Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
NBPF1	55672	broad.mit.edu	37	1	16918653	16918653	+	Splice_Site	SNP	C	C	T			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:16918653C>T	ENST00000430580.2	-	6	853		c.e6+1			NM_017940.3	NP_060410.2	Q3BBV0	NBPF1_HUMAN	neuroblastoma breakpoint family, member 1							cytoplasm									UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		TCTTAACTTACTGTTGTGAAA	0.418000													20	227					0	0	1	0	0
KCNN3	3782	broad.mit.edu	37	1	154842333	154842333	+	Silent	SNP	C	C	T			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:154842333C>T	ENST00000271915.3	-	1	423	c.108G>A	c.(106-108)caG>caA	p.Q36Q		NM_002249.5	NP_002240.3	Q9UGI6	KCNN3_HUMAN	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3	36	Poly-Gln.					integral to membrane	calmodulin binding			cervix(1)|endometrium(3)|kidney(2)|large_intestine(6)|lung(11)|prostate(4)|skin(1)	28	all_lung(78;2.29e-27)|all_hematologic(923;0.088)|Hepatocellular(266;0.108)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00819)			gctgctgttgctgctgctgct	0.672000													3	48					0	0	1	0	0
ZNF131	7690	broad.mit.edu	37	5	43161989	43161989	+	Missense_Mutation	SNP	T	T	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr5:43161989T>G	ENST00000509634.1	+	5	1364	c.908T>G	c.(907-909)tTt>tGt	p.F303C	ZNF131_ENST00000306938.4_Missense_Mutation_p.F303C|ZNF131_ENST00000399534.1_Missense_Mutation_p.F337C|ZNF131_ENST00000505606.2_Missense_Mutation_p.F303C|ZNF131_ENST00000509156.1_Missense_Mutation_p.F337C|ZNF131_ENST00000509931.1_Intron			P52739	ZN131_HUMAN	zinc finger protein 131	337						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	17						GAGAAACAGTTTGACCATTTT	0.328000													7	282					0	0	1	0	0
KIAA0907	22889	broad.mit.edu	37	1	155887399	155887399	+	Missense_Mutation	SNP	T	T	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:155887399T>G	ENST00000368320.3	-	11	1356	c.1331A>C	c.(1330-1332)cAg>cCg	p.Q444P	KIAA0907_ENST00000368321.3_Missense_Mutation_p.Q444P			Q7Z7F0	K0907_HUMAN	KIAA0907	444	Pro-rich.							p.Q444P(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|urinary_tract(1)	21	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			gggctggggctggggGCCAGC	0.562000													24	178					0	0	1	0	0
ZFHX3	463	broad.mit.edu	37	16	72821615	72821615	+	Silent	SNP	G	G	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr16:72821615G>A	ENST00000268489.5	-	10	11232	c.10560C>T	c.(10558-10560)ggC>ggT	p.G3520G	ZFHX3_ENST00000397992.5_Silent_p.G2606G|AC004943.1_ENST00000584072.1_RNA	NM_006885.3	NP_008816.3	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3	3520	Poly-Gly.				muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			NS(3)|breast(7)|cervix(2)|endometrium(18)|haematopoietic_and_lymphoid_tissue(5)|kidney(8)|large_intestine(22)|liver(1)|lung(46)|ovary(5)|pancreas(1)|prostate(15)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(11)	153		Ovarian(137;0.13)				cgccgccgccgccaccgccgc	0.706000													8	62					0	0	1	0	0
OR1E2	8388	broad.mit.edu	37	17	3336543	3336543	+	Missense_Mutation	SNP	C	C	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr17:3336543C>A	ENST00000248384.1	-	1	592	c.593G>T	c.(592-594)tGc>tTc	p.C198F		NM_003554.1	NP_003545.1	P47887	OR1E2_HUMAN	olfactory receptor, family 1, subfamily E, member 2	198					sensory perception of smell	integral to plasma membrane	olfactory receptor activity			endometrium(3)|large_intestine(3)|lung(3)	9						AGTGTCAGAGCAGGCCAGCTT	0.458000													7	252					6.31663e-08	6.75528e-08	1	1	0
RRN3P2	0	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													22	323					0	0	1	0	0
KDM5C	8242	broad.mit.edu	37	X	53231138	53231138	+	Silent	SNP	C	C	T	rs61733871	byFrequency	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chrX:53231138C>T	ENST00000452825.3	-	11	2095	c.1563G>A	c.(1561-1563)caG>caA	p.Q521Q	KDM5C_ENST00000375401.3_Silent_p.Q588Q|KDM5C_ENST00000375379.3_Silent_p.Q588Q|KDM5C_ENST00000465402.1_5'UTR|KDM5C_ENST00000375383.3_Silent_p.Q547Q|KDM5C_ENST00000404049.3_Silent_p.Q587Q	NM_001146702.1	NP_001140174.1	P41229	KDM5C_HUMAN	lysine (K)-specific demethylase 5C	588	JmjC.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			autonomic_ganglia(1)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(30)|large_intestine(9)|lung(17)|oesophagus(1)|ovary(6)|prostate(1)|salivary_gland(1)|skin(1)|upper_aerodigestive_tract(2)	82						CTCCTGCACACTGGTTTGTGC	0.483000			"""N, F, S"""		clear cell renal carcinoma								8	223					0	0	1	0	0
DPY19L2P2	0	broad.mit.edu	37	7	102883490	102883490	+	RNA	SNP	A	A	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr7:102883490A>C	ENST00000312132.4	-	0	2619																											CCAGTTCAGTACCACTGTAAA	0.303000													3	74					0	0	1	0	0
LINC00969	0	broad.mit.edu	37	3	195400728	195400728	+	RNA	SNP	A	A	G	rs12107841	by1000genomes	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:195400728A>G	ENST00000445430.1	+	0	1324																											GATTGTGCCCAGCCTGTACGC	0.587000													7	233					0	0	1	0	0
AC008103.5	0	broad.mit.edu	37	22	18844710	18844710	+	RNA	SNP	C	C	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr22:18844710C>A	ENST00000412938.1	+	0	2960																											AAAATTCCGACCATGGCAGAG	0.557000													7	51					8.12818e-05	8.57356e-05	1	1	0
ZSCAN5B	342933	broad.mit.edu	37	19	56701712	56701712	+	Silent	SNP	T	T	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:56701712T>C	ENST00000586855.2	-	5	1285	c.972A>G	c.(970-972)ccA>ccG	p.P324P	ZSCAN5B_ENST00000358992.3_Silent_p.P324P			A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	324					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|large_intestine(3)|lung(23)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						CAGCTTGTCCTGGGGATTCTC	0.567000													11	625					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414280	20414280	+	Silent	SNP	G	G	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr9:20414280G>A	ENST00000380338.4	-	5	850	c.564C>T	c.(562-564)agC>agT	p.S188S	MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S185S	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	188	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S188S(1)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		TGGTActactgctgctgctgc	0.502000			T	MLL	ALL								11	576					0	0	1	0	0
C5orf45	51149	broad.mit.edu	37	5	179271228	179271228	+	Splice_Site	SNP	C	C	T			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr5:179271228C>T	ENST00000518219.1	-	4	227		c.e4-1		C5orf45_ENST00000403396.2_Splice_Site|C5orf45_ENST00000376931.2_Intron|C5orf45_ENST00000292586.6_Splice_Site|C5orf45_ENST00000523084.1_Splice_Site|C5orf45_ENST00000520698.1_Intron|C5orf45_ENST00000518235.1_Splice_Site|C5orf45_ENST00000521333.1_Splice_Site			Q6NTE8	CE045_HUMAN	chromosome 5 open reading frame 45											breast(2)|endometrium(2)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)	12						TTCTAGAGACCTTCAGGGAAG	0.552000													8	321					0	0	1	0	0
MKL1	57591	broad.mit.edu	37	22	40820376	40820376	+	Missense_Mutation	SNP	A	A	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr22:40820376A>C	ENST00000396617.3	-	8	901	c.311T>G	c.(310-312)gTg>gGg	p.V104G	MKL1_ENST00000402042.1_Missense_Mutation_p.V104G|MKL1_ENST00000355630.3_Missense_Mutation_p.V104G|MKL1_ENST00000407029.1_Missense_Mutation_p.V104G			Q969V6	MKL1_HUMAN	megakaryoblastic leukemia (translocation) 1	104	Mediates interaction with SCAI and ACTB (By similarity).				positive regulation of transcription from RNA polymerase II promoter|smooth muscle cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	actin monomer binding|leucine zipper domain binding|nucleic acid binding|transcription coactivator activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(3)|lung(13)|ovary(4)|skin(1)|stomach(1)|urinary_tract(1)	30						GGGATAGTTCACCTGGCCCAC	0.592000			T	RBM15	acute megakaryocytic leukemia								8	198					0	0	1	0	0
TPTE2P6	0	broad.mit.edu	37	13	25161397	25161397	+	RNA	SNP	C	C	G	rs3874227	by1000genomes	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr13:25161397C>G	ENST00000453498.1	+	0	921																											TGAAACATCTCTACAACTGGA	0.343000													17	139					0	0	1	0	0
DAXX	1616	broad.mit.edu	37	6	33287900	33287900	+	Silent	SNP	C	C	T			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr6:33287900C>T	ENST00000374542.5	-	5	1557	c.1353G>A	c.(1351-1353)gaG>gaA	p.E451E	DAXX_ENST00000266000.6_Silent_p.E451E|DAXX_ENST00000414083.2_Silent_p.E376E|DAXX_ENST00000477162.1_5'UTR	NM_001141969.1|NM_001141970.1|NM_001350.4	NP_001135441.1|NP_001135442.1|NP_001341.1	Q9UER7	DAXX_HUMAN	death-domain associated protein	451	Asp/Glu-rich (acidic).|Necessary for interaction with USP7.				activation of JUN kinase activity|androgen receptor signaling pathway|apoptosis|induction of apoptosis via death domain receptors|interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|regulation of protein ubiquitination|transcription, DNA-dependent	chromosome, centromeric region|cytosol|nucleolus|PML body	androgen receptor binding|heat shock protein binding|p53 binding|protein homodimerization activity|protein N-terminus binding|receptor signaling protein activity|transcription factor binding|ubiquitin protein ligase binding	p.E451E(2)		breast(1)|central_nervous_system(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(5)|large_intestine(2)|lung(7)|ovary(3)|pancreas(18)|prostate(3)|skin(4)|upper_aerodigestive_tract(4)|urinary_tract(1)	55						cttcttcttcctcctcctcct	0.557000			"""Mis, F, N"""		Pancreatic neuroendocrine tumors. Paediatric GBM								5	205					0	0	1	0	0
HMGB3	3149	broad.mit.edu	37	X	150156360	150156360	+	Silent	SNP	G	G	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chrX:150156360G>A	ENST00000325307.7	+	5	672	c.576G>A	c.(574-576)gaG>gaA	p.E192E	HMGB3_ENST00000448905.2_Silent_p.E192E	NM_005342.2	NP_005333.2	O15347	HMGB3_HUMAN	high mobility group box 3	192	Asp/Glu-rich (acidic).				DNA recombination|multicellular organismal development	chromosome|nucleus	DNA bending activity|double-stranded DNA binding	p.E192E(1)		endometrium(3)|large_intestine(2)|lung(2)|skin(1)	8	Acute lymphoblastic leukemia(192;6.56e-05)					aggaagaagaggaggaggagg	0.443000													7	176					0	0	1	0	0
hsa-mir-7162	0	broad.mit.edu	37	15	62539781	62539781	+	RNA	SNP	A	A	G	rs2611797	by1000genomes	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr15:62539781A>G	ENST00000570077.1	-	0	170																											GCTGGTTAGCATCAGGGGCTT	0.537000													6	123					0	0	1	0	0
AES	166	broad.mit.edu	37	19	3053928	3053928	+	Silent	SNP	G	G	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:3053928G>A	ENST00000221561.8	-	7	863	c.684C>T	c.(682-684)acC>acT	p.T228T	AES_ENST00000586839.1_Silent_p.T105T|AES_ENST00000592330.1_Intron|AES_ENST00000327141.4_Silent_p.T161T	NM_198969.1	NP_945320.1	Q08117	AES_HUMAN	amino-terminal enhancer of split	161					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of response to cytokine stimulus|negative regulation of transcription from RNA polymerase II promoter|organ morphogenesis|response to interleukin-1|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity			lung(8)	8		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGAGGAGGCCGGTGCCTGCGC	0.687000													4	136					0	0	1	0	0
RAPH1	65059	broad.mit.edu	37	2	204305987	204305987	+	Silent	SNP	T	T	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr2:204305987T>G	ENST00000319170.5	-	14	2225	c.1926A>C	c.(1924-1926)ccA>ccC	p.P642P	RAPH1_ENST00000457812.1_Intron|RAPH1_ENST00000374493.3_Silent_p.P694P	NM_213589.1	NP_998754.1	Q70E73	RAPH1_HUMAN	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	642					cell-matrix adhesion|signal transduction	cytoplasm|cytoskeleton|filopodium|lamellipodium|nucleus|plasma membrane				breast(5)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						gagggggtggtggagggggtg	0.602000													6	67					0	0	1	0	0
TNK1	8711	broad.mit.edu	37	17	7287071	7287071	+	Missense_Mutation	SNP	C	C	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr17:7287071C>A	ENST00000570896.1	+	6	916	c.470C>A	c.(469-471)cCg>cAg	p.P157Q	TNK1_ENST00000311668.2_Missense_Mutation_p.P157Q|TNK1_ENST00000576812.1_Missense_Mutation_p.P157Q			Q13470	TNK1_HUMAN	tyrosine kinase, non-receptor, 1	157	Protein kinase.				protein autophosphorylation	membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(4)|lung(2)|pancreas(1)	16		Prostate(122;0.157)				CCCGAAGGCCCGATGGGCACA	0.627000													3	79					0.00909568	0.00921536	1	1	0
SLC6A10P	0	broad.mit.edu	37	16	32890639	32890639	+	RNA	SNP	T	T	C	rs79284655		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr16:32890639T>C	ENST00000330048.5	-	0	3159					NR_003083.2																						ACCAGCGGCTTGTAGTACACA	0.627000													18	190					0	0	1	0	0
THAP7-AS1	0	broad.mit.edu	37	22	21363392	21363392	+	RNA	SNP	G	G	A	rs28522842	by1000genomes	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr22:21363392G>A	ENST00000452284.1	+	0	1059				THAP7-AS1_ENST00000436079.1_RNA|TUBA3FP_ENST00000422086.1_RNA	NR_027051.1																						GGGCCCCATCGAATCACAGGG	0.562000													9	301					0	0	1	0	0
FAM86DP	0	broad.mit.edu	37	3	75476754	75476754	+	RNA	SNP	C	C	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:75476754C>G	ENST00000459803.1	-	0	602					NR_024241.1																						CCGGCTGTGACAGTCACTGAA	0.597000													5	199					0	0	1	0	0
ZNF131	7690	broad.mit.edu	37	5	43161998	43161998	+	Missense_Mutation	SNP	T	T	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr5:43161998T>C	ENST00000509634.1	+	5	1373	c.917T>C	c.(916-918)tTt>tCt	p.F306S	ZNF131_ENST00000306938.4_Missense_Mutation_p.F306S|ZNF131_ENST00000399534.1_Missense_Mutation_p.F340S|ZNF131_ENST00000505606.2_Missense_Mutation_p.F306S|ZNF131_ENST00000509156.1_Missense_Mutation_p.F340S|ZNF131_ENST00000509931.1_Intron			P52739	ZN131_HUMAN	zinc finger protein 131	340						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(2)|kidney(1)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	17						TTTGACCATTTTGGACATTTT	0.318000													7	270					0	0	1	0	0
GTF3C3	9330	broad.mit.edu	37	2	197657782	197657782	+	Silent	SNP	C	C	T			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr2:197657782C>T	ENST00000263956.3	-	3	398	c.309G>A	c.(307-309)gaG>gaA	p.E103E	GTF3C3_ENST00000409364.3_Silent_p.E103E	NM_012086.4	NP_036218.1	Q9Y5Q9	TF3C3_HUMAN	general transcription factor IIIC, polypeptide 3, 102kDa	103	Glu-rich.					transcription factor TFIIIC complex	DNA binding|protein binding	p.E103E(1)		breast(4)|endometrium(3)|kidney(1)|large_intestine(9)|lung(5)|ovary(3)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	33						cctcctcctcctcttcttcct	0.468000													6	244					0	0	1	0	0
LL22NC03-80A10.6	0	broad.mit.edu	37	22	22664056	22664056	+	RNA	SNP	T	T	C	rs3178309		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr22:22664056T>C	ENST00000426066.1	+	0	623					NR_027293.1																						ATAAAGTATATGATTTTGTGT	0.348000													7	243					0	0	1	0	0
RP11-423O2.5	0	broad.mit.edu	37	1	142803673	142803673	+	RNA	SNP	C	C	T			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:142803673C>T	ENST00000423385.1	-	0	1292																											atgttctatgcatttatcatc	0.303000													16	173					0	0	1	0	0
SPZ1	84654	broad.mit.edu	37	5	79616605	79616605	+	Missense_Mutation	SNP	C	C	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr5:79616605C>G	ENST00000296739.4	+	1	816	c.571C>G	c.(571-573)Cag>Gag	p.Q191E		NM_032567.3	NP_115956.3	Q9BXG8	SPZ1_HUMAN	spermatogenic leucine zipper 1	191					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			endometrium(2)|kidney(5)|large_intestine(4)|lung(12)|ovary(1)|skin(2)	26		Lung NSC(167;0.0393)|all_lung(232;0.0428)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;3.43e-47)|Epithelial(54;2.25e-41)|all cancers(79;4.19e-36)		AAAGAAACAGCAGATGATAAT	0.353000													9	424					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414346	20414346	+	Silent	SNP	G	G	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr9:20414346G>A	ENST00000380338.4	-	5	784	c.498C>T	c.(496-498)agC>agT	p.S166S	MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S163S	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	166	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S166S(4)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctactgctgctgctgc	0.527000			T	MLL	ALL								10	241					0	0	1	0	0
MANBA	4126	broad.mit.edu	37	4	103592551	103592551	+	Missense_Mutation	SNP	G	G	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr4:103592551G>A	ENST00000226578.4	-	9	1216	c.1117C>T	c.(1117-1119)Cgg>Tgg	p.R373W	MANBA_ENST00000505239.1_Missense_Mutation_p.R316W	NM_005908.3	NP_005899.3	O00462	MANBA_HUMAN	mannosidase, beta A, lysosomal	373					carbohydrate metabolic process|protein modification process	lysosome	beta-mannosidase activity|cation binding			cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(12)|ovary(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	42		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;4.44e-08)		AAAAGGAGCCGTAACCTGTAG	0.348000													5	125					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414340	20414340	+	Silent	SNP	G	G	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr9:20414340G>A	ENST00000380338.4	-	5	790	c.504C>T	c.(502-504)agC>agT	p.S168S	MLLT3_ENST00000475957.1_5'UTR|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000429426.2_Silent_p.S165S	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	168	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S168S(5)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.537000			T	MLL	ALL								18	256					0	0	1	0	0
SCNN1D	6339	broad.mit.edu	37	1	1222261	1222262	+	Frame_Shift_Ins	INS	-	-	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:1222261_1222262insC	ENST00000338555.2	+	5	1677_1678	c.533_534insC	c.(532-534)gccfs	p.A178fs	SCNN1D_ENST00000400928.3_Frame_Shift_Ins_p.A178fs|SCNN1D_ENST00000325425.8_Frame_Shift_Ins_p.A244fs|SCNN1D_ENST00000379116.5_Frame_Shift_Ins_p.A342fs					sodium channel, non-voltage-gated 1, delta subunit											lung(6)|skin(1)	7	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;2.46e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.199)		TCCGCCACTGTCCCCCGCCACG	0.644													9	382	---	---	---	---					
NADK	65220	broad.mit.edu	37	1	1688592	1688594	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:1688592_1688594delAGG	ENST00000344463.4	-	6	952_954	c.731_733delCCT	c.(730-735)ggg>g	p.AW244del	NADK_ENST00000378625.1_In_Frame_Del_p.AW244del|NADK_ENST00000492768.1_Intron|NADK_ENST00000341991.3_Intron|NADK_ENST00000341426.5_Intron|NADK_ENST00000342348.5_Intron			O95544	NADK_HUMAN	NAD kinase	131					ATP metabolic process|NAD metabolic process|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|NAD+ kinase activity|protein binding			NS(1)|autonomic_ganglia(1)|endometrium(4)|large_intestine(2)|lung(4)|ovary(1)|prostate(2)|stomach(1)|urinary_tract(1)	17	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.61e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;8.75e-37)|OV - Ovarian serous cystadenocarcinoma(86;2.33e-23)|GBM - Glioblastoma multiforme(42;1.35e-07)|Colorectal(212;0.000203)|COAD - Colon adenocarcinoma(227;0.000225)|Kidney(185;0.00265)|STAD - Stomach adenocarcinoma(132;0.00655)|BRCA - Breast invasive adenocarcinoma(365;0.00855)|KIRC - Kidney renal clear cell carcinoma(229;0.0382)|Lung(427;0.207)		TGTGCACCCCAGGCCCCCTTCCC	0.626													18	116	---	---	---	---					
VAMP3	9341	broad.mit.edu	37	1	7838212	7838214	+	In_Frame_Del	DEL	TCA	TCA	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:7838212_7838214delTCA	ENST00000054666.6	+	4	381_383	c.266_268delTCA	c.(265-270)ttc>t	p.FI89del	VAMP3_ENST00000470357.1_In_Frame_Del_p.FI61del	NM_004781.3	NP_004772.1	Q15836	VAMP3_HUMAN	vesicle-associated membrane protein 3	89					cellular membrane fusion|positive regulation of receptor recycling|protein complex assembly|protein transport|retrograde transport, endosome to Golgi|substrate adhesion-dependent cell spreading|vesicle docking involved in exocytosis	cell junction|clathrin-coated vesicle|integral to membrane|recycling endosome|synapse|synaptosome	protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)	6	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;6.33e-69)|GBM - Glioblastoma multiforme(8;2.07e-34)|Colorectal(212;1.36e-07)|COAD - Colon adenocarcinoma(227;1.38e-05)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000805)|KIRC - Kidney renal clear cell carcinoma(229;0.000917)|STAD - Stomach adenocarcinoma(132;0.000985)|READ - Rectum adenocarcinoma(331;0.0642)		CTGGTTATCTTCATCATCATCAT	0.365													13	1316	---	---	---	---					
PHACTR4	65979	broad.mit.edu	37	1	28800272	28800273	+	Frame_Shift_Ins	INS	-	-	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:28800272_28800273insC	ENST00000373839.3	+	7	1291_1292	c.1030_1031insC	c.(1030-1032)cccfs	p.P344fs	PHACTR4_ENST00000493669.1_3'UTR|PHACTR4_ENST00000373836.3_Frame_Shift_Ins_p.P354fs	NM_001048183.1	NP_001041648.1	Q8IZ21	PHAR4_HUMAN	phosphatase and actin regulator 4	344	Pro-rich.						actin binding|protein phosphatase inhibitor activity	p.P356fs*33(1)		NS(1)|biliary_tract(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(6)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	32		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)		TCGCTCTCCGTCCCCCCCACTG	0.515													10	1233	---	---	---	---					
SRSF4	6429	broad.mit.edu	37	1	29475219	29475221	+	In_Frame_Del	DEL	CTT	CTT	-	rs138237342	by1000genomes	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:29475219_29475221delCTT	ENST00000373795.4	-	6	1420_1422	c.1186_1188delAAG	c.(1186-1188)del	p.K396del	SRSF4_ENST00000466448.1_5'UTR|SRSF4_ENST00000546138.1_3'UTR	NM_005626.4	NP_005617.2	Q08170	SRSF4_HUMAN	serine/arginine-rich splicing factor 4	396	Arg/Ser-rich (RS domain).				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	nuclear speck	nucleotide binding|RNA binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(8)|liver(1)|lung(8)|ovary(1)|prostate(1)	27						CAGTGTCTTCCTTCTTCTTCTTC	0.601													26	651	---	---	---	---					
CCDC28B	79140	broad.mit.edu	37	1	32670247	32670248	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:32670247_32670248delTG	ENST00000421922.2	+	5	674_675	c.574_575delTG	c.(574-576)tfs	p.C192fs	CCDC28B_ENST00000483009.1_Intron|CCDC28B_ENST00000373602.5_Intron			Q9BUN5	CC28B_HUMAN	coiled-coil domain containing 28B	0										large_intestine(4)|lung(3)|ovary(1)|upper_aerodigestive_tract(2)	10		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				AACCCGTCTATGTGTGTGTGTT	0.500													7	994	---	---	---	---					
AGL	178	broad.mit.edu	37	1	100378028	100378028	+	Frame_Shift_Del	DEL	A	A	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:100378028delA	ENST00000294724.4	+	29	4382	c.3904delA	c.(3904-3906)aafs	p.K1303fs	AGL_ENST00000361522.4_Frame_Shift_Del_p.K1286fs|AGL_ENST00000370161.2_Frame_Shift_Del_p.K1287fs|AGL_ENST00000361915.3_Frame_Shift_Del_p.K1303fs|AGL_ENST00000361302.3_Frame_Shift_Del_p.K1287fs|AGL_ENST00000370163.3_Frame_Shift_Del_p.K1303fs|AGL_ENST00000370165.3_Frame_Shift_Del_p.K1303fs	NM_000028.2	NP_000019.2	P35573	GDE_HUMAN	amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase	1303					glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(9)|lung(35)|ovary(1)|prostate(4)|skin(3)|urinary_tract(1)	69		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		GGAATTATCCAAAAAAAATAT	0.323													12	440	---	---	---	---					
HIAT1	64645	broad.mit.edu	37	1	100534122	100534122	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:100534122delT	ENST00000370152.3	+	7	935	c.799delT	c.(799-801)ttfs	p.F268fs	RP4-714D9.2_ENST00000432294.1_RNA	NM_033055.2	NP_149044.2	Q96MC6	HIAT1_HUMAN	hippocampus abundant transcript 1	268					transmembrane transport	integral to membrane|plasma membrane	transporter activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(8)|skin(1)	16		all_epithelial(167;2.96e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0832)|all cancers(265;0.136)|COAD - Colon adenocarcinoma(174;0.148)|Lung(183;0.195)		ATATTCCAGCTTTTTTTTATA	0.388													8	600	---	---	---	---					
AP4B1	10717	broad.mit.edu	37	1	114438939	114438939	+	Frame_Shift_Del	DEL	A	A	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:114438939delA	ENST00000369569.1	-	8	1731	c.1451delT	c.(1450-1452)tcfs	p.F484fs	AP4B1_ENST00000462591.1_5'UTR|AP4B1_ENST00000256658.4_Frame_Shift_Del_p.F484fs|AP4B1-AS1_ENST00000419536.1_RNA|AP4B1_ENST00000369567.1_Frame_Shift_Del_p.F316fs	NM_001253852.1	NP_001240781.1	Q9Y6B7	AP4B1_HUMAN	adaptor-related protein complex 4, beta 1 subunit	484					intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|soluble fraction|trans-Golgi network	protein binding|protein transporter activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(9)|ovary(3)|prostate(3)	25	Lung SC(450;0.184)	all_cancers(81;4.5e-08)|all_epithelial(167;1.1e-07)|all_lung(203;1.53e-05)|Lung NSC(69;2.76e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCGGGAGAGGAAAAGGCGCAG	0.458													7	768	---	---	---	---					
