Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_by_all_platform	validation_method	validation_tumor_sample
CCNL2	81669	broad.mit.edu	37	1	1325663	1325663	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:1325663C>T	uc001afi.2	-	8	985	c.953G>A	c.(952-954)GGG>GAG	p.G318E	CCNL2_uc010nym.1_RNA|CCNL2_uc001aff.1_Missense_Mutation_p.G96E|CCNL2_uc001afg.1_Missense_Mutation_p.G96E|CCNL2_uc001afh.2_3'UTR|CCNL2_uc001afj.2_3'UTR|CCNL2_uc001afk.2_3'UTR	NM_030937	NP_112199	Q96S94	CCNL2_HUMAN	cyclin L2 isoform A	318					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			ovary(2)|central_nervous_system(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.03e-36)|OV - Ovarian serous cystadenocarcinoma(86;4.17e-22)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.0023)|BRCA - Breast invasive adenocarcinoma(365;0.00465)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.146)		CTGTGTGCCCCCAGGCAACAG	0.572		NaN											0	0	0	1	0	22	119				
PLCH2	9651	broad.mit.edu	37	1	2435841	2435841	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:2435841C>G	uc001aji.1	+	22	3714	c.3440C>G	c.(3439-3441)TCC>TGC	p.S1147C	PLCH2_uc010nyz.1_3'UTR|PLCH2_uc009vle.1_Missense_Mutation_p.S899C|PLCH2_uc001ajj.1_3'UTR|PLCH2_uc001ajk.1_3'UTR|PLCH2_uc001ajl.1_5'UTR	NM_014638	NP_055453	O75038	PLCH2_HUMAN	phospholipase C, eta 2	1147					intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(3)|ovary(1)|skin(1)	5	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		TCCTCCTCCTCCAGCATGTCA	0.662		NaN											0	0	0	1	0	8	41				
MMEL1	79258	broad.mit.edu	37	1	2541195	2541195	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:2541195C>T	uc001ajy.2	-	5	582	c.368G>A	c.(367-369)TGG>TAG	p.W123*	MMEL1_uc009vlg.1_RNA	NM_033467	NP_258428	Q495T6	MMEL1_HUMAN	membrane metallo-endopeptidase-like 1	123	Lumenal (Potential).				proteolysis	extracellular region|integral to membrane|intracellular membrane-bounded organelle	metal ion binding|metalloendopeptidase activity				0	all_cancers(77;0.000233)|all_epithelial(69;8.55e-05)|all_lung(157;0.0228)|Lung NSC(156;0.0402)|Ovarian(185;0.0634)	all_epithelial(116;1.03e-20)|all_lung(118;5.15e-09)|Lung NSC(185;9.02e-07)|Breast(487;0.00147)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;4.31e-38)|OV - Ovarian serous cystadenocarcinoma(86;8.52e-23)|GBM - Glioblastoma multiforme(42;1.49e-08)|Colorectal(212;4.79e-05)|COAD - Colon adenocarcinoma(227;0.000213)|Kidney(185;0.000371)|BRCA - Breast invasive adenocarcinoma(365;0.00219)|KIRC - Kidney renal clear cell carcinoma(229;0.00571)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.131)		GCGCCGCAGCCAGCCTCCGCA	0.607		NaN											0	0	0	1	0	18	59				
KIAA0562	9731	broad.mit.edu	37	1	3756216	3756216	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:3756216C>G	uc001aky.2	-	7	1050	c.691G>C	c.(691-693)GAT>CAT	p.D231H	KIAA0562_uc010nzm.1_RNA|KIAA0562_uc001akz.2_Missense_Mutation_p.D231H	NM_014704	NP_055519	O60308	CE104_HUMAN	glycine-, glutamate-,	231	Potential.					centriole	binding				0	all_cancers(77;0.0395)|Ovarian(185;0.0634)|all_lung(157;0.222)|Lung NSC(156;0.227)	all_epithelial(116;3.96e-21)|all_lung(118;2.74e-08)|Lung NSC(185;6.4e-06)|Breast(487;0.00066)|Renal(390;0.00121)|Hepatocellular(190;0.00335)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.031)|Lung SC(97;0.0548)|Medulloblastoma(700;0.212)		Epithelial(90;6.85e-39)|OV - Ovarian serous cystadenocarcinoma(86;1.59e-22)|GBM - Glioblastoma multiforme(42;3.16e-16)|Colorectal(212;2.01e-05)|COAD - Colon adenocarcinoma(227;7.99e-05)|BRCA - Breast invasive adenocarcinoma(365;0.000389)|Kidney(185;0.000513)|STAD - Stomach adenocarcinoma(132;0.00709)|KIRC - Kidney renal clear cell carcinoma(229;0.00714)|Lung(427;0.137)		TTGGCATAATCATAGCGTTCC	0.358		NaN											0	0	0	1	0	84	39				
NOL9	79707	broad.mit.edu	37	1	6585981	6585981	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:6585981C>G	uc001ans.2	-	12	2061	c.2042G>C	c.(2041-2043)AGA>ACA	p.R681T	NOL9_uc010nzs.1_RNA	NM_024654	NP_078930	Q5SY16	NOL9_HUMAN	nucleolar protein 9	681					maturation of 5.8S rRNA	nucleolus	ATP binding|polynucleotide 5'-hydroxyl-kinase activity|RNA binding			skin(1)	1	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;2.46e-35)|all_epithelial(116;1.41e-22)|all_lung(118;7.59e-07)|Lung NSC(185;4.28e-06)|Colorectal(325;4.52e-05)|Breast(487;0.000353)|Renal(390;0.0007)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.47e-07)|COAD - Colon adenocarcinoma(227;1.47e-05)|Kidney(185;5.27e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000971)|BRCA - Breast invasive adenocarcinoma(365;0.00113)|STAD - Stomach adenocarcinoma(132;0.0017)|READ - Rectum adenocarcinoma(331;0.0649)		CTCAGGTTCTCTTGCTCCAAT	0.423		NaN											0	0	0	1	0	40	128				
PIK3CD	5293	broad.mit.edu	37	1	9782153	9782153	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:9782153G>C	uc001aqb.3	+	17	2384	c.2176G>C	c.(2176-2178)GAG>CAG	p.E726Q	PIK3CD_uc010oaf.1_Missense_Mutation_p.E725Q|PIK3CD_uc001aqe.3_Missense_Mutation_p.E750Q	NM_005026	NP_005017	O00329	PK3CD_HUMAN	catalytic phosphatidylinositol 3-kinase delta	726					phosphatidylinositol-mediated signaling|protein phosphorylation	phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(4)|skin(2)|central_nervous_system(1)	7	all_lung(157;0.222)	all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0231)|Colorectal(212;7.52e-08)|COAD - Colon adenocarcinoma(227;1.78e-05)|Kidney(185;0.000322)|KIRC - Kidney renal clear cell carcinoma(229;0.00114)|BRCA - Breast invasive adenocarcinoma(304;0.0021)|STAD - Stomach adenocarcinoma(132;0.00395)|READ - Rectum adenocarcinoma(331;0.0419)		GGCCTACCTAGAGGCCCTCTC	0.637		NaN									OREG0013082	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	15	39				
VPS13D	55187	broad.mit.edu	37	1	12364770	12364770	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:12364770G>C	uc001atv.2	+	26	6565	c.6424G>C	c.(6424-6426)GAG>CAG	p.E2142Q	VPS13D_uc001atw.2_Missense_Mutation_p.E2142Q|VPS13D_uc001atx.2_Missense_Mutation_p.E1330Q	NM_015378	NP_056193	Q5THJ4	VP13D_HUMAN	vacuolar protein sorting 13D isoform 1	2142					protein localization					ovary(4)|pancreas(1)	5	Ovarian(185;0.249)	Lung NSC(185;4.08e-05)|all_lung(284;4.55e-05)|Renal(390;0.000147)|Colorectal(325;0.00058)|Breast(348;0.00093)|Ovarian(437;0.00965)|Hepatocellular(190;0.0202)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0327)|Colorectal(212;4.63e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000289)|COAD - Colon adenocarcinoma(227;0.000801)|Kidney(185;0.00216)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(313;0.012)|READ - Rectum adenocarcinoma(331;0.0476)|Lung(427;0.209)		TGTTGGCCAAGAGTCCAGTAG	0.522		NaN											0	0	0	1	0	39	14				
SPEN	23013	broad.mit.edu	37	1	16260296	16260296	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:16260296G>A	uc001axk.1	+	11	7765	c.7561G>A	c.(7561-7563)GAC>AAC	p.D2521N	SPEN_uc010obp.1_Missense_Mutation_p.D2480N	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	2521	RID.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		TCTTCCCCCAGACACAAAGGC	0.562		NaN											0	0	0	1	0	70	205				
SPEN	23013	broad.mit.edu	37	1	16262749	16262749	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:16262749G>A	uc001axk.1	+	11	10218	c.10014G>A	c.(10012-10014)AAG>AAA	p.K3338K	SPEN_uc010obp.1_Silent_p.K3297K	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	3338	Pro-rich.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CCCGGACCAAGACAGCTGCTC	0.592		NaN											0	0	0	1	0	29	31				
NECAP2	55707	broad.mit.edu	37	1	16767292	16767292	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:16767292C>T	uc001ayo.2	+	1	126	c.36C>T	c.(34-36)GTC>GTT	p.V12V	NECAP2_uc001ayp.3_RNA|NECAP2_uc010ocd.1_Intron|NECAP2_uc001ayq.2_Silent_p.V12V	NM_018090	NP_060560	Q9NVZ3	NECP2_HUMAN	NECAP endocytosis associated 2 isoform 1	12					endocytosis|protein transport	clathrin vesicle coat|coated pit|plasma membrane					0		Colorectal(325;0.000147)|Renal(390;0.00145)|Lung NSC(340;0.00215)|Breast(348;0.00224)|all_lung(284;0.00351)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0646)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0182)|COAD - Colon adenocarcinoma(227;1.13e-05)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|Kidney(64;0.000181)|KIRC - Kidney renal clear cell carcinoma(64;0.00268)|STAD - Stomach adenocarcinoma(196;0.012)|READ - Rectum adenocarcinoma(331;0.0649)		TGCTCTGTGTCAAGCCTGACG	0.627		NaN									OREG0013136	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	11	49				
PADI6	353238	broad.mit.edu	37	1	17699682	17699682	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:17699682C>A	uc001bak.1	+	2	248	c.248C>A	c.(247-249)GCC>GAC	p.A83D		NM_207421	NP_997304	Q6TGC4	PADI6_HUMAN	peptidylarginine deiminase type 6	75					peptidyl-citrulline biosynthetic process from peptidyl-arginine	cytoplasm|nucleus	calcium ion binding|protein-arginine deiminase activity			breast(1)	1		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00488)|BRCA - Breast invasive adenocarcinoma(304;7.59e-06)|COAD - Colon adenocarcinoma(227;1.18e-05)|Kidney(64;0.000186)|KIRC - Kidney renal clear cell carcinoma(64;0.00272)|STAD - Stomach adenocarcinoma(196;0.0134)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.189)	L-Citrulline(DB00155)	CCCACGTACGCCACAGTGAAG	0.597		NaN											1	0	3.45872e-05	1	3.56746e-05	17	18				
ARHGEF10L	55160	broad.mit.edu	37	1	18021748	18021748	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:18021748C>T	uc001ban.2	+	28	3439	c.3280C>T	c.(3280-3282)CGG>TGG	p.R1094W	ARHGEF10L_uc001bao.2_Missense_Mutation_p.R1055W|ARHGEF10L_uc001bap.2_Missense_Mutation_p.R1050W|ARHGEF10L_uc001baq.2_Missense_Mutation_p.R855W|ARHGEF10L_uc010ocs.1_Missense_Mutation_p.R867W|ARHGEF10L_uc001bar.2_Missense_Mutation_p.R797W|ARHGEF10L_uc009vpf.2_RNA|ARHGEF10L_uc001bas.2_Missense_Mutation_p.R118W	NM_018125	NP_060595	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF)	1094					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|ovary(1)|pancreas(1)	3		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		GCCCGTGCCTCGGCTGGAAGG	0.647		NaN											0	0	0	1	0	13	49				
UBR4	23352	broad.mit.edu	37	1	19436596	19436596	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:19436596C>A	uc001bbi.2	-	81	12103	c.12099G>T	c.(12097-12099)AAG>AAT	p.K4033N		NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	4033					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		GTACCTTGTTCTTCTTGCTAG	0.542		NaN											1	0	1.61788e-16	1	1.78652e-16	31	87				
CELA3B	23436	broad.mit.edu	37	1	22303559	22303559	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:22303559C>T	uc001bfk.2	+	1	142	c.27C>T	c.(25-27)CTC>CTT	p.L9L	CELA3B_uc009vqf.2_Silent_p.L8L	NM_007352	NP_031378	P08861	CEL3B_HUMAN	elastase 3B, pancreatic preproprotein	9					cholesterol metabolic process|proteolysis	extracellular region	serine-type endopeptidase activity			ovary(1)	1						TCAGTTCCCTCCTCCTTGTGG	0.527		NaN											0	0	0	1	0	59	196				
ZBTB40	9923	broad.mit.edu	37	1	22852749	22852749	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:22852749G>C	uc001bft.2	+	19	4091	c.3580G>C	c.(3580-3582)GAG>CAG	p.E1194Q	ZBTB40_uc001bfu.2_Missense_Mutation_p.E1194Q|ZBTB40_uc009vqi.1_Missense_Mutation_p.E1082Q	NM_001083621	NP_001077090	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	1194					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		CACTTTGGAGGAGACCCAGCT	0.587		NaN											0	0	0	1	0	19	78				
MYOM3	127294	broad.mit.edu	37	1	24421367	24421367	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:24421367C>T	uc001bin.3	-	9	1067	c.904G>A	c.(904-906)GAG>AAG	p.E302K	MYOM3_uc001bim.3_5'UTR|MYOM3_uc001bio.2_Missense_Mutation_p.E302K|MYOM3_uc001bip.1_5'UTR	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	302	Ig-like C2-type 2.									skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		TGGATGCTCTCAGCATCTAAC	0.577		NaN											0	0	0	1	0	9	30				
LIN28A	79727	broad.mit.edu	37	1	26752886	26752886	+	Silent	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:26752886C>G	uc001bmj.2	+	4	681	c.567C>G	c.(565-567)ACC>ACG	p.T189T	LIN28A_uc001bmi.1_RNA	NM_024674	NP_078950	Q9H9Z2	LN28A_HUMAN	lin-28 homolog	189					miRNA catabolic process|pre-miRNA processing|regulation of transcription, DNA-dependent|RNA 3'-end processing|stem cell maintenance	cytoplasmic mRNA processing body|nucleolus|stress granule	DNA binding|zinc ion binding			central_nervous_system(1)	1						GAAAGCCAACCTACTTTCGAG	0.557		NaN											0	0	0	1	0	18	55				
PIGV	55650	broad.mit.edu	37	1	27121497	27121497	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:27121497G>C	uc001bmz.2	+	3	1303	c.972G>C	c.(970-972)CAG>CAC	p.Q324H	PIGV_uc001bmy.2_Missense_Mutation_p.Q89H|PIGV_uc009vso.2_Missense_Mutation_p.Q324H|PIGV_uc010ofg.1_Missense_Mutation_p.Q89H|PIGV_uc001bna.2_Missense_Mutation_p.Q324H	NM_017837	NP_060307	Q9NUD9	PIGV_HUMAN	phosphatidylinositol glycan class V	324	Lumenal (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	glycolipid mannosyltransferase activity			ovary(1)	1		all_cancers(24;3.93e-26)|all_epithelial(13;3.96e-23)|Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;7.26e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.26e-54)|Epithelial(14;2.85e-53)|OV - Ovarian serous cystadenocarcinoma(117;1.91e-30)|Colorectal(126;1.31e-09)|COAD - Colon adenocarcinoma(152;3.45e-07)|BRCA - Breast invasive adenocarcinoma(304;0.000504)|STAD - Stomach adenocarcinoma(196;0.000588)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|GBM - Glioblastoma multiforme(114;0.0222)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.153)|LUSC - Lung squamous cell carcinoma(448;0.227)		AGCTCAAGCAGGTGCCCAATT	0.488		NaN											0	0	0	1	0	45	202				
COL16A1	1307	broad.mit.edu	37	1	32140871	32140871	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:32140871G>A	uc001btk.1	-	43	3179	c.2814C>T	c.(2812-2814)CTC>CTT	p.L938L	COL16A1_uc001btj.1_Silent_p.L751L	NM_001856	NP_001847	Q07092	COGA1_HUMAN	alpha 1 type XVI collagen precursor	938	Triple-helical region 4 (COL4) with 2 imperfections.				cell adhesion|female pregnancy|integrin-mediated signaling pathway	collagen type XVI	integrin binding|structural molecule activity			ovary(8)	8		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0423)|all_neural(195;0.0837)|Breast(348;0.116)		STAD - Stomach adenocarcinoma(196;0.059)		GTTCTGCAGTGAGCCCAGGCT	0.617		NaN											0	0	0	1	0	11	15				
KIAA1522	57648	broad.mit.edu	37	1	33237530	33237530	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:33237530C>G	uc001bvv.2	+	6	2709	c.2573C>G	c.(2572-2574)TCA>TGA	p.S858*	KIAA1522_uc001bvu.1_Nonsense_Mutation_p.S917*|KIAA1522_uc010ohm.1_Nonsense_Mutation_p.S869*|KIAA1522_uc010ohn.1_Intron	NM_020888	NP_065939	Q9P206	K1522_HUMAN	hypothetical protein LOC57648	858	Pro-rich.										0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Breast(348;0.244)				AGGGCCCTGTCAGGGCGGGCC	0.706		NaN											0	0	0	1	0	4	14				
CSF3R	1441	broad.mit.edu	37	1	36932897	36932897	+	Silent	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:36932897G>T	uc001caw.1	-	16	2152	c.1974C>A	c.(1972-1974)CTC>CTA	p.L658L	MRPS15_uc001cas.2_5'Flank|CSF3R_uc001cat.1_Silent_p.L220L|CSF3R_uc009vvc.1_Silent_p.L187L|CSF3R_uc001cau.1_Silent_p.L58L|CSF3R_uc001cav.1_Silent_p.L658L|CSF3R_uc001cax.1_Silent_p.L658L|CSF3R_uc001cay.1_Missense_Mutation_p.S627Y	NM_000760	NP_000751	Q99062	CSF3R_HUMAN	colony stimulating factor 3 receptor isoform a	658	Box 1 motif.|Cytoplasmic (Potential).				cell adhesion|defense response	extracellular region|integral to plasma membrane	cytokine receptor activity			central_nervous_system(2)|ovary(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	CACTTGGCCAGAGGGGATTCT	0.587		NaN											1	0	2.47872e-24	1	2.78548e-24	38	35				
EPHA10	284656	broad.mit.edu	37	1	38192853	38192853	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:38192853C>T	uc009vvi.2	-	8	1779	c.1693G>A	c.(1693-1695)GCC>ACC	p.A565T	EPHA10_uc009vvh.1_RNA|EPHA10_uc001cbu.2_RNA|EPHA10_uc001cbv.1_RNA	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	565	Extracellular (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				ACGACAATGGCGGGGCTCTGG	0.642		NaN											0	0	0	1	0	7	22				
EPHA10	284656	broad.mit.edu	37	1	38227612	38227612	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:38227612C>T	uc009vvi.2	-	3	401	c.315G>A	c.(313-315)CTG>CTA	p.L105L	EPHA10_uc001cbw.3_Silent_p.L105L	NM_001099439	NP_001092909	Q5JZY3	EPHAA_HUMAN	EPH receptor A10 isofom 3	105	Extracellular (Potential).					extracellular region|integral to membrane|integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding|transmembrane-ephrin receptor activity			breast(4)|stomach(3)|lung(1)	8	Acute lymphoblastic leukemia(166;0.074)|all_hematologic(146;0.197)	Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GTGTGAACTGCAGTTCCACGA	0.617		NaN											0	0	0	1	0	71	57				
ZNF642	339559	broad.mit.edu	37	1	40961190	40961190	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:40961190G>A	uc001cfo.2	+	6	1334	c.1040G>A	c.(1039-1041)AGA>AAA	p.R347K	ZNF642_uc009vwb.2_Missense_Mutation_p.R347K|ZNF642_uc010ojk.1_Missense_Mutation_p.R348K	NM_198494	NP_940896	Q49AA0	ZN642_HUMAN	zinc finger protein 642	347	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;8.81e-19)			CAGCATCATAGAACTCACACT	0.433		NaN											0	0	0	1	0	25	71				
EBNA1BP2	10969	broad.mit.edu	37	1	43630326	43630326	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:43630326C>G	uc001cin.2	-	8	1055	c.858G>C	c.(856-858)AAG>AAC	p.K286N	EBNA1BP2_uc001cio.2_Missense_Mutation_p.K341N|EBNA1BP2_uc001cim.2_Missense_Mutation_p.K181N|EBNA1BP2_uc010ojx.1_Missense_Mutation_p.K341N	NM_006824	NP_006815	Q99848	EBP2_HUMAN	EBNA1 binding protein 2 isoform 2	286					ribosome biogenesis	membrane fraction|nucleolus	protein binding				0	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TTGACCCTTTCTTGCCAGGCC	0.572		NaN											0	0	0	1	0	33	20				
ARTN	9048	broad.mit.edu	37	1	44401357	44401357	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:44401357C>T	uc001cks.2	+	3	811	c.29C>T	c.(28-30)ACG>ATG	p.T10M	ARTN_uc001ckv.2_Missense_Mutation_p.T10M|ARTN_uc001ckt.2_Missense_Mutation_p.T10M|ARTN_uc001cku.2_Missense_Mutation_p.T10M|ARTN_uc001ckw.2_5'Flank	NM_057091	NP_476432	Q5T4W7	ARTN_HUMAN	neurotrophic factor artemin isoform 1 precursor	10					axon guidance|neuroblast proliferation|signal transduction	extracellular region	growth factor activity				0	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)				GGCCTCTCCACGCTGTCCCAC	0.597		NaN											0	0	0	1	0	7	13				
IPO13	9670	broad.mit.edu	37	1	44422329	44422329	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:44422329G>T	uc001ckx.2	+	4	1855	c.1060G>T	c.(1060-1062)GAG>TAG	p.E354*		NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	354	HEAT 5.				protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				TCCTGTCAATGAGACCACCAG	0.547		NaN											1	0	1.49673e-21	1	1.67272e-21	39	69				
IPO13	9670	broad.mit.edu	37	1	44424502	44424502	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:44424502G>A	uc001ckx.2	+	11	2764	c.1969G>A	c.(1969-1971)GAG>AAG	p.E657K		NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	657	HEAT 11.				protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				CAGTCATCATGAGGATGATCA	0.547		NaN											0	0	0	1	0	24	39				
STIL	6491	broad.mit.edu	37	1	47717130	47717130	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:47717130G>A	uc001crc.1	-	17	3697	c.3542C>T	c.(3541-3543)TCT>TTT	p.S1181F	TAL1_uc001crb.1_Intron|STIL_uc010omn.1_Missense_Mutation_p.S1135F|STIL_uc010omo.1_Missense_Mutation_p.S1164F|STIL_uc001crd.1_Missense_Mutation_p.S1182F|STIL_uc001cre.1_Missense_Mutation_p.S1181F	NM_003035	NP_003026	Q15468	STIL_HUMAN	SCL/TAL1 interrupting locus isoform 2	1181					cell proliferation|multicellular organismal development	centrosome|cytosol				lung(2)|skin(1)	3		Acute lymphoblastic leukemia(5;0.00116)|all_hematologic(5;0.00444)				TTCACAGTTAGAACAATTAAT	0.373		NaN											0	0	0	1	0	36	66				
FAF1	11124	broad.mit.edu	37	1	50956338	50956338	+	Splice_Site	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:50956338C>G	uc009vyx.1	-	18	1639	c.1576_splice	c.e18-1	p.R526_splice	FAF1_uc009vyw.1_Splice_Site|FAF1_uc001cse.1_Splice_Site_p.R526_splice|FAF1_uc010onc.1_Splice_Site_p.R284_splice	NM_007051	NP_008982	Q9UNN5	FAF1_HUMAN	FAS-associated factor 1						apoptosis|cytoplasmic sequestering of NF-kappaB|positive regulation of apoptosis|positive regulation of protein complex assembly|proteasomal ubiquitin-dependent protein catabolic process|regulation of protein catabolic process	CD95 death-inducing signaling complex|cytosol|perinuclear region of cytoplasm	heat shock protein binding|NF-kappaB binding|protein kinase binding|protein kinase regulator activity			ovary(1)|pancreas(1)	2				GBM - Glioblastoma multiforme(3;3.18e-11)|all cancers(3;0.00526)		GAGCTTCCCTCTGTTGATAAA	0.308		NaN											0	0	0	1	0	34	74				
C1orf168	199920	broad.mit.edu	37	1	57192183	57192183	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:57192183C>G	uc001cym.3	-	16	2273	c.1867G>C	c.(1867-1869)GAA>CAA	p.E623Q	C1orf168_uc009vzu.1_RNA|C1orf168_uc001cyl.2_RNA	NM_001004303	NP_001004303	Q5VWT5	CA168_HUMAN	hypothetical protein LOC199920	623										ovary(3)|skin(2)	5						TCTGATTCTTCAGCACCGTTT	0.299		NaN											0	0	0	1	0	20	67				
TACSTD2	4070	broad.mit.edu	37	1	59042168	59042168	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:59042168C>A	uc001cyz.3	-	1	999	c.661G>T	c.(661-663)GAT>TAT	p.D221Y		NM_002353	NP_002344	P09758	TACD2_HUMAN	tumor-associated calcium signal transducer 2	221	Extracellular (Potential).				cell proliferation|cell surface receptor linked signaling pathway|visual perception	cytosol|integral to plasma membrane	receptor activity				0	all_cancers(7;6.54e-05)					TAGGCGGCATCGCCGATATCC	0.652		NaN											1	0	8.12818e-05	1	8.34986e-05	7	14				
JAK1	3716	broad.mit.edu	37	1	65316594	65316594	+	Splice_Site	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:65316594C>T	uc001dbu.1	-	12	1898	c.1649_splice	c.e12-1	p.E550_splice	JAK1_uc009wam.1_Splice_Site_p.E538_splice	NM_002227	NP_002218	P23458	JAK1_HUMAN	janus kinase 1						interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to antibiotic|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|endomembrane system|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			haematopoietic_and_lymphoid_tissue(34)|prostate(7)|soft_tissue(6)|lung(4)|breast(3)|central_nervous_system(2)|liver(2)|large_intestine(1)|stomach(1)|ovary(1)	61				BRCA - Breast invasive adenocarcinoma(111;0.0485)		TTGGAGATTTCTGTGGAAGAG	0.597		NaN	Mis		ALL								0	0	0	1	0	5	14				
SLC35D1	23169	broad.mit.edu	37	1	67518490	67518490	+	Silent	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:67518490G>C	uc001ddk.2	-	3	672	c.288C>G	c.(286-288)GTC>GTG	p.V96V	SLC35D1_uc010oph.1_Silent_p.V17V	NM_015139	NP_055954	Q9NTN3	S35D1_HUMAN	solute carrier family 35 (UDP-glucuronic	96					chondroitin sulfate biosynthetic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	integral to endoplasmic reticulum membrane	UDP-glucuronic acid transmembrane transporter activity|UDP-N-acetylgalactosamine transmembrane transporter activity				0					Lorazepam(DB00186)	CAGGAAACTTGACTACTCTGA	0.393		NaN											0	0	0	1	0	62	44				
CRYZ	1429	broad.mit.edu	37	1	75188928	75188928	+	Silent	SNP	A	A	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:75188928A>T	uc001dgk.2	-	4	643	c.138T>A	c.(136-138)GGT>GGA	p.G46G	CRYZ_uc001dgj.2_Silent_p.G46G|CRYZ_uc001dgl.2_Silent_p.G46G|CRYZ_uc001dgm.2_5'UTR	NM_001130042	NP_001123514	Q08257	QOR_HUMAN	crystallin, zeta isoform a	46					protein homotetramerization|visual perception|xenobiotic catabolic process	cytosol|Golgi apparatus	mRNA 3'-UTR binding|NADPH binding|NADPH:quinone reductase activity|zinc ion binding				0					Dicumarol(DB00266)	CGGGGTTGACACCACATGCAT	0.378		NaN											0	0	0	1	0	64	38				
LMO4	8543	broad.mit.edu	37	1	87805743	87805743	+	Missense_Mutation	SNP	C	C	T	rs139269304		TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:87805743C>T	uc001dmi.2	+	4	1127	c.347C>T	c.(346-348)TCT>TTT	p.S116F	LMO4_uc001dmj.2_Missense_Mutation_p.S116F	NM_006769	NP_006760	P61968	LMO4_HUMAN	LIM domain only 4	116	LIM zinc-binding 2.				neural tube closure|transcription from RNA polymerase II promoter	transcription factor complex	sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding				0		Lung NSC(277;0.179)		all cancers(265;0.00456)|Epithelial(280;0.0148)|BRCA - Breast invasive adenocarcinoma(282;0.153)		TTTACATGCTCTACCTGCCGG	0.403		NaN											0	0	0	1	0	55	45				
RPAP2	79871	broad.mit.edu	37	1	92767046	92767046	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:92767046G>C	uc001dot.2	+	3	242	c.133G>C	c.(133-135)GAA>CAA	p.E45Q	RPAP2_uc009wdh.2_RNA|GLMN_uc001dor.2_5'Flank|GLMN_uc009wdg.2_5'Flank|GLMN_uc001dos.2_5'Flank	NM_024813	NP_079089	Q8IXW5	RPAP2_HUMAN	RNA polymerase II associated protein 2	45	Potential.					integral to membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)	1		all_lung(203;0.0565)|Lung NSC(277;0.152)|Glioma(108;0.222)		all cancers(265;0.00647)|GBM - Glioblastoma multiforme(16;0.0234)|Epithelial(280;0.115)		AGCTGAACTAGAAGCAGCTGT	0.328		NaN											0	0	0	1	0	17	24				
ABCA4	24	broad.mit.edu	37	1	94473258	94473258	+	Silent	SNP	T	T	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:94473258T>G	uc001dqh.2	-	43	6041	c.5937A>C	c.(5935-5937)ACA>ACC	p.T1979T	ABCA4_uc001dqi.1_Silent_p.T98T	NM_000350	NP_000341	P78363	ABCA4_HUMAN	ATP-binding cassette, sub-family A member 4	1979	ABC transporter 2.|Cytoplasmic.|ATP 2 (Potential).				phototransduction, visible light|visual perception	integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(4)|skin(4)|central_nervous_system(2)|upper_aerodigestive_tract(1)|breast(1)	12		all_lung(203;0.000757)|Lung NSC(277;0.00335)		all cancers(265;0.00432)|GBM - Glioblastoma multiforme(16;0.00715)|Epithelial(280;0.171)		TGAATGTGGTTGTTTTGCCGG	0.547		NaN											0	0	0	1	0	20	44				
ABCD3	5825	broad.mit.edu	37	1	94941201	94941201	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:94941201G>C	uc001dqn.3	+	7	637	c.535G>C	c.(535-537)GAC>CAC	p.D179H	ABCD3_uc001dqm.3_Missense_Mutation_p.D179H|ABCD3_uc010oto.1_Missense_Mutation_p.D203H|ABCD3_uc010otp.1_Missense_Mutation_p.D106H|ABCD3_uc009wdr.2_Missense_Mutation_p.D179H	NM_002858	NP_002849	P28288	ABCD3_HUMAN	ATP-binding cassette, sub-family D, member 3	179	ABC transmembrane type-1.|Interaction with PEX19.				peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(1)	1		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		GGGGAATCTGGACAACAGAAT	0.303		NaN											0	0	0	1	0	16	22				
COL11A1	1301	broad.mit.edu	37	1	103488306	103488306	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:103488306C>T	uc001dul.2	-	8	1555	c.1237G>A	c.(1237-1239)GAA>AAA	p.E413K	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.E425K|COL11A1_uc001dun.2_Missense_Mutation_p.E374K|COL11A1_uc009weh.2_Intron	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	413	Nonhelical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging	p.F413V(1)		ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		ACGCTTGTTTCTGTAATATCA	0.328		NaN											0	0	0	1	0	26	45				
KIAA1324	57535	broad.mit.edu	37	1	109715160	109715160	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:109715160G>T	uc001dwq.2	+	6	802	c.666G>T	c.(664-666)AAG>AAT	p.K222N	KIAA1324_uc009wex.1_Missense_Mutation_p.K222N|KIAA1324_uc009wey.2_Missense_Mutation_p.K222N|KIAA1324_uc010ovg.1_Missense_Mutation_p.K120N	NM_020775	NP_065826	Q6UXG2	K1324_HUMAN	hypothetical protein LOC57535 precursor	222	Extracellular (Potential).				macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	5		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		GGTGGATGAAGACCACAGAGA	0.502		NaN											1	0	0.0477658	1	0.0479071	8	30				
KIAA1324	57535	broad.mit.edu	37	1	109715167	109715167	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:109715167G>A	uc001dwq.2	+	6	809	c.673G>A	c.(673-675)GAG>AAG	p.E225K	KIAA1324_uc009wex.1_Missense_Mutation_p.E225K|KIAA1324_uc009wey.2_Missense_Mutation_p.E225K|KIAA1324_uc010ovg.1_Missense_Mutation_p.E123K	NM_020775	NP_065826	Q6UXG2	K1324_HUMAN	hypothetical protein LOC57535 precursor	225	Extracellular (Potential).				macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	5		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		GAAGACCACAGAGAAAGGATG	0.512		NaN											0	0	0	1	0	9	30				
AMPD2	271	broad.mit.edu	37	1	110163738	110163738	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:110163738G>A	uc009wfh.1	+	2	645	c.103G>A	c.(103-105)GAG>AAG	p.E35K	AMPD2_uc009wfg.1_Intron|AMPD2_uc001dyb.1_Intron|AMPD2_uc001dyc.1_Missense_Mutation_p.E35K|AMPD2_uc010ovr.1_Silent_p.Q3Q|AMPD2_uc010ovs.1_5'Flank	NM_004037	NP_004028	Q01433	AMPD2_HUMAN	adenosine monophosphate deaminase 2 (isoform L)	35					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			ovary(2)|breast(1)	3		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0425)|all cancers(265;0.0884)|Colorectal(144;0.109)|Epithelial(280;0.111)|LUSC - Lung squamous cell carcinoma(189;0.228)		GGATGTGGCAGAGCCAGGCCC	0.687		NaN											0	0	0	1	0	4	4				
AMPD2	271	broad.mit.edu	37	1	110169425	110169425	+	Silent	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:110169425G>C	uc009wfh.1	+	7	1313	c.771G>C	c.(769-771)CTG>CTC	p.L257L	AMPD2_uc009wfg.1_RNA|AMPD2_uc001dyb.1_Silent_p.L176L|AMPD2_uc001dyc.1_Silent_p.L257L|AMPD2_uc010ovr.1_Silent_p.L182L|AMPD2_uc010ovs.1_Silent_p.L139L|AMPD2_uc001dyd.1_Silent_p.L138L|AMPD2_uc001dye.1_5'Flank	NM_004037	NP_004028	Q01433	AMPD2_HUMAN	adenosine monophosphate deaminase 2 (isoform L)	257					purine base metabolic process|purine ribonucleoside monophosphate biosynthetic process|purine-containing compound salvage	cytosol	AMP deaminase activity|metal ion binding			ovary(2)|breast(1)	3		all_epithelial(167;2.5e-05)|all_lung(203;0.000135)|Lung NSC(277;0.000269)|Breast(1374;0.244)		Lung(183;0.0425)|all cancers(265;0.0884)|Colorectal(144;0.109)|Epithelial(280;0.111)|LUSC - Lung squamous cell carcinoma(189;0.228)		ACATGGCCCTGTCCCTGCAGA	0.622		NaN											0	0	0	1	0	10	46				
PTPN22	26191	broad.mit.edu	37	1	114402061	114402061	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:114402061T>C	uc001eds.2	-	2	239	c.109A>G	c.(109-111)AAG>GAG	p.K37E	uc001edv.1_Intron|PTPN22_uc009wgq.2_Missense_Mutation_p.K37E|PTPN22_uc010owo.1_5'UTR|PTPN22_uc001edt.2_Missense_Mutation_p.K37E|PTPN22_uc009wgr.2_Missense_Mutation_p.K37E|PTPN22_uc009wgs.2_Missense_Mutation_p.K37E|PTPN22_uc001edu.2_Missense_Mutation_p.K37E	NM_015967	NP_057051	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type	37	Tyrosine-protein phosphatase.				negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			kidney(2)|lung(1)|skin(1)	4	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCCTTGTACTTGGTAGATTGC	0.363		NaN											0	0	0	1	0	65	37				
TTF2	8458	broad.mit.edu	37	1	117617798	117617798	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:117617798G>C	uc001egy.2	+	5	612	c.592G>C	c.(592-594)GAG>CAG	p.E198Q	TTF2_uc001egx.1_Missense_Mutation_p.E198Q	NM_003594	NP_003585	Q9UNY4	TTF2_HUMAN	transcription termination factor, RNA polymerase	198					mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|termination of RNA polymerase II transcription	cytoplasm|spliceosomal complex|transcription elongation factor complex	ATP binding|ATP-dependent helicase activity|DNA binding|DNA-dependent ATPase activity|protein binding|zinc ion binding			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;4.23e-06)|all_epithelial(167;3.65e-07)|all_lung(203;2.81e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0553)|Colorectal(144;0.179)|LUSC - Lung squamous cell carcinoma(189;0.19)		GAAGCAAGAAGAGGGAGCAGA	0.418		NaN											0	0	0	1	0	18	54				
FAM46C	54855	broad.mit.edu	37	1	118166265	118166265	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:118166265G>C	uc001ehe.2	+	2	974	c.775G>C	c.(775-777)GAC>CAC	p.D259H		NM_017709	NP_060179	Q5VWP2	FA46C_HUMAN	hypothetical protein LOC54855	259											0	Lung SC(450;0.225)	all_cancers(81;0.000101)|all_lung(203;3.4e-06)|all_epithelial(167;4.98e-06)|Lung NSC(69;2.33e-05)		Lung(183;0.0576)|LUSC - Lung squamous cell carcinoma(189;0.192)|Colorectal(144;0.247)		CAGGCCCACAGACCAGGAAGA	0.512		NaN								Multiple Myeloma(3;1.13e-06)			0	0	0	1	0	16	52				
NOTCH2	4853	broad.mit.edu	37	1	120539792	120539792	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:120539792C>T	uc001eik.2	-	4	835	c.579G>A	c.(577-579)CAG>CAA	p.Q193Q	NOTCH2_uc001eil.2_Silent_p.Q193Q|NOTCH2_uc001eim.3_Silent_p.Q110Q	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	193	Extracellular (Potential).|EGF-like 5; calcium-binding (Potential).				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGCCACCATGCTGGCAGTGTC	0.567		NaN	N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				0	0	0	1	0	13	103				
NOTCH2	4853	broad.mit.edu	37	1	120539834	120539834	+	Silent	SNP	A	A	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:120539834A>G	uc001eik.2	-	4	793	c.537T>C	c.(535-537)TGT>TGC	p.C179C	NOTCH2_uc001eil.2_Silent_p.C179C|NOTCH2_uc001eim.3_Silent_p.C96C	NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	179	Extracellular (Potential).|EGF-like 4.				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		CATCAGTCTCACATTTCTGCC	0.552		NaN	N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				0	0	0	1	0	15	116				
PRKAB2	5565	broad.mit.edu	37	1	146639436	146639436	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:146639436G>T	uc001epe.2	-	3	378	c.233C>A	c.(232-234)CCC>CAC	p.P78H	PRKAB2_uc010ozm.1_Intron|PRKAB2_uc010ozn.1_Intron|PRKAB2_uc009wjf.1_Missense_Mutation_p.P78H	NM_005399	NP_005390	O43741	AAKB2_HUMAN	AMP-activated protein kinase beta 2	78					carnitine shuttle|cell cycle arrest|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm				lung(2)|skin(1)	3	all_hematologic(923;0.0487)				Adenosine monophosphate(DB00131)	GATAACAGTGGGCCGGGCCTG	0.527		NaN											1	0	2.48941e-46	1	2.82244e-46	92	166				
PRKAB2	5565	broad.mit.edu	37	1	146639438	146639438	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:146639438C>T	uc001epe.2	-	3	376	c.231G>A	c.(229-231)CGG>CGA	p.R77R	PRKAB2_uc010ozm.1_Intron|PRKAB2_uc010ozn.1_Intron|PRKAB2_uc009wjf.1_Silent_p.R77R	NM_005399	NP_005390	O43741	AAKB2_HUMAN	AMP-activated protein kinase beta 2	77					carnitine shuttle|cell cycle arrest|energy reserve metabolic process|fatty acid biosynthetic process|insulin receptor signaling pathway|regulation of fatty acid biosynthetic process|regulation of fatty acid oxidation	cytosol|nucleoplasm				lung(2)|skin(1)	3	all_hematologic(923;0.0487)				Adenosine monophosphate(DB00131)	TAACAGTGGGCCGGGCCTGCT	0.522		NaN											0	0	0	1	0	90	161				
PLEKHO1	51177	broad.mit.edu	37	1	150129184	150129184	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:150129184G>A	uc001ett.2	+	4	676	c.398G>A	c.(397-399)CGA>CAA	p.R133Q	PLEKHO1_uc001etr.2_5'UTR|PLEKHO1_uc001ets.2_5'UTR|PLEKHO1_uc001etu.2_5'UTR	NM_016274	NP_057358	Q53GL0	PKHO1_HUMAN	pleckstrin homology domain containing, family O	133	Interaction with capping proteins (CPs).			R->E: No effect on binding to capping proteins; when associated with E-135.|R->A: No effect on binding to capping proteins and loss of phospholipid binding; when associated with A-135 and A-137.		cytoplasm|nucleus|plasma membrane				lung(1)	1	Lung NSC(24;7.78e-28)|Breast(34;0.00211)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCCATCACCCGAGCCAAGAAC	0.587		NaN											0	0	0	1	0	11	77				
APH1A	51107	broad.mit.edu	37	1	150240428	150240428	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:150240428G>A	uc001ety.1	-	2	535	c.213C>T	c.(211-213)CTC>CTT	p.L71L	APH1A_uc010pbx.1_Intron|APH1A_uc001etz.1_Silent_p.L71L|APH1A_uc001eua.1_Silent_p.L71L|APH1A_uc010pby.1_Intron|APH1A_uc001eub.1_Intron|APH1A_uc010pbz.1_Intron	NM_001077628	NP_001071096	Q96BI3	APH1A_HUMAN	anterior pharynx defective 1 homolog A isoform	71	Helical; Name=3; (Potential).				amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum membrane|Golgi cisterna membrane|integral to plasma membrane	protein binding			ovary(1)|lung(1)	2	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			CAAAAATCAGGAGGCCGTACT	0.557		NaN											0	0	0	1	0	20	115				
HORMAD1	84072	broad.mit.edu	37	1	150689625	150689625	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:150689625C>G	uc001evk.1	-	3	273	c.167G>C	c.(166-168)AGA>ACA	p.R56T	HORMAD1_uc001evl.1_Missense_Mutation_p.R56T|HORMAD1_uc001evm.1_Missense_Mutation_p.K6N	NM_032132	NP_115508	Q86X24	HORM1_HUMAN	HORMA domain containing 1	56	HORMA.				blastocyst development|cell differentiation|meiotic DNA double-strand break formation|meiotic recombination checkpoint|meiotic sister chromatid cohesion|mitosis|oogenesis|regulation of homologous chromosome segregation|spermatogenesis|synaptonemal complex assembly	chromosome|nucleus				ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.23e-52)|all_epithelial(9;4.68e-43)|all_lung(15;5.74e-35)|Lung NSC(24;2.09e-31)|Breast(34;0.0009)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;2.32e-23)|all cancers(9;5.21e-23)|OV - Ovarian serous cystadenocarcinoma(6;6.72e-15)|BRCA - Breast invasive adenocarcinoma(12;0.000479)|LUSC - Lung squamous cell carcinoma(543;0.171)			ATCTAGATATCTTGTTCCATA	0.318		NaN											0	0	0	1	0	25	127				
SEMA6C	10500	broad.mit.edu	37	1	151108989	151108989	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:151108989G>C	uc001ewu.2	-	12	1341	c.1041C>G	c.(1039-1041)TTC>TTG	p.F347L	SEMA6C_uc001ewv.2_Missense_Mutation_p.F347L|SEMA6C_uc001eww.2_Missense_Mutation_p.F307L|SEMA6C_uc010pcq.1_Missense_Mutation_p.F347L	NM_030913	NP_112175	Q9H3T2	SEM6C_HUMAN	semaphorin Y precursor	347	Extracellular (Potential).|Sema.					integral to membrane	receptor activity			ovary(1)|skin(1)	2	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TCTGCTCCTTGAACTTGCCCT	0.567		NaN											0	0	0	1	0	43	204				
FLG	2312	broad.mit.edu	37	1	152279938	152279938	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:152279938C>G	uc001ezu.1	-	3	7460	c.7424G>C	c.(7423-7425)GGA>GCA	p.G2475A		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2475	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GTAGTGGGATCCCTGCCTTCC	0.577		NaN							Ichthyosis				0	0	0	1	0	136	337				
FLG	2312	broad.mit.edu	37	1	152281452	152281452	+	Silent	SNP	A	A	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:152281452A>T	uc001ezu.1	-	3	5946	c.5910T>A	c.(5908-5910)TCT>TCA	p.S1970S		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1970	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGCTGTCTGCAGAGTGCCCGT	0.557		NaN							Ichthyosis				0	0	0	1	0	106	569				
FLG	2312	broad.mit.edu	37	1	152283396	152283396	+	Silent	SNP	A	A	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:152283396A>T	uc001ezu.1	-	3	4002	c.3966T>A	c.(3964-3966)TCT>TCA	p.S1322S	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1322	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGCTGTCTGCAGAGTGCCCGT	0.358		NaN							Ichthyosis				0	0	0	1	0	14	302				
S100A8	6279	broad.mit.edu	37	1	153362985	153362985	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:153362985C>G	uc001fbs.2	-	2	82	c.27G>C	c.(25-27)TTG>TTC	p.L9F		NM_002964	NP_002955	P05109	S10A8_HUMAN	S100 calcium-binding protein A8	9					chemotaxis	cytoplasm|cytoskeleton|plasma membrane	calcium ion binding|protein binding				0	all_lung(78;2.81e-33)|Lung NSC(65;9.54e-32)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.171)			TGATAGAGTTCAAGGCTTTCT	0.507		NaN											0	0	0	1	0	53	223				
ILF2	3608	broad.mit.edu	37	1	153638142	153638142	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:153638142C>T	uc001fcr.2	-	7	538	c.457G>A	c.(457-459)GAA>AAA	p.E153K	ILF2_uc010pdy.1_Missense_Mutation_p.E115K|ILF2_uc009wok.2_Intron|ILF2_uc009wol.1_Missense_Mutation_p.E115K	NM_004515	NP_004506	Q12905	ILF2_HUMAN	interleukin enhancer binding factor 2	153	DZF.				immune response|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|ribonucleoprotein complex	ATP binding|DNA binding|double-stranded RNA binding|protein binding|transferase activity				0	all_lung(78;1.84e-32)|Lung NSC(65;6.67e-31)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.171)			TGCAAACCTTCAGAAGGATCC	0.388		NaN											0	0	0	1	0	8	145				
FDPS	2224	broad.mit.edu	37	1	155288696	155288696	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:155288696C>G	uc001fkc.2	+	8	1042	c.823C>G	c.(823-825)CCT>GCT	p.P275A	RAG1AP1_uc010pey.1_Intron|FDPS_uc001fkd.2_Missense_Mutation_p.P209A|FDPS_uc001fke.2_Missense_Mutation_p.P275A|FDPS_uc001fkf.2_Missense_Mutation_p.P209A|C1orf104_uc001fkh.1_Intron|RUSC1_uc001fkj.2_5'Flank|RUSC1_uc001fkk.2_5'Flank|RUSC1_uc009wqn.1_5'Flank	NM_002004	NP_001995	P14324	FPPS_HUMAN	farnesyl diphosphate synthase isoform a	275					cholesterol biosynthetic process|interspecies interaction between organisms|isoprenoid biosynthetic process	cytosol|nucleus	dimethylallyltranstransferase activity|geranyltranstransferase activity|metal ion binding				0	Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;2.03e-10)|all cancers(21;5.23e-10)|BRCA - Breast invasive adenocarcinoma(34;0.000549)|LUSC - Lung squamous cell carcinoma(543;0.127)		Alendronate(DB00630)|Ibandronate(DB00710)|Pamidronate(DB00282)|Risedronate(DB00884)|Zoledronate(DB00399)	CTTCTACCTTCCTATAGCTGC	0.498		NaN											0	0	0	1	0	70	86				
ASH1L	55870	broad.mit.edu	37	1	155448304	155448304	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:155448304G>C	uc009wqq.2	-	3	4837	c.4357C>G	c.(4357-4359)CTT>GTT	p.L1453V	ASH1L_uc001fkt.2_Missense_Mutation_p.L1453V|ASH1L_uc009wqr.1_Missense_Mutation_p.L1453V	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	1453					cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			CTGGTTGTAAGAAAGGCCTCC	0.493		NaN											0	0	0	1	0	26	112				
BCAN	63827	broad.mit.edu	37	1	156622477	156622477	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:156622477C>T	uc001fpp.2	+	8	2071	c.1735C>T	c.(1735-1737)CGA>TGA	p.R579*	BCAN_uc001fpo.2_Nonsense_Mutation_p.R579*	NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	579					cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					TGGGGTCCCTCGAGGAGAGAG	0.642		NaN											0	0	0	1	0	24	32				
SPTA1	6708	broad.mit.edu	37	1	158615287	158615287	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:158615287G>A	uc001fst.1	-	28	4193	c.3994C>T	c.(3994-3996)CAG>TAG	p.Q1332*		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	1332	Spectrin 13.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					AGTTTTACCTGATGTCTCTCC	0.448		NaN											0	0	0	1	0	43	74				
OR6N1	128372	broad.mit.edu	37	1	158735776	158735776	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:158735776C>A	uc010piq.1	-	1	697	c.697G>T	c.(697-699)GGC>TGC	p.G233C		NM_001005185	NP_001005185	Q8NGY5	OR6N1_HUMAN	olfactory receptor, family 6, subfamily N,	233	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0378)					TTCCTCTTGCCGGCAGCTGAG	0.498		NaN											1	0	3.62531e-18	1	4.02504e-18	32	104				
OR10J1	26476	broad.mit.edu	37	1	159409997	159409997	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:159409997G>C	uc010piv.1	+	1	449	c.449G>C	c.(448-450)AGG>ACG	p.R150T	uc001fts.3_Intron	NM_012351	NP_036483	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J,	150	Cytoplasmic (Potential).				sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0429)					ATGAACAAGAGGCTGCGTATC	0.488		NaN											0	0	0	1	0	11	155				
CCDC19	25790	broad.mit.edu	37	1	159857685	159857685	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:159857685C>G	uc001fui.2	-	5	552	c.534G>C	c.(532-534)CAG>CAC	p.Q178H	CCDC19_uc009wtb.2_RNA|CCDC19_uc001fuj.2_RNA|CCDC19_uc001fuk.2_Missense_Mutation_p.Q93H|CCDC19_uc001ful.2_Missense_Mutation_p.Q93H|CCDC19_uc009wtc.1_Missense_Mutation_p.Q178H	NM_012337	NP_036469	Q9UL16	CCD19_HUMAN	nasopharyngeal epithelium specific protein 1	178	Potential.					mitochondrion|soluble fraction				ovary(1)	1	all_hematologic(112;0.0597)		BRCA - Breast invasive adenocarcinoma(70;0.151)			TGTTGGCTCTCTGCAGGAGGT	0.552		NaN											0	0	0	1	0	94	101				
PIGM	93183	broad.mit.edu	37	1	160000857	160000857	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:160000857G>C	uc001fuv.1	-	1	927	c.673C>G	c.(673-675)CGG>GGG	p.R225G		NM_145167	NP_660150	Q9H3S5	PIGM_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	225	Cytoplasmic (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane				ovary(2)|skin(1)	3	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			AGCACAGCCCGATTACACAGC	0.488		NaN											0	0	0	1	0	35	127				
ATP1A2	477	broad.mit.edu	37	1	160098576	160098576	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:160098576G>A	uc001fvc.2	+	9	1284	c.1152G>A	c.(1150-1152)ATG>ATA	p.M384I	ATP1A2_uc001fvb.2_Missense_Mutation_p.M384I|ATP1A2_uc010piz.1_Missense_Mutation_p.M229I|ATP1A2_uc001fvd.2_Missense_Mutation_p.M120I|ATP1A2_uc009wtg.1_Missense_Mutation_p.M72I	NM_000702	NP_000693	P50993	AT1A2_HUMAN	Na+/K+ -ATPase alpha 2 subunit proprotein	384	Cytoplasmic (Potential).				ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			central_nervous_system(3)|ovary(2)|skin(2)	7	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			AGAACCGCATGACCGTCGCCC	0.592		NaN											0	0	0	1	0	28	73				
LY9	4063	broad.mit.edu	37	1	160766040	160766040	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:160766040G>A	uc001fwu.2	+	1	113	c.63G>A	c.(61-63)CAG>CAA	p.Q21Q	LY9_uc001fwt.2_Silent_p.Q21Q|LY9_uc010pjs.1_Silent_p.Q21Q|LY9_uc001fwv.2_Silent_p.Q21Q|LY9_uc001fww.2_Silent_p.Q21Q|LY9_uc001fwx.2_Silent_p.Q21Q	NM_002348	NP_002339	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9 isoform a	21					cell adhesion|immunoglobulin mediated immune response	integral to membrane				ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			GTAAGCCACAGAGGAGTCAGC	0.498		NaN											0	0	0	1	0	29	112				
LY9	4063	broad.mit.edu	37	1	160794037	160794037	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:160794037C>G	uc001fwu.2	+	9	1947	c.1897C>G	c.(1897-1899)CAG>GAG	p.Q633E	LY9_uc001fwv.2_Missense_Mutation_p.Q619E|LY9_uc001fww.2_Missense_Mutation_p.Q543E|LY9_uc001fwx.2_Intron|LY9_uc001fwz.2_Intron	NM_002348	NP_002339	Q9HBG7	LY9_HUMAN	lymphocyte antigen 9 isoform a	633	Cytoplasmic (Potential).				cell adhesion|immunoglobulin mediated immune response	integral to membrane				ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			ACGGAAACCTCAGGTGGTGAG	0.488		NaN											0	0	0	1	0	22	101				
HSD17B7	51478	broad.mit.edu	37	1	162767598	162767598	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:162767598G>A	uc001gci.2	+	4	434	c.339G>A	c.(337-339)GTG>GTA	p.V113V	HSD17B7_uc009wuv.2_RNA	NM_016371	NP_057455	P56937	DHB7_HUMAN	hydroxysteroid (17-beta) dehydrogenase 7	113	Extracellular (Potential).				cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	3-keto sterol reductase activity|estradiol 17-beta-dehydrogenase activity			ovary(1)	1	all_hematologic(112;0.115)				NADH(DB00157)	TCAGAAAAGTGATTCATATGT	0.433		NaN											0	0	0	1	0	5	35				
GPA33	10223	broad.mit.edu	37	1	167024974	167024974	+	Silent	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:167024974G>C	uc001gea.1	-	5	1028	c.684C>G	c.(682-684)GTC>GTG	p.V228V		NM_005814	NP_005805	Q99795	GPA33_HUMAN	transmembrane glycoprotein A33 precursor	228	Extracellular (Potential).					integral to plasma membrane	receptor activity				0						TACGAGATCTGACGGCCACCG	0.557		NaN											0	0	0	1	0	19	78				
DCAF6	55827	broad.mit.edu	37	1	168035698	168035698	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:168035698G>C	uc001gew.2	+	17	2649	c.2407G>C	c.(2407-2409)GAT>CAT	p.D803H	DCAF6_uc001gev.2_Missense_Mutation_p.D823H|DCAF6_uc001gex.2_Missense_Mutation_p.D894H|DCAF6_uc010plk.1_Missense_Mutation_p.D863H|DCAF6_uc001gey.2_Missense_Mutation_p.D676H|DCAF6_uc001gez.2_Missense_Mutation_p.D106H	NM_001017977	NP_001017977	Q58WW2	DCAF6_HUMAN	IQ motif and WD repeats 1 isoform b	803					positive regulation of transcription from RNA polymerase II promoter	CUL4 RING ubiquitin ligase complex|nucleus	ligand-dependent nuclear receptor transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3						AAAACTTGCTGATGAAGTAAG	0.289		NaN											0	0	0	1	0	4	55				
C1orf156	92342	broad.mit.edu	37	1	169762167	169762167	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:169762167C>G	uc001ggn.2	-	2	948	c.670G>C	c.(670-672)GAT>CAT	p.D224H	C1orf112_uc001ggj.2_Intron|C1orf112_uc001ggo.2_5'Flank|uc010plt.1_5'Flank|C1orf112_uc001ggp.2_5'Flank|C1orf112_uc001ggq.2_5'Flank|C1orf112_uc009wvt.2_5'Flank	NM_033418	NP_219486	O95568	MET18_HUMAN	hypothetical protein MGC9084	224						cytoplasm	protein methyltransferase activity				0	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GTTACTTCATCAATCACCATA	0.373		NaN											0	0	0	1	0	35	173				
BAT2L2	23215	broad.mit.edu	37	1	171482304	171482304	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:171482304G>C	uc010pmg.1	+	3	543	c.277G>C	c.(277-279)GAA>CAA	p.E93Q	BAT2L2_uc001ghq.1_Missense_Mutation_p.E95Q|BAT2L2_uc001ghr.1_Missense_Mutation_p.E95Q	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	93							protein C-terminus binding				0						GCAACATGAAGAAGAAAAGTG	0.398		NaN											0	0	0	1	0	7	26				
BAT2L2	23215	broad.mit.edu	37	1	171501557	171501557	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:171501557G>C	uc010pmg.1	+	12	1590	c.1324G>C	c.(1324-1326)GAT>CAT	p.D442H	BAT2L2_uc001ghr.1_Missense_Mutation_p.D444H	NM_015172	NP_055987	Q9Y520	PRC2C_HUMAN	HBxAg transactivated protein 2	442							protein C-terminus binding				0						AGCTGATGAAGATGAAATATG	0.473		NaN											0	0	0	1	0	10	29				
MYOC	4653	broad.mit.edu	37	1	171621212	171621212	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:171621212C>T	uc001ghu.2	-	1	562	c.540G>A	c.(538-540)CTG>CTA	p.L180L	MYOC_uc010pmk.1_Silent_p.L122L	NM_000261	NP_000252	Q99972	MYOC_HUMAN	myocilin precursor	180	Potential.				anatomical structure morphogenesis	cilium|extracellular space|rough endoplasmic reticulum	structural molecule activity			lung(1)	1	all_cancers(6;5.47e-10)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					GGCCCCTTCTCAGCCTTGCTA	0.562		NaN											0	0	0	1	0	82	275				
SLC9A11	284525	broad.mit.edu	37	1	173523900	173523900	+	Nonsense_Mutation	SNP	G	G	C	rs138213092		TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:173523900G>C	uc001giz.2	-	11	1692	c.1269C>G	c.(1267-1269)TAC>TAG	p.Y423*	SLC9A11_uc009wwe.2_Intron|SLC9A11_uc010pmq.1_RNA	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	423	Helical; (Potential).				sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						GAGTCATCACGTATGAATTTA	0.328		NaN											0	0	0	1	0	27	135				
TNR	7143	broad.mit.edu	37	1	175375427	175375427	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:175375427C>G	uc001gkp.1	-	1	505	c.424G>C	c.(424-426)GAG>CAG	p.E142Q	TNR_uc009wwu.1_Missense_Mutation_p.E142Q|TNR_uc010pmz.1_Missense_Mutation_p.E142Q	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	142	Potential.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					TCCAGCATCTCGATCCGGCTC	0.602		NaN											0	0	0	1	0	20	76				
RALGPS2	55103	broad.mit.edu	37	1	178848093	178848093	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:178848093G>C	uc001glz.2	+	10	1140	c.802G>C	c.(802-804)GAA>CAA	p.E268Q	RALGPS2_uc001gly.1_Missense_Mutation_p.E268Q|RALGPS2_uc010pnb.1_Missense_Mutation_p.E268Q	NM_152663	NP_689876	Q86X27	RGPS2_HUMAN	Ral GEF with PH domain and SH3 binding motif 2	268	Ras-GEF.				small GTPase mediated signal transduction	cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity|protein binding				0						GTATATAGAAGAACTACAAAA	0.338		NaN											0	0	0	1	0	10	32				
SMG7	9887	broad.mit.edu	37	1	183515224	183515224	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:183515224G>C	uc001gqg.2	+	17	2616	c.2494G>C	c.(2494-2496)GAG>CAG	p.E832Q	SMG7_uc010pob.1_Missense_Mutation_p.E815Q|SMG7_uc001gqf.2_Missense_Mutation_p.E786Q|SMG7_uc001gqh.2_Missense_Mutation_p.E786Q|SMG7_uc001gqi.2_Missense_Mutation_p.E744Q|SMG7_uc010poc.1_Missense_Mutation_p.E790Q	NM_173156	NP_775179	Q92540	SMG7_HUMAN	SMG-7 homolog isoform 1	832	Gln/Pro-rich.				mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of dephosphorylation	cytoplasm|intermediate filament cytoskeleton|nucleus	protein phosphatase 2A binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						AAAACTGTTTGAGCCGTCATT	0.463		NaN											0	0	0	1	0	16	55				
EDEM3	80267	broad.mit.edu	37	1	184686740	184686740	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:184686740G>C	uc010pok.1	-	12	1440	c.1179C>G	c.(1177-1179)TTC>TTG	p.F393L	EDEM3_uc010pol.1_RNA|EDEM3_uc010pom.1_Missense_Mutation_p.F393L	NM_025191	NP_079467	Q9BZQ6	EDEM3_HUMAN	ER degradation enhancer, mannosidase alpha-like	393					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	endoplasmic reticulum lumen|endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			skin(1)	1						AGTGTACTCTGAAATCTGTGG	0.294		NaN											0	0	0	1	0	7	18				
HMCN1	83872	broad.mit.edu	37	1	186083224	186083224	+	Missense_Mutation	SNP	G	G	T	rs138705216	by1000genomes	TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:186083224G>T	uc001grq.1	+	73	11474	c.11245G>T	c.(11245-11247)GAT>TAT	p.D3749Y		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	3749	Ig-like C2-type 36.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						ATGGAGAAAGGATGGAGCTGT	0.388		NaN											1	0	9.8876e-21	1	1.10381e-20	38	35				
F13B	2165	broad.mit.edu	37	1	197019986	197019986	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:197019986G>A	uc001gtt.1	-	10	1623	c.1579C>T	c.(1579-1581)CCT>TCT	p.P527S		NM_001994	NP_001985	P05160	F13B_HUMAN	coagulation factor XIII B subunit precursor	527	Sushi 9.				blood coagulation	extracellular region				upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						ATAAGAGGAGGAGATGTGCAC	0.313		NaN											0	0	0	1	0	16	21				
CAMSAP1L1	23271	broad.mit.edu	37	1	200708985	200708985	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:200708985G>C	uc001gvl.2	+	1	300	c.30G>C	c.(28-30)ATG>ATC	p.M10I	CAMSAP1L1_uc001gvk.2_Missense_Mutation_p.M10I|CAMSAP1L1_uc001gvm.2_Missense_Mutation_p.M10I	NM_203459	NP_982284	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein	10						cytoplasm|microtubule	protein binding			ovary(2)|large_intestine(1)|pancreas(1)	4						CCAGGGAGATGAGAAAGACGT	0.592		NaN											0	0	0	1	0	7	14				
BTG2	7832	broad.mit.edu	37	1	203276294	203276294	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:203276294C>G	uc001gzq.2	+	2	276	c.205C>G	c.(205-207)CGC>GGC	p.R69G	FMOD_uc010pqi.1_Intron|uc009xao.1_5'Flank|uc001gzp.1_5'Flank|BTG2_uc009xap.1_RNA	NM_006763	NP_006754	P78543	BTG2_HUMAN	B-cell translocation gene 2	69					DNA repair|neuron projection development|positive regulation of nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			ovary(1)|kidney(1)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.203)			CCGCTGCATTCGCATCAACCA	0.612		NaN											0	0	0	1	0	15	19		Valid		
PIK3C2B	5287	broad.mit.edu	37	1	204400860	204400860	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:204400860A>G	uc001haw.2	-	29	4696	c.4217T>C	c.(4216-4218)TTT>TCT	p.F1406S	PIK3C2B_uc010pqv.1_Missense_Mutation_p.F1378S	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	1406	PX.				cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			GAACTCCTCAAAGGTCCGCTG	0.527		NaN									OREG0014134	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	7	134				
PIK3C2B	5287	broad.mit.edu	37	1	204438084	204438084	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:204438084G>A	uc001haw.2	-	3	1326	c.847C>T	c.(847-849)CAG>TAG	p.Q283*	PIK3C2B_uc010pqv.1_Nonsense_Mutation_p.Q283*|PIK3C2B_uc001hax.1_Nonsense_Mutation_p.Q283*|PIK3C2B_uc009xbd.1_RNA	NM_002646	NP_002637	O00750	P3C2B_HUMAN	phosphoinositide-3-kinase, class 2 beta	283	Interaction with GRB2.				cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding			lung(2)|breast(2)|stomach(1)|prostate(1)|central_nervous_system(1)	7	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			GGGGGCACCTGAGGGGGCATA	0.642		NaN											0	0	0	1	0	23	79				
INTS7	25896	broad.mit.edu	37	1	212120009	212120009	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:212120009C>T	uc001hiw.1	-	18	2460	c.2355G>A	c.(2353-2355)CTG>CTA	p.L785L	INTS7_uc009xdb.1_Intron|INTS7_uc001hix.1_Silent_p.L661L|INTS7_uc001hiy.1_Silent_p.L771L|INTS7_uc010pta.1_Silent_p.L736L	NM_015434	NP_056249	Q9NVH2	INT7_HUMAN	integrator complex subunit 7	785					snRNA processing	integrator complex	protein binding				0				OV - Ovarian serous cystadenocarcinoma(81;0.00584)|all cancers(67;0.0318)|Epithelial(68;0.0852)		GGGGAACTTTCAGCAAAGCAA	0.343		NaN											0	0	0	1	0	41	25				
PTPN14	5784	broad.mit.edu	37	1	214542945	214542945	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:214542945C>T	uc001hkk.1	-	17	3397	c.3126G>A	c.(3124-3126)ACG>ACA	p.T1042T		NM_005401	NP_005392	Q15678	PTN14_HUMAN	protein tyrosine phosphatase, non-receptor type	1042	Tyrosine-protein phosphatase.				lymphangiogenesis	cytoplasm|cytoskeleton	protein tyrosine phosphatase activity|receptor tyrosine kinase binding			breast(2)|ovary(1)|kidney(1)|skin(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00181)|all cancers(67;0.00194)|Epithelial(68;0.0157)|GBM - Glioblastoma multiforme(131;0.155)		TTCGAAACTTCGTGGTGACCT	0.488		NaN											0	0	0	1	0	67	153				
IARS2	55699	broad.mit.edu	37	1	220273958	220273958	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:220273958C>G	uc001hmc.2	+	3	621	c.517C>G	c.(517-519)CAG>GAG	p.Q173E		NM_018060	NP_060530	Q9NSE4	SYIM_HUMAN	mitochondrial isoleucine tRNA synthetase	173					isoleucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|isoleucine-tRNA ligase activity			ovary(2)|skin(2)	4				GBM - Glioblastoma multiforme(131;0.0554)	L-Isoleucine(DB00167)	TAGAGAAGCTCAGAATCTTTC	0.348		NaN											0	0	0	1	0	10	37				
FAM177B	400823	broad.mit.edu	37	1	222923383	222923383	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:222923383G>A	uc001hnt.2	+	6	726	c.460G>A	c.(460-462)GAG>AAG	p.E154K	uc001hnr.1_Intron|FAM177B_uc009xeb.2_RNA	NM_207468	NP_997351	A6PVY3	F177B_HUMAN	hypothetical protein LOC400823	154										ovary(1)	1						GGATGTGACAGAGGCCATTCC	0.522		NaN											0	0	0	1	0	14	53				
CNIH3	149111	broad.mit.edu	37	1	224804936	224804936	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:224804936C>T	uc001hos.1	+	1	758	c.60C>T	c.(58-60)CTC>CTT	p.L20L		NM_152495	NP_689708	Q8TBE1	CNIH3_HUMAN	cornichon homolog 3	20	Helical; (Potential).				intracellular signal transduction|regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic shaft|postsynaptic membrane					0	Breast(184;0.218)			GBM - Glioblastoma multiforme(131;0.073)		GCGCTGCGCTCATCTTCTTCG	0.557		NaN											0	0	0	1	0	37	178				
WNT3A	89780	broad.mit.edu	37	1	228210569	228210569	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:228210569C>T	uc001hrq.1	+	2	351	c.273C>T	c.(271-273)GTC>GTT	p.V91V	WNT3A_uc001hrp.1_Silent_p.V91V	NM_033131	NP_149122	P56704	WNT3A_HUMAN	wingless-type MMTV integration site family,	91					axis specification|cell proliferation in forebrain|cell-cell signaling|cellular response to retinoic acid|convergent extension|dermatome development|dorsal/ventral neural tube patterning|embryonic pattern specification|extracellular matrix organization|hemopoietic stem cell proliferation|hippocampus development|inner ear morphogenesis|mammary gland development|midbrain-hindbrain boundary development|negative regulation of fat cell differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of neuron projection development|notochord development|palate development|paraxial mesodermal cell fate commitment|positive regulation of catenin import into nucleus|positive regulation of peptidyl-serine phosphorylation|positive regulation of protein binding|positive regulation of receptor internalization|positive regulation of transcription from RNA polymerase II promoter|signalosome assembly|tail morphogenesis|Wnt receptor signaling pathway involved in forebrain neuroblast division|Wnt receptor signaling pathway, calcium modulating pathway	cell surface|early endosome|extracellular space|late endosome|membrane raft|plasma membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|frizzled-2 binding|receptor agonist activity|signal transducer activity|transcription coactivator activity			ovary(1)	1		Prostate(94;0.0405)				GCACCACCGTCCACGACAGCC	0.642		NaN											0	0	0	1	0	21	27				
OBSCN	84033	broad.mit.edu	37	1	228558384	228558384	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:228558384C>G	uc009xez.1	+	93	20215	c.20171C>G	c.(20170-20172)TCC>TGC	p.S6724C	OBSCN_uc001hsr.1_Missense_Mutation_p.S1353C	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	6724					apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				TCCCAGAAATCCATGCCTGCG	0.632		NaN											0	0	0	1	0	18	26				
CAPN9	10753	broad.mit.edu	37	1	230937333	230937333	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:230937333G>T	uc001htz.1	+	20	2177	c.2064G>T	c.(2062-2064)ATG>ATT	p.M688I	CAPN9_uc009xfg.1_Missense_Mutation_p.M625I|CAPN9_uc001hua.1_Missense_Mutation_p.M662I	NM_006615	NP_006606	O14815	CAN9_HUMAN	calpain 9 isoform 1	688	Domain IV.				digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)	1	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)				ATTTGACAATGAACATCTGAG	0.532		NaN											1	0	1.22574e-08	1	1.29716e-08	22	63				
SIPA1L2	57568	broad.mit.edu	37	1	232564265	232564265	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:232564265C>G	uc001hvg.2	-	15	4460	c.4302G>C	c.(4300-4302)CAG>CAC	p.Q1434H	SIPA1L2_uc001hvf.2_Missense_Mutation_p.Q508H	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	1434					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				CCACCACTGTCTGATGCTGAG	0.443		NaN											0	0	0	1	0	27	46				
SIPA1L2	57568	broad.mit.edu	37	1	232650028	232650028	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:232650028T>C	uc001hvg.2	-	1	1216	c.1058A>G	c.(1057-1059)AAA>AGA	p.K353R		NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	353					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				GTTTTTCCTTTTCCCCACATT	0.493		NaN											0	0	0	1	0	20	87				
LYST	1130	broad.mit.edu	37	1	235887452	235887453	+	Missense_Mutation	DNP	GA	GA	TT			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:235887452_235887453GA>TT	uc001hxj.2	-	39	9365_9366	c.9190_9191TC>AA	c.(9190-9192)TCA>AAA	p.S3064K	LYST_uc001hxi.2_Missense_Mutation_p.S288K	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	3064					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			CCAGGAAAATGATGCTGGTTCC	0.317		NaN							Chediak-Higashi_syndrome				0	0	0	1	0	14	161				
