Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_by_all_platform	validation_method	validation_tumor_sample
DNAJC11	55735	broad.mit.edu	37	1	6696194	6696194	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:6696194A>G	uc001aof.2	-	15	1743	c.1637T>C	c.(1636-1638)CTC>CCC	p.L546P	DNAJC11_uc010nzt.1_Intron|DNAJC11_uc001aog.2_Missense_Mutation_p.L494P|DNAJC11_uc010nzu.1_Missense_Mutation_p.L456P	NM_018198	NP_060668	Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	546					protein folding		heat shock protein binding|unfolded protein binding			ovary(1)|skin(1)	2	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		TGGTATCCGGAGGGCCTCACT	0.607		NaN											0	0	0	0.00308	0	8	38				
WASF2	10163	broad.mit.edu	37	1	27736473	27736473	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:27736473G>A	uc001bof.1	-	8	1268	c.1052C>T	c.(1051-1053)TCA>TTA	p.S351L	WASF2_uc010ofl.1_Intron	NM_006990	NP_008921	Q9Y6W5	WASF2_HUMAN	WAS protein family, member 2	351					actin cytoskeleton organization|G-protein signaling, coupled to cAMP nucleotide second messenger	actin cytoskeleton|lamellipodium	actin binding			skin(2)|ovary(1)	3		all_lung(284;1.06e-05)|Lung NSC(340;1.86e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.00503)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0446)|OV - Ovarian serous cystadenocarcinoma(117;2.46e-25)|Colorectal(126;1.7e-08)|COAD - Colon adenocarcinoma(152;2e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00139)|KIRC - Kidney renal clear cell carcinoma(1967;0.00204)|STAD - Stomach adenocarcinoma(196;0.00325)|READ - Rectum adenocarcinoma(331;0.0481)		AGATGGGGGTGAGGGTGGTGG	0.637		NaN											0	0	0	0.020292	0	13	55				
PGM1	5236	broad.mit.edu	37	1	64117350	64117350	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:64117350G>A	uc001dbh.2	+	9	1504	c.1291G>A	c.(1291-1293)GAG>AAG	p.E431K	PGM1_uc010ooy.1_Missense_Mutation_p.E234K|PGM1_uc010ooz.1_Missense_Mutation_p.E449K	NM_002633	NP_002624	P36871	PGM1_HUMAN	phosphoglucomutase 1	431					cellular calcium ion homeostasis|galactose catabolic process|glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity			ovary(2)|kidney(1)	3						GTATGATTACGAGGAGGTGGA	0.498		NaN											0	0	0	0.006214	0	10	20				
GBP6	163351	broad.mit.edu	37	1	89845982	89845982	+	Silent	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:89845982G>A	uc001dnf.2	+	6	937	c.663G>A	c.(661-663)AGG>AGA	p.R221R	GBP6_uc010ost.1_Silent_p.R91R	NM_198460	NP_940862	Q6ZN66	GBP6_HUMAN	guanylate binding protein family, member 6	221							GTP binding|GTPase activity			ovary(2)	2		Lung NSC(277;0.0908)		all cancers(265;0.0108)|Epithelial(280;0.0398)		ATTTTCCCAGGGAGTGCATCA	0.408		NaN											0	0	0	0.00308	0	7	74				
SLC6A17	388662	broad.mit.edu	37	1	110709723	110709723	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:110709723G>A	uc009wfq.2	+	2	633	c.172G>A	c.(172-174)GAG>AAG	p.E58K		NM_001010898	NP_001010898	Q9H1V8	S6A17_HUMAN	solute carrier family 6, member 17	58	Cytoplasmic (Potential).				alanine transport|glycine transport|leucine transport|proline transport	cell junction|integral to plasma membrane|synaptic vesicle membrane	neurotransmitter:sodium symporter activity			ovary(1)|pancreas(1)	2		all_cancers(81;9.9e-06)|all_epithelial(167;3.24e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0282)|Epithelial(280;0.0372)|all cancers(265;0.0378)|Colorectal(144;0.0438)|LUSC - Lung squamous cell carcinoma(189;0.151)|COAD - Colon adenocarcinoma(174;0.151)		GCTGGATGCAGAGGACCGGCC	0.612		NaN											0	0	0	0.014758	0	5	15				
BCAS2	10286	broad.mit.edu	37	1	115118216	115118216	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:115118216G>T	uc001efa.2	-	4	467	c.414C>A	c.(412-414)TAC>TAA	p.Y138*	DENND2C_uc001eez.2_RNA	NM_005872	NP_005863	O75934	SPF27_HUMAN	breast carcinoma amplified sequence 2	138	Potential.				mRNA processing|RNA splicing, via transesterification reactions	nucleolus|spliceosomal complex	protein binding			large_intestine(1)	1	all_epithelial(7;9.54e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;4.64e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTTACTCATTGTATACTTTCC	0.274		NaN											1	0	1.56452e-12	0.007413	1.70444e-12	19	49				
PHGDH	26227	broad.mit.edu	37	1	120254678	120254678	+	Silent	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:120254678C>T	uc001ehz.2	+	1	260	c.33C>T	c.(31-33)ATC>ATT	p.I11I	PHGDH_uc009whl.2_5'UTR|PHGDH_uc009whm.2_5'UTR|PHGDH_uc001eia.2_Silent_p.I11I|PHGDH_uc009whn.2_Silent_p.I11I	NM_006623	NP_006614	O43175	SERA_HUMAN	phosphoglycerate dehydrogenase	11					brain development|L-serine biosynthetic process		electron carrier activity|NAD binding|phosphoglycerate dehydrogenase activity			ovary(1)	1	all_cancers(5;1.18e-09)|all_epithelial(5;2.16e-10)|Melanoma(3;1.93e-05)|all_neural(166;0.219)	all_lung(203;3.66e-05)|Lung NSC(69;0.000202)|all_epithelial(167;0.0347)		Lung(183;0.0111)|LUSC - Lung squamous cell carcinoma(189;0.0593)	NADH(DB00157)	AAGTGCTCATCAGTGACAGCC	0.552		NaN											0	0	0	0.016723	0	13	53				
GON4L	54856	broad.mit.edu	37	1	155774915	155774915	+	Silent	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:155774915G>A	uc001flz.2	-	11	1567	c.1470C>T	c.(1468-1470)CTC>CTT	p.L490L	GON4L_uc001fly.1_Silent_p.L490L|GON4L_uc009wrh.1_Silent_p.L490L|GON4L_uc001fma.1_Silent_p.L490L|GON4L_uc001fmc.2_Silent_p.L490L|GON4L_uc001fmd.3_Silent_p.L490L|GON4L_uc009wri.2_Silent_p.L76L|GON4L_uc009wrj.1_Silent_p.L5L|GON4L_uc001fme.2_Silent_p.L318L|GON4L_uc001fmf.2_Silent_p.L184L	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	490					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					GAAATGCAATGAGACTGTCAT	0.458		NaN											0	0	0	0.007291	0	28	56				
BTG2	7832	broad.mit.edu	37	1	203276391	203276391	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:203276391C>T	uc001gzq.2	+	2	373	c.302C>T	c.(301-303)ACC>ATC	p.T101I	FMOD_uc010pqi.1_Intron|uc009xao.1_5'Flank|uc001gzp.1_5'Flank|BTG2_uc009xap.1_RNA	NM_006763	NP_006754	P78543	BTG2_HUMAN	B-cell translocation gene 2	101					DNA repair|neuron projection development|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(1)|kidney(1)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.203)			AGCGAGCTGACCCTGTGGGTG	0.642		NaN											0	0	0	0.021553	0	6	43		Valid		
RGS7	6000	broad.mit.edu	37	1	241094020	241094020	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:241094020A>T	uc001hyv.2	-	6	712	c.382T>A	c.(382-384)TAT>AAT	p.Y128N	RGS7_uc010pyh.1_Missense_Mutation_p.Y102N|RGS7_uc010pyj.1_Missense_Mutation_p.Y44N|RGS7_uc001hyu.2_Missense_Mutation_p.Y128N|RGS7_uc009xgn.1_Intron|RGS7_uc001hyw.2_Missense_Mutation_p.Y128N	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	128					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			CACTGACCATAATCTGTGTTT	0.373		NaN											0	0	0	0.01441	0	131	96				
OR6F1	343169	broad.mit.edu	37	1	247875460	247875460	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:247875460A>G	uc001idj.1	-	1	598	c.598T>C	c.(598-600)TTT>CTT	p.F200L		NM_001005286	NP_001005286	Q8NGZ6	OR6F1_HUMAN	olfactory receptor, family 6, subfamily F,	200	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.0168)			GCAATCACAAAGGCCACAAGC	0.537		NaN											0	0	0	0.007413	0	20	144				
OR2T1	26696	broad.mit.edu	37	1	248569879	248569879	+	Missense_Mutation	SNP	T	T	A	rs138350213		TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:248569879T>A	uc010pzm.1	+	1	584	c.584T>A	c.(583-585)ATA>AAA	p.I195K		NM_030904	NP_112166	O43869	OR2T1_HUMAN	olfactory receptor, family 2, subfamily T,	195	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGGATGATTATAGCAGGTTCC	0.537		NaN											0	0	0	0.020292	0	15	139				
