Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
EPHA8	2046	broad.mit.edu	37	1	22922604	22922604	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr1:22922604G>T	uc001bfx.1	+	9	1828	c.1703G>T	c.(1702-1704)TGT>TTT	p.C568F		NM_020526	NP_065387	P29322	EPHA8_HUMAN	ephrin receptor EphA8 isoform 1 precursor	568	Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			central_nervous_system(5)|breast(3)|lung(2)|large_intestine(1)|stomach(1)|skin(1)	13		Colorectal(325;3.46e-05)|Lung NSC(340;6.55e-05)|all_lung(284;9.87e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0227)|OV - Ovarian serous cystadenocarcinoma(117;7.29e-27)|Colorectal(126;1.61e-07)|COAD - Colon adenocarcinoma(152;1.14e-05)|GBM - Glioblastoma multiforme(114;1.74e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000554)|KIRC - Kidney renal clear cell carcinoma(1967;0.00272)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.199)		TGCAGGCACTGTGGCTACAGC	0.637		NaN											1	0	8.16277e-20	0.027894	8.86362e-20	40	50									
CSMD2	114784	broad.mit.edu	37	1	34209159	34209159	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr1:34209159G>A	uc001bxn.1	-	14	1804	c.1775C>T	c.(1774-1776)CCC>CTC	p.P592L	CSMD2_uc001bxm.1_Missense_Mutation_p.P632L	NM_052896	NP_443128	Q7Z408	CSMD2_HUMAN	CUB and Sushi multiple domains 2	592	Extracellular (Potential).|CUB 4.					integral to membrane|plasma membrane	protein binding			ovary(6)|skin(5)|pancreas(1)	12		Myeloproliferative disorder(586;0.0294)|all_neural(195;0.249)				TGGGTAGTTGGGAGACAGGAC	0.572		NaN											0	0	0	0.038147	0	8	102									
BNIPL	149428	broad.mit.edu	37	1	151018593	151018593	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr1:151018593C>A	uc001ewl.2	+	9	1162	c.989C>A	c.(988-990)GCC>GAC	p.A330D	BNIPL_uc009wmi.2_Missense_Mutation_p.A248D|BNIPL_uc009wmj.2_RNA|C1orf56_uc001ewn.2_5'Flank	NM_138278	NP_612122	Q7Z465	BNIPL_HUMAN	BCL2/adenovirus E1B 19kD interacting protein	330	CRAL-TRIO.				apoptosis|induction of apoptosis|negative regulation of cell proliferation|regulation of growth rate	cytosol|nucleus	identical protein binding				0	Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GGGGAGCTGGCCCAACTCATA	0.453		NaN											1	0	7.04047e-22	0.023175	7.72297e-22	37	40									
FLG	2312	broad.mit.edu	37	1	152280711	152280711	+	Silent	SNP	G	G	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr1:152280711G>T	uc001ezu.1	-	3	6687	c.6651C>A	c.(6649-6651)GCC>GCA	p.A2217A		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2217	Ser-rich.|Filaggrin 13.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TAGAGCTGTCGGCCCAAGAGG	0.552		NaN							Ichthyosis				1	0	4.53876e-58	0.048971	5.30344e-58	206	656									
ADAM15	8751	broad.mit.edu	37	1	155030474	155030474	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr1:155030474G>A	uc001fgr.1	+	14	1665	c.1564G>A	c.(1564-1566)GGG>AGG	p.G522R	ADAM15_uc001fgq.1_Missense_Mutation_p.G207R|ADAM15_uc010pet.1_Missense_Mutation_p.G506R|ADAM15_uc010peu.1_Missense_Mutation_p.G539R|ADAM15_uc001fgt.1_Missense_Mutation_p.G522R|ADAM15_uc010pev.1_Missense_Mutation_p.G532R|ADAM15_uc001fgs.1_Missense_Mutation_p.G522R|ADAM15_uc001fgu.1_Missense_Mutation_p.G522R|ADAM15_uc001fgw.1_Missense_Mutation_p.G522R|ADAM15_uc001fgv.1_Missense_Mutation_p.G522R|ADAM15_uc001fgx.1_Missense_Mutation_p.G522R|ADAM15_uc001fgz.1_RNA|ADAM15_uc001fgy.1_RNA|ADAM15_uc001fha.1_RNA|ADAM15_uc001fhb.1_5'Flank	NM_207197	NP_997080	Q13444	ADA15_HUMAN	a disintegrin and metalloproteinase domain 15	522	Extracellular (Potential).|Cys-rich.				angiogenesis|cell-matrix adhesion|collagen catabolic process|proteolysis	acrosomal vesicle|adherens junction|endomembrane system|flagellum|integral to membrane	metalloendopeptidase activity|SH3 domain binding|zinc ion binding			central_nervous_system(3)|skin(2)|ovary(1)	6	all_epithelial(22;1.43e-30)|all_lung(78;6.64e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		BRCA - Breast invasive adenocarcinoma(34;0.000434)			GTGCATGCACGGGCGTTGTGC	0.632		NaN											0	0	0	0.027894	0	39	108									
F5	2153	broad.mit.edu	37	1	169511786	169511786	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr1:169511786G>A	uc001ggg.1	-	13	2687	c.2542C>T	c.(2542-2544)CGT>TGT	p.R848C		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	848	B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	GAAAGTAGACGTATCCCTGTG	0.458		NaN											0	0	0	0.048971	0	97	233									
HMCN1	83872	broad.mit.edu	37	1	186014962	186014962	+	Silent	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr1:186014962C>T	uc001grq.1	+	41	6676	c.6447C>T	c.(6445-6447)GGC>GGT	p.G2149G		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	2149	Ig-like C2-type 19.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						AGAAACCAGGCCTCAGTATAT	0.378		NaN											0	0	0	0.021523	0	25	58									
HMCN1	83872	broad.mit.edu	37	1	186158668	186158668	+	Silent	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr1:186158668C>T	uc001grq.1	+	107	16795	c.16566C>T	c.(16564-16566)CCC>CCT	p.P5522P	HMCN1_uc001grs.1_Silent_p.P974P	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	5522					response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						ACTGTCCACCCAATGATTTGG	0.438		NaN											0	0	0	0.048971	0	47	61									
RGS13	6003	broad.mit.edu	37	1	192628536	192628536	+	Silent	SNP	T	T	C			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr1:192628536T>C	uc001gsj.2	+	7	644	c.363T>C	c.(361-363)TTT>TTC	p.F121F	RGS13_uc001gsk.2_Silent_p.F121F	NM_002927	NP_002918	O14921	RGS13_HUMAN	regulator of G-protein signalling 13	121	RGS.					plasma membrane	GTPase activator activity|signal transducer activity				0						AAACATGTTTTGAAGAAGCTC	0.353		NaN											0	0	0	0.048971	0	45	25									
ZBTB41	360023	broad.mit.edu	37	1	197128821	197128821	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr1:197128821G>T	uc001gtx.1	-	10	2467	c.2398C>A	c.(2398-2400)CAG>AAG	p.Q800K	ZBTB41_uc009wyz.1_RNA	NM_194314	NP_919290	Q5SVQ8	ZBT41_HUMAN	zinc finger and BTB domain containing 41	800					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						GATACATTCTGTAACATCGTC	0.443		NaN											1	0	5.57489e-27	0.048971	6.2754e-27	56	125									
USH2A	7399	broad.mit.edu	37	1	216498861	216498861	+	Missense_Mutation	SNP	C	C	T	rs3820464		TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr1:216498861C>T	uc001hku.1	-	6	1316	c.929G>A	c.(928-930)CGG>CAG	p.R310Q	USH2A_uc001hkv.2_Missense_Mutation_p.R310Q	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	310	Laminin N-terminal.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		AGGGTGGACCCGCGGGTGGCT	0.532		NaN								HNSCC(13;0.011)			0	0	0	0.048971	0	93	60									
C1orf95	375057	broad.mit.edu	37	1	226784667	226784667	+	Missense_Mutation	SNP	A	A	G			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr1:226784667A>G	uc010pvn.1	+	2	472	c.367A>G	c.(367-369)ATG>GTG	p.M123V		NM_001003665	NP_001003665	Q69YW2	CA095_HUMAN	hypothetical protein LOC375057	123						integral to membrane				ovary(1)	1	Breast(184;0.133)	Prostate(94;0.0885)		GBM - Glioblastoma multiforme(131;0.113)		GGGCATGGACATGGTCATCCT	0.592		NaN											0	0	0	0.013537	0	13	200									
RYR2	6262	broad.mit.edu	37	1	237730002	237730002	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr1:237730002G>A	uc001hyl.1	+	28	3470	c.3350G>A	c.(3349-3351)TGG>TAG	p.W1117*		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	1117	Cytoplasmic (By similarity).|4 X approximate repeats.|B30.2/SPRY 2.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AGGGTTGGTTGGAGTCGTCCT	0.532		NaN											0	0	0	0.048971	0	114	325									
OR2W3	343171	broad.mit.edu	37	1	248059029	248059029	+	Silent	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr1:248059029G>A	uc001idp.1	+	3	410	c.141G>A	c.(139-141)CTG>CTA	p.L47L	OR2W3_uc010pzb.1_Silent_p.L47L	NM_001001957	NP_001001957	Q7Z3T1	OR2W3_HUMAN	olfactory receptor, family 2, subfamily W,	47	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|breast(1)|pancreas(1)	3	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0319)			CCATCATCCTGGTGTCCCGGC	0.592		NaN											0	0	0	0.028581	0	15	343									
OR2L8	391190	broad.mit.edu	37	1	248113003	248113003	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr1:248113003C>T	uc001idt.1	+	1	844	c.844C>T	c.(844-846)CCA>TCA	p.P282S	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	282	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			CATCCTCACCCCAATGCTCAA	0.483		NaN											0	0	0	0.019004	0	32	108									
IDI2	91734	broad.mit.edu	37	10	1066766	1066766	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr10:1066766C>T	uc001ifv.1	-	4	372	c.307G>A	c.(307-309)GGA>AGA	p.G103R	C10orf110_uc010qaf.1_5'Flank|C10orf110_uc001ifx.3_5'Flank|C10orf110_uc001ifw.3_5'Flank|C10orf110_uc001ify.3_5'Flank	NM_033261	NP_150286	Q9BXS1	IDI2_HUMAN	isopentenyl-diphosphate delta isomerase 2	103	Nudix hydrolase.				carotenoid biosynthetic process|cholesterol biosynthetic process	cytosol|peroxisome	hydrolase activity|isopentenyl-diphosphate delta-isomerase activity|metal ion binding				0		Colorectal(49;0.235)	OV - Ovarian serous cystadenocarcinoma(33;0.143)	Epithelial(11;0.067)|OV - Ovarian serous cystadenocarcinoma(14;0.169)|all cancers(11;0.192)		CTCCTCACTCCGATGGCATCC	0.542		NaN											0	0	0	0.014323	0	22	29									
CUBN	8029	broad.mit.edu	37	10	16994309	16994309	+	Silent	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr10:16994309C>T	uc001ioo.2	-	33	4987	c.4935G>A	c.(4933-4935)CAG>CAA	p.Q1645Q		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1645	CUB 11.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AGCTGCAGTTCTGATTGTTTG	0.478		NaN											0	0	0	0.048971	0	49	65									
MPP7	143098	broad.mit.edu	37	10	28358781	28358782	+	Splice_Site	DNP	CC	CC	AA			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr10:28358781_28358782CC>AA	uc001iua.1	-	15	1528	c.1124_splice	c.e15-1	p.G375_splice	MPP7_uc009xkz.1_Splice_Site|MPP7_uc001iub.1_Splice_Site_p.G375_splice|MPP7_uc009xla.2_Splice_Site_p.G375_splice|MPP7_uc010qdv.1_Splice_Site	NM_173496	NP_775767	Q5T2T1	MPP7_HUMAN	palmitoylated membrane protein 7						establishment of cell polarity|positive regulation of protein complex assembly|protein localization to adherens junction|tight junction assembly	MPP7-DLG1-LIN7 complex|tight junction	protein complex scaffold|protein domain specific binding|protein heterodimerization activity|signaling adaptor activity			ovary(1)	1						TCCCACGGGACCTGAAAAACAG	0.46		NaN											0	0	0	0.004672	0	13	16									
ADAMTS14	140766	broad.mit.edu	37	10	72520532	72520532	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr10:72520532C>G	uc001jrh.2	+	22	3595	c.3595C>G	c.(3595-3597)CCT>GCT	p.P1199A	ADAMTS14_uc001jrg.2_Missense_Mutation_p.P1202A	NM_080722	NP_542453	Q8WXS8	ATS14_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1199	Pro-rich.				collagen catabolic process|proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(5)|upper_aerodigestive_tract(1)	6						TACGCCAGTCCCTGAGGACAA	0.647		NaN											0	0	0	0.059317	0	32	64									
DDIT4	54541	broad.mit.edu	37	10	74034625	74034625	+	Silent	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr10:74034625G>A	uc001jsx.1	+	3	580	c.378G>A	c.(376-378)CAG>CAA	p.Q126Q		NM_019058	NP_061931	Q9NX09	DDIT4_HUMAN	RTP801	126					apoptosis					pancreas(1)	1						TGGTAAGCCAGGTGGGCAAAG	0.692		NaN									OREG0020262	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.048971	0	67	107									
KNDC1	85442	broad.mit.edu	37	10	134981802	134981802	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr10:134981802G>C	uc001llz.1	+	3	347	c.346G>C	c.(346-348)GGG>CGG	p.G116R	KNDC1_uc001lma.1_Missense_Mutation_p.G51R	NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	116	KIND 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		CGACGTGACCGGGAACACCTT	0.562		NaN											0	0	0	0.048971	0	63	98									
DBX1	120237	broad.mit.edu	37	11	20180780	20180780	+	Silent	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr11:20180780G>A	uc001mpw.1	-	2	426	c.426C>T	c.(424-426)TTC>TTT	p.F142F		NM_001029865	NP_001025036	A6NMT0	DBX1_HUMAN	developing brain homeobox 1	142					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						AAGACCCTTCGAAGTAGGGAA	0.602		NaN											0	0	0	0.02938	0	7	128									
QSER1	79832	broad.mit.edu	37	11	32954330	32954330	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr11:32954330G>T	uc001mty.2	+	4	1406	c.1139G>T	c.(1138-1140)GGG>GTG	p.G380V	QSER1_uc001mtz.1_Intron|QSER1_uc001mua.2_5'Flank	NM_001076786	NP_001070254	Q2KHR3	QSER1_HUMAN	glutamine and serine rich 1	380	Ser-rich.									ovary(3)|central_nervous_system(2)|skin(1)	6	Breast(20;0.158)					ACTTTTTCTGGGTCATCTCAG	0.383		NaN											1	0	2.13384e-23	0.048971	2.35269e-23	46	69									
TTC17	55761	broad.mit.edu	37	11	43465060	43465060	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr11:43465060G>A	uc001mxi.2	+	17	2451	c.2437G>A	c.(2437-2439)GGT>AGT	p.G813S	TTC17_uc001mxh.2_Missense_Mutation_p.G870S|TTC17_uc010rfj.1_Missense_Mutation_p.G813S|TTC17_uc001mxj.2_Missense_Mutation_p.G640S	NM_018259	NP_060729	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	813							binding			ovary(5)	5						GCTGAAGAAAGGTCCCCAGGA	0.488		NaN											0	0	0	0.038147	0	8	97									
SSRP1	6749	broad.mit.edu	37	11	57100511	57100511	+	Silent	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr11:57100511G>A	uc001njt.2	-	5	726	c.459C>T	c.(457-459)AAC>AAT	p.N153N	SSRP1_uc010rjq.1_Silent_p.N153N	NM_003146	NP_003137	Q08945	SSRP1_HUMAN	structure specific recognition protein 1	153					DNA repair|DNA replication|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	chromosome|cytoplasm|nucleoplasm	DNA binding|protein binding			ovary(2)	2						CTGCGTCATCGTTTTGGTGGA	0.557		NaN											0	0	0	0.048971	0	76	98									
MAP3K11	4296	broad.mit.edu	37	11	65375774	65375774	+	Silent	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr11:65375774C>T	uc001oew.2	-	2	1378	c.885G>A	c.(883-885)AAG>AAA	p.K295K	MAP3K11_uc001oev.2_5'Flank|MAP3K11_uc010rol.1_Silent_p.K38K|MAP3K11_uc001oex.1_5'UTR	NM_002419	NP_002410	Q16584	M3K11_HUMAN	mitogen-activated protein kinase kinase kinase	295	Protein kinase.				activation of JUN kinase activity|cell proliferation|G1 phase of mitotic cell cycle|microtubule-based process|positive regulation of JNK cascade|protein autophosphorylation	centrosome|microtubule	ATP binding|JUN kinase kinase kinase activity|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity			breast(3)|lung(1)|central_nervous_system(1)|skin(1)	6						AGGTGGAGGCCTTGATAACCT	0.627		NaN											0	0	0	0.016522	0	22	63									
