_cancers(142;6.67e-05)|all_epithelial(76;7.77e-07)|Lung NSC(167;0.00566)|all_lung(232;0.00732)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;1.04e-33)|Epithelial(54;1.6e-28)|all cancers(79;2.9e-25)		GTATCTCGAAGGGGTGGTGGT	0.532		NaN								HNSCC(66;0.2)			0	0	0	0.00245	0	14	31				
SNCAIP	9627	broad.mit.edu	37	5	121786478	121786478	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr5:121786478C>T	uc003ksw.1	+	10	2142	c.1936C>T	c.(1936-1938)CAG>TAG	p.Q646*	SNCAIP_uc011cwl.1_Nonsense_Mutation_p.Q204*|SNCAIP_uc003ksx.1_Nonsense_Mutation_p.Q693*|SNCAIP_uc003ksy.1_Nonsense_Mutation_p.Q280*|SNCAIP_uc003ksz.1_Nonsense_Mutation_p.Q280*|SNCAIP_uc010jcu.2_Nonsense_Mutation_p.Q242*|SNCAIP_uc011cwm.1_Nonsense_Mutation_p.Q280*|SNCAIP_uc003kta.1_Nonsense_Mutation_p.Q278*|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Nonsense_Mutation_p.Q340*|SNCAIP_uc010jcx.1_Nonsense_Mutation_p.Q586*|uc003ktb.1_Intron|SNCAIP_uc003ktc.1_Nonsense_Mutation_p.Q162*	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	646					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		CCAGGATGCTCAGGCTTCCTC	0.443		NaN											0	0	0	0.006214	0	10	47				
RAPGEF6	51735	broad.mit.edu	37	5	130799891	130799891	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr5:130799891C>T	uc003kvn.1	-	18	2529	c.2323G>A	c.(2323-2325)GAA>AAA	p.E775K	RAPGEF6_uc003kvp.1_Missense_Mutation_p.E825K|RAPGEF6_uc003kvo.1_Missense_Mutation_p.E780K|RAPGEF6_uc010jdi.1_Missense_Mutation_p.E775K|RAPGEF6_uc010jdj.1_Missense_Mutation_p.E775K|RAPGEF6_uc003kvq.2_Missense_Mutation_p.E492K|RAPGEF6_uc003kvr.2_Missense_Mutation_p.E775K|RAPGEF6_uc011cxe.1_RNA|RAPGEF6_uc010jdk.2_Missense_Mutation_p.E775K	NM_016340	NP_057424	Q8TEU7	RPGF6_HUMAN	PDZ domain-containing guanine nucleotide	775	Ras-associating.				Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		AAAACTACTTCTTTAGCTGTG	0.368		NaN											0	0	0	0.014323	0	23	30				
DDX46	9879	broad.mit.edu	37	5	134143532	134143532	+	Silent	SNP	A	A	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr5:134143532A>C	uc003kzw.2	+	16	2217	c.2049A>C	c.(2047-2049)CTA>CTC	p.L683L	DDX46_uc003kzv.1_RNA	NM_014829	NP_055644	Q7L014	DDX46_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 46	683	Helicase C-terminal.				mRNA processing|RNA splicing	Cajal body|nuclear speck	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			CCCGAGGTCTAGATGTGAAAC	0.438		NaN											0	0	0	0.014323	0	22	37				
FAM13B	51306	broad.mit.edu	37	5	137278576	137278576	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr5:137278576C>G	uc003lbz.2	-	21	3044	c.2510G>C	c.(2509-2511)CGA>CCA	p.R837P	FAM13B_uc003lcb.2_Missense_Mutation_p.R713P|FAM13B_uc003lca.2_Missense_Mutation_p.R809P	NM_016603	NP_057687	Q9NYF5	FA13B_HUMAN	hypothetical protein LOC51306 isoform 1	837					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0						AGAAGCTGCTCGAGAACTTGA	0.323		NaN											0	0	0	0.003271	0	35	43				
PCDHA11	56138	broad.mit.edu	37	5	140249821	140249821	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr5:140249821C>G	uc003lia.2	+	1	1991	c.1133C>G	c.(1132-1134)TCA>TGA	p.S378*	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc011dae.1_Nonsense_Mutation_p.S378*	NM_018902	NP_061725	Q9Y5I1	PCDAB_HUMAN	protocadherin alpha 11 isoform 1 precursor	378	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GACCGTGACTCAGGTGTCAAC	0.587		NaN											0	0	0	0.00499	0	18	72				
ARHGEF37	389337	broad.mit.edu	37	5	149011634	149011634	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr5:149011634C>A	uc003lra.1	+	13	1972	c.1908C>A	c.(1906-1908)GAC>GAA	p.D636E		NM_001001669	NP_001001669	A1IGU5	ARH37_HUMAN	hypothetical protein LOC389337	636	SH3 2.				regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity				0						AGGCCCAGGACAAGAAGGGGA	0.592		NaN											1	0	0.00198382	0.001984	0.00201935	7	50				
SLC36A3	285641	broad.mit.edu	37	5	150660726	150660726	+	Silent	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr5:150660726C>T	uc003ltw.2	-	9	1412	c.993G>A	c.(991-993)AAG>AAA	p.K331K	GM2A_uc011dcs.1_Intron|SLC36A3_uc003ltv.2_Silent_p.K316K|SLC36A3_uc003ltx.2_Silent_p.K372K	NM_181774	NP_861439	Q495N2	S36A3_HUMAN	solute carrier family 36, member 3 isoform 2	331	Extracellular (Potential).					integral to membrane				ovary(2)|skin(1)	3		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGTACATCAGCTTGACTGACT	0.517		NaN											0	0	0	0.006214	0	8	60				
CYFIP2	26999	broad.mit.edu	37	5	156714072	156714072	+	Silent	SNP	G	G	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr5:156714072G>T	uc003lwq.2	+	3	300	c.162G>T	c.(160-162)ACG>ACT	p.T54T	CYFIP2_uc011ddn.1_Silent_p.T54T|CYFIP2_uc011ddo.1_Silent_p.T54T|CYFIP2_uc003lwr.2_Silent_p.T54T|CYFIP2_uc003lws.2_Silent_p.T54T|CYFIP2_uc003lwp.2_5'UTR	NM_001037333	NP_001032410	Q96F07	CYFP2_HUMAN	cytoplasmic FMR1 interacting protein 2	54					apoptosis|cell-cell adhesion	cell junction|perinuclear region of cytoplasm|synapse|synaptosome	protein binding				0	Renal(175;0.00212)	Medulloblastoma(196;0.0306)|all_neural(177;0.0897)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			CATTTGTCACGGGCATTGCAA	0.502		NaN											1	0	2.56e-06	0.009096	2.67779e-06	3	29				
GABRA6	2559	broad.mit.edu	37	5	161128777	161128777	+	Nonstop_Mutation	SNP	T	T	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr5:161128777T>A	uc003lyu.2	+	9	1698	c.1360T>A	c.(1360-1362)TAG>AAG	p.*454K	GABRA6_uc003lyv.2_Nonstop_Mutation_p.*225K	NM_000811	NP_000802	Q16445	GBRA6_HUMAN	gamma-aminobutyric acid A receptor, alpha 6	454					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity			ovary(7)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Renal(175;0.00259)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)		Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CAGTGTTGAATAGCTTGCGGC	0.383		NaN								TCGA Ovarian(5;0.080)			0	0	0	0.003163	0	14	68				