ACTN2	88	broad.mit.edu	37	1	236899015	236899015	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:236899015G>A	uc001hyf.2	+	8	982	c.778G>A	c.(778-780)GAG>AAG	p.E260K	ACTN2_uc001hyg.2_Missense_Mutation_p.E15K|ACTN2_uc009xgi.1_Intron|ACTN2_uc010pxu.1_Intron	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	260					focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			TGCGGGCGCGGAGCAGGTACT	0.498		NaN											0	0	0	1	0	26	15				
FH	2271	broad.mit.edu	37	1	241663871	241663871	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:241663871G>A	uc001hyx.2	-	9	1288	c.1256C>T	c.(1255-1257)TCA>TTA	p.S419L		NM_000143	NP_000134	P07954	FUMH_HUMAN	fumarate hydratase precursor	419					fumarate metabolic process|tricarboxylic acid cycle	cell junction|mitochondrial matrix|tricarboxylic acid cycle enzyme complex	fumarate hydratase activity			lung(3)|ovary(1)|skin(1)	5	Ovarian(103;0.103)	all_cancers(173;2.37e-314)|all_epithelial(177;5.17e-286)|Breast(1374;1.06e-10)|Acute lymphoblastic leukemia(190;4.93e-10)|all_neural(198;0.00118)	OV - Ovarian serous cystadenocarcinoma(106;0.0214)	Colorectal(1306;2.33e-53)|COAD - Colon adenocarcinoma(196;1.05e-44)|KIRC - Kidney renal clear cell carcinoma(1967;0.000109)		CAGCCTGGCTGAGTGTAACAC	0.323		NaN	Mis|N|F			lieomyomatosis|renal			Hereditary_Leiomyomatosis_and_Renal_Cell_Cancer				0	0	0	1	0	51	24				
KMO	8564	broad.mit.edu	37	1	241714300	241714300	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr1:241714300C>G	uc009xgp.2	+	4	333	c.268C>G	c.(268-270)CTT>GTT	p.L90V	KMO_uc001hyy.2_Missense_Mutation_p.L90V|KMO_uc009xgo.1_Missense_Mutation_p.L90V	NM_003679	NP_003670	O15229	KMO_HUMAN	kynurenine 3-monooxygenase	90					pyridine nucleotide biosynthetic process|response to salt stress	cytosol|integral to membrane|mitochondrial outer membrane	electron carrier activity|flavin adenine dinucleotide binding|kynurenine 3-monooxygenase activity|NAD(P)H oxidase activity			ovary(2)	2	Ovarian(103;0.103)|all_lung(81;0.23)		OV - Ovarian serous cystadenocarcinoma(106;0.0176)			GATCCACTCTCTTTCAGGAAA	0.398		NaN											0	0	0	1	0	51	101				
ITIH2	3698	broad.mit.edu	37	10	7786827	7786827	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr10:7786827C>G	uc001ijs.2	+	19	2644	c.2482C>G	c.(2482-2484)CTT>GTT	p.L828V		NM_002216	NP_002207	P19823	ITIH2_HUMAN	inter-alpha globulin inhibitor H2 polypeptide	828					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|pancreas(1)|skin(1)	3						TTCTGTTTTACTTCATCGTGT	0.423		NaN											0	0	0	1	0	12	86				
CELF2	10659	broad.mit.edu	37	10	11047353	11047353	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr10:11047353G>T	uc001iki.3	+	1	95	c.3G>T	c.(1-3)ATG>ATT	p.M1I	CELF2_uc010qbi.1_5'UTR|CELF2_uc010qbj.1_Missense_Mutation_p.M1I	NM_001025077	NP_001020248	O95319	CELF2_HUMAN	CUG triplet repeat, RNA binding protein 2	1	Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusion.				mRNA processing|regulation of heart contraction	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding				0						ATAGAAGCATGCGCTGTCCCA	0.393		NaN											1	0	1.15505e-17	1	1.27961e-17	38	216				
FRMD4A	55691	broad.mit.edu	37	10	13698952	13698952	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr10:13698952G>C	uc001ims.2	-	22	2989	c.2637C>G	c.(2635-2637)TTC>TTG	p.F879L	FRMD4A_uc009xjf.1_Missense_Mutation_p.F879L	NM_018027	NP_060497	Q9P2Q2	FRM4A_HUMAN	FERM domain containing 4A	879						cytoplasm|cytoskeleton	binding			ovary(1)|skin(1)|pancreas(1)	3						AGCTCTCCTTGAACAGGCCGC	0.716		NaN											0	0	0	1	0	8	14				
HSPA14	51182	broad.mit.edu	37	10	14909867	14909867	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr10:14909867G>C	uc001inf.2	+	12	1480	c.1339G>C	c.(1339-1341)GAT>CAT	p.D447H		NM_016299	NP_057383	Q0VDF9	HSP7E_HUMAN	heat shock 70kDa protein 14 isoform 1	447					'de novo' cotranslational protein folding	cytosol	ATP binding|protein binding			ovary(2)|breast(2)|lung(1)	5						CTATGAGTCTGATGGGAAGAA	0.433		NaN											0	0	0	1	0	22	103				
DCLRE1C	64421	broad.mit.edu	37	10	14995952	14995952	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr10:14995952C>G	uc001inn.2	-	1	143	c.58G>C	c.(58-60)GAT>CAT	p.D20H	DCLRE1C_uc010qbx.1_Missense_Mutation_p.D20H|DCLRE1C_uc001inl.2_5'UTR|DCLRE1C_uc009xji.2_5'UTR|DCLRE1C_uc001inm.2_5'UTR|DCLRE1C_uc001ino.2_5'UTR|DCLRE1C_uc009xjh.2_RNA|DCLRE1C_uc001inp.2_5'UTR|DCLRE1C_uc001inq.2_5'UTR|DCLRE1C_uc001inr.2_5'UTR	NM_001033855	NP_001029027	Q96SD1	DCR1C_HUMAN	artemis protein isoform a	20					DNA recombination	nucleus	5'-3' exonuclease activity|single-stranded DNA specific endodeoxyribonuclease activity			ovary(1)	1						TTCTCCCTATCGAAGCGGTCT	0.647		NaN						Involved_in_tolerance_or_repair_of_DNA_crosslinks|NHEJ					0	0	0	1	0	22	95				
NMT2	9397	broad.mit.edu	37	10	15154865	15154865	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr10:15154865G>C	uc001inz.1	-	10	1352	c.1268C>G	c.(1267-1269)TCA>TGA	p.S423*	NMT2_uc001ioa.1_Nonsense_Mutation_p.S410*|NMT2_uc009xjo.1_Nonsense_Mutation_p.S423*|NMT2_uc010qbz.1_Nonsense_Mutation_p.S235*	NM_004808	NP_004799	O60551	NMT2_HUMAN	N-myristoyltransferase 2	423					N-terminal protein myristoylation|protein lipoylation	Golgi apparatus|plasma membrane	glycylpeptide N-tetradecanoyltransferase activity			ovary(1)	1						GTTGTAGAATGAGTAGGCGGC	0.552		NaN											0	0	0	1	0	25	137				
KIAA1217	56243	broad.mit.edu	37	10	24669900	24669900	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr10:24669900G>C	uc001iru.3	+	3	860	c.457G>C	c.(457-459)GAG>CAG	p.E153Q	KIAA1217_uc001irs.2_Missense_Mutation_p.E73Q|KIAA1217_uc001irt.3_Missense_Mutation_p.E153Q|KIAA1217_uc010qcy.1_Missense_Mutation_p.E153Q|KIAA1217_uc010qcz.1_Missense_Mutation_p.E153Q|KIAA1217_uc001irv.1_Missense_Mutation_p.E3Q|KIAA1217_uc010qda.1_RNA	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	153					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						AGCCATGTCTGAGGGGGATGC	0.552		NaN											0	0	0	1	0	31	29				
MRPS16	51021	broad.mit.edu	37	10	75011600	75011600	+	Silent	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr10:75011600G>C	uc001jts.1	-	2	406	c.195C>G	c.(193-195)CTC>CTG	p.L65L	DNAJC9_uc010qkg.1_5'Flank|MRPS16_uc010qkh.1_RNA|MRPS16_uc001jtt.1_RNA|uc001jtu.1_5'Flank	NM_016065	NP_057149	Q9Y3D3	RT16_HUMAN	mitochondrial ribosomal protein S16 precursor	65					translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome				0	Prostate(51;0.0119)					TGAGGGCAACGAGTTTTTCTC	0.537		NaN											0	0	0	1	0	57	26				
PTEN	5728	broad.mit.edu	37	10	89725134	89725134	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr10:89725134G>A	uc001kfb.2	+	10	2148	c.1117G>A	c.(1117-1119)GAA>AAA	p.E373K		NM_000314	NP_000305	P60484	PTEN_HUMAN	phosphatase and tensin homolog	373					activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.R55fs*1(4)|p.Y27fs*1(2)|p.N212fs*1(2)|p.G165_*404del(1)		endometrium(831)|central_nervous_system(657)|skin(121)|haematopoietic_and_lymphoid_tissue(101)|large_intestine(99)|prostate(97)|breast(73)|lung(65)|ovary(58)|thyroid(29)|stomach(29)|upper_aerodigestive_tract(25)|cervix(24)|liver(20)|vulva(17)|kidney(15)|NS(14)|soft_tissue(13)|urinary_tract(12)|eye(8)|pancreas(6)|salivary_gland(5)|bone(5)|biliary_tract(4)|autonomic_ganglia(2)|meninges(2)|testis(1)|oesophagus(1)	2334		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		TAGTGACAATGAACCTGATCA	0.388		31	D|Mis|N|F|S		glioma| prostate|endometrial	harmartoma|glioma| prostate|endometrial			Proteus_syndrome|Cowden_syndrome|Juvenile_Polyposis|Hereditary_Mixed_Polyposis_Syndrome_type_1|Bannayan-Riley-Ruvalcaba_syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			0	0	0	1	0	10	17				
BTAF1	9044	broad.mit.edu	37	10	93699793	93699793	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr10:93699793G>C	uc001khr.2	+	3	321	c.223G>C	c.(223-225)GAG>CAG	p.E75Q	BTAF1_uc009xua.1_RNA	NM_003972	NP_003963	O14981	BTAF1_HUMAN	BTAF1 RNA polymerase II, B-TFIID transcription	75					negative regulation of transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0846)				AAATGTACCTGAGTGGAATCC	0.353		NaN											0	0	0	1	0	8	14				
PDE6C	5146	broad.mit.edu	37	10	95400704	95400704	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr10:95400704G>T	uc001kiu.3	+	14	1903	c.1765G>T	c.(1765-1767)GAT>TAT	p.D589Y		NM_006204	NP_006195	P51160	PDE6C_HUMAN	phosphodiesterase 6C	589					visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			ovary(2)|kidney(1)|skin(1)	4		Colorectal(252;0.123)				GTACTACACAGATCTCGAAGC	0.363		NaN											1	0	0.00244969	1	0.00248141	15	29				
HELLS	3070	broad.mit.edu	37	10	96317928	96317928	+	Missense_Mutation	SNP	A	A	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr10:96317928A>T	uc001kjt.2	+	4	414	c.309A>T	c.(307-309)AAA>AAT	p.K103N	HELLS_uc001kjs.2_Missense_Mutation_p.K87N|HELLS_uc009xul.2_Missense_Mutation_p.K103N|HELLS_uc009xum.2_Missense_Mutation_p.K103N|HELLS_uc009xun.2_5'UTR|HELLS_uc009xuo.2_Missense_Mutation_p.K103N|HELLS_uc001kju.2_5'UTR|HELLS_uc009xup.2_RNA|HELLS_uc009xuq.2_5'UTR|HELLS_uc009xur.2_RNA	NM_018063	NP_060533	Q9NRZ9	HELLS_HUMAN	helicase, lymphoid-specific	103	Potential.				cell division|centromeric heterochromatin formation|lymphocyte proliferation|maintenance of DNA methylation|methylation-dependent chromatin silencing|mitosis|transcription, DNA-dependent	centromeric heterochromatin|nucleus	ATP binding|DNA binding|helicase activity			ovary(1)|kidney(1)	2		Colorectal(252;0.0429)		all cancers(201;2.13e-05)		TGGAGAGAAAAAAGGAGTCTT	0.269		NaN											0	0	0	1	0	20	23				
PIK3AP1	118788	broad.mit.edu	37	10	98383279	98383279	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr10:98383279C>A	uc001kmq.2	-	11	1813	c.1685G>T	c.(1684-1686)AGT>ATT	p.S562I	PIK3AP1_uc001kmo.2_Missense_Mutation_p.S161I|PIK3AP1_uc001kmp.2_Missense_Mutation_p.S384I	NM_152309	NP_689522	Q6ZUJ8	BCAP_HUMAN	phosphoinositide-3-kinase adaptor protein 1	562						cytoplasm|plasma membrane				upper_aerodigestive_tract(3)|ovary(1)|skin(1)	5		Colorectal(252;0.0442)		Epithelial(162;6.29e-08)|all cancers(201;3.18e-06)		CCGCTCTTGACTTTTTTCTGC	0.343		NaN											1	0	1.00798e-23	1	1.13023e-23	58	81				
FAM178A	55719	broad.mit.edu	37	10	102672946	102672946	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr10:102672946C>G	uc001krt.3	+	1	621	c.79C>G	c.(79-81)CTG>GTG	p.L27V	FAM178A_uc001krq.3_RNA|FAM178A_uc001krr.1_Missense_Mutation_p.L27V|FAM178A_uc001krs.2_Missense_Mutation_p.L27V	NM_018121	NP_060591	Q8IX21	F178A_HUMAN	hypothetical protein LOC55719 isoform 1	27											0						GCGCTGCCATCTGAGACCCGG	0.697		NaN											0	0	0	1	0	5	2				
TACC2	10579	broad.mit.edu	37	10	124008642	124008642	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr10:124008642G>A	uc001lfv.2	+	21	8991	c.8631G>A	c.(8629-8631)CTG>CTA	p.L2877L	TACC2_uc001lfw.2_Silent_p.L1023L|TACC2_uc009xzx.2_Silent_p.L2755L|TACC2_uc010qtv.1_Silent_p.L2804L|TACC2_uc001lfx.2_Silent_p.L504L|TACC2_uc001lfy.2_Silent_p.L500L|TACC2_uc001lfz.2_Silent_p.L955L|TACC2_uc001lga.2_Silent_p.L925L|TACC2_uc009xzy.2_Silent_p.L937L|TACC2_uc001lgb.2_Silent_p.L835L	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	2877	Potential.					microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				ACCAGGCCCTGAAGGTGCACG	0.602		NaN											0	0	0	1	0	3	5				
PLEKHA1	59338	broad.mit.edu	37	10	124175485	124175485	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr10:124175485C>G	uc001lge.1	+	7	702	c.579C>G	c.(577-579)ATC>ATG	p.I193M	PLEKHA1_uc001lgf.1_Missense_Mutation_p.I193M|PLEKHA1_uc001lgg.1_Missense_Mutation_p.I193M|PLEKHA1_uc001lgh.2_Missense_Mutation_p.I193M	NM_001001974	NP_001001974	Q9HB21	PKHA1_HUMAN	pleckstrin homology domain containing, family A	193	PH 2.				B cell receptor signaling pathway|cellular response to hydrogen peroxide|establishment of protein localization|negative regulation of protein kinase B signaling cascade|phosphatidylinositol 3-kinase cascade|ruffle organization	cytoplasm|nucleus|ruffle membrane	PDZ domain binding|phosphatidylinositol-3,4-bisphosphate binding			kidney(1)	1		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GTGCGGTTATCAAAGCTGGAT	0.348		NaN											0	0	0	1	0	16	1				
ART1	417	broad.mit.edu	37	11	3680949	3680949	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:3680949C>A	uc001lye.1	+	3	301	c.200C>A	c.(199-201)ACG>AAG	p.T67K	ART1_uc009yeb.1_Missense_Mutation_p.T67K	NM_004314	NP_004305	P52961	NAR1_HUMAN	ADP-ribosyltransferase 1 precursor	67					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane|sarcoplasmic reticulum membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity				0		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0351)|LUSC - Lung squamous cell carcinoma(625;0.195)	Becaplermin(DB00102)	CTCAACCACACGGAGTTCCAG	0.602		NaN											1	0	0.000274275	1	0.000279497	8	4				
OR52B4	143496	broad.mit.edu	37	11	4389102	4389102	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:4389102G>C	uc010qye.1	-	1	424	c.424C>G	c.(424-426)CTG>GTG	p.L142V		NM_001005161	NP_001005161	Q8NGK2	O52B4_HUMAN	olfactory receptor, family 52, subfamily B,	142	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0249)|all_neural(188;0.0577)		Epithelial(150;1.57e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0826)|LUSC - Lung squamous cell carcinoma(625;0.19)		TTCTTGATCAGAGCATTTGTA	0.388		NaN											0	0	0	1	0	14	31				
TUB	7275	broad.mit.edu	37	11	8120357	8120357	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:8120357C>T	uc001mga.2	+	9	1200	c.1051C>T	c.(1051-1053)CAG>TAG	p.Q351*	TUB_uc010rbk.1_Nonsense_Mutation_p.Q357*|TUB_uc001mfy.2_Nonsense_Mutation_p.Q406*	NM_177972	NP_813977	P50607	TUB_HUMAN	tubby isoform b	351					phagocytosis|positive regulation of phagocytosis|response to stimulus	cytoplasm|extracellular region|nucleus|plasma membrane				ovary(1)	1		all_lung(207;6.91e-20)|Lung NSC(207;3.36e-17)		Epithelial(150;1.69e-62)|BRCA - Breast invasive adenocarcinoma(625;8.54e-06)|LUSC - Lung squamous cell carcinoma(625;0.000184)		AGTCAACCCTCAGAAGGCCTC	0.507		NaN									OREG0020732	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	17	66				
IPO7	10527	broad.mit.edu	37	11	9450610	9450610	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:9450610G>A	uc001mho.2	+	14	1600	c.1458G>A	c.(1456-1458)GTG>GTA	p.V486V		NM_006391	NP_006382	O95373	IPO7_HUMAN	importin 7	486					interspecies interaction between organisms|signal transduction	Golgi apparatus|nuclear pore|soluble fraction	protein transporter activity|Ran GTPase binding|small GTPase regulator activity			lung(1)|breast(1)	2				all cancers(16;8.29e-09)|Epithelial(150;4.76e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0217)		TTTGTGAAGTGAAGTTCAAAA	0.388		NaN											0	0	0	1	0	27	22				
UEVLD	55293	broad.mit.edu	37	11	18555896	18555896	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:18555896G>A	uc001mot.2	-	11	1309	c.1229C>T	c.(1228-1230)TCT>TTT	p.S410F	UEVLD_uc001mou.2_Intron|UEVLD_uc010rde.1_Missense_Mutation_p.S280F|UEVLD_uc010rdf.1_Missense_Mutation_p.S388F|UEVLD_uc010rdg.1_Missense_Mutation_p.S280F|UEVLD_uc001mov.2_Intron	NM_001040697	NP_001035787	Q8IX04	UEVLD_HUMAN	ubiquitin-conjugating enzyme E2-like isoform a	410					cellular carbohydrate metabolic process|protein modification process|protein transport		binding|oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor				0						AGCTGATACAGAATGCACTTT	0.299		NaN											0	0	0	1	0	4	44				
SPTY2D1	144108	broad.mit.edu	37	11	18637593	18637593	+	Silent	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:18637593G>C	uc001moy.2	-	3	444	c.228C>G	c.(226-228)CTC>CTG	p.L76L	SPTY2D1_uc010rdi.1_Silent_p.L76L	NM_194285	NP_919261	Q68D10	SPT2_HUMAN	SPT2, Suppressor of Ty, domain containing 1	76	Potential.									breast(1)	1						TGTCATGTTTGAGCTCAATTC	0.388		NaN											0	0	0	1	0	33	38				
LUZP2	338645	broad.mit.edu	37	11	24998163	24998163	+	Missense_Mutation	SNP	A	A	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:24998163A>T	uc001mqs.2	+	8	783	c.549A>T	c.(547-549)CAA>CAT	p.Q183H	LUZP2_uc009yif.2_Missense_Mutation_p.Q97H|LUZP2_uc009yig.2_Missense_Mutation_p.Q141H	NM_001009909	NP_001009909	Q86TE4	LUZP2_HUMAN	leucine zipper protein 2 precursor	183	Potential.|Leucine-zipper.					extracellular region				ovary(1)|skin(1)	2						ATCTGGAACAAAAATTAGCTG	0.343		NaN											0	0	0	1	0	9	35				
CCDC73	493860	broad.mit.edu	37	11	32632777	32632777	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:32632777C>G	uc001mtv.2	-	17	2975	c.2931G>C	c.(2929-2931)TTG>TTC	p.L977F		NM_001008391	NP_001008392	Q6ZRK6	CCD73_HUMAN	sarcoma antigen NY-SAR-79	977										ovary(1)|central_nervous_system(1)	2	Breast(20;0.112)					TCCAGTTATTCAAAGTGTCAG	0.393		NaN											0	0	0	1	0	26	78				
ALX4	60529	broad.mit.edu	37	11	44331236	44331236	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:44331236C>T	uc001myb.2	-	1	481	c.377G>A	c.(376-378)CGA>CAA	p.R126Q		NM_021926	NP_068745	Q9H161	ALX4_HUMAN	aristaless-like homeobox 4	126					hair follicle development						0						GCAGGCGCCTCGCTGCAAGTA	0.473		NaN											0	0	0	1	0	4	0				
PRDM11	56981	broad.mit.edu	37	11	45246160	45246160	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:45246160G>C	uc001myo.2	+	8	1486	c.1237G>C	c.(1237-1239)GAG>CAG	p.E413Q		NM_020229	NP_064614	Q9NQV5	PRD11_HUMAN	PR domain containing 11	413										upper_aerodigestive_tract(1)	1						AGGCCAATTGGAGGATGAAGA	0.577		NaN											0	0	0	1	0	38	63				
OR5D13	390142	broad.mit.edu	37	11	55540964	55540964	+	Missense_Mutation	SNP	G	G	C	rs117263837	byFrequency	TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:55540964G>C	uc010ril.1	+	1	51	c.51G>C	c.(49-51)TTG>TTC	p.L17F		NM_001001967	NP_001001967	Q8NGL4	OR5DD_HUMAN	olfactory receptor, family 5, subfamily D,	17	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)|skin(1)	3		all_epithelial(135;0.196)				TTATTCTCTTGGGTTTTTCAG	0.383		NaN											0	0	0	1	0	37	244				
OR5M10	390167	broad.mit.edu	37	11	56344278	56344278	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:56344278C>T	uc001niz.1	-	1	920	c.920G>A	c.(919-921)GGA>GAA	p.G307E		NM_001004741	NP_001004741	Q6IEU7	OR5MA_HUMAN	olfactory receptor, family 5, subfamily M,	307	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AAAGGATTTTCCCCTAATCAT	0.373		NaN											0	0	0	1	0	75	251				
OSBP	5007	broad.mit.edu	37	11	59368846	59368846	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:59368846G>A	uc001noc.1	-	5	1514	c.1034C>T	c.(1033-1035)TCT>TTT	p.S345F	OSBP_uc009ymr.1_5'Flank	NM_002556	NP_002547	P22059	OSBP1_HUMAN	oxysterol binding protein	345					lipid transport	Golgi membrane	oxysterol binding			large_intestine(1)	1		all_epithelial(135;0.000236)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		CCCTTTGCCAGAGCAGCACTG	0.393		NaN											0	0	0	1	0	13	43				
DAGLA	747	broad.mit.edu	37	11	61488339	61488339	+	Missense_Mutation	SNP	A	A	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:61488339A>C	uc001nsa.2	+	3	395	c.284A>C	c.(283-285)CAG>CCG	p.Q95P		NM_006133	NP_006124	Q9Y4D2	DGLA_HUMAN	neural stem cell-derived dendrite regulator	95	Cytoplasmic (Potential).				cell death|lipid catabolic process|platelet activation	integral to membrane|plasma membrane	acylglycerol lipase activity|metal ion binding|triglyceride lipase activity			ovary(2)|central_nervous_system(1)	3				READ - Rectum adenocarcinoma(4;0.219)		GACTCCATGCAGTACGTGCTC	0.542		NaN											0	0	0	1	0	20	44				
AHNAK	79026	broad.mit.edu	37	11	62289440	62289440	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:62289440G>A	uc001ntl.2	-	5	12749	c.12449C>T	c.(12448-12450)TCT>TTT	p.S4150F	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	4150					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TTTGGGCAGAGAAACGTCCAC	0.522		NaN											0	0	0	1	0	41	92				
TUT1	64852	broad.mit.edu	37	11	62348892	62348892	+	Silent	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:62348892G>C	uc001nto.2	-	3	707	c.669C>G	c.(667-669)GCC>GCG	p.A223A		NM_022830	NP_073741	Q9H6E5	STPAP_HUMAN	terminal uridylyl transferase 1, U6	185					mRNA cleavage|mRNA polyadenylation|snRNA processing	nuclear speck|nucleolus	ATP binding|enzyme binding|mRNA 3'-UTR binding|polynucleotide adenylyltransferase activity|RNA uridylyltransferase activity|zinc ion binding			central_nervous_system(1)|skin(1)	2						CCTGCATCAGGGCCACCACTA	0.587		NaN											0	0	0	1	0	6	23				
NXF1	10482	broad.mit.edu	37	11	62561884	62561884	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:62561884C>G	uc001nvf.1	-	19	1742	c.1606G>C	c.(1606-1608)GTG>CTG	p.V536L	TMEM223_uc001nve.2_5'Flank|NXF1_uc001nvg.1_3'UTR|NXF1_uc009yog.1_Missense_Mutation_p.V579L	NM_006362	NP_006353	Q9UBU9	NXF1_HUMAN	nuclear RNA export factor 1 isoform 1	536	NTF2.				gene expression|interspecies interaction between organisms	cytosol|nuclear speck	nucleotide binding|protein binding			skin(3)	3						GCATTCCGCACAAATAGCTCA	0.493		NaN											0	0	0	1	0	8	43				
SLC22A8	9376	broad.mit.edu	37	11	62760912	62760912	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:62760912C>T	uc001nwo.2	-	10	1649	c.1513G>A	c.(1513-1515)GAA>AAA	p.E505K	SLC22A8_uc001nwn.1_3'UTR|SLC22A8_uc001nwp.2_Missense_Mutation_p.E505K|SLC22A8_uc009yom.2_Missense_Mutation_p.E382K|SLC22A8_uc010rmm.1_Missense_Mutation_p.E414K|SLC22A8_uc009yon.2_Missense_Mutation_p.E505K	NM_004254	NP_004245	Q8TCC7	S22A8_HUMAN	solute carrier family 22 member 8	505	Extracellular (Potential).				response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			skin(2)|ovary(1)	3						TCCAGGTCTTCGATAGTCTCT	0.597		NaN											0	0	0	1	0	24	57				
PLCB3	5331	broad.mit.edu	37	11	64026396	64026396	+	Silent	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:64026396C>G	uc001nzb.2	+	12	1293	c.1293C>G	c.(1291-1293)TCC>TCG	p.S431S	PLCB3_uc009ypg.1_Silent_p.S431S|PLCB3_uc009yph.1_Silent_p.S364S|PLCB3_uc009ypi.2_Silent_p.S431S	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3	431	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						ACTGCCGCTCCATCTTTGGAG	0.637		NaN											0	0	0	1	0	9	21				
NRXN2	9379	broad.mit.edu	37	11	64457929	64457929	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:64457929G>A	uc001oar.2	-	6	1237	c.798C>T	c.(796-798)TCC>TCT	p.S266S	NRXN2_uc001oas.2_Intron|NRXN2_uc001oaq.2_5'UTR	NM_015080	NP_055895	P58401	NRX2B_HUMAN	neurexin 2 isoform alpha-1 precursor	Error:Variant_position_missing_in_P58401_after_alignment					cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						CCCCCCCCTCGGAGAACAGTA	0.647		NaN											0	0	0	1	0	14	9				
ATG2A	23130	broad.mit.edu	37	11	64673042	64673042	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:64673042G>T	uc001obx.2	-	24	3572	c.3457C>A	c.(3457-3459)CTG>ATG	p.L1153M	ATG2A_uc001obw.2_5'Flank	NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1153							protein binding			ovary(1)|central_nervous_system(1)	2						TACCTGAGCAGGAAGGTGGAG	0.617		NaN											1	0	5.4927e-09	1	5.81883e-09	8	3				
C11orf2	738	broad.mit.edu	37	11	64876860	64876860	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:64876860G>T	uc001ocr.1	+	6	1592	c.1552G>T	c.(1552-1554)GCC>TCC	p.A518S	TM7SF2_uc001oct.2_5'Flank|TM7SF2_uc010rny.1_5'Flank|TM7SF2_uc001ocu.2_5'Flank|TM7SF2_uc001ocv.2_5'Flank|C11orf2_uc001ocs.1_Missense_Mutation_p.A394S	NM_013265	NP_037397	Q9UID3	FFR_HUMAN	chromosome 11 open reading frame 2	518					lipid transport|protein transport	Golgi apparatus|integral to membrane					0						GAAGGGGGGTGCCACACCACC	0.617		NaN											1	0	3.59834e-05	1	3.70396e-05	6	36				
SYVN1	84447	broad.mit.edu	37	11	64895935	64895935	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:64895935C>T	uc001odb.2	-	16	1867	c.1773G>A	c.(1771-1773)GAG>GAA	p.E591E	SYVN1_uc001odc.2_Silent_p.E590E|SYVN1_uc009yqc.2_Silent_p.E539E	NM_172230	NP_757385	Q86TM6	SYVN1_HUMAN	synoviolin 1 isoform b	591	Cytoplasmic (Potential).				ER-associated protein catabolic process|response to stress	endoplasmic reticulum membrane|integral to membrane|nucleus	acid-amino acid ligase activity|protein binding|zinc ion binding			ovary(1)	1						CCTCAGGCATCTCCTCTGTGC	0.642		NaN											0	0	0	1	0	16	29				
KCNK7	10089	broad.mit.edu	37	11	65360568	65360568	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:65360568C>T	uc001oes.2	-	3	1056	c.832G>A	c.(832-834)GAG>AAG	p.E278K	KCNK7_uc001oeq.2_3'UTR|KCNK7_uc001oer.2_3'UTR|KCNK7_uc001oeu.2_3'UTR	NM_033347	NP_203133	Q9Y2U2	KCNK7_HUMAN	potassium channel, subfamily K, member 7 isoform	278	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity				0						CCTTGGTCCTCAGCAGTCACA	0.627		NaN											0	0	0	1	0	4	16				
SPTBN2	6712	broad.mit.edu	37	11	66458983	66458983	+	Silent	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:66458983G>C	uc001ojd.2	-	26	5409	c.5337C>G	c.(5335-5337)CTC>CTG	p.L1779L		NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1779	Spectrin 14.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						AGGCCTCGTTGAGACTGTCCT	0.672		NaN											0	0	0	1	0	8	29				
SPTBN2	6712	broad.mit.edu	37	11	66460498	66460498	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:66460498G>C	uc001ojd.2	-	24	5000	c.4928C>G	c.(4927-4929)ACC>AGC	p.T1643S		NM_006946	NP_008877	O15020	SPTN2_HUMAN	spectrin, beta, non-erythrocytic 2	1643	Spectrin 13.				actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			large_intestine(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						CTGGTGGATGGTCTGCGCGTA	0.677		NaN											0	0	0	1	0	31	80				
LRFN4	78999	broad.mit.edu	37	11	66625620	66625620	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:66625620C>T	uc001ojr.2	+	1	745	c.405C>T	c.(403-405)ATC>ATT	p.I135I	PC_uc001ojo.1_Intron|PC_uc001ojp.1_Intron|PC_uc001ojn.1_Intron|LRFN4_uc001ojq.1_Silent_p.I135I|LRFN4_uc001ojs.2_Silent_p.I135I	NM_024036	NP_076941	Q6PJG9	LRFN4_HUMAN	leucine rich repeat and fibronectin type III	135	LRR 4.|Extracellular (Potential).					integral to membrane					0						TGGGCCGCATCGCGCCGGGAG	0.682		NaN											0	0	0	1	0	61	17				
CORO1B	57175	broad.mit.edu	37	11	67207901	67207901	+	Missense_Mutation	SNP	C	C	G	rs149251927		TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:67207901C>G	uc001olj.1	-	6	802	c.766G>C	c.(766-768)GAG>CAG	p.E256Q	PTPRCAP_uc001oli.1_5'Flank|CORO1B_uc009yrs.1_RNA|CORO1B_uc001olk.1_Missense_Mutation_p.E256Q|CORO1B_uc009yrt.1_RNA|CORO1B_uc009yru.1_RNA|CORO1B_uc001oll.1_Missense_Mutation_p.E256Q	NM_020441	NP_065174	Q9BR76	COR1B_HUMAN	coronin, actin binding protein, 1B	256	WD 4.				actin cytoskeleton organization	actin cytoskeleton|cytoplasm	actin filament binding			large_intestine(1)|ovary(1)	2			BRCA - Breast invasive adenocarcinoma(15;3.26e-06)			ATGGGTTCCTCGAGGTTTTCC	0.622		NaN											0	0	0	1	0	8	20				
ARAP1	116985	broad.mit.edu	37	11	72412771	72412771	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:72412771G>A	uc001osu.2	-	16	2414	c.2225C>T	c.(2224-2226)CCG>CTG	p.P742L	ARAP1_uc001osv.2_Missense_Mutation_p.P742L|ARAP1_uc001osr.2_Missense_Mutation_p.P502L|ARAP1_uc001oss.2_Missense_Mutation_p.P497L|ARAP1_uc009yth.2_Missense_Mutation_p.P436L|ARAP1_uc010rre.1_Missense_Mutation_p.P497L|ARAP1_uc001osw.1_Missense_Mutation_p.P30L	NM_001040118	NP_001035207	Q96P48	ARAP1_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	742					actin filament reorganization involved in cell cycle|negative regulation of stress fiber assembly|positive regulation of Cdc42 GTPase activity|positive regulation of filopodium assembly|regulation of ARF GTPase activity|regulation of cell shape|regulation of cellular component movement|small GTPase mediated signal transduction	cytosol|Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|Rho GTPase activator activity|zinc ion binding			skin(1)	1						GCTCACGGTCGGCAGGACAAC	0.632		NaN											0	0	0	1	0	68	187				
RNF169	254225	broad.mit.edu	37	11	74547165	74547165	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:74547165C>G	uc001ovl.3	+	6	1530	c.1517C>G	c.(1516-1518)TCT>TGT	p.S506C	XRRA1_uc001ovm.2_Intron	NM_001098638	NP_001092108	Q8NCN4	RN169_HUMAN	ring finger protein 169	506							zinc ion binding			ovary(1)	1						CATTTCCCCTCTGTTAGCCAA	0.473		NaN											0	0	0	1	0	50	122				
GRM5	2915	broad.mit.edu	37	11	88241803	88241803	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:88241803G>A	uc001pcq.2	-	9	3796	c.3596C>T	c.(3595-3597)ACT>ATT	p.T1199I	GRM5_uc009yvm.2_Missense_Mutation_p.T1167I	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	1199	Cytoplasmic (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	TATGATAAGAGTGTCATATTT	0.602		NaN											0	0	0	1	0	8	18				
NOX4	50507	broad.mit.edu	37	11	89133452	89133452	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:89133452G>A	uc001pct.2	-	10	1181	c.942C>T	c.(940-942)GTC>GTT	p.V314V	NOX4_uc009yvr.2_Silent_p.V289V|NOX4_uc001pcu.2_Silent_p.V240V|NOX4_uc001pcw.2_Intron|NOX4_uc001pcx.2_Intron|NOX4_uc001pcv.2_Silent_p.V314V|NOX4_uc009yvo.2_Intron|NOX4_uc010rtu.1_Silent_p.V148V|NOX4_uc009yvp.2_Intron|NOX4_uc010rtv.1_Silent_p.V290V|NOX4_uc009yvq.2_Silent_p.V290V	NM_016931	NP_058627	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4 isoform a	314	FAD-binding FR-type.|Extracellular (Potential).|Mediates interaction with TLR4.				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				GATGACTCATGACCGAAATGA	0.433		NaN											0	0	0	1	0	12	54				
GRIA4	2893	broad.mit.edu	37	11	105775959	105775959	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:105775959G>C	uc001pix.2	+	9	1536	c.1090G>C	c.(1090-1092)GAC>CAC	p.D364H	GRIA4_uc001piu.1_Missense_Mutation_p.D364H|GRIA4_uc001piw.2_Missense_Mutation_p.D364H|GRIA4_uc009yxk.1_Missense_Mutation_p.D364H	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	364	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	TGTTCAGTTTGACCACTATGG	0.393		NaN											0	0	0	1	0	20	89				
NPAT	4863	broad.mit.edu	37	11	108032032	108032032	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:108032032C>T	uc001pjz.3	-	17	3883	c.3781G>A	c.(3781-3783)GAT>AAT	p.D1261N	NPAT_uc010rvv.1_Missense_Mutation_p.D317N	NM_002519	NP_002510	Q14207	NPAT_HUMAN	nuclear protein,  ataxia-telangiectasia locus	1261					positive regulation of transcription, DNA-dependent|regulation of transcription involved in G1/S phase of mitotic cell cycle	Cajal body	protein C-terminus binding|protein N-terminus binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			ovary(2)	2		all_cancers(61;2.31e-10)|all_epithelial(67;1.11e-06)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;1.05e-05)|Epithelial(105;3.01e-05)|all cancers(92;0.000816)|Colorectal(284;0.116)		TCACTACTATCAGCAAGCCTA	0.448		NaN											0	0	0	1	0	89	85				
EXPH5	23086	broad.mit.edu	37	11	108384109	108384109	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:108384109C>T	uc001pkk.2	-	6	2236	c.2125G>A	c.(2125-2127)GAA>AAA	p.E709K	EXPH5_uc010rvy.1_Missense_Mutation_p.E521K|EXPH5_uc010rvz.1_Missense_Mutation_p.E553K|EXPH5_uc010rwa.1_Missense_Mutation_p.E633K	NM_015065	NP_055880	Q8NEV8	EXPH5_HUMAN	exophilin 5 isoform a	709					intracellular protein transport		Rab GTPase binding			skin(3)|ovary(2)	5		all_cancers(61;3.99e-08)|Acute lymphoblastic leukemia(157;3.97e-05)|Melanoma(852;4.04e-05)|all_epithelial(67;0.000116)|all_hematologic(158;0.000315)|Breast(348;0.104)|all_neural(303;0.16)		Epithelial(105;8.1e-06)|BRCA - Breast invasive adenocarcinoma(274;1.22e-05)|all cancers(92;0.000129)|OV - Ovarian serous cystadenocarcinoma(223;0.11)|Colorectal(284;0.184)		TTGTCTTCTTCTGAAATAGAT	0.413		NaN											0	0	0	1	0	22	54				
DRD2	1813	broad.mit.edu	37	11	113286260	113286260	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:113286260G>A	uc001pnz.2	-	4	927	c.606C>T	c.(604-606)TTC>TTT	p.F202F	DRD2_uc010rwv.1_Silent_p.F201F|DRD2_uc001poa.3_Silent_p.F202F|DRD2_uc001pob.3_Silent_p.F202F|DRD2_uc009yyr.1_Silent_p.F202F	NM_000795	NP_000786	P14416	DRD2_HUMAN	dopamine receptor D2 isoform long	202	Helical; Name=5; (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			pancreas(1)|skin(1)	2		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	GGGTGACAATGAAGGGCACGT	0.597		NaN											0	0	0	1	0	27	43				
DSCAML1	57453	broad.mit.edu	37	11	117332172	117332172	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:117332172C>T	uc001prh.1	-	18	3588	c.3586G>A	c.(3586-3588)GAT>AAT	p.D1196N		NM_020693	NP_065744	Q8TD84	DSCL1_HUMAN	Down syndrome cell adhesion molecule like 1	1136	Fibronectin type-III 3.|Extracellular (Potential).				axonogenesis|brain development|cell fate determination|dorsal/ventral pattern formation|embryonic skeletal system morphogenesis|homophilic cell adhesion	cell surface|integral to membrane|plasma membrane	protein homodimerization activity			ovary(3)|large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)	8	all_hematologic(175;0.0487)	Breast(348;0.0424)|Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;9.12e-06)|Epithelial(105;0.00172)		TCACCCCCATCAACATAGAGG	0.602		NaN											0	0	0	1	0	27	44				
AMICA1	120425	broad.mit.edu	37	11	118071280	118071280	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:118071280G>T	uc001psk.2	-	7	994	c.820C>A	c.(820-822)CAG>AAG	p.Q274K	AMICA1_uc001psg.2_Missense_Mutation_p.Q84K|AMICA1_uc001psh.2_Missense_Mutation_p.Q235K|AMICA1_uc009yzw.1_RNA|AMICA1_uc001psi.2_Missense_Mutation_p.Q264K|AMICA1_uc001psj.2_Missense_Mutation_p.Q263K|AMICA1_uc010rxw.1_Missense_Mutation_p.Q235K|AMICA1_uc010rxx.1_Missense_Mutation_p.Q274K|AMICA1_uc001psl.1_Missense_Mutation_p.Q230K	NM_001098526	NP_001091996	Q86YT9	JAML1_HUMAN	adhesion molecule, interacts with CXADR antigen	274	Extracellular (Potential).				blood coagulation|cell adhesion|leukocyte migration|regulation of immune response	cell junction|integral to membrane				ovary(1)	1	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.4e-05)		ATCACCAACTGATTACCACCC	0.502		NaN											1	0	4.87955e-14	1	5.32458e-14	26	41				
MLL	4297	broad.mit.edu	37	11	118363895	118363895	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:118363895G>A	uc001pta.2	+	16	5142	c.5119G>A	c.(5119-5121)GAT>AAT	p.D1707N	MLL_uc001ptb.2_Missense_Mutation_p.D1710N	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1707	Bromo; divergent.				apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		GCAGCCTTTAGATCTAGAAGG	0.478		NaN	T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								0	0	0	1	0	16	96		Valid		
HYOU1	10525	broad.mit.edu	37	11	118923444	118923444	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:118923444C>G	uc001puu.2	-	9	1085	c.892G>C	c.(892-894)GAT>CAT	p.D298H	HYOU1_uc001put.2_Missense_Mutation_p.D263H|HYOU1_uc010ryu.1_Missense_Mutation_p.D318H|HYOU1_uc010ryv.1_Missense_Mutation_p.D187H|HYOU1_uc001pux.3_Missense_Mutation_p.D298H|HYOU1_uc010ryw.1_RNA|HYOU1_uc001puw.1_Missense_Mutation_p.D298H	NM_006389	NP_006380	Q9Y4L1	HYOU1_HUMAN	hypoxia up-regulated 1 precursor	298						endoplasmic reticulum lumen	ATP binding|protein binding				0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)|all_hematologic(192;0.207)		BRCA - Breast invasive adenocarcinoma(274;7.78e-05)		TCCCGCACATCCTTTGCTCTC	0.612		NaN											0	0	0	1	0	8	23				
ARHGEF12	23365	broad.mit.edu	37	11	120292558	120292558	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:120292558C>G	uc001pxl.1	+	6	352	c.345C>G	c.(343-345)ATC>ATG	p.I115M	ARHGEF12_uc009zat.2_Missense_Mutation_p.I96M|ARHGEF12_uc010rzn.1_Missense_Mutation_p.I12M|ARHGEF12_uc009zau.1_Missense_Mutation_p.I12M	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	115	PDZ.				apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		ATCGAATCATCAAGGTAAGGA	0.333		NaN	T	MLL	AML								0	0	0	1	0	12	52				
OR8G2	26492	broad.mit.edu	37	11	124096005	124096005	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:124096005C>T	uc010saf.1	+	1	608	c.608C>T	c.(607-609)TCC>TTC	p.S203F		NM_001007249	NP_001007250	Q15614	OR8G2_HUMAN	olfactory receptor, family 8, subfamily G,	203						integral to membrane	olfactory receptor activity				0		Breast(109;0.0157)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.91e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		CTCTCCTGCTCCAGCACCTAC	0.423		NaN											0	0	0	1	0	45	247				
APLP2	334	broad.mit.edu	37	11	129999042	129999042	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:129999042G>A	uc010sby.1	+	10	1553	c.1396G>A	c.(1396-1398)GAC>AAC	p.D466N	APLP2_uc001qfp.2_Missense_Mutation_p.D466N|APLP2_uc001qfq.2_Missense_Mutation_p.D410N|APLP2_uc010sbz.1_Missense_Mutation_p.D254N|APLP2_uc001qfr.2_Missense_Mutation_p.D232N|APLP2_uc001qfs.2_Missense_Mutation_p.D237N|APLP2_uc001qfv.2_Missense_Mutation_p.D357N	NM_001642	NP_001633	Q06481	APLP2_HUMAN	amyloid beta (A4) precursor-like protein 2	466	Extracellular (Potential).				G-protein coupled receptor protein signaling pathway	integral to membrane|nucleus|plasma membrane	DNA binding|identical protein binding|serine-type endopeptidase inhibitor activity			ovary(3)	3	all_hematologic(175;0.0429)	Breast(109;0.00586)|Lung NSC(97;0.00785)|all_lung(97;0.0154)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0197)|Lung(977;0.24)		TATGCTGAATGACCGCCGTCG	0.592		NaN											0	0	0	1	0	42	26				
KDM5A	5927	broad.mit.edu	37	12	442723	442723	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:442723G>C	uc001qif.1	-	12	1946	c.1583C>G	c.(1582-1584)TCC>TGC	p.S528C	KDM5A_uc001qie.1_Missense_Mutation_p.S528C|KDM5A_uc010sdn.1_Missense_Mutation_p.S487C|KDM5A_uc010sdo.1_Missense_Mutation_p.S147C	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	528	JmjC.				chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3						ATCAGGCTGGGATTCAAATAA	0.502		NaN	T 	NUP98	AML								0	0	0	1	0	22	45				
NOP2	4839	broad.mit.edu	37	12	6672897	6672897	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:6672897C>G	uc001qpk.1	-	6	615	c.571G>C	c.(571-573)GAG>CAG	p.E191Q	NOP2_uc009zeq.1_5'Flank|NOP2_uc001qph.1_Missense_Mutation_p.E187Q|NOP2_uc001qpi.1_Missense_Mutation_p.E187Q|NOP2_uc001qpj.1_Intron|NOP2_uc001qpl.1_Missense_Mutation_p.E224Q|NOP2_uc001qpm.1_Missense_Mutation_p.E191Q			P46087	NOP2_HUMAN	Homo sapiens cDNA FLJ31646 fis, clone NT2RI2003921, highly similar to PROLIFERATING-CELL NUCLEOLAR ANTIGEN P120.	191					positive regulation of cell proliferation|rRNA processing	nucleolus	protein binding|RNA binding|S-adenosylmethionine-dependent methyltransferase activity			ovary(2)	2						ACTTCTTTCTCTTCCTCCTCG	0.547		NaN									OREG0021630	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	4	25				
ING4	51147	broad.mit.edu	37	12	6761554	6761554	+	Silent	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:6761554G>C	uc001qpw.3	-	6	572	c.531C>G	c.(529-531)ACC>ACG	p.T177T	ING4_uc001qpv.3_Silent_p.T176T|ING4_uc001qpy.3_Silent_p.T173T|ING4_uc001qpx.3_Silent_p.T174T|ING4_uc009zes.2_Intron|ING4_uc009zet.2_Silent_p.T153T|ING4_uc009zeu.2_Intron|ING4_uc009zev.2_RNA	NM_001127582	NP_001121054	Q9UNL4	ING4_HUMAN	inhibitor of growth family, member 4 isoform 9	177					apoptosis|cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA replication|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation|negative regulation of cell proliferation|negative regulation of growth|negative regulation of transcription, DNA-dependent|positive regulation of apoptosis	histone acetyltransferase complex	protein binding|transcription coactivator activity|zinc ion binding			central_nervous_system(3)|ovary(1)	4						CACTGCCAAAGGTCACTGAGG	0.512		NaN											0	0	0	1	0	28	112				
A2M	2	broad.mit.edu	37	12	9229519	9229519	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:9229519C>T	uc001qvk.1	-	28	3478	c.3365G>A	c.(3364-3366)CGC>CAC	p.R1122H	A2M_uc001qvj.1_Missense_Mutation_p.R164H|A2M_uc009zgk.1_Missense_Mutation_p.R972H	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	1122					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	CAGGGCATTGCGGACAACAGG	0.502		NaN											0	0	0	1	0	31	63				
PZP	5858	broad.mit.edu	37	12	9305844	9305844	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:9305844C>T	uc001qvl.2	-	30	3899	c.3870G>A	c.(3868-3870)CAG>CAA	p.Q1290Q	PZP_uc009zgl.2_Silent_p.Q1076Q	NM_002864	NP_002855			pregnancy-zone protein precursor											ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)	5						TAGAAAAGGTCTGTGAATCCT	0.478		NaN											0	0	0	1	0	57	77				
LOH12CR1	118426	broad.mit.edu	37	12	12588569	12588569	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:12588569G>C	uc001ral.2	+	3	576	c.210G>C	c.(208-210)TTG>TTC	p.L70F	LOH12CR1_uc009zhu.2_Missense_Mutation_p.L22F	NM_058169	NP_477517	Q969J3	L12R1_HUMAN	LOH1CR12	70										ovary(1)	1		Prostate(47;0.0802)		BRCA - Breast invasive adenocarcinoma(232;0.0205)		AAGGGCTATTGAGTGGCCAGA	0.403		NaN											0	0	0	1	0	12	52				
LRMP	4033	broad.mit.edu	37	12	25260856	25260856	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:25260856G>C	uc001rgh.2	+	21	2396	c.1362G>C	c.(1360-1362)TTG>TTC	p.L454F	LRMP_uc010sja.1_Missense_Mutation_p.L454F|LRMP_uc010sjb.1_Missense_Mutation_p.L401F|LRMP_uc001rgi.2_RNA|LRMP_uc010sjc.1_Missense_Mutation_p.L454F|LRMP_uc010sjd.1_Missense_Mutation_p.L401F	NM_006152	NP_006143	Q12912	LRMP_HUMAN	lymphoid-restricted membrane protein	510	Helical; Anchor for type IV membrane protein; (Potential).				vesicle fusion|vesicle targeting	endoplasmic reticulum membrane|integral to plasma membrane				ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Colorectal(261;0.11)					TTGCAGCTTTGATGAGCTTCC	0.473		NaN											0	0	0	1	0	32	104				
RASSF8	11228	broad.mit.edu	37	12	26217937	26217937	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:26217937G>C	uc001rgx.2	+	3	831	c.610G>C	c.(610-612)GAG>CAG	p.E204Q	RASSF8_uc001rgy.2_Missense_Mutation_p.E204Q|RASSF8_uc001rgz.2_Missense_Mutation_p.E204Q|RASSF8_uc009zjd.1_Missense_Mutation_p.E204Q|RASSF8_uc009zje.1_Missense_Mutation_p.E204Q	NM_007211	NP_009142	Q8NHQ8	RASF8_HUMAN	Ras association (RalGDS/AF-6) domain family	204	Glu-rich.				signal transduction						0	Colorectal(261;0.0847)					CAACCTTGAAGAGGAAATTGT	0.363		NaN											0	0	0	1	0	7	58				
STK38L	23012	broad.mit.edu	37	12	27455101	27455101	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:27455101G>C	uc001rhr.2	+	3	365	c.166G>C	c.(166-168)GAA>CAA	p.E56Q	STK38L_uc001rhs.2_RNA|STK38L_uc010sjm.1_Missense_Mutation_p.E4Q	NM_015000	NP_055815	Q9Y2H1	ST38L_HUMAN	serine/threonine kinase 38 like	56					intracellular protein kinase cascade|regulation of cellular component organization	actin cytoskeleton|cytoplasm	actin binding|ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|kidney(1)	5	Colorectal(261;0.0847)					CATGGAAGAAGAAGGATTAGC	0.299		NaN											0	0	0	1	0	47	72				
PPFIBP1	8496	broad.mit.edu	37	12	27788022	27788022	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:27788022C>G	uc001ric.1	+	4	621	c.244C>G	c.(244-246)CTT>GTT	p.L82V	PPFIBP1_uc001rhy.1_Missense_Mutation_p.L82V|PPFIBP1_uc001rhz.1_Missense_Mutation_p.L82V|PPFIBP1_uc010sjr.1_Intron|PPFIBP1_uc001rib.1_Missense_Mutation_p.L82V|PPFIBP1_uc001ria.2_Missense_Mutation_p.L82V|PPFIBP1_uc001rid.1_Intron	NM_003622	NP_003613	Q86W92	LIPB1_HUMAN	PTPRF interacting protein binding protein 1	82					cell adhesion	plasma membrane	protein binding		PPFIBP1/ALK(3)	soft_tissue(3)|kidney(1)|skin(1)	5	Lung SC(9;0.0873)					AGCAGAAACGCTTGTTGAATG	0.413		NaN											0	0	0	1	0	23	53				
IRAK4	51135	broad.mit.edu	37	12	44180267	44180267	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:44180267G>C	uc001rnu.3	+	12	1384	c.1254G>C	c.(1252-1254)ATG>ATC	p.M418I	IRAK4_uc001rnt.3_Missense_Mutation_p.M418I|IRAK4_uc001rnx.3_Missense_Mutation_p.M294I|IRAK4_uc001rny.3_Missense_Mutation_p.M294I|IRAK4_uc010sky.1_Missense_Mutation_p.M294I|IRAK4_uc001rnv.3_Missense_Mutation_p.M294I|IRAK4_uc001rnw.3_Missense_Mutation_p.M294I	NM_001114182	NP_001107654	Q9NWZ3	IRAK4_HUMAN	interleukin-1 receptor-associated kinase 4	418	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity				0	all_cancers(12;0.00149)	Lung NSC(34;0.0804)|all_lung(34;0.181)		GBM - Glioblastoma multiforme(48;0.04)		ATAAAAAGATGAATGATGCTG	0.303		NaN											0	0	0	1	0	18	75				
SLC38A2	54407	broad.mit.edu	37	12	46764968	46764968	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:46764968G>A	uc001rpg.2	-	2	549	c.109C>T	c.(109-111)CTG>TTG	p.L37L	SLC38A2_uc001rph.2_5'UTR	NM_018976	NP_061849	Q96QD8	S38A2_HUMAN	solute carrier family 38, member 2	37	Cytoplasmic (Potential).|Regulates protein turnover upon amino acid deprivation (By similarity).				cellular nitrogen compound metabolic process|glutamate secretion|neurotransmitter secretion|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			urinary_tract(1)|skin(1)	2	Lung SC(27;0.192)|Renal(347;0.236)		OV - Ovarian serous cystadenocarcinoma(5;0.0048)|Epithelial(2;0.0374)	GBM - Glioblastoma multiforme(48;0.226)		CACCTTTTCAGAGCAGCTTGC	0.488		NaN											0	0	0	1	0	8	127				
AMIGO2	347902	broad.mit.edu	37	12	47472633	47472633	+	Silent	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:47472633G>T	uc001rpm.2	-	3	808	c.153C>A	c.(151-153)ATC>ATA	p.I51I	FAM113B_uc001rpn.2_5'Flank|AMIGO2_uc001rpk.2_Silent_p.I51I|AMIGO2_uc001rpl.2_Silent_p.I51I	NM_001143668	NP_001137140	Q86SJ2	AMGO2_HUMAN	adhesion molecule with Ig-like domain 2	51	Extracellular (Potential).|LRRNT.				heterophilic cell-cell adhesion|homophilic cell adhesion	integral to membrane|nucleus|plasma membrane				ovary(1)|skin(1)	2	Renal(347;0.138)|Lung SC(27;0.192)					TGCAGCTGACGATGTCAGTGG	0.542		NaN											1	0	1.56442e-22	1	1.75029e-22	33	62				
DDX23	9416	broad.mit.edu	37	12	49226345	49226345	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:49226345G>A	uc001rsm.2	-	14	1906	c.1815C>T	c.(1813-1815)TTC>TTT	p.F605F		NM_004818	NP_004809	Q9BUQ8	DDX23_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23	605	Helicase ATP-binding.					catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent RNA helicase activity|nucleic acid binding|protein binding			kidney(3)|ovary(1)|lung(1)|skin(1)	6						TGGTGGCCGTGAACATGACTG	0.587		NaN											0	0	0	1	0	9	41				
MLL2	8085	broad.mit.edu	37	12	49424126	49424126	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:49424126C>T	uc001rta.3	-	42	13936	c.13936G>A	c.(13936-13938)GAA>AAA	p.E4646K		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	4646					chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						CCCAGCTCTTCAGATGGGGTG	0.612		NaN	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	1	0	5	6		Valid		
NCKAP5L	57701	broad.mit.edu	37	12	50195682	50195682	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:50195682C>T	uc009zlk.2	-	6	502	c.300G>A	c.(298-300)CTG>CTA	p.L100L		NM_001037806	NP_001032895	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	96	Potential.									central_nervous_system(1)	1						ACAGGGCACTCAGCATCTGGT	0.592		NaN											0	0	0	1	0	15	66				
LIMA1	51474	broad.mit.edu	37	12	50598415	50598415	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:50598415G>C	uc001rwj.3	-	6	958	c.784C>G	c.(784-786)CTC>GTC	p.L262V	LIMA1_uc001rwg.3_5'Flank|LIMA1_uc001rwh.3_Missense_Mutation_p.L102V|LIMA1_uc001rwi.3_Missense_Mutation_p.L102V|LIMA1_uc001rwk.3_Missense_Mutation_p.L262V|LIMA1_uc010smr.1_RNA|LIMA1_uc010sms.1_RNA	NM_016357	NP_057441	Q9UHB6	LIMA1_HUMAN	LIM domain and actin binding 1 isoform b	262					actin filament bundle assembly|negative regulation of actin filament depolymerization|ruffle organization	cytoplasm|focal adhesion|stress fiber	actin filament binding|actin monomer binding|zinc ion binding			ovary(1)	1						GTTTCTGAGAGGCGTGGAAGT	0.403		NaN											0	0	0	1	0	54	62				
KRT84	3890	broad.mit.edu	37	12	52774948	52774948	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:52774948G>A	uc001sah.1	-	6	1167	c.1119C>T	c.(1117-1119)AAC>AAT	p.N373N		NM_033045	NP_149034	Q9NSB2	KRT84_HUMAN	keratin, hair, basic, 4	373	Rod.|Coil 2.					keratin filament	structural constituent of epidermis			skin(1)	1	all_hematologic(5;0.12)			BRCA - Breast invasive adenocarcinoma(357;0.189)		TGTTGCGCAGGTTGTCACAGT	0.557		NaN											0	0	0	1	0	40	144				
KRT84	3890	broad.mit.edu	37	12	52776813	52776813	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:52776813C>G	uc001sah.1	-	3	840	c.792G>C	c.(790-792)GAG>GAC	p.E264D		NM_033045	NP_149034	Q9NSB2	KRT84_HUMAN	keratin, hair, basic, 4	264	Rod.|Coil 1B.					keratin filament	structural constituent of epidermis			skin(1)	1	all_hematologic(5;0.12)			BRCA - Breast invasive adenocarcinoma(357;0.189)		CAAACTCATTCTCAGCATTGG	0.502		NaN											0	0	0	1	0	18	59				
KRT4	3851	broad.mit.edu	37	12	53204577	53204577	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:53204577C>T	uc001saz.2	-	3	1194	c.923G>A	c.(922-924)CGC>CAC	p.R308H		NM_002272	NP_002263	B4DRS2	B4DRS2_HUMAN	keratin 4	234						keratin filament	structural molecule activity			ovary(4)|skin(2)	6						GGCTGCTGTGCGTTTGTTGAT	0.517		NaN											0	0	0	1	0	16	53				
SP7	121340	broad.mit.edu	37	12	53723022	53723022	+	Missense_Mutation	SNP	A	A	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:53723022A>T	uc001sct.2	-	2	311	c.204T>A	c.(202-204)TTT>TTA	p.F68L	SP7_uc001scu.2_Missense_Mutation_p.F50L|SP7_uc001scv.2_Missense_Mutation_p.F68L	NM_152860	NP_690599	Q8TDD2	SP7_HUMAN	osterix	68					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TAGTGCTTGTAAAGGGGGCTG	0.542		NaN											0	0	0	1	0	30	139				
ATF7	11016	broad.mit.edu	37	12	53918472	53918472	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:53918472C>T	uc001sdy.2	-	9	1055	c.1034G>A	c.(1033-1035)CGA>CAA	p.R345Q	ATF7_uc010sok.1_RNA|ATF7_uc001sdz.2_Missense_Mutation_p.R334Q|ATF7_uc010sol.1_Missense_Mutation_p.R313Q	NM_001130059	NP_001123531	P17544	ATF7_HUMAN	activating transcription factor 7 isoform 1	345	Basic motif.|Essential for binding adenovirus 2 E1A.				interspecies interaction between organisms	cytoplasm|nuclear periphery|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)	2						GCGCTGCCGTCGCTCATCTGG	0.622		NaN											0	0	0	1	0	8	23				
DNAJC14	85406	broad.mit.edu	37	12	56188173	56188173	+	Splice_Site	SNP	T	T	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:56188173T>C	uc001shu.1	-	12	2483	c.2427_splice	c.e12-1	p.R809_splice	SARNP_uc009zoa.2_Splice_Site|SARNP_uc001shs.3_Splice_Site|SARNP_uc001sht.2_Splice_Site_p.R126_splice|SARNP_uc001shv.3_Intron	NM_032364	NP_115740	Q6Y2X3	DJC14_HUMAN	dopamine receptor interacting protein						protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			ovary(3)|large_intestine(1)	4						ATCCCAAACCTGAAGAAGGAA	0.358		NaN											0	0	0	1	0	69	234				
DNAJC14	85406	broad.mit.edu	37	12	56215880	56215880	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:56215880A>G	uc001shx.1	-	7	2194	c.1990T>C	c.(1990-1992)TTT>CTT	p.F664L	DNAJC14_uc001shu.1_Missense_Mutation_p.F664L|DNAJC14_uc009zob.1_Missense_Mutation_p.F664L	NM_032364	NP_115740	Q6Y2X3	DJC14_HUMAN	dopamine receptor interacting protein	664					protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			ovary(3)|large_intestine(1)	4						GGAGCTGCAAAGAAGTTCCCA	0.567		NaN											0	0	0	1	0	20	56				
SILV	6490	broad.mit.edu	37	12	56351734	56351734	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:56351734G>C	uc001sip.2	-	5	635	c.604C>G	c.(604-606)CAT>GAT	p.H202D	SILV_uc001siq.2_Missense_Mutation_p.H202D|SILV_uc010spx.1_Missense_Mutation_p.H116D|SILV_uc001sir.2_Missense_Mutation_p.H202D	NM_006928	NP_008859	P40967	PMEL_HUMAN	silver homolog	202					melanin biosynthetic process|melanosome organization	endoplasmic reticulum membrane|extracellular region|Golgi apparatus|integral to membrane|melanosome|multivesicular body membrane|plasma membrane	protein binding				0						GAGCTGGAATGAGCAAGAGGC	0.572		NaN											0	0	0	1	0	31	50				
SILV	6490	broad.mit.edu	37	12	56351767	56351767	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:56351767G>A	uc001sip.2	-	5	602	c.571C>T	c.(571-573)CGC>TGC	p.R191C	SILV_uc001siq.2_Missense_Mutation_p.R191C|SILV_uc010spx.1_Missense_Mutation_p.R105C|SILV_uc001sir.2_Missense_Mutation_p.R191C	NM_006928	NP_008859	P40967	PMEL_HUMAN	silver homolog	191					melanin biosynthetic process|melanosome organization	endoplasmic reticulum membrane|extracellular region|Golgi apparatus|integral to membrane|melanosome|multivesicular body membrane|plasma membrane	protein binding				0						GATCCCCGGCGATGGTAGACA	0.572		NaN											0	0	0	1	0	27	48				
SMARCC2	6601	broad.mit.edu	37	12	56565672	56565672	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:56565672C>T	uc001skb.2	-	20	1989	c.1883G>A	c.(1882-1884)GGA>GAA	p.G628E	SMARCC2_uc001skd.2_Missense_Mutation_p.G659E|SMARCC2_uc001ska.2_Missense_Mutation_p.G659E|SMARCC2_uc001skc.2_Missense_Mutation_p.G658E|SMARCC2_uc010sqf.1_Missense_Mutation_p.G548E	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	628	SANT.				chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)			TGTGCGGCTTCCCACATGCTC	0.527		NaN											0	0	0	1	0	22	25		Valid		
TIMELESS	8914	broad.mit.edu	37	12	56817644	56817644	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:56817644G>C	uc001slf.2	-	16	2071	c.1903C>G	c.(1903-1905)CAA>GAA	p.Q635E		NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	635					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						GAAATGTCTTGAGAGCCAAAC	0.473		NaN											0	0	0	1	0	32	52				
TIMELESS	8914	broad.mit.edu	37	12	56818562	56818562	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:56818562G>C	uc001slf.2	-	15	2020	c.1852C>G	c.(1852-1854)CTC>GTC	p.L618V		NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	618					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						GACCTCAGGAGAGTCAGGGCC	0.597		NaN											0	0	0	1	0	38	57				
DPY19L2	283417	broad.mit.edu	37	12	64061860	64061860	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:64061860G>C	uc001srp.1	-	1	495	c.314C>G	c.(313-315)TCC>TGC	p.S105C	DPY19L2_uc009zqk.1_RNA	NM_173812	NP_776173	Q6NUT2	D19L2_HUMAN	dpy-19-like 2	105					multicellular organismal development|spermatid development	integral to membrane				central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		GGTTCTGCTGGAGAACCGCCG	0.592		NaN											0	0	0	1	0	45	51				
HELB	92797	broad.mit.edu	37	12	66698778	66698778	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:66698778C>G	uc001sti.2	+	2	483	c.455C>G	c.(454-456)TCA>TGA	p.S152*	HELB_uc010ssz.1_RNA|HELB_uc009zqt.1_RNA	NM_033647	NP_387467	Q8NG08	HELB_HUMAN	helicase (DNA) B	152					DNA replication, synthesis of RNA primer		ATP binding|ATP-dependent 5'-3' DNA helicase activity|single-stranded DNA-dependent ATP-dependent DNA helicase activity			central_nervous_system(1)|pancreas(1)	2			GBM - Glioblastoma multiforme(2;0.000142)	GBM - Glioblastoma multiforme(28;0.0265)		AAGGAGGTATCAAACTACAAA	0.358		NaN											0	0	0	1	0	22	48				
CCT2	10576	broad.mit.edu	37	12	69991012	69991012	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:69991012G>T	uc001svb.1	+	11	1153	c.1059G>T	c.(1057-1059)ATG>ATT	p.M353I	CCT2_uc009zrm.1_RNA|CCT2_uc009zrn.1_Missense_Mutation_p.M353I|CCT2_uc010stl.1_Missense_Mutation_p.M306I	NM_006431	NP_006422	P78371	TCPB_HUMAN	chaperonin containing TCP1, subunit 2	353					'de novo' posttranslational protein folding	nucleus	ATP binding|unfolded protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(2;7.7e-106)|Breast(13;2.15e-06)|Esophageal squamous(21;0.187)		Epithelial(6;2.72e-18)|GBM - Glioblastoma multiforme(2;2.58e-10)|Lung(24;0.000185)|OV - Ovarian serous cystadenocarcinoma(12;0.00126)|STAD - Stomach adenocarcinoma(21;0.00501)|Kidney(9;0.143)|LUSC - Lung squamous cell carcinoma(43;0.24)			AGGAAGTCATGATTGGAGAAG	0.413		NaN											1	0	7.63117e-38	1	8.63282e-38	83	108				
ZFC3H1	196441	broad.mit.edu	37	12	72017272	72017272	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:72017272G>C	uc001swo.2	-	24	4971	c.4612C>G	c.(4612-4614)CTC>GTC	p.L1538V		NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	1538					RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						TTTGAAGGGAGAATGTTGAAT	0.343		NaN											0	0	0	1	0	7	119				
BBS10	79738	broad.mit.edu	37	12	76740913	76740913	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:76740913C>G	uc001syd.1	-	2	936	c.852G>C	c.(850-852)CAG>CAC	p.Q284H		NM_024685	NP_078961	Q8TAM1	BBS10_HUMAN	Bardet-Biedl syndrome 10	284					cellular protein metabolic process|nonmotile primary cilium assembly|photoreceptor cell maintenance|response to stimulus|retina homeostasis	cilium	ATP binding			ovary(1)|skin(1)	2						ATTGAGATGTCTGAAACTGTG	0.348		NaN							Bardet-Biedl_syndrome				0	0	0	1	0	16	20				
SYT1	6857	broad.mit.edu	37	12	79837968	79837968	+	Silent	SNP	A	A	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:79837968A>C	uc001sys.2	+	11	1715	c.1044A>C	c.(1042-1044)GTA>GTC	p.V348V	SYT1_uc001syt.2_Silent_p.V348V|SYT1_uc001syu.2_Silent_p.V345V|SYT1_uc001syv.2_Silent_p.V348V	NM_001135805	NP_001129277	P21579	SYT1_HUMAN	synaptotagmin I	348	Cytoplasmic (Potential).|Phospholipid binding (Probable).|C2 2.				detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			skin(3)|pancreas(2)|ovary(1)	6						GCTTTGAAGTACCTTTTGAAC	0.353		NaN											0	0	0	1	0	27	183				
PPP1R12A	4659	broad.mit.edu	37	12	80266706	80266706	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:80266706C>G	uc001syz.2	-	2	517	c.250G>C	c.(250-252)GAC>CAC	p.D84H	PPP1R12A_uc010suc.1_5'UTR|PPP1R12A_uc001sza.2_Missense_Mutation_p.D84H|PPP1R12A_uc010sud.1_Missense_Mutation_p.D84H|PPP1R12A_uc001szb.2_Missense_Mutation_p.D84H|PPP1R12A_uc001szc.2_Missense_Mutation_p.D84H	NM_002480	NP_002471	O14974	MYPT1_HUMAN	protein phosphatase 1, regulatory (inhibitor)	84	ANK 2.					contractile fiber	protein binding|signal transducer activity			ovary(2)|breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	7						TCAACATTGTCATCAATGCAA	0.343		NaN											0	0	0	1	0	4	30				
ACSS3	79611	broad.mit.edu	37	12	81647169	81647169	+	Silent	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:81647169C>G	uc001szl.1	+	14	1894	c.1803C>G	c.(1801-1803)CTC>CTG	p.L601L	ACSS3_uc001szm.1_Silent_p.L600L|ACSS3_uc001szn.1_Silent_p.L283L	NM_024560	NP_078836	Q9H6R3	ACSS3_HUMAN	acyl-CoA synthetase short-chain family member 3	601						mitochondrion	acetate-CoA ligase activity|ATP binding			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4						CCTTAGCACTCTGTGTATTGA	0.428		NaN											0	0	0	1	0	37	161				
LRRIQ1	84125	broad.mit.edu	37	12	85449499	85449499	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:85449499C>A	uc001tac.2	+	8	1039	c.928C>A	c.(928-930)CAA>AAA	p.Q310K	LRRIQ1_uc001tab.1_Missense_Mutation_p.Q310K|LRRIQ1_uc001taa.1_Missense_Mutation_p.Q285K	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	310	IQ 1.|Glu-rich.									ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		TATTAAAGAGCAAATTGAAAG	0.154		NaN											1	0	5.9392e-07	1	6.22056e-07	6	35				
LRRIQ1	84125	broad.mit.edu	37	12	85517896	85517896	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:85517896G>A	uc001tac.2	+	17	3717	c.3606G>A	c.(3604-3606)AAG>AAA	p.K1202K	LRRIQ1_uc001tab.1_Silent_p.K1202K	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	1202										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		ATTATTTTAAGAAATTGATGA	0.333		NaN											0	0	0	1	0	12	54				
MGAT4C	25834	broad.mit.edu	37	12	86374166	86374166	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:86374166C>A	uc001tai.3	-	8	1588	c.338G>T	c.(337-339)GGA>GTA	p.G113V	MGAT4C_uc001tal.3_Missense_Mutation_p.G113V|MGAT4C_uc001taj.3_Missense_Mutation_p.G113V|MGAT4C_uc001tak.3_Missense_Mutation_p.G113V|MGAT4C_uc010sum.1_Missense_Mutation_p.G137V|MGAT4C_uc001tah.3_Missense_Mutation_p.G113V	NM_013244	NP_037376	Q9UBM8	MGT4C_HUMAN	alpha-1,3-mannosyl-glycoprotein	113	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity|metal ion binding			ovary(3)	3						TAAATAGTTTCCTTTTTTTCG	0.328		NaN											1	0	8.34094e-07	1	8.70917e-07	21	21				
NEDD1	121441	broad.mit.edu	37	12	97331111	97331111	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:97331111C>G	uc001teu.3	+	9	1396	c.1057C>G	c.(1057-1059)CTA>GTA	p.L353V	NEDD1_uc001tev.3_Missense_Mutation_p.L353V|NEDD1_uc010svc.1_Missense_Mutation_p.L264V|NEDD1_uc001tew.2_Missense_Mutation_p.L360V|NEDD1_uc001tex.2_Missense_Mutation_p.L264V	NM_152905	NP_690869	Q8NHV4	NEDD1_HUMAN	neural precursor cell expressed, developmentally	353					cell division|G2/M transition of mitotic cell cycle|mitosis	cytosol					0						TGCCACAGTTCTACCACAACC	0.428		NaN											0	0	0	1	0	20	114				
UTP20	27340	broad.mit.edu	37	12	101776903	101776903	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:101776903G>C	uc001tia.1	+	59	7897	c.7741G>C	c.(7741-7743)GAC>CAC	p.D2581H		NM_014503	NP_055318	O75691	UTP20_HUMAN	down-regulated in metastasis	2581					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			ovary(2)|breast(2)	4						GATAAAAGAAGACCTGGAAGA	0.418		NaN											0	0	0	1	0	21	31				
CCDC53	51019	broad.mit.edu	37	12	102433677	102433677	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:102433677C>A	uc010svw.1	-	5	563	c.404G>T	c.(403-405)AGA>ATA	p.R135I	CCDC53_uc010svx.1_RNA|CCDC53_uc010svy.1_RNA|CCDC53_uc010svz.1_Missense_Mutation_p.R134I	NM_016053	NP_057137	Q9Y3C0	CCD53_HUMAN	coiled-coil domain containing 53	135						WASH complex	protein binding				0						TCTGGCATATCTTGGATCCTT	0.403		NaN											1	0	8.72158e-25	1	9.81178e-25	60	67				
STAB2	55576	broad.mit.edu	37	12	104049332	104049332	+	Silent	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:104049332C>A	uc001tjw.2	+	15	1893	c.1707C>A	c.(1705-1707)GGC>GGA	p.G569G		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	569	Extracellular (Potential).|FAS1 2.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						TGAAGGACGGCACTCTCGATT	0.453		NaN											1	0	1.5842e-08	1	1.67477e-08	13	40				
STAB2	55576	broad.mit.edu	37	12	104142822	104142822	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:104142822G>A	uc001tjw.2	+	59	6512	c.6326G>A	c.(6325-6327)AGC>AAC	p.S2109N	STAB2_uc009zug.2_RNA	NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	2109	Extracellular (Potential).|EGF-like 16.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						GTCTCCTGCAGCTGCCAGAAG	0.587		NaN											0	0	0	1	0	22	62				
RIC8B	55188	broad.mit.edu	37	12	107209010	107209010	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:107209010G>C	uc001tlx.2	+	3	794	c.669G>C	c.(667-669)GAG>GAC	p.E223D	RIC8B_uc001tlw.2_Missense_Mutation_p.E223D|RIC8B_uc001tly.2_Missense_Mutation_p.E183D|RIC8B_uc001tlz.2_RNA	NM_018157	NP_060627	Q9NVN3	RIC8B_HUMAN	resistance to inhibitors of cholinesterase 8	223					regulation of G-protein coupled receptor protein signaling pathway	cell cortex|cytosol|plasma membrane	G-protein alpha-subunit binding|guanyl-nucleotide exchange factor activity			ovary(1)	1						CACCTCAGGAGACAGACTGTG	0.478		NaN											0	0	0	1	0	47	72				
WSCD2	9671	broad.mit.edu	37	12	108603968	108603968	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:108603968G>T	uc001tms.2	+	4	1312	c.568G>T	c.(568-570)GTG>TTG	p.V190L	WSCD2_uc001tmt.2_Missense_Mutation_p.V190L	NM_014653	NP_055468	Q2TBF2	WSCD2_HUMAN	WSC domain containing 2	190	WSC 1.					integral to membrane				ovary(1)|large_intestine(1)|breast(1)	3						GGCGACGAACGTGAGCGAGGC	0.672		NaN											1	0	0.115264	1	0.115264	3	24				