GRM5	2915	broad.mit.edu	37	11	88583193	88583193	+	Silent	SNP	G	G	A	rs145650472		TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr11:88583193G>A	uc001pcq.2	-	2	992	c.792C>T	c.(790-792)CTC>CTT	p.L264L	GRM5_uc009yvm.2_Silent_p.L264L	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	264	Extracellular (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	AGTGACTTGTGAGCTTCTTCA	0.547		NaN											0	0	0	0.041601	0	27	42									
CNTN5	53942	broad.mit.edu	37	11	99944885	99944886	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr11:99944885_99944886CC>AA	uc001pga.2	+	13	1778_1779	c.1439_1440CC>AA	c.(1438-1440)CCC>CAA	p.P480Q	CNTN5_uc009ywv.1_Missense_Mutation_p.P480Q|CNTN5_uc001pfz.2_Missense_Mutation_p.P480Q|CNTN5_uc001pgb.2_Missense_Mutation_p.P406Q	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	480	Ig-like C2-type 5.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		GCTTCAGCTCCCACTTTTGCAC	0.366		NaN											0	0	0	0.004672	0	11	8									
DYNC2H1	79659	broad.mit.edu	37	11	103124075	103124075	+	Silent	SNP	C	C	G			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr11:103124075C>G	uc001pho.2	+	66	10248	c.10104C>G	c.(10102-10104)CTC>CTG	p.L3368L	DYNC2H1_uc001phn.1_Silent_p.L3375L|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	3368	AAA 5 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		AATTCCGCCTCTTTTTGTCAA	0.373		NaN											0	0	0	0.050027	0	34	52									
DDI1	414301	broad.mit.edu	37	11	103908520	103908520	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr11:103908520C>A	uc001phr.2	+	1	1213	c.970C>A	c.(970-972)CAA>AAA	p.Q324K	PDGFD_uc001php.2_Intron|PDGFD_uc001phq.2_Intron	NM_001001711	NP_001001711	Q8WTU0	DDI1_HUMAN	DDI1, DNA-damage inducible 1, homolog 1	324					proteolysis		aspartic-type endopeptidase activity			large_intestine(3)|upper_aerodigestive_tract(1)|pancreas(1)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		ACTTGAGGATCAACCCATGGA	0.448		NaN											1	0	1.06522e-23	0.045515	1.18053e-23	46	83									
NCAM1	4684	broad.mit.edu	37	11	113145992	113145992	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr11:113145992G>A	uc001pns.2	+	6	748	c.716G>A	c.(715-717)AGG>AAG	p.R239K	uc010rwu.1_5'Flank|NCAM1_uc001pnt.2_Silent_p.K55K			P13591	NCAM1_HUMAN	SubName: Full=cDNA FLJ52974, highly similar to Neural cell adhesion molecule 1, 140 kDa isoform;	Error:Variant_position_missing_in_P13591_after_alignment					axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				ovary(1)	1		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		TCTGCAGGAAGGGCCCCGTAG	0.592		NaN											0	0	0	0.038395	0	18	23									
MLL	4297	broad.mit.edu	37	11	118348798	118348798	+	Nonsense_Mutation	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr11:118348798C>T	uc001pta.2	+	5	3474	c.3451C>T	c.(3451-3453)CGA>TGA	p.R1151*	MLL_uc001ptb.2_Nonsense_Mutation_p.R1151*	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1151	CXXC-type.			R->A: Impairs DNA-binding.	apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		GAAAGGACGTCGATCGAGGCG	0.512		NaN	T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								0	0	0	0.021523	0	23	249									
PANX3	116337	broad.mit.edu	37	11	124489476	124489476	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr11:124489476C>T	uc001qah.2	+	4	824	c.824C>T	c.(823-825)TCC>TTC	p.S275F		NM_052959	NP_443191	Q96QZ0	PANX3_HUMAN	pannexin 3	275	Helical; (Potential).				protein hexamerization	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity				0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0219)		GTTAGCCTCTCCAGTGTAGCA	0.458		NaN											0	0	0	0.062417	0	22	47									
TULP3	7289	broad.mit.edu	37	12	3040245	3040245	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr12:3040245G>C	uc010seh.1	+	6	616	c.535G>C	c.(535-537)GAT>CAT	p.D179H	TULP3_uc010sef.1_RNA|TULP3_uc009zec.1_5'UTR|TULP3_uc010seg.1_RNA|TULP3_uc001qlj.2_Missense_Mutation_p.D179H|TULP3_uc010sei.1_Missense_Mutation_p.D36H	NM_003324	NP_003315	O75386	TULP3_HUMAN	tubby like protein 3 isoform 1	179				TSGSATAAQPADNL -> IPVLLLPPNQLITF (in Ref. 1).	G-protein coupled receptor protein signaling pathway|regulation of transcription, DNA-dependent	cytoplasm|extracellular region|nucleus|plasma membrane	phosphatidylinositol-4,5-bisphosphate binding				0			OV - Ovarian serous cystadenocarcinoma(31;0.000818)			CCAACCAGCTGATAACCTCCT	0.507		NaN											0	0	0	0.048971	0	48	80									
KCNA5	3741	broad.mit.edu	37	12	5154246	5154246	+	Silent	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr12:5154246G>A	uc001qni.2	+	1	1162	c.933G>A	c.(931-933)ACG>ACA	p.T311T		NM_002234	NP_002225	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related	311						Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(2)|breast(2)	4						CTGGCCCTACGGTGGCACCGC	0.711		NaN											0	0	0	0.048971	0	53	91									
LTBR	4055	broad.mit.edu	37	12	6499851	6499851	+	Silent	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr12:6499851C>T	uc001qny.1	+	10	1224	c.1056C>T	c.(1054-1056)GGC>GGT	p.G352G	LTBR_uc010sfc.1_Silent_p.G333G|LTBR_uc001qnz.1_Silent_p.G347G	NM_002342	NP_002333	P36941	TNR3_HUMAN	lymphotoxin beta receptor precursor	352	Cytoplasmic (Potential).				apoptosis|cellular response to mechanical stimulus|interspecies interaction between organisms|positive regulation of I-kappaB kinase/NF-kappaB cascade	integral to membrane	protein binding|receptor activity			lung(2)	2						ATGTCACCGGCGGGTCTATGA	0.562		NaN											0	0	0	0.048971	0	96	98									
AICDA	57379	broad.mit.edu	37	12	8758001	8758001	+	Silent	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr12:8758001G>A	uc001qur.2	-	3	316	c.237C>T	c.(235-237)ACC>ACT	p.T79T	AICDA_uc001qup.1_Silent_p.T74T|AICDA_uc001quq.1_Silent_p.T74T|AICDA_uc009zgd.1_Intron	NM_020661	NP_065712	Q9GZX7	AICDA_HUMAN	activation-induced cytidine deaminase	79					B cell differentiation|DNA demethylation|mRNA processing|negative regulation of methylation-dependent chromatin silencing	cytoplasm	cytidine deaminase activity|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung SC(5;0.184)					AGGTGAACCAGGTGACGCGGT	0.627		NaN							Immune_Deficiency_with_Hyper-IgM				0	0	0	0.01892	0	25	66									
C12orf36	283422	broad.mit.edu	37	12	13526293	13526293	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr12:13526293G>A	uc001rbs.1	-	3	480	c.262C>T	c.(262-264)CCT>TCT	p.P88S		NM_182558	NP_872364			hypothetical protein LOC283422												0				BRCA - Breast invasive adenocarcinoma(232;0.198)		CCCAGGGGAGGAGCTCGTGCA	0.463		NaN											0	0	0	0.048971	0	63	81									
SLCO1C1	53919	broad.mit.edu	37	12	20874968	20874968	+	Missense_Mutation	SNP	A	A	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr12:20874968A>T	uc001rej.3	+	9	1361	c.1006A>T	c.(1006-1008)ATG>TTG	p.M336L	SLCO1C1_uc010sii.1_Missense_Mutation_p.M336L|SLCO1C1_uc010sij.1_Missense_Mutation_p.M287L|SLCO1C1_uc009zip.2_Missense_Mutation_p.M170L|SLCO1C1_uc001rei.2_Missense_Mutation_p.M336L|SLCO1C1_uc010sik.1_Missense_Mutation_p.M218L	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	336	Cytoplasmic (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					TGCAAAAATAATGGAAATGGC	0.264		NaN											0	0	0	0.024245	0	14	27									
KRT75	9119	broad.mit.edu	37	12	52827910	52827910	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr12:52827910C>T	uc001saj.2	-	1	201	c.179G>A	c.(178-180)CGC>CAC	p.R60H		NM_004693	NP_004684	O95678	K2C75_HUMAN	keratin 75	60	Gly-rich.|Head.					keratin filament	structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(357;0.192)		GTAGAGGCTGCGGCTTCCAAA	0.652		NaN											0	0	0	0.058154	0	10	114									
KRT6C	286887	broad.mit.edu	37	12	52862934	52862934	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr12:52862934C>T	uc001sal.3	-	9	1655	c.1607G>A	c.(1606-1608)GGG>GAG	p.G536E		NM_173086	NP_775109	P48668	K2C6C_HUMAN	keratin 6C	536	Tail.				cytoskeleton organization	keratin filament	structural molecule activity			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.0828)		GAGGCCACCCCCAATGGCTCT	0.592		NaN											0	0	0	0.030593	0	25	72									
SPIC	121599	broad.mit.edu	37	12	101880371	101880371	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr12:101880371C>T	uc001tid.2	+	6	728	c.569C>T	c.(568-570)ACT>ATT	p.T190I	SPIC_uc009zua.2_Missense_Mutation_p.T65I|SPIC_uc010svp.1_Missense_Mutation_p.T189I	NM_152323	NP_689536	Q8N5J4	SPIC_HUMAN	Spi-C transcription factor (Spi-1/PU.1 related)	190	ETS.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						AGGAAGCTGACTTACCAGTTC	0.443		NaN											0	0	0	0.016723	0	12	116									
STAB2	55576	broad.mit.edu	37	12	104067714	104067714	+	Missense_Mutation	SNP	A	A	G			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr12:104067714A>G	uc001tjw.2	+	23	2587	c.2401A>G	c.(2401-2403)AAC>GAC	p.N801D		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	801	Extracellular (Potential).				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						AACATGCAATAACAGGATAGA	0.592		NaN											0	0	0	0.045515	0	47	50									
STAB2	55576	broad.mit.edu	37	12	104092983	104092983	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr12:104092983G>A	uc001tjw.2	+	34	3878	c.3692G>A	c.(3691-3693)AGC>AAC	p.S1231N		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	1231	Extracellular (Potential).|FAS1 4.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						TATTTCCTTAGCTTCTTTCTC	0.473		NaN											0	0	0	0.0333	0	16	26									
MLXIP	22877	broad.mit.edu	37	12	122626341	122626341	+	Silent	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr12:122626341G>A	uc001ubq.2	+	17	2742	c.2742G>A	c.(2740-2742)AAG>AAA	p.K914K	MLXIP_uc001ubt.2_Silent_p.K521K	NM_014938	NP_055753	Q9HAP2	MLXIP_HUMAN	MLX interacting protein	914					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial outer membrane|nucleus	DNA binding			ovary(2)	2	all_neural(191;0.0837)|Medulloblastoma(191;0.163)	Lung NSC(355;0.0659)		OV - Ovarian serous cystadenocarcinoma(86;0.000599)|Epithelial(86;0.00102)|BRCA - Breast invasive adenocarcinoma(302;0.233)		GGATTGGCAAGAGATTGGGAG	0.622		NaN											0	0	0	0.036044	0	40	73									
TMEM132B	114795	broad.mit.edu	37	12	126138270	126138270	+	Nonsense_Mutation	SNP	G	G	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr12:126138270G>T	uc001uhe.1	+	9	2259	c.2251G>T	c.(2251-2253)GAG>TAG	p.E751*	TMEM132B_uc001uhf.1_Nonsense_Mutation_p.E263*	NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	751	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		TGTGGTTGCAGAGGGTGAAGG	0.433		NaN											1	0	1.30916e-28	0.048971	1.48142e-28	50	89									
PCDH20	64881	broad.mit.edu	37	13	61987073	61987073	+	Nonsense_Mutation	SNP	C	C	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr13:61987073C>A	uc001vid.3	-	2	1523	c.1159G>T	c.(1159-1161)GGA>TGA	p.G387*	PCDH20_uc010thj.1_Nonsense_Mutation_p.G387*	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	360	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		ACACTTCCTCCAATCTTACTG	0.398		NaN											1	0	1.61742e-36	0.048971	1.86959e-36	58	96									
KLF5	688	broad.mit.edu	37	13	73636642	73636642	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr13:73636642C>A	uc001vje.2	+	2	1229	c.905C>A	c.(904-906)CCG>CAG	p.P302Q	KLF5_uc001vjd.2_Missense_Mutation_p.P211Q	NM_001730	NP_001721	Q13887	KLF5_HUMAN	Kruppel-like factor 5	302					transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|pancreas(1)	3		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		TACTTTCCCCCGTCACCACCA	0.502		NaN											1	0	2.89935e-36	0.048971	3.33348e-36	67	63									
OR4N2	390429	broad.mit.edu	37	14	20296395	20296395	+	Missense_Mutation	SNP	G	G	T	rs148867085		TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr14:20296395G>T	uc010tkv.1	+	1	788	c.788G>T	c.(787-789)AGG>ATG	p.R263M		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	263	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CGCCCCTTCAGGGCTTTCCCA	0.458		NaN											1	0	4.6707e-30	0.048971	5.31323e-30	52	73									
PRKD1	5587	broad.mit.edu	37	14	30100021	30100021	+	Silent	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr14:30100021C>T	uc001wqh.2	-	10	1780	c.1599G>A	c.(1597-1599)GAG>GAA	p.E533E		NM_002742	NP_002733	Q15139	KPCD1_HUMAN	protein kinase D1	533	PH.				cell proliferation|intracellular signal transduction|sphingolipid metabolic process	cytosol|integral to plasma membrane	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(3)|large_intestine(2)|ovary(2)|skin(1)	8	Hepatocellular(127;0.0604)		LUAD - Lung adenocarcinoma(48;0.00527)|Lung(238;0.0252)	GBM - Glioblastoma multiforme(265;0.00888)		GGATGGCTATCTCCCACATCC	0.522		NaN											0	0	0	0.047766	0	9	135									
FANCM	57697	broad.mit.edu	37	14	45605269	45605269	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr14:45605269G>A	uc001wwd.3	+	1	134	c.35G>A	c.(34-36)TGG>TAG	p.W12*	FANCM_uc001wwc.2_Nonsense_Mutation_p.W12*|FANCM_uc010anf.2_Nonsense_Mutation_p.W12*|FKBP3_uc010tqf.1_5'Flank	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	12					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						TTTCAGACGTGGGGCTCAAGT	0.587		NaN						Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.042209	0	47	81									
C14orf104	55172	broad.mit.edu	37	14	50100212	50100212	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr14:50100212C>A	uc001wws.3	-	1	1737	c.1656G>T	c.(1654-1656)TTG>TTT	p.L552F	SDCCAG1_uc010anj.1_Intron|C14orf104_uc001wwt.3_Missense_Mutation_p.L552F	NM_018139	NP_060609	Q9NVR5	KTU_HUMAN	kintoun isoform 1	552					axonemal dynein complex assembly|ciliary cell motility|flagellar cell motility	cytoplasm					0	all_epithelial(31;0.0021)|Breast(41;0.0124)					AGAGGGGATTCAAATCTCCTT	0.443		NaN							Kartagener_syndrome				1	0	3.32936e-07	0.038395	3.45803e-07	17	48									
NID2	22795	broad.mit.edu	37	14	52474664	52474664	+	Nonsense_Mutation	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr14:52474664C>T	uc001wzo.2	-	19	3978	c.3744G>A	c.(3742-3744)TGG>TGA	p.W1248*	NID2_uc010tqs.1_Nonsense_Mutation_p.W1200*|NID2_uc010tqt.1_Nonsense_Mutation_p.W1248*	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	1248	LDL-receptor class B 3.					basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					CTTCTCTATTCCAGTCTGTCC	0.239		NaN											0	0	0	0.014758	0	5	54									