TLX3	30012	broad.mit.edu	37	5	170737358	170737358	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr5:170737358A>T	uc003mbf.2	+	2	708	c.626A>T	c.(625-627)CAG>CTG	p.Q209L	uc003mbe.1_5'Flank	NM_021025	NP_066305	O43711	TLX3_HUMAN	T-cell leukemia homeobox 3	209	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1	Renal(175;0.000159)|Lung NSC(126;0.00576)|all_lung(126;0.00963)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			ACGGACGCGCAGGTCAAGACC	0.642		NaN	T	BCL11B	T-ALL								0	0	0	0.009096	0	3	15				
FOXC1	2296	broad.mit.edu	37	6	1610867	1610867	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr6:1610867G>A	uc003mtp.2	+	1	187	c.187G>A	c.(187-189)GCC>ACC	p.A63T		NM_001453	NP_001444	Q12948	FOXC1_HUMAN	forkhead box C1	63					anti-apoptosis|artery morphogenesis|blood vessel remodeling|brain development|camera-type eye development|cardiac muscle cell proliferation|collagen fibril organization|embryonic heart tube development|germ cell migration|glycosaminoglycan metabolic process|lacrimal gland development|lymphangiogenesis|metanephros development|negative regulation of mitotic cell cycle|neural crest cell fate commitment|Notch signaling pathway|odontogenesis of dentine-containing tooth|ossification|ovarian follicle development|paraxial mesodermal cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|regulation of blood vessel size|regulation of organ growth|regulation of sequence-specific DNA binding transcription factor activity|somitogenesis|ureteric bud development|vascular endothelial growth factor receptor signaling pathway|vasculogenesis|ventricular cardiac muscle tissue morphogenesis	nuclear heterochromatin|transcription factor complex	chromatin DNA binding|DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)	1	Ovarian(93;0.0733)	all_cancers(2;4.45e-07)|all_epithelial(2;4.33e-05)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		Epithelial(2;0.0904)|OV - Ovarian serous cystadenocarcinoma(45;0.095)|all cancers(2;0.168)		CATGGCCCGCGCCTACGGGCC	0.612		NaN											0	0	0	0.009096	0	4	44				
TFAP2A	7020	broad.mit.edu	37	6	10400738	10400738	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr6:10400738C>G	uc003myr.2	-	6	1220	c.968G>C	c.(967-969)CGA>CCA	p.R323P	TFAP2A_uc003myq.2_Missense_Mutation_p.R317P|TFAP2A_uc003mys.2_RNA|TFAP2A_uc011dih.1_Intron|TFAP2A_uc003myt.2_Missense_Mutation_p.R319P	NM_003220	NP_003211	P05549	AP2A_HUMAN	transcription factor AP-2 alpha isoform a	323	H-S-H (helix-span-helix), dimerization.				ectoderm development|positive regulation of bone mineralization|positive regulation of tooth mineralization|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	centrosome|Golgi apparatus|nucleus	chromatin binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription regulatory region DNA binding			ovary(1)	1	Breast(50;0.0427)|Ovarian(93;0.0991)	all_hematologic(90;0.107)				GGAATGTTGTCGGTTGAGAAA	0.488		NaN											0	0	0	0.00333	0	24	62				
MICA	4276	broad.mit.edu	37	6	31378395	31378395	+	Missense_Mutation	SNP	T	T	C	rs17200158		TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr6:31378395T>C	uc003ntk.1	+	2	185	c.146T>C	c.(145-147)GTA>GCA	p.V49A	MICA_uc003rxz.1_5'UTR					RecName: Full=MHC class I polypeptide-related sequence A;          Short=MIC-A; Flags: Precursor;												0		Ovarian(999;0.0253)				CTTGCTGAGGTACATCTGGAT	0.542		NaN											0	0	0	0.000602	0	5	23				
C6orf27	80737	broad.mit.edu	37	6	31733543	31733543	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr6:31733543C>T	uc011dog.1	-	17	2742	c.2504G>A	c.(2503-2505)CGG>CAG	p.R835Q		NM_025258	NP_079534	Q9Y334	G7C_HUMAN	G7c protein precursor	835						extracellular region		p.R835Q(1)		ovary(3)	3						GGTGGTGTGCCGGTCCTGTGG	0.597		NaN											0	0	0	0.004672	0	3	34				
AGPAT1	10554	broad.mit.edu	37	6	32138226	32138226	+	Silent	SNP	G	G	A	rs141411867		TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr6:32138226G>A	uc003oae.2	-	4	804	c.486C>T	c.(484-486)GTC>GTT	p.V162V	PPT2_uc003nzy.1_RNA|AGPAT1_uc011dpj.1_RNA|AGPAT1_uc011dpk.1_Silent_p.V126V|AGPAT1_uc003oaf.2_Silent_p.V162V|AGPAT1_uc003oag.2_Intron|AGPAT1_uc003oah.2_Silent_p.V162V|AGPAT1_uc003oai.1_Silent_p.V162V|AGPAT1_uc011dpl.1_Silent_p.V50V	NM_006411	NP_006402	Q99943	PLCA_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 1	162					energy reserve metabolic process|phosphatidic acid biosynthetic process|positive regulation of cellular metabolic process|positive regulation of cytokine production|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity			central_nervous_system(1)	1						GGGTCTGGGCGACCTCAGACA	0.582		NaN											0	0	0	0.00632	0	28	45				
PACSIN1	29993	broad.mit.edu	37	6	34494142	34494143	+	Nonsense_Mutation	DNP	GG	GG	CT			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr6:34494142_34494143GG>CT	uc003ojo.2	+	2	266_267	c.60_61GG>CT	c.(58-63)TGGGAG>TGCTAG	p.20_21WE>C*	PACSIN1_uc003ojp.2_Nonsense_Mutation_p.20_21WE>C*	NM_020804	NP_065855	Q9BY11	PACN1_HUMAN	protein kinase C and casein kinase substrate in	20_21	FCH.				endocytosis		protein kinase activity				0						ACAGCTTCTGGGAGGTGAGGCT	0.629		NaN											0	0	0	0.004672	0	8	26				
PHF3	23469	broad.mit.edu	37	6	64408130	64408130	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr6:64408130G>C	uc003pep.1	+	6	2724	c.2698G>C	c.(2698-2700)GAG>CAG	p.E900Q	PHF3_uc010kag.1_Missense_Mutation_p.E812Q|PHF3_uc010kah.1_Missense_Mutation_p.E714Q|PHF3_uc003pen.2_Missense_Mutation_p.E812Q|PHF3_uc011dxs.1_Missense_Mutation_p.E169Q	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	900					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			TGAGAAGCAAGAGATGAAAAA	0.333		NaN											0	0	0	0.008361	0	28	58				
