Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_by_all_platform	validation_method	validation_tumor_sample
ZBTB40	9923	broad.mit.edu	37	1	22838486	22838486	+	Missense_Mutation	SNP	A	A	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr1:22838486A>T	uc001bft.2	+	12	2831	c.2320A>T	c.(2320-2322)ACC>TCC	p.T774S	ZBTB40_uc001bfu.2_Missense_Mutation_p.T774S|ZBTB40_uc009vqi.1_Missense_Mutation_p.T662S|ZBTB40_uc001bfv.1_Missense_Mutation_p.T403S	NM_001083621	NP_001077090	Q9NUA8	ZBT40_HUMAN	zinc finger and BTB domain containing 40	774					bone mineralization|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;2.86e-26)|Colorectal(126;8.55e-08)|COAD - Colon adenocarcinoma(152;4.1e-06)|GBM - Glioblastoma multiforme(114;1.39e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000712)|KIRC - Kidney renal clear cell carcinoma(1967;0.00374)|STAD - Stomach adenocarcinoma(196;0.00645)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.216)		GTGCAGTGAGACCAAGGATTC	0.537		NaN											0	0	0	0.003954	0	21	21				
OSCP1	127700	broad.mit.edu	37	1	36886081	36886081	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr1:36886081C>G	uc001cap.2	-	9	1067	c.985G>C	c.(985-987)GAG>CAG	p.E329Q	OSCP1_uc001caq.2_Missense_Mutation_p.E319Q	NM_145047	NP_659484	Q8WVF1	OSCP1_HUMAN	oxidored-nitro domain-containing protein isoform	329					transport	basal plasma membrane				ovary(2)|central_nervous_system(1)|pancreas(1)	4						acatactcctcttcttcaTCG	0.249		NaN									OREG0013368	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00361	0	51	197				
ST6GALNAC3	256435	broad.mit.edu	37	1	76877711	76877711	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr1:76877711G>A	uc001dhh.2	+	3	395	c.232G>A	c.(232-234)GAC>AAC	p.D78N	ST6GALNAC3_uc001dhg.3_Missense_Mutation_p.D78N|ST6GALNAC3_uc010orh.1_Missense_Mutation_p.D13N	NM_152996	NP_694541	Q8NDV1	SIA7C_HUMAN	sialyltransferase 7C isoform 1	78	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity			ovary(3)|skin(2)	5						ACTGGACTGTGACCTTTGTGC	0.413		NaN											0	0	0	0.00361	0	47	49				
DPH5	51611	broad.mit.edu	37	1	101490988	101490988	+	Silent	SNP	G	G	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr1:101490988G>A	uc001dts.2	-	2	159	c.12C>T	c.(10-12)CTC>CTT	p.L4L	DPH5_uc001dtr.2_Silent_p.L4L|DPH5_uc001dtq.2_RNA|DPH5_uc001dtt.2_Silent_p.L4L|DPH5_uc001dtu.2_RNA|DPH5_uc001dtv.2_RNA|DPH5_uc001dtw.2_RNA|DPH5_uc001dtx.2_Silent_p.L4L|DPH5_uc001dty.2_5'UTR|DPH5_uc001dtz.2_RNA|uc001dua.2_5'Flank|uc001dub.2_5'Flank	NM_015958	NP_057042	Q9H2P9	DPH5_HUMAN	diphthine synthase isoform a	4					peptidyl-diphthamide biosynthetic process from peptidyl-histidine		diphthine synthase activity				0		all_epithelial(167;3.1e-06)|all_lung(203;0.000414)|Lung NSC(277;0.000946)		Epithelial(280;0.0385)|all cancers(265;0.043)|COAD - Colon adenocarcinoma(174;0.151)|Colorectal(144;0.173)|Lung(183;0.198)		CCAACCCGATGAGATAAAGCA	0.488		NaN											0	0	0	0.004007	0	15	45				
POLR3C	10623	broad.mit.edu	37	1	145601614	145601614	+	Silent	SNP	G	G	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr1:145601614G>A	uc001eoh.2	-	7	953	c.792C>T	c.(790-792)AGC>AGT	p.S264S	NBPF10_uc001emp.3_Intron|POLR3C_uc001eog.2_Silent_p.S277S|POLR3C_uc001eoi.2_RNA|POLR3C_uc009wix.2_Silent_p.S264S	NM_006468	NP_006459	Q9BUI4	RPC3_HUMAN	polymerase (RNA) III (DNA directed) polypeptide	264					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|regulation of transcription from RNA polymerase III promoter|response to virus	DNA-directed RNA polymerase III complex	DNA binding|DNA-directed RNA polymerase activity			ovary(1)	1	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)		Epithelial(2;7.55e-13)			GCACAATCTCGCTGCTTGTCT	0.453		NaN											0	0	0	0.001984	0	6	34				
RPRD2	23248	broad.mit.edu	37	1	150444932	150444932	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr1:150444932C>T	uc009wlr.2	+	11	3709	c.3508C>T	c.(3508-3510)CGG>TGG	p.R1170W	RPRD2_uc010pcc.1_3'UTR|RPRD2_uc001eup.3_Missense_Mutation_p.R1144W	NM_015203	NP_056018	Q5VT52	RPRD2_HUMAN	Regulation of nuclear pre-mRNA domain containing	1170							protein binding			ovary(1)	1						ATACAAGGAACGGGCACCTCA	0.532		NaN											0	0	0	0.00499	0	15	60				
ATP8B2	57198	broad.mit.edu	37	1	154320946	154320946	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr1:154320946G>A	uc001fex.2	+	27	3325	c.3325G>A	c.(3325-3327)GTC>ATC	p.V1109I		NM_020452	NP_065185	P98198	AT8B2_HUMAN	ATPase, class I, type 8B, member 2 isoform a	1095	Helical; (Potential).				ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(1)|skin(1)	2	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CACCACAGTCGTCTGCATCAT	0.607		NaN											0	0	0	0.010729	0	11	31				
SPTA1	6708	broad.mit.edu	37	1	158650498	158650498	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr1:158650498C>G	uc001fst.1	-	5	752	c.553G>C	c.(553-555)GAG>CAG	p.E185Q		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	185	Spectrin 3.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					TCACCTAGCTCCACTGATGTC	0.448		NaN											0	0	0	0.005524	0	33	58				
KIFAP3	22920	broad.mit.edu	37	1	169923248	169923248	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr1:169923248C>T	uc001ggv.2	-	19	2448	c.2177G>A	c.(2176-2178)GGA>GAA	p.G726E	KIFAP3_uc010plx.1_Missense_Mutation_p.G428E	NM_014970	NP_055785	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	726					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					GGCAATTAATCCATCTAGAAA	0.343		NaN											0	0	0	0.007291	0	30	96				
CFHR4	10877	broad.mit.edu	37	1	196887480	196887480	+	Missense_Mutation	SNP	C	C	G	rs80010185	by1000genomes	TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr1:196887480C>G	uc001gto.2	+	6	1009	c.940C>G	c.(940-942)CTA>GTA	p.L314V	CFHR4_uc009wyy.2_Missense_Mutation_p.L560V|CFHR4_uc001gtp.2_Missense_Mutation_p.L561V	NM_006684	NP_006675	Q92496	FHR4_HUMAN	complement factor H-related 4 precursor	314	Sushi 5.					extracellular region	lipid transporter activity			ovary(1)|pancreas(1)|skin(1)	3						TACATCAGTTCTATCATTTCA	0.363		NaN											0	0	0	0.00874	0	33	241				
CFHR2	3080	broad.mit.edu	37	1	196918666	196918666	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr1:196918666C>T	uc001gtq.1	+	2	217	c.140C>T	c.(139-141)ACA>ATA	p.T47I	CFHR2_uc001gtr.1_Intron	NM_005666	NP_005657	P36980	FHR2_HUMAN	H factor (complement)-like 3 precursor	47	Sushi 1.					extracellular region				skin(2)|ovary(1)	3						CAAGTTCCTACAGGGGAAGTT	0.358		NaN											0	0	0	0.008291	0	11	70				
TMEM206	55248	broad.mit.edu	37	1	212553312	212553312	+	Missense_Mutation	SNP	C	C	T	rs141387916		TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr1:212553312C>T	uc001hjc.3	-	5	731	c.563G>A	c.(562-564)CGC>CAC	p.R188H	TMEM206_uc010pte.1_Missense_Mutation_p.R249H	NM_018252	NP_060722	Q9H813	TM206_HUMAN	transmembrane protein 206	188	Extracellular (Potential).					integral to membrane				breast(1)	1				all cancers(67;0.012)|OV - Ovarian serous cystadenocarcinoma(81;0.0121)|GBM - Glioblastoma multiforme(131;0.0377)|Epithelial(68;0.148)		CTTGTTCAGGCGGAACTGGAG	0.522		NaN											0	0	0	0.002299	0	22	90				
GNG4	2786	broad.mit.edu	37	1	235715501	235715501	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr1:235715501C>T	uc001hxe.3	-	4	590	c.136G>A	c.(136-138)GAA>AAA	p.E46K	GNG4_uc009xfz.2_Missense_Mutation_p.E46K|GNG4_uc001hxh.3_Missense_Mutation_p.E46K	NM_001098722	NP_001092192	P50150	GBG4_HUMAN	guanine nucleotide binding protein (G protein),	46					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|negative regulation of cell growth|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	heterotrimeric G-protein complex	signal transducer activity				0	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00168)|Prostate(94;0.0776)|Acute lymphoblastic leukemia(190;0.23)	OV - Ovarian serous cystadenocarcinoma(106;0.000882)			ACGTGAGCTTCACAGTAGGCC	0.542		NaN											0	0	0	0.00361	0	82	69				
CHML	1122	broad.mit.edu	37	1	241798859	241798859	+	Missense_Mutation	SNP	T	T	G			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr1:241798859T>G	uc001hzd.2	-	1	374	c.210A>C	c.(208-210)GAA>GAC	p.E70D	OPN3_uc001hza.2_Intron|OPN3_uc001hzb.2_Intron|OPN3_uc001hzc.2_Intron	NM_001821	NP_001812	P26374	RAE2_HUMAN	choroideremia-like Rab escort protein 2	70					intracellular protein transport|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity			ovary(4)|skin(2)	6	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			CAGTACTTTCTTCCCCAATGT	0.418		NaN											0	0	0	0.00361	0	60	203				
TRIM58	25893	broad.mit.edu	37	1	248023982	248023982	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr1:248023982G>A	uc001ido.2	+	2	532	c.484G>A	c.(484-486)GCC>ACC	p.A162T		NM_015431	NP_056246	Q8NG06	TRI58_HUMAN	tripartite motif-containing 58	162						intracellular	zinc ion binding			skin(3)|ovary(1)|pancreas(1)|lung(1)|central_nervous_system(1)	7	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0286)	OV - Ovarian serous cystadenocarcinoma(106;0.0319)			GACTCAGGAGGCCAACGTGGG	0.483		NaN											0	0	0	0.008291	0	9	47				
