Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
AADACL4	343066	broad.mit.edu	37	1	12726726	12726726	+	Missense_Mutation	SNP	A	A	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr1:12726726A>T	uc001auf.2	+	4	1204	c.1204A>T	c.(1204-1206)AGT>TGT	p.S402C		NM_001013630	NP_001013652	Q5VUY2	ADCL4_HUMAN	arylacetamide deacetylase-like 4	402	Lumenal (Potential).					integral to membrane	carboxylesterase activity				0	Ovarian(185;0.249)	Renal(390;0.000469)|Lung NSC(185;0.000937)|all_lung(284;0.00122)|Colorectal(325;0.00215)|Breast(348;0.0042)|Myeloproliferative disorder(586;0.0393)|Hepatocellular(190;0.0623)|Ovarian(437;0.0731)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;6.81e-07)|COAD - Colon adenocarcinoma(227;0.000274)|BRCA - Breast invasive adenocarcinoma(304;0.000311)|Kidney(185;0.00217)|KIRC - Kidney renal clear cell carcinoma(229;0.00579)|STAD - Stomach adenocarcinoma(313;0.00743)|READ - Rectum adenocarcinoma(331;0.0384)		TGCTGTAGTCAGTTATATAAA	0.438		NaN											0	0	0	0.021553	0	5	85									
EIF4G3	8672	broad.mit.edu	37	1	21143902	21143902	+	Missense_Mutation	SNP	T	T	C			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr1:21143902T>C	uc001bec.2	-	29	4586	c.4330A>G	c.(4330-4332)ATC>GTC	p.I1444V	EIF4G3_uc010odi.1_Missense_Mutation_p.I1048V|EIF4G3_uc010odj.1_Missense_Mutation_p.I1443V|EIF4G3_uc009vpz.2_Missense_Mutation_p.I1164V|EIF4G3_uc001bed.2_Missense_Mutation_p.I1444V|EIF4G3_uc001bef.2_Missense_Mutation_p.I1480V|EIF4G3_uc001bee.2_Missense_Mutation_p.I1450V	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	1444	EIF4A-binding (By similarity).|W2.				interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		CAGTCAAAGATCTGTTCATCA	0.428		NaN											0	0	0	0.139131	0	45	43									
ZNF643	65243	broad.mit.edu	37	1	40928396	40928396	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr1:40928396G>C	uc001cfn.1	+	5	1037	c.740G>C	c.(739-741)AGA>ACA	p.R247T	ZNF643_uc001cfl.1_Missense_Mutation_p.R145T|ZNF643_uc001cfm.1_Missense_Mutation_p.R113T	NM_023070	NP_075558	Q9UJL9	ZN643_HUMAN	zinc finger protein 643	247					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;5.25e-18)			GGTCTTCCAAGAAAAAGAGAT	0.348		NaN											0	0	0	0.139131	0	53	57									
SARS	6301	broad.mit.edu	37	1	109777922	109777922	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr1:109777922C>T	uc001dwu.1	+	7	913	c.838C>T	c.(838-840)CAC>TAC	p.H280Y	SARS_uc001dwt.1_Missense_Mutation_p.H280Y|SARS_uc001dwv.1_Missense_Mutation_p.H280Y|SARS_uc001dww.1_Missense_Mutation_p.H213Y|SARS_uc001dwx.1_Missense_Mutation_p.H232Y|SARS_uc009wfa.1_Missense_Mutation_p.H280Y|SARS_uc001dwy.1_Missense_Mutation_p.H105Y|SARS_uc001dwz.1_Missense_Mutation_p.H105Y	NM_006513	NP_006504	P49591	SYSC_HUMAN	seryl-tRNA synthetase	280					seryl-tRNA aminoacylation|tRNA processing	cytosol	ATP binding|protein binding|RNA binding|serine-tRNA ligase activity			central_nervous_system(1)	1		all_epithelial(167;7.64e-05)|all_lung(203;0.000321)|Lung NSC(277;0.000626)|Breast(1374;0.244)		Colorectal(144;0.0301)|Lung(183;0.0677)|COAD - Colon adenocarcinoma(174;0.116)|Epithelial(280;0.233)	L-Serine(DB00133)	TGCTGCCCTGCACCGGGATGA	0.587		NaN											0	0	0	0.139131	0	51	79									
LCE3D	84648	broad.mit.edu	37	1	152552263	152552263	+	Silent	SNP	G	G	A	rs139649941		TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr1:152552263G>A	uc001fab.2	-	2	207	c.150C>T	c.(148-150)GGC>GGT	p.G50G		NM_032563	NP_115952	Q9BYE3	LCE3D_HUMAN	late cornified envelope 3D	50					keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)	UCEC - Uterine corpus endometrioid carcinoma (5;0.153)|KIRC - Kidney renal clear cell carcinoma(4;0.0323)|Kidney(5;0.0378)		GGAAGCAGCCGCCCTCGGAGC	0.672		NaN											0	0	0	0.047766	0	9	67									
TMCC2	9911	broad.mit.edu	37	1	205210891	205210891	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr1:205210891C>T	uc001hbz.1	+	3	910	c.466C>T	c.(466-468)CGC>TGC	p.R156C	TMCC2_uc010prf.1_Missense_Mutation_p.R78C	NM_014858	NP_055673	O75069	TMCC2_HUMAN	transmembrane and coiled-coil domain family 2	156						integral to membrane	protein binding			pancreas(1)	1	Breast(84;0.0871)		BRCA - Breast invasive adenocarcinoma(75;0.117)			GCAGCAGATCCGCTCCCGGCC	0.507		NaN											0	0	0	0.058154	0	7	18									
NLRP3	114548	broad.mit.edu	37	1	247607294	247607294	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr1:247607294C>T	uc001icr.2	+	9	2828	c.2690C>T	c.(2689-2691)ACG>ATG	p.T897M	NLRP3_uc001ics.2_Missense_Mutation_p.T840M|NLRP3_uc001icu.2_Missense_Mutation_p.T897M|NLRP3_uc001icw.2_Missense_Mutation_p.T840M|NLRP3_uc001icv.2_Missense_Mutation_p.T783M|NLRP3_uc010pyw.1_Missense_Mutation_p.T875M	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	897	LRR 6.				detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			TCTGGCCTTACGTCAGTCTGT	0.512		NaN											0	0	0	0.043863	0	19	30									
