Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
SAMD11	148398	broad.mit.edu	37	1	865617	865617	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:865617C>G	uc001abw.1	+	3	235	c.155C>G	c.(154-156)TCT>TGT	p.S52C	SAMD11_uc001abv.1_Missense_Mutation_p.S52C	NM_152486	NP_689699	Q96NU1	SAM11_HUMAN	sterile alpha motif domain containing 11	52						nucleus					0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00459)|Epithelial(90;1.74e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.93e-23)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|BRCA - Breast invasive adenocarcinoma(365;0.000472)|Kidney(185;0.0023)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.199)		CCCAGCTTCTCTGCCAGCGAT	0.597		NaN											0	0	0	0.001984	0	6	20									
TAS1R1	80835	broad.mit.edu	37	1	6639125	6639125	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:6639125C>G	uc001ant.2	+	6	2007	c.2007C>G	c.(2005-2007)TTC>TTG	p.F669L	TAS1R1_uc001anu.2_Missense_Mutation_p.F415L|TAS1R1_uc001anv.2_Intron|TAS1R1_uc001anw.2_3'UTR|ZBTB48_uc009vmc.1_5'Flank|ZBTB48_uc001anx.2_5'Flank|ZBTB48_uc009vmd.1_5'Flank	NM_138697	NP_619642	Q7RTX1	TS1R1_HUMAN	sweet taste receptor T1r isoform b	669	Cytoplasmic (Potential).				sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		TACCTACATTCTACCACGCCT	0.522		NaN											0	0	0	0.009718	0	37	83									
TAS1R1	80835	broad.mit.edu	37	1	6639332	6639332	+	Silent	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:6639332C>T	uc001ant.2	+	6	2214	c.2214C>T	c.(2212-2214)CTC>CTT	p.L738L	TAS1R1_uc001anu.2_Silent_p.L484L|TAS1R1_uc001anv.2_Intron|TAS1R1_uc001anw.2_3'UTR|ZBTB48_uc009vmc.1_5'Flank|ZBTB48_uc001anx.2_5'Flank|ZBTB48_uc009vmd.1_5'Flank	NM_138697	NP_619642	Q7RTX1	TS1R1_HUMAN	sweet taste receptor T1r isoform b	738	Helical; Name=5; (Potential).				sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		ATGGCCTCCTCTCCATCAGTG	0.542		NaN											0	0	0	0.006122	0	18	48									
TAS1R1	80835	broad.mit.edu	37	1	6639338	6639338	+	Silent	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:6639338C>T	uc001ant.2	+	6	2220	c.2220C>T	c.(2218-2220)ATC>ATT	p.I740I	TAS1R1_uc001anu.2_Silent_p.I486I|TAS1R1_uc001anv.2_Intron|TAS1R1_uc001anw.2_3'UTR|ZBTB48_uc009vmc.1_5'Flank|ZBTB48_uc001anx.2_5'Flank|ZBTB48_uc009vmd.1_5'Flank	NM_138697	NP_619642	Q7RTX1	TS1R1_HUMAN	sweet taste receptor T1r isoform b	740	Helical; Name=5; (Potential).				sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	Ovarian(185;0.0212)|all_lung(157;0.154)	all_cancers(23;8.73e-34)|all_epithelial(116;9.26e-22)|all_lung(118;7.57e-07)|Lung NSC(185;4.26e-06)|Breast(487;0.000353)|Renal(390;0.0007)|Colorectal(325;0.00104)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0443)		Colorectal(212;1.29e-07)|COAD - Colon adenocarcinoma(227;1.33e-05)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000896)|BRCA - Breast invasive adenocarcinoma(365;0.00108)|STAD - Stomach adenocarcinoma(132;0.0167)|READ - Rectum adenocarcinoma(331;0.0642)		TCCTCTCCATCAGTGCCTTTG	0.547		NaN											0	0	0	0.00499	0	18	52									
PTCHD2	57540	broad.mit.edu	37	1	11561856	11561856	+	Silent	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:11561856G>A	uc001ash.3	+	2	945	c.807G>A	c.(805-807)ACG>ACA	p.T269T	PTCHD2_uc001asi.1_Silent_p.T269T	NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	269	Extracellular (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		ACACTCAGACGCACGCGCACT	0.677		NaN											0	0	0	0.001368	0	12	20									
LHX8	431707	broad.mit.edu	37	1	75609605	75609605	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:75609605G>A	uc001dgo.2	+	7	1350	c.686G>A	c.(685-687)CGG>CAG	p.R229Q	LHX8_uc001dgq.2_Missense_Mutation_p.R168Q	NM_001001933	NP_001001933	Q68G74	LHX8_HUMAN	LIM homeobox 8	229	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)	3						AAAAGAGCTCGGACCAGCTTT	0.403		NaN											0	0	0	0.001855	0	14	37									
ODF2L	57489	broad.mit.edu	37	1	86842058	86842058	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:86842058A>G	uc001dll.1	-	8	1008	c.668T>C	c.(667-669)ATG>ACG	p.M223T	ODF2L_uc001dlm.1_Missense_Mutation_p.M223T|ODF2L_uc001dln.2_Missense_Mutation_p.M223T|ODF2L_uc001dlo.2_Missense_Mutation_p.M92T|ODF2L_uc001dlp.2_Missense_Mutation_p.M223T|ODF2L_uc010osg.1_Missense_Mutation_p.M223T|ODF2L_uc001dlq.1_Missense_Mutation_p.M53T|ODF2L_uc009wcr.1_Missense_Mutation_p.M92T	NM_020729	NP_065780	Q9ULJ1	ODF2L_HUMAN	outer dense fiber of sperm tails 2-like isoform	223						centrosome				ovary(1)	1				all cancers(265;0.0313)|Epithelial(280;0.0611)		ATTCTTATTCATTCTTGATTG	0.313		NaN											0	0	0	0.001368	0	11	25									
KIAA1324	57535	broad.mit.edu	37	1	109732234	109732234	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:109732234C>T	uc001dwq.2	+	12	1505	c.1369C>T	c.(1369-1371)CAC>TAC	p.H457Y	KIAA1324_uc009wex.1_Missense_Mutation_p.H407Y|KIAA1324_uc009wey.2_Missense_Mutation_p.H370Y|KIAA1324_uc010ovg.1_Missense_Mutation_p.H355Y|KIAA1324_uc001dwr.2_Missense_Mutation_p.H107Y	NM_020775	NP_065826	Q6UXG2	K1324_HUMAN	hypothetical protein LOC57535 precursor	457	Extracellular (Potential).				macroautophagy|positive regulation of vacuole organization|regulation of apoptosis	integral to plasma membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)|breast(1)|skin(1)	5		all_epithelial(167;0.000102)|all_lung(203;0.000323)|Lung NSC(277;0.00063)		Colorectal(144;0.0188)|Lung(183;0.0527)|COAD - Colon adenocarcinoma(174;0.14)|Epithelial(280;0.21)|all cancers(265;0.249)		GGCTGGTGATCACATTTACAC	0.517		NaN											0	0	0	0.00499	0	15	21									
DDX20	11218	broad.mit.edu	37	1	112308378	112308378	+	Silent	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:112308378G>C	uc001ebs.2	+	11	1689	c.1332G>C	c.(1330-1332)CTG>CTC	p.L444L	DDX20_uc010owf.1_Silent_p.L206L|DDX20_uc001ebt.2_Silent_p.L52L	NM_007204	NP_009135	Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	444	Helicase C-terminal.				assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			lung(1)|kidney(1)	2		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CTTCTGGTCTGATGGAAGAAT	0.353		NaN											0	0	0	0.004878	0	38	74									
BCL9	607	broad.mit.edu	37	1	147090999	147090999	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:147090999G>C	uc001epq.2	+	8	1778	c.1038G>C	c.(1036-1038)GAG>GAC	p.E346D	BCL9_uc010ozr.1_Missense_Mutation_p.E272D	NM_004326	NP_004317	O00512	BCL9_HUMAN	B-cell CLL/lymphoma 9	346	Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding			ovary(2)|large_intestine(2)|breast(1)|skin(1)	6	all_hematologic(923;0.115)					CACTGGGAGAGAATCCCGATG	0.577		NaN	T	IGH@|IGL@	B-ALL								0	0	0	0.00361	0	74	167									
HAX1	10456	broad.mit.edu	37	1	154245817	154245817	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:154245817G>A	uc001fes.2	+	2	220	c.59G>A	c.(58-60)AGA>AAA	p.R20K	HAX1_uc001fet.2_Intron|HAX1_uc010peo.1_Missense_Mutation_p.R20K|HAX1_uc009wou.2_5'UTR|HAX1_uc009wov.2_5'UTR	NM_006118	NP_006109	O00165	HAX1_HUMAN	HCLS1 associated protein X-1 isoform a	20	Required for localization in mitochondria (By similarity).					actin cytoskeleton|cytoplasmic membrane-bounded vesicle|lamellipodium|mitochondrion|nuclear membrane|sarcoplasmic reticulum|soluble fraction	interleukin-1 binding|protein N-terminus binding				0	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CTCAGCCACAGAGATCCCTTT	0.493		NaN							Kostmann_syndrome				0	0	0	0.009535	0	31	114									
C1orf114	57821	broad.mit.edu	37	1	169390861	169390861	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:169390861C>G	uc001gga.1	-	3	976	c.808G>C	c.(808-810)GAA>CAA	p.E270Q	C1orf114_uc001gfz.1_Missense_Mutation_p.E270Q|C1orf114_uc009wvq.1_Missense_Mutation_p.E270Q|C1orf114_uc001ggb.2_Missense_Mutation_p.E270Q|C1orf114_uc001ggc.1_Missense_Mutation_p.E270Q	NM_021179	NP_067002	Q5TID7	CA114_HUMAN	hypothetical protein LOC57821	270											0	all_hematologic(923;0.208)					GTAGAATCTTCTTTCTTGGTG	0.468		NaN											0	0	0	0.00361	0	50	170									
METTL13	51603	broad.mit.edu	37	1	171753057	171753057	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:171753057C>T	uc001ghz.2	+	2	678	c.331C>T	c.(331-333)CCT>TCT	p.P111S	METTL13_uc001gia.2_Missense_Mutation_p.P25S|METTL13_uc001gib.2_Missense_Mutation_p.P111S|METTL13_uc010pml.1_Missense_Mutation_p.P110S	NM_015935	NP_057019	Q8N6R0	MTL13_HUMAN	CGI-01 protein isoform 1	111							methyltransferase activity|protein binding			kidney(1)	1						GATGGAGTTTCCTGATGCCTC	0.527		NaN											0	0	0	0.008871	0	21	75									
RC3H1	149041	broad.mit.edu	37	1	173930937	173930937	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:173930937C>G	uc001gju.3	-	11	2215	c.2128G>C	c.(2128-2130)GAA>CAA	p.E710Q	RC3H1_uc010pms.1_Missense_Mutation_p.E710Q|RC3H1_uc001gjv.2_Missense_Mutation_p.E710Q|RC3H1_uc010pmt.1_Missense_Mutation_p.E710Q	NM_172071	NP_742068	Q5TC82	RC3H1_HUMAN	roquin	710	Pro-rich.				cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						TGGTATCTTTCTCTGGATTCT	0.438		NaN											0	0	0	0.00361	0	59	196									
LAMC1	3915	broad.mit.edu	37	1	183096408	183096408	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:183096408G>A	uc001gpy.3	+	17	3249	c.2992G>A	c.(2992-2994)GAT>AAT	p.D998N		NM_002293	NP_002284	P11047	LAMC1_HUMAN	laminin, gamma 1 precursor	998	Laminin EGF-like 11.				axon guidance|cell migration|endoderm development|extracellular matrix disassembly|hemidesmosome assembly|positive regulation of epithelial cell proliferation|protein complex assembly|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	extracellular matrix structural constituent			ovary(3)|large_intestine(1)|kidney(1)	5					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	GTGCAAAGATGATGGTCGCTG	0.433		NaN											0	0	0	0.00499	0	18	54									
C1orf26	54823	broad.mit.edu	37	1	185130013	185130013	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:185130013C>G	uc001grg.3	+	2	154	c.40C>G	c.(40-42)CAG>GAG	p.Q14E	C1orf26_uc001grh.3_Missense_Mutation_p.Q14E	NM_001105518	NP_001098988	Q5T5J6	SWT1_HUMAN	hypothetical protein LOC54823	14											0						AGAGACATCTCAGAGGAAAGA	0.323		NaN											0	0	0	0.008871	0	15	51									
CHIT1	1118	broad.mit.edu	37	1	203192777	203192777	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:203192777A>T	uc001gzn.2	-	5	422	c.326T>A	c.(325-327)ATG>AAG	p.M109K	FMOD_uc010pqi.1_Intron|CHIT1_uc001gzm.1_RNA|CHIT1_uc009xal.1_5'Flank|CHIT1_uc009xam.1_RNA|CHIT1_uc009xan.1_RNA|CHIT1_uc001gzo.2_Missense_Mutation_p.M100K	NM_003465	NP_003456	Q13231	CHIT1_HUMAN	chitotriosidase precursor	109					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity				0						CGTGGCTACCATATCTGTGAA	0.542		NaN											0	0	0	0.00361	0	51	180									
REN	5972	broad.mit.edu	37	1	204125342	204125342	+	Silent	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:204125342G>A	uc001haq.2	-	8	968	c.924C>T	c.(922-924)CTC>CTT	p.L308L		NM_000537	NP_000528	P00797	RENI_HUMAN	renin preproprotein	308					angiotensin maturation|regulation of MAPKKK cascade	extracellular space|membrane	aspartic-type endopeptidase activity			skin(3)|central_nervous_system(1)	4	all_cancers(21;0.00965)|Breast(84;0.116)|all_epithelial(62;0.157)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.109)		Aliskiren(DB01258)|Remikiren(DB00212)	AGGCCTCCATGAGCTTCTCTA	0.562		NaN											0	0	0	0.00361	0	100	357									
DISP1	84976	broad.mit.edu	37	1	223116319	223116319	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:223116319C>T	uc001hnu.1	+	2	301	c.154C>T	c.(154-156)CCA>TCA	p.P52S		NM_032890	NP_116279	Q96F81	DISP1_HUMAN	dispatched A	52					diaphragm development|protein homotrimerization|regulation of protein secretion|smoothened signaling pathway	basolateral plasma membrane|integral to membrane	hedgehog receptor activity|peptide transporter activity				0				GBM - Glioblastoma multiforme(131;0.102)		AAAAGTGAGTCCAAATGGATG	0.512		NaN											0	0	0	0.001882	0	22	78									
C1orf35	79169	broad.mit.edu	37	1	228288840	228288840	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:228288840C>T	uc001hrx.2	-	8	878	c.784G>A	c.(784-786)GAG>AAG	p.E262K	C1orf35_uc009xew.2_RNA	NM_024319	NP_077295	Q9BU76	MMTA2_HUMAN	hypothetical protein LOC79169	262				E -> K (in Ref. 1; AAN15215).							0		Prostate(94;0.0488)				CATCAGGCCTCAGAGCCTCTG	0.627		NaN											0	0	0	0.002522	0	44	108									
OBSCN	84033	broad.mit.edu	37	1	228556048	228556048	+	Silent	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:228556048C>T	uc009xez.1	+	88	19742	c.19698C>T	c.(19696-19698)GTC>GTT	p.V6566V	OBSCN_uc001hsr.1_Silent_p.V1195V	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	6566	Protein kinase 1.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				AGGTCAAGGTCTACATCCAGC	0.622		NaN											0	0	0	0.009096	0	4	9									
EXOC8	149371	broad.mit.edu	37	1	231473425	231473425	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:231473425C>G	uc001huq.2	-	1	154	c.67G>C	c.(67-69)GAG>CAG	p.E23Q	C1orf124_uc001hur.2_5'Flank|C1orf124_uc001hus.2_5'Flank|C1orf124_uc001hut.2_5'Flank	NM_175876	NP_787072	Q8IYI6	EXOC8_HUMAN	exocyst complex 84-kDa subunit	23					exocytosis|protein transport	growth cone|nucleus	protein binding			skin(1)	1	Breast(184;0.0871)	all_cancers(173;0.151)|Prostate(94;0.183)				AGCCGCGCCTCAAAACCCCCT	0.667		NaN											0	0	0	0.004878	0	35	109									
GAD2	2572	broad.mit.edu	37	10	26558051	26558051	+	Silent	SNP	G	G	T	rs149629039	byFrequency	TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr10:26558051G>T	uc001isp.2	+	9	1427	c.924G>T	c.(922-924)GGG>GGT	p.G308G	GAD2_uc001isq.2_Silent_p.G308G	NM_001134366	NP_001127838	Q05329	DCE2_HUMAN	glutamate decarboxylase 2	308					glutamate decarboxylation to succinate|neurotransmitter biosynthetic process|neurotransmitter secretion	cell junction|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|cytosol|Golgi membrane|presynaptic membrane	glutamate decarboxylase activity|protein binding|pyridoxal phosphate binding			central_nervous_system(1)|skin(1)	2					L-Glutamic Acid(DB00142)	CTTCCAGAGGGAAAATGATTC	0.403		NaN											1	0	9.16793e-09	0.00499	9.42801e-09	17	42									
ARMC4	55130	broad.mit.edu	37	10	28196616	28196616	+	Silent	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr10:28196616G>C	uc009xky.2	-	17	2684	c.2586C>G	c.(2584-2586)CTC>CTG	p.L862L	ARMC4_uc010qds.1_Silent_p.L387L|ARMC4_uc010qdt.1_Silent_p.L554L|ARMC4_uc001itz.2_Silent_p.L862L	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	862	ARM 6.						binding			ovary(4)|skin(2)	6						TGCATGGACAGAGTGCCCATG	0.448		NaN											0	0	0	0.001882	0	21	37									
ANK3	288	broad.mit.edu	37	10	61835134	61835134	+	Silent	SNP	T	T	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr10:61835134T>A	uc001jky.2	-	37	5697	c.5505A>T	c.(5503-5505)GCA>GCT	p.A1835A	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	1835	Ser-rich.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						GTTTCTTTAATGCTGGTTCTG	0.413		NaN											0	0	0	0.00361	0	53	150									
CDH23	64072	broad.mit.edu	37	10	73572328	73572328	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr10:73572328G>C	uc001jrx.3	+	65	9849	c.9472G>C	c.(9472-9474)GAG>CAG	p.E3158Q	CDH23_uc001jsg.3_Missense_Mutation_p.E918Q|CDH23_uc001jsh.3_Missense_Mutation_p.E918Q|CDH23_uc001jsi.3_Missense_Mutation_p.E918Q|CDH23_uc001jsj.3_Missense_Mutation_p.E55Q|CDH23_uc010qjr.1_Missense_Mutation_p.E55Q	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	3158	Cytoplasmic (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						GAACCTGAGTGAGATCGCCGA	0.642		NaN											0	0	0	0.00623	0	39	72									
ENTPD7	57089	broad.mit.edu	37	10	101460767	101460767	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr10:101460767G>A	uc001kqa.3	+	11	1551	c.1373G>A	c.(1372-1374)AGA>AAA	p.R458K	ENTPD7_uc009xwl.2_Missense_Mutation_p.R460K	NM_020354	NP_065087	Q9NQZ7	ENTP7_HUMAN	ectonucleoside triphosphate diphosphohydrolase	458	Vesicular (Potential).					cytoplasmic vesicle membrane|integral to membrane	hydrolase activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;4.72e-10)|all cancers(201;3.75e-08)		CTAACTCAGAGATTCAAGAAT	0.443		NaN											0	0	0	0.00361	0	86	168									
DCLRE1A	9937	broad.mit.edu	37	10	115609492	115609492	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr10:115609492G>A	uc001law.2	-	2	2290	c.1372C>T	c.(1372-1374)CTT>TTT	p.L458F		NM_014881	NP_055696	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	458	Nuclear focus formation.				cell division|mitosis	nucleus	hydrolase activity			skin(2)	2				Epithelial(162;0.0157)|all cancers(201;0.0171)		ACTAACGGAAGAGAAACTTGA	0.343		NaN						Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	0.007413	0	19	38									
DCLRE1A	9937	broad.mit.edu	37	10	115610376	115610376	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr10:115610376G>C	uc001law.2	-	2	1406	c.488C>G	c.(487-489)TCA>TGA	p.S163*		NM_014881	NP_055696	Q6PJP8	DCR1A_HUMAN	DNA cross-link repair 1A	163	Nuclear localization region.				cell division|mitosis	nucleus	hydrolase activity			skin(2)	2				Epithelial(162;0.0157)|all cancers(201;0.0171)		AGGAATGGTTGAGGTACACAG	0.408		NaN						Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	0.008291	0	9	20									
STK32C	282974	broad.mit.edu	37	10	134059433	134059433	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr10:134059433G>A	uc001lle.1	-	2	429	c.289C>T	c.(289-291)CGG>TGG	p.R97W	STK32C_uc001lld.1_5'UTR|STK32C_uc010quu.1_Missense_Mutation_p.R110W|STK32C_uc009ybc.1_5'UTR|STK32C_uc009ybd.1_5'UTR|STK32C_uc001llc.1_RNA	NM_173575	NP_775846	Q86UX6	ST32C_HUMAN	serine/threonine kinase 32C	97	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|breast(1)	5		all_cancers(35;2.72e-11)|all_epithelial(44;2.33e-08)|Lung NSC(174;0.000855)|all_lung(145;0.00146)|all_neural(114;0.0299)|Breast(234;0.106)|Colorectal(31;0.112)|Melanoma(40;0.124)|Glioma(114;0.203)		Epithelial(32;3.99e-05)|all cancers(32;5.58e-05)|OV - Ovarian serous cystadenocarcinoma(35;9.96e-05)|BRCA - Breast invasive adenocarcinoma(275;0.222)		CCAATGGCCCGAAGGATCTGG	0.627		NaN											0	0	0	0.00333	0	22	58									
B4GALNT4	338707	broad.mit.edu	37	11	376347	376347	+	Silent	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:376347G>A	uc001lpb.2	+	13	1302	c.1293G>A	c.(1291-1293)CCG>CCA	p.P431P		NM_178537	NP_848632	Q76KP1	B4GN4_HUMAN	beta	431	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase activity			pancreas(1)	1		all_cancers(49;1.59e-06)|all_epithelial(84;0.000256)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;1.56e-27)|Epithelial(43;9.31e-27)|OV - Ovarian serous cystadenocarcinoma(40;1.11e-20)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0182)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TCCTCAACCCGGACGGTGAGT	0.617		NaN											0	0	0	0.001368	0	12	46									
OR52A4	390053	broad.mit.edu	37	11	5142584	5142584	+	Silent	SNP	A	A	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:5142584A>T	uc001lzz.1	-	1	225	c.225T>A	c.(223-225)ATT>ATA	p.I75I	OR52A4_uc001maa.2_RNA	NM_001005222	NP_001005222			olfactory receptor, family 52, subfamily A,											ovary(2)	2		Medulloblastoma(188;0.0049)|all_neural(188;0.0442)|Breast(177;0.0675)		Epithelial(150;1.7e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)|LUSC - Lung squamous cell carcinoma(625;0.2)		TGCTAAGTGAAATGTCTGTGG	0.428		NaN											0	0	0	0.00499	0	18	53									