ARHGAP21	57584	broad.mit.edu	37	10	24873643	24873643	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr10:24873643G>A	uc001isb.2	-	26	6062	c.5575C>T	c.(5575-5577)CGC>TGC	p.R1859C	ARHGAP21_uc010qdb.1_RNA	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1858	Interaction with CTNNA1.				signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8						GTACTGGTGCGTAGGCGTTCC	0.527		NaN											0	0	0	0.006122	0	18	74				
ARHGAP21	57584	broad.mit.edu	37	10	24873919	24873919	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr10:24873919C>G	uc001isb.2	-	26	5786	c.5299G>C	c.(5299-5301)GAT>CAT	p.D1767H	ARHGAP21_uc010qdb.1_RNA	NM_020824	NP_065875	Q5T5U3	RHG21_HUMAN	Rho GTPase activating protein 21	1766	Interaction with CTNNA1.				signal transduction	cell junction|cytoplasmic vesicle membrane|cytoskeleton|Golgi membrane	GTPase activator activity|protein binding			ovary(7)|pancreas(1)	8						TTTAACCGATCTGCTATTTTC	0.463		NaN											0	0	0	0.006122	0	19	86				
ZNF438	220929	broad.mit.edu	37	10	31137576	31137576	+	Silent	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr10:31137576C>T	uc010qdz.1	-	7	2193	c.1758G>A	c.(1756-1758)CTG>CTA	p.L586L	ZNF438_uc001ivn.2_Silent_p.L537L|ZNF438_uc010qdy.1_Silent_p.L576L|ZNF438_uc001ivo.3_Silent_p.L150L|ZNF438_uc009xlg.2_Silent_p.L586L|ZNF438_uc001ivp.3_Silent_p.L576L|ZNF438_uc010qea.1_Silent_p.L586L|ZNF438_uc010qeb.1_Silent_p.L586L|ZNF438_uc010qec.1_Silent_p.L150L	NM_182755	NP_877432	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438 isoform a	586	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2		Prostate(175;0.0587)				GCACTTCTTTCAGATGGCCAA	0.478		NaN											0	0	0	0.008361	0	31	88				
LIPA	3988	broad.mit.edu	37	10	91007301	91007301	+	Missense_Mutation	SNP	C	C	T	rs145756015		TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr10:91007301C>T	uc001kga.3	-	2	273	c.105G>A	c.(103-105)ATG>ATA	p.M35I	LIPA_uc001kgb.3_Intron|LIPA_uc001kgc.3_Intron|LIPA_uc009xtq.2_Missense_Mutation_p.M35I	NM_000235	NP_000226	P38571	LICH_HUMAN	lipase A precursor	35					lipid catabolic process	lysosome	lipase activity|sterol esterase activity				0		Colorectal(252;0.0162)		GBM - Glioblastoma multiforme(2;0.00406)		TTACCACATTCATGTTTGTTT	0.438		NaN											0	0	0	0.014758	0	4	21				
CPXM2	119587	broad.mit.edu	37	10	125526589	125526589	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr10:125526589T>C	uc001lhk.1	-	10	1704	c.1379A>G	c.(1378-1380)AAC>AGC	p.N460S	CPXM2_uc001lhj.2_RNA	NM_198148	NP_937791	Q8N436	CPXM2_HUMAN	carboxypeptidase X (M14 family), member 2	460					cell adhesion|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.174)|Colorectal(57;0.178)|Glioma(114;0.222)|all_neural(114;0.226)|Lung NSC(174;0.233)		COAD - Colon adenocarcinoma(40;0.212)|Colorectal(40;0.237)		GAGCAGCGTGTTTAAATCAGG	0.527		NaN											0	0	0	0.016723	0	12	57				
EBF3	253738	broad.mit.edu	37	10	131640400	131640400	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr10:131640400G>A	uc001lki.1	-	13	1384	c.1325C>T	c.(1324-1326)ACG>ATG	p.T442M		NM_001005463	NP_001005463	Q9H4W6	COE3_HUMAN	early B-cell factor 3	451					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|metal ion binding|protein binding			central_nervous_system(1)|pancreas(1)	2		all_cancers(35;1.8e-08)|all_epithelial(44;8.26e-08)|Lung NSC(174;0.0091)|all_lung(145;0.0123)|Breast(234;0.039)|all_neural(114;0.0722)|Colorectal(57;0.0764)		OV - Ovarian serous cystadenocarcinoma(35;0.00513)		GGCTTGTGACGTCTCTGACAC	0.597		NaN											0	0	0	0.014323	0	23	73				
PAOX	196743	broad.mit.edu	37	10	135202547	135202547	+	Silent	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr10:135202547C>T	uc001lmv.2	+	5	1289	c.1209C>T	c.(1207-1209)CTC>CTT	p.L403L	PAOX_uc001lmw.2_RNA|PAOX_uc001lmx.2_Silent_p.L403L|PAOX_uc001lmy.2_Missense_Mutation_p.S319L|PAOX_uc001lmz.2_RNA|PAOX_uc001lna.2_RNA|PAOX_uc001lnb.2_RNA|PAOX_uc001lnc.2_RNA	NM_152911	NP_690875	Q6QHF9	PAOX_HUMAN	polyamine oxidase isoform 1	541					polyamine biosynthetic process|xenobiotic metabolic process	peroxisomal matrix	polyamine oxidase activity				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;4.39e-07)|OV - Ovarian serous cystadenocarcinoma(35;1.21e-06)|Epithelial(32;1.94e-06)		TTCTGTGTCTCACCCAAGTGC	0.502		NaN											0	0	0	0.016723	0	13	210				
CCKBR	887	broad.mit.edu	37	11	6290930	6290930	+	Silent	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr11:6290930C>T	uc001mcp.2	+	2	376	c.183C>T	c.(181-183)TAC>TAT	p.Y61Y	CCKBR_uc001mcq.2_Translation_Start_Site|CCKBR_uc001mcr.2_Silent_p.Y61Y|CCKBR_uc001mcs.2_Silent_p.Y61Y	NM_176875	NP_795344	P32239	GASR_HUMAN	cholecystokinin B receptor	61	Helical; Name=1; (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			lung(5)|ovary(2)|breast(1)	8		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	TCACTCTTTACGCAGTGATCT	0.532		NaN											0	0	0	0.028581	0	17	64				
CD6	923	broad.mit.edu	37	11	60781397	60781397	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr11:60781397C>T	uc001nqq.2	+	8	1521	c.1298C>T	c.(1297-1299)CCC>CTC	p.P433L	CD6_uc001nqp.2_Missense_Mutation_p.P433L|CD6_uc001nqr.2_Intron|CD6_uc001nqs.2_RNA|CD6_uc001nqt.2_Missense_Mutation_p.P433L	NM_006725	NP_006716	P30203	CD6_HUMAN	CD6 molecule precursor	433	Cytoplasmic (Potential).				cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			pancreas(1)	1						TCAGCCCTCCCCGTAATGGTG	0.557		NaN											0	0	0	0.021553	0	6	29				
OMP	4975	broad.mit.edu	37	11	76814045	76814045	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr11:76814045C>T	uc010rsk.1	+	1	160	c.160C>T	c.(160-162)CGC>TGC	p.R54C	CAPN5_uc001oxx.2_Intron|CAPN5_uc009yup.2_Intron|CAPN5_uc009yuq.2_Intron|CAPN5_uc001oxy.2_Intron	NM_006189	NP_006180	P47874	OMP_HUMAN	olfactory marker protein	54					sensory perception of smell|synaptic transmission						0						GTCTGTGTACCGCCTCAACTT	0.637		NaN											0	0	0	0.021553	0	6	30				
IQSEC3	440073	broad.mit.edu	37	12	266745	266745	+	Silent	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr12:266745C>T	uc001qhw.1	+	4	1425	c.1419C>T	c.(1417-1419)CCC>CCT	p.P473P	IQSEC3_uc001qhu.1_Silent_p.P473P	NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	776	SEC7.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		TCCACAACCCCGACACCATCT	0.602		NaN											0	0	0	0.014758	0	5	84				
GUCY2C	2984	broad.mit.edu	37	12	14767865	14767865	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr12:14767865C>T	uc001rcd.2	-	26	3120	c.2983G>A	c.(2983-2985)GAG>AAG	p.E995K		NM_004963	NP_004954	P25092	GUC2C_HUMAN	guanylate cyclase 2C precursor	995	Cytoplasmic (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			ovary(4)|skin(2)	6						TAGGTAGTCTCATTTCCTCTT	0.483		NaN											0	0	0	0.009096	0	4	21				
ANKS1B	56899	broad.mit.edu	37	12	100200436	100200436	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr12:100200436C>T	uc001tge.1	-	4	832	c.415G>A	c.(415-417)GGA>AGA	p.G139R	ANKS1B_uc001tgf.1_Intron|ANKS1B_uc009ztt.1_Missense_Mutation_p.G139R	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	139	ANK 4.					Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		TCTGAGTGTCCATATTGAGCT	0.398		NaN											0	0	0	0.008291	0	11	35				
ZCCHC8	55596	broad.mit.edu	37	12	122958344	122958344	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr12:122958344C>G	uc001ucn.2	-	14	1955	c.1824G>C	c.(1822-1824)CAG>CAC	p.Q608H	ZCCHC8_uc001ucl.2_Missense_Mutation_p.Q219H|ZCCHC8_uc001ucm.2_Missense_Mutation_p.Q370H|ZCCHC8_uc009zxp.2_Missense_Mutation_p.Q370H|ZCCHC8_uc009zxq.2_Missense_Mutation_p.Q370H	NM_017612	NP_060082	Q6NZY4	ZCHC8_HUMAN	zinc finger, CCHC domain containing 8	608						catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)		CTTTTTCCTTCTGACAAAGTG	0.493		NaN											0	0	0	0.01441	0	52	147				