ANUBL1	93550	broad.mit.edu	37	10	46121709	46121709	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr10:46121709G>A	uc001jcp.3	-	7	1804	c.1562C>T	c.(1561-1563)TCT>TTT	p.S521F	ANUBL1_uc001jcl.3_Missense_Mutation_p.S41F|ANUBL1_uc001jcm.3_Missense_Mutation_p.S521F|ANUBL1_uc009xmu.2_Missense_Mutation_p.S447F|ANUBL1_uc001jcn.3_Missense_Mutation_p.S447F|ANUBL1_uc001jco.3_Intron	NM_001128324	NP_001121796	Q86XD8	ANUB1_HUMAN	AN1, ubiquitin-like, homolog	521							zinc ion binding				0						AGTAGTCCTAGAGAAAGAAGA	0.393		NaN											0	0	0	0.021553	0	5	69									
OR6Q1	219952	broad.mit.edu	37	11	57798438	57798438	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr11:57798438C>T	uc010rjz.1	+	1	14	c.14C>T	c.(13-15)ACC>ATC	p.T5I	OR9Q1_uc001nmj.2_Intron	NM_001005186	NP_001005186	Q8NGQ2	OR6Q1_HUMAN	olfactory receptor, family 6, subfamily Q,	5	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			kidney(1)	1		Breast(21;0.0707)|all_epithelial(135;0.142)				CAACCATATACCAAAAACTGG	0.458		NaN											0	0	0	0.047766	0	8	205									
WNK1	65125	broad.mit.edu	37	12	1017767	1017767	+	Missense_Mutation	SNP	A	A	G	rs144574284	by1000genomes	TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr12:1017767A>G	uc001qio.3	+	28	7465	c.6958A>G	c.(6958-6960)ATG>GTG	p.M2320V	WNK1_uc001qip.3_Missense_Mutation_p.M2072V|WNK1_uc001qir.3_Missense_Mutation_p.M1493V	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	2320					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			CACCAAGTCTATGTGCCCCCC	0.592		NaN											0	0	0	0.139131	0	64	40									
DCP1B	196513	broad.mit.edu	37	12	2062350	2062350	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr12:2062350C>G	uc001qjx.1	-	7	836	c.756G>C	c.(754-756)CAG>CAC	p.Q252H	DCP1B_uc010sdy.1_Missense_Mutation_p.Q150H	NM_152640	NP_689853	Q8IZD4	DCP1B_HUMAN	decapping enzyme Dcp1b	252	Poly-Gln.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	hydrolase activity|protein binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(31;0.00193)			gctgctgctgctgGTGGAGAG	0.458		NaN											0	0	0	0.150653	0	3	70									
GALNT8	26290	broad.mit.edu	37	12	4835915	4835915	+	Silent	SNP	C	C	G			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr12:4835915C>G	uc001qne.1	+	2	521	c.429C>G	c.(427-429)CTC>CTG	p.L143L		NM_017417	NP_059113	Q9NY28	GALT8_HUMAN	polypeptide N-acetylgalactosaminyltransferase 8	143	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)|pancreas(1)|skin(1)	4						CCCAGGACCTCTTCCGGAAGT	0.557		NaN											0	0	0	0.139131	0	85	44									
SLC2A13	114134	broad.mit.edu	37	12	40499377	40499377	+	Silent	SNP	G	G	A			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr12:40499377G>A	uc010skm.1	-	1	285	c.234C>T	c.(232-234)CCC>CCT	p.P78P	SLC2A13_uc001rmf.2_Silent_p.P78P	NM_052885	NP_443117	Q96QE2	MYCT_HUMAN	solute carrier family 2 (facilitated glucose	78	Helical; Name=1; (Potential).					integral to membrane|plasma membrane	myo-inositol:hydrogen symporter activity			ovary(1)	1		Lung NSC(34;0.105)|all_lung(34;0.123)				ACACGAAGGCGGGGGTCTCGT	0.478		NaN								HNSCC(50;0.14)			0	0	0	0.058154	0	6	7									
GIT2	9815	broad.mit.edu	37	12	110391020	110391020	+	Silent	SNP	C	C	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr12:110391020C>T	uc001tps.2	-	13	1284	c.1119G>A	c.(1117-1119)CTG>CTA	p.L373L	TCHP_uc001tpo.1_RNA|GIT2_uc001tpr.2_5'UTR|GIT2_uc001tpq.2_Silent_p.L373L|GIT2_uc001tpv.2_Silent_p.L375L|GIT2_uc001tpu.2_Silent_p.L373L|GIT2_uc001tpt.2_Silent_p.L373L|GIT2_uc010sxu.1_Silent_p.L311L|GIT2_uc001tpw.2_Silent_p.L373L|GIT2_uc010sxv.1_Silent_p.L373L	NM_057169	NP_476510	Q14161	GIT2_HUMAN	G protein-coupled receptor kinase interacting	373					regulation of ARF GTPase activity|regulation of G-protein coupled receptor protein signaling pathway	nucleoplasm	ARF GTPase activator activity|protein binding|zinc ion binding			central_nervous_system(1)	1						TGATGGTTTTCAGTATGAGCT	0.413		NaN											0	0	0	0.139131	0	48	134									
POU4F1	5457	broad.mit.edu	37	13	79175754	79175754	+	Silent	SNP	G	G	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr13:79175754G>T	uc001vkv.2	-	2	1290	c.1056C>A	c.(1054-1056)GGC>GGA	p.G352G	uc001vku.1_Intron	NM_006237	NP_006228	Q01851	PO4F1_HUMAN	POU domain, class 4, transcription factor 1	352					axonogenesis|regulation of transcription from RNA polymerase II promoter|synapse assembly	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)|Breast(118;0.0848)		GBM - Glioblastoma multiforme(99;0.129)		TCTTCTCGCCGCCGTTGAAGA	0.652		NaN											1	0	0.000157383	0.038147	0.00016443	7	24									
