Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
CHEK2P2	0	broad.mit.edu	37	15	20496657	20496657	+	RNA	SNP	C	C	T	rs7180374	by1000genomes	TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr15:20496657C>T	ENST00000555186.1	+	0	710					NR_038836.1																						GACCACAAAGCGCCCGGCTGT	0.438000													8	174					0	0	1	0	0
CYP11B1	0	broad.mit.edu	37	8	143956706	143956706	+	Silent	SNP	G	G	A	rs138706121		TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr8:143956706G>A	ENST00000292427.4	-	7	1176	c.1144C>T	c.(1144-1146)Ctg>Ttg	p.L382L	CYP11B1_ENST00000377675.3_Silent_p.L453L|CYP11B1_ENST00000517471.1_Silent_p.L382L	NM_000497.3	NP_000488.3	P15538	C11B1_HUMAN	cytochrome P450, family 11, subfamily B, polypeptide 1	382					aldosterone biosynthetic process|cellular response to hormone stimulus|cellular response to potassium ion|cortisol biosynthetic process|glucose homeostasis|immune response|regulation of blood pressure|response to stress|xenobiotic metabolic process	mitochondrial inner membrane	electron carrier activity|steroid 11-beta-monooxygenase activity	p.L382L(1)		central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|lung(36)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(2)	67	all_cancers(97;4.74e-11)|all_epithelial(106;2.06e-08)|Lung NSC(106;0.000228)|all_lung(105;0.000633)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)				Mitotane(DB00648)	ACTCGCTCCAGAAACAGACCC	0.607000									Familial Hyperaldosteronism type I				9	213					0	0	1	0	0
PRB3	5544	broad.mit.edu	37	12	11420475	11420475	+	RNA	SNP	A	A	G			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr12:11420475A>G	ENST00000381842.3	-	0	642				PRB3_ENST00000538488.1_RNA|PRB3_ENST00000279573.6_RNA|PRB3_ENST00000440870.3_RNA	NM_006249.4	NP_006240.4	Q04118	PRB3_HUMAN	proline-rich protein BstNI subfamily 3							extracellular region	Gram-negative bacterial cell surface binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|skin(5)	25			OV - Ovarian serous cystadenocarcinoma(49;0.201)			GGGGACCTTGAGGTTTGTTGC	0.617000													8	52					0	0	1	0	0
GLUD1P2	0	broad.mit.edu	37	10	48968566	48968566	+	RNA	SNP	A	A	G			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr10:48968566A>G	ENST00000594520.1	+	0	723																											ACAGGATAACAAACTGGAAAA	0.318000													13	384					0	0	1	0	0
SLC6A13	6540	broad.mit.edu	37	12	347142	347142	+	Silent	SNP	G	G	T			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr12:347142G>T	ENST00000343164.4	-	5	565	c.513C>A	c.(511-513)tcC>tcA	p.S171S	SLC6A13_ENST00000445055.2_Silent_p.S79S	NM_016615.4	NP_057699.2	Q9NSD5	S6A13_HUMAN	solute carrier family 6 (neurotransmitter transporter), member 13	171					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(7)|lung(11)|prostate(1)|urinary_tract(1)	28	all_cancers(10;0.0416)|all_epithelial(11;0.0537)|all_lung(10;0.0989)|Lung NSC(10;0.139)|Ovarian(42;0.142)		OV - Ovarian serous cystadenocarcinoma(31;0.00153)|BRCA - Breast invasive adenocarcinoma(9;0.239)			TACCATTCAGGGAGCCGTTGG	0.522000													11	379					4.36969e-10	5.02514e-10	1	1	0
NPIPB11	728888	broad.mit.edu	37	16	29415043	29415043	+	Silent	SNP	G	G	A			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr16:29415043G>A	ENST00000524087.1	-	2	155	c.81C>T	c.(79-81)caC>caT	p.H27H	SNX29P2_ENST00000398878.3_lincRNA					nuclear pore complex interacting protein family, member B11									p.H27H(24)									CTGACTTTACGTGCTGCTGCA	0.577000													6	70					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593016	96593016	+	Missense_Mutation	SNP	C	C	A	rs79307257	by1000genomes	TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr2:96593016C>A	ENST00000456556.1	-	28	1969	c.1885G>T	c.(1885-1887)Gat>Tat	p.D629Y						ankyrin repeat domain 36C									p.D629Y(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						GAAACAGAATCTTTCTCATCA	0.318000													19	392					1.10923e-09	1.2445e-09	1	1	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22664743	22664743	+	RNA	SNP	G	G	A			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr22:22664743G>A	ENST00000426066.1	+	0	924					NR_027293.1																						CAGACTAAAGGCAAACAAGGA	0.498000													8	230					0	0	1	0	0
HLA-DQB2	3120	broad.mit.edu	37	6	32725653	32725653	+	Silent	SNP	C	C	T	rs144961216		TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr6:32725653C>T	ENST00000435145.2	-	4	715	c.654G>A	c.(652-654)caG>caA	p.Q218Q	HLA-DQB2_ENST00000411527.1_Intron|HLA-DQB2_ENST00000437316.2_Silent_p.Q218Q			Q5SR06	Q5SR06_HUMAN	major histocompatibility complex, class II, DQ beta 2	216					antigen processing and presentation of peptide or polysaccharide antigen via MHC class II|immune response	integral to membrane|MHC class II protein complex				endometrium(1)|kidney(1)|lung(1)|prostate(2)	5						CAGATTCAGACTGAGCCCCTA	0.557000													10	118					0	0	1	0	0
ZNF587B	100293516	broad.mit.edu	37	19	58352661	58352661	+	Missense_Mutation	SNP	T	T	A	rs148810844	by1000genomes	TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr19:58352661T>A	ENST00000442832.4	+	3	853	c.619T>A	c.(619-621)Ttt>Att	p.F207I	CTD-2583A14.10_ENST00000598031.1_Intron|ZNF587B_ENST00000594901.1_Missense_Mutation_p.F207I|ZNF587B_ENST00000316462.4_Intron	NM_001204818.1	NP_001191747.1	B4DR41	B4DR41_HUMAN	zinc finger protein 587B	207					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.F207I(1)									TGTGTCTCCCTTTCAGTGTGG	0.493000													15	260					0	0	1	0	0
HMGN2P46	0	broad.mit.edu	37	15	45848224	45848224	+	RNA	SNP	G	G	T			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr15:45848224G>T	ENST00000409454.1	+	0	1219																											TGCAGATTTTGTTTAGCTTTT	0.318000													30	123					1.03484e-13	1.2527e-13	1	1	0
KRTAP1-5	83895	broad.mit.edu	37	17	39183145	39183145	+	Missense_Mutation	SNP	A	A	G			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr17:39183145A>G	ENST00000361883.5	-	1	309	c.263T>C	c.(262-264)aTc>aCc	p.I88T		NM_031957.1	NP_114163.1	Q9BYS1	KRA15_HUMAN	keratin associated protein 1-5	88	15 X 5 AA repeats of C-C-[QEPVRC]- [TPIVLE]-[SRHVP].					keratin filament		p.I88T(11)		central_nervous_system(1)|endometrium(2)|kidney(1)|lung(9)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(2)	17		Breast(137;0.00043)	STAD - Stomach adenocarcinoma(17;0.000371)			GCAGGAGCTGATCTGGCAGCA	0.632000													15	287					0	0	1	0	0
OVCH1	341350	broad.mit.edu	37	12	29617500	29617500	+	Missense_Mutation	SNP	C	C	A			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr12:29617500C>A	ENST00000318184.5	-	18	2064	c.2065G>T	c.(2065-2067)Gca>Tca	p.A689S	OVCH1-AS1_ENST00000551108.1_Intron|OVCH1-AS1_ENST00000549411.1_Intron	NM_183378.2	NP_899234.2	Q7RTY7	OVCH1_HUMAN	ovochymase 1	689	Peptidase S1 2.				proteolysis	extracellular region	metal ion binding|serine-type endopeptidase activity			NS(2)|breast(4)|central_nervous_system(3)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(15)|lung(43)|ovary(5)|pancreas(3)|prostate(2)|skin(1)|soft_tissue(1)|stomach(3)	92	Lung NSC(12;1.84e-09)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)					AGAGGCTCTGCGCTGTGTGGG	0.463000													8	275					0.000157383	0.000164537	1	1	0
GNAS	2778	broad.mit.edu	37	20	57484420	57484420	+	Missense_Mutation	SNP	C	C	T	rs11554273		TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr20:57484420C>T	ENST00000371100.4	+	8	3082	c.2530C>T	c.(2530-2532)Cgt>Tgt	p.R844C	GNAS_ENST00000306090.10_Missense_Mutation_p.R187C|GNAS_ENST00000265620.7_Missense_Mutation_p.R186C|GNAS_ENST00000464624.2_3'UTR|GNAS_ENST00000371075.3_3'UTR|GNAS_ENST00000371085.3_Missense_Mutation_p.R201C|GNAS_ENST00000371095.3_Missense_Mutation_p.R187C|GNAS_ENST00000371102.4_Missense_Mutation_p.R830C|GNAS_ENST00000354359.7_Missense_Mutation_p.R202C|GNAS_ENST00000313949.7_3'UTR	NM_001077490.1|NM_080425.2	NP_001070958.1|NP_536350.2	P63092	GNAS2_HUMAN	GNAS complex locus	201					activation of adenylate cyclase activity|cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|intracellular transport|platelet activation|regulation of insulin secretion|sensory perception of smell|transmembrane transport|water transport	heterotrimeric G-protein complex|intrinsic to membrane|trans-Golgi network membrane	adenylate cyclase activity|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|identical protein binding|signal transducer activity	p.R201C(228)|p.R844C(9)|p.R201S(5)		adrenal_gland(12)|autonomic_ganglia(1)|biliary_tract(5)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(7)|large_intestine(37)|liver(9)|lung(9)|ovary(16)|pancreas(56)|parathyroid(5)|pituitary(228)|prostate(2)|small_intestine(1)|stomach(1)|testis(2)|thyroid(35)|upper_aerodigestive_tract(3)|urinary_tract(1)	441	all_lung(29;0.0104)		BRCA - Breast invasive adenocarcinoma(13;2.19e-08)|Colorectal(105;0.109)			GCTTCGCTGCCGTGTCCTGAC	0.428000			Mis		pituitary adenoma		"""McCune-Albright syndrome; pseudohypoparathyroidism, type IA"""			TSP Lung(22;0.16)			18	457					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593000	96593000	+	Missense_Mutation	SNP	A	A	G	rs111976783		TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr2:96593000A>G	ENST00000456556.1	-	28	1985	c.1901T>C	c.(1900-1902)aTa>aCa	p.I634T						ankyrin repeat domain 36C									p.I634T(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TTCTGTGGCTATATTTGAAAC	0.338000													19	410					0	0	1	0	0
RRN3P2	0	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													21	267					0	0	1	0	0
ANKRD36C	400986	broad.mit.edu	37	2	96593025	96593025	+	Missense_Mutation	SNP	C	C	T	rs75189823	by1000genomes	TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr2:96593025C>T	ENST00000456556.1	-	28	1960	c.1876G>A	c.(1876-1878)Gat>Aat	p.D626N						ankyrin repeat domain 36C									p.D626N(1)		breast(1)|endometrium(8)|kidney(5)|lung(4)	18						TCTTTCTCATCACTTGTAGCC	0.318000													19	389					0	0	1	0	0
CRYAB	1410	broad.mit.edu	37	11	111780950	111780950	+	Missense_Mutation	SNP	G	G	T			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr11:111780950G>T	ENST00000533971.1	-	2	516	c.425C>A	c.(424-426)cCa>cAa	p.P142Q	CRYAB_ENST00000526180.1_Intron|CRYAB_ENST00000525823.1_Intron|CRYAB_ENST00000227251.3_Intron|CRYAB_ENST00000533475.1_Intron|CRYAB_ENST00000533280.1_Intron|CRYAB_ENST00000527950.1_Intron|CRYAB_ENST00000531198.1_Intron			P02511	CRYAB_HUMAN	crystallin, alpha B	0					anti-apoptosis|muscle contraction|negative regulation of intracellular transport|protein folding|protein homooligomerization|response to heat	cytoplasm|nucleus	protein homodimerization activity|structural constituent of eye lens|unfolded protein binding			endometrium(1)|large_intestine(1)|lung(2)|skin(4)	8		all_cancers(61;1.26e-15)|all_epithelial(67;9.52e-10)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;3.57e-07)|BRCA - Breast invasive adenocarcinoma(274;1.1e-06)|all cancers(92;6.57e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.051)		GTTATGGCTTGGGACTGGAAT	0.418000													16	101					1.96292e-10	2.31524e-10	1	1	0
VAMP3	9341	broad.mit.edu	37	1	7838212	7838214	+	In_Frame_Del	DEL	TCA	TCA	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr1:7838212_7838214delTCA	ENST00000054666.6	+	4	381_383	c.266_268delTCA	c.(265-270)ttc>t	p.FI89del	VAMP3_ENST00000470357.1_In_Frame_Del_p.FI61del	NM_004781.3	NP_004772.1	Q15836	VAMP3_HUMAN	vesicle-associated membrane protein 3	89					cellular membrane fusion|positive regulation of receptor recycling|protein complex assembly|protein transport|retrograde transport, endosome to Golgi|substrate adhesion-dependent cell spreading|vesicle docking involved in exocytosis	cell junction|clathrin-coated vesicle|integral to membrane|recycling endosome|synapse|synaptosome	protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)	6	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;6.33e-69)|GBM - Glioblastoma multiforme(8;2.07e-34)|Colorectal(212;1.36e-07)|COAD - Colon adenocarcinoma(227;1.38e-05)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000805)|KIRC - Kidney renal clear cell carcinoma(229;0.000917)|STAD - Stomach adenocarcinoma(132;0.000985)|READ - Rectum adenocarcinoma(331;0.0642)		CTGGTTATCTTCATCATCATCAT	0.365													7	1363	---	---	---	---					
AADACL3	126767	broad.mit.edu	37	1	12785494	12785494	+	Frame_Shift_Del	DEL	G	G	-	rs7513079	by1000genomes	TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr1:12785494delG	ENST00000332530.3	+	3	600	c.374delG	c.(373-375)ttfs	p.C125fs	AADACL3_ENST00000359318.5_Frame_Shift_Del_p.C195fs	NM_001103169.1	NP_001096639.1	Q5VUY0	ADCL3_HUMAN	arylacetamide deacetylase-like 3	195							hydrolase activity			breast(1)|kidney(1)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(1)	15	Ovarian(185;0.249)	Lung NSC(185;8.27e-05)|all_lung(284;9.47e-05)|Renal(390;0.000147)|Colorectal(325;0.000583)|Breast(348;0.000596)|Ovarian(437;0.00965)|Hepatocellular(190;0.0245)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.13e-06)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0649)		ATCTGCTACTGTTTTTTTCAA	0.458													7	1526	---	---	---	---					
TCEB3	6924	broad.mit.edu	37	1	24078404	24078404	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr1:24078404delA	ENST00000418390.2	+	4	1658	c.1387delA	c.(1387-1389)aafs	p.K464fs		NM_003198.2	NP_003189.2	Q14241	ELOA1_HUMAN	transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)	464					positive regulation of viral transcription|regulation of transcription from RNA polymerase II promoter|transcription elongation from RNA polymerase II promoter|viral reproduction	integral to membrane	DNA binding	p.N439fs*19(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(2)|skin(1)	19		Colorectal(325;3.46e-05)|Lung NSC(340;0.000112)|all_lung(284;0.00016)|Renal(390;0.000219)|Breast(348;0.0044)|Ovarian(437;0.00539)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;2.42e-24)|Colorectal(126;5.5e-08)|COAD - Colon adenocarcinoma(152;3.09e-06)|GBM - Glioblastoma multiforme(114;4.74e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000973)|KIRC - Kidney renal clear cell carcinoma(1967;0.00334)|STAD - Stomach adenocarcinoma(196;0.0127)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.187)		TAAAGGACTTAAAAAAAATGA	0.413											OREG0013232	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	1137	---	---	---	---					
PHACTR4	65979	broad.mit.edu	37	1	28800272	28800273	+	Frame_Shift_Ins	INS	-	-	C			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr1:28800272_28800273insC	ENST00000373839.3	+	7	1291_1292	c.1030_1031insC	c.(1030-1032)cccfs	p.P344fs	PHACTR4_ENST00000493669.1_3'UTR|PHACTR4_ENST00000373836.3_Frame_Shift_Ins_p.P354fs	NM_001048183.1	NP_001041648.1	Q8IZ21	PHAR4_HUMAN	phosphatase and actin regulator 4	344	Pro-rich.						actin binding|protein phosphatase inhibitor activity	p.P356fs*33(1)		NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)		TCGCTCTCCGTCCCCCCCACTG	0.515													16	1410	---	---	---	---					
CCDC28B	79140	broad.mit.edu	37	1	32670247	32670248	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr1:32670247_32670248delTG	ENST00000421922.2	+	5	674_675	c.574_575delTG	c.(574-576)tfs	p.C192fs	CCDC28B_ENST00000373602.5_Intron|CCDC28B_ENST00000483009.1_Intron			Q9BUN5	CC28B_HUMAN	coiled-coil domain containing 28B	0										large_intestine(4)|lung(3)|ovary(1)|upper_aerodigestive_tract(2)	10		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				AACCCGTCTATGTGTGTGTGTT	0.500													22	1411	---	---	---	---					
ZMPSTE24	10269	broad.mit.edu	37	1	40756542	40756543	+	Frame_Shift_Ins	INS	-	-	T	rs137854889		TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr1:40756542_40756543insT	ENST00000372759.3	+	9	1241_1242	c.1076_1077insT	c.(1075-1077)tttfs	p.F359fs		NM_005857.4	NP_005848.2	O75844	FACE1_HUMAN	zinc metallopeptidase STE24	359						endoplasmic reticulum membrane|Golgi membrane|integral to membrane	metal ion binding|metalloexopeptidase activity			endometrium(3)|kidney(3)|large_intestine(4)|lung(4)|prostate(1)|skin(1)	16	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;6.3e-18)			TCTTTCCTGTGTTTTTTTTTAT	0.332													10	469	---	---	---	---					
PTPRF	5792	broad.mit.edu	37	1	44071946	44071948	+	In_Frame_Del	DEL	GCG	GCG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr1:44071946_44071948delGCG	ENST00000359947.4	+	20	3859_3861	c.3519_3521delGCG	c.(3517-3522)cag>ca	p.QR1173del	PTPRF_ENST00000372413.3_In_Frame_Del_p.QR1164del|PTPRF_ENST00000496447.1_3'UTR|PTPRF_ENST00000372414.3_In_Frame_Del_p.QR1173del|PTPRF_ENST00000438120.1_In_Frame_Del_p.QR1164del|PTPRF_ENST00000422171.2_In_Frame_Del_p.QR521del	NM_002840.3	NP_002831.2	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1173					transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(2)|breast(4)|central_nervous_system(3)|endometrium(9)|kidney(4)|large_intestine(11)|liver(1)|lung(24)|ovary(4)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)	72	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				GAGAGGAGCAGCGGCGGCGGCGG	0.631													9	831	---	---	---	---					
SLC6A9	6536	broad.mit.edu	37	1	44489938	44489938	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr1:44489938delT	ENST00000372310.3	-	2	177	c.12delA	c.(10-12)aafs	p.K4fs	SLC6A9_ENST00000372306.3_Frame_Shift_Del_p.K4fs|SLC6A9_ENST00000492434.2_5'UTR|SLC6A9_ENST00000475075.2_5'UTR|SLC6A9_ENST00000537678.1_5'UTR	NM_001024845.2	NP_001020016.1	P48067	SC6A9_HUMAN	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	335						integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			endometrium(3)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(2)	22	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	CTTTGGCACCTTTTCCTACCA	0.627													7	2124	---	---	---	---					
NDC1	55706	broad.mit.edu	37	1	54298190	54298192	+	In_Frame_Del	DEL	TTA	TTA	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr1:54298190_54298192delTTA	ENST00000371429.3	-	3	849_851	c.251_253delTAA	c.(250-255)agt>a	p.IS84del	NDC1_ENST00000537333.1_5'UTR|NDC1_ENST00000540001.1_In_Frame_Del_p.IS84del|NDC1_ENST00000480952.1_5'UTR|NDC1_ENST00000234725.8_5'UTR	NM_001168551.1|NM_018087.4	NP_001162023.1|NP_060557.3			NDC1 transmembrane nucleoporin																		TTGAAAATACTTATTATTATTAT	0.305													8	308	---	---	---	---					
RBMXL1	494115	broad.mit.edu	37	1	89448500	89448501	+	In_Frame_Ins	INS	-	-	CAT			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr1:89448500_89448501insCAT	ENST00000399794.2	-	3	1724_1725	c.1009_1010insATG	c.(1009-1011)ttg>ATGttg	p.336_337insM	RBMXL1_ENST00000321792.5_In_Frame_Ins_p.336_337insM|CCBL2_ENST00000370485.2_Intron|CCBL2_ENST00000446900.2_Intron|CCBL2_ENST00000260508.4_Intron|CCBL2_ENST00000370491.3_Intron	NM_001162536.2	NP_001156008.1	Q96E39	RBMXL_HUMAN	RNA binding motif protein, X-linked-like 1	336	Ser-rich.						nucleotide binding|RNA binding										CCTGTCACAACTTGAGTAGAGA	0.500													10	1766	---	---	---	---					
GBP5	115362	broad.mit.edu	37	1	89732166	89732166	+	Frame_Shift_Del	DEL	T	T	-	rs34148688		TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr1:89732166delT	ENST00000343435.5	-	7	1267	c.731delA	c.(730-732)agfs	p.K244fs	GBP5_ENST00000370459.3_Frame_Shift_Del_p.K244fs|GBP5_ENST00000481145.1_5'UTR|RP4-620F22.2_ENST00000437128.1_RNA	NM_001134486.2|NM_052942.3	NP_001127958.1|NP_443174.1	Q96PP8	GBP5_HUMAN	guanylate binding protein 5	244						plasma membrane	GTP binding|GTPase activity			breast(1)|endometrium(1)|large_intestine(6)|lung(14)|ovary(1)|prostate(1)	24				all cancers(265;0.00784)|Epithelial(280;0.0286)		TTGGGCAAGCTTTTTTTGGTG	0.388													11	1156	---	---	---	---					
BRDT	676	broad.mit.edu	37	1	92447228	92447230	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr1:92447228_92447230delAGC	ENST00000370389.2	+	12	2623_2625	c.1699_1701delAGC	c.(1699-1701)del	p.S575del	BRDT_ENST00000402388.1_In_Frame_Del_p.S648del|BRDT_ENST00000394530.3_In_Frame_Del_p.S602del|BRDT_ENST00000362005.3_In_Frame_Del_p.S648del|BRDT_ENST00000399546.2_In_Frame_Del_p.S648del	NM_001242810.1	NP_001229739.1	Q58F21	BRDT_HUMAN	bromodomain, testis-specific	648					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(24)|ovary(1)|prostate(4)|skin(2)|stomach(2)|urinary_tract(2)	56		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		ACTGAGTGAGagcagcagcagca	0.419													11	648	---	---	---	---					
SYCP1	6847	broad.mit.edu	37	1	115537600	115537601	+	Frame_Shift_Ins	INS	-	-	A			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr1:115537600_115537601insA	ENST00000369522.3	+	32	3131_3132	c.2891_2892insA	c.(2890-2892)aaafs	p.K964fs	SYCP1_ENST00000477590.1_3'UTR|SYCP1_ENST00000369518.1_Frame_Shift_Ins_p.K964fs	NM_003176.2	NP_003167.2	Q15431	SYCP1_HUMAN	synaptonemal complex protein 1	964	Arg/Lys-rich (basic).				cell division|reciprocal meiotic recombination|spermatogenesis|synaptonemal complex assembly		DNA binding		RGS22/SYCP1(2)	NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(17)|lung(20)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	48	Lung SC(450;0.211)	all_cancers(81;8.65e-08)|all_epithelial(167;3.32e-07)|all_lung(203;6.55e-06)|Lung NSC(69;1.11e-05)|Acute lymphoblastic leukemia(138;0.221)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		AAAATGGATAGAAAAAAAAAAC	0.356													19	410	---	---	---	---					
RP11-417J8.6	0	broad.mit.edu	37	1	142713977	142713977	+	RNA	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr1:142713977delT	ENST00000369381.2	-	0	628																											ATCCATATACTAAAAAGGTTA	0.294													14	99	---	---	---	---					
ANKRD35	148741	broad.mit.edu	37	1	145562117	145562117	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr1:145562117delA	ENST00000355594.4	+	10	1892	c.1805delA	c.(1804-1806)gafs	p.E602fs		NM_144698.3	NP_653299.3	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	602										NS(1)|biliary_tract(1)|central_nervous_system(1)|endometrium(7)|kidney(2)|large_intestine(9)|lung(16)|ovary(4)|prostate(3)|skin(2)|urinary_tract(1)	47	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CTTGGAGGGGAAAAGGCCCTA	0.577													8	565	---	---	---	---					
LINGO4	339398	broad.mit.edu	37	1	151773603	151773603	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr1:151773603delA	ENST00000368820.3	-	2	2515	c.1578delT	c.(1576-1578)ttfs	p.F526fs		NM_001004432.2	NP_001004432.1	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	526						integral to membrane				breast(2)|cervix(1)|endometrium(4)|large_intestine(5)|lung(4)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	21	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			TGCTATCCAGAAAAAAAGGCC	0.582													13	1346	---	---	---	---					