FGF14	2259	broad.mit.edu	37	13	102527614	102527614	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr13:102527614A>G	uc001vpe.2	-	2	226	c.226T>C	c.(226-228)TAT>CAT	p.Y76H	FGF14_uc001vpf.2_Missense_Mutation_p.Y81H	NM_004115	NP_004106	Q92915	FGF14_HUMAN	fibroblast growth factor 14 isoform 1A	76					cell death|cell-cell signaling|JNK cascade|nervous system development|signal transduction	nucleus	growth factor activity|heparin binding			ovary(2)|lung(1)|large_intestine(1)	4	all_neural(89;0.0239)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TGCCTGCAATATAACCTGGTC	0.448		NaN											0	0	0	0.016723	0	12	45				
MBIP	51562	broad.mit.edu	37	14	36789701	36789701	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr14:36789701C>T	uc001wtm.2	-	1	182	c.94G>A	c.(94-96)GAA>AAA	p.E32K	MBIP_uc001wto.2_Missense_Mutation_p.E32K|MBIP_uc010tpy.1_5'UTR|MBIP_uc001wtn.2_Missense_Mutation_p.E32K	NM_016586	NP_057670	Q9NS73	MBIP1_HUMAN	MAP3K12 binding inhibitory protein 1 isoform 1	32					histone H3 acetylation|inactivation of MAPK activity involved in osmosensory signaling pathway	Ada2/Gcn5/Ada3 transcription activator complex|cytoplasm|nucleolus	identical protein binding|protein kinase inhibitor activity				0	all_cancers(3;1.55e-52)|all_epithelial(1;2.69e-62)|Breast(36;0.0505)|Hepatocellular(127;0.158)|Esophageal squamous(585;0.164)		Lung(8;1.28e-07)|LUAD - Lung adenocarcinoma(9;3e-07)|Epithelial(34;0.0303)|all cancers(34;0.0781)	GBM - Glioblastoma multiforme(112;0.0191)		CGAAAGATTTCGTAGAGCACC	0.567		NaN											0	0	0	0.004482	0	9	30				
SFTA3	253970	broad.mit.edu	37	14	36946212	36946212	+	Silent	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr14:36946212C>T	uc001wtr.2	-	3	857	c.225G>A	c.(223-225)ACG>ACA	p.T75T	SFTA3_uc001wtq.2_RNA|SFTA3_uc001wts.2_RNA	NM_001101341	NP_001094811	P0C7M3	SFTA3_HUMAN	surfactant associated 3	75											0						GTGACAGCGTCGTGGGATGCA	0.532		NaN											0	0	0	0.006214	0	8	111				
DAAM1	23002	broad.mit.edu	37	14	59798179	59798179	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr14:59798179C>T	uc001xdz.1	+	14	1938	c.1813C>T	c.(1813-1815)CAG>TAG	p.Q605*	DAAM1_uc001xea.1_Nonsense_Mutation_p.Q605*	NM_014992	NP_055807	Q9Y4D1	DAAM1_HUMAN	dishevelled-associated activator of	605	FH2.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.165)		AAGCATTCCTCAGCCCACAAA	0.453		NaN											0	0	0	0.01892	0	25	81				
CHD9	80205	broad.mit.edu	37	16	53348844	53348844	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr16:53348844A>G	uc002ehb.2	+	35	7636	c.7472A>G	c.(7471-7473)AAT>AGT	p.N2491S	CHD9_uc002egy.2_Missense_Mutation_p.N2475S|CHD9_uc002ehc.2_Missense_Mutation_p.N2476S|CHD9_uc002ehf.2_Missense_Mutation_p.N1589S|CHD9_uc010cbw.2_Missense_Mutation_p.N557S	NM_025134	NP_079410	Q3L8U1	CHD9_HUMAN	chromodomain helicase DNA binding protein 9	2491					cellular lipid metabolic process|chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleoplasm	ATP binding|DNA binding|helicase activity|protein binding			lung(2)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|kidney(1)	7		all_cancers(37;0.0212)				CCAGTTATTAATCTTAAAGAT	0.428		NaN											0	0	0	0.006122	0	19	54				
SLC13A5	284111	broad.mit.edu	37	17	6606437	6606437	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr17:6606437C>T	uc002gdj.2	-	5	656	c.568G>A	c.(568-570)GGC>AGC	p.G190S	SLC13A5_uc010vtf.1_Missense_Mutation_p.G190S|SLC13A5_uc010clq.2_Missense_Mutation_p.G147S|SLC13A5_uc002gdk.2_Missense_Mutation_p.G173S|SLC13A5_uc002gdl.1_Missense_Mutation_p.G172S	NM_177550	NP_808218	Q86YT5	S13A5_HUMAN	solute carrier family 13, member 5 isoform a	190						integral to membrane	citrate transmembrane transporter activity				0						AGAGTGGGGCCTTCAAAAATC	0.627		NaN											0	0	0	0.014758	0	5	56				
ACAP1	9744	broad.mit.edu	37	17	7253548	7253548	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr17:7253548C>G	uc002ggd.2	+	20	2270	c.2064C>G	c.(2062-2064)ATC>ATG	p.I688M	KCTD11_uc002gge.3_5'Flank	NM_014716	NP_055531	Q15027	ACAP1_HUMAN	centaurin beta1	688	Required for interaction with GULP1.|ANK 3.				intracellular signal transduction|lipid metabolic process|protein transport|regulation of ARF GTPase activity		ARF GTPase activator activity|phospholipase C activity|protein binding|zinc ion binding			breast(2)|large_intestine(1)	3						ACGCTGACATCGTCACCCTGT	0.672		NaN											0	0	0	0.016723	0	14	37				
MYO18A	399687	broad.mit.edu	37	17	27447754	27447754	+	Silent	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr17:27447754G>A	uc002hdt.1	-	7	1766	c.1608C>T	c.(1606-1608)TAC>TAT	p.Y536Y	MYO18A_uc010wbc.1_Silent_p.Y78Y|MYO18A_uc002hds.2_Silent_p.Y78Y|MYO18A_uc010csa.1_Silent_p.Y536Y|MYO18A_uc002hdu.1_Silent_p.Y536Y|MYO18A_uc010wbd.1_Silent_p.Y205Y	NM_078471	NP_510880	Q92614	MY18A_HUMAN	myosin 18A isoform a	536	Myosin head-like.				anti-apoptosis|DNA metabolic process	ER-Golgi intermediate compartment|myosin complex	ATP binding|DNA binding|DNA-dependent ATPase activity|identical protein binding|motor activity				0			Epithelial(11;4.97e-05)|BRCA - Breast invasive adenocarcinoma(11;0.000221)|all cancers(11;0.000234)|Colorectal(6;0.0102)|COAD - Colon adenocarcinoma(6;0.031)			CCAGGAGGGTGTACAGAGCCT	0.577		NaN											0	0	0	0.010729	0	9	59				
ABCC3	8714	broad.mit.edu	37	17	48755296	48755296	+	Silent	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr17:48755296C>T	uc002isl.2	+	24	3650	c.3570C>T	c.(3568-3570)ATC>ATT	p.I1190I	ABCC3_uc002isn.2_5'Flank	NM_003786	NP_003777	O15438	MRP3_HUMAN	ATP-binding cassette, sub-family C, member 3	1190	ABC transmembrane type-1 2.|Cytoplasmic (By similarity).				bile acid metabolic process	integral to plasma membrane|membrane fraction	ATP binding|bile acid-exporting ATPase activity|organic anion transmembrane transporter activity			skin(3)|central_nervous_system(1)	4			BRCA - Breast invasive adenocarcinoma(22;3.05e-09)		Glibenclamide(DB01016)	CCTACATCATCTCCAACCGGT	0.577		NaN											0	0	0	0.008871	0	21	149				
INSR	3643	broad.mit.edu	37	19	7117211	7117211	+	Silent	SNP	A	A	G			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr19:7117211A>G	uc002mgd.1	-	22	4114	c.4005T>C	c.(4003-4005)TGT>TGC	p.C1335C	INSR_uc002mge.1_Silent_p.C1323C	NM_000208	NP_000199	P06213	INSR_HUMAN	insulin receptor isoform Long precursor	1335	Cytoplasmic (Potential).				activation of MAPK activity|activation of protein kinase B activity|carbohydrate metabolic process|fibroblast growth factor receptor signaling pathway|G-protein coupled receptor protein signaling pathway|glucose homeostasis|heart morphogenesis|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of cell proliferation|positive regulation of developmental growth|positive regulation of DNA replication|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of glycolysis|positive regulation of MAPKKK cascade|positive regulation of mitosis|positive regulation of nitric oxide biosynthetic process|positive regulation of protein kinase B signaling cascade|positive regulation of protein phosphorylation|positive regulation of respiratory burst|protein autophosphorylation|protein heterotetramerization|regulation of embryonic development|regulation of transcription, DNA-dependent|transformation of host cell by virus	caveola|endosome membrane|insulin receptor complex|microsome	ATP binding|GTP binding|insulin binding|insulin receptor activity|insulin receptor substrate binding|insulin-like growth factor I binding|insulin-like growth factor II binding|insulin-like growth factor receptor binding|metal ion binding|phosphatidylinositol 3-kinase binding|PTB domain binding|receptor signaling protein tyrosine kinase activity|SH2 domain binding			ovary(4)|lung(3)|central_nervous_system(2)|large_intestine(1)|stomach(1)|skin(1)	12					Insulin Glargine recombinant(DB00047)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CCTCCCTCTGACAGTGCGAGG	0.597		NaN											0	0	0	0.027356	0	29	56				
