Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
IGHM	0	broad.mit.edu	37	14	106321805	106321805	+	RNA	SNP	C	C	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr14:106321805C>T	ENST00000390559.2	-	0	428																											ACACCTGAATCTGCCGGGGAC	0.652000													29	168					0	0	1	0	0
STAU1	6780	broad.mit.edu	37	20	47733693	47733693	+	Silent	SNP	G	G	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr20:47733693G>A	ENST00000371828.3	-	12	1864	c.1377C>T	c.(1375-1377)atC>atT	p.I459I	STAU1_ENST00000371856.2_Silent_p.I534I|STAU1_ENST00000340954.7_Silent_p.I453I|STAU1_ENST00000371792.1_Silent_p.I451I|STAU1_ENST00000347458.5_Silent_p.I453I|STAU1_ENST00000371802.1_Silent_p.I459I|STAU1_ENST00000360426.4_Silent_p.I453I	NM_001037328.1|NM_004602.2	NP_001032405.1|NP_004593.2	O95793	STAU1_HUMAN	staufen double-stranded RNA binding protein 1	534						microtubule associated complex|rough endoplasmic reticulum|stress granule	double-stranded RNA binding			breast(3)|endometrium(2)|kidney(2)|large_intestine(2)|liver(1)|lung(6)|ovary(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	23			BRCA - Breast invasive adenocarcinoma(12;0.000644)|Colorectal(8;0.198)			CATCCTTGCCGATACCATGGC	0.478000													5	323					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145311839	145311839	+	Missense_Mutation	SNP	A	A	T	rs58277049		TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr1:145311839A>T	ENST00000369338.1	+	10	1278	c.1088A>T	c.(1087-1089)cAg>cTg	p.Q363L	NBPF10_ENST00000369339.2_Intron|RP11-458D21.5_ENST00000468030.1_Intron|NBPF10_ENST00000342960.5_Intron			A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	636										NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		CAGGACTCACAGGATAGATGT	0.473000													4	174					0	0	1	0	0
CATSPER4	378807	broad.mit.edu	37	1	26520380	26520380	+	Splice_Site	SNP	G	G	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr1:26520380G>A	ENST00000456354.2	+	3	526		c.e3+1			NM_198137.1	NP_937770.1	Q7RTX7	CTSR4_HUMAN	cation channel, sperm associated 4						cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			NS(1)|breast(3)|endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(2)	27		all_cancers(24;2.05e-18)|Colorectal(325;0.000147)|Renal(390;0.00211)|all_lung(284;0.00218)|Lung NSC(340;0.00239)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.051)|Breast(348;0.0589)|all_neural(195;0.0687)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;3.52e-26)|Colorectal(126;1.34e-08)|COAD - Colon adenocarcinoma(152;9.31e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.000755)|BRCA - Breast invasive adenocarcinoma(304;0.000995)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00878)|READ - Rectum adenocarcinoma(331;0.0649)		TTTCTGGAAGGTGAGATCCTG	0.522000													34	260					0	0	1	0	0
ZNF676	163223	broad.mit.edu	37	19	22363559	22363559	+	Missense_Mutation	SNP	C	C	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr19:22363559C>A	ENST00000397121.2	-	3	1277	c.960G>T	c.(958-960)tgG>tgT	p.W320C		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	320					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				GGCTTGAGGACCAGCTGAAGG	0.433000													7	376					6.94344e-10	7.58362e-10	1	1	0
ZIC1	7545	broad.mit.edu	37	3	147128727	147128727	+	Missense_Mutation	SNP	T	T	G			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr3:147128727T>G	ENST00000282928.4	+	1	1557	c.828T>G	c.(826-828)tgT>tgG	p.C276W		NM_003412.3	NP_003403.2	Q15915	ZIC1_HUMAN	Zic family member 1	276					behavior|brain development|cell differentiation|inner ear morphogenesis|pattern specification process|positive regulation of protein import into nucleus|positive regulation of transcription, DNA-dependent|regulation of smoothened signaling pathway	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(4)|cervix(1)|endometrium(2)|large_intestine(8)|lung(38)|ovary(1)|prostate(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	63						GGGAGGAGTGTCCGCGCGAGG	0.577000													36	399					0	0	1	0	0
GPR114	221188	broad.mit.edu	37	16	57604382	57604382	+	Silent	SNP	C	C	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr16:57604382C>T	ENST00000340339.4	+	10	1666	c.1143C>T	c.(1141-1143)taC>taT	p.Y381Y	GPR114_ENST00000349457.3_Silent_p.Y381Y|GPR114_ENST00000394361.4_Intron	NM_153837.1	NP_722579.1	Q8IZF4	GP114_HUMAN	G protein-coupled receptor 114	381					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(5)|ovary(2)|stomach(1)|urinary_tract(1)	23						GCTCGGTATACGGACCCTGCA	0.622000													4	241					0	0	1	0	0
TBP	6908	broad.mit.edu	37	6	170871058	170871058	+	Silent	SNP	G	G	A	rs113440919		TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr6:170871058G>A	ENST00000392092.2	+	3	513	c.234G>A	c.(232-234)caG>caA	p.Q78Q	TBP_ENST00000540980.1_Silent_p.Q58Q|TBP_ENST00000230354.6_Silent_p.Q78Q	NM_003194.4	NP_003185.1	P20226	TBP_HUMAN	TATA box binding protein	78	Poly-Gln.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding			breast(2)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(2)|lung(9)|ovary(1)|prostate(4)|urinary_tract(1)	26		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		agcagcagcagcagcagcagc	0.577000													10	194					0	0	1	0	0
SLC16A3	9123	broad.mit.edu	37	17	80194631	80194631	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr17:80194631C>T	ENST00000581287.1	+	2	2572	c.250C>T	c.(250-252)Cgc>Tgc	p.R84C	SLC16A3_ENST00000584781.1_3'UTR|SLC16A3_ENST00000392341.1_Missense_Mutation_p.R84C|SLC16A3_ENST00000582743.1_Missense_Mutation_p.R84C|SLC16A3_ENST00000392339.1_Missense_Mutation_p.R84C	NM_001206951.1|NM_001206952.1	NP_001193880.1|NP_001193881.1	O15427	MOT4_HUMAN	solute carrier family 16 (monocarboxylate transporter), member 3	84					blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	actin cytoskeleton|integral to plasma membrane|membrane fraction|nuclear membrane	secondary active monocarboxylate transmembrane transporter activity|symporter activity			endometrium(2)|kidney(1)|lung(3)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	9	Breast(20;0.00285)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0149)		Pyruvic acid(DB00119)	GTGCGTGAACCGCTTTGGCTG	0.662000											OREG0024821	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	62	420					0	0	1	0	0
URB2	9816	broad.mit.edu	37	1	229773136	229773136	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr1:229773136G>A	ENST00000258243.2	+	4	2912	c.2776G>A	c.(2776-2778)Gtc>Atc	p.V926I		NM_014777.2	NP_055592.2	Q14146	URB2_HUMAN	URB2 ribosome biogenesis 2 homolog (S. cerevisiae)	926						nucleolus				breast(1)|central_nervous_system(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(33)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(6)	73						GTCCATGGCCGTCACCAAACT	0.483000													7	926					0	0	1	0	0
NCOR2	9612	broad.mit.edu	37	12	124887093	124887093	+	Silent	SNP	C	C	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr12:124887093C>T	ENST00000356219.3	-	15	1652	c.1497G>A	c.(1495-1497)caG>caA	p.Q499Q	NCOR2_ENST00000429285.2_Silent_p.Q498Q|NCOR2_ENST00000405201.1_Silent_p.Q499Q|NCOR2_ENST00000404621.1_Silent_p.Q498Q|NCOR2_ENST00000404121.2_Silent_p.Q69Q|NCOR2_ENST00000397355.1_Silent_p.Q499Q	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	499	Poly-Gln.				cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity	p.Q499Q(9)		breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		gctgctgctgctgttgttgct	0.617000													3	42					0	0	1	0	0
DNAJB11	51726	broad.mit.edu	37	3	186299863	186299863	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr3:186299863G>A	ENST00000439351.1	+	7	1608	c.679G>A	c.(679-681)Gaa>Aaa	p.E227K	DNAJB11_ENST00000265028.3_Missense_Mutation_p.E227K			Q9UBS4	DJB11_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 11	227					protein folding	endoplasmic reticulum lumen	heat shock protein binding			breast(1)|central_nervous_system(1)|kidney(2)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)|urinary_tract(2)	15	all_cancers(143;2.84e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;1.44e-20)	GBM - Glioblastoma multiforme(93;0.0476)		CTTTATTGGAGAAGGTGAAAT	0.388000													10	109					0	0	1	0	0
HSD17B7	51478	broad.mit.edu	37	1	162769603	162769603	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr1:162769603G>A	ENST00000367917.3	+	5	586	c.518G>A	c.(517-519)aGt>aAt	p.S173N	HSD17B7_ENST00000485405.1_3'UTR|HSD17B7_ENST00000254521.3_Missense_Mutation_p.S173N			P56937	DHB7_HUMAN	hydroxysteroid (17-beta) dehydrogenase 7	173					cholesterol biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	3-keto sterol reductase activity|estradiol 17-beta-dehydrogenase activity	p.S173N(4)		endometrium(3)|kidney(2)|large_intestine(1)|lung(1)|ovary(1)|skin(1)	9	all_hematologic(112;0.115)				NADH(DB00157)	TCATCTCGCAGTGCAAGGAAA	0.458000													8	181					0	0	1	0	0
GPR124	25960	broad.mit.edu	37	8	37690642	37690642	+	Missense_Mutation	SNP	C	C	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr8:37690642C>A	ENST00000315215.7	+	9	1575	c.1212C>A	c.(1210-1212)gaC>gaA	p.D404E	GPR124_ENST00000412232.2_Missense_Mutation_p.D404E			Q96PE1	GP124_HUMAN	G protein-coupled receptor 124	404					central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(16)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			GCCGGTGTGACCGTGCCGGCC	0.667000													50	248					1.21353e-23	1.40515e-23	1	1	0
NAB2	4665	broad.mit.edu	37	12	57485472	57485472	+	Silent	SNP	C	C	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr12:57485472C>T	ENST00000300131.3	+	2	1026	c.648C>T	c.(646-648)gtC>gtT	p.V216V	NAB2_ENST00000554718.1_3'UTR|NAB2_ENST00000357680.4_Silent_p.V216V|NAB2_ENST00000342556.6_Silent_p.V216V	NM_005967.3	NP_005958.1	Q15742	NAB2_HUMAN	NGFI-A binding protein 2 (EGR1 binding protein 2)	216					cell proliferation|negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	transcription corepressor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	20						GGGGAGGAGTCCCTGAGGGGA	0.687000													20	210					0	0	1	0	0
NTRK1	4914	broad.mit.edu	37	1	156845430	156845430	+	Silent	SNP	C	C	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr1:156845430C>T	ENST00000368196.3	+	11	1575	c.1455C>T	c.(1453-1455)atC>atT	p.I485I	NTRK1_ENST00000392302.2_Silent_p.I455I|NTRK1_ENST00000358660.3_Silent_p.I485I|NTRK1_ENST00000524377.1_Silent_p.I491I	NM_001012331.1	NP_001012331.1	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	491	Interaction with SQSTM1 (By similarity).				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(35)|ovary(8)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	74	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	GCCACATCATCGAGAACCCAC	0.577000			T	"""TPM3, TPR, TFG"""	papillary thyroid					TSP Lung(10;0.080)			26	268					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091841	29091841	+	Silent	SNP	G	G	A	rs146546850	byFrequency	TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr22:29091841G>A	ENST00000544772.1	-	12	1889	c.453C>T	c.(451-453)tcC>tcT	p.S151S	CHEK2_ENST00000348295.3_Silent_p.S343S|CHEK2_ENST00000403642.1_Silent_p.S281S|CHEK2_ENST00000382580.2_Silent_p.S415S|CHEK2_ENST00000328354.6_Silent_p.S372S|CHEK2_ENST00000382578.1_Silent_p.S281S|CHEK2_ENST00000404276.1_Silent_p.S372S|CHEK2_ENST00000405598.1_Silent_p.S372S|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000402731.1_Silent_p.S343S|CHEK2_ENST00000382565.1_Intron	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	372	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.S372S(8)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCAAAATCTTGGAGTGCCCAA	0.413000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					5	216					0	0	1	0	0
SLC17A6	57084	broad.mit.edu	37	11	22382454	22382454	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr11:22382454C>A	ENST00000263160.3	+	5	1022	c.585C>A	c.(583-585)taC>taA	p.Y195*		NM_020346.2	NP_065079.1	Q9P2U8	VGLU2_HUMAN	solute carrier family 17 (vesicular glutamate transporter), member 6	195					sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|lung(28)|ovary(3)|skin(4)|upper_aerodigestive_tract(3)	50						GTGTGACCTACCCAGCATGTC	0.502000													12	114					4.3838e-07	4.75426e-07	1	1	0
MLLT3	4300	broad.mit.edu	37	9	20414373	20414373	+	Silent	SNP	G	G	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr9:20414373G>A	ENST00000380338.4	-	5	757	c.471C>T	c.(469-471)agC>agT	p.S157S	MLLT3_ENST00000429426.2_Silent_p.S154S|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	157	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S157S(5)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.527000			T	MLL	ALL								6	185					0	0	1	0	0
NMT2	9397	broad.mit.edu	37	10	15183511	15183511	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr10:15183511C>T	ENST00000378150.1	-	2	171	c.74G>A	c.(73-75)aGa>aAa	p.R25K	NMT2_ENST00000378165.4_Silent_p.Q52Q|NMT2_ENST00000540259.1_5'UTR|NMT2_ENST00000535341.1_Missense_Mutation_p.R25K			O60551	NMT2_HUMAN	N-myristoyltransferase 2	50					N-terminal protein myristoylation|protein lipoylation	Golgi apparatus|plasma membrane	glycylpeptide N-tetradecanoyltransferase activity			breast(3)|endometrium(1)|kidney(4)|large_intestine(3)|lung(6)|ovary(1)|upper_aerodigestive_tract(3)	21						tttttctcttctgtttcttct	0.418000													15	170					0	0	1	0	0
LRP1B	53353	broad.mit.edu	37	2	141533745	141533745	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr2:141533745C>T	ENST00000389484.3	-	33	6393	c.5422G>A	c.(5422-5424)Gga>Aga	p.G1808R		NM_018557.2	NP_061027.2	Q9NZR2	LRP1B_HUMAN	low density lipoprotein receptor-related protein 1B	1808					protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			NS(5)|autonomic_ganglia(1)|biliary_tract(1)|breast(3)|central_nervous_system(7)|endometrium(25)|haematopoietic_and_lymphoid_tissue(10)|kidney(27)|large_intestine(98)|liver(4)|lung(337)|ovary(15)|pancreas(6)|prostate(11)|skin(30)|stomach(2)|upper_aerodigestive_tract(19)|urinary_tract(5)	606		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GGGTTTCTTCCGTCTCTTTTG	0.388000										TSP Lung(27;0.18)			20	202					0	0	1	0	0