WSB2	55884	broad.mit.edu	37	12	118476129	118476129	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:118476129G>C	uc001twr.2	-	5	722	c.624C>G	c.(622-624)GAC>GAG	p.D208E	WSB2_uc010sza.1_Intron|WSB2_uc010szb.1_5'UTR|WSB2_uc009zws.1_Missense_Mutation_p.D208E	NM_018639	NP_061109	Q9NYS7	WSB2_HUMAN	WD SOCS-box protein 2	208	WD 3.				intracellular signal transduction					ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GCATGCTGCAGTCTGGGGAGA	0.512		NaN											0	0	0	1	0	14	25				
SRRM4	84530	broad.mit.edu	37	12	119559877	119559877	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:119559877C>A	uc001txa.1	+	6	759	c.467C>A	c.(466-468)TCC>TAC	p.S156Y		NM_194286	NP_919262	A7MD48	SRRM4_HUMAN	KIAA1853 protein	156	Ser-rich.|Lys-rich.				cell differentiation|mRNA processing|nervous system development|regulation of RNA splicing|RNA splicing	nucleus	mRNA binding			ovary(2)	2						TTGTTTAGCTCCTCTAGCCCA	0.378		NaN											1	0	0.000151284	1	0.000155097	12	28				
GCN1L1	10985	broad.mit.edu	37	12	120576567	120576567	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:120576567C>T	uc001txo.2	-	46	6101	c.6088G>A	c.(6088-6090)GAG>AAG	p.E2030K		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	2030	HEAT 17.				regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TGCAGCTGCTCGAAAGTCTTG	0.547		NaN											0	0	0	1	0	28	102				
PLA2G1B	5319	broad.mit.edu	37	12	120759997	120759997	+	Nonstop_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:120759997C>A	uc001tyd.2	-	4	482	c.446G>T	c.(445-447)TGA>TTA	p.*149L	PLA2G1B_uc009zwx.2_3'UTR	NM_000928	NP_000919	P04054	PA21B_HUMAN	phospholipase A2 group IB precursor	149					actin filament organization|activation of MAPK activity|activation of phospholipase A2 activity|arachidonic acid secretion|cellular response to insulin stimulus|glucose transport|interleukin-8 production|leukotriene biosynthetic process|multicellular organismal lipid catabolic process|neutrophil chemotaxis|neutrophil mediated immunity|phosphatidylcholine metabolic process|positive regulation of calcium ion transport into cytosol|positive regulation of DNA replication|positive regulation of immune response|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein secretion|positive regulation of transcription from RNA polymerase II promoter	extracellular space	bile acid binding|calcium ion binding|calcium-dependent phospholipase A2 activity|cell surface binding|receptor binding			skin(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AGGTGATATTCAACTCTGACA	0.423		NaN											1	0	7.82978e-24	1	8.78906e-24	62	181				
POP5	51367	broad.mit.edu	37	12	121018922	121018922	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:121018922G>A	uc001tys.2	-	2	191	c.159C>T	c.(157-159)TTC>TTT	p.F53F	POP5_uc001tyt.2_Silent_p.F53F	NM_015918	NP_057002	Q969H6	POP5_HUMAN	processing of precursor 5 isoform a	53					tRNA processing		protein binding|ribonuclease P activity				0	all_neural(191;0.077)|Medulloblastoma(191;0.0922)					TTGCACCCGCGAAGCCGATGG	0.677		NaN											0	0	0	1	0	11	61				
WDR66	144406	broad.mit.edu	37	12	122392093	122392093	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:122392093C>T	uc009zxk.2	+	10	1530	c.1388C>T	c.(1387-1389)TCA>TTA	p.S463L		NM_144668	NP_653269	Q8TBY9	WDR66_HUMAN	WD repeat domain 66	463	WD 4.						calcium ion binding			ovary(1)|skin(1)	2	all_neural(191;0.0496)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;0.000155)|Epithelial(86;0.000634)|BRCA - Breast invasive adenocarcinoma(302;0.248)		CAAATACTCTCAGCCACAATG	0.438		NaN											0	0	0	1	0	36	69				
VPS33A	65082	broad.mit.edu	37	12	122750907	122750907	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:122750907C>T	uc001ucd.2	-	1	162	c.49G>A	c.(49-51)GAG>AAG	p.E17K	VPS33A_uc001ucc.2_RNA|VPS33A_uc001uce.2_Missense_Mutation_p.E17K	NM_022916	NP_075067	Q96AX1	VP33A_HUMAN	vacuolar protein sorting 33A	17					lysosome localization|melanosome localization|platelet formation|protein transport|regulation of developmental pigmentation|vesicle docking involved in exocytosis	early endosome|late endosome membrane|lysosomal membrane|perinuclear region of cytoplasm	protein binding			skin(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000336)|Epithelial(86;0.000606)|BRCA - Breast invasive adenocarcinoma(302;0.23)		CGCACCGCCTCGCGCAACACG	0.677		NaN											0	0	0	1	0	8	36				
CLIP1	6249	broad.mit.edu	37	12	122825453	122825453	+	Silent	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:122825453G>C	uc001ucg.1	-	10	2404	c.2298C>G	c.(2296-2298)CTC>CTG	p.L766L	CLIP1_uc001uch.1_Silent_p.L755L|CLIP1_uc001uci.1_Silent_p.L720L|CLIP1_uc001ucj.1_Intron	NM_002956	NP_002947	P30622	CLIP1_HUMAN	restin isoform a	766	Potential.			L -> P (in Ref. 3; AAI14214).	mitotic prometaphase|positive regulation of microtubule polymerization	centrosome|cytosol|endosome|intermediate filament|kinetochore	nucleic acid binding|protein homodimerization activity|zinc ion binding			ovary(2)|breast(1)	3	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.81e-05)|Epithelial(86;6.85e-05)|BRCA - Breast invasive adenocarcinoma(302;0.226)		CAGTAGCCTTGAGCTGTGATG	0.408		NaN											0	0	0	1	0	52	108				
DNAH10	196385	broad.mit.edu	37	12	124315201	124315201	+	Silent	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:124315201C>A	uc001uft.3	+	25	4171	c.4146C>A	c.(4144-4146)CTC>CTA	p.L1382L		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	1382	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		CAGATGTTCTCAATGAGATTG	0.368		NaN											1	0	7.93312e-07	1	8.29186e-07	13	19				
SCARB1	949	broad.mit.edu	37	12	125284769	125284769	+	Silent	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr12:125284769G>T	uc001ugo.3	-	8	1282	c.1029C>A	c.(1027-1029)TCC>TCA	p.S343S	SCARB1_uc001ugn.3_Silent_p.S343S|SCARB1_uc001ugm.3_Silent_p.S343S|SCARB1_uc010tbd.1_Silent_p.S343S|SCARB1_uc010tbe.1_Silent_p.S302S|SCARB1_uc001ugp.3_Silent_p.S343S	NM_005505	NP_005496	Q8WTV0	SCRB1_HUMAN	scavenger receptor class B, member 1 isoform 1	343	Extracellular (Potential).				adhesion to symbiont|cell adhesion|cholesterol efflux|cholesterol homeostasis|cholesterol import|detection of lipopolysaccharide|high-density lipoprotein particle clearance|high-density lipoprotein particle remodeling|lipopolysaccharide transport|lipoprotein metabolic process|positive regulation of cholesterol storage|positive regulation of endothelial cell migration|positive regulation of nitric-oxide synthase activity|recognition of apoptotic cell|reverse cholesterol transport|triglyceride homeostasis|wound healing	caveola	1-phosphatidylinositol binding|apolipoprotein A-I binding|high-density lipoprotein particle receptor activity|lipopolysaccharide receptor activity|low-density lipoprotein particle binding|phosphatidylserine binding|transporter activity			kidney(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000116)|Epithelial(86;0.000415)|all cancers(50;0.00395)	Phosphatidylserine(DB00144)	AGTGAGGATGGGAGAGAAACA	0.602		NaN											1	0	5.16669e-11	1	5.56034e-11	11	32				
TPTE2	93492	broad.mit.edu	37	13	20006667	20006667	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr13:20006667G>C	uc001umd.2	-	17	1379	c.1168C>G	c.(1168-1170)CTC>GTC	p.L390V	TPTE2_uc009zzk.2_RNA|TPTE2_uc009zzl.2_Missense_Mutation_p.L279V|TPTE2_uc001ume.2_Missense_Mutation_p.L313V|TPTE2_uc009zzm.2_Missense_Mutation_p.L61V|TPTE2_uc010tcm.1_RNA|TPTE2_uc010tcl.1_Missense_Mutation_p.L61V	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid	390						endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		CTTGGAGGGAGATTCCAGTTG	0.358		NaN											0	0	0	1	0	6	24				
SACS	26278	broad.mit.edu	37	13	23930039	23930039	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr13:23930039T>C	uc001uon.2	-	8	1301	c.712A>G	c.(712-714)AAA>GAA	p.K238E	SACS_uc001uoo.2_Missense_Mutation_p.K91E|SACS_uc001uop.1_Missense_Mutation_p.K25E|SACS_uc001uoq.1_Missense_Mutation_p.K91E	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	238					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CTAATTTCTTTGCTGTCATCT	0.388		NaN											0	0	0	1	0	63	3				
FAM123A	219287	broad.mit.edu	37	13	25745097	25745097	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr13:25745097C>T	uc001uqb.2	-	1	761	c.661G>A	c.(661-663)GGG>AGG	p.G221R	FAM123A_uc001uqa.2_Missense_Mutation_p.G221R|FAM123A_uc001uqc.2_Missense_Mutation_p.G221R	NM_152704	NP_689917	Q8N7J2	F123A_HUMAN	hypothetical protein LOC219287 isoform 1	221										ovary(2)|large_intestine(1)|lung(1)	4		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.0071)|Epithelial(112;0.0398)|OV - Ovarian serous cystadenocarcinoma(117;0.151)|GBM - Glioblastoma multiforme(144;0.222)|Lung(94;0.241)		AAgccgcccccgggcgcgcgc	0.582		NaN											0	0	0	1	0	7	1				
KBTBD7	84078	broad.mit.edu	37	13	41766848	41766848	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr13:41766848G>A	uc001uxw.1	-	1	1855	c.1546C>T	c.(1546-1548)CAG>TAG	p.Q516*	uc001uxv.1_Intron	NM_032138	NP_115514	Q8WVZ9	KBTB7_HUMAN	kelch repeat and BTB (POZ) domain containing 7	516	Kelch 3.						protein binding			ovary(1)	1		Lung NSC(96;0.000105)|Breast(139;0.00715)|Prostate(109;0.0233)|Lung SC(185;0.0367)		all cancers(112;6.21e-09)|Epithelial(112;6.99e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000196)|GBM - Glioblastoma multiforme(144;0.000857)|BRCA - Breast invasive adenocarcinoma(63;0.0669)		CATGCTTCCTGAAAGTCACTA	0.428		NaN											0	0	0	1	0	82	11				
C13orf18	80183	broad.mit.edu	37	13	46946326	46946326	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr13:46946326G>A	uc010acl.2	-	3	890	c.285C>T	c.(283-285)CTC>CTT	p.L95L	C13orf18_uc001vbf.3_Silent_p.L28L|C13orf18_uc001vbg.3_5'UTR|C13orf18_uc010tfz.1_Intron|C13orf18_uc010acm.2_5'UTR|C13orf18_uc010acn.2_Intron|C13orf18_uc001vbe.3_Silent_p.L95L|C13orf18_uc001vbh.3_Silent_p.L95L|C13orf18_uc001vbi.3_Intron|C13orf18_uc010aco.1_Silent_p.L95L|C13orf18_uc010tga.1_Silent_p.L28L	NM_025113	NP_079389	Q9H714	CM018_HUMAN	hypothetical protein LOC80183	95	Ser-rich.										0		Lung NSC(96;2.31e-05)|Breast(56;8.04e-05)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;2.19e-05)		GGGAGTCCCCGAGGCACGAAG	0.582		NaN											0	0	0	1	0	12	35				
PCDH17	27253	broad.mit.edu	37	13	58207298	58207298	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr13:58207298G>A	uc001vhq.1	+	1	1510	c.618G>A	c.(616-618)CAG>CAA	p.Q206Q	PCDH17_uc010aec.1_Silent_p.Q206Q	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	206	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		GCGAGCAACAGAATCACCATA	0.592		NaN											0	0	0	1	0	14	21				
OXGR1	27199	broad.mit.edu	37	13	97639537	97639537	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr13:97639537G>A	uc001vmx.1	-	4	721	c.477C>T	c.(475-477)ATC>ATT	p.I159I	OXGR1_uc010afr.1_Silent_p.I159I	NM_080818	NP_543008	Q96P68	OXGR1_HUMAN	oxoglutarate (alpha-ketoglutarate) receptor 1	159	Helical; Name=4; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)|skin(1)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.186)			CCAGTGAAATGATCCACACCA	0.478		NaN											0	0	0	1	0	4	46				
MBNL2	10150	broad.mit.edu	37	13	98043621	98043621	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr13:98043621C>T	uc010aft.2	+	8	1856	c.1040C>T	c.(1039-1041)TCT>TTT	p.S347F	MBNL2_uc001vmz.2_3'UTR|MBNL2_uc001vna.2_Missense_Mutation_p.S335F|MBNL2_uc001vnb.2_RNA|MBNL2_uc010tij.1_Missense_Mutation_p.S180F	NM_144778	NP_659002	Q5VZF2	MBNL2_HUMAN	muscleblind-like 2 isoform 1	347					mRNA processing|regulation of RNA splicing|RNA splicing	cytoplasm|nucleus	RNA binding|zinc ion binding				0	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.218)			TGCCAAGAATCTGCATTGAGA	0.343		NaN											0	0	0	1	0	30	56				
DOCK9	23348	broad.mit.edu	37	13	99537285	99537285	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr13:99537285G>A	uc001vnt.2	-	21	2380	c.2325C>T	c.(2323-2325)ATC>ATT	p.I775I	DOCK9_uc001vnw.2_Silent_p.I774I|DOCK9_uc001vnv.1_RNA|DOCK9_uc010tir.1_Silent_p.I775I|DOCK9_uc010tis.1_Silent_p.I774I|DOCK9_uc010tit.1_Silent_p.I775I|DOCK9_uc010afu.1_Silent_p.I621I	NM_015296	NP_056111	Q9BZ29	DOCK9_HUMAN	dedicator of cytokinesis 9 isoform a	775	DHR-1.				blood coagulation	cytosol|endomembrane system|membrane	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			central_nervous_system(1)	1	all_neural(89;0.101)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					CCGAGACCGGGATGTGCTGCT	0.512		NaN											0	0	0	1	0	10	9				
CLYBL	171425	broad.mit.edu	37	13	100518572	100518572	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr13:100518572T>C	uc001vok.2	+	6	727	c.713T>C	c.(712-714)CTC>CCC	p.L238P	CLYBL_uc010tix.1_3'UTR|CLYBL_uc010tiy.1_Missense_Mutation_p.L204P	NM_206808	NP_996531	Q8N0X4	CLYBL_HUMAN	citrate lyase beta like precursor	238					cellular aromatic compound metabolic process	citrate lyase complex|mitochondrion	citrate (pro-3S)-lyase activity|metal ion binding				0	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GCCTTTGGTCTCCAAGCCATA	0.473		NaN											0	0	0	1	0	21	67				
NALCN	259232	broad.mit.edu	37	13	102051408	102051408	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr13:102051408G>A	uc001vox.1	-	2	259	c.70C>T	c.(70-72)CTG>TTG	p.L24L	NALCN_uc001voy.2_5'UTR|NALCN_uc001voz.2_Silent_p.L24L|NALCN_uc001vpa.2_Silent_p.L24L	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	24	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TTATCCGACAGAGACTCATCA	0.443		NaN											0	0	0	1	0	24	44				
SLC10A2	6555	broad.mit.edu	37	13	103718286	103718286	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr13:103718286C>T	uc001vpy.3	-	1	911	c.314G>A	c.(313-315)TGC>TAC	p.C105Y		NM_000452	NP_000443	Q12908	NTCP2_HUMAN	solute carrier family 10 (sodium/bile acid	105	Extracellular (Potential).				bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			ovary(3)|skin(1)	4	all_neural(89;0.0662)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					TCCAGGGCAGCATCCTATAAT	0.512		NaN											0	0	0	1	0	67	6				
IRS2	8660	broad.mit.edu	37	13	110434606	110434606	+	Silent	SNP	T	T	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr13:110434606T>G	uc001vqv.2	-	1	4309	c.3795A>C	c.(3793-3795)CCA>CCC	p.P1265P		NM_003749	NP_003740	Q9Y4H2	IRS2_HUMAN	insulin receptor substrate 2	1265	Poly-Pro.				fibroblast growth factor receptor signaling pathway|glucose metabolic process|insulin receptor signaling pathway|lipid homeostasis|negative regulation of B cell apoptosis|negative regulation of kinase activity|negative regulation of plasma membrane long-chain fatty acid transport|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of B cell proliferation|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|response to glucose stimulus	cytosol|plasma membrane	insulin receptor binding|signal transducer activity			large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|skin(1)|ovary(1)|kidney(1)	8	all_cancers(4;7.57e-15)|all_epithelial(4;5.91e-09)|all_lung(23;7.64e-07)|Lung NSC(43;0.000183)|Colorectal(4;0.00159)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0155)	Breast(118;0.159)	all cancers(43;0.00815)|BRCA - Breast invasive adenocarcinoma(86;0.11)|Epithelial(84;0.127)|GBM - Glioblastoma multiforme(44;0.147)			gcggctggggtggcagcCCGG	0.512		NaN											0	0	0	1	0	8	6				
TEP1	7011	broad.mit.edu	37	14	20856168	20856168	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:20856168G>C	uc001vxe.2	-	18	2620	c.2580C>G	c.(2578-2580)GAC>GAG	p.D860E	TEP1_uc010ahk.2_Missense_Mutation_p.D210E|TEP1_uc010tlf.1_RNA|TEP1_uc010tlg.1_Missense_Mutation_p.D752E	NM_007110	NP_009041	Q99973	TEP1_HUMAN	telomerase-associated protein 1	860					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding			ovary(5)	5	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		TGAATATTTTGTCCATTTGGC	0.507		NaN											0	0	0	1	0	14	18				
RNF31	55072	broad.mit.edu	37	14	24617000	24617001	+	Missense_Mutation	DNP	GG	GG	AA			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:24617000_24617001GG>AA	uc001wmn.1	+	1	342_343	c.93_94GG>AA	c.(91-96)CTGGAG>CTAAAG	p.E32K	PSME2_uc001wmj.2_5'Flank|PSME2_uc001wmk.2_5'Flank|RNF31_uc001wml.1_Intron|RNF31_uc001wmm.1_RNA|RNF31_uc010alg.1_5'Flank	NM_017999	NP_060469	Q96EP0	RNF31_HUMAN	ring finger protein 31	32	Polyubiquitin-binding.				CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00861)		CGTTTTCCCTGGAGCAGCTCCG	0.703		NaN											0	0	0	1	0	2	0				
RNF31	55072	broad.mit.edu	37	14	24619469	24619469	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:24619469G>A	uc001wmn.1	+	7	1258	c.1009G>A	c.(1009-1011)GAG>AAG	p.E337K	RNF31_uc001wml.1_Missense_Mutation_p.E186K|RNF31_uc001wmm.1_Intron|RNF31_uc010alg.1_Missense_Mutation_p.E152K|RNF31_uc001wmo.1_5'Flank|RNF31_uc001wmp.2_5'Flank	NM_017999	NP_060469	Q96EP0	RNF31_HUMAN	ring finger protein 31	337	Polyubiquitin-binding.				CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00861)		GTTGGGAACTGAGGGTCCCCA	0.602		NaN											0	0	0	1	0	36	2				
RNF31	55072	broad.mit.edu	37	14	24619594	24619594	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:24619594G>A	uc001wmn.1	+	7	1383	c.1134G>A	c.(1132-1134)CTG>CTA	p.L378L	RNF31_uc001wml.1_Silent_p.L227L|RNF31_uc001wmm.1_Intron|RNF31_uc010alg.1_Silent_p.L193L|RNF31_uc001wmo.1_5'Flank|RNF31_uc001wmp.2_5'Flank	NM_017999	NP_060469	Q96EP0	RNF31_HUMAN	ring finger protein 31	378	RanBP2-type 2.|Polyubiquitin-binding.				CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00861)		GACCTCGGCTGGCCCAGCCTC	0.567		NaN											0	0	0	1	0	53	4				
RNF31	55072	broad.mit.edu	37	14	24620038	24620038	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:24620038G>A	uc001wmn.1	+	8	1678	c.1429G>A	c.(1429-1431)GAG>AAG	p.E477K	RNF31_uc001wml.1_Missense_Mutation_p.E326K|RNF31_uc001wmm.1_Intron|RNF31_uc010alg.1_Missense_Mutation_p.E292K|RNF31_uc001wmo.1_5'Flank|RNF31_uc001wmp.2_5'Flank	NM_017999	NP_060469	Q96EP0	RNF31_HUMAN	ring finger protein 31	477	Polyubiquitin-binding.				CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00861)		TGGAGATCCTGAGAAGCAGCG	0.632		NaN											0	0	0	1	0	28	1				
FOXG1	2290	broad.mit.edu	37	14	29237037	29237037	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:29237037C>G	uc001wqe.2	+	1	751	c.552C>G	c.(550-552)TTC>TTG	p.F184L		NM_005249	NP_005240	P55316	FOXG1_HUMAN	forkhead box G1	184	Fork-head.				axon midline choice point recognition|central nervous system neuron development|dorsal/ventral pattern formation|embryo development ending in birth or egg hatching|hindbrain development|inner ear morphogenesis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|nonmotile primary cilium assembly|nose development|positive regulation of cell cycle|positive regulation of neuroblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of mitotic cell cycle|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			ovary(2)|lung(2)	4			LUAD - Lung adenocarcinoma(48;0.011)|Lung(238;0.0575)	GBM - Glioblastoma multiforme(265;0.00413)		AGCCGCCGTTCAGCTACAACG	0.353		NaN											0	0	0	1	0	20	1				
HECTD1	25831	broad.mit.edu	37	14	31598292	31598292	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:31598292G>C	uc001wrc.1	-	25	4774	c.4285C>G	c.(4285-4287)CTT>GTT	p.L1429V	HECTD1_uc001wrb.1_5'UTR|HECTD1_uc001wrd.1_Missense_Mutation_p.L897V	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	1429	Ser-rich.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		GCAGATGAAAGAACAACAATT	0.453		NaN											0	0	0	1	0	36	55				
FANCM	57697	broad.mit.edu	37	14	45668041	45668041	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:45668041G>A	uc001wwd.3	+	22	6010	c.5911G>A	c.(5911-5913)GAG>AAG	p.E1971K	FANCM_uc010anf.2_Missense_Mutation_p.E1945K|FANCM_uc001wwe.3_Missense_Mutation_p.E1507K|FANCM_uc010ang.2_Missense_Mutation_p.E1220K	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	1971	Interaction with FAAP24 and EME1.				DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						TAATAAAAGTGAGGCACTCCA	0.348		NaN						Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	1	0	31	5				
CNIH	10175	broad.mit.edu	37	14	54898890	54898890	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:54898890G>C	uc001xat.1	-	3	302	c.199C>G	c.(199-201)CTT>GTT	p.L67V	CNIH_uc001xav.1_Missense_Mutation_p.L67V	NM_005776	NP_005767	O95406	CNIH_HUMAN	cornichon-like	67	Helical; (Potential).				immune response|intracellular signal transduction|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane|integral to membrane					0				GBM - Glioblastoma multiforme(112;0.00341)		GCTGCACAAAGAAACATGACA	0.388		NaN											0	0	0	1	0	3	2				
C14orf149	112849	broad.mit.edu	37	14	59950883	59950883	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:59950883C>T	uc001xee.1	-	1	191	c.152G>A	c.(151-153)CGG>CAG	p.R51Q	C14orf149_uc010trx.1_Missense_Mutation_p.R51Q|JKAMP_uc001xef.3_5'Flank|JKAMP_uc001xeh.3_5'Flank|JKAMP_uc001xeg.3_5'Flank|JKAMP_uc010try.1_5'Flank|JKAMP_uc001xei.3_5'Flank	NM_144581	NP_653182	Q96EM0	PRCM_HUMAN	proline racemase-like	51							proline racemase activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.14)	L-Proline(DB00172)	CATGTAGCGCCGCTTGGCCAG	0.701		NaN									OREG0022712	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	5	6				
PRKCH	5583	broad.mit.edu	37	14	61995799	61995799	+	Silent	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:61995799G>C	uc001xfn.2	+	11	1745	c.1440G>C	c.(1438-1440)CTG>CTC	p.L480L	PRKCH_uc010tsa.1_Silent_p.L319L|PRKCH_uc010tsb.1_Silent_p.L48L	NM_006255	NP_006246	P24723	KPCL_HUMAN	protein kinase C, eta	480	Protein kinase.				intracellular signal transduction|platelet activation	cytosol|plasma membrane	ATP binding|enzyme binding|metal ion binding|protein kinase C activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)|large_intestine(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(108;0.045)|BRCA - Breast invasive adenocarcinoma(234;0.0906)|KIRC - Kidney renal clear cell carcinoma(182;0.182)		TCAGAGATCTGAAACTGGACA	0.453		NaN											0	0	0	1	0	36	2				
SYNE2	23224	broad.mit.edu	37	14	64467418	64467418	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:64467418C>T	uc001xgm.2	+	28	3849	c.3619C>T	c.(3619-3621)CAG>TAG	p.Q1207*	SYNE2_uc001xgl.2_Nonsense_Mutation_p.Q1207*	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	1207	Cytoplasmic (Potential).|Potential.				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AAGAGAGCTTCAGATGACTCT	0.294		NaN											0	0	0	1	0	17	29				
C14orf45	80127	broad.mit.edu	37	14	74514682	74514682	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:74514682C>T	uc010tup.1	+	7	820	c.697C>T	c.(697-699)CAG>TAG	p.Q233*	C14orf45_uc001xpm.1_RNA	NM_025057	NP_079333	Q8ND07	CN045_HUMAN	hypothetical protein LOC80127	233											0				BRCA - Breast invasive adenocarcinoma(234;0.00351)		TGATTATCTTCAGAAAGCTCT	0.363		NaN											0	0	0	1	0	12	17				
KIAA0317	9870	broad.mit.edu	37	14	75130693	75130693	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:75130693G>A	uc001xqb.2	-	19	2783	c.2278C>T	c.(2278-2280)CAG>TAG	p.Q760*	KIAA0317_uc010tut.1_Nonsense_Mutation_p.Q599*	NM_001039479	NP_001034568	O15033	K0317_HUMAN	hypothetical protein LOC9870	760	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane|intracellular	ubiquitin-protein ligase activity			ovary(2)|kidney(1)|central_nervous_system(1)|pancreas(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00404)		GGTGGTAGCTGAGAGGAGCCT	0.562		NaN											0	0	0	1	0	18	44				
ISM2	145501	broad.mit.edu	37	14	77942212	77942212	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:77942212G>C	uc001xtz.2	-	7	1516	c.1442C>G	c.(1441-1443)TCT>TGT	p.S481C	ISM2_uc001xua.2_3'UTR|ISM2_uc001xty.2_Missense_Mutation_p.S393C|ISM2_uc010tvl.1_Missense_Mutation_p.S400C	NM_199296	NP_954993	Q6H9L7	ISM2_HUMAN	isthmin 2 homolog isoform 1	481	AMOP.					extracellular region				skin(1)	1						GCTCTCCCCAGACAGCATGGA	0.687		NaN											0	0	0	1	0	5	40				
DIO2	1734	broad.mit.edu	37	14	80677657	80677657	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:80677657G>A	uc010tvq.1	-	2	561	c.159C>T	c.(157-159)CGC>CGT	p.R53R	uc001xuw.1_5'Flank|DIO2_uc010tvp.1_Silent_p.R53R|DIO2_uc001xut.2_RNA|DIO2_uc010asx.2_Silent_p.R53R|DIO2_uc010tvr.1_Silent_p.R53R|DIO2_uc010asy.2_Silent_p.R53R	NM_000793	NP_000784	Q92813	IOD2_HUMAN	deiodinase, iodothyronine, type II isoform a	53					hormone biosynthetic process|selenocysteine incorporation|thyroid hormone generation	integral to membrane|plasma membrane	thyroxine 5'-deiodinase activity|ubiquitin protein ligase binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.0281)		AGGTCAGCATGCGCCGCCACT	0.592		NaN											0	0	0	1	0	16	16				
FOXN3	1112	broad.mit.edu	37	14	89817116	89817116	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:89817116C>G	uc001xxo.3	-	3	717	c.580G>C	c.(580-582)GAG>CAG	p.E194Q	FOXN3_uc001xxn.3_Missense_Mutation_p.E194Q|FOXN3_uc010atk.2_Missense_Mutation_p.E194Q	NM_001085471	NP_001078940	O00409	FOXN3_HUMAN	checkpoint suppressor 1 isoform 1	194	Fork-head.				DNA damage checkpoint|embryo development|G2 phase of mitotic cell cycle|negative regulation of transcription, DNA-dependent|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein C-terminus binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			skin(2)|ovary(1)	3						TGTCTATACTCTGGGTCTATG	0.388		NaN											0	0	0	1	0	26	54				
RPS6KA5	9252	broad.mit.edu	37	14	91367073	91367073	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:91367073G>C	uc001xys.2	-	10	1342	c.1127C>G	c.(1126-1128)TCC>TGC	p.S376C	RPS6KA5_uc010twi.1_Missense_Mutation_p.S297C|RPS6KA5_uc001xyt.2_Missense_Mutation_p.S376C|RPS6KA5_uc010att.1_RNA	NM_004755	NP_004746	O75582	KS6A5_HUMAN	ribosomal protein S6 kinase, polypeptide 5	376	AGC-kinase C-terminal.			S->A: Loss of kinase activity, and decreases the phosphorylation of S-360 and T-581.	axon guidance|epidermal growth factor receptor signaling pathway|histone phosphorylation|innate immune response|interleukin-1-mediated signaling pathway|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of histone acetylation|positive regulation of histone phosphorylation|positive regulation of transcription from RNA polymerase II promoter|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(1)	1		all_cancers(154;0.0148)|Melanoma(154;0.099)|all_epithelial(191;0.146)		Epithelial(152;0.182)|BRCA - Breast invasive adenocarcinoma(234;0.201)		AGCAACAAAGGAATAGCCCTA	0.378		NaN											0	0	0	1	0	11	17				
TC2N	123036	broad.mit.edu	37	14	92253884	92253884	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:92253884G>T	uc001xzu.3	-	10	1326	c.1135C>A	c.(1135-1137)CCA>ACA	p.P379T	TC2N_uc001xzt.3_Missense_Mutation_p.P379T|TC2N_uc010auc.2_Missense_Mutation_p.P315T|TC2N_uc001xzv.3_Missense_Mutation_p.P379T	NM_001128595	NP_001122067	Q8N9U0	TAC2N_HUMAN	tandem C2 domains, nuclear	379	C2.					nucleus				upper_aerodigestive_tract(1)	1				COAD - Colon adenocarcinoma(157;0.218)		GATGAGCTTGGAAGGTACCGT	0.348		NaN											1	0	3.09899e-07	1	3.2626e-07	9	31				
TC2N	123036	broad.mit.edu	37	14	92253914	92253914	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:92253914G>C	uc001xzu.3	-	10	1296	c.1105C>G	c.(1105-1107)CAG>GAG	p.Q369E	TC2N_uc001xzt.3_Missense_Mutation_p.Q369E|TC2N_uc010auc.2_Missense_Mutation_p.Q305E|TC2N_uc001xzv.3_Missense_Mutation_p.Q369E	NM_001128595	NP_001122067	Q8N9U0	TAC2N_HUMAN	tandem C2 domains, nuclear	369	C2.					nucleus				upper_aerodigestive_tract(1)	1				COAD - Colon adenocarcinoma(157;0.218)		ATTTGTAACTGAATTCTGCTA	0.363		NaN											0	0	0	1	0	12	37				
SERPINA3	12	broad.mit.edu	37	14	95080891	95080891	+	Missense_Mutation	SNP	A	A	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:95080891A>C	uc001ydp.2	+	2	192	c.113A>C	c.(112-114)AAC>ACC	p.N38T	SERPINA3_uc001ydo.3_Missense_Mutation_p.N63T|SERPINA3_uc010avf.1_RNA|SERPINA3_uc001ydr.2_RNA|SERPINA3_uc001ydq.2_Missense_Mutation_p.N38T|SERPINA3_uc001yds.2_Missense_Mutation_p.N38T|SERPINA3_uc010avg.2_Missense_Mutation_p.N38T	NM_001085	NP_001076	P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A, member 3	38					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|skin(1)	6		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		ACCCAGGAGAACCAAGACCGA	0.587		NaN											0	0	0	1	0	28	71				
DICER1	23405	broad.mit.edu	37	14	95570291	95570291	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:95570291G>C	uc001ydw.2	-	22	3624	c.3442C>G	c.(3442-3444)CAA>GAA	p.Q1148E	DICER1_uc010avh.1_Missense_Mutation_p.Q46E|DICER1_uc001ydv.2_Missense_Mutation_p.Q1138E|DICER1_uc001ydx.2_Missense_Mutation_p.Q1148E|DICER1_uc001ydy.1_5'UTR	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	1148					negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		ACAGACATTTGGTCATGATTT	0.418		NaN	Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				0	0	0	1	0	36	18				
CCNK	8812	broad.mit.edu	37	14	99959910	99959910	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:99959910C>T	uc001ygi.3	+	3	387	c.257C>T	c.(256-258)TCC>TTC	p.S86F	CCNK_uc001ygg.3_Missense_Mutation_p.S86F	NM_001099402	NP_001092872	O75909	CCNK_HUMAN	cyclin K isoform 1	86					cell division|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein kinase binding				0		all_cancers(154;0.224)|all_epithelial(191;0.0643)|Melanoma(154;0.0866)				ATGTTTCATTCCTTCAAGCAA	0.328		NaN											0	0	0	1	0	13	14				
ASPG	374569	broad.mit.edu	37	14	104552129	104552129	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:104552129G>T	uc001yoq.1	+	1	82	c.22G>T	c.(22-24)GAG>TAG	p.E8*	ASPG_uc001yoo.1_5'UTR|ASPG_uc001yop.1_Nonsense_Mutation_p.E8*|ASPG_uc001yor.1_Nonsense_Mutation_p.E8*	NM_001080464	NP_001073933	Q86U10	LPP60_HUMAN	60 kDa lysophospholipase	8					lipid catabolic process		1-alkyl-2-acetylglycerophosphocholine esterase activity|asparaginase activity|lysophospholipase activity				0						GGTGGGGCCCGAGCGGAGGCT	0.746		NaN											1	0	1.12685e-05	1	1.16464e-05	9	5				
AHNAK2	113146	broad.mit.edu	37	14	105410361	105410361	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:105410361C>G	uc010axc.1	-	7	11547	c.11427G>C	c.(11425-11427)AAG>AAC	p.K3809N	AHNAK2_uc001ypx.2_Missense_Mutation_p.K3709N	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	3809						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			ATGACGGCATCTTGAACTTGG	0.572		NaN											0	0	0	1	0	94	204				
CRIP1	1396	broad.mit.edu	37	14	105954549	105954549	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:105954549G>A	uc001yri.3	+	3	201	c.87G>A	c.(85-87)CTG>CTA	p.L29L	C14orf80_uc001yrj.2_5'Flank|C14orf80_uc001yrk.2_5'Flank	NM_001311	NP_001302	P50238	CRIP1_HUMAN	cysteine-rich protein 1 (intestinal)	29	LIM zinc-binding.				cell proliferation	cytoplasm	zinc ion binding				0		Melanoma(154;0.226)	OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0188)	Epithelial(152;0.235)		GGCCCTGCCTGAAGTGCGAGA	0.682		NaN											0	0	0	1	0	18	33				
CYFIP1	23191	broad.mit.edu	37	15	22993125	22993125	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:22993125C>T	uc001yus.2	+	26	3116	c.3012C>T	c.(3010-3012)ATC>ATT	p.I1004I	CYFIP1_uc001yut.2_Silent_p.I1004I|CYFIP1_uc010aya.1_Silent_p.I1032I|CYFIP1_uc001yuu.2_Silent_p.I573I|CYFIP1_uc001yuv.2_Silent_p.I198I	NM_014608	NP_055423	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1 isoform	1004					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			ovary(4)|pancreas(3)|liver(1)|skin(1)	9		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		GGAACGCCATCCTCTTCTGCC	0.498		NaN											0	0	0	1	0	41	23				
HERC2	8924	broad.mit.edu	37	15	28377404	28377404	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:28377404C>G	uc001zbj.2	-	81	12518	c.12412G>C	c.(12412-12414)GAG>CAG	p.E4138Q		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	4138	RCC1 16.				DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		TGCAGCGCCTCCACCTTCAGA	0.567		NaN											0	0	0	1	0	3	14				
TRPM1	4308	broad.mit.edu	37	15	31352839	31352839	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:31352839C>G	uc001zfm.2	-	10	1233	c.1105G>C	c.(1105-1107)GTA>CTA	p.V369L	TRPM1_uc010azy.2_Missense_Mutation_p.V276L|TRPM1_uc001zfl.2_RNA	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	369	Extracellular (Potential).			V -> L (in Ref. 2; BAC80200).	cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		GGAGCAGATACGTTTGTTCCT	0.562		NaN											0	0	0	1	0	6	11				
RYR3	6263	broad.mit.edu	37	15	33961642	33961642	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:33961642C>T	uc001zhi.2	+	37	5777	c.5707C>T	c.(5707-5709)CTT>TTT	p.L1903F	RYR3_uc010bar.2_Missense_Mutation_p.L1903F	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	1903	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CCATGAGGACCTTCTCCTTCA	0.458		NaN											0	0	0	1	0	20	13				
RYR3	6263	broad.mit.edu	37	15	33988667	33988667	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:33988667G>A	uc001zhi.2	+	39	6179	c.6109G>A	c.(6109-6111)GAG>AAG	p.E2037K	RYR3_uc010bar.2_Missense_Mutation_p.E2037K	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2037	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CAAGGAAGAGGAGTTGCTCAT	0.522		NaN											0	0	0	1	0	20	15				
RYR3	6263	broad.mit.edu	37	15	34113731	34113731	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:34113731G>A	uc001zhi.2	+	80	10993	c.10923G>A	c.(10921-10923)ATG>ATA	p.M3641I	RYR3_uc010bar.2_Missense_Mutation_p.M3636I	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	3641					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CAGGTGAGATGAGCCCCATGG	0.527		NaN											0	0	0	1	0	11	29				
C15orf55	256646	broad.mit.edu	37	15	34647761	34647761	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:34647761C>T	uc001zif.2	+	7	1623	c.1468C>T	c.(1468-1470)CAG>TAG	p.Q490*	C15orf55_uc010ucc.1_Nonsense_Mutation_p.Q518*|C15orf55_uc010ucd.1_Nonsense_Mutation_p.Q508*	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	490						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		CAGTGGCGCTCAGTTGGACTC	0.572		NaN	T	BRD3|BRD4	lethal midline carcinoma								0	0	0	1	0	17	48				
SPRED1	161742	broad.mit.edu	37	15	38614540	38614540	+	Silent	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:38614540G>T	uc001zka.3	+	3	641	c.306G>T	c.(304-306)ACG>ACT	p.T102T		NM_152594	NP_689807	Q7Z699	SPRE1_HUMAN	sprouty-related protein 1 with EVH-1 domain	102	WH1.				inactivation of MAPK activity|multicellular organismal development	caveola|nucleus	stem cell factor receptor binding			ovary(2)|lung(2)|skin(1)	5		all_cancers(109;4.88e-13)|all_epithelial(112;1.83e-11)|Lung NSC(122;2.21e-09)|all_lung(180;4.64e-08)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(113;2.41e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		TTGGTCTTACGTTTCAAAGTC	0.363		NaN							Legius_syndrome				1	0	1.67942e-08	1	1.77359e-08	17	76				
C15orf52	388115	broad.mit.edu	37	15	40632197	40632197	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:40632197G>A	uc001zlh.3	-	2	180	c.164C>T	c.(163-165)TCC>TTC	p.S55F	C15orf52_uc001zli.1_5'UTR|C15orf52_uc010ucn.1_5'Flank	NM_207380	NP_997263	Q6ZUT6	CO052_HUMAN	hypothetical protein LOC388115	55										large_intestine(1)	1		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.06e-06)|Colorectal(105;0.0107)|BRCA - Breast invasive adenocarcinoma(123;0.0505)|READ - Rectum adenocarcinoma(2;0.0649)|Lung(196;0.0781)|LUAD - Lung adenocarcinoma(183;0.0841)		GCTCATGGGGGACTCGGCTCT	0.612		NaN											0	0	0	1	0	18	9				
SPTBN5	51332	broad.mit.edu	37	15	42178522	42178522	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:42178522A>G	uc001zos.2	-	7	1159	c.826T>C	c.(826-828)TAC>CAC	p.Y276H		NM_016642	NP_057726	Q9NRC6	SPTN5_HUMAN	spectrin, beta, non-erythrocytic 5	311	Spectrin 1.				actin cytoskeleton organization|actin filament capping|axon guidance	cytosol|membrane|spectrin				ovary(1)|central_nervous_system(1)	2		all_cancers(109;1.84e-17)|all_epithelial(112;1.12e-15)|Lung NSC(122;7.6e-10)|all_lung(180;4.15e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.173)		all cancers(2;4.33e-34)|Epithelial(2;1.72e-25)|OV - Ovarian serous cystadenocarcinoma(18;8.32e-20)|GBM - Glioblastoma multiforme(94;4.69e-07)|Colorectal(2;0.00104)|COAD - Colon adenocarcinoma(120;0.0405)|READ - Rectum adenocarcinoma(92;0.0908)		AGCTGCTCGTACTGGGTCTGC	0.622		NaN											0	0	0	1	0	3	18				
PLA2G4D	283748	broad.mit.edu	37	15	42364006	42364006	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:42364006C>A	uc001zox.2	-	15	1634	c.1539G>T	c.(1537-1539)AGG>AGT	p.R513S		NM_178034	NP_828848	Q86XP0	PA24D_HUMAN	phospholipase A2, group IVD	513	PLA2c.				phospholipid catabolic process	cytoplasmic vesicle membrane|cytosol	metal ion binding|phospholipase A2 activity			large_intestine(1)|skin(1)	2		all_cancers(109;6.37e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.019)|Ovarian(310;0.143)|Colorectal(260;0.245)		OV - Ovarian serous cystadenocarcinoma(18;4.9e-17)|GBM - Glioblastoma multiforme(94;1.02e-06)		CCGGGATCCTCCTCATCAGCC	0.617		NaN											1	0	9.05144e-12	1	9.79289e-12	14	34				
CDAN1	146059	broad.mit.edu	37	15	43018340	43018340	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:43018340C>A	uc001zql.2	-	25	3340	c.3223G>T	c.(3223-3225)GAG>TAG	p.E1075*	CDAN1_uc001zqj.2_RNA|CDAN1_uc001zqk.2_Nonsense_Mutation_p.E401*	NM_138477	NP_612486	Q8IWY9	CDAN1_HUMAN	codanin 1	1075						integral to membrane	protein binding			ovary(2)	2		all_cancers(109;5.4e-16)|all_epithelial(112;2.97e-14)|Lung NSC(122;1.75e-08)|all_lung(180;5.99e-08)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;2.49e-07)		AGATGCTGCTCAGCAGGTGGG	0.562		NaN											1	0	1.12685e-05	1	1.16464e-05	8	31				
TUBGCP4	27229	broad.mit.edu	37	15	43675567	43675567	+	Silent	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:43675567C>G	uc001zro.2	+	7	828	c.588C>G	c.(586-588)CTC>CTG	p.L196L	TUBGCP4_uc001zrn.2_Silent_p.L196L|TUBGCP4_uc010bdh.2_RNA	NM_014444	NP_055259	Q9UGJ1	GCP4_HUMAN	tubulin, gamma complex associated protein 4	196					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	structural constituent of cytoskeleton			ovary(3)	3		all_cancers(109;1.27e-10)|all_epithelial(112;4.82e-09)|Lung NSC(122;1.72e-06)|all_lung(180;1.59e-05)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;3.53e-07)		ATGGACTCCTCTTGGACCAGC	0.517		NaN											0	0	0	1	0	21	34				
FBN1	2200	broad.mit.edu	37	15	48703211	48703211	+	Missense_Mutation	SNP	C	C	G	rs139679866		TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:48703211C>G	uc001zwx.1	-	66	8920	c.8592G>C	c.(8590-8592)ATG>ATC	p.M2864I	FBN1_uc010beo.1_RNA	NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	2864					heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		CCTGGATTTTCATCTTCAGAT	0.328		NaN											0	0	0	1	0	11	34				
COPS2	9318	broad.mit.edu	37	15	49437194	49437194	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:49437194C>T	uc001zxf.2	-	2	215	c.136G>A	c.(136-138)GAC>AAC	p.D46N	COPS2_uc001zxh.2_Missense_Mutation_p.D46N|COPS2_uc010ufa.1_Intron	NM_004236	NP_004227	P61201	CSN2_HUMAN	COP9 constitutive photomorphogenic homolog	46					cullin deneddylation|transcription from RNA polymerase II promoter	cytoplasm|signalosome	protein binding|signal transducer activity			lung(1)	1		all_lung(180;0.0428)		all cancers(107;1.34e-07)|GBM - Glioblastoma multiforme(94;3.02e-05)		GCTTTTGGGTCATCTTCTTTT	0.323		NaN											0	0	0	1	0	27	33				
GLDN	342035	broad.mit.edu	37	15	51634220	51634220	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:51634220G>A	uc002aba.2	+	1	508	c.339G>A	c.(337-339)ATG>ATA	p.M113I	GLDN_uc010bez.1_Missense_Mutation_p.M113I	NM_181789	NP_861454	Q6ZMI3	GLDN_HUMAN	gliomedin	113	Extracellular (Potential).				cell differentiation|nervous system development	collagen|integral to membrane|plasma membrane				ovary(2)	2				all cancers(107;0.00194)|GBM - Glioblastoma multiforme(94;0.00942)		ACATGCTGATGATGATGACCT	0.711		NaN											0	0	0	1	0	14	37				
LEO1	123169	broad.mit.edu	37	15	52242065	52242065	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:52242065C>T	uc002abo.2	-	10	1754	c.1738G>A	c.(1738-1740)GAA>AAA	p.E580K	LEO1_uc010bfd.2_Missense_Mutation_p.E520K	NM_138792	NP_620147	Q8WVC0	LEO1_HUMAN	Leo1, Paf1/RNA polymerase II complex component,	580					histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding				0				all cancers(107;0.00264)		TCCTCGCCTTCCTCCTCCTCA	0.512		NaN											0	0	0	1	0	27	58				
ZNF280D	54816	broad.mit.edu	37	15	56981644	56981644	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:56981644G>C	uc002adu.2	-	8	741	c.524C>G	c.(523-525)TCA>TGA	p.S175*	ZNF280D_uc002adv.2_Nonsense_Mutation_p.S162*|ZNF280D_uc010bfq.2_Nonsense_Mutation_p.S175*|ZNF280D_uc002adw.1_Nonsense_Mutation_p.S203*|ZNF280D_uc010bfr.1_RNA	NM_017661	NP_060131	Q6N043	Z280D_HUMAN	suppressor of hairy wing homolog 4 isoform 1	175					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.0399)|GBM - Glioblastoma multiforme(80;0.0787)		AGGACGTTTTGATAAAAATGA	0.279		NaN											0	0	0	1	0	10	15				
CGNL1	84952	broad.mit.edu	37	15	57730472	57730472	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:57730472C>G	uc002aeg.2	+	2	351	c.275C>G	c.(274-276)TCT>TGT	p.S92C	CGNL1_uc010bfw.2_Missense_Mutation_p.S92C	NM_032866	NP_116255	Q0VF96	CGNL1_HUMAN	cingulin-like 1	92	Head.					myosin complex|tight junction	motor activity			skin(6)|ovary(4)|central_nervous_system(1)	11				all cancers(107;0.121)|GBM - Glioblastoma multiforme(80;0.186)		AGCAATGGTTCTGTGCCAAAG	0.502		NaN											0	0	0	1	0	11	44				
RNF111	54778	broad.mit.edu	37	15	59323779	59323779	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:59323779C>G	uc002afv.2	+	2	1037	c.758C>G	c.(757-759)TCT>TGT	p.S253C	RNF111_uc002afs.2_Missense_Mutation_p.S253C|RNF111_uc002aft.2_Missense_Mutation_p.S253C|RNF111_uc002afu.2_Missense_Mutation_p.S253C|RNF111_uc002afw.2_Missense_Mutation_p.S253C	NM_017610	NP_060080	Q6ZNA4	RN111_HUMAN	ring finger protein 111	253	Ser-rich.|Interaction with AXIN1.				multicellular organismal development|positive regulation of transcription, DNA-dependent	cytoplasm|nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2				all cancers(107;0.194)		CTACCTAGTTCTAGTAGTTCC	0.408		NaN											0	0	0	1	0	6	118				
PLEKHO2	80301	broad.mit.edu	37	15	65157298	65157298	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:65157298G>A	uc002anv.2	+	6	818	c.684G>A	c.(682-684)GAG>GAA	p.E228E	PLEKHO2_uc010bgz.2_Intron|PLEKHO2_uc002anw.2_Silent_p.E178E	NM_025201	NP_079477	Q8TD55	PKHO2_HUMAN	pleckstrin homology domain containing, family O	228	Pro-rich.									ovary(1)|lung(1)	2						CTGTGGGGGAGAGAGCCCCAA	0.637		NaN											0	0	0	1	0	8	83				
MTFMT	123263	broad.mit.edu	37	15	65295436	65295436	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:65295436C>G	uc002aof.3	-	9	1160	c.1134G>C	c.(1132-1134)CAG>CAC	p.Q378H		NM_139242	NP_640335	Q96DP5	FMT_HUMAN	mitochondrial methionyl-tRNA formyltransferase	378						mitochondrion	methionyl-tRNA formyltransferase activity|methyltransferase activity			ovary(2)	2					Tetrahydrofolic acid(DB00116)	CAGTTTTTTTCTGCTTCTTCT	0.348		NaN											0	0	0	1	0	14	20				
SLC24A1	9187	broad.mit.edu	37	15	65917858	65917858	+	Silent	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:65917858C>A	uc010ujf.1	+	2	1727	c.1440C>A	c.(1438-1440)GCC>GCA	p.A480A	SLC24A1_uc010ujd.1_Silent_p.A480A|SLC24A1_uc010uje.1_Silent_p.A480A|SLC24A1_uc010ujg.1_Silent_p.A480A|SLC24A1_uc010ujh.1_Silent_p.A480A	NM_004727	NP_004718	O60721	NCKX1_HUMAN	solute carrier family 24	480	Cytoplasmic (Potential).				response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity				0						TCGTTCCAGCCCTGGGTGTCA	0.582		NaN											1	0	1.58986e-06	1	1.65835e-06	10	94				
UACA	55075	broad.mit.edu	37	15	70960935	70960935	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:70960935C>G	uc002asr.2	-	16	2192	c.2088G>C	c.(2086-2088)CAG>CAC	p.Q696H	UACA_uc010uke.1_Missense_Mutation_p.Q587H|UACA_uc002asq.2_Missense_Mutation_p.Q683H|UACA_uc010bin.1_Missense_Mutation_p.Q671H	NM_018003	NP_060473	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and	696	Potential.					cytoskeleton|extracellular region				ovary(2)|pancreas(1)|skin(1)	4						CTCCTGATTTCTGTTCTAATC	0.363		NaN											0	0	0	1	0	27	59				
C15orf60	283677	broad.mit.edu	37	15	73848666	73848666	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:73848666G>C	uc002avq.2	+	5	598	c.570G>C	c.(568-570)CAG>CAC	p.Q190H	C15orf60_uc010bjb.2_Missense_Mutation_p.Q162H	NM_001042367	NP_001035826	Q7Z4M0	CO060_HUMAN	hypothetical protein LOC283677	190										pancreas(1)	1						CAGAACAACAGCAAGTGTGTG	0.443		NaN											0	0	0	1	0	12	34				
CCDC33	80125	broad.mit.edu	37	15	74573088	74573088	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:74573088G>C	uc002axo.2	+	9	1363	c.969G>C	c.(967-969)AAG>AAC	p.K323N	CCDC33_uc002axp.2_Missense_Mutation_p.K145N	NM_025055	NP_079331	Q8N5R6	CCD33_HUMAN	coiled-coil domain containing 33 isoform 1	526							protein binding			ovary(3)|skin(2)	5						TGTACCAGAAGATGCTGACAG	0.577		NaN											0	0	0	1	0	17	55				
LMAN1L	79748	broad.mit.edu	37	15	75108987	75108987	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:75108987C>T	uc002ayt.1	+	4	455	c.453C>T	c.(451-453)ATC>ATT	p.I151I	LMAN1L_uc010bkd.2_Silent_p.I79I|LMAN1L_uc010ulo.1_Silent_p.I43I|LMAN1L_uc010bke.1_Silent_p.I151I	NM_021819	NP_068591	Q9HAT1	LMA1L_HUMAN	lectin, mannose-binding, 1 like precursor	151	Lumenal (Potential).|L-type lectin-like.					ER-Golgi intermediate compartment membrane|integral to membrane	sugar binding				0						GTCCTGCCATCCGTGTGCTGG	0.488		NaN											0	0	0	1	0	5	47				
PTPN9	5780	broad.mit.edu	37	15	75798197	75798197	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:75798197C>T	uc002bal.2	-	7	1295	c.787G>A	c.(787-789)GAG>AAG	p.E263K		NM_002833	NP_002824	P43378	PTN9_HUMAN	protein tyrosine phosphatase, non-receptor type	263						cytoplasmic part	non-membrane spanning protein tyrosine phosphatase activity|protein binding			lung(1)|skin(1)	2						AGGATGATCTCATCGAAGGGA	0.512		NaN											0	0	0	1	0	29	15				
SGK269	79834	broad.mit.edu	37	15	77407505	77407505	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:77407505C>G	uc002bcm.2	-	6	4542	c.4234G>C	c.(4234-4236)GAA>CAA	p.E1412Q		NM_024776	NP_079052	Q9H792	PEAK1_HUMAN	NKF3 kinase family member	1412	Protein kinase.				cell migration|protein autophosphorylation|substrate adhesion-dependent cell spreading	actin cytoskeleton|cytoplasm|focal adhesion	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding				0				STAD - Stomach adenocarcinoma(199;0.124)		TCATCCTTTTCAGGGTCATCT	0.498		NaN											0	0	0	1	0	17	58				
ACAN	176	broad.mit.edu	37	15	89398590	89398590	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:89398590G>A	uc010upo.1	+	12	3148	c.2774G>A	c.(2773-2775)AGA>AAA	p.R925K	ACAN_uc010upp.1_Missense_Mutation_p.R925K|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	925					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			GATGAAGAGAGAATTGAGTGG	0.577		NaN											0	0	0	1	0	15	32				
C15orf58	390637	broad.mit.edu	37	15	90784743	90784743	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:90784743C>T	uc002bpc.2	+	4	782	c.603C>T	c.(601-603)TTC>TTT	p.F201F		NM_001013657	NP_001013679	Q6ZNW5	VTC2_HUMAN	hypothetical protein LOC390637	201					glucose metabolic process	cytoplasm	GDP-D-glucose phosphorylase activity				0						ACCCGGGCTTCCGTGTCGGCT	0.667		NaN											0	0	0	1	0	12	25				
PCSK6	5046	broad.mit.edu	37	15	101872078	101872078	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:101872078C>A	uc002bwy.2	-	15	2331	c.2017G>T	c.(2017-2019)GAA>TAA	p.E673*	PCSK6_uc010bpd.2_Nonsense_Mutation_p.E469*|PCSK6_uc010bpe.2_Nonsense_Mutation_p.E673*|PCSK6_uc002bxa.2_Nonsense_Mutation_p.E673*|PCSK6_uc002bxb.2_Nonsense_Mutation_p.E673*	NM_002570	NP_002561	P29122	PCSK6_HUMAN	paired basic amino acid cleaving system 4	673					glycoprotein metabolic process|nerve growth factor processing|nerve growth factor production|nerve growth factor receptor signaling pathway|regulation of BMP signaling pathway|secretion by cell	cell surface|endomembrane system|endoplasmic reticulum|extracellular matrix|extracellular space|Golgi lumen|membrane|soluble fraction	eukaryotic cell surface binding|heparin binding|nerve growth factor binding|serine-type endopeptidase activity			pancreas(2)	2	Lung NSC(78;0.00102)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000803)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			TCCTCATCTTCAGGAACTTCC	0.557		NaN											1	0	0.014758	1	0.0148163	4	46				
RHBDF1	64285	broad.mit.edu	37	16	111597	111597	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:111597C>T	uc002cfl.3	-	12	1454	c.1306G>A	c.(1306-1308)GAG>AAG	p.E436K	RHBDF1_uc010uty.1_Missense_Mutation_p.E459K|RHBDF1_uc010utz.1_Missense_Mutation_p.E436K|RHBDF1_uc010bqo.1_RNA	NM_022450	NP_071895	Q96CC6	RHDF1_HUMAN	rhomboid family 1	436	Lumenal (Potential).				cell migration|cell proliferation|negative regulation of protein secretion|protein transport|proteolysis|regulation of epidermal growth factor receptor signaling pathway|regulation of proteasomal protein catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity			ovary(1)|pancreas(1)	2		all_cancers(16;2.56e-05)|all_epithelial(16;0.000116)|Hepatocellular(780;0.0068)|Lung NSC(18;0.0795)|all_lung(18;0.159)				TCCACCGTCTCATGCTGCGAG	0.657		NaN											0	0	0	1	0	28	49				
HBQ1	3049	broad.mit.edu	37	16	230775	230776	+	Missense_Mutation	DNP	TC	TC	AA			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:230775_230776TC>AA	uc002cfz.2	+	2	357_358	c.206_207TC>AA	c.(205-207)CTC>CAA	p.L69Q		NM_005331	NP_005322	P09105	HBAT_HUMAN	theta 1 globin	69						hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity				0		all_cancers(16;2.03e-06)|all_epithelial(16;5.16e-06)|Hepatocellular(16;0.000325)|Lung NSC(18;0.0138)|all_lung(18;0.0306)				GCGCTGAGCCTCGCCGTGGAGC	0.698		NaN											0	0	0	1	0	3	12				
PIGQ	9091	broad.mit.edu	37	16	632999	632999	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:632999C>T	uc002cho.2	+	10	1750	c.1648C>T	c.(1648-1650)CTA>TTA	p.L550L	PIGQ_uc010bqw.2_Silent_p.I570I|PIGQ_uc002chn.2_Silent_p.I570I|PIGQ_uc010uui.1_3'UTR|PIGQ_uc002chp.2_Silent_p.L120L|uc010uuj.1_3'UTR	NM_148920	NP_683721	Q9BRB3	PIGQ_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	550					C-terminal protein lipidation|carbohydrate metabolic process|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			central_nervous_system(1)	1		Hepatocellular(780;0.00335)				GGGAGCTCATCTACCCCTGGA	0.672		NaN											0	0	0	1	0	57	72				
FAM195A	84331	broad.mit.edu	37	16	697470	697470	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:697470C>T	uc002cic.1	+	3	379	c.236C>T	c.(235-237)ACG>ATG	p.T79M	FAM195A_uc002cid.1_Intron|FAM195A_uc002cie.2_Missense_Mutation_p.R8C|FAM195A_uc002cif.1_RNA|WDR90_uc002cig.1_5'Flank|WDR90_uc002cih.1_5'Flank|WDR90_uc002cii.1_5'Flank|WDR90_uc002cij.1_5'Flank	NM_138418	NP_612427	Q9BUT9	F195A_HUMAN	hypothetical protein LOC84331	79											0						GCCCCCTCCACGTCCCCATCC	0.647		NaN											0	0	0	1	0	20	14				
PKD1	5310	broad.mit.edu	37	16	2153270	2153270	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:2153270C>A	uc002cos.1	-	23	8997	c.8788G>T	c.(8788-8790)GAC>TAC	p.D2930Y	PKD1_uc002cot.1_Missense_Mutation_p.D2930Y|PKD1_uc010bse.1_RNA	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	2930	Extracellular (Potential).				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						CACGCACCGTCCAGCAGCGTA	0.647		NaN											1	0	1.85244e-09	1	1.9727e-09	25	12				
PKD1	5310	broad.mit.edu	37	16	2153839	2153839	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:2153839C>T	uc002cos.1	-	23	8428	c.8219G>A	c.(8218-8220)GGA>GAA	p.G2740E	PKD1_uc002cot.1_Missense_Mutation_p.G2740E|PKD1_uc010bse.1_RNA	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	2740	Extracellular (Potential).|REJ.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						TGACTCGGCTCCCAGCTCTGA	0.597		NaN											0	0	0	1	0	13	4				
MMP25	64386	broad.mit.edu	37	16	3100351	3100351	+	Silent	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:3100351C>G	uc002cth.2	+	4	702	c.465C>G	c.(463-465)CTC>CTG	p.L155L	MMP25_uc002cti.1_Silent_p.L91L	NM_022468	NP_071913	Q9NPA2	MMP25_HUMAN	matrix metalloproteinase 25 preproprotein	155					inflammatory response|proteolysis	anchored to membrane|cell surface|plasma membrane|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0						AGTCAGGCCTCACATTTCATG	0.637		NaN											0	0	0	1	0	15	35				
TXNDC11	51061	broad.mit.edu	37	16	11773080	11773080	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:11773080C>G	uc010buu.1	-	13	2991	c.2929G>C	c.(2929-2931)GAA>CAA	p.E977Q	TXNDC11_uc002dbg.1_Missense_Mutation_p.E950Q	NM_015914	NP_056998	Q6PKC3	TXD11_HUMAN	thioredoxin domain containing 11	977					cell redox homeostasis	endoplasmic reticulum membrane|integral to membrane					0						TTATTCCTTTCAGACACCAGT	0.478		NaN											0	0	0	1	0	14	44				
NOMO3	408050	broad.mit.edu	37	16	16349968	16349968	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:16349968C>T	uc002deq.2	+	11	1308	c.1173C>T	c.(1171-1173)ATC>ATT	p.I391I	NOMO3_uc002dep.2_Silent_p.I391I|NOMO3_uc010bvp.1_Silent_p.I224I	NM_001004067	NP_001004067	P69849	NOMO3_HUMAN	nodal modulator 3 precursor	391	Extracellular (Potential).					integral to membrane	carbohydrate binding|carboxypeptidase activity				0				UCEC - Uterine corpus endometrioid carcinoma (3;0.123)		CGGTCACCATCAAAATTGCAC	0.468		NaN											0	0	0	1	0	40	119				
DNAH3	55567	broad.mit.edu	37	16	20998710	20998710	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:20998710G>C	uc010vbe.1	-	47	6943	c.6943C>G	c.(6943-6945)CTG>GTG	p.L2315V	DNAH3_uc010vbd.1_5'Flank	NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	2315					ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		TTGTCAATCAGACGATCATAG	0.413		NaN											0	0	0	1	0	42	75				
DNAH3	55567	broad.mit.edu	37	16	21065842	21065842	+	Missense_Mutation	SNP	T	T	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:21065842T>A	uc010vbe.1	-	28	3938	c.3938A>T	c.(3937-3939)AAG>ATG	p.K1313M		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	1313	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		ATCATTGCTCTTTTTCAGAAA	0.537		NaN											0	0	0	1	0	9	30				
IL21R	50615	broad.mit.edu	37	16	27456025	27456025	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:27456025C>A	uc002doq.1	+	6	903	c.670C>A	c.(670-672)CAG>AAG	p.Q224K	IL21R_uc002dor.1_Missense_Mutation_p.Q224K|IL21R_uc002dos.1_Missense_Mutation_p.Q224K	NM_181078	NP_851564	Q9HBE5	IL21R_HUMAN	interleukin 21 receptor precursor	224	Extracellular (Potential).				natural killer cell activation	integral to membrane	interleukin-21 receptor activity			ovary(2)|lung(1)|breast(1)	4						GGTCATCTTTCAGACCCAGTC	0.582		NaN	T	BCL6	NHL								1	0	0.000673444	1	0.000684208	11	40				
PRRT2	112476	broad.mit.edu	37	16	29824976	29824976	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:29824976C>T	uc002due.3	+	2	902	c.601C>T	c.(601-603)CAC>TAC	p.H201Y	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|uc002duc.1_5'Flank|PRRT2_uc002dud.2_Missense_Mutation_p.H201Y|PRRT2_uc002duf.1_Missense_Mutation_p.H201Y|C16orf53_uc002dug.3_5'Flank	NM_145239	NP_660282	Q7Z6L0	PRRT2_HUMAN	proline-rich transmembrane protein 2	201	Extracellular (Potential).|Pro-rich.				response to biotic stimulus	integral to membrane					0						CCCTGAGCCTCACTCACCACC	0.612		NaN											0	0	0	1	0	7	11				
PPP4C	5531	broad.mit.edu	37	16	30096314	30096314	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:30096314C>G	uc002dwe.2	+	9	999	c.855C>G	c.(853-855)ATC>ATG	p.I285M	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|PPP4C_uc002dwf.2_Missense_Mutation_p.I285M|PPP4C_uc002dwg.2_RNA|PPP4C_uc002dwh.2_Missense_Mutation_p.I206M	NM_002720	NP_002711	P60510	PP4C_HUMAN	protein phosphatase 4, catalytic subunit	285					microtubule cytoskeleton organization|regulation of double-strand break repair via homologous recombination	centrosome|nucleus	metal ion binding|NF-kappaB-inducing kinase activity|protein binding|protein serine/threonine phosphatase activity			skin(1)	1						ATTTCATCATCTTTGAGGCTG	0.627		NaN											0	0	0	1	0	33	59				
ARMC5	79798	broad.mit.edu	37	16	31470893	31470893	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:31470893C>T	uc002ecc.2	+	1	577	c.48C>T	c.(46-48)CTC>CTT	p.L16L	ARMC5_uc010vfn.1_Silent_p.L111L|ARMC5_uc010vfo.1_Silent_p.L48L|ARMC5_uc002eca.3_Silent_p.L16L|ARMC5_uc010vfp.1_Silent_p.L16L|ARMC5_uc002ecb.2_Silent_p.L16L	NM_001105247	NP_001098717	Q96C12	ARMC5_HUMAN	armadillo repeat containing 5 isoform a	16							binding			pancreas(1)	1						CGTTCTGCCTCGCGCAGCTCG	0.716		NaN											0	0	0	1	0	5	8				
PHKB	5257	broad.mit.edu	37	16	47733202	47733202	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:47733202G>C	uc002eev.3	+	31	3259	c.3207G>C	c.(3205-3207)TTG>TTC	p.L1069F	PHKB_uc002eeu.3_Missense_Mutation_p.L1062F|PHKB_uc002eew.3_Missense_Mutation_p.L310F	NM_000293	NP_000284	Q93100	KPBB_HUMAN	phosphorylase kinase, beta isoform a	1069					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity			ovary(1)|large_intestine(1)|breast(1)	3		all_cancers(37;0.00447)|all_lung(18;0.00616)|Lung NSC(13;0.0418)|Breast(268;0.203)				GCAGCTATTTGACAAAGGCGG	0.463		NaN											0	0	0	1	0	26	90				
LONP2	83752	broad.mit.edu	37	16	48368170	48368170	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:48368170C>T	uc002efi.1	+	12	1928	c.1839C>T	c.(1837-1839)ATC>ATT	p.I613I	LONP2_uc010vgm.1_RNA|LONP2_uc002efj.1_Silent_p.I569I	NM_031490	NP_113678	Q86WA8	LONP2_HUMAN	peroxisomal LON protease-like	613					misfolded or incompletely synthesized protein catabolic process|protein targeting to peroxisome|signal peptide processing	nucleoid|peroxisomal matrix	ATP binding|ATP-dependent peptidase activity|enzyme binding|sequence-specific DNA binding|serine-type endopeptidase activity				0						CTGAATCTATCAGTGACACTA	0.393		NaN											0	0	0	1	0	24	77				
SALL1	6299	broad.mit.edu	37	16	51175982	51175982	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:51175982C>G	uc010vgs.1	-	2	182	c.151G>C	c.(151-153)GAG>CAG	p.E51Q	SALL1_uc010vgr.1_5'UTR|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	51					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			TCAAAGAACTCGGCACAGCAC	0.453		NaN											0	0	0	1	0	107	55				
OGFOD1	55239	broad.mit.edu	37	16	56504661	56504661	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:56504661G>A	uc002ejb.2	+	10	1344	c.1243G>A	c.(1243-1245)GAG>AAG	p.E415K	OGFOD1_uc002ejc.2_Missense_Mutation_p.E275K	NM_018233	NP_060703	Q8N543	OGFD1_HUMAN	2-oxoglutarate and iron-dependent oxygenase	415							iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			skin(1)	1					Vitamin C(DB00126)	ACAGAGCAATGAGCAGACAGA	0.438		NaN											0	0	0	1	0	3	14				
CNOT1	23019	broad.mit.edu	37	16	58565903	58565903	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:58565903T>C	uc002env.2	-	42	6429	c.6136A>G	c.(6136-6138)ATA>GTA	p.I2046V	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Missense_Mutation_p.I2041V|CNOT1_uc002ent.2_5'UTR|CNOT1_uc010vik.1_Missense_Mutation_p.I1003V	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	2046					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		GCAATAAATATCCGATGGGAA	0.423		NaN											0	0	0	1	0	99	33				
CMTM4	146223	broad.mit.edu	37	16	66651180	66651180	+	Nonstop_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:66651180C>G	uc002epz.2	-	5	887	c.705G>C	c.(703-705)TAG>TAC	p.*235Y	CMTM4_uc002eqa.2_3'UTR	NM_178818	NP_848933	Q8IZR5	CKLF4_HUMAN	chemokine-like factor superfamily 4 isoform 1	235					chemotaxis	extracellular space|integral to membrane	cytokine activity			pancreas(1)	1		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0811)|Epithelial(162;0.214)		CTGAACTTTTCTAGGCAAGTT	0.363		NaN											0	0	0	1	0	10	40				
DYNC1LI2	1783	broad.mit.edu	37	16	66783140	66783140	+	Silent	SNP	T	T	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:66783140T>A	uc002eqb.1	-	3	289	c.258A>T	c.(256-258)CTA>CTT	p.L86L	DYNC1LI2_uc010vis.1_Silent_p.L86L|DYNC1LI2_uc010vit.1_Silent_p.L86L|DYNC1LI2_uc010viu.1_Intron	NM_006141	NP_006132	O43237	DC1L2_HUMAN	dynein, cytoplasmic, light intermediate	86					transport	centrosome|cytoplasmic dynein complex|microtubule	ATP binding|motor activity			central_nervous_system(3)|skin(1)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0907)|Epithelial(162;0.212)		AGAGATATTCTAGGCCTCTTC	0.468		NaN											0	0	0	1	0	35	62				
ELMO3	79767	broad.mit.edu	37	16	67236431	67236431	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:67236431G>A	uc002esa.2	+	14	1595	c.1552G>A	c.(1552-1554)GAC>AAC	p.D518N	ELMO3_uc002esb.2_Missense_Mutation_p.D501N|ELMO3_uc002esc.2_Missense_Mutation_p.D352N|uc010vjf.1_5'Flank|MIR328_hsa-mir-328|MI0000804_5'Flank	NM_024712	NP_078988	Q96BJ8	ELMO3_HUMAN	engulfment and cell motility 3	465	ELMO.				apoptosis|phagocytosis	cytoplasm|cytoskeleton	SH3 domain binding				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00067)|Epithelial(162;0.00442)|all cancers(182;0.0417)		GGAGGACTTCGACAAGGTGGG	0.622		NaN											0	0	0	1	0	35	86				
FHOD1	29109	broad.mit.edu	37	16	67263797	67263797	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:67263797G>A	uc002esl.2	-	21	3423	c.3311C>T	c.(3310-3312)TCA>TTA	p.S1104L	LRRC29_uc002esf.2_5'Flank|LRRC29_uc002esg.2_5'Flank|LRRC29_uc010vjg.1_5'Flank|FHOD1_uc002esk.2_Missense_Mutation_p.S163L|FHOD1_uc010ced.2_Missense_Mutation_p.S911L	NM_013241	NP_037373	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	1104					actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(2)|ovary(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		GATCTCATCTGATGTATCACT	0.582		NaN											0	0	0	1	0	7	118				
FHOD1	29109	broad.mit.edu	37	16	67273347	67273347	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:67273347C>G	uc002esl.2	-	2	324	c.212G>C	c.(211-213)TGT>TCT	p.C71S	FHOD1_uc010ced.2_5'UTR|FHOD1_uc010vjh.1_5'UTR	NM_013241	NP_037373	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	71	GBD/FH3.				actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(2)|ovary(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		TTGCAGAGCACAATCCTCCAA	0.557		NaN											0	0	0	1	0	11	68				
COG8	84342	broad.mit.edu	37	16	69369059	69369059	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:69369059T>C	uc002ewy.2	-	3	849	c.778A>G	c.(778-780)ACT>GCT	p.T260A	COG8_uc002ewz.3_Missense_Mutation_p.T260A	NM_032382	NP_115758	Q96MW5	COG8_HUMAN	component of oligomeric golgi complex 8	260					protein transport	Golgi membrane|Golgi transport complex				ovary(1)	1						GGAATGGCAGTCAGGATGGAC	0.517		NaN											0	0	0	1	0	8	45				
SF3B3	23450	broad.mit.edu	37	16	70603923	70603923	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:70603923G>T	uc002ezf.2	+	24	3490	c.3279G>T	c.(3277-3279)ATG>ATT	p.M1093I		NM_012426	NP_036558	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3	1093					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(1)	1		Ovarian(137;0.0694)				AGGTGATCATGAACTACCATG	0.552		NaN											1	0	1.02788e-11	1	1.1109e-11	17	55				