DNHD1	144132	broad.mit.edu	37	11	6592276	6592276	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:6592276G>A	uc001mdw.3	+	42	14098	c.13534G>A	c.(13534-13536)GGC>AGC	p.G4512S	DNHD1_uc001mea.3_Missense_Mutation_p.G781S|DNHD1_uc001meb.2_3'UTR|DNHD1_uc001mec.2_Missense_Mutation_p.G780S|DNHD1_uc010rao.1_Missense_Mutation_p.G770S|DNHD1_uc009yfg.2_Missense_Mutation_p.G137S	NM_144666	NP_653267	Q96M86	DNHD1_HUMAN	dynein heavy chain domain 1 isoform 1	4512					microtubule-based movement	dynein complex	microtubule motor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.171)		Epithelial(150;3.93e-08)|BRCA - Breast invasive adenocarcinoma(625;0.13)		GCAGCTGAAGGGCGCACCCCC	0.682		NaN											0	0	0	0.003163	0	14	33									
DGKZ	8525	broad.mit.edu	37	11	46398102	46398102	+	Silent	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:46398102C>T	uc001ncn.1	+	25	2879	c.2754C>T	c.(2752-2754)ATC>ATT	p.I918I	DGKZ_uc001nch.1_Silent_p.I746I|DGKZ_uc010rgq.1_Silent_p.I673I|DGKZ_uc001ncj.1_Silent_p.I696I|DGKZ_uc010rgr.1_Silent_p.I695I|DGKZ_uc001nck.1_Silent_p.I508I|DGKZ_uc001ncl.2_Silent_p.I730I|DGKZ_uc001ncm.2_Silent_p.I729I|DGKZ_uc009yky.1_Silent_p.I730I|DGKZ_uc010rgs.1_Silent_p.I707I	NM_001105540	NP_001099010	Q13574	DGKZ_HUMAN	diacylglycerol kinase zeta isoform 4	918					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding	p.I746I(1)		pancreas(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		TCTACAGGATCGACCGAGCCC	0.672		NaN											0	0	0	0.002852	0	42	89									
OR4P4	81300	broad.mit.edu	37	11	55406520	55406520	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:55406520G>C	uc010rij.1	+	1	687	c.687G>C	c.(685-687)GAG>GAC	p.E229D		NM_001004124	NP_001004124	Q8NGL7	OR4P4_HUMAN	olfactory receptor, family 4, subfamily P,	229	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						ACTCTGCAGAGAGACGCAGCA	0.383		NaN											0	0	0	0.004656	0	26	56									
OR5F1	338674	broad.mit.edu	37	11	55761768	55761768	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:55761768A>G	uc010riv.1	-	1	334	c.334T>C	c.(334-336)TGC>CGC	p.C112R		NM_003697	NP_003688	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F,	112	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					AAGAGGATGCATTCGGTTGTC	0.473		NaN											0	0	0	0.007835	0	42	103									
PLCB3	5331	broad.mit.edu	37	11	64032574	64032574	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:64032574C>T	uc001nzb.2	+	23	2804	c.2804C>T	c.(2803-2805)CCA>CTA	p.P935L	PLCB3_uc009ypg.1_Missense_Mutation_p.P935L|PLCB3_uc009yph.1_Missense_Mutation_p.P868L|PLCB3_uc009ypi.2_Missense_Mutation_p.P935L	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3	935					intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						CTCAGCAGCCCAGGTAAGGAG	0.721		NaN											0	0	0	0.009096	0	3	4									
PLCB3	5331	broad.mit.edu	37	11	64033997	64033997	+	Silent	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:64033997C>T	uc001nzb.2	+	29	3387	c.3387C>T	c.(3385-3387)ATC>ATT	p.I1129I	PLCB3_uc009ypg.1_Silent_p.I1129I|PLCB3_uc009yph.1_Silent_p.I1062I|PLCB3_uc009ypi.2_Silent_p.I1129I	NM_000932	NP_000923	Q01970	PLCB3_HUMAN	phospholipase C beta 3	1129					intracellular signal transduction|lipid catabolic process|synaptic transmission	cytosol	calcium ion binding|calmodulin binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|pancreas(1)	2						GTCGGCACATCACTGAGTCAG	0.632		NaN											0	0	0	0.002096	0	28	57									
SF3B2	10992	broad.mit.edu	37	11	65831159	65831159	+	Silent	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:65831159C>G	uc001ogy.1	+	19	2329	c.2289C>G	c.(2287-2289)CTC>CTG	p.L763L		NM_006842	NP_006833	Q13435	SF3B2_HUMAN	splicing factor 3B subunit 2	763					interspecies interaction between organisms	catalytic step 2 spliceosome|nucleoplasm|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(2)|breast(1)	3						CCCCTGAACTCATTGAGCTGA	0.537		NaN											0	0	0	0.003163	0	13	27									
GSTP1	2950	broad.mit.edu	37	11	67353985	67353985	+	Silent	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:67353985C>G	uc001omf.2	+	7	819	c.570C>G	c.(568-570)CTC>CTG	p.L190L	GSTP1_uc001omg.1_Silent_p.L171L	NM_000852	NP_000843	P09211	GSTP1_HUMAN	glutathione transferase	190	GST C-terminal.				anti-apoptosis|cellular response to lipopolysaccharide|central nervous system development|common myeloid progenitor cell proliferation|glutathione metabolic process|negative regulation of acute inflammatory response|negative regulation of ERK1 and ERK2 cascade|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 beta production|negative regulation of JUN kinase activity|negative regulation of leukocyte proliferation|negative regulation of monocyte chemotactic protein-1 production|negative regulation of necrotic cell death|negative regulation of nitric-oxide synthase 2 biosynthetic process|negative regulation of stress-activated MAPK cascade|negative regulation of tumor necrosis factor production|nitric oxide storage|positive regulation of superoxide anion generation|response to reactive oxygen species|xenobiotic metabolic process	cytosol|protein complex	dinitrosyl-iron complex binding|glutathione transferase activity|JUN kinase binding|kinase regulator activity|nitric oxide binding|S-nitrosoglutathione binding			ovary(1)	1					Ethacrynic acid(DB00903)|Glutathione(DB00143)	GGCCCAAGCTCAAGGCCTTCC	0.627		NaN											0	0	0	0.004007	0	17	28									
GSTP1	2950	broad.mit.edu	37	11	67353995	67353995	+	Silent	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:67353995C>T	uc001omf.2	+	7	829	c.580C>T	c.(580-582)CTG>TTG	p.L194L	GSTP1_uc001omg.1_Silent_p.L175L	NM_000852	NP_000843	P09211	GSTP1_HUMAN	glutathione transferase	194	GST C-terminal.				anti-apoptosis|cellular response to lipopolysaccharide|central nervous system development|common myeloid progenitor cell proliferation|glutathione metabolic process|negative regulation of acute inflammatory response|negative regulation of ERK1 and ERK2 cascade|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 beta production|negative regulation of JUN kinase activity|negative regulation of leukocyte proliferation|negative regulation of monocyte chemotactic protein-1 production|negative regulation of necrotic cell death|negative regulation of nitric-oxide synthase 2 biosynthetic process|negative regulation of stress-activated MAPK cascade|negative regulation of tumor necrosis factor production|nitric oxide storage|positive regulation of superoxide anion generation|response to reactive oxygen species|xenobiotic metabolic process	cytosol|protein complex	dinitrosyl-iron complex binding|glutathione transferase activity|JUN kinase binding|kinase regulator activity|nitric oxide binding|S-nitrosoglutathione binding			ovary(1)	1					Ethacrynic acid(DB00903)|Glutathione(DB00143)	CAAGGCCTTCCTGGCCTCCCC	0.622		NaN											0	0	0	0.004007	0	16	23									
PDE2A	5138	broad.mit.edu	37	11	72292403	72292403	+	Silent	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:72292403G>A	uc010rrc.1	-	23	2286	c.2043C>T	c.(2041-2043)CTC>CTT	p.L681L	PDE2A_uc001oso.2_Silent_p.L660L|PDE2A_uc010rra.1_Silent_p.L674L|PDE2A_uc001osn.2_Silent_p.L425L|PDE2A_uc010rrb.1_Silent_p.L672L|PDE2A_uc010rrd.1_Silent_p.L566L	NM_002599	NP_002590	O00408	PDE2A_HUMAN	phosphodiesterase 2A isoform 1	681	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|cGMP-stimulated cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(2)|breast(1)|skin(1)	4			BRCA - Breast invasive adenocarcinoma(5;3.55e-05)		Sildenafil(DB00203)|Sulindac(DB00605)	CCACTCACTCGAGGTAGTTGG	0.532		NaN											0	0	0	0.006122	0	16	30									
POLD3	10714	broad.mit.edu	37	11	74303737	74303737	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:74303737G>A	uc001ovf.1	+	1	109	c.34G>A	c.(34-36)GAG>AAG	p.E12K	POLD3_uc009yua.1_5'UTR	NM_006591	NP_006582	Q15054	DPOD3_HUMAN	DNA-directed DNA polymerase delta 3	12					base-excision repair|DNA strand elongation involved in DNA replication|DNA synthesis involved in DNA repair|mismatch repair|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	delta DNA polymerase complex|nucleoplasm	DNA-directed DNA polymerase activity|protein binding			kidney(2)|ovary(1)	3	Breast(11;3.21e-06)					AAATATAGACGAGTTCGTCAC	0.642		NaN											0	0	0	0.003163	0	15	18									
FAT3	120114	broad.mit.edu	37	11	92531056	92531056	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:92531056G>A	uc001pdj.3	+	9	4894	c.4877G>A	c.(4876-4878)TGC>TAC	p.C1626Y		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	1626	Cadherin 15.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ATCACCATTTGCAAAGAACCA	0.453		NaN								TCGA Ovarian(4;0.039)			0	0	0	0.00361	0	47	73									
SIK3	23387	broad.mit.edu	37	11	116741051	116741052	+	Nonsense_Mutation	DNP	GC	GC	AA			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:116741051_116741052GC>AA	uc001ppy.2	-	14	1665_1666	c.1629_1630GC>TT	c.(1627-1632)GTGCAG>GTTTAG	p.Q544*	SIK3_uc001ppz.2_Nonsense_Mutation_p.Q443*|SIK3_uc001pqa.2_Nonsense_Mutation_p.Q496*|SIK3_uc001ppx.2_5'Flank	NM_025164	NP_079440	Q9Y2K2	SIK3_HUMAN	serine/threonine-protein kinase QSK	544						cytoplasm	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			ovary(4)|breast(3)|stomach(2)|lung(1)|skin(1)|kidney(1)	12						CATTACCTCTGCACAGCTTCCT	0.594		NaN									OREG0003489	type=REGULATORY REGION|Gene=BC063887|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	0	0	0	0.004672	0	12	27									
OR10G4	390264	broad.mit.edu	37	11	123886665	123886665	+	Silent	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:123886665G>A	uc010sac.1	+	1	384	c.384G>A	c.(382-384)CCG>CCA	p.P128P		NM_001004462	NP_001004462	Q8NGN3	O10G4_HUMAN	olfactory receptor, family 10, subfamily G,	128	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|central_nervous_system(1)	4		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		TCAGTTACCCGCTCAGGTACA	0.557		NaN											0	0	0	0.00361	0	50	125									
GLB1L3	112937	broad.mit.edu	37	11	134181051	134181051	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:134181051C>G	uc009zdf.2	+	13	1634	c.1274C>G	c.(1273-1275)TCC>TGC	p.S425C	GLB1L3_uc010scu.1_3'UTR|GLB1L3_uc001qho.3_RNA	NM_001080407	NP_001073876	Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1 like 3	425					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			pancreas(1)	1	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		GACGCCCTATCCTACTTAAAT	0.582		NaN											0	0	0	0.00361	0	114	196									
C12orf53	196500	broad.mit.edu	37	12	6806635	6806635	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr12:6806635C>T	uc001qqf.1	-	3	417	c.341G>A	c.(340-342)CGA>CAA	p.R114Q	C12orf53_uc001qqg.1_Missense_Mutation_p.R114Q	NM_153685	NP_710152	Q8IYJ0	CL053_HUMAN	hypothetical protein LOC196500 precursor	114	Extracellular (Potential).					integral to membrane					0						TCCATCCTCTCGAGACACGGT	0.632		NaN											0	0	0	0.006122	0	16	24									
ERGIC2	51290	broad.mit.edu	37	12	29498396	29498396	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr12:29498396G>A	uc001riv.2	-	11	938	c.805C>T	c.(805-807)CAG>TAG	p.Q269*	ERGIC2_uc001riw.2_RNA	NM_016570	NP_057654	Q96RQ1	ERGI2_HUMAN	PTX1 protein	269	Lumenal (Potential).				vesicle-mediated transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi apparatus|integral to membrane|nucleus				ovary(1)	1	Lung NSC(12;2.02e-08)|Acute lymphoblastic leukemia(23;0.00885)|all_hematologic(23;0.0155)|Lung SC(9;0.184)				Arsenic trioxide(DB01169)	ACAGAAAACTGATGGGTGTCT	0.303		NaN											0	0	0	0.002852	0	42	91									
IPO8	10526	broad.mit.edu	37	12	30802107	30802107	+	Silent	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr12:30802107G>A	uc001rjd.2	-	20	2402	c.2232C>T	c.(2230-2232)GTC>GTT	p.V744V	IPO8_uc001rje.1_Silent_p.V233V|IPO8_uc010sjt.1_Silent_p.V539V	NM_006390	NP_006381	O15397	IPO8_HUMAN	importin 8	744					intracellular protein transport|signal transduction	cytoplasm|nucleus	protein transporter activity|Ran GTPase binding			skin(2)|central_nervous_system(1)	3	all_lung(12;6.66e-10)|Lung NSC(12;4.84e-08)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0355)|Lung SC(12;0.0905)|Esophageal squamous(101;0.233)					GAAGAATGATGACTTCCAGAA	0.428		NaN											0	0	0	0.00623	0	37	77									
DENND5B	160518	broad.mit.edu	37	12	31540716	31540716	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr12:31540716G>T	uc001rki.1	-	21	3832	c.3646C>A	c.(3646-3648)CGC>AGC	p.R1216S	DENND5B_uc001rkh.1_Missense_Mutation_p.R1251S|DENND5B_uc009zjq.1_Intron	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	1216	RUN 2.					integral to membrane				ovary(1)|central_nervous_system(1)	2						GGGAGCAGGCGATCCCTACAG	0.527		NaN											1	0	2.31682e-05	0.003163	2.34923e-05	15	31									
MLL2	8085	broad.mit.edu	37	12	49427126	49427126	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr12:49427126G>A	uc001rta.3	-	39	11362	c.11362C>T	c.(11362-11364)CAG>TAG	p.Q3788*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	3788	Gln-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GACAGCTGCTGGACCAGGAGG	0.667		NaN	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.000602	0	5	6									
FMNL3	91010	broad.mit.edu	37	12	50050233	50050233	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr12:50050233C>T	uc001ruv.1	-	9	1073	c.839G>A	c.(838-840)CGA>CAA	p.R280Q	FMNL3_uc001ruw.1_Missense_Mutation_p.R229Q|FMNL3_uc001ruu.1_Missense_Mutation_p.R130Q	NM_175736	NP_783863	Q8IVF7	FMNL3_HUMAN	formin-like 3 isoform 1	280	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			breast(2)|pancreas(2)	4						GTGACCTCCTCGCACCAAACA	0.512		NaN											0	0	0	0.008291	0	10	32									
MYF5	4617	broad.mit.edu	37	12	81111214	81111214	+	Silent	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr12:81111214C>G	uc001szg.2	+	1	507	c.372C>G	c.(370-372)CTC>CTG	p.L124L		NM_005593	NP_005584	P13349	MYF5_HUMAN	myogenic factor 5	124	Helix-loop-helix motif.				muscle cell fate commitment|positive regulation of muscle cell differentiation|skeletal muscle tissue development	nucleoplasm	DNA binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(1)	1						TGGAGATCCTCAGGAATGCCA	0.597		NaN											0	0	0	0.00361	0	52	81									
SLC17A8	246213	broad.mit.edu	37	12	100751235	100751235	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr12:100751235G>C	uc010svi.1	+	1	379	c.66G>C	c.(64-66)AAG>AAC	p.K22N	SLC17A8_uc009ztx.2_Missense_Mutation_p.K22N	NM_139319	NP_647480	Q8NDX2	VGLU3_HUMAN	solute carrier family 17 (sodium-dependent	22	Cytoplasmic (Potential).				neurotransmitter transport|sensory perception of sound|sodium ion transport	cell junction|integral to membrane|synaptic vesicle membrane|synaptosome	L-glutamate transmembrane transporter activity|symporter activity			ovary(3)	3						AAGGAGTGAAGAACGCCGTGG	0.413		NaN											0	0	0	0.003755	0	36	88									
C12orf48	55010	broad.mit.edu	37	12	102576369	102576369	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr12:102576369A>T	uc001tjf.2	+	9	1339	c.1227A>T	c.(1225-1227)GAA>GAT	p.E409D	C12orf48_uc001tjg.2_Missense_Mutation_p.E328D|C12orf48_uc010swa.1_Missense_Mutation_p.E486D|C12orf48_uc001tjh.2_Missense_Mutation_p.E328D|C12orf48_uc010swb.1_Intron|C12orf48_uc009zuc.2_Intron|C12orf48_uc001tjj.2_Missense_Mutation_p.E124D|C12orf48_uc001tjk.2_Missense_Mutation_p.E288D|C12orf48_uc009zud.2_Intron	NM_017915	NP_060385	Q9NWS1	PR1BP_HUMAN	hypothetical protein LOC55010	409					response to DNA damage stimulus	cytoplasm|nucleus	DNA binding				0						CCCTAAGAGAACGCATCTGTG	0.264		NaN											0	0	0	0.001368	0	12	16									
HMGB1	3146	broad.mit.edu	37	13	31037474	31037474	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr13:31037474C>G	uc001usw.2	-	3	350	c.166G>C	c.(166-168)GAG>CAG	p.E56Q	HMGB1_uc001usz.2_Missense_Mutation_p.E56Q|HMGB1_uc001usv.2_Missense_Mutation_p.E56Q|HMGB1_uc001usx.2_Missense_Mutation_p.E56Q|HMGB1_uc001usy.2_Intron|HMGB1_uc001uta.1_Missense_Mutation_p.E56Q	NM_002128	NP_002119	P09429	HMGB1_HUMAN	high-mobility group box 1	56	HMG box 1.				base-excision repair, DNA ligation|dendritic cell chemotaxis|DNA fragmentation involved in apoptotic nuclear change|DNA topological change|inflammatory response to antigenic stimulus|innate immune response|myeloid dendritic cell activation|negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|neuron projection development|positive regulation of apoptosis|positive regulation of caspase activity|positive regulation of DNA binding|positive regulation of transcription from RNA polymerase II promoter|V(D)J recombination	cell surface|condensed chromosome|extracellular space|nucleolus|nucleoplasm	chemoattractant activity|cytokine activity|damaged DNA binding|DNA bending activity|double-stranded DNA binding|RAGE receptor binding|repressing transcription factor binding|sequence-specific DNA binding transcription factor activity|single-stranded DNA binding			ovary(1)	1		Lung SC(185;0.0257)		all cancers(112;0.072)|OV - Ovarian serous cystadenocarcinoma(117;0.177)|Lung(94;0.216)|GBM - Glioblastoma multiforme(144;0.232)		TTTCCTTTCTCTTTAGCAGAC	0.333		NaN											0	0	0	0.008361	0	31	36									
IRS2	8660	broad.mit.edu	37	13	110435362	110435362	+	Silent	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr13:110435362C>T	uc001vqv.2	-	1	3553	c.3039G>A	c.(3037-3039)CCG>CCA	p.P1013P		NM_003749	NP_003740	Q9Y4H2	IRS2_HUMAN	insulin receptor substrate 2	1013					fibroblast growth factor receptor signaling pathway|glucose metabolic process|insulin receptor signaling pathway|lipid homeostasis|negative regulation of B cell apoptosis|negative regulation of kinase activity|negative regulation of plasma membrane long-chain fatty acid transport|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of B cell proliferation|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|response to glucose stimulus	cytosol|plasma membrane	insulin receptor binding|signal transducer activity			large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|skin(1)|ovary(1)|kidney(1)	8	all_cancers(4;7.57e-15)|all_epithelial(4;5.91e-09)|all_lung(23;7.64e-07)|Lung NSC(43;0.000183)|Colorectal(4;0.00159)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0155)	Breast(118;0.159)	all cancers(43;0.00815)|BRCA - Breast invasive adenocarcinoma(86;0.11)|Epithelial(84;0.127)|GBM - Glioblastoma multiforme(44;0.147)			acggcggATACGGGGAGGAGG	0.368		NaN											0	0	0	0.004672	0	3	2									
TMEM55B	90809	broad.mit.edu	37	14	20929450	20929450	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr14:20929450G>A	uc001vxl.2	-	1	188	c.35C>T	c.(34-36)TCT>TTT	p.S12F	TMEM55B_uc001vxk.2_Missense_Mutation_p.S12F	NM_144568	NP_653169	Q86T03	TM55B_HUMAN	transmembrane protein 55B isoform 2	12						integral to membrane|late endosome membrane|lysosomal membrane	hydrolase activity				0	all_cancers(95;0.00123)	all_lung(585;0.235)	Epithelial(56;1.09e-07)|all cancers(55;1.19e-06)	GBM - Glioblastoma multiforme(265;0.0224)|READ - Rectum adenocarcinoma(17;0.193)		GATGGGCTCAGACAGCAGCGG	0.672		NaN											0	0	0	0.009096	0	3	4									
PRMT5	10419	broad.mit.edu	37	14	23397792	23397792	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr14:23397792G>T	uc001whm.1	-	2	234	c.143C>A	c.(142-144)CCG>CAG	p.P48Q	PRMT5_uc001whl.1_Missense_Mutation_p.P31Q|PRMT5_uc010akd.1_RNA|PRMT5_uc010tnf.1_Intron|PRMT5_uc010tng.1_Missense_Mutation_p.P31Q|PRMT5_uc010tnh.1_Missense_Mutation_p.P48Q|PRMT5_uc001whn.1_Missense_Mutation_p.P31Q	NM_006109	NP_006100	O14744	ANM5_HUMAN	protein arginine methyltransferase 5 isoform a	48					cell proliferation|histone H4-R3 methylation|ncRNA metabolic process|regulation of mitosis|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	histone-arginine N-methyltransferase activity|protein binding|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding			ovary(1)	1	all_cancers(95;2.76e-05)			GBM - Glioblastoma multiforme(265;0.0126)		CTTGAAACGCGGATGGAAGAC	0.537		NaN											1	0	3.01185e-09	0.003954	3.10831e-09	25	78									