SNAP25	6616	broad.mit.edu	37	20	10273546	10273546	+	Silent	SNP	C	C	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr20:10273546C>T	ENST00000304886.2	+	5	388	c.180C>T	c.(178-180)gtC>gtT	p.V60V	SNAP25-AS1_ENST00000453544.1_RNA|SNAP25_ENST00000254976.2_Intron|SNAP25-AS1_ENST00000421143.2_RNA	NM_003081.3	NP_003072.2	P60880	SNP25_HUMAN	synaptosomal-associated protein, 25kDa	60	Interaction with CENPF (By similarity).|t-SNARE coiled-coil homology 1.				energy reserve metabolic process|glutamate secretion|neurotransmitter uptake|synaptic vesicle docking involved in exocytosis	cell junction|growth cone|perinuclear region of cytoplasm|synapse|synaptosome				endometrium(1)|large_intestine(2)|lung(8)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)	18					Botulinum Toxin Type A(DB00083)	TCGATCGTGTCGAAGAAGGCA	0.403000													52	273					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367767	145367767	+	Missense_Mutation	SNP	G	G	A	rs77484671		TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr1:145367767G>A	ENST00000342960.5	+	83	10398	c.10363G>A	c.(10363-10365)Gaa>Aaa	p.E3455K	NBPF10_ENST00000369339.2_Intron|NBPF10_ENST00000369338.1_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3455								p.E3455K(5)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		atcaaagaaggaaagaagaag	0.423000													6	188					0	0	1	0	0
CCDC88B	283234	broad.mit.edu	37	11	64120286	64120286	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr11:64120286C>T	ENST00000356786.5	+	20	3471	c.3427C>T	c.(3427-3429)Cgc>Tgc	p.R1143C	CCDC88B_ENST00000463837.1_3'UTR|CCDC88B_ENST00000301897.4_5'UTR|CCDC88B_ENST00000359902.2_Missense_Mutation_p.R295C	NM_032251.5	NP_115627.6	A6NC98	CC88B_HUMAN	coiled-coil domain containing 88B	1143					microtubule cytoskeleton organization	cytoplasm	microtubule binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(12)|ovary(3)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						AGAGCGTGAACGCCTGATGCA	0.682000													13	144					0	0	1	0	0
GRIA1	0	broad.mit.edu	37	5	153035414	153035414	+	Missense_Mutation	SNP	C	C	G			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr5:153035414C>G	ENST00000285900.5	+	5	1024	c.681C>G	c.(679-681)caC>caG	p.H227Q	GRIA1_ENST00000518783.1_Missense_Mutation_p.H237Q|GRIA1_ENST00000448073.4_Missense_Mutation_p.H237Q|GRIA1_ENST00000521843.2_Missense_Mutation_p.H158Q|GRIA1_ENST00000340592.5_Missense_Mutation_p.H227Q|GRIA1_ENST00000518142.1_Missense_Mutation_p.H147Q	NM_000827.3|NM_001258019.1	NP_000818.2|NP_001244948.1	P42261	GRIA1_HUMAN	glutamate receptor, ionotropic, AMPA 1	227					synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|dendritic spine|endocytic vesicle membrane|endoplasmic reticulum membrane|neuronal cell body|postsynaptic density|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity|PDZ domain binding			NS(1)|breast(4)|endometrium(7)|kidney(3)|large_intestine(24)|liver(2)|lung(23)|ovary(4)|pancreas(1)|prostate(5)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(2)	81		Medulloblastoma(196;0.0391)|all_neural(177;0.16)|all_hematologic(541;0.21)	Kidney(363;0.000173)|KIRC - Kidney renal clear cell carcinoma(527;0.000785)		Desflurane(DB01189)|Enflurane(DB00228)|Halothane(DB01159)|Isoflurane(DB00753)|L-Glutamic Acid(DB00142)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	TCGGCTACCACTACATTCTTG	0.448000													34	251					0	0	1	0	0
DGAT2	84649	broad.mit.edu	37	11	75508352	75508352	+	Missense_Mutation	SNP	T	T	G			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr11:75508352T>G	ENST00000228027.7	+	6	1044	c.784T>G	c.(784-786)Ttt>Gtt	p.F262V	DGAT2_ENST00000376262.3_Missense_Mutation_p.F219V	NM_032564.4	NP_115953.2	Q96PD7	DGAT2_HUMAN	diacylglycerol O-acyltransferase 2	262					glycerol metabolic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	diacylglycerol O-acyltransferase activity			endometrium(3)|large_intestine(5)|lung(5)|prostate(2)|skin(2)	17	Ovarian(111;0.103)					CCGCAAGGGCTTTGTGAAACT	0.617000													30	332					0	0	1	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22664141	22664141	+	RNA	SNP	G	G	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr22:22664141G>A	ENST00000426066.1	+	0	664					NR_027293.1																						AAATTTGAAGGTGCTGTGATT	0.448000													8	306					0	0	1	0	0
HSD17B7P2	0	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													7	178					0	0	1	0	0
RRN3P2	0	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													19	209					0	0	1	0	0
CHEK2	11200	broad.mit.edu	37	22	29091840	29091840	+	Missense_Mutation	SNP	T	T	C	rs142470496	byFrequency	TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr22:29091840T>C	ENST00000544772.1	-	12	1890	c.454A>G	c.(454-456)Aag>Gag	p.K152E	CHEK2_ENST00000348295.3_Missense_Mutation_p.K344E|CHEK2_ENST00000403642.1_Missense_Mutation_p.K282E|CHEK2_ENST00000382580.2_Missense_Mutation_p.K416E|CHEK2_ENST00000328354.6_Missense_Mutation_p.K373E|CHEK2_ENST00000382578.1_Missense_Mutation_p.K282E|CHEK2_ENST00000404276.1_Missense_Mutation_p.K373E|CHEK2_ENST00000405598.1_Missense_Mutation_p.K373E|CHEK2_ENST00000382566.1_3'UTR|CHEK2_ENST00000402731.1_Missense_Mutation_p.K344E|CHEK2_ENST00000382565.1_Intron	NM_001257387.1	NP_001244316.1	O96017	CHK2_HUMAN	checkpoint kinase 2	373	FHA.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity	p.K373E(9)		central_nervous_system(17)|endometrium(2)|kidney(11)|large_intestine(2)|lung(11)|ovary(1)|prostate(4)|stomach(2)	50						CCCAAAATCTTGGAGTGCCCA	0.418000			F			breast		Direct reversal of damage;Other conserved DNA damage response genes					5	218					0	0	1	0	0
OR14A16	284532	broad.mit.edu	37	1	247978219	247978219	+	Missense_Mutation	SNP	A	A	C			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr1:247978219A>C	ENST00000357627.1	-	1	812	c.813T>G	c.(811-813)atT>atG	p.I271M		NM_001001966.1	NP_001001966.1	Q8NHC5	O14AG_HUMAN	olfactory receptor, family 14, subfamily A, member 16	271					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(32)|skin(2)|stomach(1)	45						AGAACACAGAAATTACAGCAT	0.418000													30	173					0	0	1	0	0
GFRA1	2674	broad.mit.edu	37	10	118030450	118030450	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr10:118030450C>T	ENST00000439649.3	-	3	585	c.218G>A	c.(217-219)cGc>cAc	p.R73H	GFRA1_ENST00000369236.1_Missense_Mutation_p.R73H|GFRA1_ENST00000355422.6_Missense_Mutation_p.R73H	NM_001145453.1	NP_001138925.1	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1	73					axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			endometrium(2)|large_intestine(10)|liver(1)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|stomach(1)	26		Lung NSC(174;0.21)		all cancers(201;0.0337)		CATGGCGCTGCGGCACTCATC	0.607000													4	269					0	0	1	0	0
FRAS1	80144	broad.mit.edu	37	4	79460452	79460452	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr4:79460452G>A	ENST00000264895.6	+	73	11743	c.11303G>A	c.(11302-11304)cGc>cAc	p.R3768H		NM_025074.6	NP_079350.5	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	3763					cell communication	integral to membrane|plasma membrane	metal ion binding			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(14)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(5)|lung(54)|prostate(7)|skin(2)|urinary_tract(4)	103						TCCTAGGACCGCAATCAGCCA	0.438000													4	252					0	0	1	0	0
ANKMY1	51281	broad.mit.edu	37	2	241465801	241465801	+	Missense_Mutation	SNP	A	A	G			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr2:241465801A>G	ENST00000391987.1	-	6	1114	c.748T>C	c.(748-750)Ttt>Ctt	p.F250L	ANKMY1_ENST00000361678.4_Intron|ANKMY1_ENST00000462004.1_5'UTR|ANKMY1_ENST00000405523.3_Intron|ANKMY1_ENST00000373318.2_Intron|ANKMY1_ENST00000405002.1_Intron|ANKMY1_ENST00000272972.3_Missense_Mutation_p.F250L|ANKMY1_ENST00000536462.1_Intron|ANKMY1_ENST00000373320.4_Intron|ANKMY1_ENST00000406958.1_Intron|ANKMY1_ENST00000401804.1_Missense_Mutation_p.F339L|ANKMY1_ENST00000403283.1_Intron			Q9P2S6	ANKY1_HUMAN	ankyrin repeat and MYND domain containing 1	250							zinc ion binding			central_nervous_system(1)|endometrium(5)|large_intestine(4)|lung(14)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	30		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;1.03e-30)|all cancers(36;4.78e-28)|OV - Ovarian serous cystadenocarcinoma(60;1.45e-14)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;7.8e-06)|Lung(119;0.00271)|LUSC - Lung squamous cell carcinoma(224;0.01)|Colorectal(34;0.0101)|COAD - Colon adenocarcinoma(134;0.0476)		CAGGGTGCAAAGCCACTGCGC	0.532000													25	213					0	0	1	0	0
MKX	283078	broad.mit.edu	37	10	28024186	28024186	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr10:28024186G>A	ENST00000375790.5	-	4	898	c.466C>T	c.(466-468)Cgg>Tgg	p.R156W	MKX_ENST00000419761.1_Missense_Mutation_p.R156W			Q8IYA7	MKX_HUMAN	mohawk homeobox	156					muscle organ development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity	p.R156W(1)		NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|ovary(2)|skin(2)	16						ACGCTAAGCCGTTCAGCATTG	0.378000													24	264					0	0	1	0	0
CCT6P1	0	broad.mit.edu	37	7	65226641	65226641	+	RNA	SNP	G	G	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr7:65226641G>T	ENST00000442266.1	+	0	1167																											AGGTTCTTGCGCAGAATTCTG	0.383000													3	65					0.00909568	0.00915513	1	1	0
RP11-156P1.3	0	broad.mit.edu	37	17	45128735	45128735	+	RNA	SNP	T	T	C	rs138973461	by1000genomes	TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr17:45128735T>C	ENST00000575173.1	-	0	418																											GAAATACTAATGATTTTTATT	0.323000													7	272					0	0	1	0	0
TUBB8P7	0	broad.mit.edu	37	16	90162513	90162513	+	RNA	SNP	T	T	C			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr16:90162513T>C	ENST00000564451.1	+	0	1866				TUBB8P7_ENST00000567960.1_RNA														p.N415N(2)									GCAACATGAATGACCTGGTGT	0.537000													10	377					0	0	1	0	0
ZNF727	442319	broad.mit.edu	37	7	63529386	63529386	+	Missense_Mutation	SNP	T	T	G			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr7:63529386T>G	ENST00000550760.3	+	2	300	c.121T>G	c.(121-123)Ttc>Gtc	p.F41V	RP11-3N2.13_ENST00000445978.1_RNA	NM_001159522.1	NP_001152994.1	A8MUV8	ZN727_HUMAN	zinc finger protein 727	41	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding	p.F41V(1)		endometrium(3)|kidney(2)|skin(1)|stomach(1)|urinary_tract(1)	8						CGGAAACCTGTTCTCCTTGGG	0.383000													4	30					0	0	1	0	0
ARHGEF17	9828	broad.mit.edu	37	11	73022572	73022572	+	Silent	SNP	C	C	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr11:73022572C>T	ENST00000263674.3	+	1	3239	c.2889C>T	c.(2887-2889)ccC>ccT	p.P963P		NM_014786.3	NP_055601.2	Q96PE2	ARHGH_HUMAN	Rho guanine nucleotide exchange factor (GEF) 17	963	Pro-rich.				actin cytoskeleton organization|apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	Rho guanyl-nucleotide exchange factor activity			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(15)|ovary(2)|skin(2)	32						CCAGTGTGCCCGCCACATTTA	0.627000													37	337					0	0	1	0	0
KCNB2	9312	broad.mit.edu	37	8	73848509	73848509	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr8:73848509C>T	ENST00000523207.1	+	3	1507	c.919C>T	c.(919-921)Cgc>Tgc	p.R307C		NM_004770.2	NP_004761.2	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related subfamily, member 2	307					regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(20)|liver(2)|lung(31)|ovary(2)|pancreas(3)|prostate(2)|skin(8)|upper_aerodigestive_tract(4)|urinary_tract(1)	85	Breast(64;0.137)		Epithelial(68;0.105)			CCGAATCATGCGCATCCTCAG	0.512000													5	259					0	0	1	0	0
NTN5	126147	broad.mit.edu	37	19	49174003	49174003	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr19:49174003G>A	ENST00000270235.4	-	2	336	c.241C>T	c.(241-243)Cgc>Tgc	p.R81C	SEC1P_ENST00000430145.2_RNA	NM_145807.1	NP_665806.1	Q8WTR8	NET5_HUMAN	netrin 5	81						extracellular region				central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|pancreas(1)|prostate(1)	10						GTACAGAAGCGCAAGCTGACA	0.672000													20	110					0	0	1	0	0
CRCT1	54544	broad.mit.edu	37	1	152487990	152487990	+	Missense_Mutation	SNP	G	G	C			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr1:152487990G>C	ENST00000368790.3	+	2	204	c.131G>C	c.(130-132)aGg>aCg	p.R44T		NM_019060.2	NP_061933.1	Q9UGL9	CRCT1_HUMAN	cysteine-rich C-terminal 1	44	Cys-rich.									lung(1)|ovary(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			GGCTCCGGCAGGGGCTGCTGC	0.721000													4	75					0	0	1	0	0
POTEC	388468	broad.mit.edu	37	18	14542654	14542654	+	Silent	SNP	C	C	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr18:14542654C>A	ENST00000358970.5	-	1	491	c.492G>T	c.(490-492)acG>acT	p.T164T	POTEC_ENST00000389891.4_5'UTR	NM_001137671.1	NP_001131143.1	B2RU33	POTEC_HUMAN	POTE ankyrin domain family, member C	164								p.T164T(2)		NS(2)|breast(1)|endometrium(9)|kidney(13)|lung(14)|prostate(3)|skin(6)|soft_tissue(1)|urinary_tract(3)	52						TGTTCATGTCCGTGTCCCTGA	0.592000													5	539					1.23904e-05	1.31595e-05	1	1	0
NAB2	4665	broad.mit.edu	37	12	57485474	57485474	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr12:57485474C>T	ENST00000300131.3	+	2	1028	c.650C>T	c.(649-651)cCt>cTt	p.P217L	NAB2_ENST00000554718.1_3'UTR|NAB2_ENST00000357680.4_Missense_Mutation_p.P217L|NAB2_ENST00000342556.6_Missense_Mutation_p.P217L	NM_005967.3	NP_005958.1	Q15742	NAB2_HUMAN	NGFI-A binding protein 2 (EGR1 binding protein 2)	217					cell proliferation|negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	transcription corepressor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	20						GGAGGAGTCCCTGAGGGGACT	0.682000													22	215					0	0	1	0	0
HLCS	3141	broad.mit.edu	37	21	38308856	38308856	+	Missense_Mutation	SNP	G	G	A	rs139902499		TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr21:38308856G>A	ENST00000399120.1	-	5	2119	c.889C>T	c.(889-891)Cgg>Tgg	p.R297W	HLCS_ENST00000336648.3_Missense_Mutation_p.R297W	NM_001242784.1	NP_001229713.1	P50747	BPL1_HUMAN	holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)	297					cell proliferation|histone biotinylation|response to biotin	chromatin|cytosol|mitochondrion|nuclear lamina|nuclear matrix	ATP binding|biotin binding|biotin-[acetyl-CoA-carboxylase] ligase activity|biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity|biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity|biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity|enzyme binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|liver(1)|lung(8)|ovary(2)|upper_aerodigestive_tract(1)	24		Myeloproliferative disorder(46;0.0422)			Biotin(DB00121)	GGGCTGAGCCGGACGGGGCCT	0.592000													5	422					0	0	1	0	0
D86994.2	0	broad.mit.edu	37	22	23006961	23006961	+	RNA	SNP	C	C	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr22:23006961C>T	ENST00000385099.1	+	0	64																											GGCTCTGCTCCTCCTCACCCT	0.627000													3	28					0	0	1	0	0
