Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
SLC9A6	10479	broad.mit.edu	37	X	135106617	135106617	+	Missense_Mutation	SNP	G	G	C			TCGA-EM-A3FR-01A-11D-A21Z-08	TCGA-EM-A3FR-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bae2f08-da75-4991-acb8-5ba9912f9131	d2f5c569-964a-4cb4-a77e-a3df7bfbe36a	g.chrX:135106617G>C	uc004ezk.3	+	11	1667	c.1591G>C	c.(1591-1593)Gca>Cca	p.A531P	SLC9A6_uc011mvx.2_Missense_Mutation_p.A479P|SLC9A6_uc004ezj.3_Missense_Mutation_p.A499P	NM_001042537	NP_001036002	Q92581	SL9A6_HUMAN	Homo sapiens solute carrier family 9 (sodium/hydrogen exchanger), member 6 (SLC9A6), transcript variant 1, mRNA.	499					regulation of pH	early endosome membrane|endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane|recycling endosome membrane	sodium:hydrogen antiporter activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(18)|ovary(2)|upper_aerodigestive_tract(1)	33	Acute lymphoblastic leukemia(192;0.000127)					TGGCACCACTGCAATGCTGTC	0.393000													58	151					0	0	1	0	0
EIF2AK4	440275	broad.mit.edu	37	15	40268678	40268678	+	Silent	SNP	C	C	A			TCGA-EM-A3FR-01A-11D-A21Z-08	TCGA-EM-A3FR-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bae2f08-da75-4991-acb8-5ba9912f9131	d2f5c569-964a-4cb4-a77e-a3df7bfbe36a	g.chr15:40268678C>A	uc001zkm.1	+	11	1932	c.1882C>A	c.(1882-1884)Cgg>Agg	p.R628R	EIF2AK4_uc010bbj.1_Silent_p.R357R	NM_001013703	NP_001013725	Q9P2K8	E2AK4_HUMAN	Homo sapiens eukaryotic translation initiation factor 2 alpha kinase 4 (EIF2AK4), mRNA.	628	Protein kinase 2.				translation	cytosolic ribosome	ATP binding|aminoacyl-tRNA ligase activity|eukaryotic translation initiation factor 2alpha kinase activity|protein homodimerization activity			NS(1)|breast(2)|endometrium(1)|kidney(3)|large_intestine(8)|lung(18)|ovary(1)|prostate(3)|skin(2)|stomach(1)	40		all_cancers(109;1.05e-19)|all_epithelial(112;4.38e-17)|Lung NSC(122;1.09e-12)|all_lung(180;3.56e-11)|Melanoma(134;0.0575)|Ovarian(310;0.0826)|Colorectal(260;0.119)		GBM - Glioblastoma multiforme(113;5.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0616)		CCCGGCCAGCCGGCAGTTCCG	0.632000													3	79					0	0	1	0	0
GAD2	2572	broad.mit.edu	37	10	26508106	26508106	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A3FR-01A-11D-A21Z-08	TCGA-EM-A3FR-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bae2f08-da75-4991-acb8-5ba9912f9131	d2f5c569-964a-4cb4-a77e-a3df7bfbe36a	g.chr10:26508106C>T	uc001isp.2	+	3	924	c.421C>T	c.(421-423)Ctt>Ttt	p.L141F	GAD2_uc009xkr.3_Missense_Mutation_p.L141F|GAD2_uc001isq.2_Missense_Mutation_p.L141F	NM_001134366	NP_001127838	Q05329	DCE2_HUMAN	Homo sapiens glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) (GAD2), transcript variant 2, mRNA.	141					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	Golgi membrane|cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|endometrium(2)|large_intestine(8)|lung(26)|ovary(1)|pancreas(1)|prostate(3)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	48					L-Glutamic Acid(DB00142)	TCCTAATGAGCTTCTCCAAGA	0.343000													20	174					0	0	1	0	0