CPNE6	9362	broad.mit.edu	37	14	24543758	24543758	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr14:24543758G>C	uc001wll.2	+	6	616	c.517G>C	c.(517-519)GAC>CAC	p.D173H	CPNE6_uc010tnv.1_Missense_Mutation_p.D228H|CPNE6_uc001wlm.2_5'UTR|CPNE6_uc001wln.2_5'Flank	NM_006032	NP_006023	O95741	CPNE6_HUMAN	copine 6	173	C2 2.				lipid metabolic process|nervous system development|synaptic transmission|vesicle-mediated transport		calcium ion binding|transporter activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0184)		CAGCAAGTCTGACCCTTTCAT	0.547		NaN											0	0	0	0.003954	0	23	64									
RALGAPA1	253959	broad.mit.edu	37	14	36121033	36121033	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr14:36121033G>A	uc001wti.2	-	30	4527	c.4136C>T	c.(4135-4137)TCA>TTA	p.S1379L	RALGAPA1_uc010amp.2_RNA|RALGAPA1_uc001wtj.2_Missense_Mutation_p.S1379L|RALGAPA1_uc010tpv.1_Missense_Mutation_p.S1392L|RALGAPA1_uc010tpw.1_Missense_Mutation_p.S1426L	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	1379	Minimal domain that binds to TCF3/E12 (By similarity).				activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						TTCATAAGATGAAGCCTCTGT	0.274		NaN											0	0	0	0.004656	0	25	64									
FAM179B	23116	broad.mit.edu	37	14	45478126	45478126	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr14:45478126C>G	uc001wvv.2	+	6	3124	c.2915C>G	c.(2914-2916)TCT>TGT	p.S972C	FAM179B_uc001wvw.2_Missense_Mutation_p.S972C|FAM179B_uc010anc.2_Intron	NM_015091	NP_055906	Q9Y4F4	F179B_HUMAN	hypothetical protein LOC23116	972	Ser-rich.						binding			skin(2)|upper_aerodigestive_tract(1)	3						ATGCATAGCTCTCTTAGGTCC	0.338		NaN											0	0	0	0.008871	0	21	47									
SIPA1L1	26037	broad.mit.edu	37	14	72125097	72125097	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr14:72125097G>A	uc001xms.2	+	6	2389	c.2041G>A	c.(2041-2043)GAA>AAA	p.E681K	SIPA1L1_uc001xmt.2_Missense_Mutation_p.E681K|SIPA1L1_uc001xmu.2_Missense_Mutation_p.E681K|SIPA1L1_uc001xmv.2_Missense_Mutation_p.E681K|SIPA1L1_uc010ttm.1_Missense_Mutation_p.E156K	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	681	Rap-GAP.				actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		CAAAGATTATGAAATTATGTT	0.348		NaN											0	0	0	0.00333	0	20	35									
LTBP2	4053	broad.mit.edu	37	14	75017811	75017811	+	Nonsense_Mutation	SNP	G	G	A	rs137854855		TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr14:75017811G>A	uc001xqa.2	-	7	2029	c.1642C>T	c.(1642-1644)CGA>TGA	p.R548*		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	548					protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		AGCAGTCCTCGAGGCCTGGGT	0.652		NaN											0	0	0	0.003163	0	15	39									
TRIP11	9321	broad.mit.edu	37	14	92471361	92471361	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr14:92471361G>C	uc001xzy.2	-	11	3747	c.2959C>G	c.(2959-2961)CAA>GAA	p.Q987E	TRIP11_uc010auf.1_Missense_Mutation_p.Q723E	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	thyroid hormone receptor interactor 11	987	Potential.				transcription from RNA polymerase II promoter	cytoskeleton|Golgi apparatus|membrane|nucleus	protein binding|transcription coactivator activity			ovary(6)|skin(2)|kidney(2)|central_nervous_system(1)|lung(1)|breast(1)	13				COAD - Colon adenocarcinoma(157;0.223)		TTATCTGTTTGAATGTCCTGT	0.333		NaN	T	PDGFRB	AML								0	0	0	0.003163	0	15	36									
SERPINA12	145264	broad.mit.edu	37	14	94964104	94964104	+	Missense_Mutation	SNP	G	G	C	rs61757459	byFrequency	TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr14:94964104G>C	uc001ydj.2	-	3	1427	c.631C>G	c.(631-633)CGA>GGA	p.R211G		NM_173850	NP_776249	Q8IW75	SPA12_HUMAN	serine (or cysteine) proteinase inhibitor, clade	211					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			central_nervous_system(2)|ovary(1)|lung(1)	4				COAD - Colon adenocarcinoma(157;0.235)		GCCTTACCTCGAAAGAAAATA	0.219		NaN											0	0	0	0.001855	0	14	41									
RTL1	388015	broad.mit.edu	37	14	101349412	101349412	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr14:101349412C>G	uc010txj.1	-	1	1773	c.1714G>C	c.(1714-1716)GAT>CAT	p.D572H	uc001yig.3_RNA|MIR127_hsa-mir-127|MI0000472_RNA|MIR432_hsa-mir-432|MI0003133_5'Flank|uc010txk.1_5'Flank|MIR136_hsa-mir-136|MI0000475_5'Flank	NM_001134888	NP_001128360	A6NKG5	RTL1_HUMAN	retrotransposon-like 1	572										pancreas(1)	1						GTCTCATCATCTGCTTCCTTC	0.572		NaN											0	0	0	0.00308	0	7	13									
AHNAK2	113146	broad.mit.edu	37	14	105413526	105413526	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr14:105413526C>A	uc010axc.1	-	7	8382	c.8262G>T	c.(8260-8262)AAG>AAT	p.K2754N	AHNAK2_uc001ypx.2_Missense_Mutation_p.K2654N	NM_138420	NP_612429	Q8IVF2	AHNK2_HUMAN	AHNAK nucleoprotein 2	2754						nucleus				ovary(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000479)|OV - Ovarian serous cystadenocarcinoma(23;0.00659)|Epithelial(46;0.0151)|GBM - Glioblastoma multiforme(11;0.116)			CGTTGGGGCCCTTAACATCTA	0.612		NaN											1	0	4.31119e-35	0.00361	4.63053e-35	100	172									
ACTC1	70	broad.mit.edu	37	15	35083368	35083368	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr15:35083368C>G	uc001ziu.1	-	6	1180	c.937G>C	c.(937-939)GAT>CAT	p.D313H	uc001zit.1_Intron	NM_005159	NP_005150	P68032	ACTC_HUMAN	cardiac muscle alpha actin 1 proprotein	313					apoptosis|cardiac muscle tissue morphogenesis|cardiac myofibril assembly|muscle filament sliding|skeletal muscle thin filament assembly	actomyosin, actin part|cytosol|I band	ATP binding|ATPase activity|myosin binding			upper_aerodigestive_tract(1)|ovary(1)	2		all_lung(180;2.3e-08)		all cancers(64;5.83e-19)|GBM - Glioblastoma multiforme(113;1.98e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0244)		TGCATACGATCAGCAATACCA	0.443		NaN											0	0	0	0.00361	0	77	152									
RPUSD2	27079	broad.mit.edu	37	15	40864067	40864067	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr15:40864067G>A	uc001zmd.1	+	2	871	c.871G>A	c.(871-873)GAG>AAG	p.E291K		NM_152260	NP_689473	Q8IZ73	RUSD2_HUMAN	RNA pseudouridylate synthase domain containing	291					pseudouridine synthesis		protein binding|pseudouridine synthase activity|RNA binding			skin(1)	1		all_cancers(109;2.74e-14)|all_epithelial(112;1.64e-11)|Lung NSC(122;6.69e-09)|all_lung(180;1.22e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;3.1e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0786)		TGCAGTCTCTGAGAGAATTCA	0.552		NaN											0	0	0	0.003755	0	31	81									
CTDSPL2	51496	broad.mit.edu	37	15	44778881	44778881	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr15:44778881C>T	uc001ztr.2	+	4	874	c.458C>T	c.(457-459)TCA>TTA	p.S153L	CTDSPL2_uc001zts.2_Missense_Mutation_p.S153L|CTDSPL2_uc001ztt.2_Missense_Mutation_p.S153L|CTDSPL2_uc010bdv.2_Missense_Mutation_p.S153L	NM_016396	NP_057480	Q05D32	CTSL2_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	153							phosphoprotein phosphatase activity				0		all_cancers(109;4.36e-14)|all_epithelial(112;9.8e-12)|Lung NSC(122;1.66e-07)|all_lung(180;1.47e-06)|Melanoma(134;0.0122)		all cancers(107;1.02e-20)|GBM - Glioblastoma multiforme(94;1.49e-06)|COAD - Colon adenocarcinoma(120;0.0857)|Colorectal(105;0.0905)		AACTTTTTTTCACCAGCAAAT	0.289		NaN											0	0	0	0.00333	0	22	80									
BCL2L10	10017	broad.mit.edu	37	15	52402123	52402123	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr15:52402123C>A	uc002abq.2	-	2	586	c.537G>T	c.(535-537)TGG>TGT	p.W179C		NM_020396	NP_065129	Q9HD36	B2L10_HUMAN	BCL2-like 10 (apoptosis facilitator)	169					activation of caspase activity|anti-apoptosis|female gamete generation|spermatogenesis	cytosol|integral to membrane|membrane fraction|mitochondrion|nuclear membrane	protein binding				0				all cancers(107;0.0148)		GCTGTTTTCTCCAAAAAGCCA	0.438		NaN											1	0	1.63498e-16	0.00361	1.72416e-16	65	110									
TCF12	6938	broad.mit.edu	37	15	57545488	57545488	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr15:57545488G>C	uc002aec.2	+	15	1501	c.1217G>C	c.(1216-1218)AGA>ACA	p.R406T	TCF12_uc010ugm.1_Missense_Mutation_p.R458T|TCF12_uc010ugn.1_Missense_Mutation_p.R426T|TCF12_uc002aea.2_Missense_Mutation_p.R430T|TCF12_uc010bfs.2_Intron|TCF12_uc002aeb.2_Missense_Mutation_p.R430T|TCF12_uc002aed.2_Missense_Mutation_p.R406T|TCF12_uc002aee.2_Missense_Mutation_p.R236T|TCF12_uc010bft.2_Missense_Mutation_p.R260T|TCF12_uc010ugo.1_Missense_Mutation_p.R170T|TCF12_uc010ugp.1_Missense_Mutation_p.R64T|TCF12_uc010ugq.1_Missense_Mutation_p.R40T|TCF12_uc010ugr.1_Missense_Mutation_p.R19T	NM_207038	NP_996921	Q99081	HTF4_HUMAN	transcription factor 12 isoform b	406					immune response|muscle organ development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(5)|ovary(2)|lung(1)	8		Colorectal(260;0.0907)		all cancers(107;0.000313)|GBM - Glioblastoma multiforme(80;0.00878)|STAD - Stomach adenocarcinoma(283;0.239)		CGTTTAGACAGACTGGATGAT	0.443		NaN	T	TEC	extraskeletal myxoid chondrosarcoma								0	0	0	0.005443	0	23	66									
CRAMP1L	57585	broad.mit.edu	37	16	1712505	1712505	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr16:1712505C>G	uc010uvh.1	+	11	2428	c.2428C>G	c.(2428-2430)CCA>GCA	p.P810A	CRAMP1L_uc002cmf.2_RNA	NM_020825	NP_065876	Q96RY5	CRML_HUMAN	Crm, cramped-like	810						nucleus	DNA binding				0						GAGAAACCCTCCAAGACCCCT	0.547		NaN											0	0	0	0.00361	0	52	98									
CREBBP	1387	broad.mit.edu	37	16	3819201	3819201	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr16:3819201C>T	uc002cvv.2	-	15	3238	c.3034G>A	c.(3034-3036)GAA>AAA	p.E1012K	CREBBP_uc002cvw.2_Missense_Mutation_p.E974K	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1012					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		CCTTTGGATTCACCAGGATCG	0.592		NaN	T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				0	0	0	0.005524	0	36	57									
SEC14L5	9717	broad.mit.edu	37	16	5040888	5040888	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr16:5040888G>A	uc002cye.2	+	5	646	c.466G>A	c.(466-468)GTC>ATC	p.V156I		NM_014692	NP_055507	O43304	S14L5_HUMAN	SEC14-like 5	156	PRELI/MSF1.					integral to membrane|intracellular	transporter activity				0						CACCGCCAACGTCAAGAGGGT	0.403		NaN											0	0	0	0.009096	0	4	7									
PLK1	5347	broad.mit.edu	37	16	23690256	23690256	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr16:23690256G>A	uc002dlz.1	+	1	56	c.3G>A	c.(1-3)ATG>ATA	p.M1I		NM_005030	NP_005021	P53350	PLK1_HUMAN	polo-like kinase 1	1					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|G2/M transition DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitotic metaphase/anaphase transition|mitotic prometaphase|mitotic prophase|negative regulation of cyclin-dependent protein kinase activity|peptidyl-serine phosphorylation|positive regulation of peptidyl-threonine phosphorylation|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein destabilization|protein localization to chromatin|protein ubiquitination|regulation of mitotic anaphase|regulation of protein binding	centrosome|condensed nuclear chromosome outer kinetochore|cytosol|nucleoplasm|spindle microtubule|spindle midzone|spindle pole	anaphase-promoting complex binding|ATP binding|polo kinase kinase activity|protein kinase binding			lung(1)|skin(1)	2				GBM - Glioblastoma multiforme(48;0.0156)		TCGGGAGCATGAGTGCTGCAG	0.682		NaN											0	0	0	0.004672	0	3	3									
TNRC6A	27327	broad.mit.edu	37	16	24800967	24800967	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr16:24800967C>T	uc002dmm.2	+	6	1118	c.1004C>T	c.(1003-1005)TCT>TTT	p.S335F	TNRC6A_uc010bxs.2_Missense_Mutation_p.S82F|TNRC6A_uc010vcc.1_Missense_Mutation_p.S82F|TNRC6A_uc002dmn.2_Missense_Mutation_p.S82F|TNRC6A_uc002dmo.2_Missense_Mutation_p.S82F	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	335	Sufficient for interaction with EIF2C2.|Sufficient for interaction with EIF2C1, EIF2C3 and EIF2C4.|Ser-rich.|Sufficient for interaction with EIF2C2.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		GAAAGCAAATCTGAAAGTAGC	0.438		NaN											0	0	0	0.004878	0	39	49									
CCDC101	112869	broad.mit.edu	37	16	28601977	28601977	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr16:28601977G>C	uc002dqf.2	+	8	777	c.592G>C	c.(592-594)GAA>CAA	p.E198Q	uc010vct.1_Intron	NM_138414	NP_612423	Q96ES7	SGF29_HUMAN	coiled-coil domain containing 101	198	SGF29 C-terminal.				establishment of protein localization to chromatin|histone H3 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Ada2/Gcn5/Ada3 transcription activator complex|SAGA-type complex	methylated histone residue binding			central_nervous_system(1)	1						CATCGATGAAGAAGGCAAAGA	0.577		NaN											0	0	0	0.00361	0	77	138									
CDH11	1009	broad.mit.edu	37	16	65032529	65032529	+	Silent	SNP	A	A	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr16:65032529A>G	uc002eoi.2	-	4	893	c.459T>C	c.(457-459)AAT>AAC	p.N153N	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_Silent_p.N153N|CDH11_uc010vin.1_Silent_p.N27N|CDH11_uc010vio.1_Silent_p.N153N	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	153	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		GAGGGTTGTCATTAATGTCCT	0.582		NaN	T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			0	0	0	0.008361	0	29	55									
CDH5	1003	broad.mit.edu	37	16	66432402	66432402	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr16:66432402G>A	uc002eom.3	+	10	1685	c.1529G>A	c.(1528-1530)CGA>CAA	p.R510Q		NM_001795	NP_001786	P33151	CADH5_HUMAN	cadherin 5, type 2 preproprotein	510	Cadherin 5.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		ATAACACCACGAAACGTGAAG	0.443		NaN											0	0	0	0.004007	0	16	35									
PARD6A	50855	broad.mit.edu	37	16	67696116	67696116	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr16:67696116G>A	uc002ett.2	+	3	698	c.607G>A	c.(607-609)GCT>ACT	p.A203T	ACD_uc002etp.3_5'Flank|ACD_uc002etq.3_5'Flank|ACD_uc002etr.3_5'Flank|ACD_uc010vjt.1_5'Flank|PARD6A_uc002ets.2_Missense_Mutation_p.A202T|PARD6A_uc002etu.2_Missense_Mutation_p.A27T	NM_016948	NP_058644	Q9NPB6	PAR6A_HUMAN	par-6 partitioning defective 6 homolog alpha	203	PDZ.|Interaction with PARD3 and CDC42 (By similarity).				cell cycle|cell division|cell-cell junction maintenance|tight junction assembly|viral reproduction	cytosol|nucleus|ruffle|tight junction	GTP-dependent protein binding|Rho GTPase binding|transcription factor binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		TGGGGGTCTGGCTGAGAGTAC	0.597		NaN											0	0	0	0.005524	0	39	67									
NFAT5	10725	broad.mit.edu	37	16	69693744	69693744	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr16:69693744C>G	uc002exm.1	+	6	2465	c.1257C>G	c.(1255-1257)ATC>ATG	p.I419M	NFAT5_uc002exh.1_Missense_Mutation_p.I213M|NFAT5_uc002exi.2_Missense_Mutation_p.I343M|NFAT5_uc002exj.1_Missense_Mutation_p.I343M|NFAT5_uc002exk.1_Missense_Mutation_p.I343M|NFAT5_uc002exl.1_Missense_Mutation_p.I437M|NFAT5_uc002exn.1_Missense_Mutation_p.I437M	NM_006599	NP_006590	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5 isoform c	419	RHD.				excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						GAGTTAATATCATGAGGAAAG	0.398		NaN											0	0	0	0.003214	0	46	61									
HYDIN	54768	broad.mit.edu	37	16	70934909	70934909	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr16:70934909C>A	uc002ezr.2	-	53	9171	c.9043G>T	c.(9043-9045)GAG>TAG	p.E3015*		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	3016										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				AGCCTCACCTCCAACCGAATA	0.418		NaN											1	0	1.414e-09	0.003755	1.4645e-09	24	181									
C16orf7	9605	broad.mit.edu	37	16	89779125	89779125	+	Splice_Site	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr16:89779125C>T	uc002fom.1	-	5	557	c.432_splice	c.e5-1	p.K144_splice	C16orf7_uc002fol.1_Splice_Site_p.K74_splice|uc002fon.1_RNA	NM_004913	NP_004904	Q9Y2B5	CP007_HUMAN	chromosome 16 open reading frame 7						ATP synthesis coupled proton transport		GTPase activator activity|transporter activity				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		CGTCAGCTCTCTGGAAATGTG	0.607		NaN											0	0	0	0.004482	0	9	26									
FANCA	2175	broad.mit.edu	37	16	89845229	89845229	+	Silent	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr16:89845229C>T	uc002fou.1	-	20	1848	c.1806G>A	c.(1804-1806)GCG>GCA	p.A602A	FANCA_uc010vpn.1_Silent_p.A602A	NM_000135	NP_000126	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A isoform	602					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		ACTCTATAAACGCCACACGGG	0.478		NaN	D|Mis|N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.00361	0	44	84									
FANCA	2175	broad.mit.edu	37	16	89858462	89858462	+	Silent	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr16:89858462C>T	uc002fou.1	-	13	1140	c.1098G>A	c.(1096-1098)CTG>CTA	p.L366L	FANCA_uc010vpn.1_Silent_p.L366L	NM_000135	NP_000126	O15360	FANCA_HUMAN	Fanconi anemia, complementation group A isoform	366					DNA repair|protein complex assembly	cytoplasm|nucleoplasm	protein binding			ovary(2)|breast(2)|central_nervous_system(1)|skin(1)	6		Lung NSC(15;8.48e-06)|all_lung(18;1.31e-05)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.028)		CCTCTGCACTCAGCATCACAA	0.527		NaN	D|Mis|N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.002299	0	21	73									
VPS53	55275	broad.mit.edu	37	17	617947	617947	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr17:617947C>G	uc002frn.2	-	1	150	c.3G>C	c.(1-3)ATG>ATC	p.M1I	VPS53_uc010cjo.1_Missense_Mutation_p.M1I|VPS53_uc002frl.2_RNA|VPS53_uc002frm.2_Missense_Mutation_p.M1I|VPS53_uc002fro.2_5'UTR|VPS53_uc010cjp.1_Missense_Mutation_p.M1I	NM_018289	NP_060759	Q5VIR6	VPS53_HUMAN	vacuolar protein sorting 53 isoform 2	1					protein transport	endosome membrane|Golgi apparatus					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0265)		CCTCCTCCATCATTCCGCCAC	0.706		NaN											0	0	0	0.004289	0	35	79									
CLEC10A	10462	broad.mit.edu	37	17	6979314	6979314	+	Silent	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr17:6979314G>A	uc002gek.2	-	6	813	c.510C>T	c.(508-510)CTC>CTT	p.L170L	CLEC10A_uc002gej.2_Silent_p.L143L|CLEC10A_uc002gel.2_Silent_p.L143L|CLEC10A_uc010clv.1_Silent_p.L143L	NM_182906	NP_878910	Q8IUN9	CLC10_HUMAN	C-type lectin, superfamily member 14 isoform 1	170	Extracellular (Potential).|Potential.				endocytosis|innate immune response	integral to membrane|plasma membrane	sugar binding				0						CATTGTTGTTGAGAGTAGCCA	0.547		NaN											0	0	0	0.00632	0	27	51									
CLEC10A	10462	broad.mit.edu	37	17	6980295	6980295	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr17:6980295G>A	uc002gek.2	-	4	499	c.196C>T	c.(196-198)CAG>TAG	p.Q66*	CLEC10A_uc002gej.2_Nonsense_Mutation_p.Q66*|CLEC10A_uc002gel.2_Nonsense_Mutation_p.Q66*|CLEC10A_uc010clv.1_Nonsense_Mutation_p.Q66*	NM_182906	NP_878910	Q8IUN9	CLC10_HUMAN	C-type lectin, superfamily member 14 isoform 1	66	Extracellular (Potential).				endocytosis|innate immune response	integral to membrane|plasma membrane	sugar binding				0						AGGTCCCTCTGAAATTTGGAA	0.393		NaN											0	0	0	0.002096	0	32	47									
ALOX12B	242	broad.mit.edu	37	17	7984221	7984221	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr17:7984221G>A	uc002gjy.1	-	4	769	c.508C>T	c.(508-510)CGC>TGC	p.R170C	uc010cnq.1_RNA	NM_001139	NP_001130	O75342	LX12B_HUMAN	arachidonate 12-lipoxygenase, 12R type	170	Lipoxygenase.				epidermis development|leukotriene biosynthetic process		arachidonate 12-lipoxygenase activity|iron ion binding|lipoxygenase activity				0						TTGGGGTTGCGATGCCTCCGC	0.652		NaN								Multiple Myeloma(8;0.094)			0	0	0	0.00361	0	59	95									
DNAH9	1770	broad.mit.edu	37	17	11607583	11607583	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr17:11607583G>C	uc002gne.2	+	25	5283	c.5215G>C	c.(5215-5217)GAG>CAG	p.E1739Q	DNAH9_uc010coo.2_Missense_Mutation_p.E1033Q	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	1739	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		TGCCAGGCTGGAGGAAGGCTA	0.512		NaN											0	0	0	0.006999	0	39	86									