FBN3	84467	broad.mit.edu	37	19	8188893	8188893	+	Splice_Site	SNP	C	C	G			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr19:8188893C>G	uc002mjf.2	-	22	2753	c.2732_splice	c.e22-1	p.D911_splice		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor							proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						AATCTCACATCTGCACGGGGG	0.617		NaN											0	0	0	0.004482	0	9	15				
CLIP3	25999	broad.mit.edu	37	19	36508845	36508845	+	Missense_Mutation	SNP	C	C	T	rs149100841		TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr19:36508845C>T	uc010eeq.1	-	9	1514	c.1232G>A	c.(1231-1233)CGT>CAT	p.R411H	uc002ocy.2_Intron|CLIP3_uc002ocz.1_Missense_Mutation_p.R411H	NM_015526	NP_056341	Q96DZ5	CLIP3_HUMAN	CAP-GLY domain containing linker protein 3	411					chaperone-mediated protein transport|fat cell differentiation|membrane biogenesis|negative regulation of microtubule polymerization|peptidyl-L-cysteine S-palmitoylation|positive regulation of apoptosis|positive regulation of endocytosis|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose transport|positive regulation of protein phosphorylation	early endosome membrane|Golgi stack|membrane raft|microsome|plasma membrane|recycling endosome membrane|trans-Golgi network membrane	ganglioside binding|microtubule binding			ovary(2)|pancreas(1)|skin(1)	4	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GGCCCCGTCACGCTGCTGCAA	0.612		NaN											0	0	0	0.020292	0	14	49				
ATP1A3	478	broad.mit.edu	37	19	42486133	42486133	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr19:42486133C>A	uc002osg.2	-	9	1273	c.1119G>T	c.(1117-1119)CAG>CAT	p.Q373H	ATP1A3_uc010xwf.1_Missense_Mutation_p.Q384H|ATP1A3_uc010xwg.1_Missense_Mutation_p.Q343H|ATP1A3_uc010xwh.1_Missense_Mutation_p.Q386H|ATP1A3_uc002osh.2_Missense_Mutation_p.Q373H	NM_152296	NP_689509	P13637	AT1A3_HUMAN	Na+/K+ -ATPase alpha 3 subunit	373	Cytoplasmic (Potential).				ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(1)|pancreas(1)	2						TCATGCGGTTCTGAGTGAGGG	0.468		NaN											1	0	0.000442599	0.006214	0.000456218	8	177				
C19orf41	126123	broad.mit.edu	37	19	50666025	50666025	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr19:50666025G>A	uc002prp.1	-	2	365	c.278C>T	c.(277-279)ACG>ATG	p.T93M		NM_152358	NP_689571	Q6UXV1	IZUM2_HUMAN	hypothetical protein LOC126123 precursor	93	Extracellular (Potential).					integral to membrane					0		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00364)|OV - Ovarian serous cystadenocarcinoma(262;0.0052)		TAAGTGCTGCGTTTGGTTCTT	0.567		NaN											0	0	0	0.010729	0	10	48				
SHANK1	50944	broad.mit.edu	37	19	51165497	51165497	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr19:51165497C>T	uc002psx.1	-	23	6230	c.6211G>A	c.(6211-6213)GGG>AGG	p.G2071R	SHANK1_uc002psw.1_Missense_Mutation_p.G1455R	NM_016148	NP_057232	Q9Y566	SHAN1_HUMAN	SH3 and multiple ankyrin repeat domains 1	2071					cytoskeletal anchoring at plasma membrane	cell junction|cytoplasm|dendrite|membrane fraction|postsynaptic density|postsynaptic membrane	ionotropic glutamate receptor binding			large_intestine(2)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(134;0.0199)		CGCGAGGCCCCTGACAAGGCT	0.692		NaN											0	0	0	0.004672	0	3	28				
BRSK1	84446	broad.mit.edu	37	19	55816954	55816954	+	Silent	SNP	G	G	C			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr19:55816954G>C	uc002qkg.2	+	16	2167	c.1890G>C	c.(1888-1890)TCG>TCC	p.S630S	BRSK1_uc002qkf.2_Silent_p.S646S|BRSK1_uc002qkh.2_Silent_p.S325S	NM_032430	NP_115806	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	630					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|stomach(1)|lung(1)|breast(1)|skin(1)	6		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		CCTTTCTGTCGGTGAGGGGCC	0.557		NaN											0	0	0	0.01441	0	55	162				
ROCK2	9475	broad.mit.edu	37	2	11367412	11367412	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr2:11367412G>A	uc002rbd.1	-	6	1285	c.836C>T	c.(835-837)TCT>TTT	p.S279F		NM_004850	NP_004841	O75116	ROCK2_HUMAN	Rho-associated, coiled-coil containing protein	279	Protein kinase.				axon guidance|cytokinesis|intracellular signal transduction	cytosol|plasma membrane	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|structural molecule activity			stomach(2)|skin(2)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.137)|OV - Ovarian serous cystadenocarcinoma(76;0.162)		AACACCTACAGACCACCAATC	0.363		NaN											0	0	0	0.01441	0	53	113				
ADD2	119	broad.mit.edu	37	2	70903954	70903954	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr2:70903954C>T	uc002sgz.2	-	13	2032	c.1567G>A	c.(1567-1569)GTC>ATC	p.V523I	ADD2_uc010fds.1_RNA|ADD2_uc002sgy.2_Missense_Mutation_p.V523I|ADD2_uc002sha.2_Missense_Mutation_p.V217I|ADD2_uc002sgx.2_Missense_Mutation_p.V523I|ADD2_uc010fdt.1_Missense_Mutation_p.V523I|ADD2_uc002shc.1_Missense_Mutation_p.V523I|ADD2_uc002shd.1_Missense_Mutation_p.V217I|ADD2_uc010fdu.1_Missense_Mutation_p.V539I	NM_001617	NP_001608	P35612	ADDB_HUMAN	adducin 2 isoform a	523					actin filament bundle assembly|barbed-end actin filament capping|positive regulation of protein binding	cytoplasm|F-actin capping protein complex|plasma membrane	actin filament binding|calmodulin binding|metal ion binding|protein heterodimerization activity|protein homodimerization activity|spectrin binding			ovary(2)|pancreas(1)	3						TCGGCAATGACGCTCGCCAGG	0.602		NaN											0	0	0	0.013537	0	12	53				
RGPD4	285190	broad.mit.edu	37	2	108488251	108488251	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr2:108488251G>A	uc010ywk.1	+	20	3873	c.3791G>A	c.(3790-3792)AGT>AAT	p.S1264N	RGPD4_uc002tdu.2_Missense_Mutation_p.S451N|RGPD4_uc010ywl.1_Intron	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1264					intracellular transport		binding			skin(2)	2						GATAGTGTCAGTAGTAGCTCA	0.403		NaN											0	0	0	0.01441	0	122	253				
INHBB	3625	broad.mit.edu	37	2	121107201	121107201	+	Silent	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr2:121107201C>T	uc002tmn.2	+	2	1021	c.975C>T	c.(973-975)ACC>ACT	p.T325T		NM_002193	NP_002184	P09529	INHBB_HUMAN	inhibin beta B subunit preproprotein	325					activin receptor signaling pathway|cellular response to insulin stimulus|cellular response to starvation|defense response|fat cell differentiation|growth|negative regulation of follicle-stimulating hormone secretion|negative regulation of hepatocyte growth factor biosynthetic process|negative regulation of insulin secretion|ovarian follicle development|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation	extracellular region|perinuclear region of cytoplasm	cytokine activity|growth factor activity|hormone activity|host cell surface receptor binding|protein homodimerization activity			pancreas(2)|skin(1)	3		Prostate(154;0.122)				TAGCACCCACCGGCTACTACG	0.617		NaN											0	0	0	0.024334	0	26	74				
XIRP2	129446	broad.mit.edu	37	2	168107280	168107280	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr2:168107280A>G	uc002udx.2	+	8	9396	c.9378A>G	c.(9376-9378)ATA>ATG	p.I3126M	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.I2951M|XIRP2_uc010fpq.2_Missense_Mutation_p.I2904M|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	2951					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						TTATCACAATAGAATCTACTG	0.443		NaN											0	0	0	0.00499	0	18	86				