KIAA0232	9778	broad.mit.edu	37	4	6865606	6865606	+	Missense_Mutation	SNP	G	G	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr4:6865606G>T	ENST00000307659.5	+	7	3952	c.3497G>T	c.(3496-3498)gGa>gTa	p.G1166V	KIAA0232_ENST00000425103.1_Missense_Mutation_p.G1166V	NM_014743.2	NP_055558.2	Q92628	K0232_HUMAN	KIAA0232	1166							ATP binding			breast(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(10)|lung(12)|ovary(2)|prostate(4)|skin(1)|urinary_tract(1)	41						CATTACTATGGAAAATCAGAG	0.413000													31	220					1.74807e-11	1.92288e-11	1	1	0
NDUFAF2	91942	broad.mit.edu	37	5	60241050	60241050	+	Translation_Start_Site	SNP	G	G	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr5:60241050G>A	ENST00000296597.5	+	0	95				NDUFAF2_ENST00000511107.1_De_novo_Start_OutOfFrame	NM_174889.4	NP_777549.1	Q8N183	MIMIT_HUMAN	NADH dehydrogenase (ubiquinone) complex I, assembly factor 2							membrane|mitochondrion	electron carrier activity|NADH dehydrogenase (ubiquinone) activity			central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(1)|ovary(1)	6		Lung NSC(810;3.36e-05)|Prostate(74;0.0225)|Ovarian(174;0.17)|Breast(144;0.237)				TGCGGGTCCCGCTGCTGGCAG	0.632000													6	79					0	0	1	0	0
RPL23AP53	0	broad.mit.edu	37	8	163215	163215	+	RNA	SNP	G	G	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr8:163215G>A	ENST00000606975.1	-	0	706																											AGATACACATGTATTTAGAGT	0.323000													8	148					0	0	1	0	0
MST1	4485	broad.mit.edu	37	3	49724837	49724837	+	Missense_Mutation	SNP	G	G	A	rs41291712		TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr3:49724837G>A	ENST00000449682.2	-	4	791	c.430C>T	c.(430-432)Ccc>Tcc	p.P144S	MST1_ENST00000383728.3_Missense_Mutation_p.P69S|MST1_ENST00000545762.1_Intron|MST1_ENST00000494828.2_5'UTR	NM_020998.3	NP_066278.3	P26927	HGFL_HUMAN	macrophage stimulating 1 (hepatocyte growth factor-like)	130	Kringle 1.				proteolysis	extracellular region	serine-type endopeptidase activity			NS(4)|breast(1)|central_nervous_system(1)|endometrium(10)|kidney(1)|large_intestine(1)|lung(9)|prostate(2)|skin(9)|stomach(1)|urinary_tract(2)	41				BRCA - Breast invasive adenocarcinoma(193;4.47e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		GCCTGGCAGGGCAGGCCACCC	0.587000													5	330					0	0	1	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22661478	22661478	+	RNA	SNP	T	T	G			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr22:22661478T>G	ENST00000426066.1	+	0	368					NR_027293.1																						CAGATGCGTCTGAAGAAACAT	0.488000													7	211					0	0	1	0	0
PCSK5	5125	broad.mit.edu	37	9	78790192	78790192	+	Missense_Mutation	SNP	C	C	G			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr9:78790192C>G	ENST00000376767.3	+	14	2559	c.2047C>G	c.(2047-2049)Cga>Gga	p.R683G	PCSK5_ENST00000376752.4_Intron|PCSK5_ENST00000545128.1_Intron			Q92824	PCSK5_HUMAN	proprotein convertase subtilisin/kexin type 5	0	CRM (Cys-rich motif).				anterior/posterior pattern formation|cell-cell signaling|cytokine biosynthetic process|embryo implantation|embryonic digestive tract development|embryonic skeletal system development|heart development|kidney development|limb morphogenesis|nerve growth factor processing|nerve growth factor receptor signaling pathway|peptide biosynthetic process|renin secretion into blood stream|respiratory tube development|signal peptide processing|viral assembly, maturation, egress, and release	extracellular space|Golgi lumen|stored secretory granule	peptide binding|serine-type endopeptidase activity			NS(1)|breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(7)|liver(2)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	55						ggaatggaatcgaatcgaatc	0.373000													3	29					0	0	1	0	0
MAGEE1	57692	broad.mit.edu	37	X	75648564	75648564	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chrX:75648564C>T	ENST00000361470.2	+	1	519	c.241C>T	c.(241-243)Ccg>Tcg	p.P81S		NM_020932.2	NP_065983.1	Q9HCI5	MAGE1_HUMAN	melanoma antigen family E, 1	81						dendrite|nucleus|perinuclear region of cytoplasm|postsynaptic membrane				breast(3)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(12)|lung(20)|ovary(1)|pancreas(1)|skin(3)|urinary_tract(1)	51						CACCTTTGTGCCGCCCACCAT	0.682000													3	48					0	0	1	0	0
BAI1	575	broad.mit.edu	37	8	143614731	143614731	+	Silent	SNP	C	C	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr8:143614731C>T	ENST00000517894.1	+	25	4368	c.3474C>T	c.(3472-3474)acC>acT	p.T1158T	BAI1_ENST00000323289.5_Silent_p.T1158T			O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	1158					axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|large_intestine(2)|lung(28)|ovary(4)|pancreas(1)|prostate(7)	57	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					TCGCCGTCACCGACCGCCGCT	0.657000													7	49					0	0	1	0	0
TMEM252	169693	broad.mit.edu	37	9	71155605	71155605	+	Silent	SNP	C	C	T	rs147451213		TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr9:71155605C>T	ENST00000377311.3	-	1	178	c.126G>A	c.(124-126)gcG>gcA	p.A42A		NM_153237.1	NP_694969.1			transmembrane protein 252																		GCAAATAGGCCGCAATCAGGC	0.532000													18	131					0	0	1	0	0
PDE4DIP	9659	broad.mit.edu	37	1	144859863	144859863	+	Missense_Mutation	SNP	T	T	G			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr1:144859863T>G	ENST00000369359.4	-	41	6667	c.6629A>C	c.(6628-6630)cAg>cCg	p.Q2210P	RP4-791M13.4_ENST00000532137.1_RNA|PDE4DIP_ENST00000369356.4_Missense_Mutation_p.Q2074P|PDE4DIP_ENST00000369354.3_Missense_Mutation_p.Q2074P|PDE4DIP_ENST00000524974.1_5'UTR|PDE4DIP_ENST00000313382.9_Missense_Mutation_p.Q1968P|PDE4DIP_ENST00000530740.1_Missense_Mutation_p.Q2159P			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	2074					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		CTCCAGCTGCTGTTGCAGCTG	0.597000			T	PDGFRB	MPD								20	422					0	0	1	0	0
RTKN2	219790	broad.mit.edu	37	10	63957932	63957932	+	Missense_Mutation	SNP	G	G	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr10:63957932G>T	ENST00000373789.3	-	12	1661	c.1565C>A	c.(1564-1566)aCa>aAa	p.T522K	RTKN2_ENST00000315289.2_Intron|RTKN2_ENST00000395265.1_Intron	NM_145307.2	NP_660350.2	Q8IZC4	RTKN2_HUMAN	rhotekin 2	522					signal transduction	intracellular				endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(3)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	Prostate(12;0.0297)|all_hematologic(501;0.215)					CAATTGATCTGTGTTACTCTG	0.398000													67	571					2.18329e-32	2.56661e-32	1	1	0
NAB2	4665	broad.mit.edu	37	12	57485473	57485473	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr12:57485473C>T	ENST00000300131.3	+	2	1027	c.649C>T	c.(649-651)Cct>Tct	p.P217S	NAB2_ENST00000554718.1_3'UTR|NAB2_ENST00000357680.4_Missense_Mutation_p.P217S|NAB2_ENST00000342556.6_Missense_Mutation_p.P217S	NM_005967.3	NP_005958.1	Q15742	NAB2_HUMAN	NGFI-A binding protein 2 (EGR1 binding protein 2)	217					cell proliferation|negative regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	nucleus	transcription corepressor activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(5)|ovary(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(1)	20						GGGAGGAGTCCCTGAGGGGAC	0.682000													21	214					0	0	1	0	0
ACTN3	89	broad.mit.edu	37	11	66318750	66318750	+	RNA	SNP	G	G	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr11:66318750G>A	ENST00000513398.1	+	0	285				ACTN3_ENST00000502692.1_RNA	NM_001104.2	NP_001095.1	Q08043	ACTN3_HUMAN	actinin, alpha 3 (gene/pseudogene)						focal adhesion assembly|muscle filament sliding|regulation of apoptosis	actin filament|cytosol|focal adhesion|pseudopodium	actin binding|calcium ion binding|integrin binding|protein homodimerization activity|structural constituent of muscle			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(2)	10						CGCAAGGCAGGCACCCAGATC	0.562000													6	51					0	0	1	0	0
TMED1	11018	broad.mit.edu	37	19	10945733	10945733	+	Silent	SNP	G	G	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr19:10945733G>T	ENST00000214869.2	-	3	440	c.342C>A	c.(340-342)atC>atA	p.I114I	TMED1_ENST00000591695.1_Intron|TMED1_ENST00000588289.1_5'UTR	NM_006858.2	NP_006849.1	Q13445	TMED1_HUMAN	transmembrane emp24 protein transport domain containing 1	114	GOLD.				cell-cell signaling|signal transduction|transport	integral to membrane|plasma membrane	receptor binding			breast(1)|central_nervous_system(2)|lung(2)|ovary(3)|prostate(1)|skin(1)	10						GCTTCTCGGAGATGGTGCTGA	0.587000													48	376					1.76056e-25	2.05398e-25	1	1	0
CRCT1	54544	broad.mit.edu	37	1	152487987	152487987	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr1:152487987G>A	ENST00000368790.3	+	2	201	c.128G>A	c.(127-129)gGc>gAc	p.G43D		NM_019060.2	NP_061933.1	Q9UGL9	CRCT1_HUMAN	cysteine-rich C-terminal 1	43	Cys-rich.									lung(1)|ovary(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGCGGCTCCGGCAGGGGCTGC	0.726000													4	77					0	0	1	0	0
DCAF12L1	139170	broad.mit.edu	37	X	125686253	125686253	+	Silent	SNP	G	G	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chrX:125686253G>A	ENST00000371126.1	-	1	581	c.339C>T	c.(337-339)tgC>tgT	p.C113C		NM_178470.4	NP_848565.2	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	113										breast(1)|central_nervous_system(3)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(6)|lung(39)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	68						ACTTGGTGCCGCACACCACCT	0.637000													4	182					0	0	1	0	0
DNAH11	8701	broad.mit.edu	37	7	21751430	21751430	+	Missense_Mutation	SNP	C	C	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr7:21751430C>A	ENST00000328843.6	+	43	6987	c.6956C>A	c.(6955-6957)tCc>tAc	p.S2319Y	DNAH11_ENST00000409508.3_Missense_Mutation_p.S2312Y			Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2319	AAA 2 (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(1)|autonomic_ganglia(1)|breast(13)|central_nervous_system(3)|cervix(4)|endometrium(18)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(50)|lung(101)|ovary(10)|pancreas(4)|prostate(7)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	230						GCCACTGTTTCCAGAGCTGGT	0.448000									Kartagener syndrome				25	139					3.6726e-16	4.15868e-16	1	1	0
C17orf70	80233	broad.mit.edu	37	17	79514425	79514425	+	Silent	SNP	G	G	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr17:79514425G>A	ENST00000537152.1	-	5	1755	c.1230C>T	c.(1228-1230)tcC>tcT	p.S410S	C17orf70_ENST00000425898.2_Silent_p.S210S|C17orf70_ENST00000327787.8_Silent_p.S561S	NM_025161.5	NP_079437.5	Q0VG06	FP100_HUMAN	chromosome 17 open reading frame 70	561					DNA repair	cytoplasm|intermediate filament cytoskeleton|nucleoplasm	DNA binding			breast(1)|central_nervous_system(1)|endometrium(1)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	19	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0371)			AGGTGATGGCGGAGCAGGCCG	0.677000													6	410					0	0	1	0	0
TYSND1	219743	broad.mit.edu	37	10	71903618	71903618	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr10:71903618G>A	ENST00000287078.6	-	2	1276	c.1277C>T	c.(1276-1278)cCc>cTc	p.P426L	TYSND1_ENST00000335494.5_Intron|TYSND1_ENST00000494143.1_5'UTR	NM_173555.2	NP_775826.2	Q2T9J0	TYSD1_HUMAN	trypsin domain containing 1	426	Serine protease.				proteolysis	peroxisome	serine-type endopeptidase activity			endometrium(2)|large_intestine(2)|liver(1)|lung(3)|prostate(1)	9						GTGCTCAGCGGGCACAGGGAT	0.587000													8	128					0	0	1	0	0
MAML3	55534	broad.mit.edu	37	4	140811108	140811108	+	Silent	SNP	C	C	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr4:140811108C>T	ENST00000509479.2	-	2	2338	c.1482G>A	c.(1480-1482)caG>caA	p.Q494Q	MAML3_ENST00000327122.5_Silent_p.Q338Q|MAML3_ENST00000398940.1_Silent_p.Q33Q	NM_018717.4	NP_061187.2	Q96JK9	MAML3_HUMAN	mastermind-like 3 (Drosophila)	494	Gln-rich.				Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity			breast(1)|endometrium(7)|kidney(2)|large_intestine(1)|lung(9)|ovary(1)|prostate(2)|urinary_tract(2)	25	all_hematologic(180;0.162)					gctgctgctgctgctgctgct	0.537000													5	145					0	0	1	0	0
SYNPO2L	79933	broad.mit.edu	37	10	75406952	75406952	+	Missense_Mutation	SNP	A	A	G			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr10:75406952A>G	ENST00000394810.2	-	4	2607	c.2458T>C	c.(2458-2460)Ttt>Ctt	p.F820L	SYNPO2L_ENST00000372872.4_Intron|SYNPO2L_ENST00000372873.4_Missense_Mutation_p.F596L	NM_001114133.1	NP_001107605.1	Q9H987	SYP2L_HUMAN	synaptopodin 2-like	820	Pro-rich.					cytoplasm|cytoskeleton	actin binding			breast(2)|endometrium(3)|kidney(3)|large_intestine(5)|lung(6)|ovary(1)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	26	Prostate(51;0.0112)					TGGGGGAAAAAGGGAGAGAGC	0.577000													6	556					0	0	1	0	0
CD59	966	broad.mit.edu	37	11	33731808	33731808	+	Missense_Mutation	SNP	A	A	C			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr11:33731808A>C	ENST00000395850.3	-	4	326	c.251T>G	c.(250-252)cTa>cGa	p.L84R	CD59_ENST00000533403.1_3'UTR|CD59_ENST00000527577.1_Missense_Mutation_p.L84R|CD59_ENST00000415002.2_Missense_Mutation_p.L84R|CD59_ENST00000528700.1_Missense_Mutation_p.L84R|CD59_ENST00000437761.2_Missense_Mutation_p.L84R|CD59_ENST00000426650.2_Missense_Mutation_p.L84R|CD59_ENST00000534312.1_Missense_Mutation_p.L84R|CD59_ENST00000445143.2_Missense_Mutation_p.L84R|CD59_ENST00000351554.3_Missense_Mutation_p.L84R	NM_000611.5|NM_001127225.1|NM_001127226.1|NM_001127227.1|NM_203329.2|NM_203330.2|NM_203331.2	NP_000602.1|NP_001120697.1|NP_001120698.1|NP_001120699.1|NP_976074.1|NP_976075.1|NP_976076.1	P13987	CD59_HUMAN	CD59 molecule, complement regulatory protein	84	UPAR/Ly6.				blood coagulation|cell surface receptor linked signaling pathway	anchored to external side of plasma membrane|extracellular region|membrane fraction				endometrium(1)|lung(2)	3						GTAGTACGTTAGCTCATTTTC	0.443000													24	212					0	0	1	0	0
DNM1P47	0	broad.mit.edu	37	15	102294661	102294661	+	RNA	SNP	G	G	C			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr15:102294661G>C	ENST00000561463.1	+	0	2707																											TGTCCAACCTGCACTCGCTTG	0.592000													23	63					0	0	1	0	0