HFE2	148738	broad.mit.edu	37	1	145415369	145415371	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:145415369_145415371delGAG	ENST00000336751.5	+	3	426_428	c.188_190delGAG	c.(187-192)cga>c	p.RG63del	HFE2_ENST00000497365.1_Intron|HFE2_ENST00000475797.1_Intron|HFE2_ENST00000357836.5_5'UTR	NM_213653.3	NP_998818.1	Q6ZVN8	RGMC_HUMAN	hemochromatosis type 2 (juvenile)	63					axon guidance	anchored to membrane				central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(7)|ovary(1)|pancreas(1)	14	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GGAGCACTTCGAGGAGGAGGAGG	0.626													12	473	---	---	---	---					
POLR3GL	84265	broad.mit.edu	37	1	145457040	145457042	+	In_Frame_Del	DEL	TCT	TCT	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:145457040_145457042delTCT	ENST00000369314.1	-	7	625_627	c.519_521delAGA	c.(517-522)gag>ga	p.EE173del	POLR3GL_ENST00000369313.3_In_Frame_Del_p.EE150del	NM_032305.1	NP_115681.1	Q9BT43	RPC7L_HUMAN	polymerase (RNA) III (DNA directed) polypeptide G (32kD)-like	173	Glu-rich.									endometrium(2)|large_intestine(1)|lung(1)	4	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					ctcttccttctcttcttcttctt	0.448													7	135	---	---	---	---					
FLAD1	80308	broad.mit.edu	37	1	154962050	154962050	+	Frame_Shift_Del	DEL	A	A	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:154962050delA	ENST00000368433.1	+	3	1475	c.1132delA	c.(1132-1134)aafs	p.K379fs	FLAD1_ENST00000405236.2_Intron|FLAD1_ENST00000368432.1_Frame_Shift_Del_p.K282fs|FLAD1_ENST00000292180.3_Frame_Shift_Del_p.K379fs|FLAD1_ENST00000315144.10_Frame_Shift_Del_p.K282fs|FLAD1_ENST00000295530.2_Intron|FLAD1_ENST00000368428.1_5'UTR			Q8NFF5	FAD1_HUMAN	flavin adenine dinucleotide synthetase 1	379					FAD biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|FMN adenylyltransferase activity	p.K378E(3)		endometrium(3)|kidney(4)|large_intestine(2)|lung(7)|ovary(3)|skin(3)	22	all_epithelial(22;2.77e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TTCTTTGGGGAAAAAGGTGGC	0.567													7	698	---	---	---	---					
KIAA0907	22889	broad.mit.edu	37	1	155886422	155886423	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:155886422_155886423delCT	ENST00000368320.3	-	12	1571_1572	c.1546_1547delAG	c.(1546-1548)gfs	p.R516fs	KIAA0907_ENST00000368321.3_Frame_Shift_Del_p.R516fs			Q7Z7F0	K0907_HUMAN	KIAA0907	516								p.R516fs*21(1)		breast(1)|endometrium(2)|kidney(1)|large_intestine(4)|liver(1)|lung(11)|urinary_tract(1)	21	Hepatocellular(266;0.133)|all_hematologic(923;0.145)|all_neural(408;0.195)		OV - Ovarian serous cystadenocarcinoma(3;8.82e-06)			TTACCTGTCCCTCTCTCTCTCT	0.396													43	1024	---	---	---	---					
NOS1AP	9722	broad.mit.edu	37	1	162326888	162326890	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:162326888_162326890delCAG	ENST00000361897.5	+	8	1303_1305	c.901_903delCAG	c.(901-903)del	p.Q306del	NOS1AP_ENST00000530878.1_In_Frame_Del_p.Q301del	NM_001164757.1|NM_014697.2	NP_001158229.1|NP_055512.1	O75052	CAPON_HUMAN	nitric oxide synthase 1 (neuronal) adaptor protein	306	Poly-Gln.				regulation of apoptosis|regulation of nitric oxide biosynthetic process|regulation of nitric-oxide synthase activity		nitric-oxide synthase binding|PDZ domain binding			NS(1)|breast(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(7)|lung(12)|skin(1)|upper_aerodigestive_tract(2)	32	all_hematologic(112;0.203)		BRCA - Breast invasive adenocarcinoma(70;0.0537)			gcagctcctccagcagcAGCAGC	0.611													11	262	---	---	---	---					
APOBEC4	403314	broad.mit.edu	37	1	183616826	183616828	+	In_Frame_Del	DEL	TTC	TTC	-	rs141411396		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:183616826_183616828delTTC	ENST00000308641.4	-	2	1360_1362	c.1089_1091delGAA	c.(1087-1092)aaa>aa	p.KK363del	RGL1_ENST00000536277.1_Intron|RGL1_ENST00000367531.1_Intron|RGL1_ENST00000304685.3_Intron|APOBEC4_ENST00000481562.1_5'UTR	NM_203454.2	NP_982279.1	Q8WW27	ABEC4_HUMAN	apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative)	363					mRNA processing		hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines|zinc ion binding			NS(1)|breast(3)|endometrium(3)|kidney(3)|large_intestine(4)|lung(6)|skin(1)	21						TTTCTTCCCTTTCTTCTTCTTCT	0.419													8	804	---	---	---	---					
TGFB2	7042	broad.mit.edu	37	1	218609370	218609371	+	Frame_Shift_Ins	INS	-	-	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:218609370_218609371insA	ENST00000366929.4	+	6	1364_1365	c.897_898insA	c.(895-900)agaaaafs	p.RK299fs	TGFB2_ENST00000479322.1_3'UTR|TGFB2_ENST00000366930.4_Frame_Shift_Ins_p.RK271fs	NM_001135599.2	NP_001129071.1	P61812	TGFB2_HUMAN	transforming growth factor, beta 2	271					activation of protein kinase activity|angiogenesis|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cardioblast differentiation|catagen|cell cycle arrest|cell death|cell growth|cell-cell junction organization|cell-cell signaling|collagen fibril organization|dopamine biosynthetic process|embryonic digestive tract development|eye development|glial cell migration|hair follicle morphogenesis|hemopoiesis|menstrual cycle phase|negative regulation of alkaline phosphatase activity|negative regulation of cell growth|negative regulation of epithelial cell proliferation|negative regulation of immune response|negative regulation of macrophage cytokine production|neuron development|neutrophil chemotaxis|odontogenesis|pathway-restricted SMAD protein phosphorylation|platelet activation|platelet degranulation|positive regulation of cardioblast differentiation|positive regulation of catagen|positive regulation of cell adhesion mediated by integrin|positive regulation of cell cycle|positive regulation of cell division|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of epithelial cell migration|positive regulation of epithelial to mesenchymal transition|positive regulation of heart contraction|positive regulation of immune response|positive regulation of integrin biosynthetic process|positive regulation of neuron apoptosis|positive regulation of ossification|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein secretion|positive regulation of stress-activated MAPK cascade|regulation of transforming growth factor-beta2 production|response to hypoxia|response to progesterone stimulus|salivary gland morphogenesis|SMAD protein import into nucleus|somatic stem cell division|transforming growth factor beta receptor signaling pathway	axon|extracellular matrix|extracellular space|neuronal cell body|platelet alpha granule lumen	beta-amyloid binding|cytokine activity|growth factor activity|protein heterodimerization activity|protein homodimerization activity|receptor signaling protein serine/threonine kinase activity|type II transforming growth factor beta receptor binding			breast(1)|endometrium(1)|large_intestine(11)|lung(15)|upper_aerodigestive_tract(2)|urinary_tract(1)	31				all cancers(67;0.0459)|OV - Ovarian serous cystadenocarcinoma(81;0.049)|GBM - Glioblastoma multiforme(131;0.0776)		AGTCCACTAGGAAAAAAAACAG	0.431													7	352	---	---	---	---					
MTR	4548	broad.mit.edu	37	1	237024474	237024474	+	Frame_Shift_Del	DEL	A	A	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:237024474delA	ENST00000366577.5	+	20	2487	c.2093delA	c.(2092-2094)cafs	p.Q698fs	MTR_ENST00000535889.1_Intron	NM_000254.2	NP_000245.2	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine methyltransferase	698	B12-binding N-terminal.				nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			breast(4)|central_nervous_system(1)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(30)|ovary(1)|pancreas(1)|prostate(2)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	67	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	AGGTTAAACCAAAAAAAATAT	0.308													10	382	---	---	---	---					
FMN2	56776	broad.mit.edu	37	1	240371335	240371337	+	In_Frame_Del	DEL	CCC	CCC	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr1:240371335_240371337delCCC	ENST00000319653.9	+	5	3453_3455	c.3223_3225delCCC	c.(3223-3225)del	p.P1079del		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1079	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			AGCGGGCATACCCCCTCCGCCCC	0.729													9	158	---	---	---	---					
ASXL2	55252	broad.mit.edu	37	2	26022304	26022306	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr2:26022304_26022306delCTG	ENST00000435504.4	-	5	644_646	c.351_353delCAG	c.(349-354)agt>ag	p.SS117del	ASXL2_ENST00000497092.1_5'UTR|ASXL2_ENST00000272341.4_5'UTR|ASXL2_ENST00000336112.4_In_Frame_Del_p.SS89del			Q76L83	ASXL2_HUMAN	additional sex combs like 2 (Drosophila)	117	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			NS(1)|breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(4)|lung(7)|pancreas(1)|prostate(4)|skin(3)|urinary_tract(3)	33	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCCACCATCACTGCTGCTGCTGC	0.463													17	784	---	---	---	---					
GPR113	165082	broad.mit.edu	37	2	26534413	26534413	+	Frame_Shift_Del	DEL	C	C	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr2:26534413delC	ENST00000333478.6	-	8	2168	c.1586delG	c.(1585-1587)gtfs	p.G529fs	GPR113_ENST00000311519.1_Frame_Shift_Del_p.G728fs|GPR113_ENST00000459892.1_5'UTR|GPR113_ENST00000541401.1_Frame_Shift_Del_p.G331fs|GPR113_ENST00000421160.2_Frame_Shift_Del_p.G659fs	NM_153835.3	NP_722577.2	Q8IZF5	GP113_HUMAN	G protein-coupled receptor 113	728					neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity	p.G529fs*46(1)		NS(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(5)|ovary(4)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	24	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTTGGACCAACCCCCCCTGCC	0.612													7	523	---	---	---	---					
CEBPZ	10153	broad.mit.edu	37	2	37454908	37454908	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr2:37454908delT	ENST00000234170.5	-	2	1573	c.1428delA	c.(1426-1428)aafs	p.K476fs		NM_005760.2	NP_005751.2	Q03701	CEBPZ_HUMAN	CCAAT/enhancer binding protein (C/EBP), zeta	476					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding			breast(3)|endometrium(2)|large_intestine(7)|lung(12)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	28		all_hematologic(82;0.21)				ATTCAACATCTTTTTTTTTGA	0.368													11	263	---	---	---	---					
RMDN2	151393	broad.mit.edu	37	2	38178783	38178783	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr2:38178783delT	ENST00000407257.1	+	2	572	c.425delT	c.(424-426)atfs	p.I142fs	RMDN2_ENST00000234195.3_Frame_Shift_Del_p.I142fs|RMDN2_ENST00000417700.2_Intron|RMDN2-AS1_ENST00000414365.2_RNA|RMDN2_ENST00000406384.1_Intron|RMDN2_ENST00000402091.3_Frame_Shift_Del_p.I142fs|RMDN2_ENST00000354545.2_Intron					regulator of microtubule dynamics 2																		AAGAGTGCCATTTTTTTTGAT	0.333													8	453	---	---	---	---					
AC007092.1	0	broad.mit.edu	37	2	58688842	58688843	+	RNA	DEL	CT	CT	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr2:58688842_58688843delCT	ENST00000452840.1	+	0	127																											TCTCTGCTAGCTCTCTCTCTCT	0.465													10	212	---	---	---	---					
USP34	9736	broad.mit.edu	37	2	61575023	61575025	+	In_Frame_Del	DEL	TGG	TGG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr2:61575023_61575025delTGG	ENST00000398571.2	-	15	2341_2343	c.2265_2267delCCA	c.(2263-2268)cat>ca	p.HH759del		NM_014709.3	NP_055524.3	Q70CQ2	UBP34_HUMAN	ubiquitin specific peptidase 34	759					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			autonomic_ganglia(1)|breast(14)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(24)|lung(52)|ovary(8)|prostate(10)|skin(6)|urinary_tract(2)	138			Epithelial(17;0.229)			gtggtggtgatggtggtggtggt	0.389													10	407	---	---	---	---					
SNRNP27	11017	broad.mit.edu	37	2	70131463	70131463	+	Frame_Shift_Del	DEL	T	T	-	rs79372020		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr2:70131463delT	ENST00000409116.1	+	5	452	c.426delT	c.(424-426)gafs	p.D142fs	SNRNP27_ENST00000244227.3_3'UTR			Q8WVK2	SNR27_HUMAN	small nuclear ribonucleoprotein 27kDa (U4/U6.U5)	0					mRNA processing|RNA splicing	nucleus	nucleic acid binding			cervix(1)|endometrium(1)|kidney(2)|large_intestine(3)|lung(2)|prostate(1)|upper_aerodigestive_tract(1)	11						TGAAGGATGATTTTTTTTCCC	0.348													9	339	---	---	---	---					
REV1	51455	broad.mit.edu	37	2	100055102	100055102	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr2:100055102delT	ENST00000258428.3	-	6	1402	c.1174delA	c.(1174-1176)tgfs	p.M392fs	REV1_ENST00000465835.1_5'UTR|REV1_ENST00000393445.3_Frame_Shift_Del_p.M392fs	NM_001037872.1|NM_016316.2	NP_001032961.1|NP_057400.1	Q9UBZ9	REV1_HUMAN	REV1, polymerase (DNA directed)	392					DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			NS(1)|breast(1)|endometrium(2)|kidney(1)|large_intestine(14)|lung(12)|ovary(2)|prostate(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	39						CCTGTTTTCATTTTTTTTAAC	0.348								Direct reversal of damage					11	606	---	---	---	---					
COL5A2	1290	broad.mit.edu	37	2	189943835	189943836	+	Splice_Site	INS	-	-	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr2:189943835_189943836insA	ENST00000374866.3	-	15	1235		c.e15-2			NM_000393.3	NP_000384.2	P05997	CO5A2_HUMAN	collagen, type V, alpha 2						axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			NS(3)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(53)|ovary(3)|prostate(2)|skin(6)|urinary_tract(3)	95			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			AGCTTCACCCTAAAAAAAAATG	0.381													10	398	---	---	---	---					
TMEFF2	23671	broad.mit.edu	37	2	193059175	193059177	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr2:193059175_193059177delGCA	ENST00000409056.3	-	1	73_75	c.74_76delTGC	c.(73-78)ccc>c	p.LP25del	TMEFF2_ENST00000392314.1_In_Frame_Del_p.LP25del|TMEFF2_ENST00000272771.5_In_Frame_Del_p.LP25del			Q9UIK5	TEFF2_HUMAN	transmembrane protein with EGF-like and two follistatin-like domains 2	25						extracellular region|integral to membrane				breast(2)|cervix(1)|kidney(2)|large_intestine(4)|liver(1)|lung(12)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	27			OV - Ovarian serous cystadenocarcinoma(117;0.0835)			AGCATGACGGGCAGCAGCAGCAG	0.601													7	417	---	---	---	---					
ALS2CR11	151254	broad.mit.edu	37	2	202352352	202352352	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr2:202352352delT	ENST00000439140.1	-	16	5490	c.5446delA	c.(5446-5448)ttfs	p.I1816fs	ALS2CR11_ENST00000286195.3_Frame_Shift_Del_p.I619fs|ALS2CR11_ENST00000439802.1_3'UTR	NM_001168221.1	NP_001161693.1	Q53TS8	AL2SA_HUMAN	amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 11	619										NS(1)|breast(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(11)|ovary(1)|skin(5)|urinary_tract(3)	33						CCTCTTTTAATTTTTTTTGGC	0.323													13	429	---	---	---	---					
RAPH1	65059	broad.mit.edu	37	2	204322298	204322298	+	Frame_Shift_Del	DEL	T	T	-	rs2469953	byFrequency	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr2:204322298delT	ENST00000319170.5	-	8	1412	c.1113delA	c.(1111-1113)aafs	p.K371fs	RAPH1_ENST00000418114.1_Frame_Shift_Del_p.K371fs|RAPH1_ENST00000439222.1_Frame_Shift_Del_p.K396fs|RAPH1_ENST00000419464.1_Frame_Shift_Del_p.K371fs|RAPH1_ENST00000374488.2_Frame_Shift_Del_p.K396fs|RAPH1_ENST00000423104.1_Frame_Shift_Del_p.K398fs|RAPH1_ENST00000374493.3_Frame_Shift_Del_p.K423fs|RAPH1_ENST00000374489.2_Frame_Shift_Del_p.K398fs|RAPH1_ENST00000457812.1_Frame_Shift_Del_p.K371fs|RAPH1_ENST00000453034.1_Frame_Shift_Del_p.K423fs|RAPH1_ENST00000308091.4_Frame_Shift_Del_p.K423fs	NM_213589.1	NP_998754.1	Q70E73	RAPH1_HUMAN	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	371					cell-matrix adhesion|signal transduction	cytoplasm|cytoskeleton|filopodium|lamellipodium|nucleus|plasma membrane				breast(5)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	32						CAGCTGTTTCTTTTTTCCCCA	0.373													8	785	---	---	---	---					
TRPM8	79054	broad.mit.edu	37	2	234879010	234879010	+	Frame_Shift_Del	DEL	C	C	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr2:234879010delC	ENST00000324695.4	+	17	2335	c.2295delC	c.(2293-2295)cafs	p.H765fs	TRPM8_ENST00000433712.2_Intron	NM_024080.4	NP_076985.4	Q7Z2W7	TRPM8_HUMAN	transient receptor potential cation channel, subfamily M, member 8	765						integral to membrane				breast(5)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(15)|liver(2)|lung(27)|prostate(2)|skin(7)|stomach(2)	66		Breast(86;0.00205)|Renal(207;0.00694)|all_lung(227;0.0129)|Lung NSC(271;0.0408)|all_hematologic(139;0.0753)|Acute lymphoblastic leukemia(138;0.224)		Epithelial(121;1.19e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000139)|Lung(119;0.00758)|LUSC - Lung squamous cell carcinoma(224;0.0108)	Menthol(DB00825)	CGGTGCCACACCCCCCCGAGC	0.577													7	1845	---	---	---	---					
HHATL	57467	broad.mit.edu	37	3	42739670	42739672	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:42739670_42739672delGAA	ENST00000441594.1	-	6	916_918	c.655_657delTTC	c.(655-657)del	p.F219del	HHATL_ENST00000310417.5_In_Frame_Del_p.F219del	NM_020707.3	NP_065758.3	Q9HCP6	HHATL_HUMAN	hedgehog acyltransferase-like	219					negative regulation of N-terminal protein palmitoylation	endoplasmic reticulum membrane|integral to membrane|perinuclear region of cytoplasm				NS(1)|breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(3)|prostate(3)	19				KIRC - Kidney renal clear cell carcinoma(284;0.215)		TGATGGGCCCGAAGAAGAAGAAG	0.552													8	556	---	---	---	---					
CDC25A	993	broad.mit.edu	37	3	48200922	48200923	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:48200922_48200923delTC	ENST00000302506.3	-	14	1753_1754	c.1345_1346delGA	c.(1345-1347)tfs	p.D449fs	CDC25A_ENST00000351231.3_Frame_Shift_Del_p.D409fs	NM_001789.2	NP_001780.2	P30304	MPIP1_HUMAN	cell division cycle 25A	449	Rhodanese.				cell cycle checkpoint|cell division|cell proliferation|cellular response to UV|DNA replication|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle	cytosol|nucleoplasm	protein binding|protein tyrosine phosphatase activity			breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(9)|prostate(1)|skin(1)	20				BRCA - Breast invasive adenocarcinoma(193;0.000685)|KIRC - Kidney renal clear cell carcinoma(197;0.00596)|Kidney(197;0.00684)		ACCCAGGCGATCTCTCTCTCTC	0.515													8	441	---	---	---	---					
USP4	7375	broad.mit.edu	37	3	49321969	49321971	+	In_Frame_Del	DEL	TCT	TCT	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:49321969_49321971delTCT	ENST00000351842.4	-	17	2185_2187	c.2177_2179delAGA	c.(2176-2181)acc>a	p.KT726del	USP4_ENST00000265560.4_In_Frame_Del_p.KT773del	NM_199443.2	NP_955475.1	Q13107	UBP4_HUMAN	ubiquitin specific peptidase 4 (proto-oncogene)	773					negative regulation of protein ubiquitination|protein deubiquitination|protein localization at cell surface|regulation of protein stability|ubiquitin-dependent protein catabolic process	lysosome|nucleus	adenosine receptor binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(1)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|liver(1)|lung(10)|ovary(3)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	33		Ovarian(412;0.00308)|Myeloproliferative disorder(1037;0.0255)|Hepatocellular(537;0.121)		OV - Ovarian serous cystadenocarcinoma(275;4.74e-26)|Kidney(197;2.22e-07)|KIRC - Kidney renal clear cell carcinoma(197;5.14e-06)|BRCA - Breast invasive adenocarcinoma(193;9.46e-05)		GCCACTGTGGTCTTCTTCTTCTT	0.532													11	592	---	---	---	---					
CACNA1D	776	broad.mit.edu	37	3	53529193	53529195	+	Translation_Start_Site	DEL	GAT	GAT	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:53529193_53529195delGAT	ENST00000288139.3	+	0	118_120				CACNA1D_ENST00000350061.5_Start_Codon_Del|CACNA1D_ENST00000422281.2_Start_Codon_Del	NM_000720.2	NP_000711.1	Q01668	CAC1D_HUMAN	calcium channel, voltage-dependent, L type, alpha 1D subunit						axon guidance|energy reserve metabolic process|regulation of insulin secretion	voltage-gated calcium channel complex	voltage-gated calcium channel activity			breast(3)|central_nervous_system(9)|cervix(2)|endometrium(11)|kidney(7)|large_intestine(13)|liver(1)|lung(29)|ovary(6)|prostate(2)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	90				BRCA - Breast invasive adenocarcinoma(193;0.00029)|KIRC - Kidney renal clear cell carcinoma(284;0.0145)|Kidney(284;0.0175)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)	Verapamil(DB00661)	aatgttcgtGgatgatgatgatg	0.581													15	601	---	---	---	---					
MAGI1	9223	broad.mit.edu	37	3	65372850	65372851	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:65372850_65372851delTC	ENST00000330909.8	-	15	2466_2467	c.2467_2468delGA	c.(2467-2469)afs	p.E823fs	MAGI1_ENST00000483466.1_Frame_Shift_Del_p.E823fs|MAGI1_ENST00000497477.2_Intron|MAGI1_ENST00000402939.2_Intron	NM_015520.1	NP_056335.1	Q96QZ7	MAGI1_HUMAN	membrane associated guanylate kinase, WW and PDZ domain containing 1	823	PDZ 4.				cell adhesion|cell surface receptor linked signaling pathway|protein complex assembly	tight junction	ATP binding|protein C-terminus binding			breast(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|liver(1)|lung(21)|pancreas(1)|skin(5)	51		Lung NSC(201;0.0016)		BRCA - Breast invasive adenocarcinoma(55;0.00138)|KIRC - Kidney renal clear cell carcinoma(15;0.0988)|Kidney(15;0.133)		GGAATTGATTTCTCTCTCTCTC	0.401													19	428	---	---	---	---					
LRIG1	26018	broad.mit.edu	37	3	66436625	66436627	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:66436625_66436627delGCT	ENST00000383703.3	-	14	2242_2244	c.1639_1641delAGC	c.(1639-1641)del	p.S548del	SLC25A26_ENST00000536651.1_3'UTR|LRIG1_ENST00000273261.3_In_Frame_Del_p.S524del|LRIG1_ENST00000496559.2_5'UTR			Q96JA1	LRIG1_HUMAN	leucine-rich repeats and immunoglobulin-like domains 1	524	Ig-like C2-type 1.					integral to membrane				NS(2)|breast(2)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(7)|lung(12)|ovary(3)|prostate(1)|skin(4)|stomach(4)|urinary_tract(1)	42		Lung NSC(201;0.0101)		BRCA - Breast invasive adenocarcinoma(55;0.00047)		TCATGGGGGAGCTGCTGCTGCTG	0.547													11	1645	---	---	---	---					
VGLL3	389136	broad.mit.edu	37	3	87027857	87027859	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:87027857_87027859delCTC	ENST00000398399.2	-	2	583_585	c.220_222delGAG	c.(220-222)del	p.E74del	VGLL3_ENST00000383698.3_In_Frame_Del_p.E74del	NM_016206.2	NP_057290.2	A8MV65	VGLL3_HUMAN	vestigial like 3 (Drosophila)	74					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(11)	19	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		GCTGGtctttctcctcctcctcc	0.502													8	261	---	---	---	---					
DPPA4	55211	broad.mit.edu	37	3	109049606	109049606	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:109049606delT	ENST00000335658.6	-	5	498	c.444delA	c.(442-444)aafs	p.K148fs	DPPA4_ENST00000478791.1_5'UTR	NM_018189.3	NP_060659.3	Q7L190	DPPA4_HUMAN	developmental pluripotency associated 4	148						nucleus	protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(1)|lung(17)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	25						CCACCTTTAATTTTTTTTGCA	0.413													8	539	---	---	---	---					
KIAA2018	205717	broad.mit.edu	37	3	113380090	113380090	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:113380090delT	ENST00000316407.4	-	7	849	c.439delA	c.(439-441)ttfs	p.I148fs	KIAA2018_ENST00000478658.1_Frame_Shift_Del_p.I148fs|KIAA2018_ENST00000491165.1_Intron	NM_001009899.2	NP_001009899.2	Q68DE3	K2018_HUMAN	KIAA2018	148					regulation of transcription, DNA-dependent	membrane|nucleus	calcium ion binding|DNA binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity			NS(1)|breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|liver(1)|lung(30)|ovary(8)|skin(5)|upper_aerodigestive_tract(4)|urinary_tract(2)	80						TAAACAATAATTTTTTTTTGA	0.373													10	523	---	---	---	---					
TMCC1	23023	broad.mit.edu	37	3	129370576	129370578	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:129370576_129370578delCTG	ENST00000393238.3	-	6	2048_2050	c.1708_1710delCAG	c.(1708-1710)del	p.Q570del	TMCC1_ENST00000329333.5_In_Frame_Del_p.Q391del|TMCC1_ENST00000432054.2_In_Frame_Del_p.Q246del|TMCC1_ENST00000426664.2_In_Frame_Del_p.Q456del	NM_001017395.3	NP_001017395.2	O94876	TMCC1_HUMAN	transmembrane and coiled-coil domain family 1	570						integral to membrane			PLXND1/TMCC1(4)	breast(1)|endometrium(3)|large_intestine(8)|lung(12)|skin(1)	25						GCTGCACCACCTGCTGCTGCTGC	0.581													26	525	---	---	---	---					
TFDP2	7029	broad.mit.edu	37	3	141692946	141692947	+	Frame_Shift_Ins	INS	-	-	T			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:141692946_141692947insT	ENST00000499676.2	-	8	1097_1098	c.426_427insA	c.(424-429)aaaaatfs	p.N143fs	TFDP2_ENST00000477292.1_Frame_Shift_Ins_p.N67fs|TFDP2_ENST00000467072.1_Frame_Shift_Ins_p.N143fs|TFDP2_ENST00000495310.1_Frame_Shift_Ins_p.N106fs|TFDP2_ENST00000397991.4_Frame_Shift_Ins_p.N175fs|TFDP2_ENST00000310282.6_Frame_Shift_Ins_p.N143fs|TFDP2_ENST00000489671.1_Frame_Shift_Ins_p.N203fs|TFDP2_ENST00000317104.7_Frame_Shift_Ins_p.N127fs|TFDP2_ENST00000479040.1_Frame_Shift_Ins_p.N142fs|TFDP2_ENST00000486111.1_Frame_Shift_Ins_p.N143fs	NM_001178139.1	NP_001171610.1	Q14188	TFDP2_HUMAN	transcription factor Dp-2 (E2F dimerization partner 2)	203					cell cycle	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|transcription factor binding			kidney(1)|upper_aerodigestive_tract(2)	3						CACTTGATTTCTTTTTTTTCCT	0.342													10	551	---	---	---	---					