ADAT1	23536	broad.mit.edu	37	16	75646313	75646313	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:75646313C>T	uc002feo.1	-	7	973	c.871G>A	c.(871-873)GGA>AGA	p.G291R	ADAT1_uc002fep.1_Missense_Mutation_p.G142R	NM_012091	NP_036223	Q9BUB4	ADAT1_HUMAN	adenosine deaminase, tRNA-specific 1	291	A to I editase.				tRNA processing		metal ion binding|RNA binding|tRNA-specific adenosine deaminase activity			ovary(1)|skin(1)	2						GTTCTGTCTCCACGGCCTGGC	0.587		NaN											0	0	0	1	0	17	77				
CNTNAP4	85445	broad.mit.edu	37	16	76556045	76556045	+	Silent	SNP	A	A	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:76556045A>G	uc002feu.1	+	19	3031	c.2646A>G	c.(2644-2646)GAA>GAG	p.E882E	CNTNAP4_uc002fev.1_Silent_p.E746E|CNTNAP4_uc010chb.1_Silent_p.E809E|CNTNAP4_uc002fex.1_Silent_p.E885E	NM_033401	NP_207837	Q9C0A0	CNTP4_HUMAN	cell recognition protein CASPR4 isoform 1	882	Extracellular (Potential).|Laminin G-like 3.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(1)|pancreas(1)	2						TGAGGGTTGAAAGGAACATGA	0.522		NaN											0	0	0	1	0	48	139				
ATMIN	23300	broad.mit.edu	37	16	81077671	81077671	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:81077671C>G	uc002ffz.1	+	4	1586	c.1568C>G	c.(1567-1569)TCA>TGA	p.S523*	ATMIN_uc002fga.2_Nonsense_Mutation_p.S365*|ATMIN_uc010vnn.1_Nonsense_Mutation_p.S294*|ATMIN_uc002fgb.1_Nonsense_Mutation_p.S365*	NM_015251	NP_056066	O43313	ATMIN_HUMAN	ATM interactor	523					response to DNA damage stimulus	nucleus	zinc ion binding				0						AGTGTTCATTCATCATATAAT	0.393		NaN											0	0	0	1	0	26	66				
ATMIN	23300	broad.mit.edu	37	16	81078172	81078172	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:81078172G>A	uc002ffz.1	+	4	2087	c.2069G>A	c.(2068-2070)GGA>GAA	p.G690E	ATMIN_uc002fga.2_Missense_Mutation_p.G532E|ATMIN_uc010vnn.1_Missense_Mutation_p.G461E|ATMIN_uc002fgb.1_Missense_Mutation_p.G532E	NM_015251	NP_056066	O43313	ATMIN_HUMAN	ATM interactor	690					response to DNA damage stimulus	nucleus	zinc ion binding				0						GGGTGTAGGGGAAATTCTAAC	0.468		NaN											0	0	0	1	0	93	217				
ATMIN	23300	broad.mit.edu	37	16	81078303	81078303	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:81078303G>T	uc002ffz.1	+	4	2218	c.2200G>T	c.(2200-2202)GAT>TAT	p.D734Y	ATMIN_uc002fga.2_Missense_Mutation_p.D576Y|ATMIN_uc010vnn.1_Missense_Mutation_p.D505Y|ATMIN_uc002fgb.1_Missense_Mutation_p.D576Y	NM_015251	NP_056066	O43313	ATMIN_HUMAN	ATM interactor	734					response to DNA damage stimulus	nucleus	zinc ion binding				0						CGTGAGTACTGATTCATCTGA	0.428		NaN											1	0	3.76114e-14	1	4.10857e-14	37	221				
ATMIN	23300	broad.mit.edu	37	16	81078383	81078383	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:81078383G>A	uc002ffz.1	+	4	2298	c.2280G>A	c.(2278-2280)TTG>TTA	p.L760L	ATMIN_uc002fga.2_Silent_p.L602L|ATMIN_uc010vnn.1_Silent_p.L531L|ATMIN_uc002fgb.1_Silent_p.L602L	NM_015251	NP_056066	O43313	ATMIN_HUMAN	ATM interactor	760					response to DNA damage stimulus	nucleus	zinc ion binding				0						AAGTTCAGTTGAACAGTACAG	0.448		NaN											0	0	0	1	0	46	141				
KIAA0513	9764	broad.mit.edu	37	16	85100813	85100813	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:85100813G>C	uc002fiu.2	+	2	356	c.136G>C	c.(136-138)GAG>CAG	p.E46Q	KIAA0513_uc002fis.3_Missense_Mutation_p.E46Q|KIAA0513_uc010voj.1_Missense_Mutation_p.E46Q|KIAA0513_uc002fit.2_Missense_Mutation_p.E46Q	NM_014732	NP_055547	O60268	K0513_HUMAN	hypothetical protein LOC9764	46						cytoplasm				breast(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.234)		ATCAGAGAGTGAGACCACTGA	0.647		NaN											0	0	0	1	0	15	46				
FBXO31	79791	broad.mit.edu	37	16	87365010	87365010	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:87365010C>G	uc002fjw.2	-	9	1548	c.1504G>C	c.(1504-1506)GAG>CAG	p.E502Q	FBXO31_uc010vot.1_Missense_Mutation_p.E330Q|FBXO31_uc002fjv.2_Missense_Mutation_p.E394Q	NM_024735	NP_079011	Q5XUX0	FBX31_HUMAN	F-box protein 31	502					cell cycle|cyclin catabolic process|mitotic cell cycle G1/S transition DNA damage checkpoint|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	SCF ubiquitin ligase complex	cyclin binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0272)		GATTTCAGCTCCAGCCAGACG	0.622		NaN											0	0	0	1	0	14	24				
ZFPM1	161882	broad.mit.edu	37	16	88594547	88594547	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:88594547G>T	uc002fkv.2	+	6	646	c.613G>T	c.(613-615)GAG>TAG	p.E205*		NM_153813	NP_722520	Q8IX07	FOG1_HUMAN	zinc finger protein, multitype 1	205					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|transcription factor binding|zinc ion binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0478)		TGTGAAGAAGGAGCCAGCAGA	0.697		NaN											1	0	0.014758	1	0.0148163	4	11				
ZFPM1	161882	broad.mit.edu	37	16	88594556	88594556	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:88594556G>C	uc002fkv.2	+	6	655	c.622G>C	c.(622-624)GAG>CAG	p.E208Q		NM_153813	NP_722520	Q8IX07	FOG1_HUMAN	zinc finger protein, multitype 1	208					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	DNA binding|transcription factor binding|zinc ion binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0478)		GGAGCCAGCAGAGCCCACGTG	0.692		NaN											0	0	0	1	0	3	14				
CDT1	81620	broad.mit.edu	37	16	88871024	88871024	+	Missense_Mutation	SNP	A	A	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:88871024A>C	uc002flu.2	+	2	354	c.300A>C	c.(298-300)AAA>AAC	p.K100N		NM_030928	NP_112190	Q9H211	CDT1_HUMAN	chromatin licensing and DNA replication factor	100					DNA replication|DNA replication checkpoint|M/G1 transition of mitotic cell cycle|regulation of DNA-dependent DNA replication initiation|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle	cytosol|nucleoplasm	DNA binding|protein binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(80;0.0476)		AGATAAAGAAATCCACCCCGG	0.687		NaN											0	0	0	1	0	20	28				
ANKRD11	29123	broad.mit.edu	37	16	89348054	89348054	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:89348054C>G	uc002fmx.1	-	9	5357	c.4896G>C	c.(4894-4896)AAG>AAC	p.K1632N	ANKRD11_uc002fmy.1_Missense_Mutation_p.K1632N|ANKRD11_uc002fnc.1_Missense_Mutation_p.K1632N|ANKRD11_uc002fna.1_5'Flank|ANKRD11_uc002fnb.1_Missense_Mutation_p.K1589N	NM_013275	NP_037407	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1632	Lys-rich.					nucleus				ovary(4)|large_intestine(1)|central_nervous_system(1)	6		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		CCAGACCCTTCTTCCGCCCGT	0.572		NaN											0	0	0	1	0	10	126				
ZNF276	92822	broad.mit.edu	37	16	89799709	89799709	+	Splice_Site	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:89799709G>C	uc002fos.3	+	7	1267	c.1170_splice	c.e7-1	p.K390_splice	ZNF276_uc010ciq.2_Splice_Site_p.K176_splice|ZNF276_uc002fop.2_Splice_Site_p.K298_splice|ZNF276_uc002foq.3_Splice_Site_p.K315_splice|ZNF276_uc010cir.2_Splice_Site|ZNF276_uc002for.3_Splice_Site_p.K176_splice|ZNF276_uc010cis.2_Splice_Site_p.K149_splice|ZNF276_uc002fot.3_Splice_Site|ZNF276_uc010vpm.1_Splice_Site_p.K228_splice|ZNF276_uc010cit.1_Splice_Site_p.K149_splice	NM_001113525	NP_001106997	Q8N554	ZN276_HUMAN	zinc finger protein 276 isoform a						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		CTTTTTTTCAGAGTCTCTGGT	0.428		NaN											0	0	0	1	0	31	111				
FANCA	2175	broad.mit.edu	37	16	89838145	89838145	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr16:89838145C>T	uc002fou.1	-	23	2134	c.2092G>A	c.(2092-2094)GAG>AAG	p.E698K	FANCA_uc010vpn.1_Missense_Mutation_p.E698K	NM_000135	NP_000126	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A isoform	698					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		TTTGATATCTCAACGCTGCTG	0.517		NaN	D|Mis|N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	1	0	29	64				
PRPF8	10594	broad.mit.edu	37	17	1564436	1564436	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:1564436G>A	uc002fte.2	-	28	4473	c.4359C>T	c.(4357-4359)TTC>TTT	p.F1453F		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	1453						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		GTGTCCACCAGAACGGATTCT	0.547		NaN											0	0	0	1	0	44	4				
PRPF8	10594	broad.mit.edu	37	17	1564447	1564447	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:1564447G>C	uc002fte.2	-	28	4462	c.4348C>G	c.(4348-4350)CAG>GAG	p.Q1450E		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	1450						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		AACGGATTCTGCTTCAAAACC	0.542		NaN											0	0	0	1	0	45	5				
PRPF8	10594	broad.mit.edu	37	17	1564634	1564634	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:1564634G>A	uc002fte.2	-	27	4383	c.4269C>T	c.(4267-4269)TTC>TTT	p.F1423F		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	1423						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		GGTCCTTCTGGAAGAGGGTAT	0.458		NaN											0	0	0	1	0	101	11				
PRPF8	10594	broad.mit.edu	37	17	1564962	1564962	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:1564962G>C	uc002fte.2	-	26	4259	c.4145C>G	c.(4144-4146)TCT>TGT	p.S1382C		NM_006445	NP_006436	Q6P2Q9	PRP8_HUMAN	U5 snRNP-specific protein	1382						catalytic step 2 spliceosome|nuclear speck|U5 snRNP	protein binding|RNA binding			lung(4)|ovary(2)	6				UCEC - Uterine corpus endometrioid carcinoma (25;0.0855)		GACCCGCTGAGAATCAATGAA	0.552		NaN											0	0	0	1	0	47	6				
OR1E2	8388	broad.mit.edu	37	17	3336869	3336869	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:3336869G>C	uc010vre.1	-	1	267	c.267C>G	c.(265-267)GAC>GAG	p.D89E		NM_003554	NP_003545	P47887	OR1E2_HUMAN	olfactory receptor, family 1, subfamily E,	89	Extracellular (Potential).				sensory perception of smell	integral to plasma membrane	olfactory receptor activity			large_intestine(1)	1						GGATGGATGGGTCTTGGTTCT	0.483		NaN											0	0	0	1	0	19	26				
ZZEF1	23140	broad.mit.edu	37	17	3992006	3992006	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:3992006G>A	uc002fxe.2	-	13	2271	c.2207C>T	c.(2206-2208)ACC>ATC	p.T736I	ZZEF1_uc002fxk.1_Missense_Mutation_p.T736I	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	736							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						AAACTGAAGGGTCCTGAGGAG	0.527		NaN											0	0	0	1	0	5	25				
ZZEF1	23140	broad.mit.edu	37	17	4013096	4013096	+	Silent	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:4013096G>C	uc002fxe.2	-	6	1192	c.1128C>G	c.(1126-1128)CTC>CTG	p.L376L	ZZEF1_uc002fxk.1_Silent_p.L376L	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	376	DOC.						calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						CAACAGCCCTGAGACCATGAA	0.443		NaN											0	0	0	1	0	12	43				
UBE2G1	7326	broad.mit.edu	37	17	4200037	4200037	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:4200037G>A	uc002fxs.2	-	3	580	c.222C>T	c.(220-222)TTC>TTT	p.F74F		NM_003342	NP_003333	P62253	UB2G1_HUMAN	ubiquitin-conjugating enzyme E2G 1	74					protein K48-linked ubiquitination|protein K63-linked ubiquitination|ubiquitin-dependent protein catabolic process		ATP binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity				0						TTTCTGTAATGAATTTCATTT	0.348		NaN											0	0	0	1	0	126	17				
MYBBP1A	10514	broad.mit.edu	37	17	4457360	4457360	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:4457360T>C	uc002fyb.3	-	4	469	c.407A>G	c.(406-408)AAC>AGC	p.N136S	MYBBP1A_uc002fxz.3_Missense_Mutation_p.N136S	NM_014520	NP_055335	Q9BQG0	MBB1A_HUMAN	MYB binding protein 1a isoform 2	136	Interaction with MYB (By similarity).				nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			ovary(1)|skin(1)	2						TCCAAACAGGTTTGCAAAGAG	0.592		NaN											0	0	0	1	0	47	8				
SMTNL2	342527	broad.mit.edu	37	17	4498617	4498617	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:4498617C>T	uc002fyf.1	+	5	1051	c.984C>T	c.(982-984)GCC>GCT	p.A328A	SMTNL2_uc002fye.2_Silent_p.A184A	NM_001114974	NP_001108446	Q2TAL5	SMTL2_HUMAN	smoothelin-like 2 isoform 1	328											0				READ - Rectum adenocarcinoma(115;0.0325)		AAACGGCGGCCGGCAAGTACG	0.677		NaN											0	0	0	1	0	3	26				
TP53	7157	broad.mit.edu	37	17	7577099	7577099	+	Missense_Mutation	SNP	C	C	G	rs121912660		TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:7577099C>G	uc002gim.2	-	8	1033	c.839G>C	c.(838-840)AGA>ACA	p.R280T	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.R280T|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R148T|TP53_uc010cng.1_Missense_Mutation_p.R148T|TP53_uc002gii.1_Missense_Mutation_p.R148T|TP53_uc010cnh.1_Missense_Mutation_p.R280T|TP53_uc010cni.1_Missense_Mutation_p.R280T|TP53_uc002gij.2_Missense_Mutation_p.R280T	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	280	Interaction with DNA.||Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> T (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> K (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in a sporadic cancer; somatic mutation).|R -> I (in sporadic cancers; somatic mutation).|R -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R280T(53)|p.R280K(41)|p.R280G(18)|p.R280S(13)|p.R280I(12)|p.R280*(8)|p.R280fs*65(7)|p.0?(7)|p.R280R(3)|p.?(2)|p.R280_D281delRD(2)|p.A276_R283delACPGRDRR(1)|p.A276fs*64(1)|p.G279_R280delGR(1)|p.R280fs*62(1)|p.S269fs*21(1)|p.G279fs*59(1)|p.F270_D281del12(1)|p.C275_R283delCACPGRDRR(1)|p.L265_K305del41(1)|p.D281fs*24(1)|p.V272_K292del21(1)|p.C275fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCGCCGGTCTCTCCCAGGACA	0.542		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	1	0	31	3		Valid		
PFAS	5198	broad.mit.edu	37	17	8157482	8157482	+	Splice_Site	SNP	A	A	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:8157482A>C	uc002gkr.2	+	3	284	c.143_splice	c.e3-2	p.A48_splice	PFAS_uc010vuv.1_Splice_Site	NM_012393	NP_036525	O15067	PUR4_HUMAN	phosphoribosylformylglycinamidine synthase						'de novo' IMP biosynthetic process|glutamine metabolic process|purine base metabolic process	cytosol	ATP binding|phosphoribosylformylglycinamidine synthase activity|protein binding			ovary(2)|central_nervous_system(2)|pancreas(1)	5					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GTCTCCCTGCAGCTGAGGCCC	0.582		NaN											0	0	0	1	0	20	16				
PIK3R5	23533	broad.mit.edu	37	17	8808182	8808182	+	Silent	SNP	G	G	A	rs144885920		TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:8808182G>A	uc002glt.2	-	5	391	c.324C>T	c.(322-324)ACC>ACT	p.T108T	PIK3R5_uc010vuz.1_Silent_p.T108T|PIK3R5_uc002glu.3_5'UTR|PIK3R5_uc010coa.1_Silent_p.T108T|PIK3R5_uc010cob.1_5'UTR	NM_014308	NP_055123	Q8WYR1	PI3R5_HUMAN	phosphoinositide-3-kinase, regulatory subunit 5	108					platelet activation	cytosol|membrane|nucleus				breast(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5						ACCGGTGGTAGGTGCTGGCTG	0.552		NaN											0	0	0	1	0	10	28				
MYH4	4622	broad.mit.edu	37	17	10362679	10362679	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:10362679G>C	uc002gmn.2	-	15	1587	c.1476C>G	c.(1474-1476)TTC>TTG	p.F492L	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	492	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						TGTGGTGGTTGAAAAACTGTT	0.473		NaN											0	0	0	1	0	26	64				
MYO15A	51168	broad.mit.edu	37	17	18045033	18045033	+	Silent	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:18045033G>C	uc010vxh.1	+	22	5936	c.5598G>C	c.(5596-5598)CTG>CTC	p.L1866L		NM_016239	NP_057323	Q9UKN7	MYO15_HUMAN	myosin XV	1866	Myosin head-like.				sensory perception of sound	cytoplasm|myosin complex|stereocilium	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|pancreas(1)|breast(1)|central_nervous_system(1)	9	all_neural(463;0.228)					TGTCAGTGCTGAGTCGCCTGT	0.582		NaN									OREG0024223	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	32	28				
EPN2	22905	broad.mit.edu	37	17	19235231	19235231	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:19235231C>G	uc002gvd.3	+	10	1925	c.1477C>G	c.(1477-1479)CAA>GAA	p.Q493E	EPN2_uc010cql.1_Missense_Mutation_p.Q202E|EPN2_uc002gve.3_Missense_Mutation_p.Q436E|EPN2_uc002gvf.3_Missense_Mutation_p.Q208E|EPN2_uc010vyo.1_Missense_Mutation_p.Q201E|EPN2_uc010vyp.1_Missense_Mutation_p.Q429E|EPN2_uc010vyq.1_Missense_Mutation_p.Q430E|EPN2_uc002gvh.1_Intron|EPN2_uc002gvj.3_Missense_Mutation_p.Q156E	NM_014964	NP_055779	O95208	EPN2_HUMAN	epsin 2 isoform b	493	6 X 3 AA repeats of [DE]-P-W.				endocytosis		lipid binding			skin(1)	1	all_cancers(12;3.11e-05)|all_epithelial(12;0.00121)|Hepatocellular(7;0.00345)|Breast(13;0.143)					CTTTGAGTCTCAACCCCTGAC	0.572		NaN											0	0	0	1	0	33	134				
CCDC144NL	339184	broad.mit.edu	37	17	20768765	20768765	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:20768765C>A	uc002gyf.2	-	4	749	c.629G>T	c.(628-630)AGA>ATA	p.R210I	uc002gyg.1_5'Flank|uc002gyh.1_5'Flank	NM_001004306	NP_001004306	Q6NUI1	C144L_HUMAN	coiled-coil domain containing 144 family,	210											0						CTTCCCCTTTCTTTTTCCTCT	0.368		NaN											1	0	1.60099e-16	1	1.76978e-16	36	45				
CCDC144NL	339184	broad.mit.edu	37	17	20796765	20796765	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:20796765G>C	uc002gyf.2	-	2	475	c.355C>G	c.(355-357)CTA>GTA	p.L119V	uc002gyg.1_Intron|uc002gyh.1_Intron	NM_001004306	NP_001004306	Q6NUI1	C144L_HUMAN	coiled-coil domain containing 144 family,	119											0						TCAGGAACTAGTTGCTGAATG	0.249		NaN											0	0	0	1	0	33	30				
SLC13A2	9058	broad.mit.edu	37	17	26824194	26824194	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:26824194C>T	uc002hbh.2	+	12	1753	c.1686C>T	c.(1684-1686)CTC>CTT	p.L562L	SLC13A2_uc010wam.1_Silent_p.L518L|SLC13A2_uc010wan.1_Silent_p.L611L|SLC13A2_uc010wao.1_Silent_p.L519L|SLC13A2_uc002hbi.2_Silent_p.L491L	NM_003984	NP_003975	Q13183	S13A2_HUMAN	solute carrier family 13, member 2 isoform b	562	Helical; (Potential).					integral to plasma membrane|membrane fraction	low affinity sodium:dicarboxylate symporter activity				0	all_lung(13;0.000871)|Lung NSC(42;0.0027)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)	Succinic acid(DB00139)	GCATCCCCCTCTTCAGCCTGC	0.612		NaN											0	0	0	1	0	60	87				
PHF12	57649	broad.mit.edu	37	17	27246266	27246266	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:27246266C>G	uc002hdg.1	-	6	1394	c.864G>C	c.(862-864)CAG>CAC	p.Q288H	PHF12_uc010wbb.1_Missense_Mutation_p.Q270H|PHF12_uc002hdi.1_Missense_Mutation_p.Q284H|PHF12_uc002hdj.1_Missense_Mutation_p.Q288H|PHF12_uc010crw.1_5'UTR|PHF12_uc002hdh.1_Missense_Mutation_p.Q71H	NM_001033561	NP_001028733	Q96QT6	PHF12_HUMAN	PHD finger protein 12 isoform 1	288	PHD-type 2; atypical.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	transcriptional repressor complex	protein binding|zinc ion binding			ovary(1)	1	all_cancers(5;1.95e-14)|all_epithelial(6;5e-18)|Lung NSC(42;0.01)		Epithelial(11;1.64e-05)|all cancers(11;7.47e-05)|BRCA - Breast invasive adenocarcinoma(11;9.79e-05)			AATAGTCACACTGGATGAGAG	0.502		NaN											0	0	0	1	0	7	29				
ABHD15	116236	broad.mit.edu	37	17	27893107	27893107	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:27893107C>A	uc002hed.1	-	1	942	c.878G>T	c.(877-879)AGC>ATC	p.S293I	TP53I13_uc002hee.2_5'Flank	NM_198147	NP_937790	Q6UXT9	ABH15_HUMAN	abhydrolase domain containing 15 precursor	293						extracellular region	carboxylesterase activity				0						TACCCACCTGCTGAGGGCGAT	0.617		NaN											1	0	1.33834e-09	1	1.42971e-09	16	49				
EFCAB5	374786	broad.mit.edu	37	17	28380875	28380875	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:28380875G>T	uc002het.2	+	10	2095	c.1903G>T	c.(1903-1905)GAA>TAA	p.E635*	EFCAB5_uc010wbi.1_Nonsense_Mutation_p.E378*|EFCAB5_uc010wbj.1_Nonsense_Mutation_p.E579*|EFCAB5_uc010wbk.1_Nonsense_Mutation_p.E292*|EFCAB5_uc010csd.2_RNA|EFCAB5_uc010cse.2_Nonsense_Mutation_p.E514*|EFCAB5_uc010csf.2_Nonsense_Mutation_p.E514*	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	635							calcium ion binding			ovary(1)|skin(1)	2						GTCAGCTGCAGAACAGGGATC	0.443		NaN											1	0	8.04996e-18	1	8.92782e-18	23	101				
MYO1D	4642	broad.mit.edu	37	17	30986161	30986161	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:30986161C>G	uc002hho.1	-	17	2329	c.2317G>C	c.(2317-2319)GAG>CAG	p.E773Q	MYO1D_uc002hhp.1_Missense_Mutation_p.E773Q	NM_015194	NP_056009	O94832	MYO1D_HUMAN	myosin ID	773						myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)			AGGGCCTCCTCAAAACGGCGA	0.517		NaN									OREG0024311	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	15	65				
MYO1D	4642	broad.mit.edu	37	17	30986208	30986208	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:30986208C>A	uc002hho.1	-	17	2282	c.2270G>T	c.(2269-2271)GGG>GTG	p.G757V	MYO1D_uc002hhp.1_Missense_Mutation_p.G757V	NM_015194	NP_056009	O94832	MYO1D_HUMAN	myosin ID	757						myosin complex	actin binding|ATP binding|calmodulin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)	3			BRCA - Breast invasive adenocarcinoma(9;0.0362)			CACGTGCTTCCCGTAGTCTCG	0.537		NaN									OREG0024311	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	1.85244e-09	1	1.9727e-09	23	93				
SLFN12	55106	broad.mit.edu	37	17	33749640	33749640	+	Silent	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:33749640G>C	uc002hji.3	-	2	785	c.408C>G	c.(406-408)GTC>GTG	p.V136V	SLFN12_uc002hjj.3_Silent_p.V136V|SLFN12_uc010cts.2_Silent_p.V136V	NM_018042	NP_060512	Q8IYM2	SLN12_HUMAN	schlafen family member 12	136							ATP binding			skin(1)	1		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		TGGCATTCATGACTTTTGCAG	0.428		NaN											0	0	0	1	0	22	54				
ACACA	31	broad.mit.edu	37	17	35468485	35468485	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:35468485G>C	uc002hnm.2	-	52	6626	c.6435C>G	c.(6433-6435)ATC>ATG	p.I2145M	ACACA_uc002hnk.2_Missense_Mutation_p.I2067M|ACACA_uc002hnl.2_Missense_Mutation_p.I2087M|ACACA_uc002hnn.2_Missense_Mutation_p.I2145M|ACACA_uc002hno.2_Missense_Mutation_p.I2182M|ACACA_uc010cuy.2_Missense_Mutation_p.I790M|ACACA_uc010wdb.1_Missense_Mutation_p.I183M|ACACA_uc010wdc.1_Missense_Mutation_p.I271M	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	2145	Carboxyltransferase.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	CAGCCAAGTGGATGTAGACTG	0.502		NaN											0	0	0	1	0	29	47				
TADA2A	6871	broad.mit.edu	37	17	35800675	35800675	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:35800675C>T	uc002hnt.2	+	6	511	c.354C>T	c.(352-354)TTC>TTT	p.F118F	TADA2A_uc002hnu.1_Silent_p.F118F|TADA2A_uc002hnv.2_Silent_p.F118F|TADA2A_uc010wdd.1_Silent_p.F118F|TADA2A_uc002hnw.2_Silent_p.F17F|TADA2A_uc010cvb.2_5'UTR	NM_001488	NP_001479	O75478	TAD2A_HUMAN	transcriptional adaptor 2A isoform a	118	SANT.				histone H3 acetylation|transcription from RNA polymerase II promoter	chromosome|PCAF complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|zinc ion binding			breast(3)|skin(1)	4						TGAAGCATTTCATCAATAACC	0.458		NaN											0	0	0	1	0	12	39				
SOCS7	30837	broad.mit.edu	37	17	36523881	36523881	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:36523881C>T	uc002hqa.2	+	6	1431	c.1308C>T	c.(1306-1308)CTC>CTT	p.L436L	SOCS7_uc010cvl.2_Silent_p.L402L|SOCS7_uc002hqb.2_RNA	NM_014598	NP_055413	O14512	SOCS7_HUMAN	suppressor of cytokine signaling 7	436	Mediates interaction with SORBS3.|SH2.				intracellular signal transduction|negative regulation of signal transduction|regulation of growth	cytoplasm|nucleus|plasma membrane	protein binding|SH3 domain binding			skin(1)	1	Breast(7;3.47e-17)					TCCTGAGCCTCAGTTTCCGAT	0.483		NaN											0	0	0	1	0	17	42				
IKZF3	22806	broad.mit.edu	37	17	37949123	37949123	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:37949123G>A	uc002hsu.2	-	4	289	c.227C>T	c.(226-228)CCC>CTC	p.P76L	IKZF3_uc002htd.2_Missense_Mutation_p.P42L|IKZF3_uc010cwd.2_Intron|IKZF3_uc002hsv.2_Missense_Mutation_p.P42L|IKZF3_uc010cwe.2_Missense_Mutation_p.P76L|IKZF3_uc010cwf.2_Intron|IKZF3_uc010cwg.2_Intron|IKZF3_uc002hsw.2_Missense_Mutation_p.P76L|IKZF3_uc002hsx.2_Missense_Mutation_p.P76L|IKZF3_uc002hsy.2_Missense_Mutation_p.P76L|IKZF3_uc002hsz.2_Missense_Mutation_p.P76L|IKZF3_uc002hta.2_Missense_Mutation_p.P76L|IKZF3_uc002htb.2_RNA|IKZF3_uc010cwh.2_Intron|IKZF3_uc002htc.2_5'UTR	NM_012481	NP_036613	Q9UKT9	IKZF3_HUMAN	aiolos isoform 1	76					B cell activation|mesoderm development|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(2)|kidney(2)|skin(2)	6	Breast(7;4.5e-103)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			ATTTCCCATGGGTTCTGACTT	0.353		NaN											0	0	0	1	0	29	47				
HCRT	3060	broad.mit.edu	37	17	40336367	40336367	+	Silent	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:40336367G>C	uc002hzc.1	-	2	288	c.201C>G	c.(199-201)GGC>GGG	p.G67G		NM_001524	NP_001515	O43612	OREX_HUMAN	orexin precursor	67					neuropeptide signaling pathway	cell junction|extracellular region|rough endoplasmic reticulum|synaptic vesicle					0		all_cancers(22;1.39e-06)|all_epithelial(22;9.98e-06)|Breast(137;0.000143)|Ovarian(249;0.0221)|Myeloproliferative disorder(1115;0.0255)|Colorectal(1115;0.069)		BRCA - Breast invasive adenocarcinoma(366;0.124)		ACCTCCGCTTGCCCAGCGTGA	0.726		NaN											0	0	0	1	0	6	4				
DBF4B	80174	broad.mit.edu	37	17	42828010	42828010	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:42828010G>C	uc002ihf.2	+	14	1450	c.1237G>C	c.(1237-1239)GAT>CAT	p.D413H	DBF4B_uc010wjc.1_Missense_Mutation_p.D397H	NM_145663	NP_663696	Q8NFT6	DBF4B_HUMAN	DBF4 homolog B isoform 1	413					cell cycle	nucleus	nucleic acid binding|zinc ion binding				0		Prostate(33;0.0322)				AGAATCACTAGATGGTGTGAT	0.607		NaN											0	0	0	1	0	13	40				
KIAA1267	284058	broad.mit.edu	37	17	44159875	44159875	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:44159875C>G	uc002ikb.2	-	3	1550	c.1465G>C	c.(1465-1467)GAG>CAG	p.E489Q	KIAA1267_uc002ikc.2_Missense_Mutation_p.E489Q|KIAA1267_uc002ikd.2_Missense_Mutation_p.E489Q|KIAA1267_uc010dav.2_Missense_Mutation_p.E489Q	NM_015443	NP_056258	Q7Z3B3	K1267_HUMAN	hypothetical protein LOC284058	489						MLL1 complex	protein binding			skin(2)	2		Melanoma(429;0.211)				GTTGTATGCTCTGGGGGAGGT	0.398		NaN											0	0	0	1	0	28	27				
COPZ2	51226	broad.mit.edu	37	17	46111232	46111232	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:46111232C>T	uc002imy.2	-	7	278	c.265G>A	c.(265-267)GAG>AAG	p.E89K		NM_016429	NP_057513	Q9P299	COPZ2_HUMAN	coatomer protein complex, subunit zeta 2	89					intracellular protein transport|vesicle-mediated transport	cis-Golgi network|COPI vesicle coat					0						CACTTACTCTCAGTCCGGCTG	0.483		NaN											0	0	0	1	0	7	5				
XYLT2	64132	broad.mit.edu	37	17	48431301	48431301	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:48431301G>T	uc002iqo.2	+	2	555	c.446G>T	c.(445-447)GGC>GTC	p.G149V	XYLT2_uc010dbo.2_RNA	NM_022167	NP_071450	Q9H1B5	XYLT2_HUMAN	xylosyltransferase II	149	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			pancreas(1)	1	Breast(11;7.18e-19)					AGCGTGGAGGGCGCCCCCCAG	0.687		NaN											1	0	4.68919e-08	1	4.947e-08	9	28				
EPN3	55040	broad.mit.edu	37	17	48616645	48616645	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:48616645G>C	uc002ira.3	+	5	1295	c.860G>C	c.(859-861)AGA>ACA	p.R287T	EPN3_uc010wms.1_Missense_Mutation_p.R315T|EPN3_uc010wmt.1_RNA|EPN3_uc010wmu.1_Missense_Mutation_p.R260T	NM_017957	NP_060427	Q9H201	EPN3_HUMAN	epsin 3	287						clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			ovary(1)	1	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)			AGAGAAGAGAGAAAGGAGGAG	0.542		NaN											0	0	0	1	0	10	36				
TEX14	56155	broad.mit.edu	37	17	56693643	56693643	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:56693643C>G	uc010dcz.1	-	7	796	c.678G>C	c.(676-678)CAG>CAC	p.Q226H	TEX14_uc002iwr.1_Missense_Mutation_p.Q220H|TEX14_uc002iws.1_Missense_Mutation_p.Q220H|TEX14_uc010dda.1_5'UTR	NM_198393	NP_938207	Q8IWB6	TEX14_HUMAN	testis expressed sequence 14 isoform a	226						cytoplasm	ATP binding|protein kinase activity			stomach(4)|lung(3)|breast(3)|ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)|pancreas(1)	17	Medulloblastoma(34;0.127)|all_neural(34;0.237)					GATAGGCCATCTGTGTCGCCC	0.478		NaN											0	0	0	1	0	10	66				
CLTC	1213	broad.mit.edu	37	17	57743482	57743482	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:57743482G>A	uc002ixq.1	+	11	2106	c.1663G>A	c.(1663-1665)GAA>AAA	p.E555K	CLTC_uc002ixp.2_Missense_Mutation_p.E555K|CLTC_uc002ixr.1_Missense_Mutation_p.E559K	NM_004859	NP_004850	Q00610	CLH1_HUMAN	clathrin heavy chain 1	555	Heavy chain arm.|Distal segment.				axon guidance|epidermal growth factor receptor signaling pathway|intracellular protein transport|mitosis|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|post-Golgi vesicle-mediated transport|receptor internalization|transferrin transport	clathrin coat of coated pit|clathrin coat of trans-Golgi network vesicle|cytosol|melanosome|spindle	protein binding|structural molecule activity		CLTC/ALK(44)|CLTC/TFE3(2)	haematopoietic_and_lymphoid_tissue(33)|soft_tissue(11)|kidney(2)|ovary(1)|breast(1)	48	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)					TGTCTTTATGGAATACAATCT	0.333		NaN	T	ALK|TFE3	ALCL|renal 								0	0	0	1	0	9	26				
TBX4	9496	broad.mit.edu	37	17	59560332	59560332	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:59560332C>T	uc002izi.2	+	8	1138	c.1093C>T	c.(1093-1095)CAC>TAC	p.H365Y	TBX4_uc010ddo.2_Missense_Mutation_p.H366Y|TBX4_uc010woy.1_Missense_Mutation_p.H366Y	NM_018488	NP_060958	P57082	TBX4_HUMAN	T-box 4	365					leg morphogenesis|skeletal system morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						GGGGGAGGATCACTATTTCCG	0.552		NaN											0	0	0	1	0	9	26				
TANC2	26115	broad.mit.edu	37	17	61488930	61488930	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:61488930G>A	uc002jal.3	+	20	3449	c.3426G>A	c.(3424-3426)TTG>TTA	p.L1142L	TANC2_uc010wpe.1_Silent_p.L1052L|TANC2_uc002jao.3_Silent_p.L243L	NM_025185	NP_079461	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and	1142	ANK 9.						binding			ovary(2)	2						GGGCTTGTTTGAAGGGCCATC	0.527		NaN											0	0	0	1	0	23	66				
ABCA9	10350	broad.mit.edu	37	17	67023212	67023212	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:67023212G>C	uc002jhu.2	-	15	2098	c.1955C>G	c.(1954-1956)TCA>TGA	p.S652*	ABCA9_uc010dez.2_Nonsense_Mutation_p.S652*	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	652	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					TCGGTGCCTTGAAAGAGGATC	0.438		NaN											0	0	0	1	0	24	46				
C17orf80	55028	broad.mit.edu	37	17	71231891	71231891	+	Silent	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:71231891G>T	uc002jjm.3	+	3	464	c.270G>T	c.(268-270)GTG>GTT	p.V90V	C17orf80_uc010wqu.1_Silent_p.V90V|C17orf80_uc010dfj.2_Silent_p.V90V|C17orf80_uc002jjk.1_Silent_p.V90V|C17orf80_uc002jjl.3_Silent_p.V90V	NM_017941	NP_060411	Q9BSJ5	CQ080_HUMAN	lung cancer-related protein 8 isoform a	90	Extracellular (Potential).					integral to membrane				skin(1)	1			LUSC - Lung squamous cell carcinoma(166;0.197)			AACAGACAGTGAAGACCTTTC	0.388		NaN											1	0	5.03518e-11	1	5.42456e-11	19	36				
KIF19	124602	broad.mit.edu	37	17	72350300	72350300	+	Splice_Site	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:72350300G>C	uc002jkm.3	+	18	2447	c.2309_splice	c.e18-1	p.E770_splice		NM_153209	NP_694941	Q2TAC6	KIF19_HUMAN	kinesin family member 19						microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity				0						TCCCGCTGCAGAGAGGAAGGA	0.587		NaN											0	0	0	1	0	21	76				
GPR142	350383	broad.mit.edu	37	17	72366737	72366737	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:72366737G>C	uc010wqy.1	+	3	436	c.436G>C	c.(436-438)GAG>CAG	p.E146Q	GPR142_uc010wqx.1_Missense_Mutation_p.E58Q	NM_181790	NP_861455	Q7Z601	GP142_HUMAN	G protein-coupled receptor 142	146	Extracellular (Potential).					cell junction|cytoplasm|integral to membrane	G-protein coupled receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4						CCACTGGCCAGAGATCGCAGA	0.647		NaN											0	0	0	1	0	15	33				
KIAA0195	9772	broad.mit.edu	37	17	73491026	73491026	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:73491026C>G	uc002jnz.3	+	20	2914	c.2639C>G	c.(2638-2640)TCC>TGC	p.S880C	KIAA0195_uc010wsa.1_Missense_Mutation_p.S890C|KIAA0195_uc010wsb.1_Missense_Mutation_p.S520C|KIAA0195_uc002job.3_5'Flank	NM_014738	NP_055553	Q12767	K0195_HUMAN	hypothetical protein LOC9772	880					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			ovary(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			TGCCACATCTCCCTCACACCC	0.582		NaN											0	0	0	1	0	36	80				
H3F3B	3021	broad.mit.edu	37	17	73775024	73775024	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:73775024C>G	uc002jpl.2	-	3	282	c.149G>C	c.(148-150)CGA>CCA	p.R50P		NM_005324	NP_005315	P84243	H33_HUMAN	H3 histone, family 3B	50					blood coagulation|nucleosome assembly	nucleoplasm|nucleosome	DNA binding			ovary(1)	1	all_cancers(13;1.5e-07)		all cancers(21;2.61e-06)|Epithelial(20;7.39e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|LUSC - Lung squamous cell carcinoma(166;0.154)			ACGAATCTCTCGAAGCGCCAC	0.652		NaN									OREG0024740	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	11	35				
UNC13D	201294	broad.mit.edu	37	17	73830498	73830498	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:73830498G>A	uc002jpp.2	-	23	2586	c.2206C>T	c.(2206-2208)CAG>TAG	p.Q736*	UNC13D_uc010wsk.1_Nonsense_Mutation_p.Q736*|UNC13D_uc002jpq.1_Nonsense_Mutation_p.Q386*	NM_199242	NP_954712	Q70J99	UN13D_HUMAN	unc-13 homolog D	736					positive regulation of exocytosis|regulation of mast cell degranulation	exocytic vesicle|late endosome|lysosome|membrane|recycling endosome	protein binding			upper_aerodigestive_tract(1)|skin(1)	2			all cancers(21;2.11e-06)|Epithelial(20;2.32e-06)|BRCA - Breast invasive adenocarcinoma(9;0.000618)|LUSC - Lung squamous cell carcinoma(166;0.154)			TTCTGCAGCTGCCCCTGCTCC	0.692		NaN							Familial_Hemophagocytic_Lymphohistiocytosis				0	0	0	1	0	10	3				
QRICH2	84074	broad.mit.edu	37	17	74274098	74274098	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:74274098G>C	uc002jrd.1	-	15	4771	c.4591C>G	c.(4591-4593)CAG>GAG	p.Q1531E	QRICH2_uc010wsz.1_Intron|QRICH2_uc010dgw.1_Missense_Mutation_p.Q375E	NM_032134	NP_115510	Q9H0J4	QRIC2_HUMAN	glutamine rich 2	1531							protein binding			ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)|skin(1)	5						CCCAGGCACTGGGCGTGCAGC	0.627		NaN											0	0	0	1	0	24	71				
EIF4A3	9775	broad.mit.edu	37	17	78111251	78111251	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:78111251G>C	uc010wuc.1	-	10	990	c.917C>G	c.(916-918)TCA>TGA	p.S306*	EIF4A3_uc002jxs.2_Nonsense_Mutation_p.S306*	NM_014740	NP_055555	P38919	IF4A3_HUMAN	eukaryotic translation initiation factor 4A,	306	Helicase C-terminal.				mRNA transport|negative regulation of translation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation|rRNA processing	catalytic step 2 spliceosome|cytoplasm|exon-exon junction complex|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|poly(A) RNA binding|protein binding			ovary(1)	1	all_neural(118;0.117)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.139)			TCCATGCATTGAGGATACAGT	0.532		NaN											0	0	0	1	0	12	15				
PYCR1	5831	broad.mit.edu	37	17	79893381	79893381	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:79893381C>T	uc002kcr.1	-	3	428	c.150G>A	c.(148-150)GTG>GTA	p.V50V	PYCR1_uc002kcq.1_Silent_p.V50V|PYCR1_uc002kcp.2_Silent_p.V50V|PYCR1_uc002kcs.1_Silent_p.V50V|PYCR1_uc010wvd.1_Silent_p.V77V|PYCR1_uc002kct.1_Silent_p.V50V|PYCR1_uc002kcu.1_Silent_p.V50V|PYCR1_uc010wve.1_Silent_p.V3V	NM_006907	NP_008838	P32322	P5CR1_HUMAN	pyrroline-5-carboxylate reductase 1 isoform 1	50					cellular response to oxidative stress|proline biosynthetic process	mitochondrial matrix	binding|pyrroline-5-carboxylate reductase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0165)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)		L-Proline(DB00172)|NADH(DB00157)	GTGTCAACTTCACCCCCATCT	0.582		NaN											0	0	0	1	0	6	16				
CLUL1	27098	broad.mit.edu	37	18	641518	641518	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr18:641518G>C	uc002kkp.2	+	7	1331	c.1186G>C	c.(1186-1188)GAG>CAG	p.E396Q	CLUL1_uc010wys.1_Missense_Mutation_p.E448Q|CLUL1_uc002kkq.2_Missense_Mutation_p.E396Q	NM_014410	NP_055225	Q15846	CLUL1_HUMAN	clusterin-like 1 (retinal) precursor	396					cell death	extracellular region				ovary(2)	2						CCCAGAAACAGAGATCATCTT	0.458		NaN											0	0	0	1	0	20	29				
MYOM1	8736	broad.mit.edu	37	18	3129355	3129355	+	Missense_Mutation	SNP	T	T	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr18:3129355T>A	uc002klp.2	-	18	3003	c.2669A>T	c.(2668-2670)AAC>ATC	p.N890I	MYOM1_uc002klq.2_Intron	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	890						striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						TTGGCCCAGGTTTTGAGAGCT	0.522		NaN									OREG0024838	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	39	122				
RAB12	201475	broad.mit.edu	37	18	8624969	8624969	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr18:8624969G>C	uc002knp.2	+	2	543	c.260G>C	c.(259-261)AGA>ACA	p.R87T		NM_001025300	NP_001020471	Q6IQ22	RAB12_HUMAN	RAB12, member RAS oncogene family	87					protein transport|small GTPase mediated signal transduction	Golgi membrane	GTP binding				0						GTAGAGCTAAGAGGAAAGAAA	0.333		NaN											0	0	0	1	0	31	130				
KIAA0802	23255	broad.mit.edu	37	18	8793020	8793020	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr18:8793020G>C	uc002knr.2	+	8	2054	c.1912G>C	c.(1912-1914)GAG>CAG	p.E638Q	KIAA0802_uc002knq.2_Intron|KIAA0802_uc002kns.2_Intron	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0						CGTTTTACCTGAGCAGAGTGT	0.527		NaN											0	0	0	1	0	40	130				
SEH1L	81929	broad.mit.edu	37	18	12948141	12948141	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr18:12948141C>T	uc002krr.2	+	1	159	c.21C>T	c.(19-21)ATC>ATT	p.I7I	SEH1L_uc002krq.2_Silent_p.I7I	NM_031216	NP_112493	Q96EE3	SEH1_HUMAN	sec13-like protein isoform 2	7					attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|carbohydrate metabolic process|cell division|glucose transport|mitotic metaphase plate congression|mitotic prometaphase|mRNA transport|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex					0						CTCGCAGCATCGCGGCGGACC	0.672		NaN											0	0	0	1	0	7	14				
IMPACT	55364	broad.mit.edu	37	18	22008854	22008854	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr18:22008854C>G	uc002kvh.3	+	3	299	c.187C>G	c.(187-189)CCA>GCA	p.P63A	IMPACT_uc002kvg.3_Missense_Mutation_p.P45A	NM_018439	NP_060909	Q9P2X3	IMPCT_HUMAN	Impact homolog	63	RWD.										0	all_cancers(21;0.00018)|all_epithelial(16;1.5e-06)|Lung NSC(20;0.0027)|all_lung(20;0.0085)|Colorectal(14;0.0361)|Ovarian(20;0.0991)					GAATGAATACCCAGGTACAGC	0.353		NaN											0	0	0	1	0	12	48				
MYO5B	4645	broad.mit.edu	37	18	47404156	47404156	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr18:47404156C>T	uc002leb.2	-	25	3661	c.3373G>A	c.(3373-3375)GAG>AAG	p.E1125K	MYO5B_uc002lea.2_Missense_Mutation_p.E266K	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	1125	Potential.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		AGGGCATCCTCAGTGTCTCCG	0.512		NaN											0	0	0	1	0	53	28				
SERPINB2	5055	broad.mit.edu	37	18	61570328	61570328	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr18:61570328G>A	uc010xeu.1	+	9	1370	c.1037G>A	c.(1036-1038)AGG>AAG	p.R346K	SERPINB2_uc002ljo.2_Missense_Mutation_p.R346K|SERPINB2_uc010dqh.2_Missense_Mutation_p.R276K|SERPINB2_uc002ljp.1_Intron|SERPINB2_uc002ljq.1_Intron	NM_001143818	NP_001137290	P05120	PAI2_HUMAN	serine (or cysteine) proteinase inhibitor, clade	346					anti-apoptosis|blood coagulation|fibrinolysis|regulation of proteolysis	extracellular space|Golgi apparatus|plasma membrane	serine-type endopeptidase inhibitor activity			lung(1)|skin(1)	2		Esophageal squamous(42;0.131)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)|Urokinase(DB00013)	ATGTCGGAGAGGAATGACCTG	0.507		NaN											0	0	0	1	0	8	28				
CDH7	1005	broad.mit.edu	37	18	63526160	63526160	+	Splice_Site	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr18:63526160G>C	uc002ljz.2	+	9	1698	c.1373_splice	c.e9-1	p.Q458_splice	CDH7_uc002lka.2_Splice_Site_p.Q458_splice|CDH7_uc002lkb.2_Splice_Site_p.Q458_splice	NM_033646	NP_387450	Q9ULB5	CADH7_HUMAN	cadherin 7, type 2 preproprotein						adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|pancreas(1)|skin(1)	4		Esophageal squamous(42;0.129)				TTATTTATTAGAGAATCCATC	0.373		NaN											0	0	0	1	0	13	20				
NETO1	81832	broad.mit.edu	37	18	70532056	70532056	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr18:70532056G>C	uc002lkw.2	-	3	491	c.207C>G	c.(205-207)ATC>ATG	p.I69M	NETO1_uc002lkx.1_Missense_Mutation_p.I68M|NETO1_uc002lky.1_Missense_Mutation_p.I69M|NETO1_uc002lkz.2_Missense_Mutation_p.I68M	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	69	CUB 1.|Extracellular (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		CTATGATGTAGATGCATTCCC	0.473		NaN											0	0	0	1	0	17	36				
CNDP1	84735	broad.mit.edu	37	18	72226648	72226648	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr18:72226648G>T	uc002llq.2	+	3	455	c.244G>T	c.(244-246)GCG>TCG	p.A82S	uc002llr.2_RNA	NM_032649	NP_116038	Q96KN2	CNDP1_HUMAN	carnosinase 1 precursor	82					proteolysis	extracellular region	carboxypeptidase activity|dipeptidase activity|metal ion binding|metallopeptidase activity|tripeptidase activity				0		Esophageal squamous(42;0.129)|Prostate(75;0.157)|Melanoma(33;0.211)		BRCA - Breast invasive adenocarcinoma(31;0.109)		GGCCGTGGCTGCGGACACGCT	0.622		NaN											1	0	0.000602214	1	0.000612452	5	51				
ZNF407	55628	broad.mit.edu	37	18	72345042	72345042	+	Silent	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr18:72345042C>A	uc002llw.2	+	1	2124	c.2067C>A	c.(2065-2067)TCC>TCA	p.S689S	ZNF407_uc010xfc.1_Silent_p.S689S|ZNF407_uc010dqu.1_Silent_p.S689S|ZNF407_uc002llu.2_Silent_p.S688S	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	689					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		CTCTGAAGTCCAGGGTAAGCC	0.398		NaN											1	0	6.40141e-05	1	6.58264e-05	11	33				
PTBP1	5725	broad.mit.edu	37	19	804643	804643	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:804643G>A	uc002lpr.2	+	6	653	c.547G>A	c.(547-549)GTG>ATG	p.V183M	PTBP1_uc002lpp.2_Missense_Mutation_p.V183M|PTBP1_uc002lpq.2_Missense_Mutation_p.V183M|PTBP1_uc002lps.2_Intron|PTBP1_uc002lpt.2_RNA|PTBP1_uc002lpu.1_Missense_Mutation_p.V153M	NM_031991	NP_114368	P26599	PTBP1_HUMAN	polypyrimidine tract-binding protein 1 isoform	183					negative regulation of muscle cell differentiation|nuclear mRNA splicing, via spliceosome|regulation of alternative nuclear mRNA splicing, via spliceosome	heterogeneous nuclear ribonucleoprotein complex|nucleolus|nucleoplasm	mRNA binding|nucleotide binding|poly-pyrimidine tract binding|protein binding			kidney(1)|skin(1)	2		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;6.59e-06)|all_lung(49;9.97e-06)|Breast(49;0.000172)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCAGAGCCCCGTGCTCAGGAT	0.677		NaN											0	0	0	1	0	18	25				
KLF16	83855	broad.mit.edu	37	19	1863162	1863162	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:1863162G>C	uc002luc.2	-	1	403	c.335C>G	c.(334-336)TCG>TGG	p.S112W	KLF16_uc010xgt.1_RNA	NM_031918	NP_114124	Q9BXK1	KLF16_HUMAN	BTE-binding protein 4	112	Ser-rich.|Ala/Pro-rich.					nucleus	DNA binding|zinc ion binding				0		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ggcgcggcccgaggacgggga	0.448		NaN											0	0	0	1	0	2	0				
DOT1L	84444	broad.mit.edu	37	19	2217074	2217074	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:2217074G>C	uc002lvb.3	+	21	2565	c.2529G>C	c.(2527-2529)GAG>GAC	p.E843D	DOT1L_uc002lvc.1_Missense_Mutation_p.E137D|uc002lvd.1_5'Flank|DOT1L_uc002lve.1_Missense_Mutation_p.E137D	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	843						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TTGCTGGAGAGAAGAGCAGTG	0.687		NaN											0	0	0	1	0	6	16		Valid		
DPP9	91039	broad.mit.edu	37	19	4689638	4689638	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:4689638C>T	uc002mba.2	-	15	1951	c.1693G>A	c.(1693-1695)GGC>AGC	p.G565S		NM_139159	NP_631898	Q86TI2	DPP9_HUMAN	dipeptidylpeptidase 9	536					proteolysis	cytosol|membrane	aminopeptidase activity|serine-type peptidase activity			skin(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00884)		ACGATCTCGCCGGCCGCCTCA	0.652		NaN											0	0	0	1	0	2	2				
RANBP3	8498	broad.mit.edu	37	19	5927994	5927994	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:5927994C>G	uc002mdw.2	-	9	1025	c.798G>C	c.(796-798)TTG>TTC	p.L266F	RANBP3_uc002mdv.2_5'UTR|RANBP3_uc002mdx.2_Missense_Mutation_p.L261F|RANBP3_uc002mdy.2_Missense_Mutation_p.L198F|RANBP3_uc002mdz.2_Missense_Mutation_p.L193F|RANBP3_uc010duq.2_Missense_Mutation_p.L171F|RANBP3_uc002mea.2_Missense_Mutation_p.L133F|RANBP3_uc010xix.1_Missense_Mutation_p.L138F	NM_007322	NP_015561	Q9H6Z4	RANB3_HUMAN	RAN binding protein 3 isoform RANBP3-d	266					intracellular transport|protein transport	cytoplasm|nucleus	Ran GTPase binding			breast(1)	1						CTCTGTCCCTCAAGTTCTGCC	0.463		NaN											0	0	0	1	0	74	55				
TUBB4	10382	broad.mit.edu	37	19	6495749	6495749	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:6495749G>C	uc002mfg.1	-	4	868	c.761C>G	c.(760-762)GCC>GGC	p.A254G	TUBB4_uc002mff.1_Missense_Mutation_p.A182G|MIR220B_hsa-mir-220b|MI0005529_5'Flank	NM_006087	NP_006078	P04350	TBB4_HUMAN	tubulin, beta 4	254					'de novo' posttranslational protein folding|G2/M transition of mitotic cell cycle|microtubule-based movement|protein polymerization	cytosol|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(2)	2		Hepatocellular(1079;0.00213)|Renal(1328;0.0183)		Lung(535;3.23e-05)|STAD - Stomach adenocarcinoma(1328;8.24e-05)|GBM - Glioblastoma multiforme(1328;0.00839)|READ - Rectum adenocarcinoma(264;0.155)		CATGTTGACGGCCAGCTTGCG	0.682		NaN											0	0	0	1	0	18	110				
TNFSF14	8740	broad.mit.edu	37	19	6665079	6665079	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:6665079G>A	uc002mfk.1	-	5	963	c.581C>T	c.(580-582)TCC>TTC	p.S194F	TNFSF14_uc002mfj.1_Missense_Mutation_p.S158F	NM_003807	NP_003798	O43557	TNF14_HUMAN	tumor necrosis factor ligand superfamily, member	194	Extracellular (Potential).				cellular response to mechanical stimulus|immune response|induction of apoptosis|release of cytoplasmic sequestered NF-kappaB|T cell homeostasis|T cell proliferation	cytoplasm|extracellular space|integral to membrane|plasma membrane	caspase inhibitor activity|cytokine activity|tumor necrosis factor receptor binding			skin(1)	1						CCAGACCCGGGAGCTGCTGGT	0.657		NaN											0	0	0	1	0	26	56				
PNPLA6	10908	broad.mit.edu	37	19	7615490	7615490	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:7615490G>A	uc010xjq.1	+	18	2256	c.2061G>A	c.(2059-2061)CTG>CTA	p.L687L	PNPLA6_uc002mgq.1_Silent_p.L639L|PNPLA6_uc010xjp.1_Silent_p.L613L|PNPLA6_uc002mgr.1_Silent_p.L639L|PNPLA6_uc002mgs.2_Silent_p.L678L	NM_006702	NP_006693	Q8IY17	PLPL6_HUMAN	neuropathy target esterase isoform b	678	Cytoplasmic (Potential).|cNMP 3.				cell death|lipid catabolic process|phosphatidylcholine metabolic process	endoplasmic reticulum membrane|integral to membrane	lysophospholipase activity			ovary(3)	3						AGAAGGAGCTGGTGGGCGAGT	0.662		NaN											0	0	0	1	0	17	22				
OR2Z1	284383	broad.mit.edu	37	19	8841489	8841489	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:8841489C>T	uc010xkg.1	+	1	99	c.99C>T	c.(97-99)GTC>GTT	p.V33V		NM_001004699	NP_001004699	Q8NG97	OR2Z1_HUMAN	olfactory receptor, family 2, subfamily Z,	33	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2						TGGTGGCTGTCATGTTTGTCA	0.552		NaN											0	0	0	1	0	36	66				
MUC16	94025	broad.mit.edu	37	19	8969428	8969428	+	Splice_Site	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:8969428C>G	uc002mkp.2	-	79	43121	c.42917_splice	c.e79-1	p.E14306_splice	MUC16_uc010dwi.2_Splice_Site|MUC16_uc010dwj.2_Splice_Site_p.E1106_splice|MUC16_uc010xki.1_Splice_Site	NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16						cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GACTCCATTTCTAGAATTAAA	0.403		NaN											0	0	0	1	0	24	16				
MUC16	94025	broad.mit.edu	37	19	9083460	9083460	+	Silent	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:9083460C>G	uc002mkp.2	-	1	8559	c.8355G>C	c.(8353-8355)GTG>GTC	p.V2785V		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2785	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTAGTGGCATCACAGATGCCC	0.502		NaN											0	0	0	1	0	8	40				
TYK2	7297	broad.mit.edu	37	19	10476364	10476364	+	Silent	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:10476364C>G	uc002moc.3	-	7	1218	c.840G>C	c.(838-840)CTG>CTC	p.L280L	TYK2_uc010dxe.2_Silent_p.L95L|TYK2_uc002mod.2_Silent_p.L280L	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	280	FERM.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			CCAGCAGCCTCAGGTGGCACA	0.687		NaN											0	0	0	1	0	16	30				
TYK2	7297	broad.mit.edu	37	19	10478979	10478979	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:10478979G>A	uc002moc.3	-	4	687	c.309C>T	c.(307-309)TTC>TTT	p.F103F	TYK2_uc010dxe.2_Intron|TYK2_uc002mod.2_Silent_p.F103F	NM_003331	NP_003322	P29597	TYK2_HUMAN	tyrosine kinase 2	103	FERM.				intracellular protein kinase cascade|regulation of type I interferon-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoskeleton|cytosol|membrane|nucleus	ATP binding|growth hormone receptor binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|large_intestine(2)|ovary(1)|breast(1)	9			OV - Ovarian serous cystadenocarcinoma(20;1.77e-09)|Epithelial(33;3.92e-06)|all cancers(31;8.95e-06)			ACCTTATGCGGAAATATAGCA	0.557		NaN											0	0	0	1	0	76	92				
DNM2	1785	broad.mit.edu	37	19	10930726	10930726	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:10930726C>T	uc002mps.1	+	16	1906	c.1742C>T	c.(1741-1743)TCC>TTC	p.S581F	DNM2_uc010dxk.2_Intron|DNM2_uc002mpt.1_Missense_Mutation_p.S581F|DNM2_uc002mpv.1_Missense_Mutation_p.S577F|DNM2_uc002mpu.1_Missense_Mutation_p.S577F|DNM2_uc010dxl.1_Missense_Mutation_p.S581F|DNM2_uc002mpw.2_Missense_Mutation_p.S310F|uc010xlj.1_5'Flank|MIR199A1_hsa-mir-199a-1|MI0000242_5'Flank	NM_001005361	NP_001005361	P50570	DYN2_HUMAN	dynamin 2 isoform 2	581	PH.				G2/M transition of mitotic cell cycle|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|post-Golgi vesicle-mediated transport|receptor internalization|signal transduction|synaptic vesicle transport|transferrin transport	cell junction|cytosol|Golgi membrane|microtubule|postsynaptic density|postsynaptic membrane	GTP binding|GTPase activity|microtubule binding			central_nervous_system(2)|skin(2)|ovary(1)|breast(1)	6			Epithelial(33;4.17e-05)|all cancers(31;8.48e-05)			GGCTTCATGTCCAACAAGCAC	0.562		NaN											0	0	0	1	0	32	103				
SMARCA4	6597	broad.mit.edu	37	19	11138491	11138491	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:11138491G>A	uc002mqf.3	+	24	3531	c.3247G>A	c.(3247-3249)GAG>AAG	p.E1083K	SMARCA4_uc010dxp.2_Missense_Mutation_p.E1083K|SMARCA4_uc010dxo.2_Missense_Mutation_p.E1083K|SMARCA4_uc002mqg.1_Missense_Mutation_p.E1083K|SMARCA4_uc010dxq.2_Missense_Mutation_p.E1083K|SMARCA4_uc010dxr.2_Missense_Mutation_p.E1083K|SMARCA4_uc002mqj.3_Missense_Mutation_p.E1083K|SMARCA4_uc010dxs.2_Missense_Mutation_p.E1083K|SMARCA4_uc010dxt.1_Missense_Mutation_p.E303K|SMARCA4_uc002mqh.3_Missense_Mutation_p.E206K|SMARCA4_uc002mqi.1_Missense_Mutation_p.E286K	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1083					chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(2)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				GGGTAAATTTGAGCTTCTTGA	0.517		NaN	F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				0	0	0	1	0	64	66		Valid		
ZNF491	126069	broad.mit.edu	37	19	11917579	11917579	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:11917579C>G	uc002mso.1	+	3	1096	c.811C>G	c.(811-813)CAT>GAT	p.H271D		NM_152356	NP_689569	Q8N8L2	ZN491_HUMAN	zinc finger protein 491	271	C2H2-type 8.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						AGAGAGGCCTCATAAATGTAA	0.408		NaN											0	0	0	1	0	39	54				
ZNF878	729747	broad.mit.edu	37	19	12155622	12155622	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:12155622G>A	uc002mta.1	-	5	735	c.735C>T	c.(733-735)CCC>CCT	p.P245P		NM_001080404	NP_001073873	C9JN71	ZN878_HUMAN	zinc finger protein 878	198					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						TACATTCATAGGGTTTTTTTG	0.388		NaN											0	0	0	1	0	114	121				
ZNF878	729747	broad.mit.edu	37	19	12156003	12156003	+	Silent	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:12156003G>C	uc002mta.1	-	5	354	c.354C>G	c.(352-354)CTC>CTG	p.L118L		NM_001080404	NP_001073873	C9JN71	ZN878_HUMAN	zinc finger protein 878	71	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						TACTTTCAGAGAGTCTCTCCC	0.353		NaN											0	0	0	1	0	10	16				
ZNF878	729747	broad.mit.edu	37	19	12157504	12157504	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:12157504C>A	uc002mta.1	-	3	216	c.216G>T	c.(214-216)CAG>CAT	p.Q72H		NM_001080404	NP_001073873	C9JN71	ZN878_HUMAN	zinc finger protein 878	25	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						AGAGATTTTTCTGGGAAGGAT	0.478		NaN											1	0	2.02627e-32	1	2.28715e-32	67	88				
CC2D1A	54862	broad.mit.edu	37	19	14040949	14040949	+	Silent	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:14040949G>C	uc002mxo.2	+	27	3068	c.2769G>C	c.(2767-2769)CTG>CTC	p.L923L	CC2D1A_uc002mxp.2_Silent_p.L922L|CC2D1A_uc010dzh.2_Silent_p.L492L	NM_017721	NP_060191	Q6P1N0	C2D1A_HUMAN	coiled-coil and C2 domain containing 1A	923					positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus|plasma membrane	DNA binding|signal transducer activity				0			OV - Ovarian serous cystadenocarcinoma(19;3.49e-23)			CCCGGCGCCTGGGCAACGATG	0.692		NaN											0	0	0	1	0	10	46				
CYP4F8	11283	broad.mit.edu	37	19	15728816	15728816	+	Silent	SNP	T	T	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:15728816T>G	uc002nbi.2	+	3	268	c.204T>G	c.(202-204)ACT>ACG	p.T68T	CYP4F8_uc010xoi.1_Silent_p.T68T|CYP4F8_uc010xoj.1_Intron	NM_007253	NP_009184	P98187	CP4F8_HUMAN	cytochrome P450, family 4, subfamily F,	68					prostaglandin metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	alkane 1-monooxygenase activity|aromatase activity|electron carrier activity|heme binding|oxygen binding|protein binding			large_intestine(1)	1						TGCAGGTCACTCCCACAGAGG	0.413		NaN											0	0	0	1	0	11	47				
USE1	55850	broad.mit.edu	37	19	17327021	17327021	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:17327021C>G	uc002nfo.2	+	4	335	c.275C>G	c.(274-276)CCT>CGT	p.P92R	USE1_uc002nfn.2_Missense_Mutation_p.P92R|USE1_uc010eal.1_Missense_Mutation_p.P92R	NM_018467	NP_060937	Q9NZ43	USE1_HUMAN	unconventional SNARE in the ER 1 homolog	92	Cytoplasmic (Potential).				lysosomal transport|protein catabolic process|protein transport|secretion by cell|vesicle-mediated transport	endoplasmic reticulum membrane|integral to membrane	protein binding				0						TTCCTGGCCCCTGGCCGTGTG	0.607		NaN											0	0	0	1	0	10	45				
GTPBP3	84705	broad.mit.edu	37	19	17452366	17452366	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:17452366C>G	uc010eas.2	+	9	1398	c.1333C>G	c.(1333-1335)CTC>GTC	p.L445V	GTPBP3_uc010xpo.1_Missense_Mutation_p.L467V|GTPBP3_uc002ngh.3_Missense_Mutation_p.L424V|GTPBP3_uc002ngg.3_Missense_Mutation_p.L477V|GTPBP3_uc002ngi.3_Missense_Mutation_p.L111V	NM_032620	NP_116009	Q969Y2	GTPB3_HUMAN	GTP binding protein 3 (mitochondrial) isoform V	445					tRNA modification	mitochondrion	GTP binding|GTPase activity			skin(1)	1						CCTGGATGCCCTCGGCCACTA	0.657		NaN											0	0	0	1	0	20	55				
NXNL1	115861	broad.mit.edu	37	19	17571379	17571379	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:17571379G>T	uc002ngs.2	-	1	347	c.300C>A	c.(298-300)TTC>TTA	p.F100L		NM_138454	NP_612463	Q96CM4	NXNL1_HUMAN	nucleoredoxin-like 1	100	Thioredoxin.				cell redox homeostasis	nuclear outer membrane					0						CAAAGGGCAGGAAAAGCCATT	0.378		NaN											1	0	6.38683e-12	1	6.92474e-12	26	28				
MPV17L2	84769	broad.mit.edu	37	19	18304802	18304802	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:18304802C>T	uc002nid.2	+	2	368	c.316C>T	c.(316-318)CAG>TAG	p.Q106*	MPV17L2_uc010ebj.2_Nonsense_Mutation_p.Q42*	NM_032683	NP_116072	Q567V2	M17L2_HUMAN	MPV17 mitochondrial membrane protein-like 2	106	Helical; (Potential).					integral to membrane					0						CCTCGTGGATCAGCTGGTAGC	0.592		NaN											0	0	0	1	0	13	34				
SLC25A42	284439	broad.mit.edu	37	19	19218757	19218757	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:19218757G>A	uc002nlf.1	+	7	703	c.552G>A	c.(550-552)AAG>AAA	p.K184K		NM_178526	NP_848621	Q86VD7	S2542_HUMAN	solute carrier family 25, member 42	184	Solcar 2.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0			OV - Ovarian serous cystadenocarcinoma(5;5.4e-06)|Epithelial(12;0.000497)			AGGGGCTGAAGACTCTCTACC	0.562		NaN											0	0	0	1	0	84	66				
ZNF99	7652	broad.mit.edu	37	19	22939880	22939880	+	Silent	SNP	A	A	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:22939880A>T	uc010xrh.1	-	6	2451	c.2451T>A	c.(2449-2451)CTT>CTA	p.L817L		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				TATGTTTCTTAAGGGTTGAGG	0.383		NaN											0	0	0	1	0	16	102				
C19orf40	91442	broad.mit.edu	37	19	33467501	33467501	+	Silent	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:33467501G>C	uc002nud.3	+	5	679	c.561G>C	c.(559-561)CTG>CTC	p.L187L		NM_152266	NP_689479	Q9BTP7	FAP24_HUMAN	Fanconi anemia-associated protein, 24 kDa	187	RuvA domain 2-like.				DNA repair	Fanconi anaemia nuclear complex	chromatin binding|DNA binding|protein binding				0	Esophageal squamous(110;0.137)					TCCAGCAACTGAGTAATGCTT	0.557		NaN						Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks			OREG0025408	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	30	132				
SCN1B	6324	broad.mit.edu	37	19	35530030	35530030	+	Missense_Mutation	SNP	A	A	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:35530030A>T	uc002nxp.2	+	4	649	c.458A>T	c.(457-459)GAC>GTC	p.D153V	SCN1B_uc010xsg.1_Missense_Mutation_p.D82V|HPN_uc002nxq.1_5'Flank|HPN_uc002nxr.1_5'Flank|HPN_uc002nxs.1_5'Flank	NM_001037	NP_001028	Q07699	SCN1B_HUMAN	sodium channel, voltage-gated, type I, beta	153	Extracellular (Potential).				axon guidance|synaptic transmission	integral to membrane	voltage-gated sodium channel activity			ovary(1)|central_nervous_system(1)	2	all_lung(56;2.66e-08)|Lung NSC(56;4.13e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0849)			GCCAACAGAGACATGGCATCC	0.363		NaN											0	0	0	1	0	97	85				
DMKN	93099	broad.mit.edu	37	19	36002341	36002341	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:36002341C>A	uc002nzm.3	-	5	1073	c.890G>T	c.(889-891)AGA>ATA	p.R297I	DMKN_uc002nzj.2_5'Flank|DMKN_uc002nzk.3_5'Flank|DMKN_uc002nzl.3_5'Flank|DMKN_uc002nzo.3_Intron|DMKN_uc002nzn.3_Intron|DMKN_uc002nzw.2_5'Flank|DMKN_uc002nzr.2_5'Flank|DMKN_uc002nzp.2_5'Flank|DMKN_uc002nzq.2_5'Flank|DMKN_uc002nzt.2_5'Flank|DMKN_uc002nzs.2_5'Flank|DMKN_uc002nzu.2_5'Flank|DMKN_uc002nzv.2_5'Flank|DMKN_uc010xsv.1_5'Flank|DMKN_uc010xsw.1_5'Flank|DMKN_uc002nzx.3_5'Flank|DMKN_uc002nzy.3_5'Flank|DMKN_uc002nzz.2_RNA|DMKN_uc002oac.3_Missense_Mutation_p.R297I|DMKN_uc010eeb.2_Missense_Mutation_p.R297I|DMKN_uc002oaa.3_Missense_Mutation_p.R297I|DMKN_uc002oab.3_Missense_Mutation_p.R297I	NM_033317	NP_201574	Q6E0U4	DMKN_HUMAN	dermokine isoform 2 precursor	297	Gly-rich.					extracellular region				large_intestine(1)|ovary(1)|skin(1)	3	all_lung(56;1.89e-08)|Lung NSC(56;2.9e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			GCTGTCACCTctgctgccacc	0.318		NaN											1	0	0.004672	1	0.00472309	3	23				
KIRREL2	84063	broad.mit.edu	37	19	36357214	36357214	+	Silent	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:36357214C>A	uc002ocb.3	+	15	2159	c.1947C>A	c.(1945-1947)GTC>GTA	p.V649V	KIRREL2_uc002obz.3_Intron|KIRREL2_uc002oca.3_Intron|KIRREL2_uc002occ.3_Silent_p.V596V|KIRREL2_uc002ocd.3_Silent_p.V611V|APLP1_uc010xsz.1_5'Flank|APLP1_uc002oce.2_5'Flank|APLP1_uc002ocf.2_5'Flank|APLP1_uc002ocg.2_5'Flank	NM_199180	NP_954649	Q6UWL6	KIRR2_HUMAN	kin of IRRE-like 2 isoform c	649	Pro-rich.|Cytoplasmic (Potential).				cell adhesion	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TGGGCATGGTCCCCCCCTGCA	0.627		NaN											1	0	1.37285e-15	1	1.51267e-15	17	106				
WDR62	284403	broad.mit.edu	37	19	36593683	36593683	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:36593683G>A	uc002odc.2	+	27	3341	c.3250G>A	c.(3250-3252)GAA>AAA	p.E1084K	WDR62_uc002odd.2_Missense_Mutation_p.E1089K	NM_173636	NP_775907	O43379	WDR62_HUMAN	WD repeat domain 62 isoform 2	1084					cerebral cortex development	nucleus					0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			CTCTGAAGCTGAAGACCACTT	0.617		NaN											0	0	0	1	0	15	54				
COX7A1	1346	broad.mit.edu	37	19	36642380	36642380	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:36642380C>T	uc002odm.1	-	3	633	c.171G>A	c.(169-171)ATG>ATA	p.M57I		NM_001864	NP_001855	P24310	CX7A1_HUMAN	cytochrome c oxidase subunit VIIa polypeptide 1	57	Helical; (By similarity).				generation of precursor metabolites and energy	integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity|electron carrier activity				0	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.06)			GACACAGCGTCATTGTCACTC	0.617		NaN											0	0	0	1	0	9	77				
MAP4K1	11184	broad.mit.edu	37	19	39103253	39103253	+	Silent	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:39103253G>C	uc002oix.1	-	9	771	c.663C>G	c.(661-663)CTC>CTG	p.L221L	MAP4K1_uc002oiy.1_Silent_p.L221L|MAP4K1_uc010xug.1_5'UTR	NM_007181	NP_009112	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase	221	Protein kinase.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			skin(4)|lung(3)|ovary(1)	8	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			CTGCCTACCTGAGAGGGTGCA	0.607		NaN											0	0	0	1	0	30	26				
ACTN4	81	broad.mit.edu	37	19	39208629	39208629	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:39208629G>A	uc002oja.1	+	11	1265	c.1206G>A	c.(1204-1206)CTG>CTA	p.L402L	ACTN4_uc010egc.1_Silent_p.L402L	NM_004924	NP_004915	O43707	ACTN4_HUMAN	actinin, alpha 4	402	Spectrin 1.				platelet activation|platelet degranulation|positive regulation of cellular component movement|positive regulation of sodium:hydrogen antiporter activity|protein transport|regulation of apoptosis	extracellular region|nucleolus|perinuclear region of cytoplasm|platelet alpha granule lumen|protein complex|pseudopodium|ribonucleoprotein complex	actin filament binding|calcium ion binding|integrin binding|nucleoside binding|protein homodimerization activity				0	all_cancers(60;1.57e-05)|Ovarian(47;0.103)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			AGTGGCTGCTGAATGAGATCC	0.627		NaN											0	0	0	1	0	5	10				