INPP5D	3635	broad.mit.edu	37	2	233990613	233990613	+	Missense_Mutation	SNP	A	A	T			TCGA-EM-A3FR-01A-11D-A21Z-08	TCGA-EM-A3FR-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bae2f08-da75-4991-acb8-5ba9912f9131	d2f5c569-964a-4cb4-a77e-a3df7bfbe36a	g.chr2:233990613A>T	uc010zmo.2	+	3	661	c.508A>T	c.(508-510)Agc>Tgc	p.S170C	INPP5D_uc010zmp.2_Missense_Mutation_p.S169C	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	Homo sapiens inositol polyphosphate-5-phosphatase, 145kDa (INPP5D), transcript variant 1, mRNA.	170					T cell receptor signaling pathway|apoptosis|blood coagulation|leukocyte migration	cytosol	SH3 domain binding|inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity			central_nervous_system(1)|ovary(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		GCGACTGCAAAGCATGGACAC	0.602000													7	32					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9074980	9074980	+	Missense_Mutation	SNP	T	T	C			TCGA-EM-A3FR-01A-11D-A21Z-08	TCGA-EM-A3FR-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bae2f08-da75-4991-acb8-5ba9912f9131	d2f5c569-964a-4cb4-a77e-a3df7bfbe36a	g.chr19:9074980T>C	uc002mkp.3	-	2	12670	c.12466A>G	c.(12466-12468)Acc>Gcc	p.T4156A		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	Homo sapiens mucin 16, cell surface associated (MUC16), mRNA.	4158	Ser-rich.|Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.T4156T(1)		NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GAAGAGCTGGTTTCTTCCACA	0.493000													20	104					0	0	1	0	0
FMNL3	91010	broad.mit.edu	37	12	50050234	50050234	+	Nonsense_Mutation	SNP	G	G	A			TCGA-EM-A3FR-01A-11D-A21Z-08	TCGA-EM-A3FR-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bae2f08-da75-4991-acb8-5ba9912f9131	d2f5c569-964a-4cb4-a77e-a3df7bfbe36a	g.chr12:50050234G>A	uc001ruv.1	-	8	1072	c.838C>T	c.(838-840)Cga>Tga	p.R280*	FMNL3_uc001ruw.1_Nonsense_Mutation_p.R229*|FMNL3_uc001ruu.1_Nonsense_Mutation_p.R130*	NM_175736	NP_783863	Q8IVF7	FMNL3_HUMAN	Homo sapiens formin-like 3 (FMNL3), transcript variant 1, mRNA.	280	GBD/FH3.				actin cytoskeleton organization		Rho GTPase binding|actin binding			breast(4)|endometrium(7)|kidney(2)|large_intestine(6)|lung(11)|ovary(2)|pancreas(2)|prostate(2)|skin(2)|stomach(1)	39						TGACCTCCTCGCACCAAACAC	0.507000													3	52					0	0	1	0	0
FMNL1	752	broad.mit.edu	37	17	43311541	43311541	+	Silent	SNP	G	G	A			TCGA-EM-A3FR-01A-11D-A21Z-08	TCGA-EM-A3FR-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bae2f08-da75-4991-acb8-5ba9912f9131	d2f5c569-964a-4cb4-a77e-a3df7bfbe36a	g.chr17:43311541G>A	uc002iin.3	+	5	788	c.588G>A	c.(586-588)gtG>gtA	p.V196V	FMNL1_uc002iio.3_Silent_p.V141V	NM_005892	NP_005883	O95466	FMNL_HUMAN	Homo sapiens formin-like 1 (FMNL1), mRNA.	196	GBD/FH3.				actin cytoskeleton organization		Rho GTPase binding|actin binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(4)|kidney(2)|large_intestine(8)|lung(12)|pancreas(1)|skin(1)|urinary_tract(2)	33						CCTCCTCCGTGCCCAAAAGCC	0.572000													44	66					0	0	1	0	0