MED12L	116931	broad.mit.edu	37	3	151148114	151148116	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:151148114_151148116delCAG	ENST00000474524.1	+	42	6369_6371	c.6331_6333delCAG	c.(6331-6333)del	p.Q2115del	MED12L_ENST00000273432.4_In_Frame_Del_p.Q1779del	NM_053002.4	NP_443728.3	Q86YW9	MD12L_HUMAN	mediator complex subunit 12-like	2115	Gln-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex		p.Q2111E(1)		NS(1)|breast(3)|central_nervous_system(3)|cervix(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(27)|lung(50)|ovary(6)|prostate(3)|skin(4)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	128			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			GCAGCAGACCCAGCAGCAGCAGC	0.527													12	482	---	---	---	---					
SEC62	7095	broad.mit.edu	37	3	169700663	169700664	+	Frame_Shift_Ins	INS	-	-	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:169700663_169700664insA	ENST00000337002.4	+	4	478_479	c.420_421insA	c.(418-423)gaaaaafs	p.EK140fs	SEC62_ENST00000480708.1_Frame_Shift_Ins_p.EK140fs|SEC62-AS1_ENST00000479626.1_RNA	NM_003262.3	NP_003253.1	Q99442	SEC62_HUMAN	SEC62 homolog (S. cerevisiae)	140					cotranslational protein targeting to membrane|transmembrane transport	aggresome|endoplasmic reticulum membrane|integral to membrane|intermediate filament cytoskeleton|rough endoplasmic reticulum	protein transporter activity|receptor activity			NS(1)|endometrium(1)|large_intestine(1)|lung(4)|ovary(1)|skin(1)	9						aagaaaaagagaaaaaaaaaga	0.277													10	115	---	---	---	---					
FXR1	0	broad.mit.edu	37	3	180666228	180666228	+	Frame_Shift_Del	DEL	A	A	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr3:180666228delA	ENST00000357559.4	+	5	748	c.364delA	c.(364-366)aafs	p.K123fs	FXR1_ENST00000468861.1_Frame_Shift_Del_p.K38fs|FXR1_ENST00000491062.1_Frame_Shift_Del_p.K74fs|FXR1_ENST00000445140.2_Frame_Shift_Del_p.K123fs|FXR1_ENST00000480918.1_Frame_Shift_Del_p.K110fs|FXR1_ENST00000305586.7_Frame_Shift_Del_p.K38fs	NM_001013438.2|NM_005087.3	NP_001013456.1|NP_005078.2	P51114	FXR1_HUMAN	fragile X mental retardation, autosomal homolog 1	123					apoptosis|cell differentiation|muscle organ development	nucleolus|polysome		p.N124fs*14(1)		breast(3)|endometrium(4)|large_intestine(5)|lung(12)|skin(2)	26	all_cancers(143;6.07e-14)|Ovarian(172;0.0212)		Epithelial(37;3.05e-35)|OV - Ovarian serous cystadenocarcinoma(80;2.4e-22)			TAAAACTGTCAAAAAAAATAC	0.333													9	362	---	---	---	---					
PDE6B	5158	broad.mit.edu	37	4	661763	661765	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr4:661763_661765delAGG	ENST00000255622.6	+	21	2514_2516	c.2471_2473delAGG	c.(2470-2475)aag>a	p.KE824del	PDE6B_ENST00000429163.2_In_Frame_Del_p.KE545del|PDE6B_ENST00000496514.1_In_Frame_Del_p.KE824del	NM_000283.3|NM_001145291.1	NP_000274.2|NP_001138763.1	P35913	PDE6B_HUMAN	phosphodiesterase 6B, cGMP-specific, rod, beta	824					cytosolic calcium ion homeostasis|GMP metabolic process|phototransduction, visible light|platelet activation|visual perception	cytosol|membrane	3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			NS(1)|breast(3)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|lung(11)|ovary(2)|prostate(2)|urinary_tract(1)	30						CTGGAGGAGAAGGAGGAGGAGGA	0.562													19	750	---	---	---	---					
FGFRL1	53834	broad.mit.edu	37	4	1019055	1019056	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr4:1019055_1019056delCA	ENST00000398484.2	+	8	2015_2016	c.1435_1436delCA	c.(1435-1437)cfs	p.H479fs	FGFRL1_ENST00000264748.6_Frame_Shift_Del_p.H479fs|FGFRL1_ENST00000504138.1_Frame_Shift_Del_p.H479fs|FGFRL1_ENST00000510644.1_Frame_Shift_Del_p.H479fs			Q8N441	FGRL1_HUMAN	fibroblast growth factor receptor-like 1	479	His-rich.				regulation of cell growth	integral to membrane|plasma membrane	fibroblast growth factor receptor activity|heparin binding			endometrium(1)|lung(9)|ovary(1)|prostate(1)|skin(1)	13			OV - Ovarian serous cystadenocarcinoma(23;0.0158)			cacagacatccacacacacaca	0.584													9	44	---	---	---	---					
PROM1	8842	broad.mit.edu	37	4	15995680	15995680	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr4:15995680delT	ENST00000505450.1	-	15	2282	c.1670delA	c.(1669-1671)atfs	p.N557fs	PROM1_ENST00000447510.2_Frame_Shift_Del_p.N566fs|PROM1_ENST00000508167.1_Frame_Shift_Del_p.N557fs|PROM1_ENST00000543373.1_Frame_Shift_Del_p.N557fs|PROM1_ENST00000540805.1_Frame_Shift_Del_p.N566fs|PROM1_ENST00000539194.1_Frame_Shift_Del_p.N566fs|PROM1_ENST00000510224.1_Frame_Shift_Del_p.N566fs	NM_001145848.1	NP_001139320.1	O43490	PROM1_HUMAN	prominin 1	566					camera-type eye photoreceptor cell differentiation|photoreceptor cell maintenance|retina layer formation	apical plasma membrane|cell surface|integral to plasma membrane|microvillus membrane|photoreceptor outer segment membrane|plasma membrane	beta-actinin binding|cadherin binding			breast(2)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|liver(1)|lung(11)|ovary(3)|pancreas(1)|upper_aerodigestive_tract(2)	35						AGTGCCTCTATTTTTTTTGCA	0.428													8	496	---	---	---	---					
GABRG1	2565	broad.mit.edu	37	4	46060358	46060358	+	Frame_Shift_Del	DEL	A	A	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr4:46060358delA	ENST00000295452.4	-	7	959	c.792delT	c.(790-792)ttfs	p.F264fs		NM_173536.3	NP_775807.2	Q8N1C3	GBRG1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, gamma 1	264					gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity	p.F264fs*3(1)		breast(2)|central_nervous_system(5)|endometrium(3)|kidney(4)|large_intestine(11)|liver(1)|lung(37)|ovary(2)|prostate(5)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	76				Lung(65;0.106)|LUSC - Lung squamous cell carcinoma(721;0.23)		TGCTCAGGTCAAAAAAAATTG	0.294													9	427	---	---	---	---					
ANTXR2	118429	broad.mit.edu	37	4	80905990	80905990	+	Frame_Shift_Del	DEL	C	C	-	rs12647691	by1000genomes	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr4:80905990delC	ENST00000403729.2	-	13	1594	c.1069delG	c.(1069-1071)ccfs	p.A357fs	ANTXR2_ENST00000404191.1_Frame_Shift_Del_p.A280fs|ANTXR2_ENST00000346652.6_Frame_Shift_Del_p.A254fs|ANTXR2_ENST00000307333.7_Frame_Shift_Del_p.A357fs	NM_058172.5	NP_477520.2	P58335	ANTR2_HUMAN	anthrax toxin receptor 2	357	Poly-Pro.		A -> P (in dbSNP:rs12647691).			endoplasmic reticulum membrane|extracellular region|integral to membrane|plasma membrane	metal ion binding|protein binding|receptor activity			endometrium(2)|kidney(1)|large_intestine(2)|lung(7)|ovary(1)	13						GGTGCAGGGGCGGGTGGTGGT	0.348									Juvenile Hyaline Fibromatosis				10	93	---	---	---	---					
ADAD1	132612	broad.mit.edu	37	4	123302211	123302211	+	Frame_Shift_Del	DEL	A	A	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr4:123302211delA	ENST00000296513.2	+	4	422	c.237delA	c.(235-237)ccfs	p.P79fs	ADAD1_ENST00000388725.2_Frame_Shift_Del_p.P61fs|ADAD1_ENST00000388724.2_Frame_Shift_Del_p.P79fs|ADAD1_ENST00000492454.1_3'UTR	NM_139243.3	NP_640336.1	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1 (testis-specific)	79					multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(18)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	35						TCCTTCCTCCAAAAAAAATAC	0.358													8	395	---	---	---	---					
HMGB2	3148	broad.mit.edu	37	4	174253277	174253279	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr4:174253277_174253279delTCC	ENST00000296503.5	-	5	1455_1457	c.582_584delGGA	c.(580-585)gaa>ga	p.EE196del	HMGB2_ENST00000438704.2_In_Frame_Del_p.EE196del|HMGB2_ENST00000446922.2_In_Frame_Del_p.EE196del			P26583	HMGB2_HUMAN	high mobility group box 2	196	Asp/Glu-rich (acidic).				base-excision repair, DNA ligation|cell chemotaxis|cellular response to lipopolysaccharide|DNA fragmentation involved in apoptotic nuclear change|DNA topological change|negative regulation of transcription, DNA-dependent|nucleosome assembly|phosphatidylinositol-mediated signaling|positive regulation of DNA binding|positive regulation of endothelial cell proliferation|positive regulation of erythrocyte differentiation|positive regulation of megakaryocyte differentiation|positive regulation of nuclease activity|positive regulation of transcription from RNA polymerase II promoter|V(D)J recombination	condensed chromosome|extracellular space|nucleolus|nucleoplasm|perinuclear region of cytoplasm|protein complex	chemoattractant activity|damaged DNA binding|DNA bending activity|double-stranded DNA binding|RAGE receptor binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding|transcription regulatory region DNA binding	p.E194E(1)		endometrium(2)|kidney(1)|large_intestine(2)|lung(6)|urinary_tract(3)	14		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;9.58e-18)|Epithelial(43;3.75e-16)|OV - Ovarian serous cystadenocarcinoma(60;6.24e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		atcttcttcttcctcctcctcct	0.468													8	496	---	---	---	---					
THBS4	7060	broad.mit.edu	37	5	79372774	79372776	+	In_Frame_Del	DEL	TGA	TGA	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr5:79372774_79372776delTGA	ENST00000350881.2	+	16	2179_2181	c.1989_1991delTGA	c.(1987-1992)tgt>tg	p.CD663del	THBS4_ENST00000511733.1_In_Frame_Del_p.CD572del|CTD-2201I18.1_ENST00000503007.1_RNA|CTD-2201I18.1_ENST00000514042.1_RNA	NM_003248.4	NP_003239.2	P35443	TSP4_HUMAN	thrombospondin 4	663					endothelial cell-cell adhesion|myoblast migration|negative regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of neutrophil chemotaxis|positive regulation of peptidyl-tyrosine phosphorylation	basement membrane|extracellular space	calcium ion binding|heparin binding|integrin binding|structural molecule activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(9)|lung(14)|ovary(1)|stomach(3)	34		Lung NSC(167;0.00328)|all_lung(232;0.00355)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-45)|Epithelial(54;1.77e-39)|all cancers(79;3.2e-34)		GTGACGAGTGTGATGATGATGAT	0.562													15	1355	---	---	---	---					
AP3S1	1176	broad.mit.edu	37	5	115202418	115202421	+	Frame_Shift_Del	DEL	AAGA	AAGA	-	rs80118146		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr5:115202418_115202421delAAGA	ENST00000316788.7	+	2	678_681	c.121_124delAAGA	c.(121-126)gafs	p.KR41fs		NM_001284.2	NP_001275.1	Q92572	AP3S1_HUMAN	adaptor-related protein complex 3, sigma 1 subunit	41					insulin receptor signaling pathway|intracellular protein transport|vesicle-mediated transport	AP-type membrane coat adaptor complex|cytoplasmic vesicle membrane|Golgi apparatus|transport vesicle	protein binding|protein transporter activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(2)|ovary(1)|pancreas(1)|prostate(1)	12		all_cancers(142;0.00377)|all_epithelial(76;0.000129)|Prostate(80;0.0132)|Ovarian(225;0.0776)|Lung NSC(810;0.245)		OV - Ovarian serous cystadenocarcinoma(64;1.08e-07)|Epithelial(69;1.11e-06)|all cancers(49;5.2e-05)		TTTGGTATCTAAGAGAGATGAAAA	0.304													14	320	---	---	---	---					
MEGF10	84466	broad.mit.edu	37	5	126792989	126792991	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr5:126792989_126792991delCAG	ENST00000274473.6	+	26	3669_3671	c.3402_3404delCAG	c.(3400-3405)aac>aa	p.NS1134del	MEGF10_ENST00000503335.2_In_Frame_Del_p.NS1134del	NM_032446.2	NP_115822.1	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10	1134	Necessary for formation of large intracellular vacuoles.|Ser-rich.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				breast(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(28)|ovary(4)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	68		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		gcagcagcaacagcagcagcagc	0.512													8	326	---	---	---	---					
CDC25C	995	broad.mit.edu	37	5	137627690	137627690	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr5:137627690delT	ENST00000323760.6	-	8	1009	c.731delA	c.(730-732)agfs	p.K244fs	CDC25C_ENST00000514555.1_Frame_Shift_Del_p.K214fs|CDC25C_ENST00000513970.1_Frame_Shift_Del_p.K244fs|CDC25C_ENST00000357274.3_Frame_Shift_Del_p.K201fs|CDC25C_ENST00000356505.3_Frame_Shift_Del_p.K214fs|CDC25C_ENST00000348983.3_Frame_Shift_Del_p.K171fs|CDC25C_ENST00000415130.2_Frame_Shift_Del_p.K171fs	NM_001790.3	NP_001781.2	P30307	MPIP3_HUMAN	cell division cycle 25C	244					cell cycle checkpoint|cell division|cell proliferation|DNA replication|G2/M transition of mitotic cell cycle|interspecies interaction between organisms|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of mitosis|traversing start control point of mitotic cell cycle	cytosol|nucleoplasm	protein tyrosine phosphatase activity|WW domain binding			endometrium(2)|kidney(3)|large_intestine(5)|lung(5)|skin(1)	16			KIRC - Kidney renal clear cell carcinoma(527;0.004)|Kidney(363;0.00592)			AGAAAAATACTTTTTTTTAAC	0.388													7	512	---	---	---	---					
HAVCR2	84868	broad.mit.edu	37	5	156535948	156535950	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr5:156535948_156535950delAGC	ENST00000307851.4	-	1	775_777	c.45_47delGCT	c.(43-48)cta>ct	p.LL17del	CTB-120L21.1_ENST00000517708.1_RNA|HAVCR2_ENST00000522593.1_In_Frame_Del_p.LL17del	NM_032782.4	NP_116171.3	Q8TDQ0	HAVR2_HUMAN	hepatitis A virus cellular receptor 2	17						integral to membrane		p.L18delL(1)|p.L15L(1)		cervix(1)|large_intestine(4)|lung(12)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	22	Renal(175;0.00212)	Medulloblastoma(196;0.0354)|all_neural(177;0.0999)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			TGTAAGTAGTAGCAGCAGCAGCA	0.438													7	350	---	---	---	---					
HMMR	3161	broad.mit.edu	37	5	162917425	162917426	+	Frame_Shift_Ins	INS	-	-	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr5:162917425_162917426insA	ENST00000416990.2	+	17	2144_2145	c.1647_1648insA	c.(1645-1650)gcaaaafs	p.AK549fs	HMMR_ENST00000393915.4_Frame_Shift_Ins_p.AK664fs|HMMR_ENST00000353866.3_Frame_Shift_Ins_p.AK648fs|HMMR_ENST00000358715.3_Frame_Shift_Ins_p.AK663fs|HMMR_ENST00000432118.2_Frame_Shift_Ins_p.AK577fs|RP11-80G7.1_ENST00000514724.2_RNA|RP11-80G7.1_ENST00000521666.1_RNA			O75330	HMMR_HUMAN	hyaluronan-mediated motility receptor (RHAMM)	663						cell surface|cytoplasm	hyaluronic acid binding			cervix(1)|kidney(3)|large_intestine(6)|lung(9)|pancreas(1)|prostate(1)|skin(1)|stomach(1)	23	Renal(175;0.000281)	Medulloblastoma(196;0.00853)|all_neural(177;0.0408)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0296)|OV - Ovarian serous cystadenocarcinoma(192;0.0423)|Epithelial(171;0.0848)		GTCAGCTTGCTAAAAAAAAACA	0.307													13	421	---	---	---	---					
CANX	821	broad.mit.edu	37	5	179149920	179149920	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr5:179149920delT	ENST00000247461.4	+	11	1498	c.1298delT	c.(1297-1299)atfs	p.I433fs	CANX_ENST00000512607.2_Frame_Shift_Del_p.I325fs|CANX_ENST00000415618.2_Frame_Shift_Del_p.I468fs|CANX_ENST00000452673.2_Frame_Shift_Del_p.I433fs|CANX_ENST00000504734.1_Frame_Shift_Del_p.I433fs	NM_001746.3	NP_001737.1	P27824	CALX_HUMAN	calnexin	433				SDI -> LTF (in Ref. 9; AAA35696).	post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine|protein secretion	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane|melanosome	calcium ion binding|sugar binding|unfolded protein binding			breast(1)|endometrium(3)|kidney(4)|large_intestine(2)|lung(7)|prostate(2)|urinary_tract(3)	22	all_cancers(89;0.000129)|all_epithelial(37;5.59e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0413)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)		Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Reteplase(DB00015)|Tenecteplase(DB00031)	ACCTCTGACATTTTTTTTGAC	0.423													8	512	---	---	---	---					
TRIM52	84851	broad.mit.edu	37	5	180687612	180687614	+	In_Frame_Del	DEL	TCC	TCC	-	rs146030758		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr5:180687612_180687614delTCC	ENST00000327767.4	-	1	505_507	c.201_203delGGA	c.(199-204)gac>ga	p.ED67del	TRIM52_ENST00000514805.1_5'UTR|CTC-338M12.4_ENST00000511331.1_RNA	NM_032765.2	NP_116154.1	Q96A61	TRI52_HUMAN	tripartite motif containing 52	67	Glu-rich.					intracellular	zinc ion binding			endometrium(1)|large_intestine(2)|lung(3)|skin(1)|stomach(1)	8	all_cancers(89;8.79e-06)|all_epithelial(37;1.13e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0654)	all_cancers(40;0.0106)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.0588)|all_lung(500;0.149)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.232)		CGCTtcctcgtcctcctcctcct	0.581													7	474	---	---	---	---					
BTN2A2	10385	broad.mit.edu	37	6	26384091	26384093	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr6:26384091_26384093delCCT	ENST00000356709.4	+	2	153_155	c.42_44delCCT	c.(40-45)tcc>tc	p.SL14del	BTN2A2_ENST00000469230.1_In_Frame_Del_p.SL14del|BTN2A2_ENST00000352867.2_In_Frame_Del_p.SL14del|BTN2A2_ENST00000432533.2_In_Frame_Del_p.SL14del|BTN2A2_ENST00000416795.2_In_Frame_Del_p.SL14del|BTN2A2_ENST00000482536.1_In_Frame_Del_p.SL14del	NM_001197240.1|NM_006995.4	NP_001184169.1|NP_008926.2	Q8WVV5	BT2A2_HUMAN	butyrophilin, subfamily 2, member A2	14					negative regulation of activated T cell proliferation|negative regulation of cellular metabolic process|negative regulation of cytokine secretion	integral to membrane				breast(2)|endometrium(3)|large_intestine(5)|lung(13)	23						TGCCAGCCTCcctcctcctcctc	0.581													12	481	---	---	---	---					
CDSN	1041	broad.mit.edu	37	6	31084620	31084622	+	In_Frame_Del	DEL	CCA	CCA	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr6:31084620_31084622delCCA	ENST00000376288.2	-	2	796_798	c.770_772delTGG	c.(769-774)gac>g	p.VD257del	PSORS1C1_ENST00000259881.9_Intron|PSORS1C1_ENST00000467107.1_3'UTR	NM_001264.4	NP_001255.3	Q15517	CDSN_HUMAN	corneodesmosin	257	Ser-rich.				cell-cell adhesion|keratinocyte differentiation|skin morphogenesis	cornified envelope|desmosome|extracellular region	protein homodimerization activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(3)|ovary(1)|pancreas(1)	10						CCGTGCTGGTCCACCACCACCAC	0.635													8	249	---	---	---	---					
TULP1	7287	broad.mit.edu	37	6	35478775	35478777	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr6:35478775_35478777delTCC	ENST00000229771.6	-	5	439_441	c.360_362delGGA	c.(358-363)gaa>ga	p.EE122del	TULP1_ENST00000322263.4_In_Frame_Del_p.EE69del	NM_003322.3	NP_003313.3	O00294	TULP1_HUMAN	tubby like protein 1	122	Poly-Glu.		Missing (in RP14).		dendrite development|eye photoreceptor cell development|phagocytosis|photoreceptor cell maintenance|positive regulation of phagocytosis	cell junction|cytoplasm|extracellular region|photoreceptor inner segment|photoreceptor outer segment|synapse	actin filament binding|phosphatidylinositol-4,5-bisphosphate binding			central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(5)|ovary(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	19						gtcctcctcttcctcctcctcct	0.567													7	617	---	---	---	---					
MDFI	4188	broad.mit.edu	37	6	41621169	41621171	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr6:41621169_41621171delCTG	ENST00000373050.4	+	4	601_603	c.414_416delCTG	c.(412-417)ctc>ct	p.LC138del				Q99750	MDFI_HUMAN	MyoD family inhibitor	199					cytoplasmic sequestering of transcription factor|dorsal/ventral axis specification|negative regulation of DNA binding|negative regulation of transcription from RNA polymerase II promoter|negative regulation of Wnt receptor signaling pathway	cytoplasm|nucleus				endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|liver(2)|prostate(2)|skin(1)|urinary_tract(1)	8	Ovarian(28;0.0327)|Colorectal(47;0.121)		Colorectal(64;0.0123)|COAD - Colon adenocarcinoma(64;0.0264)|KIRC - Kidney renal clear cell carcinoma(1;0.138)			ACTCGTGCCTCTGCTGCTGCTGC	0.655													17	547	---	---	---	---					
UBR2	23304	broad.mit.edu	37	6	42611951	42611951	+	Splice_Site	DEL	G	G	-	rs112519289		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr6:42611951delG	ENST00000372901.1	+	19	2355		c.e19-1		UBR2_ENST00000372883.3_Splice_Site|UBR2_ENST00000372899.1_Splice_Site			Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin 2						cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(10)|kidney(7)|large_intestine(14)|lung(22)|ovary(3)|pancreas(1)|skin(5)	64	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			AAAAAAAAAAGACAGGTGTCT	0.373													7	484	---	---	---	---					
ICK	22858	broad.mit.edu	37	6	52883129	52883129	+	Splice_Site	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr6:52883129delT	ENST00000356971.3	-	8	1151	c.663_splice	c.e8+1	p.K221_splice	ICK_ENST00000350082.5_Splice_Site_p.K221_splice	NM_016513.4	NP_057597.2	Q9UPZ9	ICK_HUMAN	intestinal cell (MAK-like) kinase	221	Protein kinase.				intracellular protein kinase cascade|multicellular organismal development	cytosol|nucleus	ATP binding|cyclin-dependent protein kinase activity|magnesium ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(3)|stomach(1)	31	Lung NSC(77;0.103)					TATCATTACCTTTTTTGGTGT	0.502													7	1290	---	---	---	---					
HCRTR2	3062	broad.mit.edu	37	6	55039411	55039411	+	Frame_Shift_Del	DEL	C	C	-	rs76774128		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr6:55039411delC	ENST00000370862.3	+	1	362	c.26delC	c.(25-27)tcfs	p.S9fs		NM_001526.3	NP_001517.2	O43614	OX2R_HUMAN	hypocretin (orexin) receptor 2	9					feeding behavior	integral to plasma membrane	neuropeptide receptor activity	p.P11fs*11(1)		breast(3)|endometrium(2)|kidney(1)|large_intestine(7)|lung(23)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	46	Lung NSC(77;0.107)|Renal(3;0.122)		LUSC - Lung squamous cell carcinoma(124;0.23)			TTGGAGGACTCCCCCCCTTGT	0.567													7	765	---	---	---	---					
C6orf165	154313	broad.mit.edu	37	6	88144700	88144700	+	Frame_Shift_Del	DEL	A	A	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr6:88144700delA	ENST00000507897.1	+	11	1506	c.1423delA	c.(1423-1425)aafs	p.K476fs	C6ORF165_ENST00000369562.4_Frame_Shift_Del_p.K476fs			Q8IYR0	CF165_HUMAN	chromosome 6 open reading frame 165	476										NS(1)|central_nervous_system(1)|large_intestine(5)|lung(8)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		all_cancers(76;3.93e-06)|Acute lymphoblastic leukemia(125;3.55e-10)|Prostate(29;3.51e-09)|all_hematologic(105;3.29e-06)|all_epithelial(107;0.00575)		BRCA - Breast invasive adenocarcinoma(108;0.0419)		AGAAAAGGCCAAAAAAAATAC	0.269													12	433	---	---	---	---					
MDN1	23195	broad.mit.edu	37	6	90432675	90432675	+	Splice_Site	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr6:90432675delT	ENST00000369393.3	-	40	6081	c.5967_splice	c.e40+1	p.K1989_splice	MDN1_ENST00000428876.1_Splice_Site_p.K1989_splice			Q9NU22	MDN1_HUMAN	MDN1, midasin homolog (yeast)	1989					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			NS(1)|breast(13)|central_nervous_system(2)|cervix(3)|endometrium(22)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(52)|liver(1)|lung(83)|ovary(10)|pancreas(1)|prostate(10)|skin(6)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	218		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GAAACTCACCTTTTTTTTGTC	0.403													16	946	---	---	---	---					
FYN	2534	broad.mit.edu	37	6	111983042	111983042	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr6:111983042delT	ENST00000354650.3	-	14	2120	c.1514delA	c.(1513-1515)agfs	p.K505fs	FYN_ENST00000538466.1_Frame_Shift_Del_p.K502fs|FYN_ENST00000368667.2_Frame_Shift_Del_p.K505fs|FYN_ENST00000229471.4_Frame_Shift_Del_p.K450fs|FYN_ENST00000368682.3_Frame_Shift_Del_p.K502fs|FYN_ENST00000368678.4_Frame_Shift_Del_p.K502fs|FYN_ENST00000229470.5_Frame_Shift_Del_p.K453fs|FYN_ENST00000356013.2_Frame_Shift_Del_p.K450fs	NM_002037.5	NP_002028.1	P06241	FYN_HUMAN	FYN oncogene related to SRC, FGR, YES	505	Protein kinase.				axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(17)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)	30		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	TTCAGGGTCCTTTTTCCAGCA	0.562													9	1209	---	---	---	---					
GRM1	2911	broad.mit.edu	37	6	146755630	146755632	+	In_Frame_Del	DEL	GAC	GAC	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr6:146755630_146755632delGAC	ENST00000361719.2	+	9	3753_3755	c.3283_3285delGAC	c.(3283-3285)del	p.D1099del	GRM1_ENST00000492807.2_3'UTR|GRM1_ENST00000355289.4_3'UTR|GRM1_ENST00000392299.2_3'UTR|GRM1_ENST00000507907.1_3'UTR|GRM1_ENST00000282753.1_In_Frame_Del_p.D1099del	NM_001278064.1	NP_001264993.1	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1	1099	Asp/Glu-rich (acidic).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			NS(2)|breast(5)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(23)|lung(54)|ovary(7)|pancreas(2)|prostate(5)|skin(7)|upper_aerodigestive_tract(4)|urinary_tract(1)	126		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	CCCGCCCGCGGACGACGACGACG	0.650													7	688	---	---	---	---					