NFKBIB	4793	broad.mit.edu	37	19	39396010	39396010	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:39396010C>T	uc002ojw.2	+	3	512	c.454C>T	c.(454-456)CGG>TGG	p.R152W	NFKBIB_uc002ojx.2_Missense_Mutation_p.R120W|NFKBIB_uc002ojy.2_Missense_Mutation_p.R152W	NM_002503	NP_002494	Q15653	IKBB_HUMAN	nuclear factor of kappa light polypeptide gene	152	ANK 3.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription, DNA-dependent	cytosol|nucleus	protein binding|signal transducer activity|transcription coactivator activity			lung(1)|kidney(1)	2	all_cancers(60;4.39e-06)|Ovarian(47;0.0454)		Lung(45;0.000419)|LUSC - Lung squamous cell carcinoma(53;0.000554)			GCCCCGCCCCCGGCGCCCCAG	0.711		NaN											0	0	0	1	0	44	21				
FCGBP	8857	broad.mit.edu	37	19	40368511	40368511	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:40368511G>A	uc002omp.3	-	28	12845	c.12837C>T	c.(12835-12837)TTC>TTT	p.F4279F		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4279	VWFD 10.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			GGGGTCCGCAGAAGCCAGGGC	0.642		NaN											0	0	0	1	0	9	29				
FCGBP	8857	broad.mit.edu	37	19	40433168	40433168	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:40433168G>A	uc002omp.3	-	2	1109	c.1101C>T	c.(1099-1101)ATC>ATT	p.I367I		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	367	IgGFc-binding.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TCAGCCCGCTGATAGCCTTCG	0.612		NaN											0	0	0	1	0	20	42				
SPTBN4	57731	broad.mit.edu	37	19	41066206	41066206	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:41066206G>A	uc002ony.2	+	27	5898	c.5812G>A	c.(5812-5814)GTC>ATC	p.V1938I	SPTBN4_uc002onx.2_Missense_Mutation_p.V1938I|SPTBN4_uc002onz.2_Missense_Mutation_p.V1938I|SPTBN4_uc010egx.2_Missense_Mutation_p.V681I|SPTBN4_uc002ooa.2_Missense_Mutation_p.V614I	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	1938	Spectrin 16.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CCGCCTGCATGTCAGCTCCAC	0.647		NaN											0	0	0	1	0	33	120				
CYP2A6	1548	broad.mit.edu	37	19	41352802	41352802	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:41352802G>C	uc002opl.3	-	5	830	c.809C>G	c.(808-810)TCC>TGC	p.S270C	CYP2A6_uc010ehe.1_Missense_Mutation_p.S66C|CYP2A6_uc010ehf.1_RNA	NM_000762	NP_000753	P11509	CP2A6_HUMAN	cytochrome P450, family 2, subfamily A,	270					coumarin catabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|enzyme binding|heme binding			ovary(2)	2			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)		Chlorzoxazone(DB00356)|Diethylstilbestrol(DB00255)|Estradiol(DB00783)|Ethinyl Estradiol(DB00977)|Formoterol(DB00983)|Halothane(DB01159)|Letrozole(DB01006)|Methoxsalen(DB00553)|Metyrapone(DB01011)|Nicotine(DB00184)|Pilocarpine(DB01085)|Tolbutamide(DB01124)|Tranylcypromine(DB00752)	GATGAGAAAGGAGTCAATGAA	0.582		NaN											0	0	0	1	0	9	76				
ZNF574	64763	broad.mit.edu	37	19	42585402	42585402	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:42585402G>C	uc002osm.3	+	2	2813	c.2644G>C	c.(2644-2646)GAG>CAG	p.E882Q	ZNF574_uc002osk.3_Missense_Mutation_p.E972Q	NM_022752	NP_073589	Q6ZN55	ZN574_HUMAN	zinc finger protein 574	882					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.059)				GGAAGCCATTGAGATCTACCC	0.642		NaN											0	0	0	1	0	50	48				
ZNF526	116115	broad.mit.edu	37	19	42728831	42728831	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:42728831G>A	uc002osz.1	+	3	432	c.276G>A	c.(274-276)CAG>CAA	p.Q92Q		NM_133444	NP_597701	Q8TF50	ZN526_HUMAN	zinc finger protein 526	92					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0704)				TGACCACACAGAATGTTGGCC	0.617		NaN											0	0	0	1	0	37	63				
MEGF8	1954	broad.mit.edu	37	19	42837807	42837807	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:42837807G>A	uc002otl.3	+	2	873	c.238G>A	c.(238-240)GAG>AAG	p.E80K		NM_001410	NP_001401	Q7Z7M0	MEGF8_HUMAN	multiple EGF-like-domains 8	80	Extracellular (Potential).|CUB 1.					integral to membrane	calcium ion binding|structural molecule activity			ovary(1)	1		Prostate(69;0.00682)				CCTGGACACAGAGTGCACGTA	0.617		NaN											0	0	0	1	0	21	90				
ZNF45	7596	broad.mit.edu	37	19	44418392	44418392	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:44418392C>T	uc002oxu.1	-	4	1295	c.1196G>A	c.(1195-1197)CGG>CAG	p.R399Q	ZNF45_uc002oxw.1_Missense_Mutation_p.R399Q|ZNF45_uc002oxv.1_Missense_Mutation_p.R399Q	NM_003425	NP_003416	Q02386	ZNF45_HUMAN	zinc finger protein 45	399	C2H2-type 9.				multicellular organismal development	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						ATTTGAGGCCCGGCAGAAGCC	0.502		NaN											0	0	0	1	0	53	85				
ZNF223	7766	broad.mit.edu	37	19	44570825	44570825	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:44570825C>G	uc002oyf.1	+	5	1097	c.844C>G	c.(844-846)CAC>GAC	p.H282D	ZNF284_uc010ejd.2_RNA	NM_013361	NP_037493	Q9UK11	ZN223_HUMAN	zinc finger protein 223	282	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0352)				TCAGAGAATTCACACAGGGGA	0.423		NaN											0	0	0	1	0	112	188				
ZNF223	7766	broad.mit.edu	37	19	44571219	44571219	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:44571219C>G	uc002oyf.1	+	5	1491	c.1238C>G	c.(1237-1239)TCA>TGA	p.S413*	ZNF284_uc010ejd.2_RNA	NM_013361	NP_037493	Q9UK11	ZN223_HUMAN	zinc finger protein 223	413	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Prostate(69;0.0352)				AGACAGGCCTCAAGTATTTTG	0.423		NaN											0	0	0	1	0	13	131				
ERCC1	2067	broad.mit.edu	37	19	45926592	45926592	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:45926592G>A	uc002pbs.1	-	2	187	c.41C>T	c.(40-42)TCA>TTA	p.S14L	ERCC1_uc002pbt.1_Missense_Mutation_p.S14L|ERCC1_uc002pbu.1_Missense_Mutation_p.S14L|ERCC1_uc002pbv.2_Missense_Mutation_p.S14L	NM_001983	NP_001974	P07992	ERCC1_HUMAN	excision repair cross-complementing 1 isofrom 2	14					mitotic recombination|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|response to oxidative stress|transcription-coupled nucleotide-excision repair	cytoplasm|nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair complex	damaged DNA binding|endonuclease activity|protein C-terminus binding|protein domain specific binding|single-stranded DNA binding			ovary(2)	2		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0247)		TGGCGGCCCTGAGGGCTGGGG	0.622		NaN						NER					0	0	0	1	0	5	19				
PNMAL2	57469	broad.mit.edu	37	19	46998632	46998632	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:46998632C>T	uc002pes.2	-	1	538	c.91G>A	c.(91-93)GAG>AAG	p.E31K	uc002peu.1_3'UTR	NM_020709	NP_065760	Q9ULN7	PNML2_HUMAN	PNMA-like 2	31										central_nervous_system(1)	1		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.00233)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		tctgcctgctccaggccctcc	0.03		NaN											0	0	0	1	0	18	65				
PRKD2	25865	broad.mit.edu	37	19	47195050	47195050	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:47195050G>A	uc002pfh.2	-	13	1986	c.1644C>T	c.(1642-1644)GTC>GTT	p.V548V	PRKD2_uc002pfd.2_5'Flank|PRKD2_uc010eks.2_5'Flank|PRKD2_uc010ekt.2_5'UTR|PRKD2_uc002pfe.2_Silent_p.V68V|PRKD2_uc002pff.2_Silent_p.V68V|PRKD2_uc002pfg.2_Silent_p.V391V|PRKD2_uc002pfi.2_Silent_p.V548V|PRKD2_uc002pfj.2_Silent_p.V548V|PRKD2_uc010xye.1_Silent_p.V548V|PRKD2_uc002pfk.2_Silent_p.V391V	NM_001079881	NP_001073350	Q9BZL6	KPCD2_HUMAN	protein kinase D2 isoform A	548					cell death|intracellular signal transduction|positive regulation of transcription from RNA polymerase II promoter|protein autophosphorylation|T cell receptor signaling pathway	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein kinase C activity			ovary(2)|central_nervous_system(2)|stomach(1)|large_intestine(1)|lung(1)	7		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000189)|all cancers(93;0.000545)|Epithelial(262;0.0219)|GBM - Glioblastoma multiforme(486;0.0353)		AGATCTGGTAGACAGTGGCAA	0.577		NaN											0	0	0	1	0	27	57				
GRLF1	2909	broad.mit.edu	37	19	47423316	47423316	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:47423316G>C	uc010ekv.2	+	1	1384	c.1384G>C	c.(1384-1386)GAG>CAG	p.E462Q		NM_004491	NP_004482	Q9NRY4	RHG35_HUMAN	glucocorticoid receptor DNA binding factor 1	462	FF 3.				axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity			central_nervous_system(1)	1		all_cancers(25;1.51e-09)|all_epithelial(76;1.87e-07)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|Ovarian(192;0.0129)|all_neural(266;0.026)|Breast(70;0.077)		all cancers(93;2.03e-05)|OV - Ovarian serous cystadenocarcinoma(262;2.57e-05)|Epithelial(262;0.00135)|GBM - Glioblastoma multiforme(486;0.0289)		TATTATGAATGAGGATTTCTA	0.403		NaN											0	0	0	1	0	17	37				
GRLF1	2909	broad.mit.edu	37	19	47423403	47423403	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:47423403G>C	uc010ekv.2	+	1	1471	c.1471G>C	c.(1471-1473)GAA>CAA	p.E491Q		NM_004491	NP_004482	Q9NRY4	RHG35_HUMAN	glucocorticoid receptor DNA binding factor 1	491	FF 4.				axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity			central_nervous_system(1)	1		all_cancers(25;1.51e-09)|all_epithelial(76;1.87e-07)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|Ovarian(192;0.0129)|all_neural(266;0.026)|Breast(70;0.077)		all cancers(93;2.03e-05)|OV - Ovarian serous cystadenocarcinoma(262;2.57e-05)|Epithelial(262;0.00135)|GBM - Glioblastoma multiforme(486;0.0289)		AGCAAAGGAAGAATTTCAGGA	0.368		NaN											0	0	0	1	0	30	54				
GRLF1	2909	broad.mit.edu	37	19	47424472	47424472	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:47424472G>C	uc010ekv.2	+	1	2540	c.2540G>C	c.(2539-2541)AGA>ACA	p.R847T		NM_004491	NP_004482	Q9NRY4	RHG35_HUMAN	glucocorticoid receptor DNA binding factor 1	847					axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity			central_nervous_system(1)	1		all_cancers(25;1.51e-09)|all_epithelial(76;1.87e-07)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|Ovarian(192;0.0129)|all_neural(266;0.026)|Breast(70;0.077)		all cancers(93;2.03e-05)|OV - Ovarian serous cystadenocarcinoma(262;2.57e-05)|Epithelial(262;0.00135)|GBM - Glioblastoma multiforme(486;0.0289)		TTTAGCATCAGAAAGAGCCGG	0.423		NaN											0	0	0	1	0	65	84				
LIG1	3978	broad.mit.edu	37	19	48640828	48640828	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:48640828G>A	uc002pia.1	-	13	1325	c.1205C>T	c.(1204-1206)TCC>TTC	p.S402F	LIG1_uc010xze.1_Missense_Mutation_p.S95F|LIG1_uc002phz.1_RNA|LIG1_uc002pib.1_RNA|LIG1_uc010xzf.1_Missense_Mutation_p.S334F|LIG1_uc010xzg.1_Missense_Mutation_p.S371F|LIG1_uc010xzh.1_RNA	NM_000234	NP_000225	P18858	DNLI1_HUMAN	DNA ligase I	402					anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			large_intestine(2)|lung(1)	3		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)	GAAGACCCCGGAGGCAGTGAG	0.677		NaN						NER					0	0	0	1	0	33	25				
LIG1	3978	broad.mit.edu	37	19	48643250	48643250	+	Silent	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:48643250G>C	uc002pia.1	-	12	1185	c.1065C>G	c.(1063-1065)CTC>CTG	p.L355L	LIG1_uc010xze.1_Silent_p.L48L|LIG1_uc002phz.1_RNA|LIG1_uc002pib.1_RNA|LIG1_uc010xzf.1_Silent_p.L287L|LIG1_uc010xzg.1_Silent_p.L324L|LIG1_uc010xzh.1_RNA	NM_000234	NP_000225	P18858	DNLI1_HUMAN	DNA ligase I	355					anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			large_intestine(2)|lung(1)	3		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)	CCACTGCCTTGAGAAGGACAC	0.622		NaN						NER					0	0	0	1	0	29	123				
LIG1	3978	broad.mit.edu	37	19	48660322	48660322	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:48660322C>T	uc002pia.1	-	5	439	c.319G>A	c.(319-321)GAC>AAC	p.D107N	LIG1_uc002phz.1_RNA|LIG1_uc002pib.1_RNA|LIG1_uc010xzf.1_Missense_Mutation_p.D107N|LIG1_uc010xzg.1_Missense_Mutation_p.D77N|LIG1_uc010xzh.1_RNA	NM_000234	NP_000225	P18858	DNLI1_HUMAN	DNA ligase I	107					anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			large_intestine(2)|lung(1)	3		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)	GGAGAGGTGTCAGAGAGGGAA	0.577		NaN						NER					0	0	0	1	0	20	136				
PLEKHA4	57664	broad.mit.edu	37	19	49341304	49341304	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:49341304C>G	uc002pkx.2	-	19	2598	c.2047G>C	c.(2047-2049)GAG>CAG	p.E683Q	HSD17B14_uc002pkv.1_5'Flank|HSD17B14_uc010emk.1_5'Flank|PLEKHA4_uc002pkw.1_Nonstop_Mutation_p.*178S|PLEKHA4_uc010eml.2_Nonstop_Mutation_p.*584S	NM_020904	NP_065955	Q9H4M7	PKHA4_HUMAN	pleckstrin homology domain containing family A	683						cytoplasm|membrane	1-phosphatidylinositol binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;0.000108)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00027)|all cancers(93;0.00084)|GBM - Glioblastoma multiforme(486;0.0244)|Epithelial(262;0.0364)		TGCGACGCCTCAGTAGCCAGG	0.542		NaN											0	0	0	1	0	14	94				
GYS1	2997	broad.mit.edu	37	19	49481247	49481247	+	Silent	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:49481247G>C	uc002plp.2	-	10	1483	c.1242C>G	c.(1240-1242)CCC>CCG	p.P414P	GYS1_uc010xzy.1_Silent_p.P47P|GYS1_uc010emm.2_Silent_p.P350P|GYS1_uc010xzz.1_Silent_p.P334P|GYS1_uc010yaa.1_RNA	NM_002103	NP_002094	P13807	GYS1_HUMAN	glycogen synthase 1 (muscle) isoform 1	414					glucose metabolic process|glycogen biosynthetic process	cytosol	glycogen (starch) synthase activity|protein binding			ovary(2)	2		all_lung(116;4.89e-05)|Lung NSC(112;8.3e-05)|all_epithelial(76;8.64e-05)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000164)|all cancers(93;0.000226)|GBM - Glioblastoma multiforme(486;0.00561)|Epithelial(262;0.0286)		TGTTCATGTCGGGAAGGCTCC	0.542		NaN											0	0	0	1	0	13	99				
KLK5	25818	broad.mit.edu	37	19	51452167	51452167	+	Silent	SNP	A	A	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:51452167A>G	uc002pue.2	-	5	758	c.540T>C	c.(538-540)TCT>TCC	p.S180S	KLK5_uc002puf.2_Silent_p.S180S|KLK5_uc002pug.2_Silent_p.S180S	NM_001077491	NP_001070959	Q9Y337	KLK5_HUMAN	kallikrein-related peptidase 5 preproprotein	180	Peptidase S1.				epidermis development|positive regulation of G-protein coupled receptor protein signaling pathway|proteolysis	extracellular space	protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00379)|GBM - Glioblastoma multiforme(134;0.00888)		TTGTCCCAGCAGAGGGACAAT	0.532		NaN											0	0	0	1	0	32	67				
KLK6	5653	broad.mit.edu	37	19	51466738	51466738	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:51466738C>G	uc002pui.2	-	5	525	c.265G>C	c.(265-267)GTT>CTT	p.V89L	KLK6_uc010eoj.2_Intron|KLK6_uc002puh.2_Missense_Mutation_p.V98L|KLK6_uc002puj.2_5'UTR|KLK6_uc010ycn.1_5'UTR|KLK6_uc002pul.2_Missense_Mutation_p.V89L|KLK6_uc002pum.2_5'UTR	NM_001012964	NP_001012982	Q92876	KLK6_HUMAN	kallikrein-related peptidase 6 isoform A	89	Peptidase S1.				amyloid precursor protein metabolic process|central nervous system development|collagen catabolic process|hormone metabolic process|myelination|positive regulation of G-protein coupled receptor protein signaling pathway|protein autoprocessing|proteolysis|regulation of cell differentiation|tissue regeneration	endoplasmic reticulum|extracellular region|microsome|mitochondrion|nucleolus	protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00372)|GBM - Glioblastoma multiforme(134;0.00871)		GCCCGGACAACAGAACTCTGC	0.572		NaN											0	0	0	1	0	13	79				
ZNF836	162962	broad.mit.edu	37	19	52663800	52663800	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:52663800C>T	uc010ydi.1	-	4	434	c.60G>A	c.(58-60)GAG>GAA	p.E20E	ZNF836_uc010ydj.1_Silent_p.E20E	NM_001102657	NP_001096127	Q6ZNA1	ZN836_HUMAN	zinc finger protein 836	20	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ATTTCCACTCCTCCTGAGAGA	0.438		NaN											0	0	0	1	0	55	195				
ZNF534	147658	broad.mit.edu	37	19	52942411	52942411	+	Silent	SNP	G	G	A	rs113700997		TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:52942411G>A	uc002pzk.2	+	4	1798	c.1737G>A	c.(1735-1737)GCG>GCA	p.A579A	ZNF534_uc002pzj.1_Intron|ZNF534_uc010epo.1_Intron|ZNF534_uc002pzl.2_Silent_p.A566A	NM_001143939	NP_001137411	Q76KX8	ZN534_HUMAN	zinc finger protein 534 isoform 2	579	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CACACCTTGCGCGACATAGGA	0.443		NaN											0	0	0	1	0	4	23				
ZNF816A	125893	broad.mit.edu	37	19	53456059	53456059	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:53456059C>G	uc002qal.1	-	4	436	c.135G>C	c.(133-135)CAG>CAC	p.Q45H	ZNF321_uc010eqj.2_Missense_Mutation_p.Q29H|ZNF321_uc002qak.1_Missense_Mutation_p.Q29H|ZNF816A_uc002qam.1_Missense_Mutation_p.Q29H	NM_001031665	NP_001026835	Q0VGE8	ZN816_HUMAN	zinc finger protein 816A	45	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0313)		ATAAAGCCCTCTGTGCAGGGT	0.458		NaN											0	0	0	1	0	85	223				
ZNF665	79788	broad.mit.edu	37	19	53668107	53668107	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:53668107C>T	uc010eqm.1	-	4	1736	c.1636G>A	c.(1636-1638)GAT>AAT	p.D546N		NM_024733	NP_079009	Q9H7R5	ZN665_HUMAN	zinc finger protein 665	481	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.0196)		TTGCCGCAATCATTACATTTG	0.388		NaN											0	0	0	1	0	175	81				
ZNF761	388561	broad.mit.edu	37	19	53958226	53958226	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:53958226G>C	uc010eqp.2	+	7	923	c.465G>C	c.(463-465)CAG>CAC	p.Q155H	ZNF761_uc010ydy.1_Missense_Mutation_p.Q101H|ZNF761_uc002qbt.1_Missense_Mutation_p.Q101H	NM_001008401	NP_001008401	Q86XN6	ZN761_HUMAN	zinc finger protein 761	155					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00786)		ACATATTTCAGACCGAAGAGA	0.388		NaN											0	0	0	1	0	79	210				
CACNG7	59284	broad.mit.edu	37	19	54444867	54444867	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:54444867G>C	uc002qcr.1	+	4	583	c.568G>C	c.(568-570)GAG>CAG	p.E190Q	CACNG7_uc010era.1_Missense_Mutation_p.E190Q	NM_031896	NP_114102	P62955	CCG7_HUMAN	voltage-dependent calcium channel gamma-7	190	Helical; (Potential).				regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(1)	1	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0711)		CCTACTCAAAGAGGTGACGTC	0.443		NaN											0	0	0	1	0	13	182				
TTYH1	57348	broad.mit.edu	37	19	54937898	54937898	+	Silent	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:54937898C>G	uc002qfq.2	+	5	779	c.687C>G	c.(685-687)CTC>CTG	p.L229L	TTYH1_uc010yey.1_Silent_p.L278L|TTYH1_uc002qfr.2_Silent_p.L229L|TTYH1_uc002qft.2_Silent_p.L229L|TTYH1_uc002qfu.1_Silent_p.L141L	NM_020659	NP_065710	Q9H313	TTYH1_HUMAN	tweety 1 isoform 1	229	Helical; Name=3; (Potential).				cell adhesion	chloride channel complex|plasma membrane	chloride channel activity|iron ion transmembrane transporter activity				0	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.0767)		TGGTCTGCCTCTTCACCCTCC	0.647		NaN											0	0	0	1	0	15	102				
NLRP7	199713	broad.mit.edu	37	19	55435133	55435133	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:55435133G>T	uc002qih.3	-	10	2994	c.2918C>A	c.(2917-2919)CCT>CAT	p.P973H	NLRP7_uc002qig.3_Missense_Mutation_p.P1002H|NLRP7_uc002qii.3_Missense_Mutation_p.P1030H|NLRP7_uc010esk.2_3'UTR|NLRP7_uc010esl.2_Missense_Mutation_p.P1058H	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	973							ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		ACAGCACGGAGGTGCCGTTGC	0.463		NaN											1	0	2.24893e-16	1	2.48066e-16	42	82				
RDH13	112724	broad.mit.edu	37	19	55556446	55556446	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:55556446C>G	uc002qio.3	-	7	1177	c.992G>C	c.(991-993)AGA>ACA	p.R331T	RDH13_uc002qip.2_Missense_Mutation_p.R260T|RDH13_uc010esr.1_RNA	NM_001145971	NP_001139443	Q8NBN7	RDH13_HUMAN	retinol dehydrogenase 13 isoform 1	331							binding|oxidoreductase activity			large_intestine(1)|ovary(1)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(297;0.199)	GBM - Glioblastoma multiforme(193;0.0504)	Vitamin A(DB00162)	CAGAGGTTATCTGGGGAGGGG	0.647		NaN											0	0	0	1	0	15	53				
ZNF787	126208	broad.mit.edu	37	19	56600188	56600188	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:56600188C>G	uc010eth.1	-	3	472	c.353G>C	c.(352-354)GGC>GCC	p.G118A		NM_001002836	NP_001002836	Q6DD87	ZN787_HUMAN	zinc finger protein 787	118					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		Colorectal(82;3.46e-05)|Ovarian(87;0.0822)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0559)		GGGCTTCTCGCCCGTGTGGAT	0.682		NaN											0	0	0	1	0	10	12				
ZNF543	125919	broad.mit.edu	37	19	57835137	57835137	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:57835137G>C	uc002qoi.1	+	2	451	c.106G>C	c.(106-108)GAG>CAG	p.E36Q		NM_213598	NP_998763	Q08ER8	ZN543_HUMAN	zinc finger protein 543	36	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)|pancreas(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		CTTGTATCAGGAGGTGATGCT	0.527		NaN											0	0	0	1	0	26	66				
ZNF550	162972	broad.mit.edu	37	19	58058594	58058594	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:58058594C>T	uc002qpe.1	-	2	895	c.895G>A	c.(895-897)GAG>AAG	p.E299K	ZNF547_uc002qpm.3_Intron|ZNF549_uc010eud.1_Intron|ZNF550_uc002qpc.2_RNA|ZNF550_uc010eue.1_RNA|ZNF550_uc002qpd.2_RNA	NM_001039654	NP_001034743	Q7Z398	ZN550_HUMAN	zinc finger protein 550	340					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TAGGGCTTCTCTCCAGTGTGG	0.478		NaN											0	0	0	1	0	12	44				
ZNF544	27300	broad.mit.edu	37	19	58772414	58772414	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:58772414G>C	uc010euo.2	+	7	916	c.442G>C	c.(442-444)GAG>CAG	p.E148Q	ZNF544_uc010yhw.1_Intron|ZNF544_uc010yhx.1_Missense_Mutation_p.E120Q|ZNF544_uc010yhy.1_Missense_Mutation_p.E120Q|ZNF544_uc002qrt.3_Missense_Mutation_p.E6Q|ZNF544_uc002qru.3_Missense_Mutation_p.E6Q|uc002qrx.1_Intron	NM_014480	NP_055295	Q6NX49	ZN544_HUMAN	zinc finger protein 544	148					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		all_cancers(17;4.17e-12)|all_epithelial(17;1.25e-08)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.17)|GBM - Glioblastoma multiforme(193;0.018)		ACTCACCTCAGAGAGACTGTT	0.458		NaN											0	0	0	1	0	28	39				
ZNF544	27300	broad.mit.edu	37	19	58772614	58772614	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr19:58772614G>C	uc010euo.2	+	7	1116	c.642G>C	c.(640-642)GAG>GAC	p.E214D	ZNF544_uc010yhw.1_Intron|ZNF544_uc010yhx.1_Missense_Mutation_p.E186D|ZNF544_uc010yhy.1_Missense_Mutation_p.E186D|ZNF544_uc002qrt.3_Missense_Mutation_p.E72D|ZNF544_uc002qru.3_Missense_Mutation_p.E72D|uc002qrx.1_Intron	NM_014480	NP_055295	Q6NX49	ZN544_HUMAN	zinc finger protein 544	214					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1		all_cancers(17;4.17e-12)|all_epithelial(17;1.25e-08)|Colorectal(82;0.000256)|Lung NSC(17;0.000607)|all_lung(17;0.0024)|all_neural(62;0.0412)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.17)|GBM - Glioblastoma multiforme(193;0.018)		AGCACTGTGAGAGTCATCAGT	0.378		NaN											0	0	0	1	0	22	51				
KIDINS220	57498	broad.mit.edu	37	2	8933973	8933973	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:8933973G>A	uc002qzc.2	-	12	1425	c.1243C>T	c.(1243-1245)CAG>TAG	p.Q415*	KIDINS220_uc010yiv.1_Nonsense_Mutation_p.Q181*|KIDINS220_uc002qzd.2_Nonsense_Mutation_p.Q373*|KIDINS220_uc010yiw.1_Nonsense_Mutation_p.Q416*	NM_020738	NP_065789	Q9ULH0	KDIS_HUMAN	kinase D-interacting substrate of 220 kDa	415	Cytoplasmic (Potential).				activation of MAPKK activity|nerve growth factor receptor signaling pathway	cytosol|integral to membrane				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					ATACTCTTCTGATGGCTACAG	0.358		NaN											0	0	0	1	0	7	70				
NCOA1	8648	broad.mit.edu	37	2	24952432	24952432	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:24952432C>G	uc002rfk.2	+	15	3207	c.2949C>G	c.(2947-2949)ATC>ATG	p.I983M	NCOA1_uc010eye.2_Missense_Mutation_p.I983M|NCOA1_uc002rfi.2_Missense_Mutation_p.I832M|NCOA1_uc002rfj.2_Missense_Mutation_p.I983M|NCOA1_uc002rfl.2_Missense_Mutation_p.I983M	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	983	Interaction with CREBBP.								PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CACCTTTGATCATGGAAGAAA	0.428		NaN	T	PAX3	alveolar rhadomyosarcoma								0	0	0	1	0	29	154				
NCOA1	8648	broad.mit.edu	37	2	24985619	24985619	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:24985619C>G	uc002rfk.2	+	20	4387	c.4129C>G	c.(4129-4131)CTC>GTC	p.L1377V	NCOA1_uc010eye.2_Missense_Mutation_p.L1377V|NCOA1_uc002rfi.2_Missense_Mutation_p.L1226V|NCOA1_uc002rfj.2_Missense_Mutation_p.L1377V|NCOA1_uc002rfl.2_Missense_Mutation_p.L1377V|NCOA1_uc010eyf.2_Intron	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	1377									PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CACTGACCTTCTCAAAACAGA	0.373		NaN	T	PAX3	alveolar rhadomyosarcoma								0	0	0	1	0	51	261				
GPR113	165082	broad.mit.edu	37	2	26532908	26532908	+	Silent	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:26532908C>G	uc002rhe.3	-	13	3144	c.3144G>C	c.(3142-3144)GTG>GTC	p.V1048V	GPR113_uc010yky.1_Intron|GPR113_uc002rhb.1_Intron|GPR113_uc010eyk.1_Intron|GPR113_uc002rhc.1_Intron|GPR113_uc002rhd.1_Intron	NM_001145168	NP_001138640	Q8IZF5	GP113_HUMAN	G-protein coupled receptor 113 isoform 1	1048	Cytoplasmic (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCAGCAACTCACCAGGGAGA	0.572		NaN											0	0	0	1	0	14	76				
C2orf53	339779	broad.mit.edu	37	2	27360495	27360495	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:27360495G>T	uc002rjb.2	-	3	1283	c.703C>A	c.(703-705)CAC>AAC	p.H235N	PREB_uc002rix.1_5'Flank|PREB_uc002riy.1_5'Flank|PREB_uc002riz.1_5'Flank|PREB_uc002rja.1_5'Flank	NM_178553	NP_848648	Q53SZ7	CB053_HUMAN	hypothetical protein LOC339779	235											0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGCCACAGGTGCTGCAAAAGC	0.687		NaN											1	0	1.61879e-10	1	1.73479e-10	12	48				
GTF3C2	2976	broad.mit.edu	37	2	27559164	27559164	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:27559164G>C	uc002rjv.1	-	9	1619	c.1256C>G	c.(1255-1257)TCC>TGC	p.S419C	GTF3C2_uc010eyy.1_5'Flank|GTF3C2_uc002rju.1_Missense_Mutation_p.S430C|GTF3C2_uc002rjw.1_Missense_Mutation_p.S419C|GTF3C2_uc010eyz.1_Missense_Mutation_p.S419C|uc002rjy.1_RNA	NM_001521	NP_001512	Q8WUA4	TF3C2_HUMAN	general transcription factor IIIC, polypeptide	419						transcription factor TFIIIC complex				ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GTCAGGGCTGGAGAAAAGAGC	0.617		NaN											0	0	0	1	0	33	133				
ZNF513	130557	broad.mit.edu	37	2	27603017	27603017	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:27603017C>G	uc002rkk.2	-	2	354	c.154G>C	c.(154-156)GAG>CAG	p.E52Q	ZNF513_uc002rkj.2_5'UTR	NM_144631	NP_653232	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	52	Poly-Glu.				regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCTTCCTCCTCTTCCTCTTCC	0.562		NaN											0	0	0	1	0	17	263				
C2orf16	84226	broad.mit.edu	37	2	27804354	27804354	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:27804354C>T	uc002rkz.3	+	1	4966	c.4915C>T	c.(4915-4917)CGC>TGC	p.R1639C	ZNF512_uc010ylv.1_5'Flank|ZNF512_uc010ylw.1_5'Flank|ZNF512_uc002rlb.2_5'Flank|ZNF512_uc010ylx.1_5'Flank|ZNF512_uc002rlc.2_5'Flank|ZNF512_uc002rla.2_5'Flank|ZNF512_uc010yly.1_5'Flank|ZNF512_uc010ylz.1_5'Flank	NM_032266	NP_115642	Q68DN1	CB016_HUMAN	hypothetical protein LOC84226	1639	27 X 8 AA approximative tandem repeat of P-S-E-R-S-H-H-S.|Arg-rich.									large_intestine(1)	1	Acute lymphoblastic leukemia(172;0.155)					GAGGAGCCATCGCGGTCCCTC	0.577		NaN											0	0	0	1	0	50	297				
SLC4A1AP	22950	broad.mit.edu	37	2	27886635	27886635	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:27886635C>A	uc002rlk.3	+	1	298	c.16C>A	c.(16-18)CGC>AGC	p.R6S	SUPT7L_uc002rlh.1_5'Flank|SUPT7L_uc002rli.1_5'Flank|SUPT7L_uc010ymf.1_5'Flank|SUPT7L_uc002rlj.1_5'Flank|SUPT7L_uc010ezh.1_5'Flank	NM_018158	NP_060628	Q9BWU0	NADAP_HUMAN	solute carrier family 4 (anion exchanger),	6						cytoplasm|nucleus	double-stranded RNA binding|protein binding				0	Acute lymphoblastic leukemia(172;0.155)					AGCACCACTTCGCAACGCTCC	0.517		NaN											1	0	2.2871e-25	1	2.57583e-25	37	164				
BRE	9577	broad.mit.edu	37	2	28248194	28248194	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:28248194G>A	uc002rlr.2	+	6	720	c.402G>A	c.(400-402)GAG>GAA	p.E134E	BRE_uc002rlp.1_Silent_p.E134E|BRE_uc002rlq.2_Silent_p.E134E|BRE_uc002rls.2_Silent_p.E134E|BRE_uc002rlt.2_Silent_p.E134E|BRE_uc002rlu.2_Silent_p.E134E|BRE_uc002rlv.2_5'UTR	NM_199194	NP_954664	Q9NXR7	BRE_HUMAN	brain and reproductive organ-expressed (TNFRSF1A	134	UEV-like 1.				apoptosis|chromatin modification|double-strand break repair|G2/M transition DNA damage checkpoint|positive regulation of anti-apoptosis|positive regulation of DNA repair|response to ionizing radiation|signal transduction	BRCA1-A complex|BRISC complex|cytoplasm|nuclear ubiquitin ligase complex	peroxisome targeting sequence binding|polyubiquitin binding|tumor necrosis factor receptor binding			lung(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					GCCTCCGGGAGAGCTCCCGCC	0.453		NaN											0	0	0	1	0	90	42				
PLB1	151056	broad.mit.edu	37	2	28761192	28761192	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:28761192C>G	uc002rmb.1	+	10	562	c.562C>G	c.(562-564)CTT>GTT	p.L188V	PLB1_uc010ezj.1_Missense_Mutation_p.L199V	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor	188	4 X 308-326 AA approximate repeats.|Extracellular (Potential).|1.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)					ACAGAATGGGCTTGCGGCGGG	0.662		NaN											0	0	0	1	0	5	35				
RASGRP3	25780	broad.mit.edu	37	2	33768679	33768679	+	Missense_Mutation	SNP	T	T	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:33768679T>A	uc002rox.2	+	14	2006	c.1379T>A	c.(1378-1380)GTT>GAT	p.V460D	RASGRP3_uc010ync.1_Missense_Mutation_p.V460D|RASGRP3_uc002roy.2_Missense_Mutation_p.V459D	NM_170672	NP_733772	Q8IV61	GRP3_HUMAN	RAS guanyl releasing protein 3 (calcium and	460	EF-hand 2.				MAPKKK cascade|small GTPase mediated signal transduction	integral to plasma membrane|intracellular	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity|protein binding|Rap GTPase activator activity|signal transducer activity			lung(3)|ovary(1)|pancreas(1)	5	all_hematologic(175;0.115)					TCCTTCTGTGTTCTGGACAAA	0.338		NaN											0	0	0	1	0	5	19				
CRIM1	51232	broad.mit.edu	37	2	36583615	36583615	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:36583615C>T	uc002rpd.2	+	1	219	c.180C>T	c.(178-180)TGC>TGT	p.C60C		NM_016441	NP_057525	Q9NZV1	CRIM1_HUMAN	cysteine-rich motor neuron 1 precursor	60	IGFBP N-terminal.|Extracellular (Potential).				nervous system development|regulation of cell growth	extracellular region|integral to membrane|plasma membrane	insulin-like growth factor binding|insulin-like growth factor receptor activity|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3		all_hematologic(82;0.131)|Acute lymphoblastic leukemia(82;0.154)				AGGGCGTCTGCGGCTGCTGCT	0.697		NaN											0	0	0	1	0	5	44				
C2orf56	55471	broad.mit.edu	37	2	37473327	37473327	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:37473327G>C	uc002rqa.3	+	8	1000	c.925G>C	c.(925-927)GAT>CAT	p.D309H	C2orf56_uc010ynj.1_RNA|C2orf56_uc002rqc.3_Missense_Mutation_p.D211H|C2orf56_uc010ynk.1_Missense_Mutation_p.D238H|C2orf56_uc010ynl.1_Missense_Mutation_p.D282H|C2orf56_uc010fah.2_RNA	NM_144736	NP_653337	Q7L592	MIDA_HUMAN	hypothetical protein LOC55471 isoform 1	309					mitochondrial respiratory chain complex I assembly	mitochondrion	enzyme binding|methyltransferase activity			central_nervous_system(1)	1		all_hematologic(82;0.21)				AACAAAGACAGATACCTTCAG	0.403		NaN											0	0	0	1	0	15	92				
C2orf56	55471	broad.mit.edu	37	2	37474653	37474653	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:37474653C>G	uc002rqa.3	+	9	1066	c.991C>G	c.(991-993)CTA>GTA	p.L331V	C2orf56_uc010ynj.1_RNA|C2orf56_uc002rqc.3_Missense_Mutation_p.L233V|C2orf56_uc010ynk.1_Missense_Mutation_p.L260V|C2orf56_uc010ynl.1_Missense_Mutation_p.L304V|C2orf56_uc010fah.2_RNA	NM_144736	NP_653337	Q7L592	MIDA_HUMAN	hypothetical protein LOC55471 isoform 1	331					mitochondrial respiratory chain complex I assembly	mitochondrion	enzyme binding|methyltransferase activity			central_nervous_system(1)	1		all_hematologic(82;0.21)				AACAGCAGATCTAACAGCTGA	0.398		NaN											0	0	0	1	0	11	175				
LRPPRC	10128	broad.mit.edu	37	2	44161983	44161983	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:44161983C>T	uc002rtr.2	-	24	2597	c.2539G>A	c.(2539-2541)GAC>AAC	p.D847N	LRPPRC_uc010yob.1_Missense_Mutation_p.D747N	NM_133259	NP_573566	P42704	LPPRC_HUMAN	leucine-rich PPR motif-containing protein	847	PPR 13.				mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			ovary(2)|skin(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TCATAGCAGTCAATGGCGACC	0.363		NaN											0	0	0	1	0	10	77				
EPAS1	2034	broad.mit.edu	37	2	46583940	46583940	+	Silent	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:46583940C>G	uc002ruv.2	+	4	935	c.447C>G	c.(445-447)CTC>CTG	p.L149L		NM_001430	NP_001421	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	149	PAS 1.				angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			ovary(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			ACCTGAGTCTCAAAAATGGTA	0.473		NaN											0	0	0	1	0	27	46				
SPTBN1	6711	broad.mit.edu	37	2	54883057	54883057	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:54883057G>T	uc002rxu.2	+	29	6217	c.5968G>T	c.(5968-5970)GAA>TAA	p.E1990*	SPTBN1_uc002rxx.2_Nonsense_Mutation_p.E1977*|SPTBN1_uc002rxy.2_Nonsense_Mutation_p.E135*|SPTBN1_uc010you.1_5'Flank	NM_003128	NP_003119	Q01082	SPTB2_HUMAN	spectrin, beta, non-erythrocytic 1 isoform 1	1990	Spectrin 17.|Interaction with ANK2.				actin filament capping|axon guidance	cytosol|nucleolus|plasma membrane|sarcomere|spectrin	actin binding|calmodulin binding|protein binding|structural constituent of cytoskeleton			ovary(3)|breast(2)|central_nervous_system(2)|skin(1)	8			Lung(47;0.24)			ACAGATCAAGGAAAAATTACT	0.393		NaN											1	0	0.00136819	1	0.00138729	13	31				
CCDC88A	55704	broad.mit.edu	37	2	55559821	55559821	+	Silent	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:55559821C>A	uc002ryv.2	-	16	3578	c.2736G>T	c.(2734-2736)GTG>GTT	p.V912V	CCDC88A_uc010yoz.1_Silent_p.V912V|CCDC88A_uc010ypa.1_Silent_p.V912V|CCDC88A_uc002ryu.2_Silent_p.V195V|CCDC88A_uc002ryw.2_Silent_p.V195V	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	912	Potential.				activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						ACTTTTCACTCACCAAATCCT	0.353		NaN											1	0	3.07112e-06	1	3.19359e-06	10	80				
USP34	9736	broad.mit.edu	37	2	61433904	61433904	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:61433904G>C	uc002sbe.2	-	71	9059	c.9037C>G	c.(9037-9039)CAG>GAG	p.Q3013E	USP34_uc002sbd.2_5'Flank	NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	3013					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			CCTTTTCTCTGAAGATAAGGG	0.378		NaN											0	0	0	1	0	9	48				
C2orf86	51057	broad.mit.edu	37	2	63631244	63631244	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:63631244G>A	uc002sch.2	-	10	1820	c.1374C>T	c.(1372-1374)ATC>ATT	p.I458I	C2orf86_uc002sce.2_RNA|C2orf86_uc002scf.2_Silent_p.I299I|C2orf86_uc010ypu.1_RNA|C2orf86_uc002scg.2_Silent_p.I266I|C2orf86_uc002sci.1_Silent_p.I434I|C2orf86_uc010fcr.1_Silent_p.I348I	NM_015910	NP_056994	O95876	FRITZ_HUMAN	hypothetical protein LOC51057 isoform 2	458					cilium morphogenesis|regulation of embryonic cell shape|regulation of protein localization|septin cytoskeleton organization	cilium axoneme|cytoplasm|cytoskeleton|plasma membrane					0						GGAGATCATAGATATCACTAC	0.393		NaN											0	0	0	1	0	113	55				
UGP2	7360	broad.mit.edu	37	2	64112904	64112904	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:64112904G>C	uc002scm.2	+	6	1063	c.757G>C	c.(757-759)GAT>CAT	p.D253H	UGP2_uc002scl.2_Missense_Mutation_p.D242H|UGP2_uc010ypx.1_Missense_Mutation_p.D262H	NM_006759	NP_006750	Q16851	UGPA_HUMAN	UDP-glucose pyrophosphorylase 2 isoform a	253		Magnesium (By similarity).			glycogen biosynthetic process|phosphorylation|UDP-glucose metabolic process|UDP-glucuronate biosynthetic process|xenobiotic metabolic process	cytosol	metal ion binding|protein binding|UTP:glucose-1-phosphate uridylyltransferase activity				0						GTCTAACATAGATAATCTGGG	0.388		NaN											0	0	0	1	0	31	172				
ATP6V1B1	525	broad.mit.edu	37	2	71189921	71189921	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:71189921T>C	uc002shj.2	+	9	887	c.800T>C	c.(799-801)ATC>ACC	p.I267T	ATP6V1B1_uc010fdv.2_Missense_Mutation_p.I267T|ATP6V1B1_uc010fdw.2_RNA|ATP6V1B1_uc010fdx.2_Missense_Mutation_p.I225T	NM_001692	NP_001683	P15313	VATB1_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1	267					ATP hydrolysis coupled proton transport|calcium ion homeostasis|cellular iron ion homeostasis|excretion|inner ear morphogenesis|insulin receptor signaling pathway|ossification|pH reduction|sensory perception of sound|transferrin transport	apical plasma membrane|basolateral plasma membrane|cytosol|endomembrane system|lateral plasma membrane|microvillus|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			skin(1)	1						GAGCGGATCATCACCCCGCGC	0.587		NaN											0	0	0	1	0	9	116				
DYSF	8291	broad.mit.edu	37	2	71791217	71791217	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:71791217C>T	uc002sie.2	+	24	2761	c.2385C>T	c.(2383-2385)ATC>ATT	p.I795I	DYSF_uc010feg.2_Silent_p.I826I|DYSF_uc010feh.2_Silent_p.I781I|DYSF_uc002sig.3_Silent_p.I781I|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Silent_p.I795I|DYSF_uc010fef.2_Silent_p.I812I|DYSF_uc010fei.2_Silent_p.I812I|DYSF_uc010fek.2_Silent_p.I813I|DYSF_uc010fej.2_Silent_p.I782I|DYSF_uc010fel.2_Silent_p.I782I|DYSF_uc010feo.2_Silent_p.I827I|DYSF_uc010fem.2_Silent_p.I796I|DYSF_uc010fen.2_Silent_p.I813I|DYSF_uc002sif.2_Silent_p.I796I	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	795	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						ACATCGTCATCTGGATGCTGC	0.642		NaN											0	0	0	1	0	28	118				
ALMS1	7840	broad.mit.edu	37	2	73675948	73675948	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:73675948C>T	uc002sje.1	+	10	2408	c.2297C>T	c.(2296-2298)TCA>TTA	p.S766L	ALMS1_uc002sjf.1_Missense_Mutation_p.S722L|ALMS1_uc002sjg.2_Missense_Mutation_p.S152L|ALMS1_uc002sjh.1_Missense_Mutation_p.S152L	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	764	5.|34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						AGTTCTTACTCACAAAGAGAA	0.458		NaN											0	0	0	1	0	134	215				
ALMS1	7840	broad.mit.edu	37	2	73676289	73676289	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:73676289C>T	uc002sje.1	+	10	2749	c.2638C>T	c.(2638-2640)CAT>TAT	p.H880Y	ALMS1_uc002sjf.1_Missense_Mutation_p.H836Y|ALMS1_uc002sjg.2_Missense_Mutation_p.H266Y|ALMS1_uc002sjh.1_Missense_Mutation_p.H266Y	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	878	8.|34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						ACCCAATAGTCATCTAACTGA	0.478		NaN											0	0	0	1	0	54	98				
ALMS1	7840	broad.mit.edu	37	2	73677373	73677373	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:73677373C>G	uc002sje.1	+	10	3833	c.3722C>G	c.(3721-3723)TCA>TGA	p.S1241*	ALMS1_uc002sjf.1_Nonsense_Mutation_p.S1197*|ALMS1_uc002sjg.2_Nonsense_Mutation_p.S627*|ALMS1_uc002sjh.1_Nonsense_Mutation_p.S627*	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1239	15.|34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						GCTTCTTACTCACACACAGAG	0.473		NaN											0	0	0	1	0	70	129				
ALMS1	7840	broad.mit.edu	37	2	73677410	73677410	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:73677410C>T	uc002sje.1	+	10	3870	c.3759C>T	c.(3757-3759)GTC>GTT	p.V1253V	ALMS1_uc002sjf.1_Silent_p.V1209V|ALMS1_uc002sjg.2_Silent_p.V639V|ALMS1_uc002sjh.1_Silent_p.V639V	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1251	16.|34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						ACCAACAGGTCTTGCCAGATA	0.483		NaN											0	0	0	1	0	72	114				
ALMS1	7840	broad.mit.edu	37	2	73677968	73677968	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:73677968C>G	uc002sje.1	+	10	4428	c.4317C>G	c.(4315-4317)TTC>TTG	p.F1439L	ALMS1_uc002sjf.1_Missense_Mutation_p.F1395L|ALMS1_uc002sjg.2_Missense_Mutation_p.F825L|ALMS1_uc002sjh.1_Missense_Mutation_p.F825L	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1437	19.|34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						CTGGTAGTTTCTACCAACAGG	0.488		NaN											0	0	0	1	0	107	180				
ALMS1	7840	broad.mit.edu	37	2	73678719	73678719	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:73678719C>G	uc002sje.1	+	10	5179	c.5068C>G	c.(5068-5070)CTG>GTG	p.L1690V	ALMS1_uc002sjf.1_Missense_Mutation_p.L1646V|ALMS1_uc002sjg.2_Missense_Mutation_p.L1076V|ALMS1_uc002sjh.1_Missense_Mutation_p.L1076V	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1688	25.|34 X 47 AA approximate tandem repeat.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						TGAAGAAGCTCTGAAAGTTCC	0.438		NaN											0	0	0	1	0	60	110				
ALMS1	7840	broad.mit.edu	37	2	73678860	73678860	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:73678860C>G	uc002sje.1	+	10	5320	c.5209C>G	c.(5209-5211)CTG>GTG	p.L1737V	ALMS1_uc002sjf.1_Missense_Mutation_p.L1693V|ALMS1_uc002sjg.2_Missense_Mutation_p.L1123V|ALMS1_uc002sjh.1_Missense_Mutation_p.L1123V	NM_015120	NP_055935	Q8TCU4	ALMS1_HUMAN	Alstrom syndrome 1	1735	34 X 47 AA approximate tandem repeat.|26.				G2/M transition of mitotic cell cycle	centrosome|cilium|cytosol|microtubule basal body|spindle pole				skin(3)|ovary(2)|breast(2)|pancreas(1)|lung(1)	9						TCAAGAAGCTCTGAAAGTTTC	0.423		NaN											0	0	0	1	0	75	120				
LOXL3	84695	broad.mit.edu	37	2	74761668	74761668	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:74761668C>G	uc002smp.1	-	10	1885	c.1813G>C	c.(1813-1815)GAG>CAG	p.E605Q	LOXL3_uc002smo.1_Missense_Mutation_p.E244Q|LOXL3_uc010ffm.1_Missense_Mutation_p.E549Q|LOXL3_uc002smq.1_Missense_Mutation_p.E460Q|LOXL3_uc010ffn.1_Missense_Mutation_p.E460Q	NM_032603	NP_115992	P58215	LOXL3_HUMAN	lysyl oxidase-like 3 precursor	605	Lysyl-oxidase like.					extracellular space|membrane	copper ion binding|protein-lysine 6-oxidase activity|scavenger receptor activity				0						CCATGGCACTCGTGCCACACC	0.607		NaN											0	0	0	1	0	18	13				
C2orf65	130951	broad.mit.edu	37	2	74787419	74787419	+	Splice_Site	SNP	C	C	G	rs77403431		TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:74787419C>G	uc002smy.2	-	9	1399	c.1282_splice	c.e9-1	p.S428_splice	C2orf65_uc010ysa.1_Splice_Site_p.S428_splice|C2orf65_uc010ffp.2_Splice_Site_p.S77_splice|C2orf65_uc002smx.2_Splice_Site_p.S184_splice	NM_138804	NP_620159	Q8TC57	CB065_HUMAN	hypothetical protein LOC130951						chromatin assembly|female gamete generation|RNA processing|spermatogenesis	integral to membrane				ovary(1)|pancreas(1)	2						CCAGCATGCTCTGAGGAAAAG	0.547		NaN											0	0	0	1	0	8	52				
LRRTM1	347730	broad.mit.edu	37	2	80529574	80529574	+	Silent	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:80529574G>T	uc002sok.1	-	2	1641	c.1371C>A	c.(1369-1371)CTC>CTA	p.L457L	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	457	Cytoplasmic (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						TGAGCTGCCTGAGGCTGGCTG	0.557		NaN								HNSCC(69;0.2)			1	0	4.36969e-10	1	4.67295e-10	12	80				
POLR1A	25885	broad.mit.edu	37	2	86315961	86315961	+	Silent	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:86315961G>T	uc002sqs.2	-	5	952	c.573C>A	c.(571-573)CTC>CTA	p.L191L	POLR1A_uc002sqv.2_Silent_p.L191L	NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	191					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						AGAGAGCAATGAGCTTGCTCT	0.448		NaN											1	0	2.35188e-11	1	2.53913e-11	19	91				
KDM3A	55818	broad.mit.edu	37	2	86718100	86718100	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:86718100C>G	uc002sri.3	+	24	3997	c.3670C>G	c.(3670-3672)CAA>GAA	p.Q1224E	KDM3A_uc010ytj.1_Missense_Mutation_p.Q1224E|KDM3A_uc010ytk.1_Missense_Mutation_p.Q1172E	NM_018433	NP_060903	Q9Y4C1	KDM3A_HUMAN	jumonji domain containing 1A	1224	JmjC.				androgen receptor signaling pathway|cell differentiation|formaldehyde biosynthetic process|histone H3-K9 demethylation|hormone-mediated signaling pathway|positive regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	5						ACGTCTTCATCAAGAGTATGG	0.438		NaN											0	0	0	1	0	62	43				
RNF103	7844	broad.mit.edu	37	2	86832071	86832071	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:86832071G>C	uc002srn.2	-	4	1922	c.953C>G	c.(952-954)TCA>TGA	p.S318*	VPS24_uc010ytl.1_Intron|RNF103_uc002srm.2_Nonsense_Mutation_p.S179*|uc002sro.2_Intron	NM_005667	NP_005658	O00237	RN103_HUMAN	ring finger protein 103	318					central nervous system development|ER-associated protein catabolic process	endoplasmic reticulum membrane|integral to membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)	1						GGGTTGTAATGAGCGCAAAAA	0.388		NaN											0	0	0	1	0	21	122				
FER1L5	90342	broad.mit.edu	37	2	97369274	97369274	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:97369274G>A	uc010fia.2	+	50	5814	c.5814G>A	c.(5812-5814)ATG>ATA	p.M1938I	FER1L5_uc002sws.3_Missense_Mutation_p.M647I|FER1L5_uc002swt.3_Missense_Mutation_p.M647I|FER1L5_uc010yus.1_Missense_Mutation_p.M646I	NM_001113382	NP_001106853	A0AVI2	FR1L5_HUMAN	fer-1-like 5 isoform 2	1938						integral to membrane				ovary(1)	1						AGGTGAAGATGAGCCTGGAGA	0.572		NaN											0	0	0	1	0	4	57				
CNNM4	26504	broad.mit.edu	37	2	97427901	97427901	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:97427901G>A	uc002swx.2	+	1	1263	c.1165G>A	c.(1165-1167)GAT>AAT	p.D389N		NM_020184	NP_064569	Q6P4Q7	CNNM4_HUMAN	cyclin M4	389	CBS 1.				biomineral tissue development|ion transport|response to stimulus|visual perception	integral to membrane|plasma membrane				breast(2)|ovary(1)	3						GATCCGCAGCGATGCCATCCT	0.498		NaN											0	0	0	1	0	12	89				
ANKRD36	375248	broad.mit.edu	37	2	97866080	97866080	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:97866080G>A	uc010yva.1	+	45	3009	c.2765G>A	c.(2764-2766)CGG>CAG	p.R922Q	ANKRD36_uc002sxo.2_Missense_Mutation_p.R338Q|ANKRD36_uc002sxp.3_RNA|ANKRD36_uc002sxq.1_RNA	NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	922											0						GTGTCTTCTCGGAAAAAACCA	0.338		NaN											0	0	0	1	0	13	85				
RANBP2	5903	broad.mit.edu	37	2	109388219	109388219	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:109388219C>T	uc002tem.3	+	21	8038	c.7912C>T	c.(7912-7914)CTA>TTA	p.L2638L		NM_006267	NP_006258	P49792	RBP2_HUMAN	RAN binding protein 2	2638	Required for E3 SUMO-ligase activity.|1.|Interaction with UBE2I.|2 X 50 AA approximate repeats.				carbohydrate metabolic process|glucose transport|mitotic prometaphase|mRNA transport|protein folding|protein import into nucleus|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear pore	peptidyl-prolyl cis-trans isomerase activity|Ran GTPase binding|zinc ion binding		RANBP2/ALK(16)	soft_tissue(16)|lung(1)|pancreas(1)	18						TGTATATGAACTAACTCCAAC	0.373		NaN											0	0	0	1	0	32	191				
RABL2A	11159	broad.mit.edu	37	2	114399013	114399013	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:114399013A>G	uc002tkn.3	+	7	704	c.490A>G	c.(490-492)ACC>GCC	p.T164A	RABL2A_uc010flb.2_Missense_Mutation_p.T164A|RABL2A_uc002tkl.3_Missense_Mutation_p.T83A|RABL2A_uc002tkm.3_Missense_Mutation_p.T101A|RABL2A_uc002tks.3_Missense_Mutation_p.T165A|RABL2A_uc002tkr.2_Missense_Mutation_p.T165A|RABL2A_uc002tkp.3_Missense_Mutation_p.T165A	NM_007082	NP_009013	Q9UBK7	RBL2A_HUMAN	RAB, member of RAS oncogene family-like 2A	164					small GTPase mediated signal transduction		GTP binding|GTPase activity			skin(1)	1						TGCTGATGGTACCAATGTTGT	0.498		NaN											0	0	0	1	0	22	71				
CNTNAP5	129684	broad.mit.edu	37	2	125405445	125405445	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:125405445G>A	uc002tno.2	+	13	2348	c.1984G>A	c.(1984-1986)GAA>AAA	p.E662K	CNTNAP5_uc010flu.2_Missense_Mutation_p.E663K	NM_130773	NP_570129	Q8WYK1	CNTP5_HUMAN	contactin associated protein-like 5 precursor	662	Extracellular (Potential).|Fibrinogen C-terminal.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(10)	10				BRCA - Breast invasive adenocarcinoma(221;0.248)		GGGCAGCATGGAACAGCTGGA	0.627		NaN											0	0	0	1	0	4	11				
ERCC3	2071	broad.mit.edu	37	2	128016992	128016992	+	Silent	SNP	T	T	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:128016992T>C	uc002toh.1	-	14	2192	c.2097A>G	c.(2095-2097)GAA>GAG	p.E699E	ERCC3_uc002toe.1_Silent_p.E454E|ERCC3_uc002tof.1_Silent_p.E635E|ERCC3_uc002tog.1_Silent_p.E635E	NM_000122	NP_000113	P19447	ERCC3_HUMAN	excision repair cross-complementing rodent	699	Asp/Glu-rich (acidic).|Helicase C-terminal.				cell cycle checkpoint|DNA topological change|hair cell differentiation|induction of apoptosis|interspecies interaction between organisms|mRNA capping|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA duplex unwinding|nucleotide-excision repair, DNA incision|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|protein localization|response to oxidative stress|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex	3'-5' DNA helicase activity|ATP binding|damaged DNA binding|protein C-terminus binding|protein N-terminus binding|transcription factor binding			ovary(2)|lung(2)|breast(2)|kidney(1)	7	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.073)		ACGCCAAGTCTTCCTCCTCCA	0.572		NaN	Mis|S			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	1	0	39	66				
MYO7B	4648	broad.mit.edu	37	2	128367562	128367562	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:128367562C>G	uc002top.2	+	24	3216	c.3163C>G	c.(3163-3165)CAG>GAG	p.Q1055E		NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	1055	MyTH4 1.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		GCACGGTGCCCAGGTTCCACA	0.657		NaN											0	0	0	1	0	5	11				
NCKAP5	344148	broad.mit.edu	37	2	133542301	133542301	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:133542301C>A	uc002ttp.2	-	14	2457	c.2083G>T	c.(2083-2085)GAG>TAG	p.E695*	NCKAP5_uc002ttq.2_Intron	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	695							protein binding				0						ATGGAAATCTCATTTCTGGTA	0.458		NaN											1	0	1.17739e-12	1	1.28065e-12	25	111				
MCM6	4175	broad.mit.edu	37	2	136603845	136603845	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:136603845G>C	uc002tuw.2	-	15	2247	c.2171C>G	c.(2170-2172)TCT>TGT	p.S724C		NM_005915	NP_005906	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	724					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding				0				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	AATAAGGTTAGAGATTCGGCA	0.483		NaN											0	0	0	1	0	55	38				
EPC2	26122	broad.mit.edu	37	2	149528807	149528807	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:149528807G>A	uc010zbt.1	+	10	1598	c.1571G>A	c.(1570-1572)CGA>CAA	p.R524Q		NM_015630	NP_056445	Q52LR7	EPC2_HUMAN	enhancer of polycomb homolog 2	524					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)|breast(1)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.0516)		AGATCATGTCGACTACAGTGT	0.368		NaN											0	0	0	1	0	72	41				
NEB	4703	broad.mit.edu	37	2	152477516	152477516	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:152477516C>G	uc010fnx.2	-	68	9939	c.9748G>C	c.(9748-9750)GAA>CAA	p.E3250Q		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	3250	Nebulin 88.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTCTTGGCTTCTTCCATGGCC	0.438		NaN											0	0	0	1	0	11	12				
CACNB4	785	broad.mit.edu	37	2	152728976	152728976	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:152728976C>G	uc002tya.2	-	6	621	c.553G>C	c.(553-555)GGA>CGA	p.G185R	CACNB4_uc002txy.2_Missense_Mutation_p.G151R|CACNB4_uc002txz.2_Missense_Mutation_p.G167R|CACNB4_uc010fnz.2_Missense_Mutation_p.G185R|CACNB4_uc002tyb.2_Missense_Mutation_p.G151R	NM_000726	NP_000717	O00305	CACB4_HUMAN	calcium channel, voltage-dependent, beta 4	185					axon guidance|membrane depolarization|synaptic transmission	cytosol|internal side of plasma membrane|plasma membrane|synapse|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(221;0.156)	Verapamil(DB00661)	ACCATTTCTCCAAGACTTGAA	0.358		NaN											0	0	0	1	0	13	102				
GPD2	2820	broad.mit.edu	37	2	157407191	157407191	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:157407191G>A	uc002tzf.3	+	8	1264	c.904G>A	c.(904-906)GAT>AAT	p.D302N	GPD2_uc010zch.1_Missense_Mutation_p.D75N|GPD2_uc002tzd.3_Missense_Mutation_p.D302N|GPD2_uc002tze.1_RNA	NM_001083112	NP_001076581	P43304	GPDM_HUMAN	glycerol-3-phosphate dehydrogenase 2,	302					cellular lipid metabolic process	glycerol-3-phosphate dehydrogenase complex|mitochondrial inner membrane	calcium ion binding|sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity			ovary(1)	1						CAAAATGGATGATAAAGACGC	0.473		NaN											0	0	0	1	0	51	109				
TANC1	85461	broad.mit.edu	37	2	160027154	160027154	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:160027154G>T	uc002uag.2	+	10	1463	c.1189G>T	c.(1189-1191)GAA>TAA	p.E397*	TANC1_uc010fol.1_Nonsense_Mutation_p.E291*|TANC1_uc010zcm.1_Nonsense_Mutation_p.E389*|TANC1_uc010fom.1_Nonsense_Mutation_p.E203*	NM_033394	NP_203752	Q9C0D5	TANC1_HUMAN	tetratricopeptide repeat, ankyrin repeat and	397						cell junction|postsynaptic density|postsynaptic membrane	binding			ovary(2)|central_nervous_system(1)	3						CCAGATAGAAGAAAACTTGAG	0.468		NaN											1	0	7.21436e-19	1	8.04496e-19	21	119				
PLA2R1	22925	broad.mit.edu	37	2	160801453	160801453	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:160801453G>C	uc002ube.1	-	28	4315	c.4108C>G	c.(4108-4110)CAA>GAA	p.Q1370E	PLA2R1_uc010zcp.1_Missense_Mutation_p.Q1368E	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	1370	Extracellular (Potential).|C-type lectin 8.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						TTTTTTTCTTGACACGGGGAT	0.423		NaN											0	0	0	1	0	33	297				
SLC4A10	57282	broad.mit.edu	37	2	162830786	162830786	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:162830786G>C	uc002ubx.3	+	24	3371	c.3187G>C	c.(3187-3189)GAT>CAT	p.D1063H	SLC4A10_uc002uby.3_Missense_Mutation_p.D1033H|SLC4A10_uc010zcs.1_Missense_Mutation_p.D1044H	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	1063	Cytoplasmic (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						AGCTATGGAAGATGAGGGCAC	0.323		NaN											0	0	0	1	0	3	27				
SCN7A	6332	broad.mit.edu	37	2	167313506	167313506	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:167313506C>A	uc002udu.1	-	10	1291	c.1164G>T	c.(1162-1164)TTG>TTT	p.L388F	SCN7A_uc010fpm.1_RNA	NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	388	Helical; Name=S6 of repeat I; (By similarity).				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						TGCCTAAGAACAAACTTGCCA	0.348		NaN											1	0	0.115264	1	0.115264	3	21				
LRP2	4036	broad.mit.edu	37	2	170050365	170050365	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:170050365C>T	uc002ues.2	-	47	8949	c.8736G>A	c.(8734-8736)AAG>AAA	p.K2912K		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2912	LDL-receptor class A 21.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CACCATCACACTTGAACTCAT	0.463		NaN											0	0	0	1	0	29	134				
RAPGEF4	11069	broad.mit.edu	37	2	173891907	173891907	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:173891907G>T	uc002uhv.3	+	25	2665	c.2478G>T	c.(2476-2478)TGG>TGT	p.W826C	RAPGEF4_uc002uhw.3_Missense_Mutation_p.W682C	NM_007023	NP_008954	Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	826	Ras-GEF.				blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.194)			TTCAGTTTTGGGTCGTCACTG	0.373		NaN											1	0	1.20869e-33	1	1.36582e-33	59	7				
PDE11A	50940	broad.mit.edu	37	2	178705092	178705092	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:178705092C>T	uc002ulq.2	-	6	1704	c.1386G>A	c.(1384-1386)GAG>GAA	p.E462E	PDE11A_uc002ulp.2_Silent_p.E18E|PDE11A_uc002ulr.2_Silent_p.E212E|PDE11A_uc002uls.1_Silent_p.E104E|PDE11A_uc002ult.1_Silent_p.E212E|PDE11A_uc002ulu.1_Silent_p.E104E	NM_016953	NP_058649	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A isoform 4	462	GAF 2.				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(3)|large_intestine(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			ATGATGATTTCTCCATGCTTT	0.423		NaN							Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial				0	0	0	1	0	69	1				
PLEKHA3	65977	broad.mit.edu	37	2	179360322	179360322	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:179360322G>C	uc002umn.2	+	5	948	c.550G>C	c.(550-552)GAG>CAG	p.E184Q		NM_019091	NP_061964	Q9HB20	PKHA3_HUMAN	pleckstrin homology domain containing, family A	184						cytoplasm|membrane				ovary(1)|kidney(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0112)|Epithelial(96;0.0266)|all cancers(119;0.0865)			GTTTAAACCTGAGATGTTTCA	0.428		NaN											0	0	0	1	0	22	146				
TTN	7273	broad.mit.edu	37	2	179413724	179413724	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:179413724C>T	uc010zfg.1	-	288	85149	c.84925G>A	c.(84925-84927)GTG>ATG	p.V28309M	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V22004M|TTN_uc010zfi.1_Missense_Mutation_p.V21937M|TTN_uc010zfj.1_Missense_Mutation_p.V21812M	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29236							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTTGTTTTCACACATGCCTCT	0.423		NaN											0	0	0	1	0	49	41				
TTN	7273	broad.mit.edu	37	2	179435376	179435376	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:179435376C>G	uc010zfg.1	-	275	68003	c.67779G>C	c.(67777-67779)AAG>AAC	p.K22593N	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.K16288N|TTN_uc010zfi.1_Missense_Mutation_p.K16221N|TTN_uc010zfj.1_Missense_Mutation_p.K16096N	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	23520							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AGTCGGTGCTCTTTATTTCTA	0.413		NaN											0	0	0	1	0	17	80				
TTN	7273	broad.mit.edu	37	2	179514605	179514605	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:179514605C>G	uc010zfg.1	-	165	32756	c.32532G>C	c.(32530-32532)AAG>AAC	p.K10844N	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc010fre.1_Intron|TTN_uc002umw.1_RNA|TTN_uc002umx.1_5'UTR	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	11771							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGATGATCTTCTTGGGCTCTT	0.338		NaN											0	0	0	1	0	41	78				
NCKAP1	10787	broad.mit.edu	37	2	183817172	183817172	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:183817172G>T	uc002upc.2	-	23	2964	c.2562C>A	c.(2560-2562)AGC>AGA	p.S854R	NCKAP1_uc002upb.2_Missense_Mutation_p.S860R	NM_013436	NP_038464	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1 isoform 1	854					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			GCCACATAAGGCTTTCACTTA	0.313		NaN											1	0	8.00594e-06	1	8.29128e-06	19	63				
SF3B1	23451	broad.mit.edu	37	2	198257718	198257718	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:198257718C>G	uc002uue.2	-	24	3782	c.3734G>C	c.(3733-3735)AGA>ACA	p.R1245T		NM_012433	NP_036565	O75533	SF3B1_HUMAN	splicing factor 3b, subunit 1 isoform 1	1245					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|nuclear speck|U12-type spliceosomal complex	protein binding			pancreas(3)|ovary(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TTGCAACATTCTACATGGTCC	0.294		NaN											0	0	0	1	0	5	32				
KCTD18	130535	broad.mit.edu	37	2	201369515	201369515	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:201369515C>T	uc002uvs.2	-	3	845	c.328G>A	c.(328-330)GAA>AAA	p.E110K	KCTD18_uc002uvt.2_Missense_Mutation_p.E110K|KCTD18_uc002uvu.1_Missense_Mutation_p.E110K	NM_152387	NP_689600	Q6PI47	KCD18_HUMAN	potassium channel tetramerization domain	110						voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)	1						GTCTCCATTTCATTGGCCAAA	0.373		NaN											0	0	0	1	0	7	30				
TRAK2	66008	broad.mit.edu	37	2	202251049	202251049	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:202251049T>C	uc002uyb.3	-	14	2301	c.1855A>G	c.(1855-1857)ACT>GCT	p.T619A		NM_015049	NP_055864	O60296	TRAK2_HUMAN	trafficking protein, kinesin binding 2	619				Missing (in Ref. 2).		early endosome|plasma membrane	GABA receptor binding				0						ACCTGAAAAGTAATACCCTCC	0.463		NaN											0	0	0	1	0	9	69				
NRP2	8828	broad.mit.edu	37	2	206659622	206659622	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:206659622T>C	uc002vaw.2	+	17	3427	c.2636T>C	c.(2635-2637)CTG>CCG	p.L879P	NRP2_uc002vax.2_Missense_Mutation_p.L874P|NRP2_uc002vay.2_Missense_Mutation_p.L857P	NM_201266	NP_957718	O60462	NRP2_HUMAN	neuropilin 2 isoform 1 precursor	879	Helical; (Potential).				angiogenesis|axon guidance|cell adhesion	integral to membrane|membrane fraction|plasma membrane	heparin binding|metal ion binding|semaphorin receptor activity|vascular endothelial growth factor receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4						GGCGTCCTCCTGGGGGCCACC	0.612		NaN											0	0	0	1	0	25	27				
MDH1B	130752	broad.mit.edu	37	2	207621668	207621668	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:207621668C>A	uc002vbs.2	-	4	422	c.367G>T	c.(367-369)GAA>TAA	p.E123*	MDH1B_uc010ziw.1_RNA|MDH1B_uc010fui.2_Nonsense_Mutation_p.E123*|MDH1B_uc010fuj.2_Nonsense_Mutation_p.E25*|MDH1B_uc002vbt.2_RNA	NM_001039845	NP_001034934	Q5I0G3	MDH1B_HUMAN	malate dehydrogenase 1B, NAD (soluble)	123					carbohydrate metabolic process|malate metabolic process|tricarboxylic acid cycle		binding|malate dehydrogenase activity			ovary(3)|kidney(1)	4				LUSC - Lung squamous cell carcinoma(261;0.0763)|Epithelial(149;0.131)|Lung(261;0.145)		TTCAGGGCTTCTTCCTCCTGC	0.428		NaN											1	0	2.80697e-09	1	2.97985e-09	10	28				
ERBB4	2066	broad.mit.edu	37	2	212248420	212248420	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:212248420C>G	uc002veg.1	-	28	3945	c.3847G>C	c.(3847-3849)GAA>CAA	p.E1283Q	ERBB4_uc002veh.1_Missense_Mutation_p.E1267Q|ERBB4_uc010zji.1_Missense_Mutation_p.E1273Q|ERBB4_uc010zjj.1_Missense_Mutation_p.E1257Q	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	1283	Cytoplasmic (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		GAGAGGTATTCAGGATTCTCT	0.502		NaN								TSP Lung(8;0.080)			0	0	0	1	0	11	31				
STK36	27148	broad.mit.edu	37	2	219544719	219544719	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:219544719C>G	uc002viu.2	+	9	1318	c.1052C>G	c.(1051-1053)TCA>TGA	p.S351*	STK36_uc002viv.2_Nonsense_Mutation_p.S351*	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	351					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		CCTCAGGAATCAAGCCTCCTG	0.587		NaN											0	0	0	1	0	21	34				
CCDC108	255101	broad.mit.edu	37	2	219870931	219870931	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:219870931G>C	uc002vjl.1	-	31	4818	c.4734C>G	c.(4732-4734)ATC>ATG	p.I1578M		NM_194302	NP_919278	Q6ZU64	CC108_HUMAN	coiled-coil domain containing 108 isoform 1	1578						integral to membrane	structural molecule activity			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4		Renal(207;0.0915)		Epithelial(149;1.12e-06)|all cancers(144;0.000196)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCTGGTTCTTGATGGGAGGCA	0.607		NaN											0	0	0	1	0	38	8				
SLC16A14	151473	broad.mit.edu	37	2	230911034	230911034	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:230911034G>C	uc002vqd.1	-	4	1171	c.808C>G	c.(808-810)CAG>GAG	p.Q270E	FBXO36_uc010fxi.1_Intron|SLC16A14_uc002vqe.2_Missense_Mutation_p.Q270E|SLC16A14_uc002vqf.2_Missense_Mutation_p.Q270E	NM_152527	NP_689740	Q7RTX9	MOT14_HUMAN	solute carrier family 16 (monocarboxylic acid	270	Extracellular (Potential).					integral to membrane|plasma membrane	symporter activity			ovary(4)|skin(2)	6		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		TGCCCGGCCTGATCGGGGCAC	0.587		NaN											0	0	0	1	0	54	9				