SMCR8	140775	broad.mit.edu	37	17	18221435	18221435	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr17:18221435C>A	uc002gsy.3	+	1	2842	c.2332C>A	c.(2332-2334)CAG>AAG	p.Q778K		NM_144775	NP_658988	Q8TEV9	SMCR8_HUMAN	Smith-Magenis syndrome chromosome region,	778										central_nervous_system(1)	1						TATGGATTTTCAGAAGTGGAA	0.522		NaN											1	0	1.38658e-30	0.00361	1.48379e-30	47	92									
PSMD11	5717	broad.mit.edu	37	17	30807212	30807212	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr17:30807212C>T	uc010cta.1	+	12	1163	c.1123C>T	c.(1123-1125)CAT>TAT	p.H375Y	PSMD11_uc002hhm.2_Missense_Mutation_p.H375Y	NM_002815	NP_002806	O00231	PSD11_HUMAN	proteasome 26S non-ATPase subunit 11	375	PCI.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	protein binding			ovary(1)	1		Breast(31;0.159)|Ovarian(249;0.182)	BRCA - Breast invasive adenocarcinoma(9;0.109)			CAAGAAATTTCATGGTAAGTA	0.408		NaN											0	0	0	0.00361	0	46	81									
GAS2L2	246176	broad.mit.edu	37	17	34079687	34079687	+	Silent	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr17:34079687C>T	uc002hjv.1	-	1	211	c.183G>A	c.(181-183)ACG>ACA	p.T61T		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	61	CH.				cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GCACCAGGCCCGTTTCCAGCA	0.627		NaN											0	0	0	0.00333	0	25	51									
ACACA	31	broad.mit.edu	37	17	35614640	35614640	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr17:35614640C>T	uc002hnm.2	-	14	1891	c.1700G>A	c.(1699-1701)AGA>AAA	p.R567K	ACACA_uc002hnk.2_Missense_Mutation_p.R489K|ACACA_uc002hnl.2_Missense_Mutation_p.R509K|ACACA_uc002hnn.2_Missense_Mutation_p.R567K|ACACA_uc002hno.2_Missense_Mutation_p.R604K|ACACA_uc010cuz.2_Missense_Mutation_p.R567K	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	567	Biotin carboxylation.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TGCCTCTTCTCTGTTTTCTCC	0.378		NaN											0	0	0	0.007413	0	17	44									
HELZ	9931	broad.mit.edu	37	17	65104787	65104787	+	Silent	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr17:65104787G>A	uc010wqk.1	-	30	4735	c.4548C>T	c.(4546-4548)TTC>TTT	p.F1516F	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Silent_p.F1515F|HELZ_uc010der.2_Silent_p.F59F	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					TCCACTGCTGGAACCGTGCCT	0.502		NaN											0	0	0	0.004878	0	37	61									
KIAA0195	9772	broad.mit.edu	37	17	73491426	73491426	+	Silent	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr17:73491426C>T	uc002jnz.3	+	21	3065	c.2790C>T	c.(2788-2790)ATC>ATT	p.I930I	KIAA0195_uc010wsa.1_Silent_p.I940I|KIAA0195_uc010wsb.1_Silent_p.I570I|KIAA0195_uc002job.3_5'Flank	NM_014738	NP_055553	Q12767	K0195_HUMAN	hypothetical protein LOC9772	930					ATP biosynthetic process|cation transport	integral to membrane	ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism			ovary(1)	1	all_cancers(13;3.15e-09)|all_epithelial(9;5.94e-10)|Breast(9;1.85e-09)|all_lung(278;0.246)		all cancers(21;5.01e-07)|Epithelial(20;5e-06)|Lung(188;0.0809)|LUSC - Lung squamous cell carcinoma(166;0.154)			CGGACCTCATCAGCTTCCAGC	0.597		NaN											0	0	0	0.007413	0	16	53									
EVPL	2125	broad.mit.edu	37	17	74005847	74005847	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr17:74005847C>T	uc002jqi.2	-	22	3667	c.3439G>A	c.(3439-3441)GGG>AGG	p.G1147R	EVPL_uc010wss.1_Missense_Mutation_p.G1169R|EVPL_uc010wst.1_Missense_Mutation_p.G617R	NM_001988	NP_001979	Q92817	EVPL_HUMAN	envoplakin	1147	Central fibrous rod domain.				keratinization|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural molecule activity			pancreas(2)|central_nervous_system(1)|skin(1)	4						TGGAGGAGCCCTGGGTCCTGC	0.632		NaN											0	0	0	0.004878	0	30	55									
NDC80	10403	broad.mit.edu	37	18	2608705	2608705	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr18:2608705G>C	uc002kli.2	+	15	1746	c.1564G>C	c.(1564-1566)GAG>CAG	p.E522Q		NM_006101	NP_006092	O14777	NDC80_HUMAN	kinetochore associated 2	522	Potential.|Interaction with the C-terminus of CDCA1 and the SPBC24-SPBC25 subcomplex.|Interaction with NEK2 and ZWINT.|Interaction with PSMC2 and SMC1A.				attachment of spindle microtubules to kinetochore|cell division|establishment of mitotic spindle orientation|mitotic prometaphase|mitotic sister chromatid segregation|mitotic spindle organization|phosphatidylinositol-mediated signaling	condensed nuclear chromosome outer kinetochore|cytosol|Ndc80 complex	protein binding			ovary(1)	1						ATAGGAAGCAGAGGAAGAGGA	0.388		NaN											0	0	0	0.005443	0	24	40									
CEP192	55125	broad.mit.edu	37	18	13068356	13068356	+	Splice_Site	SNP	A	A	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr18:13068356A>G	uc010xac.1	+	24	4839	c.4759_splice	c.e24-2	p.D1587_splice	CEP192_uc010dlf.1_Splice_Site|CEP192_uc010xad.1_Splice_Site_p.D1112_splice|CEP192_uc002kru.2_Splice_Site|CEP192_uc002krv.2_Splice_Site_p.D9_splice|CEP192_uc002krw.2_5'Flank	NM_032142	NP_115518	E9PF99	E9PF99_HUMAN	centrosomal protein 192kDa											ovary(4)|pancreas(1)	5						TTAATTTTATAGGATCCAGAA	0.294		NaN											0	0	0	0.006122	0	18	27									
KIAA1012	22878	broad.mit.edu	37	18	29437531	29437531	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr18:29437531C>T	uc002kxc.3	-	20	3524	c.3160G>A	c.(3160-3162)GAA>AAA	p.E1054K	KIAA1012_uc002kxb.3_Missense_Mutation_p.E1000K|KIAA1012_uc002kxd.3_RNA	NM_014939	NP_055754	Q9Y2L5	TPPC8_HUMAN	hypothetical protein LOC22878	1054					ER to Golgi vesicle-mediated transport	cis-Golgi network					0						TTGACACTTTCATAGTAAAAC	0.348		NaN											0	0	0	0.007413	0	18	37									
SMAD2	4087	broad.mit.edu	37	18	45372078	45372078	+	Missense_Mutation	SNP	T	T	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr18:45372078T>G	uc002lcy.2	-	9	1339	c.1091A>C	c.(1090-1092)CAG>CCG	p.Q364P	SMAD2_uc002lcz.2_Missense_Mutation_p.Q364P|SMAD2_uc010xdc.1_Missense_Mutation_p.Q334P|SMAD2_uc010xdd.1_Missense_Mutation_p.Q334P	NM_005901	NP_005892	Q15796	SMAD2_HUMAN	Sma- and Mad-related protein 2 isoform 1	364	MH2.				anterior/posterior pattern formation|cell fate commitment|common-partner SMAD protein phosphorylation|intracellular signal transduction|mesoderm formation|negative regulation of transcription, DNA-dependent|palate development|paraxial mesoderm morphogenesis|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription from RNA polymerase II promoter|primary miRNA processing|regulation of binding|regulation of transforming growth factor beta receptor signaling pathway|response to cholesterol|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway|zygotic specification of dorsal/ventral axis	activin responsive factor complex|cytosol	activating transcription factor binding|co-SMAD binding|double-stranded DNA binding|I-SMAD binding|R-SMAD binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity|type I transforming growth factor beta receptor binding|ubiquitin protein ligase binding			large_intestine(3)|lung(1)|central_nervous_system(1)	5						GCCATATCTCTGATTACAATT	0.418		NaN											0	0	0	0.007835	0	42	52									
MYO5B	4645	broad.mit.edu	37	18	47379927	47379927	+	Silent	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr18:47379927C>T	uc002leb.2	-	31	4401	c.4113G>A	c.(4111-4113)GAG>GAA	p.E1371E	MYO5B_uc002lea.2_Silent_p.E486E	NM_001080467	NP_001073936	Q9ULV0	MYO5B_HUMAN	myosin VB	1371	Potential.				protein transport	myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			ovary(2)|skin(2)|central_nervous_system(1)	5				READ - Rectum adenocarcinoma(32;0.103)		GTTTGTCCATCTCCTCCTTCA	0.617		NaN											0	0	0	0.002299	0	21	51									
PIGN	23556	broad.mit.edu	37	18	59824982	59824982	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr18:59824982G>T	uc002lii.3	-	5	729	c.281C>A	c.(280-282)TCT>TAT	p.S94Y	PIGN_uc002lij.3_Missense_Mutation_p.S94Y	NM_176787	NP_789744	O95427	PIGN_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	94	Lumenal (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	phosphotransferase activity, for other substituted phosphate groups			breast(2)|upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	5		Colorectal(73;0.187)				ACCTGGCCGAGATTCTGTTGG	0.378		NaN											1	0	0.000602214	0.000602	0.000606396	5	20									
SERPINB4	6318	broad.mit.edu	37	18	61328322	61328322	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr18:61328322T>A	uc002ljg.2	-	1	155	c.129A>T	c.(127-129)TTA>TTT	p.L43F	SERPINB3_uc002lji.2_Missense_Mutation_p.L43F|SERPINB3_uc010dqa.2_Missense_Mutation_p.L43F|SERPINB3_uc010dqb.2_Missense_Mutation_p.L43F|SERPINB3_uc010dqc.2_Missense_Mutation_p.L43F			P48594	SPB4_HUMAN	SubName: Full=Squamous cell carcinoma antigen 2;	43					immune response|regulation of proteolysis	cytoplasm|extracellular region	protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|lung(1)	3						CTTTGGCTCCTAAGAGGACCA	0.438		NaN											0	0	0	0.00361	0	40	100									
ZNF236	7776	broad.mit.edu	37	18	74616410	74616411	+	Missense_Mutation	DNP	AG	AG	GA			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr18:74616410_74616411AG>GA	uc002lmi.2	+	12	2161_2162	c.1963_1964AG>GA	c.(1963-1965)AGA>GAA	p.R655E	ZNF236_uc002lmj.2_RNA	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	655					cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		TGAAGCAGATAGACCATACAAG	0.347		NaN											0	0	0	0.004672	0	18	23									
PTPRS	5802	broad.mit.edu	37	19	5222225	5222225	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:5222225G>A	uc002mbv.2	-	19	3344	c.3110C>T	c.(3109-3111)CCC>CTC	p.P1037L	PTPRS_uc002mbu.1_Missense_Mutation_p.P606L|PTPRS_uc010xin.1_Missense_Mutation_p.P606L|PTPRS_uc002mbw.2_Missense_Mutation_p.P1015L|PTPRS_uc002mbx.2_Missense_Mutation_p.P610L|PTPRS_uc002mby.2_Missense_Mutation_p.P606L	NM_002850	NP_002841	Q13332	PTPRS_HUMAN	protein tyrosine phosphatase, receptor type,	1037	Extracellular (Potential).|Fibronectin type-III 8.				cell adhesion	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			large_intestine(2)|ovary(1)|central_nervous_system(1)	4				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0321)|Lung(535;0.182)		GAAGTTCTTGGGCGAGACTGC	0.607		NaN											0	0	0	0.004672	0	3	39									
AP1M2	10053	broad.mit.edu	37	19	10689595	10689595	+	Silent	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:10689595G>C	uc002mpc.2	-	8	945	c.861C>G	c.(859-861)TCC>TCG	p.S287S	AP1M2_uc002mpd.2_Silent_p.S289S	NM_005498	NP_005489	Q9Y6Q5	AP1M2_HUMAN	adaptor-related protein complex 1, mu 2 subunit	287	MHD.				cellular membrane organization|post-Golgi vesicle-mediated transport|protein targeting|regulation of defense response to virus by virus|vesicle targeting|viral reproduction	clathrin adaptor complex|clathrin coated vesicle membrane|cytosol|Golgi membrane|lysosomal membrane	protein binding			ovary(2)	2			Epithelial(33;1.58e-05)|all cancers(31;6.36e-05)			CGCGGCTGTGGGAGAACTTCT	0.418		NaN											0	0	0	0.004672	0	3	18									
SMARCA4	6597	broad.mit.edu	37	19	11168977	11168977	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:11168977C>T	uc002mqf.3	+	31	4755	c.4471C>T	c.(4471-4473)CGA>TGA	p.R1491*	SMARCA4_uc010dxp.2_Nonsense_Mutation_p.R1491*|SMARCA4_uc010dxo.2_Nonsense_Mutation_p.R1523*|SMARCA4_uc010dxq.2_Nonsense_Mutation_p.R1458*|SMARCA4_uc010dxr.2_Nonsense_Mutation_p.R1457*|SMARCA4_uc002mqj.3_Nonsense_Mutation_p.R1461*|SMARCA4_uc010dxs.2_Nonsense_Mutation_p.R1460*|SMARCA4_uc002mqh.3_Nonsense_Mutation_p.R581*	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	1491	Bromo.				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity			lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				GCTGCCCTCGCGAAAGGAGCT	0.637		NaN	F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				0	0	0	0.001368	0	13	28									
FKBP8	23770	broad.mit.edu	37	19	18650429	18650429	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:18650429C>G	uc002njk.1	-	3	507	c.394G>C	c.(394-396)GAG>CAG	p.E132Q	FKBP8_uc002nji.1_5'UTR|FKBP8_uc010xqi.1_Missense_Mutation_p.E161Q|FKBP8_uc002njj.1_Missense_Mutation_p.E132Q|FKBP8_uc002njl.1_Missense_Mutation_p.E132Q|FKBP8_uc002njm.1_Missense_Mutation_p.E132Q|FKBP8_uc010ebr.1_Intron|FKBP8_uc002njn.2_RNA	NM_012181	NP_036313	Q14318	FKBP8_HUMAN	FK506-binding protein 8	132	PPIase FKBP-type.				apoptosis|interspecies interaction between organisms|intracellular signal transduction|protein folding	integral to endoplasmic reticulum membrane|mitochondrial membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|protein binding			ovary(1)	1						GTGCCATTCTCCAGCGACGTC	0.667		NaN											0	0	0	0.00361	0	71	83									
FKBP8	23770	broad.mit.edu	37	19	18650529	18650529	+	Silent	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:18650529C>T	uc002njk.1	-	3	407	c.294G>A	c.(292-294)GGG>GGA	p.G98G	FKBP8_uc002nji.1_5'UTR|FKBP8_uc010xqi.1_Silent_p.G127G|FKBP8_uc002njj.1_Silent_p.G98G|FKBP8_uc002njl.1_Silent_p.G98G|FKBP8_uc002njm.1_Silent_p.G98G|FKBP8_uc010ebr.1_Intron|FKBP8_uc002njn.2_RNA	NM_012181	NP_036313	Q14318	FKBP8_HUMAN	FK506-binding protein 8	98					apoptosis|interspecies interaction between organisms|intracellular signal transduction|protein folding	integral to endoplasmic reticulum membrane|mitochondrial membrane	FK506 binding|peptidyl-prolyl cis-trans isomerase activity|protein binding			ovary(1)	1						ACAGCCCGTTCCCTGCCAGGG	0.662		NaN											0	0	0	0.00361	0	66	84									
SFRS14	10147	broad.mit.edu	37	19	19136463	19136463	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:19136463G>A	uc002nkx.2	-	3	840	c.694C>T	c.(694-696)CAG>TAG	p.Q232*	SFRS14_uc002nkz.1_Nonsense_Mutation_p.Q246*|SFRS14_uc002nla.1_Nonsense_Mutation_p.Q232*|SFRS14_uc002nlb.2_Nonsense_Mutation_p.Q232*|SFRS14_uc010xqk.1_Intron	NM_014884	NP_055699	Q8IX01	SUGP2_HUMAN	splicing factor, arginine/serine-rich 14	232					mRNA processing|RNA splicing	nucleus	RNA binding				0			OV - Ovarian serous cystadenocarcinoma(5;3.05e-05)|Epithelial(12;0.00161)			AGCAGGCCCTGAGTCTCCCCC	0.522		NaN											0	0	0	0.004878	0	36	37									
ZNF682	91120	broad.mit.edu	37	19	20118011	20118011	+	Silent	SNP	C	C	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:20118011C>A	uc002noq.2	-	4	423	c.300G>T	c.(298-300)CTG>CTT	p.L100L	ZNF682_uc002noo.2_Silent_p.L68L|ZNF682_uc002nop.2_Silent_p.L68L|ZNF682_uc010eck.2_Silent_p.L24L	NM_033196	NP_149973	O95780	ZN682_HUMAN	zinc finger protein 682 isoform 1	100					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2						CATATCTTCTCAGTATCACTT	0.358		NaN											1	0	7.48243e-07	0.006214	7.64051e-07	9	5									
ANKRD27	84079	broad.mit.edu	37	19	33096819	33096819	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:33096819C>G	uc002ntn.1	-	24	2571	c.2415G>C	c.(2413-2415)AAG>AAC	p.K805N		NM_032139	NP_115515	Q96NW4	ANR27_HUMAN	ankyrin repeat domain 27 (VPS9 domain)	805	ANK 9.				early endosome to late endosome transport	early endosome|lysosome	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(2)|skin(2)|pancreas(1)	5	Esophageal squamous(110;0.137)					TGAGGTCCTTCTTATTGGGTT	0.512		NaN											0	0	0	0.00874	0	41	40									
GPI	2821	broad.mit.edu	37	19	34868692	34868692	+	Missense_Mutation	SNP	G	G	A	rs148548669		TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:34868692G>A	uc002nvg.1	+	6	642	c.539G>A	c.(538-540)CGC>CAC	p.R180H	GPI_uc002nvf.2_Missense_Mutation_p.R219H|GPI_uc010xrv.1_Missense_Mutation_p.R191H|GPI_uc010xrw.1_Missense_Mutation_p.R152H|GPI_uc010edl.1_Missense_Mutation_p.R180H	NM_000175	NP_000166	P06744	G6PI_HUMAN	glucose phosphate isomerase	180					angiogenesis|gluconeogenesis|glycolysis|hemostasis|humoral immune response	cytosol|extracellular space|nucleus|plasma membrane	cytokine activity|glucose-6-phosphate isomerase activity|growth factor activity			ovary(1)|kidney(1)	2	Esophageal squamous(110;0.162)					GGAGGTCCCCGCGTCTGGTAT	0.532		NaN											0	0	0	0.005524	0	34	53									
LRFN1	57622	broad.mit.edu	37	19	39798949	39798949	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:39798949G>C	uc002okw.2	-	2	1640	c.1640C>G	c.(1639-1641)TCG>TGG	p.S547W		NM_020862	NP_065913	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III	547	Helical; (Potential).					cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				ovary(2)	2	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			GACGAGGACCGAGGCGACGAT	0.667		NaN											0	0	0	0.008291	0	11	34									
LRFN1	57622	broad.mit.edu	37	19	39804928	39804928	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:39804928C>T	uc002okw.2	-	1	1049	c.1049G>A	c.(1048-1050)CGG>CAG	p.R350Q		NM_020862	NP_065913	Q9P244	LRFN1_HUMAN	leucine rich repeat and fibronectin type III	350	Ig-like.|Extracellular (Potential).					cell junction|integral to membrane|postsynaptic density|postsynaptic membrane				ovary(2)	2	all_cancers(60;1.85e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;6.4e-07)|Ovarian(47;0.0512)		Epithelial(26;1.96e-27)|all cancers(26;2.05e-24)|Lung(45;0.000278)|LUSC - Lung squamous cell carcinoma(53;0.000335)			CCCGTCCCCCCGGACCCGGGT	0.692		NaN											0	0	0	0.001984	0	7	16									
PSG1	5669	broad.mit.edu	37	19	43372352	43372352	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:43372352G>A	uc002ovb.2	-	5	1282	c.1144C>T	c.(1144-1146)CGC>TGC	p.R382C	PSG3_uc002ouf.2_Intron|PSG1_uc002oug.1_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG1_uc002oun.2_Intron|PSG1_uc002our.1_Missense_Mutation_p.R382C|PSG1_uc010eio.1_Missense_Mutation_p.R382C|PSG1_uc002oux.1_Missense_Mutation_p.R311C|PSG1_uc002ouy.1_Missense_Mutation_p.R289C|PSG1_uc002ouz.1_Missense_Mutation_p.R382C|PSG1_uc002ova.1_Missense_Mutation_p.R289C|PSG1_uc002ovc.2_Missense_Mutation_p.R289C|PSG1_uc002ovd.1_Missense_Mutation_p.R382C	NM_006905	NP_008836	P11464	PSG1_HUMAN	pregnancy specific beta-1-glycoprotein 1	382	Ig-like C2-type 3.				female pregnancy	extracellular region				ovary(2)	2		Prostate(69;0.00682)				GTAATATGGCGGATAAAGAGC	0.463		NaN											0	0	0	0.00361	0	87	198									
ZNF226	7769	broad.mit.edu	37	19	44680638	44680638	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:44680638C>G	uc002oyp.2	+	6	1367	c.1223C>G	c.(1222-1224)TCC>TGC	p.S408C	ZNF226_uc002oyq.2_Missense_Mutation_p.S291C|ZNF226_uc002oyr.2_Missense_Mutation_p.S291C|ZNF226_uc010ejg.2_3'UTR|ZNF226_uc002oys.2_Missense_Mutation_p.S408C|ZNF226_uc002oyt.2_Missense_Mutation_p.S408C	NM_001032373	NP_001027545	Q9NYT6	ZN226_HUMAN	zinc finger protein 226 isoform a	408	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)|all_neural(266;0.202)				CATCTTCAATCCCATCAAAGA	0.443		NaN											0	0	0	0.00278	0	24	33									
APOC1	341	broad.mit.edu	37	19	45418151	45418151	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:45418151G>A	uc002pac.1	+	3	255	c.3G>A	c.(1-3)ATG>ATA	p.M1I	APOC1_uc002pad.1_Missense_Mutation_p.M1I|APOC1_uc002pae.1_Missense_Mutation_p.M1I|APOC1_uc002paf.1_5'Flank	NM_001645	NP_001636	P02654	APOC1_HUMAN	apolipoprotein C-I precursor	1					cholesterol efflux|chylomicron remnant clearance|high-density lipoprotein particle remodeling|lipoprotein metabolic process|negative regulation of cholesterol transport|negative regulation of fatty acid biosynthetic process|negative regulation of lipoprotein lipase activity|negative regulation of phosphatidylcholine catabolic process|negative regulation of receptor-mediated endocytosis|negative regulation of very-low-density lipoprotein particle clearance|phospholipid efflux|positive regulation of cholesterol esterification|very-low-density lipoprotein particle assembly|very-low-density lipoprotein particle clearance	chylomicron|endoplasmic reticulum|high-density lipoprotein particle|very-low-density lipoprotein particle	fatty acid binding|phosphatidylcholine binding|phosphatidylcholine-sterol O-acyltransferase activator activity|phospholipase inhibitor activity				0	Lung NSC(12;0.0018)|all_lung(12;0.00481)	Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00327)|Epithelial(262;0.174)		GCCTCGCCATGAGGCTCTTCC	0.607		NaN											0	0	0	0.000978	0	10	29									