DOPEY1	23033	broad.mit.edu	37	6	83848597	83848597	+	Silent	SNP	T	T	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr6:83848597T>A	uc003pjs.1	+	21	5096	c.4836T>A	c.(4834-4836)TCT>TCA	p.S1612S	DOPEY1_uc011dyy.1_Silent_p.S1603S|DOPEY1_uc010kbl.1_Silent_p.S1603S|DOPEY1_uc003pjt.2_RNA	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	1612					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		TTGTTGTATCTGACTTAGAAC	0.413		NaN											0	0	0	0.008361	0	31	47				
C6orf170	221322	broad.mit.edu	37	6	121577357	121577357	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr6:121577357G>C	uc003pyo.1	-	16	1876	c.1808C>G	c.(1807-1809)TCA>TGA	p.S603*	C6orf170_uc003pyq.1_RNA|C6orf170_uc003pyp.1_Nonsense_Mutation_p.S122*	NM_152730	NP_689943	Q96NH3	BROMI_HUMAN	hypothetical protein LOC221322	603					multicellular organismal development	cilium|cytoplasm	Rab GTPase activator activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(226;0.00521)		CAACATTTCTGATCCAGAAAA	0.343		NaN											0	0	0	0.006122	0	18	32				
C7orf28B	221960	broad.mit.edu	37	7	6862992	6862992	+	Splice_Site	SNP	C	C	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr7:6862992C>A	uc003sqx.1	-	5	424	c.391_splice	c.e5-1	p.D131_splice	C7orf28B_uc011jxd.1_Splice_Site|C7orf28B_uc003sqy.1_3'UTR	NM_198097	NP_932765	P86791	CCZ1_HUMAN	hypothetical protein LOC221960							lysosomal membrane					0		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.175)		AAACCTTGTCCTGCAGACGCG	0.478		NaN											1	0	1.06961e-07	0.00308	1.13626e-07	5	37				
BAZ1B	9031	broad.mit.edu	37	7	72883944	72883944	+	Silent	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr7:72883944G>A	uc003tyc.2	-	9	3114	c.2769C>T	c.(2767-2769)TTC>TTT	p.F923F		NM_032408	NP_115784	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B	923					ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	7		Lung NSC(55;0.0659)|all_lung(88;0.152)				CTTTTTCAATGAATAATCCTG	0.418		NaN											0	0	0	0.003163	0	16	56				
SEMA3A	10371	broad.mit.edu	37	7	83758479	83758479	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr7:83758479G>T	uc003uhz.2	-	3	608	c.293C>A	c.(292-294)ACC>AAC	p.T98N		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	98	Sema.				axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						ATCTCTTCTGGTGTAAGATAC	0.299		NaN											1	0	1.75199e-13	0.007291	1.92099e-13	24	78				
SEMA3D	223117	broad.mit.edu	37	7	84628794	84628794	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr7:84628794T>C	uc003uic.2	-	17	2336	c.2296A>G	c.(2296-2298)AGA>GGA	p.R766G	SEMA3D_uc010led.2_Missense_Mutation_p.R766G|SEMA3D_uc003uib.2_Missense_Mutation_p.R405G	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	766	Arg/Lys-rich (basic).				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						TCCAGGTCTCTGTGATGTCTT	0.433		NaN											0	0	0	0.00333	0	25	51				
SAMD9	54809	broad.mit.edu	37	7	92732105	92732105	+	Silent	SNP	A	A	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr7:92732105A>G	uc003umf.2	-	3	3562	c.3306T>C	c.(3304-3306)GCT>GCC	p.A1102A	SAMD9_uc003umg.2_Silent_p.A1102A	NM_017654	NP_060124	Q5K651	SAMD9_HUMAN	sterile alpha motif domain containing 9	1102						cytoplasm				ovary(3)|skin(2)|breast(1)|central_nervous_system(1)	7	all_cancers(62;5.71e-11)|all_epithelial(64;3.25e-10)|Breast(17;0.000675)|Lung NSC(181;0.0969)|all_lung(186;0.125)		STAD - Stomach adenocarcinoma(171;0.000302)			CCCAGTTTAGAGCATTGCCAA	0.373		NaN											0	0	0	0.003271	0	35	111				
MLL5	55904	broad.mit.edu	37	7	104752743	104752743	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr7:104752743A>C	uc003vcm.2	+	27	5074	c.4540A>C	c.(4540-4542)ACT>CCT	p.T1514P	MLL5_uc010ljc.2_Missense_Mutation_p.T1514P|MLL5_uc010ljf.1_Intron|MLL5_uc010ljg.2_Missense_Mutation_p.T248P	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	1514	Pro-rich.				cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						TCAGCAGGCAACTTCTGGAAC	0.473		NaN											0	0	0	0.00632	0	28	57				
FLNC	2318	broad.mit.edu	37	7	128484781	128484781	+	Nonsense_Mutation	SNP	A	A	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr7:128484781A>T	uc003vnz.3	+	21	3471	c.3262A>T	c.(3262-3264)AAG>TAG	p.K1088*	FLNC_uc003voa.3_Nonsense_Mutation_p.K1088*	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	1088	Filamin 9.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						CATCGACACCAAGGGGGCTGG	0.632		NaN											0	0	0	0.007413	0	19	54				
AHCYL2	23382	broad.mit.edu	37	7	129062699	129062699	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr7:129062699G>A	uc011kov.1	+	13	1534	c.1480G>A	c.(1480-1482)GAA>AAA	p.E494K	AHCYL2_uc003vot.2_Missense_Mutation_p.E493K|AHCYL2_uc003vov.2_Missense_Mutation_p.E391K|AHCYL2_uc011kow.1_Missense_Mutation_p.E392K|AHCYL2_uc011kox.1_Missense_Mutation_p.E391K	NM_015328	NP_056143	Q96HN2	SAHH3_HUMAN	S-adenosylhomocysteine hydrolase-like 2 isoform	494					one-carbon metabolic process		adenosylhomocysteinase activity			ovary(2)	2						GCGGACACCAGAACTGACCTG	0.512		NaN											0	0	0	0.00499	0	15	57				
ZC3HC1	51530	broad.mit.edu	37	7	129663417	129663417	+	Silent	SNP	G	G	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr7:129663417G>C	uc003vpi.2	-	8	1194	c.1167C>G	c.(1165-1167)GGC>GGG	p.G389G	ZC3HC1_uc003vph.2_Silent_p.G233G|ZC3HC1_uc010lma.2_Intron	NM_016478	NP_057562	Q86WB0	NIPA_HUMAN	zinc finger, C3HC type 1	389					cell division|mitosis	nucleus	protein kinase binding|zinc ion binding				0	Melanoma(18;0.0435)					GTACCTCCAGGCCAGGGGTGT	0.617		NaN											0	0	0	0.00278	0	24	101				