NOX3	50508	broad.mit.edu	37	6	155743925	155743926	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr6:155743925_155743926delCA	ENST00000159060.2	-	10	1312_1313	c.1210_1211delTG	c.(1210-1212)cfs	p.C404fs		NM_015718.2	NP_056533.1	Q9HBY0	NOX3_HUMAN	NADPH oxidase 3	404							electron carrier activity|flavin adenine dinucleotide binding|iron ion binding			cervix(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|upper_aerodigestive_tract(1)	45		Breast(66;0.0183)		OV - Ovarian serous cystadenocarcinoma(155;2.18e-12)|BRCA - Breast invasive adenocarcinoma(81;0.00815)		CGCGGCAACGCACACACACACT	0.530													7	921	---	---	---	---					
AGPAT4	56895	broad.mit.edu	37	6	161560589	161560589	+	Frame_Shift_Del	DEL	G	G	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr6:161560589delG	ENST00000320285.4	-	8	1119	c.907delC	c.(907-909)ggfs	p.R304fs	AGPAT4_ENST00000366911.5_3'UTR|AGPAT4_ENST00000457520.2_Frame_Shift_Del_p.R142fs	NM_020133.2	NP_064518.1	Q9NRZ5	PLCD_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 4	304					phospholipid biosynthetic process	integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity|protein binding	p.R303fs*7(2)|p.R303fs*60(1)		endometrium(1)|large_intestine(10)|lung(10)|ovary(2)|skin(2)	25		Breast(66;0.000289)|Ovarian(120;0.0266)|Prostate(117;0.0285)		OV - Ovarian serous cystadenocarcinoma(65;2.23e-17)|BRCA - Breast invasive adenocarcinoma(81;3.58e-05)		CAGGGCCGCCGGGGGGGCACC	0.627													7	741	---	---	---	---					
MLLT4-AS1	0	broad.mit.edu	37	6	168227187	168227189	+	RNA	DEL	CAT	CAT	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr6:168227187_168227189delCAT	ENST00000359760.5	-	0	200_202					NR_027906.1																						CCATCGGACCCATCACCGCCCGT	0.680													7	543	---	---	---	---					
ZDHHC4	55146	broad.mit.edu	37	7	6621849	6621849	+	Frame_Shift_Del	DEL	T	T	-	rs34551853		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr7:6621849delT	ENST00000396706.2	+	5	780	c.337delT	c.(337-339)ttfs	p.F115fs	ZDHHC4_ENST00000396713.2_Frame_Shift_Del_p.F115fs|AC079742.4_ENST00000434951.1_RNA|ZDHHC4_ENST00000335965.6_Frame_Shift_Del_p.F115fs|ZDHHC4_ENST00000405731.3_Frame_Shift_Del_p.F115fs|ZDHHC4_ENST00000396709.1_Frame_Shift_Del_p.F115fs|ZDHHC4_ENST00000396707.2_Frame_Shift_Del_p.F115fs			Q9NPG8	ZDHC4_HUMAN	zinc finger, DHHC-type containing 4	115						integral to membrane	acyltransferase activity|zinc ion binding	p.F115fs*3(2)		breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|pancreas(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.1)		TGTAAACCTGTTTTTTTTCAC	0.453													10	1117	---	---	---	---					
COA1	55744	broad.mit.edu	37	7	43679188	43679188	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr7:43679188delT	ENST00000395879.1	-	5	2115	c.434delA	c.(433-435)agfs	p.K145fs	COA1_ENST00000488813.1_5'UTR|COA1_ENST00000223336.6_Frame_Shift_Del_p.K145fs|COA1_ENST00000395880.3_Frame_Shift_Del_p.K145fs|COA1_ENST00000310564.6_Frame_Shift_Del_p.K145fs					cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae)																		TCTCTACTCCTTTTTCACTTC	0.517													7	688	---	---	---	---					
GTF2IRD2P1	0	broad.mit.edu	37	7	72662705	72662705	+	RNA	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr7:72662705delT	ENST00000425256.1	-	0	978					NR_002164.1																						CTTAGttttatttttttttaa	0.333													10	294	---	---	---	---					
STYXL1	51657	broad.mit.edu	37	7	75651194	75651196	+	In_Frame_Del	DEL	ATC	ATC	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr7:75651194_75651196delATC	ENST00000451157.1	-	4	449_451	c.280_282delGAT	c.(280-282)del	p.D94del	STYXL1_ENST00000431581.1_In_Frame_Del_p.D94del|STYXL1_ENST00000359697.3_In_Frame_Del_p.D94del|STYXL1_ENST00000340062.5_Intron|STYXL1_ENST00000248600.1_In_Frame_Del_p.D94del|STYXL1_ENST00000360591.3_In_Frame_Del_p.D94del|STYXL1_ENST00000460184.2_5'UTR			Q9Y6J8	STYL1_HUMAN	serine/threonine/tyrosine interacting-like 1	94	Rhodanese.				intracellular signal transduction|protein dephosphorylation	intracellular	protein binding|protein tyrosine/serine/threonine phosphatase activity			endometrium(1)|large_intestine(2)|lung(4)|ovary(1)|prostate(1)|skin(1)	10						CAGAGTCTGAATCATCATCATCA	0.433													7	1745	---	---	---	---					
PCLO	27445	broad.mit.edu	37	7	82595446	82595447	+	Frame_Shift_Ins	INS	-	-	T			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr7:82595446_82595447insT	ENST00000423517.2	-	4	3994_3995	c.3657_3658insA	c.(3655-3660)aataatfs	p.NN1219fs	PCLO_ENST00000333891.8_Frame_Shift_Ins_p.NN1219fs	NM_014510.2	NP_055325.2	Q9Y6V0	PCLO_HUMAN	piccolo presynaptic cytomatrix protein	1158					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						TCAGGGATTAGTTTTTTTTCTT	0.386													8	743	---	---	---	---					
ABCB4	5244	broad.mit.edu	37	7	87074281	87074282	+	Frame_Shift_Ins	INS	-	-	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr7:87074281_87074282insA	ENST00000265723.4	-	10	1126_1127	c.1015_1016insT	c.(1015-1017)aatfs	p.N339fs	ABCB4_ENST00000359206.3_Frame_Shift_Ins_p.N339fs|ABCB4_ENST00000358400.3_Frame_Shift_Ins_p.N339fs|ABCB4_ENST00000545634.1_Frame_Shift_Ins_p.N339fs|ABCB4_ENST00000453593.1_Frame_Shift_Ins_p.N339fs	NM_000443.3|NM_018849.2	NP_000434.1|NP_061337.1	P21439	MDR3_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 4	339	ABC transmembrane type-1 1.				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity	p.S339fs*3(1)		breast(5)|endometrium(7)|kidney(2)|large_intestine(15)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	77	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					AATTAGGATTGAAAAAAAAACC	0.347													9	181	---	---	---	---					
MEPCE	56257	broad.mit.edu	37	7	100028823	100028825	+	In_Frame_Del	DEL	CCA	CCA	-	rs71555278		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr7:100028823_100028825delCCA	ENST00000310512.2	+	1	1570_1572	c.1182_1184delCCA	c.(1180-1185)cgc>cg	p.RH394del	MEPCE_ENST00000414441.1_5'UTR	NM_019606.5	NP_062552.2	Q7L2J0	MEPCE_HUMAN	methylphosphate capping enzyme	394							methyltransferase activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|liver(2)|lung(9)|prostate(4)|skin(1)|upper_aerodigestive_tract(1)	24	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					GGGGAGGCCGCCACCACCACCAC	0.581													7	319	---	---	---	---					
GIGYF1	64599	broad.mit.edu	37	7	100284335	100284337	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr7:100284335_100284337delCCT	ENST00000275732.5	-	7	1838_1840	c.629_631delAGG	c.(628-633)ggc>g	p.EG210del	GIGYF1_ENST00000471340.2_Intron	NM_022574.4	NP_072096.2	O75420	PERQ1_HUMAN	GRB10 interacting GYF protein 1	210	Poly-Glu.							p.E210delE(1)		central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	23	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					CTCCAGCTGCcctcctcctcctc	0.700													8	213	---	---	---	---					
SRRT	51593	broad.mit.edu	37	7	100482040	100482042	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr7:100482040_100482042delAGG	ENST00000388793.4	+	7	1029_1031	c.809_811delAGG	c.(808-813)cag>c	p.QE270del	SRRT_ENST00000347433.4_In_Frame_Del_p.QE270del|SRRT_ENST00000457580.2_In_Frame_Del_p.QE270del|SRRT_ENST00000432932.1_In_Frame_Del_p.QE270del	NM_001128852.1|NM_015908.5	NP_001122324.1|NP_056992.4	Q9BXP5	SRRT_HUMAN	serrate RNA effector molecule homolog (Arabidopsis)	270	Glu-rich.				cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			breast(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(5)|ovary(3)|prostate(2)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	40						ATCCTGGAGCAGGAGGAGGAGGA	0.596													9	150	---	---	---	---					
DNAJC2	27000	broad.mit.edu	37	7	102964992	102964992	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr7:102964992delT	ENST00000379263.3	-	6	840	c.590delA	c.(589-591)atfs	p.N197fs	DNAJC2_ENST00000249270.7_Frame_Shift_Del_p.N197fs|PMPCB_ENST00000420236.2_Intron	NM_014377.1	NP_055192.1	Q99543	DNJC2_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 2	197	ZRF1-UBD.				'de novo' cotranslational protein folding|chromatin modification|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nuclear membrane	chromatin binding|DNA binding|histone binding|Hsp70 protein binding|ubiquitin binding			endometrium(1)|kidney(9)|large_intestine(6)|lung(4)|ovary(1)	21						TTTAGGAACATTTTTTTTATT	0.239													7	452	---	---	---	---					
FOXP2	93986	broad.mit.edu	37	7	114270016	114270018	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr7:114270016_114270018delCAG	ENST00000393500.3	+	11	1148_1150	c.328_330delCAG	c.(328-330)del	p.Q116del	FOXP2_ENST00000393491.3_In_Frame_Del_p.Q99del|FOXP2_ENST00000350908.4_In_Frame_Del_p.Q191del|FOXP2_ENST00000390668.3_In_Frame_Del_p.Q215del|FOXP2_ENST00000393489.3_In_Frame_Del_p.Q99del|FOXP2_ENST00000360232.4_In_Frame_Del_p.Q191del|FOXP2_ENST00000408937.3_In_Frame_Del_p.Q216del|FOXP2_ENST00000378237.3_In_Frame_Del_p.Q191del|FOXP2_ENST00000393494.2_In_Frame_Del_p.Q191del|FOXP2_ENST00000403559.4_In_Frame_Del_p.Q208del|FOXP2_ENST00000393498.2_In_Frame_Del_p.Q171del			O15409	FOXP2_HUMAN	forkhead box P2	191	Gln-rich.				camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding	p.Q210Q(2)		breast(3)|endometrium(7)|kidney(4)|large_intestine(7)|lung(22)|ovary(4)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	52						gcagcagcaacagcagcagcagc	0.507													17	351	---	---	---	---					
C7orf55-LUC7L2	0	broad.mit.edu	37	7	139094365	139094366	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr7:139094365_139094366delAG	ENST00000354926.4	+	7	1098_1099	c.744_745delAG	c.(742-747)gaagfs	p.EE248fs	LUC7L2_ENST00000541515.3_Frame_Shift_Del_p.EE314fs|C7orf55-LUC7L2_ENST00000541170.3_Frame_Shift_Del_p.EE245fs|C7orf55-LUC7L2_ENST00000263545.6_Frame_Shift_Del_p.EE247fs	NM_016019.3	NP_057103.2																					AACGAAGAGAAGAGAGAGAGAG	0.391													10	152	---	---	---	---					
KMT2C	58508	broad.mit.edu	37	7	151874013	151874013	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr7:151874013delT	ENST00000355193.2	-	38	8743	c.8525delA	c.(8524-8526)atfs	p.N2842fs	KMT2C_ENST00000262189.6_Frame_Shift_Del_p.N2842fs					lysine (K)-specific methyltransferase 2C																		ATTCTCATCATTTTTTTCAGT	0.378													8	740	---	---	---	---					
DLC1	10395	broad.mit.edu	37	8	12957611	12957613	+	In_Frame_Del	DEL	GCT	GCT	-	rs137989738		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr8:12957611_12957613delGCT	ENST00000276297.4	-	9	2642_2644	c.2233_2235delAGC	c.(2233-2235)del	p.S745del	DLC1_ENST00000512044.2_In_Frame_Del_p.S342del|DLC1_ENST00000520226.1_In_Frame_Del_p.S234del|DLC1_ENST00000358919.2_In_Frame_Del_p.S308del	NM_182643.2	NP_872584.2	Q96QB1	RHG07_HUMAN	deleted in liver cancer 1	745	Poly-Ser.				actin cytoskeleton organization|activation of caspase activity|focal adhesion assembly|forebrain development|heart morphogenesis|hindbrain morphogenesis|induction of apoptosis|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of Rho protein signal transduction|negative regulation of stress fiber assembly|neural tube closure|positive regulation of protein dephosphorylation|regulation of cell shape|small GTPase mediated signal transduction	caveola|cytosol|focal adhesion|nucleus	Rho GTPase activator activity|SH2 domain binding			NS(2)|breast(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(39)|lung(32)|ovary(4)|pancreas(2)|prostate(4)|skin(2)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	110						TCTCCGACTGGCTGCTGCTGCTG	0.621													8	335	---	---	---	---					
WRN	7486	broad.mit.edu	37	8	30945377	30945379	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr8:30945377_30945379delAAG	ENST00000298139.5	+	12	1766_1768	c.1517_1519delAAG	c.(1516-1521)aaa>a	p.KE506del		NM_000553.4	NP_000544.2	Q14191	WRN_HUMAN	Werner syndrome, RecQ helicase-like	506					base-excision repair|cellular response to starvation|DNA recombination|DNA synthesis involved in DNA repair|multicellular organismal aging|nucleolus to nucleoplasm transport|positive regulation of hydrolase activity|regulation of apoptosis|replication fork processing|response to oxidative stress|response to UV-C|telomere maintenance	centrosome|nucleolus|nucleoplasm	3'-5' exonuclease activity|ATP binding|ATP-dependent 3'-5' DNA helicase activity|bubble DNA binding|four-way junction helicase activity|G-quadruplex DNA binding|magnesium ion binding|manganese ion binding|protein complex binding|protein homodimerization activity|Y-form DNA binding			central_nervous_system(2)|endometrium(4)|kidney(4)|large_intestine(13)|lung(28)|ovary(3)|skin(3)|upper_aerodigestive_tract(3)	60		Breast(100;0.195)		KIRC - Kidney renal clear cell carcinoma(542;0.147)|Kidney(114;0.176)|Colorectal(111;0.192)		CTTCCTACTAaagaagaagaaga	0.360			"""Mis, N, F, S"""			"""osteosarcoma, meningioma, others"""		Genes defective in diseases associated with sensitivity to DNA damaging agents	Werner syndrome				13	365	---	---	---	---					
SULF1	23213	broad.mit.edu	37	8	70514026	70514026	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr8:70514026delT	ENST00000260128.4	+	10	1740	c.1023delT	c.(1021-1023)ccfs	p.P341fs	SULF1_ENST00000419716.3_Frame_Shift_Del_p.P341fs|SULF1_ENST00000402687.4_Frame_Shift_Del_p.P341fs|SULF1_ENST00000458141.2_Frame_Shift_Del_p.P341fs|SULF1_ENST00000521946.1_3'UTR	NM_015170.2	NP_055985.2	Q8IWU6	SULF1_HUMAN	sulfatase 1	341					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			breast(2)|central_nervous_system(3)|endometrium(5)|kidney(3)|large_intestine(10)|lung(15)|ovary(3)|pancreas(2)|prostate(2)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	52	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			TTCGTGTGCCTTTTTTTATTC	0.408													7	1226	---	---	---	---					
STAU2	27067	broad.mit.edu	37	8	74507471	74507471	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr8:74507471delT	ENST00000355780.5	-	10	1213	c.995delA	c.(994-996)atfs	p.N332fs	STAU2_ENST00000524300.1_Frame_Shift_Del_p.N364fs|STAU2_ENST00000523558.1_Frame_Shift_Del_p.N192fs|STAU2_ENST00000521451.1_Frame_Shift_Del_p.N144fs|STAU2_ENST00000517542.1_Frame_Shift_Del_p.N326fs|STAU2_ENST00000522509.1_Frame_Shift_Del_p.N332fs|STAU2_ENST00000521210.1_Frame_Shift_Del_p.N260fs|STAU2_ENST00000519961.1_Frame_Shift_Del_p.N364fs|STAU2_ENST00000522695.1_Frame_Shift_Del_p.N332fs|STAU2_ENST00000521727.1_Frame_Shift_Del_p.N344fs	NM_014393.2	NP_055208.2	Q9NUL3	STAU2_HUMAN	staufen double-stranded RNA binding protein 2	364	DRBM 4.				transport	endoplasmic reticulum|microtubule|nucleolus	double-stranded RNA binding	p.N332fs*67(1)		breast(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(5)|liver(1)|lung(6)|ovary(1)	19	Breast(64;0.0138)		Epithelial(68;0.026)|BRCA - Breast invasive adenocarcinoma(89;0.0483)|all cancers(69;0.0972)			TTCTGCAGCATTTTTTTTGGC	0.328													9	557	---	---	---	---					
RP11-586K2.1	0	broad.mit.edu	37	8	89498121	89498122	+	RNA	INS	-	-	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr8:89498121_89498122insA	ENST00000521433.1	+	0	179				RP11-586K2.1_ENST00000523254.1_RNA																							gaacagctatgaaaaaaaaaac	0.386													7	60	---	---	---	---					
SLC26A7	115111	broad.mit.edu	37	8	92406218	92406218	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr8:92406218delT	ENST00000276609.3	+	18	2125	c.1886delT	c.(1885-1887)atfs	p.I629fs	SLC26A7_ENST00000523719.1_Frame_Shift_Del_p.I629fs|SLC26A7_ENST00000520249.1_3'UTR|SLC26A7_ENST00000309536.2_Frame_Shift_Del_p.I629fs	NM_052832.2	NP_439897.1	Q8TE54	S26A7_HUMAN	solute carrier family 26 (anion exchanger), member 7	629	STAS.					basolateral plasma membrane|integral to membrane|recycling endosome membrane	anion:anion antiporter activity|bicarbonate transmembrane transporter activity|chloride channel activity|oxalate transmembrane transporter activity|sulfate transmembrane transporter activity			breast(1)|cervix(1)|endometrium(4)|large_intestine(10)|lung(26)|ovary(3)|skin(4)|upper_aerodigestive_tract(1)	50			BRCA - Breast invasive adenocarcinoma(11;0.00802)			GAGAAACCAATTTTTTTTGAA	0.343													9	490	---	---	---	---					
DPYS	1807	broad.mit.edu	37	8	105440214	105440214	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr8:105440214delT	ENST00000351513.2	-	6	1218	c.1086delA	c.(1084-1086)aafs	p.K362fs		NM_001385.2	NP_001376.1	Q14117	DPYS_HUMAN	dihydropyrimidinase	362					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(7)|lung(23)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			CCACCACGCCTTTTTCCCATA	0.478													11	1324	---	---	---	---					
ATAD2	29028	broad.mit.edu	37	8	124368685	124368685	+	Frame_Shift_Del	DEL	A	A	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr8:124368685delA	ENST00000287394.5	-	13	1697	c.1590delT	c.(1588-1590)ttfs	p.F530fs	ATAD2_ENST00000521903.1_5'UTR	NM_014109.3	NP_054828.2	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	530					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(12)|lung(16)|ovary(3)|prostate(3)|skin(1)|urinary_tract(2)	48	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			CAATTTCGTCAAAAAAAATAA	0.413													9	184	---	---	---	---					
FER1L6	654463	broad.mit.edu	37	8	125080031	125080031	+	Frame_Shift_Del	DEL	A	A	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr8:125080031delA	ENST00000522917.1	+	28	3908	c.3702delA	c.(3700-3702)ggfs	p.G1234fs	FER1L6_ENST00000399018.1_Frame_Shift_Del_p.G1234fs|FER1L6-AS2_ENST00000520031.1_RNA	NM_001039112.2	NP_001034201.2	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6 (C. elegans)	1234						integral to membrane				NS(2)|breast(3)|central_nervous_system(2)|endometrium(9)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(18)|liver(1)|lung(49)|ovary(5)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(1)	118	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			ATCCCAAGGGAAAAAAAGGCA	0.388													7	266	---	---	---	---					
AGO2	27161	broad.mit.edu	37	8	141554345	141554345	+	Frame_Shift_Del	DEL	G	G	-	rs148575703	byFrequency	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr8:141554345delG	ENST00000220592.5	-	14	1918	c.1806delC	c.(1804-1806)ccfs	p.P602fs	AGO2_ENST00000519980.1_Frame_Shift_Del_p.P602fs	NM_012154.3	NP_036286.2			argonaute RISC catalytic component 2																		CATCCCCGGCGGGGGGGTGAG	0.647													9	1025	---	---	---	---					
TSNARE1	203062	broad.mit.edu	37	8	143310866	143310868	+	In_Frame_Del	DEL	GAT	GAT	-	rs142964918		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr8:143310866_143310868delGAT	ENST00000524325.1	-	13	1691_1693	c.1516_1518delATC	c.(1516-1518)del	p.I506del	TSNARE1_ENST00000520166.1_In_Frame_Del_p.I507del|TSNARE1_ENST00000307180.3_In_Frame_Del_p.I507del			Q96NA8	TSNA1_HUMAN	t-SNARE domain containing 1	507	Poly-Ile.				vesicle-mediated transport	integral to membrane				breast(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(6)|ovary(2)|stomach(2)|urinary_tract(1)	20	all_cancers(97;7.39e-11)|all_epithelial(106;8.98e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000332)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					CAGAGGTGGCGATGATGATGATG	0.512													13	467	---	---	---	---					
ZC3H3	23144	broad.mit.edu	37	8	144522387	144522389	+	In_Frame_Del	DEL	GAG	GAG	-	rs2272753	byFrequency	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr8:144522387_144522389delGAG	ENST00000262577.5	-	11	2668_2670	c.2637_2639delCTC	c.(2635-2640)tca>tc	p.SS879del		NM_015117.2	NP_055932.2	Q8IXZ2	ZC3H3_HUMAN	zinc finger CCCH-type containing 3	879	Poly-Ser.				mRNA polyadenylation|poly(A)+ mRNA export from nucleus|regulation of mRNA export from nucleus	nucleus	nucleic acid binding|zinc ion binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(13)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)	23	all_cancers(97;8.64e-11)|all_epithelial(106;6.43e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.107)			Gggaggggatgaggaggaggagg	0.655													10	75	---	---	---	---					
FOXD4	2298	broad.mit.edu	37	9	117406	117407	+	Frame_Shift_Ins	INS	-	-	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr9:117406_117407insG	ENST00000382500.2	-	1	1010_1011	c.713_714insC	c.(712-714)cccfs	p.P238fs		NM_207305.4	NP_997188.2	Q12950	FOXD4_HUMAN	forkhead box D4	238	Pro-rich.				axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(5)|large_intestine(2)|lung(3)|prostate(1)|skin(3)	14	all_lung(41;0.218)	all_cancers(5;0.0395)|Acute lymphoblastic leukemia(5;1.91e-07)|all_hematologic(5;1.95e-06)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		CTGGCTGCGGCGGGGCAGGGGC	0.743													8	280	---	---	---	---					
RP11-125B21.2	0	broad.mit.edu	37	9	2552346	2552347	+	RNA	INS	-	-	AA	rs71492001	by1000genomes	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr9:2552346_2552347insAA	ENST00000416826.2	-	0	185				RP11-125B21.2_ENST00000424605.1_RNA|RP11-125B21.2_ENST00000453601.1_RNA																							TCTCTAAATCCAAAAAAAATGT	0.386													7	7	---	---	---	---					
KIAA1432	57589	broad.mit.edu	37	9	5743708	5743708	+	Frame_Shift_Del	DEL	A	A	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr9:5743708delA	ENST00000414202.2	+	10	1257	c.1066delA	c.(1066-1068)aafs	p.K357fs	KIAA1432_ENST00000418622.3_Frame_Shift_Del_p.K278fs|KIAA1432_ENST00000449720.2_Frame_Shift_Del_p.K278fs|KIAA1432_ENST00000251879.6_Frame_Shift_Del_p.K357fs|KIAA1432_ENST00000381532.2_Frame_Shift_Del_p.K278fs	NM_001206557.1|NM_020829.3	NP_001193486.1|NP_065880.2	Q4ADV7	RIC1_HUMAN	KIAA1432	357						integral to membrane				breast(2)|cervix(2)|endometrium(6)|kidney(4)|large_intestine(6)|lung(23)|prostate(1)|upper_aerodigestive_tract(1)	45		Acute lymphoblastic leukemia(23;0.154)		GBM - Glioblastoma multiforme(50;0.000525)|Lung(218;0.122)		TGATGGCACCAAAAAAGATCC	0.279													7	992	---	---	---	---					
NOL6	65083	broad.mit.edu	37	9	33466939	33466939	+	Frame_Shift_Del	DEL	G	G	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr9:33466939delG	ENST00000379471.2	-	15	2008	c.1921delC	c.(1921-1923)tgfs	p.L641fs	NOL6_ENST00000455041.2_Frame_Shift_Del_p.L589fs|NOL6_ENST00000464829.1_Intron			Q9H6R4	NOL6_HUMAN	nucleolar protein 6 (RNA-associated)	641					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			endometrium(4)|kidney(4)|large_intestine(5)|lung(8)|ovary(2)|prostate(2)|skin(2)	27			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		AGTGCATCCAGGGGGCCCCCC	0.512											OREG0019137	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	7	2053	---	---	---	---					
VCP	7415	broad.mit.edu	37	9	35062983	35062985	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr9:35062983_35062985delAAG	ENST00000358901.6	-	7	1696_1698	c.801_803delCTT	c.(799-804)ttg>tt	p.FL267del		NM_007126.3	NP_009057.1	P55072	TERA_HUMAN	valosin containing protein	267					activation of caspase activity|double-strand break repair|endoplasmic reticulum unfolded protein response|ER-associated protein catabolic process|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|retrograde protein transport, ER to cytosol	cytosol|endoplasmic reticulum|microsome|nucleus|proteasome complex	ATP binding|ATPase activity|lipid binding|polyubiquitin binding|protein domain specific binding|protein phosphatase binding			breast(3)|endometrium(2)|kidney(1)|large_intestine(4)|lung(10)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			ACCATTGATCAAGAAGAAGAAGG	0.463													8	912	---	---	---	---					
FKBP15	23307	broad.mit.edu	37	9	115969556	115969556	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr9:115969556delT	ENST00000238256.3	-	3	307	c.190delA	c.(190-192)cafs	p.T64fs	FKBP15_ENST00000493847.1_5'UTR	NM_015258.1	NP_056073.1	Q5T1M5	FKB15_HUMAN	FK506 binding protein 15, 133kDa	64					endocytosis|protein folding	axon|early endosome	actin binding			breast(1)|central_nervous_system(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(9)|ovary(3)|urinary_tract(1)	26						GCTGGTGCTGTTTTTGGTGTT	0.418													8	1503	---	---	---	---					
DAB2IP	153090	broad.mit.edu	37	9	124522389	124522391	+	In_Frame_Del	DEL	AAG	AAG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr9:124522389_124522391delAAG	ENST00000408936.3	+	6	1023_1025	c.841_843delAAG	c.(841-843)del	p.K285del	DAB2IP_ENST00000309989.1_In_Frame_Del_p.K161del|DAB2IP_ENST00000259371.2_In_Frame_Del_p.K257del			Q5VWQ8	DAB2P_HUMAN	DAB2 interacting protein	285	C2.				activation of JUN kinase activity|apoptosis in response to endoplasmic reticulum stress|cellular response to epidermal growth factor stimulus|cellular response to tumor necrosis factor|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of epithelial cell migration|negative regulation of epithelial cell proliferation|negative regulation of epithelial to mesenchymal transition|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of MAP kinase activity|negative regulation of NF-kappaB transcription factor activity|negative regulation of Ras GTPase activity|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|positive regulation of transcription from RNA polymerase II promoter	cytoplasm|intrinsic to internal side of plasma membrane	14-3-3 protein binding|death receptor binding|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity|protein phosphatase 2A binding|Ras GTPase activator activity|signaling adaptor activity			breast(3)|central_nervous_system(2)|cervix(1)|endometrium(3)|large_intestine(8)|lung(6)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	27						GGAGACCGACAAGAAGAAGAAGA	0.601													18	421	---	---	---	---					