FASN	2194	broad.mit.edu	37	17	80043235	80043235	+	Missense_Mutation	SNP	A	A	T			TCGA-EM-A3FR-01A-11D-A21Z-08	TCGA-EM-A3FR-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bae2f08-da75-4991-acb8-5ba9912f9131	d2f5c569-964a-4cb4-a77e-a3df7bfbe36a	g.chr17:80043235A>T	uc002kdu.3	-	23	4283	c.4166T>A	c.(4165-4167)gTg>gAg	p.V1389E	FASN_uc002kdw.1_Missense_Mutation_p.V605E	NM_004104	NP_004095	P49327	FAS_HUMAN	Homo sapiens fatty acid synthase (FASN), mRNA.	1389					energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	Golgi apparatus|cytosol|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)|skin(2)|urinary_tract(1)	34	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	CTTCAGGCCCACCAGGCGCAG	0.701000													6	15					0	0	1	0	0
GARNL3	84253	broad.mit.edu	37	9	130106562	130106562	+	Missense_Mutation	SNP	A	A	G			TCGA-EM-A3FR-01A-11D-A21Z-08	TCGA-EM-A3FR-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bae2f08-da75-4991-acb8-5ba9912f9131	d2f5c569-964a-4cb4-a77e-a3df7bfbe36a	g.chr9:130106562A>G	uc011mae.2	+	14	1701	c.1300A>G	c.(1300-1302)Aag>Gag	p.K434E	GARNL3_uc011mad.2_Missense_Mutation_p.K412E|GARNL3_uc004bqt.1_Missense_Mutation_p.K215E	NM_032293	NP_115669	Q5VVW2	GARL3_HUMAN	Homo sapiens GTPase activating Rap/RanGAP domain-like 3 (GARNL3), mRNA.	434					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity|small GTPase regulator activity	p.Q434K(1)		NS(1)|central_nervous_system(1)|endometrium(6)|large_intestine(5)|lung(24)|ovary(1)|skin(1)|urinary_tract(2)	41						AGAGTCACCCAAGTCAGCGCG	0.423000													17	280					0	0	1	0	0
SNAI2	6591	broad.mit.edu	37	8	49832563	49832563	+	Missense_Mutation	SNP	C	C	T			TCGA-EM-A3FR-01A-11D-A21Z-08	TCGA-EM-A3FR-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bae2f08-da75-4991-acb8-5ba9912f9131	d2f5c569-964a-4cb4-a77e-a3df7bfbe36a	g.chr8:49832563C>T	uc003xqp.3	-	1	692	c.517G>A	c.(517-519)Gcc>Acc	p.A173T		NM_003068	NP_003059	O43623	SNAI2_HUMAN	Homo sapiens snail homolog 2 (Drosophila) (SNAI2), mRNA.	173					canonical Wnt receptor signaling pathway|ectoderm and mesoderm interaction|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|osteoblast differentiation|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(9)|ovary(2)|prostate(1)	18		all_cancers(86;0.0368)|all_epithelial(80;0.000624)|Lung NSC(129;0.0019)|all_lung(136;0.00502)				ATCTTCAGGGCGCCCAGGCTC	0.483000													34	52					0	0	1	0	0
ZNF300	91975	broad.mit.edu	37	5	150278070	150278070	+	Missense_Mutation	SNP	T	T	C			TCGA-EM-A3FR-01A-11D-A21Z-08	TCGA-EM-A3FR-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bae2f08-da75-4991-acb8-5ba9912f9131	d2f5c569-964a-4cb4-a77e-a3df7bfbe36a	g.chr5:150278070T>C	uc021yfx.1	-	4	538	c.110A>G	c.(109-111)gAg>gGg	p.E37G	ZNF300_uc021yfy.1_Missense_Mutation_p.E21G|ZNF300_uc021yfz.1_5'UTR	NM_001172831	NP_001166303	Q96RE9	ZN300_HUMAN	Homo sapiens zinc finger protein 300 (ZNF300), transcript variant 1, mRNA.	21	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(3)|large_intestine(3)|lung(13)|ovary(1)|prostate(1)|skin(2)	27		Medulloblastoma(196;0.109)|all_hematologic(541;0.131)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TTGCTGCCACTCCTCCTGGGT	0.463000													42	224					0	0	1	0	0