CSGALNACT1	55790	broad.mit.edu	37	8	19263328	19263328	+	Missense_Mutation	SNP	C	C	G	rs61910741	byFrequency	TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr8:19263328C>G	uc011kyn.1	-	10	2626	c.1562G>C	c.(1561-1563)CGC>CCC	p.R521P	CSGALNACT1_uc011kyo.1_Missense_Mutation_p.R521P|CSGALNACT1_uc003wzg.2_RNA|CSGALNACT1_uc011kyp.1_Missense_Mutation_p.R520P	NM_001130518	NP_001123990	Q8TDX6	CGAT1_HUMAN	chondroitin sulfate	521	Lumenal (Potential).				anatomical structure morphogenesis|cell proliferation|cell recognition|chondroitin sulfate biosynthetic process|chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process|extracellular matrix organization|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|heparin biosynthetic process|nervous system development|UDP-glucuronate metabolic process|UDP-N-acetylgalactosamine metabolic process	Golgi cisterna membrane|integral to Golgi membrane|soluble fraction	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|glucuronosyltransferase activity|glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|peptidoglycan glycosyltransferase activity			central_nervous_system(2)|ovary(1)	3				Colorectal(111;0.182)		TTTCTGTTTGCGAAGGTGAGC	0.488		NaN											0	0	0	0.000602	0	4	77				
WRN	7486	broad.mit.edu	37	8	30998994	30998994	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr8:30998994A>C	uc003xio.3	+	25	3804	c.3016A>C	c.(3016-3018)ACT>CCT	p.T1006P	WRN_uc010lvk.2_Missense_Mutation_p.T473P	NM_000553	NP_000544	Q14191	WRN_HUMAN	Werner syndrome protein	1006					base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			ovary(2)|kidney(2)|large_intestine(1)|lung(1)|skin(1)	7		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		TTTATTTGGCACTGGCAAGGA	0.383		NaN	Mis|N|F|S			osteosarcoma|meningioma|others		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Werner_syndrome				0	0	0	0.010504	0	19	42				
KIAA1429	25962	broad.mit.edu	37	8	95523580	95523580	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr8:95523580C>T	uc003ygo.1	-	13	3236	c.3223G>A	c.(3223-3225)GTT>ATT	p.V1075I	KIAA1429_uc003ygp.2_Missense_Mutation_p.V1075I|KIAA1429_uc010maz.1_RNA	NM_015496	NP_056311	Q69YN4	VIR_HUMAN	hypothetical protein LOC25962 isoform 1	1075					mRNA processing|RNA splicing	nucleus				ovary(1)|skin(1)	2	Breast(36;3.29e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00185)			TTTTCATTAACTCCTTGTGTA	0.363		NaN											0	0	0	0.003163	0	15	25				
PTDSS1	9791	broad.mit.edu	37	8	97342490	97342490	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr8:97342490A>G	uc003yht.1	+	11	1325	c.1223A>G	c.(1222-1224)CAC>CGC	p.H408R	PTDSS1_uc003yhu.1_Missense_Mutation_p.H262R	NM_014754	NP_055569	P48651	PTSS1_HUMAN	phosphatidylserine synthase 1	408					phosphatidylserine biosynthetic process	integral to membrane	transferase activity			ovary(1)	1	Breast(36;6.18e-05)				Phosphatidylserine(DB00144)	TATGCAGAACACTATGGTCAC	0.463		NaN											0	0	0	0.00499	0	17	37				
ZNF706	51123	broad.mit.edu	37	8	102213947	102213947	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr8:102213947A>T	uc003yka.2	-	3	438	c.23T>A	c.(22-24)ATT>AAT	p.I8N	ZNF706_uc003ykb.2_Missense_Mutation_p.I8N	NM_001042510	NP_001035975	Q9Y5V0	ZN706_HUMAN	HSPC038 protein	8						intracellular	zinc ion binding			ovary(2)	2	all_cancers(14;3.3e-07)|all_epithelial(15;3.47e-09)|Lung NSC(17;3.44e-05)|all_lung(17;0.000117)		Epithelial(11;8.57e-11)|all cancers(13;1.43e-08)|OV - Ovarian serous cystadenocarcinoma(57;1.43e-05)			CTGAGACTGAATTTTCTGCTG	0.393		NaN											0	0	0	0.004007	0	11	30				
KHDRBS3	10656	broad.mit.edu	37	8	136619260	136619260	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr8:136619260C>A	uc003yuv.2	+	7	1264	c.870C>A	c.(868-870)AGC>AGA	p.S290R	KHDRBS3_uc003yuw.2_Intron|KHDRBS3_uc010mek.2_RNA	NM_006558	NP_006549	O75525	KHDR3_HUMAN	KH domain containing, RNA binding, signal	290	Tyr-rich.				regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	SH3 domain binding			ovary(2)	2	all_epithelial(106;2.85e-16)|all_neural(2;2.72e-06)|Lung NSC(106;3.95e-06)|all_lung(105;1.11e-05)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.247)			ATGATAACAGCTATAGCACCC	0.403		NaN											1	0	2.28855e-06	0.004289	2.40121e-06	32	89				
GPR172A	79581	broad.mit.edu	37	8	145583976	145583976	+	Missense_Mutation	SNP	G	G	A	rs144912258	byFrequency	TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr8:145583976G>A	uc003zcc.1	+	3	981	c.824G>A	c.(823-825)CGC>CAC	p.R275H	FBXL6_uc003zbz.2_5'Flank|FBXL6_uc003zca.2_5'Flank|FBXL6_uc003zcb.2_5'Flank|FBXL6_uc010mfx.2_5'Flank|GPR172A_uc003zcd.1_Missense_Mutation_p.R275H|GPR172A_uc003zce.1_Missense_Mutation_p.R275H|GPR172A_uc010mfy.1_Missense_Mutation_p.R275H|GPR172A_uc003zcf.1_Missense_Mutation_p.R275H|GPR172A_uc011llc.1_Missense_Mutation_p.R187H	NM_024531	NP_078807	Q9HAB3	RFT3_HUMAN	G protein-coupled receptor 172A precursor	275						integral to plasma membrane	receptor activity|riboflavin transporter activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			CTATCAGCCCGCAGTGCCTGC	0.632		NaN											0	0	0	0.010818	0	29	60				