OR2T34	127068	broad.mit.edu	37	1	248737333	248737333	+	Silent	SNP	G	G	C			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr1:248737333G>C	uc001iep.1	-	1	726	c.726C>G	c.(724-726)GCC>GCG	p.A242A		NM_001001821	NP_001001821	Q8NGX1	O2T34_HUMAN	olfactory receptor, family 2, subfamily T,	242	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			AGGTGGCCAAGGCCTTCCTGC	0.567		NaN											0	0	0	0.008361	0	26	140				
HSPA14	51182	broad.mit.edu	37	10	14891755	14891755	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr10:14891755G>A	uc001inf.2	+	6	553	c.412G>A	c.(412-414)GAT>AAT	p.D138N	HSPA14_uc010qbw.1_Missense_Mutation_p.D138N	NM_016299	NP_057383	Q0VDF9	HSP7E_HUMAN	heat shock 70kDa protein 14 isoform 1	138					'de novo' cotranslational protein folding	cytosol	ATP binding|protein binding			ovary(2)|breast(2)|lung(1)	5						AGATGCAAATGATGTAGTTAT	0.338		NaN											0	0	0	0.007413	0	13	87				
OIT3	170392	broad.mit.edu	37	10	74690368	74690368	+	Silent	SNP	C	C	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr10:74690368C>T	uc001jte.1	+	8	1658	c.1440C>T	c.(1438-1440)GTC>GTT	p.V480V	OIT3_uc009xqs.1_RNA	NM_152635	NP_689848	Q8WWZ8	OIT3_HUMAN	oncoprotein-induced transcript 3 precursor	480	ZP.					nuclear envelope	calcium ion binding			ovary(2)	2	Prostate(51;0.0198)					AGGTCCCTGTCTTCAAGTTTG	0.438		NaN											0	0	0	0.00361	0	60	131				
MGEA5	10724	broad.mit.edu	37	10	103560119	103560119	+	Missense_Mutation	SNP	A	A	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr10:103560119A>T	uc001ktv.2	-	8	1518	c.1075T>A	c.(1075-1077)TTA>ATA	p.L359I	MGEA5_uc001ktu.2_5'Flank|MGEA5_uc010qqe.1_Intron|MGEA5_uc009xws.2_Intron|MGEA5_uc001ktw.2_Missense_Mutation_p.L359I|MGEA5_uc009xwt.2_Missense_Mutation_p.L122I	NM_012215	NP_036347	O60502	NCOAT_HUMAN	meningioma expressed antigen 5 (hyaluronidase)	359					glycoprotein catabolic process	cytoplasm|nucleus	histone acetyltransferase activity|hyalurononglucosaminidase activity			ovary(2)|skin(1)	3		Colorectal(252;0.207)		Epithelial(162;4.67e-09)|all cancers(201;2.54e-07)		TCATTTTCTAATTTTATCTGG	0.343		NaN											0	0	0	0.010504	0	19	45				
DOCK1	1793	broad.mit.edu	37	10	128925983	128925983	+	Silent	SNP	C	C	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr10:128925983C>T	uc001ljt.2	+	27	2803	c.2739C>T	c.(2737-2739)ACC>ACT	p.T913T	DOCK1_uc010qun.1_Silent_p.T934T	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	913					apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		TTCTCCGGACCGTGAACCGAA	0.483		NaN											0	0	0	0.001984	0	4	68				
EXT2	2132	broad.mit.edu	37	11	44146519	44146519	+	Nonsense_Mutation	SNP	C	C	G			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr11:44146519C>G	uc001mxz.2	+	5	1258	c.924C>G	c.(922-924)TAC>TAG	p.Y308*	EXT2_uc010rfo.1_Nonsense_Mutation_p.Y336*|EXT2_uc001mxy.2_Nonsense_Mutation_p.Y321*|EXT2_uc009ykt.2_Nonsense_Mutation_p.Y308*|EXT2_uc001mya.2_Nonsense_Mutation_p.Y341*	NM_207122	NP_997005	Q93063	EXT2_HUMAN	exostosin 2 isoform 2	308	Lumenal (Potential).				glycosaminoglycan biosynthetic process|heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|ossification|signal transduction	Golgi membrane|integral to membrane|intrinsic to endoplasmic reticulum membrane	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|heparan sulfate N-acetylglucosaminyltransferase activity|N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity|protein heterodimerization activity			lung(2)|breast(2)|skin(1)	5						TCTTCGATTACCCACAGGTGC	0.488		NaN	Mis|N|F|S			exostoses|osteosarcoma			Hereditary_Multiple_Exostoses				0	0	0	0.007413	0	17	38				
OR4C46	119749	broad.mit.edu	37	11	51516060	51516060	+	Missense_Mutation	SNP	C	C	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr11:51516060C>A	uc010ric.1	+	1	779	c.779C>A	c.(778-780)GCA>GAA	p.A260E		NM_001004703	NP_001004703	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C,	260	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						ATGAGACCTGCAGCTACTTTA	0.423		NaN											1	0	3.17567e-06	0.008361	3.27979e-06	19	49				
PLCB3	5331	broad.mit.edu	37	11	64029989	64029989	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr11:64029989G>A	uc001nzb.2	+	18	2149	c.2149G>A	c.(2149-2151)GAG>AAG	p.E717K	PLCB3_uc009ypg.1_Missense_Mutation_p.E717K|PLCB3_uc009yph.1_Missense_Mutation_p.E650K|PLCB3_uc009ypi.2_Missense_Mutation_p.E717K	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3	717	C2.				intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						CCCCTTCACTGAGGTCATCGT	0.647		NaN											0	0	0	0.00499	0	17	35				
SLCO1C1	53919	broad.mit.edu	37	12	20859006	20859006	+	Missense_Mutation	SNP	T	T	C			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr12:20859006T>C	uc001rej.3	+	5	750	c.395T>C	c.(394-396)TTC>TCC	p.F132S	SLCO1C1_uc010sii.1_Missense_Mutation_p.F132S|SLCO1C1_uc010sij.1_Missense_Mutation_p.F132S|SLCO1C1_uc009zip.2_Intron|SLCO1C1_uc001rei.2_Missense_Mutation_p.F132S|SLCO1C1_uc010sik.1_Missense_Mutation_p.F14S	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	132	Helical; Name=3; (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					CCTCAGTTCTTCATGGAGCAG	0.388		NaN											0	0	0	0.00361	0	53	76				
KIF21A	55605	broad.mit.edu	37	12	39730925	39730925	+	Missense_Mutation	SNP	C	C	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr12:39730925C>A	uc001rly.2	-	17	2537	c.2391G>T	c.(2389-2391)CAG>CAT	p.Q797H	KIF21A_uc001rlw.2_Missense_Mutation_p.Q114H|KIF21A_uc001rlx.2_Missense_Mutation_p.Q784H|KIF21A_uc001rlz.2_Missense_Mutation_p.Q784H|KIF21A_uc010skl.1_Missense_Mutation_p.Q784H	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	797					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				CCTTTTTCAACTGAGCAATCT	0.333		NaN											1	0	2.55716e-62	0.00361	3.06859e-62	108	45				
SFRS2IP	9169	broad.mit.edu	37	12	46318787	46318787	+	Silent	SNP	C	C	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr12:46318787C>T	uc001rox.2	-	12	3917	c.3630G>A	c.(3628-3630)CCG>CCA	p.P1210P	SFRS2IP_uc001row.2_Silent_p.P895P	NM_004719	NP_004710	Q99590	SCAFB_HUMAN	splicing factor, arginine/serine-rich 2,	1210					spliceosome assembly	nucleus	protein binding|zinc ion binding				0	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.209)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.1)		CATTCATTTGCGGTTGCATCA	0.378		NaN											0	0	0	0.012319	0	18	50				
CPSF6	11052	broad.mit.edu	37	12	69652373	69652373	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr12:69652373G>C	uc001sut.3	+	6	808	c.698G>C	c.(697-699)GGA>GCA	p.G233A	CPSF6_uc001suu.3_Missense_Mutation_p.G270A|CPSF6_uc010stk.1_5'UTR	NM_007007	NP_008938	Q16630	CPSF6_HUMAN	cleavage and polyadenylation specific factor 6,	233	Pro-rich.				mRNA polyadenylation|protein tetramerization	mRNA cleavage factor complex|paraspeckles|ribonucleoprotein complex	mRNA binding|nucleotide binding|protein binding				0	all_epithelial(5;2.47e-36)|Lung NSC(4;1.1e-32)|all_lung(4;6.26e-31)|Breast(13;1.59e-06)|Esophageal squamous(21;0.187)		Epithelial(6;4.89e-17)|BRCA - Breast invasive adenocarcinoma(5;8.5e-10)|Lung(24;6.04e-05)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.0151)|LUSC - Lung squamous cell carcinoma(43;0.171)|Kidney(9;0.241)			TTTTTAGCTGGACAGACTCCA	0.458		NaN											0	0	0	0.004656	0	22	32				
DDX55	57696	broad.mit.edu	37	12	124104079	124104079	+	Silent	SNP	C	C	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr12:124104079C>T	uc001ufi.2	+	13	1458	c.1434C>T	c.(1432-1434)GAC>GAT	p.D478D	DDX55_uc001ufh.2_3'UTR|DDX55_uc001ufk.2_Silent_p.D331D|DDX55_uc001ufl.2_Silent_p.D85D	NM_020936	NP_065987	Q8NHQ9	DDX55_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 55	478							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000142)|Epithelial(86;0.000637)|all cancers(50;0.00772)		TGCCCGTGGACGTTAATACCG	0.393		NaN											0	0	0	0.012319	0	21	61				
PCDH17	27253	broad.mit.edu	37	13	58207677	58207677	+	Missense_Mutation	SNP	G	G	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr13:58207677G>T	uc001vhq.1	+	1	1889	c.997G>T	c.(997-999)GCC>TCC	p.A333S	PCDH17_uc010aec.1_Missense_Mutation_p.A333S	NM_001040429	NP_001035519	O14917	PCD17_HUMAN	protocadherin 17 precursor	333	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			ovary(3)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	7		Lung NSC(96;0.027)|Prostate(109;0.0453)|Breast(118;0.128)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;1.06e-05)		CCCTATCCCAGCCCACTGCAA	0.627		NaN											1	0	1.64293e-13	0.00333	1.83194e-13	21	51				
GPC5	2262	broad.mit.edu	37	13	92345804	92345804	+	Missense_Mutation	SNP	A	A	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr13:92345804A>T	uc010tif.1	+	3	1055	c.689A>T	c.(688-690)AAT>ATT	p.N230I		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	230						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				CAGGCACTCAATCTGGGCATT	0.542		NaN											0	0	0	0.003954	0	27	6				
AKAP6	9472	broad.mit.edu	37	14	33291375	33291375	+	Silent	SNP	C	C	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr14:33291375C>T	uc001wrq.2	+	13	4526	c.4356C>T	c.(4354-4356)GAC>GAT	p.D1452D		NM_004274	NP_004265	Q13023	AKAP6_HUMAN	A-kinase anchor protein 6	1452					protein targeting	calcium channel complex|nuclear membrane|sarcoplasmic reticulum	protein kinase A binding|receptor binding			breast(6)|ovary(5)|lung(4)|skin(3)|large_intestine(2)|pancreas(1)	21	Breast(36;0.0388)|Prostate(35;0.15)		LUAD - Lung adenocarcinoma(48;0.00107)|Lung(238;0.00677)|STAD - Stomach adenocarcinoma(7;0.116)	GBM - Glioblastoma multiforme(265;0.019)		ATACCCCTGACTGTTTGGGAG	0.363		NaN											0	0	0	0.003954	0	24	19				