SLC35F4	341880	broad.mit.edu	37	14	58038711	58038711	+	Silent	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr14:58038711G>A	uc001xdb.1	-	5	942	c.942C>T	c.(940-942)ACC>ACT	p.T314T	SLC35F4_uc010aoz.1_RNA|SLC35F4_uc010apa.1_Silent_p.T155T	NM_001080455	NP_001073924			solute carrier family 35, member F4											ovary(2)	2						TGACAATGCCGGTAATTGCCA	0.433		NaN											0	0	0	0.008291	0	9	12									
SLC10A1	6554	broad.mit.edu	37	14	70252943	70252943	+	Silent	SNP	A	A	G			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr14:70252943A>G	uc001xlr.2	-	2	572	c.438T>C	c.(436-438)TAT>TAC	p.Y146Y		NM_003049	NP_003040	Q14973	NTCP_HUMAN	solute carrier family 10, member 1	146					bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			ovary(1)	1				all cancers(60;0.00228)|BRCA - Breast invasive adenocarcinoma(234;0.0137)|OV - Ovarian serous cystadenocarcinoma(108;0.0226)		GGTCCCCATCATAGATCCCCC	0.522		NaN											0	0	0	0.048971	0	56	72									
KIAA1409	57578	broad.mit.edu	37	14	94088092	94088092	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr14:94088092G>A	uc001ybv.1	+	28	4131	c.4048G>A	c.(4048-4050)GGG>AGG	p.G1350R	KIAA1409_uc001ybs.1_Missense_Mutation_p.G1328R	NM_020818	NP_065869	Q9P2D8	UNC79_HUMAN	hypothetical protein LOC57578	1505						integral to membrane				ovary(10)|skin(4)|large_intestine(3)	17		all_cancers(154;0.0354)|all_epithelial(191;0.216)		Epithelial(152;0.188)		TCTTGATATAGGGAATGCAGA	0.438		NaN											0	0	0	0.059317	0	33	64									
ZNF839	55778	broad.mit.edu	37	14	102808061	102808061	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr14:102808061G>A	uc001ylo.2	+	8	2331	c.1981G>A	c.(1981-1983)GAC>AAC	p.D661N	ZNF839_uc010awk.1_Missense_Mutation_p.D777N|ZNF839_uc001ylp.2_RNA|ZNF839_uc001ylq.1_Intron|ZNF839_uc001ylr.2_Missense_Mutation_p.D586N|ZNF839_uc001yls.2_Missense_Mutation_p.D278N|ZNF839_uc001ylt.2_Missense_Mutation_p.D251N	NM_018335	NP_060805	A8K0R7	ZN839_HUMAN	zinc finger protein 839	661						intracellular	zinc ion binding			ovary(1)|central_nervous_system(1)	2						CAAGGTTTGTGACTTCCACCT	0.622		NaN											0	0	0	0.047766	0	9	120									
DUOX2	50506	broad.mit.edu	37	15	45403752	45403752	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr15:45403752C>T	uc010bea.2	-	6	748	c.545G>A	c.(544-546)AGC>AAC	p.S182N	DUOX2_uc001zun.2_Missense_Mutation_p.S182N|DUOXA2_uc001zuo.2_5'Flank|DUOXA2_uc010beb.2_5'Flank	NM_014080	NP_054799	Q9NRD8	DUOX2_HUMAN	dual oxidase 2 precursor	182	Extracellular (Potential).|Peroxidase-like; mediates peroxidase activity (By similarity).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|response to virus	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|peroxidase activity			ovary(2)|skin(2)|pancreas(1)	5		all_cancers(109;3.79e-11)|all_epithelial(112;2.92e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.05e-18)|GBM - Glioblastoma multiforme(94;4.23e-07)|COAD - Colon adenocarcinoma(120;0.0668)|Colorectal(133;0.068)		ATAGATGGCGCTGCCGTCCAG	0.766		NaN											0	0	0	0.009096	0	4	9									
DAPK2	23604	broad.mit.edu	37	15	64275760	64275760	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr15:64275760G>T	uc002amr.2	-	3	317	c.286C>A	c.(286-288)CGC>AGC	p.R96S	DAPK2_uc010uim.1_Intron|DAPK2_uc010bgu.1_Missense_Mutation_p.R86S	NM_014326	NP_055141	Q9UIK4	DAPK2_HUMAN	death-associated kinase 2	96	Protein kinase.				apoptosis|induction of apoptosis|intracellular protein kinase cascade	cytoplasm	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity|identical protein binding			stomach(1)|central_nervous_system(1)	2				LUAD - Lung adenocarcinoma(2;0.215)		ACGTCGGTGCGGTTCTCATAG	0.652		NaN											1	0	1.52319e-26	0.033182	1.69681e-26	37	66									
CELF6	60677	broad.mit.edu	37	15	72608188	72608188	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr15:72608188C>T	uc002auh.2	-	2	653	c.343G>A	c.(343-345)GGG>AGG	p.G115R	uc002aug.2_Intron|CELF6_uc002auk.3_RNA|CELF6_uc010biv.1_RNA|CELF6_uc010ukm.1_Missense_Mutation_p.G115R|CELF6_uc002aui.2_Missense_Mutation_p.R237K|CELF6_uc002auj.2_5'UTR	NM_052840	NP_443072	Q96J87	CELF6_HUMAN	bruno-like 6, RNA binding protein	115	RRM 1.				mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	nucleotide binding|RNA binding			large_intestine(1)|central_nervous_system(1)|skin(1)	3						GGACTTACCCCTGGCAGGGTC	0.642		NaN											0	0	0	0.004672	0	3	9									
OR4F6	390648	broad.mit.edu	37	15	102346616	102346616	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr15:102346616G>C	uc010utr.1	+	1	694	c.694G>C	c.(694-696)GGT>CGT	p.G232R		NM_001005326	NP_001005326	Q8NGB9	OR4F6_HUMAN	olfactory receptor, family 4, subfamily F,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.00039)|Lung(145;0.17)|LUSC - Lung squamous cell carcinoma(107;0.187)			ATCTTCAGGTGGTATATTCAA	0.353		NaN											0	0	0	0.048971	0	54	115									
MSLN	10232	broad.mit.edu	37	16	813678	813678	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr16:813678C>G	uc002cjw.1	+	4	217	c.166C>G	c.(166-168)CCT>GCT	p.P56A	MSLN_uc002cjt.1_Missense_Mutation_p.P56A|MSLN_uc002cju.1_Missense_Mutation_p.P56A|MSLN_uc010brd.1_Missense_Mutation_p.P55A|MSLN_uc002cjv.1_Missense_Mutation_p.P56A|MSLN_uc002cjx.1_Missense_Mutation_p.P56A|MSLN_uc002cjy.1_5'Flank	NM_013404	NP_037536	Q13421	MSLN_HUMAN	mesothelin isoform 2 preproprotein	56				ANPP -> TTPH (in Ref. 2; AAC50348).	cell adhesion	anchored to membrane|extracellular region|Golgi apparatus|plasma membrane				pancreas(1)	1		Hepatocellular(780;0.00335)				GGCCAACCCACCTAACATTTC	0.662		NaN											0	0	0	0.020292	0	14	12									
RNPS1	10921	broad.mit.edu	37	16	2305696	2305696	+	Silent	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr16:2305696G>A	uc002cpt.2	-	7	1254	c.708C>T	c.(706-708)ACC>ACT	p.T236T	RNPS1_uc002cpu.2_Silent_p.T236T|RNPS1_uc002cpv.2_Silent_p.T59T|RNPS1_uc002cpw.2_Silent_p.T236T|RNPS1_uc002cpx.2_Silent_p.T213T|RNPS1_uc010uwa.1_RNA	NM_080594	NP_542161	Q15287	RNPS1_HUMAN	RNA-binding protein S1, serine-rich domain	236	Necessary for interaction with PNN and exon-skipping.|RRM.				mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|termination of RNA polymerase II transcription	cytosol|nuclear speck	mRNA 3'-UTR binding|nucleotide binding|protein binding			ovary(1)	1						CCAGCACGGCGGTGGCAGTGA	0.562		NaN											0	0	0	0.043863	0	20	36									
SMG1	23049	broad.mit.edu	37	16	18849753	18849753	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr16:18849753G>A	uc002dfm.2	-	44	7483	c.7120C>T	c.(7120-7122)CGA>TGA	p.R2374*	SMG1_uc010bwb.2_Nonsense_Mutation_p.R2234*|SMG1_uc010bwa.2_Nonsense_Mutation_p.R1105*	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	2374	PI3K/PI4K.				DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						TGTGTCATTCGAAAAGGTACT	0.373		NaN											0	0	0	0.02938	0	7	76									
NFATC2IP	84901	broad.mit.edu	37	16	28965901	28965901	+	Missense_Mutation	SNP	A	A	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr16:28965901A>T	uc002dru.2	+	3	491	c.476A>T	c.(475-477)GAT>GTT	p.D159V	uc010vct.1_Intron|NFATC2IP_uc002drt.2_Intron	NM_032815	NP_116204	Q8NCF5	NF2IP_HUMAN	nuclear factor of activated T-cells,	159						cytoplasm|nucleus				ovary(1)	1						GAGCTGGCAGATTCGAGTGGT	0.522		NaN											0	0	0	0.048971	0	89	149									
IRX3	79191	broad.mit.edu	37	16	54319028	54319028	+	Silent	SNP	A	A	G			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr16:54319028A>G	uc002eht.1	-	2	1181	c.765T>C	c.(763-765)GAT>GAC	p.D255D		NM_024336	NP_077312	P78415	IRX3_HUMAN	iroquois homeobox 3	255	Asp/Glu-rich (acidic).				multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						AGTTCTCCAAATCGATctcct	0.403		NaN											0	0	0	0.0333	0	18	23									
MMP2	4313	broad.mit.edu	37	16	55525777	55525777	+	Silent	SNP	A	A	G			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr16:55525777A>G	uc002ehz.3	+	8	1556	c.1245A>G	c.(1243-1245)CAA>CAG	p.Q415Q	MMP2_uc010vhd.1_Silent_p.Q339Q|MMP2_uc010ccc.2_Silent_p.Q365Q|MMP2_uc002eia.3_5'Flank	NM_004530	NP_004521	P08253	MMP2_HUMAN	matrix metalloproteinase 2 isoform a	415	Required for inhibitor TIMP2 binding.|Collagenase-like 2.				angiogenesis|collagen catabolic process|proteolysis	extracellular space|membrane|nucleus|proteinaceous extracellular matrix	metalloendopeptidase activity|protein binding|zinc ion binding			large_intestine(3)|ovary(3)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	11		Renal(780;0.00183)|Breast(268;0.00354)|Hepatocellular(780;0.00826)|all_neural(199;0.0189)		UCEC - Uterine corpus endometrioid carcinoma (183;0.0185)|all cancers(182;7.16e-45)|Epithelial(162;5.26e-37)|GBM - Glioblastoma multiforme(240;9e-08)|Kidney(780;0.00227)|BRCA - Breast invasive adenocarcinoma(181;0.00786)	Marimastat(DB00786)|Sulindac(DB00605)	AGCACTCCCAAGACCCTGGGG	0.577		NaN											0	0	0	0.025465	0	41	75									
KARS	3735	broad.mit.edu	37	16	75665679	75665679	+	Silent	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr16:75665679C>T	uc002feq.2	-	8	1038	c.990G>A	c.(988-990)ACG>ACA	p.T330T	KARS_uc002fer.2_Silent_p.T358T|KARS_uc002fes.2_Silent_p.T174T	NM_005548	NP_005539	Q15046	SYK_HUMAN	lysyl-tRNA synthetase isoform 2	330					interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding			ovary(2)	2					L-Lysine(DB00123)	CAGGATTGTGCGTCAAATCAA	0.493		NaN											0	0	0	0.048971	0	87	135									
OR1A2	26189	broad.mit.edu	37	17	3101305	3101305	+	Missense_Mutation	SNP	A	A	G			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr17:3101305A>G	uc002fvd.1	+	1	493	c.493A>G	c.(493-495)AGT>GGT	p.S165G		NM_012352	NP_036484	Q9Y585	OR1A2_HUMAN	olfactory receptor, family 1, subfamily A,	165	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						GCTCACAGCTAGTTTGTCCTT	0.458		NaN											0	0	0	0.048971	0	49	73									
GPR179	440435	broad.mit.edu	37	17	36486976	36486976	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr17:36486976C>G	uc002hpz.2	-	11	2497	c.2476G>C	c.(2476-2478)GGA>CGA	p.G826R		NM_001004334	NP_001004334	Q6PRD1	GP179_HUMAN	GPR158-like 1 precursor	826	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3	Breast(7;2.97e-12)	Breast(25;0.0101)|Ovarian(249;0.15)				AGCCTCTCTCCCACCGTCAGG	0.667		NaN											0	0	0	0.008291	0	10	17									
C17orf65	339201	broad.mit.edu	37	17	42254079	42254079	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr17:42254079C>T	uc002ifn.2	-	4	1518	c.542G>A	c.(541-543)AGG>AAG	p.R181K	ASB16_uc002ifl.1_Intron|ASB16_uc002ifm.1_Intron	NM_178542	NP_848637	Q495Z4	CQ065_HUMAN	hypothetical protein LOC339201	181											0		Breast(137;0.00765)|Prostate(33;0.0313)		BRCA - Breast invasive adenocarcinoma(366;0.114)		CAGGATTTTCCTCAGGACCTT	0.597		NaN											0	0	0	0.048971	0	71	142									
MYST2	11143	broad.mit.edu	37	17	47874209	47874209	+	Silent	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr17:47874209G>A	uc002ipm.2	+	3	387	c.261G>A	c.(259-261)GTG>GTA	p.V87V	MYST2_uc002ipl.1_Silent_p.V87V|MYST2_uc010wma.1_Intron|MYST2_uc010wmb.1_Silent_p.V87V|MYST2_uc010wmc.1_Intron|MYST2_uc010wmd.1_5'UTR|MYST2_uc010wme.1_5'UTR	NM_007067	NP_008998	O95251	MYST2_HUMAN	MYST histone acetyltransferase 2	87					DNA replication|histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	histone acetyltransferase activity|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|lung(1)|skin(1)	3						CTACCCCAGTGACACCGAAAA	0.488		NaN											0	0	0	0.030593	0	23	263									
AKAP1	8165	broad.mit.edu	37	17	55183204	55183204	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr17:55183204G>A	uc002iux.2	+	2	610	c.379G>A	c.(379-381)GAC>AAC	p.D127N	AKAP1_uc010wnl.1_Missense_Mutation_p.D127N|AKAP1_uc002iuy.2_RNA|AKAP1_uc010dcm.2_Missense_Mutation_p.D127N	NM_003488	NP_003479	Q92667	AKAP1_HUMAN	A-kinase anchor protein 1 precursor	127					blood coagulation	cytosol|integral to membrane|mitochondrial outer membrane	protein binding|RNA binding			ovary(1)	1	Breast(9;5.46e-08)					ACGCAGAGATGACAGTACAAA	0.522		NaN											0	0	0	0.045705	0	32	47									
C17orf47	284083	broad.mit.edu	37	17	56619289	56619289	+	Silent	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr17:56619289G>A	uc002iwq.1	-	2	1736	c.1600C>T	c.(1600-1602)CTA>TTA	p.L534L	SEPT4_uc010wnx.1_5'Flank|SEPT4_uc010wny.1_5'Flank	NM_001038704	NP_001033793	Q8NEP4	CQ047_HUMAN	hypothetical protein LOC284083	534										breast(1)	1	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AGACCTTTTAGCCACCAGATG	0.507		NaN											0	0	0	0.023175	0	41	74									
SLC16A5	9121	broad.mit.edu	37	17	73100105	73100105	+	Silent	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr17:73100105C>T	uc002jmr.2	+	6	1566	c.1194C>T	c.(1192-1194)TTC>TTT	p.F398F	SLC16A5_uc002jms.1_Silent_p.F398F|SLC16A5_uc002jmt.2_Silent_p.F398F|SLC16A5_uc002jmu.2_Silent_p.F398F|SLC16A5_uc010wrt.1_Silent_p.F438F	NM_004695	NP_004686	O15375	MOT6_HUMAN	solute carrier family 16, member 5	398	Helical; (Potential).				organic anion transport	integral to plasma membrane|membrane fraction	secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)	1	all_lung(278;0.226)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)		Pyruvic acid(DB00119)	GCTATGTTTTCTACATGTCCA	0.493		NaN											0	0	0	0.024245	0	13	117									
ONECUT2	9480	broad.mit.edu	37	18	55103602	55103602	+	Silent	SNP	C	C	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr18:55103602C>A	uc002lgo.2	+	1	686	c.654C>A	c.(652-654)CCC>CCA	p.P218P		NM_004852	NP_004843	O95948	ONEC2_HUMAN	one cut domain, family member 2	218					organ morphogenesis	nucleus	sequence-specific DNA binding			ovary(2)|central_nervous_system(1)	3		Colorectal(73;0.234)		READ - Rectum adenocarcinoma(59;0.227)|Colorectal(16;0.245)		AGGAGATGCCCGGCATGAGCC	0.687		NaN											1	0	0.00741294	0.043863	0.00751784	20	29									
SBNO2	22904	broad.mit.edu	37	19	1110743	1110743	+	Splice_Site	SNP	C	C	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr19:1110743C>A	uc002lrk.3	-	26	3266	c.3028_splice	c.e26+1	p.D1010_splice	SBNO2_uc002lri.3_5'Flank|SBNO2_uc002lrj.3_Splice_Site_p.D953_splice|SBNO2_uc010dse.2_Splice_Site_p.D993_splice|SBNO2_uc010xgj.1_Intron	NM_014963	NP_055778	Q9Y2G9	SBNO2_HUMAN	strawberry notch homolog 2 isoform 1						macrophage activation involved in immune response|negative regulation of transcription, DNA-dependent|regulation of inflammatory response|transcription, DNA-dependent						0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCTGTGCTCACCCAGGATGCC	0.637		NaN											1	0	1.11015e-26	0.048971	1.24314e-26	52	85									