ENG	2022	broad.mit.edu	37	9	130581107	130581107	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr9:130581107delT	ENST00000344849.3	-	11	1596	c.1316delA	c.(1315-1317)agfs	p.K439fs	ENG_ENST00000373203.4_Frame_Shift_Del_p.K439fs|RP11-228B15.4_ENST00000425991.1_RNA|RP11-228B15.4_ENST00000439298.1_RNA|ENG_ENST00000480266.1_Intron			P17813	EGLN_HUMAN	endoglin	439	Ser/Thr-rich.				artery morphogenesis|BMP signaling pathway|cell adhesion|cell chemotaxis|central nervous system vasculogenesis|chronological cell aging|detection of hypoxia|extracellular matrix disassembly|heart looping|negative regulation of endothelial cell proliferation|negative regulation of nitric-oxide synthase activity|negative regulation of pathway-restricted SMAD protein phosphorylation|negative regulation of protein autophosphorylation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|patterning of blood vessels|positive regulation of BMP signaling pathway|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of systemic arterial blood pressure|positive regulation of transcription from RNA polymerase II promoter|regulation of cell adhesion|regulation of cell proliferation|regulation of transcription, DNA-dependent|regulation of transforming growth factor beta receptor signaling pathway|smooth muscle tissue development|transforming growth factor beta receptor signaling pathway|venous blood vessel morphogenesis|wound healing	cell surface|external side of plasma membrane|extracellular space|membrane fraction	activin binding|galactose binding|glycosaminoglycan binding|protein homodimerization activity|transforming growth factor beta binding|transforming growth factor beta receptor activity|transforming growth factor beta receptor, cytoplasmic mediator activity|transmembrane receptor activity|type I transforming growth factor beta receptor binding|type II transforming growth factor beta receptor binding			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(3)|lung(6)|ovary(1)|prostate(1)	17						GCAGTGCACCTTTTTCTGGGG	0.637									Juvenile Polyposis;Hereditary Hemorrhagic Telangiectasia				8	1052	---	---	---	---					
CRAT	1384	broad.mit.edu	37	9	131864814	131864814	+	Frame_Shift_Del	DEL	C	C	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr9:131864814delC	ENST00000318080.2	-	5	789	c.495delG	c.(493-495)ggfs	p.G165fs	CRAT_ENST00000464290.1_5'UTR	NM_000755.3|NM_001257363.1	NP_000746.2|NP_001244292.1	P43155	CACP_HUMAN	carnitine O-acetyltransferase	165					energy derivation by oxidation of organic compounds|fatty acid beta-oxidation using acyl-CoA oxidase|transport	endoplasmic reticulum|mitochondrial inner membrane|peroxisomal matrix	carnitine O-acetyltransferase activity			central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(4)|skin(1)|urinary_tract(2)	13				UCEC - Uterine corpus endometrioid carcinoma (4;0.0178)	L-Carnitine(DB00583)	ACAGTGGCTTCCCCCCCAGGT	0.607													9	1890	---	---	---	---					
CEL	1056	broad.mit.edu	37	9	135941982	135941982	+	Frame_Shift_Del	DEL	G	G	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr9:135941982delG	ENST00000372080.4	+	5	629	c.613delG	c.(613-615)ggfs	p.G206fs	CEL_ENST00000351304.7_Frame_Shift_Del_p.G203fs	NM_001807.3	NP_001798.2	P19835	CEL_HUMAN	carboxyl ester lipase	203					cholesterol catabolic process|fatty acid catabolic process|intestinal cholesterol absorption|intestinal lipid catabolic process|pancreatic juice secretion|protein esterification	cytosol|extracellular space	acylglycerol lipase activity|carboxylesterase activity|heparin binding|sterol esterase activity|triglyceride lipase activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|pancreas(2)|skin(1)	20				OV - Ovarian serous cystadenocarcinoma(145;1.03e-40)|Epithelial(140;3.58e-37)|GBM - Glioblastoma multiforme(294;0.00164)|READ - Rectum adenocarcinoma(205;0.196)		CGCGGCCTTCGGGGGGGACCC	0.642													9	1023	---	---	---	---					
SURF2	6835	broad.mit.edu	37	9	136226880	136226882	+	In_Frame_Del	DEL	GGA	GGA	-	rs149969130		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr9:136226880_136226882delGGA	ENST00000371964.4	+	4	433_435	c.392_394delGGA	c.(391-396)cgg>c	p.RR133del	SURF2_ENST00000495524.1_3'UTR	NM_017503.3	NP_059973.3	Q15527	SURF2_HUMAN	surfeit 2	133							protein binding			breast(1)|large_intestine(1)|lung(4)	6				OV - Ovarian serous cystadenocarcinoma(145;4.87e-07)|Epithelial(140;4.02e-06)|all cancers(34;3.71e-05)		CTGGTGCACCGGAGGAGGAGGAG	0.635													7	156	---	---	---	---					
GRIN1	2902	broad.mit.edu	37	9	140056884	140056886	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr9:140056884_140056886delGAG	ENST00000371561.3	+	13	2877_2879	c.1780_1782delGAG	c.(1780-1782)del	p.E598del	GRIN1_ENST00000350902.5_In_Frame_Del_p.E598del|GRIN1_ENST00000371550.4_In_Frame_Del_p.E598del|GRIN1_ENST00000371555.4_In_Frame_Del_p.E619del|GRIN1_ENST00000371559.4_In_Frame_Del_p.E598del|GRIN1_ENST00000371560.3_In_Frame_Del_p.E619del|GRIN1_ENST00000371553.3_In_Frame_Del_p.E619del|GRIN1_ENST00000371546.4_In_Frame_Del_p.E619del|GRIN1_ENST00000471122.1_3'UTR|GRIN1_ENST00000315048.3_In_Frame_Del_p.E598del	NM_007327.3	NP_015566.1	Q05586	NMDZ1_HUMAN	glutamate receptor, ionotropic, N-methyl D-aspartate 1	598					ionotropic glutamate receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of excitatory postsynaptic membrane potential|response to ethanol|visual learning	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane|synaptic vesicle|synaptosome	calcium ion binding|calmodulin binding|extracellular-glutamate-gated ion channel activity|glutamate binding|glycine binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	15	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;6.87e-05)|Epithelial(140;0.00095)	L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	GGTGAACAGCGAGGAGGAGGAGG	0.739													12	219	---	---	---	---					
SFMBT2	57713	broad.mit.edu	37	10	7212995	7212997	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr10:7212995_7212997delCTC	ENST00000361972.4	-	20	2527_2529	c.2437_2439delGAG	c.(2437-2439)del	p.E813del	SFMBT2_ENST00000397167.1_In_Frame_Del_p.E813del	NM_001018039.1	NP_001018049.1	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	813					regulation of transcription, DNA-dependent	nucleus				NS(2)|breast(3)|central_nervous_system(4)|endometrium(7)|kidney(2)|large_intestine(26)|lung(34)|ovary(5)|pancreas(2)|skin(9)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	99						GAACCAGTCTCTCCTCCTCCTCC	0.596													9	972	---	---	---	---					
KIAA1462	57608	broad.mit.edu	37	10	30316501	30316503	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr10:30316501_30316503delCTG	ENST00000375377.1	-	3	2675_2677	c.2574_2576delCAG	c.(2572-2577)agt>ag	p.SS858del		NM_020848.2	NP_065899.1	Q9P266	K1462_HUMAN	KIAA1462	858	Ser-rich.									breast(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(17)|lung(23)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)	75						ACTCTCCTCActgctgctgctgc	0.571													21	429	---	---	---	---					
ERCC6	2074	broad.mit.edu	37	10	50732139	50732141	+	In_Frame_Del	DEL	CCT	CCT	-	rs4253047	byFrequency	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr10:50732139_50732141delCCT	ENST00000355832.5	-	5	1413_1415	c.1335_1337delAGG	c.(1333-1338)ggt>gg	p.GG445del	PGBD3_ENST00000374127.3_5'UTR|PGBD3_ENST00000603152.1_In_Frame_Del_p.GG445del|ERCC6-PGBD3_ENST00000515869.1_In_Frame_Del_p.GG445del|ERCC6-PGBD3_ENST00000447839.2_In_Frame_Del_p.GG445del	NM_000124.2	NP_000115.1	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent repair deficiency, complementation group 6	445	Gly-rich.				base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			breast(5)|central_nervous_system(1)|endometrium(6)|kidney(5)|large_intestine(15)|lung(19)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64						CACTTTCCGACCTCCTCCTCCTC	0.458								Direct reversal of damage;Nucleotide excision repair (NER)					7	793	---	---	---	---					
ARID5B	84159	broad.mit.edu	37	10	63852298	63852298	+	Frame_Shift_Del	DEL	A	A	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr10:63852298delA	ENST00000279873.7	+	10	3486	c.3076delA	c.(3076-3078)aafs	p.K1027fs	ARID5B_ENST00000309334.5_Frame_Shift_Del_p.K784fs	NM_032199.2	NP_115575.1	Q14865	ARI5B_HUMAN	AT rich interactive domain 5B (MRF1-like)	1027					liver development|negative regulation of transcription, DNA-dependent|positive regulation of sequence-specific DNA binding transcription factor activity|transcription, DNA-dependent		protein binding|transcription regulatory region DNA binding			NS(1)|breast(2)|endometrium(13)|kidney(3)|large_intestine(7)|lung(9)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	44	Prostate(12;0.016)|all_hematologic(501;0.215)					GATTGCAGGGAAAAAGGCCCG	0.607													8	699	---	---	---	---					
SPOCK2	9806	broad.mit.edu	37	10	73822559	73822561	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr10:73822559_73822561delCCT	ENST00000373109.2	-	11	1676_1678	c.1232_1234delAGG	c.(1231-1236)ggc>g	p.EG411del	SPOCK2_ENST00000536168.1_In_Frame_Del_p.EG411del|SPOCK2_ENST00000317376.4_In_Frame_Del_p.EG411del	NM_001244950.1	NP_001231879.1	Q92563	TICN2_HUMAN	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2	411	Glu-rich.				extracellular matrix organization|regulation of cell differentiation|signal transduction|synapse assembly	proteinaceous extracellular matrix	calcium ion binding			endometrium(2)|large_intestine(2)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	9						CCTGCCTCGCcctcctcctcctc	0.670													7	187	---	---	---	---					
SLIT1	6585	broad.mit.edu	37	10	98778793	98778794	+	Frame_Shift_Ins	INS	-	-	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr10:98778793_98778794insG	ENST00000266058.4	-	27	3062_3063	c.2817_2818insC	c.(2815-2820)acgccafs	p.P940fs	SLIT1_ENST00000371070.4_Frame_Shift_Ins_p.P940fs|ARHGAP19-SLIT1_ENST00000453547.2_3'UTR	NM_003061.2	NP_003052.2	O75093	SLIT1_HUMAN	slit homolog 1 (Drosophila)	940	EGF-like 1.				axon extension involved in axon guidance|forebrain morphogenesis|motor axon guidance|negative chemotaxis|negative regulation of synaptogenesis	cytoplasm|extracellular space	calcium ion binding|Roundabout binding			breast(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(16)|lung(37)|ovary(5)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	78		Colorectal(252;0.162)		Epithelial(162;2.02e-08)|all cancers(201;1.5e-06)		TCGTTGTGGCAGGTGCCCTGGT	0.639													8	353	---	---	---	---					
ABCC2	1244	broad.mit.edu	37	10	101559000	101559000	+	Frame_Shift_Del	DEL	A	A	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr10:101559000delA	ENST00000370449.4	+	8	1017	c.904delA	c.(904-906)aafs	p.K303fs		NM_000392.3	NP_000383.1	Q92887	MRP2_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	303						apical plasma membrane|integral to plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|organic anion transmembrane transporter activity			NS(1)|breast(5)|endometrium(9)|kidney(2)|large_intestine(20)|liver(1)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	67		Colorectal(252;0.234)		Epithelial(162;2.77e-10)|all cancers(201;2.47e-08)	Adenosine triphosphate(DB00171)|Norgestimate(DB00957)|Pravastatin(DB00175)|Saquinavir(DB01232)|Sulfinpyrazone(DB01138)	GTCTGGGACCAAAAAAGATGT	0.403													8	1015	---	---	---	---					
SCD	6319	broad.mit.edu	37	10	102107836	102107838	+	In_Frame_Del	DEL	ACC	ACC	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr10:102107836_102107838delACC	ENST00000370355.2	+	2	424_426	c.43_45delACC	c.(43-45)del	p.T19del		NM_005063.4	NP_005054.3	O00767	ACOD_HUMAN	stearoyl-CoA desaturase (delta-9-desaturase)	19					fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	iron ion binding|stearoyl-CoA 9-desaturase activity			endometrium(1)|large_intestine(3)|lung(5)	9		Colorectal(252;0.0323)		Epithelial(162;1.97e-10)|all cancers(201;1.73e-08)		TAGCTCCTATACCACCACCACCA	0.581													12	826	---	---	---	---					
NOLC1	9221	broad.mit.edu	37	10	103919000	103919002	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr10:103919000_103919002delAGC	ENST00000405356.1	+	6	893_895	c.658_660delAGC	c.(658-660)del	p.S227del	NOLC1_ENST00000605788.1_In_Frame_Del_p.S227del|NOLC1_ENST00000488254.2_In_Frame_Del_p.S228del|NOLC1_ENST00000603742.1_5'UTR			Q14978	NOLC1_HUMAN	nucleolar and coiled-body phosphoprotein 1	227	11 X 12 AA approximate repeats of an acidic serine cluster.|Interacts with RPA194.				mitosis|rRNA processing	cytoplasm|nucleolus	ATP binding|GTP binding|protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(1)|upper_aerodigestive_tract(1)	31		Colorectal(252;0.122)		Epithelial(162;5.19e-08)|all cancers(201;9.43e-07)		tagcagcagtagcagcagcagca	0.517													13	662	---	---	---	---					
TACC2	10579	broad.mit.edu	37	10	123970380	123970380	+	Frame_Shift_Del	DEL	C	C	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr10:123970380delC	ENST00000369005.1	+	9	6780	c.6440delC	c.(6439-6441)acfs	p.T2147fs	TACC2_ENST00000515603.1_Frame_Shift_Del_p.T2102fs|TACC2_ENST00000360561.3_Frame_Shift_Del_p.T225fs|TACC2_ENST00000515273.1_Frame_Shift_Del_p.T2151fs|TACC2_ENST00000368999.1_Frame_Shift_Del_p.T225fs|TACC2_ENST00000369001.1_5'UTR|TACC2_ENST00000334433.3_Frame_Shift_Del_p.T2147fs|TACC2_ENST00000453444.2_Frame_Shift_Del_p.T2151fs|TACC2_ENST00000513429.1_Frame_Shift_Del_p.T293fs|TACC2_ENST00000260733.3_Frame_Shift_Del_p.T225fs|TACC2_ENST00000369004.3_Frame_Shift_Del_p.T225fs|TACC2_ENST00000369000.1_5'UTR|TACC2_ENST00000358010.1_Frame_Shift_Del_p.T293fs	NM_206862.2	NP_996744.2	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing protein 2	2147						microtubule organizing center|nucleus	nuclear hormone receptor binding			NS(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(15)|lung(27)|ovary(6)|prostate(3)|skin(8)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(3)	83		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CCCACAGAGACCCCCCCAGTG	0.522													11	1063	---	---	---	---					
NLRP6	171389	broad.mit.edu	37	11	281553	281555	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:281553_281555delGAG	ENST00000534750.1	+	4	2024_2026	c.1819_1821delGAG	c.(1819-1821)del	p.E611del	NLRP6_ENST00000312165.5_In_Frame_Del_p.E611del	NM_001276700.1	NP_001263629.1	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	611	Poly-Glu.					cytoplasm	ATP binding			breast(1)|skin(1)|upper_aerodigestive_tract(2)	4		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		CGAAGAGCCAGAGGAGGAGGAGG	0.670													22	655	---	---	---	---					
IFITM1	8519	broad.mit.edu	37	11	314210	314210	+	Frame_Shift_Del	DEL	C	C	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:314210delC	ENST00000408968.3	+	1	358	c.40delC	c.(40-42)ccfs	p.P15fs	IFITM1_ENST00000528780.1_Frame_Shift_Del_p.P15fs|IFITM1_ENST00000328221.5_Frame_Shift_Del_p.P15fs	NM_003641.3	NP_003632.3	P13164	IFM1_HUMAN	interferon induced transmembrane protein 1	15					negative regulation of cell proliferation|regulation of immune response|response to virus|type I interferon-mediated signaling pathway	integral to membrane|plasma membrane	protein binding|receptor signaling protein activity			large_intestine(1)|lung(3)	4		all_cancers(49;2e-09)|all_epithelial(84;3.36e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;8.85e-28)|Epithelial(43;5.52e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0327)|LUSC - Lung squamous cell carcinoma(625;0.122)		GCTGGGGCCACCCCCCAGCAC	0.562													7	502	---	---	---	---					
TSPAN4	0	broad.mit.edu	37	11	864443	864445	+	In_Frame_Del	DEL	CTG	CTG	-	rs61867552	byFrequency	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:864443_864445delCTG	ENST00000397404.1	+	5	521_523	c.262_264delCTG	c.(262-264)del	p.L92del	TSPAN4_ENST00000525201.1_In_Frame_Del_p.L28del|TSPAN4_ENST00000346501.4_In_Frame_Del_p.L92del|TSPAN4_ENST00000409531.1_In_Frame_Del_p.L111del|TSPAN4_ENST00000397396.1_In_Frame_Del_p.L28del|TSPAN4_ENST00000397411.2_In_Frame_Del_p.L92del|TSPAN4_ENST00000409543.2_In_Frame_Del_p.L92del|TSPAN4_ENST00000397408.1_In_Frame_Del_p.L92del|TSPAN4_ENST00000397406.1_In_Frame_Del_p.L92del|TSPAN4_ENST00000397397.2_In_Frame_Del_p.L92del	NM_001025237.1	NP_001020408.1	O14817	TSN4_HUMAN	tetraspanin 4	92					protein complex assembly	integral to plasma membrane				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)	3		all_cancers(49;2.64e-08)|all_epithelial(84;4.17e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)|all_lung(207;0.24)		all cancers(45;4.32e-25)|Epithelial(43;3.29e-24)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		ACAGTTCTTCCTGCTGCTGCTGC	0.650													32	628	---	---	---	---					
AP2A2	161	broad.mit.edu	37	11	970195	970195	+	Frame_Shift_Del	DEL	A	A	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:970195delA	ENST00000448903.2	+	3	304	c.163delA	c.(163-165)aafs	p.K57fs	AP2A2_ENST00000332231.5_Frame_Shift_Del_p.K57fs|AP2A2_ENST00000534328.1_Frame_Shift_Del_p.K57fs	NM_001242837.1|NM_012305.3	NP_001229766.1|NP_036437.1	O94973	AP2A2_HUMAN	adaptor-related protein complex 2, alpha 2 subunit	57	Lipid-binding.				axon guidance|endocytosis|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|regulation of defense response to virus by virus|synaptic transmission|viral reproduction	AP-2 adaptor complex|cytosol	lipid binding|protein transporter activity	p.K57fs*24(1)		breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(6)|ovary(2)	21		all_cancers(49;9.46e-06)|Breast(177;0.00257)|all_epithelial(84;0.0027)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.75e-24)|BRCA - Breast invasive adenocarcinoma(625;5.73e-05)|Lung(200;0.0696)|LUSC - Lung squamous cell carcinoma(625;0.082)		TGGCTATAGTAAAAAAAAGTA	0.488													8	682	---	---	---	---					
APBB1	322	broad.mit.edu	37	11	6432090	6432092	+	In_Frame_Del	DEL	TCC	TCC	-	rs145320037		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:6432090_6432092delTCC	ENST00000389906.2	-	2	585_587	c.486_488delGGA	c.(484-489)gat>ga	p.ED162del	APBB1_ENST00000299402.6_In_Frame_Del_p.ED162del|APBB1_ENST00000533407.1_Intron|APBB1_ENST00000311051.3_In_Frame_Del_p.ED162del	NM_001257325.1	NP_001244254.1	O00213	APBB1_HUMAN	amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)	162	Glu-rich.				apoptosis|axonogenesis|cell cycle arrest|histone H4 acetylation|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of thymidylate synthase biosynthetic process|positive regulation of apoptosis|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|signal transduction|transcription, DNA-dependent	cytoplasm|growth cone|lamellipodium|nucleus|plasma membrane|synapse	beta-amyloid binding|chromatin binding|histone binding|proline-rich region binding|transcription factor binding	p.E162D(1)		breast(4)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|prostate(2)|skin(1)|urinary_tract(1)	24		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;6.49e-08)|BRCA - Breast invasive adenocarcinoma(625;0.194)		atcatcatcatcctcctcctcct	0.635													12	197	---	---	---	---					
OR10A2	341276	broad.mit.edu	37	11	6891253	6891255	+	In_Frame_Del	DEL	TTC	TTC	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:6891253_6891255delTTC	ENST00000307322.4	+	1	330_332	c.268_270delTTC	c.(268-270)del	p.F94del		NM_001004460.1	NP_001004460.1	Q9H208	O10A2_HUMAN	olfactory receptor, family 10, subfamily A, member 2	94					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(3)|large_intestine(4)|lung(12)|urinary_tract(1)	24		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.89e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		TCAGATGTATTTCTTCTTCTTCT	0.517													11	821	---	---	---	---					
CALCA	796	broad.mit.edu	37	11	14991489	14991490	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:14991489_14991490delCT	ENST00000361010.3	-	3	292_293	c.218_219delAG	c.(217-219)gfs	p.E73fs	CALCA_ENST00000486207.1_Frame_Shift_Del_p.E73fs|CALCA_ENST00000331587.4_Frame_Shift_Del_p.E73fs|CALCA_ENST00000359642.3_Frame_Shift_Del_p.E73fs|CALCB_ENST00000523376.1_Intron|CALCA_ENST00000396372.2_Frame_Shift_Del_p.E73fs	NM_001033953.2	NP_001029125.1	P06881	CALCA_HUMAN	calcitonin-related polypeptide alpha	73					activation of adenylate cyclase activity|cell-cell signaling|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|endothelial cell migration|endothelial cell proliferation|leukocyte cell-cell adhesion|negative regulation of blood pressure|negative regulation of bone resorption|negative regulation of calcium ion transport into cytosol|negative regulation of osteoclast differentiation|neurological system process involved in regulation of systemic arterial blood pressure|positive regulation of interleukin-1 alpha production|positive regulation of interleukin-8 production|positive regulation of macrophage differentiation|positive regulation of vasodilation|regulation of blood pressure|vasculature development|vasodilation	cytosol|extracellular space	hormone activity			central_nervous_system(1)|large_intestine(4)|lung(2)|upper_aerodigestive_tract(1)	8					Phentolamine(DB00692)	ACCTGGAGCCCTCTCTCTCTTG	0.624											OREG0020791	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	545	---	---	---	---					
NAV2	89797	broad.mit.edu	37	11	19901475	19901477	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:19901475_19901477delAGC	ENST00000396085.1	+	5	933_935	c.572_574delAGC	c.(571-576)aag>a	p.KQ191del	NAV2_ENST00000396087.3_In_Frame_Del_p.KQ191del|NAV2_ENST00000534229.1_3'UTR|NAV2_ENST00000540292.1_In_Frame_Del_p.KQ122del|NAV2_ENST00000360655.4_In_Frame_Del_p.KQ127del|NAV2_ENST00000527559.2_In_Frame_Del_p.KQ120del|NAV2_ENST00000349880.4_In_Frame_Del_p.KQ191del	NM_182964.5	NP_892009.3	Q8IVL1	NAV2_HUMAN	neuron navigator 2	191	CH.					nucleus	ATP binding|helicase activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(7)|large_intestine(26)|lung(38)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	116						TCCCGATACAagcagcagcagca	0.611													8	451	---	---	---	---					
CCDC73	493860	broad.mit.edu	37	11	32635951	32635951	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:32635951delT	ENST00000335185.5	-	16	1956	c.1913delA	c.(1912-1914)atfs	p.N638fs		NM_001008391.2	NP_001008392.2	Q6ZRK6	CCD73_HUMAN	coiled-coil domain containing 73	638								p.N638fs*18(1)		NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(9)|lung(20)|ovary(2)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	51	Breast(20;0.112)					TGGAACAGGATTTTTTTTTAT	0.313													9	192	---	---	---	---					
MYBPC3	4607	broad.mit.edu	37	11	47359101	47359103	+	In_Frame_Del	DEL	TCT	TCT	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:47359101_47359103delTCT	ENST00000545968.1	-	25	2495_2497	c.2441_2443delAGA	c.(2440-2445)agc>a	p.KS814del	MYBPC3_ENST00000399249.2_In_Frame_Del_p.KS814del|MYBPC3_ENST00000256993.4_In_Frame_Del_p.KS813del	NM_000256.3	NP_000247.2	Q14896	MYPC3_HUMAN	myosin binding protein C, cardiac	813	Fibronectin type-III 1.				cardiac muscle contraction|cell adhesion|muscle filament sliding|regulation of muscle filament sliding|regulation of striated muscle contraction|ventricular cardiac muscle tissue morphogenesis	C zone|cytosol|striated muscle myosin thick filament	actin binding|ATPase activator activity|metal ion binding|myosin heavy chain binding|structural constituent of muscle|titin binding			breast(2)|central_nervous_system(2)|endometrium(9)|kidney(1)|large_intestine(4)|lung(16)|ovary(3)|prostate(3)|urinary_tract(2)	42				Lung(87;0.176)		CACCGGTAGCTCTTCTTCTTCTT	0.601													10	347	---	---	---	---					
PRG2	5553	broad.mit.edu	37	11	57156679	57156681	+	In_Frame_Del	DEL	TCT	TCT	-	rs77900153	byFrequency	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:57156679_57156681delTCT	ENST00000311862.5	-	3	241_243	c.168_170delAGA	c.(166-171)gag>ga	p.EE58del	RP11-872D17.8_ENST00000529411.1_In_Frame_Del_p.EE163del|PRG2_ENST00000525955.1_In_Frame_Del_p.EE58del|PRG2_ENST00000533605.1_In_Frame_Del_p.EE58del	NM_001243245.1|NM_002728.4	NP_001230174.1|NP_002719.3			proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)											central_nervous_system(1)|endometrium(2)|large_intestine(3)|lung(4)	10				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCACTCCTCCTCTTCCTCCAGCT	0.547													10	601	---	---	---	---					
FADS2	9415	broad.mit.edu	37	11	61607885	61607887	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:61607885_61607887delTCC	ENST00000278840.4	+	3	1028_1030	c.398_400delTCC	c.(397-402)ttc>t	p.FL133del	FADS2_ENST00000522056.1_In_Frame_Del_p.FL102del|FADS2_ENST00000521849.1_In_Frame_Del_p.FL133del|FADS2_ENST00000257261.6_In_Frame_Del_p.FL111del	NM_004265.2	NP_004256.1	O95864	FADS2_HUMAN	fatty acid desaturase 2	133					electron transport chain|transport|unsaturated fatty acid biosynthetic process	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	heme binding			breast(2)|kidney(2)|large_intestine(4)|liver(1)|lung(2)|ovary(2)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	20					Alpha-Linolenic Acid(DB00132)	CACGTGTTCTTCCTCCTCCTCCT	0.537													7	1070	---	---	---	---					