ZFYVE19	84936	broad.mit.edu	37	15	41105570	41105570	+	Silent	SNP	T	T	C			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr15:41105570T>C	uc001zmt.1	+	8	1579	c.1065T>C	c.(1063-1065)GAT>GAC	p.D355D	ZFYVE19_uc001zmu.1_Silent_p.D287D|ZFYVE19_uc001zmv.1_Silent_p.D180D|ZFYVE19_uc001zmw.1_Silent_p.D180D|ZFYVE19_uc001zmx.1_Silent_p.D180D|ZFYVE19_uc010bcc.1_Silent_p.D180D	NM_001077268	NP_001070736	Q96K21	ZFY19_HUMAN	zinc finger, FYVE domain containing 19	355	Potential.						zinc ion binding				0		all_cancers(109;3.31e-18)|all_epithelial(112;2.33e-15)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.0946)		GBM - Glioblastoma multiforme(113;2.76e-05)|COAD - Colon adenocarcinoma(120;0.151)|BRCA - Breast invasive adenocarcinoma(123;0.164)		CAGACAGTGATGACGACGAGG	0.587		NaN											0	0	0	0.09319	0	9	23									
ANXA2	302	broad.mit.edu	37	15	60641322	60641322	+	Missense_Mutation	SNP	C	C	A			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr15:60641322C>A	uc002agn.2	-	13	1072	c.912G>T	c.(910-912)AGG>AGT	p.R304S	ANXA2_uc002agk.2_Missense_Mutation_p.R304S|ANXA2_uc002agl.2_Missense_Mutation_p.R304S|ANXA2_uc002agm.2_Missense_Mutation_p.R322S|ANXA2_uc010uhd.1_RNA	NM_001136015	NP_001129487	P07355	ANXA2_HUMAN	annexin A2 isoform 2	304	Annexin 4.				angiogenesis|positive regulation of vesicle fusion|skeletal system development	basement membrane|melanosome|midbody|soluble fraction	calcium ion binding|calcium-dependent phospholipid binding|cytoskeletal protein binding|phospholipase inhibitor activity			ovary(1)	1					Alteplase(DB00009)|Anistreplase(DB00029)|Tenecteplase(DB00031)	TGAATTCAGACCTAATTTTCA	0.502		NaN											1	0	3.27435e-08	0.11911	3.4728e-08	14	57									
C15orf39	56905	broad.mit.edu	37	15	75501097	75501097	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr15:75501097G>A	uc002azp.3	+	2	3028	c.2708G>A	c.(2707-2709)CGC>CAC	p.R903H	C15orf39_uc002azq.3_Missense_Mutation_p.R903H|C15orf39_uc002azr.3_Missense_Mutation_p.R301H	NM_015492	NP_056307	Q6ZRI6	CO039_HUMAN	hypothetical protein LOC56905	903											0						CTGGCGCTGCGCCAGCTGCCG	0.697		NaN											0	0	0	0.144211	0	22	19									
ADAMTSL3	57188	broad.mit.edu	37	15	84651669	84651669	+	Missense_Mutation	SNP	G	G	C			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr15:84651669G>C	uc002bjz.3	+	21	3513	c.3289G>C	c.(3289-3291)GAT>CAT	p.D1097H	ADAMTSL3_uc010bmt.1_Missense_Mutation_p.D1097H|ADAMTSL3_uc010bmu.1_Missense_Mutation_p.D1097H	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	1097						proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			AGCCCAGTTTGATGAGCTGAT	0.473		NaN											0	0	0	0.183431	0	31	64									
PITPNC1	26207	broad.mit.edu	37	17	65671602	65671602	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr17:65671602G>A	uc002jgc.2	+	8	973	c.626G>A	c.(625-627)CGA>CAA	p.R209Q	PITPNC1_uc002jgb.2_Missense_Mutation_p.R209Q	NM_012417	NP_036549	Q9UKF7	PITC1_HUMAN	phosphatidylinositol transfer protein,	209					signal transduction	cytoplasm	lipid binding|phosphatidylinositol transporter activity|protein binding			skin(1)	1	all_cancers(12;3.03e-10)		BRCA - Breast invasive adenocarcinoma(8;2.08e-08)|Colorectal(3;0.198)			TAGGTGGTCCGAGACATTCTG	0.373		NaN											0	0	0	0.175082	0	15	96									
DOT1L	84444	broad.mit.edu	37	19	2220125	2220125	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr19:2220125G>A	uc002lvb.3	+	23	2746	c.2710G>A	c.(2710-2712)GTG>ATG	p.V904M	DOT1L_uc002lvc.1_Missense_Mutation_p.V198M|DOT1L_uc002lve.1_Missense_Mutation_p.V198M	NM_032482	NP_115871	Q8TEK3	DOT1L_HUMAN	DOT1-like, histone H3 methyltransferase	904						nucleus	DNA binding|histone-lysine N-methyltransferase activity|protein binding			pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	4		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCCAGTCCCGTGCTGCAGCC	0.617		NaN											0	0	0	0.02938	0	5	75									
MUC16	94025	broad.mit.edu	37	19	9090831	9090831	+	Silent	SNP	A	A	G			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr19:9090831A>G	uc002mkp.2	-	1	1188	c.984T>C	c.(982-984)CCT>CCC	p.P328P		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	328	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCATGGAAAAAGGGATAGCTG	0.522		NaN											0	0	0	0.115264	0	3	86									
CILP2	148113	broad.mit.edu	37	19	19655933	19655933	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr19:19655933G>A	uc002nmv.3	+	8	2664	c.2579G>A	c.(2578-2580)CGC>CAC	p.R860H	CILP2_uc002nmw.3_Missense_Mutation_p.R866H	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	860						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						AACGGCTTCCGCATCAACCTC	0.701		NaN											0	0	0	0.150653	0	4	76									
ZNF737	100129842	broad.mit.edu	37	19	20728097	20728097	+	Silent	SNP	C	C	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr19:20728097C>T	uc002npa.2	-	4	1092	c.912G>A	c.(910-912)AAG>AAA	p.K304K		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	304					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						TATGAATTATCTTATGCGCAG	0.408		NaN											0	0	0	0.153744	0	30	44									