HAX1	10456	broad.mit.edu	37	1	154245864	154245866	+	In_Frame_Del	DEL	GAA	GAA	-	rs11556342		TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr1:154245864_154245866delGAA	ENST00000328703.7	+	2	319_321	c.106_108delGAA	c.(106-108)del	p.E40del	HAX1_ENST00000532105.1_Intron|HAX1_ENST00000483970.2_In_Frame_Del_p.E40del|HAX1_ENST00000457918.2_Intron	NM_006118.3	NP_006109.2	O00165	HAX1_HUMAN	HCLS1 associated protein X-1	40	Asp/Glu-rich (highly acidic).|Required for localization in mitochondria (By similarity).					actin cytoskeleton|cytoplasmic membrane-bounded vesicle|lamellipodium|mitochondrion|nuclear membrane|sarcoplasmic reticulum|soluble fraction	interleukin-1 binding|protein N-terminus binding			cervix(1)|endometrium(2)|large_intestine(2)|lung(8)|prostate(1)|upper_aerodigestive_tract(1)	15	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			TGATGATGAGGAAGAAGAAGAAG	0.522									Kostmann syndrome				19	489	---	---	---	---					
PRCC	5546	broad.mit.edu	37	1	156761535	156761536	+	Frame_Shift_Ins	INS	-	-	C			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr1:156761535_156761536insC	ENST00000271526.4	+	4	1402_1403	c.1130_1131insC	c.(1129-1131)gccfs	p.A377fs	PRCC_ENST00000491853.1_3'UTR|PRCC_ENST00000353233.3_Intron	NM_005973.4	NP_005964.3	Q92733	PRCC_HUMAN	papillary renal cell carcinoma (translocation-associated)	377					cell cycle|mitotic cell cycle checkpoint	nucleus	protein binding	p.Q380fs*12(1)	PRCC/TFE3(25)	breast(1)|central_nervous_system(3)|endometrium(1)|kidney(2)|large_intestine(1)|liver(1)|lung(5)|upper_aerodigestive_tract(1)	15	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					CCGGCCCTGGTCCCCCCCCAGG	0.530			T	TFE3	papillary renal								8	618	---	---	---	---					
DHX9	1660	broad.mit.edu	37	1	182845333	182845333	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr1:182845333delT	ENST00000367549.3	+	17	2074	c.1964delT	c.(1963-1965)gtfs	p.V655fs		NM_001357.4	NP_001348.2	Q08211	DHX9_HUMAN	DEAH (Asp-Glu-Ala-His) box helicase 9	655	Helicase C-terminal.				CRD-mediated mRNA stabilization|nuclear mRNA splicing, via spliceosome	centrosome|CRD-mediated mRNA stability complex|nucleolus|nucleoplasm|ribonucleoprotein complex	ATP binding|ATP-dependent DNA helicase activity|ATP-dependent RNA helicase activity|DNA binding|double-stranded RNA binding|protein binding			NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(10)|kidney(3)|large_intestine(7)|liver(1)|lung(19)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	49						GCTGTGTTGGTTTTTTTGCCT	0.378													8	1239	---	---	---	---					
PRG4	10216	broad.mit.edu	37	1	186276044	186276046	+	In_Frame_Del	DEL	CCA	CCA	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr1:186276044_186276046delCCA	ENST00000445192.2	+	7	1238_1240	c.1193_1195delCCA	c.(1192-1197)ccc>c	p.PT398del	PRG4_ENST00000367484.3_In_Frame_Del_p.PT357del|PRG4_ENST00000367486.3_In_Frame_Del_p.PT355del|PRG4_ENST00000367483.4_In_Frame_Del_p.PT357del|PRG4_ENST00000367485.4_In_Frame_Del_p.PT305del	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	398	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						GAGCCTGCACCCACCACCACCAA	0.650													7	958	---	---	---	---					
PRG4	10216	broad.mit.edu	37	1	186276374	186276376	+	In_Frame_Del	DEL	CCA	CCA	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr1:186276374_186276376delCCA	ENST00000445192.2	+	7	1568_1570	c.1523_1525delCCA	c.(1522-1527)ccc>c	p.PT508del	PRG4_ENST00000367484.3_Intron|PRG4_ENST00000367486.3_In_Frame_Del_p.PT465del|PRG4_ENST00000367483.4_In_Frame_Del_p.PT467del|PRG4_ENST00000367485.4_In_Frame_Del_p.PT415del	NM_005807.3	NP_005798.2	Q92954	PRG4_HUMAN	proteoglycan 4	508	59 X 8 AA repeats of K-X-P-X-P-T-T-X.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity	p.P508H(1)		NS(2)|breast(1)|central_nervous_system(1)|endometrium(26)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(12)|lung(33)|prostate(7)|skin(9)|upper_aerodigestive_tract(2)|urinary_tract(1)	102						GAGCCTGCACCCACCACCACCAA	0.645													7	1255	---	---	---	---					
GPR25	2848	broad.mit.edu	37	1	200842776	200842778	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr1:200842776_200842778delTGC	ENST00000304244.2	+	1	694_696	c.611_613delTGC	c.(610-615)ttg>t	p.LL208del		NM_005298.2	NP_005289.2	O00155	GPR25_HUMAN	G protein-coupled receptor 25	208	Poly-Leu.					integral to plasma membrane				large_intestine(1)|lung(2)|ovary(1)|skin(1)	5						GGCCTCAGCTTGCTGCTGCTGCT	0.724													8	185	---	---	---	---					
RPS10P7	0	broad.mit.edu	37	1	201489731	201489731	+	RNA	DEL	G	G	-	rs4915234	by1000genomes	TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr1:201489731delG	ENST00000441932.1	+	0	1901				RP11-134G8.7_ENST00000454651.1_RNA	NR_026667.1																						AAAAAaaaaagaaagaaagct	0.423													13	23	---	---	---	---					
IPO9	55705	broad.mit.edu	37	1	201843998	201844000	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr1:201843998_201844000delGAG	ENST00000361565.4	+	22	2941_2943	c.2872_2874delGAG	c.(2872-2874)del	p.E962del		NM_018085.4	NP_060555.2	Q96P70	IPO9_HUMAN	importin 9	962					protein import into nucleus	cytoplasm|nucleus	histone binding|protein transporter activity			cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	38						ggaggaggaagaggaggaggagg	0.443													11	723	---	---	---	---					
DYRK3	8444	broad.mit.edu	37	1	206821441	206821441	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr1:206821441delA	ENST00000367106.1	+	4	1311	c.838delA	c.(838-840)aafs	p.K281fs	DYRK3_ENST00000367109.2_Frame_Shift_Del_p.K301fs|DYRK3_ENST00000367108.3_Frame_Shift_Del_p.K281fs|DYRK3_ENST00000489878.1_Intron			O43781	DYRK3_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3	301	Protein kinase.				erythrocyte differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(9)|lung(8)|skin(1)|stomach(2)	25	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			TGAGCTGATTAAAAAAAATAA	0.403													7	976	---	---	---	---					
MAPKAPK2	9261	broad.mit.edu	37	1	206858676	206858678	+	In_Frame_Del	DEL	GCC	GCC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr1:206858676_206858678delGCC	ENST00000367103.3	+	1	295_297	c.102_104delGCC	c.(100-105)cag>ca	p.QP34del	MAPKAPK2_ENST00000294981.4_In_Frame_Del_p.QP34del	NM_004759.4|NM_032960.3	NP_004750.1|NP_116584.2	P49137	MAPK2_HUMAN	mitogen-activated protein kinase-activated protein kinase 2	34	Pro-rich.				activation of MAPK activity|hormone biosynthetic process|innate immune response|leukotriene biosynthetic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|prostanoid metabolic process|Ras protein signal transduction|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|signal transducer activity			central_nervous_system(1)|endometrium(1)|large_intestine(4)|lung(8)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	19	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.211)			ccccggcgcagccgccgccgccg	0.729													9	64	---	---	---	---					
ARV1	64801	broad.mit.edu	37	1	231131567	231131567	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr1:231131567delA	ENST00000310256.2	+	4	567	c.510delA	c.(508-510)gcfs	p.A170fs	ARV1_ENST00000497753.1_3'UTR|ARV1_ENST00000366658.2_Frame_Shift_Del_p.A130fs	NM_022786.1	NP_073623.1	Q9H2C2	ARV1_HUMAN	ARV1 homolog (S. cerevisiae)	170					sphingolipid metabolic process	integral to membrane				breast(3)|large_intestine(2)|lung(2)	7	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.178)		COAD - Colon adenocarcinoma(196;0.211)|Colorectal(1306;0.233)		CCATGACGGCAAAAAAAAAGC	0.383													16	484	---	---	---	---					
ATP6V1C2	245973	broad.mit.edu	37	2	10917819	10917820	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr2:10917819_10917820delAG	ENST00000272238.4	+	11	1043_1044	c.934_935delAG	c.(934-936)afs	p.R312fs	ATP6V1C2_ENST00000381661.3_Intron	NM_001039362.1	NP_001034451.1	Q8NEY4	VATC2_HUMAN	ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2	312					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|proton-transporting V-type ATPase, V1 domain				endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.15)|OV - Ovarian serous cystadenocarcinoma(76;0.152)		GCAGACCGACAGAGAGAGAGAG	0.604													16	646	---	---	---	---					
APOB	338	broad.mit.edu	37	2	21228602	21228602	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr2:21228602delT	ENST00000233242.1	-	26	11265	c.11138delA	c.(11137-11139)acfs	p.N3713fs		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	3713					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GCCATTGGGGTTTTTGGTGTA	0.398													8	935	---	---	---	---					
ASXL2	55252	broad.mit.edu	37	2	26022304	26022306	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr2:26022304_26022306delCTG	ENST00000435504.4	-	5	644_646	c.351_353delCAG	c.(349-354)agt>ag	p.SS117del	ASXL2_ENST00000497092.1_5'UTR|ASXL2_ENST00000336112.4_In_Frame_Del_p.SS89del|ASXL2_ENST00000272341.4_5'UTR			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	117	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCCACCATCACTGCTGCTGCTGC	0.463													8	905	---	---	---	---					
OTOF	9381	broad.mit.edu	37	2	26693554	26693556	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr2:26693554_26693556delCTT	ENST00000272371.2	-	32	4054_4056	c.3928_3930delAAG	c.(3928-3930)del	p.K1310del	OTOF_ENST00000402415.3_In_Frame_Del_p.K620del|OTOF_ENST00000403946.3_In_Frame_Del_p.K1310del|OTOF_ENST00000338581.6_In_Frame_Del_p.K543del|OTOF_ENST00000339598.3_In_Frame_Del_p.K543del	NM_194248.2	NP_919224.1	Q9HC10	OTOF_HUMAN	otoferlin	1310	Poly-Lys.				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|breast(9)|central_nervous_system(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(35)|ovary(8)|pancreas(1)|prostate(5)|skin(5)|stomach(4)|upper_aerodigestive_tract(3)|urinary_tract(1)	106	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CCGCAGTGCCcttcttcttcttc	0.576													7	525	---	---	---	---					
C2orf71	388939	broad.mit.edu	37	2	29295647	29295649	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr2:29295647_29295649delTCC	ENST00000331664.5	-	1	1478_1480	c.1479_1481delGGA	c.(1477-1482)gaa>ga	p.EE493del		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	493					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						CATTTTGTCTTCCTCCTCCTCCT	0.542													11	1006	---	---	---	---					
CEBPZ	10153	broad.mit.edu	37	2	37454908	37454908	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr2:37454908delT	ENST00000234170.5	-	2	1573	c.1428delA	c.(1426-1428)aafs	p.K476fs		NM_005760.2	NP_005751.2	Q03701	CEBPZ_HUMAN	CCAAT/enhancer binding protein (C/EBP), zeta	476					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding			breast(3)|endometrium(2)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	28		all_hematologic(82;0.21)				ATTCAACATCTTTTTTTTTGA	0.368													15	341	---	---	---	---					
ZFP36L2	678	broad.mit.edu	37	2	43452520	43452522	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr2:43452520_43452522delCTG	ENST00000282388.3	-	2	714_716	c.421_423delCAG	c.(421-423)del	p.Q141del	THADA_ENST00000330266.7_Intron	NM_006887.4	NP_008818.3	P47974	TISD_HUMAN	ZFP36 ring finger protein-like 2	141	Poly-Gln.				cell proliferation	nucleus	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|upper_aerodigestive_tract(1)	15		Acute lymphoblastic leukemia(82;0.00323)|all_hematologic(82;0.00824)				CGCCCCCCTTCTGCTGCTGCTGC	0.645													8	208	---	---	---	---					
OTX1	5013	broad.mit.edu	37	2	63283259	63283261	+	In_Frame_Del	DEL	CCA	CCA	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr2:63283259_63283261delCCA	ENST00000282549.2	+	5	1149_1151	c.873_875delCCA	c.(871-876)ggc>gg	p.GH291del	OTX1_ENST00000366671.3_In_Frame_Del_p.GH291del	NM_014562.3	NP_055377.1	P32242	OTX1_HUMAN	orthodenticle homeobox 1	291	His-rich.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(1)|kidney(2)|large_intestine(6)|lung(6)|pancreas(2)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	20	Lung NSC(7;0.121)|all_lung(7;0.211)					AGTCCTCAGGccaccaccaccac	0.640													8	625	---	---	---	---					
SLC4A5	57835	broad.mit.edu	37	2	74451994	74451994	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr2:74451994delT	ENST00000394019.2	-	28	3616	c.3219delA	c.(3217-3219)aafs	p.K1073fs	SLC4A5_ENST00000483195.1_5'UTR|SLC4A5_ENST00000377632.1_Frame_Shift_Del_p.K992fs|SLC4A5_ENST00000357822.5_Frame_Shift_Del_p.K1089fs|SLC4A5_ENST00000377634.4_Frame_Shift_Del_p.K1089fs|SLC4A5_ENST00000358683.4_Frame_Shift_Del_p.K971fs|SLC4A5_ENST00000359484.4_Frame_Shift_Del_p.K971fs|SLC4A5_ENST00000346834.4_Frame_Shift_Del_p.K992fs|SLC4A5_ENST00000423644.1_3'UTR|RP11-287D1.3_ENST00000451608.2_3'UTR	NM_133478.2	NP_597812.1	Q9BY07	S4A5_HUMAN	solute carrier family 4 (sodium bicarbonate cotransporter), member 5	1089						apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			breast(5)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(12)|lung(13)|ovary(5)|pancreas(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	48						CGTGGGCCCCTTTTTTTCTCT	0.517													8	1239	---	---	---	---					
AC027612.3	0	broad.mit.edu	37	2	91887905	91887906	+	RNA	INS	-	-	T			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr2:91887905_91887906insT	ENST00000436174.1	-	0	540																											GCTATTTTCCATTTTTTTTTTT	0.292													12	283	---	---	---	---					
TMEM127	55654	broad.mit.edu	37	2	96919781	96919783	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr2:96919781_96919783delTGC	ENST00000258439.2	-	4	736_738	c.480_482delGCA	c.(478-483)cat>ca	p.QH160del	TMEM127_ENST00000435268.1_In_Frame_Del_p.QH76del|TMEM127_ENST00000432959.1_In_Frame_Del_p.QH160del	NM_001193304.2|NM_017849.3	NP_001180233.1|NP_060319.1	O75204	TM127_HUMAN	transmembrane protein 127	160					negative regulation of cell proliferation|negative regulation of TOR signaling cascade	cytoplasm|integral to membrane|plasma membrane				endometrium(1)|large_intestine(1)|lung(1)|prostate(1)|stomach(1)	5						GTACTTCTTATGCTGCTGCTGCT	0.557													9	698	---	---	---	---					
TMEM131	23505	broad.mit.edu	37	2	98427639	98427639	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr2:98427639delT	ENST00000186436.5	-	18	2148	c.1920delA	c.(1918-1920)aafs	p.K640fs		NM_015348.1	NP_056163.1	Q92545	TM131_HUMAN	transmembrane protein 131	640						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(4)|prostate(1)|skin(1)|stomach(1)	57						TCCCCTCTAATTTTTTTGCAG	0.393													14	1664	---	---	---	---					
LIPT1	51601	broad.mit.edu	37	2	99778781	99778781	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr2:99778781delA	ENST00000393477.3	+	4	713	c.361delA	c.(361-363)aafs	p.K123fs	LIPT1_ENST00000393473.2_Frame_Shift_Del_p.K123fs|LIPT1_ENST00000393474.3_Frame_Shift_Del_p.K123fs|LIPT1_ENST00000340066.1_Frame_Shift_Del_p.K123fs|LIPT1_ENST00000393471.2_Frame_Shift_Del_p.K123fs|MRPL30_ENST00000410042.1_Intron	NM_145197.2	NP_660198.1	Q9Y234	LIPT_HUMAN	lipoyltransferase 1	123					lipid metabolic process|protein lipoylation	mitochondrion	acyltransferase activity			large_intestine(6)|lung(1)	7					Lipoic Acid(DB00166)	CTTTACAACCAAAAAAAAGTA	0.388													9	521	---	---	---	---					
EIF5B	9669	broad.mit.edu	37	2	99977775	99977777	+	In_Frame_Del	DEL	TGA	TGA	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr2:99977775_99977777delTGA	ENST00000289371.5	+	4	613_615	c.411_413delTGA	c.(409-414)agt>ag	p.SD137del		NM_015904.3	NP_056988.3	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	137					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(13)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						ACTCTGGGAGTGATGATGATGAT	0.345													8	675	---	---	---	---					
SULT1C3	442038	broad.mit.edu	37	2	108863685	108863685	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr2:108863685delA	ENST00000329106.2	+	1	35	c.35delA	c.(34-36)gafs	p.E12fs	SULT1C3_ENST00000376700.1_Frame_Shift_Del_p.E12fs	NM_001008743.1	NP_001008743.1	Q6IMI6	ST1C3_HUMAN	sulfotransferase family, cytosolic, 1C, member 3	12						cytoplasm	alcohol sulfotransferase activity			breast(1)|kidney(1)|large_intestine(1)|lung(8)|prostate(1)|skin(4)	16						CCCACGATGGAAAAAAAGCCA	0.353													7	755	---	---	---	---					
NPHP1	4867	broad.mit.edu	37	2	110922711	110922713	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr2:110922711_110922713delCTT	ENST00000316534.4	-	7	717_719	c.644_646delAAG	c.(643-648)ggc>g	p.EG215del	NPHP1_ENST00000393272.3_In_Frame_Del_p.EG215del|NPHP1_ENST00000445609.2_In_Frame_Del_p.EG215del|NPHP1_ENST00000417665.1_In_Frame_Del_p.EG215del|NPHP1_ENST00000355301.4_In_Frame_Del_p.EG153del			O15259	NPHP1_HUMAN	nephronophthisis 1 (juvenile)	215	Glu-rich.				actin cytoskeleton organization|cell projection organization|cell-cell adhesion|excretion|retina development in camera-type eye|signal transduction|spermatid differentiation|visual behavior	adherens junction|cell-cell junction|cilium axoneme|cytoplasm|cytoskeleton|motile cilium|photoreceptor connecting cilium	protein binding|structural molecule activity			autonomic_ganglia(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|lung(10)|ovary(2)	24						GACTCTTGGCCTTCTTCTTCTTC	0.404													7	852	---	---	---	---					
WDR33	55339	broad.mit.edu	37	2	128476956	128476956	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr2:128476956delG	ENST00000322313.4	-	16	2801	c.2643delC	c.(2641-2643)ccfs	p.P881fs		NM_018383.4	NP_060853.3	Q9C0J8	WDR33_HUMAN	WD repeat domain 33	881					postreplication repair|spermatogenesis	collagen|nucleus	protein binding			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(9)|lung(17)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	39	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0695)		CCTGAGGTCCGGGGGGTCCTT	0.627													7	839	---	---	---	---					
CIR1	9541	broad.mit.edu	37	2	175213713	175213713	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr2:175213713delT	ENST00000342016.3	-	10	957	c.865delA	c.(865-867)tafs	p.I289fs	CIR1_ENST00000362053.5_3'UTR	NM_004882.3	NP_004873.3	Q86X95	CIR1_HUMAN	corepressor interacting with RBPJ, 1	289	Lys/Ser-rich.				mRNA processing|negative regulation of transcription, DNA-dependent|RNA splicing	nuclear speck	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|endometrium(3)|large_intestine(5)|lung(5)|skin(1)	15						ttcctttgtatttttttttct	0.383													8	402	---	---	---	---					
SGOL2	151246	broad.mit.edu	37	2	201437003	201437004	+	Frame_Shift_Ins	INS	-	-	T			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr2:201437003_201437004insT	ENST00000357799.4	+	7	2032_2033	c.1934_1935insT	c.(1933-1935)attfs	p.I645fs		NM_001160033.1|NM_001160046.1|NM_152524.5	NP_001153505.1|NP_001153518.1|NP_689737.4	Q562F6	SGOL2_HUMAN	shugoshin-like 2 (S. pombe)	645					cell division|mitotic prometaphase	condensed chromosome kinetochore|cytosol|mitotic cohesin complex	protein binding			NS(2)|breast(2)|cervix(3)|endometrium(1)|kidney(2)|large_intestine(7)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	46						AAAAAAGGTAATTTTTTTTTCA	0.337													9	871	---	---	---	---					
ALS2CR11	151254	broad.mit.edu	37	2	202352352	202352352	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr2:202352352delT	ENST00000439140.1	-	16	5490	c.5446delA	c.(5446-5448)ttfs	p.I1816fs	ALS2CR11_ENST00000286195.3_Frame_Shift_Del_p.I619fs|ALS2CR11_ENST00000439802.1_3'UTR	NM_001168221.1	NP_001161693.1	Q53TS8	AL2SA_HUMAN	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11	619										NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(11)|ovary(1)|skin(5)|urinary_tract(3)	33						CCTCTTTTAATTTTTTTTGGC	0.323													9	589	---	---	---	---					
SLC4A3	6508	broad.mit.edu	37	2	220496799	220496801	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr2:220496799_220496801delGAA	ENST00000358055.3	+	7	1433_1435	c.921_923delGAA	c.(919-924)agg>ag	p.RK307del	SLC4A3_ENST00000373760.2_In_Frame_Del_p.RK307del|SLC4A3_ENST00000373762.3_In_Frame_Del_p.RK334del|SLC4A3_ENST00000273063.6_In_Frame_Del_p.RK334del|SLC4A3_ENST00000497589.1_3'UTR|SLC4A3_ENST00000317151.3_In_Frame_Del_p.RK307del			P48751	B3A3_HUMAN	solute carrier family 4 (anion exchanger), member 3	307					bicarbonate transport	integral to plasma membrane|membrane fraction	inorganic anion exchanger activity			breast(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	51		Renal(207;0.0183)		Epithelial(149;2.53e-07)|all cancers(144;5.57e-05)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		TCCTTCGCAGGAAGAAGAAGAAG	0.650													7	502	---	---	---	---					
USP40	55230	broad.mit.edu	37	2	234394236	234394237	+	Frame_Shift_Ins	INS	-	-	T			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr2:234394236_234394237insT	ENST00000251722.6	-	30	3558_3559	c.3441_3442insA	c.(3439-3444)aaaagafs	p.R1148fs	USP40_ENST00000496298.1_5'UTR|USP40_ENST00000450966.1_Frame_Shift_Ins_p.R1160fs|USP40_ENST00000427112.2_Frame_Shift_Ins_p.R1148fs			Q9NVE5	UBP40_HUMAN	ubiquitin specific peptidase 40	1148					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			breast(1)|endometrium(6)|kidney(5)|large_intestine(5)|lung(10)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	30		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0539)		Epithelial(121;1.71e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000407)|Lung(119;0.00277)|LUSC - Lung squamous cell carcinoma(224;0.00646)		AAATAATCTTGTTTTTTTTTCT	0.337													8	238	---	---	---	---					
GAL3ST2	64090	broad.mit.edu	37	2	242738494	242738496	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr2:242738494_242738496delTCC	ENST00000192314.6	+	2	175_177	c.44_46delTCC	c.(43-48)atc>a	p.IL15del		NM_022134.2	NP_071417.2	Q9H3Q3	G3ST2_HUMAN	galactose-3-O-sulfotransferase 2	15					biosynthetic process	Golgi cisterna membrane|integral to membrane	galactosylceramide sulfotransferase activity	p.L16I(1)		endometrium(1)|kidney(1)|large_intestine(1)|lung(9)|prostate(1)|skin(1)	14		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;4.59e-33)|all cancers(36;9.89e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.89e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0833)		TTCCGGGTCATCCTCCTCCTCCT	0.631													14	510	---	---	---	---					
EDEM1	9695	broad.mit.edu	37	3	5248941	5248941	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr3:5248941delT	ENST00000256497.4	+	7	1454	c.1321delT	c.(1321-1323)ttfs	p.F442fs	EDEM1_ENST00000445686.1_Frame_Shift_Del_p.F247fs	NM_014674.2	NP_055489.1	Q92611	EDEM1_HUMAN	ER degradation enhancer, mannosidase alpha-like 1	442					ER-associated protein catabolic process|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|response to unfolded protein	integral to endoplasmic reticulum membrane	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity|misfolded protein binding			NS(1)|breast(1)|endometrium(1)|large_intestine(5)|liver(2)|lung(4)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	22				Epithelial(13;0.0588)|OV - Ovarian serous cystadenocarcinoma(96;0.0682)		TCTGCAGGCCTTTTTCCCTGG	0.463													7	889	---	---	---	---					