GLTSCR1	29998	broad.mit.edu	37	19	48204667	48204667	+	Silent	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:48204667C>T	uc002phh.3	+	15	3872	c.3678C>T	c.(3676-3678)CCC>CCT	p.P1226P	GLTSCR1_uc002phi.3_Silent_p.P984P	NM_015711	NP_056526	Q9NZM4	GSCR1_HUMAN	glioma tumor suppressor candidate region gene 1	1226							protein binding			pancreas(3)	3		all_cancers(25;1.8e-07)|all_lung(116;5.73e-06)|Lung NSC(112;9.69e-06)|all_epithelial(76;2.42e-05)|all_neural(266;0.0332)|Ovarian(192;0.086)		all cancers(93;0.000358)|OV - Ovarian serous cystadenocarcinoma(262;0.000576)|Epithelial(262;0.0212)|GBM - Glioblastoma multiforme(486;0.0355)		GCCACGGCCCCCTGTCGTCTT	0.692		NaN											0	0	0	0.001168	0	6	11									
LRRC4B	94030	broad.mit.edu	37	19	51021654	51021654	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:51021654G>A	uc002pss.2	-	3	1453	c.1316C>T	c.(1315-1317)ACG>ATG	p.T439M		NM_001080457	NP_001073926	Q9NT99	LRC4B_HUMAN	leucine rich repeat containing 4B precursor	439	Extracellular (Potential).|Ig-like C2-type.					cell junction|integral to membrane|presynaptic membrane				central_nervous_system(1)|skin(1)	2		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00284)|GBM - Glioblastoma multiforme(134;0.0188)		GGCTGAGTTCGTCACCATGCA	0.517		NaN											0	0	0	0.002445	0	29	48									
KLK15	55554	broad.mit.edu	37	19	51329142	51329142	+	Silent	SNP	G	G	A	rs137922291		TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:51329142G>A	uc002ptl.2	-	5	712	c.681C>T	c.(679-681)GAC>GAT	p.D227D	KLK1_uc002ptk.1_5'Flank|KLK1_uc010ycg.1_5'Flank|KLK15_uc002ptm.2_Silent_p.D142D|KLK15_uc002ptn.2_3'UTR|KLK15_uc002pto.2_Silent_p.D226D|KLK15_uc010ych.1_RNA|KLK15_uc010yci.1_3'UTR|KLK15_uc010eod.2_RNA	NM_017509	NP_059979	Q9H2R5	KLK15_HUMAN	kallikrein-related peptidase 15 isoform 4	227	Peptidase S1.				proteolysis	extracellular region	serine-type endopeptidase activity			lung(1)|breast(1)	2		all_neural(266;0.057)		OV - Ovarian serous cystadenocarcinoma(262;0.00758)|GBM - Glioblastoma multiforme(134;0.0143)		CACAAGGGACGTCACCCCAGG	0.557		NaN											0	0	0	0.00499	0	16	28									
CNOT3	4849	broad.mit.edu	37	19	54647809	54647809	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:54647809G>T	uc002qdj.1	+	6	637	c.326G>T	c.(325-327)GGC>GTC	p.G109V	CNOT3_uc010yel.1_Missense_Mutation_p.G109V|CNOT3_uc002qdi.2_Missense_Mutation_p.G22V|CNOT3_uc002qdk.1_Missense_Mutation_p.G109V|CNOT3_uc010ere.1_RNA	NM_014516	NP_055331	O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	109					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GAGGGCCTGGGCCTGGCCCAG	0.547		NaN											1	0	2.37509e-13	0.010504	2.48656e-13	22	55									
TNNT1	7138	broad.mit.edu	37	19	55649415	55649415	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:55649415C>T	uc002qjb.3	-	10	504	c.415G>A	c.(415-417)GAG>AAG	p.E139K	TNNT1_uc002qiz.3_Missense_Mutation_p.E69K|TNNT1_uc002qja.3_Missense_Mutation_p.E69K|TNNT1_uc002qjc.3_Missense_Mutation_p.E139K|TNNT1_uc002qje.3_Missense_Mutation_p.E128K|TNNT1_uc002qjd.3_Missense_Mutation_p.E128K|TNNT1_uc002qjf.2_Missense_Mutation_p.E135K	NM_003283	NP_003274	P13805	TNNT1_HUMAN	troponin T1, skeletal, slow isoform a	139					muscle filament sliding|negative regulation of muscle contraction	cytosol|troponin complex	tropomyosin binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.047)		TTCTTGGCCTCTTCCTCTTCC	0.567		NaN											0	0	0	0.00361	0	43	79									
ZNF814	730051	broad.mit.edu	37	19	58385546	58385546	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr19:58385546G>T	uc002qqo.2	-	3	1484	c.1212C>A	c.(1210-1212)GAC>GAA	p.D404E	ZNF814_uc002qqk.2_Intron|ZNF814_uc010yhl.1_Intron	NM_001144989	NP_001138461	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	404					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding				0						AATGTTTTTTGTCAGTGTGAA	0.393		NaN											1	0	0.004672	0.004672	0.00468817	3	16									
DDX1	1653	broad.mit.edu	37	2	15753407	15753407	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:15753407G>C	uc002rce.2	+	14	1304	c.1016G>C	c.(1015-1017)GGA>GCA	p.G339A	DDX1_uc010yjq.1_Missense_Mutation_p.G247A	NM_004939	NP_004930	Q92499	DDX1_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 1	339	Necessary for interaction with RELA.|Helicase ATP-binding.				DNA duplex unwinding|double-strand break repair|multicellular organismal development|regulation of transcription, DNA-dependent|regulation of translational initiation|spliceosome assembly|transcription, DNA-dependent	cleavage body|stress granule|tRNA-splicing ligase complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|DNA/RNA helicase activity|exonuclease activity|poly(A) RNA binding|protein binding|RNA helicase activity|transcription cofactor activity			central_nervous_system(2)|upper_aerodigestive_tract(1)|ovary(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.197)	all_epithelial(98;2.96e-07)|Acute lymphoblastic leukemia(84;4.24e-05)|Ovarian(717;0.0694)	GBM - Glioblastoma multiforme(3;0.00969)	Epithelial(75;4.35e-05)|OV - Ovarian serous cystadenocarcinoma(76;0.133)		TTGGAAAATGGAGTAAGTTGT	0.323		NaN											0	0	0	0.004482	0	8	28									
ITSN2	50618	broad.mit.edu	37	2	24522785	24522785	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:24522785C>G	uc002rfe.2	-	12	1595	c.1337G>C	c.(1336-1338)AGA>ACA	p.R446T	ITSN2_uc002rff.2_Missense_Mutation_p.R446T|ITSN2_uc002rfg.2_Missense_Mutation_p.R446T|ITSN2_uc010eyd.2_Missense_Mutation_p.R471T	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	446	Potential.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AACCTCTCGTCTTTCTATGTC	0.289		NaN											0	0	0	0.003163	0	14	60									
ITSN2	50618	broad.mit.edu	37	2	24522905	24522905	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:24522905C>T	uc002rfe.2	-	12	1475	c.1217G>A	c.(1216-1218)CGA>CAA	p.R406Q	ITSN2_uc002rff.2_Missense_Mutation_p.R406Q|ITSN2_uc002rfg.2_Missense_Mutation_p.R406Q|ITSN2_uc010eyd.2_Missense_Mutation_p.R431Q	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	406	Potential.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTCTGTTTTCGTTCCCACTC	0.453		NaN											0	0	0	0.002445	0	30	114									
ITSN2	50618	broad.mit.edu	37	2	24522915	24522915	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:24522915C>T	uc002rfe.2	-	12	1465	c.1207G>A	c.(1207-1209)GAG>AAG	p.E403K	ITSN2_uc002rff.2_Missense_Mutation_p.E403K|ITSN2_uc002rfg.2_Missense_Mutation_p.E403K|ITSN2_uc010eyd.2_Missense_Mutation_p.E428K	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	403	Potential.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CGTTCCCACTCTTCCTTTTCT	0.453		NaN											0	0	0	0.004878	0	32	118									
ITSN2	50618	broad.mit.edu	37	2	24523032	24523032	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:24523032C>G	uc002rfe.2	-	12	1348	c.1090G>C	c.(1090-1092)GAG>CAG	p.E364Q	ITSN2_uc002rff.2_Missense_Mutation_p.E364Q|ITSN2_uc002rfg.2_Missense_Mutation_p.E364Q|ITSN2_uc010eyd.2_Missense_Mutation_p.E389Q	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	364	Potential.				endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CGTTTGTCCTCAAAAGTAACT	0.448		NaN											0	0	0	0.00874	0	39	55									
NCOA1	8648	broad.mit.edu	37	2	24930608	24930608	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:24930608G>T	uc002rfk.2	+	11	2527	c.2269G>T	c.(2269-2271)GAG>TAG	p.E757*	NCOA1_uc010eye.2_Nonsense_Mutation_p.E757*|NCOA1_uc002rfi.2_Nonsense_Mutation_p.E606*|NCOA1_uc002rfj.2_Nonsense_Mutation_p.E757*|NCOA1_uc002rfl.2_Nonsense_Mutation_p.E757*	NM_003743	NP_003734	Q15788	NCOA1_HUMAN	nuclear receptor coactivator 1 isoform 1	757									PAX3/NCOA1(8)	soft_tissue(8)|ovary(1)|lung(1)|skin(1)	11	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGATAAAGATGAGAAAGATTT	0.378		NaN	T	PAX3	alveolar rhadomyosarcoma								1	0	6.42651e-13	0.000978	6.70392e-13	12	25									
GCKR	2646	broad.mit.edu	37	2	27746223	27746223	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:27746223G>C	uc002rky.2	+	19	1861	c.1795G>C	c.(1795-1797)GAG>CAG	p.E599Q	GCKR_uc010ezd.2_Missense_Mutation_p.E597Q|GCKR_uc010ylu.1_Missense_Mutation_p.E409Q	NM_001486	NP_001477	Q14397	GCKR_HUMAN	glucokinase regulatory protein	599					carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)					TTCTGTCTGTGAGGCTGTCAG	0.597		NaN											0	0	0	0.006214	0	10	37									
GCKR	2646	broad.mit.edu	37	2	27746258	27746258	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:27746258G>C	uc002rky.2	+	19	1896	c.1830G>C	c.(1828-1830)CAG>CAC	p.Q610H	GCKR_uc010ezd.2_Missense_Mutation_p.Q608H|GCKR_uc010ylu.1_Missense_Mutation_p.Q420H	NM_001486	NP_001477	Q14397	GCKR_HUMAN	glucokinase regulatory protein	610					carbohydrate metabolic process|glucose transport|negative regulation of glucokinase activity|positive regulation of gene expression|protein import into nucleus, translocation|regulation of glucose transport|response to fructose stimulus|transmembrane transport|triglyceride homeostasis|urate metabolic process	cytosol|nucleoplasm	fructose-6-phosphate binding|protein binding			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)					GGCCAGGTCAGAAGCGCACTG	0.612		NaN											0	0	0	0.001368	0	13	54									
SUPT7L	9913	broad.mit.edu	37	2	27884012	27884012	+	Silent	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:27884012C>T	uc002rlh.1	-	3	601	c.258G>A	c.(256-258)CAG>CAA	p.Q86Q	SUPT7L_uc002rli.1_Silent_p.Q86Q|SUPT7L_uc010ymf.1_Intron|SUPT7L_uc002rlj.1_Silent_p.Q84Q|SUPT7L_uc010ezh.1_Silent_p.Q84Q|SLC4A1AP_uc002rlk.3_5'Flank	NM_014860	NP_055675	O94864	ST65G_HUMAN	SPTF-associated factor 65 gamma	86					histone H3 acetylation|maintenance of protein location in nucleus|regulation of transcription, DNA-dependent|transcription, DNA-dependent	STAGA complex	transcription coactivator activity			skin(2)	2	Acute lymphoblastic leukemia(172;0.155)					GCTGCTGATTCTGGGCCTGAG	0.517		NaN											0	0	0	0.003163	0	16	47									
CAPN13	92291	broad.mit.edu	37	2	30965216	30965216	+	Silent	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:30965216G>A	uc002rnn.2	-	13	1631	c.1455C>T	c.(1453-1455)AGC>AGT	p.S485S	CAPN13_uc002rnm.2_RNA|CAPN13_uc002rno.2_Silent_p.S39S	NM_144575	NP_653176	Q6MZZ7	CAN13_HUMAN	calpain 13	485					proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			large_intestine(1)|ovary(1)	2	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.155)					TGAAATGGCTGCTCAGGTGCC	0.532		NaN											0	0	0	0.000602	0	5	8									
VPS54	51542	broad.mit.edu	37	2	64141357	64141357	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:64141357C>G	uc002scq.2	-	17	2456	c.2293G>C	c.(2293-2295)GTT>CTT	p.V765L	VPS54_uc002scp.2_Missense_Mutation_p.V753L|VPS54_uc002scn.2_5'UTR|VPS54_uc002sco.2_Missense_Mutation_p.V250L|VPS54_uc010fct.2_Missense_Mutation_p.V612L	NM_016516	NP_057600	Q9P1Q0	VPS54_HUMAN	vacuolar protein sorting 54 isoform 1	765					protein transport|retrograde transport, endosome to Golgi						0						TCAGTAGTAACAGATGGGATG	0.348		NaN											0	0	0	0.002836	0	31	48									
REG1B	5968	broad.mit.edu	37	2	79312402	79312402	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:79312402C>G	uc002sny.2	-	6	553	c.441G>C	c.(439-441)AAG>AAC	p.K147N		NM_006507	NP_006498	P48304	REG1B_HUMAN	regenerating islet-derived 1 beta precursor	147	C-type lectin.				cell proliferation	extracellular region	sugar binding			central_nervous_system(1)|skin(1)	2						CCTTCCATTTCTTGAATCCTA	0.403		NaN											0	0	0	0.006214	0	9	18									
MRPS5	64969	broad.mit.edu	37	2	95766234	95766234	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:95766234T>A	uc002sub.2	-	10	1134	c.916A>T	c.(916-918)AAG>TAG	p.K306*	MRPS5_uc002suc.2_RNA	NM_031902	NP_114108	P82675	RT05_HUMAN	mitochondrial ribosomal protein S5	306					translation	mitochondrion|ribosome	protein binding|RNA binding|structural constituent of ribosome			ovary(2)|central_nervous_system(1)	3						GGTTGTTTCTTCATCTTGATA	0.323		NaN											0	0	0	0.006122	0	17	39									
LCT	3938	broad.mit.edu	37	2	136562346	136562346	+	Silent	SNP	G	G	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:136562346G>T	uc002tuu.1	-	10	4466	c.4455C>A	c.(4453-4455)ATC>ATA	p.I1485I		NM_002299	NP_002290	P09848	LPH_HUMAN	lactase-phlorizin hydrolase preproprotein	1485	Extracellular (Potential).|4.|4 X approximate repeats.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|integral to plasma membrane|membrane fraction	cation binding|glycosylceramidase activity|lactase activity			ovary(7)|central_nervous_system(2)|skin(2)|pancreas(1)|lung(1)	13				BRCA - Breast invasive adenocarcinoma(221;0.169)		CCTGGGGCTGGATGCTGGCGG	0.562		NaN											1	0	4.96729e-08	0.008871	5.09016e-08	18	41									
NEB	4703	broad.mit.edu	37	2	152553231	152553231	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:152553231G>C	uc010fnx.2	-	17	1680	c.1489C>G	c.(1489-1491)CCA>GCA	p.P497A	NEB_uc010fny.1_Missense_Mutation_p.P51A	NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	497					muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		GTCTTATCTGGATGGACTTTG	0.458		NaN											0	0	0	0.006214	0	10	26									
KBTBD10	10324	broad.mit.edu	37	2	170371102	170371102	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:170371102G>A	uc002ueu.1	+	2	1206	c.1129G>A	c.(1129-1131)GAA>AAA	p.E377K	KBTBD10_uc010zdh.1_Missense_Mutation_p.E315K	NM_006063	NP_006054	O60662	KBTBA_HUMAN	kelch repeat and BTB (POZ) domain containing 10	377	Kelch 1.				striated muscle contraction	centrosome|nucleolus|plasma membrane|pseudopodium|ruffle					0						CATAGCATCTGAATGGGTTGG	0.398		NaN											0	0	0	0.004656	0	24	33									
NFE2L2	4780	broad.mit.edu	37	2	178098799	178098799	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08			T	A	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:178098799T>A	uc002ulh.3	-	2	801	c.246A>T	c.(244-246)GAA>GAT	p.E82D	NFE2L2_uc002ulg.3_Missense_Mutation_p.E66D|NFE2L2_uc010zfa.1_Missense_Mutation_p.E66D|NFE2L2_uc002uli.3_Missense_Mutation_p.E66D|NFE2L2_uc010fra.2_Missense_Mutation_p.E66D|NFE2L2_uc010frb.2_Missense_Mutation_p.E66D	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	82					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TTGGGAGAAATTCACCTGTCT	0.433		NaN	Mis		NSCLC|HNSCC					HNSCC(56;0.16)			0	0	0	0.010504	0	20	33									
NFE2L2	4780	broad.mit.edu	37	2	178098810	178098810	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:178098810C>G	uc002ulh.3	-	2	790	c.235G>C	c.(235-237)GAG>CAG	p.E79Q	NFE2L2_uc002ulg.3_Missense_Mutation_p.E63Q|NFE2L2_uc010zfa.1_Missense_Mutation_p.E63Q|NFE2L2_uc002uli.3_Missense_Mutation_p.E63Q|NFE2L2_uc010fra.2_Missense_Mutation_p.E63Q|NFE2L2_uc010frb.2_Missense_Mutation_p.E63Q	NM_006164	NP_006155	Q16236	NF2L2_HUMAN	nuclear factor erythroid 2-like 2 isoform 1	79					transcription from RNA polymerase II promoter	centrosome|cytosol|nucleus|plasma membrane	protein dimerization activity|protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Epithelial(96;0.00442)|OV - Ovarian serous cystadenocarcinoma(117;0.00739)|all cancers(119;0.0195)|LUSC - Lung squamous cell carcinoma(2;0.036)|Lung(16;0.0935)			TCACCTGTCTCTTCATCTAGT	0.443		NaN	Mis		NSCLC|HNSCC					HNSCC(56;0.16)			0	0	0	0.004007	0	16	34									
DUSP28	285193	broad.mit.edu	37	2	241500413	241500413	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:241500413G>C	uc002vzg.2	+	1	943	c.312G>C	c.(310-312)AAG>AAC	p.K104N	ANKMY1_uc002vzd.1_5'Flank|ANKMY1_uc010fze.1_5'Flank|ANKMY1_uc002vze.2_5'Flank|ANKMY1_uc002vzf.2_5'Flank|DUSP28_uc002vzh.2_Missense_Mutation_p.K104N	NM_001033575	NP_001028747	Q4G0W2	DUS28_HUMAN	dual specificity phosphatase 28	104	Tyrosine-protein phosphatase.						protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			upper_aerodigestive_tract(1)	1		all_epithelial(40;2.79e-15)|Breast(86;2.41e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0335)|Lung NSC(271;0.106)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;2.16e-31)|all cancers(36;5.56e-29)|OV - Ovarian serous cystadenocarcinoma(60;7.57e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.06e-06)|Lung(119;0.00164)|Colorectal(34;0.00468)|LUSC - Lung squamous cell carcinoma(224;0.00802)|COAD - Colon adenocarcinoma(134;0.0311)		TCTACTGCAAGAACGGCCGCA	0.741		NaN											0	0	0	0.009096	0	4	12									
KCNS1	3787	broad.mit.edu	37	20	43723922	43723922	+	Silent	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr20:43723922G>A	uc002xnc.2	-	5	1567	c.1170C>T	c.(1168-1170)TTC>TTT	p.F390F	KCNS1_uc002xnd.2_Silent_p.F390F	NM_002251	NP_002242	Q96KK3	KCNS1_HUMAN	potassium voltage-gated channel	390	Helical; Name=Segment S5; (Potential).					voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity|protein binding				0		Myeloproliferative disorder(115;0.0122)				CCACACCAGAGAACACTGACA	0.567		NaN											0	0	0	0.00245	0	14	40									
C20orf43	51507	broad.mit.edu	37	20	55088466	55088466	+	Silent	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr20:55088466G>A	uc002xxt.2	+	6	680	c.573G>A	c.(571-573)CTG>CTA	p.L191L	C20orf43_uc010zzf.1_Silent_p.L221L|C20orf43_uc002xxu.2_Silent_p.L191L|C20orf43_uc002xxv.2_Silent_p.L191L|GCNT7_uc010zzg.1_Intron	NM_016407	NP_057491	Q9BY42	CT043_HUMAN	hypothetical protein LOC51507	191										ovary(1)	1			Colorectal(105;0.202)			AGAGAAGGCTGAGAGCGAAGC	0.562		NaN											0	0	0	0.004672	0	3	14									
TFAP2C	7022	broad.mit.edu	37	20	55206428	55206428	+	Silent	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr20:55206428G>A	uc002xya.2	+	2	459	c.216G>A	c.(214-216)TCG>TCA	p.S72S	TFAP2C_uc010zzi.1_5'UTR	NM_003222	NP_003213	Q92754	AP2C_HUMAN	transcription factor AP-2 gamma	72	Gln/Pro-rich (transactivation domain).				cell-cell signaling|male gonad development|regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein dimerization activity|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)	1			Colorectal(105;0.229)			ACTCCCAGTCGGCCGACCCCT	0.701		NaN											0	0	0	0.003163	0	15	34									
NPEPL1	79716	broad.mit.edu	37	20	57268967	57268967	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr20:57268967C>G	uc010zzs.1	+	2	420	c.325C>G	c.(325-327)CGC>GGC	p.R109G	NPEPL1_uc010zzr.1_Missense_Mutation_p.R61G|NPEPL1_uc002xzn.2_RNA|NPEPL1_uc010gjo.1_Missense_Mutation_p.R81G|NPEPL1_uc002xzp.2_Translation_Start_Site	NM_024663	NP_078939	Q8NDH3	PEPL1_HUMAN	aminopeptidase-like 1	109					proteolysis	cytoplasm	aminopeptidase activity|manganese ion binding|metalloexopeptidase activity				0	all_lung(29;0.0175)		BRCA - Breast invasive adenocarcinoma(13;2.88e-09)|Colorectal(105;0.109)			CGGAGCGCATCGCTGCATTGT	0.701		NaN											0	0	0	0.00308	0	8	17									
HRH3	11255	broad.mit.edu	37	20	60794805	60794805	+	Silent	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr20:60794805G>C	uc002ycf.2	-	1	519	c.222C>G	c.(220-222)CTC>CTG	p.L74L	HRH3_uc002ycg.2_Silent_p.L74L|HRH3_uc002ych.2_Silent_p.L74L|HRH3_uc002yci.2_Silent_p.L74L	NM_007232	NP_009163	Q9Y5N1	HRH3_HUMAN	histamine receptor H3	74	Helical; Name=2; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|neurotransmitter secretion	integral to plasma membrane	histamine receptor activity				0	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;7.08e-07)		Histamine Phosphate(DB00667)	TGGCGAGGTTGAGCAGGAAGA	0.682		NaN											0	0	0	0.001882	0	18	46									