DACT1	51339	broad.mit.edu	37	14	59113073	59113073	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr14:59113073G>A	uc001xdw.2	+	4	1896	c.1732G>A	c.(1732-1734)GTC>ATC	p.V578I	DACT1_uc010trv.1_Missense_Mutation_p.V297I|DACT1_uc001xdx.2_Missense_Mutation_p.V541I|DACT1_uc010trw.1_Missense_Mutation_p.V297I	NM_016651	NP_057735	Q9NYF0	DACT1_HUMAN	dapper 1 isoform 1	578					multicellular organismal development|Wnt receptor signaling pathway	cytoplasm|nucleus				large_intestine(2)|lung(2)|ovary(1)	5						GAACATGGGCGTCGTGAAGAA	0.657		NaN											0	0	0	0.00308	0	7	19				
FMN1	342184	broad.mit.edu	37	15	33091032	33091032	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr15:33091032C>T	uc001zhf.3	-	15	3434	c.3434G>A	c.(3433-3435)CGG>CAG	p.R1145Q		NM_001103184	NP_001096654	Q68DA7	FMN1_HUMAN	formin 1	1368	FH2.				actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		TTTACTCTCCCGTTTCCAAAT	0.408		NaN											0	0	0	0.001368	0	11	14				
COX5A	9377	broad.mit.edu	37	15	75221462	75221462	+	Missense_Mutation	SNP	C	C	T	rs150174803		TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr15:75221462C>T	uc002azi.3	-	2	352	c.212G>A	c.(211-213)CGT>CAT	p.R71H		NM_004255	NP_004246	P20674	COX5A_HUMAN	cytochrome c oxidase subunit Va precursor	71					respiratory electron transport chain	mitochondrial inner membrane	cytochrome-c oxidase activity|electron carrier activity|metal ion binding				0						ATTACCTTTACGCAATTCCCA	0.413		NaN											0	0	0	0.00361	0	48	72				
CRAMP1L	57585	broad.mit.edu	37	16	1706030	1706030	+	Silent	SNP	G	G	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr16:1706030G>T	uc010uvh.1	+	9	1272	c.1272G>T	c.(1270-1272)GTG>GTT	p.V424V	CRAMP1L_uc002cmf.2_Intron	NM_020825	NP_065876	Q96RY5	CRML_HUMAN	Crm, cramped-like	424						nucleus	DNA binding				0						TCTGCACAGTGCACTGGCAGG	0.667		NaN											1	0	2.27111e-07	0.001368	2.38467e-07	11	6				
PRSS36	146547	broad.mit.edu	37	16	31150574	31150574	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr16:31150574G>A	uc002ebd.2	-	15	2512	c.2453C>T	c.(2452-2454)TCC>TTC	p.S818F	PRSS36_uc010vff.1_Missense_Mutation_p.S593F|PRSS36_uc010vfg.1_Missense_Mutation_p.S813F|PRSS36_uc010vfh.1_Missense_Mutation_p.S715F	NM_173502	NP_775773	Q5K4E3	POLS2_HUMAN	protease, serine, 36 precursor	818					proteolysis	cytoplasm|proteinaceous extracellular matrix	serine-type endopeptidase activity			ovary(1)	1						CCAGTGTGGGGAGCCACTGGG	0.632		NaN											0	0	0	0.001368	0	10	61				
CDH16	1014	broad.mit.edu	37	16	66948291	66948291	+	Missense_Mutation	SNP	A	A	G			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr16:66948291A>G	uc002eql.2	-	7	681	c.608T>C	c.(607-609)CTG>CCG	p.L203P	CDH16_uc010cdy.2_Missense_Mutation_p.L203P|CDH16_uc002eqm.2_Intron	NM_004062	NP_004053	O75309	CAD16_HUMAN	cadherin 16 precursor	203	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|upper_aerodigestive_tract(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0877)|Epithelial(162;0.203)		GGTCCTCTCCAGGGCGTGGTC	0.607		NaN											0	0	0	0.00333	0	25	7				
PKD1L2	114780	broad.mit.edu	37	16	81173269	81173269	+	Silent	SNP	G	G	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr16:81173269G>A	uc002fgh.1	-	33	5466	c.5466C>T	c.(5464-5466)ATC>ATT	p.I1822I	PKD1L2_uc002fgg.1_RNA	NM_052892	NP_443124	Q7Z442	PK1L2_HUMAN	polycystin 1-like 2 isoform a	1822	Helical; (Potential).				neuropeptide signaling pathway	integral to membrane	calcium ion binding|ion channel activity|sugar binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3						AGCCCACCAGGATGCACCACC	0.622		NaN											0	0	0	0.001168	0	5	2				
YBX2	51087	broad.mit.edu	37	17	7193038	7193038	+	Silent	SNP	G	G	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr17:7193038G>A	uc002gfq.2	-	7	912	c.855C>T	c.(853-855)TTC>TTT	p.F285F		NM_015982	NP_057066	Q9Y2T7	YBOX2_HUMAN	Y box binding protein 2	285	Pro-rich.|Required for mRNA-binding.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter|translational attenuation	cytoplasm|nucleus	DNA binding				0						GCCTGGGGCGGAAAGGCCTAA	0.672		NaN											0	0	0	0.00361	0	56	27				
TP53	7157	broad.mit.edu	37	17	7577538	7577538	+	Missense_Mutation	SNP	C	C	T	rs11540652		TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr17:7577538C>T	uc002gim.2	-	7	937	c.743G>A	c.(742-744)CGG>CAG	p.R248Q	TP53_uc002gig.1_Missense_Mutation_p.R248Q|TP53_uc002gih.2_Missense_Mutation_p.R248Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116Q|TP53_uc010cng.1_Missense_Mutation_p.R116Q|TP53_uc002gii.1_Missense_Mutation_p.R116Q|TP53_uc010cnh.1_Missense_Mutation_p.R248Q|TP53_uc010cni.1_Missense_Mutation_p.R248Q|TP53_uc002gij.2_Missense_Mutation_p.R248Q|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155Q|TP53_uc002gio.2_Missense_Mutation_p.R116Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(523)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.R155Q(4)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIN87_STOMACH)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NIHOVCAR3_OVARY)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(HCC70_BREAST)|R248Q(KYSE150_OESOPHAGUS)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PC14_LUNG)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.00361	0	51	20		Valid		
LHX1	3975	broad.mit.edu	37	17	35300098	35300098	+	Silent	SNP	G	G	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr17:35300098G>A	uc002hnh.1	+	5	1887	c.891G>A	c.(889-891)CCG>CCA	p.P297P		NM_005568	NP_005559	P48742	LHX1_HUMAN	LIM homeobox protein 1	297					cerebellar Purkinje cell differentiation|cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation|cervix development|comma-shaped body morphogenesis|dorsal/ventral pattern formation|ectoderm formation|embryonic pattern specification|embryonic retina morphogenesis in camera-type eye|embryonic viscerocranium morphogenesis|endoderm formation|forebrain regionalization|head development|motor axon guidance|negative regulation of transcription, DNA-dependent|nephric duct morphogenesis|nephron tubule epithelial cell differentiation|neuron migration|oviduct epithelium development|paramesonephric duct development|positive regulation of anterior head development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of embryonic development|positive regulation of gastrulation|positive regulation of transcription, DNA-dependent|post-embryonic development|primitive streak formation|renal vesicle morphogenesis|retina layer formation|S-shaped body morphogenesis|spinal cord association neuron differentiation|transcription from RNA polymerase II promoter|ureteric bud development|uterine epithelium development|vagina development	nucleus|protein complex	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(25;0.00607)				ACTTCTTCCCGCAAGGCCCCC	0.637		NaN											0	0	0	0.001984	0	6	5				
KCTD2	23510	broad.mit.edu	37	17	73055695	73055695	+	Nonsense_Mutation	SNP	G	G	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr17:73055695G>T	uc002jmp.2	+	4	698	c.631G>T	c.(631-633)GAA>TAA	p.E211*	KCTD2_uc010dfz.2_RNA|KCTD2_uc002jmq.2_RNA	NM_015353	NP_056168	Q14681	KCTD2_HUMAN	potassium channel tetramerisation domain	211						voltage-gated potassium channel complex	voltage-gated potassium channel activity				0	all_lung(278;0.226)					CTGGAAATTCGAACAGGTACA	0.537		NaN											1	0	3.27435e-08	0.00245	3.49634e-08	13	15				
CARD14	79092	broad.mit.edu	37	17	78169063	78169063	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr17:78169063C>T	uc002jxw.1	+	10	1625	c.1430C>T	c.(1429-1431)GCG>GTG	p.A477V	CARD14_uc002jxt.1_RNA|CARD14_uc002jxv.2_Missense_Mutation_p.A477V|CARD14_uc010wud.1_RNA|CARD14_uc002jxx.2_Missense_Mutation_p.A240V|CARD14_uc010dhu.1_Missense_Mutation_p.A275V	NM_024110	NP_077015	Q9BXL6	CAR14_HUMAN	caspase recruitment domain protein 14 isoform 1	477					activation of NF-kappaB-inducing kinase activity|positive regulation of protein phosphorylation|regulation of apoptosis	aggresome|cytoplasm|plasma membrane	CARD domain binding			ovary(4)|skin(1)	5	all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.017)|BRCA - Breast invasive adenocarcinoma(99;0.0908)			AGCAGCCCCGCGCCCCCCAGC	0.657		NaN											0	0	0	0.010729	0	10	12				
NPTX1	4884	broad.mit.edu	37	17	78444649	78444649	+	Silent	SNP	G	G	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr17:78444649G>T	uc002jyp.1	-	5	1421	c.1263C>A	c.(1261-1263)ACC>ACA	p.T421T		NM_002522	NP_002513	Q15818	NPTX1_HUMAN	neuronal pentraxin I precursor	421	Pentaxin.				central nervous system development|synaptic transmission|transport	transport vesicle	metal ion binding				0	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0232)|OV - Ovarian serous cystadenocarcinoma(97;0.0487)			AGGTCCACTTGGTGGCCCCTC	0.642		NaN											1	0	8.16277e-20	0.006999	9.35009e-20	37	19				