ZNF681	148213	broad.mit.edu	37	19	23927314	23927314	+	Silent	SNP	G	G	A			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr19:23927314G>A	uc002nrk.3	-	4	1180	c.1038C>T	c.(1036-1038)GCC>GCT	p.A346A	ZNF681_uc002nrl.3_Silent_p.A277A|ZNF681_uc002nrj.3_Silent_p.A277A	NM_138286	NP_612143	Q96N22	ZN681_HUMAN	zinc finger protein 681	346	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				ACTGGTTAAAGGCTTTGCCAC	0.433		NaN											0	0	0	0.047766	0	5	158									
ATP4A	495	broad.mit.edu	37	19	36050775	36050775	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr19:36050775G>A	uc002oal.1	-	7	1017	c.988C>T	c.(988-990)CGG>TGG	p.R330W	ATP4A_uc010eee.1_5'Flank	NM_000704	NP_000695	P20648	ATP4A_HUMAN	hydrogen/potassium-exchanging ATPase 4A	330	Lumenal (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			ovary(1)	1	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	ACCATGGCCCGCAGGAAGGTG	0.577		NaN											0	0	0	0.099896	0	27	27									
CATSPERG	57828	broad.mit.edu	37	19	38847487	38847487	+	Missense_Mutation	SNP	T	T	C			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr19:38847487T>C	uc002oih.3	+	11	1388	c.1301T>C	c.(1300-1302)GTC>GCC	p.V434A	CATSPERG_uc002oig.3_Intron|CATSPERG_uc002oif.3_Missense_Mutation_p.V74A|CATSPERG_uc010efw.2_RNA	NM_021185	NP_067008	Q6ZRH7	CTSRG_HUMAN	cation channel, sperm-associated, gamma	434	Extracellular (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(1)|skin(1)	2						TTCCAGGTGGTCAGCTACAAC	0.527		NaN											0	0	0	0.139131	0	74	99									
CYP2B6	1555	broad.mit.edu	37	19	41518645	41518645	+	Missense_Mutation	SNP	G	G	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr19:41518645G>T	uc002opr.1	+	8	1226	c.1219G>T	c.(1219-1221)GCC>TCC	p.A407S	CYP2A7_uc002opo.2_Intron|CYP2B6_uc010xvu.1_Missense_Mutation_p.A207S	NM_000767	NP_000758	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B,	407					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	AAAACCAGACGCCTTCAATCC	0.458		NaN											1	0	1.16149e-67	0.139131	1.33286e-67	109	101									
KLK15	55554	broad.mit.edu	37	19	51330226	51330226	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr19:51330226C>T	uc002ptl.2	-	3	420	c.389G>A	c.(388-390)CGT>CAT	p.R130H	KLK15_uc002ptm.2_Intron|KLK15_uc002ptn.2_Missense_Mutation_p.R130H|KLK15_uc002pto.2_Missense_Mutation_p.R129H|KLK15_uc010ych.1_Intron|KLK15_uc010yci.1_Missense_Mutation_p.R129H|KLK15_uc010eod.2_RNA	NM_017509	NP_059979	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15 isoform 4	130	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)|breast(1)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		GTGGGGGCAACGCGTGGGTAG	0.706		NaN											0	0	0	0.173368	0	29	34									
TTN	7273	broad.mit.edu	37	2	179394807	179394807	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr2:179394807C>G	uc010zfg.1	-	308	98931	c.98707G>C	c.(98707-98709)GAC>CAC	p.D32903H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D26598H|TTN_uc010zfi.1_Missense_Mutation_p.D26531H|TTN_uc010zfj.1_Missense_Mutation_p.D26406H|TTN_uc002umq.2_5'Flank	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	33830							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CCTCCCTTGTCTTCAGAGAGT	0.348		NaN											0	0	0	0.146539	0	13	26									
TTN	7273	broad.mit.edu	37	2	179428319	179428319	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr2:179428319C>T	uc010zfg.1	-	275	75060	c.74836G>A	c.(74836-74838)GTT>ATT	p.V24946I	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.V18641I|TTN_uc010zfi.1_Missense_Mutation_p.V18574I|TTN_uc010zfj.1_Missense_Mutation_p.V18449I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	25873							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTCCATCTAACGCCTTCCTTA	0.463		NaN											0	0	0	0.139131	0	59	65									
C2orf66	401027	broad.mit.edu	37	2	197672317	197672317	+	Silent	SNP	C	C	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr2:197672317C>T	uc002utv.2	-	2	1093	c.204G>A	c.(202-204)AAG>AAA	p.K68K		NM_213608	NP_998773	Q6UXQ4	CB066_HUMAN	hypothetical protein LOC401027 precursor	68						extracellular region					0						GACCTCTGCCCTTAAAATATG	0.388		NaN											0	0	0	0.139131	0	41	74									
ANKRD44	91526	broad.mit.edu	37	2	197975551	197975551	+	Missense_Mutation	SNP	A	A	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr2:197975551A>T	uc002uuc.2	-	9	1091	c.924T>A	c.(922-924)AGT>AGA	p.S308R	ANKRD44_uc002utz.3_5'UTR|ANKRD44_uc002uua.1_Missense_Mutation_p.S283R|ANKRD44_uc002uub.2_Missense_Mutation_p.S308R|ANKRD44_uc010zgw.1_Missense_Mutation_p.S236R	NM_153697	NP_710181	Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	308	ANK 10.						protein binding			ovary(4)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.246)			TGTGCAGTGGACTTTTGCCAT	0.448		NaN											0	0	0	0.047766	0	8	166									
