Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
PLCH2	9651	broad.mit.edu	37	1	2419057	2419057	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:2419057G>A	uc001aji.1	+	8	1409	c.1135G>A	c.(1135-1137)GAC>AAC	p.D379N	PLCH2_uc010nyz.1_Missense_Mutation_p.D167N|PLCH2_uc009vle.1_Missense_Mutation_p.D167N|PLCH2_uc001ajj.1_Missense_Mutation_p.D167N|PLCH2_uc001ajk.1_Missense_Mutation_p.D167N	NM_014638	NP_055453	O75038	PLCH2_HUMAN	phospholipase C, eta 2	379	PI-PLC X-box.				intracellular signal transduction|lipid catabolic process	cytoplasm|plasma membrane	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			central_nervous_system(3)|ovary(1)|skin(1)	5	all_cancers(77;0.000161)|all_epithelial(69;5.98e-05)|all_lung(157;0.016)|Lung NSC(156;0.0376)|Ovarian(185;0.0634)	all_epithelial(116;7.32e-16)|all_lung(118;1.15e-06)|Lung NSC(185;6.26e-05)|Renal(390;0.00571)|Breast(487;0.00832)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Medulloblastoma(700;0.151)|Lung SC(97;0.217)		Epithelial(90;1.44e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.78e-23)|GBM - Glioblastoma multiforme(42;2.8e-08)|Colorectal(212;4.19e-05)|COAD - Colon adenocarcinoma(227;0.000195)|Kidney(185;0.00034)|BRCA - Breast invasive adenocarcinoma(365;0.00443)|KIRC - Kidney renal clear cell carcinoma(229;0.00548)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.2)		GGATGGGCCCGACGGGGAGCC	0.567		NaN											0	0	0	1	0	4	25									
RHCE	6006	broad.mit.edu	37	1	25729193	25729193	+	Missense_Mutation	SNP	G	G	A	rs1053346		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:25729193G>A	uc001bkf.2	-	3	466	c.380C>T	c.(379-381)GCG>GTG	p.A127V	RHCE_uc001bkg.2_Missense_Mutation_p.A127V|RHCE_uc001bkh.2_Missense_Mutation_p.A127V|RHCE_uc001bki.2_Missense_Mutation_p.A127V|RHCE_uc001bkj.2_Missense_Mutation_p.A111V	NM_020485	NP_065231	P18577	RHCE_HUMAN	Rhesus blood group, CcEe antigens isoform 1	127	Helical; (Potential).					integral to plasma membrane					0		Colorectal(325;3.46e-05)|Lung NSC(340;0.000245)|all_lung(284;0.000335)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0101)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0426)|OV - Ovarian serous cystadenocarcinoma(117;2.12e-27)|Colorectal(126;3.16e-08)|COAD - Colon adenocarcinoma(152;1.72e-06)|STAD - Stomach adenocarcinoma(196;0.00035)|KIRC - Kidney renal clear cell carcinoma(1967;0.000769)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|GBM - Glioblastoma multiforme(114;0.00458)|READ - Rectum adenocarcinoma(331;0.0649)		GACAGCACCCGCTGAGATCAG	0.537		NaN											0	0	0	1	0	23	31									
MACF1	23499	broad.mit.edu	37	1	39824382	39824382	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:39824382G>C	uc010oiu.1	+	10	7408	c.7277G>C	c.(7276-7278)GGA>GCA	p.G2426A	MACF1_uc010ois.1_Missense_Mutation_p.G1924A|MACF1_uc001cda.1_Missense_Mutation_p.G1832A|MACF1_uc001cdc.1_Missense_Mutation_p.G1011A|MACF1_uc001cdb.1_Missense_Mutation_p.G1011A	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	3991					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			ACACGATTAGGATCTCACCTG	0.502		NaN											0	0	0	1	0	16	38									
MACF1	23499	broad.mit.edu	37	1	39824525	39824525	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:39824525G>C	uc010oiu.1	+	10	7551	c.7420G>C	c.(7420-7422)GAG>CAG	p.E2474Q	MACF1_uc010ois.1_Missense_Mutation_p.E1972Q|MACF1_uc001cda.1_Missense_Mutation_p.E1880Q|MACF1_uc001cdc.1_Missense_Mutation_p.E1059Q|MACF1_uc001cdb.1_Missense_Mutation_p.E1059Q	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	4039	Spectrin 2.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGTTCTCCAGGAGCAGCTTGC	0.512		NaN											0	0	0	1	0	15	42									
MACF1	23499	broad.mit.edu	37	1	39824885	39824885	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:39824885G>A	uc010oiu.1	+	11	7644	c.7513G>A	c.(7513-7515)GAA>AAA	p.E2505K	MACF1_uc010ois.1_Missense_Mutation_p.E2003K|MACF1_uc001cda.1_Missense_Mutation_p.E1911K|MACF1_uc001cdc.1_Missense_Mutation_p.E1090K|MACF1_uc001cdb.1_Missense_Mutation_p.E1090K	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	4070	Spectrin 2.				cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TGACATAATGGAAATTGAAGG	0.423		NaN											0	0	0	1	0	16	62									
ZMPSTE24	10269	broad.mit.edu	37	1	40737653	40737653	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:40737653G>A	uc001cfg.2	+	6	926	c.715G>A	c.(715-717)GAA>AAA	p.E239K		NM_005857	NP_005848	O75844	FACE1_HUMAN	zinc metallopeptidase STE24	239						endoplasmic reticulum membrane|Golgi membrane|integral to membrane	metal ion binding|metalloexopeptidase activity				0	Lung NSC(20;4.38e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;6.3e-18)			AGAAGAAATTGAAGTAATGGC	0.373		NaN											0	0	0	1	0	18	90									
IPO13	9670	broad.mit.edu	37	1	44424184	44424184	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:44424184C>T	uc001ckx.2	+	10	2596	c.1801C>T	c.(1801-1803)CTT>TTT	p.L601F		NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	601	HEAT 10.				protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				GCTGTCAGCTCTTCAAGTGGA	0.552		NaN											0	0	0	1	0	9	96									
FOXD2	2306	broad.mit.edu	37	1	47904362	47904362	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:47904362C>G	uc001crm.2	+	1	2674	c.555C>G	c.(553-555)TTC>TTG	p.F185L		NM_004474	NP_004465	O60548	FOXD2_HUMAN	forkhead box D2	185	Fork-head.				axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0				READ - Rectum adenocarcinoma(2;0.0908)		ACGACTGCTTCGTCAAGATCC	0.637		NaN											0	0	0	1	0	28	81									
INADL	10207	broad.mit.edu	37	1	62263049	62263049	+	Nonsense_Mutation	SNP	C	C	T	rs117405402	byFrequency	TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:62263049C>T	uc001dab.2	+	11	1465	c.1351C>T	c.(1351-1353)CGA>TGA	p.R451*	INADL_uc009waf.1_Nonsense_Mutation_p.R451*|INADL_uc001daa.2_Nonsense_Mutation_p.R451*|INADL_uc001dad.3_Nonsense_Mutation_p.R148*	NM_176877	NP_795352	Q8NI35	INADL_HUMAN	InaD-like	451	PDZ 3.				intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			ovary(3)|skin(1)	4						AACCCTAGTTCGAAGGAAGAC	0.448		NaN											0	0	0	1	0	33	84									
PDE4B	5142	broad.mit.edu	37	1	66834533	66834533	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:66834533C>T	uc001dcn.2	+	16	1917	c.1726C>T	c.(1726-1728)CGG>TGG	p.R576W	PDE4B_uc009war.2_Missense_Mutation_p.R484W|PDE4B_uc001dco.2_Missense_Mutation_p.R576W|PDE4B_uc001dcp.2_Missense_Mutation_p.R561W|PDE4B_uc001dcq.2_Missense_Mutation_p.R404W|PDE4B_uc009was.2_Missense_Mutation_p.R343W	NM_001037341	NP_001032418	Q07343	PDE4B_HUMAN	phosphodiesterase 4B isoform 1	576					signal transduction	cytosol|insoluble fraction|soluble fraction	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			ovary(2)|central_nervous_system(1)	3					Adenosine monophosphate(DB00131)|Amrinone(DB01427)|Caffeine(DB00201)|Cilostazol(DB01166)|Dyphylline(DB00651)|Enprofylline(DB00824)|Papaverine(DB01113)|Pentoxifylline(DB00806)|Theophylline(DB00277)	GGAATTGTATCGGCAATGGAC	0.463		NaN											0	0	0	1	0	16	70									
SERBP1	26135	broad.mit.edu	37	1	67890585	67890585	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:67890585G>A	uc001ddv.2	-	4	821	c.681C>T	c.(679-681)GTC>GTT	p.V227V	SERBP1_uc001ddx.2_Silent_p.V221V|SERBP1_uc001ddy.2_Silent_p.V221V|SERBP1_uc001ddw.2_Silent_p.V227V	NM_001018067	NP_001018077	Q8NC51	PAIRB_HUMAN	SERPINE1 mRNA binding protein 1 isoform 1	227					regulation of mRNA stability	nucleus|perinuclear region of cytoplasm	mRNA 3'-UTR binding|protein binding			skin(1)	1						ATTCGTCTTTGACAGTTCCCC	0.368		NaN											0	0	0	1	0	34	59									
LRRC7	57554	broad.mit.edu	37	1	70504079	70504079	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:70504079C>T	uc001dep.2	+	19	2488	c.2458C>T	c.(2458-2460)CCC>TCC	p.P820S	LRRC7_uc009wbg.2_Missense_Mutation_p.P104S|LRRC7_uc001deq.2_Missense_Mutation_p.P61S	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	820						centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						TGTTGGTGTTCCCCTGGAACT	0.493		NaN											0	0	0	1	0	29	59									
GBP5	115362	broad.mit.edu	37	1	89735197	89735197	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:89735197G>A	uc001dnc.2	-	3	579	c.42C>T	c.(40-42)ATC>ATT	p.I14I	GBP5_uc001dnd.2_Silent_p.I14I|GBP5_uc001dne.1_Silent_p.I14I	NM_052942	NP_443174	Q96PP8	GBP5_HUMAN	guanylate-binding protein 5	14						plasma membrane	GTP binding|GTPase activity			ovary(1)	1				all cancers(265;0.00784)|Epithelial(280;0.0286)		TAAAGTTCTCGATGAGGCACA	0.478		NaN											0	0	0	1	0	44	132									
BRDT	676	broad.mit.edu	37	1	92459724	92459724	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:92459724C>T	uc001dok.3	+	15	2549	c.2200C>T	c.(2200-2202)CAC>TAC	p.H734Y	BRDT_uc001dol.3_Missense_Mutation_p.H734Y|BRDT_uc010osz.1_Missense_Mutation_p.H738Y|BRDT_uc009wdf.2_Missense_Mutation_p.H661Y|BRDT_uc010ota.1_Missense_Mutation_p.H688Y|BRDT_uc010otb.1_Missense_Mutation_p.H688Y|BRDT_uc001dom.3_Missense_Mutation_p.H734Y	NM_207189	NP_997072	Q58F21	BRDT_HUMAN	testis-specific bromodomain protein	734					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein serine/threonine kinase activity|transcription coactivator activity			stomach(2)|ovary(1)|lung(1)	4		all_lung(203;0.00531)|Lung NSC(277;0.0194)		all cancers(265;0.0228)|Epithelial(280;0.133)		GCCACCAAATCACCACCAATT	0.363		NaN											0	0	0	1	0	18	83									
DNTTIP2	30836	broad.mit.edu	37	1	94343201	94343201	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:94343201G>A	uc001dqf.2	-	2	328	c.290C>T	c.(289-291)TCT>TTT	p.S97F	DNTTIP2_uc010otm.1_RNA|DNTTIP2_uc009wdo.1_Intron	NM_014597	NP_055412	Q5QJE6	TDIF2_HUMAN	deoxynucleotidyltransferase, terminal,	97					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_lung(203;0.0111)|Lung NSC(277;0.0347)		all cancers(265;0.00679)|GBM - Glioblastoma multiforme(16;0.0278)|Epithelial(280;0.128)		ATGGTGCTCAGACACAGAATA	0.458		NaN											0	0	0	1	0	11	42									
AGL	178	broad.mit.edu	37	1	100358047	100358047	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:100358047G>T	uc001dsi.1	+	24	3543	c.3143G>T	c.(3142-3144)TGT>TTT	p.C1048F	AGL_uc001dsj.1_Missense_Mutation_p.C1048F|AGL_uc001dsk.1_Missense_Mutation_p.C1048F|AGL_uc001dsl.1_Missense_Mutation_p.C1048F|AGL_uc001dsm.1_Missense_Mutation_p.C1032F|AGL_uc001dsn.1_Missense_Mutation_p.C1031F	NM_000642	NP_000633	P35573	GDE_HUMAN	amylo-1,6-glucosidase,	1048	4-alpha-glucanotransferase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol|isoamylase complex|nucleus	4-alpha-glucanotransferase activity|amylo-alpha-1,6-glucosidase activity|cation binding			ovary(1)|central_nervous_system(1)|skin(1)	3		all_epithelial(167;2.2e-06)|all_lung(203;0.000295)|Lung NSC(277;0.00131)		Epithelial(280;0.15)|COAD - Colon adenocarcinoma(174;0.151)|Lung(183;0.209)|all cancers(265;0.237)		GTTCAACTGTGTGGAGTAGGA	0.368		NaN											1	0	2.32078e-09	1	2.41399e-09	15	40									
CCDC76	54482	broad.mit.edu	37	1	100614274	100614274	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:100614274C>T	uc001dsv.2	+	11	1363	c.1344C>T	c.(1342-1344)TTC>TTT	p.F448F	CCDC76_uc010ouf.1_RNA|CCDC76_uc009wea.2_3'UTR	NM_019083	NP_061956	Q9NUP7	TRM13_HUMAN	coiled-coil domain containing 76	448					tRNA processing		metal ion binding|methyltransferase activity			ovary(1)	1		all_epithelial(167;0.000542)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0814)|all cancers(265;0.133)|COAD - Colon adenocarcinoma(174;0.146)|Lung(183;0.194)		AGAAGGGATTCAGTCCTGCTT	0.383		NaN											0	0	0	1	0	16	63									
EXTL2	2135	broad.mit.edu	37	1	101343047	101343047	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:101343047C>T	uc001dtk.1	-	3	755	c.418G>A	c.(418-420)GAA>AAA	p.E140K	EXTL2_uc001dtl.1_Missense_Mutation_p.E140K|EXTL2_uc010ouk.1_Missense_Mutation_p.E127K|EXTL2_uc001dtm.1_Missense_Mutation_p.E140K	NM_001439	NP_001430	Q9UBQ6	EXTL2_HUMAN	exostoses-like 2	140	Lumenal (Potential).				N-acetylglucosamine metabolic process|UDP-N-acetylgalactosamine metabolic process	extracellular region|integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,4-N-acetylgalactosaminyltransferase activity|glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity|metal ion binding			skin(1)	1		all_epithelial(167;2.48e-06)|all_lung(203;0.000414)|Lung NSC(277;0.000946)		Epithelial(280;0.0425)|all cancers(265;0.0628)|COAD - Colon adenocarcinoma(174;0.148)|Colorectal(144;0.167)|Lung(183;0.195)		GTTTCCAGTTCAGGAAAGACC	0.488		NaN											0	0	0	1	0	13	48									
KCNA3	3738	broad.mit.edu	37	1	111216259	111216259	+	Silent	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:111216259C>G	uc001dzv.1	-	1	1397	c.1173G>C	c.(1171-1173)CTG>CTC	p.L391L		NM_002232	NP_002223	P22001	KCNA3_HUMAN	potassium voltage-gated channel, shaker-related	391						voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(4)|pancreas(1)	5		all_cancers(81;3.92e-06)|all_epithelial(167;1.28e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000398)		Lung(183;0.0235)|Colorectal(144;0.0306)|all cancers(265;0.0752)|Epithelial(280;0.0821)|COAD - Colon adenocarcinoma(174;0.132)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGGACGCCTTCAGCGTTTGCC	0.587		NaN											0	0	0	1	0	28	83									
PTPN22	26191	broad.mit.edu	37	1	114380755	114380755	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:114380755C>T	uc001eds.2	-	13	1397	c.1267G>A	c.(1267-1269)GAG>AAG	p.E423K	PTPN22_uc009wgq.2_Missense_Mutation_p.E368K|PTPN22_uc010owo.1_Missense_Mutation_p.E179K|PTPN22_uc001edt.2_Intron|PTPN22_uc009wgr.2_Missense_Mutation_p.E423K|PTPN22_uc009wgs.2_Missense_Mutation_p.E296K|PTPN22_uc001edu.2_Missense_Mutation_p.E423K	NM_015967	NP_057051	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type	423					negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			kidney(2)|lung(1)|skin(1)	4	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAACATCCCTCAAACAAAAGA	0.388		NaN											0	0	0	1	0	19	51									
HSD3B2	3284	broad.mit.edu	37	1	119962079	119962079	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:119962079G>C	uc001ehs.2	+	2	954	c.181G>C	c.(181-183)GAC>CAC	p.D61H	HSD3B2_uc001eht.2_Missense_Mutation_p.D61H|HSD3B2_uc001ehu.2_Missense_Mutation_p.D61H	NM_000198	NP_000189	P26439	3BHS2_HUMAN	3 beta-hydroxysteroid dehydrogenase 2	61					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	ACTTGAAGGAGACATTCTGGA	0.493		NaN											0	0	0	1	0	11	35									
HSD3B2	3284	broad.mit.edu	37	1	119965133	119965133	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:119965133C>G	uc001ehs.2	+	3	1782	c.1009C>G	c.(1009-1011)CTG>GTG	p.L337V	HSD3B2_uc001eht.2_Missense_Mutation_p.L337V|HSD3B2_uc001ehu.2_Intron	NM_000198	NP_000189	P26439	3BHS2_HUMAN	3 beta-hydroxysteroid dehydrogenase 2	337					androgen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.015)|LUSC - Lung squamous cell carcinoma(189;0.0836)	NADH(DB00157)|Trilostane(DB01108)	TCAGCGAGATCTGGCGTATAA	0.512		NaN											0	0	0	1	0	14	47									
HSD3B1	3283	broad.mit.edu	37	1	120056980	120056980	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:120056980C>T	uc001ehv.1	+	4	979	c.834C>T	c.(832-834)CTC>CTT	p.L278L	HSD3B1_uc001ehw.2_Silent_p.L280L	NM_000862	NP_000853	P14060	3BHS1_HUMAN	3 beta-hydroxysteroid dehydrogenase 1	278					androgen biosynthetic process|estrogen biosynthetic process|glucocorticoid biosynthetic process|mineralocorticoid biosynthetic process	integral to membrane|microsome|mitochondrial inner membrane|mitochondrial intermembrane space|smooth endoplasmic reticulum membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|steroid delta-isomerase activity			ovary(2)	2	all_neural(166;0.219)	all_lung(203;3.16e-06)|Lung NSC(69;2.19e-05)|all_epithelial(167;0.000624)		Lung(183;0.0106)|LUSC - Lung squamous cell carcinoma(189;0.0554)	NADH(DB00157)|Trilostane(DB01108)	AGTTCGGCCTCCGCCTTGATT	0.473		NaN											0	0	0	1	0	8	152									
ADAM30	11085	broad.mit.edu	37	1	120438233	120438233	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:120438233C>T	uc001eij.2	-	1	881	c.727G>A	c.(727-729)GAT>AAT	p.D243N		NM_021794	NP_068566	Q9UKF2	ADA30_HUMAN	ADAM metallopeptidase domain 30 preproprotein	243	Peptidase M12B.|Extracellular (Potential).				proteolysis	integral to membrane	metalloendopeptidase activity|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(5;7.07e-10)|all_epithelial(5;1.62e-10)|all_neural(166;0.153)|Breast(55;0.234)	all_lung(203;1.55e-06)|Lung NSC(69;1.04e-05)|all_epithelial(167;0.00138)		Lung(183;0.0204)|LUSC - Lung squamous cell carcinoma(189;0.117)		ATACGAACATCTTGAAAGTAG	0.368		NaN											0	0	0	1	0	23	70									
PDE4DIP	9659	broad.mit.edu	37	1	144857639	144857639	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:144857639C>G	uc001elw.3	-	39	6706	c.6415G>C	c.(6415-6417)GAA>CAA	p.E2139Q	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.E2033Q|PDE4DIP_uc001elv.3_Missense_Mutation_p.E1146Q	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	2139					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		ATGGGCGTTTCTGAGCCAGGA	0.488		NaN	T	PDGFRB	MPD								0	0	0	1	0	12	254									
TXNIP	10628	broad.mit.edu	37	1	145439622	145439622	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:145439622G>A	uc001enn.3	+	2	621	c.280G>A	c.(280-282)GGA>AGA	p.G94R	NBPF10_uc001emp.3_Intron|TXNIP_uc001enm.1_Intron|TXNIP_uc010oys.1_Missense_Mutation_p.G39R	NM_006472	NP_006463	Q9H3M7	TXNIP_HUMAN	thioredoxin interacting protein	94					cell cycle|keratinocyte differentiation|transcription, DNA-dependent		ubiquitin protein ligase binding			ovary(2)	2	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CATGAGACCTGGAAACAAATA	0.398		NaN											0	0	0	1	0	33	122									
ANKRD35	148741	broad.mit.edu	37	1	145567755	145567755	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:145567755G>A	uc001eob.1	+	13	3113	c.3005G>A	c.(3004-3006)TGA>TAA	p.*1002*	NBPF10_uc001emp.3_Intron	NM_144698	NP_653299	Q8N283	ANR35_HUMAN	ankyrin repeat domain 35	1002										ovary(4)|skin(1)	5	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					GAAGAGGAGTGAGGCAGCCTC	0.478		NaN											0	0	0	1	0	39	117									