GNA15	2769	broad.mit.edu	37	19	3151744	3151744	+	Silent	SNP	C	C	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr19:3151744C>T	uc002lxf.2	+	4	783	c.525C>T	c.(523-525)TAC>TAT	p.Y175Y		NM_002068	NP_002059	P30679	GNA15_HUMAN	guanine nucleotide binding protein (G protein),	175					activation of phospholipase C activity by dopamine receptor signaling pathway|activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			skin(2)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.04e-05)|OV - Ovarian serous cystadenocarcinoma(105;5.08e-113)|Epithelial(107;6.19e-111)|all cancers(105;6.19e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00145)|STAD - Stomach adenocarcinoma(1328;0.184)		AGGAGGGCTACGTCCCCACAG	0.637		NaN											0	0	0	0.00361	0	41	74				
PRAM1	84106	broad.mit.edu	37	19	8563950	8563950	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr19:8563950C>T	uc002mkd.2	-	2	762	c.742G>A	c.(742-744)GAG>AAG	p.E248K	PRAM1_uc002mkc.2_Missense_Mutation_p.E248K	NM_032152	NP_115528	Q96QH2	PRAM_HUMAN	PML-RARA regulated adaptor molecule 1	296	Pro-rich.						lipid binding|protein binding				0						TGAGCGGCCTCGCTGAACTCA	0.632		NaN											0	0	0	0.001855	0	12	20				
ZNF431	170959	broad.mit.edu	37	19	21365524	21365524	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr19:21365524G>C	uc002npp.2	+	5	565	c.418G>C	c.(418-420)GAG>CAG	p.E140Q	ZNF431_uc010ecq.2_Missense_Mutation_p.E49Q|ZNF431_uc010ecr.2_Missense_Mutation_p.E141Q	NM_133473	NP_597730	Q8TF32	ZN431_HUMAN	zinc finger protein 431	140					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)	2						ATGTGAACATGAGAATTTACA	0.368		NaN											0	0	0	0.001855	0	12	34				
ZNF607	84775	broad.mit.edu	37	19	38189554	38189554	+	Missense_Mutation	SNP	G	G	C			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr19:38189554G>C	uc002ohc.1	-	5	2074	c.1478C>G	c.(1477-1479)ACT>AGT	p.T493S	ZNF607_uc002ohb.1_Missense_Mutation_p.T492S	NM_032689	NP_116078	Q96SK3	ZN607_HUMAN	zinc finger protein 607	493	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0			UCEC - Uterine corpus endometrioid carcinoma (49;0.0775)			GCGATGTATAGTGAGTTTATG	0.393		NaN											0	0	0	0.010818	0	26	99				
ZNF780A	284323	broad.mit.edu	37	19	40580998	40580998	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr19:40580998C>T	uc002omy.2	-	6	1576	c.1351G>A	c.(1351-1353)GAG>AAG	p.E451K	ZNF780A_uc002omw.3_Intron|ZNF780A_uc002omz.2_Missense_Mutation_p.E451K|ZNF780A_uc010xvh.1_Missense_Mutation_p.E452K	NM_001010880	NP_001010880	O75290	Z780A_HUMAN	zinc finger protein 780A isoform b	451	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					AAGGCCATCTCACATTCCCTA	0.403		NaN											0	0	0	0.00361	0	44	167				
C19orf48	84798	broad.mit.edu	37	19	51301486	51301486	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr19:51301486C>T	uc002ptf.2	-	5	1142	c.220G>A	c.(220-222)GAC>AAC	p.D74N	C19orf48_uc002pte.2_RNA|C19orf48_uc002ptg.2_Missense_Mutation_p.D74N	NM_199249	NP_954857	Q6RUI8	CS048_HUMAN	multidrug resistance-related protein	74										ovary(1)	1		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00531)|GBM - Glioblastoma multiforme(134;0.0145)		TAGGCCTGGTCACAATAGGGA	0.632		NaN											0	0	0	0.002299	0	23	129				
ZNF528	84436	broad.mit.edu	37	19	52909178	52909178	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr19:52909178G>A	uc002pzh.2	+	5	460	c.34G>A	c.(34-36)GAT>AAT	p.D12N	ZNF528_uc002pzi.2_5'UTR	NM_032423	NP_115799	Q3MIS6	ZN528_HUMAN	zinc finger protein 528	12	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)		GAAATTCATGGATGTGGCCAT	0.458		NaN											0	0	0	0.009718	0	39	234				
ZNF534	147658	broad.mit.edu	37	19	52942185	52942185	+	Missense_Mutation	SNP	A	A	G			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr19:52942185A>G	uc002pzk.2	+	4	1572	c.1511A>G	c.(1510-1512)GAG>GGG	p.E504G	ZNF534_uc002pzj.1_Intron|ZNF534_uc010epo.1_Intron|ZNF534_uc002pzl.2_Missense_Mutation_p.E491G	NM_001143939	NP_001137411	Q76KX8	ZN534_HUMAN	zinc finger protein 534 isoform 2	504					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CATACTGGAGAGAAGCTTTAC	0.398		NaN											0	0	0	0.000602	0	5	28				
NLRP9	338321	broad.mit.edu	37	19	56243996	56243996	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr19:56243996C>G	uc002qly.2	-	2	1229	c.1201G>C	c.(1201-1203)GAG>CAG	p.E401Q		NM_176820	NP_789790	Q7RTR0	NALP9_HUMAN	NLR family, pyrin domain containing 9	401	NACHT.					cytoplasm	ATP binding			skin(4)|ovary(2)|breast(1)	7		Colorectal(82;0.000133)|Ovarian(87;0.133)		GBM - Glioblastoma multiforme(193;0.123)		CAAATTCCCTCTGCAGCCAAA	0.458		NaN											0	0	0	0.003954	0	20	143				
ZNF71	58491	broad.mit.edu	37	19	57133733	57133733	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr19:57133733G>A	uc002qnm.3	+	3	1316	c.1078G>A	c.(1078-1080)GGC>AGC	p.G360S		NM_021216	NP_067039	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	360	C2H2-type 9.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		CAGCGAGTGCGGCAAGGCCTT	0.627		NaN											0	0	0	0.012319	0	21	98				
BIRC6	57448	broad.mit.edu	37	2	32640936	32640936	+	Silent	SNP	C	C	G			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr2:32640936C>G	uc010ezu.2	+	10	2711	c.2577C>G	c.(2575-2577)CTC>CTG	p.L859L		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	859					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					TTACCTCGCTCATTTTGCTTC	0.388		NaN											0	0	0	0.00333	0	22	26				
ANAPC1	64682	broad.mit.edu	37	2	112541911	112541911	+	Missense_Mutation	SNP	G	G	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr2:112541911G>T	uc002thi.2	-	41	5231	c.4984C>A	c.(4984-4986)CTT>ATT	p.L1662I		NM_022662	NP_073153	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	1662					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				skin(2)	2						TGCTTTAAAAGATGGAGTTCT	0.438		NaN											1	0	3.80469e-20	0.009535	4.43881e-20	21	148				
MARCO	8685	broad.mit.edu	37	2	119752005	119752005	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr2:119752005C>T	uc002tln.1	+	17	1604	c.1472C>T	c.(1471-1473)ACG>ATG	p.T491M	MARCO_uc010yyf.1_Missense_Mutation_p.T413M	NM_006770	NP_006761	Q9UEW3	MARCO_HUMAN	macrophage receptor with collagenous structure	491	SRCR.|Extracellular (Potential).				cell surface receptor linked signaling pathway|innate immune response	collagen|integral to plasma membrane	pattern recognition receptor activity|scavenger receptor activity			ovary(3)|skin(2)|central_nervous_system(1)	6						TGTCGGGGCACGGAGAGTACC	0.552		NaN											0	0	0	0.007413	0	17	60				
TTN	7273	broad.mit.edu	37	2	179404371	179404371	+	Silent	SNP	G	G	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr2:179404371G>A	uc010zfg.1	-	301	90941	c.90717C>T	c.(90715-90717)GAC>GAT	p.D30239D	uc002umo.2_RNA|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.D23934D|TTN_uc010zfi.1_Silent_p.D23867D|TTN_uc010zfj.1_Silent_p.D23742D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	31166							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GGACTTGGATGTCATCATATT	0.507		NaN											0	0	0	0.00623	0	38	56				
TTN	7273	broad.mit.edu	37	2	179528611	179528611	+	Missense_Mutation	SNP	T	T	G			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr2:179528611T>G	uc010zfk.1	-	15	1369	c.821A>C	c.(820-822)GAG>GCG	p.E274A	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron|TTN_uc010fre.1_Intron			Q8WZ42	TITIN_HUMAN	SubName: Full=Titin; Flags: Fragment;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCGGATAACCTCTTTGGAAGC	0.418		NaN											0	0	0	0.003271	0	30	115				
ZDBF2	57683	broad.mit.edu	37	2	207169716	207169716	+	Missense_Mutation	SNP	T	T	C			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr2:207169716T>C	uc002vbp.2	+	5	714	c.464T>C	c.(463-465)ATT>ACT	p.I155T		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	155							nucleic acid binding|zinc ion binding			ovary(3)	3						GTTCATAAAATTGGGGCCAGT	0.448		NaN											0	0	0	0.001855	0	14	10				
PCSK2	5126	broad.mit.edu	37	20	17339006	17339006	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr20:17339006G>A	uc002wpm.2	+	3	637	c.317G>A	c.(316-318)CGA>CAA	p.R106Q	PCSK2_uc002wpl.2_Missense_Mutation_p.R87Q|PCSK2_uc010zrm.1_Missense_Mutation_p.R71Q	NM_002594	NP_002585	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	106					enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			ovary(3)|central_nervous_system(2)|large_intestine(1)|pancreas(1)	7					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GGATTTGACCGAAAAAAGCGA	0.388		NaN											0	0	0	0.005443	0	22	52				
ADAMTS5	11096	broad.mit.edu	37	21	28302365	28302365	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr21:28302365C>T	uc002ymg.2	-	7	2794	c.2065G>A	c.(2065-2067)GAA>AAA	p.E689K		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	689	Cys-rich.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						AGCCTACATTCAGTGCCATCG	0.478		NaN											0	0	0	0.00874	0	38	102				
COMT	1312	broad.mit.edu	37	22	19951164	19951164	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr22:19951164C>T	uc002zqu.2	+	4	614	c.365C>T	c.(364-366)TCA>TTA	p.S122L	COMT_uc002zqt.2_Missense_Mutation_p.S122L|COMT_uc002zqv.2_Missense_Mutation_p.S122L|COMT_uc002zqw.2_Missense_Mutation_p.S122L|COMT_uc011ahd.1_Missense_Mutation_p.S122L|COMT_uc002zqx.2_Missense_Mutation_p.S122L	NM_000754	NP_000745	P21964	COMT_HUMAN	catechol-O-methyltransferase isoform MB-COMT	122		S-adenosyl-L-methionine.			neurotransmitter biosynthetic process|neurotransmitter catabolic process|xenobiotic metabolic process	cytosol|integral to membrane|intracellular membrane-bounded organelle|microsome|plasma membrane|soluble fraction	catechol O-methyltransferase activity|magnesium ion binding|protein binding			ovary(1)	1	Colorectal(54;0.0993)				Carbidopa(DB00190)|Conjugated Estrogens(DB00286)|Diethylstilbestrol(DB00255)|Dobutamine(DB00841)|Dopamine(DB00988)|Entacapone(DB00494)|Folic Acid(DB00158)|L-Valine(DB00161)|Levodopa(DB01235)|Methyldopa(DB00968)|Modafinil(DB00745)|Morphine(DB00295)|S-Adenosylmethionine(DB00118)|Tolcapone(DB00323)	TGTGGCTACTCAGCTGTGCGC	0.647		NaN											0	0	0	0.003755	0	33	38				