TMEM40	55287	broad.mit.edu	37	3	12790198	12790200	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr3:12790198_12790200delGAG	ENST00000314124.7	-	3	521_523	c.165_167delCTC	c.(163-168)tct>tc	p.SS69del	TMEM40_ENST00000431022.2_In_Frame_Del_p.SS85del|TMEM40_ENST00000435575.1_Intron|TMEM40_ENST00000435218.2_In_Frame_Del_p.SS69del|TMEM40_ENST00000264728.8_In_Frame_Del_p.SS69del	NM_018306.2	NP_060776.2	Q8WWA1	TMM40_HUMAN	transmembrane protein 40	69	Ser-rich.					integral to membrane				breast(1)|large_intestine(3)|lung(5)|urinary_tract(1)	10						tgaggaggaagaggaggaggagg	0.419													7	1151	---	---	---	---					
XPC	7508	broad.mit.edu	37	3	14219966	14219968	+	Splice_Site	DEL	CCT	CCT	-	rs72561774		TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr3:14219966_14219968delCCT	ENST00000285021.7	-	1	315_317	c.103_splice	c.e1+1	p.ED34_splice	LSM3_ENST00000306024.3_5'UTR|XPC_ENST00000449060.2_Splice_Site_p.ED34_splice	NM_001145769.1|NM_004628.4	NP_001139241.1|NP_004619.3	Q01831	XPC_HUMAN	xeroderma pigmentosum, complementation group C	34	Glu-rich (acidic).|Poly-Glu.				nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal	cytoplasm|nucleoplasm|XPC complex	bubble DNA binding|damaged DNA binding|loop DNA binding|protein binding|single-stranded DNA binding	p.E34delE(1)		NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22						TCGCTCTCACCCTCCTCCTCCTC	0.734			"""Mis, N, F, S"""			"""skin basal cell, skin squamous cell, melanoma"""		Nucleotide excision repair (NER)	Xeroderma Pigmentosum				16	397	---	---	---	---					
SATB1	6304	broad.mit.edu	37	3	18391133	18391135	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr3:18391133_18391135delCTG	ENST00000338745.6	-	11	3553_3555	c.1819_1821delCAG	c.(1819-1821)del	p.Q607del	SATB1_ENST00000417717.2_In_Frame_Del_p.Q639del|SATB1_ENST00000454909.2_In_Frame_Del_p.Q607del|TBC1D5_ENST00000414318.2_Intron	NM_002971.4	NP_002962.1	Q01826	SATB1_HUMAN	SATB homeobox 1	607	Poly-Gln.				cellular component disassembly involved in apoptosis|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter	nuclear matrix|PML body	double-stranded DNA binding|sequence-specific DNA binding			NS(2)|breast(2)|endometrium(6)|large_intestine(4)|lung(10)|ovary(1)|skin(5)|upper_aerodigestive_tract(2)	32						GCGGCGGTGCctgctgctgctgc	0.606													8	187	---	---	---	---					
SGOL1	151648	broad.mit.edu	37	3	20216050	20216050	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr3:20216050delT	ENST00000412997.1	-	6	1324	c.973delA	c.(973-975)tgfs	p.M325fs	SGOL1_ENST00000306698.2_Intron|SGOL1-AS1_ENST00000448208.1_RNA|SGOL1-AS1_ENST00000441442.1_RNA|SGOL1_ENST00000421451.1_Frame_Shift_Del_p.M325fs|SGOL1_ENST00000425061.1_Intron|SGOL1_ENST00000417364.1_Intron|SGOL1_ENST00000442720.1_Intron|SGOL1_ENST00000443724.1_Intron|SGOL1_ENST00000452020.1_Intron|SGOL1_ENST00000263753.4_Frame_Shift_Del_p.M325fs|SGOL1_ENST00000429446.3_Intron|SGOL1_ENST00000412868.1_Frame_Shift_Del_p.M325fs|SGOL1_ENST00000419233.2_Intron|SGOL1_ENST00000437051.1_Intron|SGOL1_ENST00000383774.1_Intron	NM_001199251.1	NP_001186180.1	Q5FBB7	SGOL1_HUMAN	shugoshin-like 1 (S. pombe)	325					attachment of spindle microtubules to kinetochore|cell division|centriole-centriole cohesion|meiotic chromosome segregation|mitotic prometaphase	centrosome|condensed chromosome kinetochore|cytosol|mitotic cohesin complex|spindle pole	protein binding			kidney(1)|large_intestine(4)|lung(6)|skin(1)|urinary_tract(2)	14						GATTTGTGCATTTTTTTTTGG	0.318													13	262	---	---	---	---					
CDCP1	64866	broad.mit.edu	37	3	45127479	45127479	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr3:45127479delT	ENST00000296129.1	-	9	2296	c.2162delA	c.(2161-2163)agfs	p.K721fs		NM_022842.3	NP_073753.3	Q9H5V8	CDCP1_HUMAN	CUB domain containing protein 1	721						extracellular region|integral to membrane|plasma membrane				central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|skin(4)|urinary_tract(1)	29				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		TTTCTGAAACTTTTTTGGCTG	0.468													7	1845	---	---	---	---					
USP4	7375	broad.mit.edu	37	3	49321969	49321971	+	In_Frame_Del	DEL	TCT	TCT	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr3:49321969_49321971delTCT	ENST00000351842.4	-	17	2185_2187	c.2177_2179delAGA	c.(2176-2181)acc>a	p.KT726del	USP4_ENST00000265560.4_In_Frame_Del_p.KT773del	NM_199443.2	NP_955475.1	Q13107	UBP4_HUMAN	ubiquitin specific peptidase 4 (proto-oncogene)	773					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		GCCACTGTGGTCTTCTTCTTCTT	0.532													8	892	---	---	---	---					
VGLL3	389136	broad.mit.edu	37	3	87027857	87027859	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr3:87027857_87027859delCTC	ENST00000398399.2	-	2	583_585	c.220_222delGAG	c.(220-222)del	p.E74del	VGLL3_ENST00000383698.3_In_Frame_Del_p.E74del	NM_016206.2	NP_057290.2	A8MV65	VGLL3_HUMAN	vestigial like 3 (Drosophila)	74					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(11)	19	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		GCTGGtctttctcctcctcctcc	0.502													9	324	---	---	---	---					
RP11-325B23.2	0	broad.mit.edu	37	3	98031434	98031434	+	RNA	DEL	A	A	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr3:98031434delA	ENST00000508616.1	+	0	149				OR5H8P_ENST00000394191.2_RNA																							TTACAATCTTAAAAAAAAAAG	0.333													7	199	---	---	---	---					
RP11-167H9.4	0	broad.mit.edu	37	3	149769296	149769296	+	RNA	DEL	C	C	-	rs59377959		TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr3:149769296delC	ENST00000487840.1	+	0	46																											TTCCTGGTGTCtttttttttt	0.463													11	474	---	---	---	---					
PHC3	80012	broad.mit.edu	37	3	169896635	169896637	+	In_Frame_Del	DEL	TGG	TGG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr3:169896635_169896637delTGG	ENST00000494943.1	-	2	136_138	c.68_70delCCA	c.(67-72)atc>a	p.TI23del	PHC3_ENST00000497658.1_In_Frame_Del_p.TI35del|PHC3_ENST00000474275.1_In_Frame_Del_p.TI23del|PHC3_ENST00000495893.1_In_Frame_Del_p.TI35del|PHC3_ENST00000481639.1_In_Frame_Del_p.TI35del|PHC3_ENST00000467570.1_In_Frame_Del_p.TI35del			Q8NDX5	PHC3_HUMAN	polyhomeotic homolog 3 (Drosophila)	23	Poly-Thr.				multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(12)|ovary(1)|upper_aerodigestive_tract(2)	26	all_cancers(22;2.67e-22)|all_epithelial(15;4.73e-27)|all_lung(20;6.31e-17)|Lung NSC(18;2.61e-16)|Ovarian(172;0.000337)|Breast(254;0.169)		Lung(28;2.71e-13)|STAD - Stomach adenocarcinoma(35;0.0655)			GAAgtggtgatggtggtggtggt	0.493													12	1711	---	---	---	---					
TMEM175	84286	broad.mit.edu	37	4	946206	946207	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr4:946206_946207delTG	ENST00000264771.4	+	7	615_616	c.430_431delTG	c.(430-432)tfs	p.C144fs	TMEM175_ENST00000515740.1_Frame_Shift_Del_p.C28fs|TMEM175_ENST00000504180.1_3'UTR|TMEM175_ENST00000508204.1_Frame_Shift_Del_p.C62fs	NM_032326.2	NP_115702.1	Q9BSA9	TM175_HUMAN	transmembrane protein 175	144						integral to membrane				NS(1)|endometrium(1)|large_intestine(2)|lung(6)|pancreas(1)|upper_aerodigestive_tract(3)	14			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			CTTCTTGTTCTGTGTGTGTGTG	0.515													12	1305	---	---	---	---					
WHSC1	7468	broad.mit.edu	37	4	1980558	1980559	+	Frame_Shift_Ins	INS	-	-	C			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr4:1980558_1980559insC	ENST00000382895.3	+	24	4451_4452	c.4020_4021insC	c.(4018-4023)aaccccfs	p.NP1340fs	WHSC1_ENST00000508803.1_Frame_Shift_Ins_p.NP1340fs|WHSC1_ENST00000482415.2_3'UTR|WHSC1_ENST00000382888.3_Frame_Shift_Ins_p.NP688fs|WHSC1_ENST00000382891.5_Frame_Shift_Ins_p.NP1340fs|WHSC1_ENST00000382892.2_Frame_Shift_Ins_p.NP1340fs	NM_133330.2	NP_579877.1	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1	1340					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(10)|lung(14)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	48		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		AGACTGAGAAGCCCCCCCCAGA	0.678			T	IGH@	MM								7	242	---	---	---	---					
OTOP1	133060	broad.mit.edu	37	4	4204225	4204229	+	Frame_Shift_Del	DEL	TTGAG	TTGAG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr4:4204225_4204229delTTGAG	ENST00000296358.4	-	4	700_704	c.676_680delCTCAA	c.(676-681)tfs	p.LN226fs		NM_177998.1	NP_819056.1	Q7RTM1	OTOP1_HUMAN	otopetrin 1	226					biomineral tissue development	extracellular space|integral to membrane		p.L226fs*1(1)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(3)|liver(4)|lung(14)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	34				UCEC - Uterine corpus endometrioid carcinoma (64;0.168)		CTTGTGCTCATTGAGTTGGTGCTTT	0.502													15	765	---	---	---	---					
CPEB2	132864	broad.mit.edu	37	4	15067858	15067858	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr4:15067858delT	ENST00000538197.1	+	12	2959	c.2959delT	c.(2959-2961)ttfs	p.F988fs	CPEB2_ENST00000442003.2_Frame_Shift_Del_p.F961fs|CPEB2_ENST00000541112.1_Frame_Shift_Del_p.F980fs|RP11-665G4.1_ENST00000513384.1_RNA|CPEB2_ENST00000259997.5_Frame_Shift_Del_p.F551fs|CPEB2_ENST00000507071.1_Frame_Shift_Del_p.F543fs|RP11-665G4.1_ENST00000502344.1_RNA|CPEB2_ENST00000345451.3_Frame_Shift_Del_p.F513fs|CPEB2_ENST00000382401.3_Frame_Shift_Del_p.F516fs|CPEB2_ENST00000382395.3_Frame_Shift_Del_p.F521fs	NM_001177382.1	NP_001170853.1	Q7Z5Q1	CPEB2_HUMAN	cytoplasmic polyadenylation element binding protein 2	543					regulation of translation	cytoplasm	nucleotide binding|RNA binding			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(1)|large_intestine(2)|lung(4)|prostate(1)|skin(3)	14						ATTTGCTCCCTTTTTTTGTGC	0.443													8	841	---	---	---	---					
SLC34A2	10568	broad.mit.edu	37	4	25678148	25678150	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr4:25678148_25678150delGCT	ENST00000382051.3	+	13	1900_1902	c.1850_1852delGCT	c.(1849-1854)cgc>c	p.RC617del	SLC34A2_ENST00000503434.1_In_Frame_Del_p.RC616del|SLC34A2_ENST00000504570.1_In_Frame_Del_p.RC616del	NM_001177998.1|NM_006424.2	NP_001171469.1|NP_006415.2	O95436	NPT2B_HUMAN	solute carrier family 34 (type II sodium/phosphate contransporter), member 2	617	Cys-rich.				cellular phosphate ion homeostasis	apical plasma membrane|brush border membrane|integral to plasma membrane	phosphate binding|sodium ion binding|sodium-dependent phosphate transmembrane transporter activity|sodium:phosphate symporter activity		SLC34A2/ROS1(14)	breast(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(9)|lung(18)|ovary(1)|prostate(1)|skin(4)	41		Breast(46;0.0503)				TTCCAGATGCgctgctgctgctg	0.640			T	ROS1	NSCLC								8	433	---	---	---	---					
N4BP2	55728	broad.mit.edu	37	4	40144449	40144449	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr4:40144449delA	ENST00000261435.6	+	15	5358	c.4942delA	c.(4942-4944)aafs	p.K1649fs		NM_018177.4	NP_060647.2	Q86UW6	N4BP2_HUMAN	NEDD4 binding protein 2	1649						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			breast(4)|endometrium(3)|kidney(12)|large_intestine(7)|liver(2)|lung(22)|ovary(1)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(1)	60						TCGGATAGGGAAAAAAAATGT	0.398													8	623	---	---	---	---					
LIMCH1	22998	broad.mit.edu	37	4	41648508	41648509	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr4:41648508_41648509delGA	ENST00000313860.7	+	12	1317_1318	c.1263_1264delGA	c.(1261-1266)cggafs	p.RR421fs	LIMCH1_ENST00000512820.1_Frame_Shift_Del_p.RR409fs|LIMCH1_ENST00000512632.1_Frame_Shift_Del_p.RR421fs|LIMCH1_ENST00000511496.1_Frame_Shift_Del_p.RR262fs|LIMCH1_ENST00000381753.4_Frame_Shift_Del_p.RR255fs|LIMCH1_ENST00000513024.1_Frame_Shift_Del_p.RR250fs|LIMCH1_ENST00000508501.1_Frame_Shift_Del_p.RR421fs|LIMCH1_ENST00000514096.1_Frame_Shift_Del_p.RR262fs|LIMCH1_ENST00000503057.1_Frame_Shift_Del_p.RR806fs|LIMCH1_ENST00000512946.1_Frame_Shift_Del_p.RR421fs|LIMCH1_ENST00000396595.3_Frame_Shift_Del_p.RR267fs|LIMCH1_ENST00000509277.1_Frame_Shift_Del_p.RR255fs	NM_014988.2	NP_055803.2	Q9UPQ0	LIMC1_HUMAN	LIM and calponin homology domains 1	421					actomyosin structure organization		actin binding|zinc ion binding	p.E810fs*3(1)|p.E425fs*3(1)		central_nervous_system(2)|endometrium(1)|large_intestine(9)|lung(17)|ovary(3)|pancreas(1)|prostate(3)|skin(5)	41						TTAGAGAGCGGAGAGAGAGAGA	0.465													13	772	---	---	---	---					
GABRG1	2565	broad.mit.edu	37	4	46060358	46060358	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr4:46060358delA	ENST00000295452.4	-	7	959	c.792delT	c.(790-792)ttfs	p.F264fs		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	264					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity	p.F264fs*3(1)		breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		TGCTCAGGTCAAAAAAAATTG	0.294													14	460	---	---	---	---					
RP11-453E17.1	0	broad.mit.edu	37	4	68632418	68632419	+	RNA	INS	-	-	AT	rs59536241	by1000genomes	TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr4:68632418_68632419insAT	ENST00000500538.2	+	0	1905				RP11-453E17.1_ENST00000502758.1_RNA																							cacacacacacaTATATATAct	0.431													20	30	---	---	---	---					
UTP3	57050	broad.mit.edu	37	4	71554620	71554622	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr4:71554620_71554622delGAG	ENST00000254803.2	+	1	425_427	c.226_228delGAG	c.(226-228)del	p.E81del		NM_020368.2	NP_065101.1	Q9NQZ2	SAS10_HUMAN	UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae)	81	Glu-rich.				brain development|chromatin modification|gene silencing	nucleolus				endometrium(2)|kidney(1)|large_intestine(3)|lung(7)|ovary(1)|prostate(4)	18			Lung(101;0.235)			ggaggatggcgaggaggaggagg	0.567													8	309	---	---	---	---					
NAP1L5	266812	broad.mit.edu	37	4	89618431	89618433	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr4:89618431_89618433delCCT	ENST00000323061.5	-	1	953_955	c.473_475delAGG	c.(472-477)gct>g	p.EA158del	HERC3_ENST00000543130.1_Intron|HERC3_ENST00000402738.1_Intron|HERC3_ENST00000264345.3_Intron	NM_153757.2	NP_715638.1	Q96NT1	NP1L5_HUMAN	nucleosome assembly protein 1-like 5	158	Glu-rich.				nucleosome assembly	nucleus	protein binding			endometrium(2)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	7				OV - Ovarian serous cystadenocarcinoma(123;0.000181)		TCTGCCGCAGcctcctcctcctc	0.626													12	896	---	---	---	---					
MAML3	55534	broad.mit.edu	37	4	140810639	140810641	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr4:140810639_140810641delGCT	ENST00000509479.2	-	2	2805_2807	c.1949_1951delAGC	c.(1948-1953)ccg>c	p.QP650del	MAML3_ENST00000327122.5_In_Frame_Del_p.QP494del|MAML3_ENST00000398940.1_In_Frame_Del_p.QP178del	NM_018717.4	NP_061187.2	Q96JK9	MAML3_HUMAN	mastermind-like 3 (Drosophila)	646	Gln-rich.				Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			breast(1)|endometrium(7)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|urinary_tract(2)	25	all_hematologic(180;0.162)					GGAGGTGGCGgctgctgctgctg	0.586													15	467	---	---	---	---					
SPOCK3	50859	broad.mit.edu	37	4	168155291	168155292	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr4:168155291_168155292delCA	ENST00000357154.3	-	2	170_171	c.33_34delTG	c.(31-36)tgcafs	p.CA11fs	SPOCK3_ENST00000512648.1_Frame_Shift_Del_p.CA11fs|SPOCK3_ENST00000512681.1_Frame_Shift_Del_p.CA11fs|SPOCK3_ENST00000541637.1_Frame_Shift_Del_p.CA11fs|SPOCK3_ENST00000506886.1_Frame_Shift_Del_p.CA11fs|SPOCK3_ENST00000421836.2_5'UTR|SPOCK3_ENST00000511531.1_Frame_Shift_Del_p.CA11fs|SPOCK3_ENST00000504953.1_Frame_Shift_Del_p.CA11fs|SPOCK3_ENST00000511269.1_Frame_Shift_Del_p.CA11fs|SPOCK3_ENST00000541354.1_5'UTR|SPOCK3_ENST00000502330.1_Frame_Shift_Del_p.CA11fs|SPOCK3_ENST00000510741.1_Frame_Shift_Del_p.CA11fs|SPOCK3_ENST00000357545.4_Frame_Shift_Del_p.CA11fs	NM_016950.2	NP_058646.2	Q9BQ16	TICN3_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3	11					signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	38	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		CAAGCGGCTGCACACACACACA	0.609													7	279	---	---	---	---					
CEP72	55722	broad.mit.edu	37	5	640649	640651	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr5:640649_640651delAGC	ENST00000264935.5	+	9	1559_1561	c.1469_1471delAGC	c.(1468-1473)gag>g	p.EQ490del	CEP72_ENST00000444221.1_3'UTR	NM_018140.3	NP_060610.2	Q9P209	CEP72_HUMAN	centrosomal protein 72kDa	490					G2/M transition of mitotic cell cycle|gamma-tubulin complex localization|spindle organization	centrosome|cytosol				autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(1)|liver(1)|lung(5)|ovary(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(2)	20			Epithelial(17;0.000339)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|Lung(60;0.0863)			CGCCTTGCTGAGCAGCAGCAGCA	0.621													7	389	---	---	---	---					
PDZD2	23037	broad.mit.edu	37	5	32090059	32090061	+	In_Frame_Del	DEL	TCC	TCC	-	rs61744453	by1000genomes	TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr5:32090059_32090061delTCC	ENST00000438447.1	+	20	6893_6895	c.6505_6507delTCC	c.(6505-6507)del	p.S2173del	PDZD2_ENST00000282493.3_In_Frame_Del_p.S2173del			O15018	PDZD2_HUMAN	PDZ domain containing 2	2173	Ser-rich.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				NS(2)|breast(4)|central_nervous_system(5)|cervix(2)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(31)|lung(58)|ovary(6)|prostate(2)|skin(8)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	148						AAAACTGGCGTCCTCCTCCTCCT	0.527													7	1075	---	---	---	---					
ZFR	51663	broad.mit.edu	37	5	32419951	32419953	+	In_Frame_Del	DEL	GGT	GGT	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr5:32419951_32419953delGGT	ENST00000265069.8	-	3	495_497	c.393_395delACC	c.(391-396)ccc>cc	p.PP131del		NM_016107.3	NP_057191.2	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	131	Ala-rich.				multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding			breast(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(14)|upper_aerodigestive_tract(2)	32				STAD - Stomach adenocarcinoma(35;0.19)		AGTAGCTGGGGGTGGTGGTGGTG	0.483													9	1307	---	---	---	---					
RP11-434D9.2	0	broad.mit.edu	37	5	67151825	67151826	+	RNA	INS	-	-	A			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr5:67151825_67151826insA	ENST00000514791.1	-	0	349																		p.0?(1)									AACCCCtttttaaaattcaaaa	0.396													7	290	---	---	---	---					
THBS4	7060	broad.mit.edu	37	5	79372774	79372776	+	In_Frame_Del	DEL	TGA	TGA	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr5:79372774_79372776delTGA	ENST00000350881.2	+	16	2179_2181	c.1989_1991delTGA	c.(1987-1992)tgt>tg	p.CD663del	THBS4_ENST00000511733.1_In_Frame_Del_p.CD572del|CTD-2201I18.1_ENST00000503007.1_RNA|CTD-2201I18.1_ENST00000514042.1_RNA	NM_003248.4	NP_003239.2	P35443	TSP4_HUMAN	thrombospondin 4	663					endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|stomach(3)	34		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		GTGACGAGTGTGATGATGATGAT	0.562													7	1677	---	---	---	---					
MSH3	4437	broad.mit.edu	37	5	79950742	79950750	+	In_Frame_Del	DEL	CCCCCAGCT	CCCCCAGCT	-	rs3045983		TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr5:79950742_79950750delCCCCCAGCT	ENST00000265081.6	+	1	276_284	c.196_204delCCCCCAGCT	c.(196-204)del	p.PPA66del	DHFR_ENST00000439211.2_5'UTR	NM_002439.4	NP_002430.3	P20585	MSH3_HUMAN	mutS homolog 3	66					maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(12)|ovary(1)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	29		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		gCCCCCAGCGCCCCCAGCTCCCGCCTTCC	0.732								Mismatch excision repair (MMR)					21	36	---	---	---	---					
ZNF608	57507	broad.mit.edu	37	5	124079813	124079815	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr5:124079813_124079815delCTC	ENST00000306315.5	-	1	1303_1305	c.868_870delGAG	c.(868-870)del	p.E290del	ZNF608_ENST00000504926.1_Intron	NM_020747.2	NP_065798.2	Q9ULD9	ZN608_HUMAN	zinc finger protein 608	290						intracellular	zinc ion binding			breast(4)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(12)|ovary(3)|skin(6)|urinary_tract(1)	46		all_cancers(142;0.186)|Prostate(80;0.081)	KIRC - Kidney renal clear cell carcinoma(527;0.159)|Kidney(363;0.221)	OV - Ovarian serous cystadenocarcinoma(64;0.00126)|Epithelial(69;0.00238)|all cancers(49;0.00783)		GCCTGTGGCTCTCCTCCTCCTCC	0.522													9	1652	---	---	---	---					
PCDHA9	0	broad.mit.edu	37	5	140230590	140230590	+	Frame_Shift_Del	DEL	T	T	-	rs17844337		TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr5:140230590delT	ENST00000378122.3	+	1	3234	c.2510delT	c.(2509-2511)atfs	p.I837fs	PCDHA1_ENST00000394633.3_Intron|PCDHA4_ENST00000530339.1_Intron|PCDHA5_ENST00000529859.1_Intron|PCDHA5_ENST00000529619.1_Intron|PCDHA6_ENST00000529310.1_Intron|PCDHA6_ENST00000527624.1_Intron|PCDHA1_ENST00000504120.2_Intron|PCDHA2_ENST00000526136.1_Intron|PCDHA7_ENST00000525929.1_Intron|PCDHA3_ENST00000522353.2_Intron|PCDHA4_ENST00000512229.2_Intron|PCDHA9_ENST00000532602.1_Intron|PCDHA8_ENST00000531613.1_Intron	NM_014005.3	NP_054724.1														breast(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|lung(18)|ovary(4)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	59			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATCCAGCAGATTTTTTTTCTG	0.279													11	1478	---	---	---	---					
FBXO38	81545	broad.mit.edu	37	5	147806939	147806940	+	Frame_Shift_Ins	INS	-	-	A	rs78530338		TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr5:147806939_147806940insA	ENST00000340253.5	+	15	2250_2251	c.2082_2083insA	c.(2080-2085)aaaaaafs	p.KK694fs	FBXO38_ENST00000394370.3_Frame_Shift_Ins_p.KK694fs|FBXO38_ENST00000296701.6_Intron|FBXO38_ENST00000513826.1_Intron			Q6PIJ6	FBX38_HUMAN	F-box protein 38	694						cytoplasm|nucleus			ATG4C/FBXO38(2)	NS(1)|breast(2)|endometrium(7)|kidney(5)|large_intestine(9)|lung(15)|ovary(5)|prostate(2)|skin(2)|stomach(2)|urinary_tract(1)	51			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCCTGAAAAGAAAAAAAACAA	0.500													7	289	---	---	---	---					
TIGD6	81789	broad.mit.edu	37	5	149375600	149375600	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr5:149375600delT	ENST00000296736.3	-	2	1086	c.312delA	c.(310-312)aafs	p.K104fs	TIGD6_ENST00000515406.2_Frame_Shift_Del_p.K104fs	NM_030953.3	NP_112215.1	Q17RP2	TIGD6_HUMAN	tigger transposable element derived 6	104	HTH CENPB-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|ovary(2)|prostate(1)|stomach(1)	10			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			AGTTTAGTGCTTTTTTCCGAA	0.423													10	1483	---	---	---	---					
TIMD4	91937	broad.mit.edu	37	5	156378745	156378747	+	In_Frame_Del	DEL	TTG	TTG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr5:156378745_156378747delTTG	ENST00000274532.2	-	3	511_513	c.455_457delCAA	c.(454-459)agc>a	p.TS152del	TIMD4_ENST00000407087.3_In_Frame_Del_p.TS152del	NM_138379.2	NP_612388.2	Q96H15	TIMD4_HUMAN	T-cell immunoglobulin and mucin domain containing 4	152	Thr-rich.					integral to membrane				NS(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(23)|ovary(2)|skin(2)	37	Renal(175;0.00488)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTGGTGGGGCTTGTTGTTGTTGT	0.537													7	1985	---	---	---	---					