ECM1	1893	broad.mit.edu	37	1	150484937	150484937	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:150484937G>A	uc001eus.2	+	8	1392	c.1193G>A	c.(1192-1194)CGT>CAT	p.R398H	ECM1_uc001eut.2_Missense_Mutation_p.R273H|ECM1_uc001euu.2_Missense_Mutation_p.R427H|ECM1_uc001euv.2_Missense_Mutation_p.R425H|ECM1_uc009wlu.2_Missense_Mutation_p.R158H	NM_004425	NP_004416	Q16610	ECM1_HUMAN	extracellular matrix protein 1 isoform 1	398	2 X approximate repeats.|2.				angiogenesis|biomineral tissue development|negative regulation of bone mineralization|negative regulation of peptidase activity|ossification|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade	proteinaceous extracellular matrix	laminin binding|protease binding|protein C-terminus binding|signal transducer activity			ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.29e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			TGCTTTGCCCGTCGGGCTCCT	0.567		NaN											0	0	0	1	0	23	104									
FAM63A	55793	broad.mit.edu	37	1	150972348	150972348	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:150972348G>A	uc001ewf.2	-	7	2512	c.828C>T	c.(826-828)CTC>CTT	p.L276L	FAM63A_uc001ewc.2_Silent_p.L134L|FAM63A_uc010pcm.1_Silent_p.L181L|FAM63A_uc001ewd.2_Silent_p.L134L|FAM63A_uc001ewe.2_Silent_p.L110L|FAM63A_uc010pcn.1_Silent_p.L324L|FAM63A_uc001ewg.2_Silent_p.L276L	NM_018379	NP_001156731	Q8N5J2	FA63A_HUMAN	hypothetical protein LOC55793 isoform 1	276							protein binding			ovary(1)	1	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CTTCTGTCACGAGGTTGGTGT	0.418		NaN											0	0	0	1	0	8	39									
MTX1	4580	broad.mit.edu	37	1	155181948	155181948	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:155181948C>T	uc001fjb.2	+	4	815	c.709C>T	c.(709-711)CGG>TGG	p.R237W	RAG1AP1_uc010pey.1_Intron|THBS3_uc001fja.2_5'Flank|THBS3_uc009wqj.1_5'Flank|MTX1_uc001fjc.2_Intron	NM_002455	NP_002446	Q13505	MTX1_HUMAN	metaxin 1 isoform 1	237					protein targeting to mitochondrion	integral to membrane|mitochondrial outer membrane	protein binding			skin(1)	1	all_epithelial(22;5.72e-28)|all_lung(78;2.07e-24)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)		Epithelial(20;3.72e-10)|all cancers(21;1.19e-09)|BRCA - Breast invasive adenocarcinoma(34;0.000752)|LUSC - Lung squamous cell carcinoma(543;0.193)			TCTGTCAGCTCGGCAAGGGGC	0.577		NaN											0	0	0	1	0	7	80									
ASH1L	55870	broad.mit.edu	37	1	155340407	155340407	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:155340407C>T	uc009wqq.2	-	12	7069	c.6589G>A	c.(6589-6591)GAC>AAC	p.D2197N	RAG1AP1_uc010pey.1_Intron|ASH1L_uc001fkt.2_Missense_Mutation_p.D2192N	NM_018489	NP_060959	Q9NR48	ASH1L_HUMAN	absent, small, or homeotic 1-like	2197	SET.				cell-cell signaling|DNA packaging|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	chromosome|Golgi apparatus|nucleus|tight junction	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	11	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)		Epithelial(20;1.74e-08)|all cancers(21;3.29e-08)|BRCA - Breast invasive adenocarcinoma(34;0.021)			CAGTAGTGGTCACTGTGATTA	0.408		NaN											0	0	0	1	0	21	95									
MSTO1	55154	broad.mit.edu	37	1	155582954	155582954	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:155582954G>A	uc001fky.2	+	11	1246	c.1213G>A	c.(1213-1215)GAG>AAG	p.E405K	MSTO1_uc001fkw.2_Missense_Mutation_p.E405K|MSTO1_uc001fkx.2_Missense_Mutation_p.E405K|MSTO1_uc001fla.2_Missense_Mutation_p.E224K|MSTO1_uc001fkz.2_Missense_Mutation_p.E336K|MSTO1_uc001fld.3_Missense_Mutation_p.E227K|MSTO1_uc009wqs.2_Missense_Mutation_p.E284K|MSTO1_uc010pgf.1_Missense_Mutation_p.E350K|MSTO1_uc001flb.2_Missense_Mutation_p.E274K|MSTO1_uc001flc.2_Missense_Mutation_p.E227K	NM_018116	NP_060586	Q9BUK6	MSTO1_HUMAN	misato	405					mitochondrion distribution|protein polymerization	mitochondrial outer membrane|protein complex					0	Hepatocellular(266;0.0997)|all_neural(408;0.129)|all_hematologic(923;0.145)					TGCATGTGGGGAGCCTTCTGG	0.567		NaN											0	0	0	1	0	19	84									
GON4L	54856	broad.mit.edu	37	1	155784175	155784175	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:155784175C>G	uc001flz.2	-	9	1324	c.1227G>C	c.(1225-1227)TTG>TTC	p.L409F	GON4L_uc001fly.1_Missense_Mutation_p.L409F|GON4L_uc009wrh.1_Missense_Mutation_p.L409F|GON4L_uc001fma.1_Missense_Mutation_p.L409F|GON4L_uc001fmc.2_Missense_Mutation_p.L409F|GON4L_uc001fmd.3_Missense_Mutation_p.L409F|GON4L_uc009wri.2_5'UTR|GON4L_uc001fme.2_Missense_Mutation_p.L237F|GON4L_uc001fmf.2_Missense_Mutation_p.L103F	NM_001037533	NP_001032622	Q3T8J9	GON4L_HUMAN	gon-4-like isoform a	409					regulation of transcription, DNA-dependent	cytoplasm|nucleus	DNA binding			ovary(3)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)|all_neural(408;0.195)					AAGACTGCCTCAATCTGGATT	0.393		NaN											0	0	0	1	0	24	107									
ETV3	2117	broad.mit.edu	37	1	157105486	157105486	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:157105486C>T	uc001fqr.2	-	3	350	c.61G>A	c.(61-63)GAC>AAC	p.D21N	ETV3_uc001fqt.2_Missense_Mutation_p.D21N	NM_001145312	NP_001138784	P41162	ETV3_HUMAN	ets variant gene 3 isoform 1	21							sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Hepatocellular(266;0.158)	Prostate(1639;0.174)				TAGGCCCAGTCAGGAAACTGA	0.507		NaN											0	0	0	1	0	26	79									
SPTA1	6708	broad.mit.edu	37	1	158647509	158647509	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:158647509C>T	uc001fst.1	-	7	1127	c.928G>A	c.(928-930)GAG>AAG	p.E310K		NM_003126	NP_003117	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1	310	Spectrin 4.				actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|breast(1)	8	all_hematologic(112;0.0378)					AGATTTCTCTCAAGTCCCTTG	0.453		NaN											0	0	0	1	0	12	39									
ATP1A2	477	broad.mit.edu	37	1	160097482	160097482	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:160097482G>A	uc001fvc.2	+	8	1021	c.889G>A	c.(889-891)GCT>ACT	p.A297T	ATP1A2_uc001fvb.2_Missense_Mutation_p.A297T|ATP1A2_uc010piz.1_Missense_Mutation_p.A142T|ATP1A2_uc001fvd.2_Missense_Mutation_p.A33T|ATP1A2_uc009wtg.1_5'Flank	NM_000702	NP_000693	P50993	AT1A2_HUMAN	Na+/K+ -ATPase alpha 2 subunit proprotein	297	Helical; (Potential).				ATP biosynthetic process		ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			central_nervous_system(3)|ovary(2)|skin(2)	7	all_cancers(52;1.11e-16)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)|LUSC - Lung squamous cell carcinoma(543;0.246)			CACAGGGGTCGCTGTATTCCT	0.577		NaN											0	0	0	1	0	36	141									
ADCY10	55811	broad.mit.edu	37	1	167798547	167798547	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:167798547C>T	uc001ger.2	-	26	4006	c.3708G>A	c.(3706-3708)ATG>ATA	p.M1236I	ADCY10_uc009wvj.2_RNA|ADCY10_uc009wvk.2_Missense_Mutation_p.M1144I|ADCY10_uc010plj.1_Missense_Mutation_p.M1083I	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	1236					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						TCATTTGCATCATAACTGCCA	0.413		NaN											0	0	0	1	0	26	89									
FMO3	2328	broad.mit.edu	37	1	171083364	171083364	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:171083364G>A	uc001ghi.2	+	7	1156	c.1045G>A	c.(1045-1047)GAG>AAG	p.E349K	FMO3_uc001ghh.2_Missense_Mutation_p.E349K|FMO3_uc010pmb.1_Missense_Mutation_p.E329K|FMO3_uc010pmc.1_Missense_Mutation_p.E286K	NM_001002294	NP_001002294	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	349					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CAGAAACAATGAGATCATTTT	0.428		NaN											0	0	0	1	0	26	59									
PRDX6	9588	broad.mit.edu	37	1	173455466	173455466	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:173455466G>A	uc001giy.1	+	4	523	c.472G>A	c.(472-474)GAT>AAT	p.D158N		NM_004905	NP_004896	P30041	PRDX6_HUMAN	peroxiredoxin 6	158	Thioredoxin.				cell redox homeostasis|phospholipid catabolic process	cytoplasmic membrane-bounded vesicle|cytosol|lysosome	peroxiredoxin activity|phospholipase A2 activity|protein binding			central_nervous_system(1)	1						CAGGAACTTTGATGAGATTCT	0.443		NaN											0	0	0	1	0	55	181									
RC3H1	149041	broad.mit.edu	37	1	173952637	173952637	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:173952637G>C	uc001gju.3	-	3	598	c.511C>G	c.(511-513)CTC>GTC	p.L171V	RC3H1_uc010pms.1_Missense_Mutation_p.L171V|RC3H1_uc001gjv.2_Missense_Mutation_p.L171V|RC3H1_uc010pmt.1_Missense_Mutation_p.L171V	NM_172071	NP_742068	Q5TC82	RC3H1_HUMAN	roquin	171					cytoplasmic mRNA processing body assembly|negative regulation of activated T cell proliferation|negative regulation of B cell proliferation|negative regulation of germinal center formation|negative regulation of T-helper cell differentiation|nuclear-transcribed mRNA catabolic process|regulation of mRNA stability|regulation of T cell receptor signaling pathway	cytoplasmic mRNA processing body|stress granule	mRNA 3'-UTR binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						TGGTGCTGGAGAATGAGCTCT	0.483		NaN											0	0	0	1	0	20	85									
ASTN1	460	broad.mit.edu	37	1	176833621	176833621	+	Silent	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:176833621G>C	uc001glc.2	-	23	3896	c.3684C>G	c.(3682-3684)CTC>CTG	p.L1228L	ASTN1_uc001glb.1_Intron	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	1236					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						ACCAACTGCTGAGGTCCCCAA	0.522		NaN											0	0	0	1	0	15	52									
ARPC5	10092	broad.mit.edu	37	1	183599601	183599601	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:183599601C>T	uc001gql.2	-	3	579	c.388G>A	c.(388-390)GAA>AAA	p.E130K		NM_005717	NP_005708	O15511	ARPC5_HUMAN	actin related protein 2/3 complex subunit 5	130					actin cytoskeleton organization|cellular component movement|regulation of actin filament polymerization	Arp2/3 protein complex|cell projection|cytoplasm	actin binding|structural constituent of cytoskeleton				0						CTTACCTTTTCATGCCATTGC	0.348		NaN											0	0	0	1	0	12	53									
RGL1	23179	broad.mit.edu	37	1	183853908	183853908	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:183853908C>T	uc001gqo.2	+	7	944	c.787C>T	c.(787-789)CGA>TGA	p.R263*	RGL1_uc010pof.1_Nonsense_Mutation_p.R68*|RGL1_uc001gqm.2_Nonsense_Mutation_p.R298*|RGL1_uc010pog.1_Nonsense_Mutation_p.R261*|RGL1_uc010poh.1_Nonsense_Mutation_p.R261*|RGL1_uc010poi.1_Nonsense_Mutation_p.R263*	NM_015149	NP_055964	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation	263	Ras-GEF.				cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|ovary(4)|lung(2)	11						CATTTGGTCTCGAAGGGATAA	0.458		NaN											0	0	0	1	0	22	68									
GLT25D2	23127	broad.mit.edu	37	1	183920242	183920242	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:183920242G>A	uc001gqr.2	-	8	1407	c.1035C>T	c.(1033-1035)TTC>TTT	p.F345F	GLT25D2_uc010poj.1_Silent_p.F345F|GLT25D2_uc001gqq.2_Silent_p.F82F|GLT25D2_uc001gqs.2_Silent_p.F225F	NM_015101	NP_055916	Q8IYK4	GT252_HUMAN	glycosyltransferase 25 domain containing 2	345					lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen	procollagen galactosyltransferase activity			ovary(1)|breast(1)	2						GGTTTATCATGAAAATCTAAT	0.403		NaN											0	0	0	1	0	72	109									
PRG4	10216	broad.mit.edu	37	1	186281364	186281364	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:186281364G>A	uc001gru.3	+	11	3902	c.3851G>A	c.(3850-3852)AGA>AAA	p.R1284K	PRG4_uc001grt.3_Missense_Mutation_p.R1243K|PRG4_uc009wyl.2_Missense_Mutation_p.R1191K|PRG4_uc009wym.2_Missense_Mutation_p.R1150K|PRG4_uc010poo.1_RNA|TPR_uc001grv.2_3'UTR	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	1284					cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						TGCCCTGGAAGAAGGCCTGCT	0.403		NaN											0	0	0	1	0	57	71									
TPR	7175	broad.mit.edu	37	1	186313156	186313156	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:186313156G>C	uc001grv.2	-	26	3781	c.3484C>G	c.(3484-3486)CAG>GAG	p.Q1162E		NM_003292	NP_003283	P12270	TPR_HUMAN	nuclear pore complex-associated protein TPR	1162	Potential.				carbohydrate metabolic process|glucose transport|mitotic cell cycle spindle assembly checkpoint|mRNA transport|protein import into nucleus|regulation of glucose transport|seryl-tRNA aminoacylation|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytoplasm|nuclear membrane|nuclear pore|nucleoplasm	ATP binding|protein binding|serine-tRNA ligase activity			ovary(2)|lung(2)|urinary_tract(1)|central_nervous_system(1)|skin(1)	7		Breast(1374;0.000659)|Lung SC(1967;0.0262)|Prostate(1639;0.157)		Colorectal(1306;1.12e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00553)		TTTTCGATCTGATCATGAAGT	0.393		NaN	T	NTRK1	papillary thyroid								0	0	0	1	0	10	48									
KCNT2	343450	broad.mit.edu	37	1	196397285	196397285	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:196397285C>G	uc001gtd.1	-	10	994	c.934G>C	c.(934-936)GAT>CAT	p.D312H	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Missense_Mutation_p.D312H|KCNT2_uc001gtf.1_Missense_Mutation_p.D312H|KCNT2_uc001gtg.1_Intron|KCNT2_uc009wyu.2_Missense_Mutation_p.D312H|KCNT2_uc009wyv.1_Missense_Mutation_p.D287H	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	312	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						ATAAGTAAATCAATCTTCAGT	0.373		NaN											0	0	0	1	0	20	72									
CFHR2	3080	broad.mit.edu	37	1	196928035	196928035	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:196928035T>C	uc001gtq.1	+	5	715	c.638T>C	c.(637-639)ATT>ACT	p.I213T	CFHR2_uc001gtr.1_Missense_Mutation_p.I89T	NM_005666	NP_005657	P36980	FHR2_HUMAN	H factor (complement)-like 3 precursor	213	Sushi 4.					extracellular region				skin(2)|ovary(1)	3						TCACAAGAAATTATGGAAAAA	0.274		NaN											0	0	0	1	0	8	31									
CHIT1	1118	broad.mit.edu	37	1	203191375	203191375	+	Silent	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:203191375G>C	uc001gzn.2	-	7	780	c.684C>G	c.(682-684)CTC>CTG	p.L228L	FMOD_uc010pqi.1_Intron|CHIT1_uc001gzm.1_RNA|CHIT1_uc009xal.1_Silent_p.L19L|CHIT1_uc009xam.1_RNA|CHIT1_uc009xan.1_RNA|CHIT1_uc001gzo.2_Silent_p.L219L	NM_003465	NP_003456	Q13231	CHIT1_HUMAN	chitotriosidase precursor	228					chitin catabolic process|immune response|response to bacterium	extracellular space|lysosome	cation binding|chitin binding|endochitinase activity				0						GCCTCTTGTAGAGGGGGCTGT	0.577		NaN											0	0	0	1	0	19	54									
ATP2B4	493	broad.mit.edu	37	1	203693083	203693083	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:203693083C>T	uc001gzw.2	+	19	3983	c.3099C>T	c.(3097-3099)CTC>CTT	p.L1033L	ATP2B4_uc001gzv.2_Silent_p.L1033L|ATP2B4_uc009xaq.2_Silent_p.L1033L|ATP2B4_uc001gzx.2_Silent_p.L64L|ATP2B4_uc009xar.2_Intron	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	1033	Helical; (Potential).				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			TGTGGTGTCTCTTCATTGGGA	0.532		NaN											0	0	0	1	0	24	100									
TLR5	7100	broad.mit.edu	37	1	223285449	223285449	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:223285449C>T	uc001hnv.1	-	4	1371	c.925G>A	c.(925-927)GAG>AAG	p.E309K	TLR5_uc001hnw.1_Missense_Mutation_p.E309K	NM_003268	NP_003259	O60602	TLR5_HUMAN	toll-like receptor 5 precursor	309	Extracellular (Potential).|LRR 5.				cellular response to mechanical stimulus|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of interleukin-8 production|positive regulation of toll-like receptor signaling pathway	integral to membrane|plasma membrane	interleukin-1 receptor binding|transmembrane receptor activity			ovary(2)|lung(1)|skin(1)	4				GBM - Glioblastoma multiforme(131;0.0851)		TTGAGTGTCTCAAAGACTCGT	0.443		NaN											0	0	0	1	0	51	62									
PARP1	142	broad.mit.edu	37	1	226566910	226566910	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:226566910C>G	uc001hqd.3	-	12	1849	c.1678G>C	c.(1678-1680)GTG>CTG	p.V560L		NM_001618	NP_001609	P09874	PARP1_HUMAN	poly (ADP-ribose) polymerase family, member 1	560					cellular response to insulin stimulus|protein ADP-ribosylation|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nuclear envelope|nucleolus|transcription factor complex	DNA binding|identical protein binding|NAD+ ADP-ribosyltransferase activity|protein N-terminus binding|transcription factor binding|zinc ion binding			lung(3)|ovary(2)|breast(2)|skin(2)|upper_aerodigestive_tract(1)	10	Breast(184;0.133)			GBM - Glioblastoma multiforme(131;0.0531)		ACGATGTCCACCAGGCCAAGG	0.527		NaN						Direct_reversal_of_damage|PARP_enzymes_that_bind_to_DNA					0	0	0	1	0	59	109									
ACTN2	88	broad.mit.edu	37	1	236908074	236908074	+	Silent	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:236908074C>G	uc001hyf.2	+	12	1608	c.1404C>G	c.(1402-1404)CTC>CTG	p.L468L	ACTN2_uc001hyg.2_Silent_p.L260L|ACTN2_uc009xgi.1_Silent_p.L468L|ACTN2_uc010pxu.1_Silent_p.L157L|ACTN2_uc001hyh.2_Silent_p.L156L	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	468	Spectrin 2.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			CGCAGGAGCTCAAGTATGTGC	0.647		NaN											0	0	0	1	0	12	48									
OR1C1	26188	broad.mit.edu	37	1	247920938	247920938	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:247920938G>A	uc010pza.1	-	1	771	c.771C>T	c.(769-771)GCC>GCT	p.A257A		NM_012353	NP_036485	Q15619	OR1C1_HUMAN	olfactory receptor, family 1, subfamily C,	257	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;4.34e-05)|all_epithelial(71;1.13e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0786)|Lung NSC(105;0.0858)	all_cancers(173;0.0247)	OV - Ovarian serous cystadenocarcinoma(106;0.0168)			TGAAATAGACGGCGATGGCTG	0.512		NaN											0	0	0	1	0	25	53									
OR2M5	127059	broad.mit.edu	37	1	248308805	248308805	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr1:248308805C>G	uc010pze.1	+	1	356	c.356C>G	c.(355-357)TCT>TGT	p.S119C		NM_001004690	NP_001004690	A3KFT3	OR2M5_HUMAN	olfactory receptor, family 2, subfamily M,	119	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|kidney(1)	3	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0388)			GCTGTTATGTCTTATGACCGC	0.453		NaN											0	0	0	1	0	116	354									