AMOT	154796	broad.mit.edu	37	X	112058796	112058796	+	Silent	SNP	C	C	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chrX:112058796C>T	ENST00000371959.3	-	2	1181	c.1182G>A	c.(1180-1182)caG>caA	p.Q394Q	AMOT_ENST00000371962.1_Silent_p.Q162Q|AMOT_ENST00000524145.1_Silent_p.Q394Q|AMOT_ENST00000371958.1_Silent_p.Q162Q|AMOT_ENST00000304758.1_5'UTR	NM_001113490.1	NP_001106962.1	Q4VCS5	AMOT_HUMAN	angiomotin	394					actin cytoskeleton organization|cell-cell junction assembly|negative regulation of angiogenesis|negative regulation of vascular permeability|positive regulation of blood vessel endothelial cell migration|positive regulation of cell size|positive regulation of stress fiber assembly|regulation of cell migration	actin filament|cell surface|cytoplasm|endocytic vesicle|external side of plasma membrane|integral to membrane|lamellipodium|ruffle|stress fiber|tight junction	angiostatin binding|protein binding|receptor activity	p.Q394Q(1)		breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	43						gctgctgctgctgttgttggt	0.582000													6	98					0	0	1	0	0
CRCT1	54544	broad.mit.edu	37	1	152487989	152487989	+	Missense_Mutation	SNP	A	A	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr1:152487989A>T	ENST00000368790.3	+	2	203	c.130A>T	c.(130-132)Agg>Tgg	p.R44W		NM_019060.2	NP_061933.1	Q9UGL9	CRCT1_HUMAN	cysteine-rich C-terminal 1	44	Cys-rich.									lung(1)|ovary(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			CGGCTCCGGCAGGGGCTGCTG	0.721000													4	76					0	0	1	0	0
CLK3	1198	broad.mit.edu	37	15	74922153	74922153	+	Missense_Mutation	SNP	C	C	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr15:74922153C>A	ENST00000395066.3	+	13	2307	c.1846C>A	c.(1846-1848)Ctg>Atg	p.L616M	CLK3_ENST00000345005.4_Missense_Mutation_p.L468M|CLK3_ENST00000352989.5_Missense_Mutation_p.L445M|CLK3_ENST00000348245.3_3'UTR	NM_001130028.1	NP_001123500.1	P49761	CLK3_HUMAN	CDC-like kinase 3	616	Protein kinase.					acrosomal vesicle|nucleus	ATP binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			breast(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(2)|stomach(2)|urinary_tract(1)	15						CGAGGCCCTGCTGCACCCCTT	0.607000													15	78					1.52009e-12	1.68413e-12	1	1	0
TMCC1	23023	broad.mit.edu	37	3	129370592	129370592	+	Missense_Mutation	SNP	T	T	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr3:129370592T>A	ENST00000393238.3	-	6	2034	c.1694A>T	c.(1693-1695)cAg>cTg	p.Q565L	TMCC1_ENST00000329333.5_Missense_Mutation_p.Q386L|TMCC1_ENST00000426664.2_Missense_Mutation_p.Q451L|TMCC1_ENST00000432054.2_Missense_Mutation_p.Q241L	NM_001017395.3	NP_001017395.2	O94876	TMCC1_HUMAN	transmembrane and coiled-coil domain family 1	565						integral to membrane			PLXND1/TMCC1(4)	breast(1)|endometrium(3)|large_intestine(8)|lung(12)|skin(1)	25						CTGCTGCTGCTGCAGCTCCAT	0.572000													4	282					0	0	1	0	0
MAGEC1	9947	broad.mit.edu	37	X	140994960	140994960	+	Silent	SNP	G	G	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chrX:140994960G>A	ENST00000285879.4	+	4	2056	c.1770G>A	c.(1768-1770)ctG>ctA	p.L590L	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	590							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					AGGACTCCCTGTCTCCTCACT	0.567000										HNSCC(15;0.026)			7	953					0	0	1	0	0
JAK3	3718	broad.mit.edu	37	19	17943491	17943491	+	Silent	SNP	G	G	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr19:17943491G>A	ENST00000458235.1	-	19	2616	c.2517C>T	c.(2515-2517)tgC>tgT	p.C839C	JAK3_ENST00000534444.1_Silent_p.C839C|JAK3_ENST00000527670.1_Silent_p.C839C	NM_000215.3	NP_000206.2	P52333	JAK3_HUMAN	Janus kinase 3	839	Protein kinase 2.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			breast(5)|endometrium(4)|haematopoietic_and_lymphoid_tissue(85)|kidney(4)|large_intestine(11)|lung(22)|ovary(3)|prostate(5)|skin(1)|stomach(2)|upper_aerodigestive_tract(5)	147						GGTCATAGCGGCACAGCTCCA	0.647000		2	Mis		"""acute megakaryocytic leukemia, ETP ALL"""								6	547					0	0	1	0	0
OR1M1	125963	broad.mit.edu	37	19	9204125	9204125	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr19:9204125G>A	ENST00000429566.3	+	1	271	c.205G>A	c.(205-207)Gtt>Att	p.V69I		NM_001004456.1	NP_001004456.1	Q8NGA1	OR1M1_HUMAN	olfactory receptor, family 1, subfamily M, member 1	69					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.V69I(2)		breast(1)|endometrium(4)|large_intestine(3)|lung(17)|ovary(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	32						CCTGTCCCTGGTTGATTTCTG	0.557000													8	293					0	0	1	0	0
KCNH6	81033	broad.mit.edu	37	17	61607501	61607501	+	Silent	SNP	C	C	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr17:61607501C>T	ENST00000583023.1	+	3	368	c.357C>T	c.(355-357)gaC>gaT	p.D119D	KCNH6_ENST00000581784.1_Silent_p.D119D|KCNH6_ENST00000580652.1_Silent_p.D119D|KCNH6_ENST00000456941.2_Silent_p.D119D|KCNH6_ENST00000314672.5_Silent_p.D119D	NM_030779.2	NP_110406.1	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H (eag-related), member 6	119	PAC.				regulation of transcription, DNA-dependent|signal transduction					breast(2)|central_nervous_system(2)|endometrium(9)|kidney(4)|large_intestine(6)|lung(20)|ovary(2)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(2)	54					Ibutilide(DB00308)	AGAACGAGGACGGGGCTGTCA	0.632000													23	274					0	0	1	0	0
COL18A1	80781	broad.mit.edu	37	21	46925285	46925285	+	Silent	SNP	C	C	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr21:46925285C>T	ENST00000359759.4	+	35	4293	c.4272C>T	c.(4270-4272)ccC>ccT	p.P1424P	SLC19A1_ENST00000567670.1_Intron|COL18A1_ENST00000400337.2_Silent_p.P1009P|COL18A1_ENST00000355480.5_Silent_p.P1189P			P39060	COIA1_HUMAN	collagen, type XVIII, alpha 1	1424	Nonhelical region 10 (NC10).				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(4)|lung(8)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	25				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		TCAGCGTTCCCGGCCCTCCGG	0.701000													6	86					0	0	1	0	0
D86994.2	0	broad.mit.edu	37	22	23006960	23006960	+	RNA	SNP	C	C	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr22:23006960C>A	ENST00000385099.1	+	0	63																											GGGCTCTGCTCCTCCTCACCC	0.627000													3	26					0.004672	0.00473347	1	1	0
IGHV4-31	0	broad.mit.edu	37	14	106805378	106805378	+	RNA	SNP	G	G	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr14:106805378G>T	ENST00000438142.2	-	0	256																											GCCCTTCCCTGGGTGCTGGCG	0.552000													48	378					8.04919e-23	9.25056e-23	1	1	0
KLHL26	55295	broad.mit.edu	37	19	18779702	18779702	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr19:18779702G>A	ENST00000300976.4	+	3	1585	c.1495G>A	c.(1495-1497)Gtg>Atg	p.V499M	KLHL26_ENST00000599006.1_Intron	NM_018316.1	NP_060786.1	Q53HC5	KLH26_HUMAN	kelch-like family member 26	499								p.V499M(1)		breast(1)|central_nervous_system(1)|kidney(1)|lung(10)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	17						CGAACCCCGCGTGCTACACGC	0.667000													33	282					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414340	20414340	+	Silent	SNP	G	G	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr9:20414340G>A	ENST00000380338.4	-	5	790	c.504C>T	c.(502-504)agC>agT	p.S168S	MLLT3_ENST00000429426.2_Silent_p.S165S|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	168	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S168S(5)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.537000			T	MLL	ALL								13	229					0	0	1	0	0
DLX5	1749	broad.mit.edu	37	7	96650202	96650202	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr7:96650202G>A	ENST00000222598.4	-	3	1189	c.716C>T	c.(715-717)gCc>gTc	p.A239V	DLX5_ENST00000493764.1_5'UTR	NM_005221.5	NP_005212.1	P56178	DLX5_HUMAN	distal-less homeobox 5	239					cell proliferation|endochondral ossification|osteoblast differentiation|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(9)|ovary(1)|prostate(1)	20	all_cancers(62;9.56e-09)|all_epithelial(64;7.38e-09)|Esophageal squamous(72;0.0125)|all_lung(186;0.0855)|Lung NSC(181;0.0858)					CGGAGGGTGGGCATGAGGGTG	0.642000													5	265					0	0	1	0	0
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr1:145367739A>G	ENST00000342960.5	+	83	10370	c.10335A>G	c.(10333-10335)aaA>aaG	p.K3445K	NBPF10_ENST00000369339.2_Intron|NBPF10_ENST00000369338.1_Intron	NM_001039703.4	NP_001034792.4	A6NDV3	A6NDV3_HUMAN	neuroblastoma breakpoint family, member 10	3445								p.K3445K(4)		NS(3)|breast(1)|central_nervous_system(3)|endometrium(12)|kidney(23)|lung(15)|ovary(1)|prostate(7)|skin(6)|urinary_tract(2)	73	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.413000													4	296					0	0	1	0	0
MDN1	23195	broad.mit.edu	37	6	90482330	90482330	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr6:90482330C>T	ENST00000369393.3	-	14	2160	c.2045G>A	c.(2044-2046)gGc>gAc	p.G682D	MDN1_ENST00000428876.1_Missense_Mutation_p.G682D			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	682					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		AGAGGTTTTGCCAGTCCCGGT	0.493000													7	436					0	0	1	0	0
KRAS	3845	broad.mit.edu	37	12	25398284	25398284	+	Missense_Mutation	SNP	C	C	A	rs121913529		TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr12:25398284C>A	ENST00000311936.3	-	2	226	c.35G>T	c.(34-36)gGt>gTt	p.G12V	KRAS_ENST00000256078.4_Missense_Mutation_p.G12V|KRAS_ENST00000557334.1_Missense_Mutation_p.G12V|KRAS_ENST00000556131.1_Missense_Mutation_p.G12V	NM_004985.3	NP_004976.2	P01116	RASK_HUMAN	Kirsten rat sarcoma viral oncogene homolog	12			G -> A (in a colorectal cancer sample; somatic mutation).|G -> C (in lung carcinoma; somatic mutation).|G -> D (in pancreatic carcinoma, GASC and lung carcinoma; somatic mutation).|G -> R (in lung cancer and bladder cancer; somatic mutation).|G -> S (in lung carcinoma and GASC; somatic mutation).|G -> V (in lung carcinoma, pancreatic carcinoma, colon cancer and GASC; somatic mutation).		activation of MAPKK activity|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding	p.G12D(8562)|p.G12V(5775)|p.G12A(1407)|p.G12F(46)|p.G12L(8)|p.G12I(4)|p.G12E(3)|p.G12W(3)|p.G12Y(2)|p.G12fs*3(1)|p.G12C(1)|p.G12N(1)	UBE2L3/KRAS(2)	NS(6)|adrenal_gland(1)|autonomic_ganglia(3)|biliary_tract(532)|bone(2)|breast(32)|central_nervous_system(14)|cervix(50)|endometrium(411)|eye(4)|gastrointestinal_tract_(site_indeterminate)(7)|genital_tract(1)|haematopoietic_and_lymphoid_tissue(385)|kidney(8)|large_intestine(15267)|liver(29)|lung(3407)|oesophagus(16)|ovary(612)|pancreas(3739)|penis(1)|peritoneum(6)|prostate(96)|salivary_gland(6)|skin(45)|small_intestine(68)|soft_tissue(88)|stomach(207)|testis(17)|thymus(5)|thyroid(159)|upper_aerodigestive_tract(68)|urinary_tract(57)	25349	all_cancers(2;1e-35)|all_epithelial(2;1.97e-38)|all_lung(3;2.1e-23)|Lung NSC(3;1.16e-22)|Acute lymphoblastic leukemia(6;0.00231)|all_hematologic(7;0.00259)|Melanoma(3;0.0301)|Colorectal(261;0.11)|Ovarian(17;0.12)		OV - Ovarian serous cystadenocarcinoma(3;1.23e-21)|Epithelial(3;1.31e-20)|all cancers(3;5.45e-18)|STAD - Stomach adenocarcinoma(2;2.68e-05)			GCCTACGCCACCAGCTCCAAC	0.348000	G12A(KMS28BM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(KPNSI9S_AUTONOMIC_GANGLIA)|G12A(MM1S_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(NCIH1573_LUNG)|G12A(NCIH2009_LUNG)|G12A(RERFLCAD1_LUNG)|G12A(RPMI8226_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12A(SW1116_LARGE_INTESTINE)|G12D(AGS_STOMACH)|G12D(ASPC1_PANCREAS)|G12D(COLO678_LARGE_INTESTINE)|G12D(HEC1A_ENDOMETRIUM)|G12D(HEC50B_ENDOMETRIUM)|G12D(HEYA8_OVARY)|G12D(HPAC_PANCREAS)|G12D(HPAFII_PANCREAS)|G12D(KARPAS620_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|G12D(KP4_PANCREAS)|G12D(L33_PANCREAS)|G12D(LS180_LARGE_INTESTINE)|G12D(LS513_LARGE_INTESTINE)|G12D(MCAS_OVARY)|G12D(PANC0203_PANCREAS)|G12D(PANC0403_PANCREAS)|G12D(PANC0504_PANCREAS)|G12D(PANC0813_PANCREAS)|G12D(PANC1_PANCREAS)|G12D(PK1_PANCREAS)|G12D(PK59_PANCREAS)|G12D(SKLU1_LUNG)|G12D(SNUC2A_LARGE_INTESTINE)|G12D(SU8686_PANCREAS)|G12D(SUIT2_PANCREAS)|G12D(SW1990_PANCREAS)|G12V(A498_KIDNEY)|G12V(CAPAN2_PANCREAS)|G12V(CFPAC1_PANCREAS)|G12V(COLO668_LUNG)|G12V(CORL23_LUNG)|G12V(DANG_PANCREAS)|G12V(HCC56_LARGE_INTESTINE)|G12V(HUPT4_PANCREAS)|G12V(KP3_PANCREAS)|G12V(LCLC97TM1_LUNG)|G12V(NCIH2444_LUNG)|G12V(NCIH441_LUNG)|G12V(NCIH727_LUNG)|G12V(PANC0327_PANCREAS)|G12V(PATU8902_PANCREAS)|G12V(PATU8988S_PANCREAS)|G12V(QGP1_PANCREAS)|G12V(RCM1_LARGE_INTESTINE)|G12V(RERFLCAD2_LUNG)|G12V(RKN_OVARY)|G12V(SH10TC_STOMACH)|G12V(SHP77_LUNG)|G12V(SNGM_ENDOMETRIUM)|G12V(SW403_LARGE_INTESTINE)|G12V(SW480_LARGE_INTESTINE)|G12V(SW620_LARGE_INTESTINE)|G12V(SW900_LUNG)|G12V(YAPC_PANCREAS)	119	Mis		"""pancreatic, colorectal, lung, thyroid, AML, others"""				Noonan syndrome;Cardiofaciocutaneous syndrome	TSP Lung(1;<1E-08)|Multiple Myeloma(2;<1E-6)			10	84					0.000673444	0.000696043	1	1	0
DNM1P47	0	broad.mit.edu	37	15	102292953	102292953	+	RNA	SNP	T	T	C			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr15:102292953T>C	ENST00000561463.1	+	0	999																											GGCACAGCGGTGCGACGAGAT	0.587000													4	84					0	0	1	0	0
HID1	283987	broad.mit.edu	37	17	72955992	72955992	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr17:72955992C>T	ENST00000425042.2	-	8	1069	c.992G>A	c.(991-993)cGc>cAc	p.R331H		NM_030630.2	NP_085133.1			HID1 domain containing																		ACGATGGATGCGGGACAGGTA	0.627000													6	560					0	0	1	0	0
NCOA3	8202	broad.mit.edu	37	20	46279860	46279860	+	Silent	SNP	G	G	A	rs151060280	byFrequency	TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr20:46279860G>A	ENST00000372004.3	+	20	3990	c.3774G>A	c.(3772-3774)caG>caA	p.Q1258Q	NCOA3_ENST00000371997.3_Silent_p.Q1253Q|NCOA3_ENST00000371998.3_Silent_p.Q1262Q|NCOA3_ENST00000341724.6_Silent_p.Q1188Q	NM_001174087.1|NM_001174088.1|NM_006534.3|NM_181659.2	NP_001167558.1|NP_001167559.1|NP_006525.2|NP_858045.1	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3	1262	Acetyltransferase.|Poly-Gln.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding	p.Q1262Q(1)		breast(3)|endometrium(3)|kidney(4)|large_intestine(12)|lung(19)|ovary(4)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	52						agcagcagcagcagcaacagc	0.567000													5	209					0	0	1	0	0
ARHGEF7	8874	broad.mit.edu	37	13	111862267	111862267	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr13:111862267G>A	ENST00000375741.2	+	5	699	c.449G>A	c.(448-450)cGc>cAc	p.R150H	ARHGEF7_ENST00000426073.2_5'UTR|ARHGEF7_ENST00000544132.1_Intron|ARHGEF7_ENST00000370623.3_Intron|ARHGEF7_ENST00000375723.1_5'UTR|ARHGEF7_ENST00000218789.5_5'UTR|ARHGEF7_ENST00000375737.5_Missense_Mutation_p.R47H|ARHGEF7_ENST00000375736.4_5'UTR|ARHGEF7_ENST00000375739.2_Missense_Mutation_p.R100H|ARHGEF7_ENST00000317133.5_Missense_Mutation_p.R129H	NM_001113511.1|NM_145735.2	NP_001106983.1|NP_663788.1	Q14155	ARHG7_HUMAN	Rho guanine nucleotide exchange factor (GEF) 7	150					apoptosis|epidermal growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	protein binding|Rho guanyl-nucleotide exchange factor activity			breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(9)|lung(16)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|soft_tissue(1)	41	all_lung(23;3.96e-05)|Lung NSC(43;0.00156)|Lung SC(71;0.0753)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.188)			TCGTCTCACCGCATAAAGTCT	0.517000													7	777					0	0	1	0	0