ATG16L1	55054	broad.mit.edu	37	2	234183394	234183394	+	Silent	SNP	G	G	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr2:234183394G>T	uc002vty.2	+	9	1181	c.924G>T	c.(922-924)GTG>GTT	p.V308V	ATG16L1_uc002vtx.1_Silent_p.V145V|ATG16L1_uc002vua.2_Silent_p.V289V|ATG16L1_uc002vub.2_Silent_p.V166V|ATG16L1_uc002vtz.2_Silent_p.V164V|ATG16L1_uc002vud.3_Silent_p.V224V|SCARNA5_uc002vue.1_5'Flank	NM_030803	NP_110430	Q676U5	A16L1_HUMAN	APG16 autophagy 16-like isoform 1	308					autophagic vacuole assembly|protein homooligomerization|protein transport	autophagic vacuole|pre-autophagosomal structure membrane	protein binding				0		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0539)		Epithelial(121;1.53e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000379)|LUSC - Lung squamous cell carcinoma(224;0.00619)|Lung(119;0.00732)|GBM - Glioblastoma multiforme(43;0.11)		GTAAAGAAGTGAGGGTACCAG	0.473		NaN											1	0	2.35958e-20	0.11126	2.66405e-20	34	34									
KRTAP27-1	643812	broad.mit.edu	37	21	31709534	31709534	+	Silent	SNP	G	G	A			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr21:31709534G>A	uc002ynx.1	-	1	479	c.453C>T	c.(451-453)TTC>TTT	p.F151F		NM_001077711	NP_001071179	Q3LI81	KR271_HUMAN	keratin associated protein 27-1	151						intermediate filament		p.F151S(1)		ovary(2)	2						CCAGAGTTTCGAAATTTTTAG	0.493		NaN											0	0	0	0.139131	0	81	100									
UMODL1	89766	broad.mit.edu	37	21	43519101	43519101	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr21:43519101C>T	uc002zaf.1	+	7	997	c.997C>T	c.(997-999)CGT>TGT	p.R333C	UMODL1_uc002zad.1_Missense_Mutation_p.R261C|UMODL1_uc002zae.1_Missense_Mutation_p.R261C|UMODL1_uc002zag.1_Missense_Mutation_p.R333C|UMODL1_uc010gow.1_Missense_Mutation_p.R125C|UMODL1_uc002zai.1_5'UTR|UMODL1_uc010gox.1_RNA|UMODL1_uc010goy.1_5'UTR|UMODL1_uc002zaj.1_RNA|UMODL1_uc010goz.1_Missense_Mutation_p.R78C	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	333	Extracellular (Potential).|Fibronectin type-III 1.					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						AGTATCCTGGCGTTTAAATTC	0.522		NaN											0	0	0	0.014758	0	5	119									
TRPM2	7226	broad.mit.edu	37	21	45784025	45784025	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr21:45784025C>T	uc002zet.1	+	4	496	c.283C>T	c.(283-285)CAT>TAT	p.H95Y	TRPM2_uc002zeu.1_Missense_Mutation_p.H95Y|TRPM2_uc002zew.1_Missense_Mutation_p.H95Y|TRPM2_uc010gpt.1_Missense_Mutation_p.H95Y	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	95	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						TGGCTACACGCATGAGCAGCA	0.423		NaN											0	0	0	0.083992	0	23	23									
MASP1	5648	broad.mit.edu	37	3	186968087	186968087	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr3:186968087C>G	uc003frh.1	-	8	1374	c.1042G>C	c.(1042-1044)GAG>CAG	p.E348Q	MASP1_uc003fri.2_Missense_Mutation_p.E348Q|MASP1_uc003frj.2_Missense_Mutation_p.E317Q|MASP1_uc003frk.1_Missense_Mutation_p.E348Q|MASP1_uc011bse.1_Missense_Mutation_p.E322Q	NM_001879	NP_001870	P48740	MASP1_HUMAN	mannan-binding lectin serine protease 1 isoform	348	Sushi 1.				complement activation, lectin pathway|negative regulation of complement activation|proteolysis	extracellular space	calcium ion binding|calcium-dependent protein binding|protein binding|protein homodimerization activity|serine-type endopeptidase activity			ovary(2)|breast(1)|liver(1)	4	all_cancers(143;5.33e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.49e-18)	GBM - Glioblastoma multiforme(93;0.0366)		TTCAGACACTCAATCTGGAAT	0.393		NaN											0	0	0	0.139131	0	79	136									
WHSC2	7469	broad.mit.edu	37	4	1985711	1985711	+	Missense_Mutation	SNP	G	G	A	rs149343602		TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr4:1985711G>A	uc003gem.2	-	9	1439	c.1199C>T	c.(1198-1200)GCG>GTG	p.A400V	WHSC2_uc003gek.2_Missense_Mutation_p.A126V|WHSC2_uc003gel.2_Missense_Mutation_p.A314V|WHSC2_uc003gen.2_Missense_Mutation_p.A254V	NM_005663	NP_005654	Q9H3P2	NELFA_HUMAN	Wolf-Hirschhorn syndrome candidate 2 protein	389					multicellular organismal development|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm				skin(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0155)			GGTGGGCGCCGCAGGCGTGGG	0.716		NaN											0	0	0	0.014758	0	3	34									
ADH6	130	broad.mit.edu	37	4	100137347	100137347	+	Missense_Mutation	SNP	G	G	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr4:100137347G>T	uc003hup.3	-	2	185	c.91C>A	c.(91-93)CCA>ACA	p.P31T	uc003hum.1_Intron|ADH6_uc003huo.2_Missense_Mutation_p.P31T|ADH6_uc011cef.1_5'UTR|ADH6_uc010ile.2_Missense_Mutation_p.P31T	NM_000672	NP_000663	P28332	ADH6_HUMAN	class V alcohol dehydrogenase isoform 2	31					ethanol oxidation|response to ethanol|xenobiotic metabolic process	cytosol	alcohol dehydrogenase (NAD) activity|electron carrier activity|zinc ion binding			ovary(1)|kidney(1)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(123;3.58e-08)	Abacavir(DB01048)|NADH(DB00157)	GCCTTTGGTGGGGCCACTTCT	0.403		NaN											1	0	6.45866e-13	0.104719	7.06416e-13	32	45									