LRP2	4036	broad.mit.edu	37	2	170011072	170011072	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr2:170011072G>A	uc002ues.2	-	66	12406	c.12193C>T	c.(12193-12195)CGA>TGA	p.R4065*		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	4065	Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	TTATATTTTCGAATTCGGACA	0.378		NaN											0	0	0	0.027356	0	29	58				
TTN	7273	broad.mit.edu	37	2	179532370	179532370	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr2:179532370G>A	uc010zfk.1	-	6	694	c.146C>T	c.(145-147)GCA>GTA	p.A49V	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron|TTN_uc010fre.1_Intron			Q8WZ42	TITIN_HUMAN	SubName: Full=Titin; Flags: Fragment;	11243							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TATACCTTTTGCTAGTTTGGG	0.294		NaN											0	0	0	0.010504	0	18	104				
TTN	7273	broad.mit.edu	37	2	179640412	179640412	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr2:179640412G>A	uc010zfg.1	-	28	6403	c.6179C>T	c.(6178-6180)ACG>ATG	p.T2060M	TTN_uc010zfh.1_Missense_Mutation_p.T2014M|TTN_uc010zfi.1_Missense_Mutation_p.T2014M|TTN_uc010zfj.1_Missense_Mutation_p.T2014M|TTN_uc002unb.2_Missense_Mutation_p.T2060M|uc002unc.1_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2060							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTTGGAATCGTGATTTTGCC	0.423		NaN											0	0	0	0.028581	0	17	110				
DNER	92737	broad.mit.edu	37	2	230450646	230450646	+	Missense_Mutation	SNP	T	T	A	rs72987941	byFrequency	TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr2:230450646T>A	uc002vpv.2	-	4	922	c.775A>T	c.(775-777)ACC>TCC	p.T259S	DNER_uc010zly.1_5'UTR	NM_139072	NP_620711	Q8NFT8	DNER_HUMAN	delta-notch-like EGF repeat-containing	259	Extracellular (Potential).				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity	p.T259P(1)		lung(5)|ovary(2)|skin(1)	8		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		TGAAGGGGGGTCACACTTCGT	0.517		NaN											0	0	0	0.009096	0	4	59				
UGT1A10	54575	broad.mit.edu	37	2	234545237	234545237	+	Silent	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr2:234545237C>T	uc002vur.2	+	1	115	c.69C>T	c.(67-69)GCC>GCT	p.A23A	UGT1A8_uc010zmv.1_Intron|UGT1A8_uc002vup.2_Intron|UGT1A10_uc002vuq.3_Silent_p.A23A	NM_019075	NP_061948	Q9HAW8	UD110_HUMAN	UDP glycosyltransferase 1 family, polypeptide	23				MARAGWTSPVPLCVCLLLTCGFA -> MAPRRVDQPRSFMC VSTADLWLC (in Ref. 1).	flavone metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding			ovary(2)|skin(1)	3		Breast(86;0.000766)|all_lung(227;0.00271)|Renal(207;0.00339)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0334)|Lung NSC(271;0.0461)|Lung SC(224;0.128)		Epithelial(121;1.96e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000468)|Lung(119;0.00381)|LUSC - Lung squamous cell carcinoma(224;0.008)		GTGGCTTTGCCGAGGCAGGGA	0.597		NaN											0	0	0	0.021523	0	26	89				
MYH7B	57644	broad.mit.edu	37	20	33572681	33572681	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr20:33572681G>C	uc002xbi.1	+	10	891	c.799G>C	c.(799-801)GAG>CAG	p.E267Q		NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	myosin, heavy polypeptide 7B, cardiac muscle,	225	Myosin head-like.					membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)			TCAAATCATCGAGGCCAACCC	0.647		NaN											0	0	0	0.028581	0	15	50				
COL6A2	1292	broad.mit.edu	37	21	47531966	47531966	+	Silent	SNP	G	G	C	rs143583433	by1000genomes	TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr21:47531966G>C	uc002zia.1	+	3	271	c.189G>C	c.(187-189)ACG>ACC	p.T63T	COL6A2_uc002zhy.1_Silent_p.T63T|COL6A2_uc002zhz.1_Silent_p.T63T|COL6A2_uc002zib.1_Intron	NM_001849	NP_001840	P12110	CO6A2_HUMAN	alpha 2 type VI collagen isoform 2C2 precursor	63	VWFA 1.|Nonhelical region.				axon guidance|cell-cell adhesion|extracellular matrix organization|protein heterotrimerization	collagen|extracellular space|protein complex	extracellular matrix structural constituent|protein binding, bridging			central_nervous_system(7)|ovary(1)	8	Breast(49;0.245)			Colorectal(79;0.0303)|READ - Rectum adenocarcinoma(84;0.0649)		AGTCCCCCACGGACATCCTGC	0.612		NaN											0	0	0	0.01892	0	25	55				
BCL2L13	23786	broad.mit.edu	37	22	18210180	18210180	+	Silent	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr22:18210180C>T	uc002zmw.2	+	7	1556	c.1338C>T	c.(1336-1338)GCC>GCT	p.A446A	BCL2L13_uc002zmx.2_Silent_p.A284A|BCL2L13_uc002zmy.2_3'UTR|BCL2L13_uc010gqy.2_Silent_p.A284A|BCL2L13_uc011agk.1_Silent_p.A322A|BCL2L13_uc010gqz.2_Silent_p.A166A|BCL2L13_uc002zmz.2_Silent_p.A284A|BCL2L13_uc002zna.2_Silent_p.A166A	NM_015367	NP_056182	Q9BXK5	B2L13_HUMAN	BCL2-like 13 (apoptosis facilitator)	446	B; approximate.				induction of apoptosis	integral to membrane|mitochondrial membrane|nucleus	caspase activator activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4		all_epithelial(15;0.123)		Lung(27;0.199)		TGTCCCCCGCCGGTGAGATGA	0.612		NaN											0	0	0	0.012319	0	23	79				
EFCAB6	64800	broad.mit.edu	37	22	43930620	43930620	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr22:43930620G>C	uc003bdy.1	-	30	4396	c.4181C>G	c.(4180-4182)GCA>GGA	p.A1394G	EFCAB6_uc003bdz.1_Missense_Mutation_p.A1242G|EFCAB6_uc010gzi.1_Missense_Mutation_p.A1242G	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	1394	EF-hand 15.|Interaction with PARK7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				GCTTTCCTTTGCTTTTAGCAG	0.473		NaN											0	0	0	0.009096	0	4	53				
CELSR1	9620	broad.mit.edu	37	22	46859620	46859620	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr22:46859620G>T	uc003bhw.1	-	2	4167	c.4167C>A	c.(4165-4167)TGC>TGA	p.C1389*		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1389	Extracellular (Potential).|EGF-like 2; calcium-binding.				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		AGTCCTCGAAGCACTCGCAGG	0.647		NaN											1	0	0.000602214	0.014758	0.000616006	5	10				
CELSR1	9620	broad.mit.edu	37	22	46859881	46859881	+	Silent	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr22:46859881G>A	uc003bhw.1	-	2	3906	c.3906C>T	c.(3904-3906)TTC>TTT	p.F1302F		NM_014246	NP_055061	Q9NYQ6	CELR1_HUMAN	cadherin EGF LAG seven-pass G-type receptor 1	1302	Extracellular (Potential).				central nervous system development|homophilic cell adhesion|neural tube closure|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein dimerization activity			lung(4)|breast(4)|pancreas(2)|skin(1)	11		Ovarian(80;0.00142)|Breast(42;0.00296)|all_neural(38;0.0416)|Colorectal(5;0.0766)		UCEC - Uterine corpus endometrioid carcinoma (28;0.00643)|BRCA - Breast invasive adenocarcinoma(115;0.171)		TGTTGTCGTCGAAGGGCAGCA	0.637		NaN											0	0	0	0.006214	0	10	36				
RTP3	83597	broad.mit.edu	37	3	46542025	46542025	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr3:46542025C>G	uc003cps.1	+	2	403	c.335C>G	c.(334-336)TCA>TGA	p.S112*		NM_031440	NP_113628	Q9BQQ7	RTP3_HUMAN	transmembrane protein 7	112	Cytoplasmic (Potential).				detection of chemical stimulus involved in sensory perception of bitter taste|protein targeting to membrane	cytoplasm|integral to membrane	protein binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;0.00114)|KIRC - Kidney renal clear cell carcinoma(197;0.0173)|Kidney(197;0.0204)		GAGAACATCTCAAGGATCCTG	0.458		NaN											0	0	0	0.021022	0	39	87				
DOCK3	1795	broad.mit.edu	37	3	51266209	51266209	+	Nonsense_Mutation	SNP	A	A	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr3:51266209A>T	uc011bds.1	+	18	1788	c.1765A>T	c.(1765-1767)AAA>TAA	p.K589*		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	589	DHR-1.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		GCGCAGCACCAAAGAGTCTTT	0.517		NaN											0	0	0	0.020292	0	14	43				