PRDM15	63977	broad.mit.edu	37	21	43298877	43298877	+	Missense_Mutation	SNP	G	G	A	rs75817094		TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr21:43298877G>A	uc002yzq.1	-	3	451	c.340C>T	c.(340-342)CGG>TGG	p.R114W	PRDM15_uc002yzo.2_Intron|PRDM15_uc002yzp.2_Intron|PRDM15_uc002yzr.1_Intron	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	114					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGCTGTACCCGAGGGCGGGGG	0.493		NaN											0	0	0	0.001855	0	12	6									
SLC25A18	83733	broad.mit.edu	37	22	18070755	18070755	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr22:18070755G>A	uc002zmp.1	+	9	1134	c.640G>A	c.(640-642)GAG>AAG	p.E214K	SLC25A18_uc010gqx.2_Missense_Mutation_p.E214K|SLC25A18_uc002zmq.1_Missense_Mutation_p.E214K	NM_031481	NP_113669	Q9H1K4	GHC2_HUMAN	solute carrier	214						integral to membrane|mitochondrial inner membrane	binding|symporter activity				0				Lung(27;0.124)	L-Glutamic Acid(DB00142)	GGGGTTCAACGAGCTCGCCGG	0.532		NaN											0	0	0	0.007835	0	42	69									
CHEK2	11200	broad.mit.edu	37	22	29091193	29091193	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr22:29091193G>C	uc003adu.1	-	12	1369	c.1297C>G	c.(1297-1299)CAA>GAA	p.Q433E	CHEK2_uc003ads.1_Missense_Mutation_p.Q212E|CHEK2_uc010gvh.1_Missense_Mutation_p.Q342E|CHEK2_uc010gvi.1_Intron|CHEK2_uc010gvj.1_Intron|CHEK2_uc003adr.1_RNA|CHEK2_uc010gvk.1_RNA|CHEK2_uc003adt.1_Missense_Mutation_p.Q476E|CHEK2_uc003adv.1_Missense_Mutation_p.Q404E|CHEK2_uc003adw.1_Missense_Mutation_p.Q433E|CHEK2_uc003adx.1_Missense_Mutation_p.Q212E|CHEK2_uc003ady.1_Missense_Mutation_p.Q422E|CHEK2_uc003adz.1_Missense_Mutation_p.Q237E	NM_007194	NP_009125	O96017	CHK2_HUMAN	protein kinase CHK2 isoform a	433	Protein kinase.				cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|stomach(1)|ovary(1)|lung(1)	20						AGTGACACTTGAGTCCTATGC	0.413		NaN	F			breast 		Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|CHEK2-associated_cancer				0	0	0	0.000978	0	11	28									
CHEK2	11200	broad.mit.edu	37	22	29091207	29091207	+	Missense_Mutation	SNP	G	G	A	rs137853011	byFrequency	TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr22:29091207G>A	uc003adu.1	-	12	1355	c.1283C>T	c.(1282-1284)TCT>TTT	p.S428F	CHEK2_uc003ads.1_Missense_Mutation_p.S207F|CHEK2_uc010gvh.1_Missense_Mutation_p.S337F|CHEK2_uc010gvi.1_Intron|CHEK2_uc010gvj.1_Intron|CHEK2_uc003adr.1_RNA|CHEK2_uc010gvk.1_RNA|CHEK2_uc003adt.1_Missense_Mutation_p.S471F|CHEK2_uc003adv.1_Missense_Mutation_p.S399F|CHEK2_uc003adw.1_Missense_Mutation_p.S428F|CHEK2_uc003adx.1_Missense_Mutation_p.S207F|CHEK2_uc003ady.1_Intron|CHEK2_uc003adz.1_Missense_Mutation_p.S232F	NM_007194	NP_009125	O96017	CHK2_HUMAN	protein kinase CHK2 isoform a	428	Protein kinase.		S -> F (increases breast cancer risk approximately 2-fold among Ashkenazi Jewish women).		cell cycle|DNA damage checkpoint|DNA damage response, signal transduction resulting in induction of apoptosis|replicative senescence	PML body	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(17)|stomach(1)|ovary(1)|lung(1)	20						CCTATGCTCAGAGAAAGGTGG	0.398		NaN	F			breast 		Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes	Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|CHEK2-associated_cancer				0	0	0	0.000978	0	11	29									
EP300	2033	broad.mit.edu	37	22	41556722	41556722	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr22:41556722C>G	uc003azl.3	+	20	4062	c.3667C>G	c.(3667-3669)CAA>GAA	p.Q1223E		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1223					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding	p.Y1198_L1243del(1)		haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						TTCCCAGCCTCAAACGTAAGT	0.388		NaN	T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.005443	0	26	41									
BRD1	23774	broad.mit.edu	37	22	50216812	50216812	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr22:50216812C>T	uc003biv.2	-	1	1641	c.1154G>A	c.(1153-1155)TGT>TAT	p.C385Y	BRD1_uc011arf.1_Translation_Start_Site|BRD1_uc011arg.1_Missense_Mutation_p.C385Y|BRD1_uc011arh.1_Missense_Mutation_p.C385Y|BRD1_uc003biu.3_Missense_Mutation_p.C385Y	NM_014577	NP_055392	O95696	BRD1_HUMAN	bromodomain containing protein 1	385					histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			pancreas(1)	1		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)		GTGGACATCACAGTAAGCGGT	0.542		NaN											0	0	0	0.00361	0	66	112									
TTLL8	164714	broad.mit.edu	37	22	50470355	50470355	+	Silent	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr22:50470355G>A	uc011ark.1	-	11	1467	c.1467C>T	c.(1465-1467)CAC>CAT	p.H489H		NM_001080447	NP_001073916			tubulin tyrosine ligase-like family, member 8											ovary(2)	2		all_cancers(38;3.44e-07)|all_epithelial(38;2.44e-06)|all_lung(38;0.00141)|Breast(42;0.00519)|Lung NSC(38;0.0199)|Ovarian(80;0.142)|Lung SC(80;0.162)		READ - Rectum adenocarcinoma(2;0.000882)|Colorectal(2;0.00311)|BRCA - Breast invasive adenocarcinoma(115;0.226)		CCTTCATGGCGTGGGCGATGG	0.642		NaN											0	0	0	0.00278	0	25	36									
PLXNB2	23654	broad.mit.edu	37	22	50717351	50717351	+	Silent	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr22:50717351C>T	uc003bkv.3	-	28	4585	c.4479G>A	c.(4477-4479)AAG>AAA	p.K1493K	PLXNB2_uc003bkt.1_Silent_p.K285K|PLXNB2_uc003bku.1_Silent_p.K478K	NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	1493	Cytoplasmic (Potential).				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GGTCAATGATCTTCTCCTTGA	0.642		NaN											0	0	0	0.001368	0	11	31									
MLH1	4292	broad.mit.edu	37	3	37056007	37056007	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr3:37056007G>C	uc003cgl.2	+	9	822	c.762G>C	c.(760-762)AAG>AAC	p.K254N	MLH1_uc011aye.1_Missense_Mutation_p.K13N|MLH1_uc011ayb.1_Missense_Mutation_p.K13N|MLH1_uc010hge.2_Missense_Mutation_p.K254N|MLH1_uc003cgn.3_Missense_Mutation_p.K13N|MLH1_uc011ayc.1_Missense_Mutation_p.K156N|MLH1_uc011ayd.1_Missense_Mutation_p.K13N|MLH1_uc003cgo.2_Missense_Mutation_p.K13N|MLH1_uc010hgg.1_5'UTR|MLH1_uc010hgh.1_Intron|MLH1_uc010hgi.1_5'UTR|MLH1_uc010hgj.1_Intron|MLH1_uc010hgk.2_5'UTR|MLH1_uc010hgl.1_5'UTR	NM_000249	NP_000240	P40692	MLH1_HUMAN	MutL protein homolog 1	254			Missing (in HNPCC2).		mismatch repair|somatic hypermutation of immunoglobulin genes	chiasma|MutLalpha complex|MutLbeta complex|synaptonemal complex	ATP binding|ATPase activity|protein binding	p.0?(1)		large_intestine(40)|haematopoietic_and_lymphoid_tissue(8)|ovary(6)|pancreas(5)|stomach(3)|central_nervous_system(3)|endometrium(3)|breast(3)|prostate(3)|skin(2)|NS(1)	77						ACTCAGTGAAGAAGTGCATCT	0.383		1	D|Mis|N|F|S		colorectal|endometrial|ovarian|CNS	colorectal|endometrial|ovarian|CNS		MMR	Lynch_syndrome|Muir-Torre_syndrome|Turcot_syndrome|Constitutional_Mismatch_Repair_Deficiency_Syndrome				0	0	0	0.006122	0	17	21									
COL7A1	1294	broad.mit.edu	37	3	48622525	48622525	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr3:48622525G>C	uc003ctz.2	-	32	3920	c.3919C>G	c.(3919-3921)CCA>GCA	p.P1307A		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	1307	Triple-helical region.|Interrupted collagenous region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GGGCTGCCTGGACGCCCATCT	0.682		NaN											0	0	0	0.006122	0	16	41									
COL7A1	1294	broad.mit.edu	37	3	48622544	48622544	+	Silent	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr3:48622544G>A	uc003ctz.2	-	32	3901	c.3900C>T	c.(3898-3900)TTC>TTT	p.F1300F		NM_000094	NP_000085	Q02388	CO7A1_HUMAN	alpha 1 type VII collagen precursor	1300	Triple-helical region.|Interrupted collagenous region.				cell adhesion|epidermis development	basement membrane|collagen type VII	protein binding|serine-type endopeptidase inhibitor activity			ovary(4)|breast(3)|skin(3)|central_nervous_system(1)	11				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		CTGCTCCAGGGAAGCCCTGAG	0.667		NaN											0	0	0	0.000978	0	12	37									
PPM1M	132160	broad.mit.edu	37	3	52282393	52282393	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr3:52282393C>G	uc003ddf.3	+	6	720	c.355C>G	c.(355-357)CTG>GTG	p.L119V	PPM1M_uc011bed.1_Missense_Mutation_p.L280V|PPM1M_uc010hmd.2_Missense_Mutation_p.L119V|PPM1M_uc003ddg.3_Missense_Mutation_p.L68V|PPM1M_uc003ddh.3_5'Flank			Q96MI6	PPM1M_HUMAN	RecName: Full=Protein phosphatase 1M;          EC=3.1.3.16; AltName: Full=Protein phosphatase 2C isoform eta;          Short=PP2C-eta;          Short=PP2CE;	119	PP2C-like.				protein dephosphorylation	nucleus	CTD phosphatase activity|manganese ion binding				0				BRCA - Breast invasive adenocarcinoma(193;2.4e-05)|Kidney(197;0.00171)|KIRC - Kidney renal clear cell carcinoma(197;0.00194)		GTTCACCCGACTGGAGTTCCC	0.592		NaN											0	0	0	0.004482	0	9	23									
C3orf63	23272	broad.mit.edu	37	3	56680888	56680888	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr3:56680888T>C	uc003did.3	-	14	1978	c.1877A>G	c.(1876-1878)AAT>AGT	p.N626S	C3orf63_uc003dic.3_Missense_Mutation_p.N230S|C3orf63_uc003die.3_Missense_Mutation_p.N626S	NM_015224	NP_056039	Q9UK61	CC063_HUMAN	retinoblastoma-associated protein 140 isoform b	626										ovary(3)|kidney(1)|central_nervous_system(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.0126)|Kidney(284;0.0147)		AAGTTTTCTATTTTCTTCAAA	0.299		NaN											0	0	0	0.004482	0	9	25									
PDE12	201626	broad.mit.edu	37	3	57543222	57543222	+	Silent	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr3:57543222G>A	uc003diw.3	+	1	1242	c.1116G>A	c.(1114-1116)GGG>GGA	p.G372G	PDE12_uc003div.2_Silent_p.G372G	NM_177966	NP_808881	Q6L8Q7	PDE12_HUMAN	phosphodiesterase 12	372							hydrolase activity				0				KIRC - Kidney renal clear cell carcinoma(284;0.011)|Kidney(284;0.0127)		GGCTCGAGGGGGTGTTTCGAA	0.547		NaN											0	0	0	0.008291	0	11	42									
FAM116A	201627	broad.mit.edu	37	3	57619051	57619051	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr3:57619051G>C	uc003dja.2	-	15	1365	c.1294C>G	c.(1294-1296)CAA>GAA	p.Q432E		NM_152678	NP_689891	Q8IWF6	F116A_HUMAN	hypothetical protein LOC201627	432										pancreas(1)	1				BRCA - Breast invasive adenocarcinoma(55;0.000621)|KIRC - Kidney renal clear cell carcinoma(284;0.0485)|Kidney(284;0.0607)		ATAACACTTTGAGCCTCAGAA	0.303		NaN											0	0	0	0.003163	0	14	33									
PSMD6	9861	broad.mit.edu	37	3	64009039	64009039	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr3:64009039G>C	uc003dma.1	-	1	82	c.57C>G	c.(55-57)ATC>ATG	p.I19M	PSMD6_uc003dlz.1_Translation_Start_Site|PSMD6_uc003dmb.1_Missense_Mutation_p.I19M|PSMD6_uc003dmc.1_Intron|PSMD6_uc003dmd.1_Intron	NM_014814	NP_055629	Q15008	PSMD6_HUMAN	proteasome (prosome, macropain) 26S subunit,	19					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	proteasome complex	ATPase activity|protein binding			central_nervous_system(1)|skin(1)	2		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000805)|Kidney(15;0.00188)|KIRC - Kidney renal clear cell carcinoma(15;0.00212)		GCAGCTGCGCGATACGCAAGT	0.672		NaN											0	0	0	0.001368	0	12	17									
IQCB1	9657	broad.mit.edu	37	3	121491473	121491473	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr3:121491473C>G	uc010hre.1	-	14	1713	c.1498G>C	c.(1498-1500)GAA>CAA	p.E500Q	IQCB1_uc003eek.2_Missense_Mutation_p.E367Q|IQCB1_uc010hrf.1_RNA	NM_001023570	NP_001018864	Q15051	IQCB1_HUMAN	IQ motif containing B1 isoform a	500					cilium assembly|maintenance of organ identity|photoreceptor cell maintenance	centrosome|photoreceptor connecting cilium	calmodulin binding				0				GBM - Glioblastoma multiforme(114;0.0983)		GCTCGCTCTTCTAGGGCCCTG	0.498		NaN											0	0	0	0.009718	0	41	84									
DIRC2	84925	broad.mit.edu	37	3	122598123	122598123	+	Silent	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr3:122598123C>T	uc003efw.3	+	9	1474	c.1335C>T	c.(1333-1335)TTC>TTT	p.F445F	DIRC2_uc010hrl.2_RNA|DIRC2_uc010hrm.2_Silent_p.F283F|uc003efx.1_RNA	NM_032839	NP_116228	Q96SL1	DIRC2_HUMAN	disrupted in renal carcinoma 2	445	Helical; (Potential).				transport	integral to membrane					0				GBM - Glioblastoma multiforme(114;0.0614)		TGTCTTGGTTCAACTGGTGCC	0.463		NaN											0	0	0	0.00361	0	103	189									
IFT122	55764	broad.mit.edu	37	3	129185821	129185821	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr3:129185821C>G	uc003emm.2	+	8	858	c.652C>G	c.(652-654)CTG>GTG	p.L218V	IFT122_uc003eml.2_Missense_Mutation_p.L269V|IFT122_uc003emn.2_Intron|IFT122_uc003emo.2_Intron|IFT122_uc003emp.2_Missense_Mutation_p.L68V|IFT122_uc010htc.2_Intron|IFT122_uc011bky.1_Intron|IFT122_uc003emq.2_Intron|IFT122_uc003emr.2_Intron|IFT122_uc011bla.1_Intron|IFT122_uc011bkx.1_Intron|IFT122_uc011bkz.1_Intron	NM_052989	NP_443715	Q9HBG6	IF122_HUMAN	WD repeat domain 10 isoform 2	218					camera-type eye morphogenesis|cilium morphogenesis|embryonic body morphogenesis|embryonic heart tube development|limb development|neural tube closure	microtubule basal body|photoreceptor connecting cilium				ovary(1)|skin(1)	2						CCCTTCCACTCTGAAGTCAGC	0.498		NaN											0	0	0	0.002836	0	33	64									
DNAJC13	23317	broad.mit.edu	37	3	132182552	132182552	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr3:132182552G>C	uc003eor.2	+	17	1848	c.1783G>C	c.(1783-1785)GAA>CAA	p.E595Q	DNAJC13_uc010htq.1_Missense_Mutation_p.E595Q	NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	595							heat shock protein binding			ovary(1)|breast(1)	2						AGGTGATAAAGAAATTGCTAC	0.383		NaN											0	0	0	0.004656	0	24	42									
XRN1	54464	broad.mit.edu	37	3	142144273	142144273	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr3:142144273C>T	uc003eus.2	-	4	581	c.514G>A	c.(514-516)GAG>AAG	p.E172K	XRN1_uc003eut.2_Missense_Mutation_p.E172K|XRN1_uc003euu.2_Missense_Mutation_p.E172K|XRN1_uc003euv.1_Missense_Mutation_p.E33K|XRN1_uc003euw.2_Missense_Mutation_p.E172K|XRN1_uc011bnh.1_Intron	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	172					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3						ATAATAACCTCATGGCCTGAG	0.279		NaN											0	0	0	0.00499	0	17	6									
KLHL24	54800	broad.mit.edu	37	3	183368537	183368537	+	Silent	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr3:183368537C>T	uc003flv.2	+	3	688	c.393C>T	c.(391-393)ATC>ATT	p.I131I	KLHL24_uc003flw.2_Silent_p.I131I|KLHL24_uc003flx.2_Silent_p.I131I	NM_017644	NP_060114	Q6TFL4	KLH24_HUMAN	DRE1 protein	131	BTB.					axon|cytoplasm|perikaryon				ovary(1)	1	all_cancers(143;2.88e-10)|Ovarian(172;0.0303)		all cancers(12;1.43e-42)|Epithelial(37;1.73e-36)|OV - Ovarian serous cystadenocarcinoma(80;8.75e-22)			AGGTGAAGATCACTACAGAGA	0.408		NaN											0	0	0	0.001984	0	6	137									
C3orf43	255798	broad.mit.edu	37	3	196236536	196236536	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr3:196236536C>G	uc003fws.2	-	2	212	c.55G>C	c.(55-57)GAC>CAC	p.D19H	C3orf43_uc003fwr.2_Missense_Mutation_p.D11H	NM_001077657	NP_001071125	Q147U7	CC043_HUMAN	hypothetical protein LOC255798	19	Potential.					integral to membrane				ovary(1)	1	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;2.13e-23)|all cancers(36;2e-21)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00298)		AGTTTGTGGTCTACTCTGTAG	0.373		NaN											0	0	0	0.00361	0	46	86									
FGFR3	2261	broad.mit.edu	37	4	1803568	1803568	+	Missense_Mutation	SNP	C	C	G	rs121913483		TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	RNASeq			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr4:1803568C>G	uc003gdr.3	+	7	1002	c.746C>G	c.(745-747)TCC>TGC	p.S249C	FGFR3_uc003gdu.2_Missense_Mutation_p.S249C|FGFR3_uc003gds.3_Missense_Mutation_p.S249C|FGFR3_uc003gdq.3_Missense_Mutation_p.S249C|FGFR3_uc010icb.1_Missense_Mutation_p.S91C|FGFR3_uc003gdt.1_Missense_Mutation_p.S91C	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	249	Extracellular (Potential).		S -> C (in KERSEB, bladder cancer, cervical cancer and TD1).		bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S249C(1368)|p.R248_S249insC(2)|p.S249T(1)|p.R248_S249del(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	ACAGAGCGCTCCCCGCACCGG	0.562		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				0	0	0	0.001368	0	11	19									
EVC	2121	broad.mit.edu	37	4	5754566	5754566	+	Missense_Mutation	SNP	G	G	A	rs145645536		TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr4:5754566G>A	uc003gil.1	+	9	1286	c.1102G>A	c.(1102-1104)GCC>ACC	p.A368T	EVC_uc003gim.1_RNA|CRMP1_uc003gin.1_Intron	NM_153717	NP_714928	P57679	EVC_HUMAN	Ellis van Creveld syndrome protein	368					muscle organ development	integral to membrane				ovary(1)|skin(1)	2		Myeloproliferative disorder(84;0.117)				TTTGCAGGACGCCCTGGAGAG	0.557		NaN											0	0	0	0.006999	0	39	64									
ADAMTS3	9508	broad.mit.edu	37	4	73185578	73185578	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr4:73185578T>C	uc003hgk.1	-	8	1242	c.1205A>G	c.(1204-1206)CAT>CGT	p.H402R		NM_014243	NP_055058	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1	402	Peptidase M12B.	Zinc; catalytic (By similarity).			collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)	2			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			GACTTACACATGGCCCGTTTC	0.448		NaN											0	0	0	0.006122	0	18	26									
AFF1	4299	broad.mit.edu	37	4	88053553	88053553	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr4:88053553A>G	uc003hqj.3	+	18	3690	c.3283A>G	c.(3283-3285)ATT>GTT	p.I1095V	AFF1_uc011ccz.1_Missense_Mutation_p.I1102V|AFF1_uc003hqk.3_Missense_Mutation_p.I1095V|AFF1_uc011cda.1_Missense_Mutation_p.I733V	NM_005935	NP_005926	P51825	AFF1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1095						nucleus	sequence-specific DNA binding transcription factor activity			breast(1)	1		Acute lymphoblastic leukemia(40;0.0935)|all_hematologic(202;0.111)|Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000233)		TTCTCCATGCATTGCAAGGTA	0.343		NaN											0	0	0	0.006122	0	17	25									
DDIT4L	115265	broad.mit.edu	37	4	101109268	101109268	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr4:101109268C>T	uc003hvq.2	-	3	351	c.148G>A	c.(148-150)GAG>AAG	p.E50K		NM_145244	NP_660287	Q96D03	DDT4L_HUMAN	DNA-damage-inducible transcript 4-like	50					negative regulation of signal transduction	cytoplasm				ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;5.75e-09)		GTTGATTCCTCAAATATTACC	0.368		NaN											0	0	0	0.009718	0	45	72									
PCDH10	57575	broad.mit.edu	37	4	134072260	134072260	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr4:134072260C>G	uc003iha.2	+	1	1791	c.965C>G	c.(964-966)CCA>CGA	p.P322R	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Missense_Mutation_p.P322R	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	322	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		GAAGAGAGCCCAGTGTACCAA	0.612		NaN											0	0	0	0.002852	0	41	78									
TLR2	7097	broad.mit.edu	37	4	154625251	154625251	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr4:154625251C>G	uc003inq.2	+	3	1411	c.1192C>G	c.(1192-1194)CAT>GAT	p.H398D	TLR2_uc003inr.2_Missense_Mutation_p.H398D|TLR2_uc003ins.2_Missense_Mutation_p.H398D	NM_003264	NP_003255	O60603	TLR2_HUMAN	toll-like receptor 2 precursor	398	LRR 9.|Extracellular (Potential).				cellular response to diacyl bacterial lipopeptide|cellular response to lipoteichoic acid|cellular response to triacyl bacterial lipopeptide|detection of diacyl bacterial lipopeptide|detection of triacyl bacterial lipopeptide|I-kappaB phosphorylation|induction of apoptosis|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of interferon-beta production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|positive regulation of Wnt receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	cytoplasm|integral to plasma membrane|Toll-like receptor 1-Toll-like receptor 2 protein complex	Gram-positive bacterial cell surface binding|lipopolysaccharide receptor activity|peptidoglycan binding|protein heterodimerization activity|transmembrane receptor activity|triacyl lipopeptide binding			ovary(1)|lung(1)|breast(1)	3	all_hematologic(180;0.093)	Renal(120;0.117)				AAGGCAAAATCATTTGGCATC	0.363		NaN											0	0	0	0.007413	0	19	47									