SFMBT2	57713	broad.mit.edu	37	10	7262479	7262479	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:7262479G>A	uc009xio.1	-	11	1315	c.1224C>T	c.(1222-1224)TTC>TTT	p.F408F	SFMBT2_uc001ijn.1_Silent_p.F408F|SFMBT2_uc010qay.1_Intron	NM_001029880	NP_001025051	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	408	MBT 4.				regulation of transcription, DNA-dependent	nucleus				ovary(4)|upper_aerodigestive_tract(2)|large_intestine(1)|central_nervous_system(1)	8						TGTTCTTTGTGAAACCTCGAC	0.502		NaN											0	0	0	1	0	18	70									
ARHGAP12	94134	broad.mit.edu	37	10	32097634	32097634	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:32097634C>A	uc001ivz.1	-	19	2579	c.2309G>T	c.(2308-2310)AGA>ATA	p.R770I	ARHGAP12_uc001ivy.1_Missense_Mutation_p.R716I|ARHGAP12_uc009xls.2_Missense_Mutation_p.R721I|ARHGAP12_uc001iwb.1_Missense_Mutation_p.R763I|ARHGAP12_uc001iwc.1_Missense_Mutation_p.R738I|ARHGAP12_uc009xlq.1_Missense_Mutation_p.R691I|ARHGAP12_uc001ivw.1_5'Flank|ARHGAP12_uc001ivx.1_Missense_Mutation_p.R69I	NM_018287	NP_060757	Q8IWW6	RHG12_HUMAN	Rho GTPase activating protein 12	770	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity				0		Prostate(175;0.0199)				TGGCAACTGTCTGATTAGGTC	0.388		NaN											1	0	2.74695e-27	1	2.91582e-27	47	136									
MAPK8	5599	broad.mit.edu	37	10	49633961	49633961	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:49633961A>G	uc009xnz.2	+	8	943	c.719A>G	c.(718-720)CAG>CGG	p.Q240R	MAPK8_uc001jgl.2_Missense_Mutation_p.Q240R|MAPK8_uc001jgm.2_Missense_Mutation_p.Q240R|MAPK8_uc001jgo.2_Missense_Mutation_p.Q240R|MAPK8_uc009xoa.2_Intron|MAPK8_uc001jgn.2_Missense_Mutation_p.Q240R|MAPK8_uc010qgk.1_Missense_Mutation_p.Q240R|MAPK8_uc001jgp.2_Missense_Mutation_p.Q240R|MAPK8_uc001jgq.2_Missense_Mutation_p.Q240R	NM_139047	NP_620635	P45983	MK08_HUMAN	mitogen-activated protein kinase 8 isoform JNK1	240	Protein kinase.				activation of pro-apoptotic gene products|cellular response to mechanical stimulus|induction of apoptosis by intracellular signals|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of apoptosis|negative regulation of protein binding|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of deacetylase activity|regulation of protein localization|regulation of sequence-specific DNA binding transcription factor activity|response to UV|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|histone deacetylase binding|histone deacetylase regulator activity|JUN kinase activity|protein binding			central_nervous_system(3)|lung(2)|stomach(1)|ovary(1)|kidney(1)	8		Ovarian(717;0.0221)|Lung SC(717;0.113)|all_neural(218;0.116)		Epithelial(53;3.46e-65)|Lung(62;0.125)		GTTATTGAACAGCTTGGAACA	0.318		NaN											0	0	0	1	0	9	44									
A1CF	29974	broad.mit.edu	37	10	52619618	52619618	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:52619618C>G	uc001jjj.2	-	3	271	c.83G>C	c.(82-84)GGA>GCA	p.G28A	A1CF_uc010qhn.1_5'UTR|A1CF_uc001jji.2_Missense_Mutation_p.G28A|A1CF_uc001jjh.2_5'UTR|A1CF_uc010qho.1_5'UTR|A1CF_uc009xov.2_Missense_Mutation_p.G28A|A1CF_uc001jjk.1_Missense_Mutation_p.G28A	NM_138932	NP_620310	Q9NQ94	A1CF_HUMAN	apobec-1 complementation factor isoform 2	28					cytidine to uridine editing|mRNA modification|mRNA processing|protein stabilization	apolipoprotein B mRNA editing enzyme complex|endoplasmic reticulum|nucleoplasm	nucleotide binding|protein binding|single-stranded RNA binding			central_nervous_system(1)	1						CAAGCTATATCCTGTGCGCTG	0.498		NaN											0	0	0	1	0	15	43									
CDH23	64072	broad.mit.edu	37	10	73326687	73326687	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:73326687C>T	uc001jrx.3	+	7	995	c.618C>T	c.(616-618)AAC>AAT	p.N206N	CDH23_uc001jrw.3_Silent_p.N206N|CDH23_uc001jrv.2_Silent_p.N201N|CDH23_uc009xql.2_Silent_p.N251N	NM_022124	NP_071407	Q9H251	CAD23_HUMAN	cadherin-like 23 isoform 1 precursor	206	Cadherin 2.|Extracellular (Potential).				calcium ion transport|calcium-dependent cell-cell adhesion|cytosolic calcium ion homeostasis|equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	cytosol|integral to membrane|plasma membrane|stereocilium	calcium ion binding|protein binding			central_nervous_system(5)|large_intestine(4)|ovary(2)	11						TCACGGTCAACGCCACAGTGA	0.627		NaN											0	0	0	1	0	4	24									
KIF20B	9585	broad.mit.edu	37	10	91487639	91487639	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:91487639G>C	uc001kgs.1	+	17	2329	c.2257G>C	c.(2257-2259)GAG>CAG	p.E753Q	KIF20B_uc001kgr.1_Missense_Mutation_p.E713Q|KIF20B_uc001kgt.1_5'UTR	NM_016195	NP_057279	Q96Q89	KI20B_HUMAN	M-phase phosphoprotein 1	753	Potential.			E -> K (in Ref. 1; BAB69456).	cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			ovary(1)|pancreas(1)|skin(1)	3						TCAAGAGCTTGAGACATCTAA	0.244		NaN											0	0	0	1	0	4	21									
CRTAC1	55118	broad.mit.edu	37	10	99770957	99770957	+	Silent	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:99770957G>C	uc001kou.1	-	2	518	c.162C>G	c.(160-162)CTC>CTG	p.L54L	CRTAC1_uc001kov.2_Silent_p.L43L	NM_018058	NP_060528	Q9NQ79	CRAC1_HUMAN	cartilage acidic protein 1 precursor	54	FG-GAP 1; atypical.					proteinaceous extracellular matrix	calcium ion binding			ovary(4)|pancreas(1)	5		Colorectal(252;0.24)		Epithelial(162;2.18e-10)|all cancers(201;3.27e-09)		CACCATAGTTGAGCTGGGTGG	0.537		NaN											0	0	0	1	0	35	83									
C10orf28	27291	broad.mit.edu	37	10	99969078	99969078	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:99969078G>C	uc001kow.3	+	4	1502	c.1207G>C	c.(1207-1209)GAT>CAT	p.D403H	C10orf28_uc001kox.3_Missense_Mutation_p.D403H|C10orf28_uc001koy.3_Missense_Mutation_p.D403H|C10orf28_uc009xvx.2_Missense_Mutation_p.D403H|C10orf28_uc009xvy.2_Intron|C10orf28_uc001koz.3_Intron	NM_014472	NP_055287	Q4KMY3	Q4KMY3_HUMAN	growth inhibition and differentiation related	403							nucleotide binding			large_intestine(1)|skin(1)	2		Colorectal(252;0.234)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)		TAGAATAGCTGATGAGACCTC	0.398		NaN											0	0	0	1	0	41	100									
CHUK	1147	broad.mit.edu	37	10	101981902	101981902	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:101981902C>G	uc001kqp.2	-	4	407	c.352G>C	c.(352-354)GAA>CAA	p.E118Q		NM_001278	NP_001269	O15111	IKKA_HUMAN	conserved helix-loop-helix ubiquitous kinase	118	Protein kinase.				I-kappaB phosphorylation|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cytosol|internal side of plasma membrane|nucleus	ATP binding|identical protein binding|IkappaB kinase activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|lung(1)|breast(1)	7		Colorectal(252;0.117)		Epithelial(162;2.05e-10)|all cancers(201;1.91e-08)		ATCTGGCTTTCTTTAAGTCCA	0.348		NaN											0	0	0	1	0	4	24									
KCNIP2	30819	broad.mit.edu	37	10	103587157	103587157	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:103587157C>A	uc001kub.2	-	10	1118	c.766G>T	c.(766-768)GAT>TAT	p.D256Y	KCNIP2_uc010qqg.1_Missense_Mutation_p.D200Y|KCNIP2_uc001ktx.2_RNA|KCNIP2_uc001kty.2_Missense_Mutation_p.D154Y|KCNIP2_uc001ktz.2_Missense_Mutation_p.D211Y|KCNIP2_uc009xwu.2_Missense_Mutation_p.D205Y|KCNIP2_uc009xwv.2_Missense_Mutation_p.D202Y|KCNIP2_uc001kuc.2_Missense_Mutation_p.D271Y|KCNIP2_uc001kue.2_Missense_Mutation_p.D238Y|KCNIP2_uc001kud.2_Missense_Mutation_p.D213Y|KCNIP2_uc001kuf.2_Missense_Mutation_p.D206Y|KCNIP2_uc001kua.2_Missense_Mutation_p.D187Y|KCNIP2_uc009xww.2_RNA	NM_173191	NP_775283	Q9NS61	KCIP2_HUMAN	Kv channel interacting protein 2 isoform 2	256	EF-hand 4.				clustering of voltage-gated potassium channels|detection of calcium ion|muscle contraction|regulation of heart contraction|signal transduction|synaptic transmission	cytoplasm|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|calcium ion binding|ER retention sequence binding|identical protein binding|protein N-terminus binding				0		Colorectal(252;0.122)		Epithelial(162;4.93e-09)|all cancers(201;2.63e-07)		ATGTTCTCATCCTGTGGCCAT	0.522		NaN											1	0	1.55469e-16	1	1.62693e-16	25	111									
KCNIP2	30819	broad.mit.edu	37	10	103587660	103587660	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:103587660C>G	uc001kub.2	-	8	1040	c.688G>C	c.(688-690)GAG>CAG	p.E230Q	KCNIP2_uc010qqg.1_Missense_Mutation_p.E174Q|KCNIP2_uc001ktx.2_RNA|KCNIP2_uc001kty.2_Missense_Mutation_p.E128Q|KCNIP2_uc001ktz.2_Missense_Mutation_p.E185Q|KCNIP2_uc009xwu.2_Missense_Mutation_p.E180Q|KCNIP2_uc009xwv.2_Missense_Mutation_p.E176Q|KCNIP2_uc001kuc.2_Missense_Mutation_p.E245Q|KCNIP2_uc001kue.2_Missense_Mutation_p.E212Q|KCNIP2_uc001kud.2_Missense_Mutation_p.E187Q|KCNIP2_uc001kuf.2_Missense_Mutation_p.E180Q|KCNIP2_uc001kua.2_Missense_Mutation_p.E161Q|KCNIP2_uc009xww.2_RNA|KCNIP2_uc010qqh.1_Missense_Mutation_p.E185Q|KCNIP2_uc010qqi.1_Missense_Mutation_p.E144Q	NM_173191	NP_775283	Q9NS61	KCIP2_HUMAN	Kv channel interacting protein 2 isoform 2	230	EF-hand 4.				clustering of voltage-gated potassium channels|detection of calcium ion|muscle contraction|regulation of heart contraction|signal transduction|synaptic transmission	cytoplasm|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|calcium ion binding|ER retention sequence binding|identical protein binding|protein N-terminus binding				0		Colorectal(252;0.122)		Epithelial(162;4.93e-09)|all cancers(201;2.63e-07)		AAGAAGCTCTCCACGTGTTCC	0.557		NaN											0	0	0	1	0	15	58									
KCNIP2	30819	broad.mit.edu	37	10	103588900	103588900	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:103588900C>G	uc001kub.2	-	4	632	c.280G>C	c.(280-282)GAG>CAG	p.E94Q	KCNIP2_uc010qqg.1_5'Flank|KCNIP2_uc001ktx.2_RNA|KCNIP2_uc001kty.2_Missense_Mutation_p.W15C|KCNIP2_uc001ktz.2_Missense_Mutation_p.E49Q|KCNIP2_uc009xwu.2_Missense_Mutation_p.E44Q|KCNIP2_uc009xwv.2_Missense_Mutation_p.E44Q|KCNIP2_uc001kuc.2_Missense_Mutation_p.E109Q|KCNIP2_uc001kue.2_Missense_Mutation_p.E76Q|KCNIP2_uc001kud.2_Missense_Mutation_p.E44Q|KCNIP2_uc001kuf.2_Missense_Mutation_p.E44Q|KCNIP2_uc001kua.2_Missense_Mutation_p.W15C|KCNIP2_uc009xww.2_RNA|KCNIP2_uc010qqh.1_Missense_Mutation_p.E49Q|KCNIP2_uc010qqi.1_Missense_Mutation_p.E44Q	NM_173191	NP_775283	Q9NS61	KCIP2_HUMAN	Kv channel interacting protein 2 isoform 2	94	EF-hand 1; degenerate.				clustering of voltage-gated potassium channels|detection of calcium ion|muscle contraction|regulation of heart contraction|signal transduction|synaptic transmission	cytoplasm|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|calcium ion binding|ER retention sequence binding|identical protein binding|protein N-terminus binding				0		Colorectal(252;0.122)		Epithelial(162;4.93e-09)|all cancers(201;2.63e-07)		TGCAGCTGCTCCAGACCCTCA	0.617		NaN											0	0	0	1	0	10	28									
PPRC1	23082	broad.mit.edu	37	10	103900787	103900787	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:103900787C>T	uc001kum.2	+	5	2561	c.2522C>T	c.(2521-2523)TCA>TTA	p.S841L	PPRC1_uc001kun.2_Missense_Mutation_p.S721L|PPRC1_uc010qqj.1_Missense_Mutation_p.S841L|PPRC1_uc009xxa.2_RNA	NM_015062	NP_055877	Q5VV67	PPRC1_HUMAN	peroxisome proliferator-activated receptor	841	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.122)		Epithelial(162;4.97e-08)|all cancers(201;8.99e-07)		CCTGTGGCCTCATCTCCCACT	0.597		NaN											0	0	0	1	0	33	49									
SLK	9748	broad.mit.edu	37	10	105780291	105780291	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:105780291C>T	uc001kxo.1	+	17	3401	c.3367C>T	c.(3367-3369)CAG>TAG	p.Q1123*	SLK_uc001kxp.1_Nonsense_Mutation_p.Q1092*	NM_014720	NP_055535	Q9H2G2	SLK_HUMAN	serine/threonine kinase 2	1123	Potential.				apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			ovary(2)|stomach(2)|skin(2)|lung(1)|kidney(1)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		GAGAATGGCTCAGCATCAGAA	0.393		NaN											0	0	0	1	0	12	46									
SLK	9748	broad.mit.edu	37	10	105780327	105780327	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:105780327C>A	uc001kxo.1	+	17	3437	c.3403C>A	c.(3403-3405)CAG>AAG	p.Q1135K	SLK_uc001kxp.1_Missense_Mutation_p.Q1104K	NM_014720	NP_055535	Q9H2G2	SLK_HUMAN	serine/threonine kinase 2	1135	Potential.				apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			ovary(2)|stomach(2)|skin(2)|lung(1)|kidney(1)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		GCGAGATCTTCAGTTGCAGTG	0.453		NaN											1	0	3.41278e-10	1	3.55698e-10	15	56									
GFRA1	2674	broad.mit.edu	37	10	117884737	117884737	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:117884737G>C	uc001lcj.2	-	6	1463	c.765C>G	c.(763-765)ATC>ATG	p.I255M	GFRA1_uc001lci.2_Missense_Mutation_p.I250M|GFRA1_uc009xyr.2_Missense_Mutation_p.I250M	NM_005264	NP_005255	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1 isoform a	255	3.				axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			ovary(1)|pancreas(1)	2		Lung NSC(174;0.21)		all cancers(201;0.0337)		CTTACCTGCAGATGTAATTCG	0.537		NaN											0	0	0	1	0	16	26									
PDZD8	118987	broad.mit.edu	37	10	119134253	119134253	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:119134253G>A	uc001lde.1	-	1	685	c.486C>T	c.(484-486)CTC>CTT	p.L162L		NM_173791	NP_776152	Q8NEN9	PDZD8_HUMAN	PDZ domain containing 8	162					intracellular signal transduction		metal ion binding				0		Colorectal(252;0.19)		all cancers(201;0.0121)		CTGGCCGCACGAGCCGGATGG	0.731		NaN											0	0	0	1	0	4	17									
BCCIP	56647	broad.mit.edu	37	10	127512238	127512238	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:127512238G>A	uc001ljb.3	+	1	135	c.112G>A	c.(112-114)GAC>AAC	p.D38N	BCCIP_uc001ljd.3_Missense_Mutation_p.D38N|UROS_uc001lix.3_5'Flank|UROS_uc001liy.3_5'Flank|BCCIP_uc010qui.1_Missense_Mutation_p.D38N|BCCIP_uc001ljc.3_Missense_Mutation_p.D38N|BCCIP_uc010quj.1_Missense_Mutation_p.D38N	NM_078468	NP_510868	Q9P287	BCCIP_HUMAN	BRCA2 and CDKN1A-interacting protein isoform	38					cell cycle|DNA repair|neuroendocrine cell differentiation|regulation of cyclin-dependent protein kinase activity	nuclear cyclin-dependent protein kinase holoenzyme complex	kinase regulator activity|protein binding			ovary(1)|breast(1)	2		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)				tgaggatgaagacgatgatga	0.343		NaN											0	0	0	1	0	5	59									
BCCIP	56647	broad.mit.edu	37	10	127512271	127512271	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:127512271G>A	uc001ljb.3	+	1	168	c.145G>A	c.(145-147)GAG>AAG	p.E49K	BCCIP_uc001ljd.3_Missense_Mutation_p.E49K|UROS_uc001lix.3_5'Flank|UROS_uc001liy.3_5'Flank|BCCIP_uc010qui.1_Missense_Mutation_p.E49K|BCCIP_uc001ljc.3_Missense_Mutation_p.E49K|BCCIP_uc010quj.1_Missense_Mutation_p.E49K	NM_078468	NP_510868	Q9P287	BCCIP_HUMAN	BRCA2 and CDKN1A-interacting protein isoform	49					cell cycle|DNA repair|neuroendocrine cell differentiation|regulation of cyclin-dependent protein kinase activity	nuclear cyclin-dependent protein kinase holoenzyme complex	kinase regulator activity|protein binding			ovary(1)|breast(1)	2		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)				aaaggatgaagaggacgaggT	0.308		NaN											0	0	0	1	0	10	53									
BCCIP	56647	broad.mit.edu	37	10	127512277	127512277	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr10:127512277G>A	uc001ljb.3	+	1	174	c.151G>A	c.(151-153)GAG>AAG	p.E51K	BCCIP_uc001ljd.3_Missense_Mutation_p.E51K|UROS_uc001lix.3_5'Flank|UROS_uc001liy.3_5'Flank|BCCIP_uc010qui.1_Missense_Mutation_p.E51K|BCCIP_uc001ljc.3_Missense_Mutation_p.E51K|BCCIP_uc010quj.1_Missense_Mutation_p.E51K	NM_078468	NP_510868	Q9P287	BCCIP_HUMAN	BRCA2 and CDKN1A-interacting protein isoform	51					cell cycle|DNA repair|neuroendocrine cell differentiation|regulation of cyclin-dependent protein kinase activity	nuclear cyclin-dependent protein kinase holoenzyme complex	kinase regulator activity|protein binding			ovary(1)|breast(1)	2		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)				tgaagaggacgaggTCATTGA	0.303		NaN											0	0	0	1	0	9	52									
DUSP8	1850	broad.mit.edu	37	11	1586886	1586886	+	Silent	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:1586886C>G	uc001lts.2	-	2	299	c.171G>C	c.(169-171)CGG>CGC	p.R57R		NM_004420	NP_004411	Q13202	DUS8_HUMAN	dual specificity phosphatase 8	57	Rhodanese.				inactivation of MAPK activity	cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0		all_epithelial(84;0.000134)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.000621)|Lung(200;0.0687)|LUSC - Lung squamous cell carcinoma(625;0.0825)		GCTGCAGCCGCCGCTTCACCA	0.647		NaN											0	0	0	1	0	18	42									
UBQLNL	143630	broad.mit.edu	37	11	5537271	5537271	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:5537271C>G	uc001maz.3	-	1	686	c.401G>C	c.(400-402)AGA>ACA	p.R134T	HBG2_uc001mak.1_Intron	NM_145053	NP_659490	Q8IYU4	UBQLN_HUMAN	ubiquilin-like	134										large_intestine(2)|skin(1)	3		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.92e-09)|BRCA - Breast invasive adenocarcinoma(625;0.136)		TTGGTGCACTCTGCTGCTGTT	0.537		NaN											0	0	0	1	0	17	55									
OR52E4	390081	broad.mit.edu	37	11	5905783	5905783	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:5905783C>G	uc010qzs.1	+	1	261	c.261C>G	c.(259-261)TTC>TTG	p.F87L	TRIM5_uc001mbq.1_Intron	NM_001005165	NP_001005165	Q8NGH9	O52E4_HUMAN	olfactory receptor, family 52, subfamily E,	87	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.24e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TAGGAATCTTCTGGTTCAACC	0.458		NaN											0	0	0	1	0	40	106									
PIK3C2A	5286	broad.mit.edu	37	11	17112890	17112890	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:17112890G>A	uc001mmq.3	-	31	4935	c.4869C>T	c.(4867-4869)TTC>TTT	p.F1623F	PIK3C2A_uc009ygu.1_Silent_p.F226F|PIK3C2A_uc010rcw.1_Silent_p.F1243F|PIK3C2A_uc001mmr.3_Intron	NM_002645	NP_002636	O00443	P3C2A_HUMAN	phosphoinositide-3-kinase, class 2 alpha	1623	C2.				cell communication|phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling	clathrin-coated vesicle|Golgi apparatus|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity			lung(4)|central_nervous_system(4)|stomach(1)|ovary(1)	10					Phosphatidylserine(DB00144)	CCATTTCATTGAATGTCGGAT	0.249		NaN											0	0	0	1	0	18	57									