SLC3A2	6520	broad.mit.edu	37	11	62649528	62649529	+	Frame_Shift_Ins	INS	-	-	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:62649528_62649529insA	ENST00000377892.1	+	6	1208_1209	c.984_985insA	c.(982-987)gcaaaafs	p.AK328fs	SLC3A2_ENST00000535296.1_Frame_Shift_Ins_p.AK266fs|SLC3A2_ENST00000377891.2_Frame_Shift_Ins_p.AK298fs|SLC3A2_ENST00000377890.2_Frame_Shift_Ins_p.AK297fs|SLC3A2_ENST00000338663.7_Frame_Shift_Ins_p.AK196fs|SLC3A2_ENST00000538682.1_3'UTR|SLC3A2_ENST00000536981.1_5'UTR|SLC3A2_ENST00000377889.2_Frame_Shift_Ins_p.AK235fs			P08195	4F2_HUMAN	solute carrier family 3 (amino acid transporter heavy chain), member 2	297					blood coagulation|carbohydrate metabolic process|cell growth|cellular nitrogen compound metabolic process|leucine import|leukocyte migration|tryptophan transport	apical plasma membrane|cell surface|integral to membrane|melanosome	calcium:sodium antiporter activity|catalytic activity|cation binding|neutral amino acid transmembrane transporter activity|protein binding	p.K331fs*31(1)		endometrium(1)|kidney(3)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(2)	22						TGCAATCGGCTAAAAAAAAGAG	0.460													10	443	---	---	---	---					
PCNXL3	399909	broad.mit.edu	37	11	65404248	65404259	+	In_Frame_Del	DEL	CCTCAGCCTCAG	CCTCAGCCTCAG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:65404248_65404259delCCTCAGCCTCAG	ENST00000355703.3	+	35	6443_6454	c.5904_5915delCCTCAGCCTCAG	c.(5902-5916)gac>ga	p.DLSLS1968del		NM_032223.2	NP_115599.2	Q9H6A9	PCX3_HUMAN	pecanex-like 3 (Drosophila)	1968						integral to membrane				breast(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(1)	13						CGCCTCTAGAcctcagcctcagcctcagcctc	0.646													2	4	---	---	---	---					
POLD3	10714	broad.mit.edu	37	11	74336608	74336609	+	Frame_Shift_Ins	INS	-	-	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:74336608_74336609insA	ENST00000263681.2	+	8	1018_1019	c.889_890insA	c.(889-891)aaafs	p.K297fs	POLD3_ENST00000527458.1_Frame_Shift_Ins_p.K258fs|POLD3_ENST00000532497.1_Frame_Shift_Ins_p.K191fs	NM_006591.2	NP_006582.1	Q15054	DPOD3_HUMAN	polymerase (DNA-directed), delta 3, accessory subunit	297					base-excision repair|DNA strand elongation involved in DNA replication|DNA synthesis involved in DNA repair|mismatch repair|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm	DNA-directed DNA polymerase activity|protein binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|stomach(1)	18	Breast(11;3.21e-06)					GCTGCAGAAGGAAAAAAAAAGG	0.460													8	155	---	---	---	---					
UVRAG	7405	broad.mit.edu	37	11	75694430	75694431	+	Splice_Site	INS	-	-	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:75694430_75694431insA	ENST00000356136.3	+	8	940_941		c.e8-1		UVRAG_ENST00000532130.1_Splice_Site|UVRAG_ENST00000533454.1_Splice_Site|UVRAG_ENST00000531818.1_Splice_Site|UVRAG_ENST00000528420.1_Splice_Site	NM_003369.3	NP_003360.2	Q9P2Y5	UVRAG_HUMAN	UV radiation resistance associated						DNA repair|positive regulation of autophagy	early endosome|late endosome|lysosome	protein binding			central_nervous_system(1)|cervix(3)|endometrium(3)|kidney(1)|large_intestine(2)|lung(15)|skin(5)|urinary_tract(2)	32						TATTTATTTAGAAAAAAAAAAG	0.302													18	211	---	---	---	---					
MMP12	4321	broad.mit.edu	37	11	102738795	102738796	+	RNA	INS	-	-	T	rs33924686	by1000genomes	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:102738795_102738796insT	ENST00000532855.1	-	0	725_726							P39900	MMP12_HUMAN	matrix metallopeptidase 12 (macrophage elastase)						positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding	p.N211fs*20(2)		autonomic_ganglia(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	26		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	AGGAACAAGTGGTGCCTAAGAA	0.416													11	55	---	---	---	---					
DDX10	1662	broad.mit.edu	37	11	108559769	108559769	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:108559769delT	ENST00000526794.1	+	7	987	c.955delT	c.(955-957)ttfs	p.F320fs	DDX10_ENST00000322536.3_Frame_Shift_Del_p.F320fs			Q13206	DDX10_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 10	320	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|RNA binding|RNA helicase activity			breast(2)|endometrium(5)|kidney(2)|large_intestine(4)|lung(11)|pancreas(1)|prostate(2)	27		all_cancers(61;1.29e-11)|all_epithelial(67;2.96e-07)|Melanoma(852;1.54e-05)|Acute lymphoblastic leukemia(157;4.24e-05)|all_hematologic(158;0.000141)|Breast(348;0.026)|all_neural(223;0.0729)		BRCA - Breast invasive adenocarcinoma(274;2.48e-05)|Epithelial(105;4.35e-05)|all cancers(92;0.000609)|OV - Ovarian serous cystadenocarcinoma(223;0.133)		GAGCATTGTATTTTTTTCCAG	0.353			T	NUP98	AML*								8	1571	---	---	---	---					
IFT46	56912	broad.mit.edu	37	11	118427683	118427685	+	In_Frame_Del	DEL	ATC	ATC	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:118427683_118427685delATC	ENST00000264020.2	-	5	651_653	c.274_276delGAT	c.(274-276)del	p.D92del	IFT46_ENST00000264021.3_In_Frame_Del_p.D41del|IFT46_ENST00000530872.1_In_Frame_Del_p.D92del	NM_020153.3	NP_064538.3	Q9NQC8	IFT46_HUMAN	intraflagellar transport 46 homolog (Chlamydomonas)	41					flagellum assembly|intraflagellar transport|protein stabilization	microtubule basal body|microtubule-based flagellum|nucleus	protein C-terminus binding			central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(1)|lung(4)	9						TTTCAGATGAatcatcatcatca	0.478													12	489	---	---	---	---					
BCL9L	283149	broad.mit.edu	37	11	118770651	118770652	+	Frame_Shift_Ins	INS	-	-	G	rs139987150		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:118770651_118770652insG	ENST00000334801.3	-	7	4344_4345	c.3380_3381insC	c.(3379-3381)cccfs	p.P1127fs	BCL9L_ENST00000526143.1_5'UTR	NM_182557.2	NP_872363.1	Q86UU0	BCL9L_HUMAN	B-cell CLL/lymphoma 9-like	1127	Pro-rich.				negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		transcription coactivator activity			NS(3)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(13)|lung(20)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(2)	56	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.103)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.66e-05)		GCGGTGGTGGTGGGGGGGGCAG	0.703													7	205	---	---	---	---					
CBL	867	broad.mit.edu	37	11	119149356	119149358	+	In_Frame_Del	DEL	ATG	ATG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:119149356_119149358delATG	ENST00000264033.4	+	9	1740_1742	c.1364_1366delATG	c.(1363-1368)tat>t	p.YD455del		NM_005188.3	NP_005179.2	P22681	CBL_HUMAN	Cbl proto-oncogene, E3 ubiquitin protein ligase	455	Asp/Glu-rich (acidic).				epidermal growth factor receptor signaling pathway|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of receptor-mediated endocytosis	cytosol|nucleus	calcium ion binding|sequence-specific DNA binding transcription factor activity|SH3 domain binding|signal transducer activity|ubiquitin-protein ligase activity|zinc ion binding	p.E366_K477del(1)		breast(2)|central_nervous_system(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(194)|kidney(3)|large_intestine(9)|lung(30)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	251		Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.92e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.000784)		TCCCCAAATTATGATGATGATGA	0.473			"""T, Mis S, O"""	MLL	"""AML, JMML, MDS"""				Noonan syndrome;CBL gene-associated Juvenile Myelomonocytic Leukemia and Developmental Anomalies				11	398	---	---	---	---					
PVRL1	5818	broad.mit.edu	37	11	119535678	119535680	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:119535678_119535680delCCT	ENST00000264025.3	-	6	1861_1863	c.1331_1333delAGG	c.(1330-1335)ggc>g	p.EG444del	PVRL1_ENST00000341398.2_Intron	NM_002855.4	NP_002846.3	Q15223	PVRL1_HUMAN	poliovirus receptor-related 1 (herpesvirus entry mediator C)	444	Poly-Glu.				adherens junction organization|cell junction assembly|entry of virus into host cell|heterophilic cell-cell adhesion|homophilic cell adhesion|immune response	cell-cell adherens junction|extracellular region|integral to membrane	cell adhesion molecule binding|coreceptor activity|protein homodimerization activity	p.E444fs*>73(1)		breast(1)|endometrium(3)|kidney(2)|large_intestine(9)|liver(1)|lung(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	27		Breast(348;0.037)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.29e-05)		CCTCCACCGCcctcctcctcctc	0.660													11	179	---	---	---	---					
NFRKB	4798	broad.mit.edu	37	11	129752495	129752496	+	Frame_Shift_Ins	INS	-	-	T	rs149369172		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr11:129752495_129752496insT	ENST00000446488.3	-	9	1035_1036	c.932_933insA	c.(931-933)agtfs	p.S311fs	NFRKB_ENST00000524794.1_Frame_Shift_Ins_p.S336fs|NFRKB_ENST00000524746.1_Frame_Shift_Ins_p.S311fs|NFRKB_ENST00000304521.5_Frame_Shift_Ins_p.S311fs	NM_001143835.1	NP_001137307.1	Q6P4R8	NFRKB_HUMAN	nuclear factor related to kappaB binding protein	311	Lys-rich.				DNA recombination|DNA repair|inflammatory response|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Ino80 complex	DNA binding|protease binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(2)|lung(13)|ovary(4)|skin(3)|urinary_tract(1)	32	all_hematologic(175;0.0537)	Breast(109;0.00526)|Lung NSC(97;0.00901)|all_lung(97;0.018)|Medulloblastoma(222;0.0523)|all_neural(223;0.186)		OV - Ovarian serous cystadenocarcinoma(99;0.0167)|Lung(977;0.171)|LUSC - Lung squamous cell carcinoma(976;0.184)		TTTCCTTAACCTTTTTTTTAAG	0.441													8	407	---	---	---	---					
CHD4	1108	broad.mit.edu	37	12	6711207	6711209	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:6711207_6711209delCTT	ENST00000309577.6	-	4	518_520	c.355_357delAAG	c.(355-357)del	p.K119del	CHD4_ENST00000544484.1_In_Frame_Del_p.K116del|CHD4_ENST00000357008.2_In_Frame_Del_p.K119del|CHD4_ENST00000544040.1_In_Frame_Del_p.K112del			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	119	Poly-Lys.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding	p.K119delK(3)		central_nervous_system(2)	2						TAGGTCCAAGCTTCTTCTTCTTC	0.537													9	210	---	---	---	---					
LRRC23	10233	broad.mit.edu	37	12	7015019	7015019	+	Frame_Shift_Del	DEL	C	C	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:7015019delC	ENST00000007969.8	+	3	357	c.137delC	c.(136-138)acfs	p.T46fs	LRRC23_ENST00000323702.5_Frame_Shift_Del_p.T46fs|LRRC23_ENST00000443597.2_Frame_Shift_Del_p.T46fs|LRRC23_ENST00000433346.1_Frame_Shift_Del_p.T46fs|LRRC23_ENST00000449039.1_Intron|LRRC23_ENST00000429740.1_Frame_Shift_Del_p.T46fs|LRRC23_ENST00000436789.1_Frame_Shift_Del_p.T46fs	NM_001135217.1|NM_201650.2	NP_001128689.1|NP_964013.1	Q53EV4	LRC23_HUMAN	leucine rich repeat containing 23	46										NS(1)|breast(1)|endometrium(2)|large_intestine(3)|lung(3)|ovary(1)|prostate(1)|stomach(1)	13						TGGCTGCCCACCCCCCTCACG	0.572													7	410	---	---	---	---					
KLHL42	57542	broad.mit.edu	37	12	27950769	27950769	+	Frame_Shift_Del	DEL	G	G	-	rs145908611	byFrequency	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:27950769delG	ENST00000381271.2	+	3	1499	c.1188delG	c.(1186-1188)gtfs	p.V396fs		NM_020782.1	NP_065833.1			kelch-like family member 42																		TCTACATCGTGGGGGGGTGTC	0.592													9	748	---	---	---	---					
SCAF11	9169	broad.mit.edu	37	12	46318575	46318577	+	In_Frame_Del	DEL	GGT	GGT	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:46318575_46318577delGGT	ENST00000465950.1	-	2	4104_4106	c.2895_2897delACC	c.(2893-2898)ccc>cc	p.PP969del	SCAF11_ENST00000369367.3_In_Frame_Del_p.PP1284del|SCAF11_ENST00000549162.1_In_Frame_Del_p.PP1092del|SCAF11_ENST00000419565.2_In_Frame_Del_p.PP1284del			Q99590	SCAFB_HUMAN	SR-related CTD-associated factor 11	1284	Arg-rich.				spliceosome assembly	nucleus	protein binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(2)|kidney(8)|large_intestine(17)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(3)	69						TGGGGGAGGGGGTGGTGGTGGTG	0.483													8	757	---	---	---	---					
OR10A7	121364	broad.mit.edu	37	12	55615114	55615116	+	In_Frame_Del	DEL	CTT	CTT	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:55615114_55615116delCTT	ENST00000326258.1	+	1	306_308	c.306_308delCTT	c.(304-309)tac>ta	p.YF102del		NM_001005280.1	NP_001005280.1	Q8NGE5	O10A7_HUMAN	olfactory receptor, family 10, subfamily A, member 7	102					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|lung(11)|ovary(4)|prostate(2)|skin(3)	24						CCCAGATGTACTTCTTCTTCTTC	0.414													14	1013	---	---	---	---					
OR6C65	403282	broad.mit.edu	37	12	55794610	55794610	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:55794610delT	ENST00000379665.2	+	1	397	c.298delT	c.(298-300)ttfs	p.F101fs		NM_001005518.1	NP_001005518.1	A6NJZ3	O6C65_HUMAN	olfactory receptor, family 6, subfamily C, member 65	101					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.L102fs*1(1)		cervix(1)|endometrium(2)|large_intestine(3)|lung(9)	15						GGCCCAAGTATTTTTTTTAAT	0.358													7	571	---	---	---	---					
SMARCC2	6601	broad.mit.edu	37	12	56558379	56558381	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:56558379_56558381delAGG	ENST00000550164.1	-	28	3381_3383	c.3367_3369delCCT	c.(3367-3369)del	p.P1123del	RP11-977G19.5_ENST00000553176.1_RNA|SMARCC2_ENST00000267064.4_In_Frame_Del_p.P1092del|SMARCC2_ENST00000394023.3_Intron|SMARCC2_ENST00000347471.4_Intron			Q8TAQ2	SMRC2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	1092	Pro-rich.			HGHHHHLPFA -> MGSPPSPVR (in Ref. 1; AAC50694).	chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(18;0.123)			TGGATGGAGCAGGAGGAGGAGGA	0.591													10	216	---	---	---	---					
MARS	4141	broad.mit.edu	37	12	57883053	57883053	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:57883053delT	ENST00000262027.5	+	3	338	c.204delT	c.(202-204)tafs	p.Y68fs	MARS_ENST00000315473.5_5'UTR|MARS_ENST00000447721.2_Intron	NM_004990.3	NP_004981.2	P56192	SYMC_HUMAN	methionyl-tRNA synthetase	68					methionyl-tRNA aminoacylation	cytosol	ATP binding|methionine-tRNA ligase activity|protein binding|tRNA binding			breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(8)|lung(8)|ovary(3)|pancreas(1)|prostate(2)|skin(1)	33			GBM - Glioblastoma multiforme(3;4.27e-41)		L-Methionine(DB00134)	TGGGCAGATATTTTTTTTTGT	0.488													10	343	---	---	---	---					
B4GALNT1	2583	broad.mit.edu	37	12	58025102	58025103	+	Frame_Shift_Ins	INS	-	-	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:58025102_58025103insC	ENST00000341156.4	-	3	847_848	c.263_264insG	c.(262-264)gctfs	p.A88fs	B4GALNT1_ENST00000449184.3_Frame_Shift_Ins_p.A88fs|B4GALNT1_ENST00000418555.2_Intron|B4GALNT1_ENST00000552350.1_Frame_Shift_Ins_p.A88fs|B4GALNT1_ENST00000550764.1_Frame_Shift_Ins_p.A88fs|B4GALNT1_ENST00000550943.1_Intron	NM_001478.3	NP_001469.1	Q00973	B4GN1_HUMAN	beta-1,4-N-acetyl-galactosaminyl transferase 1	88					lipid glycosylation	integral to Golgi membrane|membrane fraction	(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity	p.G88fs*24(1)		breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(4)|lung(6)|prostate(1)|stomach(1)|urinary_tract(1)	20	Melanoma(17;0.122)		BRCA - Breast invasive adenocarcinoma(9;0.109)			GGAGGGGGAGGCCCCCCCCACT	0.589													14	694	---	---	---	---					
TMPO	7112	broad.mit.edu	37	12	98921671	98921672	+	Frame_Shift_Ins	INS	-	-	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:98921671_98921672insA	ENST00000556029.1	+	2	643_644	c.287_288insA	c.(286-288)aaafs	p.K96fs	TMPO_ENST00000343315.5_Frame_Shift_Ins_p.K96fs|TMPO_ENST00000261210.5_Frame_Shift_Ins_p.K96fs|TMPO_ENST00000266732.4_Frame_Shift_Ins_p.K96fs|TMPO_ENST00000393053.2_Frame_Shift_Ins_p.K96fs	NM_001032283.2	NP_001027454.1	P42167	LAP2B_HUMAN	thymopoietin	96	Linker.|Nucleoplasmic (Potential).					integral to membrane|nuclear inner membrane	DNA binding|lamin binding			breast(2)|endometrium(1)|large_intestine(4)|lung(5)|ovary(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	16						CAGAAAGCCACAAAAAAAACTG	0.332													10	471	---	---	---	---					
CHPT1	56994	broad.mit.edu	37	12	102108337	102108338	+	Frame_Shift_Ins	INS	-	-	T			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:102108337_102108338insT	ENST00000549872.1	+	3	667_668	c.477_478insT	c.(475-480)tgttttfs	p.CF159fs	CHPT1_ENST00000229266.3_Frame_Shift_Ins_p.CF159fs|CHPT1_ENST00000550385.1_3'UTR			Q8WUD6	CHPT1_HUMAN	choline phosphotransferase 1	159					platelet activating factor biosynthetic process|regulation of cell growth	Golgi membrane|integral to membrane|microsome	diacylglycerol binding|diacylglycerol cholinephosphotransferase activity|metal ion binding			kidney(2)|large_intestine(3)|lung(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	10						ATCCTGACTGGTTTTTTTTCTG	0.342													7	287	---	---	---	---					
HVCN1	84329	broad.mit.edu	37	12	111099110	111099112	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:111099110_111099112delCTC	ENST00000356742.5	-	3	916_918	c.163_165delGAG	c.(163-165)del	p.E55del	HVCN1_ENST00000548312.1_In_Frame_Del_p.E55del|HVCN1_ENST00000439744.2_In_Frame_Del_p.E35del|HVCN1_ENST00000242607.8_In_Frame_Del_p.E55del			Q96D96	HVCN1_HUMAN	hydrogen voltage-gated channel 1	55	Poly-Glu.				response to pH|response to zinc ion	integral to membrane	voltage-gated proton channel activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	19						GTGGTGGCTGctcctcctcctcc	0.606													8	289	---	---	---	---					
CUX2	23316	broad.mit.edu	37	12	111758235	111758237	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:111758235_111758237delTCC	ENST00000261726.6	+	17	2576_2578	c.2422_2424delTCC	c.(2422-2424)del	p.S813del		NM_015267.3	NP_056082.2	O14529	CUX2_HUMAN	cut-like homeobox 2	813	Poly-Ser.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|lung(24)|ovary(5)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	55						GCCCTCGCTGTCCTCCTCCTCCT	0.749													9	262	---	---	---	---					
POP5	51367	broad.mit.edu	37	12	121017154	121017156	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:121017154_121017156delCTC	ENST00000341039.2	-	4	323_325	c.307_309delGAG	c.(307-309)del	p.E103del	POP5_ENST00000542776.1_5'UTR|POP5_ENST00000357500.4_In_Frame_Del_p.E153del	NM_198202.1	NP_937845.1	Q969H6	POP5_HUMAN	processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)	153					tRNA processing		protein binding|ribonuclease P activity			breast(1)|endometrium(1)|large_intestine(2)|lung(2)|ovary(1)	7	all_neural(191;0.077)|Medulloblastoma(191;0.0922)					CCTCACCTGACTCCTCCTCCTCC	0.517													10	761	---	---	---	---					
DDX55	57696	broad.mit.edu	37	12	124103201	124103202	+	Translation_Start_Site	DEL	TG	TG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:124103201_124103202delTG	ENST00000421670.3	+	0	639_640				DDX55_ENST00000541259.1_Intron|DDX55_ENST00000538744.1_Intron|DDX55_ENST00000238146.4_Intron			Q8NHQ9	DDX55_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 55								ATP binding|ATP-dependent helicase activity|RNA binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|large_intestine(3)|liver(1)|lung(4)|ovary(1)|prostate(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000142)|Epithelial(86;0.000637)|all cancers(50;0.00772)		GAATGTGGTATGTGTGTGTGTG	0.520											OREG0022230	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	17	284	---	---	---	---					
NCOR2	9612	broad.mit.edu	37	12	124848228	124848228	+	Frame_Shift_Del	DEL	G	G	-	rs12321697		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr12:124848228delG	ENST00000356219.3	-	22	3080	c.2925delC	c.(2923-2925)ccfs	p.P975fs	NCOR2_ENST00000404121.2_Frame_Shift_Del_p.P528fs|NCOR2_ENST00000397355.1_Frame_Shift_Del_p.P958fs|NCOR2_ENST00000405201.1_Frame_Shift_Del_p.P975fs|NCOR2_ENST00000429285.2_Frame_Shift_Del_p.P957fs|NCOR2_ENST00000404621.1_Frame_Shift_Del_p.P957fs	NM_006312.5	NP_006303.4	Q9Y618	NCOR2_HUMAN	nuclear receptor corepressor 2	975					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			breast(5)|central_nervous_system(2)|endometrium(7)|kidney(5)|large_intestine(7)|lung(28)|ovary(3)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	69	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		CACTCACGATGGGGGGGATGG	0.652													8	1020	---	---	---	---					
HSPH1	10808	broad.mit.edu	37	13	31715381	31715382	+	Frame_Shift_Ins	INS	-	-	T			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr13:31715381_31715382insT	ENST00000320027.5	-	13	2075_2076	c.1731_1732insA	c.(1729-1734)aattgafs	p.N*577fs	HSPH1_ENST00000380405.4_Frame_Shift_Ins_p.N*533fs|HSPH1_ENST00000380406.5_Frame_Shift_Ins_p.N*536fs|HSPH1_ENST00000429785.2_Frame_Shift_Ins_p.N*396fs|HSPH1_ENST00000445273.2_Frame_Shift_Ins_p.N*579fs	NM_006644.2	NP_006635.2	Q92598	HS105_HUMAN	heat shock 105kDa/110kDa protein 1	577					positive regulation of MHC class I biosynthetic process|positive regulation of NK T cell activation|response to unfolded protein	cytoplasm|extracellular region	ATP binding			breast(1)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(4)|lung(7)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	27		Lung SC(185;0.0257)		all cancers(112;0.00385)|Epithelial(112;0.0328)|OV - Ovarian serous cystadenocarcinoma(117;0.0375)|GBM - Glioblastoma multiforme(144;0.125)		GGCTGGTCAACTTTTTTTTCAT	0.376													9	434	---	---	---	---					
ZC3H13	23091	broad.mit.edu	37	13	46549613	46549614	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr13:46549613_46549614delCT	ENST00000242848.4	-	12	2620_2621	c.2272_2273delAG	c.(2272-2274)gfs	p.R758fs	ZC3H13_ENST00000282007.3_Frame_Shift_Del_p.R758fs			Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	758	Arg/Glu-rich.						nucleic acid binding|zinc ion binding			cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(27)|lung(25)|ovary(2)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	79		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		ctctctctccctctctctctct	0.530													7	180	---	---	---	---					
LRCH1	23143	broad.mit.edu	37	13	47243183	47243186	+	Frame_Shift_Del	DEL	CCTG	CCTG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr13:47243183_47243186delCCTG	ENST00000311191.6	+	3	700_703	c.471_474delCCTG	c.(469-474)gcfs	p.AL157fs	LRCH1_ENST00000389798.3_Frame_Shift_Del_p.AL157fs|LRCH1_ENST00000389797.3_Frame_Shift_Del_p.AL157fs	NM_001164213.1	NP_001157685.1	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH) domain containing 1	157										breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|kidney(3)|large_intestine(3)|lung(11)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	26		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		AGCTGTCCGCCCTGCCTGCCTGCC	0.436													7	954	---	---	---	---					
ABCC4	10257	broad.mit.edu	37	13	95696016	95696016	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr13:95696016delT	ENST00000376887.4	-	29	3769	c.3655delA	c.(3655-3657)tcfs	p.I1219fs	ABCC4_ENST00000412704.1_Frame_Shift_Del_p.I1172fs	NM_005845.3	NP_005836.2	O15439	MRP4_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	1219	ABC transporter 2.				platelet activation|platelet degranulation	integral to membrane|membrane fraction|plasma membrane|platelet dense granule membrane	15-hydroxyprostaglandin dehydrogenase (NAD+) activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|chloride channel activity			breast(1)|central_nervous_system(4)|endometrium(5)|kidney(4)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(4)|urinary_tract(1)	43	all_neural(89;0.0878)|Medulloblastoma(90;0.163)				Cefazolin(DB01327)	TTCTCCCGGATTTTTTTTTGT	0.378													18	491	---	---	---	---					
TEP1	7011	broad.mit.edu	37	14	20852647	20852647	+	Frame_Shift_Del	DEL	C	C	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr14:20852647delC	ENST00000262715.5	-	23	3282	c.3242delG	c.(3241-3243)gtfs	p.G1081fs	TEP1_ENST00000556935.1_Frame_Shift_Del_p.G973fs	NM_007110.4	NP_009041.2	Q99973	TEP1_HUMAN	telomerase-associated protein 1	1081					telomere maintenance via recombination	chromosome, telomeric region|cytoplasm|nuclear matrix|soluble fraction|telomerase holoenzyme complex	ATP binding|RNA binding	p.V1082fs*47(1)		NS(4)|breast(1)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(9)|lung(48)|ovary(7)|pancreas(1)|prostate(2)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	96	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;7.42e-08)|all cancers(55;6.46e-07)	GBM - Glioblastoma multiforme(265;0.028)|READ - Rectum adenocarcinoma(17;0.233)		AGCTGCCACACCCCCCCACTC	0.587													7	1311	---	---	---	---					
LTB4R	1241	broad.mit.edu	37	14	24785074	24785074	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr14:24785074delT	ENST00000396789.4	+	2	1942	c.217delT	c.(217-219)ttfs	p.F74fs	LTB4R_ENST00000396782.2_Frame_Shift_Del_p.F74fs|LTB4R_ENST00000345363.3_Frame_Shift_Del_p.F74fs	NM_181657.3	NP_858043.1	Q15722	LT4R1_HUMAN	leukotriene B4 receptor	74					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cellular component movement|immune response|inflammatory response|muscle contraction	integral to plasma membrane	nucleotide binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(3)|stomach(1)	8				GBM - Glioblastoma multiforme(265;0.018)		CACTGCTCCCTTTTTCCTTCA	0.582													7	798	---	---	---	---					