PARP14	54625	broad.mit.edu	37	3	122419588	122419588	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr3:122419588C>G	uc003efq.3	+	6	2246	c.2187C>G	c.(2185-2187)GAC>GAG	p.D729E	PARP14_uc010hrk.2_RNA|PARP14_uc003efr.2_Missense_Mutation_p.D446E|PARP14_uc003efs.1_Missense_Mutation_p.D446E	NM_017554	NP_060024	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	729					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			ovary(2)|breast(2)|lung(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(114;0.0531)		AGGCAGTGGACATTGTCAAGC	0.408		NaN											0	0	0	0.004672	0	3	22				
MCM2	4171	broad.mit.edu	37	3	127325534	127325534	+	Silent	SNP	C	C	G			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr3:127325534C>G	uc003ejp.2	+	6	1032	c.975C>G	c.(973-975)GTC>GTG	p.V325V	MCM2_uc011bkm.1_Silent_p.V195V|MCM2_uc010hsl.2_RNA|MCM2_uc011bkn.1_Silent_p.V209V	NM_004526	NP_004517	P49736	MCM2_HUMAN	minichromosome maintenance complex component 2	325					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|helicase activity|metal ion binding			ovary(3)|skin(1)	4						TCAGCATGGTCAAGTACAACT	0.612		NaN											0	0	0	0.01892	0	26	79				
CLSTN2	64084	broad.mit.edu	37	3	140140011	140140011	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr3:140140011C>T	uc003etn.2	+	5	872	c.682C>T	c.(682-684)CAG>TAG	p.Q228*	CLSTN2_uc003etm.2_Nonsense_Mutation_p.Q228*	NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	228	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						CAAACAACACCAGTATGAGAT	0.502		NaN								HNSCC(16;0.037)			0	0	0	0.012213	0	34	97				
CLSTN2	64084	broad.mit.edu	37	3	140282913	140282913	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr3:140282913G>A	uc003etn.2	+	16	2783	c.2593G>A	c.(2593-2595)GAG>AAG	p.E865K		NM_022131	NP_071414	Q9H4D0	CSTN2_HUMAN	calsyntenin 2 precursor	865	Cytoplasmic (Potential).				homophilic cell adhesion	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|plasma membrane	calcium ion binding			skin(3)|large_intestine(2)|pancreas(1)|central_nervous_system(1)	7						CTTCATCCAGGAGACTGAGGC	0.562		NaN								HNSCC(16;0.037)			0	0	0	0.027356	0	27	125				
FAM131A	131408	broad.mit.edu	37	3	184062488	184062488	+	Silent	SNP	C	C	T	rs150189351	byFrequency	TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr3:184062488C>T	uc003fog.2	+	3	2102	c.738C>T	c.(736-738)GGC>GGT	p.G246G	FAM131A_uc003fob.1_Silent_p.G154G|FAM131A_uc003foc.2_Silent_p.G192G|FAM131A_uc003foe.2_Silent_p.G192G	NM_144635	NP_653236	Q6UXB0	F131A_HUMAN	hypothetical protein LOC131408 precursor	246						extracellular region				breast(1)	1	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			AGCTGCTGGGCGATGAGCTGC	0.667		NaN											0	0	0	0.006214	0	9	100				
ATP13A4	84239	broad.mit.edu	37	3	193130158	193130158	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr3:193130158G>A	uc003ftd.2	-	27	3125	c.3017C>T	c.(3016-3018)GCC>GTC	p.A1006V	ATP13A4_uc010hzi.2_RNA	NM_032279	NP_115655	Q4VNC1	AT134_HUMAN	ATPase type 13A4	1006	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(2)	2	all_cancers(143;1.76e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;2.72e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;0.000109)		TACTGTGCAGGCACTAAAAGG	0.398		NaN											0	0	0	0.023175	0	39	124				
UBA6	55236	broad.mit.edu	37	4	68514897	68514897	+	Silent	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr4:68514897G>A	uc003hdg.3	-	14	1189	c.1137C>T	c.(1135-1137)CTC>CTT	p.L379L	UBA6_uc003hdh.1_5'UTR	NM_018227	NP_060697	A0AVT1	UBA6_HUMAN	ubiquitin-activating enzyme E1-like 2	379					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding				0						CAGTCCAAGAGAGCCAATGCA	0.393		NaN											0	0	0	0.020292	0	13	65				
HSD17B13	345275	broad.mit.edu	37	4	88226451	88226451	+	Silent	SNP	A	A	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr4:88226451A>T	uc003hqo.2	-	7	885	c.822T>A	c.(820-822)CCT>CCA	p.P274P	HSD17B13_uc010ikk.2_Silent_p.P238P	NM_178135	NP_835236	Q7Z5P4	DHB13_HUMAN	hydroxysteroid (17-beta) dehydrogenase 13	274						extracellular region	binding|oxidoreductase activity				0		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.000308)		AGGCGCGTTCAGGAAGAAACC	0.333		NaN											0	0	0	0.00308	0	8	24				
FAT4	79633	broad.mit.edu	37	4	126238269	126238269	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr4:126238269C>T	uc003ifj.3	+	1	703	c.703C>T	c.(703-705)CAG>TAG	p.Q235*		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	235	Cadherin 2.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GGGCTACCTTCAGGTAAACGT	0.597		NaN									OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.010729	0	12	36				
FAT4	79633	broad.mit.edu	37	4	126239451	126239451	+	Silent	SNP	C	C	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr4:126239451C>A	uc003ifj.3	+	1	1885	c.1885C>A	c.(1885-1887)CGG>AGG	p.R629R		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	629	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						AGAGACTGACCGGAGGTCCTT	0.557		NaN											1	0	1.67942e-08	0.006122	1.78605e-08	18	51				
ELF2	1998	broad.mit.edu	37	4	139980487	139980487	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr4:139980487G>C	uc003ihp.1	-	9	1602	c.1396C>G	c.(1396-1398)CTG>GTG	p.L466V	ELF2_uc003ihm.1_Missense_Mutation_p.L418V|ELF2_uc003ihn.1_Missense_Mutation_p.L406V|ELF2_uc003iho.1_Missense_Mutation_p.L389V|ELF2_uc011chc.1_Missense_Mutation_p.L281V	NM_201999	NP_973728	Q15723	ELF2_HUMAN	E74-like factor 2 (ets domain transcription	478					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sequence-specific DNA binding transcription factor activity			ovary(1)|skin(1)	2	all_hematologic(180;0.162)					GATCCAGTCAGATTTGACTTT	0.443		NaN											0	0	0	0.00499	0	18	72				
DDX60L	91351	broad.mit.edu	37	4	169344916	169344916	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr4:169344916G>A	uc003irq.3	-	15	2161	c.1940C>T	c.(1939-1941)TCG>TTG	p.S647L	DDX60L_uc003irr.1_Missense_Mutation_p.S647L|DDX60L_uc003irs.1_Missense_Mutation_p.S374L	NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	647							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		TAAATCTTTCGAAATTTTGCC	0.308		NaN											0	0	0	0.004672	0	3	9				
EMB	133418	broad.mit.edu	37	5	49699204	49699204	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr5:49699204C>T	uc003jom.2	-	6	934	c.685G>A	c.(685-687)GAG>AAG	p.E229K	EMB_uc010ivq.2_Missense_Mutation_p.E23K|EMB_uc003jol.2_Missense_Mutation_p.E160K|EMB_uc011cpy.1_Missense_Mutation_p.E179K|EMB_uc010ivr.2_Missense_Mutation_p.E175K	NM_198449	NP_940851	Q6PCB8	EMB_HUMAN	embigin precursor	229	Extracellular (Potential).|Ig-like V-type 2.					integral to membrane					0	Lung SC(58;0.218)	Lung NSC(810;0.0795)				CCATCTTCCTCCAAAAGTTGT	0.418		NaN											0	0	0	0.016723	0	13	57				
IL31RA	133396	broad.mit.edu	37	5	55212787	55212787	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr5:55212787C>T	uc003jql.2	+	15	2199	c.2134C>T	c.(2134-2136)CGC>TGC	p.R712C	IL31RA_uc003jqm.2_Intron|IL31RA_uc003jqn.2_Intron|IL31RA_uc003jqo.2_Missense_Mutation_p.R570C	NM_139017	NP_620586	Q8NI17	IL31R_HUMAN	gp130-like monocyte receptor	680	Cytoplasmic (Potential).				anti-apoptosis|defense response|homeostatic process|JAK-STAT cascade|macrophage differentiation|MAPKKK cascade|monocyte differentiation|negative regulation of macrophage activation|positive regulation of cell proliferation|positive regulation of transcription, DNA-dependent|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|transmembrane receptor protein tyrosine kinase signaling pathway	integral to membrane|plasma membrane	cytokine receptor activity|protein kinase binding|transcription coactivator activity			ovary(1)	1		Lung NSC(810;6.93e-05)|Prostate(74;0.00741)|Breast(144;0.0544)|Ovarian(174;0.223)				AGAGGGGACCCGCCCAGAAGC	0.483		NaN											0	0	0	0.008291	0	11	49				