DEK	7913	broad.mit.edu	37	6	18264079	18264081	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr6:18264079_18264081delTCC	ENST00000397239.3	-	2	585_587	c.138_140delGGA	c.(136-141)gaa>ga	p.EE46del	DEK_ENST00000244776.7_In_Frame_Del_p.EE46del	NM_003472.3	NP_003463.1	P35659	DEK_HUMAN	DEK oncogene	46	Asp/Glu-rich (highly acidic).				chromatin modification|regulation of transcription from RNA polymerase II promoter|signal transduction|transcription from RNA polymerase II promoter|viral genome replication	nucleus	DNA binding|histone binding			endometrium(1)|kidney(1)|large_intestine(2)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	7	Ovarian(93;0.00769)|Breast(50;0.0495)	all_hematologic(90;0.053)	OV - Ovarian serous cystadenocarcinoma(7;0.00291)|all cancers(50;0.031)|Epithelial(50;0.0332)			CCCACCTTTTtcctcctcctcct	0.532			T	NUP214	AML								10	448	---	---	---	---					
HIST1H1D	3007	broad.mit.edu	37	6	26235094	26235094	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr6:26235094delT	ENST00000244534.5	-	1	122	c.68delA	c.(67-69)agfs	p.K23fs		NM_005320.2	NP_005311.1	P16402	H13_HUMAN	histone cluster 1, H1d	23					nucleosome assembly	nucleosome|nucleus	DNA binding			breast(4)|endometrium(1)|haematopoietic_and_lymphoid_tissue(5)|large_intestine(4)|lung(7)|skin(1)|upper_aerodigestive_tract(1)	23		all_hematologic(11;0.0945)|Acute lymphoblastic leukemia(11;0.167)				CTTCTTCGCCTTTTTCTTCAC	0.507													7	649	---	---	---	---					
GABBR1	0	broad.mit.edu	37	6	29573436	29573438	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr6:29573436_29573438delCAG	ENST00000377034.4	-	20	2682_2684	c.2347_2349delCTG	c.(2347-2349)del	p.L783del	GABBR1_ENST00000355973.3_In_Frame_Del_p.L666del|GABBR1_ENST00000376977.3_3'UTR|GABBR1_ENST00000377016.4_In_Frame_Del_p.L721del|GABBR1_ENST00000377012.4_In_Frame_Del_p.L666del	NM_001470.2	NP_001461.1	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor, 1	783					gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity	p.L783M(1)		endometrium(3)|kidney(1)|large_intestine(13)|liver(1)|lung(16)|ovary(5)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47					Baclofen(DB00181)|Progabide(DB00837)	GGAAGATTCCCAGCAGCAGCAGC	0.512													9	601	---	---	---	---					
TNXB	7148	broad.mit.edu	37	6	32063513	32063514	+	Frame_Shift_Del	DEL	AC	AC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr6:32063513_32063514delAC	ENST00000375244.3	-	3	2317_2318	c.2116_2117delGT	c.(2116-2118)afs	p.V706fs	TNXB_ENST00000375247.2_Frame_Shift_Del_p.V706fs|TNXB_ENST00000479795.1_Frame_Shift_Del_p.V706fs			P22105	TENX_HUMAN	tenascin XB	706	EGF-like 18.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						GAAGCCCTCTACACACACACAC	0.668													8	291	---	---	---	---					
MDFI	4188	broad.mit.edu	37	6	41621169	41621171	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr6:41621169_41621171delCTG	ENST00000373050.4	+	4	601_603	c.414_416delCTG	c.(412-417)ctc>ct	p.LC138del				Q99750	MDFI_HUMAN	MyoD family inhibitor	199					cytoplasmic sequestering of transcription factor|dorsal/ventral axis specification|negative regulation of DNA binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of Wnt receptor signaling pathway	cytoplasm|nucleus				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|liver(2)|prostate(2)|skin(1)|urinary_tract(1)	8	Ovarian(28;0.0327)|Colorectal(47;0.121)		Colorectal(64;0.0123)|COAD - Colon adenocarcinoma(64;0.0264)|KIRC - Kidney renal clear cell carcinoma(1;0.138)			ACTCGTGCCTCTGCTGCTGCTGC	0.655													7	754	---	---	---	---					
AARS2	57505	broad.mit.edu	37	6	44269188	44269189	+	Frame_Shift_Ins	INS	-	-	T			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr6:44269188_44269189insT	ENST00000244571.4	-	20	2613_2614	c.2611_2612insA	c.(2611-2613)tcafs	p.S871fs	TMEM151B_ENST00000438774.2_Intron	NM_020745.3	NP_065796.1	Q5JTZ9	SYAM_HUMAN	alanyl-tRNA synthetase 2, mitochondrial	871					alanyl-tRNA aminoacylation	mitochondrion	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(1)|large_intestine(7)|lung(11)|ovary(3)|prostate(3)|skin(2)|stomach(1)	34	Hepatocellular(11;0.00908)|all_lung(25;0.0101)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		L-Alanine(DB00160)	CAGCTCCTGAGTTTTCTTTGCA	0.584													8	891	---	---	---	---					
TDRD6	221400	broad.mit.edu	37	6	46660414	46660415	+	Frame_Shift_Ins	INS	-	-	A	rs145334816		TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr6:46660414_46660415insA	ENST00000544460.1	+	1	4803_4804	c.4549_4550insA	c.(4549-4551)aaafs	p.K1517fs	TDRD6_ENST00000316081.6_Frame_Shift_Ins_p.K1517fs	NM_001168359.1	NP_001161831.1	O60522	TDRD6_HUMAN	tudor domain containing 6	1517					cell differentiation|multicellular organismal development|spermatogenesis	chromatoid body	nucleic acid binding			NS(1)|breast(9)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(25)|ovary(2)|pancreas(1)|prostate(1)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	80			Lung(136;0.192)			GTATAATCCAGAAAAAAAAATG	0.351													18	534	---	---	---	---					
GSTA1	2938	broad.mit.edu	37	6	52664097	52664100	+	Splice_Site	DEL	TGAA	TGAA	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr6:52664097_52664100delTGAA	ENST00000334575.5	-	2	126		c.e2-2			NM_145740.3	NP_665683.1	P08263	GSTA1_HUMAN	glutathione S-transferase alpha 1						glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			large_intestine(2)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)	12	Lung NSC(77;0.118)				Amsacrine(DB00276)|Busulfan(DB01008)|Glutathione(DB00143)	TCTCTAAGCCtgaatgaatgaatg	0.431													10	383	---	---	---	---					
C6orf165	154313	broad.mit.edu	37	6	88144700	88144700	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr6:88144700delA	ENST00000507897.1	+	11	1506	c.1423delA	c.(1423-1425)aafs	p.K476fs	C6ORF165_ENST00000369562.4_Frame_Shift_Del_p.K476fs			Q8IYR0	CF165_HUMAN	chromosome 6 open reading frame 165	476										NS(1)|central_nervous_system(1)|large_intestine(5)|lung(8)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		AGAAAAGGCCAAAAAAAATAC	0.269													8	390	---	---	---	---					
GABRR1	2569	broad.mit.edu	37	6	89891719	89891721	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr6:89891719_89891721delAAG	ENST00000435811.1	-	7	1255_1257	c.801_803delCTT	c.(799-804)ttg>tt	p.FL267del	GABRR1_ENST00000454853.2_In_Frame_Del_p.FL284del|GABRR1_ENST00000369451.3_In_Frame_Del_p.FL197del	NM_001256703.1	NP_001243632.1	P24046	GBRR1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, rho 1	284					gamma-aminobutyric acid signaling pathway|synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(7)|lung(16)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	35		all_cancers(76;9.49e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.46e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.00917)	Picrotoxin(DB00466)	AGTTTGGAGCAAGAAGAAGAAGA	0.522													10	713	---	---	---	---					
GABRR2	2570	broad.mit.edu	37	6	89975427	89975429	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr6:89975427_89975429delAAG	ENST00000402938.3	-	7	925_927	c.792_794delCTT	c.(790-795)ttg>tt	p.FL264del	GABRR2_ENST00000602399.1_In_Frame_Del_p.FL289del			P28476	GBRR2_HUMAN	gamma-aminobutyric acid (GABA) A receptor, rho 2	289					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(10)|prostate(2)|urinary_tract(1)	21		all_cancers(76;1.67e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.77e-07)|all_epithelial(107;2.51e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0158)		TGTTTGGAGCAAGAAGAAGAAGA	0.517													14	505	---	---	---	---					
UFL1	23376	broad.mit.edu	37	6	96999786	96999786	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr6:96999786delA	ENST00000369278.4	+	17	2038	c.1972delA	c.(1972-1974)aafs	p.K659fs		NM_015323.4	NP_056138.1	O94874	UFL1_HUMAN	UFM1-specific ligase 1	659					negative regulation of NF-kappaB transcription factor activity|negative regulation of protein ubiquitination|protein ufmylation	endoplasmic reticulum|nucleus	protein binding|UFM1 conjugating enzyme activity										AAGGGGAGACAAAAAAAGGGA	0.338													10	636	---	---	---	---					
SEC63	11231	broad.mit.edu	37	6	108214774	108214774	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr6:108214774delT	ENST00000369002.4	-	16	1765	c.1586delA	c.(1585-1587)agfs	p.K530fs		NM_007214.4	NP_009145.1	Q9UGP8	SEC63_HUMAN	SEC63 homolog (S. cerevisiae)	530	SEC63 1.				protein folding|protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|receptor activity|unfolded protein binding	p.K529fs*4(1)		endometrium(3)|kidney(4)|large_intestine(7)|lung(14)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36		all_cancers(87;5.35e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0294)		BRCA - Breast invasive adenocarcinoma(108;0.0079)|Epithelial(106;0.0356)|all cancers(137;0.0525)|OV - Ovarian serous cystadenocarcinoma(136;0.054)		TAAAGGTTTCTTTTTTTTTGA	0.368													8	885	---	---	---	---					
PPIL6	285755	broad.mit.edu	37	6	109757309	109757309	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr6:109757309delT	ENST00000521072.2	-	2	809	c.229delA	c.(229-231)ggfs	p.R77fs	PPIL6_ENST00000440797.2_Frame_Shift_Del_p.R77fs|PPIL6_ENST00000424445.2_Intron	NM_173672.4	NP_775943.1	Q8IXY8	PPIL6_HUMAN	peptidylprolyl isomerase (cyclophilin)-like 6	77					protein folding		peptidyl-prolyl cis-trans isomerase activity			large_intestine(3)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	6		all_cancers(87;1.1e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000144)|all_lung(197;0.0221)|Colorectal(196;0.0488)|Lung SC(18;0.0548)		Epithelial(106;0.00684)|BRCA - Breast invasive adenocarcinoma(108;0.00889)|all cancers(137;0.0106)|OV - Ovarian serous cystadenocarcinoma(136;0.0259)		TCCTTTACCCTTTTTTTCTCC	0.338													7	854	---	---	---	---					
KIAA0408	9729	broad.mit.edu	37	6	127767596	127767596	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr6:127767596delC	ENST00000483725.3	-	5	2204	c.1868delG	c.(1867-1869)gafs	p.G623fs	SOGA3_ENST00000556132.1_3'UTR|SOGA3_ENST00000481848.2_3'UTR	NM_014702.4	NP_055517.3	Q6ZU52	K0408_HUMAN	KIAA0408	623							protein binding			endometrium(3)|large_intestine(7)|lung(15)|ovary(1)|pancreas(1)|skin(1)	28				GBM - Glioblastoma multiforme(226;0.0217)|all cancers(137;0.13)		CACTTCCTGTCCCCCCCACAC	0.398													7	2198	---	---	---	---					
INTS1	26173	broad.mit.edu	37	7	1527075	1527075	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr7:1527075delG	ENST00000389470.4	-	21	2955	c.2956delC	c.(2956-2958)ggfs	p.R987fs	INTS1_ENST00000404767.3_Frame_Shift_Del_p.R844fs			Q8N201	INT1_HUMAN	integrator complex subunit 1	844					snRNA processing	integral to membrane|integrator complex|nuclear membrane				autonomic_ganglia(1)|cervix(1)|endometrium(14)|kidney(3)|large_intestine(7)|lung(24)|ovary(1)|prostate(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	62		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		GGAGGCCTCCGGGGGGGCCCC	0.667													7	155	---	---	---	---					
CARD11	84433	broad.mit.edu	37	7	2963941	2963943	+	In_Frame_Del	DEL	GGA	GGA	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr7:2963941_2963943delGGA	ENST00000396946.4	-	15	2267_2269	c.1864_1866delTCC	c.(1864-1866)del	p.S622del		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	622					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		CGGATTGGTGGGAGGAGGAGGAG	0.616			Mis		DLBCL								7	446	---	---	---	---					
ICA1	3382	broad.mit.edu	37	7	8198250	8198251	+	Frame_Shift_Ins	INS	-	-	T			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr7:8198250_8198251insT	ENST00000402384.3	-	7	877_878	c.611_612insA	c.(610-612)attfs	p.I204fs	ICA1_ENST00000265577.7_Frame_Shift_Ins_p.I203fs|ICA1_ENST00000406470.2_Frame_Shift_Ins_p.I204fs|ICA1_ENST00000401396.1_Frame_Shift_Ins_p.I192fs|ICA1_ENST00000422063.2_Frame_Shift_Ins_p.I204fs|ICA1_ENST00000407906.1_Frame_Shift_Ins_p.I204fs|ICA1_ENST00000396675.3_Frame_Shift_Ins_p.I204fs			Q05084	ICA69_HUMAN	islet cell autoantigen 1, 69kDa	204	AH.				neurotransmitter transport	cell junction|cytosol|Golgi membrane|nucleus|secretory granule membrane|synaptic vesicle membrane|transport vesicle membrane		p.N204fs*5(3)		breast(1)|central_nervous_system(2)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(8)|urinary_tract(1)	23		Ovarian(82;0.0612)		UCEC - Uterine corpus endometrioid carcinoma (126;0.246)		ATTTGTCAAAGTTTTTTTTTGC	0.376													10	442	---	---	---	---					
TWISTNB	221830	broad.mit.edu	37	7	19738111	19738113	+	In_Frame_Del	DEL	TTC	TTC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr7:19738111_19738113delTTC	ENST00000222567.5	-	4	913_915	c.843_845delGAA	c.(841-846)aaa>aa	p.KK281del		NM_001002926.1	NP_001002926.1	Q3B726	RPA43_HUMAN	TWIST neighbor	281	Lys-rich.					microtubule cytoskeleton|nucleolus	DNA-directed RNA polymerase activity			kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(2)	20						CTGGTGCTTTTTCTTCTTCTTCT	0.433													7	2799	---	---	---	---					
PURB	5814	broad.mit.edu	37	7	44924131	44924131	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr7:44924131delA	ENST00000395699.2	-	1	829	c.817delT	c.(817-819)gcfs	p.C273fs		NM_033224.3	NP_150093.1	Q96QR8	PURB_HUMAN	purine-rich element binding protein B	273					regulation of myeloid cell differentiation	DNA replication factor A complex	mRNA binding|single-stranded DNA binding|transcription factor binding			large_intestine(2)|lung(3)|prostate(1)|skin(1)	7						GCATACCGGCAAAAGGCGCCT	0.582													7	1093	---	---	---	---					
ZNF733P	0	broad.mit.edu	37	7	62752415	62752416	+	RNA	INS	-	-	C			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr7:62752415_62752416insC	ENST00000331425.6	-	0	1019_1020					NR_003952.1																						GCATAGGGTTTTCTCTAGTATG	0.421													7	132	---	---	---	---					
INTS4L2	0	broad.mit.edu	37	7	65150713	65150714	+	RNA	INS	-	-	A			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr7:65150713_65150714insA	ENST00000430126.2	+	0	694_695																											CATACCATGAGAAAATCTCTAA	0.436													14	428	---	---	---	---					
INTS4L2	0	broad.mit.edu	37	7	65150814	65150815	+	RNA	INS	-	-	C			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr7:65150814_65150815insC	ENST00000430126.2	+	0	757																											TCTTCATCCCTCACCCCCCCCC	0.460													7	154	---	---	---	---					
STX1A	6804	broad.mit.edu	37	7	73123425	73123427	+	In_Frame_Del	DEL	CAT	CAT	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr7:73123425_73123427delCAT	ENST00000222812.3	-	2	82_84	c.56_58delATG	c.(55-60)gtc>g	p.DV19del	STX1A_ENST00000395154.3_In_Frame_Del_p.DV19del|STX1A_ENST00000395155.3_In_Frame_Del_p.DV19del|STX1A_ENST00000395156.3_In_Frame_Del_p.DV19del	NM_004603.3	NP_004594.1	Q16623	STX1A_HUMAN	syntaxin 1A (brain)	19					energy reserve metabolic process|glutamate secretion|intracellular protein transport|regulation of insulin secretion	cell junction|extracellular region|integral to membrane|neuron projection|synaptic vesicle membrane|synaptosome	SNAP receptor activity			large_intestine(2)|lung(1)|skin(1)|upper_aerodigestive_tract(1)	5		Lung NSC(55;0.0908)|all_lung(88;0.198)				GTGACAGCGACATCATCATCATC	0.586													7	792	---	---	---	---					
PCLO	27445	broad.mit.edu	37	7	82595406	82595406	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr7:82595406delT	ENST00000423517.2	-	4	4035	c.3698delA	c.(3697-3699)agfs	p.K1233fs	PCLO_ENST00000333891.8_Frame_Shift_Del_p.K1233fs	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1172					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TAGGAGTGGCTTTTTTTCTTC	0.388													9	1912	---	---	---	---					
PEX1	5189	broad.mit.edu	37	7	92146721	92146721	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr7:92146721delT	ENST00000248633.4	-	5	1203	c.1108delA	c.(1108-1110)ttfs	p.I370fs	PEX1_ENST00000438045.1_Intron|PEX1_ENST00000541751.1_5'UTR|PEX1_ENST00000428214.1_Frame_Shift_Del_p.I370fs	NM_000466.2	NP_000457.1	O43933	PEX1_HUMAN	peroxisomal biogenesis factor 1	370					microtubule-based peroxisome localization|protein import into peroxisome matrix	cytosol|nucleus|peroxisomal membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding|protein complex binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(6)|lung(17)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	41	all_cancers(62;9.35e-11)|all_epithelial(64;4.59e-10)|Breast(17;0.00201)|all_lung(186;0.0438)|Lung NSC(181;0.0592)	Breast(660;0.000932)|all_neural(109;0.00391)|Myeloproliferative disorder(862;0.0122)|Ovarian(593;0.023)|Medulloblastoma(109;0.123)	GBM - Glioblastoma multiforme(5;4.06e-06)|STAD - Stomach adenocarcinoma(4;4.51e-05)|all cancers(6;5.32e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			TCTGACCTAATTTTTTTTTGA	0.353													25	889	---	---	---	---					
PTCD1	26024	broad.mit.edu	37	7	99032605	99032607	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr7:99032605_99032607delCTC	ENST00000292478.4	-	2	509_511	c.259_261delGAG	c.(259-261)del	p.E87del	ATP5J2-PTCD1_ENST00000413834.1_In_Frame_Del_p.E136del|PTCD1_ENST00000485746.1_5'UTR|PTCD1_ENST00000555673.1_In_Frame_Del_p.E136del	NM_015545.3	NP_056360.2			pentatricopeptide repeat domain 1									p.E87K(1)		endometrium(5)|large_intestine(3)|lung(16)|ovary(2)|skin(1)	27	all_cancers(62;2.54e-08)|all_epithelial(64;2.55e-09)|Lung NSC(181;0.0053)|all_lung(186;0.00895)|Esophageal squamous(72;0.0166)		STAD - Stomach adenocarcinoma(171;0.215)			TCCCAAAACTCTCCTCCTCCTCC	0.606													8	761	---	---	---	---					
MEPCE	56257	broad.mit.edu	37	7	100028823	100028825	+	In_Frame_Del	DEL	CCA	CCA	-	rs71555278		TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr7:100028823_100028825delCCA	ENST00000310512.2	+	1	1570_1572	c.1182_1184delCCA	c.(1180-1185)cgc>cg	p.RH394del	MEPCE_ENST00000414441.1_5'UTR	NM_019606.5	NP_062552.2	Q7L2J0	MEPCE_HUMAN	methylphosphate capping enzyme	394							methyltransferase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(2)|lung(9)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	24	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GGGGAGGCCGCCACCACCACCAC	0.581													7	503	---	---	---	---					
DPY19L2P2	0	broad.mit.edu	37	7	102883498	102883498	+	RNA	DEL	A	A	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr7:102883498delA	ENST00000312132.4	-	0	2616																											GTACCACTGTAAAAAAAAAAA	0.284													10	88	---	---	---	---					
C7orf55-LUC7L2	0	broad.mit.edu	37	7	139094365	139094366	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr7:139094365_139094366delAG	ENST00000354926.4	+	7	1098_1099	c.744_745delAG	c.(742-747)gaagfs	p.EE248fs	LUC7L2_ENST00000541515.3_Frame_Shift_Del_p.EE314fs|C7orf55-LUC7L2_ENST00000541170.3_Frame_Shift_Del_p.EE245fs|C7orf55-LUC7L2_ENST00000263545.6_Frame_Shift_Del_p.EE247fs	NM_016019.3	NP_057103.2																					AACGAAGAGAAGAGAGAGAGAG	0.391													10	182	---	---	---	---					
TRBV7-1	0	broad.mit.edu	37	7	142032162	142032163	+	RNA	DEL	GA	GA	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr7:142032162_142032163delGA	ENST00000547918.2	+	0	82																											atgtgtgtgtgAGAGAGAGAGA	0.505													7	101	---	---	---	---					
TRBV7-8	0	broad.mit.edu	37	7	142099832	142099833	+	RNA	DEL	CA	CA	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr7:142099832_142099833delCA	ENST00000390359.3	-	0	88																											accactctctcacacacacaca	0.455													10	491	---	---	---	---					
TRBV6-8	0	broad.mit.edu	37	7	142124496	142124497	+	RNA	INS	-	-	G	rs72463875		TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr7:142124496_142124497insG	ENST00000390376.2	-	0	49																											AATCCACGCAAGGGCCCTGCCC	0.614													7	620	---	---	---	---					
PRSS3P2	0	broad.mit.edu	37	7	142481743	142481745	+	RNA	DEL	CTA	CTA	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr7:142481743_142481745delCTA	ENST00000603901.1	+	0	454					NR_001296.3																						ACCCACATTTCTACTTTCTTTAT	0.517													21	342	---	---	---	---					
SFTPC	6440	broad.mit.edu	37	8	22021060	22021061	+	Frame_Shift_Del	DEL	GT	GT	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr8:22021060_22021061delGT	ENST00000522109.1	+	4	460_461	c.436_437delGT	c.(436-438)gfs	p.V146fs	SFTPC_ENST00000520605.1_Splice_Site|SFTPC_ENST00000437090.2_Splice_Site|SFTPC_ENST00000524255.1_Splice_Site|SFTPC_ENST00000318561.3_Splice_Site|SFTPC_ENST00000521315.1_Splice_Site			P11686	PSPC_HUMAN	surfactant protein C	146	BRICHOS.				respiratory gaseous exchange	extracellular space		p.M146fs*41(1)		autonomic_ganglia(1)|large_intestine(1)|lung(1)	3				Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		CAACTTCCAGGTGTGTGTGTGT	0.545													8	199	---	---	---	---					
ESCO2	157570	broad.mit.edu	37	8	27634576	27634577	+	Frame_Shift_Ins	INS	-	-	A	rs80359854		TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr8:27634576_27634577insA	ENST00000305188.8	+	3	989_990	c.751_752insA	c.(751-753)aaafs	p.K251fs	ESCO2_ENST00000523910.1_3'UTR|ESCO2_ENST00000397418.2_5'UTR	NM_001017420.2	NP_001017420.1	Q56NI9	ESCO2_HUMAN	establishment of sister chromatid cohesion N-acetyltransferase 2	251					cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding			autonomic_ganglia(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(5)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18		Ovarian(32;0.000953)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|KIRC - Kidney renal clear cell carcinoma(542;0.0955)|Kidney(114;0.115)|Colorectal(74;0.132)		GACTGTCAGTGAAAAAAAAACT	0.396									SC Phocomelia syndrome				8	431	---	---	---	---					
RAB11FIP1	80223	broad.mit.edu	37	8	37728932	37728933	+	Frame_Shift_Ins	INS	-	-	T			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr8:37728932_37728933insT	ENST00000330843.4	-	4	3399_3400	c.3387_3388insA	c.(3385-3390)aaccacfs	p.NH1129fs	RAB11FIP1_ENST00000522727.1_Intron|RAB11FIP1_ENST00000524118.1_Intron|RAB11FIP1_ENST00000523182.1_5'UTR|RAB11FIP1_ENST00000287263.4_Intron	NM_001002814.2	NP_001002814.2	Q6WKZ4	RFIP1_HUMAN	RAB11 family interacting protein 1 (class I)	1129					protein transport	centrosome|phagocytic vesicle membrane|recycling endosome	protein binding			NS(1)|breast(1)|central_nervous_system(4)|endometrium(3)|large_intestine(6)|lung(20)|ovary(3)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	49		Lung NSC(58;0.118)|all_lung(54;0.195)	LUSC - Lung squamous cell carcinoma(8;3.62e-11)			TCTGCTGTGGCTTTTTTTTGAG	0.545											OREG0018713	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	1393	---	---	---	---					
PKHD1L1	93035	broad.mit.edu	37	8	110455173	110455174	+	Splice_Site	INS	-	-	G			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr8:110455173_110455174insG	ENST00000378402.5	+	36	4497		c.e36-1			NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1						immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ATTTTATGGCAGGTTCATTTTC	0.322										HNSCC(38;0.096)			12	609	---	---	---	---					