NELL1	4745	broad.mit.edu	37	11	21581919	21581919	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:21581919C>T	uc001mqe.2	+	17	2124	c.1971C>T	c.(1969-1971)TGC>TGT	p.C657C	NELL1_uc001mqf.2_Silent_p.C610C|NELL1_uc009yid.2_Silent_p.C685C|NELL1_uc010rdo.1_Silent_p.C600C|NELL1_uc010rdp.1_Silent_p.C370C|NELL1_uc001mqh.2_Intron	NM_006157	NP_006148	Q92832	NELL1_HUMAN	nel-like 1 isoform 1 precursor	657	VWFC 3.				cell adhesion|nervous system development	extracellular region	calcium ion binding|structural molecule activity			ovary(2)|large_intestine(1)	3						GTTCTGTCTGCTCCTGCAAGG	0.542		NaN											0	0	0	1	0	14	20									
KIF18A	81930	broad.mit.edu	37	11	28104452	28104452	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:28104452C>T	uc001msc.2	-	9	1395	c.1213G>A	c.(1213-1215)GAC>AAC	p.D405N		NM_031217	NP_112494	Q8NI77	KI18A_HUMAN	kinesin family member 18A	405	Potential.				blood coagulation|microtubule depolymerization|microtubule-based movement|mitotic metaphase plate congression|mitotic prometaphase|protein transport	caveola|cytosol|kinetochore microtubule|microtubule organizing center|nucleus|ruffle	actin binding|ATP binding|microtubule plus-end binding|plus-end-directed microtubule motor activity|tubulin-dependent ATPase activity|ubiquitin binding			ovary(2)	2						TTTGCTTGGTCATTTTCATTA	0.264		NaN											0	0	0	1	0	4	34									
TTC17	55761	broad.mit.edu	37	11	43380573	43380573	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:43380573C>T	uc001mxi.2	+	1	83	c.69C>T	c.(67-69)CTC>CTT	p.L23L	TTC17_uc001mxh.2_Silent_p.L23L	NM_018259	NP_060729	Q96AE7	TTC17_HUMAN	tetratricopeptide repeat domain 17	23							binding			ovary(5)	5						GCTGGCTCCTCAGCCTTTCCG	0.711		NaN											0	0	0	1	0	4	7									
OR4B1	119765	broad.mit.edu	37	11	48238743	48238743	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:48238743C>G	uc010rhs.1	+	1	382	c.382C>G	c.(382-384)CTT>GTT	p.L128V		NM_001005470	NP_001005470	Q8NGF8	OR4B1_HUMAN	olfactory receptor, family 4, subfamily B,	128	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)|pancreas(1)	4						TTGCAAGCCTCTTCATTATAT	0.453		NaN											0	0	0	1	0	41	87									
OR4C6	219432	broad.mit.edu	37	11	55433227	55433227	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:55433227C>T	uc001nht.3	+	3	850	c.585C>T	c.(583-585)CTC>CTT	p.L195L	OR4C6_uc010rik.1_Silent_p.L195L	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	195	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						TCCTGGGCCTCTTAGTTACCC	0.443		NaN											0	0	0	1	0	35	78									
MS4A7	58475	broad.mit.edu	37	11	60154219	60154219	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:60154219C>T	uc001npe.2	+	4	457	c.312C>T	c.(310-312)ATC>ATT	p.I104I	MS4A7_uc001npf.2_Silent_p.I104I|MS4A7_uc001npg.2_Silent_p.I59I|MS4A7_uc001nph.2_Silent_p.I59I|MS4A14_uc001npi.2_Intron|MS4A7_uc009ymx.1_Silent_p.I59I	NM_206939	NP_996822	Q9GZW8	MS4A7_HUMAN	membrane-spanning 4-domains, subfamily A, member	104	Helical; (Potential).					integral to membrane	receptor activity			ovary(1)|central_nervous_system(1)	2						TCTCAATTATCTCTGGAAAAC	0.284		NaN											0	0	0	1	0	24	55									
EML3	256364	broad.mit.edu	37	11	62378910	62378910	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:62378910G>A	uc001ntu.1	-	2	489	c.181C>T	c.(181-183)CCT>TCT	p.P61S	EML3_uc001ntr.1_Missense_Mutation_p.P32S|EML3_uc001nts.1_Missense_Mutation_p.P32S|EML3_uc001ntt.1_5'UTR|EML3_uc010rly.1_Missense_Mutation_p.P61S|EML3_uc009yny.1_5'Flank|ROM1_uc001ntv.2_5'Flank	NM_153265	NP_694997	Q32P44	EMAL3_HUMAN	echinoderm microtubule associated protein like	61						cytoplasm|microtubule	protein binding			ovary(1)	1						TCCCCCGGAGGAGCTGGTGTG	0.602		NaN											0	0	0	1	0	8	30									
ATG2A	23130	broad.mit.edu	37	11	64670063	64670063	+	Silent	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:64670063G>C	uc001obx.2	-	27	3817	c.3702C>G	c.(3700-3702)CTC>CTG	p.L1234L	ATG2A_uc001obw.2_5'UTR	NM_015104	NP_055919	Q2TAZ0	ATG2A_HUMAN	autophagy related 2A	1234							protein binding			ovary(1)|central_nervous_system(1)	2						TTACGTACTGGAGCAGGTTGA	0.652		NaN											0	0	0	1	0	4	10									
ADRBK1	156	broad.mit.edu	37	11	67052909	67052909	+	Silent	SNP	C	C	T	rs144172325		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:67052909C>T	uc009yrn.1	+	21	2324	c.2058C>T	c.(2056-2058)GCC>GCT	p.A686A	ADRBK1_uc009yrm.1_Intron	NM_001619	NP_001610	P25098	ARBK1_HUMAN	beta-adrenergic receptor kinase 1	686					activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	alpha-2A adrenergic receptor binding|ATP binding|beta-adrenergic receptor kinase activity|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|signal transducer activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)	GCGGCAGTGCCAACGGCCTCT	0.542		NaN											0	0	0	1	0	7	16									
C11orf24	53838	broad.mit.edu	37	11	68029775	68029775	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:68029775G>A	uc001onr.3	-	4	1130	c.688C>T	c.(688-690)CGT>TGT	p.R230C	C11orf24_uc001ons.2_Missense_Mutation_p.R230C	NM_022338	NP_071733	Q96F05	CK024_HUMAN	hypothetical protein LOC53838 precursor	230	Extracellular (Potential).|Pro-rich.					integral to membrane					0						GGACTTGGACGAGTGCTCATG	0.587		NaN											0	0	0	1	0	20	60									
MRGPRF	116535	broad.mit.edu	37	11	68773667	68773667	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:68773667C>T	uc001ooo.3	-	3	478	c.111G>A	c.(109-111)CAG>CAA	p.Q37Q	MRGPRF_uc001oop.3_Silent_p.Q37Q	NM_001098515	NP_001091985	Q96AM1	MRGRF_HUMAN	MAS-related GPR, member F	37	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GCATCGCGATCTGCTCGATGG	0.642		NaN											0	0	0	1	0	11	31									
PRKRIR	5612	broad.mit.edu	37	11	76066699	76066699	+	Splice_Site	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:76066699C>G	uc001oxh.1	-	4	319	c.319_splice	c.e4-1	p.S107_splice	PRKRIR_uc010rrz.1_5'UTR	NM_004705	NP_004696	O43422	P52K_HUMAN	protein-kinase, interferon-inducible double						negative regulation of cell proliferation|response to stress|signal transduction		DNA binding|metal ion binding|protein dimerization activity			ovary(2)|pancreas(1)	3						CATCTTCACTCTAAATGTCAA	0.323		NaN											0	0	0	1	0	3	8									
CAPN5	726	broad.mit.edu	37	11	76795973	76795973	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:76795973C>T	uc001oxx.2	+	2	226	c.41C>T	c.(40-42)TCA>TTA	p.S14L	CAPN5_uc009yup.2_Missense_Mutation_p.S14L|CAPN5_uc009yuq.2_Missense_Mutation_p.S50L|CAPN5_uc001oxy.2_Missense_Mutation_p.S54L	NM_004055	NP_004046	O15484	CAN5_HUMAN	calpain 5	14					proteolysis|signal transduction	intracellular	calcium-dependent cysteine-type endopeptidase activity				0						CAGAACTACTCAGCCCTGAGG	0.637		NaN											0	0	0	1	0	11	31									
EED	8726	broad.mit.edu	37	11	85977176	85977176	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:85977176C>T	uc001pbp.2	+	8	1235	c.778C>T	c.(778-780)CTT>TTT	p.L260F	EED_uc010rtm.1_Missense_Mutation_p.L260F|EED_uc001pbq.2_Missense_Mutation_p.L260F|EED_uc001pbr.2_Missense_Mutation_p.L260F|EED_uc001pbs.2_Intron|EED_uc010rtn.1_RNA	NM_003797	NP_003788	O75530	EED_HUMAN	embryonic ectoderm development isoform a	260	Interaction with EZH2 (By similarity).|WD 4.|Required for interaction with the matrix protein MA of HIV-1.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|identical protein binding			skin(1)|pancreas(1)	2		Acute lymphoblastic leukemia(157;7.24e-07)|all_hematologic(158;0.00092)				GGATCATTCTCTTAAACTTTG	0.289		NaN											0	0	0	1	0	53	101									
MAML2	84441	broad.mit.edu	37	11	96074933	96074933	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:96074933G>C	uc001pfw.1	-	1	1412	c.127C>G	c.(127-129)CGG>GGG	p.R43G		NM_032427	NP_115803	Q8IZL2	MAML2_HUMAN	mastermind-like 2	43					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC1/MAML2(516)|CRTC3/MAML2(26)	salivary_gland(500)|lung(36)|thyroid(4)|breast(3)|skin(2)|ovary(1)	546		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				ACAGCGATCCGAGCCCGGAGG	0.657		NaN	T	MECT1|CRTC3	salivary gland mucoepidermoid						OREG0021305	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	6	9									
MAML2	84441	broad.mit.edu	37	11	96074994	96074994	+	Silent	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:96074994G>C	uc001pfw.1	-	1	1351	c.66C>G	c.(64-66)CTC>CTG	p.L22L		NM_032427	NP_115803	Q8IZL2	MAML2_HUMAN	mastermind-like 2	22					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC1/MAML2(516)|CRTC3/MAML2(26)	salivary_gland(500)|lung(36)|thyroid(4)|breast(3)|skin(2)|ovary(1)	546		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				CCCCTCCAAGGAGCCCCGCCC	0.682		NaN	T	MECT1|CRTC3	salivary gland mucoepidermoid						OREG0021305	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	3	3									
YAP1	10413	broad.mit.edu	37	11	102098267	102098267	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:102098267C>T	uc001pgt.2	+	8	1601	c.1231C>T	c.(1231-1233)CGA>TGA	p.R411*	YAP1_uc001pgs.2_Nonsense_Mutation_p.R361*|YAP1_uc001pgu.2_Nonsense_Mutation_p.R395*|YAP1_uc001pgv.2_Nonsense_Mutation_p.R357*|YAP1_uc010ruo.1_Nonsense_Mutation_p.R233*|YAP1_uc001pgw.2_Nonsense_Mutation_p.R235*|YAP1_uc010rup.1_Nonsense_Mutation_p.R176*	NM_001130145	NP_001123617	P46937	YAP1_HUMAN	Yes-associated protein 1, 65kDa isoform 1	411	Transactivation domain.				cell proliferation|cellular response to gamma radiation|contact inhibition|hippo signaling cascade|regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	cytoplasm|nucleus	protein binding|transcription coactivator activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(1)|lung(1)|central_nervous_system(1)	3	all_cancers(8;0.000575)|all_epithelial(12;0.00564)	Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.00936)	Lung(13;0.245)	BRCA - Breast invasive adenocarcinoma(274;0.0189)		CAGTGTCCCTCGAACCCCAGA	0.433		NaN											0	0	0	1	0	8	17									
LAYN	143903	broad.mit.edu	37	11	111430885	111430885	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:111430885G>A	uc001plr.1	+	8	1187	c.851G>A	c.(850-852)GGA>GAA	p.G284E	LAYN_uc001plp.1_Missense_Mutation_p.G276E|LAYN_uc001plq.1_3'UTR|LAYN_uc001pls.1_3'UTR|LAYN_uc010rwg.1_Missense_Mutation_p.G131E|LAYN_uc010rwh.1_Missense_Mutation_p.G132E	NM_178834	NP_849156	Q6UX15	LAYN_HUMAN	layilin	284	Cytoplasmic (Potential).					cell surface|integral to membrane|ruffle	hyaluronic acid binding|sugar binding				0		all_cancers(61;9.06e-10)|all_epithelial(67;1.34e-05)|Melanoma(852;1.74e-05)|all_hematologic(158;0.000885)|Acute lymphoblastic leukemia(157;0.000966)|Medulloblastoma(222;0.0523)|all_neural(223;0.0663)|Breast(348;0.086)		Epithelial(105;1.5e-06)|BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|all cancers(92;2.45e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0476)		CCTCACCAGGGAAACAGCCCG	0.498		NaN											0	0	0	1	0	13	48									
OR10S1	219873	broad.mit.edu	37	11	123847570	123847570	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:123847570G>A	uc001pzm.1	-	1	829	c.829C>T	c.(829-831)CGC>TGC	p.R277C		NM_001004474	NP_001004474	Q8NGN2	O10S1_HUMAN	olfactory receptor, family 10, subfamily S,	277	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		TCACTGGAGCGAGGCTGCAGG	0.592		NaN											0	0	0	1	0	30	72									
KIRREL3	84623	broad.mit.edu	37	11	126318913	126318913	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr11:126318913C>G	uc001qea.2	-	8	1349	c.988G>C	c.(988-990)GAC>CAC	p.D330H	KIRREL3_uc001qeb.2_Missense_Mutation_p.D330H|KIRREL3_uc001qec.1_Missense_Mutation_p.D330H	NM_032531	NP_115920	Q8IZU9	KIRR3_HUMAN	kin of IRRE like 3 isoform 1	330	Extracellular (Potential).|Ig-like C2-type 3.				hemopoiesis	extracellular region|integral to membrane|plasma membrane	protein binding			ovary(3)	3	all_hematologic(175;0.145)	Lung NSC(97;0.0484)|all_lung(97;0.0522)|Medulloblastoma(222;0.0523)|Breast(109;0.0949)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;6.03e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.12)		CAGTAGACGTCAACCGTGCGG	0.577		NaN											0	0	0	1	0	12	30									
CD163L1	283316	broad.mit.edu	37	12	7526237	7526237	+	Splice_Site	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:7526237C>T	uc001qsy.2	-	14	3436	c.3410_splice	c.e14-1	p.E1137_splice	CD163L1_uc010sge.1_Splice_Site_p.E1147_splice	NM_174941	NP_777601	Q9NR16	C163B_HUMAN	scavenger receptor cysteine-rich type 1							extracellular region|integral to membrane|plasma membrane	scavenger receptor activity			ovary(8)|skin(2)|central_nervous_system(1)	11						GCTGTGAATTCTACAGAGAAA	0.438		NaN											0	0	0	1	0	7	118									
A2M	2	broad.mit.edu	37	12	9225252	9225252	+	Silent	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:9225252G>C	uc001qvk.1	-	30	4085	c.3972C>G	c.(3970-3972)CTC>CTG	p.L1324L	A2M_uc001qvj.1_Silent_p.L366L|A2M_uc009zgk.1_Silent_p.L1174L	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	1324					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	GTCTCACCTGGAGGTAGACAC	0.507		NaN											0	0	0	1	0	50	47									
KLRC3	3823	broad.mit.edu	37	12	10587089	10587089	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:10587089C>T	uc001qyh.2	-	3	334	c.327G>A	c.(325-327)CAG>CAA	p.Q109Q	KLRC2_uc010she.1_Silent_p.Q109Q|KLRC2_uc001qyk.2_Silent_p.Q109Q	NM_002261	NP_002252	Q07444	NKG2E_HUMAN	killer cell lectin-like receptor subfamily C,	109	Extracellular (Potential).				cellular defense response	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|skin(1)	3						ATGTACCTTTCTGCGTTCTTG	0.279		NaN											0	0	0	1	0	13	100									
CDKN1B	1027	broad.mit.edu	37	12	12871794	12871794	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:12871794G>T	uc001rat.2	+	2	983	c.511G>T	c.(511-513)GAA>TAA	p.E171*		NM_004064	NP_004055	P46527	CDN1B_HUMAN	cyclin-dependent kinase inhibitor 1B	171					autophagic cell death|cell cycle arrest|cellular response to lithium ion|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein catabolic process|S phase of mitotic cell cycle	cytosol|endosome|nucleoplasm	cyclin-dependent protein kinase inhibitor activity|protein phosphatase binding|transforming growth factor beta receptor, cytoplasmic mediator activity			ovary(1)|lung(1)	2		Prostate(47;0.0322)|all_epithelial(100;0.159)		BRCA - Breast invasive adenocarcinoma(232;0.0336)		CAACAGAACAGAAGAAAATGT	0.443		NaN							Multiple_Endocrine_Neoplasia_type_1|Multiple_Endocrine_Neoplasia_type_4				1	0	8.28887e-21	1	8.74467e-21	54	47									
SLC11A2	4891	broad.mit.edu	37	12	51389481	51389481	+	Silent	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:51389481G>C	uc001rxe.3	-	10	1018	c.921C>G	c.(919-921)TCC>TCG	p.S307S	SLC11A2_uc001rxd.3_Silent_p.S156S|SLC11A2_uc001rxc.3_Silent_p.S307S|SLC11A2_uc001rxf.2_RNA|SLC11A2_uc001rxg.1_5'Flank|SLC11A2_uc010smx.1_Silent_p.S303S|SLC11A2_uc001rxh.1_Silent_p.S307S|SLC11A2_uc001rxj.1_Silent_p.S307S|SLC11A2_uc001rxi.2_Silent_p.S307S|SLC11A2_uc001rxk.1_Silent_p.S336S|SLC11A2_uc010smy.1_Silent_p.S270S	NM_000617	NP_000608	P49281	NRAM2_HUMAN	solute carrier family 11 (proton-coupled	307	Helical; (Potential).				activation of caspase activity|cellular iron ion homeostasis|cellular response to oxidative stress|detection of oxygen|ferrous iron import|multicellular organismal iron ion homeostasis|response to hypoxia|response to iron ion	apical plasma membrane|basal part of cell|cell surface|cytoplasmic vesicle|early endosome|late endosome|late endosome membrane|lysosomal membrane|lysosome|nucleus|paraferritin complex|perinuclear region of cytoplasm|perinuclear region of cytoplasm|plasma membrane|recycling endosome|trans-Golgi network	cadmium ion transmembrane transporter activity|cadmium ion transmembrane transporter activity|cobalt ion transmembrane transporter activity|copper ion transmembrane transporter activity|ferrous iron transmembrane transporter activity|ferrous iron transmembrane transporter activity|lead ion transmembrane transporter activity|lead ion transmembrane transporter activity|manganese ion transmembrane transporter activity|manganese ion transmembrane transporter activity|nickel ion transmembrane transporter activity|protein binding|solute:hydrogen symporter activity|vanadium ion transmembrane transporter activity|zinc ion transmembrane transporter activity			large_intestine(1)	1						TGATGATGAAGGAAACAAAGA	0.413		NaN											0	0	0	1	0	22	29									
KRT8	3856	broad.mit.edu	37	12	53292539	53292539	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:53292539C>A	uc001sbd.2	-	6	1229	c.1126G>T	c.(1126-1128)GAG>TAG	p.E376*	KRT8_uc009zmj.2_Intron|KRT8_uc009zmk.1_Nonsense_Mutation_p.E404*|KRT8_uc009zml.1_Nonsense_Mutation_p.E376*|KRT8_uc009zmm.1_Nonsense_Mutation_p.E376*	NM_002273	NP_002264	P05787	K2C8_HUMAN	keratin 8	376	Necessary for interaction with PNN.|Rod.|Coil 2.				cytoskeleton organization|interspecies interaction between organisms	cytoplasm|keratin filament|nuclear matrix|nucleoplasm	protein binding|structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.108)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TTCATCAGCTCCTGGTACTCA	0.642		NaN											1	0	7.63091e-17	1	8.00164e-17	40	51									
ESPL1	9700	broad.mit.edu	37	12	53677939	53677939	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:53677939G>C	uc001sck.2	+	17	3266	c.3175G>C	c.(3175-3177)GAG>CAG	p.E1059Q	ESPL1_uc001scj.2_Missense_Mutation_p.E734Q|ESPL1_uc010soe.1_Missense_Mutation_p.E270Q	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	1059					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						GTTCTTGCTTGAGTCTTGCAC	0.527		NaN											0	0	0	1	0	32	52									
OR6C65	403282	broad.mit.edu	37	12	55794872	55794872	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:55794872G>C	uc010spl.1	+	1	560	c.560G>C	c.(559-561)TGC>TCC	p.C187S		NM_001005518	NP_001005518	A6NJZ3	O6C65_HUMAN	olfactory receptor, family 6, subfamily C,	187	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						CTGATTGCTTGCACAGACACA	0.448		NaN											0	0	0	1	0	74	105									