INPP5D	3635	broad.mit.edu	37	2	234072504	234072504	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:234072504C>T	uc010zmo.1	+	11	1545	c.1392C>T	c.(1390-1392)ATC>ATT	p.I464I	INPP5D_uc010zmp.1_Silent_p.I463I	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	464					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		GGCTGGAGATCCTCAAACACT	0.552		NaN											0	0	0	1	0	31	6				
HJURP	55355	broad.mit.edu	37	2	234749322	234749322	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:234749322C>G	uc002vvg.2	-	8	2170	c.2104G>C	c.(2104-2106)GAT>CAT	p.D702H	HJURP_uc010znd.1_Missense_Mutation_p.D641H|HJURP_uc010zne.1_Missense_Mutation_p.D610H	NM_018410	NP_060880	Q8NCD3	HJURP_HUMAN	Holliday junction recognition protein	702					cell cycle|CenH3-containing nucleosome assembly at centromere|centromeric core chromatin assembly|chromosome segregation|regulation of DNA binding|regulation of protein complex assembly	condensed chromosome kinetochore|cytoplasm|nucleolus|nucleoplasm	DNA binding|histone binding			ovary(1)	1		Breast(86;0.00204)|all_lung(227;0.00433)|Renal(207;0.00685)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0719)|Lung SC(224;0.128)		Epithelial(121;2.01e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000186)|Lung(119;0.00521)|LUSC - Lung squamous cell carcinoma(224;0.00829)		TCCACCCCATCTGAGGCACCC	0.577		NaN											0	0	0	1	0	28	36				
SNED1	25992	broad.mit.edu	37	2	242004846	242004846	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr2:242004846G>A	uc002wah.1	+	21	2845	c.2845G>A	c.(2845-2847)GAC>AAC	p.D949N	SNED1_uc002wai.1_Missense_Mutation_p.D184N|SNED1_uc002waj.1_Missense_Mutation_p.D36N|SNED1_uc002wak.2_Missense_Mutation_p.D36N	NM_001080437	NP_001073906	Q8TER0	SNED1_HUMAN	6720455I24Rik homolog precursor	949	Fibronectin type-III 1.				cell-matrix adhesion	extracellular region	calcium ion binding			breast(1)|central_nervous_system(1)	2		all_cancers(19;7.48e-31)|all_epithelial(40;1.35e-12)|Breast(86;0.000148)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.46e-32)|all cancers(36;6.23e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.1e-14)|Kidney(56;6.35e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.98e-08)|BRCA - Breast invasive adenocarcinoma(100;3.66e-06)|Lung(119;0.00072)|LUSC - Lung squamous cell carcinoma(224;0.00553)|Colorectal(34;0.0162)|COAD - Colon adenocarcinoma(134;0.109)		CGTCTCCTCCGACGGCTCCTA	0.647		NaN											0	0	0	1	0	11	20				
C20orf186	149954	broad.mit.edu	37	20	31685467	31685467	+	Silent	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:31685467C>A	uc010zue.1	+	11	1458	c.1443C>A	c.(1441-1443)ATC>ATA	p.I481I		NM_182519	NP_872325	P59827	LPLC4_HUMAN	antimicrobial peptide RY2G5 precursor	481						cytoplasm|extracellular region	lipid binding				0						TCATCAGGATCCAGGTGCTGA	0.597		NaN											1	0	1.39806e-14	1	1.53379e-14	29	256				
C20orf144	128864	broad.mit.edu	37	20	32251484	32251484	+	Silent	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:32251484G>T	uc002wzs.1	+	2	305	c.273G>T	c.(271-273)CCG>CCT	p.P91P	NECAB3_uc002wzl.2_5'Flank|NECAB3_uc002wzm.3_Intron|NECAB3_uc002wzn.3_Intron|NECAB3_uc002wzo.3_Intron|NECAB3_uc002wzp.3_Intron|NECAB3_uc002wzq.3_Intron|NECAB3_uc002wzr.3_Intron|NECAB3_uc010geo.2_Intron|C20orf134_uc002wzt.2_5'Flank	NM_080825	NP_543015	Q9BQM9	CT144_HUMAN	hypothetical protein LOC128864	91											0						AGCGCGAGCCGAGGATGCCGG	0.741		NaN											1	0	0.000157383	1	0.000160863	8	4				
C20orf144	128864	broad.mit.edu	37	20	32251518	32251518	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:32251518G>C	uc002wzs.1	+	2	339	c.307G>C	c.(307-309)GAG>CAG	p.E103Q	NECAB3_uc002wzl.2_5'Flank|NECAB3_uc002wzm.3_Intron|NECAB3_uc002wzn.3_Intron|NECAB3_uc002wzo.3_Intron|NECAB3_uc002wzp.3_Intron|NECAB3_uc002wzq.3_Intron|NECAB3_uc002wzr.3_Intron|NECAB3_uc010geo.2_Intron|C20orf134_uc002wzt.2_5'Flank	NM_080825	NP_543015	Q9BQM9	CT144_HUMAN	hypothetical protein LOC128864	103											0						GCGGCGGCAAGAGGCGCGGCG	0.766		NaN											0	0	0	1	0	2	3				
RALY	22913	broad.mit.edu	37	20	32661429	32661429	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:32661429C>G	uc002xab.2	+	4	615	c.317C>G	c.(316-318)TCT>TGT	p.S106C	RALY_uc010zui.1_Missense_Mutation_p.S106C|RALY_uc002xac.2_Missense_Mutation_p.S106C|RALY_uc002xad.2_RNA|RALY_uc002xae.1_Missense_Mutation_p.S106C	NM_016732	NP_057951	Q9UKM9	RALY_HUMAN	RNA binding protein (autoantigenic,	106						catalytic step 2 spliceosome|heterogeneous nuclear ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(1)	1						AGAGCAGCATCTGCCATATAC	0.517		NaN											0	0	0	1	0	13	66				
MYH7B	57644	broad.mit.edu	37	20	33588881	33588881	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:33588881G>A	uc002xbi.1	+	39	5613	c.5521G>A	c.(5521-5523)GAG>AAG	p.E1841K		NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	myosin, heavy polypeptide 7B, cardiac muscle,	1799	Potential.					membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)			GACGGTGCGCGAGCTCCAGGC	0.637		NaN											0	0	0	1	0	10	53				
CEP250	11190	broad.mit.edu	37	20	34086527	34086527	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:34086527G>T	uc002xcm.2	+	28	4430	c.3759G>T	c.(3757-3759)TGG>TGT	p.W1253C	CEP250_uc010zve.1_Missense_Mutation_p.W621C	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	1253	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			AAGACCTGTGGAAGACTCAAC	0.532		NaN											1	0	2.22156e-40	1	2.51595e-40	82	22				
C20orf4	25980	broad.mit.edu	37	20	34828499	34828499	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:34828499G>C	uc002xfc.1	+	2	802	c.709G>C	c.(709-711)GAG>CAG	p.E237Q	C20orf4_uc002xfd.1_Missense_Mutation_p.E237Q|C20orf4_uc002xfe.1_Missense_Mutation_p.E237Q	NM_015511	NP_056326	Q9Y312	CT004_HUMAN	hypothetical protein LOC25980	237											0	Breast(12;0.0162)	Myeloproliferative disorder(115;0.0393)				CTATGCCCTGGAGACTGTGCT	0.577		NaN											0	0	0	1	0	12	46				
TGIF2	60436	broad.mit.edu	37	20	35207317	35207317	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:35207317C>A	uc002xfn.2	+	2	313	c.140C>A	c.(139-141)TCA>TAA	p.S47*	C20orf24_uc002xfo.2_Nonsense_Mutation_p.S47*	NM_021809	NP_068581	Q9GZN2	TGIF2_HUMAN	TGFB-induced factor homeobox 2	47	Homeobox; TALE-type.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			pancreas(1)|skin(1)	2	Breast(12;0.114)	Myeloproliferative disorder(115;0.00878)				GCCTACCCCTCAGAGCAGGAG	0.517		NaN											1	0	0.000151284	1	0.000155097	12	83				
CTNNBL1	56259	broad.mit.edu	37	20	36431427	36431427	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:36431427G>A	uc010zvw.1	+	12	1281	c.1190G>A	c.(1189-1191)GGA>GAA	p.G397E	CTNNBL1_uc002xhh.2_Missense_Mutation_p.G210E|CTNNBL1_uc002xhi.2_RNA|CTNNBL1_uc002xhj.2_Missense_Mutation_p.G145E	NM_030877	NP_110517	Q8WYA6	CTBL1_HUMAN	beta catenin-like 1	397					apoptosis|positive regulation of apoptosis|somatic diversification of immunoglobulins	nucleus	enzyme binding			ovary(2)	2		Myeloproliferative disorder(115;0.00878)				AAGAAAGTGGGAACCACTGAG	0.428		NaN											0	0	0	1	0	10	26				
RALGAPB	57148	broad.mit.edu	37	20	37191299	37191299	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:37191299G>T	uc002xiw.2	+	24	3913	c.3656G>T	c.(3655-3657)TGG>TTG	p.W1219L	RALGAPB_uc002xix.2_Missense_Mutation_p.W1215L|RALGAPB_uc002xiy.1_Intron|RALGAPB_uc002xiz.2_Missense_Mutation_p.W997L	NM_020336	NP_065069	Q86X10	RLGPB_HUMAN	Ral GTPase activating protein, beta subunit	1219	Rap-GAP.				activation of Ral GTPase activity	intracellular	protein heterodimerization activity|Ral GTPase activator activity			pancreas(1)|skin(1)	2						TCTACCAGTTGGTCTATTAAT	0.403		NaN											1	0	2.59497e-14	1	2.84078e-14	42	43				
SLC32A1	140679	broad.mit.edu	37	20	37353648	37353648	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:37353648C>T	uc002xjc.2	+	1	544	c.281C>T	c.(280-282)CCG>CTG	p.P94L		NM_080552	NP_542119	Q9H598	VIAAT_HUMAN	solute carrier family 32, member 1	94	Cytoplasmic (Potential).				neurotransmitter secretion	clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|integral to membrane|plasma membrane|synaptic vesicle membrane	vesicular hydrogen:amino acid antiporter activity				0		Myeloproliferative disorder(115;0.00878)			Glycine(DB00145)	GCTCCTCTGCCGCCCTCCGGC	0.662		NaN											0	0	0	1	0	13	45				
GTSF1L	149699	broad.mit.edu	37	20	42355269	42355269	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:42355269G>A	uc002xld.2	-	1	374	c.66C>T	c.(64-66)TTC>TTT	p.F22F	GTSF1L_uc002xlc.2_Silent_p.F22F	NM_176791	NP_789761	Q9H1H1	GTSFL_HUMAN	gametocyte specific factor 1-like isoform 1	22	CHHC-type.						metal ion binding				0		Myeloproliferative disorder(115;0.00452)	COAD - Colon adenocarcinoma(18;0.0031)			GGTGGTACTGGAATCTGCTGA	0.493		NaN											0	0	0	1	0	36	87				
KCNS1	3787	broad.mit.edu	37	20	43723710	43723710	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:43723710G>A	uc002xnc.2	-	5	1779	c.1382C>T	c.(1381-1383)TCC>TTC	p.S461F	KCNS1_uc002xnd.2_Missense_Mutation_p.S461F	NM_002251	NP_002242	Q96KK3	KCNS1_HUMAN	potassium voltage-gated channel	461	Cytoplasmic (Potential).					voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity|protein binding				0		Myeloproliferative disorder(115;0.0122)				GTAGAAGTGGGAGAACTTGTT	0.597		NaN											0	0	0	1	0	10	131				
MATN4	8785	broad.mit.edu	37	20	43933045	43933045	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:43933045C>T	uc002xnn.2	-	3	653	c.466G>A	c.(466-468)GAG>AAG	p.E156K	MATN4_uc002xno.2_Missense_Mutation_p.E156K|MATN4_uc002xnp.2_Missense_Mutation_p.E156K|MATN4_uc010zwr.1_Missense_Mutation_p.E104K|MATN4_uc002xnr.1_Missense_Mutation_p.E156K|RBPJL_uc002xns.2_5'Flank|RBPJL_uc002xnt.2_5'Flank	NM_003833	NP_003824	O95460	MATN4_HUMAN	matrilin 4 isoform 1 precursor	156	VWFA 1.					extracellular region	protein binding				0		Myeloproliferative disorder(115;0.0122)				GCCGCCACCTCGGCCACGCGG	0.746		NaN											0	0	0	1	0	4	20				
CEBPB	1051	broad.mit.edu	37	20	48807986	48807986	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:48807986A>G	uc002xvi.1	+	1	611	c.416A>G	c.(415-417)TAC>TGC	p.Y139C	CEBPB_uc002xvh.2_RNA	NM_005194	NP_005185	P17676	CEBPB_HUMAN	CCAAT/enhancer binding protein beta	139					acute-phase response|immune response		sequence-specific enhancer binding RNA polymerase II transcription factor activity				0			BRCA - Breast invasive adenocarcinoma(9;5.72e-08)|STAD - Stomach adenocarcinoma(23;0.19)			GAGTACGGCTACGTGAGCCTG	0.577		NaN											0	0	0	1	0	2	0				
LSM14B	149986	broad.mit.edu	37	20	60708371	60708371	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:60708371G>C	uc010gjy.1	+	8	1218	c.1012G>C	c.(1012-1014)GAG>CAG	p.E338Q	LSM14B_uc002ybv.2_Missense_Mutation_p.E312Q|LSM14B_uc010zzz.1_Missense_Mutation_p.E258Q	NM_144703	NP_653304	Q9BX40	LS14B_HUMAN	LSM14 homolog B	338	TFG box.				multicellular organismal development|regulation of translation	ribonucleoprotein complex					0	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.28e-07)			GTGGGCCGAAGAGAGGAAGCT	0.612		NaN											0	0	0	1	0	34	44				
ZBTB46	140685	broad.mit.edu	37	20	62421402	62421402	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:62421402G>A	uc002ygv.1	-	2	910	c.709C>T	c.(709-711)CAG>TAG	p.Q237*	ZBTB46_uc002ygu.2_RNA	NM_025224	NP_079500	Q86UZ6	ZBT46_HUMAN	zinc finger and BTB domain containing 46	237					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			large_intestine(1)|ovary(1)	2	all_cancers(38;2.09e-12)|all_epithelial(29;3.8e-14)|Lung NSC(23;7.61e-10)|all_lung(23;2.64e-09)					CCTCCGTACTGAGACGGTGAA	0.597		NaN											0	0	0	1	0	4	50				
PRPF6	24148	broad.mit.edu	37	20	62654184	62654184	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:62654184G>C	uc002yho.2	+	13	1890	c.1722G>C	c.(1720-1722)AAG>AAC	p.K574N	PRPF6_uc002yhp.2_Missense_Mutation_p.K574N	NM_012469	NP_036601	O94906	PRP6_HUMAN	PRP6 pre-mRNA processing factor 6 homolog	574	HAT 4.				assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			ovary(2)	2	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					CCAGCAAGAAGAGTGTGTGGC	0.582		NaN											0	0	0	1	0	19	58				
TPTE	7179	broad.mit.edu	37	21	10942732	10942732	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr21:10942732G>C	uc002yip.1	-	13	1077	c.709C>G	c.(709-711)CTA>GTA	p.L237V	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.L219V|TPTE_uc002yir.1_Missense_Mutation_p.L199V|TPTE_uc010gkv.1_Missense_Mutation_p.L99V	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	237	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GTGAGGTCTAGGTCAAATCCA	0.323		NaN											0	0	0	1	0	41	289				
RNF160	26046	broad.mit.edu	37	21	30307437	30307437	+	Silent	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr21:30307437G>T	uc002ymr.2	-	27	5020	c.5007C>A	c.(5005-5007)GGC>GGA	p.G1669G		NM_015565	NP_056380	O94822	LTN1_HUMAN	zinc finger protein 294	1623							ligase activity|zinc ion binding				0						TAACCGTCATGCCATTAAATA	0.313		NaN											1	0	4.36969e-10	1	4.67295e-10	13	47				
USP16	10600	broad.mit.edu	37	21	30419060	30419060	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr21:30419060G>C	uc002ymy.2	+	14	1631	c.1429G>C	c.(1429-1431)GAA>CAA	p.E477Q	USP16_uc002ymx.2_Missense_Mutation_p.E476Q|USP16_uc002ymw.2_Missense_Mutation_p.E477Q|USP16_uc011acm.1_Missense_Mutation_p.E462Q|USP16_uc011acn.1_Missense_Mutation_p.E143Q|USP16_uc011aco.1_Missense_Mutation_p.E167Q	NM_006447	NP_006438	Q9Y5T5	UBP16_HUMAN	ubiquitin specific protease 16 isoform a	477					cell division|histone deubiquitination|mitosis|positive regulation of transcription, DNA-dependent|protein homotetramerization|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|histone binding|transcription coactivator activity|ubiquitin binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(2)|breast(1)|pancreas(1)	4						TGACCATCCTGAAGACAGTGA	0.318		NaN											0	0	0	1	0	9	51				
C21orf63	59271	broad.mit.edu	37	21	33876247	33876247	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr21:33876247G>C	uc002ypr.1	+	7	1281	c.871G>C	c.(871-873)GAC>CAC	p.D291H	C21orf63_uc002yps.1_RNA|C21orf63_uc010glw.1_Missense_Mutation_p.D288H|C21orf63_uc002ypt.1_RNA|C21orf63_uc002ypu.1_Missense_Mutation_p.D196H|C21orf63_uc011adq.1_5'UTR	NM_058187	NP_478067	P58658	CU063_HUMAN	hypothetical protein LOC59271 precursor	291	Extracellular (Potential).					integral to membrane	sugar binding			ovary(2)|pancreas(1)	3						TATAAACTTCGACCCAAGCGG	0.443		NaN											0	0	0	1	0	37	112				
ITSN1	6453	broad.mit.edu	37	21	35147080	35147080	+	Silent	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr21:35147080G>T	uc002yta.1	+	13	1621	c.1353G>T	c.(1351-1353)CGG>CGT	p.R451R	DONSON_uc002ysn.1_Intron|ITSN1_uc002yth.3_RNA|ITSN1_uc002ysz.2_Silent_p.R451R|ITSN1_uc010gmg.2_Silent_p.R414R|ITSN1_uc010gmh.2_RNA|ITSN1_uc002ysw.2_Silent_p.R451R|ITSN1_uc010gmi.2_Silent_p.R414R|ITSN1_uc010gmj.2_Silent_p.R335R|ITSN1_uc002ysy.2_Silent_p.R451R|ITSN1_uc002ysx.2_Silent_p.R414R|ITSN1_uc002ytb.1_Silent_p.R451R|ITSN1_uc002ytc.1_Silent_p.R451R|ITSN1_uc002ytd.2_RNA|ITSN1_uc010gmk.2_Silent_p.R414R|ITSN1_uc010gml.2_RNA|ITSN1_uc002ytj.2_Silent_p.R451R|ITSN1_uc010gmm.1_RNA|ITSN1_uc002yte.2_Silent_p.R385R	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	451	Potential.|KLERQ.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						AGTGGGAACGGAATCGAAGGC	0.368		NaN											1	0	1.5739e-10	1	1.68845e-10	17	43				
RIPK4	54101	broad.mit.edu	37	21	43187192	43187192	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr21:43187192C>G	uc002yzn.1	-	1	58	c.10G>C	c.(10-12)GAC>CAC	p.D4H		NM_020639	NP_065690	P57078	RIPK4_HUMAN	ankyrin repeat domain 3	4						cytoplasm|nucleus	ATP binding|protein serine/threonine kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|skin(1)	7						GTCCCGCCGTCGCCCTCCATC	0.736		NaN											0	0	0	1	0	3	6				
UBASH3A	53347	broad.mit.edu	37	21	43833142	43833142	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr21:43833142C>G	uc002zbe.2	+	4	400	c.364C>G	c.(364-366)CAG>GAG	p.Q122E	UBASH3A_uc002zbf.2_Missense_Mutation_p.Q122E|UBASH3A_uc010gpc.2_RNA|UBASH3A_uc010gpd.2_RNA|UBASH3A_uc010gpe.2_Missense_Mutation_p.Q122E	NM_018961	NP_061834	P57075	UBS3A_HUMAN	ubiquitin associated and SH3 domain containing,	122						cytosol|nucleus				ovary(3)	3						GTGTGAAGACCAGAAGGTGGA	0.512		NaN											0	0	0	1	0	33	141				
RRP1	8568	broad.mit.edu	37	21	45222172	45222172	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr21:45222172G>C	uc002zds.2	+	12	1120	c.1027G>C	c.(1027-1029)GAG>CAG	p.E343Q	RRP1_uc011aez.1_Missense_Mutation_p.E343Q|RRP1_uc010gpk.1_Missense_Mutation_p.E193Q|RRP1_uc010gpl.1_Missense_Mutation_p.E241Q|RRP1_uc010gpm.1_Missense_Mutation_p.E210Q	NM_003683	NP_003674	P56182	RRP1_HUMAN	ribosomal RNA processing 1 homolog	343					rRNA processing	nucleolus|preribosome, small subunit precursor					0				COAD - Colon adenocarcinoma(84;0.00753)|Colorectal(79;0.0157)|STAD - Stomach adenocarcinoma(101;0.171)		CCCTGAAGATGAGATCCCAGA	0.602		NaN											0	0	0	1	0	23	27				
TRAPPC10	7109	broad.mit.edu	37	21	45475622	45475622	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr21:45475622C>G	uc002zea.2	+	5	695	c.526C>G	c.(526-528)CAG>GAG	p.Q176E	TRAPPC10_uc010gpo.2_5'UTR|TRAPPC10_uc002zdz.2_Missense_Mutation_p.Q176E	NM_003274	NP_003265	P48553	TPC10_HUMAN	trafficking protein particle complex 10	176					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			ovary(1)|skin(1)	2						TTCTCGAACTCAGGAATCCTG	0.478		NaN											0	0	0	1	0	91	101				
GAB4	128954	broad.mit.edu	37	22	17468986	17468986	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr22:17468986G>A	uc002zlw.2	-	3	658	c.550C>T	c.(550-552)CAG>TAG	p.Q184*	GAB4_uc010gqs.1_Nonsense_Mutation_p.Q167*	NM_001037814	NP_001032903	Q2WGN9	GAB4_HUMAN	GRB2-associated binding protein family, member	184										large_intestine(1)|ovary(1)	2		all_epithelial(15;0.112)|Lung NSC(13;0.248)				GGGAGGTGCTGATGGGAGCAG	0.612		NaN											0	0	0	1	0	21	19				
PRODH	5625	broad.mit.edu	37	22	18918658	18918658	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr22:18918658C>A	uc010grl.2	-	2	341	c.327G>T	c.(325-327)ATG>ATT	p.M109I	PRODH_uc002zoj.3_5'UTR|PRODH_uc002zol.3_5'UTR|PRODH_uc002zok.3_Missense_Mutation_p.M109I	NM_016335	NP_057419	O43272	PROD_HUMAN	proline dehydrogenase 1	109					glutamate biosynthetic process|induction of apoptosis by oxidative stress|proline catabolic process	mitochondrial inner membrane|mitochondrial matrix	proline dehydrogenase activity			breast(1)	1					L-Proline(DB00172)	AGGTCATCTTCATGAGCTTGT	0.557		NaN											1	0	5.3912e-06	1	5.58905e-06	17	37				
CCDC157	550631	broad.mit.edu	37	22	30766456	30766456	+	Missense_Mutation	SNP	G	G	C	rs5753102		TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr22:30766456G>C	uc011aku.1	+	5	1222	c.562G>C	c.(562-564)GAG>CAG	p.E188Q	CCDC157_uc011akv.1_Missense_Mutation_p.E188Q	NM_001017437	NP_001017437	Q569K6	CC157_HUMAN	coiled-coil domain containing 157	188										central_nervous_system(1)	1						CCAAGAGCCAGAGAGCATCCC	0.602		NaN											0	0	0	1	0	35	33				
INPP5J	27124	broad.mit.edu	37	22	31522449	31522449	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr22:31522449C>A	uc003aju.3	+	3	1451	c.1359C>A	c.(1357-1359)AGC>AGA	p.S453R	INPP5J_uc010gwf.2_Missense_Mutation_p.S453R|INPP5J_uc003ajv.3_Missense_Mutation_p.S86R|INPP5J_uc003ajs.3_Missense_Mutation_p.S86R|INPP5J_uc011alk.1_Missense_Mutation_p.S386R|INPP5J_uc010gwg.2_Missense_Mutation_p.S18R|INPP5J_uc003ajw.2_5'UTR|INPP5J_uc003ajt.3_Missense_Mutation_p.S85R|INPP5J_uc003ajx.2_5'Flank|INPP5J_uc003ajy.2_5'Flank|INPP5J_uc003ajz.2_5'Flank	NM_001002837	NP_001002837	Q15735	PI5PA_HUMAN	phosphatidylinositol (4,5) bisphosphate	453	Catalytic (Potential).					cytoplasm|ruffle	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|SH3 domain binding			skin(1)	1						GTGACGACAGCGACGGCGCAG	0.672		NaN											1	0	1.7881e-09	1	1.90818e-09	30	60				
PISD	23761	broad.mit.edu	37	22	32016599	32016599	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr22:32016599G>T	uc003alm.3	-	7	952	c.945C>A	c.(943-945)TTC>TTA	p.F315L	PISD_uc003alk.2_Missense_Mutation_p.F281L|PISD_uc003all.2_Intron|PISD_uc011alr.1_Missense_Mutation_p.F280L|PISD_uc003aln.3_Intron	NM_014338	NP_055153	Q9UG56	PISD_HUMAN	phosphatidylserine decarboxylase	315					phospholipid biosynthetic process	mitochondrion	phosphatidylserine decarboxylase activity			central_nervous_system(2)|ovary(1)	3					Phosphatidylserine(DB00144)	TCAGTGAGAAGAAGCCATGTT	0.587		NaN											1	0	3.03607e-14	1	3.32009e-14	13	24				
EFCAB6	64800	broad.mit.edu	37	22	43985982	43985982	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr22:43985982C>T	uc003bdy.1	-	24	3219	c.3004G>A	c.(3004-3006)GAA>AAA	p.E1002K	EFCAB6_uc003bdz.1_Missense_Mutation_p.E850K|EFCAB6_uc010gzi.1_Missense_Mutation_p.E850K|EFCAB6_uc010gzj.1_Missense_Mutation_p.E228K	NM_022785	NP_073622	Q5THR3	EFCB6_HUMAN	CAP-binding protein complex interacting protein	1002					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	calcium ion binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	7		Ovarian(80;0.0247)|all_neural(38;0.025)				AGCTCCCCTTCGGTAAGAGAA	0.408		NaN											0	0	0	1	0	31	43				
LRRN1	57633	broad.mit.edu	37	3	3887605	3887605	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:3887605C>G	uc003bpt.3	+	2	2041	c.1280C>G	c.(1279-1281)TCT>TGT	p.S427C	SUMF1_uc003bps.1_Intron	NM_020873	NP_065924	Q6UXK5	LRRN1_HUMAN	leucine rich repeat neuronal 1 precursor	427	Ig-like C2-type.|Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				Epithelial(13;0.000886)|all cancers(10;0.0032)|OV - Ovarian serous cystadenocarcinoma(96;0.00608)|STAD - Stomach adenocarcinoma(44;0.0617)		CCAATGATATCTCACGACAGC	0.502		NaN											0	0	0	1	0	53	66				
SUMF1	285362	broad.mit.edu	37	3	4508701	4508701	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:4508701G>C	uc003bpz.1	-	1	254	c.229C>G	c.(229-231)CCG>GCG	p.P77A	SUMF1_uc003bps.1_RNA|SUMF1_uc011ass.1_Missense_Mutation_p.P77A|SUMF1_uc010hby.1_Missense_Mutation_p.P77A|SUMF1_uc011ast.1_Missense_Mutation_p.P77A	NM_182760	NP_877437	Q8NBK3	SUMF1_HUMAN	sulfatase modifying factor 1 isoform 1	77						endoplasmic reticulum lumen	metal ion binding|oxidoreductase activity			upper_aerodigestive_tract(1)	1		Melanoma(143;0.068)|Colorectal(144;0.233)		Epithelial(13;0.0147)|OV - Ovarian serous cystadenocarcinoma(96;0.0444)|all cancers(10;0.0549)		ACGGGGCCCGGAGCGTTAGCC	0.706		NaN											0	0	0	1	0	3	9				
ITPR1	3708	broad.mit.edu	37	3	4842241	4842241	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:4842241C>T	uc003bqa.2	+	51	7268	c.6920C>T	c.(6919-6921)TCA>TTA	p.S2307L	ITPR1_uc010hca.1_Missense_Mutation_p.S2292L|ITPR1_uc011asu.1_Intron|ITPR1_uc003bqc.2_Missense_Mutation_p.S1277L|ITPR1_uc010hcc.1_Missense_Mutation_p.S75L|ITPR1_uc011asv.1_Missense_Mutation_p.S31L	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	2355	Cytoplasmic (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		CTGATATTTTCAGTCGGGTTA	0.483		NaN											0	0	0	1	0	17	61				
ITPR1	3708	broad.mit.edu	37	3	4856165	4856165	+	Silent	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:4856165G>T	uc003bqa.2	+	55	7824	c.7476G>T	c.(7474-7476)CTG>CTT	p.L2492L	ITPR1_uc010hca.1_Silent_p.L2477L|ITPR1_uc011asu.1_Silent_p.L503L|ITPR1_uc003bqc.2_Silent_p.L1462L|ITPR1_uc010hcc.1_Silent_p.L260L|ITPR1_uc011asv.1_Silent_p.L216L	NM_001099952	NP_001093422	Q14643	ITPR1_HUMAN	inositol 1,4,5-triphosphate receptor, type 1	2540	Lumenal (Potential).				activation of phospholipase C activity|cell death|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	endoplasmic reticulum membrane|integral to membrane|platelet dense granule membrane|platelet dense tubular network membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|intracellular ligand-gated calcium channel activity|phosphatidylinositol binding|protein binding			lung(7)|breast(5)|ovary(4)|large_intestine(1)|liver(1)|skin(1)|kidney(1)|pancreas(1)	21				Epithelial(13;0.0199)|OV - Ovarian serous cystadenocarcinoma(96;0.0361)|all cancers(10;0.0982)		AGACGCTGCTGATGTGCATTG	0.537		NaN											1	0	1.30897e-18	1	1.45808e-18	31	71				
EDEM1	9695	broad.mit.edu	37	3	5241290	5241290	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:5241290C>T	uc003bqi.2	+	3	728	c.596C>T	c.(595-597)TCA>TTA	p.S199L	EDEM1_uc011asz.1_Intron|EDEM1_uc003bqh.2_Missense_Mutation_p.S199L	NM_014674	NP_055489	Q92611	EDEM1_HUMAN	ER degradation enhancer, mannosidase alpha-like	199	Lumenal (Potential).				ER-associated protein catabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	integral to endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			ovary(2)|breast(1)	3				Epithelial(13;0.0588)|OV - Ovarian serous cystadenocarcinoma(96;0.0682)		ATGGGAAATTCATCCGAGTTC	0.408		NaN											0	0	0	1	0	28	28				
MKRN2	23609	broad.mit.edu	37	3	12611602	12611602	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:12611602G>C	uc003bxd.2	+	3	244	c.188G>C	c.(187-189)GGA>GCA	p.G63A	MKRN2_uc003bxe.2_Missense_Mutation_p.G61A|MKRN2_uc011aus.1_Missense_Mutation_p.G20A	NM_014160	NP_054879	Q9H000	MKRN2_HUMAN	makorin ring finger protein 2	63						intracellular	ligase activity|nucleic acid binding|zinc ion binding				0						GCTGCAGCTGGAGGTGCTGTG	0.547		NaN											0	0	0	1	0	23	73				
TRIM71	131405	broad.mit.edu	37	3	32932040	32932040	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:32932040G>A	uc003cff.2	+	4	1407	c.1344G>A	c.(1342-1344)CGG>CGA	p.R448R		NM_001039111	NP_001034200	Q2Q1W2	LIN41_HUMAN	tripartite motif-containing 71	448					multicellular organismal development	cytoplasm	zinc ion binding			ovary(2)|large_intestine(1)	3						AGACCGTGCGGAGCCTCCTGC	0.617		NaN											0	0	0	1	0	27	43				
GLB1	2720	broad.mit.edu	37	3	33109743	33109743	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:33109743G>C	uc003cfi.1	-	4	553	c.436C>G	c.(436-438)CTT>GTT	p.L146V	GLB1_uc003cfh.1_Missense_Mutation_p.L116V|GLB1_uc003cfj.1_Intron|GLB1_uc011axk.1_Missense_Mutation_p.L194V	NM_000404	NP_000395	P16278	BGAL_HUMAN	galactosidase, beta 1 isoform a preproprotein	146					carbohydrate metabolic process	lysosome|perinuclear region of cytoplasm	beta-galactosidase activity|cation binding|protein binding			large_intestine(1)	1		Melanoma(143;0.104)				GAGCGGAGAAGAATAGACTCT	0.383		NaN											0	0	0	1	0	13	39				
CLASP2	23122	broad.mit.edu	37	3	33614798	33614798	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:33614798C>G	uc003cfu.2	-	25	2857	c.2503G>C	c.(2503-2505)GAT>CAT	p.D835H	CLASP2_uc003cfs.2_Missense_Mutation_p.D43H|CLASP2_uc003cft.2_RNA|CLASP2_uc010hgb.2_RNA|CLASP2_uc011axt.1_Missense_Mutation_p.D436H	NM_015097	NP_055912	B2RTR1	B2RTR1_HUMAN	CLIP-associating protein 2	844										ovary(3)|central_nervous_system(1)	4						TTGGCGTCATCATCTGAATGC	0.393		NaN											0	0	0	1	0	32	54				
MLH1	4292	broad.mit.edu	37	3	37035095	37035095	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:37035095C>T	uc003cgl.2	+	1	117	c.57C>T	c.(55-57)ATC>ATT	p.I19I	MLH1_uc011aye.1_5'Flank|EPM2AIP1_uc003cgk.2_5'Flank|MLH1_uc011ayb.1_5'UTR|MLH1_uc010hge.2_Silent_p.I19I|MLH1_uc003cgn.3_5'Flank|MLH1_uc011ayc.1_5'Flank|MLH1_uc011ayd.1_5'Flank|MLH1_uc003cgo.2_5'Flank	NM_000249	NP_000240	P40692	MLH1_HUMAN	MutL protein homolog 1	19			I -> F (in HNPCC2; uncertain pathogenicity).		mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding			large_intestine(40)|haematopoietic_and_lymphoid_tissue(8)|ovary(6)|pancreas(5)|stomach(3)|central_nervous_system(3)|endometrium(3)|breast(3)|prostate(3)|skin(2)|NS(1)	77						TGAACCGCATCGCGGCGGGGG	0.567		1	D|Mis|N|F|S		colorectal|endometrial|ovarian|CNS	colorectal|endometrial|ovarian|CNS		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				0	0	0	1	0	15	34				
GOLGA4	2803	broad.mit.edu	37	3	37368570	37368570	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:37368570G>A	uc003cgv.2	+	14	5497	c.5193G>A	c.(5191-5193)CAG>CAA	p.Q1731Q	GOLGA4_uc010hgr.1_Silent_p.Q1292Q|GOLGA4_uc003cgw.2_Silent_p.Q1753Q|GOLGA4_uc010hgs.2_Intron|GOLGA4_uc003cgx.2_Silent_p.Q1612Q	NM_002078	NP_002069	Q13439	GOGA4_HUMAN	golgi autoantigen, golgin subfamily a, 4	1731	Potential.|Glu-rich.				Golgi to plasma membrane protein transport	Golgi membrane|trans-Golgi network	protein binding			ovary(2)|breast(1)|central_nervous_system(1)	4						GCTGTGTGCAGAAGACATATG	0.373		NaN											0	0	0	1	0	39	104				
OXSR1	9943	broad.mit.edu	37	3	38292922	38292922	+	Silent	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:38292922C>G	uc003chy.2	+	16	1746	c.1404C>G	c.(1402-1404)CTC>CTG	p.L468L	OXSR1_uc010hhb.2_Silent_p.L402L	NM_005109	NP_005100	O95747	OXSR1_HUMAN	oxidative-stress responsive 1	468					intracellular protein kinase cascade|response to oxidative stress		ATP binding|identical protein binding|magnesium ion binding|protein serine/threonine kinase activity			skin(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		CTCAGGAACTCATTTCTGCTG	0.468		NaN											0	0	0	1	0	48	138				
TTC21A	199223	broad.mit.edu	37	3	39166841	39166841	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:39166841G>T	uc003cjc.2	+	11	1411	c.1234G>T	c.(1234-1236)GCC>TCC	p.A412S	TTC21A_uc003cje.2_Missense_Mutation_p.A412S|TTC21A_uc003cjd.2_RNA|TTC21A_uc011ayx.1_Missense_Mutation_p.A363S	NM_145755	NP_665698	Q8NDW8	TT21A_HUMAN	tetratricopeptide repeat domain 21A isoform 2	412							binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		TTTCCTCCAAGCCCTCCTGAT	0.562		NaN									OREG0015487	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	1.75199e-13	1	1.90972e-13	29	28				
CX3CR1	1524	broad.mit.edu	37	3	39307166	39307166	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:39307166C>T	uc003cjl.2	-	2	927	c.835G>A	c.(835-837)GAG>AAG	p.E279K		NM_001337	NP_001328	P49238	CX3C1_HUMAN	chemokine (C-X3-C motif) receptor 1	279	Helical; Name=7; (Potential).				cell adhesion|cellular defense response|chemotaxis|interspecies interaction between organisms|response to wounding	integral to plasma membrane	chemokine receptor activity			lung(3)	3				KIRC - Kidney renal clear cell carcinoma(284;0.0557)|Kidney(284;0.0699)		GCAACCGTCTCAGTCACACTG	0.468		NaN											0	0	0	1	0	39	74				
CCR8	1237	broad.mit.edu	37	3	39374656	39374656	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:39374656G>A	uc010hhr.2	+	2	972	c.834G>A	c.(832-834)CTG>CTA	p.L278L	CCR8_uc003cjm.2_Silent_p.L195L	NM_005201	NP_005192	P51685	CCR8_HUMAN	chemokine (C-C motif) receptor 8	278	Extracellular (Potential).				cell adhesion|chemotaxis|elevation of cytosolic calcium ion concentration|immune response	integral to plasma membrane	coreceptor activity			ovary(1)|lung(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0504)|Kidney(284;0.0635)		GCCAACAGCTGACTTATGCCA	0.433		NaN											0	0	0	1	0	26	30				
NKTR	4820	broad.mit.edu	37	3	42687461	42687461	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:42687461C>T	uc003clo.2	+	17	4530	c.4383C>T	c.(4381-4383)TAC>TAT	p.Y1461Y	NKTR_uc003clp.2_Silent_p.Y1209Y|NKTR_uc011azp.1_Missense_Mutation_p.T272I|NKTR_uc003cls.2_Silent_p.Y1161Y	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	1461					protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		GCAGCAGATACAGTTGAAAAC	0.373		NaN											0	0	0	1	0	5	17				
CCDC13	152206	broad.mit.edu	37	3	42793446	42793446	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:42793446C>G	uc003cly.3	-	5	669	c.585G>C	c.(583-585)CAG>CAC	p.Q195H	CCDC13_uc003clz.2_Missense_Mutation_p.Q195H|CCDC13_uc011azq.1_Missense_Mutation_p.Q195H	NM_144719	NP_653320	Q8IYE1	CCD13_HUMAN	coiled-coil domain containing 13	195	Potential.									ovary(1)	1						TGTCTCCCATCTGGGCCCTCG	0.592		NaN											0	0	0	1	0	6	22				
CYP8B1	1582	broad.mit.edu	37	3	42916916	42916916	+	Silent	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:42916916C>G	uc003cmh.2	-	1	718	c.393G>C	c.(391-393)CTG>CTC	p.L131L	CCBP2_uc003cmd.1_Intron|CCBP2_uc003cmg.2_Intron|CYP8B1_uc010hif.2_Silent_p.L131L	NM_004391	NP_004382	Q9UNU6	CP8B1_HUMAN	cytochrome P450, family 8, subfamily B,	131					bile acid biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase activity|electron carrier activity|heme binding|oxygen binding|sterol 12-alpha-hydroxylase activity			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.213)|Kidney(284;0.249)		CATCCCCCCTCAGATGCTTGG	0.502		NaN											0	0	0	1	0	21	54				
SETD2	29072	broad.mit.edu	37	3	47098400	47098400	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:47098400G>C	uc003cqs.2	-	15	6927	c.6874C>G	c.(6874-6876)CAA>GAA	p.Q2292E	SETD2_uc003cqv.2_Missense_Mutation_p.Q2359E	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	2292	Gln-rich.|Low charge region.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		ATGGTTGCTTGAGACTGTGCA	0.463		NaN	N|F|S|Mis		clear cell renal carcinoma								0	0	0	1	0	23	20		Valid		
C3orf75	54859	broad.mit.edu	37	3	47539889	47539889	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:47539889C>G	uc003crk.2	-	6	678	c.559G>C	c.(559-561)GAT>CAT	p.D187H	C3orf75_uc003crj.2_Missense_Mutation_p.D114H|C3orf75_uc011bba.1_Missense_Mutation_p.D138H|C3orf75_uc003crl.1_Missense_Mutation_p.D187H	NM_001031703	NP_001026873	Q0PNE2	CC075_HUMAN	transmembrane protein 103	187											0						TCCTCCGCATCTCCACTGTCG	0.562		NaN											0	0	0	1	0	28	25				
CELSR3	1951	broad.mit.edu	37	3	48678958	48678958	+	Splice_Site	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:48678958C>T	uc003cul.2	-	33	9106	c.8825_splice	c.e33-1	p.D2942_splice	CELSR3_uc003cuf.1_Splice_Site_p.D3040_splice|CELSR3_uc010hkf.2_Splice_Site_p.D232_splice|CELSR3_uc010hkg.2_Splice_Site_p.D925_splice	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3						homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		CCATCCACATCTGTGGAGCCA	0.597		NaN											0	0	0	1	0	23	17				
CELSR3	1951	broad.mit.edu	37	3	48699135	48699135	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:48699135G>C	uc003cul.2	-	1	1214	c.933C>G	c.(931-933)AAC>AAG	p.N311K	CELSR3_uc003cuf.1_Missense_Mutation_p.N381K	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	311	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		AGCGTGCCCGGTTCGCCGAGG	0.706		NaN											0	0	0	1	0	15	28				
NCKIPSD	51517	broad.mit.edu	37	3	48716150	48716150	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:48716150G>C	uc003cun.2	-	12	1906	c.1812C>G	c.(1810-1812)TTC>TTG	p.F604L	NCKIPSD_uc003cum.2_Missense_Mutation_p.F597L	NM_016453	NP_057537	Q9NZQ3	SPN90_HUMAN	NCK interacting protein with SH3 domain isoform	604					cytoskeleton organization|NLS-bearing substrate import into nucleus|signal transduction	intermediate filament|nucleus	cytoskeletal protein binding|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		GCTCATGTTTGAAGATGCGCA	0.587		NaN											0	0	0	1	0	16	40				
USP19	10869	broad.mit.edu	37	3	49153551	49153551	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:49153551G>C	uc003cwd.1	-	9	1258	c.1097C>G	c.(1096-1098)TCT>TGT	p.S366C	USP19_uc003cwa.2_Missense_Mutation_p.S172C|USP19_uc003cvz.3_Missense_Mutation_p.S467C|USP19_uc011bcg.1_Missense_Mutation_p.S457C|USP19_uc003cwb.2_Missense_Mutation_p.S452C|USP19_uc003cwc.1_Missense_Mutation_p.S122C|USP19_uc011bch.1_Missense_Mutation_p.S467C|USP19_uc011bci.1_Missense_Mutation_p.S452C	NM_006677	NP_006668	O94966	UBP19_HUMAN	ubiquitin thioesterase 19	366	CS 2.|Cytoplasmic (Potential).				ER-associated protein catabolic process|positive regulation of cell cycle process|protein deubiquitination|regulation of protein stability|response to endoplasmic reticulum stress|skeletal muscle atrophy	endoplasmic reticulum membrane|integral to membrane	ubiquitin thiolesterase activity|ubiquitin-specific protease activity|zinc ion binding			ovary(4)|breast(2)|lung(1)	7				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		GTCGATGCGAGAAGCCGTGAA	0.572		NaN											0	0	0	1	0	3	16				
CCDC36	339834	broad.mit.edu	37	3	49293674	49293674	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:49293674G>A	uc003cwk.2	+	10	1131	c.744G>A	c.(742-744)CTG>CTA	p.L248L	CCDC36_uc011bck.1_Silent_p.L248L	NM_178173	NP_835467	Q8IYA8	CCD36_HUMAN	coiled-coil domain containing 36	248										ovary(1)|kidney(1)	2				BRCA - Breast invasive adenocarcinoma(193;9.11e-05)|Kidney(197;0.00248)|KIRC - Kidney renal clear cell carcinoma(197;0.00262)		TAGGCCAGCTGAATGTGCCCA	0.507		NaN											0	0	0	1	0	37	23				
DOCK3	1795	broad.mit.edu	37	3	51418783	51418783	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:51418783C>T	uc011bds.1	+	53	5909	c.5886C>T	c.(5884-5886)GTC>GTT	p.V1962V		NM_004947	NP_004938	Q8IZD9	DOCK3_HUMAN	dedicator of cytokinesis 3	1962						cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00449)|Kidney(197;0.00518)		CAGGGTGCGTCATCCCTCAGG	0.682		NaN											0	0	0	1	0	13	29				
NEK4	6787	broad.mit.edu	37	3	52800388	52800388	+	Missense_Mutation	SNP	A	A	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:52800388A>C	uc003dfq.3	-	3	553	c.364T>G	c.(364-366)TTA>GTA	p.L122V	NEK4_uc011bej.1_Missense_Mutation_p.L33V|NEK4_uc003dfr.2_Missense_Mutation_p.L122V	NM_003157	NP_003148	P51957	NEK4_HUMAN	NIMA-related kinase 4	122	Protein kinase.				cell division|mitosis	nucleus	ATP binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;7.44e-05)|Kidney(197;0.000711)|KIRC - Kidney renal clear cell carcinoma(197;0.00086)|OV - Ovarian serous cystadenocarcinoma(275;0.0513)		TTTTCATGTAAATACTGAGGA	0.333		NaN											0	0	0	1	0	24	15				
CCDC66	285331	broad.mit.edu	37	3	56655611	56655611	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:56655611G>A	uc003dhz.2	+	18	2899	c.2812G>A	c.(2812-2814)GAA>AAA	p.E938K	CCDC66_uc003dhy.2_Missense_Mutation_p.E574K|CCDC66_uc003dhu.2_Missense_Mutation_p.E904K|CCDC66_uc003dhx.2_RNA|CCDC66_uc003dia.2_Missense_Mutation_p.E306K|C3orf63_uc003dib.3_3'UTR|C3orf63_uc003dic.3_3'UTR|C3orf63_uc003die.3_3'UTR|C3orf63_uc003did.3_3'UTR	NM_001141947	NP_001135419	A2RUB6	CCD66_HUMAN	coiled-coil domain containing 66 isoform 1	938										breast(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0478)|Kidney(284;0.0597)|OV - Ovarian serous cystadenocarcinoma(275;0.233)		GCCTTTAGCTGAAAATCAAGA	0.358		NaN											0	0	0	1	0	26	50				
FAM116A	201627	broad.mit.edu	37	3	57631450	57631450	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:57631450G>C	uc003dja.2	-	11	1046	c.975C>G	c.(973-975)TTC>TTG	p.F325L		NM_152678	NP_689891	Q8IWF6	F116A_HUMAN	hypothetical protein LOC201627	325										pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.000621)|KIRC - Kidney renal clear cell carcinoma(284;0.0485)|Kidney(284;0.0607)		AATAAGGTCGGAAATCACTGA	0.343		NaN											0	0	0	1	0	10	29				
PXK	54899	broad.mit.edu	37	3	58395832	58395832	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:58395832G>C	uc003djz.1	+	16	1510	c.1411G>C	c.(1411-1413)GCT>CCT	p.A471P	PXK_uc003djx.1_Missense_Mutation_p.A471P|PXK_uc003djy.1_Missense_Mutation_p.A454P|PXK_uc003dka.1_Missense_Mutation_p.A471P|PXK_uc003dkb.1_Missense_Mutation_p.A388P|PXK_uc003dkc.1_Missense_Mutation_p.A454P|PXK_uc011bfe.1_Missense_Mutation_p.A438P|PXK_uc010hnj.1_Missense_Mutation_p.A438P|PXK_uc003dkd.1_Missense_Mutation_p.A334P|PXK_uc010hnk.1_Missense_Mutation_p.A245P	NM_017771	NP_060241	Q7Z7A4	PXK_HUMAN	PX domain containing serine/threonine kinase	471	Protein kinase.				cell communication|inflammatory response|negative regulation of ATPase activity|negative regulation of ion transport|regulation of synaptic transmission	centrosome|cytoplasm|nucleus|plasma membrane	actin binding|ATP binding|phosphatidylinositol binding|phosphatidylinositol binding|protein C-terminus binding|protein kinase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.000249)|KIRC - Kidney renal clear cell carcinoma(10;0.00346)|Kidney(10;0.00368)|OV - Ovarian serous cystadenocarcinoma(275;0.22)		AAAACGATCTGCTCTTGAAAA	0.408		NaN											0	0	0	1	0	11	15				
OR5H1	26341	broad.mit.edu	37	3	97852408	97852408	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:97852408C>G	uc011bgt.1	+	1	867	c.867C>G	c.(865-867)ATC>ATG	p.I289M		NM_001005338	NP_001005338	A6NKK0	OR5H1_HUMAN	olfactory receptor, family 5, subfamily H,	289	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)	2						ATCCTATCATCTACAGTCTGA	0.343		NaN											0	0	0	1	0	20	84				
OR5K1	26339	broad.mit.edu	37	3	98189098	98189098	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:98189098C>G	uc003dsm.2	+	1	678	c.678C>G	c.(676-678)TTC>TTG	p.F226L		NM_001004736	NP_001004736	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K,	226	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)	1						TTACTATTTTCAAAATGAAAT	0.343		NaN											0	0	0	1	0	75	58				
HHLA2	11148	broad.mit.edu	37	3	108074154	108074154	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:108074154C>G	uc003dwy.3	+	5	778	c.611C>G	c.(610-612)TCA>TGA	p.S204*	HHLA2_uc011bhl.1_Nonsense_Mutation_p.S140*|HHLA2_uc010hpu.2_Nonsense_Mutation_p.S204*|HHLA2_uc003dwz.2_Nonsense_Mutation_p.S204*	NM_007072	NP_009003	Q9UM44	HHLA2_HUMAN	HERV-H LTR-associating 2 precursor	204	Ig-like C1-type.					integral to membrane				ovary(1)	1						ATTACAGGATCAAATTCATCT	0.403		NaN											0	0	0	1	0	52	32				
TRAT1	50852	broad.mit.edu	37	3	108572606	108572606	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:108572606C>G	uc003dxi.1	+	6	587	c.443C>G	c.(442-444)TCT>TGT	p.S148C	TRAT1_uc010hpx.1_Missense_Mutation_p.S111C	NM_016388	NP_057472	Q6PIZ9	TRAT1_HUMAN	T-cell receptor interacting molecule	148	Cytoplasmic (Potential).				cellular defense response|negative regulation of receptor recycling|negative regulation of transport|positive regulation of calcium-mediated signaling|positive regulation of T cell receptor signaling pathway|T cell receptor signaling pathway	integral to plasma membrane|T cell receptor complex	phosphatidylinositol-4,5-bisphosphate 3-kinase activity|transmembrane receptor protein tyrosine kinase adaptor activity			skin(1)	1						GCCAGCGTTTCTAAGACCACC	0.458		NaN											0	0	0	1	0	39	74				
ATP6V1A	523	broad.mit.edu	37	3	113500007	113500007	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:113500007C>G	uc003eao.2	+	3	259	c.193C>G	c.(193-195)CAG>GAG	p.Q65E	ATP6V1A_uc011bik.1_Missense_Mutation_p.Q32E	NM_001690	NP_001681	P38606	VATA_HUMAN	ATPase, H+ transporting, lysosomal V1 subunit A	65					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|integral to plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			ovary(2)|skin(1)	3						GGCTACTATTCAGGTGTATGA	0.378		NaN											0	0	0	1	0	36	107				
KPNA1	3836	broad.mit.edu	37	3	122160940	122160940	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:122160940G>C	uc003efd.1	-	10	977	c.941C>G	c.(940-942)TCT>TGT	p.S314C	KPNA1_uc003efb.1_Missense_Mutation_p.S113C|KPNA1_uc003efc.1_Missense_Mutation_p.S113C|KPNA1_uc011bjr.1_Missense_Mutation_p.S113C|KPNA1_uc010hrh.2_Missense_Mutation_p.S113C|KPNA1_uc003efe.2_Missense_Mutation_p.S314C	NM_002264	NP_002255	P52294	IMA1_HUMAN	karyopherin alpha 1	314	Binding to RAG1.|ARM 6.				DNA fragmentation involved in apoptotic nuclear change|NLS-bearing substrate import into nucleus|regulation of DNA recombination|viral genome transport in host cell|viral infectious cycle	cytosol|nuclear pore|nucleoplasm	nuclear localization sequence binding|protein binding|protein transporter activity				0				GBM - Glioblastoma multiforme(114;0.0898)		CAAAGCAGGAGAAACCACTTT	0.338		NaN											0	0	0	1	0	25	150				
ADCY5	111	broad.mit.edu	37	3	123166643	123166643	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:123166643C>T	uc003egh.1	-	1	750	c.750G>A	c.(748-750)GTG>GTA	p.V250V		NM_183357	NP_899200	O95622	ADCY5_HUMAN	adenylate cyclase 5	250	Helical; (Potential).				activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	adenylate cyclase activity|ATP binding|metal ion binding			ovary(4)	4				GBM - Glioblastoma multiforme(114;0.0342)		GGCACACGAGCACCAGCACGG	0.662		NaN											0	0	0	1	0	8	30				
HEG1	57493	broad.mit.edu	37	3	124748209	124748209	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:124748209G>A	uc003ehs.3	-	2	508	c.440C>T	c.(439-441)TCT>TTT	p.S147F	HEG1_uc011bke.1_Missense_Mutation_p.S147F	NM_020733	NP_065784	Q9ULI3	HEG1_HUMAN	HEG homolog 1 precursor	147	Extracellular (Potential).					extracellular region|integral to membrane	calcium ion binding			ovary(2)	2						GCTCTTCCCAGAGGTCTGAAC	0.483		NaN											0	0	0	1	0	20	45				
PLXNA1	5361	broad.mit.edu	37	3	126707544	126707544	+	Silent	SNP	T	T	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:126707544T>G	uc003ejg.2	+	1	43	c.39T>G	c.(37-39)GGT>GGG	p.G13G		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	36	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		CAGGCGGGGGTTCACAGCCCC	0.567		NaN											0	0	0	1	0	11	20				
H1FOO	132243	broad.mit.edu	37	3	129269986	129269986	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:129269986G>C	uc003emu.2	+	5	849	c.844G>C	c.(844-846)GTG>CTG	p.V282L	H1FOO_uc003emv.2_Missense_Mutation_p.V143L	NM_153833	NP_722575	Q8IZA3	H1FOO_HUMAN	H1 histone family, member O, oocyte-specific	282					meiosis|nucleosome assembly	cytoplasm|nucleosome	DNA binding			skin(1)	1						CAAAAAGAAGGTGGTGGCCAA	0.408		NaN											0	0	0	1	0	15	53				
NUDT16	131870	broad.mit.edu	37	3	131101103	131101103	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:131101103G>C	uc003eof.2	+	2	294	c.253G>C	c.(253-255)GAG>CAG	p.E85Q	uc003eoc.1_5'Flank|NUDT16_uc011bln.1_Missense_Mutation_p.E72Q|NUDT16_uc003eog.1_Missense_Mutation_p.E85Q	NM_152395	NP_689608	Q96DE0	NUD16_HUMAN	nudix-type motif 16	118	Nudix hydrolase.					nucleolus|nucleoplasm	hydrolase activity|metal ion binding|RNA binding				0						TCTGACGCTCGAGGAGCTGTT	0.657		NaN											0	0	0	1	0	13	38				
PCOLCE2	26577	broad.mit.edu	37	3	142606552	142606552	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:142606552C>T	uc003evd.2	-	2	347	c.151G>A	c.(151-153)GGA>AGA	p.G51R		NM_013363	NP_037495	Q9UKZ9	PCOC2_HUMAN	procollagen C-endopeptidase enhancer 2	51	CUB 1.					extracellular region	collagen binding|heparin binding|peptidase activator activity			ovary(2)|skin(1)	3						GGGTACACTCCAGGAAAACCT	0.398		NaN											0	0	0	1	0	19	30				
MLF1	4291	broad.mit.edu	37	3	158314723	158314723	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:158314723G>C	uc003fcb.2	+	3	405	c.268G>C	c.(268-270)GAA>CAA	p.E90Q	MLF1_uc003fbz.2_Missense_Mutation_p.E65Q|MLF1_uc003fca.2_Missense_Mutation_p.E65Q|MLF1_uc003fbx.2_Missense_Mutation_p.E80Q|MLF1_uc003fcc.2_Missense_Mutation_p.E121Q|MLF1_uc003fby.2_Missense_Mutation_p.E16Q|MLF1_uc010hvx.2_Missense_Mutation_p.E65Q	NM_022443	NP_071888	P58340	MLF1_HUMAN	myeloid leukemia factor 1 isoform 1	90	Interaction with COPS3.				cell cycle arrest|myeloid progenitor cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein domain specific binding				0		Melanoma(1037;0.000458)|Prostate(884;0.0235)|all_neural(597;0.0299)	Lung(72;0.00199)|LUSC - Lung squamous cell carcinoma(72;0.00256)			GCAGAAATTAGAAAGAAACTT	0.264		NaN	T	NPM1	AML								0	0	0	1	0	20	6				
SMC4	10051	broad.mit.edu	37	3	160150149	160150149	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:160150149G>C	uc003fdh.2	+	22	3489	c.3376G>C	c.(3376-3378)GAT>CAT	p.D1126H	IFT80_uc003fda.2_Intron|SMC4_uc003fdi.2_Missense_Mutation_p.D1101H|SMC4_uc003fdj.2_Missense_Mutation_p.D1126H|SMC4_uc010hwd.2_Missense_Mutation_p.D1068H|SMC4_uc003fdl.2_Missense_Mutation_p.D829H	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes	1126	Potential.				cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			GGCATATGAAGATCTTCGGAA	0.338		NaN											0	0	0	1	0	16	65				
PPM1L	151742	broad.mit.edu	37	3	160786817	160786817	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:160786817G>A	uc003fdr.2	+	4	1056	c.955G>A	c.(955-957)GAG>AAG	p.E319K	PPM1L_uc003fds.2_Missense_Mutation_p.E140K|PPM1L_uc003fdt.2_Missense_Mutation_p.E192K|PPM1L_uc010hwf.2_RNA	NM_139245	NP_640338	Q5SGD2	PPM1L_HUMAN	protein phosphatase 1 (formerly 2C)-like	319	Cytoplasmic (Potential).|PP2C-like.				protein dephosphorylation|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			breast(1)	1			Lung(72;0.00149)|LUSC - Lung squamous cell carcinoma(72;0.00216)			ATTCATCAAGGAGCGCTTGGA	0.468		NaN											0	0	0	1	0	58	45				
PRKCI	5584	broad.mit.edu	37	3	170020896	170020896	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:170020896C>G	uc003fgs.2	+	18	2010	c.1772C>G	c.(1771-1773)TCT>TGT	p.S591C	PRKCI_uc003fgt.2_Missense_Mutation_p.S146C	NM_002740	NP_002731	P41743	KPCI_HUMAN	protein kinase C, iota	591	AGC-kinase C-terminal.				anti-apoptosis|cellular membrane organization|cellular response to insulin stimulus|establishment or maintenance of epithelial cell apical/basal polarity|intracellular signal transduction|nerve growth factor receptor signaling pathway|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|protein targeting to membrane|secretion|tight junction assembly|vesicle-mediated transport	cytosol|endosome|nucleus|polarisome	ATP binding|phospholipid binding|protein binding|protein kinase C activity|zinc ion binding			lung(2)|ovary(1)|breast(1)|skin(1)	5	all_cancers(22;6.45e-23)|all_epithelial(15;8.52e-28)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			CTTTTGATGTCTGCAGAAGAA	0.333		NaN											0	0	0	1	0	8	40				
SKIL	6498	broad.mit.edu	37	3	170108880	170108880	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:170108880G>C	uc003fgu.2	+	6	2440	c.1728G>C	c.(1726-1728)CAG>CAC	p.Q576H	SKIL_uc011bps.1_Missense_Mutation_p.Q556H|SKIL_uc003fgv.2_Missense_Mutation_p.Q530H|SKIL_uc003fgw.2_Missense_Mutation_p.Q576H	NM_005414	NP_005405	P12757	SKIL_HUMAN	SKI-like isoform 1	576	Potential.				cell cycle arrest|negative regulation of cell differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of axonogenesis|protein heterotrimerization|protein homotrimerization|regulation of apoptosis|regulation of apoptosis|response to antibiotic|response to growth factor stimulus|skeletal muscle tissue development	cytoplasm|PML body	chromatin binding|nucleotide binding|protein complex binding|protein domain specific binding|SMAD binding|transcription corepressor activity|transcription repressor activity			ovary(2)|skin(1)	3	all_cancers(22;7.13e-23)|all_epithelial(15;9.95e-28)|all_lung(20;1.23e-16)|Lung NSC(18;5.15e-16)|Ovarian(172;0.000337)|Breast(254;0.137)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.197)			AAGAACAGCAGAATTTACAGA	0.313		NaN											0	0	0	1	0	31	10				
PIK3CA	5290	broad.mit.edu	37	3	178936082	178936082	+	Missense_Mutation	SNP	G	G	A	rs121913273		TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:178936082G>A	uc003fjk.2	+	10	1781	c.1624G>A	c.(1624-1626)GAA>AAA	p.E542K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	542	PI3K helical.		E -> V (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation).|E -> Q (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E542K(481)|p.E542V(8)|p.E542Q(6)|p.E542G(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TCCTCTCTCTGAAATCACTGA	0.333	E542K(SW948_LARGE_INTESTINE)|E542K(T84_LARGE_INTESTINE)|E542K(CAL51_BREAST)|E542K(JHUEM1_ENDOMETRIUM)|E542K(NCIH1341_LUNG)|E542K(VMCUB1_URINARY_TRACT)|E542K(BT483_BREAST)|E542K(HGC27_STOMACH)|E542K(IM95_STOMACH)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	1	0	25	84		Valid		
MCF2L2	23101	broad.mit.edu	37	3	183097188	183097188	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:183097188C>G	uc003fli.1	-	3	262	c.172G>C	c.(172-174)GAG>CAG	p.E58Q	MCF2L2_uc003flj.1_Missense_Mutation_p.E58Q|MCF2L2_uc003flp.1_Missense_Mutation_p.E93Q	NM_015078	NP_055893	Q86YR7	MF2L2_HUMAN	Rho family guanine-nucleotide exchange factor	58	CRAL-TRIO.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)|large_intestine(2)|breast(1)	5	all_cancers(143;1.26e-12)|Ovarian(172;0.0355)		all cancers(12;3.35e-44)|Epithelial(37;6.48e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			GCGCCATCCTCCCCTCGGCCT	0.512		NaN											0	0	0	1	0	23	9				
CHRD	8646	broad.mit.edu	37	3	184107170	184107170	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:184107170G>A	uc003fov.2	+	23	3074	c.2828G>A	c.(2827-2829)AGA>AAA	p.R943K	CHRD_uc003fow.2_Missense_Mutation_p.R573K|CHRD_uc003fox.2_Missense_Mutation_p.R942K|CHRD_uc003foy.2_Missense_Mutation_p.R573K|CHRD_uc010hyc.2_Missense_Mutation_p.R533K|CHRD_uc011brr.1_Missense_Mutation_p.R485K	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	943					BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CCAGAGACCAGAACTGATCCA	0.512		NaN											0	0	0	1	0	6	13				
AHSG	197	broad.mit.edu	37	3	186334313	186334313	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:186334313C>G	uc003fqk.3	+	3	487	c.406C>G	c.(406-408)CCA>GCA	p.P136A	AHSG_uc003fqj.2_Missense_Mutation_p.P136A|AHSG_uc003fql.3_Missense_Mutation_p.P136A|AHSG_uc003fqm.3_Missense_Mutation_p.P135A|AHSG_uc010hyp.2_Missense_Mutation_p.P99A	NM_001622	NP_001613	P02765	FETUA_HUMAN	alpha-2-HS-glycoprotein	136					acute-phase response|negative regulation of bone mineralization|negative regulation of insulin receptor signaling pathway|pinocytosis|positive regulation of phagocytosis|regulation of inflammatory response|skeletal system development	extracellular space	cysteine-type endopeptidase inhibitor activity|protein binding				0	all_cancers(143;3.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.27e-20)	GBM - Glioblastoma multiforme(93;0.0463)		TGATTCCAGTCCAGGTACAGA	0.413		NaN											0	0	0	1	0	4	20				
CLDN16	10686	broad.mit.edu	37	3	190120206	190120206	+	Silent	SNP	T	T	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:190120206T>C	uc003fsi.2	+	2	473	c.405T>C	c.(403-405)GAT>GAC	p.D135D	CLDN16_uc010hze.2_Intron	NM_006580	NP_006571	Q9Y5I7	CLD16_HUMAN	claudin 16	135	Extracellular (Potential).				calcium-independent cell-cell adhesion|cellular metal ion homeostasis|excretion	integral to membrane|tight junction	identical protein binding|magnesium ion transmembrane transporter activity|structural molecule activity			ovary(1)	1	all_cancers(143;3.61e-10)|Ovarian(172;0.0991)		Lung(62;2.23e-05)|LUSC - Lung squamous cell carcinoma(58;3.15e-05)	GBM - Glioblastoma multiforme(93;0.018)		ATGAGTACGATTCCATACTTG	0.488		NaN											0	0	0	1	0	28	89				
LSG1	55341	broad.mit.edu	37	3	194371614	194371614	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:194371614G>C	uc003fui.2	-	10	1730	c.1415C>G	c.(1414-1416)TCA>TGA	p.S472*		NM_018385	NP_060855	Q9H089	LSG1_HUMAN	large subunit GTPase 1	472					nuclear export|protein transport	Cajal body|endoplasmic reticulum	GTP binding|hydrolase activity				0	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;4.34e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;7.55e-06)		GGATATTAGTGATACAGGAGG	0.418		NaN											0	0	0	1	0	25	49				
PPP1R2	5504	broad.mit.edu	37	3	195251628	195251628	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:195251628G>A	uc003fup.2	-	3	673	c.297C>T	c.(295-297)ATC>ATT	p.I99I		NM_006241	NP_006232	P41236	IPP2_HUMAN	protein phosphatase 1, regulatory subunit 2	99					glycogen metabolic process|regulation of phosphoprotein phosphatase activity|regulation of signal transduction		protein binding|protein serine/threonine phosphatase inhibitor activity			urinary_tract(1)	1	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)		Epithelial(36;2.64e-22)|all cancers(36;2.69e-20)|OV - Ovarian serous cystadenocarcinoma(49;3.52e-19)|Lung(62;0.000104)|LUSC - Lung squamous cell carcinoma(58;0.000128)	GBM - Glioblastoma multiforme(46;9.55e-05)		TCCTGGCTAAGATGTCTGGCG	0.468		NaN											0	0	0	1	0	21	33				
CRMP1	1400	broad.mit.edu	37	4	5851128	5851128	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:5851128C>G	uc003gip.2	-	7	713	c.612G>C	c.(610-612)TTG>TTC	p.L204F	CRMP1_uc003gin.1_Missense_Mutation_p.L116F|CRMP1_uc003giq.2_Missense_Mutation_p.L204F|CRMP1_uc003gir.2_Missense_Mutation_p.L199F|CRMP1_uc003gis.2_Missense_Mutation_p.L318F	NM_001313	NP_001304	Q14194	DPYL1_HUMAN	collapsin response mediator protein 1 isoform 2	204					axon guidance|pyrimidine base catabolic process	cytosol|microtubule organizing center|spindle	dihydropyrimidinase activity|protein binding			ovary(2)	2				Colorectal(103;0.0721)		CCTGAGCTATCAAATCTCCAT	0.458		NaN											0	0	0	1	0	15	59				
BOD1L	259282	broad.mit.edu	37	4	13604756	13604756	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:13604756C>G	uc003gmz.1	-	10	3885	c.3768G>C	c.(3766-3768)TTG>TTC	p.L1256F	BOD1L_uc010idr.1_Missense_Mutation_p.L593F	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	1256							DNA binding			ovary(5)|breast(1)	6						CTGTGTTTTTCAAATTCTTCT	0.393		NaN											0	0	0	1	0	6	58				
SEL1L3	23231	broad.mit.edu	37	4	25760599	25760599	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:25760599G>C	uc003gru.3	-	21	3199	c.3047C>G	c.(3046-3048)TCT>TGT	p.S1016C	SEL1L3_uc003grt.2_Missense_Mutation_p.S64C|SEL1L3_uc003grv.2_Missense_Mutation_p.S423C	NM_015187	NP_056002	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3	1016						integral to membrane	binding				0						GATGTTATTAGAATGGAGAGT	0.428		NaN											0	0	0	1	0	41	48				
RBPJ	3516	broad.mit.edu	37	4	26417162	26417162	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:26417162T>C	uc003grx.1	+	5	496	c.260T>C	c.(259-261)ATG>ACG	p.M87T	RBPJ_uc003gry.1_Missense_Mutation_p.M72T|RBPJ_uc003grz.1_Missense_Mutation_p.M87T|RBPJ_uc011bxt.1_Missense_Mutation_p.M87T|RBPJ_uc003gsa.1_Missense_Mutation_p.M73T|RBPJ_uc003gsb.1_Missense_Mutation_p.M74T|RBPJ_uc003gsc.1_Missense_Mutation_p.M73T	NM_005349	NP_005340	Q06330	SUH_HUMAN	recombining binding protein suppressor of	87					DNA recombination|negative regulation of transcription, DNA-dependent|positive regulation of transcription of Notch receptor target	cytoplasm|nucleolus|nucleoplasm	DNA binding|protein binding|recombinase activity|sequence-specific DNA binding transcription factor activity			ovary(1)|lung(1)|central_nervous_system(1)	3		Breast(46;0.0503)				AAAGAACAAATGGAACGCGAT	0.388		NaN											0	0	0	1	0	37	94				
PCDH7	5099	broad.mit.edu	37	4	30723251	30723251	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:30723251G>T	uc003gsk.1	+	1	1215	c.207G>T	c.(205-207)GAG>GAT	p.E69D	PCDH7_uc011bxw.1_Missense_Mutation_p.E69D|PCDH7_uc011bxx.1_Missense_Mutation_p.E69D	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	69	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						TCAGCCTGGAGTCCGGTTCCG	0.647		NaN											1	0	3.59834e-05	1	3.70396e-05	6	34				
PCDH7	5099	broad.mit.edu	37	4	30724469	30724469	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:30724469C>T	uc003gsk.1	+	1	2433	c.1425C>T	c.(1423-1425)GAC>GAT	p.D475D	PCDH7_uc011bxw.1_Silent_p.D428D|PCDH7_uc011bxx.1_Silent_p.D475D	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	475	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						CAGCCAGCGACACCGAGGGCG	0.627		NaN											0	0	0	1	0	8	31				
WDR19	57728	broad.mit.edu	37	4	39280196	39280196	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:39280196G>C	uc003gtv.2	+	36	4109	c.3955G>C	c.(3955-3957)GAA>CAA	p.E1319Q	WDR19_uc011byi.1_Missense_Mutation_p.E1159Q	NM_025132	NP_079408	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	1319					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						TATGTGTTCAGAAAGATTAAA	0.443		NaN											0	0	0	1	0	23	37				
TXK	7294	broad.mit.edu	37	4	48078437	48078437	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:48078437G>C	uc003gxx.3	-	12	1306	c.1220C>G	c.(1219-1221)TCA>TGA	p.S407*	TXK_uc010igj.2_RNA|TXK_uc011bzj.1_Nonsense_Mutation_p.S94*	NM_003328	NP_003319	P42681	TXK_HUMAN	TXK tyrosine kinase	407	Protein kinase.					cytoplasm	ATP binding|non-membrane spanning protein tyrosine kinase activity				0						TCCAAAGTCTGAAATTTTTAC	0.308		NaN											0	0	0	1	0	14	31				
TXK	7294	broad.mit.edu	37	4	48078458	48078458	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:48078458G>A	uc003gxx.3	-	12	1285	c.1199C>T	c.(1198-1200)TCA>TTA	p.S400L	TXK_uc010igj.2_RNA|TXK_uc011bzj.1_Missense_Mutation_p.S87L	NM_003328	NP_003319	P42681	TXK_HUMAN	TXK tyrosine kinase	400	Protein kinase.					cytoplasm	ATP binding|non-membrane spanning protein tyrosine kinase activity				0						TATGCATGTTGAACTGACCAA	0.323		NaN											0	0	0	1	0	16	38				
SLAIN2	57606	broad.mit.edu	37	4	48371957	48371957	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:48371957C>T	uc003gya.3	+	2	625	c.481C>T	c.(481-483)CCT>TCT	p.P161S		NM_020846	NP_065897	Q9P270	SLAI2_HUMAN	SLAIN motif family, member 2	161						centrosome					0						TTACCCAAGTCCTGATGTTGA	0.358		NaN											0	0	0	1	0	8	45				
PPAT	5471	broad.mit.edu	37	4	57272738	57272738	+	Missense_Mutation	SNP	C	C	T	rs141469911		TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:57272738C>T	uc003hbr.2	-	3	527	c.325G>A	c.(325-327)GTT>ATT	p.V109I		NM_002703	NP_002694	Q06203	PUR1_HUMAN	phosphoribosyl pyrophosphate amidotransferase	109	Glutamine amidotransferase type-2.				glutamine metabolic process|nucleoside metabolic process|purine base biosynthetic process|purine ribonucleoside monophosphate biosynthetic process	cytosol	4 iron, 4 sulfur cluster binding|amidophosphoribosyltransferase activity|metal ion binding				0	Glioma(25;0.08)|all_neural(26;0.101)				L-Glutamine(DB00130)|Thioguanine(DB00352)	GTTTCAACAACGAAGGGCTGA	0.378		NaN											0	0	0	1	0	22	50				
UBA6	55236	broad.mit.edu	37	4	68530981	68530981	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:68530981C>T	uc003hdg.3	-	10	875	c.823G>A	c.(823-825)GAC>AAC	p.D275N	UBA6_uc003hdi.2_Missense_Mutation_p.D275N|UBA6_uc003hdj.2_Missense_Mutation_p.D275N	NM_018227	NP_060697	A0AVT1	UBA6_HUMAN	ubiquitin-activating enzyme E1-like 2	275					protein ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|FAT10 activating enzyme activity|ligase activity|protein binding				0						TCTGTGGTGTCACCAATACTA	0.299		NaN											0	0	0	1	0	14	44				
YTHDC1	91746	broad.mit.edu	37	4	69202901	69202901	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:69202901C>G	uc003hdx.2	-	4	1080	c.727G>C	c.(727-729)GAG>CAG	p.E243Q	YTHDC1_uc003hdy.2_Missense_Mutation_p.E243Q	NM_001031732	NP_001026902	Q96MU7	YTDC1_HUMAN	splicing factor YT521-B isoform 1	243	Glu-rich.									upper_aerodigestive_tract(1)|ovary(1)	2						tcctcctcctcctcctcctct	0.184		NaN											0	0	0	1	0	7	31				
MOBKL1A	92597	broad.mit.edu	37	4	71824646	71824646	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:71824646C>T	uc003hfw.2	+	2	260	c.70C>T	c.(70-72)CAC>TAC	p.H24Y	MOBKL1A_uc003hfv.1_Missense_Mutation_p.H24Y|MOBKL1A_uc011cba.1_Missense_Mutation_p.H29Y	NM_173468	NP_775739	Q7L9L4	MOL1A_HUMAN	MOB1, Mps One Binder kinase activator-like 1A	24					hippo signaling cascade|protein autophosphorylation	cytoplasm|nucleus	kinase activator activity|kinase binding|metal ion binding				0		all_hematologic(202;0.21)	Lung(101;0.235)			AGAGGGTTCTCACCAGTATGA	0.413		NaN											0	0	0	1	0	59	24				