ATCAY	85300	broad.mit.edu	37	19	3905458	3905458	+	Nonsense_Mutation	SNP	G	G	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr19:3905458G>T	uc002lyy.3	+	4	593	c.163G>T	c.(163-165)GGA>TGA	p.G55*	ATCAY_uc010xhz.1_Nonsense_Mutation_p.G61*	NM_033064	NP_149053	Q86WG3	ATCAY_HUMAN	caytaxin	55					transport		protein binding			breast(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00485)|STAD - Stomach adenocarcinoma(1328;0.183)		AAATTTCAACGGAGCGCATCG	0.498		NaN											1	0	4.35082e-09	0.055883	4.56305e-09	22	23									
COL5A3	50509	broad.mit.edu	37	19	10089574	10089574	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr19:10089574C>T	uc002mmq.1	-	40	3043	c.2957G>A	c.(2956-2958)GGG>GAG	p.G986E		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	986	Triple-helical region.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			CACCGGGTCCCCAGGGCCCCC	0.622		NaN											0	0	0	0.010729	0	11	16									
ATG4D	84971	broad.mit.edu	37	19	10663675	10663675	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr19:10663675C>T	uc002mov.2	+	10	1477	c.1357C>T	c.(1357-1359)CGG>TGG	p.R453W	ATG4D_uc010xlh.1_Missense_Mutation_p.R390W|ATG4D_uc010dxh.2_RNA|ATG4D_uc010dxi.2_RNA|ATG4D_uc010dxj.2_Missense_Mutation_p.R120W	NM_032885	NP_116274	Q86TL0	ATG4D_HUMAN	APG4 autophagy 4 homolog D	453					autophagy|protein transport	cytoplasm	cysteine-type endopeptidase activity				0			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			GCCCACACTCCGGCTCCCTCG	0.617		NaN											0	0	0	0.058154	0	10	83									
LPHN1	22859	broad.mit.edu	37	19	14273534	14273534	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr19:14273534G>C	uc010xnn.1	-	6	1390	c.1094C>G	c.(1093-1095)CCC>CGC	p.P365R	LPHN1_uc010xno.1_Missense_Mutation_p.P360R|uc002myf.2_Intron	NM_001008701	NP_001008701	O94910	LPHN1_HUMAN	latrophilin 1 isoform 1 precursor	365	Olfactomedin-like.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity|sugar binding			ovary(2)|lung(2)|central_nervous_system(1)	5						GAACTGGTAGGGGTTGGGGAA	0.587		NaN											0	0	0	0.008291	0	11	147									
CYP4F2	8529	broad.mit.edu	37	19	15990419	15990419	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr19:15990419G>A	uc002nbs.1	-	11	1359	c.1309C>T	c.(1309-1311)CCT>TCT	p.P437S	CYP4F2_uc010xot.1_Missense_Mutation_p.P288S	NM_001082	NP_001073	P78329	CP4F2_HUMAN	cytochrome P450, family 4, subfamily F,	437					leukotriene metabolic process|long-chain fatty acid metabolic process|very long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|leukotriene-B4 20-monooxygenase activity|oxygen binding|protein binding			ovary(1)|skin(1)	2						CGCACCTCAGGGTCCGGCCAC	0.557		NaN											0	0	0	0.048971	0	72	153									
CYP4F11	57834	broad.mit.edu	37	19	16035572	16035572	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr19:16035572C>T	uc002nbu.2	-	6	682	c.646G>A	c.(646-648)GAG>AAG	p.E216K	CYP4F11_uc010eab.1_Missense_Mutation_p.E216K|CYP4F11_uc002nbt.2_Missense_Mutation_p.E216K	NM_001128932	NP_001122404	Q9HBI6	CP4FB_HUMAN	cytochrome P450 family 4 subfamily F polypeptide	216					inflammatory response|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	aromatase activity|electron carrier activity|heme binding			ovary(1)	1						AGGACTCACTCCTGACAATTG	0.517		NaN											0	0	0	0.047766	0	8	97									
MLL4	9757	broad.mit.edu	37	19	36216719	36216719	+	Nonsense_Mutation	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr19:36216719G>A	uc010eei.2	+	14	3885	c.3885G>A	c.(3883-3885)TGG>TGA	p.W1295*		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	1295	PHD-type 2.				chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GGCGCCACTGGGTGAGAGATG	0.612		NaN											0	0	0	0.021553	0	6	0									
LILRB2	10288	broad.mit.edu	37	19	54782928	54782929	+	Missense_Mutation	DNP	CC	CC	TT	rs141840014		TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr19:54782928_54782929CC>TT	uc002qfb.2	-	6	959_960	c.693_694GG>AA	c.(691-696)CCGGGT>CCAAGT	p.G232S	LILRA6_uc002qew.1_Intron|LILRB2_uc010eri.2_Missense_Mutation_p.G232S|LILRB2_uc010erj.2_RNA|LILRB2_uc002qfc.2_Missense_Mutation_p.G232S|LILRB2_uc010yet.1_Missense_Mutation_p.G116S|LILRB2_uc010yeu.1_Intron	NM_005874	NP_005865	Q8N423	LIRB2_HUMAN	leukocyte immunoglobulin-like receptor,	232	Extracellular (Potential).|Ig-like C2-type 3.				cell surface receptor linked signaling pathway|cell-cell signaling|cellular defense response|immune response|regulation of immune response	integral to plasma membrane|membrane fraction	receptor activity			skin(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		ACGACAGGACCCGGCTGCACTG	0.574		NaN											0	0	0	0.004672	0	7	133									
BRSK1	84446	broad.mit.edu	37	19	55816212	55816212	+	Silent	SNP	C	C	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr19:55816212C>A	uc002qkg.2	+	14	1918	c.1641C>A	c.(1639-1641)GCC>GCA	p.A547A	BRSK1_uc002qkf.2_Silent_p.A563A|BRSK1_uc002qkh.2_Silent_p.A242A	NM_032430	NP_115806	Q8TDC3	BRSK1_HUMAN	BR serine/threonine kinase 1	547					establishment of cell polarity|G2/M transition DNA damage checkpoint|neuron differentiation|response to UV	cell junction|cytoplasm|nucleus	magnesium ion binding|protein serine/threonine kinase activity			ovary(2)|stomach(1)|lung(1)|breast(1)|skin(1)	6		Renal(1328;0.245)	BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0474)		TCGGGGGAGCCGCCTGGAGGA	0.701		NaN											1	0	1.836e-18	0.064281	1.98362e-18	37	4									
PQLC3	130814	broad.mit.edu	37	2	11300786	11300786	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr2:11300786G>A	uc002rbc.2	+	3	395	c.262G>A	c.(262-264)GGG>AGG	p.G88R	PQLC3_uc010yjk.1_Missense_Mutation_p.G88R	NM_152391	NP_689604	Q8N755	PQLC3_HUMAN	PQ loop repeat containing 3 precursor	88						integral to membrane					0	all_hematologic(175;0.0797)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.0978)|OV - Ovarian serous cystadenocarcinoma(76;0.132)		TCATTTTAACGGGAACGTGAA	0.517		NaN											0	0	0	0.023175	0	39	73									
C2orf86	51057	broad.mit.edu	37	2	63380641	63380641	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr2:63380641C>T	uc002sch.2	-	16	2593	c.2147G>A	c.(2146-2148)TGT>TAT	p.C716Y	C2orf86_uc002sce.2_RNA|C2orf86_uc002scf.2_Missense_Mutation_p.C557Y|C2orf86_uc010ypu.1_RNA|C2orf86_uc002scg.2_Missense_Mutation_p.C524Y	NM_015910	NP_056994	O95876	FRITZ_HUMAN	hypothetical protein LOC51057 isoform 2	716					cilium morphogenesis|regulation of embryonic cell shape|regulation of protein localization|septin cytoskeleton organization	cilium axoneme|cytoplasm|cytoskeleton|plasma membrane					0						TTCTGCATTACAGGTATTAGT	0.299		NaN											0	0	0	0.055883	0	22	25									
MPHOSPH10	10199	broad.mit.edu	37	2	71357850	71357850	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr2:71357850G>T	uc002sht.1	+	1	407	c.55G>T	c.(55-57)GGC>TGC	p.G19C	MCEE_uc002shs.2_5'Flank|MPHOSPH10_uc010feb.1_Missense_Mutation_p.G19C	NM_005791	NP_005782	O00566	MPP10_HUMAN	M-phase phosphoprotein 10	19					RNA splicing, via transesterification reactions|rRNA processing	chromosome|nucleolus|small nucleolar ribonucleoprotein complex	protein binding			skin(2)|ovary(1)	3						GACGGAAGTCGGCAAAGCCAC	0.672		NaN											1	0	2.21704e-12	0.016522	2.35972e-12	20	20									
NCAPH	23397	broad.mit.edu	37	2	97035169	97035169	+	Silent	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr2:97035169C>T	uc002svz.1	+	17	2181	c.2097C>T	c.(2095-2097)CCC>CCT	p.P699P	NCAPH_uc010yum.1_Silent_p.P675P|NCAPH_uc010fhw.1_Silent_p.P688P|NCAPH_uc010yun.1_Silent_p.P563P|NCAPH_uc002swa.1_Silent_p.P294P	NM_015341	NP_056156	Q15003	CND2_HUMAN	non-SMC condensin I complex, subunit H	699					cell division|mitotic chromosome condensation	condensin complex|cytoplasm|microtubule cytoskeleton|nucleus				urinary_tract(1)|skin(1)	2		Ovarian(717;0.0221)				CCAGCCTGCCCCCTGTCATGG	0.428		NaN											0	0	0	0.033182	0	39	76									
ZC3H6	376940	broad.mit.edu	37	2	113074110	113074110	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr2:113074110G>A	uc002thq.1	+	6	1205	c.811G>A	c.(811-813)GAA>AAA	p.E271K		NM_198581	NP_940983	P61129	ZC3H6_HUMAN	zinc finger CCCH-type domain containing 6	271							nucleic acid binding|zinc ion binding			ovary(3)|central_nervous_system(1)	4						GCACACAGTGGAACACAAAGG	0.318		NaN											0	0	0	0.016723	0	13	16									
POTEE	445582	broad.mit.edu	37	2	132021608	132021608	+	Silent	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr2:132021608C>T	uc002tsn.2	+	15	2632	c.2580C>T	c.(2578-2580)ACC>ACT	p.T860T	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_Silent_p.T460T|POTEE_uc002tsl.2_Silent_p.T442T|POTEE_uc010fmy.1_Silent_p.T324T	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	protein expressed in prostate, ovary, testis,	860	Actin-like.						ATP binding				0						ACGGGGTCACCCACACTGTGC	0.617		NaN											0	0	0	0.048971	0	61	121									
SPHKAP	80309	broad.mit.edu	37	2	228860382	228860382	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr2:228860382C>T	uc002vpq.2	-	8	4524	c.4477G>A	c.(4477-4479)GAG>AAG	p.E1493K	SPHKAP_uc002vpp.2_Missense_Mutation_p.E1493K|SPHKAP_uc010zlx.1_Intron	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1493						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		GCTTCAGCCTCTGGTACATCT	0.557		NaN											0	0	0	0.014323	0	23	45									
COL6A3	1293	broad.mit.edu	37	2	238287358	238287358	+	Silent	SNP	T	T	C			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr2:238287358T>C	uc002vwl.2	-	6	2703	c.2418A>G	c.(2416-2418)CCA>CCG	p.P806P	COL6A3_uc002vwo.2_Silent_p.P600P|COL6A3_uc010znj.1_Intron|COL6A3_uc002vwq.2_Silent_p.P600P|COL6A3_uc002vwr.2_Silent_p.P399P|COL6A3_uc010znk.1_Intron	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	806	VWFA 4.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GAGGCAAAGCTGGCAGGGAGC	0.527		NaN											0	0	0	0.021022	0	39	65									
SSTR4	6754	broad.mit.edu	37	20	23016850	23016850	+	Missense_Mutation	SNP	C	C	T	rs4988474	by1000genomes	TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr20:23016850C>T	uc002wsr.2	+	1	794	c.730C>T	c.(730-732)CGC>TGC	p.R244C		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	244	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					CGTGGCCCTGCGCGCTGGCTG	0.622		NaN											0	0	0	0.038147	0	8	157									
CST9	128822	broad.mit.edu	37	20	23586272	23586272	+	Nonsense_Mutation	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr20:23586272C>T	uc002wtl.2	-	1	339	c.230G>A	c.(229-231)TGG>TAG	p.W77*		NM_001008693	NP_001008693	Q5W186	CST9_HUMAN	cystatin 9 precursor	77						extracellular region	cysteine-type endopeptidase inhibitor activity			ovary(1)	1	Colorectal(13;0.0993)					ATCCTCCCTCCATGAACTCAG	0.532		NaN											0	0	0	0.048971	0	86	127									
PHF20	51230	broad.mit.edu	37	20	34501269	34501269	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr20:34501269G>A	uc002xek.1	+	11	1771	c.1660G>A	c.(1660-1662)GAA>AAA	p.E554K	PHF20_uc002xei.1_3'UTR|PHF20_uc010gfo.1_3'UTR|PHF20_uc002xej.1_3'UTR	NM_016436	NP_057520	Q9BVI0	PHF20_HUMAN	PHD finger protein 20	554					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			ovary(1)	1	Breast(12;0.00631)|all_lung(11;0.0145)					aaCCAAACCTGGTAATTTTTT	0.284		NaN											0	0	0	0.010729	0	11	25									
TIAM1	7074	broad.mit.edu	37	21	32575281	32575281	+	Silent	SNP	T	T	C			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr21:32575281T>C	uc002yow.1	-	13	2908	c.2436A>G	c.(2434-2436)CTA>CTG	p.L812L	TIAM1_uc011adk.1_Silent_p.L812L|TIAM1_uc011adl.1_Intron	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	812	RBD.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						TGTTTTCTATTAGAAATTTCA	0.388		NaN											0	0	0	0.048971	0	81	88									
KRTAP10-11	386678	broad.mit.edu	37	21	46066461	46066461	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr21:46066461C>T	uc002zfr.3	+	1	131	c.86C>T	c.(85-87)CCC>CTC	p.P29L	C21orf29_uc002zfe.1_Intron|C21orf29_uc010gpv.1_Intron	NM_198692	NP_941965	P60412	KR10B_HUMAN	keratin associated protein 10-11	29	25 X 5 AA repeats of C-C-X(3).|1.					keratin filament				ovary(1)	1						TGCTGTGAGCCCCCCTGCAGC	0.706		NaN											0	0	0	0.048971	0	55	71									
AIFM3	150209	broad.mit.edu	37	22	21335037	21335037	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr22:21335037C>G	uc002ztj.2	+	20	1977	c.1759C>G	c.(1759-1761)CTG>GTG	p.L587V	AIFM3_uc002ztk.2_Intron|AIFM3_uc002ztl.2_Intron|AIFM3_uc011ahx.1_Intron|AIFM3_uc002ztm.1_Intron|LZTR1_uc002ztn.2_Intron|LZTR1_uc002zto.2_5'Flank|LZTR1_uc011ahy.1_5'Flank	NM_144704	NP_653305	Q96NN9	AIFM3_HUMAN	apoptosis-inducing factor,	587					activation of caspase activity by cytochrome c|cell redox homeostasis|electron transport chain|induction of apoptosis|mitochondrial depolarization|transport	endoplasmic reticulum|mitochondrial inner membrane	2 iron, 2 sulfur cluster binding|caspase activator activity|flavin adenine dinucleotide binding|metal ion binding|oxidoreductase activity|protein binding			ovary(2)|lung(2)	4	all_cancers(11;3.71e-26)|all_epithelial(7;1.59e-23)|Lung NSC(8;3.06e-15)|all_lung(8;5.05e-14)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0332)|all_neural(72;0.142)	Lung SC(17;0.0367)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)			TTCGTGAAGGCTGTTTGTGCT	0.522		NaN											0	0	0	0.016522	0	21	220									
AP1B1	162	broad.mit.edu	37	22	29750657	29750657	+	Missense_Mutation	SNP	T	T	C			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr22:29750657T>C	uc003afj.2	-	7	1104	c.920A>G	c.(919-921)AAT>AGT	p.N307S	AP1B1_uc003afi.2_Missense_Mutation_p.N307S|AP1B1_uc003afk.2_Missense_Mutation_p.N307S|AP1B1_uc003afl.2_Missense_Mutation_p.N307S	NM_001127	NP_001118	Q10567	AP1B1_HUMAN	adaptor-related protein complex 1 beta 1 subunit	307					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport|regulation of defense response to virus by virus|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding|protein transporter activity			ovary(1)|skin(1)	2						CACGATGAGATTGATGTTGCG	0.582		NaN											0	0	0	0.008291	0	10	94									