ANKRD52	283373	broad.mit.edu	37	12	56645860	56645860	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:56645860A>G	uc001skm.3	-	15	1621	c.1531T>C	c.(1531-1533)TCC>CCC	p.S511P		NM_173595	NP_775866	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	511	ANK 15.						protein binding			ovary(2)	2						TCATGGCTGGAAGGTGTATGG	0.592		NaN											0	0	0	1	0	5	35									
LEMD3	23592	broad.mit.edu	37	12	65563434	65563434	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:65563434C>G	uc001ssl.1	+	1	64	c.58C>G	c.(58-60)CAG>GAG	p.Q20E	LEMD3_uc009zqo.1_Missense_Mutation_p.Q20E	NM_014319	NP_055134	Q9Y2U8	MAN1_HUMAN	LEM domain containing 3	20	LEM.				negative regulation of activin receptor signaling pathway|negative regulation of BMP signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway	integral to nuclear inner membrane|membrane fraction	DNA binding|nucleotide binding|protein binding			central_nervous_system(3)|ovary(1)	4			LUAD - Lung adenocarcinoma(6;0.0234)|LUSC - Lung squamous cell carcinoma(43;0.0975)	GBM - Glioblastoma multiforme(28;0.0104)		GCTTTTCTCTCAGCTCCGCCG	0.602		NaN											0	0	0	1	0	2	4									
C12orf74	338809	broad.mit.edu	37	12	93100662	93100662	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:93100662G>A	uc001tch.1	+	2	485	c.255G>A	c.(253-255)TCG>TCA	p.S85S	C12orf74_uc001tci.2_Silent_p.S85S	NM_001037671	NP_001032760	Q32Q52	CL074_HUMAN	hypothetical protein LOC338809	85											0						GTTACCTTTCGAAGAGCCTGC	0.567		NaN											0	0	0	1	0	14	41									
ANKRD13A	88455	broad.mit.edu	37	12	110468561	110468561	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:110468561C>T	uc001tpx.2	+	12	1605	c.1346C>T	c.(1345-1347)TCA>TTA	p.S449L	ANKRD13A_uc009zvl.1_RNA|ANKRD13A_uc010sxw.1_Missense_Mutation_p.S448L|ANKRD13A_uc001tpy.2_Intron|ANKRD13A_uc001tpz.2_Missense_Mutation_p.S87L|ANKRD13A_uc001tqa.2_Missense_Mutation_p.S87L	NM_033121	NP_149112	Q8IZ07	AN13A_HUMAN	ankyrin repeat domain 13	449											0						CAGGCTGATTCAGGtaaaaaa	0.219		NaN											0	0	0	1	0	7	8									
CCDC63	160762	broad.mit.edu	37	12	111296402	111296402	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:111296402G>C	uc001trv.1	+	4	387	c.192G>C	c.(190-192)AAG>AAC	p.K64N	CCDC63_uc009zvt.1_5'UTR|CCDC63_uc010sye.1_Missense_Mutation_p.K24N|CCDC63_uc001trw.1_5'UTR	NM_152591	NP_689804	Q8NA47	CCD63_HUMAN	coiled-coil domain containing 63	64	Potential.									skin(6)|ovary(1)|pancreas(1)	8						AGGAGATCAAGACCCTGAAGA	0.502		NaN											0	0	0	1	0	7	19									
SBNO1	55206	broad.mit.edu	37	12	123789171	123789171	+	Silent	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:123789171G>C	uc010tap.1	-	28	3726	c.3726C>G	c.(3724-3726)CTC>CTG	p.L1242L	SBNO1_uc009zxv.2_RNA|SBNO1_uc010tao.1_Silent_p.L1241L|SBNO1_uc010taq.1_Silent_p.L193L|SBNO1_uc001ues.1_Silent_p.L193L	NM_018183	NP_060653	A3KN83	SBNO1_HUMAN	sno, strawberry notch homolog 1	1242							ATP binding|DNA binding|hydrolase activity			breast(5)|skin(2)|ovary(1)|kidney(1)	9	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000701)|Epithelial(86;0.00197)		TTTCTAATTTGAGCTGCTTCC	0.259		NaN											0	0	0	1	0	7	20									
GPR133	283383	broad.mit.edu	37	12	131471828	131471828	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:131471828G>A	uc001uit.3	+	6	1238	c.679G>A	c.(679-681)GAG>AAG	p.E227K	GPR133_uc010tbm.1_Missense_Mutation_p.E259K	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	227	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		TGCTTTCGATGAGTTCATCAT	0.542		NaN											0	0	0	1	0	14	44									
GOLGA3	2802	broad.mit.edu	37	12	133353621	133353621	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr12:133353621C>T	uc001ukz.1	-	20	4337	c.3778G>A	c.(3778-3780)GAG>AAG	p.E1260K	GOLGA3_uc001ula.1_Missense_Mutation_p.E1260K	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	1260	Potential.|Gln-rich.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		GCCCGGGCCTCGGCCAGCTCT	0.587		NaN											0	0	0	1	0	9	15									
IFT88	8100	broad.mit.edu	37	13	21217598	21217598	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:21217598G>A	uc001unh.2	+	21	2110	c.1714G>A	c.(1714-1716)GAA>AAA	p.E572K	IFT88_uc001uni.2_Missense_Mutation_p.E563K|IFT88_uc001unj.2_Missense_Mutation_p.E562K|IFT88_uc010tcq.1_Missense_Mutation_p.E543K	NM_175605	NP_783195	Q13099	IFT88_HUMAN	intraflagellar transport 88 homolog isoform 1	572	TPR 9.				cilium morphogenesis	centriole|intraflagellar transport particle B|microtubule basal body|microtubule-based flagellum	protein binding			ovary(1)	1		all_cancers(29;5.79e-25)|all_epithelial(30;2.57e-20)|all_lung(29;3.13e-16)|Lung SC(185;0.0262)|Ovarian(182;0.0825)|Hepatocellular(188;0.244)		all cancers(112;0.000667)|Epithelial(112;0.00119)|OV - Ovarian serous cystadenocarcinoma(117;0.0141)|Lung(94;0.0183)|LUSC - Lung squamous cell carcinoma(192;0.0528)		CATAAGATATGAATTAATGGA	0.318		NaN											0	0	0	1	0	11	42									
PARP4	143	broad.mit.edu	37	13	25016097	25016097	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:25016097C>G	uc001upl.2	-	30	3659	c.3553G>C	c.(3553-3555)GAG>CAG	p.E1185Q		NM_006437	NP_006428	Q9UKK3	PARP4_HUMAN	poly (ADP-ribose) polymerase family, member 4	1185					cell death|DNA repair|inflammatory response|protein ADP-ribosylation|response to drug|transport	cytoplasm|nucleus|ribonucleoprotein complex|spindle microtubule	DNA binding|enzyme binding|NAD+ ADP-ribosyltransferase activity			ovary(3)|skin(1)	4		all_epithelial(30;7.67e-16)|Lung SC(185;0.0225)|Breast(139;0.052)		all cancers(112;0.000127)|Epithelial(112;0.000778)|Kidney(163;0.039)|OV - Ovarian serous cystadenocarcinoma(117;0.0578)|KIRC - Kidney renal clear cell carcinoma(186;0.135)|Lung(94;0.195)		AAAGGCGACTCATTCTCATCC	0.403		NaN											0	0	0	1	0	11	42									
NUPL1	9818	broad.mit.edu	37	13	25876015	25876015	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:25876015C>T	uc001uqi.2	+	1	350	c.104C>T	c.(103-105)TCT>TTT	p.S35F	NUPL1_uc001uqg.1_Missense_Mutation_p.S35F|NUPL1_uc001uqj.2_Missense_Mutation_p.S35F	NM_014089	NP_054808	Q9BVL2	NUPL1_HUMAN	nucleoporin like 1 isoform a	35	14 X 2 AA repeats of F-G.				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore					0		Lung SC(185;0.0225)|Breast(139;0.0351)		all cancers(112;0.0092)|Epithelial(112;0.0477)|OV - Ovarian serous cystadenocarcinoma(117;0.165)|GBM - Glioblastoma multiforme(144;0.244)		ACGGGAGCGTCTAGGTAACCG	0.662		NaN											0	0	0	1	0	5	9									
LNX2	222484	broad.mit.edu	37	13	28127506	28127506	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:28127506C>T	uc001url.3	-	8	1926	c.1617G>A	c.(1615-1617)CTG>CTA	p.L539L	LNX2_uc001urm.1_Silent_p.L539L	NM_153371	NP_699202	Q8N448	LNX2_HUMAN	ligand of numb-protein X 2	539	PDZ 3.						zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)|central_nervous_system(1)	6		Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.113)|all cancers(112;0.127)|Epithelial(112;0.248)		CACTGGCTTTCAGCATTGCAA	0.478		NaN											0	0	0	1	0	15	52									
KATNAL1	84056	broad.mit.edu	37	13	30782761	30782761	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:30782761C>T	uc001uss.2	-	11	1490	c.1389G>A	c.(1387-1389)TTG>TTA	p.L463L	KATNAL1_uc001ust.2_Silent_p.L463L	NM_001014380	NP_001014402	Q9BW62	KATL1_HUMAN	katanin p60 subunit A-like 1	463						cytoplasm|microtubule	ATP binding|microtubule-severing ATPase activity				0		Lung SC(185;0.0257)		all cancers(112;0.114)|OV - Ovarian serous cystadenocarcinoma(117;0.213)		TCTTTAGGGCCAATTCAAAGT	0.418		NaN											0	0	0	1	0	24	55									
ZC3H13	23091	broad.mit.edu	37	13	46594682	46594682	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:46594682G>C	uc010tfw.1	-	4	356	c.350C>G	c.(349-351)TCA>TGA	p.S117*	ZC3H13_uc001vas.1_Nonsense_Mutation_p.S117*|ZC3H13_uc001vat.1_Nonsense_Mutation_p.S117*	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	117							nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		TCTCCCTCTTGAAGATTCTTT	0.284		NaN											0	0	0	1	0	11	33									
RB1	5925	broad.mit.edu	37	13	48936983	48936983	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:48936983C>T	uc001vcb.2	+	8	917	c.751C>T	c.(751-753)CGA>TGA	p.R251*	RB1_uc010acs.1_RNA|RB1_uc010act.1_Intron	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	251					androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(5)|p.R251*(3)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGGTTCACCTCGAACACCCAG	0.343		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			0	0	0	1	0	17	46									
SLITRK1	114798	broad.mit.edu	37	13	84454070	84454070	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:84454070C>G	uc001vlk.2	-	1	2459	c.1573G>C	c.(1573-1575)GAC>CAC	p.D525H		NM_052910	NP_443142	Q96PX8	SLIK1_HUMAN	slit and trk like 1 protein precursor	525	Extracellular (Potential).					integral to membrane				ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5	Medulloblastoma(90;0.18)	Breast(118;0.212)		GBM - Glioblastoma multiforme(99;0.07)		CCGTGGAGGTCTATCTGGATG	0.557		NaN											0	0	0	1	0	16	46									
GPC5	2262	broad.mit.edu	37	13	92345940	92345940	+	Silent	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:92345940C>G	uc010tif.1	+	3	1191	c.825C>G	c.(823-825)CTC>CTG	p.L275L		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	275						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				GATACTGCCTCAATGTCATGC	0.547		NaN											0	0	0	1	0	5	73									
STK24	8428	broad.mit.edu	37	13	99114081	99114081	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:99114081G>A	uc001vnm.1	-	8	1271	c.1036C>T	c.(1036-1038)CCC>TCC	p.P346S	STK24_uc001vnn.1_Missense_Mutation_p.P334S|STK24_uc010tim.1_Missense_Mutation_p.P315S	NM_003576	NP_003567	Q9Y6E0	STK24_HUMAN	serine/threonine kinase 24 isoform a	346					cellular component disassembly involved in apoptosis|signal transduction	cytosol|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(1)|lung(1)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			AGATTCTTGGGATCTTTTTCT	0.507		NaN											0	0	0	1	0	33	74									
FAM155A	728215	broad.mit.edu	37	13	108518877	108518877	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:108518877C>T	uc001vql.2	-	1	584	c.68G>A	c.(67-69)CGA>CAA	p.R23Q		NM_001080396	NP_001073865	B1AL88	F155A_HUMAN	family with sequence similarity 155, member A	23						integral to membrane	binding			skin(1)	1						CTCGTTCTCTCGGGGTGCTGC	0.532		NaN											0	0	0	1	0	55	133									
LIG4	3981	broad.mit.edu	37	13	108861843	108861843	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:108861843C>T	uc001vqn.2	-	2	2047	c.1774G>A	c.(1774-1776)GAG>AAG	p.E592K	LIG4_uc001vqo.2_Missense_Mutation_p.E592K|LIG4_uc010agg.1_Missense_Mutation_p.E525K|LIG4_uc010agf.2_Missense_Mutation_p.E592K|LIG4_uc001vqp.2_Missense_Mutation_p.E592K	NM_002312	NP_002303	P49917	DNLI4_HUMAN	DNA ligase IV	592					cell cycle|cell division|cell proliferation|central nervous system development|chromosome organization|DNA ligation involved in DNA recombination|DNA ligation involved in DNA repair|DNA replication|double-strand break repair via nonhomologous end joining|in utero embryonic development|initiation of viral infection|isotype switching|negative regulation of neuron apoptosis|neuron apoptosis|nucleotide-excision repair, DNA gap filling|positive regulation of fibroblast proliferation|positive regulation of neurogenesis|pro-B cell differentiation|provirus integration|response to gamma radiation|response to X-ray|single strand break repair|somatic stem cell maintenance|T cell differentiation in thymus|T cell receptor V(D)J recombination	condensed chromosome|cytoplasm|DNA ligase IV complex|DNA-dependent protein kinase-DNA ligase 4 complex|focal adhesion|nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding|protein C-terminus binding				0	all_lung(23;0.000238)|all_neural(89;0.00256)|Lung NSC(43;0.0056)|Medulloblastoma(90;0.00596)|Lung SC(71;0.104)					GTCATGCACTCATGCCACTCC	0.448		NaN						NHEJ					0	0	0	1	0	21	49									
TNFSF13B	10673	broad.mit.edu	37	13	108959240	108959240	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr13:108959240C>T	uc001vqr.2	+	6	1079	c.812C>T	c.(811-813)TCA>TTA	p.S271L	TNFSF13B_uc010agj.2_Missense_Mutation_p.S252L	NM_006573	NP_006564	Q9Y275	TN13B_HUMAN	tumor necrosis factor superfamily, member 13b	271	Extracellular (Potential).				cell proliferation|immune response|signal transduction	extracellular space|integral to membrane|plasma membrane|soluble fraction	cytokine activity|tumor necrosis factor receptor binding				0	all_lung(23;0.000396)|all_neural(89;0.00256)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00902)|Lung SC(71;0.104)		all cancers(43;0.184)|BRCA - Breast invasive adenocarcinoma(86;0.19)			GCACAAATATCACTGGATGGA	0.393		NaN											0	0	0	1	0	15	38									
NID2	22795	broad.mit.edu	37	14	52485839	52485839	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr14:52485839C>T	uc001wzo.2	-	14	3202	c.2968G>A	c.(2968-2970)GAA>AAA	p.E990K	NID2_uc010tqs.1_Missense_Mutation_p.E942K|NID2_uc010tqt.1_Missense_Mutation_p.E990K|NID2_uc001wzp.2_Missense_Mutation_p.E990K	NM_007361	NP_031387	Q14112	NID2_HUMAN	nidogen 2 precursor	990	Thyroglobulin type-1 1.					basement membrane	calcium ion binding|collagen binding			pancreas(2)|breast(2)|ovary(1)|liver(1)|skin(1)	7	Breast(41;0.0639)|all_epithelial(31;0.123)					CCAGGAACTTCATGACCATCA	0.602		NaN											0	0	0	1	0	8	22									
FUT8	2530	broad.mit.edu	37	14	66209049	66209049	+	Missense_Mutation	SNP	C	C	T	rs149328619	byFrequency	TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr14:66209049C>T	uc001xin.2	+	11	2846	c.1649C>T	c.(1648-1650)ACG>ATG	p.T550M	FUT8_uc001xio.2_Missense_Mutation_p.T550M|FUT8_uc010tsp.1_Missense_Mutation_p.T387M|FUT8_uc001xir.3_RNA|FUT8_uc001xip.2_Missense_Mutation_p.T550M|FUT8_uc001xiq.2_Missense_Mutation_p.T421M|FUT8_uc001xis.2_Missense_Mutation_p.T144M	NM_178155	NP_835368	Q9BYC5	FUT8_HUMAN	fucosyltransferase 8 isoform a	550	SH3.|Lumenal (Potential).				in utero embryonic development|L-fucose catabolic process|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in Golgi|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	glycoprotein 6-alpha-L-fucosyltransferase activity|SH3 domain binding			ovary(1)	1				all cancers(60;0.00109)|OV - Ovarian serous cystadenocarcinoma(108;0.00242)|BRCA - Breast invasive adenocarcinoma(234;0.0114)		TTGGGAAGGACGGGCCTATAT	0.443		NaN											0	0	0	1	0	15	79									
KIAA0317	9870	broad.mit.edu	37	14	75143291	75143291	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr14:75143291G>A	uc001xqb.2	-	6	1151	c.646C>T	c.(646-648)CAT>TAT	p.H216Y	KIAA0317_uc010tut.1_Missense_Mutation_p.H55Y|KIAA0317_uc001xqc.2_Missense_Mutation_p.H216Y	NM_001039479	NP_001034568	O15033	K0317_HUMAN	hypothetical protein LOC9870	216					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	integral to membrane|intracellular	ubiquitin-protein ligase activity			ovary(2)|kidney(1)|central_nervous_system(1)|pancreas(1)	5				BRCA - Breast invasive adenocarcinoma(234;0.00404)		CTTACCTCATGAATGGACAAG	0.453		NaN											0	0	0	1	0	23	113									
CCDC88C	440193	broad.mit.edu	37	14	91805717	91805717	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr14:91805717G>A	uc010aty.2	-	8	813	c.714C>T	c.(712-714)CCC>CCT	p.P238P	CCDC88C_uc010twk.1_Silent_p.P202P	NM_001080414	NP_001073883	Q9P219	DAPLE_HUMAN	DVL-binding protein DAPLE	238					microtubule cytoskeleton organization|protein destabilization|protein homooligomerization|regulation of protein phosphorylation|Wnt receptor signaling pathway	cytoplasm|insoluble fraction	microtubule binding|PDZ domain binding|protein self-association			ovary(3)	3		all_cancers(154;0.0468)				TGGTGGGGCTGGGAGTGGAGT	0.662		NaN											0	0	0	1	0	4	18									
TDRD9	122402	broad.mit.edu	37	14	104488586	104488586	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr14:104488586C>T	uc001yom.3	+	24	2555	c.2525C>T	c.(2524-2526)TCA>TTA	p.S842L	TDRD9_uc001yon.3_Missense_Mutation_p.S580L	NM_153046	NP_694591	Q8NDG6	TDRD9_HUMAN	tudor domain containing 9	842					cell differentiation|DNA methylation involved in gamete generation|fertilization|gene silencing by RNA|male meiosis|multicellular organismal development|piRNA metabolic process|spermatogenesis	nucleus|piP-body	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(2)|central_nervous_system(1)	3		all_cancers(154;0.109)|Melanoma(154;0.0525)|all_epithelial(191;0.0768)				CTAAAAGTTTCACTTGAACTC	0.428		NaN											0	0	0	1	0	6	16									
NIPA1	123606	broad.mit.edu	37	15	23049167	23049167	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:23049167G>A	uc001yvc.2	-	5	677	c.652C>T	c.(652-654)CAT>TAT	p.H218Y	NIPA1_uc001yvd.2_Missense_Mutation_p.H48Y|NIPA1_uc001yve.2_Missense_Mutation_p.H143Y	NM_144599	NP_653200	Q7RTP0	NIPA1_HUMAN	non-imprinted in Prader-Willi/Angelman syndrome	218	Extracellular (Potential).				cell death	early endosome|integral to membrane|plasma membrane					0		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;4.18e-06)|Epithelial(43;3.97e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00165)		GGGTTGTTATGCAAGATGTCT	0.587		NaN											0	0	0	1	0	18	43									
UBE3A	7337	broad.mit.edu	37	15	25616710	25616710	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:25616710G>C	uc001zaq.2	-	4	620	c.620C>G	c.(619-621)TCA>TGA	p.S207*	uc001zae.2_Intron|UBE3A_uc001zar.2_Nonsense_Mutation_p.S184*|UBE3A_uc001zas.2_Nonsense_Mutation_p.S204*|UBE3A_uc001zat.2_Nonsense_Mutation_p.S184*	NM_000462	NP_000453	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A isoform 2	207					brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)		AGATGCTTCTGAGTCTTCTTC	0.408		NaN											0	0	0	1	0	45	141									
TJP1	7082	broad.mit.edu	37	15	30064302	30064302	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:30064302G>A	uc001zcr.2	-	4	752	c.277C>T	c.(277-279)CAG>TAG	p.Q93*	TJP1_uc010azl.2_Nonsense_Mutation_p.Q81*|TJP1_uc001zcq.2_Nonsense_Mutation_p.Q97*|TJP1_uc001zcs.2_Nonsense_Mutation_p.Q93*	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	93	PDZ 1.				cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		CTTAGTTGCTGAACAGCAAAA	0.348		NaN											0	0	0	1	0	12	29									