PLIN2	123	broad.mit.edu	37	9	19119812	19119813	+	Frame_Shift_Ins	INS	-	-	T			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr9:19119812_19119813insT	ENST00000276914.2	-	6	791_792	c.612_613insA	c.(610-615)aattgafs	p.N*204fs	PLIN2_ENST00000411567.1_Frame_Shift_Ins_p.I161fs	NM_001122.3	NP_001113.2	Q99541	PLIN2_HUMAN	perilipin 2	204					cellular lipid metabolic process	endoplasmic reticulum|extracellular region|lipid particle				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(1)	19						AATCCTTCAACTTTTTTTGCTT	0.431													7	1000	---	---	---	---					
ASTN2	23245	broad.mit.edu	37	9	119976989	119976991	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr9:119976989_119976991delCAG	ENST00000313400.4	-	3	761_763	c.661_663delCTG	c.(661-663)del	p.L221del	ASTN2_ENST00000373996.3_In_Frame_Del_p.L221del|ASTN2_ENST00000361209.2_In_Frame_Del_p.L221del|ASTN2_ENST00000361477.3_5'UTR			O75129	ASTN2_HUMAN	astrotactin 2	221						integral to membrane				breast(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(21)|lung(45)|ovary(4)|pancreas(2)|prostate(2)|skin(9)|stomach(1)|urinary_tract(1)	102						CGGTGAACACCAGCAGCAGCAGC	0.601													10	399	---	---	---	---					
GAPVD1	26130	broad.mit.edu	37	9	128064260	128064260	+	Splice_Site	DEL	A	A	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr9:128064260delA	ENST00000470056.1	+	3	345		c.e3-1		GAPVD1_ENST00000265956.4_Splice_Site|GAPVD1_ENST00000394105.2_Splice_Site|GAPVD1_ENST00000394084.1_Splice_Site|GAPVD1_ENST00000394083.2_Splice_Site|GAPVD1_ENST00000297933.6_Splice_Site|GAPVD1_ENST00000495955.1_Splice_Site|GAPVD1_ENST00000312123.9_Splice_Site|GAPVD1_ENST00000394104.2_Splice_Site			Q14C86	GAPD1_HUMAN	GTPase activating protein and VPS9 domains 1						endocytosis|regulation of protein transport|regulation of small GTPase mediated signal transduction|signal transduction	cytosol|endosome|membrane	GTPase activating protein binding|GTPase activator activity|guanyl-nucleotide exchange factor activity			central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(10)|lung(11)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						TTTTTTTTTTAGTGCTGAAGC	0.328													7	345	---	---	---	---					
GAPVD1	26130	broad.mit.edu	37	9	128122874	128122874	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr9:128122874delC	ENST00000470056.1	+	24	4191	c.4031delC	c.(4030-4032)acfs	p.T1344fs	GAPVD1_ENST00000265956.4_Frame_Shift_Del_p.T1363fs|GAPVD1_ENST00000394105.2_Frame_Shift_Del_p.T1398fs|GAPVD1_ENST00000394083.2_Frame_Shift_Del_p.T1323fs|GAPVD1_ENST00000297933.6_Frame_Shift_Del_p.T1371fs|GAPVD1_ENST00000495955.1_Frame_Shift_Del_p.T1389fs|GAPVD1_ENST00000312123.9_Frame_Shift_Del_p.T1350fs|GAPVD1_ENST00000394104.2_Frame_Shift_Del_p.T1389fs			Q14C86	GAPD1_HUMAN	GTPase activating protein and VPS9 domains 1	1389	VPS9.				endocytosis|regulation of protein transport|regulation of small GTPase mediated signal transduction|signal transduction	cytosol|endosome|membrane	GTPase activating protein binding|GTPase activator activity|guanyl-nucleotide exchange factor activity			central_nervous_system(2)|endometrium(7)|kidney(4)|large_intestine(10)|lung(11)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	44						GCTTATAAAACCCCCCGGGAC	0.468													7	533	---	---	---	---					
PRDM12	59335	broad.mit.edu	37	9	133543701	133543702	+	Splice_Site	DEL	GT	GT	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr9:133543701_133543702delGT	ENST00000253008.2	+	3	630		c.e3+1			NM_021619.2	NP_067632.2	Q9H4Q4	PRD12_HUMAN	PR domain containing 12						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			kidney(2)|large_intestine(3)|lung(4)|ovary(1)|upper_aerodigestive_tract(1)	11		all_hematologic(13;0.0433)|Acute lymphoblastic leukemia(5;0.0534)		OV - Ovarian serous cystadenocarcinoma(145;0.000344)		GGCCATTGAGGTGTGTGTGTGT	0.594													22	439	---	---	---	---					
CEL	1056	broad.mit.edu	37	9	135941982	135941982	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr9:135941982delG	ENST00000372080.4	+	5	629	c.613delG	c.(613-615)ggfs	p.G206fs	CEL_ENST00000351304.7_Frame_Shift_Del_p.G203fs	NM_001807.3	NP_001798.2	P19835	CEL_HUMAN	carboxyl ester lipase	203					cholesterol catabolic process|fatty acid catabolic process|intestinal cholesterol absorption|intestinal lipid catabolic process|pancreatic juice secretion|protein esterification	cytosol|extracellular space	acylglycerol lipase activity|carboxylesterase activity|heparin binding|sterol esterase activity|triglyceride lipase activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|pancreas(2)|skin(1)	20				OV - Ovarian serous cystadenocarcinoma(145;1.03e-40)|Epithelial(140;3.58e-37)|GBM - Glioblastoma multiforme(294;0.00164)|READ - Rectum adenocarcinoma(205;0.196)		CGCGGCCTTCGGGGGGGACCC	0.642													9	1785	---	---	---	---					
KIAA1217	56243	broad.mit.edu	37	10	24822125	24822127	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr10:24822125_24822127delGAA	ENST00000376451.2	+	11	2682_2684	c.2422_2424delGAA	c.(2422-2424)del	p.E812del	KIAA1217_ENST00000376452.3_In_Frame_Del_p.E1093del|KIAA1217_ENST00000307544.6_In_Frame_Del_p.E812del|KIAA1217_ENST00000376454.3_In_Frame_Del_p.E1129del|KIAA1217_ENST00000396445.1_In_Frame_Del_p.E812del|KIAA1217_ENST00000396446.1_In_Frame_Del_p.E812del|KIAA1217_ENST00000458595.1_In_Frame_Del_p.E1094del|KIAA1217_ENST00000376462.1_In_Frame_Del_p.E1049del			Q5T5P2	SKT_HUMAN	KIAA1217	1129					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						GGATGAGGAGGAAGAAGAAGAAG	0.552													10	445	---	---	---	---					
KIAA1462	57608	broad.mit.edu	37	10	30316501	30316503	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr10:30316501_30316503delCTG	ENST00000375377.1	-	3	2675_2677	c.2574_2576delCAG	c.(2572-2577)agt>ag	p.SS858del		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	858	Ser-rich.									breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						ACTCTCCTCActgctgctgctgc	0.571													26	622	---	---	---	---					
SYT15	83849	broad.mit.edu	37	10	46969401	46969403	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr10:46969401_46969403delCAG	ENST00000374325.3	-	2	210_212	c.58_60delCTG	c.(58-60)del	p.L21del	SYT15_ENST00000503753.1_In_Frame_Del_p.L21del|SYT15_ENST00000374321.4_In_Frame_Del_p.L21del|SYT15_ENST00000374323.3_Intron	NM_181519.2	NP_852660.1	Q9BQS2	SYT15_HUMAN	synaptotagmin XV	21						integral to membrane|plasma membrane				cervix(1)|endometrium(5)|kidney(2)|lung(5)	13						CCCCGATCAACAGCAGCAGCAGC	0.631													8	373	---	---	---	---					
RTKN2	219790	broad.mit.edu	37	10	63958148	63958149	+	Frame_Shift_Ins	INS	-	-	T			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr10:63958148_63958149insT	ENST00000373789.3	-	12	1444_1445	c.1348_1349insA	c.(1348-1350)tgafs	p.*450fs	RTKN2_ENST00000395265.1_Frame_Shift_Ins_p.*471fs|RTKN2_ENST00000315289.2_Frame_Shift_Ins_p.*252fs	NM_145307.2	NP_660350.2	Q8IZC4	RTKN2_HUMAN	rhotekin 2	450					signal transduction	intracellular		p.I450fs*67(1)		endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(3)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Prostate(12;0.0297)|all_hematologic(501;0.215)					TGTCTCTTCAATTTTTTTTTGT	0.337													7	524	---	---	---	---					
EGR2	1959	broad.mit.edu	37	10	64573487	64573489	+	In_Frame_Del	DEL	GCT	GCT	-	rs112474655		TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr10:64573487_64573489delGCT	ENST00000242480.3	-	2	1234_1236	c.909_911delAGC	c.(907-912)gcc>gc	p.AA307del	EGR2_ENST00000411732.1_In_Frame_Del_p.AA257del|EGR2_ENST00000439032.1_In_Frame_Del_p.AA307del	NM_000399.3|NM_001136177.1	NP_000390.2|NP_001129649.1	P11161	EGR2_HUMAN	early growth response 2	307	Poly-Ala.				fat cell differentiation|protein export from nucleus|transcription from RNA polymerase II promoter	cytoplasm|nucleus	chromatin binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(10)|lung(13)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)	36	Prostate(12;0.0297)|all_hematologic(501;0.228)					GGCGGCGGCGGCTGCTGCTGCTG	0.695													7	266	---	---	---	---					
NLRP6	171389	broad.mit.edu	37	11	281553	281555	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr11:281553_281555delGAG	ENST00000534750.1	+	4	2024_2026	c.1819_1821delGAG	c.(1819-1821)del	p.E611del	NLRP6_ENST00000312165.5_In_Frame_Del_p.E611del	NM_001276700.1	NP_001263629.1	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	611	Poly-Glu.					cytoplasm	ATP binding			breast(1)|skin(1)|upper_aerodigestive_tract(2)	4		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		CGAAGAGCCAGAGGAGGAGGAGG	0.670													11	865	---	---	---	---					
KRTAP5-5	439915	broad.mit.edu	37	11	1651158	1651169	+	In_Frame_Del	DEL	GGCTGTGGCTCT	GGCTGTGGCTCT	-	rs71454095	by1000genomes	TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr11:1651158_1651169delGGCTGTGGCTCT	ENST00000399676.2	+	1	126_137	c.88_99delGGCTGTGGCTCT	c.(88-99)del	p.GCGS30del		NM_001001480.2	NP_001001480.2	Q701N2	KRA55_HUMAN	keratin associated protein 5-5	30						keratin filament				endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|lung(17)|ovary(2)|prostate(5)|urinary_tract(1)	33		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000614)|Lung(200;0.0681)|LUSC - Lung squamous cell carcinoma(625;0.082)		cggctgtggaggctgtggctctggctgtgggg	0.708													7	801	---	---	---	---					
NAP1L4	4676	broad.mit.edu	37	11	2991166	2991167	+	Splice_Site	INS	-	-	A			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr11:2991166_2991167insA	ENST00000380542.4	-	7	543		c.e7-2		NAP1L4_ENST00000526115.1_Splice_Site	NM_005969.3	NP_005960.1	Q99733	NP1L4_HUMAN	nucleosome assembly protein 1-like 4						nucleosome assembly	chromatin assembly complex|cytoplasm	unfolded protein binding			endometrium(2)|kidney(3)|large_intestine(1)|lung(6)|ovary(1)	13		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00301)|LUSC - Lung squamous cell carcinoma(625;0.211)		CATGTCTCCCTAAAAAAAAGAT	0.416													7	330	---	---	---	---					
APBB1	322	broad.mit.edu	37	11	6432090	6432092	+	In_Frame_Del	DEL	TCC	TCC	-	rs145320037		TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr11:6432090_6432092delTCC	ENST00000389906.2	-	2	585_587	c.486_488delGGA	c.(484-489)gat>ga	p.ED162del	APBB1_ENST00000533407.1_Intron|APBB1_ENST00000311051.3_In_Frame_Del_p.ED162del|APBB1_ENST00000299402.6_In_Frame_Del_p.ED162del	NM_001257325.1	NP_001244254.1	O00213	APBB1_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	162	Glu-rich.				apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding	p.E162D(1)		breast(4)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|prostate(2)|skin(1)|urinary_tract(1)	24		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		atcatcatcatcctcctcctcct	0.635													7	357	---	---	---	---					
OR10A5	144124	broad.mit.edu	37	11	6867223	6867225	+	In_Frame_Del	DEL	TTC	TTC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr11:6867223_6867225delTTC	ENST00000299454.4	+	1	341_343	c.310_312delTTC	c.(310-312)del	p.F108del	OR10A5_ENST00000379831.2_In_Frame_Del_p.F112del			Q9H207	O10A5_HUMAN	olfactory receptor, family 10, subfamily A, member 5	108					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(1)|skin(2)|urinary_tract(2)	21		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.68e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TCAGATGTATTTCTTCTTCTTCT	0.517													7	980	---	---	---	---					
OR10A2	341276	broad.mit.edu	37	11	6891253	6891255	+	In_Frame_Del	DEL	TTC	TTC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr11:6891253_6891255delTTC	ENST00000307322.4	+	1	330_332	c.268_270delTTC	c.(268-270)del	p.F94del		NM_001004460.1	NP_001004460.1	Q9H208	O10A2_HUMAN	olfactory receptor, family 10, subfamily A, member 2	94					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(12)|urinary_tract(1)	24		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.89e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		TCAGATGTATTTCTTCTTCTTCT	0.517													9	1014	---	---	---	---					
SPON1	10418	broad.mit.edu	37	11	14276276	14276277	+	RNA	DEL	GT	GT	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr11:14276276_14276277delGT	ENST00000310358.7	+	0	1627							Q9HCB6	SPON1_HUMAN	spondin 1, extracellular matrix protein						cell adhesion	extracellular space|proteinaceous extracellular matrix	protein binding			NS(1)|endometrium(1)|large_intestine(5)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)	21				Epithelial(150;0.00898)		GACCTATGAGGTGTGTGTGTGT	0.594													9	325	---	---	---	---					
COPB1	1315	broad.mit.edu	37	11	14501262	14501263	+	Splice_Site	INS	-	-	A			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr11:14501262_14501263insA	ENST00000249923.3	-	11	1513		c.e11-2		COPB1_ENST00000439561.2_Splice_Site	NM_016451.4	NP_057535.1	P53618	COPB_HUMAN	coatomer protein complex, subunit beta 1						COPI coating of Golgi vesicle|interspecies interaction between organisms|intra-Golgi vesicle-mediated transport|intracellular protein transport|retrograde vesicle-mediated transport, Golgi to ER	COPI vesicle coat|cytosol|ER-Golgi intermediate compartment|plasma membrane	protein binding|structural molecule activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(12)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	36						TTCCATTAACTAAAAGAAAAAA	0.307													9	238	---	---	---	---					
PSMA1	5682	broad.mit.edu	37	11	14529252	14529254	+	In_Frame_Del	DEL	CAT	CAT	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr11:14529252_14529254delCAT	ENST00000530457.1	-	9	1138_1140	c.608_610delATG	c.(607-612)gtg>g	p.DV203del	PSMA1_ENST00000396393.1_In_Frame_Del_p.DV228del|PSMA1_ENST00000524606.1_5'UTR|PSMA1_ENST00000555531.1_3'UTR|PSMA1_ENST00000396394.2_In_Frame_Del_p.DV228del|PSMA1_ENST00000418988.2_In_Frame_Del_p.DV234del|PSMA1_ENST00000419365.2_3'UTR			P25786	PSA1_HUMAN	proteasome (prosome, macropain) subunit, alpha type, 1	228					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|polysome|proteasome core complex, alpha-subunit complex	protein binding|RNA binding|threonine-type endopeptidase activity			large_intestine(1)|skin(1)|upper_aerodigestive_tract(1)	3						AATGGAGACACATCATCATCATC	0.360													7	617	---	---	---	---					
TRIM51HP	0	broad.mit.edu	37	11	55065032	55065032	+	RNA	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr11:55065032delT	ENST00000526016.1	-	0	393					NR_038174.2																						AAAGACTGCATTTTTTTTTAG	0.398													7	401	---	---	---	---					
OR5A1	219982	broad.mit.edu	37	11	59210950	59210951	+	Frame_Shift_Ins	INS	-	-	T			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr11:59210950_59210951insT	ENST00000302030.2	+	1	334_335	c.309_310insT	c.(307-312)cattttfs	p.HF103fs		NM_001004728.1	NP_001004728.1	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A, member 1	103					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|endometrium(3)|large_intestine(2)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	28						GTGCTGCTCAGTTTTTTTTCTT	0.510													7	1122	---	---	---	---					
FADS2	9415	broad.mit.edu	37	11	61607885	61607887	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr11:61607885_61607887delTCC	ENST00000278840.4	+	3	1028_1030	c.398_400delTCC	c.(397-402)ttc>t	p.FL133del	FADS2_ENST00000257261.6_In_Frame_Del_p.FL111del|FADS2_ENST00000522056.1_In_Frame_Del_p.FL102del|FADS2_ENST00000521849.1_In_Frame_Del_p.FL133del	NM_004265.2	NP_004256.1	O95864	FADS2_HUMAN	fatty acid desaturase 2	133					electron transport chain|transport|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	heme binding			breast(2)|kidney(2)|large_intestine(4)|liver(1)|lung(2)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	20					Alpha-Linolenic Acid(DB00132)	CACGTGTTCTTCCTCCTCCTCCT	0.537													8	1207	---	---	---	---					
LRFN4	78999	broad.mit.edu	37	11	66625231	66625233	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr11:66625231_66625233delCTG	ENST00000309602.4	+	1	259_261	c.16_18delCTG	c.(16-18)del	p.L10del	PC_ENST00000393960.1_Intron|LRFN4_ENST00000531590.1_3'UTR|LRFN4_ENST00000393952.3_In_Frame_Del_p.L10del|PC_ENST00000393955.2_Intron|PC_ENST00000393958.2_Intron	NM_024036.4	NP_076941.2	Q6PJG9	LRFN4_HUMAN	leucine rich repeat and fibronectin type III domain containing 4	10						integral to membrane				breast(1)|lung(1)|prostate(1)	3						CCCGCCGCTCCTGCTGCTGCTGC	0.719													7	219	---	---	---	---					
UVRAG	7405	broad.mit.edu	37	11	75694430	75694431	+	Splice_Site	INS	-	-	A			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr11:75694430_75694431insA	ENST00000356136.3	+	8	940_941		c.e8-1		UVRAG_ENST00000531818.1_Splice_Site|UVRAG_ENST00000532130.1_Splice_Site|UVRAG_ENST00000533454.1_Splice_Site|UVRAG_ENST00000528420.1_Splice_Site	NM_003369.3	NP_003360.2	Q9P2Y5	UVRAG_HUMAN	UV radiation resistance associated						DNA repair|positive regulation of autophagy	early endosome|late endosome|lysosome	protein binding			central_nervous_system(1)|cervix(3)|endometrium(3)|kidney(1)|large_intestine(2)|lung(15)|skin(5)|urinary_tract(2)	32						TATTTATTTAGAAAAAAAAAAG	0.302													13	227	---	---	---	---					
MMP20	9313	broad.mit.edu	37	11	102487558	102487558	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr11:102487558delT	ENST00000260228.2	-	2	371	c.359delA	c.(358-360)atfs	p.N120fs	RP11-817J15.2_ENST00000542119.1_RNA	NM_004771.3	NP_004762.2	O60882	MMP20_HUMAN	matrix metallopeptidase 20	120					proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			endometrium(1)|kidney(4)|large_intestine(3)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	27	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		TGTCAAAGTATTTTTTTTCCA	0.398													7	396	---	---	---	---					
PIH1D2	120379	broad.mit.edu	37	11	111941931	111941932	+	Frame_Shift_Ins	INS	-	-	T			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr11:111941931_111941932insT	ENST00000530641.1	-	4	702_703	c.377_378insA	c.(376-378)acafs	p.T126fs	PIH1D2_ENST00000280350.4_Frame_Shift_Ins_p.T126fs|PIH1D2_ENST00000532211.1_Frame_Shift_Ins_p.T126fs|PIH1D2_ENST00000528775.1_Frame_Shift_Ins_p.T126fs|PIH1D2_ENST00000521853.2_5'UTR|PIH1D2_ENST00000431456.1_Frame_Shift_Ins_p.T126fs			Q8WWB5	PIHD2_HUMAN	PIH1 domain containing 2	126										endometrium(2)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	11		all_cancers(61;1.09e-14)|all_epithelial(67;7.64e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;3.19e-07)|BRCA - Breast invasive adenocarcinoma(274;6.17e-07)|all cancers(92;6.18e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.0508)		GAATTAACTGATTTTTTTTCAC	0.376													8	1062	---	---	---	---					
PVRL1	5818	broad.mit.edu	37	11	119535678	119535680	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr11:119535678_119535680delCCT	ENST00000264025.3	-	6	1861_1863	c.1331_1333delAGG	c.(1330-1335)ggc>g	p.EG444del	PVRL1_ENST00000341398.2_Intron	NM_002855.4	NP_002846.3	Q15223	PVRL1_HUMAN	poliovirus receptor-related 1 (herpesvirus entry mediator C)	444	Poly-Glu.				adherens junction organization|cell junction assembly|entry of virus into host cell|heterophilic cell-cell adhesion|homophilic cell adhesion|immune response	cell-cell adherens junction|extracellular region|integral to membrane	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity	p.E444fs*>73(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|liver(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		Breast(348;0.037)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.29e-05)		CCTCCACCGCcctcctcctcctc	0.660													11	237	---	---	---	---					
NFRKB	4798	broad.mit.edu	37	11	129752496	129752496	+	Frame_Shift_Del	DEL	T	T	-	rs149369172		TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr11:129752496delT	ENST00000446488.3	-	9	1035	c.932delA	c.(931-933)agfs	p.K311fs	NFRKB_ENST00000304521.5_Frame_Shift_Del_p.K311fs|NFRKB_ENST00000524794.1_Frame_Shift_Del_p.K336fs|NFRKB_ENST00000524746.1_Frame_Shift_Del_p.K311fs	NM_001143835.1	NP_001137307.1	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	311	Lys-rich.				DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(13)|ovary(4)|skin(3)|urinary_tract(1)	32	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		TTCCTTAACCTTTTTTTTAAG	0.438													8	640	---	---	---	---					
NCAPD3	23310	broad.mit.edu	37	11	134062759	134062759	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr11:134062759delC	ENST00000534548.2	-	16	1934	c.1870delG	c.(1870-1872)tgfs	p.V625fs		NM_015261.2	NP_056076.1	P42695	CNDD3_HUMAN	non-SMC condensin II complex, subunit D3	625					cell division|mitotic chromosome condensation	nuclear centromeric heterochromatin|nuclear condensin complex	methylated histone residue binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(10)|kidney(5)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_hematologic(175;0.127)	all_cancers(12;1.68e-21)|all_epithelial(12;5.86e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000182)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;8.74e-10)|BRCA - Breast invasive adenocarcinoma(10;1e-08)|all cancers(11;1.46e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00345)|Lung(977;0.227)		ACCGGGACCACCCCCCGCAAC	0.542													7	807	---	---	---	---					
CHD4	1108	broad.mit.edu	37	12	6711546	6711546	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr12:6711546delT	ENST00000309577.6	-	3	381	c.218delA	c.(217-219)agfs	p.K73fs	CHD4_ENST00000544040.1_Frame_Shift_Del_p.K73fs|CHD4_ENST00000357008.2_Frame_Shift_Del_p.K73fs|CHD4_ENST00000544484.1_Frame_Shift_Del_p.K70fs			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	73					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						ACTCACCTCCTTTTTTTGGCG	0.468													8	1966	---	---	---	---					
SLCO1B3	28234	broad.mit.edu	37	12	21028267	21028267	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr12:21028267delT	ENST00000381545.3	+	9	1045	c.826delT	c.(826-828)ttfs	p.F278fs	SLCO1B3_ENST00000261196.2_Frame_Shift_Del_p.F278fs|LST3_ENST00000540229.1_Frame_Shift_Del_p.F278fs|LST3_ENST00000381541.3_Intron|SLCO1B3_ENST00000553473.1_Frame_Shift_Del_p.F278fs|SLCO1B7_ENST00000554957.1_Intron	NM_019844.3	NP_062818.1	Q9NPD5	SO1B3_HUMAN	solute carrier organic anion transporter family, member 1B3	278					bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|cytoplasm|integral to plasma membrane	bile acid transmembrane transporter activity|organic anion transmembrane transporter activity			breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(23)|ovary(2)|prostate(2)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(2)	63	Esophageal squamous(101;0.149)					TTCCATACCATTTTTTTTCTT	0.363													11	775	---	---	---	---					
FAR2	55711	broad.mit.edu	37	12	29450110	29450110	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr12:29450110delA	ENST00000182377.4	+	4	790	c.522delA	c.(520-522)ccfs	p.P174fs	FAR2_ENST00000547116.1_Frame_Shift_Del_p.P77fs|FAR2_ENST00000536681.2_Frame_Shift_Del_p.P174fs|RP11-996F15.2_ENST00000553105.1_RNA	NM_018099.3	NP_060569.3	Q96K12	FACR2_HUMAN	fatty acyl CoA reductase 2	174					ether lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor			central_nervous_system(1)|endometrium(3)|large_intestine(6)|liver(2)|lung(15)|prostate(1)|stomach(1)	29						CTGTGGAGCCAAAAAAAATCA	0.388													15	977	---	---	---	---					