MTMR3	8897	broad.mit.edu	37	22	30415660	30415660	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr22:30415660G>A	uc003agv.3	+	17	2340	c.2012G>A	c.(2011-2013)AGA>AAA	p.R671K	MTMR3_uc003agu.3_Missense_Mutation_p.R671K|MTMR3_uc003agw.3_Missense_Mutation_p.R671K	NM_021090	NP_066576	Q13615	MTMR3_HUMAN	myotubularin-related protein 3 isoform c	671					phosphatidylinositol dephosphorylation	cytoplasm|membrane|membrane fraction|nucleus	metal ion binding|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity			breast(3)|ovary(1)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(5;0.00204)|Epithelial(10;0.06)|all cancers(5;0.107)			AAGCCCACCAGAGTGCCGGGG	0.622		NaN											0	0	0	0.00361	0	53	38				
ELFN2	114794	broad.mit.edu	37	22	37769638	37769638	+	Missense_Mutation	SNP	T	T	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr22:37769638T>A	uc003asq.3	-	3	2723	c.1937A>T	c.(1936-1938)GAC>GTC	p.D646V		NM_052906	NP_443138	Q5R3F8	LRFN6_HUMAN	leucine rich repeat containing 62	646	Cytoplasmic (Potential).					cell surface|integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	Melanoma(58;0.0574)					GTCGGGCACGTCCAGGCTAAA	0.672		NaN											0	0	0	0.001168	0	5	10				
CYB5R3	1727	broad.mit.edu	37	22	43032743	43032743	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr22:43032743G>A	uc003bcz.2	-	2	215	c.131C>T	c.(130-132)CCG>CTG	p.P44L	CYB5R3_uc010gzc.1_5'UTR|CYB5R3_uc003bcw.2_Missense_Mutation_p.P34L|CYB5R3_uc011aps.1_Missense_Mutation_p.P77L|CYB5R3_uc003bcy.2_Missense_Mutation_p.P21L|CYB5R3_uc003bcx.2_Missense_Mutation_p.P21L	NM_000398	NP_000389	P00387	NB5R3_HUMAN	cytochrome b5 reductase 3 isoform m	44	FAD-binding FR-type.				blood circulation|cholesterol biosynthetic process|water-soluble vitamin metabolic process	endoplasmic reticulum membrane|hemoglobin complex|mitochondrial outer membrane	cytochrome-b5 reductase activity			skin(1)	1					NADH(DB00157)	GAGCCGCAGCGGGTACTTGAT	0.632		NaN											0	0	0	0.004482	0	7	7				
OGG1	4968	broad.mit.edu	37	3	9798767	9798767	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr3:9798767G>A	uc003bsi.2	+	7	1314	c.971G>A	c.(970-972)CGC>CAC	p.R324H	OGG1_uc003bsh.2_3'UTR|OGG1_uc003bsj.2_Missense_Mutation_p.A330T|OGG1_uc003bsk.2_Intron|OGG1_uc003bsl.2_Intron|OGG1_uc003bsm.2_Intron|OGG1_uc003bsn.2_Intron|OGG1_uc003bso.2_Intron|OGG1_uc003bsp.1_Missense_Mutation_p.A95T|OGG1_uc010hcm.1_Missense_Mutation_p.A117T|OGG1_uc003bsq.1_Missense_Mutation_p.A39T|OGG1_uc003bsr.1_Missense_Mutation_p.R89H	NM_002542	NP_002533	O15527	OGG1_HUMAN	8-oxoguanine DNA-glycosylase 1 isoform 1a	324					depurination|nucleotide-excision repair|regulation of protein import into nucleus, translocation|regulation of transcription, DNA-dependent|response to oxidative stress|response to radiation	mitochondrion|nuclear matrix|nuclear speck	damaged DNA binding|endonuclease activity|oxidized purine base lesion DNA N-glycosylase activity|protein binding				0	Medulloblastoma(99;0.227)					GCCGACCTGCGCCAATCCCGC	0.602		NaN						BER_DNA_glycosylases					0	0	0	0.012213	0	32	110				
PPARG	5468	broad.mit.edu	37	3	12475606	12475606	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr3:12475606C>T	uc003bwx.2	+	7	1571	c.1480C>T	c.(1480-1482)CAC>TAC	p.H494Y	PPARG_uc003bwr.2_Missense_Mutation_p.H466Y|PPARG_uc003bws.2_Missense_Mutation_p.H466Y|PPARG_uc003bwu.2_Missense_Mutation_p.H466Y|PPARG_uc003bwv.2_3'UTR	NM_015869	NP_056953	P37231	PPARG_HUMAN	peroxisome proliferative activated receptor	494	Ligand-binding.				activation of caspase activity|cell fate commitment|cell maturation|cellular response to insulin stimulus|epithelial cell differentiation|glucose homeostasis|induction of apoptosis|innate immune response|lipid homeostasis|lipoprotein transport|long-chain fatty acid transport|low-density lipoprotein particle receptor biosynthetic process|monocyte differentiation|negative regulation of cholesterol storage|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of macrophage derived foam cell differentiation|negative regulation of receptor biosynthetic process|negative regulation of sequestering of triglyceride|negative regulation of transcription from RNA polymerase II promoter|placenta development|positive regulation of fat cell differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to lipid|response to low-density lipoprotein particle stimulus|white fat cell differentiation	cytosol|nucleoplasm	activating transcription factor binding|arachidonic acid binding|drug binding|enzyme binding|prostaglandin receptor activity|retinoid X receptor binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)|kidney(1)	2					Atorvastatin(DB01076)|Icosapent(DB00159)|Pioglitazone(DB01132)|Rosiglitazone(DB00412)|Troglitazone(DB00197)	CATGAGTCTTCACCCGCTCCT	0.502		NaN	T	PAX8	follicular thyroid		Insulin resistance ; lipodystrophy|familial partial L;diabetes mellitus|insulin-resistantI|with acanthosis nigricans and hypertension						0	0	0	0.012213	0	29	16				
GLYCTK	132158	broad.mit.edu	37	3	52326880	52326880	+	Missense_Mutation	SNP	G	G	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr3:52326880G>T	uc003ddo.2	+	5	1406	c.1310G>T	c.(1309-1311)TGG>TTG	p.W437L	GLYCTK_uc003ddq.2_3'UTR|GLYCTK_uc003ddm.2_Intron|GLYCTK_uc003ddn.2_Intron|GLYCTK_uc003ddp.1_Intron|GLYCTK_uc003ddr.2_Missense_Mutation_p.W101L	NM_145262	NP_660305	Q8IVS8	GLCTK_HUMAN	glycerate kinase isoform 1	437					protein phosphorylation	Golgi apparatus|mitochondrion	ATP binding|glycerate kinase activity|protein binding				0				BRCA - Breast invasive adenocarcinoma(193;3.56e-05)|Kidney(197;0.00171)|KIRC - Kidney renal clear cell carcinoma(197;0.00194)|OV - Ovarian serous cystadenocarcinoma(275;0.235)		TTGAGAAGGTGGCCGCTGGGG	0.662		NaN											1	0	1.81118e-26	0.00361	2.13279e-26	44	34				
OR5K1	26339	broad.mit.edu	37	3	98188871	98188871	+	Missense_Mutation	SNP	G	G	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr3:98188871G>T	uc003dsm.2	+	1	451	c.451G>T	c.(451-453)GCT>TCT	p.A151S		NM_001004736	NP_001004736	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K,	151	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)	1						GGCCTTCATAGCTGGAAACCT	0.443		NaN											1	0	4.14481e-20	0.00623	4.79125e-20	39	76				
TAGLN3	29114	broad.mit.edu	37	3	111719695	111719695	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr3:111719695C>T	uc003dym.2	+	3	635	c.257C>T	c.(256-258)GCT>GTT	p.A86V	TAGLN3_uc003dyl.2_Missense_Mutation_p.A86V|TAGLN3_uc003dyn.2_Missense_Mutation_p.A86V|TAGLN3_uc003dyo.2_Missense_Mutation_p.A86V	NM_001008272	NP_001008273	Q9UI15	TAGL3_HUMAN	transgelin 3	86	CH.				central nervous system development|muscle organ development						0						TCAAAGATGGCTTTTAAGCAG	0.488		NaN											0	0	0	0.00361	0	60	225				
GRAMD1C	54762	broad.mit.edu	37	3	113627845	113627845	+	Missense_Mutation	SNP	A	A	C			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr3:113627845A>C	uc003eaq.3	+	9	906	c.830A>C	c.(829-831)AAA>ACA	p.K277T	GRAMD1C_uc011bil.1_RNA|GRAMD1C_uc011bim.1_RNA|GRAMD1C_uc003ear.2_Missense_Mutation_p.K110T|GRAMD1C_uc003eas.2_Missense_Mutation_p.K72T	NM_017577	NP_060047	Q8IYS0	GRM1C_HUMAN	GRAM domain containing 1C	277						integral to membrane				ovary(2)|skin(1)	3						AAACAGACCAAAAAGAGTCTC	0.363		NaN											0	0	0	0.00361	0	77	20				
PARP15	165631	broad.mit.edu	37	3	122354758	122354758	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr3:122354758C>A	uc003efm.2	+	12	1914	c.1848C>A	c.(1846-1848)TAC>TAA	p.Y616*	PARP15_uc003efn.2_Nonsense_Mutation_p.Y421*|PARP15_uc003efo.1_Nonsense_Mutation_p.Y363*|PARP15_uc003efp.1_Nonsense_Mutation_p.Y382*|PARP15_uc011bjt.1_Nonsense_Mutation_p.Y313*	NM_001113523	NP_001106995	Q460N3	PAR15_HUMAN	poly (ADP-ribose) polymerase family, member 15	594	PARP catalytic.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	NAD+ ADP-ribosyltransferase activity			lung(3)|upper_aerodigestive_tract(1)|ovary(1)	5				GBM - Glioblastoma multiforme(114;0.0531)		AGCACATGTACGTTGTGCGAG	0.483		NaN											1	0	1.33834e-09	0.007413	1.44129e-09	19	65				
CEP63	80254	broad.mit.edu	37	3	134278206	134278206	+	Missense_Mutation	SNP	A	A	G			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr3:134278206A>G	uc003eqo.1	+	15	2337	c.1888A>G	c.(1888-1890)AAT>GAT	p.N630D	CEP63_uc003eql.1_Intron|CEP63_uc003eqm.2_Intron|CEP63_uc003eqn.1_Intron	NM_025180	NP_079456	Q96MT8	CEP63_HUMAN	centrosomal protein 63 isoform a	630					cell division|DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitosis|signal transduction in response to DNA damage|spindle assembly	centrosome|cytosol|spindle pole	protein binding			ovary(1)	1						GCTAGATACAAATGAAGCCAA	0.403		NaN											0	0	0	0.008871	0	21	60				