LINC00969	0	broad.mit.edu	37	3	195400728	195400728	+	RNA	SNP	A	A	G	rs12107841	by1000genomes	TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr3:195400728A>G	ENST00000445430.1	+	0	1324																											GATTGTGCCCAGCCTGTACGC	0.587000													19	204					0	0	1	0	0
CAMK2B	816	broad.mit.edu	37	7	44282246	44282246	+	Silent	SNP	G	G	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr7:44282246G>T	ENST00000395749.2	-	9	685	c.609C>A	c.(607-609)atC>atA	p.I203I	CAMK2B_ENST00000258682.6_Silent_p.I203I|CAMK2B_ENST00000440254.2_Silent_p.I203I|CAMK2B_ENST00000347193.4_Silent_p.I203I|CAMK2B_ENST00000358707.3_Silent_p.I203I|CAMK2B_ENST00000346990.4_Silent_p.I203I|CAMK2B_ENST00000502837.2_Silent_p.I74I|CAMK2B_ENST00000395747.2_Silent_p.I203I|CAMK2B_ENST00000353625.4_Silent_p.I203I|CAMK2B_ENST00000350811.3_Silent_p.I203I|CAMK2B_ENST00000457475.1_Silent_p.I203I	NM_001220.4	NP_001211.3	Q13554	KCC2B_HUMAN	calcium/calmodulin-dependent protein kinase II beta	203	Protein kinase.				interferon-gamma-mediated signaling pathway|synaptic transmission	cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)	18						GGATGTACAGGATCACCCCTG	0.627000													5	64					0.014758	0.014758	1	1	0
ZNF341	84905	broad.mit.edu	37	20	32336800	32336800	+	Missense_Mutation	SNP	C	C	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr20:32336800C>A	ENST00000375200.1	+	4	776	c.411C>A	c.(409-411)agC>agA	p.S137R	ZNF341_ENST00000342427.2_Missense_Mutation_p.S137R			Q9BYN7	ZN341_HUMAN	zinc finger protein 341	137					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(4)|large_intestine(3)|lung(8)|ovary(2)|prostate(3)|skin(1)|urinary_tract(3)	31						TCTTGGTGAGCGATGATGTGC	0.582000													25	242					7.87624e-14	8.85359e-14	1	1	0
CADM1	23705	broad.mit.edu	37	11	115080343	115080343	+	Silent	SNP	G	G	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr11:115080343G>T	ENST00000537058.1	-	8	1049	c.1029C>A	c.(1027-1029)acC>acA	p.T343T	CADM1_ENST00000537140.1_Intron|CADM1_ENST00000542447.2_Intron|CADM1_ENST00000331581.6_Silent_p.T343T|CADM1_ENST00000536727.1_Intron|CADM1_ENST00000452722.2_Silent_p.T343T			Q9BY67	CADM1_HUMAN	cell adhesion molecule 1	343				PPTTIPPPTTTTTTTTTTTTTILTIIT -> TTATTEPAVH GLTQLPNSAEELDSEDLS (in Ref. 3; BAC11657).	adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding	p.T343T(5)		cervix(1)|endometrium(4)|kidney(4)|large_intestine(11)|lung(9)|ovary(2)|skin(1)	32	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		tggtggtggtggttgttgtgg	0.433000													7	223					0.00198382	0.00203672	1	1	0
OR2T3	343173	broad.mit.edu	37	1	248636948	248636948	+	Silent	SNP	G	G	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr1:248636948G>A	ENST00000359594.2	+	1	322	c.297G>A	c.(295-297)ccG>ccA	p.P99P		NM_001005495.1	NP_001005495.1	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T, member 3	99					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|endometrium(5)|lung(19)|ovary(1)|prostate(1)|skin(3)	31	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CCATTTCCCCGTCAGGCTGTG	0.547000													27	196					0	0	1	0	0
STRAP	11171	broad.mit.edu	37	12	16036495	16036495	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr12:16036495C>T	ENST00000419869.2	+	2	446	c.133C>T	c.(133-135)Cag>Tag	p.Q45*	STRAP_ENST00000538352.1_Intron|STRAP_ENST00000025399.6_Nonsense_Mutation_p.Q58*	NM_007178.3	NP_009109.3	Q9Y3F4	STRAP_HUMAN	serine/threonine kinase receptor associated protein	45					mRNA processing|RNA splicing	cell junction|mitochondrion|spliceosomal complex	identical protein binding			cervix(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(6)|skin(1)	15		Hepatocellular(102;0.121)				TATGCTACGCCAGGGAGATAC	0.363000													13	145					0	0	1	0	0
CACNA1B	774	broad.mit.edu	37	9	140846736	140846736	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr9:140846736C>T	ENST00000371372.1	+	7	1122	c.977C>T	c.(976-978)gCg>gTg	p.A326V	CACNA1B_ENST00000277551.2_Missense_Mutation_p.A326V|CACNA1B_ENST00000371357.1_Missense_Mutation_p.A326V|CACNA1B_ENST00000277549.5_5'UTR|CACNA1B_ENST00000371363.1_Missense_Mutation_p.A326V|CACNA1B_ENST00000371355.4_Missense_Mutation_p.A326V	NM_000718.3|NM_001243812.1	NP_000709.1|NP_001230741.1	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type, alpha 1B subunit	326					membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(1)|endometrium(10)|kidney(2)|large_intestine(17)|lung(31)|ovary(1)|prostate(1)|skin(2)|stomach(2)|urinary_tract(2)	80	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	ACAAACGATGCGGCCGGCAAC	0.597000													4	207					0	0	1	0	0
CALML3	810	broad.mit.edu	37	10	5567160	5567160	+	Missense_Mutation	SNP	C	C	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr10:5567160C>T	ENST00000315238.1	+	1	237	c.112C>T	c.(112-114)Cgg>Tgg	p.R38W	CALML3-AS1_ENST00000542093.1_RNA|RP11-116G8.5_ENST00000442008.2_RNA|CALML3-AS1_ENST00000545372.1_RNA	NM_005185.2	NP_005176.1	P27482	CALL3_HUMAN	calmodulin-like 3	38	EF-hand 1.						calcium ion binding			endometrium(3)|lung(2)	5						CACGGTCATGCGGTCCCTGGG	0.642000													4	150					0	0	1	0	0
DCAF4	26094	broad.mit.edu	37	14	73407031	73407031	+	Silent	SNP	G	G	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr14:73407031G>A	ENST00000555042.1	+	4	362	c.297G>A	c.(295-297)aaG>aaA	p.K99K	DCAF4_ENST00000553457.1_5'UTR|DCAF4_ENST00000509153.1_Silent_p.K99K|DCAF4_ENST00000353777.3_Silent_p.K99K|DCAF4_ENST00000394234.2_5'UTR|DCAF4_ENST00000358377.2_Silent_p.K99K	NM_001163508.1	NP_001156980.1	Q8WV16	DCAF4_HUMAN	DDB1 and CUL4 associated factor 4	99						CUL4 RING ubiquitin ligase complex				NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|skin(1)	22						TCCGGCAGAAGGAGATGGAGA	0.562000													32	285					0	0	1	0	0
BHLHE40	8553	broad.mit.edu	37	3	5025216	5025216	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr3:5025216G>A	ENST00000256495.3	+	5	1681	c.1078G>A	c.(1078-1080)Gca>Aca	p.A360T		NM_003670.2	NP_003661.1	O14503	BHE40_HUMAN	basic helix-loop-helix family, member e40	360						Golgi apparatus|nucleolus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(2)|large_intestine(1)|lung(2)|ovary(1)|skin(2)	12						CGCCTCTGCCGCAGCCCTCTC	0.602000													5	455					0	0	1	0	0
DNAH5	1767	broad.mit.edu	37	5	13900350	13900350	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr5:13900350G>A	ENST00000265104.4	-	15	2328	c.2224C>T	c.(2224-2226)Cga>Tga	p.R742*		NM_001369.2	NP_001360.1	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	742	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(6)|breast(14)|central_nervous_system(4)|cervix(2)|endometrium(23)|haematopoietic_and_lymphoid_tissue(8)|kidney(11)|large_intestine(85)|liver(1)|lung(129)|ovary(16)|pancreas(2)|prostate(5)|skin(48)|stomach(5)|upper_aerodigestive_tract(11)|urinary_tract(8)	378	Lung NSC(4;0.00476)					TATCTATCTCGTTTCTGGAAG	0.383000									Kartagener syndrome				5	236					0	0	1	0	0
ZNF814	730051	broad.mit.edu	37	19	58385762	58385762	+	Silent	SNP	C	C	G			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr19:58385762C>G	ENST00000435989.2	-	3	1230	c.996G>C	c.(994-996)tcG>tcC	p.S332S	ZNF814_ENST00000600634.1_Intron|ZNF814_ENST00000597832.1_Intron|ZNF814_ENST00000595295.1_Intron|ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000596604.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	332					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.S332S(2)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						ATTTGCTAAACGATTTCCCAC	0.358000													6	16					0	0	1	0	0
CORO7-PAM16	0	broad.mit.edu	37	16	4391484	4391484	+	Missense_Mutation	SNP	G	G	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr16:4391484G>T	ENST00000572467.1	-	29	2947	c.2879C>A	c.(2878-2880)gCc>gAc	p.A960D	PAM16_ENST00000573553.1_Missense_Mutation_p.A57D|PAM16_ENST00000318059.3_Missense_Mutation_p.A37D|PAM16_ENST00000577031.1_Missense_Mutation_p.A37D|PAM16_ENST00000575848.1_Missense_Mutation_p.A49D|PAM16_ENST00000571941.1_Missense_Mutation_p.A57D|PAM16_ENST00000576217.1_Missense_Mutation_p.A37D|CORO7-PAM16_ENST00000572274.1_5'UTR	NM_001201479.1	NP_001188408.1																					GCGTCCTCGGGCATCAGCTGC	0.652000													4	65					0.00024832	0.000258387	1	1	0
PDC	5132	broad.mit.edu	37	1	186413293	186413293	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr1:186413293G>A	ENST00000391997.2	-	4	646	c.559C>T	c.(559-561)Cct>Tct	p.P187S	PDC_ENST00000456239.2_Missense_Mutation_p.P135S|PDC_ENST00000497198.1_Missense_Mutation_p.P135S|PDC_ENST00000340129.5_Missense_Mutation_p.P187S	NM_002597.4	NP_002588.3	P20941	PHOS_HUMAN	phosducin	187					G-protein coupled receptor protein signaling pathway|phototransduction|visual perception	actin cytoskeleton|cytosol|nucleus|photoreceptor inner segment|photoreceptor outer segment	phospholipase inhibitor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(1)|prostate(1)|skin(1)	7		Breast(1374;1.53e-05)		KIRC - Kidney renal clear cell carcinoma(1967;3.23e-08)|Colorectal(1306;0.0129)		AGCAGTGTAGGAAGTACATCT	0.388000													31	329					0	0	1	0	0
COTL1	23406	broad.mit.edu	37	16	84600451	84600451	+	Nonstop_Mutation	SNP	T	T	G			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr16:84600451T>G	ENST00000262428.4	-	4	591	c.429A>C	c.(427-429)taA>taC	p.*143Y	COTL1_ENST00000564057.1_Nonstop_Mutation_p.*74Y|COTL1_ENST00000567278.1_5'UTR	NM_021149.2	NP_066972.1	Q14019	COTL1_HUMAN	coactosin-like 1 (Dictyostelium)	0						cytoplasm|cytoskeleton	actin binding|enzyme binding			endometrium(1)|large_intestine(1)|liver(1)|lung(2)|skin(1)	6						GGGGCTGGGGTTACTCCGTCT	0.622000													10	95					0	0	1	0	0
FNDC8	54752	broad.mit.edu	37	17	33457365	33457365	+	Missense_Mutation	SNP	G	G	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr17:33457365G>A	ENST00000158009.5	+	4	1002	c.887G>A	c.(886-888)cGg>cAg	p.R296Q	NLE1_ENST00000586869.1_3'UTR	NM_017559.2	NP_060029.1	Q8TC99	FNDC8_HUMAN	fibronectin type III domain containing 8	296										breast(1)|kidney(1)|large_intestine(3)|lung(3)|ovary(2)|skin(1)	11		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.022)		ATCACCGTGCGGCGCAAGGAA	0.557000													4	255					0	0	1	0	0
RP11-798G7.5	0	broad.mit.edu	37	17	43587569	43587569	+	RNA	SNP	G	G	C	rs149697015	by1000genomes	TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr17:43587569G>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							aactccgtctgaaaagaaaag	0.443000													7	176					0	0	1	0	0
DNAJC11	55735	broad.mit.edu	37	1	6727803	6727804	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr1:6727803_6727804delTC	ENST00000377577.5	-	4	466_467	c.343_344delGA	c.(343-345)afs	p.E116fs	DNAJC11_ENST00000542246.1_Frame_Shift_Del_p.E78fs|DNAJC11_ENST00000377573.5_Frame_Shift_Del_p.E26fs|DNAJC11_ENST00000349363.6_Frame_Shift_Del_p.E78fs|DNAJC11_ENST00000294401.7_Frame_Shift_Del_p.E116fs	NM_018198.3	NP_060668.2	Q9NVH1	DJC11_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 11	116					protein folding		heat shock protein binding|unfolded protein binding			NS(1)|breast(2)|endometrium(4)|kidney(2)|large_intestine(11)|lung(8)|ovary(2)|skin(1)|urinary_tract(1)	32	Ovarian(185;0.0265)|all_lung(157;0.154)	all_cancers(23;1.97e-27)|all_epithelial(116;1.76e-17)|all_lung(118;2.27e-05)|Lung NSC(185;9.97e-05)|Renal(390;0.00188)|Breast(487;0.00289)|Colorectal(325;0.00342)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.156)		Colorectal(212;2.34e-07)|COAD - Colon adenocarcinoma(227;2.05e-05)|Kidney(185;7.67e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000639)|KIRC - Kidney renal clear cell carcinoma(229;0.00128)|STAD - Stomach adenocarcinoma(132;0.00179)|READ - Rectum adenocarcinoma(331;0.0649)		TCTCCTCTCTTCTCTCTCTCTC	0.505													11	211	---	---	---	---					
NOTCH2	4853	broad.mit.edu	37	1	120612003	120612004	+	Frame_Shift_Del	DEL	GG	GG	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr1:120612003_120612004delGG	ENST00000256646.2	-	1	236_237	c.17_18delCC	c.(16-18)cfs	p.P6fs		NM_024408.3	NP_077719.2	Q04721	NOTC2_HUMAN	notch 2	6					anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity	p.P6fs*27(2)		breast(4)|central_nervous_system(6)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(9)|kidney(9)|large_intestine(19)|liver(1)|lung(57)|ovary(4)|pancreas(1)|prostate(7)|skin(24)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	158	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACAGCAGAGCGGGGCGCAGGGC	0.762			"""N, F, Mis"""		"""marginal zone lymphoma, DLBCL"""				Alagille Syndrome				20	43	---	---	---	---					
ADAMTSL4	54507	broad.mit.edu	37	1	150530506	150530506	+	Frame_Shift_Del	DEL	G	G	-	rs149280379		TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr1:150530506delG	ENST00000271643.4	+	14	2499	c.2263delG	c.(2263-2265)ggfs	p.G758fs	ADAMTSL4_ENST00000369041.5_Frame_Shift_Del_p.G758fs|ADAMTSL4_ENST00000369038.2_Frame_Shift_Del_p.G758fs|ADAMTSL4_ENST00000369039.5_Frame_Shift_Del_p.G781fs	NM_019032.4	NP_061905.2	Q6UY14	ATL4_HUMAN	ADAMTS-like 4	758	TSP type-1 2.				apoptosis|positive regulation of apoptosis		metalloendopeptidase activity|protease binding			breast(1)|cervix(1)|endometrium(6)|large_intestine(3)|lung(13)|ovary(2)|prostate(3)|skin(3)	32	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			GCAGGAATTTGGGGGGGGTGG	0.692													9	671	---	---	---	---					
CD1D	912	broad.mit.edu	37	1	158151257	158151257	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr1:158151257delT	ENST00000368171.3	+	3	573	c.74delT	c.(73-75)ctfs	p.L25fs		NM_001766.3	NP_001757.1	P15813	CD1D_HUMAN	CD1d molecule	25					antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			endometrium(1)|kidney(2)|large_intestine(2)|lung(19)|ovary(1)|prostate(3)|urinary_tract(2)	30	all_hematologic(112;0.0378)					CCGCAAAGGCTTTTCCCCCTC	0.592													7	1667	---	---	---	---					