SCAF11	9169	broad.mit.edu	37	12	46320707	46320708	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr12:46320707_46320708delTC	ENST00000465950.1	-	1	3040_3041	c.1831_1832delGA	c.(1831-1833)afs	p.E611fs	SCAF11_ENST00000419565.2_Frame_Shift_Del_p.E926fs|SCAF11_ENST00000549162.1_Frame_Shift_Del_p.E734fs|SCAF11_ENST00000369367.3_Frame_Shift_Del_p.E926fs			Q99590	SCAFB_HUMAN	SR-related CTD-associated factor 11	926					spliceosome assembly	nucleus	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(17)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	69						GGTTCTCCTTTCTCTCTCTCTC	0.446													21	1158	---	---	---	---					
KRT73	319101	broad.mit.edu	37	12	53001991	53001991	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr12:53001991delT	ENST00000305748.3	-	9	1646	c.1612delA	c.(1612-1614)ccfs	p.T538fs	RP11-641A6.2_ENST00000551089.1_RNA	NM_175068.2	NP_778238.1	Q86Y46	K2C73_HUMAN	keratin 73	538	Tail.					keratin filament	structural molecule activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44				BRCA - Breast invasive adenocarcinoma(357;0.189)		TATCTCATGGTTTTTTTGGTG	0.532													8	1425	---	---	---	---					
SLC39A5	283375	broad.mit.edu	37	12	56628997	56628999	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr12:56628997_56628999delCTG	ENST00000266980.4	+	5	984_986	c.691_693delCTG	c.(691-693)del	p.L234del	SLC39A5_ENST00000454355.2_In_Frame_Del_p.L234del	NM_001135195.1	NP_001128667.1	Q6ZMH5	S39A5_HUMAN	solute carrier family 39 (zinc transporter), member 5	234					zinc ion transport	basolateral plasma membrane|integral to membrane	metal ion transmembrane transporter activity			NS(1)|cervix(6)|endometrium(1)|large_intestine(5)|lung(6)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TCCCCTATCCCTGCTGCTGCTGC	0.635													7	1542	---	---	---	---					
TMEM19	55266	broad.mit.edu	37	12	72094757	72094757	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr12:72094757delT	ENST00000266673.5	+	6	1587	c.993delT	c.(991-993)ggfs	p.G331fs		NM_018279.3	NP_060749.2	Q96HH6	TMM19_HUMAN	transmembrane protein 19	331						integral to membrane				large_intestine(1)|lung(8)	9		Breast(359;0.0889)		GBM - Glioblastoma multiforme(134;0.044)		CTGCTTGGGGTTTTTGGCCCA	0.433													12	1249	---	---	---	---					
UTP20	27340	broad.mit.edu	37	12	101680157	101680157	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr12:101680157delT	ENST00000261637.4	+	5	559	c.385delT	c.(385-387)ttfs	p.F130fs		NM_014503.2	NP_055318.2	O75691	UTP20_HUMAN	UTP20, small subunit (SSU) processome component, homolog (yeast)	130					endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|negative regulation of cell proliferation	90S preribosome|cytoplasm|nucleolus|nucleoplasm|preribosome, small subunit precursor|small-subunit processome	protein binding			NS(3)|biliary_tract(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(26)|lung(30)|ovary(2)|prostate(3)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	88						CTTTCCAGAGTTTTTTTTGAC	0.398													9	1581	---	---	---	---					
GCN1L1	10985	broad.mit.edu	37	12	120595737	120595739	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr12:120595737_120595739delCTC	ENST00000300648.6	-	26	3013_3015	c.3001_3003delGAG	c.(3001-3003)del	p.E1001del		NM_006836.1	NP_006827.1	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis 1-like 1 (yeast)	1001					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			NS(2)|breast(2)|cervix(2)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(13)|liver(1)|lung(36)|ovary(4)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	94	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGGCCATCCACTCCTCCTCCTCC	0.631													7	485	---	---	---	---					
MLEC	9761	broad.mit.edu	37	12	121134166	121134168	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr12:121134166_121134168delGAA	ENST00000228506.3	+	5	1125_1127	c.697_699delGAA	c.(697-699)del	p.E238del	MLEC_ENST00000412616.2_In_Frame_Del_p.RK154del	NM_014730.2	NP_055545.1	Q14165	MLEC_HUMAN	malectin	238	Poly-Glu.				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	carbohydrate binding	p.E233E(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)	16						gaaagaagaggaagaagaagaag	0.458													26	1246	---	---	---	---					
SNRNP35	11066	broad.mit.edu	37	12	123950763	123950764	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr12:123950763_123950764delGA	ENST00000526639.2	+	2	1255_1256	c.676_677delGA	c.(676-678)gfs	p.E226fs	SNRNP35_ENST00000412157.2_Frame_Shift_Del_p.E231fs|SNRNP35_ENST00000527158.2_Intron|SNRNP35_ENST00000350887.5_Frame_Shift_Del_p.E226fs	NM_022717.2	NP_073208.1	Q16560	U1SBP_HUMAN	small nuclear ribonucleoprotein 35kDa (U11/U12)	226	Arg-rich.				mRNA processing	U12-type spliceosomal complex	nucleotide binding|RNA binding	p.E226*(1)		NS(1)|large_intestine(1)|lung(4)|prostate(1)|skin(1)	8						CAATGACTGGGAGAGAGAGAGG	0.554													7	352	---	---	---	---					
DDX55	57696	broad.mit.edu	37	12	124103201	124103202	+	Translation_Start_Site	DEL	TG	TG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr12:124103201_124103202delTG	ENST00000421670.3	+	0	639_640				DDX55_ENST00000541259.1_Intron|DDX55_ENST00000238146.4_Intron|DDX55_ENST00000538744.1_Intron			Q8NHQ9	DDX55_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 55								ATP binding|ATP-dependent helicase activity|RNA binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000142)|Epithelial(86;0.000637)|all cancers(50;0.00772)		GAATGTGGTATGTGTGTGTGTG	0.520											OREG0022230	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	11	350	---	---	---	---					
TSC22D1	8848	broad.mit.edu	37	13	45148706	45148708	+	In_Frame_Del	DEL	TGC	TGC	-	rs112613609		TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr13:45148706_45148708delTGC	ENST00000458659.2	-	1	1993_1995	c.1503_1505delGCA	c.(1501-1506)caa>ca	p.QQ507del	TSC22D1_ENST00000501704.2_In_Frame_Del_p.QQ507del	NM_183422.3	NP_904358.2	Q15714	T22D1_HUMAN	TSC22 domain family, member 1	507	Gln-rich.				transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity			breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)		ttgttgttgttgctgctgctgct	0.507													8	838	---	---	---	---					
DIAPH3	81624	broad.mit.edu	37	13	60582734	60582734	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr13:60582734delT	ENST00000400324.4	-	9	1178	c.958delA	c.(958-960)ttfs	p.I320fs	DIAPH3_ENST00000377908.2_Frame_Shift_Del_p.I309fs|DIAPH3_ENST00000465066.1_5'UTR|DIAPH3_ENST00000400319.1_Frame_Shift_Del_p.I250fs|DIAPH3_ENST00000400320.1_Frame_Shift_Del_p.I274fs|DIAPH3_ENST00000400330.1_Frame_Shift_Del_p.I320fs|DIAPH3_ENST00000267215.4_Frame_Shift_Del_p.I320fs	NM_001042517.1|NM_001258366.1	NP_001035982.1|NP_001245295.1	Q9NSV4	DIAP3_HUMAN	diaphanous-related formin 3	320	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(7)|liver(1)|lung(20)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	46		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		AATCTGTCAATTTTTTTTTCT	0.323													7	826	---	---	---	---					
RBM26	64062	broad.mit.edu	37	13	79918806	79918807	+	Frame_Shift_Ins	INS	-	-	T			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr13:79918806_79918807insT	ENST00000438737.2	-	15	2621_2622	c.2181_2182insA	c.(2179-2184)aaaggafs	p.G728fs	RBM26_ENST00000438724.1_Frame_Shift_Ins_p.G704fs|RBM26_ENST00000267229.7_Frame_Shift_Ins_p.G701fs			Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	728					mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			NS(1)|biliary_tract(1)|breast(2)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(6)|lung(7)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	33		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		GTACTTACCTGTTTTTTTTTCT	0.332													9	318	---	---	---	---					
TEP1	7011	broad.mit.edu	37	14	20852647	20852647	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr14:20852647delC	ENST00000262715.5	-	23	3282	c.3242delG	c.(3241-3243)gtfs	p.G1081fs	TEP1_ENST00000556935.1_Frame_Shift_Del_p.G973fs	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1081					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding	p.V1082fs*47(1)		NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		AGCTGCCACACCCCCCCACTC	0.587													10	1724	---	---	---	---					
RP11-407N17.3	0	broad.mit.edu	37	14	39746242	39746243	+	Frame_Shift_Ins	INS	-	-	T	rs75842899	byFrequency	TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr14:39746242_39746243insT	ENST00000553728.1	+	6	1986_1987	c.1773_1774insT	c.(1771-1776)ctttttfs	p.LF591fs	RP11-407N17.3_ENST00000603904.1_Frame_Shift_Ins_p.LF27fs|CTAGE5_ENST00000396158.2_Frame_Shift_Ins_p.LF56fs|CTAGE5_ENST00000556148.1_Intron|CTAGE5_ENST00000341749.3_Frame_Shift_Ins_p.LF44fs|CTAGE5_ENST00000557038.1_5'UTR|CTAGE5_ENST00000348007.3_Frame_Shift_Ins_p.LF56fs|CTAGE5_ENST00000341502.5_Frame_Shift_Ins_p.LF56fs|CTAGE5_ENST00000280083.3_Frame_Shift_Ins_p.LF56fs|CTAGE5_ENST00000396165.4_Frame_Shift_Ins_p.LF27fs|CTAGE5_ENST00000553352.1_Frame_Shift_Ins_p.LF27fs																							TTGCTGTTCTCTTTTTTTTGTG	0.371													9	506	---	---	---	---					
FBXO34	55030	broad.mit.edu	37	14	55818554	55818555	+	Frame_Shift_Ins	INS	-	-	T			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr14:55818554_55818555insT	ENST00000313833.4	+	2	1691_1692	c.1446_1447insT	c.(1444-1449)ttttttfs	p.FF482fs	FBXO34_ENST00000440021.1_Frame_Shift_Ins_p.FF482fs	NM_017943.3	NP_060413.2	Q9NWN3	FBX34_HUMAN	F-box protein 34	482										breast(2)|kidney(2)|large_intestine(4)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(3)	22						CAGGGATGTTGTTTTTTTTGCC	0.441													7	885	---	---	---	---					
ARID4A	5926	broad.mit.edu	37	14	58831996	58831997	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr14:58831996_58831997delAG	ENST00000355431.3	+	20	3562_3563	c.3189_3190delAG	c.(3187-3192)caagfs	p.QE1063fs	ARID4A_ENST00000431317.2_Frame_Shift_Del_p.QE1063fs|ARID4A_ENST00000395168.3_Frame_Shift_Del_p.QE1063fs|ARID4A_ENST00000348476.3_Frame_Shift_Del_p.QE1063fs	NM_002892.3	NP_002883.3	P29374	ARI4A_HUMAN	AT rich interactive domain 4A (RBP1-like)	1063					negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	transcriptional repressor complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(4)|endometrium(8)|kidney(2)|large_intestine(14)|lung(19)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	60						TAATTGTACAAGAGAGAGAGAG	0.381													7	636	---	---	---	---					
KCNH5	27133	broad.mit.edu	37	14	63174626	63174626	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr14:63174626delT	ENST00000322893.7	-	11	2835	c.2567delA	c.(2566-2568)acfs	p.N856fs	KCNH5_ENST00000420622.2_3'UTR	NM_139318.3	NP_647479.2	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 5	856					regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(22)|lung(33)|ovary(5)|prostate(2)|skin(17)|upper_aerodigestive_tract(4)|urinary_tract(2)	99				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		TCTTAGTGGGTTTTTGGTCAC	0.463													8	869	---	---	---	---					
SIPA1L1	26037	broad.mit.edu	37	14	72190482	72190484	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr14:72190482_72190484delTCC	ENST00000555818.1	+	16	4738_4740	c.4390_4392delTCC	c.(4390-4392)del	p.S1468del	SIPA1L1_ENST00000358550.2_In_Frame_Del_p.S1447del|SIPA1L1_ENST00000537413.1_In_Frame_Del_p.S922del|SIPA1L1_ENST00000554874.1_3'UTR|SIPA1L1_ENST00000381232.3_In_Frame_Del_p.S1447del	NM_015556.1	NP_056371.1	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like 1	1468	Ser-rich.				actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			NS(1)|breast(4)|central_nervous_system(1)|cervix(1)|endometrium(11)|kidney(1)|large_intestine(22)|liver(2)|lung(25)|ovary(3)|prostate(3)|skin(3)|stomach(1)	78				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		ctcctcctcttcctcctcctcct	0.552													17	953	---	---	---	---					
RBM25	58517	broad.mit.edu	37	14	73572607	73572608	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr14:73572607_73572608delAG	ENST00000261973.7	+	11	1480_1481	c.1195_1196delAG	c.(1195-1197)afs	p.R399fs	RBM25_ENST00000527432.1_Frame_Shift_Del_p.R399fs	NM_021239.2	NP_067062.1	P49756	RBM25_HUMAN	RNA binding motif protein 25	399	Arg-rich.|Glu-rich.|Necessary for nuclear speckle localization.				apoptosis|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|RNA splicing	cytoplasm|nuclear speck	mRNA binding|nucleotide binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(6)|ovary(2)|pancreas(1)	31				BRCA - Breast invasive adenocarcinoma(234;0.00362)|OV - Ovarian serous cystadenocarcinoma(108;0.0688)		agagcgggaaagagagagagag	0.446													11	201	---	---	---	---					
ELMSAN1	91748	broad.mit.edu	37	14	74205926	74205928	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr14:74205926_74205928delCTG	ENST00000286523.5	-	2	1566_1568	c.784_786delCAG	c.(784-786)del	p.Q262del	ELMSAN1_ENST00000394071.2_In_Frame_Del_p.Q262del	NM_194278.3	NP_919254.2			ELM2 and Myb/SANT-like domain containing 1																		GTAGGgctgcctgctgctgctgc	0.650													12	201	---	---	---	---					
FOXN3	1112	broad.mit.edu	37	14	89629149	89629151	+	In_Frame_Del	DEL	GAG	GAG	-	rs139532153		TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr14:89629149_89629151delGAG	ENST00000345097.4	-	7	1196_1198	c.1080_1082delCTC	c.(1078-1083)tca>tc	p.SS360del	FOXN3_ENST00000557258.1_In_Frame_Del_p.SS338del|FOXN3_ENST00000261302.5_In_Frame_Del_p.SS360del|FOXN3_ENST00000555353.1_In_Frame_Del_p.SS338del	NM_001085471.1	NP_001078940.1	O00409	FOXN3_HUMAN	forkhead box N3	360					DNA damage checkpoint|embryo development|G2 phase of mitotic cell cycle|negative regulation of transcription, DNA-dependent|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein C-terminus binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						GTCGTCGGCTGAGGAGGAGGAGG	0.650													11	306	---	---	---	---					
SYNE3	161176	broad.mit.edu	37	14	95921888	95921890	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr14:95921888_95921890delCTC	ENST00000334258.5	-	5	975_977	c.961_963delGAG	c.(961-963)del	p.E321del	SYNE3_ENST00000553340.1_In_Frame_Del_p.E321del|SYNE3_ENST00000557275.1_In_Frame_Del_p.E321del|SYNE3_ENST00000554873.1_In_Frame_Del_p.E78del	NM_152592.3	NP_689805.3			spectrin repeat containing, nuclear envelope family member 3											breast(1)|endometrium(2)|lung(25)	28						CCCGCAGCCGCTCCTCCTCCTCC	0.616													8	920	---	---	---	---					
ATG2B	55102	broad.mit.edu	37	14	96783572	96783572	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr14:96783572delT	ENST00000359933.4	-	20	4013	c.3120delA	c.(3118-3120)aafs	p.K1040fs		NM_018036.5	NP_060506.5	Q96BY7	ATG2B_HUMAN	autophagy related 2B	1040										breast(3)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(11)|liver(1)|lung(26)|ovary(1)|prostate(1)|skin(1)|urinary_tract(7)	64		all_cancers(154;0.0462)|all_epithelial(191;0.123)|Melanoma(154;0.155)		Epithelial(152;0.21)|COAD - Colon adenocarcinoma(157;0.244)		GAGAGTCTAATTTTTTTTTCC	0.368													9	453	---	---	---	---					
IGHV4-39	0	broad.mit.edu	37	14	106877821	106877826	+	RNA	DEL	CTACTG	CTACTG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr14:106877821_106877826delCTACTG	ENST00000390619.2	-	0	217_222																											GTAGTAACTACTACTGCTGATGGAGC	0.607													20	648	---	---	---	---					
SNHG14	0	broad.mit.edu	37	15	25337049	25337050	+	RNA	DEL	GA	GA	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr15:25337049_25337050delGA	ENST00000546682.1	+	0	969				SNHG14_ENST00000549804.2_RNA|SNHG14_ENST00000553108.1_RNA	NR_003361.1																						ACTGGAGCTGGAGAGAGAGAGA	0.500													7	745	---	---	---	---					
SNHG14	0	broad.mit.edu	37	15	25432666	25432666	+	RNA	DEL	G	G	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr15:25432666delG	ENST00000424208.1	+	0	761					NR_003305.1																						TGTGTGTGGTGGGGGGTGCCC	0.552													8	1906	---	---	---	---					
HERC2P9	0	broad.mit.edu	37	15	28900348	28900348	+	RNA	DEL	G	G	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr15:28900348delG	ENST00000528584.1	+	0	14					NR_036443.1																						aaaaaaaaaagaaaaTAACAA	0.403													7	94	---	---	---	---					
SRP14	6727	broad.mit.edu	37	15	40328597	40328599	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr15:40328597_40328599delTGC	ENST00000267884.6	-	5	417_419	c.346_348delGCA	c.(346-348)del	p.A116del	SRP14_ENST00000560773.1_In_Frame_Del_p.A36del|SRP14_ENST00000558720.1_In_Frame_Del_p.A36del|SRP14_ENST00000558527.1_5'UTR	NM_003134.4	NP_003125.3	P37108	SRP14_HUMAN	signal recognition particle 14kDa (homologous Alu RNA binding protein)	116	Ala/Thr-rich.				negative regulation of translational elongation|response to drug|SRP-dependent cotranslational protein targeting to membrane	cytosol|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|endoplasmic reticulum signal peptide binding|protein binding			endometrium(1)|skin(1)|upper_aerodigestive_tract(1)	3		all_cancers(109;7.56e-18)|all_epithelial(112;4.02e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.84e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0505)		ctgcggcaggtgctgctgctgct	0.478													15	480	---	---	---	---					
MGA	23269	broad.mit.edu	37	15	42003383	42003385	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr15:42003383_42003385delCAG	ENST00000219905.7	+	8	3101_3103	c.2920_2922delCAG	c.(2920-2922)del	p.Q981del	MGA_ENST00000389936.4_In_Frame_Del_p.Q981del|MGA_ENST00000570161.1_In_Frame_Del_p.Q981del|MGA_ENST00000566586.1_In_Frame_Del_p.Q981del|MGA_ENST00000545763.1_In_Frame_Del_p.Q981del	NM_001164273.1	NP_001157745.1	Q8IWI9	MGAP_HUMAN	MGA, MAX dimerization protein	981	Gln-rich.					MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(4)|central_nervous_system(3)|endometrium(16)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(18)|lung(33)|ovary(8)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	95		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		GCGGCAGGCACAGCAGCAGCAGC	0.458													7	526	---	---	---	---					
ZNF106	64397	broad.mit.edu	37	15	42742957	42742957	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr15:42742957delA	ENST00000263805.4	-	2	1770	c.1444delT	c.(1444-1446)ccfs	p.S482fs	ZNF106_ENST00000565611.1_Intron|ZNF106_ENST00000565380.1_Intron	NM_022473.1	NP_071918.1			zinc finger protein 106																		TCTCCAGGGGAAAAAAAATTT	0.393													10	1651	---	---	---	---					
SPATA5L1	79029	broad.mit.edu	37	15	45710840	45710841	+	Frame_Shift_Ins	INS	-	-	T			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr15:45710840_45710841insT	ENST00000305560.6	+	7	2153_2154	c.2054_2055insT	c.(2053-2055)tttfs	p.F685fs	SPATA5L1_ENST00000533841.1_3'UTR	NM_024063.2	NP_076968.2	Q9BVQ7	SPA5L_HUMAN	spermatogenesis associated 5-like 1	685						cytoplasm	ATP binding|nucleoside-triphosphatase activity			kidney(2)|large_intestine(3)|lung(1)|ovary(3)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	14		Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;7.31e-17)|GBM - Glioblastoma multiforme(94;6.28e-07)		GCAGAAACCTGTTTTTTTTCTG	0.361													11	487	---	---	---	---					
FAM63B	54629	broad.mit.edu	37	15	59144132	59144134	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr15:59144132_59144134delGCT	ENST00000559228.1	+	8	1787_1789	c.1705_1707delGCT	c.(1705-1707)del	p.A574del	FAM63B_ENST00000450403.2_In_Frame_Del_p.A574del			Q8NBR6	FA63B_HUMAN	family with sequence similarity 63, member B	574	Gln-rich.									central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|liver(2)|lung(4)|ovary(1)|prostate(1)|skin(1)|urinary_tract(1)	15						ACAAGCAGCAGCTGCTGCTGCTG	0.468													7	654	---	---	---	---					
IL16	3603	broad.mit.edu	37	15	81592162	81592164	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr15:81592162_81592164delCCT	ENST00000394660.2	+	14	2855_2857	c.2495_2497delCCT	c.(2494-2499)gcc>g	p.AS832del	IL16_ENST00000394652.2_In_Frame_Del_p.AS131del|IL16_ENST00000302987.4_In_Frame_Del_p.AS832del|IL16_ENST00000560230.1_3'UTR	NM_001172128.1|NM_172217.3	NP_001165599.1|NP_757366.2	Q14005	IL16_HUMAN	interleukin 16	832					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity	p.S792delS(1)|p.S838delS(1)		NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(5)|large_intestine(12)|lung(20)|ovary(3)|skin(3)|stomach(1)|urinary_tract(1)	57						CACATCCGGGcctcctcctcctc	0.586													7	375	---	---	---	---					
RP11-266O8.1	0	broad.mit.edu	37	15	93974509	93974510	+	RNA	DEL	TC	TC	-	rs57286078		TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr15:93974509_93974510delTC	ENST00000543286.1	+	0	545																											TTGGCTGGGTTCtttttttttt	0.431													7	252	---	---	---	---					
RP11-266O8.1	0	broad.mit.edu	37	15	93974510	93974510	+	RNA	DEL	C	C	-	rs57286078		TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr15:93974510delC	ENST00000543286.1	+	0	545																											TGGCTGGGTTCtttttttttt	0.433													22	216	---	---	---	---					
ABCC6P1	0	broad.mit.edu	37	16	18593649	18593649	+	RNA	DEL	A	A	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr16:18593649delA	ENST00000546162.2	+	0	805					NR_003569.1																						ccctgtctcgaaaaaaaaaaa	0.507													15	66	---	---	---	---					
KNOP1	400506	broad.mit.edu	37	16	19725891	19725891	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr16:19725891delT	ENST00000219837.7	-	2	545	c.467delA	c.(466-468)agfs	p.K156fs	AC002550.5_ENST00000565916.1_RNA	NM_001012991.2	NP_001013009.2			lysine-rich nucleolar protein 1																		CTGGGCCCCCTTTTTTTCCTT	0.567													7	678	---	---	---	---					
TNRC6A	27327	broad.mit.edu	37	16	24807240	24807240	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr16:24807240delA	ENST00000395799.3	+	9	3670	c.3541delA	c.(3541-3543)aafs	p.K1182fs	TNRC6A_ENST00000315183.7_Frame_Shift_Del_p.K1182fs	NM_014494.2	NP_055309.2	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1182	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|liver(1)|lung(20)|ovary(3)|skin(2)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	64				GBM - Glioblastoma multiforme(48;0.0394)		TCTGAGTGGCAAAAAAAGGAG	0.398													16	1185	---	---	---	---					
ARHGAP17	55114	broad.mit.edu	37	16	24942180	24942180	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr16:24942180delG	ENST00000289968.6	-	19	2509	c.2440delC	c.(2440-2442)aafs	p.Q814fs	ARHGAP17_ENST00000441763.2_3'UTR|ARHGAP17_ENST00000303665.5_Frame_Shift_Del_p.Q736fs	NM_001006634.1	NP_001006635.1	Q68EM7	RHG17_HUMAN	Rho GTPase activating protein 17	814	Pro-rich.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding			breast(2)|cervix(1)|endometrium(5)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|urinary_tract(2)	30				GBM - Glioblastoma multiforme(48;0.0407)		CCAGGAGGTTGGGGGGGTGGG	0.577													8	1288	---	---	---	---					