F11	2160	broad.mit.edu	37	4	187209661	187209661	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr4:187209661G>A	uc003iza.1	+	15	2104	c.1771G>A	c.(1771-1773)GGC>AGC	p.G591S	uc003izb.1_RNA	NM_000128	NP_000119	P03951	FA11_HUMAN	coagulation factor XI precursor	591	Peptidase S1.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity				0		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	GCATCTGGTAGGCATCACGAG	0.552		NaN											0	0	0	0.139131	0	53	82									
PSMB9	5698	broad.mit.edu	37	6	32825140	32825140	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr6:32825140G>A	uc003sga.2	+	4	268	c.193G>A	c.(193-195)GAC>AAC	p.D65N	PSMB9_uc011dqj.1_Intron	NM_148954	NP_683756	P28065	PSB9_HUMAN	proteasome beta 9 subunit isoform 2 proprotein	77					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity				0						AGCCGTGGCCGACATGGCCGC	0.602		NaN											0	0	0	0.014758	0	4	44									
THEMIS	387357	broad.mit.edu	37	6	128040858	128040858	+	Missense_Mutation	SNP	G	G	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr6:128040858G>T	uc003qbi.2	-	6	2188	c.1869C>A	c.(1867-1869)AGC>AGA	p.S623R	THEMIS_uc010kfa.2_Missense_Mutation_p.S526R|THEMIS_uc011ebt.1_Missense_Mutation_p.S662R|THEMIS_uc010kfb.2_Missense_Mutation_p.S588R	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform	623					negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						CCCCACGGTTGCTCCTTTCTT	0.438		NaN											1	0	2.52991e-16	0.139131	2.81101e-16	40	47									
C6orf192	116843	broad.mit.edu	37	6	133111328	133111328	+	Silent	SNP	T	T	C			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr6:133111328T>C	uc003qdw.1	-	3	419	c.267A>G	c.(265-267)GTA>GTG	p.V89V	C6orf192_uc011eco.1_Missense_Mutation_p.I13V	NM_052831	NP_439896	Q6NT16	CF192_HUMAN	hypothetical protein LOC116843	89	Helical; (Potential).				transmembrane transport	integral to membrane				ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(155;0.00303)|GBM - Glioblastoma multiforme(226;0.0265)		AGTTTCCAAATACCAAGGATG	0.313		NaN											0	0	0	0.014758	0	5	6									
PCLO	27445	broad.mit.edu	37	7	82451883	82451883	+	Missense_Mutation	SNP	T	T	C			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr7:82451883T>C	uc003uhx.2	-	20	15008	c.14719A>G	c.(14719-14721)ACC>GCC	p.T4907A	PCLO_uc003uhv.2_Missense_Mutation_p.T4907A|PCLO_uc003uht.1_Missense_Mutation_p.T349A|PCLO_uc003uhu.1_Missense_Mutation_p.T328A	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4769					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						TCCAGGTGGGTCTGAGTGACG	0.502		NaN											0	0	0	0.139131	0	77	165									
TNFRSF10A	8797	broad.mit.edu	37	8	23056899	23056899	+	Missense_Mutation	SNP	C	C	G			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr8:23056899C>G	uc003xda.2	-	8	959	c.894G>C	c.(892-894)GAG>GAC	p.E298D		NM_003844	NP_003835	O00220	TR10A_HUMAN	tumor necrosis factor receptor superfamily,	298	Cytoplasmic (Potential).				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors		caspase activator activity|death receptor activity|TRAIL binding|transcription factor binding			central_nervous_system(3)|ovary(2)|skin(1)	6		Prostate(55;0.0421)|Breast(100;0.14)		Colorectal(74;0.016)|COAD - Colon adenocarcinoma(73;0.0646)		TGCTCAGAATCTCGTTGTGAG	0.562		NaN											0	0	0	0.139131	0	67	11									
FAM110B	90362	broad.mit.edu	37	8	59059268	59059268	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr8:59059268C>T	uc003xtj.1	+	5	1359	c.479C>T	c.(478-480)GCG>GTG	p.A160V		NM_147189	NP_671722	Q8TC76	F110B_HUMAN	hypothetical protein LOC90362	160						microtubule organizing center|mitochondrion|nucleus				large_intestine(1)	1		all_epithelial(80;0.025)|all_lung(136;0.0274)|Lung NSC(129;0.0355)				CACTCCTTCGCGGAGTCCCTG	0.697		NaN											0	0	0	0.014758	0	5	18									
PREX2	80243	broad.mit.edu	37	8	68950493	68950493	+	Missense_Mutation	SNP	G	G	A			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr8:68950493G>A	uc003xxv.1	+	7	832	c.805G>A	c.(805-807)GAT>AAT	p.D269N	PREX2_uc003xxu.1_Missense_Mutation_p.D269N|PREX2_uc011lez.1_Missense_Mutation_p.D204N	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	269	PH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						TTTTCTTTTCGATAATCTTTT	0.398		NaN											0	0	0	0.083992	0	21	57									
TMEM55A	55529	broad.mit.edu	37	8	92008912	92008912	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr8:92008912C>T	uc003yes.2	-	6	826	c.600G>A	c.(598-600)ATG>ATA	p.M200I		NM_018710	NP_061180	Q8N4L2	TM55A_HUMAN	transmembrane protein 55A	200	Helical; (Potential).					integral to membrane|late endosome membrane|lysosomal membrane	hydrolase activity				0			BRCA - Breast invasive adenocarcinoma(11;0.033)			AAATACATATCATTCCAATGG	0.393		NaN											0	0	0	0.043863	0	14	36									