NFIB	4781	broad.mit.edu	37	9	14146709	14146709	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr9:14146709T>C	uc003zle.2	-	6	1339	c.904A>G	c.(904-906)ACA>GCA	p.T302A	NFIB_uc003zld.2_Missense_Mutation_p.T50A|NFIB_uc003zlf.2_Missense_Mutation_p.T302A|NFIB_uc011lmo.1_Missense_Mutation_p.T302A	NM_005596	NP_005587	O00712	NFIB_HUMAN	nuclear factor I/B	302					anterior commissure morphogenesis|chondrocyte differentiation|Clara cell differentiation|commissural neuron axon guidance|DNA replication|glial cell differentiation|lung ciliated cell differentiation|negative regulation of DNA binding|negative regulation of epithelial cell proliferation involved in lung morphogenesis|negative regulation of mesenchymal cell proliferation involved in lung development|positive regulation of transcription from RNA polymerase II promoter|principal sensory nucleus of trigeminal nerve development|Type I pneumocyte differentiation|Type II pneumocyte differentiation	cerebellar mossy fiber|nucleolus|nucleus	RNA polymerase II transcription corepressor activity|sequence-specific DNA binding RNA polymerase II transcription factor activity				0				GBM - Glioblastoma multiforme(50;4.4e-08)|LUAD - Lung adenocarcinoma(58;0.119)|Lung(218;0.164)		TCGTGCCATGTTCGACTTCCA	0.418		NaN	T	MYB|HGMA2	adenoid cystic carcinoma|lipoma								0	0	0	0.003271	0	32	76				
FREM1	158326	broad.mit.edu	37	9	14819292	14819292	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr9:14819292C>G	uc003zlm.2	-	14	3076	c.2486G>C	c.(2485-2487)GGA>GCA	p.G829A	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	829	CSPG 5.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		TAGAGGAAATCCATTCAGCTC	0.428		NaN											0	0	0	0.006214	0	9	29				
NOL6	65083	broad.mit.edu	37	9	33467712	33467712	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr9:33467712G>A	uc003zsz.2	-	12	1680	c.1579C>T	c.(1579-1581)CAC>TAC	p.H527Y	SUGT1P1_uc010mjq.1_Intron|NOL6_uc003zsy.2_5'Flank|NOL6_uc003zta.2_Missense_Mutation_p.H527Y|NOL6_uc010mjv.2_Missense_Mutation_p.H524Y|NOL6_uc011lob.1_Missense_Mutation_p.H475Y|NOL6_uc003ztb.1_Missense_Mutation_p.H527Y	NM_022917	NP_075068	Q9H6R4	NOL6_HUMAN	nucleolar protein family 6 alpha isoform	527					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			ovary(2)	2			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		GGTCGAGAGTGAGCCAGCAGG	0.622		NaN											0	0	0	0.010729	0	12	41				
C9orf25	203259	broad.mit.edu	37	9	34401056	34401056	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr9:34401056T>C	uc011lok.1	-	6	771	c.464A>G	c.(463-465)GAC>GGC	p.D155G	C9orf25_uc003zuj.2_Missense_Mutation_p.D138G|C9orf25_uc003zuk.2_Missense_Mutation_p.D127G|C9orf25_uc011lol.1_Missense_Mutation_p.D143G|C9orf25_uc003zul.2_Missense_Mutation_p.D126G	NM_147202	NP_671735	Q8IW50	CI025_HUMAN	hypothetical protein LOC203259	155											0	all_epithelial(49;0.244)		LUSC - Lung squamous cell carcinoma(29;0.0107)	GBM - Glioblastoma multiforme(74;0.0858)		GTCCTCGTCGTCGGGGATCTC	0.617		NaN											0	0	0	0.001855	0	13	73				
KIAA1045	23349	broad.mit.edu	37	9	34971556	34971556	+	Silent	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr9:34971556C>T	uc003zvq.2	+	2	439	c.261C>T	c.(259-261)GGC>GGT	p.G87G	KIAA1045_uc003zvr.2_Silent_p.G87G	NM_015297	NP_056112	Q9UPV7	K1045_HUMAN	hypothetical protein LOC23349	87							calcium ion binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(32;0.00575)			ATGGGCGCGGCGTGGAGCCTG	0.617		NaN											0	0	0	0.01441	0	54	107				
POLR1E	64425	broad.mit.edu	37	9	37486692	37486692	+	Silent	SNP	T	T	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr9:37486692T>G	uc003zzz.1	+	1	543	c.255T>G	c.(253-255)ACT>ACG	p.T85T	POLR1E_uc011lqj.1_Intron|POLR1E_uc003zzy.1_Intron|POLR1E_uc011lqk.1_Intron	NM_022490	NP_071935	Q9GZS1	RPA49_HUMAN	RNA polymerase I associated factor 53	85					rRNA transcription	cell junction|cytoplasm|nucleolus	DNA binding|DNA-directed RNA polymerase activity|protein binding				0				GBM - Glioblastoma multiforme(29;0.00851)|Lung(182;0.229)		TGGGCTGCACTCTTACAGTCC	0.453		NaN											0	0	0	0.003755	0	31	91				
ANKRD20A4	728747	broad.mit.edu	37	9	69423627	69423627	+	Silent	SNP	T	T	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr9:69423627T>C	uc004afn.2	+	15	2035	c.1923T>C	c.(1921-1923)TCT>TCC	p.S641S	uc010mnx.1_5'Flank	NM_001098805	NP_001092275	Q4UJ75	A20A4_HUMAN	ankyrin repeat domain 20 family, member A4	641	Potential.										0						AAGATGTTTCTGTACAAGTAG	0.338		NaN											0	0	0	0.011902	0	34	305				
ZFAND5	7763	broad.mit.edu	37	9	74970975	74970975	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr9:74970975C>G	uc004aiv.2	-	6	814	c.536G>C	c.(535-537)CGT>CCT	p.R179P	ZFAND5_uc010mox.1_Missense_Mutation_p.R76P|ZFAND5_uc010moy.1_Missense_Mutation_p.R179P|ZFAND5_uc004aix.2_Missense_Mutation_p.R179P|ZFAND5_uc004aiw.2_Missense_Mutation_p.R179P|ZFAND5_uc004aiy.2_Missense_Mutation_p.R179P	NM_006007	NP_005998	O76080	ZFAN5_HUMAN	zinc finger, AN1-type domain 5	179	AN1-type.						DNA binding|zinc ion binding				0						GTCAGAGTAACGGTGAAGTCC	0.383		NaN											0	0	0	0.00333	0	23	51				
PCSK5	5125	broad.mit.edu	37	9	78506171	78506171	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr9:78506171G>T	uc004ajz.2	+	1	612	c.74G>T	c.(73-75)TGC>TTC	p.C25F	PCSK5_uc004ajy.2_Missense_Mutation_p.C25F|PCSK5_uc004aka.2_RNA	NM_006200	NP_006191	Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	25					anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			ovary(2)|skin(1)	3						CTCGGGGGCTGCCTGCTCCCC	0.701		NaN											1	0	2.98393e-07	0.00278	3.15022e-07	24	57				
GKAP1	80318	broad.mit.edu	37	9	86403527	86403527	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr9:86403527C>G	uc004amy.2	-	5	923	c.427G>C	c.(427-429)GAG>CAG	p.E143Q	GKAP1_uc004amz.2_Missense_Mutation_p.E143Q|GKAP1_uc011lsu.1_RNA	NM_025211	NP_079487	Q5VSY0	GKAP1_HUMAN	G kinase anchoring protein 1 isoform a	143	Potential.				signal transduction	Golgi apparatus					0						TTTTTGTGCTCTTCATATTCT	0.284		NaN											0	0	0	0.009535	0	30	73				