ITIH6	347365	broad.mit.edu	37	X	54776381	54776381	+	Missense_Mutation	SNP	G	G	A	rs149644769	byFrequency	TCGA-EM-A3FR-01A-11D-A21Z-08	TCGA-EM-A3FR-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bae2f08-da75-4991-acb8-5ba9912f9131	d2f5c569-964a-4cb4-a77e-a3df7bfbe36a	g.chrX:54776381G>A	uc004dtj.2	-	12	3919	c.3889C>T	c.(3889-3891)Cgc>Tgc	p.R1297C		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	Homo sapiens inter-alpha-trypsin inhibitor heavy chain family, member 6 (ITIH6), mRNA.	1297					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity										ACATGAGAGCGCTTCACCAGC	0.577000													4	57					0	0	1	0	0
CFTR	1080	broad.mit.edu	37	7	117234990	117234990	+	Missense_Mutation	SNP	T	T	C			TCGA-EM-A3FR-01A-11D-A21Z-08	TCGA-EM-A3FR-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bae2f08-da75-4991-acb8-5ba9912f9131	d2f5c569-964a-4cb4-a77e-a3df7bfbe36a	g.chr7:117234990T>C	uc003vjd.3	+	14	2629	c.2497T>C	c.(2497-2499)Ttt>Ctt	p.F833L	CFTR_uc011knq.2_Missense_Mutation_p.F239L	NM_000492	NP_000483	P13569	CFTR_HUMAN	Homo sapiens cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (CFTR), mRNA.	833				F -> L (in Ref. 1; AAA35680).	respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|PDZ domain binding|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(15)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(9)	69	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	TCAGGAGTGCTTTTTTGATGA	0.323000									Cystic Fibrosis				3	107					0	0	1	0	0
XPR1	9213	broad.mit.edu	37	1	180849246	180849246	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A3FR-01A-11D-A21Z-08	TCGA-EM-A3FR-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bae2f08-da75-4991-acb8-5ba9912f9131	d2f5c569-964a-4cb4-a77e-a3df7bfbe36a	g.chr1:180849246G>A	uc001goi.3	+	13	2035	c.1843G>A	c.(1843-1845)Gaa>Aaa	p.E615K	XPR1_uc009wxn.3_Missense_Mutation_p.E550K	NM_004736	NP_004727	Q9UBH6	XPR1_HUMAN	Homo sapiens xenotropic and polytropic retrovirus receptor 1 (XPR1), transcript variant 1, mRNA.	615	EXS.					integral to plasma membrane	G-protein coupled receptor activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(15)|lung(7)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(5)	35						CCTGGAGAATGAACATCTGAA	0.458000													45	51					0	0	1	0	0
PLXNA2	5362	broad.mit.edu	37	1	208234068	208234068	+	Missense_Mutation	SNP	A	A	G			TCGA-EM-A3FR-01A-11D-A21Z-08	TCGA-EM-A3FR-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bae2f08-da75-4991-acb8-5ba9912f9131	d2f5c569-964a-4cb4-a77e-a3df7bfbe36a	g.chr1:208234068A>G	uc001hgz.3	-	12	3459	c.2701T>C	c.(2701-2703)Tgc>Cgc	p.C901R		NM_025179	NP_079455	O75051	PLXA2_HUMAN	Homo sapiens plexin A2 (PLXNA2), mRNA.	901	IPT/TIG 1.				axon guidance	integral to membrane|intracellular|plasma membrane				NS(1)|breast(3)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|liver(1)|lung(28)|ovary(3)|prostate(5)|skin(2)|upper_aerodigestive_tract(3)	80				OV - Ovarian serous cystadenocarcinoma(81;0.199)		AGGGGCGTGCAGGGCACCCCA	0.637000													3	52					0	0	1	0	0