MARCH6	10299	broad.mit.edu	37	5	10402684	10402684	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr5:10402684C>G	uc003jet.1	+	14	1345	c.1162C>G	c.(1162-1164)CTC>GTC	p.L388V	MARCH6_uc011cmu.1_Missense_Mutation_p.L340V|MARCH6_uc003jeu.1_Missense_Mutation_p.L86V|MARCH6_uc011cmv.1_Missense_Mutation_p.L283V	NM_005885	NP_005876	O60337	MARH6_HUMAN	membrane-associated ring finger (C3HC4) 6	388	Helical; (Potential).				protein K48-linked ubiquitination	integral to endoplasmic reticulum membrane	ubiquitin conjugating enzyme binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|breast(1)	2						AGTATTCCCTCTCATTTGTGG	0.358		NaN											0	0	0	0.00361	0	86	183									
FAM151B	167555	broad.mit.edu	37	5	79797732	79797732	+	Silent	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr5:79797732G>C	uc003kgv.1	+	2	290	c.147G>C	c.(145-147)CTG>CTC	p.L49L	FAM151B_uc010jal.1_RNA	NM_205548	NP_991111	Q6UXP7	F151B_HUMAN	hypothetical protein LOC167555	49											0		Lung NSC(167;0.0427)|all_lung(232;0.0464)|Ovarian(174;0.113)		OV - Ovarian serous cystadenocarcinoma(54;8.21e-47)|Epithelial(54;8.3e-42)|all cancers(79;1.97e-36)		ATGAGGCACTGAAAAGTAAGT	0.368		NaN											0	0	0	0.007835	0	39	33									
EFNA5	1946	broad.mit.edu	37	5	106722987	106722987	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr5:106722987C>A	uc003kol.2	-	4	796	c.514G>T	c.(514-516)GAT>TAT	p.D172Y		NM_001962	NP_001953	P52803	EFNA5_HUMAN	ephrin-A5 precursor	172					cell-cell signaling	anchored to plasma membrane|caveola|extracellular space	ephrin receptor binding				0		all_cancers(142;5.15e-06)|all_epithelial(76;4.39e-07)|Prostate(80;0.00726)|Lung NSC(167;0.0736)|Ovarian(225;0.0797)|all_lung(232;0.0854)|Colorectal(57;0.241)		Epithelial(69;1.25e-12)|OV - Ovarian serous cystadenocarcinoma(64;1.32e-11)|BRCA - Breast invasive adenocarcinoma(61;0.0376)|COAD - Colon adenocarcinoma(37;0.109)		AAAACACGATCATGAACACCT	0.318		NaN											1	0	0.00010058	0.001368	0.000101631	8	7									
MAN2A1	4124	broad.mit.edu	37	5	109051929	109051929	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr5:109051929C>G	uc003kou.1	+	3	1462	c.499C>G	c.(499-501)CAA>GAA	p.Q167E		NM_002372	NP_002363	Q16706	MA2A1_HUMAN	mannosidase, alpha, class 2A, member 1	167	Lumenal (Potential).				mannose metabolic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane	alpha-mannosidase activity|carbohydrate binding|mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		all_cancers(142;8.66e-07)|all_epithelial(76;7.73e-09)|Prostate(80;0.000303)|Lung NSC(167;0.0186)|all_lung(232;0.0241)|Ovarian(225;0.0444)|Colorectal(57;0.0959)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;2.17e-10)|Epithelial(69;1.37e-09)|COAD - Colon adenocarcinoma(37;0.141)		TGAACCCCTTCAAGTCTTTGT	0.378		NaN											0	0	0	0.00278	0	24	26									
LARS	51520	broad.mit.edu	37	5	145557190	145557190	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr5:145557190C>G	uc003lnx.1	-	2	283	c.45G>C	c.(43-45)AAG>AAC	p.K15N	LARS_uc011dbq.1_Missense_Mutation_p.K15N|LARS_uc011dbr.1_Intron|LARS_uc011dbs.1_Missense_Mutation_p.K15N	NM_020117	NP_064502	Q9P2J5	SYLC_HUMAN	leucyl-tRNA synthetase	15					leucyl-tRNA aminoacylation	cytosol	ATP binding|leucine-tRNA ligase activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		L-Leucine(DB00149)	CTTTCTCAATCTTCTTCAAAA	0.363		NaN											0	0	0	0.010504	0	20	16									
ZNF454	285676	broad.mit.edu	37	5	178392337	178392337	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr5:178392337G>T	uc003mjo.1	+	5	1203	c.932G>T	c.(931-933)TGC>TTC	p.C311F	ZNF454_uc010jkz.1_Missense_Mutation_p.C311F	NM_182594	NP_872400	Q8N9F8	ZN454_HUMAN	zinc finger protein 454	311	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(89;0.000904)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.225)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.234)		GCCTTTGTGTGCAGGGCACAC	0.378		NaN											1	0	7.33628e-21	0.002299	7.79312e-21	21	22									
HIST1H2AK	8330	broad.mit.edu	37	6	27805964	27805964	+	Silent	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr6:27805964G>A	uc003njs.2	-	1	154	c.154C>T	c.(154-156)CTG>TTG	p.L52L	HIST1H2BN_uc003njt.1_5'Flank|HIST1H2BN_uc003nju.1_5'Flank|HIST1H2BN_uc003njv.2_5'Flank	NM_003510	NP_003501	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ak	52					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding			upper_aerodigestive_tract(1)	1						ACCGCCGCCAGGTACACCGGC	0.652		NaN											0	0	0	0.009096	0	4	63									
CFB	629	broad.mit.edu	37	6	31895930	31895930	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr6:31895930C>T	uc011dor.1	+	2	509	c.245C>T	c.(244-246)GCG>GTG	p.A82V	C2_uc003nyc.2_Intron|C2_uc011doo.1_Intron|C2_uc011dop.1_Intron|C2_uc003nye.3_Missense_Mutation_p.A82V|C2_uc003nyf.2_Missense_Mutation_p.A82V|C2_uc010jtk.2_Intron|C2_uc011doq.1_Missense_Mutation_p.R44W|C2_uc003nyg.2_Intron	NM_001710	NP_001701	P00751	CFAB_HUMAN	complement factor B preproprotein	156	Sushi 2.				complement activation, alternative pathway|proteolysis	extracellular region|plasma membrane	complement binding|serine-type endopeptidase activity			skin(1)	1						CTGTCTAAGGCGGTCTGCAAA	0.473		NaN											0	0	0	0.004672	0	3	13									
UHRF1BP1	54887	broad.mit.edu	37	6	34824635	34824635	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr6:34824635C>T	uc003oju.3	+	11	1594	c.1360C>T	c.(1360-1362)CAG>TAG	p.Q454*	UHRF1BP1_uc010jvm.1_RNA|UHRF1BP1_uc010jvn.2_RNA|UHRF1BP1_uc010jvo.2_5'Flank	NM_017754	NP_060224	Q6BDS2	URFB1_HUMAN	ICBP90 binding protein 1	454										ovary(3)	3						GCCTGCCTTTCAGCCTCCAGC	0.502		NaN											0	0	0	0.00278	0	22	47									
DAAM2	23500	broad.mit.edu	37	6	39828707	39828707	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr6:39828707G>A	uc003oow.2	+	3	328	c.172G>A	c.(172-174)GAA>AAA	p.E58K	DAAM2_uc010jxc.2_Missense_Mutation_p.E58K|DAAM2_uc003oox.2_Missense_Mutation_p.E58K|DAAM2_uc003oov.3_Missense_Mutation_p.E58K|DAAM2_uc003ooy.3_Missense_Mutation_p.E58K	NM_015345	NP_056160	Q86T65	DAAM2_HUMAN	dishevelled associated activator of	58	GBD/FH3.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)|skin(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					TTTGCAGGATGAATTGGATCT	0.448		NaN											0	0	0	0.004482	0	9	15									
DST	667	broad.mit.edu	37	6	56492874	56492874	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr6:56492874C>T	uc003pdf.2	-	32	4490	c.4462G>A	c.(4462-4464)GAA>AAA	p.E1488K	DST_uc003pcz.3_Missense_Mutation_p.E1310K|DST_uc011dxj.1_Missense_Mutation_p.E1339K|DST_uc011dxk.1_Missense_Mutation_p.E1350K|DST_uc003pcy.3_Missense_Mutation_p.E984K|DST_uc003pdb.2_Missense_Mutation_p.E984K|DST_uc003pdc.3_Missense_Mutation_p.E984K|DST_uc003pdd.3_Missense_Mutation_p.E984K	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	1310					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TGAGTAGTTTCAACCTGCTGG	0.388		NaN											0	0	0	0.00278	0	21	48									
KCNQ5	56479	broad.mit.edu	37	6	73751677	73751677	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr6:73751677G>A	uc003pgk.2	+	3	855	c.508G>A	c.(508-510)GTC>ATC	p.V170I	KCNQ5_uc003pgj.3_Missense_Mutation_p.V170I|KCNQ5_uc011dyh.1_Missense_Mutation_p.V170I|KCNQ5_uc011dyi.1_Missense_Mutation_p.V170I|KCNQ5_uc010kat.2_Missense_Mutation_p.V170I|KCNQ5_uc011dyj.1_Missense_Mutation_p.V170I|KCNQ5_uc011dyk.1_Intron	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	170	Helical; Name=Segment S2; (Potential).				protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		GATGATTGTCGTCTTTGGTTT	0.423		NaN											0	0	0	0.00361	0	71	141									
MDN1	23195	broad.mit.edu	37	6	90402857	90402857	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr6:90402857G>A	uc003pnn.1	-	63	10008	c.9892C>T	c.(9892-9894)CAA>TAA	p.Q3298*		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	3298					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TCCATCCTTTGGCGAAGCAGC	0.473		NaN											0	0	0	0.00308	0	8	26									
C6orf167	253714	broad.mit.edu	37	6	97626386	97626386	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr6:97626386G>A	uc003ppb.2	-	18	2878	c.2612C>T	c.(2611-2613)TCA>TTA	p.S871L	C6orf167_uc011eaf.1_Missense_Mutation_p.S831L	NM_198468	NP_940870	Q6ZRQ5	MMS22_HUMAN	hypothetical protein LOC253714	871					double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding				0		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.148)|Colorectal(196;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.0457)		TTGGGCCTTTGAGAAAATACT	0.299		NaN											0	0	0	0.003163	0	14	46									
COQ3	51805	broad.mit.edu	37	6	99823896	99823896	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr6:99823896C>G	uc003ppk.2	-	5	676	c.649G>C	c.(649-651)GAT>CAT	p.D217H		NM_017421	NP_059117	Q9NZJ6	COQ3_HUMAN	hexaprenyldihydroxybenzoate methyltransferase	217					glycerol metabolic process|ubiquinone biosynthetic process	mitochondrial matrix	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity|3-demethylubiquinone-9 3-O-methyltransferase activity|hexaprenyldihydroxybenzoate methyltransferase activity	p.D217H(1)		upper_aerodigestive_tract(1)	1		all_cancers(76;1.24e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00716)|Colorectal(196;0.0691)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0625)		ACAACAGCATCAAATGTTTCT	0.388		NaN											0	0	0	0.00623	0	40	116									
SIM1	6492	broad.mit.edu	37	6	100896129	100896129	+	Splice_Site	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr6:100896129C>G	uc003pqj.3	-	7	951	c.744_splice	c.e7-1	p.R248_splice	SIM1_uc010kcu.2_Splice_Site_p.R248_splice	NM_005068	NP_005059	P81133	SIM1_HUMAN	single-minded homolog 1						cell differentiation|nervous system development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity			ovary(4)	4		all_cancers(76;9.88e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0248)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0774)		CTCCGCCACCCTGAGGAGAGC	0.637		NaN											0	0	0	0.009096	0	4	25									
LAMA4	3910	broad.mit.edu	37	6	112476059	112476059	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr6:112476059C>G	uc003pvu.2	-	16	2359	c.2050G>C	c.(2050-2052)GAG>CAG	p.E684Q	LAMA4_uc003pvv.2_Missense_Mutation_p.E677Q|LAMA4_uc003pvt.2_Missense_Mutation_p.E677Q	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	684	Domain II and I.|Potential.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		TTACTAGACTCTGCCTTTGCT	0.393		NaN											0	0	0	0.005443	0	25	58									
VNN2	8875	broad.mit.edu	37	6	133073771	133073771	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr6:133073771G>T	uc003qdt.2	-	4	666	c.655C>A	c.(655-657)CCT>ACT	p.P219T	VNN2_uc003qds.2_Intron|VNN2_uc010kgb.2_Intron|VNN2_uc003qdv.2_Missense_Mutation_p.P166T	NM_004665	NP_004656	O95498	VNN2_HUMAN	vanin 2 isoform 1 precursor	219	CN hydrolase.				cellular component movement|pantothenate metabolic process	anchored to membrane|plasma membrane	pantetheine hydrolase activity				0				OV - Ovarian serous cystadenocarcinoma(155;0.00237)|GBM - Glioblastoma multiforme(226;0.0267)		GTAACACCAGGATCATAGAAG	0.438		NaN											1	0	9.84934e-19	0.002522	1.04245e-18	45	109									
THBS2	7058	broad.mit.edu	37	6	169623541	169623541	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr6:169623541C>T	uc003qwt.2	-	19	3051	c.2803G>A	c.(2803-2805)GAT>AAT	p.D935N		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	935	TSP type-3 8.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		TTGTCAAAATCATCTTTACAA	0.393		NaN											0	0	0	0.007291	0	28	54									
SUN1	23353	broad.mit.edu	37	7	883137	883137	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr7:883137C>G	uc011jvp.1	+	6	717	c.638C>G	c.(637-639)TCT>TGT	p.S213C	SUN1_uc010ksa.1_Missense_Mutation_p.S234C|SUN1_uc003sje.1_Missense_Mutation_p.S213C|SUN1_uc003sjf.2_Missense_Mutation_p.S163C|SUN1_uc011jvq.1_Intron|SUN1_uc003sjg.2_Missense_Mutation_p.S24C	NM_001130965	NP_001124437	O94901	SUN1_HUMAN	unc-84 homolog A isoform a	213	SYNE2-binding.|Nuclear.				cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding				0						AGAGTTTATTCTAGGGACAGG	0.502		NaN											0	0	0	0.00361	0	79	186									
KIAA0415	9907	broad.mit.edu	37	7	4830402	4830402	+	Silent	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr7:4830402C>T	uc003sne.2	+	16	2120	c.2037C>T	c.(2035-2037)TTC>TTT	p.F679F	KIAA0415_uc010ksp.2_RNA|KIAA0415_uc003snf.2_Silent_p.F156F	NM_014855	NP_055670	O43299	K0415_HUMAN	hypothetical protein LOC9907	679					cell death|double-strand break repair via homologous recombination	cytoplasm|nucleus	protein binding			central_nervous_system(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.091)|OV - Ovarian serous cystadenocarcinoma(56;8.35e-15)		CTCTGCTATTCGAGGTCACCC	0.647		NaN											0	0	0	0.00308	0	8	11									
C7orf28A	51622	broad.mit.edu	37	7	5942310	5942310	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr7:5942310C>G	uc003spf.2	+	6	547	c.457C>G	c.(457-459)CTG>GTG	p.L153V		NM_015622	NP_056437	P86791	CCZ1_HUMAN	hypothetical protein LOC51622	153				LKAMEDGGVK -> PESHGRRRVQ (in Ref. 1; AAD34038).		lysosomal membrane					0		Ovarian(82;0.0694)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0974)|OV - Ovarian serous cystadenocarcinoma(56;7.91e-15)		TGGTACATTTCTGAAAGCCAT	0.323		NaN											0	0	0	0.005443	0	19	33									
ABCA13	154664	broad.mit.edu	37	7	48312697	48312697	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr7:48312697A>G	uc003toq.2	+	17	3459	c.3434A>G	c.(3433-3435)CAC>CGC	p.H1145R	ABCA13_uc010kyr.2_Missense_Mutation_p.H648R	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	1145					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						ATGTCCATTCACTGTACCGTT	0.353		NaN											0	0	0	0.006122	0	15	43									
ASL	435	broad.mit.edu	37	7	65548157	65548157	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr7:65548157G>C	uc003tuo.2	+	6	553	c.442G>C	c.(442-444)GAG>CAG	p.E148Q	ASL_uc011kdu.1_Missense_Mutation_p.E148Q|ASL_uc010kzx.1_3'UTR|ASL_uc011kdv.1_Missense_Mutation_p.E148Q|ASL_uc003tup.2_Missense_Mutation_p.E148Q|ASL_uc003tur.2_Missense_Mutation_p.E148Q|ASL_uc003tuq.2_Missense_Mutation_p.E148Q	NM_000048	NP_000039	P04424	ARLY_HUMAN	argininosuccinate lyase isoform 1	148					arginine biosynthetic process via ornithine|arginine catabolic process|urea cycle	cytosol	argininosuccinate lyase activity			breast(2)	2					L-Arginine(DB00125)	GGATCGGGCAGAGGCGTGAGT	0.637		NaN											0	0	0	0.004007	0	16	22									
CYP3A4	1576	broad.mit.edu	37	7	99367796	99367796	+	Silent	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr7:99367796C>T	uc003urv.1	-	5	485	c.381G>A	c.(379-381)AAG>AAA	p.K127K	CYP3A4_uc003urw.1_Silent_p.K127K|CYP3A4_uc011kiz.1_Intron|CYP3A4_uc011kja.1_Silent_p.K78K|CYP3A4_uc011kjb.1_Intron	NM_017460	NP_059488	P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A,	127					alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			central_nervous_system(3)|ovary(1)	4	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	ATCGTAATCTCTTCCATTCTT	0.378		NaN											0	0	0	0.003271	0	34	58									
UBN2	254048	broad.mit.edu	37	7	138968238	138968238	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr7:138968238C>G	uc011kqr.1	+	15	2587	c.2587C>G	c.(2587-2589)CAG>GAG	p.Q863E		NM_173569	NP_775840	Q6ZU65	UBN2_HUMAN	ubinuclein 2	863										ovary(1)|skin(1)	2						TTCTTCCATTCAGAACCCTAA	0.463		NaN											0	0	0	0.006999	0	42	66									
ZNF777	27153	broad.mit.edu	37	7	149152725	149152725	+	Missense_Mutation	SNP	T	T	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr7:149152725T>G	uc003wfv.2	-	2	552	c.389A>C	c.(388-390)CAC>CCC	p.H130P		NM_015694	NP_056509	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	130					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			TTCAGGGGAGTGAACGGGGGC	0.612		NaN											0	0	0	0.00361	0	98	192									
NOS3	4846	broad.mit.edu	37	7	150699002	150699002	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr7:150699002G>C	uc003wif.2	+	13	1892	c.1596G>C	c.(1594-1596)CAG>CAC	p.Q532H	NOS3_uc011kuy.1_Missense_Mutation_p.Q326H|NOS3_uc011kuz.1_Missense_Mutation_p.Q532H|NOS3_uc011kva.1_Missense_Mutation_p.Q532H|NOS3_uc011kvb.1_Missense_Mutation_p.Q532H	NM_000603	NP_000594	P29474	NOS3_HUMAN	nitric oxide synthase 3 isoform 1	532	Flavodoxin-like.				anti-apoptosis|arginine catabolic process|blood vessel remodeling|endothelial cell migration|mitochondrion organization|negative regulation of muscle hyperplasia|negative regulation of platelet activation|nitric oxide biosynthetic process|platelet activation|positive regulation of angiogenesis|positive regulation of guanylate cyclase activity|positive regulation of vasodilation|regulation of blood vessel size|regulation of nitric-oxide synthase activity|regulation of systemic arterial blood pressure by endothelin|response to fluid shear stress|response to heat|smooth muscle hyperplasia	caveola|cytoskeleton|cytosol|Golgi membrane	actin monomer binding|arginine binding|cadmium ion binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|tetrahydrobiopterin binding			central_nervous_system(5)|large_intestine(2)|skin(1)	8	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	L-Arginine(DB00125)|L-Citrulline(DB00155)|Rosuvastatin(DB01098)|Tetrahydrobiopterin(DB00360)	GCCGGGCCCAGAGCTACGCAC	0.647		NaN											0	0	0	0.006122	0	19	39									
LGI3	203190	broad.mit.edu	37	8	22005745	22005745	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr8:22005745C>A	uc003xav.2	-	8	1864	c.1575G>T	c.(1573-1575)CAG>CAT	p.Q525H	LGI3_uc010ltu.2_Missense_Mutation_p.Q501H	NM_139278	NP_644807	Q8N145	LGI3_HUMAN	leucine-rich repeat LGI family, member 3	525	EAR 7.				exocytosis	cell junction|extracellular region|synaptic vesicle|synaptosome				ovary(1)	1				Colorectal(74;0.00189)|COAD - Colon adenocarcinoma(73;0.0612)|READ - Rectum adenocarcinoma(644;0.0999)		CCAGGAGTAGCTGGGCGTCCC	0.607		NaN											1	0	7.11191e-15	0.002836	7.47266e-15	34	39									
GSR	2936	broad.mit.edu	37	8	30557646	30557646	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr8:30557646C>T	uc003xih.1	-	6	738	c.647G>A	c.(646-648)AGC>AAC	p.S216N		NM_000637	NP_000628	P00390	GSHR_HUMAN	glutathione reductase precursor	216					cell redox homeostasis|nucleobase, nucleoside and nucleotide interconversion	cytosol|mitochondrion	electron carrier activity|glutathione-disulfide reductase activity			ovary(2)|pancreas(2)|central_nervous_system(1)	5				KIRC - Kidney renal clear cell carcinoma(542;0.105)|Kidney(114;0.125)	Carmustine(DB00262)|Glutathione(DB00143)|NADH(DB00157)	TATTCCTAAGCTGGCACCTAT	0.428		NaN											0	0	0	0.00333	0	24	25									
ADAM32	203102	broad.mit.edu	37	8	39044508	39044508	+	Silent	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr8:39044508C>T	uc003xmt.3	+	11	1241	c.996C>T	c.(994-996)GAC>GAT	p.D332D	ADAM32_uc011lch.1_Intron|ADAM32_uc003xmu.3_Intron	NM_145004	NP_659441	Q8TC27	ADA32_HUMAN	a disintegrin and metalloprotease domain 32	332	Peptidase M12B.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(1)|lung(1)|kidney(1)	3		all_cancers(7;3e-05)|all_lung(54;0.00187)|Hepatocellular(245;0.00745)|Lung NSC(58;0.00771)|Breast(189;0.0503)	LUSC - Lung squamous cell carcinoma(45;6.2e-07)|Colorectal(1;0.00699)|READ - Rectum adenocarcinoma(1;0.146)			TATCATATGACGACCCAAAGA	0.348		NaN											0	0	0	0.00361	0	103	32									