SI	6476	broad.mit.edu	37	3	164697153	164697153	+	Silent	SNP	T	T	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr3:164697153T>A	uc003fei.2	-	48	5543	c.5481A>T	c.(5479-5481)TCA>TCT	p.S1827S		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1827	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GTGATCTTCATGACCAGTTGA	0.318		NaN								HNSCC(35;0.089)			0	0	0	0.008361	0	28	117				
WDR1	9948	broad.mit.edu	37	4	10079467	10079467	+	Silent	SNP	G	G	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr4:10079467G>A	uc003gmf.2	-	13	1762	c.1479C>T	c.(1477-1479)ACC>ACT	p.T493T	WDR1_uc003gmg.2_Silent_p.T353T|WDR1_uc010idm.2_RNA	NM_017491	NP_059830	O75083	WDR1_HUMAN	WD repeat-containing protein 1 isoform 1	493	WD 9.				platelet activation|platelet degranulation|sensory perception of sound	cytoskeleton|cytosol|extracellular region	actin binding			ovary(2)|pancreas(1)	3				STAD - Stomach adenocarcinoma(129;0.000703)|Colorectal(103;0.0057)|LUSC - Lung squamous cell carcinoma(721;0.0232)		AGGCCACGTCGGTCACGGGGC	0.652		NaN											0	0	0	0.000602	0	5	8				
PCDH7	5099	broad.mit.edu	37	4	30726012	30726012	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr4:30726012C>T	uc003gsk.1	+	1	3976	c.2968C>T	c.(2968-2970)CCT>TCT	p.P990S	PCDH7_uc011bxw.1_Missense_Mutation_p.P943S|PCDH7_uc011bxx.1_Missense_Mutation_p.P990S	NM_002589	NP_002580	O60245	PCDH7_HUMAN	protocadherin 7 isoform a precursor	990	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			upper_aerodigestive_tract(1)|ovary(1)|liver(1)|skin(1)	4						GCCCGGCAGTCCTGACCTGGC	0.507		NaN											0	0	0	0.006122	0	18	41				
PRKG2	5593	broad.mit.edu	37	4	82058586	82058586	+	Missense_Mutation	SNP	G	G	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr4:82058586G>T	uc003hmh.2	-	12	1609	c.1595C>A	c.(1594-1596)GCC>GAC	p.A532D	PRKG2_uc011ccf.1_Missense_Mutation_p.A112D|PRKG2_uc011ccg.1_Missense_Mutation_p.A112D|PRKG2_uc011cch.1_Missense_Mutation_p.A503D	NM_006259	NP_006250	Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	532	Protein kinase.				platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			breast(3)|central_nervous_system(2)|ovary(1)|large_intestine(1)	7						ACCTAAGCAGGCCTCCAGAAG	0.338		NaN											1	0	4.59853e-10	0.005443	5.03839e-10	23	64				
GRID2	2895	broad.mit.edu	37	4	94344056	94344056	+	Silent	SNP	C	C	T	rs78407646	byFrequency	TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr4:94344056C>T	uc011cdt.1	+	10	1740	c.1482C>T	c.(1480-1482)CAC>CAT	p.H494H	GRID2_uc011cdu.1_Silent_p.H399H	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	494	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	CACCGGATCACAAATACGGAA	0.398		NaN											0	0	0	0.012319	0	19	39				
MAP1B	4131	broad.mit.edu	37	5	71492471	71492471	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr5:71492471G>A	uc003kbw.3	+	5	3530	c.3289G>A	c.(3289-3291)GAG>AAG	p.E1097K	MAP1B_uc010iyw.1_Missense_Mutation_p.E1114K|MAP1B_uc010iyx.1_Missense_Mutation_p.E971K|MAP1B_uc010iyy.1_Missense_Mutation_p.E971K	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	1097						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		CTCAGAGAGCGAGGCCACCGC	0.522		NaN											0	0	0	0.004482	0	8	14				
CAMK4	814	broad.mit.edu	37	5	110784840	110784840	+	Silent	SNP	C	C	G			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr5:110784840C>G	uc011cvj.1	+	8	663	c.564C>G	c.(562-564)CTC>CTG	p.L188L	CAMK4_uc003kpf.2_Silent_p.L188L|CAMK4_uc010jbv.2_5'UTR	NM_001744	NP_001735	Q16566	KCC4_HUMAN	calcium/calmodulin-dependent protein kinase IV	188	Protein kinase.				activation of phospholipase C activity|nerve growth factor receptor signaling pathway|synaptic transmission	cytosol|nucleoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(3)|lung(2)	5		all_cancers(142;1.49e-05)|all_epithelial(76;1.82e-07)|Prostate(80;0.00964)|all_lung(232;0.0181)|Lung NSC(167;0.0298)|Ovarian(225;0.0446)|Colorectal(57;0.0478)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;3.79e-08)|Epithelial(69;5.29e-08)|all cancers(49;1.1e-05)|COAD - Colon adenocarcinoma(37;0.109)		ATTTTGGACTCTCTAAAATTG	0.299		NaN											0	0	0	0.004482	0	9	29				
FAM170A	340069	broad.mit.edu	37	5	118969677	118969677	+	Missense_Mutation	SNP	C	C	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr5:118969677C>A	uc003ksm.2	+	3	444	c.234C>A	c.(232-234)GAC>GAA	p.D78E	FAM170A_uc003ksl.2_Missense_Mutation_p.D78E|FAM170A_uc003ksn.2_Missense_Mutation_p.D78E|FAM170A_uc003kso.2_Missense_Mutation_p.D31E	NM_182761	NP_877438	A1A519	F170A_HUMAN	family with sequence similarity 170, member A	78						intracellular	zinc ion binding			skin(1)	1						TACATCGAGACAGCCCCCAGC	0.502		NaN											1	0	0.00198382	0.001984	0.00201582	7	35				
RAPGEF6	51735	broad.mit.edu	37	5	130834176	130834176	+	Missense_Mutation	SNP	T	T	C			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr5:130834176T>C	uc003kvn.1	-	12	1585	c.1379A>G	c.(1378-1380)AAA>AGA	p.K460R	RAPGEF6_uc003kvp.1_Missense_Mutation_p.K510R|RAPGEF6_uc003kvo.1_Missense_Mutation_p.K460R|RAPGEF6_uc010jdi.1_Missense_Mutation_p.K460R|RAPGEF6_uc010jdj.1_Missense_Mutation_p.K460R|RAPGEF6_uc003kvq.2_Missense_Mutation_p.K177R|RAPGEF6_uc003kvr.2_Missense_Mutation_p.K460R|RAPGEF6_uc011cxe.1_RNA|RAPGEF6_uc010jdk.2_Missense_Mutation_p.K460R	NM_016340	NP_057424	Q8TEU7	RPGF6_HUMAN	PDZ domain-containing guanine nucleotide	460	N-terminal Ras-GEF.				Ras protein signal transduction|regulation of GTPase activity|regulation of small GTPase mediated signal transduction	cytoplasm|plasma membrane	GTP-dependent protein binding|guanyl-nucleotide exchange factor activity|Ras GTPase binding			ovary(1)|lung(1)|central_nervous_system(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0721)		TTCCAATAGTTTGATCCCAAC	0.318		NaN											0	0	0	0.00361	0	64	23				
CSF1R	1436	broad.mit.edu	37	5	149449851	149449851	+	Missense_Mutation	SNP	T	T	G			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr5:149449851T>G	uc003lrl.2	-	8	1408	c.1213A>C	c.(1213-1215)AGC>CGC	p.S405R	CSF1R_uc011dcd.1_Missense_Mutation_p.S257R|CSF1R_uc010jhc.2_RNA|CSF1R_uc003lrm.2_Missense_Mutation_p.S405R	NM_005211	NP_005202	P07333	CSF1R_HUMAN	colony stimulating factor 1 receptor precursor	405	Ig-like C2-type 5.|Extracellular (Potential).				cell proliferation|multicellular organismal development|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|receptor complex	ATP binding|cytokine binding|macrophage colony-stimulating factor receptor activity|protein homodimerization activity			haematopoietic_and_lymphoid_tissue(38)|lung(6)|central_nervous_system(3)|liver(3)|breast(2)|endometrium(1)|ovary(1)	54			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)		Imatinib(DB00619)|Sunitinib(DB01268)	CATATGACGCTTACCTCTGGG	0.597		NaN											0	0	0	0.007835	0	32	21				
PECI	10455	broad.mit.edu	37	6	4133898	4133898	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr6:4133898C>T	uc003mwf.2	-	2	135	c.98G>A	c.(97-99)AGA>AAA	p.R33K	PECI_uc003mwc.2_5'UTR|PECI_uc003mwd.2_Missense_Mutation_p.R3K|PECI_uc003mwe.2_5'UTR|PECI_uc010jnr.1_RNA|uc003mwg.1_5'Flank	NM_206836	NP_996667	O75521	ECI2_HUMAN	peroxisomal D3,D2-enoyl-CoA isomerase isoform 2	33					fatty acid metabolic process	mitochondrion|peroxisomal matrix	dodecenoyl-CoA delta-isomerase activity|fatty-acyl-CoA binding				0	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				CATTGCTGTTCTATTCATGTG	0.413		NaN											0	0	0	0.00361	0	48	32				
HIVEP1	3096	broad.mit.edu	37	6	12120592	12120592	+	Silent	SNP	C	C	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr6:12120592C>T	uc003nac.2	+	4	743	c.564C>T	c.(562-564)TCC>TCT	p.S188S	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	188					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				GCACTACGTCCCCCTCCTATA	0.448		NaN											0	0	0	0.003755	0	31	45				
CLIC5	53405	broad.mit.edu	37	6	45917028	45917028	+	Silent	SNP	G	G	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr6:45917028G>T	uc003oxv.3	-	3	847	c.741C>A	c.(739-741)ATC>ATA	p.I247I	CLIC5_uc003oxu.3_Silent_p.I88I|CLIC5_uc003oxx.2_Silent_p.I88I	NM_001114086	NP_001107558	Q9NZA1	CLIC5_HUMAN	chloride intracellular channel 5 isoform a	247					female pregnancy	actin cytoskeleton|cell cortex|chloride channel complex|Golgi apparatus|Golgi apparatus|insoluble fraction|microtubule organizing center	protein binding|voltage-gated chloride channel activity			ovary(1)|skin(1)	2						GGAACTCCTCGATCTTATTGA	0.532		NaN											1	0	8.4185e-14	0.012213	9.47082e-14	29	73				
NMBR	4829	broad.mit.edu	37	6	142397093	142397093	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr6:142397093G>A	uc003qiu.2	-	3	1006	c.865C>T	c.(865-867)CGG>TGG	p.R289W		NM_002511	NP_002502	P28336	NMBR_HUMAN	neuromedin B receptor	289	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	cytoplasm|integral to plasma membrane	bombesin receptor activity			central_nervous_system(3)|breast(1)	4	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;9.93e-06)|GBM - Glioblastoma multiforme(68;0.0013)		TTGAAAGACCGATACATGTAA	0.428		NaN											0	0	0	0.002299	0	23	27				
STXBP5	134957	broad.mit.edu	37	6	147648378	147648378	+	Silent	SNP	C	C	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr6:147648378C>T	uc003qlz.2	+	18	2207	c.2046C>T	c.(2044-2046)CCC>CCT	p.P682P	STXBP5_uc010khz.1_Silent_p.P682P|STXBP5_uc003qlx.2_RNA|STXBP5_uc003qly.2_Silent_p.P353P|STXBP5_uc003qma.2_Silent_p.P29P	NM_001127715	NP_001121187	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn) isoform b	682	WD 10.				exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		GGAGAGAACCCCGATCTCCTC	0.418		NaN											0	0	0	0.003271	0	27	23				