C2orf71	388939	broad.mit.edu	37	2	29295647	29295649	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr2:29295647_29295649delTCC	ENST00000331664.5	-	1	1478_1480	c.1479_1481delGGA	c.(1477-1482)gaa>ga	p.EE493del		NM_001029883.2	NP_001025054.1	A6NGG8	CB071_HUMAN	chromosome 2 open reading frame 71	493					response to stimulus|visual perception	photoreceptor outer segment				NS(2)|breast(5)|central_nervous_system(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(20)|ovary(2)|prostate(6)|skin(3)|stomach(1)	60						CATTTTGTCTTCCTCCTCCTCCT	0.542													7	579	---	---	---	---					
ITPRIPL1	150771	broad.mit.edu	37	2	96992793	96992795	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr2:96992793_96992795delGAG	ENST00000361124.4	+	1	859_861	c.448_450delGAG	c.(448-450)del	p.E155del	ITPRIPL1_ENST00000542887.1_In_Frame_Del_p.E139del|ITPRIPL1_ENST00000536814.1_In_Frame_Del_p.E139del|ITPRIPL1_ENST00000439118.2_In_Frame_Del_p.E147del	NM_178495.5	NP_848590.3	Q6GPH6	IPIL1_HUMAN	inositol 1,4,5-trisphosphate receptor interacting protein-like 1	147						integral to membrane				breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|lung(7)|ovary(1)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						TTCCAGCAGTGAGGAGGAGGAGG	0.532													12	318	---	---	---	---					
TMEM131	23505	broad.mit.edu	37	2	98427639	98427639	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr2:98427639delT	ENST00000186436.5	-	18	2148	c.1920delA	c.(1918-1920)aafs	p.K640fs		NM_015348.1	NP_056163.1	Q92545	TM131_HUMAN	transmembrane protein 131	640						integral to membrane				NS(1)|autonomic_ganglia(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(23)|ovary(4)|prostate(1)|skin(1)|stomach(1)	57						TCCCCTCTAATTTTTTTGCAG	0.393													9	994	---	---	---	---					
GIGYF2	26058	broad.mit.edu	37	2	233712228	233712230	+	In_Frame_Del	DEL	CAG	CAG	-	rs72096937		TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr2:233712228_233712230delCAG	ENST00000373566.3	+	28	3894_3896	c.3697_3699delCAG	c.(3697-3699)del	p.Q1238del	GIGYF2_ENST00000409196.3_In_Frame_Del_p.Q1210del|GIGYF2_ENST00000409480.1_In_Frame_Del_p.Q1238del|GIGYF2_ENST00000409547.1_In_Frame_Del_p.Q1216del|GIGYF2_ENST00000409451.3_In_Frame_Del_p.Q1237del|GIGYF2_ENST00000373563.4_In_Frame_Del_p.Q1216del			Q6Y7W6	PERQ2_HUMAN	GRB10 interacting GYF protein 2	1216	Gln-rich.				cell death		protein binding	p.Q1216delQ(2)|p.Q1237delQ(1)		NS(1)|biliary_tract(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(11)|kidney(2)|large_intestine(17)|lung(11)|ovary(5)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	63		Breast(86;0.00279)|all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;7.37e-16)|BRCA - Breast invasive adenocarcinoma(100;0.000472)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Lung(119;0.0118)|GBM - Glioblastoma multiforme(43;0.0145)		gcagctgccacagcagcagcagc	0.547													7	179	---	---	---	---					
LNP1	348801	broad.mit.edu	37	3	100148586	100148588	+	In_Frame_Del	DEL	GAT	GAT	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr3:100148586_100148588delGAT	ENST00000383693.3	+	2	1293_1295	c.13_15delGAT	c.(13-15)del	p.D10del	LNP1_ENST00000489752.1_In_Frame_Del_p.D10del	NM_001085451.1	NP_001078920.1	A1A4G5	LNP1_HUMAN	leukemia NUP98 fusion partner 1	10	Poly-Asp.									cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(1)	6						GGAGCACAAAGATGATGATGATG	0.507													11	841	---	---	---	---					
ZBTB38	253461	broad.mit.edu	37	3	141162874	141162875	+	Frame_Shift_Ins	INS	-	-	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr3:141162874_141162875insA	ENST00000514251.1	+	4	1923_1924	c.1644_1645insA	c.(1642-1647)agaaaafs	p.RK548fs	ZBTB38_ENST00000321464.5_Frame_Shift_Ins_p.RK549fs|ZBTB38_ENST00000441582.2_Frame_Shift_Ins_p.RK548fs			Q8NAP3	ZBT38_HUMAN	zinc finger and BTB domain containing 38	548					positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|cervix(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(3)|lung(14)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	41						TTTCCATCAGTAAAAAAACAGC	0.386													38	254	---	---	---	---					
KIAA1211	57482	broad.mit.edu	37	4	57182265	57182267	+	In_Frame_Del	DEL	AGA	AGA	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr4:57182265_57182267delAGA	ENST00000504228.1	+	6	2702_2704	c.2597_2599delAGA	c.(2596-2601)cag>c	p.QK866del	KIAA1211_ENST00000264229.6_In_Frame_Del_p.QK866del|KIAA1211_ENST00000541073.1_In_Frame_Del_p.QK859del			Q6ZU35	K1211_HUMAN	KIAA1211	866										endometrium(7)|large_intestine(10)|lung(39)|ovary(2)|prostate(3)|skin(3)|stomach(1)	65	Glioma(25;0.08)|all_neural(26;0.101)					CAGGCAGAACAGAAGAAGAAGAA	0.567													7	177	---	---	---	---					
RP11-25H12.1	0	broad.mit.edu	37	4	66960408	66960411	+	RNA	DEL	AAAT	AAAT	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr4:66960408_66960411delAAAT	ENST00000508572.1	+	0	463																											TTCTGGtaaaaaataaataaataa	0.353													3	6	---	---	---	---					
NAP1L5	266812	broad.mit.edu	37	4	89618484	89618486	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr4:89618484_89618486delTCC	ENST00000323061.5	-	1	900_902	c.420_422delGGA	c.(418-423)gaa>ga	p.EE142del	HERC3_ENST00000402738.1_Intron|HERC3_ENST00000264345.3_Intron|HERC3_ENST00000543130.1_Intron	NM_153757.2	NP_715638.1	Q96NT1	NP1L5_HUMAN	nucleosome assembly protein 1-like 5	142	Glu-rich.				nucleosome assembly	nucleus	protein binding			endometrium(2)|lung(3)|skin(1)|upper_aerodigestive_tract(1)	7				OV - Ovarian serous cystadenocarcinoma(123;0.000181)		gtactcctcttcctcctcctcct	0.606													10	331	---	---	---	---					
SORBS2	8470	broad.mit.edu	37	4	186544439	186544439	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr4:186544439delT	ENST00000431808.1	-	14	2695	c.2132delA	c.(2131-2133)atfs	p.N711fs	SORBS2_ENST00000448662.2_Intron|SORBS2_ENST00000418609.1_Frame_Shift_Del_p.N615fs|SORBS2_ENST00000449407.2_Intron|SORBS2_ENST00000393528.3_Intron|SORBS2_ENST00000355634.5_Frame_Shift_Del_p.N811fs|SORBS2_ENST00000437304.2_Intron|SORBS2_ENST00000319471.9_Intron|SORBS2_ENST00000284776.7_Frame_Shift_Del_p.N711fs|SORBS2_ENST00000498125.1_Intron			O94875	SRBS2_HUMAN	sorbin and SH3 domain containing 2	711						actin cytoskeleton|nucleus|perinuclear region of cytoplasm|Z disc	cytoskeletal adaptor activity|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(9)|lung(21)|ovary(2)|prostate(2)|skin(4)|urinary_tract(1)	53		all_cancers(14;4.27e-52)|all_epithelial(14;6.58e-39)|all_lung(41;1.42e-13)|Lung NSC(41;3.73e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00692)|Hepatocellular(41;0.00826)|Renal(120;0.00994)|Prostate(90;0.0101)|all_hematologic(60;0.0174)|all_neural(102;0.244)		OV - Ovarian serous cystadenocarcinoma(60;1.54e-09)|BRCA - Breast invasive adenocarcinoma(30;0.000232)|GBM - Glioblastoma multiforme(59;0.000385)|STAD - Stomach adenocarcinoma(60;0.00109)|LUSC - Lung squamous cell carcinoma(40;0.0205)		AGGAGCCGAATTTTTTTTCCT	0.448													7	691	---	---	---	---					
BTN2A3P	0	broad.mit.edu	37	6	26422388	26422390	+	RNA	DEL	CCT	CCT	-	rs113134648		TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr6:26422388_26422390delCCT	ENST00000466808.2	+	0	42_44																											GGCCAGCCTCCCTCCTCCTCCTC	0.586													13	491	---	---	---	---					
CARD11	84433	broad.mit.edu	37	7	2963941	2963943	+	In_Frame_Del	DEL	GGA	GGA	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr7:2963941_2963943delGGA	ENST00000396946.4	-	15	2267_2269	c.1864_1866delTCC	c.(1864-1866)del	p.S622del		NM_032415.4	NP_115791.3	Q9BXL7	CAR11_HUMAN	caspase recruitment domain family, member 11	622					positive regulation of cytokine production|positive regulation of NF-kappaB transcription factor activity|regulation of apoptosis|T cell costimulation|T cell receptor signaling pathway	cytosol|membrane raft|plasma membrane	CARD domain binding|guanylate kinase activity			NS(1)|breast(3)|central_nervous_system(1)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(62)|kidney(11)|large_intestine(13)|lung(31)|ovary(4)|prostate(5)|skin(7)|upper_aerodigestive_tract(2)	150		Ovarian(82;0.0115)		OV - Ovarian serous cystadenocarcinoma(56;8.44e-14)		CGGATTGGTGGGAGGAGGAGGAG	0.616			Mis		DLBCL								7	300	---	---	---	---					
TWISTNB	221830	broad.mit.edu	37	7	19738111	19738113	+	In_Frame_Del	DEL	TTC	TTC	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr7:19738111_19738113delTTC	ENST00000222567.5	-	4	913_915	c.843_845delGAA	c.(841-846)aaa>aa	p.KK281del		NM_001002926.1	NP_001002926.1	Q3B726	RPA43_HUMAN	TWIST neighbor	281	Lys-rich.					microtubule cytoskeleton|nucleolus	DNA-directed RNA polymerase activity			kidney(1)|large_intestine(3)|lung(13)|ovary(1)|prostate(2)	20						CTGGTGCTTTTTCTTCTTCTTCT	0.433													7	1547	---	---	---	---					
HOXA1	3198	broad.mit.edu	37	7	27135314	27135316	+	In_Frame_Del	DEL	CGA	CGA	-	rs10951154	byFrequency	TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr7:27135314_27135316delCGA	ENST00000343060.4	-	1	277_279	c.216_218delTCG	c.(214-219)cac>ca	p.HR72del	HOXA1_ENST00000355633.5_In_Frame_Del_p.HR72del|HOTAIRM1_ENST00000495032.1_RNA	NM_005522.4	NP_005513.1	P49639	HXA1_HUMAN	homeobox A1	72	Poly-His.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(14)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						Ctgggggtggcgatggtggtggt	0.650											OREG0003750	type=REGULATORY REGION|Gene=BC031342|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	10	297	---	---	---	---					
GARS	2617	broad.mit.edu	37	7	30634583	30634585	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr7:30634583_30634585delCTG	ENST00000389266.3	+	1	287_289	c.46_48delCTG	c.(46-48)del	p.L20del		NM_002047.2	NP_002038.2	P41250	SYG_HUMAN	glycyl-tRNA synthetase	20					cell death|diadenosine tetraphosphate biosynthetic process|glycyl-tRNA aminoacylation	cytosol|mitochondrial matrix|soluble fraction	ATP binding|glycine-tRNA ligase activity|protein dimerization activity			breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(9)|ovary(1)|skin(3)|urinary_tract(1)	24					Glycine(DB00145)	TCGCGCCGCTCTGCTGCTGCTGC	0.749													9	86	---	---	---	---					
TRBV7-8	0	broad.mit.edu	37	7	142099805	142099806	+	RNA	DEL	AC	AC	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr7:142099805_142099806delAC	ENST00000390359.3	-	0	88																											TAGTCATcatacacacacacac	0.441													16	210	---	---	---	---					
TRBV6-5	0	broad.mit.edu	37	7	142180819	142180821	+	RNA	DEL	AGG	AGG	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr7:142180819_142180821delAGG	ENST00000390368.2	-	0	115																											CCTGCAGAGAAGGAGAACAAAGC	0.557													11	343	---	---	---	---					
KMT2C	58508	broad.mit.edu	37	7	151836878	151836879	+	Splice_Site	INS	-	-	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr7:151836878_151836879insA	ENST00000355193.2	-	57	14733		c.e57-2		KMT2C_ENST00000485655.2_5'UTR|KMT2C_ENST00000262189.6_Splice_Site					lysine (K)-specific methyltransferase 2C																		GCCCAGCCCCTAAAAAAAAGTG	0.411													7	419	---	---	---	---					
KCNQ3	3786	broad.mit.edu	37	8	133150232	133150233	+	Frame_Shift_Ins	INS	-	-	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr8:133150232_133150233insT	ENST00000388996.4	-	12	2019_2020	c.1599_1600insA	c.(1597-1602)aatcaafs	p.NQ533fs	KCNQ3_ENST00000519445.1_Frame_Shift_Ins_p.NQ533fs|KCNQ3_ENST00000521134.1_Frame_Shift_Ins_p.NQ413fs	NM_004519.3	NP_004510.1	O43525	KCNQ3_HUMAN	potassium voltage-gated channel, KQT-like subfamily, member 3	533					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.F534I(1)		NS(1)|breast(3)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(21)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	70	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			GTCTCCTTGAATTTTTTTTTAT	0.455													7	434	---	---	---	---					
KANK1	23189	broad.mit.edu	37	9	732475	732477	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr9:732475_732477delGAG	ENST00000382303.1	+	10	3755_3757	c.3103_3105delGAG	c.(3103-3105)del	p.E1039del	KANK1_ENST00000382293.3_In_Frame_Del_p.E881del|KANK1_ENST00000382297.2_In_Frame_Del_p.E1039del|KANK1_ENST00000489369.1_3'UTR	NM_001256876.1	NP_001243805.1	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1	1039					negative regulation of actin filament polymerization	cytoplasm				autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(7)|kidney(3)|large_intestine(9)|lung(8)|ovary(3)|pancreas(1)|prostate(3)|stomach(4)|upper_aerodigestive_tract(1)	43		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		TCTTGAAGAAGAGGAGGAGGAGG	0.463													10	628	---	---	---	---					
ANK3	288	broad.mit.edu	37	10	61831289	61831290	+	Frame_Shift_Ins	INS	-	-	T	rs28932171	byFrequency	TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr10:61831289_61831290insT	ENST00000280772.1	-	37	9540_9541	c.9349_9350insA	c.(9349-9351)catfs	p.H3117fs	ANK3_ENST00000503366.1_Intron|ANK3_ENST00000373827.2_Intron|ANK3_ENST00000355288.2_Intron	NM_020987.3	NP_066267.2	Q12955	ANK3_HUMAN	ankyrin 3, node of Ranvier (ankyrin G)	3117			I -> V (in dbSNP:rs28932171).		establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			NS(4)|breast(7)|central_nervous_system(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(5)|kidney(14)|large_intestine(30)|liver(2)|lung(59)|ovary(8)|pancreas(2)|prostate(5)|skin(26)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	196						CTGACTTATGATTTTTTTTACA	0.401													7	725	---	---	---	---					
LZTS2	84445	broad.mit.edu	37	10	102763415	102763417	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr10:102763415_102763417delCCT	ENST00000370220.1	+	2	3623_3625	c.560_562delCCT	c.(559-564)gcc>g	p.AS187del	LZTS2_ENST00000370223.3_In_Frame_Del_p.AS187del			Q9BRK4	LZTS2_HUMAN	leucine zipper, putative tumor suppressor 2	187	Required for centrosomal localization (By similarity).				cell division|mitosis|Wnt receptor signaling pathway	membrane|microtubule|microtubule organizing center				breast(1)|large_intestine(6)|lung(7)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	22				Epithelial(162;7.3e-09)|all cancers(201;3.72e-07)		GGGGGCCCTGcctcctcctcctc	0.650													11	886	---	---	---	---					
INA	9118	broad.mit.edu	37	10	105048271	105048273	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr10:105048271_105048273delGAG	ENST00000369849.4	+	3	1394_1396	c.1345_1347delGAG	c.(1345-1347)del	p.E454del		NM_032727.3	NP_116116.1	Q16352	AINX_HUMAN	internexin neuronal intermediate filament protein, alpha	454	Poly-Glu.|Tail.				cell differentiation|nervous system development	neurofilament	structural constituent of cytoskeleton	p.E449_E450delEE(1)		breast(2)|endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(2)	13				Epithelial(162;3.45e-09)|all cancers(201;9.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.198)		ACTTAAGAAAGAGGAGGAGGAGG	0.458													11	431	---	---	---	---					