MOBKL1A	92597	broad.mit.edu	37	4	71824735	71824735	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:71824735C>T	uc003hfw.2	+	2	349	c.159C>T	c.(157-159)CTC>CTT	p.L53L	MOBKL1A_uc003hfv.1_Silent_p.L53L|MOBKL1A_uc011cba.1_Silent_p.L58L	NM_173468	NP_775739	Q7L9L4	MOL1A_HUMAN	MOB1, Mps One Binder kinase activator-like 1A	53					hippo signaling cascade|protein autophosphorylation	cytoplasm|nucleus	kinase activator activity|kinase binding|metal ion binding				0		all_hematologic(202;0.21)	Lung(101;0.235)			GGGAAGATCTCAATGAATGGG	0.468		NaN											0	0	0	1	0	29	22				
SEPT11	55752	broad.mit.edu	37	4	77952017	77952017	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:77952017G>T	uc003hkj.2	+	9	1330	c.1168G>T	c.(1168-1170)GAG>TAG	p.E390*	SEPT11_uc010ijh.1_Nonsense_Mutation_p.E382*|SEPT11_uc011cca.1_Nonsense_Mutation_p.E400*	NM_018243	NP_060713	Q9NVA2	SEP11_HUMAN	septin 11	390	Potential.				cell cycle|cell division|protein heterooligomerization	axon|cell junction|dendritic spine|septin complex|stress fiber|synapse	GTP binding|protein binding				0						GGAGCTTGAGGAGGAGGTGAA	0.468		NaN											1	0	7.48243e-07	1	7.82884e-07	10	37				
SCD5	79966	broad.mit.edu	37	4	83552481	83552481	+	Nonstop_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:83552481C>G	uc003hna.2	-	5	1312	c.992G>C	c.(991-993)TGA>TCA	p.*331S		NM_001037582	NP_001032671	Q86SK9	SCD5_HUMAN	stearoyl-CoA desaturase 5 isoform a	331					fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	iron ion binding|stearoyl-CoA 9-desaturase activity			ovary(1)	1		Colorectal(4;0.0323)|Hepatocellular(203;0.115)				GTTCCAAGTTCAAGCACTGCT	0.562		NaN											0	0	0	1	0	5	17				
COPS4	51138	broad.mit.edu	37	4	83984258	83984258	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:83984258C>G	uc003hoa.2	+	7	884	c.745C>G	c.(745-747)CTT>GTT	p.L249V	COPS4_uc003hob.2_Missense_Mutation_p.L249V|COPS4_uc010ijw.2_Missense_Mutation_p.L249V|COPS4_uc010ijx.2_Missense_Mutation_p.L249V	NM_016129	NP_057213	Q9BT78	CSN4_HUMAN	COP9 signalosome subunit 4	249	PCI.				cullin deneddylation	cytoplasm|signalosome	protein binding			kidney(1)	1		Hepatocellular(203;0.114)				GCTAGCTACTCTTTTTAAGGA	0.378		NaN											0	0	0	1	0	20	55				
PTPN13	5783	broad.mit.edu	37	4	87622564	87622564	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:87622564G>C	uc003hpz.2	+	7	1285	c.805G>C	c.(805-807)GAA>CAA	p.E269Q	PTPN13_uc003hpy.2_Missense_Mutation_p.E269Q|PTPN13_uc003hqa.2_Missense_Mutation_p.E269Q|PTPN13_uc003hqb.2_Missense_Mutation_p.E269Q	NM_080683	NP_542414	Q12923	PTN13_HUMAN	protein tyrosine phosphatase, non-receptor type	269						cytoplasm|cytoskeleton|plasma membrane	protein binding|protein binding|protein tyrosine phosphatase activity			ovary(4)|breast(1)|kidney(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.21)|Acute lymphoblastic leukemia(40;0.242)		OV - Ovarian serous cystadenocarcinoma(123;0.00082)		TGAAGATTCTGAAAATACATT	0.383		NaN											0	0	0	1	0	9	23				
SLC10A6	345274	broad.mit.edu	37	4	87749251	87749251	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:87749251G>C	uc003hqd.2	-	4	804	c.656C>G	c.(655-657)TCT>TGT	p.S219C		NM_197965	NP_932069	Q3KNW5	SOAT_HUMAN	sodium-dependent organic anion transporter	219	Extracellular (Potential).					integral to membrane|plasma membrane	bile acid:sodium symporter activity				0		Acute lymphoblastic leukemia(40;0.244)|all_hematologic(202;0.248)		OV - Ovarian serous cystadenocarcinoma(123;0.00099)		TGAATTCCAAGATCCTTTCGC	0.478		NaN											0	0	0	1	0	7	40				
HERC6	55008	broad.mit.edu	37	4	89363544	89363544	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:89363544G>C	uc011cdi.1	+	23	3184	c.3001G>C	c.(3001-3003)GAG>CAG	p.E1001Q	HERC6_uc011cdj.1_Missense_Mutation_p.E965Q|HERC6_uc011cdk.1_RNA|HERC6_uc011cdl.1_RNA	NM_017912	NP_060382	Q8IVU3	HERC6_HUMAN	hect domain and RLD 6 isoform 1	1001	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytosol	ubiquitin-protein ligase activity			lung(3)|ovary(1)|kidney(1)	5		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000222)		GGAAAGAATGGAGGAAGCACT	0.428		NaN											0	0	0	1	0	4	18				
FAM13A	10144	broad.mit.edu	37	4	89912254	89912254	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:89912254C>G	uc003hse.1	-	4	683	c.475G>C	c.(475-477)GAG>CAG	p.E159Q	FAM13A_uc003hsf.1_Intron|FAM13A_uc003hsh.1_5'UTR|FAM13A_uc003hsi.2_Missense_Mutation_p.E159Q|FAM13A_uc003hsj.2_Missense_Mutation_p.E159Q	NM_014883	NP_055698	O94988	FA13A_HUMAN	family with sequence similarity 13, member A1	159	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)|liver(1)	2						TCTGGCAGCTCTTTTATTAAG	0.383		NaN											0	0	0	1	0	6	20				
TBCK	93627	broad.mit.edu	37	4	107170104	107170104	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:107170104C>T	uc010ilv.2	-	8	1059	c.694G>A	c.(694-696)GAG>AAG	p.E232K	TBCK_uc003hyb.2_5'Flank|TBCK_uc003hye.2_Missense_Mutation_p.E193K|TBCK_uc003hyc.2_Missense_Mutation_p.E169K|TBCK_uc003hyd.2_Missense_Mutation_p.E60K|TBCK_uc003hyf.2_Missense_Mutation_p.E232K	NM_001163435	NP_001156907	Q8TEA7	TBCK_HUMAN	TBC domain-containing protein kinase-like	232	Protein kinase.					intracellular	Rab GTPase activator activity			large_intestine(2)|upper_aerodigestive_tract(1)|stomach(1)|ovary(1)	5						CAACCATGCTCTTCAGCCAGA	0.219		NaN											0	0	0	1	0	18	15				
SEC24B	10427	broad.mit.edu	37	4	110384480	110384480	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:110384480C>G	uc003hzk.2	+	2	612	c.557C>G	c.(556-558)TCA>TGA	p.S186*	SEC24B_uc003hzl.2_Nonsense_Mutation_p.S186*|SEC24B_uc011cfp.1_Nonsense_Mutation_p.S217*|SEC24B_uc011cfq.1_Nonsense_Mutation_p.S186*|SEC24B_uc011cfr.1_Nonsense_Mutation_p.S186*	NM_006323	NP_006314	O95487	SC24B_HUMAN	SEC24 (S. cerevisiae) homolog B isoform a	186					COPII vesicle coating|intracellular protein transport|post-translational protein modification|protein N-linked glycosylation via asparagine	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|Golgi membrane|perinuclear region of cytoplasm	protein binding|transporter activity|zinc ion binding			ovary(2)|large_intestine(1)	3		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;3.03e-05)		TATGCTATGTCAACTGTTTCT	0.453		NaN											0	0	0	1	0	44	144				
PRDM5	11107	broad.mit.edu	37	4	121828712	121828712	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:121828712C>A	uc003idn.2	-	2	344	c.94G>T	c.(94-96)GGT>TGT	p.G32C	PRDM5_uc003ido.2_Missense_Mutation_p.G32C|PRDM5_uc010ine.2_Missense_Mutation_p.G32C|PRDM5_uc010inf.2_Missense_Mutation_p.G32C|PRDM5_uc003idp.1_Missense_Mutation_p.G32C	NM_018699	NP_061169	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	32	SET.				histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2						AACTTTTCACCCTGAGTAGCA	0.358		NaN											1	0	5.35267e-07	1	5.62362e-07	20	26				
KIAA1109	84162	broad.mit.edu	37	4	123274148	123274148	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:123274148G>C	uc003ieh.2	+	79	13984	c.13939G>C	c.(13939-13941)GAA>CAA	p.E4647Q	KIAA1109_uc003iem.2_Missense_Mutation_p.E1003Q	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	4647					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TCCATTACCAGAAGATGGAAT	0.413		NaN											0	0	0	1	0	20	33				
SLC25A31	83447	broad.mit.edu	37	4	128665848	128665848	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:128665848G>T	uc003ifl.2	+	2	400	c.254G>T	c.(253-255)GGC>GTC	p.G85V		NM_031291	NP_112581	Q9H0C2	ADT4_HUMAN	solute carrier family 25 (mitochondrial carrier;	85	Solcar 1.				transmembrane transport	cilium|flagellum|integral to membrane|mitochondrial inner membrane	binding|transporter activity				0						TTTTGGCGTGGCAATTTGGCA	0.318		NaN											1	0	2.23348e-06	1	2.32731e-06	17	67				
RNF150	57484	broad.mit.edu	37	4	141832307	141832307	+	Missense_Mutation	SNP	T	T	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:141832307T>G	uc003iio.1	-	6	1843	c.1189A>C	c.(1189-1191)ACT>CCT	p.T397P	RNF150_uc010iok.1_Missense_Mutation_p.T355P|RNF150_uc003iip.1_Missense_Mutation_p.T397P	NM_020724	NP_065775	Q9ULK6	RN150_HUMAN	ring finger protein 150 precursor	397	Cytoplasmic (Potential).					integral to membrane	zinc ion binding			ovary(1)	1	all_hematologic(180;0.162)					CTGTTAGTAGTAAAGATGACG	0.463		NaN											0	0	0	1	0	5	33				
MORF4	10934	broad.mit.edu	37	4	174537200	174537200	+	Silent	SNP	A	A	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr4:174537200A>G	uc011cke.1	-	1	595	c.595T>C	c.(595-597)TTA>CTA	p.L199L		NM_006792	NP_006783			mortality factor 4												0		Prostate(90;0.00201)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0765)|all_hematologic(60;0.107)		all cancers(43;1.88e-18)|Epithelial(43;1.19e-16)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		TAATTGAGTAATAAAGCAAGG	0.428		NaN											0	0	0	1	0	22	30				
CTNND2	1501	broad.mit.edu	37	5	11411762	11411762	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:11411762C>A	uc003jfa.1	-	5	470	c.325G>T	c.(325-327)GGT>TGT	p.G109C	CTNND2_uc010itt.2_Missense_Mutation_p.G18C|CTNND2_uc011cmy.1_Missense_Mutation_p.G18C|CTNND2_uc011cmz.1_5'UTR|CTNND2_uc010itu.1_RNA	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	109					multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						TCTTTTTGACCATCTGAAATG	0.338		NaN											1	0	9.62906e-15	1	1.05753e-14	42	27				
MYO10	4651	broad.mit.edu	37	5	16769282	16769282	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:16769282C>G	uc003jft.3	-	10	1429	c.961G>C	c.(961-963)GAG>CAG	p.E321Q	MYO10_uc010itx.2_5'Flank	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	321	Myosin head-like.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						CGAACTTCCTCCTTGCTGAAC	0.418		NaN											0	0	0	1	0	7	34				
CDH6	1004	broad.mit.edu	37	5	31317550	31317550	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:31317550G>C	uc003jhe.1	+	10	1907	c.1581G>C	c.(1579-1581)TTG>TTC	p.L527F	CDH6_uc003jhd.1_Missense_Mutation_p.L527F	NM_004932	NP_004923	P55285	CADH6_HUMAN	cadherin 6, type 2 preproprotein	527	Extracellular (Potential).|Cadherin 5.				adherens junction organization|cell junction assembly|homophilic cell adhesion	cytoplasm|integral to membrane|nucleus|plasma membrane	calcium ion binding			ovary(4)|skin(2)|large_intestine(1)	7						CGTTTTCCTTGGCCCCTGAAG	0.413		NaN											0	0	0	1	0	29	114				
PDZD2	23037	broad.mit.edu	37	5	32074700	32074700	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:32074700C>T	uc003jhl.2	+	18	3876	c.3488C>T	c.(3487-3489)TCT>TTT	p.S1163F	PDZD2_uc003jhm.2_Missense_Mutation_p.S1163F|PDZD2_uc011cnx.1_Missense_Mutation_p.S989F	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	1163					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						CAGGCCACTTCTGTCAAAGTG	0.522		NaN											0	0	0	1	0	41	23				
NIPBL	25836	broad.mit.edu	37	5	37016225	37016225	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:37016225G>A	uc003jkl.3	+	23	5228	c.4729G>A	c.(4729-4731)GAA>AAA	p.E1577K	NIPBL_uc003jkk.3_Missense_Mutation_p.E1577K	NM_133433	NP_597677	Q6KC79	NIPBL_HUMAN	delangin isoform A	1577					brain development|cellular protein localization|cellular response to X-ray|cognition|developmental growth|ear morphogenesis|embryonic arm morphogenesis|embryonic digestive tract morphogenesis|external genitalia morphogenesis|eye morphogenesis|face morphogenesis|gall bladder development|maintenance of mitotic sister chromatid cohesion|metanephros development|negative regulation of transcription from RNA polymerase II promoter|outflow tract morphogenesis|positive regulation of histone deacetylation|regulation of developmental growth|regulation of embryonic development|regulation of hair cycle|response to DNA damage stimulus|sensory perception of sound|uterus morphogenesis	SMC loading complex	chromo shadow domain binding|histone deacetylase binding|protein C-terminus binding|protein N-terminus binding			ovary(4)|lung(2)|large_intestine(1)|breast(1)|kidney(1)	9	all_lung(31;0.000447)|Hepatocellular(1;0.108)		Epithelial(62;0.072)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.191)|Colorectal(62;0.202)			CAATAAGCCTGAATGGCCAGC	0.368		NaN											0	0	0	1	0	57	34				
EGFLAM	133584	broad.mit.edu	37	5	38407999	38407999	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:38407999G>C	uc003jlc.1	+	9	1564	c.1240G>C	c.(1240-1242)GAA>CAA	p.E414Q	EGFLAM_uc003jlb.1_Missense_Mutation_p.E414Q|EGFLAM_uc003jle.1_Missense_Mutation_p.E180Q|EGFLAM_uc003jlf.1_Intron	NM_152403	NP_689616	Q63HQ2	EGFLA_HUMAN	EGF-like, fibronectin type III and laminin G	414	Laminin G-like 1.					cell junction|proteinaceous extracellular matrix|synapse				pancreas(3)|skin(3)|ovary(1)	7	all_lung(31;0.000385)					AATTACTCTTGAATTTAGGGT	0.413		NaN											0	0	0	1	0	13	61				
HCN1	348980	broad.mit.edu	37	5	45396805	45396805	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:45396805G>A	uc003jok.2	-	4	1044	c.1019C>T	c.(1018-1020)TCT>TTT	p.S340F		NM_021072	NP_066550	O60741	HCN1_HUMAN	hyperpolarization activated cyclic	340	Extracellular (Potential).					integral to membrane	cAMP binding|sodium channel activity|voltage-gated potassium channel activity			ovary(1)	1						CTTTCCCCAAGAATCATTCTG	0.428		NaN											0	0	0	1	0	19	59				
DHX29	54505	broad.mit.edu	37	5	54581607	54581607	+	Silent	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:54581607C>G	uc003jpx.2	-	9	1269	c.1149G>C	c.(1147-1149)CTG>CTC	p.L383L	DHX29_uc010ivw.2_RNA	NM_019030	NP_061903	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	383							ATP binding|ATP-dependent helicase activity|translation initiation factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				CCCAATCAATCAGAAATTGTT	0.348		NaN											0	0	0	1	0	13	14				
GFM2	84340	broad.mit.edu	37	5	74035829	74035829	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:74035829C>G	uc003kdh.1	-	12	1368	c.1064G>C	c.(1063-1065)CGT>CCT	p.R355P	GFM2_uc003kdi.1_Missense_Mutation_p.R355P|GFM2_uc010izj.1_Missense_Mutation_p.R387P|GFM2_uc010izk.1_RNA|GFM2_uc003kdj.1_Missense_Mutation_p.R355P|GFM2_uc010izl.1_Missense_Mutation_p.R313P	NM_032380	NP_115756	Q969S9	RRF2M_HUMAN	mitochondrial elongation factor G2 isoform 1	355					mitochondrial translation|ribosome disassembly	mitochondrion	GTP binding|GTPase activity				0		all_lung(232;0.00101)|Lung NSC(167;0.00278)|Ovarian(174;0.0129)|Breast(144;0.231)		OV - Ovarian serous cystadenocarcinoma(47;1.86e-56)		TTCATAGTTACGCTCTTCAGG	0.363		NaN											0	0	0	1	0	17	1				
WDR41	55255	broad.mit.edu	37	5	76736794	76736794	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:76736794G>A	uc003kff.1	-	9	1013	c.726C>T	c.(724-726)GTC>GTT	p.V242V	WDR41_uc011csy.1_Silent_p.V184V|WDR41_uc011csz.1_Silent_p.V187V|WDR41_uc011cta.1_RNA|WDR41_uc011ctb.1_RNA	NM_018268	NP_060738	Q9HAD4	WDR41_HUMAN	WD repeat domain 41	242	WD 4.										0		all_lung(232;0.000961)|Lung NSC(167;0.0011)|Ovarian(174;0.0105)|Prostate(461;0.059)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-50)|Epithelial(54;2.04e-44)|all cancers(79;6.84e-40)		TCAGCTCTCCGACGTGGGAGC	0.453		NaN											0	0	0	1	0	11	27				
SERINC5	256987	broad.mit.edu	37	5	79473155	79473155	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:79473155G>C	uc003kgj.2	-	4	568	c.439C>G	c.(439-441)CAG>GAG	p.Q147E	SERINC5_uc003kgk.2_Missense_Mutation_p.Q147E|SERINC5_uc003kgl.2_RNA|SERINC5_uc003kgm.2_Missense_Mutation_p.Q147E|SERINC5_uc011ctj.1_Missense_Mutation_p.Q147E	NM_178276	NP_840060	Q86VE9	SERC5_HUMAN	developmentally regulated protein TPO1	147	Cytoplasmic (Potential).				phosphatidylserine metabolic process|phospholipid biosynthetic process|positive regulation of transferase activity	endoplasmic reticulum membrane|integral to membrane				ovary(1)	1		Lung NSC(167;0.00328)|all_lung(232;0.00356)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;2.93e-46)|Epithelial(54;5.59e-40)|all cancers(79;1.89e-34)		AAGGTGTCCTGATCTGGAATG	0.413		NaN											0	0	0	1	0	29	4				
TTC37	9652	broad.mit.edu	37	5	94834293	94834293	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:94834293G>C	uc003klb.2	-	33	3614	c.3344C>G	c.(3343-3345)TCT>TGT	p.S1115C		NM_014639	NP_055454	Q6PGP7	TTC37_HUMAN	tetratricopeptide repeat domain 37	1115							binding			ovary(3)|pancreas(1)	4						CTTTAAGATAGAGCTGTAAAG	0.279		NaN											0	0	0	1	0	11	15				
GLRX	2745	broad.mit.edu	37	5	95158310	95158310	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:95158310G>C	uc003klo.3	-	1	268	c.57C>G	c.(55-57)ATC>ATG	p.I19M	GLRX_uc003kln.3_Missense_Mutation_p.I19M	NM_001118890	NP_001112362	P35754	GLRX1_HUMAN	glutaredoxin (thioltransferase)	19	Glutaredoxin.				cell redox homeostasis|electron transport chain|nucleobase, nucleoside and nucleotide interconversion|transport	cytosol	electron carrier activity|glutathione disulfide oxidoreductase activity|protein disulfide oxidoreductase activity|protein N-terminus binding				0		all_cancers(142;3.38e-06)|all_epithelial(76;5.66e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.0164)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;2.62e-16)	Glutathione(DB00143)	AGGTGGGCTTGATGAACACAA	0.547		NaN											0	0	0	1	0	19	29				
ERAP2	64167	broad.mit.edu	37	5	96219518	96219518	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:96219518G>C	uc003kmq.2	+	3	1308	c.598G>C	c.(598-600)GAG>CAG	p.E200Q	uc003kmo.1_Intron|ERAP2_uc003kmt.2_Missense_Mutation_p.E200Q|ERAP2_uc003kmr.2_RNA|ERAP2_uc003kms.2_Missense_Mutation_p.E194Q|ERAP2_uc003kmu.2_RNA	NM_022350	NP_071745	Q6P179	ERAP2_HUMAN	endoplasmic reticulum aminopeptidase 2	200	Lumenal (Potential).	Substrate (By similarity).			antigen processing and presentation of endogenous peptide antigen via MHC class I|proteolysis|regulation of blood pressure	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding				0		all_cancers(142;0.000311)|all_epithelial(76;1.54e-06)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0596)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0703)		AACAGATTTTGAGCCAACCCA	0.433		NaN											0	0	0	1	0	15	18				
ERAP2	64167	broad.mit.edu	37	5	96249154	96249154	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:96249154C>T	uc003kmq.2	+	17	3360	c.2650C>T	c.(2650-2652)CTG>TTG	p.L884L	uc003kmo.1_Intron|ERAP2_uc003kmt.2_Silent_p.L884L|ERAP2_uc003kmr.2_RNA|ERAP2_uc003kms.2_Silent_p.L833L|ERAP2_uc003kmu.2_RNA	NM_022350	NP_071745	Q6P179	ERAP2_HUMAN	endoplasmic reticulum aminopeptidase 2	884	Lumenal (Potential).				antigen processing and presentation of endogenous peptide antigen via MHC class I|proteolysis|regulation of blood pressure	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding				0		all_cancers(142;0.000311)|all_epithelial(76;1.54e-06)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0596)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0703)		GACCCATCTTCTGAAAAAGTT	0.413		NaN											0	0	0	1	0	7	15				
RIOK2	55781	broad.mit.edu	37	5	96503580	96503580	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:96503580C>G	uc003kmz.2	-	8	1098	c.988G>C	c.(988-990)GAG>CAG	p.E330Q	RIOK2_uc003kna.3_Missense_Mutation_p.E330Q	NM_018343	NP_060813	Q9BVS4	RIOK2_HUMAN	RIO kinase 2 isoform 1	330	Protein kinase.						ATP binding|protein serine/threonine kinase activity			kidney(1)	1		all_cancers(142;0.000125)|all_epithelial(76;8.48e-07)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0676)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0657)		TCAGATCCCTCTTTTGTTTCA	0.408		NaN											0	0	0	1	0	52	69				
REEP5	7905	broad.mit.edu	37	5	112238167	112238167	+	Silent	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:112238167C>G	uc003kqe.1	-	3	405	c.261G>C	c.(259-261)CTG>CTC	p.L87L	REEP5_uc011cvw.1_Silent_p.L60L|REEP5_uc011cvx.1_RNA|REEP5_uc011cvy.1_Silent_p.L87L|REEP5_uc011cvz.1_Intron	NM_005669	NP_005660	Q00765	REEP5_HUMAN	receptor accessory protein 5	87						integral to membrane	protein binding				0		all_cancers(142;4.41e-05)|all_epithelial(76;3.65e-07)|Colorectal(10;0.00115)|Prostate(80;0.00133)|Ovarian(225;0.0443)		Epithelial(69;1.3e-09)|OV - Ovarian serous cystadenocarcinoma(64;1.26e-08)|all cancers(49;3.56e-07)|Colorectal(14;0.00778)|COAD - Colon adenocarcinoma(37;0.013)		CCCAGTAGGTCAGCCACTGGG	0.398		NaN											0	0	0	1	0	13	28				
LOX	4015	broad.mit.edu	37	5	121413262	121413262	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:121413262G>A	uc003ksu.2	-	1	794	c.419C>T	c.(418-420)TCG>TTG	p.S140L	LOX_uc010jcq.2_5'Flank|LOX_uc011cwk.1_5'Flank|LOX_uc010jcr.2_5'Flank	NM_002317	NP_002308	P28300	LYOX_HUMAN	lysyl oxidase preproprotein	140					protein modification process	extracellular space	copper ion binding|protein-lysine 6-oxidase activity			lung(1)	1		all_cancers(142;0.0124)|Prostate(80;0.0322)|Ovarian(225;0.0814)|Breast(839;0.143)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	Epithelial(69;2.14e-11)|OV - Ovarian serous cystadenocarcinoma(64;7.87e-10)|all cancers(49;2.49e-09)|COAD - Colon adenocarcinoma(49;0.02)		CTCCGCGCGCGAGGCGCCAGC	0.692		NaN											0	0	0	1	0	14	3				
PRRC1	133619	broad.mit.edu	37	5	126862374	126862374	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:126862374C>T	uc003kuk.2	+	4	738	c.558C>T	c.(556-558)ACC>ACT	p.T186T	PRRC1_uc003kuj.3_Silent_p.T186T	NM_130809	NP_570721	Q96M27	PRRC1_HUMAN	proline-rich coiled-coil 1	186						Golgi apparatus					0		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0851)|Epithelial(69;0.113)		GAACTGGAACCACATCAGCCA	0.413		NaN											0	0	0	1	0	16	17				
EGR1	1958	broad.mit.edu	37	5	137801586	137801586	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:137801586C>A	uc003ldb.1	+	1	406	c.136C>A	c.(136-138)CCC>ACC	p.P46T	EGR1_uc011cyu.1_Missense_Mutation_p.P46T	NM_001964	NP_001955	P18146	EGR1_HUMAN	early growth response 1	46					cellular response to heparin|cellular response to mycophenolic acid|glomerular mesangial cell proliferation|interleukin-1-mediated signaling pathway|positive regulation of glomerular metanephric mesangial cell proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of protein sumoylation|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytoplasm|nucleus	histone acetyltransferase binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			CAACGGGGCTCCCCAGTTCCT	0.433		NaN											1	0	2.40579e-17	1	2.66234e-17	37	2				
PCDHB1	29930	broad.mit.edu	37	5	140432144	140432144	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:140432144G>C	uc003lik.1	+	1	1166	c.1089G>C	c.(1087-1089)CAG>CAC	p.Q363H		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	363	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CACCACCACAGACAGTAGTAG	0.502		NaN											0	0	0	1	0	19	31				
PCDHB2	56133	broad.mit.edu	37	5	140476693	140476693	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:140476693C>T	uc003lil.2	+	1	2457	c.2319C>T	c.(2317-2319)ATC>ATT	p.I773I	PCDHB2_uc003lim.1_Silent_p.I434I	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	773	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGCCAATTATCCCCAACTTCG	0.512		NaN											0	0	0	1	0	40	10				
PCDHB5	26167	broad.mit.edu	37	5	140516663	140516663	+	Silent	SNP	G	G	A	rs149096993		TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:140516663G>A	uc003liq.2	+	1	1864	c.1647G>A	c.(1645-1647)CTG>CTA	p.L549L		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	549	Extracellular (Potential).|Cadherin 5.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGCGCGTGCTGGTGCTGGACG	0.721		NaN											0	0	0	1	0	21	37				
PCDHGA7	56108	broad.mit.edu	37	5	140763490	140763490	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:140763490G>A	uc003lka.1	+	1	1024	c.1024G>A	c.(1024-1026)GAT>AAT	p.D342N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Missense_Mutation_p.D342N	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	342	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGATGTAAATGATAATGCTCC	0.413		NaN											0	0	0	1	0	38	5				
PCDHGA7	56108	broad.mit.edu	37	5	140763541	140763541	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:140763541G>A	uc003lka.1	+	1	1075	c.1075G>A	c.(1075-1077)GAC>AAC	p.D359N	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Missense_Mutation_p.D359N	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	359	Cadherin 4.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AATCCCTGAAGACACACCTCT	0.418		NaN											0	0	0	1	0	26	4				
SPINK5	11005	broad.mit.edu	37	5	147449904	147449904	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:147449904C>T	uc003lox.2	+	3	173	c.100C>T	c.(100-102)CAG>TAG	p.Q34*	SPINK5_uc010jgq.1_RNA|SPINK5_uc010jgs.1_Nonsense_Mutation_p.Q6*|SPINK5_uc010jgr.2_Intron|SPINK5_uc003low.2_Nonsense_Mutation_p.Q34*|SPINK5_uc003loy.2_Nonsense_Mutation_p.Q34*	NM_006846	NP_006837	Q9NQ38	ISK5_HUMAN	serine peptidase inhibitor, Kazal type 5 isoform	34	Kazal-like 1; atypical.				anagen|epithelial cell differentiation|extracellular matrix organization|hair cell differentiation|negative regulation of angiogenesis|negative regulation of immune response|regulation of T cell differentiation	cell cortex|cytosol|endoplasmic reticulum membrane|extracellular region|lamellar body|perinuclear region of cytoplasm	serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)|breast(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCATGAATTTCAGGCATTTAT	0.289		NaN											0	0	0	1	0	29	4				
IL17B	27190	broad.mit.edu	37	5	148754083	148754083	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:148754083G>A	uc003lqo.2	-	3	442	c.392C>T	c.(391-393)ACC>ATC	p.T131I		NM_014443	NP_055258	Q9UHF5	IL17B_HUMAN	interleukin 17B precursor	131					cell-cell signaling|immune response|inflammatory response	extracellular space	cytokine activity|signal transducer activity			central_nervous_system(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTCCTGCATGGTGAAGGGGTT	0.682		NaN											0	0	0	1	0	18	17				
SLC36A3	285641	broad.mit.edu	37	5	150660605	150660605	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:150660605A>G	uc003ltw.2	-	9	1533	c.1114T>C	c.(1114-1116)TCT>CCT	p.S372P	GM2A_uc011dcs.1_Intron|SLC36A3_uc003ltv.2_Missense_Mutation_p.S357P|SLC36A3_uc003ltx.2_Missense_Mutation_p.S413P	NM_181774	NP_861439	Q495N2	S36A3_HUMAN	solute carrier family 36, member 3 isoform 2	372	Helical; (Potential).					integral to membrane				ovary(2)|skin(1)	3		Medulloblastoma(196;0.109)|all_hematologic(541;0.243)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GAGCGGACAGACAGGTCTACA	0.552		NaN											0	0	0	1	0	19	23				
GEMIN5	25929	broad.mit.edu	37	5	154268890	154268890	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:154268890C>G	uc003lvx.3	-	27	4433	c.4350G>C	c.(4348-4350)GAG>GAC	p.E1450D	GEMIN5_uc011ddk.1_Missense_Mutation_p.E1449D	NM_015465	NP_056280	Q8TEQ6	GEMI5_HUMAN	gemin 5	1450					ncRNA metabolic process|protein complex assembly|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding|snRNA binding			skin(2)|ovary(1)	3	Renal(175;0.00488)	Medulloblastoma(196;0.0354)|all_neural(177;0.147)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CCTTAATGCTCTCAGGAAATT	0.368		NaN											0	0	0	1	0	13	16				
ITK	3702	broad.mit.edu	37	5	156659373	156659373	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:156659373G>A	uc003lwo.1	+	8	819	c.737G>A	c.(736-738)CGA>CAA	p.R246Q		NM_005546	NP_005537	Q08881	ITK_HUMAN	IL2-inducible T-cell kinase	246	SH2.				cellular defense response|intracellular signal transduction|T cell receptor signaling pathway	cytosol|plasma membrane	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding			lung(12)|ovary(8)|skin(4)|stomach(1)|central_nervous_system(1)	26	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.1)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			AGTATCAGCCGAGACAAAGCT	0.269		NaN	T	SYK	peripheral T-cell lymphoma								0	0	0	1	0	16	1				
STK10	6793	broad.mit.edu	37	5	171544538	171544538	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:171544538C>T	uc003mbo.1	-	4	767	c.467G>A	c.(466-468)CGA>CAA	p.R156Q		NM_005990	NP_005981	O94804	STK10_HUMAN	serine/threonine kinase 10	156	Protein kinase.						ATP binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|testis(1)|breast(1)|pancreas(1)	8	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			TTTCAGATCTCGGTGGATGAT	0.597		NaN											0	0	0	1	0	16	19				
UNC5A	90249	broad.mit.edu	37	5	176304229	176304229	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:176304229G>T	uc003mey.2	+	9	1607	c.1415G>T	c.(1414-1416)CGA>CTA	p.R472L		NM_133369	NP_588610	Q6ZN44	UNC5A_HUMAN	netrin receptor Unc5h1 precursor	472	ZU5.|Cytoplasmic (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				skin(1)	1	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GCCATACCCCGAGGGAAGATC	0.637		NaN											1	0	7.26314e-15	1	7.98553e-15	29	2				
MAPK9	5601	broad.mit.edu	37	5	179707519	179707519	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr5:179707519C>G	uc003mls.3	-	2	314	c.43G>C	c.(43-45)GTG>CTG	p.V15L	MAPK9_uc003mlt.3_Missense_Mutation_p.V15L|MAPK9_uc010jlc.2_Missense_Mutation_p.V15L|MAPK9_uc003mlv.3_Missense_Mutation_p.V15L|MAPK9_uc011dgx.1_Missense_Mutation_p.V15L	NM_002752	NP_002743	P45984	MK09_HUMAN	mitogen-activated protein kinase 9 isoform JNK2	15					innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|protein binding|protein binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)	4	all_cancers(89;6.54e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0236)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GAGTCTGCCACTTGCACACTA	0.458		NaN											0	0	0	1	0	8	43				
ACOT13	55856	broad.mit.edu	37	6	24667557	24667557	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:24667557G>C	uc003nek.2	+	1	295	c.66G>C	c.(64-66)GAG>GAC	p.E22D	TDP2_uc003nei.2_5'Flank|TDP2_uc003nej.2_5'Flank|TDP2_uc010jpu.1_5'Flank|ACOT13_uc010jpv.2_5'UTR	NM_018473	NP_060943	Q9NPJ3	ACO13_HUMAN	acyl-CoA thioesterase 13 isoform 1	22					protein homotetramerization	mitochondrion	acyl-CoA thioesterase activity				0						GCAATTTTGAGAGAGTTTTGG	0.502		NaN									OREG0017230	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	13	29				
FAM65B	9750	broad.mit.edu	37	6	24843425	24843425	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:24843425C>G	uc003neo.1	-	14	1761	c.1585G>C	c.(1585-1587)GAG>CAG	p.E529Q	FAM65B_uc011djs.1_Missense_Mutation_p.E508Q|FAM65B_uc011dju.1_Missense_Mutation_p.E513Q|FAM65B_uc003nep.2_Missense_Mutation_p.E479Q|FAM65B_uc011djt.1_Missense_Mutation_p.E479Q	NM_014722	NP_055537	Q9Y4F9	FA65B_HUMAN	hypothetical protein LOC9750 isoform 1	529					cell differentiation|muscle organ development	cytoskeleton|filopodium|mitochondrion	binding			ovary(1)	1						AACAGGTGCTCAGCCCCAGCA	0.572		NaN											0	0	0	1	0	18	68				
LRRC16A	55604	broad.mit.edu	37	6	25581557	25581557	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:25581557C>T	uc011djw.1	+	31	3272	c.2896C>T	c.(2896-2898)CGG>TGG	p.R966W	LRRC16A_uc010jpx.2_Missense_Mutation_p.R966W|LRRC16A_uc010jpy.2_Missense_Mutation_p.R966W	NM_017640	NP_060110	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	966	LRR 11.|Inhibits capping activity of CAPZA2 (By similarity).				actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				ovary(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4						ACAGGAGAAGCGGAGCTCGGG	0.463		NaN											0	0	0	1	0	15	5				
DHX16	8449	broad.mit.edu	37	6	30624524	30624524	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:30624524G>C	uc003nqz.2	-	14	2373	c.2161C>G	c.(2161-2163)CAG>GAG	p.Q721E	DHX16_uc003nqy.2_Missense_Mutation_p.Q240E|DHX16_uc011dmo.1_Missense_Mutation_p.Q661E	NM_003587	NP_003578	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	721	Helicase C-terminal.				mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			ovary(2)|kidney(2)	4						CCAGCTCGCTGATTGGCTGAG	0.542		NaN											0	0	0	1	0	18	50				
HLA-C	3107	broad.mit.edu	37	6	31237268	31237268	+	Splice_Site	SNP	A	A	C	rs111308207		TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:31237268A>C	uc003nsy.2	-	6	1055	c.1048_splice	c.e6+1	p.C350_splice	HLA-C_uc011dnj.1_Splice_Site_p.C322_splice|HLA-C_uc003nsx.2_Splice_Site_p.C229_splice|HLA-C_uc003nsz.2_Splice_Site_p.C356_splice|HLA-C_uc010jsl.2_Intron|HLA-C_uc003nta.2_Splice_Site_p.S350_splice|HLA-C_uc003ntb.2_Splice_Site|HLA-C_uc003ntc.1_Intron|HLA-B_uc010jsm.1_Splice_Site	NM_002117	NP_002108	Q9TNN7	1C05_HUMAN	major histocompatibility complex, class I, C						antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex					0						GCCATCACTTACACGCAGCCT	0.557		NaN											0	0	0	1	0	5	14				
TEAD3	7005	broad.mit.edu	37	6	35443426	35443426	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:35443426G>A	uc003oku.3	-	11	1194	c.958C>T	c.(958-960)CAG>TAG	p.Q320*	TEAD3_uc003okt.2_Nonsense_Mutation_p.Q209*|TEAD3_uc010jvx.2_Nonsense_Mutation_p.Q260*	NM_003214	NP_003205	Q99594	TEAD3_HUMAN	TEA domain family member 3	320	Transcriptional activation (Potential).				female pregnancy|hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GAGCTGTACTGAGAGCTGACC	0.612		NaN											0	0	0	1	0	18	39				
TULP1	7287	broad.mit.edu	37	6	35478728	35478728	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:35478728C>G	uc003okv.3	-	5	421	c.409G>C	c.(409-411)GAG>CAG	p.E137Q	TULP1_uc003okw.3_Missense_Mutation_p.E84Q	NM_003322	NP_003313	O00294	TULP1_HUMAN	tubby like protein 1	137					dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding			ovary(2)|central_nervous_system(1)	3						AGGATTTTctctttcttttcc	0.408		NaN											0	0	0	1	0	19	31				
LHFPL5	222662	broad.mit.edu	37	6	35773514	35773514	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:35773514C>T	uc003olg.1	+	1	444	c.67C>T	c.(67-69)CGA>TGA	p.R23*		NM_182548	NP_872354	Q8TAF8	TMHS_HUMAN	lipoma HMGIC fusion partner-like 5	23						integral to membrane				skin(1)	1						GCGGAACTCGCGAGCCGTGGG	0.617		NaN											0	0	0	1	0	24	59				
BTBD9	114781	broad.mit.edu	37	6	38561774	38561774	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:38561774A>G	uc003ooa.3	-	4	1091	c.515T>C	c.(514-516)GTC>GCC	p.V172A	BTBD9_uc003ony.3_Missense_Mutation_p.V104A|BTBD9_uc010jwv.2_Missense_Mutation_p.V104A|BTBD9_uc010jww.2_RNA|BTBD9_uc010jwx.2_Missense_Mutation_p.V172A	NM_052893	NP_443125	Q96Q07	BTBD9_HUMAN	BTB (POZ) domain containing 9 isoform a	172	BACK.				cell adhesion						0						ACTTGAGAGGACTTCCTGAGC	0.383		NaN											0	0	0	1	0	48	137				
GLO1	2739	broad.mit.edu	37	6	38670780	38670780	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:38670780G>A	uc003ooc.2	-	1	173	c.51C>T	c.(49-51)CTC>CTT	p.L17L		NM_006708	NP_006699	Q04760	LGUL_HUMAN	glyoxalase I	17					anti-apoptosis|carbohydrate metabolic process	cytoplasm	lactoylglutathione lyase activity|metal ion binding			ovary(1)	1					Glutathione(DB00143)	AGCAGCAACTGAGGGCGGCCT	0.692		NaN											0	0	0	1	0	10	1				
ZNF318	24149	broad.mit.edu	37	6	43322436	43322436	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:43322436G>C	uc003oux.2	-	4	2714	c.2636C>G	c.(2635-2637)TCT>TGT	p.S879C	ZNF318_uc003ouw.2_RNA	NM_014345	NP_055160	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	879	Potential.				meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(3)|breast(2)|central_nervous_system(1)|skin(1)	7			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			CTTCTCATCAGAGATCTTCTC	0.438		NaN											0	0	0	1	0	67	5				
NFKBIE	4794	broad.mit.edu	37	6	44232769	44232769	+	Silent	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:44232769C>G	uc003oxe.1	-	1	757	c.732G>C	c.(730-732)CTG>CTC	p.L244L		NM_004556	NP_004547	O00221	IKBE_HUMAN	nuclear factor of kappa light polypeptide gene	244					cytoplasmic sequestering of transcription factor		protein binding			breast(2)	2	all_cancers(18;2e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			GCTGAGGGCTCAGCGCCCCCA	0.662		NaN											0	0	0	1	0	3	2				
C6orf138	442213	broad.mit.edu	37	6	47847059	47847059	+	Silent	SNP	A	A	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:47847059A>C	uc011dwm.1	-	3	1555	c.1470T>G	c.(1468-1470)GTT>GTG	p.V490V	C6orf138_uc011dwn.1_Silent_p.V254V	NM_001013732	NP_001013754	Q6ZW05	CF138_HUMAN	hypothetical protein LOC442213	507						integral to membrane	hedgehog receptor activity			central_nervous_system(1)	1						ATTTCTGCTGAACCATGGCAT	0.478		NaN											0	0	0	1	0	9	3				
TFAP2D	83741	broad.mit.edu	37	6	50740451	50740451	+	Silent	SNP	A	A	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:50740451A>G	uc003paf.2	+	8	1745	c.1233A>G	c.(1231-1233)AAA>AAG	p.K411K	TFAP2D_uc011dwt.1_RNA	NM_172238	NP_758438	Q7Z6R9	AP2D_HUMAN	transcription factor AP-2 beta-like 1	411							DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|breast(1)	7	Lung NSC(77;0.0334)					ACTTGGAAAAACACACTACTC	0.502		NaN											0	0	0	1	0	16	28				
GSTA2	2939	broad.mit.edu	37	6	52615459	52615459	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:52615459C>G	uc003pay.2	-	7	735	c.585G>C	c.(583-585)AAG>AAC	p.K195N		NM_000846	NP_000837	P09210	GSTA2_HUMAN	glutathione S-transferase alpha 2	195	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)	1	Lung NSC(77;0.118)				Aminophenazone(DB01424)|Amsacrine(DB00276)|Busulfan(DB01008)|Chlorambucil(DB00291)|Chloroquine(DB00608)|Cinnarizine(DB00568)|Clofibrate(DB00636)|Ethacrynic acid(DB00903)|Glutathione(DB00143)|Mechlorethamine(DB00888)|Praziquantel(DB01058)|Vitamin E(DB00163)	GTAGAAACTTCTTCACTGTGG	0.453		NaN											0	0	0	1	0	54	38				
BAI3	577	broad.mit.edu	37	6	69949067	69949067	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:69949067C>T	uc003pev.3	+	20	3211	c.2763C>T	c.(2761-2763)ATC>ATT	p.I921I	BAI3_uc010kak.2_Silent_p.I921I|BAI3_uc011dxx.1_Silent_p.I127I|BAI3_uc003pex.1_Silent_p.I51I	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	921	Helical; Name=2; (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				GCCTGTCTATCATCTCATCCA	0.353		NaN											0	0	0	1	0	37	44				
COL9A1	1297	broad.mit.edu	37	6	70964891	70964891	+	Silent	SNP	T	T	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:70964891T>G	uc003pfg.3	-	23	1732	c.1573A>C	c.(1573-1575)AGA>CGA	p.R525R	COL9A1_uc003pfe.3_Silent_p.R98R|COL9A1_uc003pff.3_Silent_p.R282R	NM_001851	NP_001842	P20849	CO9A1_HUMAN	alpha 1 type IX collagen isoform 1 precursor	525	Triple-helical region (COL2).				axon guidance|cell adhesion|organ morphogenesis	collagen type IX	metal ion binding			ovary(4)	4						GGAATTCCTCTAGCACCTTCA	0.443		NaN											0	0	0	1	0	37	55				
BEND3	57673	broad.mit.edu	37	6	107391788	107391788	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:107391788G>C	uc003prs.2	-	5	1257	c.607C>G	c.(607-609)CTG>GTG	p.L203V		NM_001080450	NP_001073919	Q5T5X7	BEND3_HUMAN	BEN domain containing 3	203										ovary(3)	3						AGGGTGTTCAGCATGTAGAAC	0.572		NaN											0	0	0	1	0	4	27				
MICAL1	64780	broad.mit.edu	37	6	109766413	109766413	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:109766413C>T	uc003ptj.2	-	21	3122	c.2868G>A	c.(2866-2868)TTG>TTA	p.L956L	MICAL1_uc003ptk.2_Silent_p.L956L|MICAL1_uc010kdr.2_Silent_p.L870L|MICAL1_uc011eaq.1_Silent_p.L975L	NM_022765	NP_073602	Q8TDZ2	MICA1_HUMAN	microtubule associated monoxygenase, calponin	956	Potential.				cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			breast(2)|ovary(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		TCTGGCGCCTCAAGGCCAGCT	0.592		NaN											0	0	0	1	0	16	19				
REV3L	5980	broad.mit.edu	37	6	111697217	111697217	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:111697217C>T	uc003puy.3	-	13	2664	c.2341G>A	c.(2341-2343)GAA>AAA	p.E781K	REV3L_uc003pux.3_Missense_Mutation_p.E703K|REV3L_uc003puz.3_Missense_Mutation_p.E703K	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	781					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		GTTTTATGTTCTTGAAATTCT	0.378		NaN						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	1	0	23	33				
C6orf225	619208	broad.mit.edu	37	6	112420507	112420507	+	Silent	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:112420507C>A	uc003pvs.2	+	3	446	c.21C>A	c.(19-21)ACC>ACA	p.T7T		NM_001033564	NP_001028736	Q4G0N7	CF225_HUMAN	hypothetical protein LOC619208	7											0						AATTTGGAACCCAGCCAAGGA	0.428		NaN											1	0	2.70639e-06	1	2.8172e-06	21	31				
STX7	8417	broad.mit.edu	37	6	132785148	132785148	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:132785148C>T	uc003qdg.2	-	9	927	c.677G>A	c.(676-678)AGG>AAG	p.R226K	STX7_uc011ecg.1_RNA|STX7_uc011ech.1_Missense_Mutation_p.R51K	NM_003569	NP_003560	O15400	STX7_HUMAN	syntaxin 7	226	t-SNARE coiled-coil homology.|Cytoplasmic (Potential).				intracellular protein transport|post-Golgi vesicle-mediated transport	early endosome membrane|integral to membrane	SNAP receptor activity				0	Breast(56;0.0615)			OV - Ovarian serous cystadenocarcinoma(155;0.00532)|GBM - Glioblastoma multiforme(226;0.0114)		ATCTGCTGCCCTTGACAGCTG	0.393		NaN											0	0	0	1	0	28	35				
TAAR5	9038	broad.mit.edu	37	6	132910508	132910508	+	Silent	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:132910508G>C	uc003qdk.2	-	1	370	c.318C>G	c.(316-318)CTC>CTG	p.L106L		NM_003967	NP_003958	O14804	TAAR5_HUMAN	trace amine associated receptor 5	106	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity			skin(1)	1	Breast(56;0.112)			OV - Ovarian serous cystadenocarcinoma(155;0.00604)|GBM - Glioblastoma multiforme(226;0.015)		GCAGGCGGCAGAGGAAGTCCC	0.592		NaN											0	0	0	1	0	30	31				
GRM1	2911	broad.mit.edu	37	6	146350756	146350756	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:146350756C>T	uc010khw.1	+	2	573	c.103C>T	c.(103-105)CAG>TAG	p.Q35*	GRM1_uc010khu.1_Nonsense_Mutation_p.Q35*|GRM1_uc010khv.1_Nonsense_Mutation_p.Q35*|GRM1_uc003qll.2_Nonsense_Mutation_p.Q35*|GRM1_uc011edz.1_Nonsense_Mutation_p.Q35*|GRM1_uc011eea.1_Nonsense_Mutation_p.Q35*	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	35	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	AGCGTCGTCTCAGCGCTCGGT	0.582		NaN											0	0	0	1	0	44	81				
SYNE1	23345	broad.mit.edu	37	6	152583209	152583209	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:152583209C>G	uc010kiw.2	-	101	19532	c.18930G>C	c.(18928-18930)CAG>CAC	p.Q6310H	SYNE1_uc010kiv.2_Missense_Mutation_p.Q834H|SYNE1_uc003qos.3_Missense_Mutation_p.Q834H|SYNE1_uc003qot.3_Missense_Mutation_p.Q6239H|SYNE1_uc003qou.3_Missense_Mutation_p.Q6310H	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6310	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GTAGTAGTTTCTGCTTGGTAC	0.368		NaN								HNSCC(10;0.0054)			0	0	0	1	0	15	28				
SYNE1	23345	broad.mit.edu	37	6	152599392	152599392	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:152599392C>G	uc010kiw.2	-	98	19007	c.18405G>C	c.(18403-18405)CAG>CAC	p.Q6135H	SYNE1_uc010kiv.2_Missense_Mutation_p.Q659H|SYNE1_uc003qos.3_Missense_Mutation_p.Q659H|SYNE1_uc003qot.3_Missense_Mutation_p.Q6064H|SYNE1_uc003qou.3_Missense_Mutation_p.Q6135H|SYNE1_uc010kiy.1_Missense_Mutation_p.Q314H	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	6135	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCACCACCTTCTGCTCTATTT	0.498		NaN								HNSCC(10;0.0054)			0	0	0	1	0	6	95				
TAGAP	117289	broad.mit.edu	37	6	159457377	159457377	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:159457377C>G	uc003qrz.2	-	10	2010	c.1678G>C	c.(1678-1680)GAA>CAA	p.E560Q	TAGAP_uc011eft.1_Missense_Mutation_p.E497Q|TAGAP_uc003qsa.2_Missense_Mutation_p.E382Q	NM_054114	NP_473455	Q8N103	TAGAP_HUMAN	T-cell activation Rho GTPase-activating protein	560					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-16)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		TTGTGGGTTTCACACCCATTT	0.607		NaN											0	0	0	1	0	7	38				
RPS6KA2	6196	broad.mit.edu	37	6	166923801	166923801	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:166923801C>T	uc003qvb.1	-	4	562	c.343G>A	c.(343-345)GAA>AAA	p.E115K	RPS6KA2_uc011ego.1_Missense_Mutation_p.E26K|RPS6KA2_uc010kkl.1_Missense_Mutation_p.E26K|RPS6KA2_uc003qvc.1_Missense_Mutation_p.E123K|RPS6KA2_uc003qvd.1_Missense_Mutation_p.E140K|MIR1913_hsa-mir-1913|MI0008334_5'Flank	NM_021135	NP_066958	Q15349	KS6A2_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	115	Protein kinase 1.				axon guidance|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8		Breast(66;2.04e-05)|Ovarian(120;0.0652)|Prostate(117;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.76e-18)|GBM - Glioblastoma multiforme(31;9.94e-06)|BRCA - Breast invasive adenocarcinoma(81;1.36e-05)		TGATTCACTTCTGCCAAGATG	0.423		NaN											0	0	0	1	0	16	26				
MEOX2	4223	broad.mit.edu	37	7	15666538	15666538	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:15666538G>A	uc003stc.2	-	2	804	c.523C>T	c.(523-525)CAG>TAG	p.Q175*	MEOX2_uc011jxw.1_Nonsense_Mutation_p.Q175*	NM_005924	NP_005915	P50222	MEOX2_HUMAN	mesenchyme homeobox 2	175					blood circulation|multicellular organismal development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (126;0.0822)		TTTCCTTCCTGGGAGTCTGAA	0.363		NaN											0	0	0	1	0	14	60				
HOXA10	3206	broad.mit.edu	37	7	27211618	27211618	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:27211618C>T	uc011jzm.1	-	2	1163	c.1133G>A	c.(1132-1134)AGA>AAA	p.R378K	MIR196B_hsa-mir-196b|MI0001150_5'Flank|HOXA10_uc003syw.3_Missense_Mutation_p.R62K	NM_018951	NP_061824	P31260	HXA10_HUMAN	homeobox A10 isoform a	378	Homeobox.				spermatogenesis		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TTTCACTTGTCTGTCCGTGAG	0.483		NaN											0	0	0	1	0	27	84				
ANLN	54443	broad.mit.edu	37	7	36438741	36438741	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:36438741G>A	uc003tff.2	+	3	430	c.226G>A	c.(226-228)GAA>AAA	p.E76K	ANLN_uc011kaz.1_Intron|ANLN_uc003tfg.2_Missense_Mutation_p.E76K|ANLN_uc010kxe.2_Missense_Mutation_p.E76K	NM_018685	NP_061155	Q9NQW6	ANLN_HUMAN	anillin, actin binding protein	76	Nuclear localization.|Interaction with CD2AP.				cytokinesis|mitosis|regulation of exit from mitosis|septin ring assembly	actomyosin contractile ring|nucleus	actin binding			ovary(2)|skin(1)	3						TGACAACACTGAAGTAGAAGT	0.373		NaN											0	0	0	1	0	11	31				
AEBP1	165	broad.mit.edu	37	7	44144280	44144280	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:44144280G>T	uc003tkb.2	+	1	321	c.16G>T	c.(16-18)GGG>TGG	p.G6W		NM_001129	NP_001120	Q8IUX7	AEBP1_HUMAN	adipocyte enhancer binding protein 1 precursor	6					cell adhesion|muscle organ development|proteolysis|skeletal system development	cytoplasm|extracellular space|nucleus	DNA binding|metallocarboxypeptidase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						ggccgtgcgcggggcgccccT	0.368		NaN											1	0	0.004672	1	0.00472309	3	4				
ABCA13	154664	broad.mit.edu	37	7	48450206	48450206	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:48450206T>C	uc003toq.2	+	40	12185	c.12160T>C	c.(12160-12162)TGC>CGC	p.C4054R	ABCA13_uc010kys.1_Missense_Mutation_p.C1128R|ABCA13_uc010kyt.1_RNA	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	4054	ABC transporter 1.				transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						GAGGCTCAGGTGCTGCGGTCC	0.597		NaN											0	0	0	1	0	46	83				
ABCB4	5244	broad.mit.edu	37	7	87060748	87060748	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:87060748C>A	uc003uiv.1	-	15	1941	c.1865G>T	c.(1864-1866)GGG>GTG	p.G622V	ABCB4_uc003uiw.1_Missense_Mutation_p.G622V|ABCB4_uc003uix.1_Missense_Mutation_p.G622V	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	622	ABC transporter 1.|Cytoplasmic (By similarity).				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					GAAGTACACCCCTTCCTTCTT	0.413		NaN											1	0	3.52763e-06	1	3.66456e-06	18	113				
SLC25A40	55972	broad.mit.edu	37	7	87485664	87485664	+	Missense_Mutation	SNP	T	T	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:87485664T>A	uc003uje.2	-	4	451	c.100A>T	c.(100-102)ACA>TCA	p.T34S		NM_018843	NP_061331	Q8TBP6	S2540_HUMAN	mitochondrial carrier family protein	34	Solcar 1.|Helical; Name=1; (Potential).				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			haematopoietic_and_lymphoid_tissue(1)	1	Esophageal squamous(14;0.00202)					TCCAGGGGTGTCACTATGAAG	0.343		NaN											0	0	0	1	0	23	155				
ADAM22	53616	broad.mit.edu	37	7	87743932	87743932	+	Silent	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:87743932C>G	uc003ujn.2	+	6	586	c.507C>G	c.(505-507)CTC>CTG	p.L169L	ADAM22_uc003uji.1_Silent_p.L168L|ADAM22_uc003ujj.1_Silent_p.L169L|ADAM22_uc003ujk.1_Silent_p.L169L|ADAM22_uc003ujl.1_Silent_p.L169L|ADAM22_uc003ujm.2_Silent_p.L169L|ADAM22_uc003ujo.2_Silent_p.L169L|ADAM22_uc003ujp.1_Silent_p.L221L	NM_021723	NP_068369	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22 isoform 1	169					cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			ACACATATCTCATTGAGCCAG	0.398		NaN											0	0	0	1	0	11	59				
HEPACAM2	253012	broad.mit.edu	37	7	92848468	92848468	+	Missense_Mutation	SNP	T	T	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:92848468T>A	uc003umm.2	-	2	399	c.376A>T	c.(376-378)ATT>TTT	p.I126F	HEPACAM2_uc003uml.2_Missense_Mutation_p.I114F|HEPACAM2_uc010lff.2_Missense_Mutation_p.I114F|HEPACAM2_uc011khy.1_Missense_Mutation_p.I149F	NM_001039372	NP_001034461	A8MVW5	HECA2_HUMAN	HEPACAM family member 2 isoform 1	126	Extracellular (Potential).					integral to membrane				ovary(3)|breast(1)|kidney(1)	5						TTTCCCTGAATGTTGACCTTC	0.443		NaN											0	0	0	1	0	23	72				
PEG10	23089	broad.mit.edu	37	7	94293033	94293033	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:94293033G>A	uc011kie.1	+	2	610	c.393G>A	c.(391-393)GAG>GAA	p.E131E		NM_001040152	NP_001035242	Q86TG7	PEG10_HUMAN	paternally expressed 10 isoform RF1	55					apoptosis|cell differentiation|negative regulation of transforming growth factor beta receptor signaling pathway	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			central_nervous_system(1)	1	all_cancers(62;8.26e-10)|all_epithelial(64;5.59e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			CTGAGGATGAGGATGATGACA	0.587		NaN											0	0	0	1	0	3	20				
C7orf43	55262	broad.mit.edu	37	7	99755004	99755004	+	Missense_Mutation	SNP	A	A	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:99755004A>T	uc003utr.2	-	4	896	c.716T>A	c.(715-717)GTG>GAG	p.V239E	C7orf43_uc010lgo.2_5'Flank|C7orf43_uc010lgp.2_5'Flank|C7orf43_uc011kjj.1_5'UTR|C7orf43_uc003uts.2_5'UTR	NM_018275	NP_060745	Q8WVR3	CG043_HUMAN	hypothetical protein LOC55262	239											0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					ACCCTTGAGCACGGTCAAGTG	0.632		NaN									OREG0018198	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	5	41				
AP1S1	1174	broad.mit.edu	37	7	100802372	100802372	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:100802372G>A	uc003uxv.3	+	4	434	c.324G>A	c.(322-324)GAG>GAA	p.E108E		NM_001283	NP_001274	P61966	AP1S1_HUMAN	adaptor-related protein complex 1, sigma 1	108					intracellular protein transport|post-Golgi vesicle-mediated transport|receptor-mediated endocytosis|regulation of defense response to virus by virus|response to virus|viral reproduction	AP-1 adaptor complex|coated pit|cytosol|lysosomal membrane	protein binding|protein transporter activity				0	Lung NSC(181;0.168)|all_lung(186;0.215)					TCAACTTTGAGAAGGCCTACT	0.552		NaN											0	0	0	1	0	6	45				
VGF	7425	broad.mit.edu	37	7	100808035	100808035	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:100808035C>T	uc003uxx.3	-	2	308	c.90G>A	c.(88-90)GCG>GCA	p.A30A		NM_003378	NP_003369	O15240	VGF_HUMAN	VGF nerve growth factor inducible precursor	30					response to cAMP	extracellular space|transport vesicle	growth factor activity				0	Lung NSC(181;0.168)|all_lung(186;0.215)					GAGGAGGCTGCGCCTCAGGGC	0.652		NaN											0	0	0	1	0	4	21				
PSMC2	5701	broad.mit.edu	37	7	102996214	102996214	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:102996214G>C	uc003vbs.2	+	4	334	c.264G>C	c.(262-264)CAG>CAC	p.Q88H	SLC26A5_uc003vbt.1_Intron|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|PSMC2_uc011kln.1_Missense_Mutation_p.Q88H|PSMC2_uc011klo.1_Intron	NM_002803	NP_002794	P35998	PRS7_HUMAN	proteasome 26S ATPase subunit 2	88					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0						AGACACTCCAGAGTGAACAGC	0.453		NaN											0	0	0	1	0	31	22				
MLL5	55904	broad.mit.edu	37	7	104748167	104748167	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:104748167C>T	uc003vcm.2	+	22	3797	c.3263C>T	c.(3262-3264)ACA>ATA	p.T1088I	MLL5_uc010ljc.2_Missense_Mutation_p.T1088I|MLL5_uc010lje.1_RNA|MLL5_uc010ljf.1_RNA|MLL5_uc010ljg.2_5'UTR|MLL5_uc010ljh.1_5'Flank	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 5	1088					cell cycle arrest|cellular response to retinoic acid|DNA methylation|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			ovary(2)|pancreas(1)	3						AGGGACCTGACACCCTCGCAT	0.493		NaN											0	0	0	1	0	4	42				
LAMB1	3912	broad.mit.edu	37	7	107564523	107564523	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:107564523C>G	uc003vew.2	-	34	5569	c.5234G>C	c.(5233-5235)AGA>ACA	p.R1745T	LAMB1_uc003vev.2_Missense_Mutation_p.R1769T|LAMB1_uc003veu.2_Missense_Mutation_p.R228T	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	1745	Potential.|Domain I.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTCATATTTTCTTTCTAAATC	0.303		NaN											0	0	0	1	0	29	17				
LAMB1	3912	broad.mit.edu	37	7	107566684	107566684	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:107566684C>G	uc003vew.2	-	32	5343	c.5008G>C	c.(5008-5010)GAA>CAA	p.E1670Q	LAMB1_uc003vev.2_Missense_Mutation_p.E1694Q|LAMB1_uc003veu.2_Missense_Mutation_p.E153Q	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	1670	Potential.|Domain I.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TCAATATATTCTGCCTCCCCG	0.423		NaN											0	0	0	1	0	15	81				
NRCAM	4897	broad.mit.edu	37	7	107849877	107849877	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:107849877C>G	uc003vfb.2	-	12	1534	c.1063G>C	c.(1063-1065)GTT>CTT	p.V355L	NRCAM_uc003vfc.2_Missense_Mutation_p.V349L|NRCAM_uc011kmk.1_Missense_Mutation_p.V350L|NRCAM_uc003vfd.2_Missense_Mutation_p.V331L|NRCAM_uc003vfe.2_Missense_Mutation_p.V331L	NM_001037132	NP_001032209	Q92823	NRCAM_HUMAN	neuronal cell adhesion molecule isoform A	355	Ig-like 3.|Extracellular (Potential).				angiogenesis|axon guidance|axonal fasciculation|cell-cell adhesion|central nervous system development|clustering of voltage-gated sodium channels|neuron migration|positive regulation of neuron differentiation|regulation of axon extension|synapse assembly	external side of plasma membrane|integral to plasma membrane	ankyrin binding			ovary(3)|breast(2)	5						TTAACTCTAACAGAAATGGTA	0.338		NaN											0	0	0	1	0	47	61				
FOXP2	93986	broad.mit.edu	37	7	114299708	114299708	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:114299708C>T	uc003vhb.2	+	13	2001	c.1627C>T	c.(1627-1629)CGT>TGT	p.R543C	FOXP2_uc003vgu.2_RNA|FOXP2_uc003vgz.2_Missense_Mutation_p.R568C|FOXP2_uc003vha.2_Missense_Mutation_p.R451C|FOXP2_uc011kmu.1_Missense_Mutation_p.R560C|FOXP2_uc011kmv.1_Missense_Mutation_p.R542C|FOXP2_uc010ljz.1_Missense_Mutation_p.R358C|FOXP2_uc003vhe.1_Missense_Mutation_p.R113C	NM_014491	NP_055306	O15409	FOXP2_HUMAN	forkhead box P2 isoform I	543	Fork-head.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8						TTACTTCAGGCGTAATGCAGC	0.318		NaN											0	0	0	1	0	17	91				
CFTR	1080	broad.mit.edu	37	7	117232152	117232152	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:117232152T>C	uc003vjd.2	+	14	2063	c.1931T>C	c.(1930-1932)CTC>CCC	p.L644P	CFTR_uc011knq.1_Missense_Mutation_p.L50P	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	644	Cytoplasmic (Potential).|ABC transporter 1.				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	AGCTCAAAACTCATGGGATGT	0.373		NaN							Cystic_Fibrosis				0	0	0	1	0	23	86				
AASS	10157	broad.mit.edu	37	7	121773712	121773712	+	Missense_Mutation	SNP	T	T	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:121773712T>A	uc003vka.2	-	1	165	c.69A>T	c.(67-69)AAA>AAT	p.K23N	AASS_uc011knu.1_RNA|AASS_uc011knv.1_RNA|AASS_uc003vkb.2_Missense_Mutation_p.K23N|AASS_uc011knw.1_Intron	NM_005763	NP_005754	Q9UDR5	AASS_HUMAN	aminoadipate-semialdehyde synthase precursor	23					protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			upper_aerodigestive_tract(1)|ovary(1)	2					L-Glutamic Acid(DB00142)|NADH(DB00157)	CCAACACAGCTTTGTGGTGAA	0.557		NaN											0	0	0	1	0	107	72				
RNF148	378925	broad.mit.edu	37	7	122342732	122342732	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:122342732G>C	uc003vkk.1	-	1	290	c.73C>G	c.(73-75)CTA>GTA	p.L25V	CADPS2_uc010lkp.2_Intron|CADPS2_uc010lkq.2_Intron|RNF148_uc010lkr.1_Missense_Mutation_p.L25V	NM_198085	NP_932351	Q8N7C7	RN148_HUMAN	ring finger protein 148 precursor	25						integral to membrane	zinc ion binding				0						CTAAGTAGTAGAAAGATACTA	0.403		NaN											0	0	0	1	0	5	27				
SLC13A1	6561	broad.mit.edu	37	7	122839945	122839945	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:122839945G>A	uc003vkm.2	-	1	81	c.56C>T	c.(55-57)ACT>ATT	p.T19I	SLC13A1_uc010lks.2_5'UTR	NM_022444	NP_071889	Q9BZW2	S13A1_HUMAN	solute carrier family 13 (sodium/sulfate	19	Helical; (Potential).					integral to membrane|plasma membrane	sodium:sulfate symporter activity			ovary(2)	2					Succinic acid(DB00139)	AACCAACACAGTGAAAACCAC	0.433		NaN											0	0	0	1	0	25	21				
IQUB	154865	broad.mit.edu	37	7	123152297	123152297	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:123152297G>C	uc003vkn.2	-	2	675	c.98C>G	c.(97-99)TCA>TGA	p.S33*	IQUB_uc003vko.2_Nonsense_Mutation_p.S33*|IQUB_uc010lkt.2_RNA|IQUB_uc003vkp.1_Nonsense_Mutation_p.S33*|IQUB_uc003vkq.2_Nonsense_Mutation_p.S33*	NM_178827	NP_849149	Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	33										ovary(3)|large_intestine(1)	4						AGGCTCTTCTGAGGGAACTGG	0.398		NaN											0	0	0	1	0	20	133				
SPAM1	6677	broad.mit.edu	37	7	123594167	123594167	+	Silent	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:123594167C>G	uc003vld.2	+	4	945	c.543C>G	c.(541-543)CTC>CTG	p.L181L	SPAM1_uc003vle.2_Silent_p.L181L|SPAM1_uc011koa.1_5'Flank|SPAM1_uc003vlf.3_Silent_p.L181L|SPAM1_uc010lku.2_Silent_p.L181L	NM_153189	NP_694859	P38567	HYALP_HUMAN	sperm adhesion molecule 1 isoform 2	181					binding of sperm to zona pellucida|carbohydrate metabolic process|cell adhesion|fusion of sperm to egg plasma membrane	anchored to membrane|plasma membrane	hyalurononglucosaminidase activity			ovary(3)|kidney(1)	4					Hyaluronidase(DB00070)	AACTTAGTCTCACAGAGGCCA	0.388		NaN											0	0	0	1	0	22	71				
ZNF800	168850	broad.mit.edu	37	7	127014383	127014383	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:127014383G>A	uc003vlx.1	-	5	1270	c.1007C>T	c.(1006-1008)TCT>TTT	p.S336F	ZNF800_uc003vlw.1_Missense_Mutation_p.S239F|ZNF800_uc003vly.1_Missense_Mutation_p.S336F|ZNF800_uc010lla.2_Missense_Mutation_p.S336F	NM_176814	NP_789784	Q2TB10	ZN800_HUMAN	zinc finger protein 800	336					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TTTTTTAGGAGAAATAGAATC	0.373		NaN											0	0	0	1	0	35	59				
CALU	813	broad.mit.edu	37	7	128407602	128407602	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:128407602G>A	uc003vns.2	+	6	888	c.736G>A	c.(736-738)GAT>AAT	p.D246N	CALU_uc003vnq.2_Missense_Mutation_p.D246N|CALU_uc003vnr.2_Missense_Mutation_p.D246N	NM_001130674	NP_001124146	O43852	CALU_HUMAN	calumenin isoform b precursor	246	EF-hand 5.|5 (Potential).				platelet activation|platelet degranulation	extracellular region|Golgi apparatus|melanosome|sarcoplasmic reticulum lumen	calcium ion binding|protein binding				0						TAAGAACCGTGATGGGAAGAT	0.493		NaN											0	0	0	1	0	18	88				
NUP205	23165	broad.mit.edu	37	7	135303333	135303333	+	Missense_Mutation	SNP	A	A	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:135303333A>C	uc003vsw.2	+	28	3976	c.3945A>C	c.(3943-3945)TTA>TTC	p.L1315F	NUP205_uc003vsx.2_5'Flank	NM_015135	NP_055950	Q92621	NU205_HUMAN	nucleoporin 205kDa	1315					carbohydrate metabolic process|glucose transport|mRNA transport|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6						GTGATATTTTACAAGATGTGC	0.378		NaN											0	0	0	1	0	29	141				
DGKI	9162	broad.mit.edu	37	7	137271945	137271945	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:137271945G>C	uc003vtt.2	-	13	1324	c.1323C>G	c.(1321-1323)ATC>ATG	p.I441M	DGKI_uc003vtu.2_Missense_Mutation_p.I141M	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	441	DAGKc.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						GGATGGAAAGGATCCAGCCCA	0.517		NaN											0	0	0	1	0	35	27				
KIAA1549	57670	broad.mit.edu	37	7	138588413	138588413	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:138588413G>A	uc011kql.1	-	8	3639	c.3590C>T	c.(3589-3591)GCC>GTC	p.A1197V	KIAA1549_uc003vuk.3_Missense_Mutation_p.A1147V|KIAA1549_uc011kqj.1_Missense_Mutation_p.A1197V	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	1197						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						GAGCAGCTGGGCCAGCTTGCG	0.532		NaN	O	BRAF	pilocytic astrocytoma								0	0	0	1	0	6	21				
TBXAS1	6916	broad.mit.edu	37	7	139715540	139715540	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:139715540C>G	uc011kqv.1	+	12	1549	c.1385C>G	c.(1384-1386)GCT>GGT	p.A462G	TBXAS1_uc003vvh.2_Missense_Mutation_p.A416G|TBXAS1_uc010lne.2_Missense_Mutation_p.A348G|TBXAS1_uc011kqu.1_Missense_Mutation_p.A367G|TBXAS1_uc003vvi.2_Missense_Mutation_p.A416G|TBXAS1_uc003vvj.2_Missense_Mutation_p.A416G|TBXAS1_uc011kqw.1_Missense_Mutation_p.A396G	NM_001130966	NP_001124438	P24557	THAS_HUMAN	thromboxane A synthase 1, platelet isoform	415	Cytoplasmic (Potential).				hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|thromboxane-A synthase activity			ovary(2)|breast(1)	3	Melanoma(164;0.0142)					CGGGAGGCAGCTCAGGACTGC	0.647		NaN											0	0	0	1	0	13	85				
PRSS1	5644	broad.mit.edu	37	7	142459637	142459637	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:142459637G>A	uc003wak.2	+	3	230	c.213G>A	c.(211-213)GTG>GTA	p.V71V	uc011krr.1_Intron|uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_Intron|PRSS1_uc011ksm.1_3'UTR|PRSS1_uc003wam.2_Silent_p.V11V	NM_002769	NP_002760	P07477	TRY1_HUMAN	protease, serine, 1 preproprotein	71	Peptidase S1.				digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			GCATCCAGGTGAGACTGGGAG	0.577		NaN							Hereditary_Pancreatitis				0	0	0	1	0	12	198				
TAS2R40	259286	broad.mit.edu	37	7	142919411	142919411	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:142919411C>A	uc011ksx.1	+	1	240	c.240C>A	c.(238-240)TTC>TTA	p.F80L		NM_176882	NP_795363	P59535	T2R40_HUMAN	taste receptor, type 2, member 40	80	Extracellular (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			ovary(1)	1	Melanoma(164;0.059)					AGAACATTTTCAGTCTGCTAT	0.448		NaN											1	0	2.48779e-11	1	2.68302e-11	27	83				
OR2A14	135941	broad.mit.edu	37	7	143826871	143826871	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:143826871C>T	uc011kua.1	+	1	666	c.666C>T	c.(664-666)GCC>GCT	p.A222A		NM_001001659	NP_001001659	Q96R47	O2A14_HUMAN	olfactory receptor, family 2, subfamily A,	222	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Melanoma(164;0.0783)					GCATCCTGGCCGCCATCTTGA	0.612		NaN											0	0	0	1	0	114	124				