PNLDC1	154197	broad.mit.edu	37	6	160225058	160225058	+	Missense_Mutation	SNP	G	G	C			TCGA-EM-A3FR-01A-11D-A21Z-08	TCGA-EM-A3FR-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bae2f08-da75-4991-acb8-5ba9912f9131	d2f5c569-964a-4cb4-a77e-a3df7bfbe36a	g.chr6:160225058G>C	uc003qsy.1	+	4	349	c.310G>C	c.(310-312)Gaa>Caa	p.E104Q	PNLDC1_uc003qsx.1_Missense_Mutation_p.E93Q	NM_173516	NP_775787	Q8NA58	PNDC1_HUMAN	Homo sapiens poly(A)-specific ribonuclease (PARN)-like domain containing 1 (PNLDC1), mRNA.	93						integral to membrane|nucleus	nucleic acid binding			autonomic_ganglia(1)|breast(1)|endometrium(1)|kidney(2)|large_intestine(11)|lung(9)|ovary(1)|prostate(2)|skin(1)|stomach(1)|urinary_tract(1)	31		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;1.55e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		TTTGGACTCAGAATTCTCCTT	0.398000													100	184					0	0	1	0	0
LRSAM1	90678	broad.mit.edu	37	9	130253549	130253549	+	Missense_Mutation	SNP	A	A	G			TCGA-EM-A3FR-01A-11D-A21Z-08	TCGA-EM-A3FR-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bae2f08-da75-4991-acb8-5ba9912f9131	d2f5c569-964a-4cb4-a77e-a3df7bfbe36a	g.chr9:130253549A>G	uc004brb.2	+	19	1850	c.1478A>G	c.(1477-1479)aAg>aGg	p.K493R	LRSAM1_uc010mxk.2_Intron|LRSAM1_uc004brc.2_Missense_Mutation_p.K493R|LRSAM1_uc004brd.2_Missense_Mutation_p.K493R|LRSAM1_uc004bre.2_Missense_Mutation_p.K73R	NM_001005373	NP_612370	Q6UWE0	LRSM1_HUMAN	Homo sapiens leucine rich repeat and sterile alpha motif containing 1 (LRSAM1), transcript variant 2, mRNA.	493					negative regulation of endocytosis|non-lytic virus budding|protein autoubiquitination|protein catabolic process|protein polyubiquitination|protein transport|ubiquitin-dependent endocytosis	cytoplasm|extracellular region|membrane part	hormone activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(6)|ovary(2)	16						TTAAAGAGGAAGTCCCTGGAC	0.507000													4	75					0	0	1	0	0
SPOP	8405	broad.mit.edu	37	17	47696667	47696667	+	Missense_Mutation	SNP	G	G	C			TCGA-EM-A3FR-01A-11D-A21Z-08	TCGA-EM-A3FR-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bae2f08-da75-4991-acb8-5ba9912f9131	d2f5c569-964a-4cb4-a77e-a3df7bfbe36a	g.chr17:47696667G>C	uc010dbk.3	-	4	913	c.281C>G	c.(280-282)cCa>cGa	p.P94R	SPOP_uc002ipg.3_Missense_Mutation_p.P94R|SPOP_uc002ipb.3_Missense_Mutation_p.P94R|SPOP_uc002ipc.3_Missense_Mutation_p.P94R|SPOP_uc002ipd.3_Missense_Mutation_p.P94R|SPOP_uc002ipe.3_Missense_Mutation_p.P94R|SPOP_uc002ipf.3_Missense_Mutation_p.P94R	NM_003563	NP_003554	O43791	SPOP_HUMAN	Homo sapiens speckle-type POZ protein (SPOP), transcript variant 2, mRNA.	94	MATH.|Required for nuclear localization.				mRNA processing	nucleus	protein binding			endometrium(18)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|ovary(3)|prostate(33)	63						TTCACTCTTTGGACAGCTGAC	0.413000										Prostate(2;0.17)			45	89					0	0	1	0	0