NTRK2	4915	broad.mit.edu	37	9	87338533	87338533	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr9:87338533A>T	uc004aoa.1	+	9	1567	c.629A>T	c.(628-630)GAA>GTA	p.E210V	NTRK2_uc004anv.1_Missense_Mutation_p.E210V|NTRK2_uc004any.1_Missense_Mutation_p.E210V|NTRK2_uc004anz.1_Missense_Mutation_p.E210V|NTRK2_uc011lsz.1_Missense_Mutation_p.E210V|NTRK2_uc011lta.1_Missense_Mutation_p.E210V|NTRK2_uc004aob.1_Missense_Mutation_p.E210V|NTRK2_uc011ltb.1_Missense_Mutation_p.E54V	NM_001018064	NP_001018074	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	210	Extracellular (Potential).|Ig-like C2-type 1.				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			lung(11)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|liver(1)	16						ACTGTGGAGGAAGGAAAGTCT	0.423		NaN								TSP Lung(25;0.17)			0	0	0	0.00333	0	26	92				
TTLL11	158135	broad.mit.edu	37	9	124751938	124751938	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr9:124751938G>A	uc004blt.1	-	4	1263	c.1075C>T	c.(1075-1077)CGC>TGC	p.R359C	TTLL11_uc011lyl.1_Missense_Mutation_p.R359C|TTLL11_uc004blr.2_RNA|TTLL11_uc011lym.1_Missense_Mutation_p.R36C|TTLL11_uc004blu.1_3'UTR	NM_194252	NP_919228	Q8NHH1	TTL11_HUMAN	tubulin tyrosine ligase-like family, member 11	359	TTL.				protein modification process	cilium|microtubule basal body	tubulin-tyrosine ligase activity				0						CCTGCCAGGCGGATGTCACTG	0.517		NaN											0	0	0	0.01441	0	50	110				
OR1J2	26740	broad.mit.edu	37	9	125273238	125273238	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr9:125273238C>G	uc004bmj.1	+	4	1013	c.158C>G	c.(157-159)TCT>TGT	p.S53C	OR1J2_uc011lyv.1_Missense_Mutation_p.S53C	NM_054107	NP_473448	Q8NGS2	OR1J2_HUMAN	olfactory receptor, family 1, subfamily J,	53	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(3)|pancreas(1)|breast(1)	5						CAGCTGGACTCTCACCTTCAC	0.557		NaN											0	0	0	0.01441	0	64	141				
RALGPS1	9649	broad.mit.edu	37	9	129957439	129957439	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr9:129957439G>A	uc004bqo.1	+	12	1247	c.980G>A	c.(979-981)GGC>GAC	p.G327D	RALGPS1_uc011mac.1_Missense_Mutation_p.G327D|RALGPS1_uc004bqq.3_Missense_Mutation_p.G327D	NM_014636	NP_055451	Q5JS13	RGPS1_HUMAN	Ral GEF with PH domain and SH3 binding motif 1	327					small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity			ovary(1)	1						TCTGTTGCTGGCAGCCTCCCC	0.632		NaN											0	0	0	0.005443	0	27	83				
TTF1	7270	broad.mit.edu	37	9	135275538	135275538	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr9:135275538C>G	uc004cbl.2	-	3	1527	c.1475G>C	c.(1474-1476)GGT>GCT	p.G492A	TTF1_uc011mcp.1_RNA|TTF1_uc004cbm.2_5'UTR	NM_007344	NP_031370	Q15361	TTF1_HUMAN	transcription termination factor, RNA polymerase	492					negative regulation of DNA replication|regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription	nucleolus|nucleoplasm	DNA binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;4.25e-06)|Epithelial(140;9.09e-05)		CACGGCAGAACCCAAATCCGC	0.468		NaN											0	0	0	0.008361	0	32	105				
FCN1	2219	broad.mit.edu	37	9	137804955	137804955	+	Silent	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr9:137804955C>T	uc004cfi.2	-	6	467	c.375G>A	c.(373-375)GGG>GGA	p.G125G		NM_002003	NP_001994	O00602	FCN1_HUMAN	ficolin 1 precursor	125	Fibrinogen C-terminal.				opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding			large_intestine(1)|ovary(1)	2		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)		TCAGGAAATACCCCCGGTCTA	0.677		NaN											0	0	0	0.006214	0	10	12				
MXRA5	25878	broad.mit.edu	37	X	3241401	3241401	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chrX:3241401G>C	uc004crg.3	-	5	2482	c.2325C>G	c.(2323-2325)AAC>AAG	p.N775K		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	775						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TAATCTGTTTGTTTGCCATGT	0.443		NaN											0	0	0	0.01441	0	46	30				
KLHL15	80311	broad.mit.edu	37	X	24024257	24024257	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chrX:24024257T>C	uc004dba.3	-	3	810	c.554A>G	c.(553-555)GAT>GGT	p.D185G		NM_030624	NP_085127	Q96M94	KLH15_HUMAN	kelch-like 15	185	BACK.									ovary(1)|breast(1)	2						ATGATCATTATCCAAGTAAGA	0.478		NaN											0	0	0	0.001168	0	5	96				
KIAA2022	340533	broad.mit.edu	37	X	73961258	73961258	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chrX:73961258G>C	uc004eby.2	-	3	3751	c.3134C>G	c.(3133-3135)CCA>CGA	p.P1045R		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	1045					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						CTCCTTTAGTGGTGCTATCTC	0.502		NaN											0	0	0	0.004289	0	38	21				
MAGEE1	57692	broad.mit.edu	37	X	75649899	75649899	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chrX:75649899C>T	uc004ecm.1	+	1	1783	c.1576C>T	c.(1576-1578)CGC>TGC	p.R526C		NM_020932	NP_065983	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	526	MAGE 1.					dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|ovary(1)|pancreas(1)|skin(1)	6						TAAAGAATATCGCAACCAGTT	0.478		NaN											0	0	0	0.00278	0	22	5				
TMEM164	84187	broad.mit.edu	37	X	109416577	109416577	+	Silent	SNP	C	C	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chrX:109416577C>A	uc004eom.2	+	7	1111	c.792C>A	c.(790-792)ACC>ACA	p.T264T	TMEM164_uc004eol.2_Silent_p.T115T|TMEM164_uc010npq.2_Silent_p.T225T|TMEM164_uc004eon.1_5'Flank	NM_032227	NP_115603	Q5U3C3	TM164_HUMAN	transmembrane protein 164 isoform b	264	Helical; (Potential).					integral to membrane				large_intestine(1)|lung(1)|skin(1)	3						CTCTCATGACCATGACCCACG	0.532		NaN											1	0	6.68952e-21	0.013114	7.5534e-21	44	29				