PDP1	54704	broad.mit.edu	37	8	94934837	94934837	+	Missense_Mutation	SNP	C	C	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr8:94934837C>T	uc003yge.2	+	2	819	c.550C>T	c.(550-552)CGG>TGG	p.R184W	PDP1_uc003ygf.2_Missense_Mutation_p.R209W|PDP1_uc010max.2_Missense_Mutation_p.R209W|PDP1_uc011lgm.1_Missense_Mutation_p.R184W|PDP1_uc011lgn.1_Missense_Mutation_p.R243W	NM_018444	NP_060914	Q9P0J1	PDP1_HUMAN	pyruvate dehyrogenase phosphatase catalytic	184					pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix|protein serine/threonine phosphatase complex	[pyruvate dehydrogenase (lipoamide)] phosphatase activity			ovary(1)|skin(1)|central_nervous_system(1)|pancreas(1)	4						GGAGAGCGGCCGGGCACTGCT	0.453		NaN											0	0	0	0.144211	0	29	49									
PKHD1L1	93035	broad.mit.edu	37	8	110448690	110448690	+	Splice_Site	SNP	T	T	C			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr8:110448690T>C	uc003yne.2	+	30	3731	c.3627_splice	c.e30+2	p.K1209_splice		NM_177531	NP_803875	Q86WI1	PKHL1_HUMAN	fibrocystin L precursor						immune response	cytosol|extracellular space|integral to membrane	receptor activity			ovary(9)|central_nervous_system(2)|large_intestine(1)|breast(1)|pancreas(1)	14			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			ACACCAAAAGTAAGGCCTCTG	0.393		NaN								HNSCC(38;0.096)			0	0	0	0.134883	0	26	14									
RANBP6	26953	broad.mit.edu	37	9	6012658	6012658	+	Missense_Mutation	SNP	T	T	G			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr9:6012658T>G	uc003zjr.2	-	1	2961	c.2950A>C	c.(2950-2952)ATA>CTA	p.I984L	RANBP6_uc011lmf.1_Missense_Mutation_p.I632L|RANBP6_uc003zjs.2_Missense_Mutation_p.I572L	NM_012416	NP_036548	O60518	RNBP6_HUMAN	RAN binding protein 6	984	HEAT 7.				protein transport	cytoplasm|nucleus	binding			ovary(3)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00522)|Lung(218;0.101)		ATCTTCCCTATTGCTGAGATA	0.363		NaN											0	0	0	0.021553	0	5	42									
TLR7	51284	broad.mit.edu	37	X	12905875	12905875	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chrX:12905875C>T	uc004cvc.2	+	3	2387	c.2248C>T	c.(2248-2250)CGA>TGA	p.R750*		NM_016562	NP_057646	Q9NYK1	TLR7_HUMAN	toll-like receptor 7 precursor	750	Extracellular (Potential).|LRR 26.				cellular response to mechanical stimulus|defense response to virus|I-kappaB phosphorylation|inflammatory response|innate immune response|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus	early phagosome|endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosome|plasma membrane	double-stranded RNA binding|single-stranded RNA binding|siRNA binding|transmembrane receptor activity			ovary(2)|lung(2)|breast(1)	5					Imiquimod(DB00724)	CTTCCAGTTGCGATATCTGGA	0.383		NaN											0	0	0	0.02938	0	7	53									
CEP290	80184	broad.mit.edu	37	12	88512304	88512305	+	Frame_Shift_Ins	INS	-	-	T	rs77980773		TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr12:88512304_88512305insT	uc001tar.2	-	17	2010_2011	c.1666_1667insA	c.(1666-1668)ATTfs	p.I556fs	CEP290_uc001tat.2_Frame_Shift_Ins_p.I318fs|CEP290_uc009zsl.1_RNA	NM_025114	NP_079390	O15078	CE290_HUMAN	centrosomal protein 290kDa	556	Potential.				cilium assembly|eye photoreceptor cell development|G2/M transition of mitotic cell cycle|hindbrain development|otic vesicle formation|positive regulation of transcription, DNA-dependent|pronephros development|protein transport	cell surface|centrosome|cytosol|nucleus|photoreceptor connecting cilium	protein binding			ovary(5)|breast(1)|pancreas(1)	7						CATTTGACGAATTTTTTTTTTC	0.312		NaN											NaN	NaN	NaN	NaN	NaN	3	6	---	---							
ANKFY1	51479	broad.mit.edu	37	17	4086731	4086732	+	Frame_Shift_Ins	INS	-	-	GC			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr17:4086731_4086732insGC	uc002fxq.1	-	14	1951_1952	c.1913_1914insGC	c.(1912-1914)GCAfs	p.A638fs	ANKFY1_uc002fxn.2_Frame_Shift_Ins_p.A680fs|ANKFY1_uc002fxo.2_Frame_Shift_Ins_p.A638fs|ANKFY1_uc002fxp.2_Frame_Shift_Ins_p.A637fs|ANKFY1_uc010ckp.2_Frame_Shift_Ins_p.A579fs	NM_016376	NP_057460	Q9P2R3	ANFY1_HUMAN	ankyrin repeat and FYVE domain containing 1	638	ANK 9.					endosome membrane	metal ion binding|protein binding			ovary(2)|skin(1)	3						GCAGGAAGAGTGCGCTCTTGCT	0.55		NaN											NaN	NaN	NaN	NaN	NaN	60	104	---	---							