CHKB	1120	broad.mit.edu	37	22	51020239	51020239	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr22:51020239C>T	uc003bms.2	-	3	604	c.386G>A	c.(385-387)CGG>CAG	p.R129Q	CHKB-CPT1B_uc003bmp.2_5'Flank|CHKB-CPT1B_uc003bmt.1_Intron|CHKB-CPT1B_uc003bmu.2_Missense_Mutation_p.R8Q|CHKB_uc003bmv.2_Missense_Mutation_p.R129Q|LOC100144603_uc003bmw.3_5'Flank	NM_005198	NP_005189	Q9Y259	CHKB_HUMAN	choline kinase beta	129					phosphatidylethanolamine biosynthetic process		ATP binding|choline kinase activity|ethanolamine kinase activity				0		all_cancers(38;8.8e-15)|all_epithelial(38;1.12e-12)|all_lung(38;3.07e-05)|Breast(42;6.27e-05)|Lung NSC(38;0.000813)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		all cancers(3;4.04e-77)|OV - Ovarian serous cystadenocarcinoma(4;5.79e-74)|Epithelial(4;6.17e-70)|GBM - Glioblastoma multiforme(4;5.68e-08)|LUAD - Lung adenocarcinoma(64;0.0016)|Lung(4;0.00942)|BRCA - Breast invasive adenocarcinoma(115;0.205)	Choline(DB00122)	CCCCAGCGACCGCTCCGCAAG	0.617		NaN											0	0	0	0.048971	0	49	92									
SCN11A	11280	broad.mit.edu	37	3	38888718	38888718	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr3:38888718C>T	uc011ays.1	-	26	5042	c.4843G>A	c.(4843-4845)GAG>AAG	p.E1615K		NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1615					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	AAAGGGTCCTCACTTTCTTCA	0.368		NaN											0	0	0	0.013537	0	13	144									
SCN11A	11280	broad.mit.edu	37	3	38926797	38926797	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr3:38926797C>G	uc011ays.1	-	17	3245	c.3046G>C	c.(3046-3048)GAG>CAG	p.E1016Q	SCN11A_uc010hhn.1_Missense_Mutation_p.E94Q	NM_014139	NP_054858	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha	1016					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			skin(6)|ovary(1)|haematopoietic_and_lymphoid_tissue(1)|pancreas(1)	9				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	AAACATCTCTCTGGTTGCTTT	0.428		NaN											0	0	0	0.047766	0	8	80									
IQCF1	132141	broad.mit.edu	37	3	51929352	51929352	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr3:51929352G>T	uc003dbv.2	-	4	270	c.172C>A	c.(172-174)CCC>ACC	p.P58T	IQCF1_uc003dbq.3_Intron	NM_152397	NP_689610	Q8N6M8	IQCF1_HUMAN	IQ motif containing F1	58										ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		TTTTCTGGGGGCTTTCAAGAA	0.562		NaN											1	0	1.2476e-16	0.030593	1.34117e-16	30	42									
ITIH4	3700	broad.mit.edu	37	3	52857966	52857966	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr3:52857966C>A	uc003dfz.2	-	10	1262	c.1226G>T	c.(1225-1227)CGG>CTG	p.R409L	ITIH4_uc011bel.1_Missense_Mutation_p.R139L|ITIH4_uc003dfy.2_Missense_Mutation_p.R273L|ITIH4_uc011bem.1_Missense_Mutation_p.R409L|ITIH4_uc011ben.1_Missense_Mutation_p.R409L	NM_002218	NP_002209	Q14624	ITIH4_HUMAN	inter-alpha (globulin) inhibitor H4	409	VWFA.				acute-phase response|hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		GAGGCTGTACCGGCCACTTAC	0.582		NaN											1	0	6.90743e-12	0.064281	7.31575e-12	34	75									
DNASE1L3	1776	broad.mit.edu	37	3	58186750	58186750	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr3:58186750C>T	uc003djo.1	-	5	617	c.520G>A	c.(520-522)GAC>AAC	p.D174N	DNASE1L3_uc011bfd.1_Missense_Mutation_p.D144N|DNASE1L3_uc003djp.1_Missense_Mutation_p.D174N|DNASE1L3_uc003djq.1_Missense_Mutation_p.D174N	NM_004944	NP_004935	Q13609	DNSL3_HUMAN	deoxyribonuclease I-like 3 precursor	174					apoptosis|DNA catabolic process	nucleus	calcium ion binding|DNA binding|endodeoxyribonuclease activity, producing 5'-phosphomonoesters			breast(2)|large_intestine(1)	3				BRCA - Breast invasive adenocarcinoma(55;0.00021)|KIRC - Kidney renal clear cell carcinoma(284;0.0445)|Kidney(284;0.0556)|OV - Ovarian serous cystadenocarcinoma(275;0.202)		TGTTTCACGTCCGTGTAGACC	0.547		NaN											0	0	0	0.048971	0	100	175									
FAM19A4	151647	broad.mit.edu	37	3	68802170	68802170	+	Splice_Site	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr3:68802170C>T	uc003dnh.1	-	4	574	c.131_splice	c.e4-1	p.G44_splice	FAM19A4_uc003dni.1_Splice_Site_p.G44_splice	NM_182522	NP_872328	Q96LR4	F19A4_HUMAN	family with sequence similarity 19 (chemokine							extracellular region				skin(2)	2		Lung NSC(201;0.0198)		BRCA - Breast invasive adenocarcinoma(55;1.38e-05)|Epithelial(33;0.000124)|LUSC - Lung squamous cell carcinoma(21;0.0248)|KIRC - Kidney renal clear cell carcinoma(39;0.0729)|Kidney(39;0.0904)		TGGTGGTGACCTAGTTGGTAA	0.478		NaN											0	0	0	0.028581	0	16	29									
LMOD3	56203	broad.mit.edu	37	3	69168084	69168084	+	Silent	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr3:69168084C>T	uc003dns.2	-	2	1631	c.1422G>A	c.(1420-1422)CAG>CAA	p.Q474Q	LMOD3_uc003dnt.2_Silent_p.Q474Q	NM_198271	NP_938012	Q0VAK6	LMOD3_HUMAN	leiomodin 3 (fetal)	474						cytoplasm|cytoskeleton	tropomyosin binding			ovary(1)	1		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;7.88e-05)|Epithelial(33;0.000839)|LUSC - Lung squamous cell carcinoma(21;0.0119)|Lung(16;0.0191)|KIRC - Kidney renal clear cell carcinoma(39;0.205)|Kidney(39;0.24)		ACTTCGGGGCCTGCGATGGCT	0.562		NaN											0	0	0	0.009096	0	4	68									
ZDHHC23	254887	broad.mit.edu	37	3	113667649	113667649	+	Translation_Start_Site	SNP	C	C	G			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr3:113667649C>G	uc003eau.2	+	2	299	c.0C>G	c.(-2-2)ATCAT>ATGAT		ZDHHC23_uc003eav.2_Intron	NM_173570	NP_775841	Q8IYP9	ZDH23_HUMAN	zinc finger, DHHC domain containing 23							integral to membrane	acyltransferase activity|zinc ion binding			ovary(2)	2						AGGTGCAAATCATGACACAGA	0.483		NaN											0	0	0	0.030466	0	40	31									
MUC4	4585	broad.mit.edu	37	3	195505836	195505836	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr3:195505836G>C	uc011bto.1	-	3	12691	c.12231C>G	c.(12229-12231)CAC>CAG	p.H4077Q	MUC4_uc003fva.2_5'Flank|MUC4_uc003fvb.2_5'Flank|MUC4_uc003fvc.2_5'Flank|MUC4_uc003fvd.2_5'Flank|MUC4_uc003fve.2_5'Flank|MUC4_uc010hzr.2_5'Flank|MUC4_uc011btf.1_Intron|MUC4_uc011btg.1_Intron|MUC4_uc011bth.1_Intron|MUC4_uc011bti.1_Intron|MUC4_uc011btj.1_Intron|MUC4_uc011btk.1_Intron|MUC4_uc011btl.1_Intron|MUC4_uc011btm.1_Intron|MUC4_uc011btn.1_Intron|MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GAGGGGTGGCGTGACCTGTGG	0.597		NaN											0	0	0	0.014758	0	5	4									
FGFR3	2261	broad.mit.edu	37	4	1806088	1806089	+	Missense_Mutation	DNP	GG	GG	TT	rs121913479		TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08			GG	TT	GG	GG		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr4:1806088_1806089GG>TT	uc003gdr.3	+	9	1363_1364	c.1107_1108GG>TT	c.(1105-1110)GCGGGC>GCTTGC	p.G370C	FGFR3_uc003gdu.2_Missense_Mutation_p.G372C|FGFR3_uc003gds.3_Intron|FGFR3_uc003gdq.3_Missense_Mutation_p.G370C	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	370	Extracellular (Potential).		G -> C (in KERSEB, bladder cancer, keratinocytic non-epidermolytic nevus and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.G370C(125)|p.A369A(6)|p.A369_G370>VC(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	CTGACGAGGCGGGCAGTGTGTA	0.688		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.004672	0	101	150									
MXD4	10608	broad.mit.edu	37	4	2252898	2252898	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr4:2252898G>A	uc003geu.1	-	5	417	c.385C>T	c.(385-387)CGC>TGC	p.R129C		NM_006454	NP_006445	Q14582	MAD4_HUMAN	MAD4	129					negative regulation of cell proliferation|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding|transcription corepressor activity				0						TGCTCCAGGCGCCGCTTCAGG	0.662		NaN											0	0	0	0.038147	0	8	10									
ATP8A1	10396	broad.mit.edu	37	4	42545975	42545975	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr4:42545975G>A	uc003gwr.2	-	20	1913	c.1681C>T	c.(1681-1683)CGC>TGC	p.R561C	ATP8A1_uc003gws.2_Missense_Mutation_p.R546C|ATP8A1_uc011byz.1_Missense_Mutation_p.R546C	NM_006095	NP_006086	Q9Y2Q0	AT8A1_HUMAN	ATPase, aminophospholipid transporter (APLT),	561	Cytoplasmic (Potential).				ATP biosynthetic process	chromaffin granule membrane|integral to membrane|plasma membrane	aminophospholipid transporter activity|ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|cation-transporting ATPase activity|magnesium ion binding|phospholipid-translocating ATPase activity			skin(2)|central_nervous_system(1)	3					Phosphatidylserine(DB00144)	GATGGAGTGCGAACAATCACT	0.338		NaN											0	0	0	0.043863	0	16	31									
LRRC66	339977	broad.mit.edu	37	4	52862253	52862253	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr4:52862253C>T	uc003gzi.2	-	4	948	c.935G>A	c.(934-936)CGC>CAC	p.R312H		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	312						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						GCTTTTCATGCGATGCAGATG	0.562		NaN											0	0	0	0.041601	0	28	36									
TECRL	253017	broad.mit.edu	37	4	65170940	65170940	+	Missense_Mutation	SNP	C	C	A	rs141462797		TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr4:65170940C>A	uc003hcv.2	-	7	783	c.674G>T	c.(673-675)TGG>TTG	p.W225L	TECRL_uc003hcw.2_Missense_Mutation_p.W225L	NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2	225	Helical; (Potential).				lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						AGTAAATCCCCAGTAAAAGGC	0.294		NaN											1	0	0.00116845	0.021553	0.0011906	6	115									
EXOSC9	5393	broad.mit.edu	37	4	122723018	122723018	+	Missense_Mutation	SNP	A	A	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr4:122723018A>T	uc003iea.2	+	2	211	c.103A>T	c.(103-105)ATC>TTC	p.I35F	EXOSC9_uc003idz.2_Missense_Mutation_p.I35F|EXOSC9_uc003ieb.2_Missense_Mutation_p.I19F|EXOSC9_uc010inp.1_5'Flank	NM_005033	NP_005024	Q06265	EXOS9_HUMAN	exosome component 9 isoform 2	35	ARE binding.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|immune response|nuclear mRNA surveillance|nuclear polyadenylation-dependent rRNA catabolic process|positive regulation of cell growth|rRNA processing	cytosol|nuclear exosome (RNase complex)|nucleolus|nucleolus|nucleus	3'-5'-exoribonuclease activity|AU-rich element binding|protein binding				0						TTATAGGAACATCAGGATCTC	0.318		NaN											0	0	0	0.059317	0	31	51									
FAT4	79633	broad.mit.edu	37	4	126241857	126241857	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr4:126241857G>C	uc003ifj.3	+	1	4291	c.4291G>C	c.(4291-4293)GAG>CAG	p.E1431Q		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	1431	Cadherin 14.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						GTCTATTGTTGAGAACATTCC	0.423		NaN											0	0	0	0.010729	0	12	154									
ADAM29	11086	broad.mit.edu	37	4	175896928	175896928	+	Silent	SNP	A	A	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr4:175896928A>T	uc003iuc.2	+	5	922	c.252A>T	c.(250-252)ACA>ACT	p.T84T	ADAM29_uc003iud.2_Silent_p.T84T|ADAM29_uc010irr.2_Silent_p.T84T|ADAM29_uc011cki.1_Silent_p.T84T	NM_014269	NP_055084	Q9UKF5	ADA29_HUMAN	ADAM metallopeptidase domain 29 preproprotein	84					proteolysis|spermatogenesis	integral to plasma membrane	metalloendopeptidase activity|zinc ion binding			skin(5)|central_nervous_system(3)|ovary(3)|large_intestine(2)|lung(2)|pancreas(1)	16		Breast(14;0.00908)|Melanoma(52;0.00951)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;3.08e-19)|Epithelial(43;6.24e-18)|OV - Ovarian serous cystadenocarcinoma(60;1.78e-09)|STAD - Stomach adenocarcinoma(60;0.00303)|GBM - Glioblastoma multiforme(59;0.0106)|LUSC - Lung squamous cell carcinoma(193;0.0286)		TCACCTACACAGACCAGGGTG	0.478		NaN											0	0	0	0.049695	0	20	38									
MTNR1A	4543	broad.mit.edu	37	4	187455151	187455151	+	Missense_Mutation	SNP	T	T	C			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr4:187455151T>C	uc003izd.1	-	2	763	c.745A>G	c.(745-747)ATT>GTT	p.I249V		NM_005958	NP_005949	P48039	MTR1A_HUMAN	melatonin receptor 1A	249	Helical; Name=6; (Potential).				circadian rhythm|G-protein signaling, coupled to cyclic nucleotide second messenger|mating behavior	integral to plasma membrane	melatonin receptor activity			ovary(1)|skin(1)|breast(1)|central_nervous_system(1)|pancreas(1)	5		all_cancers(14;6.39e-56)|all_epithelial(14;1.48e-41)|all_lung(41;2.45e-15)|Lung NSC(41;7.26e-15)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00335)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|Renal(120;0.0183)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;7.63e-12)|BRCA - Breast invasive adenocarcinoma(30;6.68e-07)|GBM - Glioblastoma multiforme(59;3.44e-05)|LUSC - Lung squamous cell carcinoma(40;0.000106)|STAD - Stomach adenocarcinoma(60;0.000279)|READ - Rectum adenocarcinoma(43;0.159)	Melatonin(DB01065)|Ramelteon(DB00980)	GCCCAGCAAATGGCAAAAAGG	0.527		NaN											0	0	0	0.048971	0	51	109									
DNAH5	1767	broad.mit.edu	37	5	13766144	13766144	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:13766144G>A	uc003jfd.2	-	59	10084	c.10042C>T	c.(10042-10044)CCC>TCC	p.P3348S	DNAH5_uc003jfc.2_5'UTR	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3348	Stalk (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TGCCAGGAGGGCATGGTACAG	0.468		NaN							Kartagener_syndrome				0	0	0	0.038147	0	8	147									
NPR3	4883	broad.mit.edu	37	5	32786414	32786414	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:32786414G>A	uc003jhv.2	+	8	1807	c.1589G>A	c.(1588-1590)CGG>CAG	p.R530Q	NPR3_uc011cnz.1_Missense_Mutation_p.R313Q|NPR3_uc003jhu.2_Missense_Mutation_p.R529Q|C5orf23_uc003jhw.1_5'Flank	NM_000908	NP_000899	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase	530	Cytoplasmic (Potential).				osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			ovary(1)|central_nervous_system(1)	2					Nesiritide(DB04899)	CGGGAATTACGGGAAGATTCC	0.418		NaN											0	0	0	0.038147	0	7	13									
ADAMTS12	81792	broad.mit.edu	37	5	33576479	33576479	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:33576479C>G	uc003jia.1	-	19	3815	c.3652G>C	c.(3652-3654)GAA>CAA	p.E1218Q	ADAMTS12_uc010iuq.1_Missense_Mutation_p.E1133Q	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1218	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						AGCAGTCCTTCCATTACTGTG	0.542		NaN								HNSCC(64;0.19)			0	0	0	0.047766	0	9	145									
ADAMTS12	81792	broad.mit.edu	37	5	33576554	33576554	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:33576554C>G	uc003jia.1	-	19	3740	c.3577G>C	c.(3577-3579)GAA>CAA	p.E1193Q	ADAMTS12_uc010iuq.1_Missense_Mutation_p.E1108Q	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1193	Spacer 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						AGTGGCATTTCTGTACTTTCC	0.512		NaN								HNSCC(64;0.19)			0	0	0	0.043863	0	16	140									
ADAMTS12	81792	broad.mit.edu	37	5	33881544	33881544	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:33881544G>T	uc003jia.1	-	2	332	c.169C>A	c.(169-171)CCA>ACA	p.P57T	ADAMTS12_uc010iuq.1_Missense_Mutation_p.P57T|ADAMTS12_uc003jib.1_Missense_Mutation_p.P57T	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	57					proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						ACTCGGACTGGACCCACCACG	0.488		NaN								HNSCC(64;0.19)			1	0	6.40141e-05	0.010729	6.55383e-05	12	213									