XIAP	331	broad.mit.edu	37	X	123040977	123040977	+	Silent	SNP	G	G	A	rs61757634		TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chrX:123040977G>A	uc010nqu.2	+	7	1566	c.1440G>A	c.(1438-1440)AAG>AAA	p.K480K	XIAP_uc004etx.2_Silent_p.K480K|XIAP_uc010nqv.2_Silent_p.K106K	NM_001167	NP_001158	P98170	XIAP_HUMAN	baculoviral IAP repeat-containing protein 4	480	RING-type.				anti-apoptosis|apoptosis|induction of apoptosis by intracellular signals|response to DNA damage stimulus	cytosol	caspase inhibitor activity|ligase activity|protein binding|zinc ion binding			ovary(1)|lung(1)	2						CAGTTGACAAGTGTCCCATGT	0.343		NaN							X-linked_Lymphoproliferative_syndrome				0	0	0	0.00623	0	41	22				
MAGEC2	51438	broad.mit.edu	37	X	141290659	141290659	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chrX:141290659G>A	uc004fbu.1	-	3	1463	c.1115C>T	c.(1114-1116)TCT>TTT	p.S372F		NM_016249	NP_057333	Q9UBF1	MAGC2_HUMAN	melanoma antigen family C, 2	372						cytoplasm|nucleus				breast(2)	2	Acute lymphoblastic leukemia(192;6.56e-05)					ACTTCACTCAGAAAAGGAGAC	0.512		NaN								HNSCC(46;0.14)			0	0	0	0.007835	0	40	22				
SLITRK4	139065	broad.mit.edu	37	X	142718330	142718330	+	Silent	SNP	G	G	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chrX:142718330G>A	uc004fbx.2	-	2	971	c.595C>T	c.(595-597)CTG>TTG	p.L199L	SLITRK4_uc004fby.2_Silent_p.L199L	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	199	Extracellular (Potential).|LRR 6.					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					ATGTGTTCCAGAACCCCGATA	0.443		NaN											0	0	0	0.01441	0	48	35				
MARK2	2011	broad.mit.edu	37	11	63663087	63663089	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr11:63663087_63663089delCTC	uc001nxw.2	+	3	849_851	c.270_272delCTC	c.(268-273)AACTCC>AAC	p.S93del	MARK2_uc001nxx.2_In_Frame_Del_p.S93del|MARK2_uc001nxy.2_In_Frame_Del_p.S93del|MARK2_uc001nxv.3_In_Frame_Del_p.S93del|MARK2_uc001nxz.3_In_Frame_Del_p.S60del|MARK2_uc009yoy.2_In_Frame_Del_p.S60del	NM_001039469	NP_001034558	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	93	Protein kinase.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity	p.N57K(1)		stomach(1)|ovary(1)|lung(1)	3						CTCAACTGAACTCCTCCAGCCTC	0.35		NaN											NaN	NaN	NaN	NaN	NaN	29	173	---		---	---
C12orf35	55196	broad.mit.edu	37	12	32138036	32138037	+	Frame_Shift_Ins	INS	-	-	TA			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:32138036_32138037insTA	uc001rks.2	+	4	4561_4562	c.4147_4148insTA	c.(4147-4149)TTAfs	p.L1383fs	C12orf35_uc001rkt.2_5'Flank	NM_018169	NP_060639	Q9HCM1	CL035_HUMAN	hypothetical protein LOC55196	1383										ovary(1)|skin(1)	2	all_cancers(9;3.36e-11)|all_epithelial(9;2.56e-11)|all_lung(12;5.67e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0114)			AGGGAACGTATTAGATATGGAA	0.347		NaN											NaN	NaN	NaN	NaN	NaN	11	66	---		---	---
MLL2	8085	broad.mit.edu	37	12	49424468	49424475	+	Frame_Shift_Del	DEL	GACTGGGC	GACTGGGC	-			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08			GACTGGGC	-	GACTGGGC	GACTGGGC		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr12:49424468_49424475delGACTGGGC	uc001rta.3	-	41	13748_13755	c.13748_13755delGCCCAGTC	c.(13747-13755)TGCCCAGTCfs	p.C4583fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	4583_4585					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TCTGCCCATTGACTGGGCAGCCACTGCC	0.577		NaN	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			NaN	NaN	NaN	NaN	NaN	10	29	---	Valid	---	---
RB1	5925	broad.mit.edu	37	13	49039151	49039160	+	Frame_Shift_Del	DEL	GATCAAAGAA	GATCAAAGAA	-	rs3092905		TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08			GATCAAAGAA	-	GATCAAAGAA	GATCAAAGAA		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr13:49039151_49039160delGATCAAAGAA	uc001vcb.2	+	22	2395_2404	c.2229_2238delGATCAAAGAA	c.(2227-2238)TTGATCAAAGAAfs	p.L743fs		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	743_746	Pocket; binds T and E1A.|Domain B.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(8)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	AACGTGTTTTGATCAAAGAAGAGGAGTATG	0.286		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			NaN	NaN	NaN	NaN	NaN	7	39	---	Valid	---	---
FOXA1	3169	broad.mit.edu	37	14	38061854	38061862	+	In_Frame_Del	DEL	GTTCATGGA	GTTCATGGA	-			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08			GTTCATGGA	-	GTTCATGGA	GTTCATGGA		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr14:38061854_38061862delGTTCATGGA	uc001wuf.2	-	2	439_447	c.127_135delTCCATGAAC	c.(127-135)TCCATGAACdel	p.SMN43del	FOXA1_uc010tpz.1_In_Frame_Del_p.SMN10del	NM_004496	NP_004487	P55317	FOXA1_HUMAN	forkhead box A1	43_45					chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding				0	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		TCATGTAGGTGTTCATGGAGTTCATGGAG	0.608		NaN											NaN	NaN	NaN	NaN	NaN	21	89	---	Valid	---	---
CORO1A	11151	broad.mit.edu	37	16	30198259	30198260	+	Frame_Shift_Ins	INS	-	-	T			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr16:30198259_30198260insT	uc002dww.2	+	4	566_567	c.444_445insT	c.(442-447)CTCAGTfs	p.L148fs	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|CORO1A_uc010vej.1_Frame_Shift_Ins_p.L148fs|CORO1A_uc010bzq.2_Frame_Shift_Ins_p.L148fs|CORO1A_uc010bzr.2_Frame_Shift_Ins_p.L148fs|CORO1A_uc002dwx.2_Frame_Shift_Ins_p.L42fs|CORO1A_uc002dwy.1_5'UTR|LOC606724_uc002dwz.1_5'Flank	NM_007074	NP_009005	P31146	COR1A_HUMAN	coronin, actin binding protein, 1A	148_149	WD 3.				cell-substrate adhesion|innate immune response|leukocyte chemotaxis|negative regulation of actin nucleation|phagolysosome assembly|positive chemotaxis|regulation of cell shape|uropod organization	actin filament|cortical actin cytoskeleton|lamellipodium|phagocytic cup|phagocytic vesicle membrane	actin filament binding|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein homodimerization activity				0						ACGTGCTGCTCAGTGCAGGTGC	0.673		NaN											NaN	NaN	NaN	NaN	NaN	11	42	---		---	---