MGAT2	4247	broad.mit.edu	37	14	50088320	50088321	+	Frame_Shift_Ins	INS	-	-	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr14:50088320_50088321insC	ENST00000305386.2	+	1	832_833	c.334_335insC	c.(334-336)ctgfs	p.L112fs	RP11-649E7.5_ENST00000555043.1_RNA	NM_002408.3	NP_002399.1	Q10469	MGAT2_HUMAN	mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase	112					oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity			cervix(1)|endometrium(3)|large_intestine(1)|lung(6)	11	all_epithelial(31;0.0021)|Breast(41;0.0124)					TAAGGCTGGCACCTGGGCCCCC	0.614													12	830	---	---	---	---					
RBM25	58517	broad.mit.edu	37	14	73572607	73572608	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr14:73572607_73572608delAG	ENST00000261973.7	+	11	1480_1481	c.1195_1196delAG	c.(1195-1197)afs	p.R399fs	RBM25_ENST00000527432.1_Frame_Shift_Del_p.R399fs	NM_021239.2	NP_067062.1	P49756	RBM25_HUMAN	RNA binding motif protein 25	399	Arg-rich.|Glu-rich.|Necessary for nuclear speckle localization.				apoptosis|mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome|RNA splicing	cytoplasm|nuclear speck	mRNA binding|nucleotide binding|protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(7)|lung(6)|ovary(2)|pancreas(1)	31				BRCA - Breast invasive adenocarcinoma(234;0.00362)|OV - Ovarian serous cystadenocarcinoma(108;0.0688)		agagcgggaaagagagagagag	0.446													8	127	---	---	---	---					
VRTN	55237	broad.mit.edu	37	14	74824462	74824463	+	Frame_Shift_Ins	INS	-	-	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr14:74824462_74824463insG	ENST00000256362.4	+	2	1217_1218	c.976_977insG	c.(976-978)gggfs	p.G326fs		NM_018228.2	NP_060698.2	Q9H8Y1	VRTN_HUMAN	vertebrae development associated	326					transposition, DNA-mediated		DNA binding|transposase activity	p.V329fs*25(1)		NS(1)|autonomic_ganglia(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(10)|lung(15)|ovary(5)|prostate(2)|skin(1)|urinary_tract(1)	41						CAGCTTCCACCGGGGGGGCGTC	0.644													7	643	---	---	---	---					
DDX24	57062	broad.mit.edu	37	14	94545821	94545823	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr14:94545821_94545823delCCT	ENST00000330836.5	-	2	397_399	c.266_268delAGG	c.(265-270)gga>g	p.EG89del	DDX24_ENST00000544005.1_Intron|DDX24_ENST00000555054.1_In_Frame_Del_p.EG46del	NM_020414.3	NP_065147.1	Q9GZR7	DDX24_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 24	89	Poly-Glu.				RNA metabolic process	cytoplasm|nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			cervix(3)|endometrium(4)|kidney(4)|large_intestine(5)|lung(3)|ovary(2)|skin(1)|urinary_tract(1)	23		all_cancers(154;0.12)		Epithelial(152;0.114)|all cancers(159;0.19)|COAD - Colon adenocarcinoma(157;0.207)		CTAGACTTTCCCTCCTCCTCCTC	0.443													11	731	---	---	---	---					
SYNE3	161176	broad.mit.edu	37	14	95921888	95921890	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr14:95921888_95921890delCTC	ENST00000334258.5	-	5	975_977	c.961_963delGAG	c.(961-963)del	p.E321del	SYNE3_ENST00000553340.1_In_Frame_Del_p.E321del|SYNE3_ENST00000557275.1_In_Frame_Del_p.E321del|SYNE3_ENST00000554873.1_In_Frame_Del_p.E78del	NM_152592.3	NP_689805.3			spectrin repeat containing, nuclear envelope family member 3											breast(1)|endometrium(2)|lung(25)	28						CCCGCAGCCGCTCCTCCTCCTCC	0.616													7	605	---	---	---	---					
HSP90AA1	3320	broad.mit.edu	37	14	102551161	102551163	+	In_Frame_Del	DEL	TCT	TCT	-	rs55793809	byFrequency	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr14:102551161_102551163delTCT	ENST00000334701.7	-	6	1483_1485	c.1202_1204delAGA	c.(1201-1206)att>a	p.KI401del	HSP90AA1_ENST00000441629.2_In_Frame_Del_p.KI100del|HSP90AA1_ENST00000216281.8_In_Frame_Del_p.KI279del	NM_001017963.2	NP_001017963.2	P07900	HS90A_HUMAN	heat shock protein 90kDa alpha (cytosolic), class A member 1	279					axon guidance|cellular chaperone-mediated protein complex assembly|G2/M transition of mitotic cell cycle|nitric oxide metabolic process|positive regulation of nitric oxide biosynthetic process|protein import into mitochondrial outer membrane|protein refolding|regulation of nitric-oxide synthase activity|response to unfolded protein|signal transduction	cytosol|melanosome|plasma membrane	ATP binding|ATPase activity|nitric-oxide synthase regulator activity|protein homodimerization activity|TPR domain binding|unfolded protein binding			breast(1)|central_nervous_system(2)|endometrium(2)|kidney(6)|large_intestine(3)|liver(1)|lung(10)|ovary(2)|prostate(1)	28					Rifabutin(DB00615)	ttttccttaatcttcttcttctt	0.389													7	222	---	---	---	---					
IGHJ6	0	broad.mit.edu	37	14	106329451	106329453	+	RNA	DEL	GTA	GTA	-	rs2338628		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr14:106329451_106329453delGTA	ENST00000390560.2	-	0	15_17																											AGACGTCCATGTAGTAGTAGTAG	0.537													7	660	---	---	---	---					
IGHV3-21	0	broad.mit.edu	37	14	106691799	106691801	+	RNA	DEL	ACT	ACT	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr14:106691799_106691801delACT	ENST00000390607.2	-	0	301_303																											AGTATATGTAACTACTACTACTA	0.517													8	1324	---	---	---	---					
EMC7	56851	broad.mit.edu	37	15	34393991	34393993	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr15:34393991_34393993delAGC	ENST00000256545.4	-	1	156_158	c.48_50delGCT	c.(46-51)cta>ct	p.LL16del	EMC7_ENST00000532113.1_5'UTR	NM_020154.2	NP_064539.1			ER membrane protein complex subunit 7																		ATCCCCCGATAGCAGCAGCAGCA	0.665													13	816	---	---	---	---					
EIF2AK4	440275	broad.mit.edu	37	15	40282508	40282508	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr15:40282508delT	ENST00000263791.5	+	16	2604	c.2561delT	c.(2560-2562)atfs	p.I854fs	EIF2AK4_ENST00000382727.2_Frame_Shift_Del_p.I826fs	NM_001013703.2	NP_001013725.2	Q9P2K8	E2AK4_HUMAN	eukaryotic translation initiation factor 2 alpha kinase 4	854	Protein kinase 2.				translation	cytosolic ribosome	aminoacyl-tRNA ligase activity|ATP binding|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)	40		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		CCTGTCAACATTTTTTTGGAT	0.358													9	1511	---	---	---	---					
TTBK2	146057	broad.mit.edu	37	15	43038023	43038024	+	Frame_Shift_Ins	INS	-	-	T			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr15:43038023_43038024insT	ENST00000267890.6	-	15	3812_3813	c.3704_3705insA	c.(3703-3705)aagfs	p.K1235fs		NM_173500.3	NP_775771.3	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	1235					cell death		ATP binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	43		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		CTGGCTTACTCTTCCCTTGGGG	0.535													12	1004	---	---	---	---					
TTBK2	146057	broad.mit.edu	37	15	43038025	43038026	+	Frame_Shift_Ins	INS	-	-	C			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr15:43038025_43038026insC	ENST00000267890.6	-	15	3810_3811	c.3702_3703insG	c.(3700-3705)ggagagfs	p.E1235fs		NM_173500.3	NP_775771.3	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	1235					cell death		ATP binding|protein serine/threonine kinase activity			NS(1)|cervix(2)|endometrium(4)|kidney(2)|large_intestine(8)|lung(17)|ovary(2)|pancreas(1)|prostate(1)|skin(3)|stomach(2)	43		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		GGCTTACTCTTCCCTTGGGGGG	0.540													22	1016	---	---	---	---					
SPG11	80208	broad.mit.edu	37	15	44907750	44907750	+	Frame_Shift_Del	DEL	A	A	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr15:44907750delA	ENST00000261866.7	-	16	2865	c.2849delT	c.(2848-2850)tgfs	p.L950fs	SPG11_ENST00000558319.1_Frame_Shift_Del_p.L950fs|SPG11_ENST00000535302.2_Frame_Shift_Del_p.L950fs|SPG11_ENST00000427534.2_Frame_Shift_Del_p.L950fs	NM_025137.3	NP_079413.3	Q96JI7	SPTCS_HUMAN	spastic paraplegia 11 (autosomal recessive)	950					cell death	cytosol|integral to membrane|nucleus	protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(4)|large_intestine(16)|lung(24)|ovary(5)|prostate(3)|skin(3)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	72		all_cancers(109;1.29e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;1.34e-07)|all_lung(180;1.21e-06)|Melanoma(134;0.0122)		all cancers(107;2.93e-22)|GBM - Glioblastoma multiforme(94;1.55e-06)|COAD - Colon adenocarcinoma(120;0.0432)|Colorectal(105;0.0484)|Lung(196;0.104)|LUSC - Lung squamous cell carcinoma(244;0.214)		TTCAGATGCCAAAAAAACCCC	0.403													10	338	---	---	---	---					
WDR72	256764	broad.mit.edu	37	15	53992038	53992038	+	Frame_Shift_Del	DEL	A	A	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr15:53992038delA	ENST00000396328.1	-	13	1913	c.1674delT	c.(1672-1674)ttfs	p.F558fs	WDR72_ENST00000559418.1_Frame_Shift_Del_p.F568fs|WDR72_ENST00000360509.5_Frame_Shift_Del_p.F558fs|WDR72_ENST00000557913.1_Frame_Shift_Del_p.F555fs	NM_001277176.1|NM_182758.2	NP_001264105.1|NP_877435.3	Q3MJ13	WDR72_HUMAN	WD repeat domain 72	558										NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(18)|lung(29)|prostate(3)|skin(6)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	71				all cancers(107;0.0511)		TCCTCACAGGAAAAAGGTGCT	0.463													7	1110	---	---	---	---					
SLTM	79811	broad.mit.edu	37	15	59186041	59186041	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr15:59186041delT	ENST00000380516.2	-	12	1714	c.1627delA	c.(1627-1629)gtfs	p.S543fs	AC025918.2_ENST00000452467.1_RNA|SLTM_ENST00000536328.1_Frame_Shift_Del_p.S112fs	NM_001013843.1|NM_024755.2	NP_001013865.1|NP_079031.2	Q9NWH9	SLTM_HUMAN	SAFB-like, transcription modulator	543					apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	28						TTTTCTTCACTTTTTTTAATC	0.313													7	614	---	---	---	---					
SLC24A1	9187	broad.mit.edu	37	15	65943128	65943130	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr15:65943128_65943130delGAG	ENST00000261892.6	+	7	2928_2930	c.2641_2643delGAG	c.(2641-2643)del	p.E890del	SLC24A1_ENST00000399033.4_In_Frame_Del_p.E890del|SLC24A1_ENST00000339868.6_In_Frame_Del_p.E872del|SLC24A1_ENST00000537259.1_In_Frame_Del_p.E872del|SLC24A1_ENST00000449142.2_3'UTR|SLC24A1_ENST00000546330.1_In_Frame_Del_p.E872del|SLC24A1_ENST00000544319.2_In_Frame_Del_p.E776del	NM_001254740.1|NM_004727.2	NP_001241669.1|NP_004718.1	O60721	NCKX1_HUMAN	solute carrier family 24 (sodium/potassium/calcium exchanger), member 1	890	Poly-Glu.				response to light intensity|visual perception	integral to plasma membrane|membrane fraction|outer membrane	calcium, potassium:sodium antiporter activity|protein binding|symporter activity			breast(2)|endometrium(7)|kidney(1)|large_intestine(4)|lung(6)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	23						gcaggaggaagaggaggaggagg	0.562													10	150	---	---	---	---					
CHD2	1106	broad.mit.edu	37	15	93540315	93540316	+	Frame_Shift_Ins	INS	-	-	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr15:93540315_93540316insA	ENST00000394196.4	+	29	4792_4793	c.3724_3725insA	c.(3724-3726)aaafs	p.K1242fs	CHD2_ENST00000557381.1_Frame_Shift_Ins_p.K1242fs	NM_001271.3	NP_001262.3	O14647	CHD2_HUMAN	chromodomain helicase DNA binding protein 2	1242					regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding			breast(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(5)|kidney(2)|large_intestine(10)|lung(17)|ovary(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	47	Lung NSC(78;0.00976)|all_lung(78;0.016)		BRCA - Breast invasive adenocarcinoma(143;0.0282)|OV - Ovarian serous cystadenocarcinoma(32;0.0814)			GGACCCTGAAGAAAAAAAAAAG	0.347													24	416	---	---	---	---					
CREBBP	1387	broad.mit.edu	37	16	3817721	3817721	+	Splice_Site	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr16:3817721delT	ENST00000262367.5	-	16	4059	c.3250_splice	c.e16+1	p.I1084_splice	CREBBP_ENST00000382070.3_Splice_Site_p.I1046_splice	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	1084					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		AATGGCCTACTTTTTTTGCGC	0.398			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						7	586	---	---	---	---					
NTAN1	123803	broad.mit.edu	37	16	15131931	15131931	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr16:15131931delT	ENST00000287706.3	-	10	982	c.890delA	c.(889-891)atfs	p.N297fs	PDXDC1_ENST00000535621.2_Intron	NM_173474.2	NP_775745.1	Q96AB6	NTAN1_HUMAN	N-terminal asparagine amidase	297						cytoplasm				endometrium(1)|large_intestine(4)|lung(3)	8						GCCATCTTCATTTTTTTTGTA	0.383													10	640	---	---	---	---					
C16orf62	57020	broad.mit.edu	37	16	19580800	19580802	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr16:19580800_19580802delTCC	ENST00000438132.3	+	3	487_489	c.439_441delTCC	c.(439-441)del	p.S153del	C16orf62_ENST00000538853.1_In_Frame_Del_p.S153del|C16orf62_ENST00000542263.1_In_Frame_Del_p.S153del|C16orf62_ENST00000417362.2_In_Frame_Del_p.S64del|C16orf62_ENST00000251143.5_In_Frame_Del_p.S64del	NM_020314.5	NP_064710.4	Q7Z3J2	CP062_HUMAN	chromosome 16 open reading frame 62	64						integral to membrane				breast(2)|central_nervous_system(1)|endometrium(3)|kidney(5)|large_intestine(7)|liver(1)|lung(11)|ovary(1)|prostate(2)|skin(1)|urinary_tract(2)	36						TTCTTCCACGTCCTCCTCCTCCT	0.562													14	348	---	---	---	---					
EIF3C	8663	broad.mit.edu	37	16	28734579	28734581	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr16:28734579_28734581delGAG	ENST00000331666.6	+	9	1057_1059	c.871_873delGAG	c.(871-873)del	p.E294del	EIF3C_ENST00000566501.1_In_Frame_Del_p.E294del|EIF3C_ENST00000395587.1_In_Frame_Del_p.E294del|EIF3C_ENST00000566866.1_In_Frame_Del_p.E294del|EIF3C_ENST00000564243.1_In_Frame_Del_p.E284del			Q99613	EIF3C_HUMAN	eukaryotic translation initiation factor 3, subunit C	294	Poly-Glu.					cytosol|eukaryotic translation initiation factor 3 complex	protein binding|translation initiation factor activity			lung(5)|skin(1)	6						GCGCCTGGATGAGGAGGAGGAGG	0.562													10	3588	---	---	---	---					
TAOK2	9344	broad.mit.edu	37	16	29994531	29994533	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr16:29994531_29994533delGAG	ENST00000308893.4	+	12	2181_2183	c.1138_1140delGAG	c.(1138-1140)del	p.E392del	TAOK2_ENST00000416441.2_In_Frame_Del_p.E219del|TAOK2_ENST00000279394.3_In_Frame_Del_p.E392del|TAOK2_ENST00000543033.1_In_Frame_Del_p.E392del	NM_001252043.1|NM_016151.3	NP_001238972.1|NP_057235.2	Q9UL54	TAOK2_HUMAN	TAO kinase 2	392	Glu-rich.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(3)|skin(1)	22						CAACgaggaagaggaggaggagg	0.611													8	295	---	---	---	---					
TAOK2	9344	broad.mit.edu	37	16	29998498	29998500	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr16:29998498_29998500delCTG	ENST00000308893.4	+	16	3948_3950	c.2905_2907delCTG	c.(2905-2907)del	p.L974del	TAOK2_ENST00000416441.2_In_Frame_Del_p.L801del|TAOK2_ENST00000279394.3_Intron|TAOK2_ENST00000543033.1_In_Frame_Del_p.L861del	NM_001252043.1|NM_016151.3	NP_001238972.1|NP_057235.2	Q9UL54	TAOK2_HUMAN	TAO kinase 2	974	Leu-rich.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			breast(1)|endometrium(3)|large_intestine(5)|lung(8)|ovary(1)|prostate(3)|skin(1)	22						CCTGCCCCTCCTGCTGCTGCTGC	0.709													7	355	---	---	---	---					
SRCAP	10847	broad.mit.edu	37	16	30736314	30736314	+	Frame_Shift_Del	DEL	C	C	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr16:30736314delC	ENST00000262518.4	+	25	5954	c.5569delC	c.(5569-5571)ccfs	p.P1858fs	SRCAP_ENST00000395059.2_Frame_Shift_Del_p.P1796fs|SRCAP_ENST00000344771.4_Frame_Shift_Del_p.P1700fs	NM_006662.2	NP_006653.2	Q6ZRS2	SRCAP_HUMAN	Snf2-related CREBBP activator protein	1858	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			GCGCTCTGGTCCCCCCAGCCC	0.612													7	1197	---	---	---	---					
RP11-51O6.1	0	broad.mit.edu	37	16	61089302	61089302	+	RNA	DEL	C	C	-	rs80101907		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr16:61089302delC	ENST00000591758.1	-	0	566																											GCttcttcttctttttttttt	0.244													25	84	---	---	---	---					
NOB1	28987	broad.mit.edu	37	16	69782978	69782980	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr16:69782978_69782980delTCC	ENST00000268802.5	-	6	596_598	c.567_569delGGA	c.(565-570)gaa>ga	p.EE189del		NM_014062.1	NP_054781.1	Q9ULX3	NOB1_HUMAN	NIN1/RPN12 binding protein 1 homolog (S. cerevisiae)	189	Poly-Glu.					nucleus	metal ion binding|protein binding			breast(2)|cervix(1)|endometrium(1)|large_intestine(1)|lung(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	11						CCCGTTTTCTTCCTCCTCCTCCT	0.522													18	533	---	---	---	---					
ITGAE	3682	broad.mit.edu	37	17	3664312	3664314	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr17:3664312_3664314delTCC	ENST00000263087.4	-	6	689_691	c.591_593delGGA	c.(589-594)gaa>ga	p.EE197del		NM_002208.4	NP_002199.3	P38570	ITAE_HUMAN	integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)	197	Glu-rich (acidic).|X-domain (extra domain).				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		CTCACCAGCTtcctcctcctcct	0.586													7	347	---	---	---	---					
EPN2	22905	broad.mit.edu	37	17	19232950	19232950	+	Frame_Shift_Del	DEL	A	A	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr17:19232950delA	ENST00000314728.5	+	9	1885	c.1401delA	c.(1399-1401)tcfs	p.S467fs	EPN2_ENST00000395626.1_Frame_Shift_Del_p.S467fs|EPN2_ENST00000395618.3_Frame_Shift_Del_p.S182fs|EPN2_ENST00000347697.2_Frame_Shift_Del_p.S410fs|EPN2_ENST00000575595.1_Frame_Shift_Del_p.S175fs|EPN2_ENST00000395620.2_Frame_Shift_Del_p.S410fs|EPN2_ENST00000571254.1_Frame_Shift_Del_p.S403fs	NM_014964.4	NP_055779.2	O95208	EPN2_HUMAN	epsin 2	467	6 X 3 AA repeats of [DE]-P-W.				endocytosis		lipid binding	p.T470fs*19(1)		breast(2)|endometrium(1)|kidney(3)|large_intestine(4)|lung(5)|prostate(1)|skin(2)|urinary_tract(1)	19	all_cancers(12;3.11e-05)|all_epithelial(12;0.00121)|Hepatocellular(7;0.00345)|Breast(13;0.143)					TTCGGACTTCAAAAAAAACAG	0.393													10	475	---	---	---	---					
SUPT6H	6830	broad.mit.edu	37	17	27001303	27001305	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr17:27001303_27001305delGAG	ENST00000314616.6	+	3	395_397	c.112_114delGAG	c.(112-114)del	p.E43del	SUPT6H_ENST00000347486.4_In_Frame_Del_p.E43del	NM_003170.3	NP_003161.2	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog (S. cerevisiae)	43	Asp/Glu-rich.				chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	Lung NSC(42;0.00431)					TCTTCCAGATGAGGAGGAGGAGG	0.453													9	291	---	---	---	---					
SUPT6H	6830	broad.mit.edu	37	17	27027202	27027204	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr17:27027202_27027204delAGC	ENST00000314616.6	+	34	4856_4858	c.4573_4575delAGC	c.(4573-4575)del	p.S1528del	SUPT6H_ENST00000347486.4_In_Frame_Del_p.S1528del	NM_003170.3	NP_003161.2	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog (S. cerevisiae)	1528	Poly-Ser.				chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			NS(4)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(15)|lung(21)|ovary(3)|prostate(1)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	64	Lung NSC(42;0.00431)					CATCACCCCTAGCAGCAGCAGCA	0.537													35	1379	---	---	---	---					
RP11-156P1.3	0	broad.mit.edu	37	17	45128628	45128629	+	RNA	INS	-	-	T			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr17:45128628_45128629insT	ENST00000575173.1	-	0	418																											ATTCTGGTGTGtttttttttgt	0.337													8	223	---	---	---	---					
HOXB2	3212	broad.mit.edu	37	17	46622130	46622132	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr17:46622130_46622132delAGG	ENST00000330070.4	-	1	1309_1311	c.142_144delCCT	c.(142-144)del	p.P48del	HOXB-AS1_ENST00000435312.1_RNA|HOXB-AS1_ENST00000504972.3_RNA	NM_002145.3	NP_002136.1	P14652	HXB2_HUMAN	homeobox B2	48					blood circulation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(5)|prostate(1)|skin(1)	11						TTTGCTCGAAAGGAGGAGGAGGA	0.596													8	455	---	---	---	---					
BZRAP1	9256	broad.mit.edu	37	17	56387404	56387406	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr17:56387404_56387406delTCC	ENST00000355701.3	-	21	4683_4685	c.3813_3815delGGA	c.(3811-3816)gaa>ga	p.EE1273del	BZRAP1_ENST00000343736.4_In_Frame_Del_p.EE1273del|BZRAP1_ENST00000268893.6_In_Frame_Del_p.EE1213del	NM_001261835.1|NM_004758.3	NP_001248764.1|NP_004749.2	O95153	RIMB1_HUMAN	benzodiazapine receptor (peripheral) associated protein 1	1273	Poly-Glu.					mitochondrion	benzodiazepine receptor binding			cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|liver(2)|lung(16)|ovary(1)|prostate(1)|skin(6)|upper_aerodigestive_tract(2)|urinary_tract(1)	54	Medulloblastoma(34;0.127)|all_neural(34;0.237)					CAGctcctcttcctcctcctcct	0.586													7	396	---	---	---	---					
FTSJ3	117246	broad.mit.edu	37	17	61899155	61899157	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr17:61899155_61899157delCTC	ENST00000427159.2	-	15	2167_2169	c.1522_1524delGAG	c.(1522-1524)del	p.E508del		NM_017647.3	NP_060117.3	Q8IY81	RRMJ3_HUMAN	FtsJ homolog 3 (E. coli)	508					RNA methylation|rRNA processing	nucleolus	methyltransferase activity|nucleic acid binding			breast(2)|central_nervous_system(1)|endometrium(6)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	27						GCAGTGGATTCTCCTCCTCCTCC	0.537													13	978	---	---	---	---					
TEX2	55852	broad.mit.edu	37	17	62291438	62291440	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr17:62291438_62291440delTCC	ENST00000258991.3	-	2	222_224	c.138_140delGGA	c.(136-141)gaa>ga	p.EE50del	TEX2_ENST00000583097.1_In_Frame_Del_p.EE50del|TEX2_ENST00000584379.1_In_Frame_Del_p.EE50del			Q8IWB9	TEX2_HUMAN	testis expressed 2	50	Poly-Glu.				signal transduction|sphingolipid metabolic process	integral to membrane				breast(3)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(15)|ovary(1)|pancreas(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		ctcctcctcttcctcctcctcct	0.552													7	454	---	---	---	---					
AMZ2P1	0	broad.mit.edu	37	17	62968575	62968575	+	RNA	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr17:62968575delT	ENST00000430983.1	-	0	1593					NR_026903.1																						TTGGTTGGAATTTTTTTCCCT	0.333													7	238	---	---	---	---					
LRRC37A16P	0	broad.mit.edu	37	17	66141017	66141017	+	RNA	DEL	C	C	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr17:66141017delC	ENST00000590019.1	-	0	70																											AAGATTTCTACAAAAAAAAAA	0.323													7	205	---	---	---	---					
CD300A	11314	broad.mit.edu	37	17	72469708	72469709	+	Frame_Shift_Ins	INS	-	-	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr17:72469708_72469709insG	ENST00000360141.3	+	2	362_363	c.74_75insG	c.(73-75)gggfs	p.G25fs	CD300A_ENST00000310828.5_Intron|CD300A_ENST00000577511.1_5'UTR|CD300A_ENST00000392625.3_Intron|CD300A_ENST00000361933.3_Intron	NM_001256841.1|NM_007261.3	NP_001243770.1|NP_009192.2	Q9UGN4	CLM8_HUMAN	CD300a molecule	25	Ig-like V-type.				cell adhesion	integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(4)|urinary_tract(1)	16						AGGACCGTGGCGGGCCCCGTGG	0.569													12	710	---	---	---	---					
CD300A	11314	broad.mit.edu	37	17	72469711	72469712	+	Frame_Shift_Ins	INS	-	-	GC			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr17:72469711_72469712insGC	ENST00000360141.3	+	2	365_366	c.77_78insGC	c.(76-78)gccfs	p.A26fs	CD300A_ENST00000310828.5_Intron|CD300A_ENST00000577511.1_5'UTR|CD300A_ENST00000392625.3_Intron|CD300A_ENST00000361933.3_Intron	NM_001256841.1|NM_007261.3	NP_001243770.1|NP_009192.2	Q9UGN4	CLM8_HUMAN	CD300a molecule	26	Ig-like V-type.				cell adhesion	integral to membrane|plasma membrane	receptor activity			breast(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|skin(4)|urinary_tract(1)	16						ACCGTGGCGGGCCCCGTGGGGG	0.569													13	682	---	---	---	---					
GGA3	23163	broad.mit.edu	37	17	73239175	73239175	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr17:73239175delT	ENST00000245541.6	-	6	713	c.497delA	c.(496-498)acfs	p.N166fs	GGA3_ENST00000578348.1_Frame_Shift_Del_p.N44fs|GGA3_ENST00000582717.1_Frame_Shift_Del_p.N94fs|GGA3_ENST00000582486.1_Frame_Shift_Del_p.N94fs|GGA3_ENST00000351904.7_Frame_Shift_Del_p.N133fs|GGA3_ENST00000538886.1_Frame_Shift_Del_p.N44fs|GGA3_ENST00000537686.1_Intron	NM_138619.2	NP_619525.1	Q9NZ52	GGA3_HUMAN	golgi-associated, gamma adaptin ear containing, ARF binding protein 3	166	Binds to ARF1 (in long isoform).				intracellular protein transport|vesicle-mediated transport	clathrin adaptor complex|endosome membrane|trans-Golgi network	ADP-ribosylation factor binding			breast(2)|endometrium(3)|large_intestine(4)|liver(1)|lung(4)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	20			all cancers(21;2.39e-06)|Epithelial(20;2.38e-05)			AAAAACAGGGTTTTTGGGACG	0.542													8	882	---	---	---	---					
SEH1L	81929	broad.mit.edu	37	18	12986927	12986929	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr18:12986927_12986929delTCC	ENST00000399892.2	+	9	1238_1240	c.1137_1139delTCC	c.(1135-1140)ctt>ct	p.LP379del	RP11-773H22.4_ENST00000588211.1_RNA|SEH1L_ENST00000262124.11_3'UTR	NM_001013437.1	NP_001013455.1	Q96EE3	SEH1_HUMAN	SEH1-like (S. cerevisiae)	0					attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|carbohydrate metabolic process|cell division|glucose transport|mitotic metaphase plate congression|mitotic prometaphase|mRNA transport|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex				central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(5)|pancreas(1)|prostate(1)	11						CCCAGCTCCTtcctcctcctcct	0.522													12	286	---	---	---	---					