KCNA4	3739	broad.mit.edu	37	11	30034029	30034031	+	In_Frame_Del	DEL	TGG	TGG	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr11:30034029_30034031delTGG	ENST00000328224.6	-	2	1428_1430	c.195_197delCCA	c.(193-198)cag>ca	p.HQ65del		NM_002233.3	NP_002224.1	P22459	KCNA4_HUMAN	potassium voltage-gated channel, shaker-related subfamily, member 4	65	Poly-His.					voltage-gated potassium channel complex	potassium ion binding|protein binding|voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(17)|lung(39)|ovary(3)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	78						CCCGCGTGACTGGTGGTGGTGGT	0.660													7	383	---	---	---	---					
CHRM4	1132	broad.mit.edu	37	11	46407277	46407277	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr11:46407277delC	ENST00000433765.2	-	1	830	c.831delG	c.(829-831)ccfs	p.P278fs		NM_000741.2	NP_000732.2	P08173	ACM4_HUMAN	cholinergic receptor, muscarinic 4	278					cell proliferation	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity			breast(1)|endometrium(7)|kidney(1)|large_intestine(1)|lung(6)|prostate(3)|skin(1)	20				GBM - Glioblastoma multiforme(35;0.0254)|Lung(87;0.14)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)|Tropicamide(DB00809)	GCAGCGCTGGCGGGGGGGCCT	0.672													12	125	---	---	---	---					
PAK1	5058	broad.mit.edu	37	11	77069990	77069992	+	In_Frame_Del	DEL	CAT	CAT	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr11:77069990_77069992delCAT	ENST00000356341.3	-	6	1079_1081	c.548_550delATG	c.(547-552)gct>g	p.DA183del	PAK1_ENST00000278568.4_In_Frame_Del_p.DA183del|PAK1_ENST00000525542.1_5'UTR|PAK1_ENST00000528203.1_In_Frame_Del_p.DA85del|PAK1_ENST00000530617.1_In_Frame_Del_p.DA183del	NM_002576.4	NP_002567.3	Q13153	PAK1_HUMAN	p21 protein (Cdc42/Rac)-activated kinase 1	183	Interaction with CRIPAK.				apoptosis|axon guidance|cytoskeleton organization|ER-nucleus signaling pathway|positive regulation of JUN kinase activity|positive regulation of peptidyl-serine phosphorylation|protein autophosphorylation|T cell costimulation|T cell receptor signaling pathway	cytosol|focal adhesion|Golgi apparatus	ATP binding|collagen binding|protein binding|protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(13)|skin(2)|stomach(1)	29	all_cancers(14;1.75e-18)					GGTGGGGTAGcatcatcatcatc	0.478													9	485	---	---	---	---					
KDM5A	5927	broad.mit.edu	37	12	416952	416953	+	Frame_Shift_Ins	INS	-	-	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr12:416952_416953insT	ENST00000399788.2	-	23	3959_3960	c.3597_3598insA	c.(3595-3600)aagatcfs	p.I1200fs	KDM5A_ENST00000382815.4_Frame_Shift_Ins_p.I1200fs	NM_001042603.1	NP_001036068.1	P29375	KDM5A_HUMAN	lysine (K)-specific demethylase 5A	1200					chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|breast(4)|central_nervous_system(2)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(29)|ovary(1)|prostate(5)|skin(6)|stomach(1)|urinary_tract(2)	77						CAGCTGGATCCTTTTTTTTGGG	0.475			T	NUP98	AML								8	452	---	---	---	---					
KRT73	319101	broad.mit.edu	37	12	53001991	53001991	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr12:53001991delT	ENST00000305748.3	-	9	1646	c.1612delA	c.(1612-1614)ccfs	p.T538fs	RP11-641A6.2_ENST00000551089.1_RNA	NM_175068.2	NP_778238.1	Q86Y46	K2C73_HUMAN	keratin 73	538	Tail.					keratin filament	structural molecule activity			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(9)|lung(22)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	44				BRCA - Breast invasive adenocarcinoma(357;0.189)		TATCTCATGGTTTTTTTGGTG	0.532													8	704	---	---	---	---					
KRT76	51350	broad.mit.edu	37	12	53170672	53170672	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr12:53170672delC	ENST00000332411.2	-	1	457	c.404delG	c.(403-405)gtfs	p.G136fs		NM_015848.4	NP_056932.2	Q01546	K22O_HUMAN	keratin 76	136	Head.				cytoskeleton organization	keratin filament	structural molecule activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	27						gccaggcccaccaaatacacc	0.582													14	101	---	---	---	---					
TPCN1	53373	broad.mit.edu	37	12	113704096	113704098	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr12:113704096_113704098delCTG	ENST00000550785.1	+	5	734_736	c.565_567delCTG	c.(565-567)del	p.L194del	TPCN1_ENST00000335509.6_In_Frame_Del_p.L122del|TPCN1_ENST00000541517.1_In_Frame_Del_p.L194del|TPCN1_ENST00000392569.4_In_Frame_Del_p.L54del	NM_001143819.1	NP_001137291.1	Q9ULQ1	TPC1_HUMAN	two pore segment channel 1	122						endosome membrane|integral to membrane|lysosomal membrane	NAADP-sensitive calcium-release channel activity|voltage-gated ion channel activity			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(7)|lung(16)|ovary(2)|prostate(3)|skin(3)|urinary_tract(1)	40						GGCCACGGCCCTGCTGCTGCTGC	0.640													31	1617	---	---	---	---					
RP11-248G5.8	0	broad.mit.edu	37	13	52796688	52796688	+	RNA	DEL	C	C	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr13:52796688delC	ENST00000451298.1	-	0	1229				RP11-64P12.8_ENST00000606031.1_RNA																							cgctattgctccccacccatc	0.537													13	73	---	---	---	---					
RP11-597A11.1	0	broad.mit.edu	37	14	20086381	20086382	+	RNA	INS	-	-	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr14:20086381_20086382insT	ENST00000548261.1	+	0	135																											GTCTTACAAGGTAAAAAAAATG	0.312													8	38	---	---	---	---					
BEGAIN	57596	broad.mit.edu	37	14	101005271	101005273	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr14:101005271_101005273delCCT	ENST00000556751.1	-	5	4027_4029	c.623_625delAGG	c.(622-627)gcc>g	p.EA210del	BEGAIN_ENST00000443071.2_In_Frame_Del_p.EA274del|BEGAIN_ENST00000355173.2_In_Frame_Del_p.EA274del			Q9BUH8	BEGIN_HUMAN	brain-enriched guanylate kinase-associated	274						cytoplasm|membrane	protein binding			cervix(1)|endometrium(4)|large_intestine(2)|lung(3)|prostate(1)|skin(2)|stomach(1)	14		Melanoma(154;0.212)				GCCGCCTCGGCCTCCTCCTCCTC	0.724													8	74	---	---	---	---					
MESDC2	23184	broad.mit.edu	37	15	81271633	81271633	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr15:81271633delT	ENST00000261758.4	-	3	718	c.632delA	c.(631-633)agfs	p.K212fs		NM_015154.1	NP_055969.1	Q14696	MESD_HUMAN	mesoderm development candidate 2	212					mesoderm development|protein folding|Wnt receptor signaling pathway	endoplasmic reticulum		p.K211fs*6(1)		cervix(1)|large_intestine(5)|ovary(1)|urinary_tract(1)	8						TCCTTCCTTCTTTTTTTTGCC	0.493													8	241	---	---	---	---					
RAB40C	57799	broad.mit.edu	37	16	677579	677580	+	Frame_Shift_Ins	INS	-	-	C			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr16:677579_677580insC	ENST00000535977.1	+	7	1025_1026	c.803_804insC	c.(802-804)accfs	p.T268fs	RAB40C_ENST00000538492.1_Frame_Shift_Ins_p.T268fs|RAB40C_ENST00000539661.1_Frame_Shift_Ins_p.T268fs|RAB40C_ENST00000248139.3_Frame_Shift_Ins_p.T268fs	NM_001172663.1	NP_001166134.1	Q96S21	RB40C_HUMAN	RAB40C, member RAS oncogene family	268					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding	p.Q271fs*7(1)		NS(1)|endometrium(2)|large_intestine(1)|lung(1)|prostate(1)	6		Hepatocellular(780;0.0218)				CCACCCCAGAGCCCCCCCCAGA	0.678													10	381	---	---	---	---					
RABEP2	79874	broad.mit.edu	37	16	28931200	28931202	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr16:28931200_28931202delCTG	ENST00000358201.4	-	3	925_927	c.337_339delCAG	c.(337-339)del	p.Q113del	RABEP2_ENST00000544477.1_In_Frame_Del_p.Q42del|RABEP2_ENST00000561803.1_5'UTR|RABEP2_ENST00000357573.6_In_Frame_Del_p.Q113del	NM_024816.2	NP_079092.2	Q9H5N1	RABE2_HUMAN	rabaptin, RAB GTPase binding effector protein 2	113	Poly-Gln.				endocytosis|protein transport	early endosome	growth factor activity|GTPase activator activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)	16						CCTCACAGTCCTGCTGCTGCTGC	0.640													7	283	---	---	---	---					
AC012322.1	0	broad.mit.edu	37	16	64294574	64294575	+	RNA	INS	-	-	A	rs111520540		TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr16:64294574_64294575insA	ENST00000561657.1	-	0	584																											CACACACCGTTAAAAAAAAAAC	0.490													10	101	---	---	---	---					
SLC9A5	6553	broad.mit.edu	37	16	67300017	67300019	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr16:67300017_67300019delGAG	ENST00000299798.11	+	15	2172_2174	c.2107_2109delGAG	c.(2107-2109)del	p.E708del		NM_004594.2	NP_004585.1	Q14940	SL9A5_HUMAN	solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5	708					regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			breast(1)|cervix(1)|endometrium(5)|kidney(4)|large_intestine(3)|lung(9)|ovary(2)|pancreas(1)|prostate(1)	27		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)		CGTGGAGTCTGAGGAGGAGGAGG	0.571													7	241	---	---	---	---					
ZFHX3	463	broad.mit.edu	37	16	72991713	72991715	+	In_Frame_Del	DEL	CCA	CCA	-	rs4788682	by1000genomes	TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr16:72991713_72991715delCCA	ENST00000268489.5	-	2	3002_3004	c.2330_2332delTGG	c.(2329-2334)gct>g	p.VA777del	ZFHX3_ENST00000397992.5_Intron	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	777	Poly-Ala.		V -> A (in dbSNP:rs4788682).		muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding	p.V777V(1)		NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				gccgccgcagccaccgccgccgc	0.635													10	362	---	---	---	---					
CHD3	1107	broad.mit.edu	37	17	7801857	7801859	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr17:7801857_7801859delAAG	ENST00000380358.4	+	13	2273_2275	c.2272_2274delAAG	c.(2272-2274)del	p.K762del	CHD3_ENST00000358181.4_In_Frame_Del_p.K703del|CHD3_ENST00000330494.7_In_Frame_Del_p.K703del	NM_001005271.2	NP_001005271.2	Q12873	CHD3_HUMAN	chromodomain helicase DNA binding protein 3	703	Helicase ATP-binding.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|cervix(2)|endometrium(11)|kidney(6)|large_intestine(13)|liver(2)|lung(14)|ovary(1)|pancreas(1)|prostate(7)|skin(3)|urinary_tract(2)	65		Prostate(122;0.202)				CCGCAAGTATAAGAAGAAGAAGA	0.488													7	215	---	---	---	---					
UPF3AP2	0	broad.mit.edu	37	17	20279655	20279655	+	RNA	DEL	T	T	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr17:20279655delT	ENST00000578315.1	-	0	51																											tctgtctctcttttttttttt	0.383													10	10	---	---	---	---					
SUPT6H	6830	broad.mit.edu	37	17	27027202	27027204	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr17:27027202_27027204delAGC	ENST00000314616.6	+	34	4856_4858	c.4573_4575delAGC	c.(4573-4575)del	p.S1528del	SUPT6H_ENST00000347486.4_In_Frame_Del_p.S1528del	NM_003170.3	NP_003161.2	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog (S. cerevisiae)	1528	Poly-Ser.				chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	Lung NSC(42;0.00431)					CATCACCCCTAGCAGCAGCAGCA	0.537													8	1061	---	---	---	---					
GAS2L2	246176	broad.mit.edu	37	17	34071994	34071996	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr17:34071994_34071996delTCC	ENST00000254466.6	-	6	2547_2549	c.2520_2522delGGA	c.(2518-2523)gaa>ga	p.EE840del	GAS2L2_ENST00000587565.1_In_Frame_Del_p.EE824del	NM_139285.3	NP_644814.1	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	840					cell cycle arrest	cytoplasm|cytoskeleton				central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	35		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		ctcctttccttcctcctcctcct	0.616													11	251	---	---	---	---					
KRTAP4-1	85285	broad.mit.edu	37	17	39340796	39340852	+	In_Frame_Del	DEL	CGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	CGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	-	rs483929	by1000genomes	TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr17:39340796_39340852delCGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGG	ENST00000398472.1	-	1	742_798	c.255_311delCCCACTCTGCTGTCAGACCACCTGCCACCCCAGCTGTGGTATGTCCAGCTGCTGCCG	c.(253-312)cgt>cg	p.RPLCCQTTCHPSCGMSSCCR85del				Q9BYQ7	KRA41_HUMAN	keratin associated protein 4-1	85	18 X 5 AA repeats of C-C-[GRQC]-[SPT]- [VSTL].		Missing (in allele KAP4.10).			keratin filament		p.H90_C108delHPSCGMSSCCRPLCCQTTC(2)|p.H94_C112delHPSCGMSSCCRPLCCQTTC(2)		kidney(1)|large_intestine(1)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	5		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000449)			ACAGAGTGGACGGCAGCAGCTGGACATACCACAGCTGGGGTGGCAGGTGGTCTGACAGCAGAGTGGGCGGCAGCAGC	0.646													30	326	---	---	---	---					
COIL	8161	broad.mit.edu	37	17	55028015	55028016	+	Frame_Shift_Ins	INS	-	-	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr17:55028015_55028016insT	ENST00000240316.4	-	2	621_622	c.587_588insA	c.(586-588)agcfs	p.S196fs		NM_004645.2	NP_004636.1	P38432	COIL_HUMAN	coilin	196	Lys-rich (basic).					Cajal body|nucleolus	protein C-terminus binding			NS(1)|endometrium(4)|kidney(1)|large_intestine(1)|lung(4)|ovary(1)|prostate(2)|urinary_tract(1)	15	Breast(9;6.15e-08)					GATTCTTAGCCTTTTTTTTATA	0.396													7	452	---	---	---	---					
RP11-178C3.2	0	broad.mit.edu	37	17	58064623	58064624	+	RNA	INS	-	-	T	rs11447022		TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr17:58064623_58064624insT	ENST00000586209.1	+	0	158																											tttTTTTGGTGTTTTTtttttt	0.356													5	9	---	---	---	---					
FTSJ3	117246	broad.mit.edu	37	17	61899155	61899157	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr17:61899155_61899157delCTC	ENST00000427159.2	-	15	2167_2169	c.1522_1524delGAG	c.(1522-1524)del	p.E508del		NM_017647.3	NP_060117.3	Q8IY81	RRMJ3_HUMAN	FtsJ homolog 3 (E. coli)	508					RNA methylation|rRNA processing	nucleolus	methyltransferase activity|nucleic acid binding			breast(2)|central_nervous_system(1)|endometrium(6)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	27						GCAGTGGATTCTCCTCCTCCTCC	0.537													7	801	---	---	---	---					
SRP68	6730	broad.mit.edu	37	17	74068528	74068530	+	In_Frame_Del	DEL	GCC	GCC	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr17:74068528_74068530delGCC	ENST00000307877.2	-	1	204_206	c.43_45delGGC	c.(43-45)del	p.G15del	SRP68_ENST00000539137.1_In_Frame_Del_p.G15del|SRP68_ENST00000355113.5_5'UTR	NM_014230.3	NP_055045.2	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa	15	Poly-Gly.			Missing (in Ref. 1).	response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding			NS(1)|cervix(1)|endometrium(3)|kidney(4)|large_intestine(5)|lung(4)|ovary(2)|prostate(3)	23						cgccgccactgccgccgccgccg	0.709													8	258	---	---	---	---					