ARHGEF10L	55160	broad.mit.edu	37	1	17914071	17914071	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A3FR-01A-11D-A21Z-08	TCGA-EM-A3FR-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bae2f08-da75-4991-acb8-5ba9912f9131	d2f5c569-964a-4cb4-a77e-a3df7bfbe36a	g.chr1:17914071G>A	uc001ban.3	+	2	313	c.154G>A	c.(154-156)Gtc>Atc	p.V52I	ARHGEF10L_uc009vpe.1_Missense_Mutation_p.V52I|ARHGEF10L_uc001bao.3_Missense_Mutation_p.V52I|ARHGEF10L_uc001bap.3_Missense_Mutation_p.V52I|ARHGEF10L_uc010ocr.1_5'Flank	NM_018125	NP_060595	Q9HCE6	ARGAL_HUMAN	Homo sapiens Rho guanine nucleotide exchange factor (GEF) 10-like (ARHGEF10L), transcript variant 1, mRNA.	52					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	43		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		AGCCCTGGGCGTCCCCAGCCT	0.597000													5	304					0	0	1	0	0
TTC36	143941	broad.mit.edu	37	11	118398234	118398234	+	Missense_Mutation	SNP	G	G	A			TCGA-EM-A3FR-01A-11D-A21Z-08	TCGA-EM-A3FR-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bae2f08-da75-4991-acb8-5ba9912f9131	d2f5c569-964a-4cb4-a77e-a3df7bfbe36a	g.chr11:118398234G>A	uc001ptg.1	+	0	25	c.25G>A	c.(25-27)Gtg>Atg	p.V9M	TTC36_uc010ryb.1_Non-coding_Transcript|TTC36_uc010ryc.1_5'UTR	NM_001080441	NP_001073910	A6NLP5	TTC36_HUMAN	Homo sapiens tetratricopeptide repeat domain 36 (TTC36), mRNA.	9							binding			lung(2)	2						TGATCAGGCAGTGCTGCAGGC	0.537000													4	285					0	0	1	0	0
ASAP2	8853	broad.mit.edu	37	2	9463306	9463306	+	Missense_Mutation	SNP	C	C	G			TCGA-EM-A3FR-01A-11D-A21Z-08	TCGA-EM-A3FR-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bae2f08-da75-4991-acb8-5ba9912f9131	d2f5c569-964a-4cb4-a77e-a3df7bfbe36a	g.chr2:9463306C>G	uc002qzh.2	+	5	867	c.527C>G	c.(526-528)aCt>aGt	p.T176S	ASAP2_uc002qzi.2_Missense_Mutation_p.T176S	NM_003887	NP_003878	O43150	ASAP2_HUMAN	Homo sapiens ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (ASAP2), transcript variant 1, mRNA.	176					regulation of ARF GTPase activity	Golgi cisterna membrane|plasma membrane	ARF GTPase activator activity|protein binding|zinc ion binding	p.R175L(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(6)|lung(15)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)	36						ATGATTCGGACTGAAATAAGC	0.498000													88	137					0	0	1	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140180926	140180926	+	Silent	SNP	C	C	A			TCGA-EM-A3FR-01A-11D-A21Z-08	TCGA-EM-A3FR-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bae2f08-da75-4991-acb8-5ba9912f9131	d2f5c569-964a-4cb4-a77e-a3df7bfbe36a	g.chr5:140180926C>A	uc003lhf.2	+	0	144	c.144C>A	c.(142-144)atC>atA	p.I48I	PCDHAC2_uc003lha.2_Intron|PCDHAC2_uc003lhb.2_Intron|PCDHAC2_uc003lhd.2_Intron|PCDHAC2_uc011czy.2_Intron|PCDHAC2_uc011czz.2_Silent_p.I48I	NM_018906	NP_061729	Q9Y5I4	PCDC2_HUMAN	Homo sapiens protocadherin alpha 3 (PCDHA3), transcript variant 1, mRNA.	61	Cadherin 1.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGGCCGCATCGCGCAGGACC	0.647000													4	142					0	0	1	0	0