HAUS1	115106	broad.mit.edu	37	18	43685174	43685174	+	Frame_Shift_Del	DEL	A	A	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr18:43685174delA	ENST00000282058.6	+	2	125	c.45delA	c.(43-45)ttfs	p.L15fs	HAUS1_ENST00000585518.1_Frame_Shift_Del_p.L15fs	NM_138443.3	NP_612452.1	Q96CS2	HAUS1_HUMAN	HAUS augmin-like complex, subunit 1	15					cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle pole				endometrium(1)|kidney(1)|large_intestine(2)|lung(2)|ovary(1)	7						CTGCGTGGTTAAAAAAAATAT	0.393													7	240	---	---	---	---					
CXXC1	30827	broad.mit.edu	37	18	47812275	47812277	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr18:47812275_47812277delCTG	ENST00000285106.6	-	5	1195_1197	c.481_483delCAG	c.(481-483)del	p.Q161del	CXXC1_ENST00000589940.1_In_Frame_Del_p.Q161del|CXXC1_ENST00000412036.2_In_Frame_Del_p.Q161del	NM_001101654.1|NM_014593.3	NP_001095124.1|NP_055408.2	Q9P0U4	CXXC1_HUMAN	CXXC finger protein 1	161					histone H3-K4 methylation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck|Set1C/COMPASS complex	protein binding|unmethylated CpG binding|zinc ion binding			autonomic_ganglia(1)|endometrium(5)|kidney(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	24						ACCGTTTGATctgctgctgctgc	0.557													15	225	---	---	---	---					
MLLT1	4298	broad.mit.edu	37	19	6222272	6222274	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:6222272_6222274delAGG	ENST00000252674.7	-	6	1131_1133	c.968_970delCCT	c.(967-972)ttc>t	p.SF323del		NM_005934.3	NP_005925.2	Q03111	ENL_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1	323	Poly-Ser.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|protein binding			endometrium(3)|kidney(3)|large_intestine(2)|lung(5)|prostate(2)|skin(2)	17						TTGTCCGAGAAGGAGGAGGAGGA	0.650			T	MLL	AL								7	217	---	---	---	---					
MUC16	94025	broad.mit.edu	37	19	9059157	9059157	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:9059157delT	ENST00000397910.4	-	3	28492	c.28289delA	c.(28288-28290)acfs	p.N9430fs		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	9432	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						TGGAGGGCTGTTTTTTTCCAC	0.512													7	756	---	---	---	---					
ECSIT	51295	broad.mit.edu	37	19	11618821	11618821	+	Frame_Shift_Del	DEL	G	G	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:11618821delG	ENST00000270517.7	-	5	916	c.781delC	c.(781-783)agfs	p.Q261fs	ECSIT_ENST00000592312.1_Frame_Shift_Del_p.Q145fs|ECSIT_ENST00000588998.1_Frame_Shift_Del_p.Q47fs|ECSIT_ENST00000417981.2_Frame_Shift_Del_p.Q47fs|ECSIT_ENST00000591352.1_5'UTR|ECSIT_ENST00000591104.1_Frame_Shift_Del_p.Q261fs|ECSIT_ENST00000252440.7_Frame_Shift_Del_p.Q261fs	NM_016581.4	NP_057665.2	Q9BQ95	ECSIT_HUMAN	ECSIT signalling integrator	261					innate immune response|regulation of oxidoreductase activity	mitochondrion	oxidoreductase activity, acting on NADH or NADPH|protein binding			kidney(2)|large_intestine(3)|lung(1)|ovary(1)|prostate(2)|skin(1)|urinary_tract(1)	11						ATGTGGGGCTGGGGGGGATCT	0.582													7	703	---	---	---	---					
ZNF563	147837	broad.mit.edu	37	19	12430217	12430217	+	Frame_Shift_Del	DEL	A	A	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:12430217delA	ENST00000293725.5	-	4	827	c.622delT	c.(622-624)ggfs	p.W208fs	ZNF563_ENST00000595977.1_Intron	NM_145276.2	NP_660319.1	Q8TA94	ZN563_HUMAN	zinc finger protein 563	208					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	20						AAACTGGGCCAAAAAAAAGCT	0.393													12	806	---	---	---	---					
KIAA1683	80726	broad.mit.edu	37	19	18376953	18376953	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:18376953delT	ENST00000392413.3	-	3	1612	c.1397delA	c.(1396-1398)acfs	p.N466fs	KIAA1683_ENST00000600359.2_Frame_Shift_Del_p.N420fs|KIAA1683_ENST00000600328.2_Frame_Shift_Del_p.N466fs	NM_001145304.1|NM_001145305.1|NM_025249.3	NP_001138776.1|NP_001138777.1|NP_079525.1	Q9H0B3	K1683_HUMAN	KIAA1683	466						mitochondrion		p.N466S(1)		breast(1)|endometrium(7)|kidney(2)|large_intestine(7)|lung(11)|ovary(2)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)	37						TTGCAATGGGTTTTTGGCTGG	0.612													7	681	---	---	---	---					
SUGP2	10147	broad.mit.edu	37	19	19136394	19136394	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:19136394delT	ENST00000601879.1	-	3	1060	c.763delA	c.(763-765)tafs	p.I255fs	SUGP2_ENST00000600377.1_Frame_Shift_Del_p.I269fs|SUGP2_ENST00000598202.1_5'UTR|SUGP2_ENST00000456085.2_Intron|SUGP2_ENST00000337018.6_Frame_Shift_Del_p.I255fs|SUGP2_ENST00000452918.2_Frame_Shift_Del_p.I255fs			Q8IX01	SUGP2_HUMAN	SURP and G patch domain containing 2	255					mRNA processing|RNA splicing	nucleus	RNA binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	43						ACGGTGGGTATTTTTTTTGTG	0.502													15	760	---	---	---	---					
CTC-559E9.6	0	broad.mit.edu	37	19	19944580	19944580	+	RNA	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:19944580delT	ENST00000591884.1	+	0	520																											ATGTTTAATCttttttttttt	0.378													7	20	---	---	---	---					
HAMP	57817	broad.mit.edu	37	19	35773520	35773522	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:35773520_35773522delCTC	ENST00000598398.1	+	2	336_338	c.40_42delCTC	c.(40-42)del	p.L18del	HAMP_ENST00000222304.3_In_Frame_Del_p.L18del	NM_021175.2	NP_066998.1	P81172	HEPC_HUMAN	hepcidin antimicrobial peptide	18					defense response to bacterium|defense response to fungus|immune response|killing of cells of other organism	extracellular region	hormone activity			breast(1)|central_nervous_system(1)|large_intestine(1)|lung(1)	4	all_lung(56;2.37e-08)|Lung NSC(56;3.66e-08)|Esophageal squamous(110;0.162)		Epithelial(14;7.4e-20)|OV - Ovarian serous cystadenocarcinoma(14;6.47e-19)|all cancers(14;4.17e-17)|LUSC - Lung squamous cell carcinoma(66;0.0417)			TTGCCTCCTGCTCCTCCTCCTCC	0.640													20	942	---	---	---	---					
ERF	2077	broad.mit.edu	37	19	42753149	42753151	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:42753149_42753151delGAA	ENST00000222329.4	-	4	1270_1272	c.1113_1115delTTC	c.(1111-1116)tcc>tc	p.SS371del	ERF_ENST00000440177.2_In_Frame_Del_p.SS296del|AC006486.9_ENST00000594664.1_Intron	NM_006494.2	NP_006485.2	P50548	ERF_HUMAN	Ets2 repressor factor	371	Poly-Ser.				cell proliferation|regulation of transcription from RNA polymerase II promoter	nucleus	ligand-regulated transcription factor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			central_nervous_system(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(7)|skin(1)	17		Prostate(69;0.00682)				GAATGGGGAGGAAGAAGAAGAAG	0.680													7	458	---	---	---	---					
DMWD	1762	broad.mit.edu	37	19	46289542	46289544	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:46289542_46289544delCTC	ENST00000270223.6	-	3	1255_1257	c.1210_1212delGAG	c.(1210-1212)del	p.E404del	DMWD_ENST00000377735.3_In_Frame_Del_p.E404del	NM_004943.1	NP_004934.1	Q09019	DMWD_HUMAN	dystrophia myotonica, WD repeat containing	404					meiosis					central_nervous_system(1)|endometrium(2)|large_intestine(5)|lung(6)|prostate(1)|upper_aerodigestive_tract(1)	16		Ovarian(192;0.0308)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00604)|GBM - Glioblastoma multiforme(486;0.0807)|Epithelial(262;0.236)		CAGCCTCGGGCTCCTCCTCCTCC	0.695													9	338	---	---	---	---					
RSPH6A	81492	broad.mit.edu	37	19	46299165	46299167	+	In_Frame_Del	DEL	CCT	CCT	-	rs62639328	byFrequency	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:46299165_46299167delCCT	ENST00000221538.3	-	6	2256_2258	c.2114_2116delAGG	c.(2113-2118)ggc>g	p.EG705del	RSPH6A_ENST00000597055.1_3'UTR|RSPH6A_ENST00000600188.1_In_Frame_Del_p.EG441del	NM_030785.3	NP_110412.1	Q9H0K4	RSH6A_HUMAN	radial spoke head 6 homolog A (Chlamydomonas)	705	Glu-rich.					intracellular				central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|prostate(1)|skin(1)|urinary_tract(2)	32						tcctcctcgccctcctcctcctc	0.586													37	759	---	---	---	---					
FUZ	80199	broad.mit.edu	37	19	50310483	50310485	+	In_Frame_Del	DEL	CAG	CAG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:50310483_50310485delCAG	ENST00000313777.4	-	11	1343_1345	c.1180_1182delCTG	c.(1180-1182)del	p.L394del	FUZ_ENST00000528094.1_In_Frame_Del_p.L358del|FUZ_ENST00000445575.2_Intron|FUZ_ENST00000533418.1_In_Frame_Del_p.L344del	NM_025129.4	NP_079405.2	Q9BT04	FUZZY_HUMAN	fuzzy planar cell polarity protein	394	Leu-rich.				cilium assembly|embryonic body morphogenesis|embryonic skeletal system morphogenesis|establishment of planar polarity|hair follicle development|neural tube closure|protein transport|regulation of smoothened signaling pathway	cytoplasm|cytoskeleton				endometrium(1)|lung(3)	4		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00793)|GBM - Glioblastoma multiforme(134;0.0116)		TCTGGGGAGACAGCAGCAGCAGC	0.635													7	303	---	---	---	---					
NUP62	23636	broad.mit.edu	37	19	50411672	50411673	+	Frame_Shift_Ins	INS	-	-	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:50411672_50411673insG	ENST00000596217.1	-	2	3279_3280	c.1392_1393insC	c.(1390-1395)ccccgafs	p.R465fs	NUP62_ENST00000413454.1_Frame_Shift_Ins_p.R465fs|IL4I1_ENST00000595948.1_Intron|NUP62_ENST00000422090.2_Frame_Shift_Ins_p.R465fs|NUP62_ENST00000352066.3_Frame_Shift_Ins_p.R465fs|NUP62_ENST00000597029.1_Frame_Shift_Ins_p.R465fs|IL4I1_ENST00000341114.3_Intron|NUP62_ENST00000597723.1_Frame_Shift_Ins_p.R389fs			P37198	NUP62_HUMAN	nucleoporin 62kDa	465					carbohydrate metabolic process|cell death|cell surface receptor linked signaling pathway|glucose transport|hormone-mediated signaling pathway|mRNA transport|negative regulation of apoptosis|negative regulation of cell proliferation|nucleocytoplasmic transport|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription, DNA-dependent|protein transport|regulation of glucose transport|transcription, DNA-dependent|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleocytoplasmic shuttling complex|ribonucleoprotein complex|spindle pole	chromatin binding|protein serine/threonine kinase activity|receptor signaling complex scaffold activity|SH2 domain binding|structural constituent of nuclear pore|thyroid hormone receptor binding|ubiquitin binding			breast(2)|endometrium(1)|kidney(1)|large_intestine(4)|lung(8)|stomach(1)|urinary_tract(2)	19		all_lung(116;1.47e-05)|all_neural(266;0.0459)|Ovarian(192;0.0481)		GBM - Glioblastoma multiforme(134;0.00242)|OV - Ovarian serous cystadenocarcinoma(262;0.0177)		CTGGTGTCGGCGGGGGCCCCGG	0.579													7	1141	---	---	---	---					
LILRB5	0	broad.mit.edu	37	19	54754872	54754873	+	Frame_Shift_Ins	INS	-	-	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:54754872_54754873insA	ENST00000450632.1	-	13	1839_1840	c.1762_1763insT	c.(1762-1764)agtfs	p.S588fs	LILRB5_ENST00000345866.6_Intron|LILRB5_ENST00000316219.5_Intron|LILRB5_ENST00000449561.2_Intron			O75023	LIRB5_HUMAN	leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5	394					cell surface receptor linked signaling pathway|defense response	integral to membrane	transmembrane receptor activity			NS(1)|breast(1)|endometrium(3)|kidney(5)|large_intestine(12)|lung(25)|ovary(1)|pancreas(1)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	56	all_cancers(19;0.00681)|all_epithelial(19;0.00368)|all_lung(19;0.016)|Lung NSC(19;0.0296)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		GGAAAGGACTCTCTCAGTGTCC	0.609													9	159	---	---	---	---					
NLRP2	55655	broad.mit.edu	37	19	55494630	55494632	+	In_Frame_Del	DEL	GAA	GAA	-	rs3745905	byFrequency	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:55494630_55494632delGAA	ENST00000543010.1	+	6	1707_1709	c.1564_1566delGAA	c.(1564-1566)del	p.E523del	NLRP2_ENST00000427260.2_In_Frame_Del_p.E500del|NLRP2_ENST00000538819.1_In_Frame_Del_p.E499del|NLRP2_ENST00000537859.1_In_Frame_Del_p.E501del|NLRP2_ENST00000263437.6_In_Frame_Del_p.E520del|NLRP2_ENST00000448584.2_In_Frame_Del_p.E523del|NLRP2_ENST00000391721.4_In_Frame_Del_p.E499del|NLRP2_ENST00000339757.7_In_Frame_Del_p.E501del	NM_001174081.1	NP_001167552.1	Q9NX02	NALP2_HUMAN	NLR family, pyrin domain containing 2	523	NACHT.|Poly-Glu.				apoptosis|positive regulation of caspase activity|positive regulation of interleukin-1 beta secretion	cytoplasm	ATP binding|Pyrin domain binding			large_intestine(4)|liver(1)|ovary(1)|skin(2)|upper_aerodigestive_tract(3)	11			BRCA - Breast invasive adenocarcinoma(297;0.163)	GBM - Glioblastoma multiforme(193;0.028)		GAAGGAGGAGGAAGAGGATAGGG	0.567													8	468	---	---	---	---					
ZNF548	147694	broad.mit.edu	37	19	57908592	57908592	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:57908592delT	ENST00000598895.1	+	3	444	c.228delT	c.(226-228)ccfs	p.P76fs	AC003002.4_ENST00000597658.1_Intron|ZNF548_ENST00000597400.1_Intron|ZNF548_ENST00000336128.7_Intron|AC003002.6_ENST00000600421.1_Intron|AC004076.7_ENST00000597410.1_Intron|AC003002.6_ENST00000596400.1_Intron|ZNF548_ENST00000366197.5_Intron			Q8NEK5	ZN548_HUMAN	zinc finger protein 548	0	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GTGTTACCCCTTTTTACCCAA	0.542													7	1298	---	---	---	---					
ZNF329	79673	broad.mit.edu	37	19	58639340	58639341	+	Frame_Shift_Ins	INS	-	-	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr19:58639340_58639341insG	ENST00000598312.1	-	4	1763_1764	c.1530_1531insC	c.(1528-1533)ccgccgfs	p.P511fs	ZNF329_ENST00000358067.4_Frame_Shift_Ins_p.P511fs	NM_024620.3	NP_078896.3	Q86UD4	ZN329_HUMAN	zinc finger protein 329	511					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|large_intestine(10)|lung(5)|skin(3)|urinary_tract(1)	20		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.029)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)|Lung(386;0.216)		GGACACCGGCTGGGACCCTCCC	0.500													8	1108	---	---	---	---					
RP4-697P8.3	0	broad.mit.edu	37	20	10869748	10869748	+	RNA	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr20:10869748delT	ENST00000448859.1	-	0	1058				RP11-103J8.1_ENST00000605292.1_RNA																							TCtttttttattttttttttt	0.438													8	126	---	---	---	---					
SYNDIG1	79953	broad.mit.edu	37	20	24524183	24524185	+	In_Frame_Del	DEL	GGA	GGA	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr20:24524183_24524185delGGA	ENST00000376862.3	+	2	1083_1085	c.450_452delGGA	c.(448-453)gtg>gt	p.VE150del		NM_024893.1	NP_079169.1	Q9H7V2	SYNG1_HUMAN	synapse differentiation inducing 1	150					response to biotic stimulus	early endosome membrane|integral to membrane|plasma membrane				breast(2)|endometrium(1)|large_intestine(3)|lung(14)|prostate(1)|skin(3)	24						CCTACGATGTGGAGGAGGAGGAG	0.547													12	955	---	---	---	---					
FRG1B	0	broad.mit.edu	37	20	29624034	29624035	+	Frame_Shift_Ins	INS	-	-	G	rs73621649		TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr20:29624034_29624035insG	ENST00000439954.2	+	4	419_420	c.73_74insG	c.(73-75)tgafs	p.*25fs	FRG1B_ENST00000358464.4_Intron|FRG1B_ENST00000278882.3_Intron																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TTTCTCCAATATTGATGAGGGC	0.287													9	130	---	---	---	---					
PIGP	51227	broad.mit.edu	37	21	38444815	38444815	+	Translation_Start_Site	DEL	T	T	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr21:38444815delT	ENST00000399098.1	-	0	193				PIGP_ENST00000464265.1_Frame_Shift_Del_p.M25fs|PIGP_ENST00000399102.1_Start_Codon_Del|PIGP_ENST00000399103.1_Start_Codon_Del|PIGP_ENST00000360525.3_Start_Codon_Del|PIGP_ENST00000329667.3_5'UTR			P57054	PIGP_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class P						C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			kidney(1)|urinary_tract(1)	2		Myeloproliferative disorder(46;0.0412)				TTTTCCACCATTTTTCCTGGG	0.488													8	1114	---	---	---	---					
PWP2	5822	broad.mit.edu	37	21	45535692	45535694	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr21:45535692_45535694delGAG	ENST00000291576.7	+	7	854_856	c.727_729delGAG	c.(727-729)del	p.E247del		NM_005049.2	NP_005040.2	Q15269	PWP2_HUMAN	PWP2 periodic tryptophan protein homolog (yeast)	247	Poly-Glu.					cytoplasm|nucleolus	signal transducer activity			cervix(1)|endometrium(6)|large_intestine(6)|lung(4)|pancreas(1)|prostate(1)|stomach(1)|urinary_tract(1)	21				STAD - Stomach adenocarcinoma(101;0.172)|Colorectal(79;0.2)		ggaggaggaagaggaggaggagg	0.640													8	200	---	---	---	---					
PTTG1IP	754	broad.mit.edu	37	21	46276194	46276196	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr21:46276194_46276196delGCA	ENST00000330938.3	-	4	581_583	c.361_363delTGC	c.(361-363)del	p.C121del	PTTG1IP_ENST00000397886.3_In_Frame_Del_p.C100del|PTTG1IP_ENST00000397887.3_Intron|PTTG1IP_ENST00000494690.1_5'UTR|PTTG1IP_ENST00000445724.2_Intron	NM_004339.3	NP_004330.1	P53801	PTTG_HUMAN	pituitary tumor-transforming 1 interacting protein	121	Poly-Cys.				protein import into nucleus	cytoplasm|integral to membrane|nucleus				ovary(1)|prostate(1)	2				Colorectal(79;0.0659)		TCTTCCTCCTGCAGCAGCAGCAG	0.616													8	352	---	---	---	---					
CCT8L2	150160	broad.mit.edu	37	22	17071786	17071787	+	Frame_Shift_Ins	INS	-	-	T			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr22:17071786_17071787insT	ENST00000359963.3	-	1	1913_1914	c.1654_1655insA	c.(1654-1656)cctfs	p.P552fs		NM_014406.4	NP_055221.1	Q96SF2	TCPQM_HUMAN	chaperonin containing TCP1, subunit 8 (theta)-like 2	552					cellular protein metabolic process	cytoplasm	anion channel activity|ATP binding|calcium-activated potassium channel activity			breast(3)|endometrium(7)|kidney(1)|large_intestine(8)|liver(2)|lung(37)|ovary(3)|prostate(3)|skin(2)|stomach(1)	67	all_hematologic(4;0.00567)|Acute lymphoblastic leukemia(84;0.0977)	all_epithelial(15;0.0157)|Lung NSC(13;0.147)|all_lung(157;0.175)				CAATCCAAGGATTTTTTTTGTT	0.411													7	577	---	---	---	---					
MYH9	4627	broad.mit.edu	37	22	36689419	36689421	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr22:36689419_36689421delCCT	ENST00000216181.5	-	30	4279_4281	c.4049_4051delAGG	c.(4048-4053)gcc>g	p.EA1350del		NM_002473.4	NP_002464.1	P35579	MYH9_HUMAN	myosin, heavy chain 9, non-muscle	1350				E -> EE (in Ref. 7).	actin cytoskeleton reorganization|actin filament-based movement|angiogenesis|axon guidance|blood vessel endothelial cell migration|cytokinesis|integrin-mediated signaling pathway|leukocyte migration|membrane protein ectodomain proteolysis|monocyte differentiation|platelet formation|protein transport|regulation of cell shape	actomyosin contractile ring|cleavage furrow|cytosol|myosin complex|nucleus|ruffle|stress fiber|uropod	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity|protein anchor|protein homodimerization activity			NS(1)|breast(8)|central_nervous_system(3)|cervix(2)|endometrium(5)|kidney(4)|large_intestine(16)|lung(29)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(6)|urinary_tract(3)	86						TTGTGCTTGGCCTCCTCCTCCTC	0.650			T	ALK	ALCL		"""Deafness, autosomal dominant 17, Epstein syndrome, Fechtner syndrome, May-Hegglin anomaly, Sebastian syndrome"""		Hereditary Macrothrombocytopenia, MYH9-associated				8	432	---	---	---	---					
RANGAP1	5905	broad.mit.edu	37	22	41650469	41650471	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr22:41650469_41650471delTCC	ENST00000455915.2	-	10	2570_2572	c.1101_1103delGGA	c.(1099-1104)gaa>ga	p.EE367del	RANGAP1_ENST00000407260.4_In_Frame_Del_p.EE312del|RANGAP1_ENST00000405486.1_In_Frame_Del_p.EE367del|RANGAP1_ENST00000356244.3_In_Frame_Del_p.EE367del			P46060	RAGP1_HUMAN	Ran GTPase activating protein 1	367	Asp/Glu-rich (highly acidic).				mitotic prometaphase|signal transduction	condensed chromosome kinetochore|cytosol|nuclear membrane|nuclear pore|soluble fraction|spindle pole	protein binding|Ran GTPase activator activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(2)|large_intestine(3)|lung(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	19						ctcttctccttcctcctcctcct	0.562													22	546	---	---	---	---					
MLC1	23209	broad.mit.edu	37	22	50506871	50506872	+	Frame_Shift_Ins	INS	-	-	G			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chr22:50506871_50506872insG	ENST00000311597.5	-	10	1490_1491	c.884_885insC	c.(883-885)cgcfs	p.R295fs	MLC1_ENST00000431262.2_Frame_Shift_Ins_p.R265fs|MLC1_ENST00000395876.2_Frame_Shift_Ins_p.R295fs|MLC1_ENST00000535444.1_Frame_Shift_Ins_p.R216fs|MLC1_ENST00000483836.1_5'UTR|MLC1_ENST00000538737.1_Frame_Shift_Ins_p.R261fs|MLC1_ENST00000450140.2_Frame_Shift_Ins_p.R243fs	NM_015166.3	NP_055981.1	Q15049	MLC1_HUMAN	megalencephalic leukoencephalopathy with subcortical cysts 1	295						basolateral plasma membrane|endosome|integral to membrane|integral to membrane of membrane fraction	ion channel activity			endometrium(1)|kidney(1)|large_intestine(5)|lung(7)|pancreas(1)|prostate(3)	18		all_cancers(38;7.69e-11)|all_epithelial(38;9.52e-10)|all_lung(38;3.67e-05)|Breast(42;0.000776)|Lung NSC(38;0.000946)|Ovarian(80;0.0365)|Lung SC(80;0.113)		READ - Rectum adenocarcinoma(2;0.000669)|Colorectal(2;0.00242)|LUAD - Lung adenocarcinoma(64;0.0695)|BRCA - Breast invasive adenocarcinoma(115;0.216)		CTTTTATGGCTGGCGGGTAATC	0.525													12	590	---	---	---	---					
RBM10	8241	broad.mit.edu	37	X	47030586	47030588	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chrX:47030586_47030588delGAG	ENST00000377604.3	+	4	1103_1105	c.361_363delGAG	c.(361-363)del	p.E125del	RBM10_ENST00000468791.1_3'UTR|RBM10_ENST00000329236.7_Intron|RBM10_ENST00000345781.6_Intron	NM_001204467.1|NM_001204468.1|NM_005676.4	NP_001191396.1|NP_001191397.1|NP_005667.2	P98175	RBM10_HUMAN	RNA binding motif protein 10	125	Poly-Glu.				mRNA processing|RNA splicing	chromatin remodeling complex	nucleotide binding|RNA binding|zinc ion binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(8)|large_intestine(10)|liver(1)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	48						ggaggaggatgaggaggaggagg	0.665													7	52	---	---	---	---					
NAP1L3	4675	broad.mit.edu	37	X	92928153	92928155	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chrX:92928153_92928155delTGC	ENST00000373079.3	-	1	412_414	c.149_151delGCA	c.(148-153)act>a	p.ST50del	NAP1L3_ENST00000475430.1_5'UTR	NM_004538.5	NP_004529.2	Q99457	NP1L3_HUMAN	nucleosome assembly protein 1-like 3	50	Ser-rich.				nucleosome assembly	chromatin assembly complex				haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(16)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	34						ctgccactagtgctgctgctgct	0.586													8	80	---	---	---	---					
MAGEC1	9947	broad.mit.edu	37	X	140994114	140994116	+	In_Frame_Del	DEL	CTC	CTC	-	rs141900922	byFrequency	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chrX:140994114_140994116delCTC	ENST00000285879.4	+	4	1210_1212	c.924_926delCTC	c.(922-927)agc>ag	p.SS312del	MAGEC1_ENST00000406005.2_Intron	NM_005462.4	NP_005453.2	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	312							protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(22)|lung(60)|ovary(1)|pancreas(1)|prostate(1)|skin(7)|stomach(5)|upper_aerodigestive_tract(7)|urinary_tract(1)	127	Acute lymphoblastic leukemia(192;6.56e-05)					TTCCTGTGAGCTCCTCCTCCTCC	0.483										HNSCC(15;0.026)			8	1763	---	---	---	---					
CD99L2	83692	broad.mit.edu	37	X	149937526	149937528	+	In_Frame_Del	DEL	GGC	GGC	-	rs7877654	byFrequency	TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chrX:149937526_149937528delGGC	ENST00000370377.3	-	11	885_887	c.768_770delGCC	c.(766-771)ccc>cc	p.PP256del	CD99L2_ENST00000437787.2_In_Frame_Del_p.PP183del|CD99L2_ENST00000355149.3_In_Frame_Del_p.PP184del|CD99L2_ENST00000346693.4_5'UTR|CD99L2_ENST00000466436.1_In_Frame_Del_p.PP207del	NM_001242614.1|NM_031462.3	NP_001229543.1|NP_113650.2	Q8TCZ2	C99L2_HUMAN	CD99 molecule-like 2	256	Poly-Pro.				cell adhesion	cell junction|integral to membrane				endometrium(4)|large_intestine(4)|lung(10)|ovary(3)|skin(1)|urinary_tract(1)	23	Acute lymphoblastic leukemia(192;6.56e-05)					GGCTGGTTCGGGCGGCGGCGGCG	0.611													7	503	---	---	---	---					
PASD1	139135	broad.mit.edu	37	X	150817142	150817144	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chrX:150817142_150817144delGCT	ENST00000370357.4	+	9	930_932	c.685_687delGCT	c.(685-687)del	p.A236del		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	236	Poly-Ala.					nucleus	signal transducer activity	p.A229A(2)		breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					CGTTGAACCCgctgctgctgctg	0.433													9	395	---	---	---	---					
UTY	7404	broad.mit.edu	37	Y	15448217	15448218	+	Splice_Site	INS	-	-	A			TCGA-HZ-7920-01A-11D-2201-08	TCGA-HZ-7920-10B-01D-2201-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	c9b48534-d832-41b4-b67a-d8f4b44d24f1	f34639f3-59c0-430e-9ae0-1eef76fe86aa	g.chrY:15448217_15448218insA	ENST00000331397.4	-	16	2778		c.e16-2		UTY_ENST00000545955.1_Splice_Site|UTY_ENST00000538878.1_Splice_Site|UTY_ENST00000329134.5_Splice_Site|UTY_ENST00000537580.1_Splice_Site|UTY_ENST00000382896.4_Splice_Site|UTY_ENST00000540140.1_Splice_Site|UTY_ENST00000362096.4_Splice_Site	NM_001258267.1|NM_007125.4	NP_001245196.1|NP_009056.3	O14607	UTY_HUMAN	ubiquitously transcribed tetratricopeptide repeat containing, Y-linked						chromatin modification	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(1)|lung(6)	7						ATGAAGCCCCTAAAAAAAAAAA	0.361													19	95	---	---	---	---					