PARP8	79668	broad.mit.edu	37	5	50074470	50074470	+	Missense_Mutation	SNP	A	A	G			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:50074470A>G	uc003jon.3	+	10	838	c.656A>G	c.(655-657)TAT>TGT	p.Y219C	PARP8_uc011cpz.1_Missense_Mutation_p.Y111C|PARP8_uc003joo.2_Missense_Mutation_p.Y219C|PARP8_uc003jop.2_Missense_Mutation_p.Y219C	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	219						intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)				CTTACACAGTATTTAAATGGC	0.323		NaN											0	0	0	0.009096	0	4	22									
ANKRD55	79722	broad.mit.edu	37	5	55422846	55422846	+	Missense_Mutation	SNP	A	A	G			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:55422846A>G	uc003jqu.2	-	8	852	c.700T>C	c.(700-702)TGT>CGT	p.C234R		NM_024669	NP_078945	Q3KP44	ANR55_HUMAN	ankyrin repeat domain 55 isoform 1	233	ANK 7.									skin(1)	1		Lung NSC(810;8.69e-05)|Prostate(74;0.00634)|Breast(144;0.0334)|Ovarian(174;0.223)				ATATGTACACATGTCTTCCCA	0.498		NaN											0	0	0	0.048971	0	60	122									
ADAMTS6	11174	broad.mit.edu	37	5	64447760	64447760	+	Missense_Mutation	SNP	A	A	G			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:64447760A>G	uc003jtp.2	-	25	4071	c.3257T>C	c.(3256-3258)GTG>GCG	p.V1086A	ADAMTS6_uc003jto.2_RNA|ADAMTS6_uc003jtq.2_RNA	NM_197941	NP_922932	Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1086	PLAC.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		CACTTTATTCACATCTTTGCA	0.458		NaN											0	0	0	0.030593	0	30	52									
POLK	51426	broad.mit.edu	37	5	74880637	74880637	+	Missense_Mutation	SNP	T	T	C			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:74880637T>C	uc003kdw.2	+	9	1208	c.1112T>C	c.(1111-1113)ATT>ACT	p.I371T	POLK_uc003kdx.2_RNA|POLK_uc003kdy.2_RNA|POLK_uc003keb.2_Missense_Mutation_p.I371T|POLK_uc010izq.2_Intron|POLK_uc003kec.2_Missense_Mutation_p.I281T|POLK_uc010izr.2_RNA|POLK_uc010izs.2_RNA|POLK_uc003ked.2_Missense_Mutation_p.I281T|POLK_uc003kee.2_Missense_Mutation_p.I371T|POLK_uc003kef.2_Missense_Mutation_p.I281T	NM_016218	NP_057302	Q9UBT6	POLK_HUMAN	DNA-directed DNA polymerase kappa	371					DNA replication|nucleotide-excision repair, DNA gap filling	nucleus	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding			ovary(2)|kidney(2)	4		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)|Prostate(461;0.184)		OV - Ovarian serous cystadenocarcinoma(47;2.9e-54)|all cancers(79;1.27e-42)		CTTGGAATTATTACATGTACA	0.333		NaN						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.062417	0	23	33									
CHD1	1105	broad.mit.edu	37	5	98232075	98232075	+	Missense_Mutation	SNP	T	T	C			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:98232075T>C	uc003knf.2	-	11	1713	c.1565A>G	c.(1564-1566)TAT>TGT	p.Y522C		NM_001270	NP_001261	O14646	CHD1_HUMAN	chromodomain helicase DNA binding protein 1	522	Helicase ATP-binding.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|methylated histone residue binding			lung(2)|ovary(1)|breast(1)|pancreas(1)	5		all_cancers(142;5.36e-08)|all_epithelial(76;6.97e-11)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|all_lung(232;0.00119)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0717)	Epirubicin(DB00445)	ATGAAACAAATAATTCAGAAA	0.363		NaN											0	0	0	0.021553	0	6	75									
MEGF10	84466	broad.mit.edu	37	5	126732390	126732390	+	Silent	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:126732390G>A	uc003kuh.3	+	7	941	c.579G>A	c.(577-579)CAG>CAA	p.Q193Q	MEGF10_uc010jdc.1_Silent_p.Q193Q|MEGF10_uc010jdd.1_Silent_p.Q193Q|MEGF10_uc003kui.3_Silent_p.Q193Q	NM_032446	NP_115822	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10 precursor	193	Extracellular (Potential).|EGF-like 3.|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				ovary(4)	4		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		ACTGTCATCAGAGATGCCAGT	0.642		NaN											0	0	0	0.048971	0	56	80									
FNIP1	96459	broad.mit.edu	37	5	131006321	131006321	+	Silent	SNP	T	T	C			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:131006321T>C	uc003kvs.1	-	15	3085	c.2943A>G	c.(2941-2943)TCA>TCG	p.S981S	RAPGEF6_uc003kvp.1_Intron|FNIP1_uc003kvt.1_Silent_p.S953S	NM_133372	NP_588613	Q8TF40	FNIP1_HUMAN	folliculin interacting protein 1 isoform 1	981					regulation of protein phosphorylation	cytoplasm	protein binding			pancreas(1)|skin(1)	2		all_cancers(142;0.00347)|Lung NSC(810;0.106)|all_lung(232;0.123)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	Lung(113;0.0665)		CGATTAACTTTGACCTGGAAG	0.373		NaN											0	0	0	0.033182	0	43	60									
PCDHA2	56146	broad.mit.edu	37	5	140175218	140175218	+	Silent	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:140175218G>A	uc003lhd.2	+	1	775	c.669G>A	c.(667-669)ACG>ACA	p.T223T	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhc.1_Silent_p.T223T|PCDHA2_uc011czy.1_Silent_p.T223T	NM_018905	NP_061728	Q9Y5H9	PCDA2_HUMAN	protocadherin alpha 2 isoform 1 precursor	223	Extracellular (Potential).|Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGAGCTCACGGGCACCGTTC	0.418		NaN											0	0	0	0.048971	0	64	72									
PCDHA8	56140	broad.mit.edu	37	5	140221088	140221088	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:140221088C>A	uc003lhs.2	+	1	182	c.182C>A	c.(181-183)CCG>CAG	p.P61Q	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhr.1_Missense_Mutation_p.P61Q	NM_018911	NP_061734	Q9Y5H6	PCDA8_HUMAN	protocadherin alpha 8 isoform 1 precursor	61	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			upper_aerodigestive_tract(1)|ovary(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGCTGGTGCCGCGCCTGTTC	0.637		NaN											1	0	6.00419e-47	0.048971	6.97784e-47	100	149									
PCDHGA3	56112	broad.mit.edu	37	5	140725934	140725934	+	Silent	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:140725934G>A	uc003ljm.1	+	1	2334	c.2334G>A	c.(2332-2334)ACG>ACA	p.T778T	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc010jfx.1_Silent_p.T538T|PCDHGA3_uc011dap.1_Silent_p.T778T	NM_018916	NP_061739	Q9Y5H0	PCDG3_HUMAN	protocadherin gamma subfamily A, 3 isoform 1	778	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATGCGGACACGCTCATCAGCC	0.522		NaN											0	0	0	0.016723	0	14	207									
PCDHGB2	56103	broad.mit.edu	37	5	140740651	140740651	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:140740651C>G	uc003ljs.1	+	1	949	c.949C>G	c.(949-951)CTG>GTG	p.L317V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc011dar.1_Missense_Mutation_p.L317V	NM_018923	NP_061746	Q9Y5G2	PCDGE_HUMAN	protocadherin gamma subfamily B, 2 isoform 1	317	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TAGTTACACTCTGAGTATCGA	0.388		NaN											0	0	0	0.009096	0	4	35									
SPRY4	81848	broad.mit.edu	37	5	141694316	141694316	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:141694316C>A	uc003lml.2	-	2	617	c.358G>T	c.(358-360)GTG>TTG	p.V120L	SPRY4_uc010jgi.1_Missense_Mutation_p.V143L	NM_001127496	NP_001120968	Q9C004	SPY4_HUMAN	sprouty homolog 4 isoform 2	120					multicellular organismal development	cytoplasm|ruffle membrane	protein binding			ovary(1)|lung(1)	2		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGTCAGCCACGGGTGGTGGT	0.662		NaN							Testicular_Cancer_Familial_Clustering_of				1	0	2.73381e-35	0.048971	3.12643e-35	57	94									
RBM22	55696	broad.mit.edu	37	5	150075243	150075243	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:150075243C>T	uc003lst.2	-	7	693	c.571G>A	c.(571-573)GAC>AAC	p.D191N		NM_018047	NP_060517	Q9NW64	RBM22_HUMAN	RNA binding motif protein 22	191					protein import into nucleus, translocation	catalytic step 2 spliceosome|cytoplasm	calcium-dependent protein binding|nucleotide binding|RNA binding|zinc ion binding				0		Medulloblastoma(196;0.167)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			GCAAGGGGGTCATCTGGATCT	0.413		NaN											0	0	0	0.058154	0	8	52									
SLU7	10569	broad.mit.edu	37	5	159835026	159835026	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:159835026C>A	uc003lyg.2	-	9	1024	c.869G>T	c.(868-870)AGA>ATA	p.R290I		NM_006425	NP_006416	O95391	SLU7_HUMAN	step II splicing factor SLU7	290					alternative nuclear mRNA splicing, via spliceosome|nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|cytoplasm|nuclear speck|small nuclear ribonucleoprotein complex	pre-mRNA 3'-splice site binding|second spliceosomal transesterification activity|zinc ion binding			ovary(1)	1	Renal(175;0.00196)	Medulloblastoma(196;0.0354)|all_neural(177;0.116)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCTCATTGCTCTAGTTTTTGG	0.299		NaN											1	0	1.61863e-15	0.048971	1.73137e-15	45	75									
SLIT3	6586	broad.mit.edu	37	5	168244341	168244341	+	Missense_Mutation	SNP	C	C	T	rs143627388		TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:168244341C>T	uc003mab.2	-	8	1177	c.757G>A	c.(757-759)GTG>ATG	p.V253M	SLIT3_uc010jjg.2_Missense_Mutation_p.V253M|SLIT3_uc010jji.2_Missense_Mutation_p.V253M|SLIT3_uc003mac.1_Missense_Mutation_p.V50M	NM_003062	NP_003053	O75094	SLIT3_HUMAN	slit homolog 3 precursor	253	LRRCT 1.				apoptosis involved in luteolysis|axon extension involved in axon guidance|cellular response to hormone stimulus|negative chemotaxis|negative regulation of cell growth|negative regulation of chemokine-mediated signaling pathway|response to cortisol stimulus|Roundabout signaling pathway	extracellular space|mitochondrion	calcium ion binding|Roundabout binding			ovary(3)|skin(1)	4	Renal(175;0.000159)|Lung NSC(126;0.0174)|all_lung(126;0.0392)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			ACATCCGCCACGTTGAAGCCC	0.597		NaN											0	0	0	0.038147	0	8	91									
NEDD9	4739	broad.mit.edu	37	6	11190347	11190347	+	Silent	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr6:11190347C>T	uc003mzv.2	-	5	1922	c.1755G>A	c.(1753-1755)CAG>CAA	p.Q585Q	NEDD9_uc010joz.2_Silent_p.Q585Q|NEDD9_uc003mzw.3_Silent_p.Q439Q	NM_006403	NP_006394	Q14511	CASL_HUMAN	neural precursor cell expressed, developmentally	585					actin filament bundle assembly|cell adhesion|cell division|integrin-mediated signaling pathway|mitosis|regulation of growth	cell cortex|focal adhesion|Golgi apparatus|lamellipodium|nucleus	protein binding				0	Breast(50;0.0768)|Ovarian(93;0.152)	all_hematologic(90;0.135)	Epithelial(50;0.0647)|all cancers(50;0.179)			GCAGCTGTCCCTGGGAGCCAC	0.632		NaN											0	0	0	0.045705	0	32	65									
FAM65B	9750	broad.mit.edu	37	6	24850033	24850033	+	Nonsense_Mutation	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr6:24850033C>T	uc003neo.1	-	11	1120	c.944G>A	c.(943-945)TGG>TAG	p.W315*	FAM65B_uc011djs.1_Nonsense_Mutation_p.W344*|FAM65B_uc011dju.1_Nonsense_Mutation_p.W349*|FAM65B_uc003nep.2_Nonsense_Mutation_p.W315*|FAM65B_uc011djt.1_Nonsense_Mutation_p.W315*	NM_014722	NP_055537	Q9Y4F9	FA65B_HUMAN	hypothetical protein LOC9750 isoform 1	315					cell differentiation|muscle organ development	cytoskeleton|filopodium|mitochondrion	binding			ovary(1)	1						CACTTACTACCAGGTGATTTC	0.358		NaN											0	0	0	0.024334	0	27	374									
HIST1H1C	3006	broad.mit.edu	37	6	26056507	26056507	+	Silent	SNP	G	G	A	rs150897775		TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr6:26056507G>A	uc003nfw.2	-	1	193	c.150C>T	c.(148-150)GCC>GCT	p.A50A		NM_005319	NP_005310	P16403	H12_HUMAN	histone cluster 1, H1c	50	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)|skin(2)	5						GCTCTTTAGAGGCGGCCACAG	0.567		NaN											0	0	0	0.048971	0	55	89									
ABT1	29777	broad.mit.edu	37	6	26598817	26598817	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr6:26598817G>A	uc003nii.2	+	3	794	c.763G>A	c.(763-765)GGA>AGA	p.G255R		NM_013375	NP_037507	Q9ULW3	ABT1_HUMAN	activator of basal transcription 1	255					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleolus	DNA binding|nucleotide binding|protein binding|RNA binding|transcription coactivator activity			ovary(1)	1						CAGGATCTTTGGAGCCCCGCC	0.662		NaN											0	0	0	0.024334	0	26	41									
GABBR1	2550	broad.mit.edu	37	6	29589570	29589570	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr6:29589570C>T	uc003nmt.3	-	10	1426	c.1090G>A	c.(1090-1092)GGA>AGA	p.G364R	GABBR1_uc003nmp.3_Missense_Mutation_p.G247R|GABBR1_uc003nms.3_Missense_Mutation_p.G247R|GABBR1_uc003nmu.3_Missense_Mutation_p.G302R|GABBR1_uc011dlr.1_Missense_Mutation_p.G187R|GABBR1_uc011dls.1_Missense_Mutation_p.G364R	NM_001470	NP_001461	Q9UBS5	GABR1_HUMAN	gamma-aminobutyric acid (GABA) B receptor 1	364	Extracellular (Potential).				gamma-aminobutyric acid signaling pathway|negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|extracellular region|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity	p.G364G(1)		ovary(5)|liver(1)|skin(1)	7					Baclofen(DB00181)|Progabide(DB00837)	TAGAAAAGTCCCACGATGATT	0.527		NaN											0	0	0	0.048971	0	43	54									
PSORS1C1	170679	broad.mit.edu	37	6	31107475	31107475	+	Silent	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr6:31107475G>A	uc003nsl.1	+	6	499	c.225G>A	c.(223-225)CAG>CAA	p.Q75Q	PSORS1C1_uc010jsj.1_Silent_p.Q24Q|PSORS1C1_uc003nsn.1_RNA|PSORS1C2_uc003nso.3_5'Flank	NM_014068	NP_054787	Q9UIG5	PS1C1_HUMAN	SEEK1 protein	75										ovary(1)	1						CAGCCACCCAGGATGACTGCA	0.547		NaN											0	0	0	0.045705	0	34	33									
DDAH2	23564	broad.mit.edu	37	6	31696843	31696843	+	Silent	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr6:31696843G>A	uc003nwp.2	-	1	727	c.96C>T	c.(94-96)GGC>GGT	p.G32G	DDAH2_uc003nwq.2_Silent_p.G32G	NM_013974	NP_039268	O95865	DDAH2_HUMAN	dimethylarginine dimethylaminohydrolase 2	32					anti-apoptosis|arginine catabolic process|citrulline metabolic process|nitric oxide biosynthetic process|nitric oxide mediated signal transduction	cytoplasm	dimethylargininase activity|protein binding				0					L-Citrulline(DB00155)	GAGCGGGAAGGCCAGCCCCCG	0.677		NaN											0	0	0	0.048971	0	57	75									
VARS	7407	broad.mit.edu	37	6	31750569	31750569	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr6:31750569G>A	uc003nxe.2	-	15	2239	c.1816C>T	c.(1816-1818)CGG>TGG	p.R606W	VARS_uc003nxf.1_5'Flank|VARS_uc011doi.1_Intron	NM_006295	NP_006286	P26640	SYVC_HUMAN	valyl-tRNA synthetase	606					translational elongation|valyl-tRNA aminoacylation	cytosol	ATP binding|protein binding|valine-tRNA ligase activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3					L-Valine(DB00161)	AGCCCGTGCCGCTGCCCAACT	0.607		NaN											0	0	0	0.014758	0	5	73									