RYR3	6263	broad.mit.edu	37	15	34064217	34064217	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:34064217G>A	uc001zhi.2	+	63	8983	c.8913G>A	c.(8911-8913)CTG>CTA	p.L2971L	RYR3_uc010bar.2_Silent_p.L2971L	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2971	Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		CAGAAAACCTGAAACTTGGGA	0.473		NaN											0	0	0	1	0	5	16									
CAPN3	825	broad.mit.edu	37	15	42703108	42703108	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:42703108G>C	uc001zpn.1	+	22	2596	c.2290G>C	c.(2290-2292)GAC>CAC	p.D764H	CAPN3_uc001zpk.1_Missense_Mutation_p.D531H|CAPN3_uc001zpl.1_Missense_Mutation_p.D671H|CAPN3_uc010udf.1_Missense_Mutation_p.D677H|CAPN3_uc010udg.1_Missense_Mutation_p.D629H|CAPN3_uc001zpo.1_Missense_Mutation_p.D758H|CAPN3_uc001zpp.1_Missense_Mutation_p.D672H|CAPN3_uc001zpq.1_Missense_Mutation_p.D252H|CAPN3_uc010bcv.1_Missense_Mutation_p.D99H|CAPN3_uc001zpr.1_Missense_Mutation_p.D99H|CAPN3_uc001zps.1_Missense_Mutation_p.D99H|CAPN3_uc001zpt.1_Missense_Mutation_p.D99H	NM_000070	NP_000061	P20807	CAN3_HUMAN	calpain 3 isoform a	764	Domain IV.				muscle organ development|proteolysis	cytoplasm	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity|signal transducer activity			central_nervous_system(1)	1		all_cancers(109;1.65e-16)|all_epithelial(112;8.34e-15)|Lung NSC(122;3.56e-09)|all_lung(180;1.68e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;7.36e-07)		CCAGCTCTATGACATCATTAC	0.517		NaN											0	0	0	1	0	20	49									
UBR1	197131	broad.mit.edu	37	15	43294862	43294862	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:43294862G>A	uc001zqq.2	-	32	3616	c.3550C>T	c.(3550-3552)CAT>TAT	p.H1184Y		NM_174916	NP_777576	Q8IWV7	UBR1_HUMAN	ubiquitin protein ligase E3 component n-recognin	1184	RING-type; atypical.				cellular response to leucine|negative regulation of TOR signaling cascade	cytosol	leucine binding|zinc ion binding			lung(1)	1		all_cancers(109;4.32e-15)|all_epithelial(112;4.05e-13)|Lung NSC(122;1.75e-08)|all_lung(180;2e-07)|Melanoma(134;0.0179)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;4.08e-07)|COAD - Colon adenocarcinoma(120;0.185)|Colorectal(105;0.214)		AGGTCAACATGAATGCGCTGC	0.413		NaN											0	0	0	1	0	13	44									
PLDN	26258	broad.mit.edu	37	15	45884353	45884353	+	Missense_Mutation	SNP	G	G	A	rs149605903		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:45884353G>A	uc001zvq.2	+	2	328	c.103G>A	c.(103-105)GAT>AAT	p.D35N	PLDN_uc001zvr.2_RNA|PLDN_uc001zvs.2_RNA	NM_012388	NP_036520	Q9UL45	PLDN_HUMAN	pallidin	35					post-Golgi vesicle-mediated transport|synaptic vesicle docking involved in exocytosis	BLOC-1 complex|endomembrane system|membrane	identical protein binding|syntaxin-13 binding			skin(1)	1		Lung NSC(122;1.6e-06)|all_lung(180;1.13e-05)|Melanoma(134;0.027)		all cancers(107;6.58e-18)|GBM - Glioblastoma multiforme(94;5.91e-07)		CACTTCTCCAGATGAAGGGTT	0.313		NaN											0	0	0	1	0	15	38									
CEP152	22995	broad.mit.edu	37	15	49048212	49048212	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:49048212G>A	uc001zwy.2	-	20	3267	c.3233C>T	c.(3232-3234)TCT>TTT	p.S1078F	CEP152_uc001zwz.2_Missense_Mutation_p.S1078F|CEP152_uc001zxa.1_Missense_Mutation_p.S985F	NM_014985	NP_055800	O94986	CE152_HUMAN	centrosomal protein 152kDa	1078					centrosome duplication|G2/M transition of mitotic cell cycle	centrosome|cytosol	protein kinase binding			lung(2)	2		all_lung(180;0.0428)		all cancers(107;1.08e-07)|GBM - Glioblastoma multiforme(94;2.32e-06)		CCATTTTGAAGAACAAGTCGA	0.408		NaN											0	0	0	1	0	41	99									
TLN2	83660	broad.mit.edu	37	15	63029226	63029226	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:63029226G>C	uc002alb.3	+	26	3508	c.3508G>C	c.(3508-3510)GAG>CAG	p.E1170Q		NM_015059	NP_055874	Q9Y4G6	TLN2_HUMAN	talin 2	1170	Ala-rich.				cell adhesion|cell-cell junction assembly|cytoskeletal anchoring at plasma membrane	actin cytoskeleton|cytoplasm|focal adhesion|ruffle|synapse	actin binding|insulin receptor binding|structural constituent of cytoskeleton			ovary(5)|upper_aerodigestive_tract(2)|lung(2)|breast(2)	11						GCTCATTCAAGAGGCCAAGCA	0.577		NaN											0	0	0	1	0	14	41									
DENND4A	10260	broad.mit.edu	37	15	65983618	65983618	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:65983618C>T	uc002aph.2	-	22	3560	c.3182G>A	c.(3181-3183)GGA>GAA	p.G1061E	DENND4A_uc002api.2_Missense_Mutation_p.G1104E|DENND4A_uc002apj.3_Missense_Mutation_p.G1061E	NM_005848	NP_005839	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A isoform 2	1061					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						TGCATCAGCTCCCAATTTTTC	0.378		NaN											0	0	0	1	0	5	31									
KIF23	9493	broad.mit.edu	37	15	69721528	69721528	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:69721528G>A	uc002asb.2	+	10	1165	c.1048G>A	c.(1048-1050)GAA>AAA	p.E350K	KIF23_uc002asc.2_Missense_Mutation_p.E350K|KIF23_uc010bii.2_Missense_Mutation_p.E240K|KIF23_uc010ukc.1_Missense_Mutation_p.E167K|KIF23_uc010bih.1_RNA	NM_138555	NP_612565	Q02241	KIF23_HUMAN	kinesin family member 23 isoform 1	350	Kinesin-motor.				blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding				0						GACCAGAGCAGAAGGGAACAG	0.368		NaN											0	0	0	1	0	13	16									
KIF23	9493	broad.mit.edu	37	15	69737198	69737198	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:69737198G>A	uc002asb.2	+	19	2566	c.2449G>A	c.(2449-2451)GAC>AAC	p.D817N	KIF23_uc002asc.2_Missense_Mutation_p.D713N|KIF23_uc010bii.2_Intron|KIF23_uc010ukc.1_Missense_Mutation_p.D530N	NM_138555	NP_612565	Q02241	KIF23_HUMAN	kinesin family member 23 isoform 1	817					blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding				0						CTCTGCAGGAGACAGATGGGT	0.453		NaN											0	0	0	1	0	10	65									
BBS4	585	broad.mit.edu	37	15	73004593	73004593	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:73004593C>G	uc002avb.2	+	4	208	c.165C>G	c.(163-165)ATC>ATG	p.I55M	BBS4_uc010ukv.1_Missense_Mutation_p.I43M|BBS4_uc002avc.2_Translation_Start_Site|BBS4_uc002avd.2_Missense_Mutation_p.I63M	NM_033028	NP_149017	Q96RK4	BBS4_HUMAN	Bardet-Biedl syndrome 4	55	Required for localization to centrosomes.				adult behavior|brain morphogenesis|cell cycle cytokinesis|centrosome organization|cerebral cortex development|convergent extension involved in gastrulation|dendrite development|fat cell differentiation|heart looping|hippocampus development|intracellular transport|maintenance of protein location in nucleus|melanosome transport|microtubule anchoring at centrosome|neural tube closure|nonmotile primary cilium assembly|photoreceptor cell maintenance|pigment granule aggregation in cell center|positive regulation of flagellum assembly|regulation of cilium beat frequency involved in ciliary motility|regulation of cytokinesis|regulation of lipid metabolic process|retina homeostasis|retinal rod cell development|sensory perception of smell|sensory processing|spermatid development|striatum development	BBSome|centriolar satellite|centriole|cilium membrane|microtubule basal body|motile cilium|nonmotile primary cilium|nucleus|pericentriolar material	alpha-tubulin binding|beta-tubulin binding|dynactin binding|microtubule motor activity				0						AGGCTGTTATCAAAGAACAGC	0.358		NaN							Bardet-Biedl_syndrome				0	0	0	1	0	6	25									
C15orf42	90381	broad.mit.edu	37	15	90119340	90119340	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr15:90119340G>A	uc002boe.2	+	1	523	c.523G>A	c.(523-525)GAG>AAG	p.E175K		NM_152259	NP_689472	Q7Z2Z1	TICRR_HUMAN	leucine-rich repeat kinase 1	175					cell cycle|DNA repair|DNA replication|formation of translation preinitiation complex|G2/M transition checkpoint|mitotic cell cycle DNA replication checkpoint|regulation of DNA-dependent DNA replication initiation|response to ionizing radiation	nucleus	chromatin binding|protein binding			ovary(4)|central_nervous_system(2)|skin(1)	7	Lung NSC(78;0.0237)|all_lung(78;0.0478)		BRCA - Breast invasive adenocarcinoma(143;0.128)			GTCTGGGTGCGAGGCCCAGGC	0.662		NaN											0	0	0	1	0	6	19									
FLYWCH1	84256	broad.mit.edu	37	16	2983500	2983500	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr16:2983500G>A	uc002csd.2	+	5	1529	c.1166G>A	c.(1165-1167)AGA>AAA	p.R389K	FLYWCH1_uc002csb.2_Missense_Mutation_p.R388K|FLYWCH1_uc002csc.2_Missense_Mutation_p.R388K|FLYWCH1_uc010bsv.2_Missense_Mutation_p.R64K	NM_032296	NP_115672	Q4VC44	FWCH1_HUMAN	FLYWCH-type zinc finger 1 isoform a	389						nucleus	DNA binding|metal ion binding				0						CCTCGGCCCAGAAAGCGAGCA	0.657		NaN											0	0	0	1	0	5	8									
POLR3E	55718	broad.mit.edu	37	16	22319516	22319516	+	Silent	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr16:22319516C>G	uc002dkk.2	+	4	291	c.135C>G	c.(133-135)CTC>CTG	p.L45L	POLR3E_uc002dkj.1_Silent_p.L45L|POLR3E_uc002dkm.2_Silent_p.L9L|POLR3E_uc010vbr.1_Silent_p.L45L|POLR3E_uc002dkl.2_Silent_p.L45L|POLR3E_uc010vbs.1_Intron|POLR3E_uc010vbt.1_Missense_Mutation_p.S6C	NM_018119	NP_060589	Q9NVU0	RPC5_HUMAN	RNA polymerase III polypeptide E	45					innate immune response|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA-directed RNA polymerase activity			ovary(1)|central_nervous_system(1)	2				GBM - Glioblastoma multiforme(48;0.012)		TTCCGCACCTCTCAGCCAAGA	0.627		NaN											0	0	0	1	0	10	43									
ERN2	10595	broad.mit.edu	37	16	23713758	23713758	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr16:23713758C>G	uc002dma.3	-	10	1347	c.1178G>C	c.(1177-1179)AGA>ACA	p.R393T	ERN2_uc010bxp.2_Missense_Mutation_p.R393T|ERN2_uc010bxq.1_Missense_Mutation_p.R201T	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	345	Lumenal (Potential).				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		TGAGGGGTATCTAACAGCAGT	0.582		NaN											0	0	0	1	0	52	124									
ITGAL	3683	broad.mit.edu	37	16	30506048	30506048	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr16:30506048C>T	uc002dyi.3	+	13	1556	c.1380C>T	c.(1378-1380)TTC>TTT	p.F460F	ITGAL_uc002dyj.3_Silent_p.F377F|ITGAL_uc010vev.1_Intron	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	460	FG-GAP 5.|Extracellular (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	GCTCTTATTTCGGTGGGGAGC	0.423		NaN											0	0	0	1	0	12	27									
PHKG2	5261	broad.mit.edu	37	16	30767535	30767535	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr16:30767535G>C	uc002dzk.1	+	7	682	c.589G>C	c.(589-591)GAG>CAG	p.E197Q	PHKG2_uc002dzi.1_Missense_Mutation_p.E197Q|PHKG2_uc002dzj.1_Missense_Mutation_p.E95Q	NM_000294	NP_000285	P15735	PHKG2_HUMAN	phosphorylase kinase, gamma 2 (testis)	197	Protein kinase.				glucose metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	ATP binding|calmodulin binding|phosphorylase kinase activity			ovary(1)	1			Colorectal(24;0.198)			TCTAGCGCCAGAGATCCTTAA	0.587		NaN											0	0	0	1	0	36	115									
CHST6	4166	broad.mit.edu	37	16	75513367	75513367	+	Silent	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr16:75513367G>C	uc002fef.2	-	3	540	c.360C>G	c.(358-360)CTC>CTG	p.L120L	CHST6_uc002feg.1_RNA|CHST6_uc002feh.1_Silent_p.L120L	NM_021615	NP_067628	Q9GZX3	CHST6_HUMAN	carbohydrate (N-acetylglucosamine 6-O)	120	Lumenal (Potential).				keratan sulfate biosynthetic process|N-acetylglucosamine metabolic process	Golgi membrane|integral to membrane	N-acetylglucosamine 6-O-sulfotransferase activity				0						CCCACTGGAAGAGGTCGGACA	0.662		NaN											0	0	0	1	0	23	31									
ADAMTS18	170692	broad.mit.edu	37	16	77375607	77375607	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr16:77375607C>G	uc002ffc.3	-	11	2123	c.1704G>C	c.(1702-1704)TTG>TTC	p.L568F	ADAMTS18_uc010chc.1_Missense_Mutation_p.L156F|ADAMTS18_uc002ffe.1_Missense_Mutation_p.L264F	NM_199355	NP_955387	Q8TE60	ATS18_HUMAN	ADAM metallopeptidase with thrombospondin type 1	568	Disintegrin.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(4)|lung(4)|kidney(4)|skin(3)|breast(1)|ovary(1)|pancreas(1)	18						TTACCATACTCAAGCCACAAA	0.418		NaN											0	0	0	1	0	6	17									
RPA1	6117	broad.mit.edu	37	17	1747276	1747276	+	Silent	SNP	A	A	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:1747276A>T	uc002fto.2	+	3	262	c.147A>T	c.(145-147)GGA>GGT	p.G49G		NM_002945	NP_002936	P27694	RFA1_HUMAN	replication protein A1	49					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	actin cytoskeleton|cytoplasm|DNA replication factor A complex|PML body	metal ion binding|protein binding|single-stranded DNA binding				0						TGAGTGATGGATTGAACACTC	0.443		NaN						NER					0	0	0	1	0	10	43									
RPA1	6117	broad.mit.edu	37	17	1780584	1780584	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:1780584C>T	uc002fto.2	+	8	781	c.666C>T	c.(664-666)TTC>TTT	p.F222F		NM_002945	NP_002936	P27694	RFA1_HUMAN	replication protein A1	222					cell cycle checkpoint|DNA recombinase assembly|DNA strand elongation involved in DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	actin cytoskeleton|cytoplasm|DNA replication factor A complex|PML body	metal ion binding|protein binding|single-stranded DNA binding				0						GGAAGCTTTTCTCCCTAGAAC	0.532		NaN						NER					0	0	0	1	0	7	22									
RAP1GAP2	23108	broad.mit.edu	37	17	2861064	2861064	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:2861064C>G	uc010ckd.2	+	4	267	c.177C>G	c.(175-177)TTC>TTG	p.F59L	RAP1GAP2_uc010cke.2_Missense_Mutation_p.F59L	NM_015085	NP_055900	Q684P5	RPGP2_HUMAN	RAP1 GTPase activating protein 2 isoform 1	59					regulation of small GTPase mediated signal transduction	centrosome|cytosol|perinuclear region of cytoplasm	GTPase activator activity			ovary(1)	1						CGTCGGAGTTCTTTGAGATGC	0.567		NaN											0	0	0	1	0	26	57									
XAF1	54739	broad.mit.edu	37	17	6663026	6663026	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:6663026G>C	uc002gdn.2	+	3	456	c.214G>C	c.(214-216)GAG>CAG	p.E72Q	XAF1_uc010clr.1_Missense_Mutation_p.E72Q|XAF1_uc002gdm.1_Missense_Mutation_p.E12Q|XAF1_uc002gdo.2_Intron|XAF1_uc002gdp.2_Missense_Mutation_p.W49C|XAF1_uc002gdq.2_Intron|XAF1_uc002gdr.2_Intron	NM_017523	NP_059993	Q6GPH4	XAF1_HUMAN	XIAP associated factor 1 isoform 1	72	TRAF-type.				apoptosis|type I interferon-mediated signaling pathway	mitochondrion|nucleus	zinc ion binding				0						GTCCTCGCTGGAGTTTCATAA	0.438		NaN											0	0	0	1	0	12	48									
ZBTB4	57659	broad.mit.edu	37	17	7369149	7369149	+	Silent	SNP	C	C	G	rs143028324		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:7369149C>G	uc002ghc.3	-	3	1222	c.972G>C	c.(970-972)CTG>CTC	p.L324L	ZBTB4_uc002ghd.3_Silent_p.L324L	NM_001128833	NP_001122305	Q9P1Z0	ZBTB4_HUMAN	zinc finger and BTB domain containing 4	324	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|central_nervous_system(1)	4		Colorectal(1115;3.46e-05)|Myeloproliferative disorder(207;0.0255)		COAD - Colon adenocarcinoma(228;4.1e-06)|READ - Rectum adenocarcinoma(115;0.0642)		TGTGTCTCTTCAGACTGGACA	0.607		NaN											0	0	0	1	0	18	33									
TP53	7157	broad.mit.edu	37	17	7577511	7577511	+	Missense_Mutation	SNP	A	A	T	rs28934577		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08			A	T	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:7577511A>T	uc002gim.2	-	7	964	c.770T>A	c.(769-771)CTG>CAG	p.L257Q	TP53_uc002gig.1_Missense_Mutation_p.L257Q|TP53_uc002gih.2_Missense_Mutation_p.L257Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.L125Q|TP53_uc010cng.1_Missense_Mutation_p.L125Q|TP53_uc002gii.1_Missense_Mutation_p.L125Q|TP53_uc010cnh.1_Missense_Mutation_p.L257Q|TP53_uc010cni.1_Missense_Mutation_p.L257Q|TP53_uc002gij.2_Missense_Mutation_p.L257Q|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.L164Q|TP53_uc002gio.2_Missense_Mutation_p.L125Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	257	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		L -> R (in sporadic cancers; somatic mutation).|L -> V (in sporadic cancers; somatic mutation).|L -> P (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.L257P(8)|p.0?(7)|p.L257Q(7)|p.L257V(4)|p.L257L(2)|p.L257fs*6(2)|p.L257fs*88(1)|p.?(1)|p.L257fs*7(1)|p.T256fs*87(1)|p.L257R(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGAGTCTTCCAGTGTGATGAT	0.582		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	1	0	7	26									
TP53	7157	broad.mit.edu	37	17	7579529	7579529	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:7579529C>T	uc002gim.2	-	4	352	c.158G>A	c.(157-159)TGG>TAG	p.W53*	TP53_uc002gig.1_Nonsense_Mutation_p.W53*|TP53_uc002gih.2_Nonsense_Mutation_p.W53*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Nonsense_Mutation_p.W53*|TP53_uc010cni.1_Nonsense_Mutation_p.W53*|TP53_uc002gij.2_Nonsense_Mutation_p.W53*|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Nonsense_Mutation_p.W14*|TP53_uc010cnk.1_Nonsense_Mutation_p.W68*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	53	TADII.|Interaction with HRMT1L2.		W -> C (in sporadic cancers; somatic mutation).|W -> G (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.W53*(10)|p.0?(7)|p.W53C(2)|p.E51fs*59(1)|p.D48fs*55(1)|p.Q52fs*67(1)|p.W53fs*1(1)|p.P13fs*18(1)|p.S33fs*23(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCAGTGAACCATTGTTCAAT	0.592		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	1	0	49	128									
MYH1	4619	broad.mit.edu	37	17	10419630	10419630	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:10419630G>A	uc002gmo.2	-	4	328	c.234C>T	c.(232-234)TTC>TTT	p.F78F	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	78	Myosin head-like.					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						GGTTCATGGGGAAGACTTGGT	0.468		NaN											0	0	0	1	0	16	129									
SLC46A1	113235	broad.mit.edu	37	17	26731743	26731743	+	Silent	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:26731743G>C	uc002hbf.1	-	2	1068	c.972C>G	c.(970-972)CTC>CTG	p.L324L	SLC46A1_uc002hbg.1_Silent_p.L324L|SLC46A1_uc010wak.1_Silent_p.L324L	NM_080669	NP_542400	Q96NT5	PCFT_HUMAN	proton-coupled folate transporter	324	Helical; (Potential).				cellular iron ion homeostasis|folic acid metabolic process	apical plasma membrane|cytoplasm|integral to membrane	folic acid binding|folic acid transporter activity|heme transporter activity				0	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)	Folic Acid(DB00158)	AGTACTGCAGGAGCTTCAGGG	0.577		NaN											0	0	0	1	0	13	31									