CUL1	8454	broad.mit.edu	37	7	148463737	148463737	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:148463737G>A	uc010lpg.2	+	8	1400	c.874G>A	c.(874-876)GAA>AAA	p.E292K	CUL1_uc003wey.2_Missense_Mutation_p.E292K|CUL1_uc003wez.2_Missense_Mutation_p.E182K	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	292					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			AAGGAAATGTGAACAAGTCCT	0.378		NaN											0	0	0	1	0	14	54				
PDIA4	9601	broad.mit.edu	37	7	148702271	148702271	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:148702271G>C	uc003wff.2	-	9	1766	c.1484C>G	c.(1483-1485)TCT>TGT	p.S495C		NM_004911	NP_004902	P13667	PDIA4_HUMAN	protein disulfide isomerase A4 precursor	495					cell redox homeostasis|glycerol ether metabolic process|protein secretion	endoplasmic reticulum lumen|melanosome	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			lung(5)|ovary(1)	6	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00385)			GAGGGTGTCAGAGTCAAACTC	0.597		NaN											0	0	0	1	0	8	155				
ABCB8	11194	broad.mit.edu	37	7	150737621	150737621	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:150737621G>C	uc003wil.3	+	12	1432	c.1339G>C	c.(1339-1341)GAG>CAG	p.E447Q	ABCB8_uc010lpw.1_Missense_Mutation_p.E319Q|ABCB8_uc010lpx.2_Missense_Mutation_p.E430Q|ABCB8_uc011kvd.1_Missense_Mutation_p.E342Q|ABCB8_uc003wim.3_Missense_Mutation_p.E225Q|ABCB8_uc003wik.3_Missense_Mutation_p.E430Q	NM_007188	NP_009119	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B, member 8	447						ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(2)|upper_aerodigestive_tract(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CCGGGTCTTTGAGTACATGGC	0.622		NaN											0	0	0	1	0	33	46				
ABCB8	11194	broad.mit.edu	37	7	150737667	150737667	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:150737667G>T	uc003wil.3	+	12	1478	c.1385G>T	c.(1384-1386)TGC>TTC	p.C462F	ABCB8_uc010lpw.1_Missense_Mutation_p.C334F|ABCB8_uc010lpx.2_Missense_Mutation_p.C445F|ABCB8_uc011kvd.1_Missense_Mutation_p.C357F|ABCB8_uc003wim.3_Missense_Mutation_p.C240F|ABCB8_uc003wik.3_Missense_Mutation_p.C445F	NM_007188	NP_009119	Q9NUT2	ABCB8_HUMAN	ATP-binding cassette, sub-family B, member 8	462						ATP-binding cassette (ABC) transporter complex|integral to membrane|membrane fraction|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(2)|upper_aerodigestive_tract(1)	3			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		GGGGGCTGCTGCGTCCCCAAA	0.647		NaN											1	0	1.42033e-22	1	1.59083e-22	34	48				
MLL3	58508	broad.mit.edu	37	7	151962147	151962147	+	Missense_Mutation	SNP	T	T	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08			T	A	T	T		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:151962147T>A	uc003wla.2	-	8	1379	c.1160A>T	c.(1159-1161)GAG>GTG	p.E387V		NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	387	PHD-type 1.|RING-type.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CACTTTGCACTCAGGACATTG	0.413		NaN	N		medulloblastoma								0	0	0	1	0	22	241		Valid		
RBM33	155435	broad.mit.edu	37	7	155534734	155534734	+	Silent	SNP	G	G	A	rs113181766		TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:155534734G>A	uc010lqk.1	+	13	2639	c.2271G>A	c.(2269-2271)ACG>ACA	p.T757T	RBM33_uc011kvv.1_Silent_p.T566T	NM_053043	NP_444271	Q96EV2	RBM33_HUMAN	RNA binding motif protein 33	757							nucleotide binding|RNA binding			ovary(1)	1	all_neural(206;0.101)	all_hematologic(28;0.0592)	OV - Ovarian serous cystadenocarcinoma(82;0.011)	UCEC - Uterine corpus endometrioid carcinoma (81;0.2)		AGGGAAAGACGGAAGTGAAAG	0.547		NaN											0	0	0	1	0	9	41				
CSMD1	64478	broad.mit.edu	37	8	3009031	3009031	+	Silent	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:3009031G>T	uc011kwk.1	-	40	6312	c.5922C>A	c.(5920-5922)ACC>ACA	p.T1974T	CSMD1_uc011kwj.1_Silent_p.T1366T|CSMD1_uc003wqe.2_Silent_p.T1130T|CSMD1_uc010lrg.2_Silent_p.T42T	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1974	Extracellular (Potential).					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		TCCCTCCACAGGTTGCTGTTA	0.527		NaN											1	0	0.00909568	1	0.00914966	3	2				
PNOC	5368	broad.mit.edu	37	8	28196682	28196682	+	Silent	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:28196682C>A	uc010lva.2	+	3	460	c.252C>A	c.(250-252)CTC>CTA	p.L84L	PNOC_uc003xgp.2_Silent_p.L84L|PNOC_uc011lau.1_Silent_p.L20L	NM_006228	NP_006219	Q13519	PNOC_HUMAN	prepronociceptin precursor	84					neuropeptide signaling pathway|sensory perception|synaptic transmission	extracellular region	neuropeptide hormone activity|opioid peptide activity			central_nervous_system(1)	1		Ovarian(32;0.000953)		KIRC - Kidney renal clear cell carcinoma(542;0.104)|Kidney(114;0.125)|Colorectal(74;0.145)|BRCA - Breast invasive adenocarcinoma(99;0.245)		CGGCTGCTCTCTACCAGCCGA	0.652		NaN											1	0	7.45023e-12	1	8.06909e-12	20	4				
KCNU1	157855	broad.mit.edu	37	8	36697995	36697995	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:36697995G>C	uc010lvw.2	+	15	1620	c.1533G>C	c.(1531-1533)CAG>CAC	p.Q511H	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	511	Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		TGCCTAAACAGACCTGGAAGA	0.403		NaN											0	0	0	1	0	5	34				
UBE2V2	7336	broad.mit.edu	37	8	48973350	48973350	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:48973350C>G	uc003xqm.2	+	4	421	c.400C>G	c.(400-402)CTT>GTT	p.L134V		NM_003350	NP_003341	Q15819	UB2V2_HUMAN	ubiquitin-conjugating enzyme E2v2	134					cell proliferation|DNA double-strand break processing|protein polyubiquitination|regulation of DNA repair	cytoplasm|nucleus|UBC13-MMS2 complex	acid-amino acid ligase activity|protein binding				0		all_cancers(86;0.026)|all_epithelial(80;0.000748)|Lung NSC(129;0.00171)|all_lung(136;0.00196)				AAATATGAAGCTTCCACAGCC	0.353		NaN						Direct_reversal_of_damage|Rad6_pathway					0	0	0	1	0	13	79				
CHD7	55636	broad.mit.edu	37	8	61654316	61654316	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:61654316C>A	uc003xue.2	+	2	802	c.325C>A	c.(325-327)CCC>ACC	p.P109T		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	109					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			TCACACCCCTCCCGTTCCTCA	0.567		NaN											1	0	2.32078e-09	1	2.46887e-09	16	20		Valid		
DNAJC5B	85479	broad.mit.edu	37	8	66963882	66963882	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:66963882G>C	uc003xvs.1	+	3	391	c.100G>C	c.(100-102)GAA>CAA	p.E34Q	DNAJC5B_uc003xvt.1_RNA	NM_033105	NP_149096	Q9UF47	DNJ5B_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 5	34	J.				protein folding	membrane	heat shock protein binding|unfolded protein binding				0		Lung NSC(129;0.114)|all_lung(136;0.188)	Epithelial(68;0.0213)|all cancers(69;0.0839)|BRCA - Breast invasive adenocarcinoma(89;0.0886)|OV - Ovarian serous cystadenocarcinoma(28;0.112)			ATCAAATGAAGAAATTAAGAA	0.393		NaN											0	0	0	1	0	13	99				
CPA6	57094	broad.mit.edu	37	8	68536432	68536432	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:68536432C>T	uc003xxq.3	-	2	427	c.171G>A	c.(169-171)AAG>AAA	p.K57K	CPA6_uc003xxr.3_5'UTR|CPA6_uc003xxs.2_Silent_p.K57K	NM_020361	NP_065094	Q8N4T0	CBPA6_HUMAN	carboxypeptidase A6 isoform 1 precursor	57					proteolysis	proteinaceous extracellular matrix	metallocarboxypeptidase activity|zinc ion binding			ovary(2)	2			Epithelial(68;0.04)|OV - Ovarian serous cystadenocarcinoma(28;0.0593)|all cancers(69;0.136)			AGGATATTTTCTTCAGTGCAT	0.318		NaN											0	0	0	1	0	37	15				
SLCO5A1	81796	broad.mit.edu	37	8	70650368	70650368	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:70650368C>A	uc003xyl.2	-	5	2037	c.1330G>T	c.(1330-1332)GAG>TAG	p.E444*	SLCO5A1_uc010lzb.2_Intron|SLCO5A1_uc011lfa.1_Intron|SLCO5A1_uc003xyk.2_Nonsense_Mutation_p.E444*|SLCO5A1_uc010lzc.2_Intron	NM_030958	NP_112220	Q9H2Y9	SO5A1_HUMAN	solute carrier organic anion transporter family,	444	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|upper_aerodigestive_tract(1)	4	Breast(64;0.0654)		Epithelial(68;0.0141)|OV - Ovarian serous cystadenocarcinoma(28;0.0315)|all cancers(69;0.0594)			ATGGCACTCTCAGCTGTGTAT	0.423		NaN											1	0	2.48254e-18	1	2.75928e-18	51	35				
TRAM1	23471	broad.mit.edu	37	8	71520314	71520314	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:71520314C>G	uc003xyo.1	-	1	291	c.121G>C	c.(121-123)GAG>CAG	p.E41Q	TRAM1_uc011lfc.1_Missense_Mutation_p.E10Q	NM_014294	NP_055109	Q15629	TRAM1_HUMAN	translocation associated membrane protein 1	41	Helical; (Potential).				cotranslational protein targeting to membrane|transmembrane transport	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity			ovary(1)	1			Epithelial(68;0.00679)|all cancers(69;0.0324)|OV - Ovarian serous cystadenocarcinoma(28;0.0509)			GGGCTCACCTCAAACATGAGC	0.692		NaN											0	0	0	1	0	19	4				
LACTB2	51110	broad.mit.edu	37	8	71550853	71550853	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:71550853C>G	uc011lfd.1	-	6	845	c.753G>C	c.(751-753)GAG>GAC	p.E251D	LACTB2_uc003xyp.2_Missense_Mutation_p.E251D	NM_016027	NP_057111	Q53H82	LACB2_HUMAN	lactamase, beta 2	251							hydrolase activity|metal ion binding			ovary(1)	1	Breast(64;0.0716)		Epithelial(68;0.00319)|all cancers(69;0.0175)|OV - Ovarian serous cystadenocarcinoma(28;0.0628)|BRCA - Breast invasive adenocarcinoma(89;0.166)			CATGTAAATTCTCAGGAGTAT	0.244		NaN											0	0	0	1	0	34	18				
PI15	51050	broad.mit.edu	37	8	75737667	75737667	+	Silent	SNP	C	C	T	rs147092656	by1000genomes	TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:75737667C>T	uc003yal.2	+	2	362	c.183C>T	c.(181-183)TAC>TAT	p.Y61Y	uc003yak.1_Intron|PI15_uc003yam.2_Silent_p.Y61Y	NM_015886	NP_056970	O43692	PI15_HUMAN	protease inhibitor 15 preproprotein	61						extracellular region	peptidase inhibitor activity			central_nervous_system(2)|ovary(1)	3	Breast(64;0.137)		BRCA - Breast invasive adenocarcinoma(89;0.104)|Epithelial(68;0.118)			GGAAGCGCTACATTTCGCAGA	0.443		NaN											0	0	0	1	0	49	42				
RALYL	138046	broad.mit.edu	37	8	85441685	85441685	+	Silent	SNP	A	A	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:85441685A>G	uc003ycq.3	+	3	545	c.129A>G	c.(127-129)TCA>TCG	p.S43S	RALYL_uc003ycr.3_Silent_p.S43S|RALYL_uc003ycs.3_Silent_p.S43S|RALYL_uc010lzy.2_Silent_p.S43S|RALYL_uc003yct.3_Silent_p.S56S	NM_001100392	NP_001093862	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like isoform 2	43	RRM.						identical protein binding|nucleotide binding|RNA binding			ovary(1)	1						CCATTTTTTCAAAGTATGGAA	0.408		NaN											0	0	0	1	0	16	17				
PSKH2	85481	broad.mit.edu	37	8	87076268	87076268	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:87076268G>A	uc011lfy.1	-	2	778	c.778C>T	c.(778-780)CTG>TTG	p.L260L		NM_033126	NP_149117	Q96QS6	KPSH2_HUMAN	protein serine kinase H2	260	Protein kinase.						ATP binding|protein serine/threonine kinase activity			stomach(2)|lung(2)|ovary(1)	5			STAD - Stomach adenocarcinoma(118;0.129)			TCAAAAGGCAGGAATCCGCTA	0.403		NaN											0	0	0	1	0	37	41				
POP1	10940	broad.mit.edu	37	8	99142401	99142401	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:99142401G>C	uc003yij.3	+	5	782	c.682G>C	c.(682-684)GTC>CTC	p.V228L	POP1_uc011lgv.1_Missense_Mutation_p.V228L|POP1_uc003yik.2_Missense_Mutation_p.V228L	NM_001145860	NP_001139332	Q99575	POP1_HUMAN	processing of precursor 1	228					tRNA 5'-leader removal|tRNA catabolic process	nucleolar ribonuclease P complex|ribonuclease MRP complex	identical protein binding|ribonuclease MRP activity|ribonuclease P activity			ovary(1)|breast(1)	2	Breast(36;1.78e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.145)			GAGGCCAACAGTCAAGAGCCA	0.483		NaN											0	0	0	1	0	31	95				
VPS13B	157680	broad.mit.edu	37	8	100844696	100844696	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:100844696G>C	uc003yiv.2	+	52	9616	c.9505G>C	c.(9505-9507)GAC>CAC	p.D3169H	VPS13B_uc003yiw.2_Missense_Mutation_p.D3144H	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3169					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CTTGATGCCTGACATCAGTCA	0.522		NaN											0	0	0	1	0	16	30				
VPS13B	157680	broad.mit.edu	37	8	100866115	100866115	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:100866115G>A	uc003yiv.2	+	56	10684	c.10573G>A	c.(10573-10575)GAA>AAA	p.E3525K	VPS13B_uc003yiw.2_Missense_Mutation_p.E3500K	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3525					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			GTTCAGCTTTGAATTAAAACC	0.383		NaN											0	0	0	1	0	41	178				
SPAG1	6674	broad.mit.edu	37	8	101253173	101253173	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:101253173G>C	uc003yjh.1	+	19	2790	c.2704G>C	c.(2704-2706)GAG>CAG	p.E902Q	SPAG1_uc003yji.1_Missense_Mutation_p.E902Q	NM_172218	NP_757367	Q07617	SPAG1_HUMAN	sperm associated antigen 1	902					single fertilization	cytoplasm	GTP binding|hydrolase activity			ovary(2)|central_nervous_system(1)	3	all_cancers(14;2.35e-05)|all_epithelial(15;5.2e-08)|Lung NSC(17;0.000283)|all_lung(17;0.000823)	Breast(495;0.195)	Epithelial(11;1.12e-09)|all cancers(13;1.26e-07)|OV - Ovarian serous cystadenocarcinoma(57;4.37e-05)|STAD - Stomach adenocarcinoma(118;0.0525)	KIRC - Kidney renal clear cell carcinoma(542;0.00178)|READ - Rectum adenocarcinoma(644;0.236)		ACAGCTGTTTGAGGACCTTTC	0.333		NaN											0	0	0	1	0	10	112				
UBR5	51366	broad.mit.edu	37	8	103298599	103298599	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:103298599G>C	uc003ykr.1	-	38	5237	c.5204C>G	c.(5203-5205)TCT>TGT	p.S1735C	UBR5_uc003yks.1_Missense_Mutation_p.S1735C	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	1735					cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			TGCTGGTGTAGATGTACTGGA	0.453		NaN											0	0	0	1	0	5	61				
FZD6	8323	broad.mit.edu	37	8	104337017	104337017	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:104337017G>A	uc003ylh.2	+	4	967	c.683G>A	c.(682-684)AGA>AAA	p.R228K	FZD6_uc003yli.2_Missense_Mutation_p.R228K|FZD6_uc003ylj.2_Missense_Mutation_p.R228K|FZD6_uc011lhn.1_Missense_Mutation_p.R194K|FZD6_uc011lho.1_Intron|FZD6_uc011lhp.1_Missense_Mutation_p.R173K	NM_003506	NP_003497	O60353	FZD6_HUMAN	frizzled 6 isoform a precursor	228	Cytoplasmic (Potential).				angiogenesis|axonogenesis|cell proliferation in midbrain|establishment of planar polarity|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|neural tube closure|non-canonical Wnt receptor signaling pathway	apical part of cell|apicolateral plasma membrane|cytoplasm|integral to plasma membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(57;2.86e-05)|STAD - Stomach adenocarcinoma(118;0.197)			AGAAGATTCAGATACCCAGAG	0.338		NaN											0	0	0	1	0	26	57				
RIMS2	9699	broad.mit.edu	37	8	104955043	104955043	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:104955043C>T	uc003yls.2	+	12	2165	c.1924C>T	c.(1924-1926)CAT>TAT	p.H642Y	RIMS2_uc003ylp.2_Missense_Mutation_p.H864Y|RIMS2_uc003ylw.2_Missense_Mutation_p.H656Y|RIMS2_uc003ylq.2_Missense_Mutation_p.H656Y|RIMS2_uc003ylr.2_Missense_Mutation_p.H703Y|RIMS2_uc003ylt.2_Missense_Mutation_p.H249Y	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	926					intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			TGATGAGCCACATTGGTACAA	0.393		NaN								HNSCC(12;0.0054)			0	0	0	1	0	11	62				
ZFPM2	23414	broad.mit.edu	37	8	106815184	106815184	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:106815184C>G	uc003ymd.2	+	8	2897	c.2874C>G	c.(2872-2874)AAC>AAG	p.N958K	ZFPM2_uc011lhs.1_Missense_Mutation_p.N689K	NM_012082	NP_036214	Q8WW38	FOG2_HUMAN	zinc finger protein, multitype 2	958					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			ovary(4)|large_intestine(1)	5			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			AAGAAGAAAACAGACATTTGT	0.428		NaN											0	0	0	1	0	7	30				
TAF2	6873	broad.mit.edu	37	8	120768248	120768248	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:120768248G>A	uc003you.2	-	22	3146	c.2876C>T	c.(2875-2877)TCT>TTT	p.S959F		NM_003184	NP_003175	Q6P1X5	TAF2_HUMAN	TBP-associated factor 2	959					G2/M transition of mitotic cell cycle|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	transcription factor TFIID complex|transcription factor TFTC complex	metallopeptidase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			large_intestine(2)|ovary(2)|kidney(1)|skin(1)	6	Lung NSC(37;9.35e-07)|Ovarian(258;0.011)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00185)			TCTCTCACCAGAATTCATAAG	0.323		NaN											0	0	0	1	0	29	75				
WDR67	93594	broad.mit.edu	37	8	124109655	124109655	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:124109655G>C	uc003ypp.1	+	6	895	c.805G>C	c.(805-807)GAT>CAT	p.D269H	WDR67_uc011lig.1_Missense_Mutation_p.D269H|WDR67_uc011lih.1_Missense_Mutation_p.D159H|WDR67_uc003ypq.1_RNA|WDR67_uc003ypo.1_Missense_Mutation_p.D269H|WDR67_uc003ypr.2_RNA	NM_145647	NP_663622	Q96DN5	WDR67_HUMAN	WD repeat domain 67 isoform 1	269						centrosome	Rab GTPase activator activity			skin(1)	1	Lung NSC(37;7e-10)|Ovarian(258;0.0205)		STAD - Stomach adenocarcinoma(47;0.00527)			ATTTCTTCCTGATAGTTTTGA	0.398		NaN											0	0	0	1	0	5	72				
C8orf76	84933	broad.mit.edu	37	8	124243745	124243745	+	Missense_Mutation	SNP	A	A	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:124243745A>C	uc003yqc.1	-	4	641	c.610T>G	c.(610-612)TTC>GTC	p.F204V	C8orf76_uc003yqd.2_Missense_Mutation_p.F172V	NM_032847	NP_116236	Q96K31	CH076_HUMAN	hypothetical protein LOC84933	204							binding			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			TGTGGAAAGAAGGATTTGATA	0.448		NaN											0	0	0	1	0	75	97				
ZHX1	11244	broad.mit.edu	37	8	124267094	124267094	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:124267094G>C	uc003yqe.2	-	3	1523	c.1093C>G	c.(1093-1095)CAG>GAG	p.Q365E	C8orf76_uc003yqd.2_Intron|ZHX1_uc003yqf.2_Missense_Mutation_p.Q365E|ZHX1_uc003yqg.2_Intron|ZHX1_uc010mdi.2_Missense_Mutation_p.Q365E	NM_007222	NP_009153	Q9UKY1	ZHX1_HUMAN	zinc fingers and homeoboxes 1	365	Required for dimerization.|Required for interaction with NFYA.				negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			GTTATGGTCTGAGGTACAGTA	0.433		NaN											0	0	0	1	0	38	241				
WDYHV1	55093	broad.mit.edu	37	8	124453558	124453558	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:124453558A>G	uc003yqn.1	+	6	646	c.521A>G	c.(520-522)AAC>AGC	p.N174S	WDYHV1_uc011lij.1_Missense_Mutation_p.N114S|WDYHV1_uc003yqo.1_RNA	NM_018024	NP_060494	Q96HA8	NTAQ1_HUMAN	WDYHV motif containing 1	174					protein modification process	cytosol|nucleus	protein binding|protein N-terminal glutamine amidohydrolase activity			ovary(1)|skin(1)	2						TCCAAAATGAACCTGAACGAT	0.368		NaN											0	0	0	1	0	120	47				
RNF139	11236	broad.mit.edu	37	8	125487416	125487416	+	Silent	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:125487416C>G	uc003yrc.2	+	1	409	c.66C>G	c.(64-66)CTC>CTG	p.L22L	uc003yrb.2_5'Flank	NM_007218	NP_009149	Q8WU17	RN139_HUMAN	ring finger protein 139	22					negative regulation of cell proliferation|regulation of protein ubiquitination	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			kidney(1)	1	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			GGGCGGCGCTCGAAGTGGCGC	0.632		NaN							Renal_Cell_Cancer_associated_with_constitutional_translocation_of_chromosome_3				0	0	0	1	0	8	71				
RNF139	11236	broad.mit.edu	37	8	125499414	125499414	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:125499414C>G	uc003yrc.2	+	2	1867	c.1524C>G	c.(1522-1524)ATC>ATG	p.I508M		NM_007218	NP_009149	Q8WU17	RN139_HUMAN	ring finger protein 139	508	Helical; (Potential).				negative regulation of cell proliferation|regulation of protein ubiquitination	endoplasmic reticulum membrane|integral to membrane	protein binding|receptor activity|ubiquitin-protein ligase activity|zinc ion binding			kidney(1)	1	Ovarian(258;0.00438)|all_neural(195;0.0779)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.00288)			ATTTTAACATCTACTTACAAG	0.378		NaN							Renal_Cell_Cancer_associated_with_constitutional_translocation_of_chromosome_3				0	0	0	1	0	20	151				
ASAP1	50807	broad.mit.edu	37	8	131140337	131140337	+	Splice_Site	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:131140337C>T	uc003yta.1	-	15	1246	c.1218_splice	c.e15-1	p.A406_splice	ASAP1_uc003ysz.1_Splice_Site_p.A217_splice|ASAP1_uc011liw.1_Splice_Site_p.A399_splice	NM_018482	NP_060952	Q9ULH1	ASAP1_HUMAN	development and differentiation enhancing factor						cilium morphogenesis|filopodium assembly|regulation of ARF GTPase activity|signal transduction	cytoplasm|membrane	ARF GTPase activator activity|cytoskeletal adaptor activity|SH3 domain binding|zinc ion binding			ovary(4)	4						TGATATCCATCTGTTGGTAAA	0.363		NaN											0	0	0	1	0	25	37				
TG	7038	broad.mit.edu	37	8	133879281	133879281	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:133879281C>T	uc003ytw.2	+	1	77	c.36C>T	c.(34-36)GCC>GCT	p.A12A		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	12					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		CCCTGCTGGCCTCCATCTGCT	0.547		NaN											0	0	0	1	0	3	8				
SLA	6503	broad.mit.edu	37	8	134057253	134057253	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:134057253C>G	uc003ytz.2	-	7	1292	c.460G>C	c.(460-462)GAG>CAG	p.E154Q	TG_uc003ytw.2_Intron|TG_uc010mdw.2_Intron|TG_uc011ljb.1_Intron|TG_uc011ljc.1_Intron|SLA_uc011lje.1_Missense_Mutation_p.E171Q|SLA_uc011ljf.1_Missense_Mutation_p.E46Q|SLA_uc011ljg.1_Intron|SLA_uc011ljd.1_Missense_Mutation_p.E194Q	NM_001045556	NP_001039021	Q13239	SLAP1_HUMAN	Src-like-adaptor isoform a	154	SH2.					endosome	SH3/SH2 adaptor activity			lung(1)|liver(1)	2	all_epithelial(106;3.51e-21)|Lung NSC(106;4.24e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0279)|Breast(495;0.037)	BRCA - Breast invasive adenocarcinoma(115;0.000701)			ACCAGGTCCTCCAGGCACTGG	0.517		NaN											0	0	0	1	0	8	92				
TG	7038	broad.mit.edu	37	8	134108561	134108561	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:134108561C>T	uc003ytw.2	+	43	7557	c.7516C>T	c.(7516-7518)CTG>TTG	p.L2506L	TG_uc010mdw.2_Silent_p.L1265L|TG_uc011ljb.1_Silent_p.L875L|TG_uc011ljc.1_Silent_p.L639L|SLA_uc003ytz.2_Intron|SLA_uc011lje.1_Intron|SLA_uc011ljf.1_Intron|SLA_uc011ljg.1_Intron|SLA_uc010mea.2_Intron	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	2506					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AGAGGTCGATCTGCTCATTGG	0.577		NaN											0	0	0	1	0	26	237				
TRAPPC9	83696	broad.mit.edu	37	8	140744407	140744407	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:140744407C>T	uc003yvj.2	-	22	3228	c.3094G>A	c.(3094-3096)GTG>ATG	p.V1032M	TRAPPC9_uc003yvh.2_Missense_Mutation_p.V1130M	NM_001160372	NP_001153844	Q96Q05	TPPC9_HUMAN	trafficking protein particle complex 9 isoform	1032					cell differentiation	endoplasmic reticulum|Golgi apparatus				skin(2)	2						CAGGCCGCCACAGCCTCGCGG	0.716		NaN											0	0	0	1	0	11	17				
CHRAC1	54108	broad.mit.edu	37	8	141525224	141525224	+	Splice_Site	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:141525224G>C	uc003yvl.2	+	3	473	c.275_splice	c.e3-1	p.D92_splice	CHRAC1_uc010mem.1_Splice_Site	NM_017444	NP_059140	Q9NRG0	CHRC1_HUMAN	chromatin accessibility complex 1						chromatin remodeling	chromatin accessibility complex|epsilon DNA polymerase complex	DNA-directed DNA polymerase activity|sequence-specific DNA binding			ovary(1)	1	all_cancers(97;5.52e-16)|all_epithelial(106;1.22e-13)|Lung NSC(106;4.09e-06)|all_lung(105;6e-06)|Ovarian(258;0.0154)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.107)			ATGTTTTTAAGATATATTACC	0.333		NaN											0	0	0	1	0	14	204				
FAM83H	286077	broad.mit.edu	37	8	144810771	144810771	+	Missense_Mutation	SNP	G	G	A	rs137854442		TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:144810771G>A	uc003yzk.2	-	5	929	c.860C>T	c.(859-861)TCG>TTG	p.S287L	FAM83H_uc010mfk.1_RNA	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	287					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GGCCGCGGCCGAGGGCACAAG	0.711		NaN											0	0	0	1	0	6	12				
FAM83H	286077	broad.mit.edu	37	8	144812730	144812730	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:144812730G>A	uc003yzk.2	-	2	92	c.23C>T	c.(22-24)TCC>TTC	p.S8F	FAM83H_uc010mfk.1_5'Flank	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	8					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CCCCTGCGAGGAGCTCTGAGA	0.677		NaN											0	0	0	1	0	8	24				
EPPK1	83481	broad.mit.edu	37	8	144942543	144942543	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:144942543C>T	uc003zaa.1	-	1	4892	c.4879G>A	c.(4879-4881)GAG>AAG	p.E1627K		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	1627	Plectin 27.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TTGAACGCCTCCTCCACGGTC	0.637		NaN											0	0	0	1	0	22	65				
PARP10	84875	broad.mit.edu	37	8	145059158	145059158	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:145059158C>G	uc003zal.3	-	5	1120	c.1012G>C	c.(1012-1014)GGT>CGT	p.G338R	PARP10_uc003zak.3_Missense_Mutation_p.G44R|PARP10_uc011lku.1_Missense_Mutation_p.G350R|PARP10_uc011lkv.1_RNA|PARP10_uc003zam.2_Missense_Mutation_p.G338R|PARP10_uc010mfn.1_Missense_Mutation_p.G253R|PARP10_uc010mfo.1_3'UTR	NM_032789	NP_116178	Q53GL7	PAR10_HUMAN	poly (ADP-ribose) polymerase family, member 10	338						Golgi apparatus|nucleolus	NAD+ ADP-ribosyltransferase activity|nucleotide binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)|pancreas(1)	6	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CCCATGGGACCTGTCCTCAGA	0.612		NaN											0	0	0	1	0	65	68				
GPAA1	8733	broad.mit.edu	37	8	145140309	145140309	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:145140309G>T	uc003zax.2	+	10	1488	c.1378G>T	c.(1378-1380)GAG>TAG	p.E460*		NM_003801	NP_003792	O43292	GPAA1_HUMAN	glycosylphosphatidylinositol anchor attachment	460	Helical; (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|protein complex assembly|protein retention in ER lumen	GPI-anchor transamidase complex	tubulin binding				0	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.02e-40)|all cancers(56;2.11e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CCCAGTGGCAGAGGCTGAGGC	0.632		NaN											1	0	0.00909568	1	0.00914966	4	35				
GPAA1	8733	broad.mit.edu	37	8	145140621	145140621	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:145140621G>T	uc003zax.2	+	11	1707	c.1597G>T	c.(1597-1599)GCG>TCG	p.A533S		NM_003801	NP_003792	O43292	GPAA1_HUMAN	glycosylphosphatidylinositol anchor attachment	533	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|protein complex assembly|protein retention in ER lumen	GPI-anchor transamidase complex	tubulin binding				0	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.02e-40)|all cancers(56;2.11e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			GCCCACTGCTGCGCTTGCCAA	0.612		NaN											1	0	2.80697e-09	1	2.97985e-09	10	122				
ZNF7	7553	broad.mit.edu	37	8	146067042	146067042	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:146067042C>G	uc003zeg.3	+	5	687	c.550C>G	c.(550-552)CTT>GTT	p.L184V	ZNF7_uc010mge.2_Missense_Mutation_p.L195V|ZNF7_uc011lln.1_Missense_Mutation_p.L88V|ZNF7_uc003zeh.2_Intron|ZNF7_uc003zek.3_Missense_Mutation_p.L88V|COMMD5_uc003zel.1_RNA	NM_003416	NP_003407	P17097	ZNF7_HUMAN	zinc finger protein 7	184					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(4)	4	all_cancers(97;1.03e-11)|all_epithelial(106;6.69e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)	Breast(495;0.0812)|Ovarian(118;0.0822)|Acute lymphoblastic leukemia(644;0.143)	Epithelial(56;8.75e-39)|OV - Ovarian serous cystadenocarcinoma(54;1.13e-38)|all cancers(56;8.48e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)	GBM - Glioblastoma multiforme(99;2.11e-07)		TTGTCAGCCTCTTGAAAGTCA	0.537		NaN											0	0	0	1	0	13	85				
MLANA	2315	broad.mit.edu	37	9	5908664	5908664	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:5908664G>C	uc003zjo.1	+	5	366	c.313G>C	c.(313-315)GAG>CAG	p.E105Q		NM_005511	NP_005502	Q16655	MAR1_HUMAN	melan-A	105	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to plasma membrane|melanosome|trans-Golgi network	protein binding				0		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(1;1.15e-06)|Lung(218;0.103)		ACCTGCTTATGAGAAACTCTC	0.433		NaN											0	0	0	1	0	26	28				
KIAA2026	158358	broad.mit.edu	37	9	5954074	5954074	+	Missense_Mutation	SNP	T	T	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:5954074T>G	uc003zjq.3	-	4	2450	c.2234A>C	c.(2233-2235)AAA>ACA	p.K745T	KIAA2026_uc010mht.2_5'UTR	NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	745	Lys-rich.									ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		TGTGATTGCTTTTTTAGAGAC	0.308		NaN											0	0	0	1	0	2	1				
PSIP1	11168	broad.mit.edu	37	9	15490123	15490123	+	Splice_Site	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:15490123C>A	uc003zlv.3	-	4	480	c.150_splice	c.e4-1	p.T50_splice	PSIP1_uc003zlw.3_Splice_Site_p.T50_splice|PSIP1_uc003zlz.3_Splice_Site_p.T50_splice|PSIP1_uc003zma.3_Splice_Site_p.T50_splice|PSIP1_uc003zly.2_Splice_Site_p.T50_splice	NM_033222	NP_150091	O75475	PSIP1_HUMAN	PC4 and SFRS1 interacting protein 1 isoform 2						initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(1)	1				GBM - Glioblastoma multiforme(50;2.38e-06)		TAAAAAAGCACTAAAAAAGAA	0.313		NaN											1	0	1.15088e-07	1	1.21289e-07	14	1				
CDKN2A	1029	broad.mit.edu	37	9	21974736	21974736	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:21974736G>C	uc003zpk.2	-	1	303	c.91C>G	c.(91-93)CTG>GTG	p.L31V	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_Missense_Mutation_p.L31V|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Intron	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	31	ANK 1.				cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(23)|p.V28_E33del(2)|p.R29_A34del(2)|p.V28_V51del(1)|p.R29fs*9(1)|p.L31P(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		GCCTCCAGCAGCGCCCGCACC	0.736		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			0	0	0	1	0	10	19		Valid		
TAF1L	138474	broad.mit.edu	37	9	32630951	32630951	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:32630951C>G	uc003zrg.1	-	1	4717	c.4627G>C	c.(4627-4629)GAT>CAT	p.D1543H	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	1543	Bromo 2.				male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		GGCCAAGAATCTGGAACTGCC	0.388		NaN											0	0	0	1	0	8	49				
PRSS3	5646	broad.mit.edu	37	9	33797839	33797839	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:33797839G>A	uc003ztj.3	+	3	384	c.384G>A	c.(382-384)GTG>GTA	p.V128V	uc003ztk.1_Intron|PRSS3_uc003zti.3_Silent_p.V85V|PRSS3_uc003ztl.3_Silent_p.V71V	NM_007343	NP_031369	P35030	TRY3_HUMAN	mesotrypsin isoform 1 preproprotein	128	Peptidase S1.				digestion|endothelial cell migration|zymogen activation	extracellular space	calcium ion binding|protein binding|serine-type endopeptidase activity|serine-type peptidase activity				0			LUSC - Lung squamous cell carcinoma(29;0.0176)			GCATCCAGGTGAGACTGGGAG	0.587		NaN											0	0	0	1	0	4	48				
TLN1	7094	broad.mit.edu	37	9	35698825	35698825	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:35698825C>G	uc003zxt.2	-	53	7459	c.7105G>C	c.(7105-7107)GAA>CAA	p.E2369Q		NM_006289	NP_006280	Q9Y490	TLN1_HUMAN	talin 1	2369	I/LWEQ.				axon guidance|cell adhesion|cell-cell junction assembly|cellular component movement|cytoskeletal anchoring at plasma membrane|muscle contraction|platelet activation|platelet degranulation	actin cytoskeleton|centrosome|cytosol|extracellular region|focal adhesion|intracellular membrane-bounded organelle|ruffle membrane	actin binding|insulin receptor binding|LIM domain binding|structural constituent of cytoskeleton|vinculin binding			lung(7)|breast(3)|ovary(2)|central_nervous_system(1)	13	all_epithelial(49;0.167)		Lung(28;0.00276)|LUSC - Lung squamous cell carcinoma(32;0.00418)|STAD - Stomach adenocarcinoma(86;0.194)			GCCACTAGTTCTCTCTGGGCA	0.522		NaN											0	0	0	1	0	15	30				
SMC5	23137	broad.mit.edu	37	9	72892386	72892386	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:72892386C>T	uc004ahr.2	+	4	658	c.541C>T	c.(541-543)CAG>TAG	p.Q181*		NM_015110	NP_055925	Q8IY18	SMC5_HUMAN	SMC5 protein	181					DNA recombination|DNA repair	chromosome|nucleus	ATP binding			ovary(2)|central_nervous_system(1)	3						GTTTCTCCCTCAGGTATGAGA	0.338		NaN											0	0	0	1	0	16	19				
FAM108B1	51104	broad.mit.edu	37	9	74489886	74489886	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:74489886C>T	uc004aim.1	-	2	713	c.111G>A	c.(109-111)CTG>CTA	p.L37L	FAM108B1_uc004ail.2_Silent_p.L37L	NM_001025780	NP_001020951	Q5VST6	F108B_HUMAN	family with sequence similarity 108, member B1	37						extracellular region	hydrolase activity				0						CATCACACATCAGTGTGTAAG	0.428		NaN											0	0	0	1	0	7	74				
ROR2	4920	broad.mit.edu	37	9	94487117	94487117	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:94487117G>A	uc004arj.1	-	9	1858	c.1659C>T	c.(1657-1659)TTC>TTT	p.F553F	ROR2_uc004ari.1_Silent_p.F413F	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	553	Cytoplasmic (Potential).|Protein kinase.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20						AACAGTAGCTGAAGATCATGC	0.637		NaN											0	0	0	1	0	31	4				
TEX10	54881	broad.mit.edu	37	9	103090142	103090142	+	Silent	SNP	G	G	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:103090142G>T	uc004bas.2	-	8	1943	c.1728C>A	c.(1726-1728)ATC>ATA	p.I576I	TEX10_uc011lvf.1_Silent_p.I415I|TEX10_uc011lvg.1_Silent_p.I579I	NM_017746	NP_060216	Q9NXF1	TEX10_HUMAN	testis expressed 10 isoform 1	576						integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		CGGTATGAATGATATCGATAA	0.418		NaN											1	0	3.01185e-09	1	3.194e-09	26	8				
OR13C3	138803	broad.mit.edu	37	9	107298330	107298330	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:107298330G>C	uc004bcb.1	-	1	765	c.765C>G	c.(763-765)ATC>ATG	p.I255M		NM_001001961	NP_001001961	Q8NGS6	O13C3_HUMAN	olfactory receptor, family 13, subfamily C,	255	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1						TCATTTGCAAGATGGTGTAGA	0.413		NaN											0	0	0	1	0	57	9				
OR13C3	138803	broad.mit.edu	37	9	107298688	107298688	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:107298688G>A	uc004bcb.1	-	1	407	c.407C>T	c.(406-408)GCA>GTA	p.A136V		NM_001001961	NP_001001961	Q8NGS6	O13C3_HUMAN	olfactory receptor, family 13, subfamily C,	136	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1						TGACCCCATTGCAAACCCAAA	0.453		NaN											0	0	0	1	0	53	87				
C9orf152	401546	broad.mit.edu	37	9	112963584	112963584	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:112963584C>G	uc011lwk.1	-	2	918	c.364G>C	c.(364-366)GAG>CAG	p.E122Q		NM_001012993	NP_001013011	Q5JTZ5	CI152_HUMAN	hypothetical protein LOC401546	122											0						CAATGCATCTCCAGGTGCGTG	0.587		NaN											0	0	0	1	0	48	47				
C9orf84	158401	broad.mit.edu	37	9	114510461	114510461	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:114510461C>T	uc004bfr.2	-	7	824	c.689G>A	c.(688-690)GGA>GAA	p.G230E	C9orf84_uc011lwt.1_RNA|C9orf84_uc004bfs.1_Missense_Mutation_p.G294E|C9orf84_uc004bfq.2_Missense_Mutation_p.G191E|C9orf84_uc010mug.2_Missense_Mutation_p.G176E	NM_173521	NP_775792	Q5VXU9	CI084_HUMAN	hypothetical protein LOC158401 isoform 1	230										ovary(2)	2						ATCCTCAATTCCATGCTTGTT	0.353		NaN											0	0	0	1	0	19	36				
ODF2	4957	broad.mit.edu	37	9	131256844	131256844	+	Missense_Mutation	SNP	T	T	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:131256844T>A	uc011mbd.1	+	17	2119	c.1808T>A	c.(1807-1809)CTG>CAG	p.L603Q	ODF2_uc011maz.1_Missense_Mutation_p.L603Q|ODF2_uc011mbc.1_Missense_Mutation_p.L522Q|ODF2_uc004bva.2_Missense_Mutation_p.L556Q|ODF2_uc004bvb.2_Missense_Mutation_p.L579Q|ODF2_uc011mbe.1_Missense_Mutation_p.L598Q|ODF2_uc004bvc.2_Missense_Mutation_p.L579Q|ODF2_uc011mbf.1_Missense_Mutation_p.L584Q|ODF2_uc004bvd.3_Missense_Mutation_p.L603Q|ODF2_uc004bve.2_Missense_Mutation_p.L584Q|ODF2_uc004bvh.2_5'Flank	NM_002540	NP_002531	Q5BJF6	ODFP2_HUMAN	outer dense fiber of sperm tails 2 isoform 1	603	Potential.				cell differentiation|G2/M transition of mitotic cell cycle|multicellular organismal development|spermatogenesis	centriole|cilium|cytosol|microtubule|spindle pole	protein binding|structural molecule activity			ovary(1)	1						CCTGACATCCTGAAGATCACG	0.562		NaN											0	0	0	1	0	10	21				
SPTAN1	6709	broad.mit.edu	37	9	131341958	131341958	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:131341958G>A	uc004bvl.3	+	10	1377	c.1264G>A	c.(1264-1266)GAA>AAA	p.E422K	SPTAN1_uc011mbg.1_Missense_Mutation_p.E422K|SPTAN1_uc011mbh.1_Missense_Mutation_p.E434K|SPTAN1_uc004bvm.3_Missense_Mutation_p.E422K|SPTAN1_uc004bvn.3_Missense_Mutation_p.E422K	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	422	Spectrin 5.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						ATCTGCAGATGAATCTGGACA	0.428		NaN											0	0	0	1	0	34	2				
FCN1	2219	broad.mit.edu	37	9	137803022	137803022	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:137803022C>G	uc004cfi.2	-	8	782	c.690G>C	c.(688-690)GAG>GAC	p.E230D		NM_002003	NP_001994	O00602	FCN1_HUMAN	ficolin 1 precursor	230	Fibrinogen C-terminal.				opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding			large_intestine(1)|ovary(1)	2		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)		GCTTGTACTTCTCTGCCTCGT	0.552		NaN											0	0	0	1	0	72	173				
KIAA0649	9858	broad.mit.edu	37	9	138378236	138378236	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:138378236G>A	uc004cfr.1	+	4	2429	c.1880G>A	c.(1879-1881)AGA>AAA	p.R627K		NM_014811	NP_055626	Q5T8A7	K0649_HUMAN	1A6/DRIM (down-regulated in metastasis)	627						nucleolus	protein binding			ovary(2)|central_nervous_system(1)	3				OV - Ovarian serous cystadenocarcinoma(145;6.91e-08)|Epithelial(140;4.69e-07)|all cancers(34;9.33e-06)		AGCCAGGGGAGAGCTGAGCCC	0.662		NaN											0	0	0	1	0	4	41				
SNAPC4	6621	broad.mit.edu	37	9	139273711	139273711	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:139273711C>G	uc004chh.2	-	21	2577	c.2568G>C	c.(2566-2568)AAG>AAC	p.K856N		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,	856					snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		GGCTGGCACTCTTTGAGGCTT	0.662		NaN											0	0	0	1	0	14	4				
NOTCH1	4851	broad.mit.edu	37	9	139405623	139405623	+	Silent	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:139405623G>C	uc004chz.2	-	16	2568	c.2568C>G	c.(2566-2568)GTC>GTG	p.V856V	NOTCH1_uc004cia.1_Silent_p.V86V	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	856	Extracellular (Potential).|EGF-like 22.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CCGTGGGGCAGACACAGGAGA	0.677		NaN	T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			0	0	0	1	0	17	69				
COBRA1	25920	broad.mit.edu	37	9	140166654	140166654	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:140166654C>T	uc004cmm.3	+	11	1670	c.1467C>T	c.(1465-1467)TTC>TTT	p.F489F		NM_015456	NP_056271	Q8WX92	NELFB_HUMAN	cofactor of BRCA1	489					negative regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription elongation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleoplasm	protein binding				0	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.137)	OV - Ovarian serous cystadenocarcinoma(145;9.42e-05)|Epithelial(140;0.000766)		TCGATGGCTTCTTCCTCACCG	0.617		NaN											0	0	0	1	0	58	26				
EHMT1	79813	broad.mit.edu	37	9	140657159	140657159	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr9:140657159G>C	uc011mfc.1	+	10	1571	c.1534G>C	c.(1534-1536)GAC>CAC	p.D512H	EHMT1_uc004coa.2_Missense_Mutation_p.D512H|EHMT1_uc004cob.1_Missense_Mutation_p.D481H|FLJ40292_uc010nco.2_5'Flank	NM_024757	NP_079033	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	512					DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|pancreas(1)	3	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		GCTGGAGACAGACGGCCTCCA	0.537		NaN											0	0	0	1	0	6	31				
MXRA5	25878	broad.mit.edu	37	X	3229461	3229461	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:3229461C>T	uc004crg.3	-	7	6940	c.6783G>A	c.(6781-6783)CTG>CTA	p.L2261L		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	2261	Ig-like C2-type 7.					extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				AGTCCACTTTCAGGTCACCCC	0.557		NaN											0	0	0	1	0	35	35				
ARHGAP6	395	broad.mit.edu	37	X	11197423	11197423	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:11197423G>A	uc004cup.1	-	7	2352	c.1479C>T	c.(1477-1479)CTC>CTT	p.L493L	ARHGAP6_uc004cuo.1_RNA|ARHGAP6_uc004cur.1_Silent_p.L493L|ARHGAP6_uc004cum.1_Silent_p.L290L|ARHGAP6_uc004cun.1_Silent_p.L313L|ARHGAP6_uc010neb.1_Silent_p.L315L|ARHGAP6_uc011mif.1_Silent_p.L290L	NM_013427	NP_038286	O43182	RHG06_HUMAN	Rho GTPase activating protein 6 isoform 1	493	Rho-GAP.				actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2						ATTACGCACAGAGAGTGTTGA	0.453		NaN											0	0	0	1	0	54	4				
DDX3X	1654	broad.mit.edu	37	X	41203072	41203072	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:41203072G>A	uc004dfe.2	+	8	1617	c.762G>A	c.(760-762)ATG>ATA	p.M254I	DDX3X_uc010nhf.1_Missense_Mutation_p.M238I|DDX3X_uc004dff.2_Missense_Mutation_p.M254I|DDX3X_uc011mkq.1_Missense_Mutation_p.M238I|DDX3X_uc011mkr.1_Missense_Mutation_p.M254I|DDX3X_uc011mks.1_Intron|DDX3X_uc004dfg.2_RNA|DDX3X_uc011mkt.1_Intron	NM_001356	NP_001347	O00571	DDX3X_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3	254	Helicase ATP-binding.				interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6						TGAGGGCCATGAAGGTAGATG	0.398		NaN								HNSCC(61;0.18)			0	0	0	1	0	20	20				
WDR45	11152	broad.mit.edu	37	X	48932868	48932868	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:48932868G>A	uc004dmk.1	-	10	1072	c.900C>T	c.(898-900)TTC>TTT	p.F300F	PRAF2_uc004dmh.2_5'Flank|PRAF2_uc004dmi.2_5'Flank|PRAF2_uc011mmt.1_Intron|WDR45_uc004dmj.1_Silent_p.F261F|WDR45_uc004dml.1_Silent_p.F301F|WDR45_uc004dmm.1_Silent_p.F265F|WDR45_uc010nim.1_Intron|WDR45_uc004dmn.1_Silent_p.F191F|WDR45_uc004dmo.1_Silent_p.F323F|WDR45_uc004dmp.1_Silent_p.F301F	NM_001029896	NP_001025067	Q9Y484	WIPI4_HUMAN	WD repeat domain 45 isoform 2	300				FTV -> YTA (in Ref. 1; AAV80764).	autophagy|response to starvation	organelle membrane	phosphatidylinositol-3,5-bisphosphate binding			ovary(1)	1						CAGGCACAGTGAAGCTCGCCA	0.597		NaN											0	0	0	1	0	6	12				
CCDC22	28952	broad.mit.edu	37	X	49106025	49106025	+	Missense_Mutation	SNP	A	A	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:49106025A>T	uc004dnd.1	+	15	1847	c.1691A>T	c.(1690-1692)CAC>CTC	p.H564L	CCDC22_uc004dnc.1_RNA	NM_014008	NP_054727	O60826	CCD22_HUMAN	coiled-coil domain containing 22	564										central_nervous_system(1)	1						GCTGCTCTGCACGAGGTGAGG	0.597		NaN											0	0	0	1	0	10	11				
CCNB3	85417	broad.mit.edu	37	X	50053381	50053381	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:50053381G>A	uc004dox.3	+	6	2510	c.2212G>A	c.(2212-2214)GAG>AAG	p.E738K	CCNB3_uc004doy.2_Missense_Mutation_p.E738K|CCNB3_uc004doz.2_Intron|CCNB3_uc010njq.2_Intron	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	738					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					GCTTTCTGCTGAGGCAGCCAC	0.428		NaN											0	0	0	1	0	29	1				
SHROOM4	57477	broad.mit.edu	37	X	50377284	50377284	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:50377284G>A	uc004dpe.2	-	4	1815	c.1789C>T	c.(1789-1791)CAG>TAG	p.Q597*	SHROOM4_uc004dpd.3_RNA|SHROOM4_uc004dpf.1_Nonsense_Mutation_p.Q481*	NM_020717	NP_065768	Q9ULL8	SHRM4_HUMAN	shroom family member 4	597					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)					TTCCTCCTCTGAATTTCATTA	0.582		NaN											0	0	0	1	0	27	1				
SHROOM4	57477	broad.mit.edu	37	X	50377642	50377642	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:50377642G>A	uc004dpe.2	-	4	1457	c.1431C>T	c.(1429-1431)ACC>ACT	p.T477T	SHROOM4_uc004dpd.3_RNA|SHROOM4_uc004dpf.1_Silent_p.T361T	NM_020717	NP_065768	Q9ULL8	SHRM4_HUMAN	shroom family member 4	477					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)					CCACTTGTCTGGTCTTTCTTT	0.527		NaN											0	0	0	1	0	73	7				
HUWE1	10075	broad.mit.edu	37	X	53575134	53575134	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:53575134G>A	uc004dsp.2	-	68	10538	c.10136C>T	c.(10135-10137)TCC>TTC	p.S3379F	HUWE1_uc004dsn.2_Missense_Mutation_p.S2187F	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	3379					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						ACTGCTGGAGGACTGTGAGGA	0.507		NaN											0	0	0	1	0	5	3				
MAGEE1	57692	broad.mit.edu	37	X	75649791	75649791	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:75649791C>A	uc004ecm.1	+	1	1675	c.1468C>A	c.(1468-1470)CCT>ACT	p.P490T		NM_020932	NP_065983	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	490						dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|ovary(1)|pancreas(1)|skin(1)	6						GCCCCAAGACCCTATGGAACA	0.483		NaN											1	0	2.17888e-05	1	2.24966e-05	9	26				
RPS6KA6	27330	broad.mit.edu	37	X	83375020	83375020	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:83375020T>C	uc004eej.1	-	9	739	c.662A>G	c.(661-663)AAG>AGG	p.K221R	RPS6KA6_uc011mqt.1_Missense_Mutation_p.K221R|RPS6KA6_uc011mqu.1_Missense_Mutation_p.K118R|RPS6KA6_uc010nmo.1_RNA	NM_014496	NP_055311	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase polypeptide 6	221	Protein kinase 1.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|central_nervous_system(1)|skin(1)	8						TACTGACTCCTTGCTGAGTCC	0.343		NaN											0	0	0	1	0	50	10				
MID2	11043	broad.mit.edu	37	X	107084381	107084381	+	Nonsense_Mutation	SNP	T	T	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:107084381T>A	uc004enl.2	+	2	1059	c.486T>A	c.(484-486)TGT>TGA	p.C162*	MID2_uc004enk.2_Nonsense_Mutation_p.C162*	NM_012216	NP_036348	Q9UJV3	TRIM1_HUMAN	midline 2 isoform 1	162	B box-type 1; degenerate.					centrosome|microtubule	ligase activity|zinc ion binding			ovary(1)	1						TCTCCTACTGTGACCGTTGCC	0.572		NaN											0	0	0	1	0	7	23				
AMOT	154796	broad.mit.edu	37	X	112033888	112033888	+	Silent	SNP	C	C	T			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:112033888C>T	uc004epr.2	-	7	2049	c.2049G>A	c.(2047-2049)CAG>CAA	p.Q683Q	AMOT_uc004eps.2_Silent_p.Q274Q	NM_001113490	NP_001106962	Q4VCS5	AMOT_HUMAN	angiomotin isoform 1	683	Potential.				actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction|tight junction	angiostatin binding|protein binding|receptor activity			ovary(1)	1						CCAAATATTTCTGCTCCCACT	0.493		NaN											0	0	0	1	0	34	103				
ODZ1	10178	broad.mit.edu	37	X	123518337	123518337	+	Silent	SNP	T	T	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:123518337T>A	uc004euj.2	-	29	6487	c.6423A>T	c.(6421-6423)GGA>GGT	p.G2141G	ODZ1_uc011muj.1_Silent_p.G2147G|ODZ1_uc010nqy.2_Silent_p.G2148G	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	2141	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TGGCATCTACTCCTACCCTTA	0.398		NaN											0	0	0	1	0	38	153				
ODZ1	10178	broad.mit.edu	37	X	123680941	123680941	+	Splice_Site	SNP	C	C	G			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:123680941C>G	uc004euj.2	-	15	2499	c.2435_splice	c.e15-1	p.D812_splice	ODZ1_uc011muj.1_Splice_Site_p.D811_splice|ODZ1_uc010nqy.2_Splice_Site_p.D812_splice	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3						immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						GTTAAACCATCTGGAAATAAA	0.348		NaN											0	0	0	1	0	37	3				
BCORL1	63035	broad.mit.edu	37	X	129149535	129149535	+	Silent	SNP	G	G	A			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:129149535G>A	uc004evb.1	+	4	2901	c.2787G>A	c.(2785-2787)CAG>CAA	p.Q929Q	BCORL1_uc010nrd.1_Silent_p.Q831Q	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	929					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						TCAGCCCTCAGACTGGGACCC	0.537		NaN											0	0	0	1	0	13	34				
GPR119	139760	broad.mit.edu	37	X	129519381	129519381	+	Missense_Mutation	SNP	A	A	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:129519381A>C	uc011muv.1	-	1	41	c.41T>G	c.(40-42)CTG>CGG	p.L14R		NM_178471	NP_848566	Q8TDV5	GP119_HUMAN	G protein-coupled receptor 119	14	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	lipid binding			ovary(2)	2						GAGGGAGGCCAGGACAGCAAG	0.483		NaN											0	0	0	1	0	68	136				
DKC1	1736	broad.mit.edu	37	X	153995277	153995277	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:153995277G>C	uc004fmm.2	+	6	664	c.454G>C	c.(454-456)GAG>CAG	p.E152Q	DKC1_uc010nvf.2_Missense_Mutation_p.E152Q|SNORA36A_uc004fmn.2_5'Flank	NM_001363	NP_001354	O60832	DKC1_HUMAN	dyskerin isoform 1	152					cell proliferation|pseudouridine synthesis|rRNA processing|telomere maintenance via telomerase	Cajal body|nucleolus|telomerase holoenzyme complex	protein binding|pseudouridine synthase activity|RNA binding|telomerase activity				0	all_cancers(53;8.15e-17)|all_epithelial(53;1.1e-10)|all_lung(58;6.63e-07)|Lung NSC(58;2.08e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TTCAGGCAAAGAGTATGTGGG	0.463		NaN							Congenital_Dyskeratosis				0	0	0	1	0	10	49				
MUC5B	727897	broad.mit.edu	37	11	1278842	1278866	+	Frame_Shift_Del	DEL	GTGACGCCCAGGGTCAGCCCCCGCC	GTGACGCCCAGGGTCAGCCCCCGCC	-			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr11:1278842_1278866delGTGACGCCCAGGGTCAGCCCCCGCC	uc009ycr.1	+	63	17489_17513	c.17363_17387delGTGACGCCCAGGGTCAGCCCCCGCC	c.(17362-17388)TGTGACGCCCAGGGTCAGCCCCCGCCGfs	p.C5788fs	MUC5B_uc001ltb.2_Frame_Shift_Del_p.C5454fs	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	5451_5459	VWFC 2.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		CCCCTGCCCTGTGACGCCCAGGGTCAGCCCCCGCCGTGCAACCGT	0.684		NaN											NaN	NaN	NaN	NaN	NaN	7	9	---		---	---
AKAP6	9472	broad.mit.edu	37	14	33004894	33004908	+	In_Frame_Del	DEL	GCTTCGAGTCTCAGT	GCTTCGAGTCTCAGT	-			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr14:33004894_33004908delGCTTCGAGTCTCAGT	uc001wrq.2	+	3	629_643	c.459_473delGCTTCGAGTCTCAGT	c.(457-474)CAGCTTCGAGTCTCAGTG>CAG	p.LRVSV154del	AKAP6_uc010aml.2_In_Frame_Del_p.LRVSV151del	NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	154_158					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		TCTGGCACCAGCTTCGAGTCTCAGTGCTGGTTCTG	0.521		NaN											NaN	NaN	NaN	NaN	NaN	18	40	---		---	---
DMXL2	23312	broad.mit.edu	37	15	51778370	51778370	+	Frame_Shift_Del	DEL	A	A	-			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr15:51778370delA	uc002abf.2	-	23	5607	c.5382delT	c.(5380-5382)GATfs	p.D1794fs	DMXL2_uc010ufy.1_Frame_Shift_Del_p.D1794fs|DMXL2_uc010bfa.2_Frame_Shift_Del_p.D1158fs	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	1794						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		GCAGGAAAGGATCAGGATGTA	0.408		NaN											NaN	NaN	NaN	NaN	NaN	25	38	---		---	---
TRIM16	10626	broad.mit.edu	37	17	15501958	15501975	+	Splice_Site	DEL	ATCCCAGTATCTGCAGGA	ATCCCAGTATCTGCAGGA	-			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:15501958_15501975delATCCCAGTATCTGCAGGA	uc002gor.1	-	14	2701	c.2364_splice	c.e14-1	p.R788_splice	CDRT1_uc010vvy.1_5'UTR|CDRT1_uc010vvz.1_5'UTR|CDRT1_uc002gov.3_Splice_Site_p.R478_splice|CDRT1_uc002gou.2_Splice_Site_p.R86_splice|CDRT1_uc010cos.1_5'UTR			O95361	TRI16_HUMAN	SubName: Full=Putative uncharacterized protein; Flags: Fragment;						histone H3 acetylation|histone H4 acetylation|positive regulation of interleukin-1 beta secretion|positive regulation of keratinocyte differentiation|positive regulation of retinoic acid receptor signaling pathway|positive regulation of transcription, DNA-dependent|response to growth hormone stimulus|response to organophosphorus|response to retinoic acid	cytoplasm|plasma membrane|PML body	DNA binding|interleukin-1 binding|NACHT domain binding|zinc ion binding			ovary(2)|skin(1)	3				UCEC - Uterine corpus endometrioid carcinoma (92;0.0839)|Epithelial(1;8.4e-29)|all cancers(1;3.06e-28)|Colorectal(1;1.57e-19)|OV - Ovarian serous cystadenocarcinoma(1;6.1e-17)|COAD - Colon adenocarcinoma(1;3.38e-12)|READ - Rectum adenocarcinoma(2;1.46e-05)|BRCA - Breast invasive adenocarcinoma(8;0.0559)		CACTTTTCAGATCCCAGTATCTGCAGGAATCAGGCCAA	0.472		NaN											NaN	NaN	NaN	NaN	NaN	7	13	---		---	---
NF1	4763	broad.mit.edu	37	17	29592283	29592283	+	Frame_Shift_Del	DEL	G	G	-			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08			G	-	G	G		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:29592283delG	uc002hgg.2	+	36	5094	c.4761delG	c.(4759-4761)TTGfs	p.L1587fs	NF1_uc002hgh.2_Frame_Shift_Del_p.L1566fs|NF1_uc002hgi.1_Frame_Shift_Del_p.L599fs|NF1_uc010cso.2_5'UTR	NM_001042492	NP_001035957	P21359	NF1_HUMAN	neurofibromin isoform 1	1587	CRAL-TRIO.				actin cytoskeleton organization|adrenal gland development|artery morphogenesis|camera-type eye morphogenesis|cerebral cortex development|collagen fibril organization|forebrain astrocyte development|forebrain morphogenesis|heart development|liver development|MAPKKK cascade|metanephros development|myelination in peripheral nervous system|negative regulation of cell migration|negative regulation of endothelial cell proliferation|negative regulation of MAP kinase activity|negative regulation of MAPKKK cascade|negative regulation of neuroblast proliferation|negative regulation of oligodendrocyte differentiation|negative regulation of transcription factor import into nucleus|osteoblast differentiation|phosphatidylinositol 3-kinase cascade|pigmentation|positive regulation of adenylate cyclase activity|positive regulation of neuron apoptosis|Ras protein signal transduction|regulation of blood vessel endothelial cell migration|regulation of bone resorption|response to hypoxia|smooth muscle tissue development|spinal cord development|sympathetic nervous system development|visual learning|wound healing	axon|cytoplasm|dendrite|intrinsic to internal side of plasma membrane|nucleus	protein binding|Ras GTPase activator activity	p.?(3)|p.L1587*(1)		soft_tissue(159)|central_nervous_system(56)|lung(28)|large_intestine(27)|haematopoietic_and_lymphoid_tissue(18)|ovary(18)|autonomic_ganglia(12)|breast(3)|skin(3)|stomach(2)|thyroid(1)|prostate(1)|kidney(1)|pancreas(1)	330		all_cancers(10;1.29e-12)|all_epithelial(10;0.00347)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Breast(31;0.014)|Myeloproliferative disorder(56;0.0255)|all_lung(9;0.0321)|Lung NSC(157;0.0659)		UCEC - Uterine corpus endometrioid carcinoma (4;4.38e-05)|all cancers(4;1.64e-26)|Epithelial(4;9.15e-23)|OV - Ovarian serous cystadenocarcinoma(4;3.58e-21)|GBM - Glioblastoma multiforme(4;0.00146)		TCAAGGCTTTGAAAACGTTAA	0.343		NaN	D|Mis|N|F|S|O		neurofibroma|glioma	neurofibroma|glioma			Neurofibromatosis_type_1	TCGA GBM(6;<1E-08)|TSP Lung(7;0.0071)|TCGA Ovarian(3;0.0088)			NaN	NaN	NaN	NaN	NaN	19	105	---	Valid	---	---
CDK12	51755	broad.mit.edu	37	17	37618605	37618605	+	Frame_Shift_Del	DEL	G	G	-			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:37618605delG	uc010cvv.2	+	1	867	c.281delG	c.(280-282)AGGfs	p.R94fs	CDK12_uc010wef.1_Frame_Shift_Del_p.R94fs|CDK12_uc002hrw.3_Frame_Shift_Del_p.R94fs	NM_016507	NP_057591	Q9NYV4	CDK12_HUMAN	Cdc2-related kinase, arginine/serine-rich	94					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			ovary(10)|lung(4)|breast(2)|skin(2)|large_intestine(1)	19						CTAGACCGAAGGGAGAACGAC	0.522		NaN								TCGA Ovarian(9;0.13)			NaN	NaN	NaN	NaN	NaN	10	53	---		---	---
CNP	1267	broad.mit.edu	37	17	40123969	40123969	+	Frame_Shift_Del	DEL	C	C	-			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr17:40123969delC	uc002hyl.1	+	3	880	c.736delC	c.(736-738)CCCfs	p.P246fs	CNP_uc010wfz.1_Frame_Shift_Del_p.P123fs|CNP_uc002hym.1_Frame_Shift_Del_p.P226fs|CNP_uc010wga.1_Frame_Shift_Del_p.P11fs|CNP_uc002hyn.1_Frame_Shift_Del_p.P11fs	NM_033133	NP_149124	P09543	CN37_HUMAN	2',3'-cyclic nucleotide 3' phosphodiesterase	246					cell killing|cyclic nucleotide catabolic process|RNA metabolic process|synaptic transmission	extracellular space|melanosome	2',3'-cyclic-nucleotide 3'-phosphodiesterase activity|ATP binding|protein binding				0		all_cancers(22;2.38e-06)|all_epithelial(22;6.79e-05)|Breast(137;0.000143)		UCEC - Uterine corpus endometrioid carcinoma (308;0.171)		TGGAAAGAGACCCCCAGGCGT	0.592		NaN											NaN	NaN	NaN	NaN	NaN	16	36	---		---	---
CDH4	1002	broad.mit.edu	37	20	60485588	60485606	+	Frame_Shift_Del	DEL	CAGTGGGGATCCATCCGGG	CAGTGGGGATCCATCCGGG	-	rs35293044		TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr20:60485588_60485606delCAGTGGGGATCCATCCGGG	uc002ybn.1	+	9	1313_1331	c.1299_1317delCAGTGGGGATCCATCCGGG	c.(1297-1317)ATCAGTGGGGATCCATCCGGGfs	p.I433fs	CDH4_uc002ybp.1_Frame_Shift_Del_p.I359fs	NM_001794	NP_001785	P55283	CADH4_HUMAN	cadherin 4, type 1 preproprotein	433_439	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly		calcium ion binding			lung(3)|ovary(2)|skin(1)	6			BRCA - Breast invasive adenocarcinoma(19;2.36e-08)			ACCGCATCATCAGTGGGGATCCATCCGGGCACTTCAGCG	0.603		NaN											NaN	NaN	NaN	NaN	NaN	7	73	---		---	---
RFPL2	10739	broad.mit.edu	37	22	32590428	32590434	+	Frame_Shift_Del	DEL	TCCCACC	TCCCACC	-			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr22:32590428_32590434delTCCCACC	uc003amg.3	-	3	1099_1105	c.163_169delGGTGGGA	c.(163-171)GGTGGGAATfs	p.G55fs	RFPL2_uc003ame.3_5'Flank|RFPL2_uc003amf.3_Intron|RFPL2_uc003amh.3_Intron	NM_001098527	NP_001091997	O75678	RFPL2_HUMAN	ret finger protein-like 2 isoform 2	55_57							zinc ion binding			skin(1)	1						TTGGTGAGATTCCCACCTCCCACTGGG	0.507		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---		---	---
SH3BP5	9467	broad.mit.edu	37	3	15373833	15373835	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr3:15373833_15373835delTCC	uc003bzp.1	-	1	270_272	c.81_83delGGA	c.(79-84)GAGGAA>GAA	p.27_28EE>E	SH3BP5_uc010hem.1_RNA|SH3BP5_uc003bzq.1_Intron|SH3BP5_uc003bzr.1_Intron	NM_004844	NP_004835	O60239	3BP5_HUMAN	SH3-domain binding protein 5 (BTK-associated)	27_28	Glu-rich.				intracellular signal transduction	mitochondrion	protein kinase inhibitor activity|SH3 domain binding				0						catcccctcttcctcctcctcct	0.522		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---		---	---
RFPL4B	442247	broad.mit.edu	37	6	112671551	112671561	+	Frame_Shift_Del	DEL	ACTTAGAAGAA	ACTTAGAAGAA	-			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr6:112671551_112671561delACTTAGAAGAA	uc003pvx.1	+	3	953_963	c.641_651delACTTAGAAGAA	c.(640-651)GACTTAGAAGAAfs	p.D214fs		NM_001013734	NP_001013756	Q6ZWI9	RFPLB_HUMAN	ret finger protein-like 4B	214_217	B30.2/SPRY.						zinc ion binding				0		all_cancers(87;9.44e-05)|all_hematologic(75;0.000114)|all_epithelial(87;0.00265)|Colorectal(196;0.0209)		all cancers(137;0.0202)|OV - Ovarian serous cystadenocarcinoma(136;0.0477)|Epithelial(106;0.0646)|GBM - Glioblastoma multiforme(226;0.0866)|BRCA - Breast invasive adenocarcinoma(108;0.244)		CTGGATGCTGACTTAGAAGAAATCCAGTTTT	0.455		NaN											NaN	NaN	NaN	NaN	NaN	9	32	---		---	---
CDK5	1020	broad.mit.edu	37	7	150751123	150751134	+	In_Frame_Del	DEL	GGGGTGCTGCAG	GGGGTGCTGCAG	-	rs11541602		TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr7:150751123_150751134delGGGGTGCTGCAG	uc003wir.1	-	12	902_913	c.841_852delCTGCAGCACCCC	c.(841-852)CTGCAGCACCCCdel	p.LQHP281del		NM_004935	NP_004926	Q00535	CDK5_HUMAN	cyclin-dependent kinase 5 isoform 1	281_284	Protein kinase.				activation of pro-apoptotic gene products|blood coagulation|cell division|cell proliferation|embryo development|negative regulation of transcription, DNA-dependent|positive regulation of neuron apoptosis	axon|cytosol|dendrite|growth cone|lamellipodium|membrane|neuromuscular junction|neuronal cell body	acetylcholine receptor activator activity|ATP binding|cyclin-dependent protein kinase activity|ErbB-2 class receptor binding|ErbB-3 class receptor binding|tau-protein kinase activity			lung(1)|central_nervous_system(1)	2		Breast(660;0.159)|Ovarian(593;0.182)	OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)|LUSC - Lung squamous cell carcinoma(290;0.008)|Lung(243;0.00942)|BRCA - Breast invasive adenocarcinoma(188;0.242)		CGGAGAAGTAGGGGTGCTGCAGGGCCTCTTCT	0.623		NaN											NaN	NaN	NaN	NaN	NaN	5	8	---		---	---
C8orf34	116328	broad.mit.edu	37	8	69358655	69358656	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:69358655_69358656delTG	uc010lyz.2	+	3	358_359	c.309_310delTG	c.(307-312)GCTGTGfs	p.A103fs	C8orf34_uc010lyx.1_Frame_Shift_Del_p.A103fs|C8orf34_uc010lyy.1_Frame_Shift_Del_p.A103fs|C8orf34_uc003xyb.2_Frame_Shift_Del_p.A78fs	NM_052958	NP_443190	Q49A92	CH034_HUMAN	hypothetical protein LOC116328	103_104					signal transduction		cAMP-dependent protein kinase regulator activity			large_intestine(1)	1			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			GTGACCTTGCTGTGTCTAATAT	0.337		NaN											NaN	NaN	NaN	NaN	NaN	13	59	---		---	---
YWHAZ	7534	broad.mit.edu	37	8	101936227	101936245	+	Frame_Shift_Del	DEL	TGTATGACTCTTCACTTAA	TGTATGACTCTTCACTTAA	-			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:101936227_101936245delTGTATGACTCTTCACTTAA	uc011lhe.1	-	5	793_811	c.616_634delTTAAGTGAAGAGTCATACA	c.(616-636)TTAAGTGAAGAGTCATACAAAfs	p.L206fs	YWHAZ_uc003yjv.2_Frame_Shift_Del_p.L206fs|YWHAZ_uc011lhf.1_Frame_Shift_Del_p.L206fs|YWHAZ_uc003yjw.2_Frame_Shift_Del_p.L206fs|YWHAZ_uc010mbq.2_Frame_Shift_Del_p.L129fs|YWHAZ_uc011lhg.1_Frame_Shift_Del_p.L86fs|YWHAZ_uc010mbr.2_Frame_Shift_Del_p.L206fs|YWHAZ_uc003yjx.2_Frame_Shift_Del_p.L206fs|YWHAZ_uc003yjy.2_Frame_Shift_Del_p.L206fs	NM_001135702	NP_001129174	P63104	1433Z_HUMAN	tyrosine 3/tryptophan 5 -monooxygenase	206_212					anti-apoptosis|mRNA metabolic process|platelet activation|signal transduction	cytosol|melanosome	transcription factor binding				0	all_cancers(14;7.43e-06)|all_epithelial(15;2.77e-08)|Lung NSC(17;6.08e-05)|all_lung(17;0.000197)		Epithelial(11;2.79e-11)|all cancers(13;5.45e-09)|OV - Ovarian serous cystadenocarcinoma(57;4.75e-05)		Ginkgo biloba(DB01381)	GTGCTGTCTTTGTATGACTCTTCACTTAATGTATCAAGT	0.333		NaN											NaN	NaN	NaN	NaN	NaN	16	155	---		---	---
MTBP	27085	broad.mit.edu	37	8	121483136	121483144	+	In_Frame_Del	DEL	AATGGAAGG	AATGGAAGG	-			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chr8:121483136_121483144delAATGGAAGG	uc003ypc.1	+	11	1169_1177	c.1124_1132delAATGGAAGG	c.(1123-1134)AAATGGAAGGAA>AAA	p.WKE376del	MTBP_uc011lie.1_RNA	NM_022045	NP_071328	Q96DY7	MTBP_HUMAN	Mdm2, transformed 3T3 cell double minute 2, p53	376_378					cell cycle arrest					skin(2)|ovary(1)	3	Lung NSC(37;5.68e-08)|Ovarian(258;0.00769)|all_neural(195;0.0804)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00503)			AGTTCAAGAAAATGGAAGGAATATATAGC	0.33		NaN											NaN	NaN	NaN	NaN	NaN	9	125	---		---	---
KLHL34	257240	broad.mit.edu	37	X	21674920	21674922	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-G2-A3VY-01A-11D-A22Z-08	TCGA-G2-A3VY-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	03337bf0-498e-440a-8159-42a376fa73aa	9ac3221e-f850-465c-953b-2f735aa8d368	g.chrX:21674920_21674922delCTC	uc004czz.1	-	1	1527_1529	c.985_987delGAG	c.(985-987)GAGdel	p.E329del		NM_153270	NP_695002	Q8N239	KLH34_HUMAN	kelch-like 34	329	Kelch 1.|Glu-rich.									ovary(1)	1						TGAGCTCCCActcctcctcctcc	0.527		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---		---	---