DST	667	broad.mit.edu	37	6	56479254	56479254	+	Missense_Mutation	SNP	T	T	G			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr6:56479254T>G	uc003pdf.2	-	36	4887	c.4859A>C	c.(4858-4860)CAT>CCT	p.H1620P	DST_uc003pcz.3_Missense_Mutation_p.H1442P|DST_uc011dxj.1_Missense_Mutation_p.H1471P|DST_uc011dxk.1_Missense_Mutation_p.H1482P|DST_uc003pcy.3_Missense_Mutation_p.H1116P|DST_uc003pdb.2_Missense_Mutation_p.H1116P	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity	p.G1620D(1)		ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TTTTTCAACATGTTCTTTCTT	0.368		NaN											0	0	0	0.02938	0	7	15									
KHDRBS2	202559	broad.mit.edu	37	6	62442653	62442653	+	Missense_Mutation	SNP	T	T	C			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr6:62442653T>C	uc003peg.2	-	7	1074	c.827A>G	c.(826-828)TAC>TGC	p.Y276C		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal	276					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		TTCACCCCCGTAGCCATCATC	0.383		NaN											0	0	0	0.030593	0	26	43									
CD109	135228	broad.mit.edu	37	6	74473393	74473393	+	Silent	SNP	C	C	G			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr6:74473393C>G	uc003php.2	+	10	1517	c.1092C>G	c.(1090-1092)CTC>CTG	p.L364L	CD109_uc010kaz.2_Silent_p.L364L|CD109_uc003phq.2_Silent_p.L364L|CD109_uc010kba.2_Silent_p.L287L	NM_133493	NP_598000	Q6YHK3	CD109_HUMAN	CD109 antigen isoform 1 precursor	364						anchored to membrane|extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			large_intestine(2)|ovary(2)	4						AGCCATCTCTCAACTTCACAG	0.318		NaN											0	0	0	0.049695	0	20	35									
ORC3L	23595	broad.mit.edu	37	6	88376826	88376826	+	Silent	SNP	A	A	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr6:88376826A>T	uc003pmh.2	+	20	2165	c.2121A>T	c.(2119-2121)ACA>ACT	p.T707T	ORC3L_uc003pmg.2_Silent_p.T708T|ORC3L_uc003pmi.2_Silent_p.T670T|ORC3L_uc011dzo.1_Silent_p.T564T|ORC3L_uc011dzp.1_Silent_p.T564T|ORC3L_uc003pmj.1_RNA	NM_012381	NP_036513	Q9UBD5	ORC3_HUMAN	origin recognition complex, subunit 3 isoform 2	707					cell cycle checkpoint|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	nuclear origin of replication recognition complex|nucleoplasm	DNA replication origin binding|protein binding				0		all_cancers(76;9.05e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;5.29e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.000114)		BRCA - Breast invasive adenocarcinoma(108;0.0469)		CAAGACTAACATGGGGAGGCT	0.393		NaN											0	0	0	0.062417	0	21	30									
REV3L	5980	broad.mit.edu	37	6	111636553	111636553	+	Missense_Mutation	SNP	C	C	G			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr6:111636553C>G	uc003puy.3	-	27	8706	c.8383G>C	c.(8383-8385)GAG>CAG	p.E2795Q	REV3L_uc003pux.3_Missense_Mutation_p.E2717Q|REV3L_uc003puz.3_Missense_Mutation_p.E2717Q|REV3L_uc003pva.1_RNA	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	2795					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		AAAGACTGCTCCTTAGTGGCT	0.343		NaN						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.016723	0	14	23									
UTRN	7402	broad.mit.edu	37	6	144863938	144863938	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr6:144863938G>A	uc003qkt.2	+	45	6619	c.6527G>A	c.(6526-6528)AGA>AAA	p.R2176K		NM_007124	NP_009055	P46939	UTRO_HUMAN	utrophin	2176					muscle contraction|muscle organ development|positive regulation of cell-matrix adhesion	cell junction|cytoplasm|cytoskeleton|membrane fraction|nucleus|postsynaptic membrane	actin binding|calcium ion binding|zinc ion binding			ovary(4)|pancreas(1)	5		Ovarian(120;0.218)		OV - Ovarian serous cystadenocarcinoma(155;5.72e-07)|GBM - Glioblastoma multiforme(68;4.9e-05)|Colorectal(48;0.213)		TAGATTTGCAGAGAGGTGCCT	0.393		NaN											0	0	0	0.016723	0	11	13									
SNX13	23161	broad.mit.edu	37	7	17843094	17843094	+	Missense_Mutation	SNP	A	A	G			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr7:17843094A>G	uc003stw.1	-	21	2420	c.2207T>C	c.(2206-2208)ATG>ACG	p.M736T	SNX13_uc003stv.2_Missense_Mutation_p.M725T|SNX13_uc010kuc.2_Missense_Mutation_p.M522T|SNX13_uc010kub.2_Missense_Mutation_p.M131T			Q9Y5W8	SNX13_HUMAN	SubName: Full=Putative uncharacterized protein SNX13; SubName: Full=Sorting nexin 13, isoform CRA_g;	736					cell communication|intracellular protein transport|negative regulation of signal transduction|positive regulation of GTPase activity	early endosome membrane	phosphatidylinositol binding|signal transducer activity			central_nervous_system(2)|kidney(1)	3	Lung NSC(10;0.0261)|all_lung(11;0.0521)					CATTTTGCCCATGTTGTCTGA	0.338		NaN											0	0	0	0.020292	0	14	16									
DNAH11	8701	broad.mit.edu	37	7	21721207	21721207	+	Missense_Mutation	SNP	T	T	C			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr7:21721207T>C	uc003svc.2	+	31	5418	c.5387T>C	c.(5386-5388)CTT>CCT	p.L1796P		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1796	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						CTGGGAGAACTTCCACCTGGA	0.388		NaN							Kartagener_syndrome				0	0	0	0.043863	0	19	39									
ZAN	7455	broad.mit.edu	37	7	100365467	100365467	+	Missense_Mutation	SNP	G	G	A	rs74848966	by1000genomes	TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr7:100365467G>A	uc003uwj.2	+	26	5039	c.4874G>A	c.(4873-4875)CGG>CAG	p.R1625Q	ZAN_uc003uwk.2_Missense_Mutation_p.R1625Q|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kkd.1_Missense_Mutation_p.R202Q	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	1625	Extracellular (Potential).|VWFD 2.				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			AATGGCCATCGGGTGGCCCTA	0.498		NaN											0	0	0	0.0333	0	18	33									
PIK3CG	5294	broad.mit.edu	37	7	106509636	106509636	+	Nonsense_Mutation	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr7:106509636C>T	uc003vdv.3	+	2	1715	c.1630C>T	c.(1630-1632)CGA>TGA	p.R544*	PIK3CG_uc003vdu.2_Nonsense_Mutation_p.R544*|PIK3CG_uc003vdw.2_Nonsense_Mutation_p.R544*	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	544					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						GGACCGGGTTCGAGCAGAAAT	0.542		NaN											0	0	0	0.039052	0	43	66									
PLXNA4	91584	broad.mit.edu	37	7	131865461	131865461	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr7:131865461C>T	uc003vra.3	-	19	3752	c.3523G>A	c.(3523-3525)GGC>AGC	p.G1175S		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1175	IPT/TIG 4.|Extracellular (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						TTCACGTTGCCCCCAGCCACA	0.597		NaN											0	0	0	0.014758	0	4	62									
HIPK2	28996	broad.mit.edu	37	7	139416296	139416296	+	Missense_Mutation	SNP	T	T	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr7:139416296T>A	uc003vvf.3	-	2	712	c.538A>T	c.(538-540)AGC>TGC	p.S180C	HIPK2_uc003vvd.3_Missense_Mutation_p.S180C	NM_022740	NP_073577	Q9H2X6	HIPK2_HUMAN	homeodomain interacting protein kinase 2 isoform	180	Transcriptional corepression (By similarity).				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			ovary(3)|central_nervous_system(3)|skin(1)	7	Melanoma(164;0.205)					TCGCCCTCGCTGTTGGAGCCG	0.572		NaN											0	0	0	0.048971	0	66	83									
ESYT2	57488	broad.mit.edu	37	7	158528300	158528300	+	Splice_Site	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr7:158528300C>T	uc003wob.1	-	20	2547	c.2481_splice	c.e20-1	p.S827_splice	ESYT2_uc003wny.1_Splice_Site|ESYT2_uc003wnz.1_Splice_Site_p.S266_splice|ESYT2_uc003woa.1_Splice_Site_p.S404_splice	NM_020728	NP_065779	A0FGR8	ESYT2_HUMAN	family with sequence similarity 62 (C2 domain							integral to membrane|plasma membrane				central_nervous_system(2)|kidney(1)	3						GAAATCAAAGCTGAAATAGGA	0.428		NaN											0	0	0	0.048971	0	66	83									
PINX1	54984	broad.mit.edu	37	8	10623339	10623339	+	Missense_Mutation	SNP	C	C	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr8:10623339C>T	uc003wth.2	-	7	592	c.559G>A	c.(559-561)GCA>ACA	p.A187T	SOX7_uc011kwz.1_Intron|PINX1_uc003wti.2_Missense_Mutation_p.G161D	NM_017884	NP_060354	Q96BK5	PINX1_HUMAN	PIN2-interacting protein 1	187					mitotic metaphase plate congression|negative regulation of cell proliferation	chromosome, telomeric region|condensed chromosome kinetochore|mitochondrion|nuclear chromosome|nucleolus|spindle	protein binding|telomerase inhibitor activity|telomeric RNA binding			lung(1)|kidney(1)|skin(1)	3				Kidney(29;0.0595)|COAD - Colon adenocarcinoma(149;0.105)|KIRC - Kidney renal clear cell carcinoma(542;0.201)		TTCAGTGCTGCCATCCGCTTG	0.547		NaN											0	0	0	0.048971	0	162	171									
CNBD1	168975	broad.mit.edu	37	8	87951882	87951882	+	Missense_Mutation	SNP	A	A	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr8:87951882A>T	uc003ydy.2	+	4	379	c.331A>T	c.(331-333)ATA>TTA	p.I111L		NM_173538	NP_775809	Q8NA66	CNBD1_HUMAN	cyclic nucleotide binding domain containing 1	111										ovary(3)	3						TTCTAACAATATAGCTGTCCA	0.348		NaN											0	0	0	0.064281	0	33	58									
FER1L6	654463	broad.mit.edu	37	8	125113410	125113410	+	Missense_Mutation	SNP	C	C	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr8:125113410C>A	uc003yqw.2	+	38	5162	c.4956C>A	c.(4954-4956)AAC>AAA	p.N1652K	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1652	C2 6.|Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			GAGAGGGCAACTTCAACTGGC	0.433		NaN											1	0	3.73808e-20	0.027356	4.07963e-20	29	50									
COL22A1	169044	broad.mit.edu	37	8	139606409	139606409	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr8:139606409G>A	uc003yvd.2	-	63	4913	c.4466C>T	c.(4465-4467)CCG>CTG	p.P1489L	COL22A1_uc011ljo.1_Missense_Mutation_p.P769L	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1489	Pro-rich.|Gly-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CATGTACGCCGGGGGCATCTG	0.592		NaN								HNSCC(7;0.00092)			0	0	0	0.048971	0	44	52									
DENND3	22898	broad.mit.edu	37	8	142151356	142151356	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr8:142151356G>A	uc003yvy.2	+	4	594	c.316G>A	c.(316-318)GTG>ATG	p.V106M	DENND3_uc003yvw.1_Missense_Mutation_p.V119M|DENND3_uc003yvx.2_Silent_p.S184S|DENND3_uc010mep.2_Missense_Mutation_p.V119M	NM_014957	NP_055772	A2RUS2	DEND3_HUMAN	DENN/MADD domain containing 3	106	DENN.									ovary(1)	1	all_cancers(97;7.36e-15)|all_epithelial(106;2.33e-13)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.105)			TGGCTGCTTCGTGCCCTTCGC	0.577		NaN											0	0	0	0.020292	0	14	144									
TSNARE1	203062	broad.mit.edu	37	8	143399942	143399942	+	Missense_Mutation	SNP	A	A	G			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr8:143399942A>G	uc003ywk.2	-	7	1065	c.947T>C	c.(946-948)GTG>GCG	p.V316A	TSNARE1_uc011lju.1_Missense_Mutation_p.V316A|TSNARE1_uc003ywj.2_Missense_Mutation_p.V316A|TSNARE1_uc003ywl.3_Missense_Mutation_p.V97A	NM_145003	NP_659440	Q96NA8	TSNA1_HUMAN	t-SNARE domain containing 1	316					vesicle-mediated transport	integral to membrane					0	all_cancers(97;7.39e-11)|all_epithelial(106;8.98e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000332)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					CATCTGCTTCACGGAGCTGGC	0.662		NaN											0	0	0	0.048971	0	62	125									
BAI1	575	broad.mit.edu	37	8	143599522	143599522	+	Silent	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr8:143599522G>A	uc003ywm.2	+	18	3024	c.2841G>A	c.(2839-2841)CCG>CCA	p.P947P		NM_001702	NP_001693	O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	947	Extracellular (Potential).				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|pancreas(1)	8	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					CGACTCTGCCGTCGGTGACGC	0.647		NaN											0	0	0	0.030466	0	38	65									
FBP1	2203	broad.mit.edu	37	9	97365704	97365704	+	Missense_Mutation	SNP	G	G	T			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr9:97365704G>T	uc004auw.3	-	7	1307	c.976C>A	c.(976-978)CTC>ATC	p.L326I	FBP1_uc010mrl.2_Missense_Mutation_p.L326I	NM_000507	NP_000498	P09467	F16P1_HUMAN	fructose-1,6-bisphosphatase 1	326					gluconeogenesis	cytosol	fructose 1,6-bisphosphate 1-phosphatase activity|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding|metal ion binding				0		Acute lymphoblastic leukemia(62;0.136)			Adenosine monophosphate(DB00131)	AGGAACTCGAGCACGTCGTCG	0.587		NaN									OREG0019330	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	4.96729e-08	0.049695	5.18431e-08	18	20									
PTCH1	5727	broad.mit.edu	37	9	98240410	98240410	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr9:98240410G>A	uc004avk.3	-	9	1462	c.1274C>T	c.(1273-1275)ACG>ATG	p.T425M	PTCH1_uc010mro.2_Missense_Mutation_p.T274M|PTCH1_uc010mrp.2_Missense_Mutation_p.T274M|PTCH1_uc010mrq.2_Missense_Mutation_p.T274M|PTCH1_uc004avl.3_Missense_Mutation_p.T274M|PTCH1_uc010mrr.2_Missense_Mutation_p.T359M|PTCH1_uc004avm.3_Missense_Mutation_p.T424M|PTCH1_uc010mrs.1_Missense_Mutation_p.T145M	NM_000264	NP_000255	Q13635	PTC1_HUMAN	patched isoform L	425	Extracellular (Potential).				embryonic limb morphogenesis|negative regulation of multicellular organism growth|protein processing|regulation of smoothened signaling pathway|smoothened signaling pathway	integral to plasma membrane	hedgehog receptor activity			skin(242)|central_nervous_system(72)|bone(33)|upper_aerodigestive_tract(11)|lung(6)|large_intestine(4)|breast(4)|oesophagus(3)|ovary(3)|vulva(1)	379		Medulloblastoma(1;7.87e-06)|all_neural(1;0.000555)|Acute lymphoblastic leukemia(62;0.136)				GTCCAGGGTCGTGGTGGTGAA	0.532		NaN							Basal_Cell_Nevus_syndrome				0	0	0	0.01892	0	26	68									
PAPPA	5069	broad.mit.edu	37	9	119065048	119065048	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr9:119065048G>A	uc004bjn.2	+	10	3347	c.2966G>A	c.(2965-2967)CGG>CAG	p.R989Q	PAPPA_uc011lxp.1_Missense_Mutation_p.R684Q|PAPPA_uc011lxq.1_Missense_Mutation_p.R364Q	NM_002581	NP_002572	Q13219	PAPP1_HUMAN	pregnancy-associated plasma protein A	989					cell differentiation|female pregnancy	cytoplasm|extracellular region|membrane	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(4)|pancreas(1)	9						GAACCCAGCCGGTGCTATTTC	0.453		NaN											0	0	0	0.043863	0	18	45									
SH2D3C	10044	broad.mit.edu	37	9	130536733	130536733	+	Missense_Mutation	SNP	G	G	C			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr9:130536733G>C	uc004bsc.2	-	2	193	c.51C>G	c.(49-51)TTC>TTG	p.F17L	SH2D3C_uc004bsd.1_5'UTR	NM_170600	NP_733745	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C isoform a	17					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			ovary(1)	1						CAAAGCCCTTGAACTTGAAGA	0.473		NaN											0	0	0	0.014758	0	5	48									