SLC46A1	113235	broad.mit.edu	37	17	26732064	26732064	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:26732064G>A	uc002hbf.1	-	2	747	c.651C>T	c.(649-651)GCC>GCT	p.A217A	SLC46A1_uc002hbg.1_Silent_p.A217A|SLC46A1_uc010wak.1_Silent_p.A217A	NM_080669	NP_542400	Q96NT5	PCFT_HUMAN	proton-coupled folate transporter	217	Helical; (Potential).				cellular iron ion homeostasis|folic acid metabolic process	apical plasma membrane|cytoplasm|integral to membrane	folic acid binding|folic acid transporter activity|heme transporter activity				0	all_lung(13;0.000533)|Lung NSC(42;0.00171)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)	Folic Acid(DB00158)	CTATCAGCAAGGCCAAGGCCA	0.607		NaN											0	0	0	1	0	16	62									
C17orf42	79736	broad.mit.edu	37	17	29226414	29226414	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:29226414C>T	uc002hfu.2	-	4	926	c.856G>A	c.(856-858)GAA>AAA	p.E286K	C17orf42_uc002hfv.2_RNA	NM_024683	NP_078959	Q96QE5	TEFM_HUMAN	hypothetical protein LOC79736	286					oxidative phosphorylation|regulation of transcription, DNA-dependent|transcription from mitochondrial promoter	mitochondrial nucleoid|ribonucleoprotein complex	DNA polymerase processivity factor activity|nucleic acid binding|protein binding			ovary(1)	1		all_cancers(10;4.64e-07)|all_hematologic(16;0.014)|Acute lymphoblastic leukemia(14;0.0236)|Myeloproliferative disorder(56;0.0255)				ATCATCAGTTCAAAATGCTTC	0.468		NaN											0	0	0	1	0	34	69									
TMEM132E	124842	broad.mit.edu	37	17	32959762	32959762	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:32959762G>C	uc002hif.2	+	7	1580	c.1252G>C	c.(1252-1254)GAG>CAG	p.E418Q		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	418	Extracellular (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		GAGTGGAAAAGAGTCTCGAGG	0.567		NaN											0	0	0	1	0	18	53									
NLE1	54475	broad.mit.edu	37	17	33463472	33463472	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:33463472G>A	uc002hiy.1	-	8	901	c.873C>T	c.(871-873)AAC>AAT	p.N291N	NLE1_uc010ctn.1_5'UTR|NLE1_uc002hiz.1_5'UTR	NM_018096	NP_060566	Q9NVX2	NLE1_HUMAN	Notchless gene homolog isoform a	291						nucleolus				breast(3)|ovary(1)	4		Ovarian(249;0.17)				GGGCCATGGTGTTCACCCAGT	0.607		NaN											0	0	0	1	0	30	119									
KRT15	3866	broad.mit.edu	37	17	39671846	39671846	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:39671846C>T	uc002hwy.2	-	6	1316	c.1125G>A	c.(1123-1125)CTG>CTA	p.L375L	KRT15_uc002hwz.2_Silent_p.L277L|KRT15_uc002hxa.2_Silent_p.L210L|KRT15_uc002hxb.1_Silent_p.L210L	NM_002275	NP_002266	P19012	K1C15_HUMAN	keratin 15	375	Rod.|Coil 2.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000286)				GGAGCTCACTCAGCTGGGCCT	0.592		NaN											0	0	0	1	0	29	56									
KRT15	3866	broad.mit.edu	37	17	39673157	39673157	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:39673157C>T	uc002hwy.2	-	3	832	c.641G>A	c.(640-642)CGA>CAA	p.R214Q	KRT15_uc002hwz.2_Missense_Mutation_p.R116Q|KRT15_uc002hxa.2_Missense_Mutation_p.R49Q|KRT15_uc002hxb.1_Missense_Mutation_p.R49Q	NM_002275	NP_002266	P19012	K1C15_HUMAN	keratin 15	214	Rod.|Coil 1B.				epidermis development	intermediate filament	protein binding|structural constituent of cytoskeleton				0		Breast(137;0.000286)				ATCCAGGACTCGGCGCAAGCC	0.592		NaN											0	0	0	1	0	31	60									
MLX	6945	broad.mit.edu	37	17	40723603	40723603	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:40723603G>A	uc002iag.2	+	8	944	c.879G>A	c.(877-879)TTG>TTA	p.L293L	MLX_uc002iaf.2_Silent_p.L239L|MLX_uc002iah.2_Silent_p.L209L	NM_170607	NP_733752	Q9UH92	MLX_HUMAN	transcription factor-like protein 4 isoform	293					energy reserve metabolic process|negative regulation of transcription, DNA-dependent|positive regulation of cellular metabolic process	cytoplasm|nucleus	DNA binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding				0		all_cancers(22;4.26e-05)|Breast(137;0.000153)|all_epithelial(22;0.00148)		BRCA - Breast invasive adenocarcinoma(366;0.129)		TGCACCAATTGAAAAACCAGC	0.537		NaN											0	0	0	1	0	52	122									
WNK4	65266	broad.mit.edu	37	17	40933043	40933043	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:40933043G>A	uc002ibj.2	+	1	348	c.327G>A	c.(325-327)ACG>ACA	p.T109T	WNK4_uc010wgx.1_Translation_Start_Site|WNK4_uc002ibk.1_5'Flank	NM_032387	NP_115763	Q96J92	WNK4_HUMAN	WNK lysine deficient protein kinase 4	109					intracellular protein kinase cascade	tight junction	ATP binding|protein serine/threonine kinase activity			ovary(3)|skin(3)|stomach(1)	7		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.0749)		CCGAGGGCACGTGGACCGAGG	0.731		NaN											0	0	0	1	0	5	17									
CACNA1G	8913	broad.mit.edu	37	17	48696036	48696036	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:48696036C>T	uc002irk.1	+	33	5820	c.5448C>T	c.(5446-5448)GAC>GAT	p.D1816D	CACNA1G_uc002irj.1_Silent_p.D1782D|CACNA1G_uc002irl.1_Silent_p.D1793D|CACNA1G_uc002irm.1_Silent_p.D1782D|CACNA1G_uc002irn.1_Silent_p.D1775D|CACNA1G_uc002iro.1_Silent_p.D1782D|CACNA1G_uc002irp.1_Silent_p.D1816D|CACNA1G_uc002irq.1_Silent_p.D1793D|CACNA1G_uc002irr.1_Silent_p.D1816D|CACNA1G_uc002irs.1_Silent_p.D1805D|CACNA1G_uc002irt.1_Silent_p.D1798D|CACNA1G_uc002irv.1_Silent_p.D1805D|CACNA1G_uc002irw.1_Silent_p.D1793D|CACNA1G_uc002iru.1_Silent_p.D1782D|CACNA1G_uc002irx.1_Silent_p.D1729D|CACNA1G_uc002iry.1_Silent_p.D1718D|CACNA1G_uc002irz.1_Silent_p.D1722D|CACNA1G_uc002isa.1_Silent_p.D1695D|CACNA1G_uc002isb.1_Silent_p.D1736D|CACNA1G_uc002isc.1_Silent_p.D1718D|CACNA1G_uc002isd.1_Silent_p.D1704D|CACNA1G_uc002ise.1_Silent_p.D1684D|CACNA1G_uc002isf.1_Silent_p.D1711D|CACNA1G_uc002isg.1_Silent_p.D1677D|CACNA1G_uc002ish.1_Silent_p.D1684D|CACNA1G_uc002isi.1_Silent_p.D1672D	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	1816	IV.|Extracellular (Potential).				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GGGACTGTGACCAGGAGTCCA	0.577		NaN											0	0	0	1	0	4	27									
OR4D1	26689	broad.mit.edu	37	17	56233150	56233150	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:56233150C>T	uc010wno.1	+	1	636	c.636C>T	c.(634-636)CTC>CTT	p.L212L	MSX2P1_uc002ivn.2_5'Flank	NM_012374	NP_036506	Q15615	OR4D1_HUMAN	olfactory receptor, family 4, subfamily D,	212	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TCTGGTTCCTCCTCCTTCTGA	0.532		NaN											0	0	0	1	0	24	53									
CYB561	1534	broad.mit.edu	37	17	61514723	61514723	+	Silent	SNP	G	G	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:61514723G>T	uc002jap.2	-	1	588	c.186C>A	c.(184-186)ATC>ATA	p.I62I	CYB561_uc002jaq.2_Silent_p.I108I|CYB561_uc002jar.2_Silent_p.I62I|CYB561_uc002jas.2_Silent_p.I62I|CYB561_uc010ddt.2_Silent_p.I62I|CYB561_uc002jat.2_Silent_p.I62I|CYB561_uc010wpf.1_Silent_p.I62I|CYB561_uc010wpg.1_Silent_p.I33I	NM_001915	NP_001906	P49447	CY561_HUMAN	cytochrome b-561	62	Helical; (Potential).|Cytochrome b561.				electron transport chain|transport	integral to plasma membrane	cytochrome-b5 reductase activity|ferric-chelate reductase activity|metal ion binding			ovary(1)	1				READ - Rectum adenocarcinoma(1115;0.0689)		CCTGCAGGAAGATCAGGCCTA	0.647		NaN											1	0	6.31663e-08	1	6.54403e-08	16	47									
LRRC37A3	374819	broad.mit.edu	37	17	62864606	62864606	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:62864606G>A	uc002jey.2	-	9	3558	c.3027C>T	c.(3025-3027)CTC>CTT	p.L1009L	LRRC37A3_uc010wqg.1_Silent_p.L127L|LRRC37A3_uc010wqf.1_Silent_p.L47L|LRRC37A3_uc010dek.1_Silent_p.L15L	NM_199340	NP_955372	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	1009	Extracellular (Potential).|LRR 9.					integral to membrane					0						CAGTCATCATGAGAATGTTCT	0.313		NaN											0	0	0	1	0	40	105									
LRRC37A3	374819	broad.mit.edu	37	17	62865241	62865241	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:62865241G>C	uc002jey.2	-	8	3481	c.2950C>G	c.(2950-2952)CTC>GTC	p.L984V	LRRC37A3_uc010wqg.1_Missense_Mutation_p.L102V|LRRC37A3_uc010wqf.1_Missense_Mutation_p.L22V|LRRC37A3_uc010dek.1_Translation_Start_Site	NM_199340	NP_955372	O60309	L37A3_HUMAN	leucine rich repeat containing 37, member A3	984	Extracellular (Potential).|LRR 8.					integral to membrane					0						AATTTAAAGAGATATGGATCT	0.299		NaN											0	0	0	1	0	40	126									
ABCA10	10349	broad.mit.edu	37	17	67145021	67145021	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:67145021C>T	uc010dfa.1	-	40	5458	c.4579G>A	c.(4579-4581)GAT>AAT	p.D1527N	ABCA10_uc002jhz.2_RNA|ABCA10_uc010wqs.1_Missense_Mutation_p.D519N|ABCA10_uc010wqt.1_RNA	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	1527					transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					TCAATTTTATCATCAACATTT	0.348		NaN											0	0	0	1	0	18	71									
MRPL38	64978	broad.mit.edu	37	17	73895341	73895341	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:73895341C>G	uc010wso.1	-	8	1129	c.904G>C	c.(904-906)GAT>CAT	p.D302H	FBF1_uc002jqa.1_RNA|TRIM65_uc002jpx.2_5'Flank|MRPL38_uc002jpz.1_RNA	NM_032478	NP_115867	Q96DV4	RM38_HUMAN	mitochondrial ribosomal protein L38 precursor	302						actin cytoskeleton|mitochondrion|ribosome				pancreas(1)	1			all cancers(21;0.000154)|Epithelial(20;0.000156)|BRCA - Breast invasive adenocarcinoma(9;0.00936)|LUSC - Lung squamous cell carcinoma(166;0.154)			TTGTAGAAATCAAAAGTGCGG	0.557		NaN											0	0	0	1	0	5	14									
RNF213	57674	broad.mit.edu	37	17	78314035	78314035	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:78314035C>T	uc002jyh.1	+	1	310	c.87C>T	c.(85-87)CTC>CTT	p.L29L		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			AGGCACCCCTCGAGGCCATCC	0.632		NaN											0	0	0	1	0	11	33									
HGS	9146	broad.mit.edu	37	17	79667810	79667810	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:79667810C>T	uc002kbg.2	+	20	2179	c.2102C>T	c.(2101-2103)TCA>TTA	p.S701L	MRPL12_uc002kbh.1_5'Flank|SLC25A10_uc010wut.1_5'Flank	NM_004712	NP_004703	O14964	HGS_HUMAN	hepatocyte growth factor-regulated tyrosine	701	Interaction with NF2.|Gln-rich.				cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of cell proliferation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of JAK-STAT cascade|regulation of protein catabolic process	cytosol|early endosome membrane|multivesicular body membrane	metal ion binding|protein domain specific binding			ovary(1)	1	all_neural(118;0.0878)|all_lung(278;0.23)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0955)			GGGAGCCAGTCAGTCTCCATG	0.637		NaN											0	0	0	1	0	13	35									
CSNK1D	1453	broad.mit.edu	37	17	80223668	80223668	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:80223668C>T	uc002kej.2	-	2	397	c.81G>A	c.(79-81)ACG>ACA	p.T27T	CSNK1D_uc002kef.2_Silent_p.T27T|CSNK1D_uc002kei.2_Silent_p.T27T|CSNK1D_uc010wvj.1_5'UTR	NM_001893	NP_001884	P48730	KC1D_HUMAN	casein kinase 1, delta isoform 1	27	Protein kinase.				circadian regulation of gene expression|DNA repair|G2/M transition of mitotic cell cycle|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|regulation of circadian rhythm|Wnt receptor signaling pathway	centrosome|cytosol|nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			breast(2)	2	Breast(20;0.00136)|all_neural(118;0.0804)|Lung NSC(278;0.128)|all_lung(278;0.145)|Ovarian(332;0.227)		OV - Ovarian serous cystadenocarcinoma(97;0.00463)|BRCA - Breast invasive adenocarcinoma(99;0.0155)			CAGCAATGTCCGTACCTTGGC	0.438		NaN											0	0	0	1	0	37	76									
C17orf101	79701	broad.mit.edu	37	17	80373478	80373478	+	Missense_Mutation	SNP	C	C	T	rs116051835	by1000genomes	TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:80373478C>T	uc002keu.1	-	2	201	c.100G>A	c.(100-102)GAG>AAG	p.E34K	C17orf101_uc002ket.1_Missense_Mutation_p.E34K|C17orf101_uc010dip.1_RNA|HEXDC_uc002kev.3_5'Flank|HEXDC_uc010diq.2_5'Flank	NM_024648	NP_078924	Q6PK18	CQ101_HUMAN	hypothetical protein LOC79701 isoform 1	34	Cytoplasmic (Potential).					integral to membrane	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			ovary(1)	1						CTCTGCACCTCCCGCGGGGCT	0.637		NaN											0	0	0	1	0	14	23									
FOXK2	3607	broad.mit.edu	37	17	80477922	80477922	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr17:80477922C>T	uc002kfn.2	+	1	329	c.158C>T	c.(157-159)TCG>TTG	p.S53L	FOXK2_uc002kfm.1_Missense_Mutation_p.S53L|FOXK2_uc010diu.2_Missense_Mutation_p.S53L	NM_004514	NP_004505	Q01167	FOXK2_HUMAN	forkhead box K2	53	Gly-rich.			AAAAALSGAGTPPAGGGAGGGGAGGGGSPPGGWAVARLEGR EFEYLMKKRSVTIGRNSSQGSVDVSMGHSSFISRRHLEIFT PPGGGGHGGAAPELPPAQPRPDAGGDFYLRCLGKNG -> Q (in Ref. 1; CAA43200).	embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0	Breast(20;0.00106)|all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.0371)|BRCA - Breast invasive adenocarcinoma(99;0.0415)			AAGAAGCGCTCGGTGACCATC	0.557		NaN											0	0	0	1	0	13	22									
CLUL1	27098	broad.mit.edu	37	18	627295	627295	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr18:627295G>C	uc002kkp.2	+	5	767	c.622G>C	c.(622-624)GAG>CAG	p.E208Q	CLUL1_uc010wys.1_Missense_Mutation_p.E260Q|CLUL1_uc002kkq.2_Missense_Mutation_p.E208Q	NM_014410	NP_055225	Q15846	CLUL1_HUMAN	clusterin-like 1 (retinal) precursor	208					cell death	extracellular region				ovary(2)	2						GATGCAGCAAGAGTTTGACCA	0.408		NaN											0	0	0	1	0	52	147									
LAMA1	284217	broad.mit.edu	37	18	6966276	6966276	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr18:6966276G>A	uc002knm.2	-	49	7014	c.6920C>T	c.(6919-6921)TCC>TTC	p.S2307F	LAMA1_uc002knl.2_5'Flank|LAMA1_uc010wzj.1_Missense_Mutation_p.S1783F	NM_005559	NP_005550	P25391	LAMA1_HUMAN	laminin, alpha 1 precursor	2307	Laminin G-like 2.				axon guidance|cell adhesion|cell surface receptor linked signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	extracellular space|laminin-1 complex|laminin-3 complex	extracellular matrix structural constituent|receptor binding			ovary(8)|large_intestine(4)|upper_aerodigestive_tract(2)|breast(2)|skin(2)|pancreas(2)|central_nervous_system(1)	21		Colorectal(10;0.172)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AAAATGGAAGGAAGGGTCTTC	0.448		NaN											0	0	0	1	0	9	20									
KIAA0802	23255	broad.mit.edu	37	18	8825631	8825631	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr18:8825631G>A	uc002knr.2	+	15	4265	c.4123G>A	c.(4123-4125)GAG>AAG	p.E1375K	KIAA0802_uc002knq.2_Missense_Mutation_p.E1334K|KIAA0802_uc002kns.2_Missense_Mutation_p.E715K	NM_015210	NP_056025	Q9Y4B5	CC165_HUMAN	hypothetical protein LOC23255	1685											0						CCCTGCCATCGAGAAGGTGCA	0.607		NaN											0	0	0	1	0	10	22									
TAF4B	6875	broad.mit.edu	37	18	23915183	23915183	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr18:23915183G>A	uc002kvu.3	+	13	2793	c.2304G>A	c.(2302-2304)CAG>CAA	p.Q768Q	TAF4B_uc002kvs.3_RNA|TAF4B_uc002kvt.3_Silent_p.Q773Q	NM_005640	NP_005631	Q92750	TAF4B_HUMAN	TAF4b RNA polymerase II, TATA box binding	768	Potential.				transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleolus|transcription factor TFIID complex	DNA binding|NF-kappaB binding|sequence-specific DNA binding transcription factor activity			lung(1)|central_nervous_system(1)|skin(1)	3	all_cancers(21;0.00151)|Lung NSC(5;0.000401)|all_lung(6;0.00115)|Ovarian(20;0.124)		Epithelial(2;9.57e-07)|all cancers(3;5.15e-06)|OV - Ovarian serous cystadenocarcinoma(3;1.96e-05)|LUSC - Lung squamous cell carcinoma(2;0.00594)|Lung(2;0.0267)			GATTAAAGCAGAAAGCCAAAG	0.383		NaN											0	0	0	1	0	8	23									
KLHL14	57565	broad.mit.edu	37	18	30350474	30350474	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr18:30350474C>A	uc002kxm.1	-	2	469	c.81G>T	c.(79-81)TGG>TGT	p.W27C		NM_020805	NP_065856	Q9P2G3	KLH14_HUMAN	kelch-like 14	27						cytosol|endoplasmic reticulum membrane				ovary(1)	1						GCTGCTTCCTCCACAGCAGGT	0.642		NaN											1	0	2.70639e-06	1	2.76511e-06	21	22									
ATP8B1	5205	broad.mit.edu	37	18	55368464	55368464	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr18:55368464C>T	uc002lgw.2	-	4	475	c.475G>A	c.(475-477)GAC>AAC	p.D159N	uc002lgv.1_Intron	NM_005603	NP_005594	O43520	AT8B1_HUMAN	ATPase, class I, type 8B, member 1	159	Cytoplasmic (Potential).				ATP biosynthetic process|bile acid and bile salt transport|negative regulation of transcription, DNA-dependent	apical plasma membrane|integral to plasma membrane|membrane fraction	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			breast(5)|ovary(2)|central_nervous_system(2)|lung(1)	10		Colorectal(73;0.229)				TCCACCAGGTCTTTGATTGCA	0.463		NaN							Byler_disease				0	0	0	1	0	14	27									
PCSK4	54760	broad.mit.edu	37	19	1487786	1487786	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:1487786G>A	uc002ltb.1	-	5	653	c.591C>T	c.(589-591)AAC>AAT	p.N197N	PCSK4_uc002lta.2_Missense_Mutation_p.T39I	NM_017573	NP_060043	Q6UW60	PCSK4_HUMAN	proprotein convertase subtilisin/kexin type 4	197	Catalytic (By similarity).				proteolysis	integral to membrane	serine-type endopeptidase activity				0		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CTGCTCACCGGTTCTCTTTGC	0.682		NaN											0	0	0	1	0	6	3									
ADAMTSL5	339366	broad.mit.edu	37	19	1508069	1508069	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:1508069C>T	uc002ltd.2	-	7	973	c.529G>A	c.(529-531)GAG>AAG	p.E177K	ADAMTSL5_uc010dsl.2_5'UTR|ADAMTSL5_uc010xgq.1_Missense_Mutation_p.E187K	NM_213604	NP_998769	Q6ZMM2	ATL5_HUMAN	ADAMTS-like 5 precursor	177						proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Acute lymphoblastic leukemia(61;5.61e-13)|all_hematologic(61;2.65e-08)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CAGCGGTCCTCGAGGGCACCC	0.682		NaN											0	0	0	1	0	6	11									
ATP8B3	148229	broad.mit.edu	37	19	1785612	1785612	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:1785612G>A	uc002ltw.2	-	26	3483	c.3249C>T	c.(3247-3249)ATC>ATT	p.I1083I	ATP8B3_uc002ltv.2_Silent_p.I1046I|ATP8B3_uc002ltx.2_RNA	NM_138813	NP_620168	O60423	AT8B3_HUMAN	ATPase, class I, type 8B, member 3	1083	Helical; (Potential).				ATP biosynthetic process		ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CACCATGGGCGATGGCTTGGA	0.607		NaN											0	0	0	1	0	6	10									