IL4R	3566	broad.mit.edu	37	16	27373787	27373789	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr16:27373787_27373789delGAG	ENST00000395762.2	+	11	1373_1375	c.1114_1116delGAG	c.(1114-1116)del	p.E376del	IL4R_ENST00000380922.3_In_Frame_Del_p.E361del|IL4R_ENST00000565915.1_3'UTR|IL4R_ENST00000543915.2_In_Frame_Del_p.E376del|IL4R_ENST00000170630.2_In_Frame_Del_p.E376del	NM_000418.3	NP_000409.1	P24394	IL4RA_HUMAN	interleukin 4 receptor	376	Poly-Glu.				immune response|production of molecular mediator involved in inflammatory response	integral to plasma membrane	identical protein binding|interleukin-4 receptor activity|receptor signaling protein activity			breast(3)|endometrium(2)|kidney(2)|large_intestine(2)|lung(15)|ovary(2)|prostate(2)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	33						GGTGGAGTGTGAGGAGGAGGAGG	0.591													7	439	---	---	---	---					
APOBR	55911	broad.mit.edu	37	16	28507398	28507424	+	In_Frame_Del	DEL	GGGACAGCCTCAGGAGGGGAGGAGGCC	GGGACAGCCTCAGGAGGGGAGGAGGCC	-	rs71657822		TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr16:28507398_28507424delGGGACAGCCTCAGGAGGGGAGGAGGCC	ENST00000564831.1	+	2	1069_1095	c.1036_1062delGGGACAGCCTCAGGAGGGGAGGAGGCC	c.(1036-1062)del	p.GTASGGEEA355del	APOBR_ENST00000328423.5_Splice_Site_p.346_splice|APOBR_ENST00000431282.1_Splice_Site_p.346_splice	NM_018690.3	NP_061160.3	Q0VD83	APOBR_HUMAN	apolipoprotein B receptor	355	Glu-rich.				cholesterol metabolic process|lipid transport	chylomicron|low-density lipoprotein particle|plasma membrane|very-low-density lipoprotein particle				breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(11)|prostate(1)|skin(2)|stomach(1)	29						CGGGGAGGCTGGGACAGCCTCAGGAGGGGAGGAGGCCGGGACAGCCT	0.705													26	105	---	---	---	---					
RABEP2	79874	broad.mit.edu	37	16	28931200	28931202	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr16:28931200_28931202delCTG	ENST00000358201.4	-	3	925_927	c.337_339delCAG	c.(337-339)del	p.Q113del	RABEP2_ENST00000544477.1_In_Frame_Del_p.Q42del|RABEP2_ENST00000561803.1_5'UTR|RABEP2_ENST00000357573.6_In_Frame_Del_p.Q113del	NM_024816.2	NP_079092.2	Q9H5N1	RABE2_HUMAN	rabaptin, RAB GTPase binding effector protein 2	113	Poly-Gln.				endocytosis|protein transport	early endosome	growth factor activity|GTPase activator activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)	16						CCTCACAGTCCTGCTGCTGCTGC	0.640													10	411	---	---	---	---					
TAOK2	9344	broad.mit.edu	37	16	29994531	29994533	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr16:29994531_29994533delGAG	ENST00000308893.4	+	12	2181_2183	c.1138_1140delGAG	c.(1138-1140)del	p.E392del	TAOK2_ENST00000416441.2_In_Frame_Del_p.E219del|TAOK2_ENST00000279394.3_In_Frame_Del_p.E392del|TAOK2_ENST00000543033.1_In_Frame_Del_p.E392del	NM_001252043.1|NM_016151.3	NP_001238972.1|NP_057235.2	Q9UL54	TAOK2_HUMAN	TAO kinase 2	392	Glu-rich.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(3)|skin(1)	22						CAACgaggaagaggaggaggagg	0.611													9	515	---	---	---	---					
RP11-23E10.4	0	broad.mit.edu	37	16	33365420	33365420	+	RNA	DEL	A	A	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr16:33365420delA	ENST00000568520.1	-	0	249																											TACAAACTATAAAAAAACAGA	0.358													7	92	---	---	---	---					
SALL1	6299	broad.mit.edu	37	16	51175656	51175658	+	In_Frame_Del	DEL	GCT	GCT	-	rs13336129	byFrequency	TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr16:51175656_51175658delGCT	ENST00000440970.1	-	2	615_617	c.184_186delAGC	c.(184-186)del	p.S62del	SALL1_ENST00000566102.1_Intron|SALL1_ENST00000251020.4_In_Frame_Del_p.S159del|SALL1_ENST00000541611.1_Intron	NM_001127892.1	NP_001121364.1	Q9NSC2	SALL1_HUMAN	spalt-like transcription factor 1	159					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.S159G(1)		NS(4)|breast(2)|central_nervous_system(2)|endometrium(3)|kidney(5)|large_intestine(25)|lung(61)|ovary(3)|prostate(6)|skin(12)|upper_aerodigestive_tract(3)	126		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			cgccgccgccgctgctgctgctg	0.631													10	335	---	---	---	---					
TOX3	27324	broad.mit.edu	37	16	52473513	52473515	+	In_Frame_Del	DEL	TGC	TGC	-	rs71819850		TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr16:52473513_52473515delTGC	ENST00000219746.9	-	7	1637_1639	c.1353_1355delGCA	c.(1351-1356)caa>ca	p.QQ453del	TOX3_ENST00000407228.3_In_Frame_Del_p.QQ448del	NM_001080430.2	NP_001073899.2	O15405	TOX3_HUMAN	TOX high mobility group box family member 3	453	Gln-rich.				apoptosis|negative regulation of neuron apoptosis|positive regulation of anti-apoptosis|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	chromatin binding|estrogen response element binding|phosphoprotein binding|protein homodimerization activity			NS(2)|endometrium(6)|kidney(1)|lung(8)|prostate(3)|stomach(3)|upper_aerodigestive_tract(1)	24						ctgttgttgttgctgctgctgct	0.552													7	147	---	---	---	---					
SLC9A5	6553	broad.mit.edu	37	16	67300017	67300019	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr16:67300017_67300019delGAG	ENST00000299798.11	+	15	2172_2174	c.2107_2109delGAG	c.(2107-2109)del	p.E708del		NM_004594.2	NP_004585.1	Q14940	SL9A5_HUMAN	solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5	708					regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	27		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)		CGTGGAGTCTGAGGAGGAGGAGG	0.571													10	360	---	---	---	---					
RANBP10	57610	broad.mit.edu	37	16	67763279	67763281	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr16:67763279_67763281delGAG	ENST00000317506.3	-	10	1369_1371	c.1254_1256delCTC	c.(1252-1257)tcg>tc	p.SS420del	RANBP10_ENST00000411657.2_In_Frame_Del_p.SS303del|RANBP10_ENST00000448631.2_In_Frame_Del_p.SS364del|RANBP10_ENST00000602677.1_In_Frame_Del_p.SS420del|RANBP10_ENST00000536251.1_In_Frame_Del_p.SS191del	NM_020850.1	NP_065901.1	Q6VN20	RBP10_HUMAN	RAN binding protein 10	420	Ser-rich.							p.S418S(2)		endometrium(5)|kidney(2)|large_intestine(3)|lung(10)|ovary(2)|skin(1)	23		Acute lymphoblastic leukemia(13;4.34e-06)|all_hematologic(13;0.000643)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00522)|Epithelial(162;0.025)|all cancers(182;0.157)		ggaagaggacgaggaggaggagg	0.567													7	319	---	---	---	---					
NFAT5	10725	broad.mit.edu	37	16	69726420	69726422	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr16:69726420_69726422delCAG	ENST00000349945.1	+	14	3962_3964	c.2410_2412delCAG	c.(2410-2412)del	p.Q812del	NFAT5_ENST00000354436.2_In_Frame_Del_p.Q888del|NFAT5_ENST00000566899.1_In_Frame_Del_p.Q812del|NFAT5_ENST00000393742.2_In_Frame_Del_p.Q812del|NFAT5_ENST00000432919.1_In_Frame_Del_p.Q906del|NFAT5_ENST00000567239.1_In_Frame_Del_p.Q905del	NM_138714.3	NP_619728.2	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5, tonicity-responsive	888					excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity	p.Q804Q(1)|p.Q898Q(1)		NS(1)|breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|lung(11)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						ATCTAATcaacagcagcagcagc	0.473													9	442	---	---	---	---					
NOB1	28987	broad.mit.edu	37	16	69782978	69782980	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr16:69782978_69782980delTCC	ENST00000268802.5	-	6	596_598	c.567_569delGGA	c.(565-570)gaa>ga	p.EE189del		NM_014062.1	NP_054781.1	Q9ULX3	NOB1_HUMAN	NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)	189	Poly-Glu.					nucleus	metal ion binding|protein binding			breast(2)|cervix(1)|endometrium(1)|large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						CCCGTTTTCTTCCTCCTCCTCCT	0.522													15	660	---	---	---	---					
ZFHX3	463	broad.mit.edu	37	16	72991713	72991715	+	In_Frame_Del	DEL	CCA	CCA	-	rs4788682	by1000genomes	TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr16:72991713_72991715delCCA	ENST00000268489.5	-	2	3002_3004	c.2330_2332delTGG	c.(2329-2334)gct>g	p.VA777del	ZFHX3_ENST00000397992.5_Intron	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	777	Poly-Ala.		V -> A (in dbSNP:rs4788682).		muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding	p.V777V(1)		NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				gccgccgcagccaccgccgccgc	0.635													18	659	---	---	---	---					
ADAMTS18	170692	broad.mit.edu	37	16	77334227	77334228	+	Frame_Shift_Ins	INS	-	-	G	rs148849944	by1000genomes	TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr16:77334227_77334228insG	ENST00000282849.5	-	17	3024_3025	c.2606_2607insC	c.(2605-2607)cgcfs	p.R869fs		NM_199355.2	NP_955387.1	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 18	869	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(9)|large_intestine(26)|lung(44)|ovary(2)|pancreas(1)|prostate(1)|skin(19)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	118						TTTTTGTGGCTGGTGGAGTTCC	0.460													9	576	---	---	---	---					
ANKRD11	29123	broad.mit.edu	37	16	89349640	89349641	+	Frame_Shift_Ins	INS	-	-	T			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr16:89349640_89349641insT	ENST00000301030.4	-	9	3769_3770	c.3309_3310insA	c.(3307-3312)aaatgafs	p.*1104fs	ANKRD11_ENST00000378330.2_Frame_Shift_Ins_p.*1104fs	NM_001256183.1|NM_013275.5	NP_001243112.1|NP_037407.4	Q6UB99	ANR11_HUMAN	ankyrin repeat domain 11	1104	Lys-rich.					nucleus				breast(4)|central_nervous_system(3)|endometrium(17)|kidney(2)|large_intestine(18)|lung(20)|ovary(6)|pancreas(1)|prostate(2)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	83		all_hematologic(23;0.00824)|Colorectal(91;0.0475)		Epithelial(1;5.33e-11)|all cancers(4;2.6e-09)|OV - Ovarian serous cystadenocarcinoma(4;2.29e-07)|BRCA - Breast invasive adenocarcinoma(80;0.0142)		TTCTTGTCATCTTTTTTTTCAG	0.465													15	1278	---	---	---	---					
TCF25	22980	broad.mit.edu	37	16	89951019	89951020	+	Frame_Shift_Ins	INS	-	-	A			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr16:89951019_89951020insA	ENST00000263346.8	+	3	440_441	c.384_385insA	c.(382-387)aaaaaafs	p.KK128fs	TCF25_ENST00000563406.1_3'UTR	NM_014972.2	NP_055787.1	Q9BQ70	TCF25_HUMAN	transcription factor 25 (basic helix-loop-helix)	128					heart development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|large_intestine(1)|lung(8)|ovary(3)|skin(1)|urinary_tract(2)	18		all_cancers(9;4.71e-08)|Lung NSC(15;0.000192)|all_lung(18;0.000319)|all_neural(9;0.0122)|all_hematologic(23;0.027)		BRCA - Breast invasive adenocarcinoma(80;0.0288)		TCCGGAAGAAGAAAAAAAAACA	0.446													8	259	---	---	---	---					
C17orf85	55421	broad.mit.edu	37	17	3721809	3721811	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr17:3721809_3721811delTCC	ENST00000158149.3	-	11	1111_1113	c.216_218delGGA	c.(214-219)gaa>ga	p.EE78del	C17orf85_ENST00000389005.4_In_Frame_Del_p.EE358del			Q53F19	CQ085_HUMAN	chromosome 17 open reading frame 85	358							nucleotide binding			endometrium(2)|large_intestine(2)|lung(4)|skin(1)|urinary_tract(1)	10				UCEC - Uterine corpus endometrioid carcinoma (3;0.0725)		ctcttcctcttcctcctcctcct	0.507													11	770	---	---	---	---					
FXR2	9513	broad.mit.edu	37	17	7495872	7495874	+	In_Frame_Del	DEL	CGG	CGG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr17:7495872_7495874delCGG	ENST00000250113.7	-	15	2107_2109	c.1773_1775delCCG	c.(1771-1776)cgt>cg	p.RR591del	MPDU1_ENST00000423172.2_3'UTR	NM_004860.3	NP_004851.2	P51116	FXR2_HUMAN	fragile X mental retardation, autosomal homolog 2	591	Poly-Arg.		R -> P (in dbSNP:rs36013555).			cytosolic large ribosomal subunit	protein binding|RNA binding			NS(1)|breast(2)|endometrium(6)|kidney(1)|large_intestine(7)|lung(8)|prostate(1)	26				READ - Rectum adenocarcinoma(115;0.17)		ACCACGGTTACGGCGGCGGCGGC	0.547													12	1744	---	---	---	---					
KDM6B	23135	broad.mit.edu	37	17	7750177	7750178	+	In_Frame_Ins	INS	-	-	ACCACC	rs61462443		TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr17:7750177_7750178insACCACC	ENST00000254846.5	+	9	1141_1142	c.752_753insACCACC	c.(751-753)tcc>tACCACCcc	p.251_251S>YHP	KDM6B_ENST00000448097.2_In_Frame_Ins_p.251_251S>YHP	NM_001080424.1	NP_001073893.1	O15054	KDM6B_HUMAN	lysine (K)-specific demethylase 6B	251	Pro-rich.				inflammatory response	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			central_nervous_system(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(3)|lung(18)|ovary(1)|pancreas(1)|skin(5)	37						ccaccaccattaccaccaccac	0.614													22	153	---	---	---	---					
MYH8	4626	broad.mit.edu	37	17	10323509	10323509	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr17:10323509delA	ENST00000403437.2	-	3	130	c.36delT	c.(34-36)ttfs	p.F12fs	CTC-297N7.7_ENST00000399342.2_RNA|CTC-297N7.7_ENST00000587182.1_RNA|CTC-297N7.7_ENST00000581304.1_RNA	NM_002472.2	NP_002463.2	P13535	MYH8_HUMAN	myosin, heavy chain 8, skeletal muscle, perinatal	12	Myosin head-like.				muscle filament sliding	cytosol|muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			NS(3)|breast(8)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(61)|ovary(3)|prostate(3)|skin(10)|upper_aerodigestive_tract(2)|urinary_tract(2)	134						CAGCTTCGCCAAAAACAGCCA	0.488									Trismus-Pseudocamptodactyly Syndrome with Cardiac Myxoma and Freckling				7	590	---	---	---	---					
RP11-160E2.17	0	broad.mit.edu	37	17	18988562	18988562	+	RNA	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr17:18988562delT	ENST00000442355.2	+	0	272																											CTGATGTGTGTTTTTTTTTTT	0.279													7	70	---	---	---	---					
SUPT6H	6830	broad.mit.edu	37	17	27027202	27027204	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr17:27027202_27027204delAGC	ENST00000314616.6	+	34	4856_4858	c.4573_4575delAGC	c.(4573-4575)del	p.S1528del	SUPT6H_ENST00000347486.4_In_Frame_Del_p.S1528del	NM_003170.3	NP_003161.2	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog (S. cerevisiae)	1528	Poly-Ser.				chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	Lung NSC(42;0.00431)					CATCACCCCTAGCAGCAGCAGCA	0.537													16	1742	---	---	---	---					
GAS2L2	246176	broad.mit.edu	37	17	34071994	34071996	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr17:34071994_34071996delTCC	ENST00000254466.6	-	6	2547_2549	c.2520_2522delGGA	c.(2518-2523)gaa>ga	p.EE840del	GAS2L2_ENST00000587565.1_In_Frame_Del_p.EE824del	NM_139285.3	NP_644814.1	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	840					cell cycle arrest	cytoplasm|cytoskeleton				central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		ctcctttccttcctcctcctcct	0.616													9	418	---	---	---	---					
KRT10	3858	broad.mit.edu	37	17	38978766	38978768	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr17:38978766_38978768delTCC	ENST00000269576.5	-	1	79_81	c.70_72delGGA	c.(70-72)del	p.G24del	TMEM99_ENST00000301665.3_Intron|TMEM99_ENST00000496847.1_Intron	NM_000421.3	NP_000412.3	P13645	K1C10_HUMAN	keratin 10	24	Gly-rich.|Head.			Missing (in Ref. 1; AAA60544).	epidermis development		protein binding|structural constituent of epidermis			NS(2)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)	11		Breast(137;0.000301)				ctcctccacatcctcctcctcct	0.547													15	293	---	---	---	---					
FKBP10	60681	broad.mit.edu	37	17	39975558	39975559	+	Frame_Shift_Ins	INS	-	-	C	rs137853883		TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr17:39975558_39975559insC	ENST00000321562.4	+	5	928_929	c.824_825insC	c.(823-825)cccfs	p.P275fs	FKBP10_ENST00000544340.1_5'UTR	NM_021939.3	NP_068758.3	Q96AY3	FKB10_HUMAN	FK506 binding protein 10, 65 kDa	275					protein folding	endoplasmic reticulum lumen|membrane	calcium ion binding|FK506 binding|peptidyl-prolyl cis-trans isomerase activity			cervix(1)|endometrium(3)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	14		Breast(137;0.00122)		BRCA - Breast invasive adenocarcinoma(366;0.148)		ACGCTGGAGCTCCCCCCCGGCT	0.634													7	780	---	---	---	---					
COIL	8161	broad.mit.edu	37	17	55028117	55028118	+	Frame_Shift_Ins	INS	-	-	T			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr17:55028117_55028118insT	ENST00000240316.4	-	2	519_520	c.485_486insA	c.(484-486)aaafs	p.K162fs		NM_004645.2	NP_004636.1	P38432	COIL_HUMAN	coilin	162						Cajal body|nucleolus	protein C-terminus binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	15	Breast(9;6.15e-08)					TTTTTCTCTTGTTTTTTTTGCT	0.366													27	1010	---	---	---	---					
SRP68	6730	broad.mit.edu	37	17	74068528	74068530	+	In_Frame_Del	DEL	GCC	GCC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr17:74068528_74068530delGCC	ENST00000307877.2	-	1	204_206	c.43_45delGGC	c.(43-45)del	p.G15del	SRP68_ENST00000355113.5_5'UTR|SRP68_ENST00000539137.1_In_Frame_Del_p.G15del	NM_014230.3	NP_055045.2	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa	15	Poly-Gly.			Missing (in Ref. 1).	response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding			NS(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(5)|lung(4)|ovary(2)|prostate(3)	23						cgccgccactgccgccgccgccg	0.709													10	496	---	---	---	---					
NEDD4L	0	broad.mit.edu	37	18	55992284	55992286	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr18:55992284_55992286delTCC	ENST00000456986.1	+	9	807_809	c.207_209delTCC	c.(205-210)ctt>ct	p.LP69del	NEDD4L_ENST00000382850.4_In_Frame_Del_p.LP190del|NEDD4L_ENST00000586263.1_In_Frame_Del_p.LP182del|NEDD4L_ENST00000456173.2_In_Frame_Del_p.LP69del|NEDD4L_ENST00000431212.2_In_Frame_Del_p.LP69del|NEDD4L_ENST00000356462.6_In_Frame_Del_p.LP190del|NEDD4L_ENST00000435432.2_In_Frame_Del_p.LP69del|NEDD4L_ENST00000400345.3_In_Frame_Del_p.LP190del|NEDD4L_ENST00000256832.7_In_Frame_Del_p.LP69del|NEDD4L_ENST00000589054.1_Intron|NEDD4L_ENST00000357895.5_In_Frame_Del_p.LP182del|NEDD4L_ENST00000256830.9_In_Frame_Del_p.LP190del	NM_001144964.1	NP_001138436.1	Q96PU5	NED4L_HUMAN	neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase	190	C2.				cellular sodium ion homeostasis|excretion|interspecies interaction between organisms|positive regulation of endocytosis|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of protein catabolic process|response to metal ion|sodium ion transport|water homeostasis	cytoplasm	protein binding|sodium channel regulator activity|ubiquitin-protein ligase activity			breast(1)|endometrium(7)|kidney(3)|large_intestine(10)|lung(11)|ovary(1)|prostate(4)	37						AAGAGGAACTTCCTCCTCCTCCT	0.498													11	1249	---	---	---	---					
LMAN1	3998	broad.mit.edu	37	18	57013193	57013194	+	Frame_Shift_Ins	INS	-	-	T			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr18:57013193_57013194insT	ENST00000251047.5	-	8	1629_1630	c.912_913insA	c.(910-915)aaaggafs	p.G305fs		NM_005570.3	NP_005561.1	P49257	LMAN1_HUMAN	lectin, mannose-binding, 1	305					blood coagulation|ER to Golgi vesicle-mediated transport|post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein transport	endoplasmic reticulum membrane|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane	mannose binding|metal ion binding|unfolded protein binding			breast(2)|endometrium(1)|kidney(2)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)	16		Colorectal(73;0.0946)			Antihemophilic Factor(DB00025)	TGGAATTCCTCTTTTTTTTTAT	0.455													8	705	---	---	---	---					
UBXN6	80700	broad.mit.edu	37	19	4454085	4454085	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr19:4454085delT	ENST00000301281.6	-	2	213	c.89delA	c.(88-90)agfs	p.K30fs	UBXN6_ENST00000394765.3_5'UTR|CTB-50L17.9_ENST00000592034.1_RNA	NM_025241.2	NP_079517.1	Q9BZV1	UBXN6_HUMAN	UBX domain protein 6	30						microtubule organizing center|nucleus	protein binding			NS(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(4)|skin(1)	12						TTTGTGGGCCTTTTCCCTGGG	0.667													7	1150	---	---	---	---					
TNFSF9	8744	broad.mit.edu	37	19	6531149	6531151	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr19:6531149_6531151delGCT	ENST00000245817.3	+	1	140_142	c.102_104delGCT	c.(100-105)ggg>gg	p.GL34del		NM_003811.3	NP_003802.1	P41273	TNFL9_HUMAN	tumor necrosis factor (ligand) superfamily, member 9	34					apoptosis|cell proliferation|cell-cell signaling|immune response|signal transduction	extracellular space|integral to membrane	cytokine activity|tumor necrosis factor receptor binding			central_nervous_system(1)|lung(1)|ovary(1)|prostate(1)|skin(1)	5						TGGTCGCGGGgctgctgctgctg	0.768													10	442	---	---	---	---					
DNMT1	1786	broad.mit.edu	37	19	10262139	10262139	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr19:10262139delT	ENST00000340748.4	-	23	2387	c.2152delA	c.(2152-2154)tgfs	p.M718fs	DNMT1_ENST00000540357.1_Frame_Shift_Del_p.M718fs|DNMT1_ENST00000359526.4_Frame_Shift_Del_p.M734fs			P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1	718					chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			breast(5)|endometrium(8)|kidney(5)|large_intestine(21)|lung(11)|ovary(2)|pancreas(1)|prostate(10)|skin(5)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	CCCTGGTGCATTTTTTTGGGT	0.507													9	1188	---	---	---	---					
ZNF443	10224	broad.mit.edu	37	19	12542364	12542364	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr19:12542364delA	ENST00000301547.5	-	4	819	c.622delT	c.(622-624)ggfs	p.W208fs	CTD-3105H18.16_ENST00000595562.1_Intron	NM_005815.4	NP_005806.2	Q9Y2A4	ZN443_HUMAN	zinc finger protein 443	208					induction of apoptosis|regulation of transcription, DNA-dependent|response to stress|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(11)|lung(10)|pancreas(1)|prostate(1)	28						AAACTGGGCCAAAAAAACGCT	0.408													7	1119	---	---	---	---					
HAUS8	93323	broad.mit.edu	37	19	17160706	17160707	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr19:17160706_17160707delGA	ENST00000593360.1	-	10	3044_3045	c.1026_1027delTC	c.(1024-1029)tcgtfs	p.SR342fs	HAUS8_ENST00000448593.2_Frame_Shift_Del_p.SR402fs|HAUS8_ENST00000253669.5_Frame_Shift_Del_p.SR403fs			Q9BT25	HAUS8_HUMAN	HAUS augmin-like complex, subunit 8	403					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole				endometrium(1)|kidney(2)|large_intestine(4)|lung(4)|ovary(1)	12						CTCCCTGAACGAGAGAGAGAGG	0.495													8	1393	---	---	---	---					
ZNF569	148266	broad.mit.edu	37	19	37903917	37903917	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr19:37903917delT	ENST00000316950.6	-	6	2200	c.1643delA	c.(1642-1644)agfs	p.K548fs	ZNF569_ENST00000392149.2_Frame_Shift_Del_p.K548fs|ZNF569_ENST00000392150.2_Frame_Shift_Del_p.K389fs	NM_152484.2	NP_689697.2	Q5MCW4	ZN569_HUMAN	zinc finger protein 569	548					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(5)|endometrium(4)|large_intestine(16)|lung(11)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	40			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTCATAAGGCTTTTCCCCTGT	0.388													7	807	---	---	---	---					