THBS4	7060	broad.mit.edu	37	5	79375841	79375841	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr5:79375841G>A	uc003kgh.2	+	21	2948	c.2625G>A	c.(2623-2625)TGG>TGA	p.W875*	uc003kgi.3_Intron	NM_003248	NP_003239	P35443	TSP4_HUMAN	thrombospondin 4 precursor	875	TSP C-terminal.				endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity				0		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		ATGTGGGCTGGAAGGACAAGG	0.597		NaN											0	0	0	0.006214	0	9	34				
RASA1	5921	broad.mit.edu	37	5	86679590	86679590	+	Silent	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr5:86679590C>T	uc003kiw.2	+	21	2869	c.2751C>T	c.(2749-2751)ATC>ATT	p.I917I	RASA1_uc010jav.2_RNA|RASA1_uc003kix.2_Silent_p.I740I|RASA1_uc011ctv.1_Silent_p.I750I|RASA1_uc011ctw.1_Silent_p.I751I|RASA1_uc010jaw.2_Silent_p.I739I	NM_002890	NP_002881	P20936	RASA1_HUMAN	RAS p21 protein activator 1 isoform 1	917	Ras-GAP.				cytokinesis|embryo development|intracellular signal transduction|negative regulation of cell-matrix adhesion|negative regulation of neuron apoptosis|negative regulation of Ras protein signal transduction|positive regulation of anti-apoptosis|regulation of actin filament polymerization|regulation of cell shape|regulation of RNA metabolic process|vasculogenesis	cytosol|intrinsic to internal side of plasma membrane	glycoprotein binding|GTPase binding|potassium channel inhibitor activity|Ras GTPase activator activity|receptor binding			upper_aerodigestive_tract(3)|ovary(1)|lung(1)	5		all_cancers(142;8.25e-07)|Lung NSC(167;0.000185)|all_lung(232;0.000222)|Colorectal(57;0.00542)|Ovarian(174;0.0423)		OV - Ovarian serous cystadenocarcinoma(54;4.72e-41)|Epithelial(54;1.51e-36)|all cancers(79;3.76e-31)		TGTTCAATATCATCTCAGGTA	0.274		NaN											0	0	0	0.021553	0	5	20				
PCDHA13	56136	broad.mit.edu	37	5	140263361	140263361	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr5:140263361C>A	uc003lif.2	+	1	1508	c.1508C>A	c.(1507-1509)GCG>GAG	p.A503E	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.A503E|PCDHA13_uc003lid.2_Missense_Mutation_p.A503E	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	503	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGCGAGCGTGCGCTGTCGAGC	0.672		NaN											1	0	0.000132079	0.008871	0.000137198	19	65				
ZNF354B	117608	broad.mit.edu	37	5	178310335	178310335	+	Silent	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr5:178310335G>A	uc003mjl.2	+	5	1108	c.882G>A	c.(880-882)GTG>GTA	p.V294V	ZNF354B_uc003mjm.2_Silent_p.V294V	NM_058230	NP_478137	Q96LW1	Z354B_HUMAN	zinc finger protein 354B	294					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCCATACTGTGGAGAAATGCT	0.378		NaN											0	0	0	0.009535	0	31	81				
ADAMTS2	9509	broad.mit.edu	37	5	178579179	178579179	+	Silent	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr5:178579179C>T	uc003mjw.2	-	10	1593	c.1593G>A	c.(1591-1593)GGG>GGA	p.G531G	ADAMTS2_uc011dgm.1_Silent_p.G531G	NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	531	Disintegrin.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CCAAGGGGGGCCCCTTCTTGG	0.592		NaN											0	0	0	0.021553	0	6	36				
OR2J2	26707	broad.mit.edu	37	6	29141694	29141694	+	Silent	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr6:29141694G>A	uc011dlm.1	+	1	384	c.282G>A	c.(280-282)TCG>TCA	p.S94S		NM_030905	NP_112167	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J,	94	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AGACCATCTCGTATGCTGGTT	0.473		NaN											0	0	0	0.006214	0	9	184				
ENPP1	5167	broad.mit.edu	37	6	132204911	132204911	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr6:132204911C>G	uc011ecf.1	+	22	2328	c.2308C>G	c.(2308-2310)CAA>GAA	p.Q770E		NM_006208	NP_006199	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	770	Nuclease.|Extracellular (Potential).				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			upper_aerodigestive_tract(2)|ovary(2)	4	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	CCAGAGTTTTCAAGGTAAATA	0.274		NaN											0	0	0	0.010504	0	21	44				
VWC2	375567	broad.mit.edu	37	7	49951714	49951714	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr7:49951714A>T	uc003tot.1	+	4	1467	c.911A>T	c.(910-912)TAT>TTT	p.Y304F		NM_198570	NP_940972	Q2TAL6	VWC2_HUMAN	von Willebrand factor C domain containing 2	304					negative regulation of BMP signaling pathway|positive regulation of neuron differentiation	basement membrane|extracellular space					0						CACTGTACTTATGAGGAAGGC	0.493		NaN											0	0	0	0.024245	0	14	40				
ZCWPW1	55063	broad.mit.edu	37	7	100013666	100013666	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr7:100013666C>T	uc003uut.2	-	8	931	c.683G>A	c.(682-684)CGA>CAA	p.R228Q	ZCWPW1_uc011kjq.1_Missense_Mutation_p.R108Q|ZCWPW1_uc003uur.2_Missense_Mutation_p.R108Q|ZCWPW1_uc003uus.2_Missense_Mutation_p.R108Q|ZCWPW1_uc011kjr.1_Missense_Mutation_p.R228Q|ZCWPW1_uc003uuu.1_Missense_Mutation_p.R228Q|ZCWPW1_uc011kjs.1_Missense_Mutation_p.R108Q	NM_017984	NP_060454	Q9H0M4	ZCPW1_HUMAN	zinc finger, CW type with PWWP domain 1	228							zinc ion binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TTTCTTTAGTCGGTCTTCCTG	0.443		NaN											0	0	0	0.008291	0	11	130				
CSMD1	64478	broad.mit.edu	37	8	2876065	2876065	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr8:2876065C>T	uc011kwk.1	-	52	8356	c.7966G>A	c.(7966-7968)GTG>ATG	p.V2656M	CSMD1_uc011kwj.1_Missense_Mutation_p.V1985M|CSMD1_uc010lrg.2_Intron	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	2656	Extracellular (Potential).|Sushi 17.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TGAGACCCCACAAGCGTGTAG	0.498		NaN											0	0	0	0.01441	0	69	108				
ADAM2	2515	broad.mit.edu	37	8	39604116	39604116	+	Missense_Mutation	SNP	T	T	A	rs142592344	byFrequency	TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr8:39604116T>A	uc003xnj.2	-	19	2124	c.2049A>T	c.(2047-2049)AAA>AAT	p.K683N	ADAM2_uc003xnk.2_Missense_Mutation_p.K664N|ADAM2_uc011lck.1_Missense_Mutation_p.K620N|ADAM2_uc003xnl.2_Missense_Mutation_p.K527N	NM_001464	NP_001455	Q99965	ADAM2_HUMAN	ADAM metallopeptidase domain 2 proprotein	683	Extracellular (Potential).				cell adhesion|fusion of sperm to egg plasma membrane|proteolysis	integral to plasma membrane	integrin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2		all_cancers(7;2.38e-28)|all_epithelial(6;8.85e-21)|all_lung(54;1.24e-07)|Lung NSC(58;1.94e-07)|Hepatocellular(245;0.00745)|Breast(189;0.00908)|Renal(179;0.0183)|Colorectal(162;0.246)	LUSC - Lung squamous cell carcinoma(45;0.000149)	READ - Rectum adenocarcinoma(644;0.0689)|Kidney(114;0.162)		ATCTCATTGGTTTGGAATGGT	0.299		NaN											0	0	0	0.01892	0	23	113				
DPY19L4	286148	broad.mit.edu	37	8	95751649	95751649	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr8:95751649G>A	uc003ygx.2	+	5	476	c.352G>A	c.(352-354)GAA>AAA	p.E118K	DPY19L4_uc003ygy.2_Missense_Mutation_p.E55K	NM_181787	NP_861452	Q7Z388	D19L4_HUMAN	dpy-19-like 4	118						integral to membrane				ovary(2)	2	Breast(36;3.85e-06)					AGGTGTTTACGAACTGACACA	0.313		NaN											0	0	0	0.00308	0	7	103				
PDCL	5082	broad.mit.edu	37	9	125585294	125585294	+	Splice_Site	SNP	C	C	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr9:125585294C>A	uc004bmz.1	-	3	450	c.354_splice	c.e3+1	p.K118_splice	PDCL_uc004bna.2_Splice_Site_p.K118_splice	NM_005388	NP_005379	Q13371	PHLP_HUMAN	phosducin-like						signal transduction|visual perception						0						CTGCTAATTACCTTCCCACTG	0.478		NaN											1	0	3.54561e-26	0.009718	3.92654e-26	42	60				