LCT	3938	broad.mit.edu	37	2	136574959	136574959	+	Silent	SNP	G	G	A	rs142388926		TCGA-EM-A3FR-01A-11D-A21Z-08	TCGA-EM-A3FR-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bae2f08-da75-4991-acb8-5ba9912f9131	d2f5c569-964a-4cb4-a77e-a3df7bfbe36a	g.chr2:136574959G>A	uc002tuu.1	-	5	1670	c.1659C>T	c.(1657-1659)acC>acT	p.T553T		NM_002299	NP_002290	P09848	LPH_HUMAN	Homo sapiens lactase (LCT), mRNA.	553	4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			breast(6)|central_nervous_system(3)|cervix(1)|endometrium(8)|kidney(2)|large_intestine(26)|lung(57)|ovary(7)|pancreas(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(4)	124				BRCA - Breast invasive adenocarcinoma(221;0.169)		GGTGCTGGCCGGTGCCATAGC	0.572000													3	94					0	0	1	0	0
TG	7038	broad.mit.edu	37	8	133899146	133899149	+	Frame_Shift_Del	DEL	TGAA	TGAA	-			TCGA-EM-A3FR-01A-11D-A21Z-08	TCGA-EM-A3FR-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bae2f08-da75-4991-acb8-5ba9912f9131	d2f5c569-964a-4cb4-a77e-a3df7bfbe36a	g.chr8:133899146_133899149delTGAA	uc003ytw.3	+	8	1570_1573	c.1529_1532delTGAA	c.(1528-1533)ttgaatfs	p.L510fs		NM_003235	NP_003226	P01266	THYG_HUMAN	Homo sapiens thyroglobulin (TG), mRNA.	510					hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			NS(1)|breast(11)|central_nervous_system(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(34)|liver(2)|lung(59)|ovary(9)|pancreas(2)|prostate(6)|skin(7)|stomach(4)|upper_aerodigestive_tract(4)|urinary_tract(8)	168	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GCAAGCTTCTTGAATGGAGGGAGA	0.451													35	54	---	---	---	---					
PTPRD	5789	broad.mit.edu	37	9	8733812	8733814	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-EM-A3FR-01A-11D-A21Z-08	TCGA-EM-A3FR-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	4bae2f08-da75-4991-acb8-5ba9912f9131	d2f5c569-964a-4cb4-a77e-a3df7bfbe36a	g.chr9:8733812_8733814delAGC	uc003zkk.3	-	11	773_775	c.30_32delGCT	c.(28-33)ctgctc>ctc	p.10_11LL>L	PTPRD_uc003zkp.3_In_Frame_Del_p.10_11LL>L|PTPRD_uc003zkq.3_In_Frame_Del_p.10_11LL>L|PTPRD_uc003zkr.3_In_Frame_Del_p.10_11LL>L|PTPRD_uc003zks.3_In_Frame_Del_p.10_11LL>L|PTPRD_uc022bdj.1_In_Frame_Del_p.10_11LL>L|PTPRD_uc003zkt.1_In_Frame_Del_p.10_11LL>L	NM_002839	NP_002830	P23468	PTPRD_HUMAN	Homo sapiens protein tyrosine phosphatase, receptor type, D (PTPRD), transcript variant 1, mRNA.	10					transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(7)|central_nervous_system(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|liver(1)|lung(83)|ovary(4)|pancreas(1)|prostate(7)|skin(19)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(1)	168		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GAAAGTGAGGAGCAGCAGCAGCA	0.591										TSP Lung(15;0.13)			2	4	---	---	---	---					