NOTCH1	4851	broad.mit.edu	37	9	139399556	139399556	+	Silent	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr9:139399556G>A	uc004chz.2	-	26	4587	c.4587C>T	c.(4585-4587)AAC>AAT	p.N1529N	NOTCH1_uc004cia.1_Silent_p.N759N	NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1529	Extracellular (Potential).|LNR 2.				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CGTACAGGGGGCTGTGGGGGG	0.731		NaN	T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			0	0	0	0.038395	0	16	18									
BMX	660	broad.mit.edu	37	X	15552335	15552335	+	Missense_Mutation	SNP	T	T	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chrX:15552335T>A	uc004cww.2	+	12	1208	c.1020T>A	c.(1018-1020)AAT>AAA	p.N340K	BMX_uc004cwx.3_Missense_Mutation_p.N340K|BMX_uc004cwy.3_Missense_Mutation_p.N340K	NM_203281	NP_975010	P51813	BMX_HUMAN	BMX non-receptor tyrosine kinase	340	SH2.				cellular component disassembly involved in apoptosis|intracellular signal transduction|mesoderm development	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			lung(3)|ovary(2)	5	Hepatocellular(33;0.183)					CTGTTACTAGTGATAAAAAAG	0.303		NaN											0	0	0	0.028581	0	16	54									
KLHL34	257240	broad.mit.edu	37	X	21675187	21675187	+	Silent	SNP	A	A	G			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chrX:21675187A>G	uc004czz.1	-	1	1262	c.720T>C	c.(718-720)TCT>TCC	p.S240S		NM_153270	NP_695002	Q8N239	KLH34_HUMAN	kelch-like 34	240										ovary(1)	1						GCACGAGGCCAGAGCCCGAGT	0.672		NaN											0	0	0	0.021553	0	6	19									
KLHL15	80311	broad.mit.edu	37	X	24024257	24024257	+	Missense_Mutation	SNP	T	T	C			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chrX:24024257T>C	uc004dba.3	-	3	810	c.554A>G	c.(553-555)GAT>GGT	p.D185G		NM_030624	NP_085127	Q96M94	KLH15_HUMAN	kelch-like 15	185	BACK.									ovary(1)|breast(1)	2						ATGATCATTATCCAAGTAAGA	0.478		NaN											0	0	0	0.048971	0	79	17									
UBQLN2	29978	broad.mit.edu	37	X	56591910	56591910	+	Missense_Mutation	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chrX:56591910G>A	uc004dus.2	+	1	1839	c.1604G>A	c.(1603-1605)GGG>GAG	p.G535E	UBQLN2_uc011moq.1_Intron	NM_013444	NP_038472	Q9UHD9	UBQL2_HUMAN	ubiquilin 2	535						cytoplasm|nucleus|plasma membrane	binding			ovary(1)|skin(1)	2						GGCCCCACGGGGCCTACTGTG	0.622		NaN											0	0	0	0.021553	0	5	1									
STAG2	10735	broad.mit.edu	37	X	123196751	123196751	+	Splice_Site	SNP	G	G	A			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chrX:123196751G>A	uc004etz.3	+	17	1978	c.1639_splice	c.e17-1	p.V547_splice	STAG2_uc004eua.2_Splice_Site_p.V547_splice|STAG2_uc004eub.2_Splice_Site_p.V547_splice|STAG2_uc004euc.2_Splice_Site_p.V547_splice|STAG2_uc004eud.2_Splice_Site_p.V547_splice|STAG2_uc004eue.2_Splice_Site_p.V547_splice	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b						cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						TGTTCCTTTAGGTGCTTACAG	0.343		NaN											0	0	0	0.037714	0	29	8									
C11orf9	745	broad.mit.edu	37	11	61536739	61536739	+	Frame_Shift_Del	DEL	C	C	-			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr11:61536739delC	uc001nsc.1	+	4	502	c.406delC	c.(406-408)CCGfs	p.P136fs	C11orf9_uc001nse.1_Frame_Shift_Del_p.P127fs	NM_001127392	NP_001120864	Q9Y2G1	MRF_HUMAN	myelin gene regulatory factor isoform 2	136	Pro-rich.				central nervous system myelination|positive regulation of myelination|positive regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						CAGCACACTGCCGGACTCTCC	0.682		NaN											NaN	NaN	NaN	NaN	NaN	5	4	---	---							
PLEKHA9	51054	broad.mit.edu	37	12	45567306	45567306	+	Frame_Shift_Del	DEL	A	A	-			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr12:45567306delA	uc001rom.1	-	3	1380	c.843delT	c.(841-843)GTTfs	p.V281fs	PLEKHA9_uc009zke.2_Frame_Shift_Del_p.V281fs	NM_015899	NP_056983			pleckstrin homology domain containing, family A												0	Lung SC(27;0.192)|Renal(347;0.236)			GBM - Glioblastoma multiforme(48;0.173)		CTGAGTTCCTAACCTGGGCTA	0.418		NaN											NaN	NaN	NaN	NaN	NaN	33	57	---	---							
MLL2	8085	broad.mit.edu	37	12	49425478	49425478	+	Frame_Shift_Del	DEL	G	G	-			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08			G	-	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr12:49425478delG	uc001rta.3	-	39	13010	c.13010delC	c.(13009-13011)CCTfs	p.P4337fs		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	4337	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						ATGGGTGGGAGGGAGCTGGGC	0.617		NaN	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			NaN	NaN	NaN	NaN	NaN	17	16	---	---							
FAM186B	84070	broad.mit.edu	37	12	49994518	49994518	+	Frame_Shift_Del	DEL	C	C	-			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr12:49994518delC	uc001ruo.2	-	4	1078	c.905delG	c.(904-906)GGAfs	p.G302fs	FAM186B_uc010smk.1_Frame_Shift_Del_p.G212fs	NM_032130	NP_115506	Q8IYM0	F186B_HUMAN	hypothetical protein LOC84070	302						protein complex				ovary(1)	1						ATGGTACCTTCCCCCTAAGAT	0.542		NaN											NaN	NaN	NaN	NaN	NaN	20	226	---	---							
MBD1	4152	broad.mit.edu	37	18	47802020	47802020	+	Frame_Shift_Del	DEL	G	G	-			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr18:47802020delG	uc010dow.1	-	8	1179	c.742delC	c.(742-744)CGCfs	p.R248fs	MBD1_uc002lef.2_Frame_Shift_Del_p.R30fs|MBD1_uc002leg.2_Frame_Shift_Del_p.R199fs|MBD1_uc010xdi.1_Frame_Shift_Del_p.R274fs|MBD1_uc002leh.3_Frame_Shift_Del_p.R248fs|MBD1_uc002len.2_Frame_Shift_Del_p.R248fs|MBD1_uc002lei.3_Frame_Shift_Del_p.R248fs|MBD1_uc002lej.3_Frame_Shift_Del_p.R248fs|MBD1_uc002lek.3_Frame_Shift_Del_p.R199fs|MBD1_uc002lel.3_Frame_Shift_Del_p.R248fs|MBD1_uc002lem.3_Frame_Shift_Del_p.R248fs|MBD1_uc010xdj.1_Frame_Shift_Del_p.R248fs|MBD1_uc010xdk.1_Frame_Shift_Del_p.R248fs|MBD1_uc010dox.1_Frame_Shift_Del_p.R248fs|MBD1_uc002leo.2_Frame_Shift_Del_p.R248fs	NM_015846	NP_056671	Q9UIS9	MBD1_HUMAN	methyl-CpG binding domain protein 1 isoform 1	248	CXXC-type 2.				negative regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|nuclear speck	methyl-CpG binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2						AGACCAGGGCGGGGAGGGCGA	0.632		NaN											NaN	NaN	NaN	NaN	NaN	28	49	---	---							
NEB	4703	broad.mit.edu	37	2	152420419	152420419	+	Frame_Shift_Del	DEL	C	C	-			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr2:152420419delC	uc010fnx.2	-	90	13585	c.13394delG	c.(13393-13395)GGCfs	p.G4465fs	NEB_uc002txr.2_Frame_Shift_Del_p.G888fs	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	4465	Nebulin 122.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		GGCCTTGGTGCCCTCCCACGC	0.443		NaN											NaN	NaN	NaN	NaN	NaN	10	19	---	---							
PGAP1	80055	broad.mit.edu	37	2	197781295	197781295	+	Frame_Shift_Del	DEL	T	T	-			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr2:197781295delT	uc002utw.2	-	3	438	c.324delA	c.(322-324)GCAfs	p.A108fs	PGAP1_uc002utx.2_5'UTR|PGAP1_uc002uty.1_Frame_Shift_Del_p.A108fs|PGAP1_uc010zgv.1_RNA|PGAP1_uc010fsj.2_5'UTR	NM_024989	NP_079265	Q75T13	PGAP1_HUMAN	GPI deacylase	108	Lumenal (Potential).				attachment of GPI anchor to protein|C-terminal protein lipidation|intracellular protein transport|myo-inositol transport	integral to membrane|intrinsic to endoplasmic reticulum membrane	nuclease activity|phosphoric ester hydrolase activity			ovary(3)|central_nervous_system(1)	4						CTTTTCTAAGTGCAATGGAGC	0.378		NaN											NaN	NaN	NaN	NaN	NaN	28	26	---	---							
COL4A4	1286	broad.mit.edu	37	2	227906897	227906897	+	Frame_Shift_Del	DEL	C	C	-			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr2:227906897delC	uc010zlt.1	-	37	4126	c.3472delG	c.(3472-3474)GATfs	p.D1158fs		NM_000092	NP_000083	P53420	CO4A4_HUMAN	alpha 4 type IV collagen precursor	1158	Triple-helical region.				axon guidance|glomerular basement membrane development	basal lamina|collagen type IV	extracellular matrix structural constituent|protein binding			ovary(5)|central_nervous_system(3)|pancreas(1)|breast(1)|skin(1)	11		Renal(207;0.00844)|all_lung(227;0.0187)|Lung NSC(271;0.0879)|all_hematologic(139;0.21)|Esophageal squamous(248;0.242)		Epithelial(121;6.7e-11)|all cancers(144;5.39e-08)|Lung(261;0.0132)|LUSC - Lung squamous cell carcinoma(224;0.0181)		ATCCCTGGATCCCCCTGGAGG	0.542		NaN											NaN	NaN	NaN	NaN	NaN	41	98	---	---							
MCTP1	79772	broad.mit.edu	37	5	94207113	94207113	+	Frame_Shift_Del	DEL	T	T	-			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr5:94207113delT	uc003kkx.2	-	14	2046	c.2046delA	c.(2044-2046)AAAfs	p.K682fs	MCTP1_uc003kkv.2_Frame_Shift_Del_p.K461fs|MCTP1_uc003kkw.2_Frame_Shift_Del_p.K415fs|MCTP1_uc003kkz.2_Frame_Shift_Del_p.K343fs|MCTP1_uc003kku.2_Frame_Shift_Del_p.K198fs	NM_024717	NP_078993	Q6DN14	MCTP1_HUMAN	multiple C2 domains, transmembrane 1 isoform L	682	C2 3.				calcium-mediated signaling	integral to membrane|membrane fraction	calcium ion binding			ovary(2)	2		all_cancers(142;1.68e-05)|all_epithelial(76;1.51e-07)|all_lung(232;0.0167)|Lung NSC(167;0.0207)|Ovarian(225;0.0218)|Colorectal(57;0.207)		all cancers(79;9.1e-17)		AATGGATATCTTTAATGTTGC	0.338		NaN											NaN	NaN	NaN	NaN	NaN	25	36	---	---							
DNAH8	1769	broad.mit.edu	37	6	38810224	38810224	+	Frame_Shift_Del	DEL	T	T	-			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr6:38810224delT	uc003ooe.1	+	32	4496	c.3896delT	c.(3895-3897)CTTfs	p.L1299fs		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						TATGAAATACTTTGGGGAGAT	0.343		NaN											NaN	NaN	NaN	NaN	NaN	30	72	---	---							
TRERF1	55809	broad.mit.edu	37	6	42236492	42236492	+	Frame_Shift_Del	DEL	C	C	-			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr6:42236492delC	uc003osd.2	-	5	1400	c.837delG	c.(835-837)GGGfs	p.G279fs	TRERF1_uc011duq.1_Frame_Shift_Del_p.G279fs|TRERF1_uc003osb.2_Frame_Shift_Del_p.G118fs|TRERF1_uc003osc.2_Frame_Shift_Del_p.G118fs|TRERF1_uc003ose.2_Frame_Shift_Del_p.G279fs	NM_033502	NP_277037	Q96PN7	TREF1_HUMAN	transcriptional regulating factor 1	279	Gln-rich.				cholesterol catabolic process|homeostatic process|multicellular organismal development|positive regulation of transcription, DNA-dependent|regulation of hormone biosynthetic process|steroid biosynthetic process	nucleus	DNA bending activity|ligand-dependent nuclear receptor transcription coactivator activity|RNA polymerase II transcription cofactor activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|zinc ion binding			ovary(3)|pancreas(1)|skin(1)	5	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			TACGCTGTTGCCCGGCTTGCT	0.512		NaN											NaN	NaN	NaN	NaN	NaN	64	118	---	---							
SLC4A2	6522	broad.mit.edu	37	7	150761698	150761698	+	Frame_Shift_Del	DEL	C	C	-			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr7:150761698delC	uc003wit.3	+	4	559	c.303delC	c.(301-303)GGCfs	p.G101fs	SLC4A2_uc011kve.1_Frame_Shift_Del_p.G92fs|SLC4A2_uc003wiu.3_Frame_Shift_Del_p.G87fs	NM_003040	NP_003031	P04920	B3A2_HUMAN	solute carrier family 4, anion exchanger, member	101	Cytoplasmic (Potential).|Pro-rich.				bicarbonate transport	integral to membrane|membrane fraction	inorganic anion exchanger activity				0			OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		CACCCCAGGGCCCAGGACGGA	0.682		NaN											NaN	NaN	NaN	NaN	NaN	55	75	---	---							
MLL3	58508	broad.mit.edu	37	7	151877847	151877847	+	Frame_Shift_Del	DEL	A	A	-			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08			A	-	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr7:151877847delA	uc003wla.2	-	36	7317	c.7098delT	c.(7096-7098)GATfs	p.D2366fs	MLL3_uc003wkz.2_Frame_Shift_Del_p.D1427fs|MLL3_uc003wky.2_5'Flank	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	2366					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TATTCTGTGTATCAGTTACTC	0.428		NaN	N		medulloblastoma								NaN	NaN	NaN	NaN	NaN	40	28	---	---							
C8orf73	642475	broad.mit.edu	37	8	144650796	144650796	+	Frame_Shift_Del	DEL	G	G	-			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr8:144650796delG	uc010mff.2	-	10	1614	c.1570delC	c.(1570-1572)CTGfs	p.L524fs	C8orf73_uc010mfg.1_Frame_Shift_Del_p.P536fs	NM_001100878	NP_001094348	A6NGR9	CH073_HUMAN	hypothetical protein LOC642475	524	Leu-rich.						binding			ovary(1)	1	all_cancers(97;6.49e-11)|all_epithelial(106;4.73e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.014)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.146)			AGCTTCCGCAgggggccgcgg	0.532		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---							
NOTCH1	4851	broad.mit.edu	37	9	139395013	139395025	+	Frame_Shift_Del	DEL	ACCTTGTGCGTCG	ACCTTGTGCGTCG	-			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chr9:139395013_139395025delACCTTGTGCGTCG	uc004chz.2	-	31	5913_5925	c.5913_5925delCGACGCACAAGGT	c.(5911-5925)GCCGACGCACAAGGTfs	p.A1971fs		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	1971_1975	ANK 2.|Cytoplasmic (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		CCTGGAAGACACCTTGTGCGTCGGCAGACACAG	0.676		NaN	T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			NaN	NaN	NaN	NaN	NaN	36	120	---	---							
DDX3X	1654	broad.mit.edu	37	X	41205816	41205818	+	In_Frame_Del	DEL	CAA	CAA	-			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chrX:41205816_41205818delCAA	uc004dfe.2	+	14	2411_2413	c.1556_1558delCAA	c.(1555-1560)CCAAGT>CGT	p.519_520PS>R	DDX3X_uc004dff.2_In_Frame_Del_p.519_520PS>R|DDX3X_uc011mkq.1_In_Frame_Del_p.503_504PS>R|DDX3X_uc011mkr.1_Intron|DDX3X_uc011mks.1_Intron|DDX3X_uc004dfg.2_RNA|DDX3X_uc011mkt.1_RNA	NM_001356	NP_001347	O00571	DDX3X_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3	519_520	Helicase C-terminal.				interspecies interaction between organisms	cytoplasm|nuclear speck	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding|RNA binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6						TTTGACTTGCCAAGTGATATTGA	0.36		NaN								HNSCC(61;0.18)			NaN	NaN	NaN	NaN	NaN	10	76	---	---							
PCDH19	57526	broad.mit.edu	37	X	99661761	99661762	+	Frame_Shift_Ins	INS	-	-	G			TCGA-E7-A3Y1-01A-11D-A22Z-08	TCGA-E7-A3Y1-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	afb4bcde-56d9-42cb-b89d-9fc8559b3fa3	bf2c0de5-987d-420b-b60a-96b70ec19a41	g.chrX:99661761_99661762insG	uc010nmz.2	-	1	3510_3511	c.1834_1835insC	c.(1834-1836)CGCfs	p.R612fs	PCDH19_uc004efw.3_Frame_Shift_Ins_p.R612fs|PCDH19_uc004efx.3_Frame_Shift_Ins_p.R612fs	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	612	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						AAAGAAGCCGCGGTCGCCCTCG	0.564		NaN											NaN	NaN	NaN	NaN	NaN	42	11	---	---							