RDH10	157506	broad.mit.edu	37	8	74235043	74235043	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr8:74235043G>C	uc003xzi.2	+	5	1160	c.900G>C	c.(898-900)AAG>AAC	p.K300N	RDH10_uc003xzj.2_Missense_Mutation_p.K135N|uc003xzk.1_Intron	NM_172037	NP_742034	Q8IZV5	RDH10_HUMAN	retinol dehydrogenase 10	300					retinal metabolic process|retinol metabolic process|visual perception	endoplasmic reticulum membrane|integral to membrane|microsome	binding|NADP-retinol dehydrogenase activity|retinol dehydrogenase activity				0	Breast(64;0.0954)		Epithelial(68;0.0105)|all cancers(69;0.0465)|BRCA - Breast invasive adenocarcinoma(89;0.0608)			CCTTCATGAAGAGGTAACTGG	0.512		NaN											0	0	0	0.002836	0	31	51									
ZFAND1	79752	broad.mit.edu	37	8	82626198	82626198	+	Silent	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr8:82626198C>T	uc003ycj.1	-	6	449	c.435G>A	c.(433-435)TTG>TTA	p.L145L	ZFAND1_uc010lzx.1_Silent_p.L145L|ZFAND1_uc003yck.1_Silent_p.L38L	NM_024699	NP_078975	Q8TCF1	ZFAN1_HUMAN	zinc finger, AN1-type domain 1	145							zinc ion binding			ovary(1)	1						TTAATTTCATCAATGCAACCT	0.313		NaN											0	0	0	0.007413	0	19	27									
RAD54B	25788	broad.mit.edu	37	8	95392433	95392433	+	Silent	SNP	G	G	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr8:95392433G>T	uc003ygk.2	-	12	2285	c.2187C>A	c.(2185-2187)CTC>CTA	p.L729L	RAD54B_uc010may.1_Silent_p.L536L	NM_012415	NP_036547	O95073	FSBP_HUMAN	RAD54 homolog B	Error:Variant_position_missing_in_O95073_after_alignment					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding			kidney(2)|lung(1)|skin(1)	4	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)			ATCCTCCAATGAGGTTAAGTC	0.318		NaN						Direct_reversal_of_damage|Homologous_recombination					1	0	1.49906e-05	0.00245	1.52536e-05	14	19									
RAD54B	25788	broad.mit.edu	37	8	95392461	95392461	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr8:95392461G>C	uc003ygk.2	-	12	2257	c.2159C>G	c.(2158-2160)TCA>TGA	p.S720*	RAD54B_uc010may.1_Nonsense_Mutation_p.S527*	NM_012415	NP_036547	O95073	FSBP_HUMAN	RAD54 homolog B	Error:Variant_position_missing_in_O95073_after_alignment					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding			kidney(2)|lung(1)|skin(1)	4	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)			ACCAGCTTTTGAACTTAACAA	0.368		NaN						Direct_reversal_of_damage|Homologous_recombination					0	0	0	0.008291	0	11	24									
UBR5	51366	broad.mit.edu	37	8	103357737	103357737	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr8:103357737G>A	uc003ykr.1	-	8	806	c.773C>T	c.(772-774)TCT>TTT	p.S258F	UBR5_uc003yks.1_Missense_Mutation_p.S258F	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin	258				S -> Y (in Ref. 2; AAF88143).	cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			TGGGTGGGCAGAATGAATGTC	0.413		NaN											0	0	0	0.006122	0	17	31									
CSMD3	114788	broad.mit.edu	37	8	113529420	113529420	+	Silent	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr8:113529420G>A	uc003ynu.2	-	28	4758	c.4599C>T	c.(4597-4599)GTC>GTT	p.V1533V	CSMD3_uc003yns.2_Silent_p.V805V|CSMD3_uc003ynt.2_Silent_p.V1493V|CSMD3_uc011lhx.1_Silent_p.V1429V	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1533	Extracellular (Potential).|Sushi 8.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CATTCATGGGGACCCCTGGGT	0.423		NaN								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.007413	0	17	30									
HAS2	3037	broad.mit.edu	37	8	122626714	122626714	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr8:122626714C>G	uc003yph.2	-	4	1832	c.1294G>C	c.(1294-1296)GTC>CTC	p.V432L		NM_005328	NP_005319	Q92819	HAS2_HUMAN	hyaluronan synthase 2	432	Helical; Name=5; (Potential).					integral to plasma membrane	hyaluronan synthase activity		HAS2/PLAG1(10)	soft_tissue(10)|ovary(5)	15	Lung NSC(37;3.12e-08)|Ovarian(258;0.0254)|Hepatocellular(40;0.0997)|all_neural(195;0.142)		STAD - Stomach adenocarcinoma(47;0.00503)			AAGACCATGACGATATTTCCT	0.428		NaN											0	0	0	0.004482	0	9	206									
DGAT1	8694	broad.mit.edu	37	8	145540687	145540687	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr8:145540687C>G	uc003zbv.3	-	15	1514	c.1246G>C	c.(1246-1248)GAG>CAG	p.E416Q	DGAT1_uc010mfv.2_Missense_Mutation_p.R250P	NM_012079	NP_036211	O75907	DGAT1_HUMAN	diacylglycerol O-acyltransferase 1	416	Lumenal (Potential).				triglyceride biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane	diacylglycerol O-acyltransferase activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.94e-40)|Epithelial(56;7.67e-40)|all cancers(56;7.88e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			GCACTGACCTCGTGGAAGAAG	0.647		NaN											0	0	0	0.006122	0	19	37									
TTC16	158248	broad.mit.edu	37	9	130482603	130482603	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr9:130482603G>T	uc004brq.1	+	6	653	c.586G>T	c.(586-588)GAG>TAG	p.E196*	PTRH1_uc011mah.1_Intron|TTC16_uc011mai.1_Nonsense_Mutation_p.E183*|TTC16_uc004brr.1_Nonsense_Mutation_p.E141*|TTC16_uc010mxn.1_5'UTR	NM_144965	NP_659402	Q8NEE8	TTC16_HUMAN	tetratricopeptide repeat domain 16	196							binding				0						CATCACCAACGAGCTGAAGCA	0.622		NaN											1	0	4.18559e-23	0.00361	4.46257e-23	50	37									
TSC1	7248	broad.mit.edu	37	9	135781236	135781236	+	Nonsense_Mutation	SNP	C	C	A	rs118203570		TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr9:135781236C>A	uc004cca.2	-	15	1963	c.1729G>T	c.(1729-1731)GAG>TAG	p.E577*	TSC1_uc004ccb.3_Nonsense_Mutation_p.E576*|TSC1_uc011mcq.1_Nonsense_Mutation_p.E526*|TSC1_uc011mcr.1_Intron	NM_000368	NP_000359	Q92574	TSC1_HUMAN	tuberous sclerosis 1 protein isoform 1	577			E -> D.		activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.?(1)		lung(4)|central_nervous_system(3)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|urinary_tract(1)|skin(1)|ovary(1)|bone(1)	14				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		ATACTGGTCTCCAAAGAAGTC	0.547		NaN	D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				1	0	4.26978e-12	0.00333	4.43812e-12	22	21									
GPSM1	26086	broad.mit.edu	37	9	139250815	139250815	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr9:139250815C>T	uc004chd.2	+	13	1854	c.1634C>T	c.(1633-1635)TCG>TTG	p.S545L	GPSM1_uc011mdu.1_Missense_Mutation_p.S36L|GPSM1_uc004che.2_Missense_Mutation_p.S36L	NM_001145638	NP_001139110	Q86YR5	GPSM1_HUMAN	G-protein signaling modulator 1 (AGS3-like, C.	545					cell differentiation|nervous system development|signal transduction	cytosol|endoplasmic reticulum membrane|Golgi membrane|plasma membrane	binding|GTPase activator activity				0		Myeloproliferative disorder(178;0.0821)		OV - Ovarian serous cystadenocarcinoma(145;2.39e-06)|Epithelial(140;3.24e-06)		ATGACGGCCTCGCCCCAGACC	0.721		NaN											0	0	0	0.004482	0	9	8									
CCDC120	90060	broad.mit.edu	37	X	48925325	48925325	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chrX:48925325G>C	uc010nik.2	+	10	2077	c.1570G>C	c.(1570-1572)GAA>CAA	p.E524Q	CCDC120_uc011mmq.1_Missense_Mutation_p.E512Q|CCDC120_uc004dmf.2_Missense_Mutation_p.E524Q|CCDC120_uc010nil.2_Missense_Mutation_p.E524Q|CCDC120_uc011mmr.1_Missense_Mutation_p.E524Q|CCDC120_uc011mms.1_Missense_Mutation_p.E512Q	NM_033626	NP_296375	Q96HB5	CC120_HUMAN	coiled-coil domain containing 120 isoform 3	524	Pro-rich.						protein binding			pancreas(1)	1						AGAGGCTGCCGAAGGCCCTGA	0.657		NaN											0	0	0	0.009096	0	4	0									
UBQLN2	29978	broad.mit.edu	37	X	56591564	56591564	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chrX:56591564C>G	uc004dus.2	+	1	1493	c.1258C>G	c.(1258-1260)CCT>GCT	p.P420A	UBQLN2_uc011moq.1_Missense_Mutation_p.P420A	NM_013444	NP_038472	Q9UHD9	UBQL2_HUMAN	ubiquilin 2	420						cytoplasm|nucleus|plasma membrane	binding			ovary(1)|skin(1)	2						TACTGCAAATCCTCAGCTGCA	0.542		NaN											0	0	0	0.000978	0	12	5									
ZC3H12B	340554	broad.mit.edu	37	X	64722819	64722819	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chrX:64722819G>C	uc010nko.2	+	5	2217	c.2208G>C	c.(2206-2208)TTG>TTC	p.L736F		NM_001010888	NP_001010888	Q5HYM0	ZC12B_HUMAN	zinc finger CCCH-type containing 12B	736							endonuclease activity|nucleic acid binding|zinc ion binding			lung(1)|kidney(1)|pancreas(1)	3						CCTATCCCTTGAGTAACAGCC	0.557		NaN											0	0	0	0.003163	0	16	11									
TMEM31	203562	broad.mit.edu	37	X	102968912	102968912	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chrX:102968912C>G	uc004elh.2	+	3	684	c.493C>G	c.(493-495)CTG>GTG	p.L165V	GLRA4_uc011mse.1_Intron	NM_182541	NP_872347	Q5JXX7	TMM31_HUMAN	transmembrane protein 31	165	Helical; (Potential).					integral to membrane					0						tgtcttcattctgatcttctt	0.159		NaN											0	0	0	0.001984	0	7	2									
STAG2	10735	broad.mit.edu	37	X	123176495	123176495	+	Silent	SNP	G	G	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chrX:123176495G>A	uc004etz.3	+	6	801	c.462G>A	c.(460-462)GAG>GAA	p.E154E	STAG2_uc004eua.2_Silent_p.E154E|STAG2_uc004eub.2_Silent_p.E154E|STAG2_uc004euc.2_Silent_p.E154E|STAG2_uc004eud.2_Silent_p.E154E|STAG2_uc004eue.2_Silent_p.E154E	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	154					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						AATTCGATGAGGTAACTTACT	0.279		NaN											0	0	0	0.00245	0	15	5									
ENOX2	10495	broad.mit.edu	37	X	129771250	129771250	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chrX:129771250C>G	uc004evw.2	-	12	1769	c.1351G>C	c.(1351-1353)GAA>CAA	p.E451Q	ENOX2_uc004evx.2_Missense_Mutation_p.E422Q|ENOX2_uc004evy.2_Missense_Mutation_p.E422Q|ENOX2_uc004evv.2_Missense_Mutation_p.E276Q	NM_182314	NP_872114	Q16206	ENOX2_HUMAN	ecto-NOX disulfide-thiol exchanger 2 isoform b	451	Potential.				cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			ovary(1)	1						AGCTGCTGTTCTTTGTTAGGG	0.473		NaN											0	0	0	0.00361	0	83	44									
ENOX2	10495	broad.mit.edu	37	X	129771262	129771262	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chrX:129771262C>A	uc004evw.2	-	12	1757	c.1339G>T	c.(1339-1341)GAC>TAC	p.D447Y	ENOX2_uc004evx.2_Missense_Mutation_p.D418Y|ENOX2_uc004evy.2_Missense_Mutation_p.D418Y|ENOX2_uc004evv.2_Missense_Mutation_p.D272Y	NM_182314	NP_872114	Q16206	ENOX2_HUMAN	ecto-NOX disulfide-thiol exchanger 2 isoform b	447	Potential.				cell growth|electron transport chain|regulation of growth|transport|ultradian rhythm	cytosol|external side of plasma membrane|extracellular space	nucleic acid binding|nucleotide binding|protein disulfide oxidoreductase activity			ovary(1)	1						TTGTTAGGGTCATCTTCTCTG	0.473		NaN											1	0	5.00475e-40	0.00361	5.39545e-40	84	41									
SPANXC	64663	broad.mit.edu	37	X	140336533	140336533	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chrX:140336533C>T	uc004fbk.2	-	1	114	c.58G>A	c.(58-60)GAG>AAG	p.E20K	SPANXC_uc004fbl.2_Intron	NM_022661	NP_073152	Q9NY87	SPNXC_HUMAN	sperm protein associated with the nucleus, X	20						cytoplasm|nucleus					0	Acute lymphoblastic leukemia(192;7.65e-05)					TCATTCACCTCGTTGGATTCA	0.303		NaN											0	0	0	0.00361	0	52	30									
IL22RA1	58985	broad.mit.edu	37	1	24463780	24463780	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr1:24463780delC	uc001biq.1	-	3	235	c.196delG	c.(196-198)GTGfs	p.V66fs	IL22RA1_uc010oeg.1_5'UTR|IL22RA1_uc009vrb.1_5'UTR|IL22RA1_uc010oeh.1_Frame_Shift_Del_p.V66fs	NM_021258	NP_067081	Q8N6P7	I22R1_HUMAN	interleukin 22 receptor, alpha 1 precursor	66	Extracellular (Potential).|Fibronectin type-III 1.					integral to membrane	interferon receptor activity			skin(1)	1		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000992)|all_lung(284;0.00138)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-24)|Colorectal(126;6.43e-08)|COAD - Colon adenocarcinoma(152;3.51e-06)|GBM - Glioblastoma multiforme(114;5.06e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00911)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.148)		TTCTTTGCCACCCAGTCCCTC	0.587		NaN											NaN	NaN	NaN	NaN	NaN	22	75	---	---							
ROBO3	64221	broad.mit.edu	37	11	124750448	124750453	+	In_Frame_Del	DEL	CGGAGT	CGGAGT	-	rs71859853		TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr11:124750448_124750453delCGGAGT	uc001qbc.2	+	27	4285_4290	c.4093_4098delCGGAGT	c.(4093-4098)CGGAGTdel	p.RS1367del	ROBO3_uc001qbd.2_In_Frame_Del_p.RS292del|ROBO3_uc010sar.1_In_Frame_Del_p.RS416del|ROBO3_uc001qbe.2_In_Frame_Del_p.RS292del|ROBO3_uc001qbf.1_In_Frame_Del_p.RS251del	NM_022370	NP_071765	Q96MS0	ROBO3_HUMAN	roundabout, axon guidance receptor, homolog 3	1367_1368	Cytoplasmic (Potential).				axon midline choice point recognition	integral to membrane	receptor activity			breast(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|Breast(109;0.0481)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0296)		TGgccggagccggagtcggagtcaga	0.519		NaN											NaN	NaN	NaN	NaN	NaN	3	5	---	---							
CAB39L	81617	broad.mit.edu	37	13	49957036	49957037	+	Frame_Shift_Ins	INS	-	-	T			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr13:49957036_49957037insT	uc001vcw.2	-	2	508_509	c.10_11insA	c.(10-12)ATGfs	p.M4fs	CAB39L_uc001vcx.2_Frame_Shift_Ins_p.M4fs|CAB39L_uc010adf.2_Frame_Shift_Ins_p.M1fs	NM_030925	NP_112187	Q9H9S4	CB39L_HUMAN	calcium binding protein 39-like	4					cell cycle arrest|insulin receptor signaling pathway|regulation of fatty acid oxidation	cytosol	protein binding				0		Lung NSC(96;2.11e-05)|Breast(56;0.00017)|Prostate(109;0.00314)|Hepatocellular(98;0.0207)|Myeloproliferative disorder(33;0.163)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;3.66e-09)|COAD - Colon adenocarcinoma(199;0.226)		AAACAAAGGCATTTTTTTCATG	0.287		NaN											NaN	NaN	NaN	NaN	NaN	16	63	---	---							
FOXA1	3169	broad.mit.edu	37	14	38061263	38061263	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08			G	-	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr14:38061263delG	uc001wuf.2	-	2	1038	c.726delC	c.(724-726)TCCfs	p.S242fs	FOXA1_uc010tpz.1_Frame_Shift_Del_p.S209fs	NM_004496	NP_004487	P55317	FOXA1_HUMAN	forkhead box A1	242	Fork-head.				chromatin remodeling|embryo development|epithelial cell maturation involved in prostate gland development|epithelial tube branching involved in lung morphogenesis|epithelial-mesenchymal signaling involved in prostate gland development|glucose homeostasis|lung epithelial cell differentiation|negative regulation of survival gene product expression|neuron fate specification|pattern specification process|positive regulation of estrogen receptor signaling pathway|positive regulation of mitotic cell cycle|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|prostate gland epithelium morphogenesis|prostate gland stromal morphogenesis|response to estradiol stimulus|secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development	transcription factor complex	DNA bending activity|double-stranded DNA binding|protein domain specific binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|transcription regulatory region DNA binding				0	Breast(36;0.0954)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;5.41e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.0454)|LUSC - Lung squamous cell carcinoma(13;0.0917)|all cancers(34;0.0925)|BRCA - Breast invasive adenocarcinoma(188;0.239)	GBM - Glioblastoma multiforme(112;0.0222)		GCGTCCAGTAGGAGCCCTTGC	0.587		NaN											NaN	NaN	NaN	NaN	NaN	46	39	---	---							
SPG21	51324	broad.mit.edu	37	15	65275846	65275846	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr15:65275846delT	uc002aod.2	-	2	155	c.62delA	c.(61-63)AAGfs	p.K21fs	SPG21_uc002aoe.2_Frame_Shift_Del_p.K21fs|SPG21_uc010bhb.2_Frame_Shift_Del_p.K21fs|SPG21_uc010bhc.2_5'UTR	NM_001127889	NP_001121361	Q9NZD8	SPG21_HUMAN	spastic paraplegia 21 isoform a	21					cell death	cytosol|endosome membrane|trans-Golgi network transport vesicle	CD4 receptor binding				0						CATACATACCTTTTTAAGGGG	0.333		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---							
TNRC6A	27327	broad.mit.edu	37	16	24807240	24807240	+	Frame_Shift_Del	DEL	A	A	-			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr16:24807240delA	uc002dmm.2	+	9	3655	c.3541delA	c.(3541-3543)AAAfs	p.K1181fs	TNRC6A_uc010bxs.2_Frame_Shift_Del_p.K928fs|TNRC6A_uc010vcc.1_Frame_Shift_Del_p.K928fs|TNRC6A_uc002dmn.2_Frame_Shift_Del_p.K928fs|TNRC6A_uc002dmo.2_Frame_Shift_Del_p.K869fs	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1181	Sufficient for interaction with EIF2C1 and EIF2C4.				negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		TCTGAGTGGCAAAAAAAGGAG	0.224		NaN											NaN	NaN	NaN	NaN	NaN	7	164	---	---							
MYOM1	8736	broad.mit.edu	37	18	3164366	3164366	+	Frame_Shift_Del	DEL	G	G	-			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr18:3164366delG	uc002klp.2	-	10	1745	c.1411delC	c.(1411-1413)CATfs	p.H471fs	MYOM1_uc002klq.2_Frame_Shift_Del_p.H471fs	NM_003803	NP_003794	P52179	MYOM1_HUMAN	myomesin 1 isoform a	471	Ig-like C2-type 2.					striated muscle myosin thick filament	structural constituent of muscle			ovary(3)|central_nervous_system(1)|pancreas(1)	5						TTGTTGAGATGGGAAAATGTC	0.393		NaN											NaN	NaN	NaN	NaN	NaN	9	15	---	---							
NGEF	25791	broad.mit.edu	37	2	233744322	233744324	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr2:233744322_233744324delCTC	uc002vts.2	-	15	2256_2258	c.2008_2010delGAG	c.(2008-2010)GAGdel	p.E670del	NGEF_uc010zmm.1_In_Frame_Del_p.E393del|NGEF_uc010fyg.1_In_Frame_Del_p.E578del	NM_019850	NP_062824	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	670	SH3.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)|skin(1)	7		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		GATTCAAGATCTCCTCAGTCATG	0.581		NaN											NaN	NaN	NaN	NaN	NaN	44	106	---	---							
CDKN1A	1026	broad.mit.edu	37	6	36652009	36652010	+	Frame_Shift_Ins	INS	-	-	GG			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08			-	GG	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr6:36652009_36652010insGG	uc003omm.3	+	2	253_254	c.131_132insGG	c.(130-132)GAGfs	p.E44fs	CDKN1A_uc011dtq.1_Frame_Shift_Ins_p.E78fs|CDKN1A_uc003oml.2_Frame_Shift_Ins_p.E44fs|CDKN1A_uc003omn.2_Frame_Shift_Ins_p.E44fs	NM_000389	NP_000380	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A	44					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			ovary(1)|breast(1)	2						TGCATCCAGGAGGCCCGTGAGC	0.658		NaN							Multiple_Endocrine_Neoplasia_type_1				NaN	NaN	NaN	NaN	NaN	17	40	---	---							
UNC5CL	222643	broad.mit.edu	37	6	40996310	40996316	+	Frame_Shift_Del	DEL	GGGGCTG	GGGGCTG	-			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr6:40996310_40996316delGGGGCTG	uc003opi.2	-	9	1442_1448	c.1353_1359delCAGCCCC	c.(1351-1359)CGCAGCCCCfs	p.R451fs		NM_173561	NP_775832	Q8IV45	UN5CL_HUMAN	unc-5 homolog C-like	451_453	Death.|Cytoplasmic (Potential).				signal transduction	cytoplasm|integral to membrane				ovary(2)	2	Ovarian(28;0.0418)|Colorectal(47;0.196)					TGGCCGCTGCGGGGCTGCGCTGGCAGG	0.671		NaN											NaN	NaN	NaN	NaN	NaN	12	66	---	---							
MLL3	58508	broad.mit.edu	37	7	151845284	151845288	+	Frame_Shift_Del	DEL	GAAGA	GAAGA	-			TCGA-FD-A3SM-01A-11D-A22Z-08	TCGA-FD-A3SM-10A-01D-A22Z-08			GAAGA	-	GAAGA	GAAGA		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	357a748c-0c33-4408-b31f-dc7f0375031d	6f6c0555-16e2-4b99-8f40-07197d272e0b	g.chr7:151845284_151845288delGAAGA	uc003wla.2	-	52	13943_13947	c.13724_13728delTCTTC	c.(13723-13728)CTCTTCfs	p.L4575fs	MLL3_uc003wkz.2_Frame_Shift_Del_p.L3693fs|MLL3_uc003wkx.2_Frame_Shift_Del_p.L733fs|MLL3_uc003wky.2_Frame_Shift_Del_p.L2139fs	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	4575_4576	FYR N-terminal.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		AGCCCACAGGGAAGAGTGCTTTAGG	0.566		NaN	N		medulloblastoma								NaN	NaN	NaN	NaN	NaN	16	41	---	---							