DNMT1	1786	broad.mit.edu	37	19	10262139	10262139	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr19:10262139delT	ENST00000340748.4	-	23	2387	c.2152delA	c.(2152-2154)tgfs	p.M718fs	DNMT1_ENST00000359526.4_Frame_Shift_Del_p.M734fs|DNMT1_ENST00000540357.1_Frame_Shift_Del_p.M718fs			P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1	718					chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			breast(5)|endometrium(8)|kidney(5)|large_intestine(21)|lung(11)|ovary(2)|pancreas(1)|prostate(10)|skin(5)|stomach(1)|urinary_tract(1)	70			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	CCCTGGTGCATTTTTTTGGGT	0.507													8	754	---	---	---	---					
RYR1	6261	broad.mit.edu	37	19	38948159	38948160	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr19:38948159_38948160delTG	ENST00000355481.4	+	17	1945_1946	c.1814_1815delTG	c.(1813-1815)cfs	p.L605fs	RYR1_ENST00000360985.3_Frame_Shift_Del_p.L605fs|RYR1_ENST00000359596.3_Frame_Shift_Del_p.L605fs	NM_000540.2|NM_001042723.1	NP_000531.2|NP_001036188.1	P21817	RYR1_HUMAN	ryanodine receptor 1 (skeletal)	605	B30.2/SPRY 1.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			NS(4)|autonomic_ganglia(2)|breast(3)|central_nervous_system(5)|endometrium(26)|haematopoietic_and_lymphoid_tissue(3)|kidney(34)|large_intestine(42)|liver(1)|lung(106)|ovary(11)|pancreas(5)|prostate(9)|skin(12)|stomach(11)|upper_aerodigestive_tract(4)|urinary_tract(7)	285	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	CTATGCTCCCTGTGTGTGTGTA	0.530													9	1153	---	---	---	---					
FUZ	80199	broad.mit.edu	37	19	50310483	50310485	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr19:50310483_50310485delCAG	ENST00000313777.4	-	11	1343_1345	c.1180_1182delCTG	c.(1180-1182)del	p.L394del	FUZ_ENST00000528094.1_In_Frame_Del_p.L358del|FUZ_ENST00000445575.2_Intron|FUZ_ENST00000533418.1_In_Frame_Del_p.L344del	NM_025129.4	NP_079405.2	Q9BT04	FUZZY_HUMAN	fuzzy planar cell polarity protein	394	Leu-rich.				cilium assembly|embryonic body morphogenesis|embryonic skeletal system morphogenesis|establishment of planar polarity|hair follicle development|neural tube closure|protein transport|regulation of smoothened signaling pathway	cytoplasm|cytoskeleton				endometrium(1)|lung(3)	4		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00793)|GBM - Glioblastoma multiforme(134;0.0116)		TCTGGGGAGACAGCAGCAGCAGC	0.635													10	248	---	---	---	---					
TMC4	147798	broad.mit.edu	37	19	54675747	54675749	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr19:54675747_54675749delTCC	ENST00000376591.4	-	2	332_334	c.201_203delGGA	c.(199-204)gat>ga	p.ED67del	TMC4_ENST00000301187.4_In_Frame_Del_p.ED61del	NM_001145303.1|NM_144686.2	NP_001138775.1|NP_653287.1	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4	67	Poly-Glu.					integral to membrane				breast(2)|endometrium(7)|large_intestine(4)|lung(6)|pancreas(1)|skin(1)|urinary_tract(1)	22	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CCTTCCTCCATCCTCCTCCTCCT	0.645													10	329	---	---	---	---					
LILRB2	0	broad.mit.edu	37	19	54780707	54780709	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr19:54780707_54780709delGAG	ENST00000391748.1	-	10	1559_1561	c.1432_1434delCTC	c.(1432-1434)del	p.L478del	LILRB2_ENST00000314446.5_In_Frame_Del_p.L478del|LILRB2_ENST00000391746.1_In_Frame_Del_p.L479del|LILRB2_ENST00000434421.1_In_Frame_Del_p.L363del|LILRB2_ENST00000391749.4_In_Frame_Del_p.L479del	NM_001278403.1	NP_001265332.1	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2	479					cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity	p.L479L(1)		breast(2)|endometrium(3)|kidney(1)|large_intestine(4)|lung(30)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	44	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ggatgaggaagaggaggaggagg	0.611													8	440	---	---	---	---					
SLC23A2	9962	broad.mit.edu	37	20	4850569	4850569	+	Frame_Shift_Del	DEL	G	G	-	rs138961929		TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr20:4850569delG	ENST00000379333.1	-	12	1625	c.1233delC	c.(1231-1233)ccfs	p.P411fs	SLC23A2_ENST00000468355.1_5'UTR|SLC23A2_ENST00000338244.1_Frame_Shift_Del_p.P411fs|SLC23A2_ENST00000424750.2_Frame_Shift_Del_p.P297fs	NM_203327.1	NP_976072.1	Q9UGH3	S23A2_HUMAN	solute carrier family 23 (ascorbic acid transporter), member 2	411					L-ascorbic acid metabolic process|molecular hydrogen transport|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transepithelial L-ascorbic acid transport	apical plasma membrane|integral to plasma membrane|membrane fraction	nucleobase transmembrane transporter activity|sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent multivitamin transmembrane transporter activity	p.I412fs*4(1)		endometrium(1)|kidney(3)|large_intestine(9)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	27						TTGCGTGGATGGGGGGGGGTG	0.527													14	375	---	---	---	---					
RP4-777D9.2	0	broad.mit.edu	37	20	21143813	21143814	+	RNA	INS	-	-	T			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr20:21143813_21143814insT	ENST00000591761.1	-	0	5051				PLK1S1_ENST00000457464.1_RNA																							AAGCCATTCAATTTTTTTTTTC	0.371													13	313	---	---	---	---					
DDX27	55661	broad.mit.edu	37	20	47858504	47858504	+	Frame_Shift_Del	DEL	A	A	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr20:47858504delA	ENST00000371764.4	+	17	2074	c.2065delA	c.(2065-2067)aafs	p.K691fs	DDX27_ENST00000484427.1_3'UTR|ZNFX1_ENST00000371754.4_Intron|ZNFX1_ENST00000469991.1_Intron	NM_017895.7	NP_060365.7	Q96GQ7	DDX27_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27	691						nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding	p.K691fs*4(3)		NS(1)|breast(1)|endometrium(2)|kidney(3)|large_intestine(12)|lung(19)|ovary(1)|prostate(2)|skin(3)|urinary_tract(1)	45			BRCA - Breast invasive adenocarcinoma(12;0.000899)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)			GAAGGATGCCAAAAAAAAGGG	0.488													13	385	---	---	---	---					
SLC9A8	23315	broad.mit.edu	37	20	48467301	48467301	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr20:48467301delT	ENST00000417961.1	+	7	747	c.537delT	c.(535-537)ggfs	p.G179fs	SLC9A8_ENST00000361573.2_Intron|SLC9A8_ENST00000541138.1_Intron|SLC9A8_ENST00000539601.1_Intron	NM_001260491.1|NM_015266.2	NP_001247420.1|NP_056081.1	Q9Y2E8	SL9A8_HUMAN	solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8	178						Golgi membrane|integral to membrane	sodium:hydrogen antiporter activity			NS(1)|autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(8)|lung(9)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	30			BRCA - Breast invasive adenocarcinoma(9;3.91e-07)			TTCTCCAGGGTTTTTTTTTTG	0.333													14	119	---	---	---	---					
ANKRD20A11P	0	broad.mit.edu	37	21	15343608	15343609	+	RNA	INS	-	-	A			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr21:15343608_15343609insA	ENST00000344693.5	-	0	736					NR_027270.1																						TAAAACAGCAGAAAAAATTAAT	0.272													13	330	---	---	---	---					
CBR3	874	broad.mit.edu	37	21	37510175	37510175	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr21:37510175delT	ENST00000290354.5	+	2	623	c.342delT	c.(340-342)aafs	p.N114fs	CBR3-AS1_ENST00000413862.1_RNA|CBR3-AS1_ENST00000453159.1_RNA	NM_001236.3	NP_001227.1	O75828	CBR3_HUMAN	carbonyl reductase 3	114						cytosol|nucleus	carbonyl reductase (NADPH) activity|NADPH binding			kidney(1)|large_intestine(1)|lung(1)	3						TGAAGACAAATTTTTTTGCCA	0.408													8	492	---	---	---	---					
BACE2	25825	broad.mit.edu	37	21	42647459	42647461	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr21:42647459_42647461delCTG	ENST00000330333.6	+	9	1928_1930	c.1465_1467delCTG	c.(1465-1467)del	p.L492del	BACE2_ENST00000347667.4_In_Frame_Del_p.L442del|BACE2_ENST00000466122.1_3'UTR|BACE2_ENST00000328735.6_3'UTR	NM_012105.3	NP_036237.2	Q9Y5Z0	BACE2_HUMAN	beta-site APP-cleaving enzyme 2	492					membrane protein ectodomain proteolysis|negative regulation of amyloid precursor protein biosynthetic process|peptide hormone processing	cell surface|endoplasmic reticulum|endosome|Golgi apparatus|integral to membrane	aspartic-type endopeptidase activity			endometrium(2)|large_intestine(3)|lung(4)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	14		Prostate(19;1.57e-07)|all_epithelial(19;0.0251)				CTTAATCGTCCTGCTGCTGCTGC	0.567													9	227	---	---	---	---					
PTTG1IP	754	broad.mit.edu	37	21	46276194	46276196	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr21:46276194_46276196delGCA	ENST00000330938.3	-	4	581_583	c.361_363delTGC	c.(361-363)del	p.C121del	PTTG1IP_ENST00000494690.1_5'UTR|PTTG1IP_ENST00000397887.3_Intron|PTTG1IP_ENST00000445724.2_Intron|PTTG1IP_ENST00000397886.3_In_Frame_Del_p.C100del	NM_004339.3	NP_004330.1	P53801	PTTG_HUMAN	pituitary tumor-transforming 1 interacting protein	121	Poly-Cys.				protein import into nucleus	cytoplasm|integral to membrane|nucleus				ovary(1)|prostate(1)	2				Colorectal(79;0.0659)		TCTTCCTCCTGCAGCAGCAGCAG	0.616													10	298	---	---	---	---					
PIWIL3	440822	broad.mit.edu	37	22	25150021	25150021	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr22:25150021delC	ENST00000332271.5	-	8	1353	c.937delG	c.(937-939)aafs	p.E313fs	PIWIL3_ENST00000533313.1_Frame_Shift_Del_p.E204fs|PIWIL3_ENST00000527701.1_Frame_Shift_Del_p.E204fs|PIWIL3_ENST00000532537.2_5'UTR	NM_001008496.3|NM_001255975.1	NP_001008496.2|NP_001242904.1	Q7Z3Z3	PIWL3_HUMAN	piwi-like RNA-mediated gene silencing 3	313	PAZ.				cell differentiation|gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatogenesis	cytoplasm	RNA binding			NS(1)|breast(4)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(14)|lung(15)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	50						TTAGTTACTTCCTCTCGGATG	0.428													52	303	---	---	---	---					
ARFGAP3	26286	broad.mit.edu	37	22	43230269	43230269	+	Frame_Shift_Del	DEL	A	A	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chr22:43230269delA	ENST00000263245.5	-	5	675	c.456delT	c.(454-456)ttfs	p.F152fs	ARFGAP3_ENST00000437119.2_Frame_Shift_Del_p.F108fs|ARFGAP3_ENST00000429508.2_Intron	NM_001142293.1|NM_014570.4	NP_001135765.1|NP_055385.3	Q9NP61	ARFG3_HUMAN	ADP-ribosylation factor GTPase activating protein 3	152					intracellular protein transport|protein secretion|regulation of ARF GTPase activity|vesicle-mediated transport	cytosol|Golgi membrane	ARF GTPase activator activity|protein transporter activity|zinc ion binding			breast(3)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)	11						CGTGAGAGGCAAAAAAATCTT	0.398													7	619	---	---	---	---					
PRRG1	5638	broad.mit.edu	37	X	37312610	37312611	+	Frame_Shift_Ins	INS	-	-	C			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chrX:37312610_37312611insC	ENST00000542554.1	+	5	665_666	c.393_394insC	c.(391-396)ccccccfs	p.PP131fs	PRRG1_ENST00000378628.4_Frame_Shift_Ins_p.PP131fs|PRRG1_ENST00000543642.1_Frame_Shift_Ins_p.PP131fs|TM4SF2_ENST00000465127.1_Intron|PRRG1_ENST00000491253.1_3'UTR|PRRG1_ENST00000449135.2_Frame_Shift_Ins_p.PP131fs	NM_001173489.1	NP_001166960.1	O14668	TMG1_HUMAN	proline rich Gla (G-carboxyglutamic acid) 1	131	Poly-Pro.					extracellular region|integral to plasma membrane	calcium ion binding	p.P135fs*3(1)|p.P134fs*19(1)		breast(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)	15						TTATCACCCCACCCCCCCCACC	0.485													7	346	---	---	---	---					
MED12	9968	broad.mit.edu	37	X	70360648	70360650	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chrX:70360648_70360650delCAG	ENST00000333646.6	+	42	6416_6418	c.6217_6219delCAG	c.(6217-6219)del	p.Q2079del	MED12_ENST00000374080.3_In_Frame_Del_p.Q2076del|MED12_ENST00000374102.1_In_Frame_Del_p.Q2075del|MED12_ENST00000478889.1_3'UTR	NM_005120.2	NP_005111.2	Q93074	MED12_HUMAN	mediator complex subunit 12	2076	Gln-rich.				androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(6)|central_nervous_system(2)|endometrium(22)|kidney(5)|large_intestine(8)|lung(31)|ovary(2)|pancreas(1)|prostate(11)|skin(5)|soft_tissue(323)|upper_aerodigestive_tract(1)|urinary_tract(3)	420	Renal(35;0.156)					gcaacagcaacagcagcagcagc	0.621			"""M, S"""		uterine leiomyoma		Opitz-Kaveggia Syndrome						7	155	---	---	---	---					
MAGEC1	9947	broad.mit.edu	37	X	140994639	140994641	+	In_Frame_Del	DEL	CTC	CTC	-	rs144357389	byFrequency	TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chrX:140994639_140994641delCTC	ENST00000285879.4	+	4	1735_1737	c.1449_1451delCTC	c.(1447-1452)agc>ag	p.SS487del	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	487							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TTCCTGTGAGCTCCTCCTCCTCC	0.473										HNSCC(15;0.026)			9	648	---	---	---	---					
MAMLD1	10046	broad.mit.edu	37	X	149639325	149639327	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chrX:149639325_149639327delCAG	ENST00000370401.2	+	4	1790_1792	c.1480_1482delCAG	c.(1480-1482)del	p.Q502del	MAMLD1_ENST00000262858.5_In_Frame_Del_p.Q502del|MAMLD1_ENST00000432680.2_In_Frame_Del_p.Q477del|MAMLD1_ENST00000455522.2_5'UTR|MAMLD1_ENST00000426613.2_In_Frame_Del_p.Q477del			Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	502	Poly-Gln.				male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus		p.Q469Q(1)|p.Q494Q(1)|p.Q421Q(1)		breast(1)|endometrium(4)|kidney(3)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)	37	Acute lymphoblastic leukemia(192;6.56e-05)					AAGCcagcaacagcagcagcagc	0.532													7	186	---	---	---	---					
MAGEA10	4109	broad.mit.edu	37	X	151303906	151303908	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-FB-A7DR-01A-21D-A33T-08	TCGA-FB-A7DR-10A-01D-A33W-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	87b35eca-4050-432c-910e-873dbe3cf8ea	df8901cd-b022-4674-bb97-2d67a7c132cc	g.chrX:151303906_151303908delAGG	ENST00000370323.4	-	4	501_503	c.185_187delCCT	c.(184-189)tgc>t	p.SC62del	MAGEA10_ENST00000244096.3_In_Frame_Del_p.SC62del|RP11-1007I13.4_ENST00000509345.2_RNA	NM_001251828.1|NM_021048.4	NP_001238757.1|NP_066386.2	P43363	MAGAA_HUMAN	melanoma antigen family A, 10	62	Poly-Ser.									endometrium(2)|kidney(2)|large_intestine(4)|lung(11)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					AGAGGATAGCaggaggaggagga	0.562													7	315	---	---	---	---					