FAM48B2	170067	broad.mit.edu	37	X	24329557	24329557	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chrX:24329557C>T	uc011mjw.1	-	1	1876	c.1876G>A	c.(1876-1878)GGT>AGT	p.G626S		NM_001136233	NP_001129705	P0C7V6	F48B2_HUMAN	family with sequence similarity 48, member B2	626											0						TGCACTGCACCGGGCCTTGCA	0.622		NaN											0	0	0	0.009096	0	4	31				
IL2RG	3561	broad.mit.edu	37	X	70331384	70331384	+	Silent	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chrX:70331384C>T	uc004dyw.1	-	1	20	c.6G>A	c.(4-6)TTG>TTA	p.L2L	IL2RG_uc004dyv.1_5'Flank|IL2RG_uc004dyx.1_5'UTR	NM_000206	NP_000197	P31785	IL2RG_HUMAN	interleukin 2 receptor, gamma precursor	2					immune response|interleukin-4-mediated signaling pathway|interspecies interaction between organisms	external side of plasma membrane|integral to plasma membrane	cytokine receptor activity|interleukin-2 binding			pancreas(1)	1	Renal(35;0.156)				Aldesleukin(DB00041)|Denileukin diftitox(DB00004)	ATGATGGCTTCAACATGGCGC	0.552		NaN							Severe_Combined_Immunodeficiency_X-linked				0	0	0	0.004482	0	9	18				
ATP7A	538	broad.mit.edu	37	X	77268496	77268496	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chrX:77268496C>T	uc004ecx.3	+	10	2453	c.2293C>T	c.(2293-2295)CTT>TTT	p.L765F		NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	765	Extracellular (Potential).				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						TTTGATTATTCTTCTAGTTGC	0.423		NaN											0	0	0	0.01441	0	59	61				
MAGEC3	139081	broad.mit.edu	37	X	140969332	140969332	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chrX:140969332G>A	uc011mwp.1	+	4	659	c.659G>A	c.(658-660)GGC>GAC	p.G220D		NM_138702	NP_619647	Q8TD91	MAGC3_HUMAN	melanoma antigen family C, 3 isoform 1	220	MAGE 1.									skin(2)|central_nervous_system(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					ACATACACGGGCTACTTTCCT	0.438		NaN											0	0	0	0.01441	0	56	47				
ELF3	1999	broad.mit.edu	37	1	201983027	201983028	+	Frame_Shift_Ins	INS	-	-	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08			-	A	-	-		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:201983027_201983028insA	uc001gxg.3	+	7	4068_4069	c.876_877insA	c.(874-879)CTCATGfs	p.L292fs	ELF3_uc001gxi.3_Frame_Shift_Ins_p.L292fs|ELF3_uc001gxh.3_Frame_Shift_Ins_p.L292fs	NM_004433	NP_004424	P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription	292_293	ETS.				epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0						ACGAGGGCCTCATGAAGTGGGA	0.574		NaN											NaN	NaN	NaN	NaN	NaN	7	20	---	Valid	---	---
MTR	4548	broad.mit.edu	37	1	237024474	237024474	+	Frame_Shift_Del	DEL	A	A	-			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr1:237024474delA	uc001hyi.3	+	20	2516	c.2093delA	c.(2092-2094)CAAfs	p.Q698fs	MTR_uc010pxw.1_Frame_Shift_Del_p.Q291fs|MTR_uc010pxx.1_Intron|MTR_uc010pxy.1_Frame_Shift_Del_p.Q552fs	NM_000254	NP_000245	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine	698	B12-binding N-terminal.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	AGGTTAAACCAAAAAAAATAT	0.279		NaN											NaN	NaN	NaN	NaN	NaN	7	132	---		---	---
ZWILCH	55055	broad.mit.edu	37	15	66820228	66820229	+	Frame_Shift_Ins	INS	-	-	A			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr15:66820228_66820229insA	uc002aqb.2	+	10	1193_1194	c.947_948insA	c.(946-948)ACAfs	p.T316fs	ZWILCH_uc010bhu.1_Frame_Shift_Ins_p.T202fs|ZWILCH_uc002aqa.2_Frame_Shift_Ins_p.T202fs|ZWILCH_uc010bhv.2_Frame_Shift_Ins_p.T202fs	NM_017975	NP_060445	Q9H900	ZWILC_HUMAN	Zwilch	316					cell division|mitotic cell cycle checkpoint|mitotic prometaphase	condensed chromosome kinetochore|cytosol	protein binding			ovary(1)	1						GGTGATTCTACAAAAAAAGACA	0.317		NaN											NaN	NaN	NaN	NaN	NaN	26	46	---		---	---
TMEM102	284114	broad.mit.edu	37	17	7340636	7340636	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr17:7340636delG	uc002ggx.1	+	3	1611	c.1338delG	c.(1336-1338)GAGfs	p.E446fs	FGF11_uc010vtw.1_Intron|TMEM102_uc002ggy.1_Frame_Shift_Del_p.E446fs|FGF11_uc010cmh.1_5'Flank|FGF11_uc010cmi.2_5'Flank|FGF11_uc002ggz.2_5'Flank	NM_178518	NP_848613	Q8N9M5	TM102_HUMAN	transmembrane protein 102	446	Cytoplasmic (Potential).				regulation of apoptosis|response to cytokine stimulus|signal transduction	cell surface|integral to membrane|intracellular	protein binding				0		Prostate(122;0.173)				GAGTGCTCGAGGCCGGGACGT	0.697		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---		---	---
SF3A1	10291	broad.mit.edu	37	22	30742328	30742330	+	In_Frame_Del	DEL	CTG	CTG	-	rs141985009	byFrequency	TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr22:30742328_30742330delCTG	uc003ahl.2	-	3	496_498	c.364_366delCAG	c.(364-366)CAGdel	p.Q122del		NM_005877	NP_005868	Q15459	SF3A1_HUMAN	splicing factor 3a, subunit 1, 120kDa isoform 1	122	Poly-Gln.				nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nucleoplasm|U2-type spliceosomal complex	protein binding|RNA binding			ovary(3)|large_intestine(1)|pancreas(1)	5						GCTGGGTGGTCTGCTGCTGCTGC	0.596		NaN											NaN	NaN	NaN	NaN	NaN	8	97	---		---	---
TCTA	6988	broad.mit.edu	37	3	49450045	49450047	+	In_Frame_Del	DEL	TAC	TAC	-			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr3:49450045_49450047delTAC	uc003cwv.3	+	1	407_409	c.186_188delTAC	c.(184-189)AATACA>AAA	p.62_63NT>K	RHOA_uc010hku.2_5'Flank|RHOA_uc003cwu.2_5'Flank	NM_022171	NP_071503	P57738	TCTA_HUMAN	T-cell leukemia translocation altered	62_63	Extracellular (Potential).					integral to membrane					0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		TCTACGGGAATACAGTGACCGGG	0.635		NaN											NaN	NaN	NaN	NaN	NaN	30	84	---		---	---
C9orf41	138199	broad.mit.edu	37	9	77642981	77642983	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr9:77642981_77642983delCTC	uc004ajq.2	-	1	328_330	c.175_177delGAG	c.(175-177)GAGdel	p.E59del	C9orf41_uc011lsi.1_RNA	NM_152420	NP_689633	Q8N4J0	CI041_HUMAN	hypothetical protein LOC138199	59										ovary(1)|skin(1)	2						GCTCAAGCCTCTCCTCCTCCTCC	0.547		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---		---	---
SPTAN1	6709	broad.mit.edu	37	9	131388682	131388682	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chr9:131388682delT	uc004bvl.3	+	48	6390	c.6277delT	c.(6277-6279)TTCfs	p.F2093fs	SPTAN1_uc004bvm.3_Frame_Shift_Del_p.F2098fs|SPTAN1_uc004bvn.3_Frame_Shift_Del_p.F2073fs|SPTAN1_uc010mye.1_5'UTR|SPTAN1_uc010myf.1_5'UTR	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	2093	Spectrin 22.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						GGAGGACCTCTTCCTGACCTT	0.582		NaN											NaN	NaN	NaN	NaN	NaN	38	90	---		---	---
STAG2	10735	broad.mit.edu	37	X	123227957	123227974	+	In_Frame_Del	DEL	ATGAGGGAATGGATTTTG	ATGAGGGAATGGATTTTG	-			TCGA-FD-A3SQ-01A-21D-A22Z-08	TCGA-FD-A3SQ-10A-01D-A22Z-08			ATGAGGGAATGGATTTTG	-	ATGAGGGAATGGATTTTG	ATGAGGGAATGGATTTTG		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	cdf17db0-bd6b-4ff7-a06b-3dc3f262ae4f	42025d7c-6875-430f-a4e3-0ef370339cc2	g.chrX:123227957_123227974delATGAGGGAATGGATTTTG	uc004etz.3	+	31	3896_3913	c.3557_3574delATGAGGGAATGGATTTTG	c.(3556-3576)AATGAGGGAATGGATTTTGAC>AAC	p.EGMDFD1187del	STAG2_uc004eua.2_In_Frame_Del_p.EGMDFD1224del|STAG2_uc004eub.2_In_Frame_Del_p.EGMDFD1187del|STAG2_uc004euc.2_In_Frame_Del_p.EGMDFD1224del|STAG2_uc004eud.2_In_Frame_Del_p.EGMDFD1187del|STAG2_uc004eue.2_In_Frame_Del_p.EGMDFD1187del	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	1187_1192					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						GAGGATCTTAATGAGGGAATGGATTTTGACACCATGGA	0.353		NaN											NaN	NaN	NaN	NaN	NaN	10	42	---	Valid	---	---