GLCCI1	113263	broad.mit.edu	37	7	8110599	8110599	+	Silent	SNP	C	C	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr7:8110599C>A	uc003srk.2	+	6	1574	c.1015C>A	c.(1015-1017)CGG>AGG	p.R339R		NM_138426	NP_612435	Q86VQ1	GLCI1_HUMAN	glucocorticoid induced transcript 1	339											0		Ovarian(82;0.0608)		UCEC - Uterine corpus endometrioid carcinoma (126;0.206)		TGCTCATTACCGGAGCAGTAG	0.493		NaN											1	0	2.70639e-06	0.002299	2.81823e-06	21	60				
UPK3B	80761	broad.mit.edu	37	7	76140331	76140331	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr7:76140331C>T	uc003ufq.2	+	1	587	c.362C>T	c.(361-363)GCC>GTC	p.A121V	UPK3B_uc003ufo.2_Missense_Mutation_p.A66V|UPK3B_uc010ldk.1_Missense_Mutation_p.A66V	NM_030570	NP_085047	Q9BT76	UPK3B_HUMAN	uroplakin 3B isoform a	121	Lumenal (Potential).				negative regulation of gene expression	integral to membrane|plasma membrane				central_nervous_system(1)	1		Myeloproliferative disorder(862;0.204)				CTTGCCAGCGCCAGCGATACC	0.632		NaN											0	0	0	0.000602	0	5	19				
SLC25A40	55972	broad.mit.edu	37	7	87476434	87476434	+	Missense_Mutation	SNP	C	C	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr7:87476434C>A	uc003uje.2	-	8	812	c.461G>T	c.(460-462)GGT>GTT	p.G154V		NM_018843	NP_061331	Q8TBP6	S2540_HUMAN	mitochondrial carrier family protein	154	Helical; Name=3; (Potential).|Solcar 2.				transmembrane transport	integral to membrane|mitochondrial inner membrane	binding			haematopoietic_and_lymphoid_tissue(1)	1	Esophageal squamous(14;0.00202)					AGTTACTGCACCAACTAATAC	0.303		NaN											1	0	5.1993e-48	0.00361	6.18029e-48	116	108				
TECPR1	25851	broad.mit.edu	37	7	97862830	97862830	+	Silent	SNP	C	C	G			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr7:97862830C>G	uc003upg.2	-	11	1780	c.1575G>C	c.(1573-1575)CCG>CCC	p.P525P	TECPR1_uc003uph.1_Silent_p.P455P	NM_015395	NP_056210	Q7Z6L1	TCPR1_HUMAN	tectonin beta-propeller repeat containing 1	525						integral to membrane	protein binding			pancreas(1)	1						CCACCCCATACGGCTCCTCCA	0.667		NaN											0	0	0	0.000602	0	5	12				
BAIAP2L1	55971	broad.mit.edu	37	7	97922840	97922840	+	Missense_Mutation	SNP	A	A	G			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr7:97922840A>G	uc003upj.2	-	14	1792	c.1529T>C	c.(1528-1530)ATT>ACT	p.I510T		NM_018842	NP_061330	Q9UHR4	BI2L1_HUMAN	BAI1-associated protein 2-like 1	510	Binds F-actin.			Missing: Loss ability to induce the formation of actin clusters; induce the formation of long filopodia.	filopodium assembly|positive regulation of actin cytoskeleton reorganization|positive regulation of actin filament polymerization|response to bacterium|signal transduction	cell junction|cytoskeleton|cytosol|nucleus	actin binding|cytoskeletal adaptor activity|proline-rich region binding|SH3 domain binding			ovary(1)	1	all_cancers(62;4.34e-10)|all_epithelial(64;5e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0113)|all_lung(186;0.0126)		STAD - Stomach adenocarcinoma(171;0.215)			CTCTCATCGAATGATGGGTGC	0.567		NaN											0	0	0	0.00361	0	153	90				
EXOC4	60412	broad.mit.edu	37	7	133314839	133314839	+	Missense_Mutation	SNP	T	T	C			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr7:133314839T>C	uc003vrk.2	+	10	1494	c.1459T>C	c.(1459-1461)TTT>CTT	p.F487L	EXOC4_uc011kpo.1_Missense_Mutation_p.F386L|EXOC4_uc003vrl.2_Missense_Mutation_p.F97L|EXOC4_uc011kpp.1_Missense_Mutation_p.F19L	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	487					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				AGGAACAAAATTTGTCTGCAA	0.343		NaN											0	0	0	0.00361	0	104	61				
CNTNAP2	26047	broad.mit.edu	37	7	147869367	147869367	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr7:147869367G>A	uc003weu.1	+	18	3323	c.2807G>A	c.(2806-2808)TGC>TAC	p.C936Y		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	936	Laminin G-like 3.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TTCCTGGGCTGCATCCGCTCC	0.532		NaN								HNSCC(39;0.1)			0	0	0	0.004482	0	9	65				
SORBS3	10174	broad.mit.edu	37	8	22412401	22412401	+	Missense_Mutation	SNP	C	C	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr8:22412401C>T	uc003xbv.2	+	3	468	c.128C>T	c.(127-129)TCC>TTC	p.S43F	SORBS3_uc011kzk.1_RNA	NM_005775	NP_005766	O60504	VINEX_HUMAN	sorbin and SH3 domain containing 3 isoform 1	43					muscle contraction|positive regulation of stress fiber assembly	cytoskeleton|cytosol|nucleus	protein binding|structural constituent of cytoskeleton|vinculin binding				0		Prostate(55;0.0421)|Breast(100;0.102)		BRCA - Breast invasive adenocarcinoma(99;0.00566)|Colorectal(74;0.0146)|COAD - Colon adenocarcinoma(73;0.061)		AATGGTGGCTCCAACACCCTT	0.657		NaN											0	0	0	0.010771	0	39	57				
ZFHX4	79776	broad.mit.edu	37	8	77766952	77766952	+	Missense_Mutation	SNP	G	G	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr8:77766952G>A	uc003yav.2	+	10	8047	c.7660G>A	c.(7660-7662)GGT>AGT	p.G2554S	ZFHX4_uc003yau.1_Missense_Mutation_p.G2599S|ZFHX4_uc003yaw.1_Missense_Mutation_p.G2554S	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2554						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AGGGAATAGCGGTGAAGACCA	0.458		NaN								HNSCC(33;0.089)			0	0	0	0.001368	0	12	29				
SLC10A5	347051	broad.mit.edu	37	8	82606405	82606405	+	Missense_Mutation	SNP	T	T	G			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr8:82606405T>G	uc011lfs.1	-	1	803	c.803A>C	c.(802-804)CAT>CCT	p.H268P		NM_001010893	NP_001010893	Q5PT55	NTCP5_HUMAN	solute carrier family 10 (sodium/bile acid	268	Extracellular (Potential).					integral to membrane	bile acid:sodium symporter activity				0						AACAGGAATATGGAATGTACC	0.363		NaN											0	0	0	0.000602	0	4	123				
STK3	6788	broad.mit.edu	37	8	99468111	99468111	+	Missense_Mutation	SNP	C	C	G			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr8:99468111C>G	uc003yip.2	-	11	1576	c.1435G>C	c.(1435-1437)GAT>CAT	p.D479H	STK3_uc003yio.2_Missense_Mutation_p.D507H	NM_006281	NP_006272	Q13188	STK3_HUMAN	serine/threonine kinase 3	479	SARAH.				apoptosis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of apoptosis	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein dimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity			lung(3)|ovary(1)	4	Breast(36;2.4e-06)	Breast(495;0.106)	OV - Ovarian serous cystadenocarcinoma(57;0.0382)	KIRC - Kidney renal clear cell carcinoma(542;9.44e-06)		TCCATCGCATCCAGAATGGGC	0.423		NaN											0	0	0	0.00278	0	20	25				
RSPO2	340419	broad.mit.edu	37	8	108972969	108972969	+	Silent	SNP	A	A	G	rs113070894		TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr8:108972969A>G	uc003yms.2	-	4	1018	c.360T>C	c.(358-360)CAT>CAC	p.H120H	RSPO2_uc003ymq.2_Silent_p.H53H|RSPO2_uc003ymr.2_Silent_p.H57H	NM_178565	NP_848660	Q6UXX9	RSPO2_HUMAN	R-spondin family, member 2 precursor	120	FU.				Wnt receptor signaling pathway	extracellular region	heparin binding			skin(3)|ovary(2)|pancreas(1)|lung(1)	7			OV - Ovarian serous cystadenocarcinoma(57;1.55e-09)			AACGGCCTCTATGCAAATAAA	0.358		NaN											0	0	0	0.004289	0	30	46				
SLC30A8	169026	broad.mit.edu	37	8	118159254	118159254	+	Missense_Mutation	SNP	C	C	A	rs148043363	byFrequency	TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr8:118159254C>A	uc003yoh.2	+	2	363	c.133C>A	c.(133-135)CTG>ATG	p.L45M	SLC30A8_uc010mcz.2_Translation_Start_Site|SLC30A8_uc011lia.1_Translation_Start_Site|SLC30A8_uc003yog.2_Translation_Start_Site	NM_173851	NP_776250	Q8IWU4	ZNT8_HUMAN	solute carrier family 30 member 8	45	Cytoplasmic (Potential).				insulin secretion|positive regulation of insulin secretion|regulation of sequestering of zinc ion|regulation of vesicle-mediated transport|response to glucose stimulus|sequestering of zinc ion	integral to membrane|plasma membrane|secretory granule membrane|transport vesicle membrane	protein homodimerization activity|zinc ion transmembrane transporter activity			ovary(2)|skin(2)	4	all_cancers(13;2.11e-22)|Lung NSC(37;6.08e-05)|Ovarian(258;0.0173)		STAD - Stomach adenocarcinoma(47;0.203)			ACCAGAGGAGCTGGAGTCAGG	0.502		NaN											1	0	4.16155e-14	0.00874	4.72392e-14	43	95				
PARP10	84875	broad.mit.edu	37	8	145057980	145057980	+	Splice_Site	SNP	C	C	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr8:145057980C>T	uc003zal.3	-	8	1886	c.1778_splice	c.e8-1	p.E593_splice	PARP10_uc003zak.3_Splice_Site_p.E290_splice|PARP10_uc011lku.1_Splice_Site_p.E605_splice|PARP10_uc011lkv.1_Splice_Site|PARP10_uc003zam.2_Splice_Site_p.E584_splice	NM_032789	NP_116178	Q53GL7	PAR10_HUMAN	poly (ADP-ribose) polymerase family, member 10							Golgi apparatus|nucleolus	NAD+ ADP-ribosyltransferase activity|nucleotide binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|breast(1)|pancreas(1)	6	all_cancers(97;8.2e-11)|all_epithelial(106;1.1e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.31e-40)|Epithelial(56;1.16e-39)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CGGACCTCCTCTGGGGGCAGG	0.632		NaN											0	0	0	0.008291	0	9	35				