CABLES1	91768	broad.mit.edu	37	18	20716015	20716023	+	In_Frame_Del	DEL	GGCGCCGGC	GGCGCCGGC	-			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr18:20716015_20716023delGGCGCCGGC	uc002kuc.2	+	1	289_297	c.289_297delGGCGCCGGC	c.(289-297)GGCGCCGGCdel	p.GAG97del	CABLES1_uc002kub.2_Intron	NM_001100619	NP_001094089	Q8TDN4	CABL1_HUMAN	Cdk5 and Abl enzyme substrate 1 isoform 2	97_99	Ala-rich.|Interacts with TDRD7 (By similarity).				blood coagulation|cell cycle|cell division|regulation of cell cycle|regulation of cell division	cytosol|nucleus	cyclin-dependent protein kinase regulator activity|protein binding			breast(1)	1	all_cancers(21;0.000102)|all_epithelial(16;2.48e-06)|Lung NSC(20;0.00696)|all_lung(20;0.0197)|Colorectal(14;0.0202)|Ovarian(20;0.127)					ggccaagccgggcgccggcggcgcctgcg	0.593		NaN											NaN	NaN	NaN	NaN	NaN	4	2	---	---							
HPS4	89781	broad.mit.edu	37	22	26868322	26868322	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr22:26868322delG	uc003acl.2	-	6	1106	c.447delC	c.(445-447)AACfs	p.N149fs	HPS4_uc003aci.2_Frame_Shift_Del_p.N144fs|HPS4_uc003acj.2_5'UTR|HPS4_uc003ack.2_5'UTR|HPS4_uc003acn.2_5'UTR|HPS4_uc010gvd.1_Frame_Shift_Del_p.N149fs|HPS4_uc003ach.2_5'UTR	NM_022081	NP_071364	Q9NQG7	HPS4_HUMAN	light ear protein isoform a	149					lysosome organization|positive regulation of eye pigmentation|protein stabilization|protein targeting	lysosome|melanosome|membrane fraction|platelet dense granule	protein homodimerization activity				0						GATCACTGGTGTTTTTCAGAA	0.393		NaN							Hermansky-Pudlak_syndrome				NaN	NaN	NaN	NaN	NaN	68	104	---	---							
SH3BP2	6452	broad.mit.edu	37	4	2831730	2831731	+	Frame_Shift_Ins	INS	-	-	C			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr4:2831730_2831731insC	uc003gfi.3	+	8	1217_1218	c.1097_1098insC	c.(1096-1098)GACfs	p.D366fs	SH3BP2_uc011bvp.1_Frame_Shift_Ins_p.D394fs|SH3BP2_uc003gfj.3_Frame_Shift_Ins_p.D423fs|SH3BP2_uc003gfk.3_Frame_Shift_Ins_p.D366fs|SH3BP2_uc003gfl.3_Frame_Shift_Ins_p.D299fs|SH3BP2_uc003gfm.3_Frame_Shift_Ins_p.D341fs	NM_001122681	NP_001116153	P78314	3BP2_HUMAN	SH3-domain binding protein 2 isoform a	366					signal transduction		SH3 domain binding|SH3/SH2 adaptor activity			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (64;0.164)		GCTGAAGAGGACCCCCCAAGGG	0.658		NaN							Cherubism				NaN	NaN	NaN	NaN	NaN	115	33	---	---							
HMGB2	3148	broad.mit.edu	37	4	174253235	174253240	+	In_Frame_Del	DEL	TCTTCA	TCTTCA	-			TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr4:174253235_174253240delTCTTCA	uc011ckc.1	-	4	741_746	c.621_626delTGAAGA	c.(619-627)GATGAAGAA>GAA	p.DE207del	HMGB2_uc003ita.3_In_Frame_Del_p.DE207del|HMGB2_uc003itb.2_In_Frame_Del_p.DE207del|HMGB2_uc003itc.2_3'UTR	NM_001130689	NP_001124161	P26583	HMGB2_HUMAN	high-mobility group box 2	207_208	Asp/Glu-rich (acidic).				base-excision repair, DNA ligation|cell chemotaxis|cellular response to lipopolysaccharide|DNA fragmentation involved in apoptotic nuclear change|DNA topological change|negative regulation of transcription, DNA-dependent|nucleosome assembly|phosphatidylinositol-mediated signaling|positive regulation of DNA binding|positive regulation of endothelial cell proliferation|positive regulation of erythrocyte differentiation|positive regulation of megakaryocyte differentiation|positive regulation of nuclease activity|positive regulation of transcription from RNA polymerase II promoter|V(D)J recombination	condensed chromosome|extracellular space|nucleolus|nucleoplasm|perinuclear region of cytoplasm|protein complex	chemoattractant activity|damaged DNA binding|DNA bending activity|double-stranded DNA binding|RAGE receptor binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding|transcription regulatory region DNA binding				0		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;9.58e-18)|Epithelial(43;3.75e-16)|OV - Ovarian serous cystadenocarcinoma(60;6.24e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		AGCCATTTAttcttcatcttcatcct	0.262		NaN											NaN	NaN	NaN	NaN	NaN	59	112	---	---							
KCNN2	3781	broad.mit.edu	37	5	113698631	113698632	+	In_Frame_Ins	INS	-	-	GCC	rs151038013	by1000genomes	TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr5:113698631_113698632insGCC	uc003kqo.2	+	1	616_617	c.159_160insGCC	c.(157-162)insGCC	p.58_59insA		NM_021614	NP_067627	Q9H2S1	KCNN2_HUMAN	small conductance calcium-activated potassium	58_59						integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			ovary(2)	2		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		CTGCAGCCGCTGCCGCCGCCGC	0.658		NaN											NaN	NaN	NaN	NaN	NaN	3	4	---	---							
SNAPC4	6621	broad.mit.edu	37	9	139277995	139277997	+	In_Frame_Del	DEL	GCT	GCT	-	rs35266724		TCGA-CF-A3MH-01A-11D-A20D-08	TCGA-CF-A3MH-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	8867b16f-cd05-41e9-b3ca-4c72a1ebeb70	8ad1181e-2e1d-40cb-a18d-9240b5ab1733	g.chr9:139277995_139277997delGCT	uc004chh.2	-	15	1633_1635	c.1624_1626delAGC	c.(1624-1626)AGCdel	p.S542del		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,	542					snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		CGTCCTCCTCgctgctgctgctg	0.473		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---							