ZNF750	79755	broad.mit.edu	37	17	80789041	80789042	+	Frame_Shift_Ins	INS	-	-	A			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr17:80789041_80789042insA	uc002kga.2	-	2	1600_1601	c.1289_1290insT	c.(1288-1290)CTGfs	p.L430fs	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	430						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			AGAGGTCGTACAGGCCTTCGCA	0.624		NaN											NaN	NaN	NaN	NaN	NaN	24	86	---		---	---
EPB41L3	23136	broad.mit.edu	37	18	5406924	5406928	+	Frame_Shift_Del	DEL	TTGGT	TTGGT	-			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr18:5406924_5406928delTTGGT	uc002kmt.1	-	16	2283_2287	c.2197_2201delACCAA	c.(2197-2202)ACCAACfs	p.T733fs	EPB41L3_uc010wzh.1_Frame_Shift_Del_p.T564fs|EPB41L3_uc002kmu.1_Frame_Shift_Del_p.T552fs|EPB41L3_uc010dkq.1_Frame_Shift_Del_p.T443fs|EPB41L3_uc002kms.1_Frame_Shift_Del_p.T5fs|EPB41L3_uc010wze.1_Frame_Shift_Del_p.T5fs|EPB41L3_uc010wzf.1_Frame_Shift_Del_p.T5fs|EPB41L3_uc010wzg.1_Frame_Shift_Del_p.T5fs|EPB41L3_uc010dkr.2_Frame_Shift_Del_p.T125fs	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	733_734	Spectrin--actin-binding (Potential).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						CTCGCTAATGTTGGTTTGATGTTTC	0.429		NaN											NaN	NaN	NaN	NaN	NaN	31	100	---		---	---
MTHFD2	10797	broad.mit.edu	37	2	74432891	74432897	+	Frame_Shift_Del	DEL	GGCAGGA	GGCAGGA	-	rs6758485		TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr2:74432891_74432897delGGCAGGA	uc002skk.2	+	2	240_246	c.161_167delGGCAGGA	c.(160-168)CGGCAGGAGfs	p.R54fs	MTHFD2_uc002skj.2_5'UTR|MTHFD2_uc010yro.1_Intron|MTHFD2_uc010ffb.2_Frame_Shift_Del_p.R54fs|MTHFD2_uc010yrp.1_Intron	NM_006636	NP_006627	P13995	MTDC_HUMAN	methylenetetrahydrofolate dehydrogenase 2	54_56					folic acid-containing compound biosynthetic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	magnesium ion binding|methenyltetrahydrofolate cyclohydrolase activity|methylenetetrahydrofolate dehydrogenase (NAD+) activity|methylenetetrahydrofolate dehydrogenase (NADP+) activity|phosphate binding|protein binding				0					NADH(DB00157)|Tetrahydrofolic acid(DB00116)	CAGGAAGTGCGGCAGGAGGTAGAAGAG	0.498		NaN											NaN	NaN	NaN	NaN	NaN	30	42	---		---	---
EIF4A2	1974	broad.mit.edu	37	3	186503971	186503974	+	Frame_Shift_Del	DEL	TGTT	TGTT	-			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chr3:186503971_186503974delTGTT	uc003fqs.2	+	6	575_578	c.536_539delTGTT	c.(535-540)ATGTTTfs	p.M179fs	EIF4A2_uc003fqt.2_RNA|EIF4A2_uc003fqu.2_Frame_Shift_Del_p.M180fs|EIF4A2_uc003fqv.2_Frame_Shift_Del_p.M84fs|EIF4A2_uc003fqw.2_Frame_Shift_Del_p.M84fs|EIF4A2_uc011bsb.1_Frame_Shift_Del_p.M52fs|MIR1248_hsa-mir-1248|MI0006383_5'Flank|SNORA81_uc010hyv.1_5'Flank|SNORA63_uc010hyw.1_5'Flank|SNORA4_uc010hyx.1_5'Flank	NM_001967	NP_001958	Q14240	IF4A2_HUMAN	eukaryotic translation initiation factor 4A2	179_180	Helicase ATP-binding.				interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	ATP binding|ATP-dependent helicase activity|protein binding|translation initiation factor activity			ovary(2)|breast(2)	4	all_cancers(143;2.68e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.07e-20)	GBM - Glioblastoma multiforme(93;0.0704)		TGGATCAAAATGTTTGTTTTGGAT	0.319		NaN	T	BCL6	NHL								NaN	NaN	NaN	NaN	NaN	40	46	---		---	---
TSPYL2	64061	broad.mit.edu	37	X	53111922	53111923	+	Frame_Shift_Ins	INS	-	-	G			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chrX:53111922_53111923insG	uc004drw.2	+	1	374_375	c.242_243insG	c.(241-243)GAGfs	p.E81fs	TSPYL2_uc004drv.2_Frame_Shift_Ins_p.E81fs|TSPYL2_uc004drx.1_5'Flank	NM_022117	NP_071400	Q9H2G4	TSYL2_HUMAN	TSPY-like 2	81					cell cycle|chromatin modification|negative regulation of cell cycle|negative regulation of cell growth|negative regulation of DNA replication|nucleosome assembly|regulation of protein kinase activity|regulation of signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	protein binding|rDNA binding				0						ATTCTCGAGGAGGGGGGGATCC	0.693		NaN											NaN	NaN	NaN	NaN	NaN	5	4	---		---	---
MED12	9968	broad.mit.edu	37	X	70339253	70339258	+	In_Frame_Del	DEL	GGTTTC	GGTTTC	-			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chrX:70339253_70339258delGGTTTC	uc004dyy.2	+	2	329_334	c.130_135delGGTTTC	c.(130-135)GGTTTCdel	p.GF44del	MED12_uc011mpq.1_In_Frame_Del_p.GF44del|MED12_uc004dyz.2_In_Frame_Del_p.GF44del|MED12_uc004dza.2_5'Flank	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	44_45					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					TGTAAAACAAGGTTTCAATAACCAGC	0.413		NaN											NaN	NaN	NaN	NaN	NaN	5	3	---		---	---
STAG2	10735	broad.mit.edu	37	X	123179177	123179178	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-FD-A3SL-01A-21D-A22Z-08	TCGA-FD-A3SL-10A-01D-A22Z-08			AC	-	AC	AC		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	90e57a6b-edfb-4aed-b5e0-4e607daec98a	97cfcabd-db3e-4e43-b83b-89994611ceb3	g.chrX:123179177_123179178delAC	uc004etz.3	+	7	965_966	c.626_627delAC	c.(625-627)GACfs	p.D209fs	STAG2_uc004eua.2_Frame_Shift_Del_p.D209fs|STAG2_uc004eub.2_Frame_Shift_Del_p.D209fs|STAG2_uc004euc.2_Frame_Shift_Del_p.D209fs|STAG2_uc004eud.2_Frame_Shift_Del_p.D209fs|STAG2_uc004eue.2_Frame_Shift_Del_p.D209fs	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	209					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						GGATTGTCTGACTCACAAGTCA	0.361		NaN											NaN	NaN	NaN	NaN	NaN	111	65	---	Valid	---	---