CDKN2A	1029	broad.mit.edu	37	9	21971120	21971120	+	Nonsense_Mutation	SNP	G	G	A	rs121913388		TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr9:21971120G>A	uc003zpk.2	-	2	450	c.238C>T	c.(238-240)CGA>TGA	p.R80*	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Missense_Mutation_p.P135L	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	80	ANK 3.		R -> P (in CMM2; loss of CDK4 binding).|R -> L (in a head and neck tumor).		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.R80*(88)|p.?(13)|p.R80Q(2)|p.P135L(2)|p.T79fs*37(1)|p.L65fs*38(1)|p.R80fs*66(1)|p.A76fs*64(1)|p.T79fs*65(1)|p.E61_L94del(1)|p.A68fs*3(1)|p.R80fs*34(1)|p.R80?(1)|p.R80L(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		TGCACGGGTCGGGTGAGAGTG	0.726	R80*(MEWO_SKIN)|R80*(HSC4_UPPER_AERODIGESTIVE_TRACT)	17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			0	0	0	0.00245	0	10	2		Valid		
ZCCHC6	79670	broad.mit.edu	37	9	88937354	88937354	+	Missense_Mutation	SNP	C	C	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr9:88937354C>A	uc004aoq.2	-	14	3129	c.2914G>T	c.(2914-2916)GGT>TGT	p.G972C	ZCCHC6_uc010mqe.2_5'Flank|ZCCHC6_uc011ltf.1_RNA|ZCCHC6_uc004aor.2_RNA|ZCCHC6_uc004aos.2_RNA|ZCCHC6_uc004aot.2_Intron|ZCCHC6_uc004aou.2_Missense_Mutation_p.G972C	NM_024617	NP_078893	Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	972	CCHC-type 1.				RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)	2						TTTAGATGACCCTCTCGTTTG	0.408		NaN											1	0	3.41278e-10	0.00499	3.77202e-10	15	36				
DAPK1	1612	broad.mit.edu	37	9	90262309	90262309	+	Silent	SNP	G	G	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr9:90262309G>T	uc004apc.2	+	14	1458	c.1320G>T	c.(1318-1320)GTG>GTT	p.V440V	DAPK1_uc004ape.2_Silent_p.V440V|DAPK1_uc004apd.2_Silent_p.V440V|DAPK1_uc011ltg.1_Silent_p.V440V|DAPK1_uc011lth.1_Silent_p.V177V|DAPK1_uc004apf.1_5'UTR	NM_004938	NP_004929	P53355	DAPK1_HUMAN	death-associated protein kinase 1	440	ANK 2.				apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2						CTTTGGATGTGAAAGACAAGG	0.522		NaN							Chronic_Lymphocytic_Leukemia_Familial_Clustering_of				1	0	6.94344e-10	0.006122	7.54202e-10	15	47				
CKS2	1164	broad.mit.edu	37	9	91926143	91926143	+	Translation_Start_Site	SNP	C	C	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr9:91926143C>T	uc004aqh.2	+	1	31	c.-64C>T	c.(-66--62)GACGT>GATGT		hsa-mir-3153|MI0014180_5'Flank	NM_001827	NP_001818	P33552	CKS2_HUMAN	CDC28 protein kinase 2						cell division|cell proliferation|phosphatidylinositol-mediated signaling|regulation of cyclin-dependent protein kinase activity|spindle organization		cyclin-dependent protein kinase regulator activity				0						CTGGGCTGGACGTGGTTTTGT	0.607		NaN											0	0	0	0.001984	0	7	22				
ABL1	25	broad.mit.edu	37	9	133729585	133729585	+	Missense_Mutation	SNP	T	T	G			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr9:133729585T>G	uc004bzw.2	+	2	217	c.214T>G	c.(214-216)TTT>GTT	p.F72V	ABL1_uc004bzv.2_Missense_Mutation_p.F91V	NM_005157	NP_005148	P00519	ABL1_HUMAN	c-abl oncogene 1, receptor tyrosine kinase	72	SH3.				actin cytoskeleton organization|axon guidance|blood coagulation|cell adhesion|DNA damage induced protein phosphorylation|DNA damage response, signal transduction resulting in induction of apoptosis|mismatch repair|muscle cell differentiation|negative regulation of protein serine/threonine kinase activity|peptidyl-tyrosine phosphorylation|positive regulation of muscle cell differentiation|positive regulation of oxidoreductase activity|regulation of transcription involved in S phase of mitotic cell cycle	cytoskeleton|cytosol|nuclear membrane|nucleolus|perinuclear region of cytoplasm	ATP binding|DNA binding|magnesium ion binding|manganese ion binding|mitogen-activated protein kinase binding|non-membrane spanning protein tyrosine kinase activity|proline-rich region binding|protein C-terminus binding|SH3 domain binding			haematopoietic_and_lymphoid_tissue(807)|lung(5)|stomach(2)|central_nervous_system(1)|breast(1)|skin(1)	817		all_hematologic(13;0.0361)|Acute lymphoblastic leukemia(5;0.0543)|Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;5.4e-05)	Adenosine triphosphate(DB00171)|Dasatinib(DB01254)|Imatinib(DB00619)	ACTGTATGATTTTGTGGCCAG	0.488		NaN	T|Mis	BCR|ETV6|NUP214	CML|ALL|T-ALL								0	0	0	0.009096	0	4	89				
ZCCHC18	644353	broad.mit.edu	37	X	103359015	103359015	+	Silent	SNP	C	C	T			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chrX:103359015C>T	uc011msh.1	+	3	1529	c.213C>T	c.(211-213)GTC>GTT	p.V71V	MCART6_uc004elu.2_Intron|ZCCHC18_uc011msg.1_Intron	NM_001143978	NP_001137450	P0CG32	ZCC18_HUMAN	zinc finger, CCHC domain containing 18	71							nucleic acid binding|zinc ion binding				0						TCAATGAGGTCCTGCCAGATT	0.507		NaN											0	0	0	0.003954	0	24	7				
ANGPTL5	253935	broad.mit.edu	37	11	101762080	101762080	+	Frame_Shift_Del	DEL	T	T	-			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr11:101762080delT	uc001pgl.2	-	9	1693	c.1097delA	c.(1096-1098)AACfs	p.N366fs		NM_178127	NP_835228	Q86XS5	ANGL5_HUMAN	angiopoietin-like 5 precursor	366	Fibrinogen C-terminal.				signal transduction	extracellular space	receptor binding			ovary(1)	1		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.043)		BRCA - Breast invasive adenocarcinoma(274;0.0328)		AGGTGAGTTGTTTTTGGTCCA	0.348		NaN											NaN	NaN	NaN	NaN	NaN	7	1294	---		---	---
MMP20	9313	broad.mit.edu	37	11	102487558	102487558	+	Frame_Shift_Del	DEL	T	T	-			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr11:102487558delT	uc001phc.2	-	2	372	c.359delA	c.(358-360)AATfs	p.N120fs		NM_004771	NP_004762	O60882	MMP20_HUMAN	matrix metalloproteinase 20 preproprotein	120					proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			urinary_tract(1)|skin(1)	2	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		TGTCAAAGTATTTTTTTTCCA	0.398		NaN											NaN	NaN	NaN	NaN	NaN	8	296	---		---	---
MMP1	4312	broad.mit.edu	37	11	102668791	102668793	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr11:102668791_102668793delCAG	uc001phi.2	-	1	174_176	c.31_33delCTG	c.(31-33)CTGdel	p.L11del	uc001phh.1_RNA|MMP1_uc010ruv.1_Intron	NM_002421	NP_002412	P03956	MMP1_HUMAN	matrix metalloproteinase 1 isoform 1	11					blood coagulation|collagen catabolic process|interspecies interaction between organisms|leukocyte migration|proteolysis	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(2)|ovary(1)|lung(1)	4	all_epithelial(12;0.0127)	all_neural(303;0.000318)|all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.072)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.233)	OV - Ovarian serous cystadenocarcinoma(223;1.82e-07)|Epithelial(105;1.51e-06)|BRCA - Breast invasive adenocarcinoma(274;0.014)		CACCCCAGAACAGCAGCAGCAGC	0.498		NaN											NaN	NaN	NaN	NaN	NaN	8	339	---		---	---
SSH1	54434	broad.mit.edu	37	12	109194663	109194664	+	Frame_Shift_Del	DEL	AT	AT	-			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr12:109194663_109194664delAT	uc001tnm.2	-	12	1127_1128	c.1040_1041delAT	c.(1039-1041)AATfs	p.N347fs	SSH1_uc001tnl.2_Frame_Shift_Del_p.N35fs|SSH1_uc010sxg.1_Frame_Shift_Del_p.N358fs|SSH1_uc001tnn.3_Frame_Shift_Del_p.N347fs	NM_018984	NP_061857	Q8WYL5	SSH1_HUMAN	slingshot 1 isoform 1	347	Tyrosine-protein phosphatase.				actin cytoskeleton organization|cell morphogenesis|cellular response to ATP|regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of cellular protein metabolic process|regulation of lamellipodium assembly	cleavage furrow|cytoplasm|cytoskeleton|lamellipodium|midbody|plasma membrane	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(4)	4						CAGGAAAAAAATTATCGATTTC	0.351		NaN											NaN	NaN	NaN	NaN	NaN	36	98	---		---	---
LRRC16A	55604	broad.mit.edu	37	6	25551263	25551264	+	Frame_Shift_Ins	INS	-	-	A			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr6:25551263_25551264insA	uc011djw.1	+	27	2830_2831	c.2454_2455insA	c.(2452-2457)GTTAAAfs	p.V818fs	LRRC16A_uc010jpx.2_Frame_Shift_Ins_p.V818fs|LRRC16A_uc010jpy.2_Frame_Shift_Ins_p.V818fs|LRRC16A_uc003nfa.1_Frame_Shift_Ins_p.V172fs	NM_017640	NP_060110	Q5VZK9	LR16A_HUMAN	leucine rich repeat containing 16A	818_819					actin filament organization|blood coagulation|cell migration|lamellipodium assembly|ruffle organization|urate metabolic process	cytosol|lamellipodium|nucleus				ovary(1)|breast(1)|central_nervous_system(1)|pancreas(1)	4						GTACCTTTGTTAAAAATGTCCT	0.381		NaN											NaN	NaN	NaN	NaN	NaN	40	99	---		---	---
BCLAF1	9774	broad.mit.edu	37	6	136582545	136582545	+	Frame_Shift_Del	DEL	C	C	-			TCGA-GD-A3OS-01A-12D-A21Z-08	TCGA-GD-A3OS-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	9b3e164d-aaa0-4bb5-b7b8-6264b2746a47	257369d6-d4ac-4b67-8c30-de25dbdb76af	g.chr6:136582545delC	uc003qgx.1	-	12	2868	c.2615delG	c.(2614-2616)GGCfs	p.G872fs	BCLAF1_uc011edb.1_Frame_Shift_Del_p.G151fs|BCLAF1_uc003qgw.1_Frame_Shift_Del_p.G699fs|BCLAF1_uc003qgy.1_Frame_Shift_Del_p.G821fs|BCLAF1_uc011edc.1_RNA|BCLAF1_uc011edd.1_RNA|BCLAF1_uc011ede.1_Frame_Shift_Del_p.G870fs	NM_014739	NP_055554	Q9NYF8	BCLF1_HUMAN	BCL2-associated transcription factor 1 isoform	872					induction of apoptosis|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.00226)|OV - Ovarian serous cystadenocarcinoma(155;0.00331)		GCGCCCTCTGCCACGTTGAAA	0.428		NaN											NaN	NaN	NaN	NaN	NaN	81	282	---		---	---