RYR1	6261	broad.mit.edu	37	19	38948159	38948160	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr19:38948159_38948160delTG	ENST00000355481.4	+	17	1945_1946	c.1814_1815delTG	c.(1813-1815)cfs	p.L605fs	RYR1_ENST00000359596.3_Frame_Shift_Del_p.L605fs|RYR1_ENST00000360985.3_Frame_Shift_Del_p.L605fs	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	605	B30.2/SPRY 1.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CTATGCTCCCTGTGTGTGTGTA	0.530													8	1521	---	---	---	---					
ZFP36	7538	broad.mit.edu	37	19	39898948	39898950	+	In_Frame_Del	DEL	CAC	CAC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr19:39898948_39898950delCAC	ENST00000597629.1	+	2	682_684	c.608_610delCAC	c.(607-612)tca>t	p.SP203del	ZFP36_ENST00000248673.3_In_Frame_Del_p.SP197del			P26651	TTP_HUMAN	ZFP36 ring finger protein	197					positive regulation of nuclear-transcribed mRNA poly(A) tail shortening	cytosol|nucleus	AU-rich element binding|DNA binding|mRNA binding|protein binding|single-stranded RNA binding|zinc ion binding			large_intestine(1)|lung(5)|pancreas(1)	7	all_cancers(60;6.54e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.53e-06)|Ovarian(47;0.0512)		Epithelial(26;2.92e-26)|all cancers(26;2.01e-23)|Lung(45;0.000499)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CGCCGGACCTCACCACCACCACC	0.685													8	1554	---	---	---	---					
PNMAL1	55228	broad.mit.edu	37	19	46973195	46973197	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr19:46973195_46973197delCTT	ENST00000313683.10	-	2	1401_1403	c.1096_1098delAAG	c.(1096-1098)del	p.K366del	PNMAL1_ENST00000602246.1_Intron|PNMAL1_ENST00000438932.2_Splice_Site_p.K366_splice	NM_001103149.1|NM_018215.3	NP_001096619.1|NP_060685.2	Q86V59	PNML1_HUMAN	paraneoplastic Ma antigen family-like 1	366										cervix(1)|endometrium(2)|large_intestine(8)|lung(8)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000166)|all cancers(93;0.0014)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		CCAAGCTCACCTTCTTCTTCTTC	0.562													7	1437	---	---	---	---					
SLC8A2	6543	broad.mit.edu	37	19	47935681	47935683	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr19:47935681_47935683delTCC	ENST00000236877.6	-	9	2525_2527	c.2130_2132delGGA	c.(2128-2133)gac>ga	p.ED710del	SLC8A2_ENST00000539381.1_In_Frame_Del_p.ED173del|SLC8A2_ENST00000542837.1_In_Frame_Del_p.ED466del|SLC8A2_ENST00000601757.1_5'UTR	NM_015063.2	NP_055878.1	Q9UPR5	NAC2_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 2	710					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(5)|stomach(1)	31		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		CCGGGACCCGTCCTCCTCCTCCT	0.616													15	785	---	---	---	---					
FUZ	80199	broad.mit.edu	37	19	50310483	50310485	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr19:50310483_50310485delCAG	ENST00000313777.4	-	11	1343_1345	c.1180_1182delCTG	c.(1180-1182)del	p.L394del	FUZ_ENST00000445575.2_Intron|FUZ_ENST00000533418.1_In_Frame_Del_p.L344del|FUZ_ENST00000528094.1_In_Frame_Del_p.L358del	NM_025129.4	NP_079405.2	Q9BT04	FUZZY_HUMAN	fuzzy planar cell polarity protein	394	Leu-rich.				cilium assembly|embryonic body morphogenesis|embryonic skeletal system morphogenesis|establishment of planar polarity|hair follicle development|neural tube closure|protein transport|regulation of smoothened signaling pathway	cytoplasm|cytoskeleton				endometrium(1)|lung(3)	4		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00793)|GBM - Glioblastoma multiforme(134;0.0116)		TCTGGGGAGACAGCAGCAGCAGC	0.635													10	374	---	---	---	---					
TMC4	147798	broad.mit.edu	37	19	54675747	54675749	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr19:54675747_54675749delTCC	ENST00000376591.4	-	2	332_334	c.201_203delGGA	c.(199-204)gat>ga	p.ED67del	TMC4_ENST00000301187.4_In_Frame_Del_p.ED61del	NM_001145303.1|NM_144686.2	NP_001138775.1|NP_653287.1	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4	67	Poly-Glu.					integral to membrane				breast(2)|endometrium(7)|large_intestine(4)|lung(6)|pancreas(1)|skin(1)|urinary_tract(1)	22	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CCTTCCTCCATCCTCCTCCTCCT	0.645													8	583	---	---	---	---					
LILRB1	0	broad.mit.edu	37	19	55146148	55146150	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr19:55146148_55146150delCTC	ENST00000396331.1	+	11	1774_1776	c.1417_1419delCTC	c.(1417-1419)del	p.L479del	LILRB1_ENST00000396315.1_In_Frame_Del_p.L480del|LILRB1_ENST00000324602.7_In_Frame_Del_p.L480del|LILRB1_ENST00000418536.2_In_Frame_Del_p.L463del|LILRB1_ENST00000448689.1_In_Frame_Del_p.L479del|LILRB1_ENST00000434867.2_In_Frame_Del_p.L479del|LILRB1_ENST00000427581.2_In_Frame_Del_p.L529del|LILRB1_ENST00000462628.1_3'UTR|LILRB1_ENST00000396332.4_In_Frame_Del_p.L479del|LILRB1_ENST00000396327.3_In_Frame_Del_p.L480del|LILRB1_ENST00000396321.2_In_Frame_Del_p.L479del|LILRB1_ENST00000396317.1_In_Frame_Del_p.L463del	NM_006669.3	NP_006660.3	Q8NHL6	LIRB1_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1	479					regulation of immune response|response to virus	integral to membrane|plasma membrane	protein phosphatase 1 binding|receptor activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(38)|ovary(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	74				GBM - Glioblastoma multiforme(193;0.0188)		CAtcctactgctcctcctcctcc	0.581										HNSCC(37;0.09)			10	436	---	---	---	---					
BRSK1	84446	broad.mit.edu	37	19	55815036	55815036	+	Splice_Site	DEL	C	C	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr19:55815036delC	ENST00000309383.1	+	12	1405	c.1126_splice	c.e12-1	p.D376_splice	BRSK1_ENST00000326848.7_Splice_Site_p.D71_splice|BRSK1_ENST00000590333.1_Splice_Site_p.D392_splice	NM_032430.1	NP_115806.1	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	376					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity	p.R379fs*9(2)		NS(1)|breast(1)|central_nervous_system(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(12)|lung(15)|ovary(2)|prostate(2)|skin(6)|stomach(1)	48		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		GTCCCTCAGACCCCCCCCGGA	0.582													11	587	---	---	---	---					
DSTN	11034	broad.mit.edu	37	20	17581679	17581680	+	Frame_Shift_Ins	INS	-	-	T			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr20:17581679_17581680insT	ENST00000246069.6	+	2	646_647	c.300_301insT	c.(298-303)atttttfs	p.IF100fs	DSTN_ENST00000543261.1_Frame_Shift_Ins_p.IF83fs|DSTN_ENST00000474024.1_3'UTR	NM_006870.3	NP_006861.1	P60981	DEST_HUMAN	destrin (actin depolymerizing factor)	100	ADF-H.				actin filament severing|actin polymerization or depolymerization		actin binding			endometrium(1)|large_intestine(5)|lung(8)|skin(1)	15						AAGAGTTGATGTTTTTTTTGTG	0.356													17	558	---	---	---	---					
RP4-777D9.2	0	broad.mit.edu	37	20	21146804	21146805	+	RNA	DEL	TG	TG	-	rs3211314		TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr20:21146804_21146805delTG	ENST00000591761.1	-	0	5051				PLK1S1_ENST00000457464.1_RNA																							TTTTTTTTTTTGTCCATGAGGC	0.381													7	145	---	---	---	---					
ZNF337	26152	broad.mit.edu	37	20	25657231	25657232	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr20:25657231_25657232delTG	ENST00000376436.1	-	4	1231_1232	c.692_693delCA	c.(691-693)afs	p.T231fs	RP4-694B14.5_ENST00000455791.1_RNA|ZNF337_ENST00000538750.1_Frame_Shift_Del_p.T199fs|RP4-694B14.5_ENST00000414393.1_RNA|ZNF337_ENST00000252979.5_Frame_Shift_Del_p.T231fs|RP4-694B14.5_ENST00000439498.1_RNA					zinc finger protein 337											breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(8)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						ACTTCTCTCCTGTGTGTGTGTT	0.510													8	636	---	---	---	---					
RP13-329D4.3	0	broad.mit.edu	37	20	26113543	26113543	+	RNA	DEL	A	A	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr20:26113543delA	ENST00000416563.1	-	0	250																											TCTTTGCCTTAACAACATTAT	0.363													7	38	---	---	---	---					
KIF3B	9371	broad.mit.edu	37	20	30898763	30898765	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr20:30898763_30898765delGAG	ENST00000375712.3	+	2	1350_1352	c.1183_1185delGAG	c.(1183-1185)del	p.E399del	KIF3B_ENST00000418717.2_Intron	NM_004798.3	NP_004789.1	O15066	KIF3B_HUMAN	kinesin family member 3B	399	Poly-Glu.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			NS(2)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(2)|kidney(4)|large_intestine(5)|lung(9)|ovary(2)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	36			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GGGTGGggaagaggaggaggagg	0.571													9	299	---	---	---	---					
LPIN3	64900	broad.mit.edu	37	20	39981287	39981287	+	Frame_Shift_Del	DEL	A	A	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr20:39981287delA	ENST00000373257.3	+	10	1496	c.1405delA	c.(1405-1407)aafs	p.K469fs		NM_022896.1	NP_075047.1	Q9BQK8	LPIN3_HUMAN	lipin 3	469					fatty acid metabolic process	nucleus	phosphatidate phosphatase activity			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|liver(2)|lung(7)|ovary(4)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	31		Myeloproliferative disorder(115;0.000739)				GGACCTCACCAAAAACCCCGG	0.562													9	1947	---	---	---	---					
AP001347.6	0	broad.mit.edu	37	21	15441192	15441193	+	RNA	INS	-	-	T	rs148464975		TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr21:15441192_15441193insT	ENST00000428809.1	+	0	177																											TGTATTTTGAATTCTTGGAATT	0.361													9	574	---	---	---	---					
IFNGR2	3460	broad.mit.edu	37	21	34799292	34799292	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr21:34799292delT	ENST00000290219.6	+	4	1162	c.514delT	c.(514-516)ttfs	p.F173fs	IFNGR2_ENST00000381995.1_Frame_Shift_Del_p.F192fs|IFNGR2_ENST00000405436.1_Frame_Shift_Del_p.F94fs	NM_005534.3	NP_005525.2	P38484	INGR2_HUMAN	interferon gamma receptor 2 (interferon gamma transducer 1)	173	Fibronectin type-III 2.				regulation of interferon-gamma-mediated signaling pathway|response to virus	endoplasmic reticulum|integral to plasma membrane	interferon-gamma receptor activity			NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(3)|urinary_tract(1)	13					Interferon gamma-1b(DB00033)	CTCCACGGCCTTTTTTTGTTA	0.458													10	2352	---	---	---	---					
UMODL1	89766	broad.mit.edu	37	21	43496114	43496114	+	Splice_Site	DEL	A	A	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr21:43496114delA	ENST00000408989.2	+	2	77	c.76_splice	c.e2-1	p.E26_splice	UMODL1_ENST00000408910.2_Splice_Site_p.E26_splice|UMODL1_ENST00000400427.1_5'UTR|UMODL1_ENST00000400424.1_5'UTR	NM_173568.3	NP_775839.3	Q5DID0	UROL1_HUMAN	uromodulin-like 1	26						cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			breast(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(5)|lung(22)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	47						CCTCTTTCAGAAAAAGGCCTC	0.567													7	1379	---	---	---	---					
TPTEP1	0	broad.mit.edu	37	22	17127506	17127507	+	RNA	INS	-	-	A			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr22:17127506_17127507insA	ENST00000426585.1	+	0	442																											AGGGCCTAGAGAAAAAAAAAAT	0.421													12	575	---	---	---	---					
HIRA	7290	broad.mit.edu	37	22	19373136	19373138	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr22:19373136_19373138delGCT	ENST00000263208.5	-	12	1491_1493	c.1235_1237delAGC	c.(1234-1239)ctg>c	p.QL412del	HIRA_ENST00000340170.4_In_Frame_Del_p.QL412del|HIRA_ENST00000541063.1_In_Frame_Del_p.QL368del|HIRA_ENST00000546308.1_In_Frame_Del_p.QL368del	NM_003325.3	NP_003316.3	P54198	HIRA_HUMAN	histone cell cycle regulator	412	Poly-Gln.				chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(14)|ovary(2)|prostate(1)|skin(1)	37	Colorectal(54;0.0993)					TTCTGGTCCAGCTGCTGCTGCTG	0.581													10	387	---	---	---	---					
MED15	51586	broad.mit.edu	37	22	20918817	20918819	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr22:20918817_20918819delCAG	ENST00000263205.7	+	6	601_603	c.532_534delCAG	c.(532-534)del	p.Q188del	MED15_ENST00000292733.7_In_Frame_Del_p.Q188del|MED15_ENST00000382974.2_In_Frame_Del_p.Q117del|MED15_ENST00000406969.1_In_Frame_Del_p.Q162del|MED15_ENST00000541476.1_In_Frame_Del_p.Q162del|MED15_ENST00000542773.1_5'UTR|MED15_ENST00000425759.2_In_Frame_Del_p.Q77del	NM_001003891.1	NP_001003891.1	Q96RN5	MED15_HUMAN	mediator complex subunit 15	188	Poly-Gln.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|mediator complex	protein binding			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(2)|lung(8)|ovary(1)|prostate(1)|skin(3)|urinary_tract(1)	25	all_cancers(11;2.07e-24)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)|Epithelial(17;0.209)			ggcggcgctacagcagcagcagc	0.626											OREG0026319	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	175	---	---	---	---					
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22661172	22661173	+	RNA	INS	-	-	C	rs7410785		TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr22:22661172_22661173insC	ENST00000426066.1	+	0	264_265					NR_027293.1																						CATACAGGTTTTCCCCCCCCAC	0.411													7	269	---	---	---	---					
SF3A1	10291	broad.mit.edu	37	22	30742328	30742330	+	In_Frame_Del	DEL	CTG	CTG	-	rs141985009	byFrequency	TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr22:30742328_30742330delCTG	ENST00000215793.7	-	3	518_520	c.364_366delCAG	c.(364-366)del	p.Q122del	SF3A1_ENST00000439242.1_Intron	NM_005877.4	NP_005868.1	Q15459	SF3A1_HUMAN	splicing factor 3a, subunit 1, 120kDa	122	Poly-Gln.				nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nucleoplasm|U2-type spliceosomal complex	protein binding|RNA binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(4)|pancreas(1)|prostate(1)|urinary_tract(1)	29						GCTGGGTGGTCTGCTGCTGCTGC	0.606													10	790	---	---	---	---					
MYH9	4627	broad.mit.edu	37	22	36689419	36689421	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr22:36689419_36689421delCCT	ENST00000216181.5	-	30	4279_4281	c.4049_4051delAGG	c.(4048-4053)gcc>g	p.EA1350del		NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	1350				E -> EE (in Ref. 7).	actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						TTGTGCTTGGCCTCCTCCTCCTC	0.650			T	ALK	ALCL		"""Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"""		Hereditary Macrothrombocytopenia, MYH9-associated				7	571	---	---	---	---					
DNAJB7	150353	broad.mit.edu	37	22	41257115	41257115	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr22:41257115delT	ENST00000307221.4	-	1	1015	c.884delA	c.(883-885)agfs	p.K296fs	XPNPEP3_ENST00000414396.1_Intron|XPNPEP3_ENST00000541156.1_Intron|XPNPEP3_ENST00000482652.1_Intron|XPNPEP3_ENST00000357137.4_Intron	NM_145174.1	NP_660157.1	Q7Z6W7	DNJB7_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 7	296	Poly-Lys.				protein folding		heat shock protein binding|unfolded protein binding			breast(2)|endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|upper_aerodigestive_tract(1)	10						TTTACGCTTCTTTTTTTTCCT	0.378													8	659	---	---	---	---					
RANGAP1	5905	broad.mit.edu	37	22	41650469	41650471	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr22:41650469_41650471delTCC	ENST00000455915.2	-	10	2570_2572	c.1101_1103delGGA	c.(1099-1104)gaa>ga	p.EE367del	RANGAP1_ENST00000407260.4_In_Frame_Del_p.EE312del|RANGAP1_ENST00000356244.3_In_Frame_Del_p.EE367del|RANGAP1_ENST00000405486.1_In_Frame_Del_p.EE367del			P46060	RAGP1_HUMAN	Ran GTPase activating protein 1	367	Asp/Glu-rich (highly acidic).				mitotic prometaphase|signal transduction	condensed chromosome kinetochore|cytosol|nuclear membrane|nuclear pore|soluble fraction|spindle pole	protein binding|Ran GTPase activator activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						ctcttctccttcctcctcctcct	0.562													22	840	---	---	---	---					
TCF20	6942	broad.mit.edu	37	22	42605990	42605992	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr22:42605990_42605992delCTG	ENST00000359486.3	-	1	5456_5458	c.5320_5322delCAG	c.(5320-5322)del	p.Q1774del	TCF20_ENST00000335626.4_In_Frame_Del_p.Q1774del|TCF20_ENST00000404876.1_In_Frame_Del_p.Q75del	NM_005650.1	NP_005641.1	Q9UGU0	TCF20_HUMAN	transcription factor 20 (AR1)	1774					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(7)|large_intestine(13)|lung(22)|ovary(5)|prostate(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(2)|urinary_tract(5)	66						TCTGCTCCTTCTGCTGCTGCTGC	0.601													7	756	---	---	---	---					
ARFGAP3	26286	broad.mit.edu	37	22	43213780	43213780	+	Frame_Shift_Del	DEL	T	T	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chr22:43213780delT	ENST00000263245.5	-	10	1115	c.896delA	c.(895-897)atfs	p.N299fs	ARFGAP3_ENST00000437119.2_Frame_Shift_Del_p.N255fs|ARFGAP3_ENST00000429508.2_Frame_Shift_Del_p.N227fs	NM_001142293.1|NM_014570.4	NP_001135765.1|NP_055385.3	Q9NP61	ARFG3_HUMAN	ADP-ribosylation factor GTPase activating protein 3	299					intracellular protein transport|protein secretion|regulation of ARF GTPase activity|vesicle-mediated transport	cytosol|Golgi membrane	ARF GTPase activator activity|protein transporter activity|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)	11						TGAGTCAACATTTTTTTTGCC	0.363													17	1130	---	---	---	---					
CNKSR2	22866	broad.mit.edu	37	X	21627678	21627680	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chrX:21627678_21627680delGAG	ENST00000425654.2	+	19	3025_3027	c.2545_2547delGAG	c.(2545-2547)del	p.E856del	CNKSR2_ENST00000279451.4_In_Frame_Del_p.E886del|CNKSR2_ENST00000543067.1_In_Frame_Del_p.E837del|CNKSR2_ENST00000379510.3_In_Frame_Del_p.E886del	NM_001168647.1	NP_001162118.1	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras 2	886					regulation of signal transduction	cytoplasm|membrane	protein binding			breast(3)|endometrium(8)|kidney(2)|large_intestine(15)|lung(28)|prostate(2)|upper_aerodigestive_tract(3)	61						ggtggaggaagaggaggaggagg	0.517													8	178	---	---	---	---					
PRRG1	5638	broad.mit.edu	37	X	37312611	37312611	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chrX:37312611delC	ENST00000542554.1	+	5	666	c.394delC	c.(394-396)ccfs	p.P135fs	PRRG1_ENST00000449135.2_Frame_Shift_Del_p.P135fs|TM4SF2_ENST00000465127.1_Intron|PRRG1_ENST00000491253.1_3'UTR|PRRG1_ENST00000543642.1_Frame_Shift_Del_p.P135fs|PRRG1_ENST00000378628.4_Frame_Shift_Del_p.P135fs	NM_001173489.1	NP_001166960.1	O14668	TMG1_HUMAN	proline rich Gla (G-carboxyglutamic acid) 1	135	Poly-Pro.					extracellular region|integral to plasma membrane	calcium ion binding	p.P135fs*3(1)|p.P134fs*19(1)		breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	15						TATCACCCCACCCCCCCCACC	0.488													9	621	---	---	---	---					
DGKK	139189	broad.mit.edu	37	X	50165595	50165596	+	RNA	INS	-	-	AC	rs59226442		TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chrX:50165595_50165596insAC	ENST00000376025.2	-	0	816							Q5KSL6	DGKK_HUMAN	diacylglycerol kinase, kappa						activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|diacylglycerol metabolic process|intracellular signal transduction|platelet activation|response to oxidative stress	cytoplasm|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			central_nervous_system(1)|endometrium(12)|kidney(4)|large_intestine(5)|lung(18)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	45	Ovarian(276;0.236)					TTAAAAGGTAAacacacacaca	0.411													11	45	---	---	---	---					
NUDT11	0	broad.mit.edu	37	X	51239296	51239309	+	Translation_Start_Site	DEL	TCCTCGAGGCAGCC	TCCTCGAGGCAGCC	-	rs78182391		TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chrX:51239296_51239309delTCCTCGAGGCAGCC	ENST00000375992.3	-	0	139_152					NM_018159.3	NP_060629.2	Q96G61	NUD11_HUMAN	nudix (nucleoside diphosphate linked moiety X)-type motif 11							cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding	p.?(5)		breast(1)|central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(2)|prostate(1)|upper_aerodigestive_tract(2)	9	Ovarian(276;0.236)					TTGCACTTCATCCTCGAGGCAGCCTCCTCGAGGC	0.692										HNSCC(48;0.14)			18	41	---	---	---	---					
FAM120C	54954	broad.mit.edu	37	X	54209302	54209303	+	In_Frame_Ins	INS	-	-	GGCGGC			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chrX:54209302_54209303insGGCGGC	ENST00000375180.2	-	1	385_386	c.329_330insGCCGCC	c.(328-330)ccc>cGCCGCCcc	p.109_110insRR	FAM120C_ENST00000328235.4_In_Frame_Ins_p.109_110insRR|FAM120C_ENST00000477084.1_In_Frame_Ins_p.109_110insRR	NM_017848.4	NP_060318.3	Q9NX05	F120C_HUMAN	family with sequence similarity 120C	109										breast(3)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(9)|ovary(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	28						GCAGCTGAGGGGGCGGCGGCGG	0.748													11	17	---	---	---	---					
GNL3L	54552	broad.mit.edu	37	X	54578339	54578341	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chrX:54578339_54578341delGAA	ENST00000336470.4	+	12	1252_1254	c.1113_1115delGAA	c.(1111-1116)ggg>gg	p.GK371del	GNL3L_ENST00000360845.2_In_Frame_Del_p.GK371del	NM_019067.5	NP_061940.1	Q9NVN8	GNL3L_HUMAN	guanine nucleotide binding protein-like 3 (nucleolar)-like	371					ribosome biogenesis	nucleolus	GTP binding			NS(1)|breast(2)|endometrium(7)|kidney(2)|large_intestine(5)|lung(10)|ovary(1)|skin(1)|urinary_tract(1)	30						ACCGTTTGGGGAAGAAGAAGAAG	0.557													11	320	---	---	---	---					
TSIX	0	broad.mit.edu	37	X	73047124	73047125	+	RNA	DEL	AC	AC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chrX:73047124_73047125delAC	ENST00000604411.1	+	0	35085_35086				XIST_ENST00000429829.1_lincRNA	NR_003255.2																						GCCACACATGACACACACACAC	0.470													10	425	---	---	---	---					
XIST	0	broad.mit.edu	37	X	73071845	73071846	+	RNA	INS	-	-	A			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chrX:73071845_73071846insA	ENST00000429829.1	-	0	742_743					NR_001564.2																						GATGGGCGATGAAAAAAAAAAA	0.411													10	119	---	---	---	---					
CD99L2	83692	broad.mit.edu	37	X	149984524	149984526	+	In_Frame_Del	DEL	GTG	GTG	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chrX:149984524_149984526delGTG	ENST00000370377.3	-	3	273_275	c.156_158delCAC	c.(154-159)aca>ac	p.TT52del	CD99L2_ENST00000346693.4_5'UTR|CD99L2_ENST00000355149.3_Intron|CD99L2_ENST00000466436.1_Intron|CD99L2_ENST00000437787.2_In_Frame_Del_p.TT52del	NM_001242614.1|NM_031462.3	NP_001229543.1|NP_113650.2	Q8TCZ2	C99L2_HUMAN	CD99 molecule-like 2	52	Poly-Thr.				cell adhesion	cell junction|integral to membrane				endometrium(4)|large_intestine(4)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					CCTATTGGTTGTGGTGGTGGTGG	0.552													7	783	---	---	---	---					
RBMY2EP	0	broad.mit.edu	37	Y	23563322	23563323	+	RNA	DEL	AC	AC	-			TCGA-F2-7276-01A-11D-2154-08	TCGA-F2-7276-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	dc12b1a6-7f32-40c4-950c-e99392389a8e	b1a1bd8b-59e5-47d3-8a7f-65495eaacb3f	g.chrY:23563322_23563323delAC	ENST00000444169.1	-	0	86					NR_001574.2																						ATATGAAAATacacacacacac	0.302													9	79	---	---	---	---					