C3	718	broad.mit.edu	37	19	6678241	6678241	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:6678241C>T	uc002mfm.2	-	40	4834	c.4772G>A	c.(4771-4773)AGA>AAA	p.R1591K	C3_uc002mfl.2_Missense_Mutation_p.R327K	NM_000064	NP_000055	P01024	CO3_HUMAN	complement component 3 precursor	1591	NTR.				complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			skin(3)|ovary(1)|pancreas(1)	5				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		CAGGGCTTCTCTGCACTTGAT	0.587		NaN											0	0	0	1	0	16	31									
MUC16	94025	broad.mit.edu	37	19	9057637	9057637	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:9057637C>T	uc002mkp.2	-	3	30013	c.29809G>A	c.(29809-29811)GAA>AAA	p.E9937K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	9939	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GTGATCACTTCAGTGATGATG	0.453		NaN											0	0	0	1	0	64	115									
EPOR	2057	broad.mit.edu	37	19	11489167	11489167	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:11489167C>T	uc002mrj.1	-	8	1156	c.1020G>A	c.(1018-1020)GGG>GGA	p.G340G	EPOR_uc002mrh.2_5'UTR|EPOR_uc002mri.2_Silent_p.G167G|EPOR_uc002mrk.1_Silent_p.G167G|EPOR_uc002mrl.1_RNA|EPOR_uc010xlx.1_RNA|EPOR_uc010xly.1_Silent_p.G167G	NM_000121	NP_000112	P19235	EPOR_HUMAN	erythropoietin receptor precursor	340	Cytoplasmic (Potential).					extracellular region|integral to plasma membrane	erythropoietin receptor activity|identical protein binding			ovary(1)	1					Darbepoetin alfa(DB00012)|Epoetin alfa(DB00016)	CCTGCATCGTCCCCCAGCAGC	0.632		NaN											0	0	0	1	0	17	21									
ZNF441	126068	broad.mit.edu	37	19	11890924	11890924	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:11890924G>A	uc010dyj.2	+	4	479	c.285G>A	c.(283-285)GAG>GAA	p.E95E	ZNF441_uc002msn.3_Silent_p.E51E	NM_152355	NP_689568	Q8N8Z8	ZN441_HUMAN	zinc finger protein 441	95					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TTGTGAACGAGAAAATACCTG	0.413		NaN											0	0	0	1	0	21	53									
KLF1	10661	broad.mit.edu	37	19	12997900	12997900	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:12997900G>A	uc002mvo.2	-	1	118	c.55C>T	c.(55-57)CCC>TCC	p.P19S		NM_006563	NP_006554	Q13351	KLF1_HUMAN	erythroid Kruppel-like factor	19	Pro-rich.				erythrocyte differentiation|positive regulation of transcription, DNA-dependent	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding				0		Hepatocellular(1079;0.137)		GBM - Glioblastoma multiforme(1328;0.00016)|Lung(535;0.171)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCGGGAAGGGGCCCAGGGCG	0.657		NaN											0	0	0	1	0	23	38									
AKAP8L	26993	broad.mit.edu	37	19	15512157	15512157	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:15512157G>A	uc002naw.1	-	5	719	c.620C>T	c.(619-621)GCC>GTC	p.A207V	AKAP8L_uc002nax.1_RNA|AKAP8L_uc010xoh.1_Missense_Mutation_p.A146V|AKAP8L_uc002nay.1_Missense_Mutation_p.A207V|AKAP8L_uc002naz.2_Missense_Mutation_p.A55V	NM_014371	NP_055186	Q9ULX6	AKP8L_HUMAN	A kinase (PRKA) anchor protein 8-like	207						cytoplasm|nuclear matrix	DEAD/H-box RNA helicase binding|DNA binding|zinc ion binding			ovary(1)	1						CTGGCCCCGGGCCCCCATGGG	0.692		NaN											0	0	0	1	0	13	54									
FCHO1	23149	broad.mit.edu	37	19	17889421	17889421	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:17889421C>T	uc010ebb.2	+	19	1544	c.1355C>T	c.(1354-1356)TCT>TTT	p.S452F	FCHO1_uc002nhg.3_Missense_Mutation_p.S452F|FCHO1_uc002nhh.2_Missense_Mutation_p.S452F|FCHO1_uc010xpw.1_Missense_Mutation_p.S402F|FCHO1_uc002nhi.2_5'UTR|FCHO1_uc002nhj.2_5'UTR	NM_001161358	NP_001154830	O14526	FCHO1_HUMAN	FCH domain only 1 isoform b	452										breast(1)	1						CCCCAAGGCTCTAGCAGCCTG	0.682		NaN											0	0	0	1	0	3	2									
IL12RB1	3594	broad.mit.edu	37	19	18174783	18174783	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:18174783G>A	uc002nhw.1	-	13	1585	c.1521C>T	c.(1519-1521)CTC>CTT	p.L507L	IL12RB1_uc010xqb.1_Silent_p.L507L|IL12RB1_uc002nhx.1_Silent_p.L547L	NM_005535	NP_005526	P42701	I12R1_HUMAN	interleukin 12 receptor, beta 1 isoform 1	507	Extracellular (Potential).|Fibronectin type-III 5.				cellular response to interferon-gamma|interleukin-12-mediated signaling pathway|positive regulation of activated T cell proliferation|positive regulation of defense response to virus by host|positive regulation of interferon-gamma production|positive regulation of memory T cell differentiation|positive regulation of T cell mediated cytotoxicity|positive regulation of T-helper 1 type immune response|positive regulation of T-helper 17 cell lineage commitment|positive regulation of T-helper 17 type immune response	interleukin-12 receptor complex|interleukin-23 receptor complex	cytokine receptor activity			pancreas(1)	1						GCAGGCCACTGAGGGTAACTT	0.647		NaN											0	0	0	1	0	9	19									
ZNF93	81931	broad.mit.edu	37	19	20044424	20044424	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:20044424G>C	uc002non.2	+	4	771	c.660G>C	c.(658-660)AAG>AAC	p.K220N		NM_031218	NP_112495	P35789	ZNF93_HUMAN	zinc finger protein 93	220	C2H2-type 3.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)	1						ATACACATAAGAGAATTCATA	0.368		NaN											0	0	0	1	0	11	31									
ZNF257	113835	broad.mit.edu	37	19	22271978	22271978	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:22271978C>G	uc010ecx.2	+	4	1595	c.1426C>G	c.(1426-1428)CAA>GAA	p.Q476E	ZNF257_uc010ecy.2_Missense_Mutation_p.Q444E	NM_033468	NP_258429	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	476	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.0961)|Lung NSC(12;0.103)				ACACCTTACTCAACATAAAAT	0.383		NaN											0	0	0	1	0	16	31									
ETV2	2116	broad.mit.edu	37	19	36135582	36135582	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:36135582G>C	uc002oas.2	+	6	1380	c.941G>C	c.(940-942)AGA>ACA	p.R314T	ETV2_uc002oar.2_Missense_Mutation_p.R286T|ETV2_uc002oat.2_Missense_Mutation_p.R193T|ETV2_uc002oau.2_Missense_Mutation_p.R99T	NM_014209	NP_055024	O00321	ETV2_HUMAN	ets variant gene 2	285							sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GAGCGCAAGAGAAAGCCGGGC	0.672		NaN											0	0	0	1	0	4	18									
ZBTB32	27033	broad.mit.edu	37	19	36206116	36206116	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:36206116C>T	uc002oay.2	+	2	798	c.588C>T	c.(586-588)CTC>CTT	p.L196L	ZBTB32_uc002oaz.2_RNA|MLL4_uc010eei.2_5'Flank	NM_014383	NP_055198	Q9Y2Y4	ZBT32_HUMAN	zinc finger and BTB domain containing 32	196					DNA repair|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding			ovary(1)|skin(1)	2	all_lung(56;2.22e-07)|Lung NSC(56;3.47e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AGAAACGCCTCCAAGCCCCTG	0.587		NaN											0	0	0	1	0	18	40									
PSG3	5671	broad.mit.edu	37	19	43236942	43236942	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:43236942G>C	uc002oue.2	-	3	835	c.703C>G	c.(703-705)CTC>GTC	p.L235V	PSG3_uc002ouf.2_RNA|PSG1_uc002oug.1_Intron|PSG3_uc010eil.2_Missense_Mutation_p.L257V	NM_021016	NP_066296	Q16557	PSG3_HUMAN	pregnancy specific beta-1-glycoprotein 3	235					defense response|female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00682)				TCACGGAGGAGATTCAGGGTG	0.537		NaN											0	0	0	1	0	98	270									
DHDH	27294	broad.mit.edu	37	19	49445720	49445720	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:49445720C>T	uc002ple.1	+	5	683	c.643C>T	c.(643-645)CTC>TTC	p.L215F		NM_014475	NP_055290	Q9UQ10	DHDH_HUMAN	dimeric dihydrodiol dehydrogenase	215					carbohydrate metabolic process		binding|D-xylose 1-dehydrogenase (NADP+) activity|electron carrier activity|NAD(P)+ transhydrogenase activity|trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity				0		all_epithelial(76;5.29e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000158)|all cancers(93;0.000258)|Epithelial(262;0.0173)|GBM - Glioblastoma multiforme(486;0.0179)		TGTCACGGTGCTCCTGCAGTA	0.428		NaN											0	0	0	1	0	6	21									
ZNF613	79898	broad.mit.edu	37	19	52448420	52448420	+	Silent	SNP	T	T	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:52448420T>C	uc002pxz.1	+	6	1707	c.1284T>C	c.(1282-1284)TAT>TAC	p.Y428Y	ZNF613_uc002pya.1_Silent_p.Y392Y	NM_001031721	NP_001026891	Q6PF04	ZN613_HUMAN	zinc finger protein 613 isoform 1	428	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00148)|OV - Ovarian serous cystadenocarcinoma(262;0.0183)		AGAAACCCTATGTATGCAATG	0.423		NaN											0	0	0	1	0	30	32									
VSTM1	284415	broad.mit.edu	37	19	54545036	54545036	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:54545036G>A	uc002qcw.3	-	8	764	c.588C>T	c.(586-588)CTC>CTT	p.L196L	VSTM1_uc010erb.2_RNA|VSTM1_uc002qcx.3_Silent_p.L165L	NM_198481	NP_940883	Q6UX27	VSTM1_HUMAN	V-set and transmembrane domain containing 1	196						integral to membrane					0	all_cancers(19;0.0128)|all_epithelial(19;0.00564)|all_lung(19;0.031)|Lung NSC(19;0.0358)|Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.165)		GACTCACCGAGAGAGATACCC	0.463		NaN											0	0	0	1	0	7	10									
CNOT3	4849	broad.mit.edu	37	19	54649696	54649696	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:54649696G>A	uc002qdj.1	+	9	1065	c.754G>A	c.(754-756)GAG>AAG	p.E252K	CNOT3_uc010yel.1_Missense_Mutation_p.E252K|CNOT3_uc002qdi.2_Missense_Mutation_p.E165K|CNOT3_uc002qdk.1_Missense_Mutation_p.E252K|CNOT3_uc010ere.1_RNA	NM_014516	NP_055331	O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	252					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CATGGAGGATGAGATCTTCAA	0.642		NaN											0	0	0	1	0	15	25									
ZNF548	147694	broad.mit.edu	37	19	57911010	57911010	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:57911010G>A	uc002qom.2	+	3	1605	c.1355G>A	c.(1354-1356)AGA>AAA	p.R452K	ZNF547_uc002qpm.3_Intron|ZNF548_uc002qon.2_Missense_Mutation_p.R455K	NM_152909	NP_690873	Q8NEK5	ZN548_HUMAN	zinc finger protein 548	452	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		TACGAGTGCAGAGAGTGTGGG	0.468		NaN											0	0	0	1	0	18	32									
SLC27A5	10998	broad.mit.edu	37	19	59012064	59012064	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr19:59012064C>T	uc002qtc.2	-	5	1302	c.1192G>A	c.(1192-1194)GAC>AAC	p.D398N	SLC27A5_uc002qtb.2_5'Flank	NM_012254	NP_036386	Q9Y2P5	S27A5_HUMAN	solute carrier family 27 (fatty acid	398	Cytoplasmic (Probable).				bile acid and bile salt transport|bile acid biosynthetic process|very long-chain fatty acid metabolic process	endoplasmic reticulum membrane|integral to membrane	ATP binding|cholate-CoA ligase activity|long-chain fatty acid-CoA ligase activity				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.181)		TGTGTCCGGTCCTCTGGTTGC	0.572		NaN											0	0	0	1	0	17	22									
TPO	7173	broad.mit.edu	37	2	1460027	1460027	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:1460027G>A	uc002qww.2	+	7	883	c.792G>A	c.(790-792)GAG>GAA	p.E264E	TPO_uc010ewj.2_Intron|TPO_uc002qwu.2_Silent_p.E264E|TPO_uc002qwr.2_Silent_p.E264E|TPO_uc002qwx.2_Silent_p.E264E|TPO_uc010yio.1_Silent_p.E264E|TPO_uc010yip.1_Silent_p.E264E	NM_000547	NP_000538	P07202	PERT_HUMAN	thyroid peroxidase isoform a	264	Extracellular (Potential).				cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			ovary(7)|pancreas(6)|skin(5)|lung(1)|kidney(1)	20	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	TGACTTGTGAGAACCAAAACC	0.443		NaN											0	0	0	1	0	8	30									
HADHA	3030	broad.mit.edu	37	2	26424095	26424095	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:26424095C>G	uc002rgy.2	-	13	1445	c.1315G>C	c.(1315-1317)GAA>CAA	p.E439Q	HADHA_uc010yks.1_Missense_Mutation_p.E352Q	NM_000182	NP_000173	P40939	ECHA_HUMAN	mitochondrial trifunctional protein, alpha	439					fatty acid beta-oxidation	fatty acid beta-oxidation multienzyme complex|mitochondrial nucleoid|nucleolus	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acetyltransferase activity|coenzyme binding|enoyl-CoA hydratase activity|long-chain-3-hydroxyacyl-CoA dehydrogenase activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				NADH(DB00157)	TCGGCCTTTTCAAAACCTTGG	0.423		NaN											0	0	0	1	0	16	39									
HADHB	3032	broad.mit.edu	37	2	26486347	26486347	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:26486347C>T	uc002rgz.2	+	4	460	c.209C>T	c.(208-210)TCA>TTA	p.S70L	HADHB_uc010yku.1_RNA|HADHB_uc010ykv.1_Missense_Mutation_p.S48L|HADHB_uc010ykw.1_Missense_Mutation_p.S70L|HADHB_uc002rha.2_Missense_Mutation_p.S70L	NM_000183	NP_000174	P55084	ECHB_HUMAN	mitochondrial trifunctional protein, beta	70					fatty acid beta-oxidation	mitochondrial nucleoid	3-hydroxyacyl-CoA dehydrogenase activity|acetyl-CoA C-acyltransferase activity|enoyl-CoA hydratase activity|protein binding			ovary(1)|breast(1)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTGGCACTTCGTAAGTATGA	0.378		NaN											0	0	0	1	0	16	57									
LBH	81606	broad.mit.edu	37	2	30457350	30457350	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:30457350C>T	uc002rne.2	+	2	314	c.106C>T	c.(106-108)CGC>TGC	p.R36C		NM_030915	NP_112177	Q53QV2	LBH_HUMAN	limb bud and heart development homolog	36					multicellular organismal development|transcription, DNA-dependent	cytoplasm|nucleolus					0	Acute lymphoblastic leukemia(172;0.155)					CCTCAGCCCCCGCAAGGATGG	0.498		NaN											0	0	0	1	0	16	52									
PRKD3	23683	broad.mit.edu	37	2	37513430	37513430	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:37513430C>G	uc002rqd.2	-	5	1355	c.800G>C	c.(799-801)AGA>ACA	p.R267T	PRKD3_uc002rqf.1_Missense_Mutation_p.R267T	NM_005813	NP_005804	O94806	KPCD3_HUMAN	protein kinase D3	267					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(2)|ovary(1)|central_nervous_system(1)	4		all_hematologic(82;0.21)				AACTTTCACTCTGCACATTAC	0.448		NaN											0	0	0	1	0	18	47									
PRKD3	23683	broad.mit.edu	37	2	37513444	37513444	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:37513444C>A	uc002rqd.2	-	5	1341	c.786G>T	c.(784-786)AAG>AAT	p.K262N	PRKD3_uc002rqf.1_Missense_Mutation_p.K262N	NM_005813	NP_005804	O94806	KPCD3_HUMAN	protein kinase D3	262					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(2)|ovary(1)|central_nervous_system(1)	4		all_hematologic(82;0.21)				ACATTACCATCTTTTCCATCC	0.433		NaN											1	0	1.15088e-07	1	1.1852e-07	14	53									
LRPPRC	10128	broad.mit.edu	37	2	44170868	44170868	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:44170868G>A	uc002rtr.2	-	23	2520	c.2462C>T	c.(2461-2463)TCC>TTC	p.S821F	LRPPRC_uc010yob.1_Missense_Mutation_p.S721F	NM_133259	NP_573566	P42704	LPPRC_HUMAN	leucine-rich PPR motif-containing protein	821	PPR 13.				mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			ovary(2)|skin(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TATGTTGGTGGATGGTTCTGC	0.358		NaN											0	0	0	1	0	32	108									
USP34	9736	broad.mit.edu	37	2	61622361	61622361	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:61622361G>A	uc002sbe.2	-	4	582	c.560C>T	c.(559-561)TCA>TTA	p.S187L		NM_014709	NP_055524	Q70CQ2	UBP34_HUMAN	ubiquitin specific protease 34	187					positive regulation of canonical Wnt receptor signaling pathway|protein K48-linked deubiquitination|ubiquitin-dependent protein catabolic process|Wnt receptor signaling pathway		cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(8)|breast(5)|skin(3)|lung(2)|prostate(1)	19			Epithelial(17;0.229)			TTCTTGAGTTGATATATCCTA	0.234		NaN											0	0	0	1	0	13	21									
C2orf86	51057	broad.mit.edu	37	2	63349172	63349172	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:63349172G>A	uc002sch.2	-	18	2656	c.2210C>T	c.(2209-2211)TCT>TTT	p.S737F	C2orf86_uc002sce.2_RNA|C2orf86_uc002scf.2_Missense_Mutation_p.S578F|C2orf86_uc010ypu.1_RNA|C2orf86_uc002scg.2_Missense_Mutation_p.S545F	NM_015910	NP_056994	O95876	FRITZ_HUMAN	hypothetical protein LOC51057 isoform 2	737					cilium morphogenesis|regulation of embryonic cell shape|regulation of protein localization|septin cytoskeleton organization	cilium axoneme|cytoplasm|cytoskeleton|plasma membrane					0						CATTTTGAGAGAACCACCATC	0.279		NaN											0	0	0	1	0	15	59									
ATP6V1B1	525	broad.mit.edu	37	2	71189911	71189911	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:71189911G>A	uc002shj.2	+	9	877	c.790G>A	c.(790-792)GAG>AAG	p.E264K	ATP6V1B1_uc010fdv.2_Missense_Mutation_p.E264K|ATP6V1B1_uc010fdw.2_RNA|ATP6V1B1_uc010fdx.2_Missense_Mutation_p.E222K	NM_001692	NP_001683	P15313	VATB1_HUMAN	ATPase, H+ transporting, lysosomal 56/58kDa, V1	264					ATP hydrolysis coupled proton transport|calcium ion homeostasis|cellular iron ion homeostasis|excretion|inner ear morphogenesis|insulin receptor signaling pathway|ossification|pH reduction|sensory perception of sound|transferrin transport	apical plasma membrane|basolateral plasma membrane|cytosol|endomembrane system|lateral plasma membrane|microvillus|proton-transporting V-type ATPase, V1 domain|vacuolar proton-transporting V-type ATPase complex	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			skin(1)	1						CTCCAGGATCGAGCGGATCAT	0.582		NaN											0	0	0	1	0	10	59									
LBX2	85474	broad.mit.edu	37	2	74725261	74725261	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:74725261G>A	uc002slv.3	-	2	395	c.390C>T	c.(388-390)GTC>GTT	p.V130V	LBX2_uc002slw.2_Silent_p.V126V	NM_001009812	NP_001009812	Q6XYB7	LBX2_HUMAN	ladybird homeobox 2	130	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GGAACCAAGTGACCACCTGCG	0.667		NaN											0	0	0	1	0	15	34									
SFTPB	6439	broad.mit.edu	37	2	85893860	85893860	+	Silent	SNP	C	C	T	rs45478492		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:85893860C>T	uc002sqh.2	-	4	279	c.273G>A	c.(271-273)ACG>ACA	p.T91T	SFTPB_uc002sqi.2_Silent_p.T103T|SFTPB_uc002sqj.2_Silent_p.T91T	NM_198843	NP_942140	P07988	PSPB_HUMAN	surfactant, pulmonary-associated protein B	91	Saposin B-type 1.				organ morphogenesis|respiratory gaseous exchange|sphingolipid metabolic process	extracellular space|lysosome				ovary(1)|central_nervous_system(1)	2						ACTTCCTCATCGTGTCCTGGG	0.632		NaN											0	0	0	1	0	43	103									
FER1L5	90342	broad.mit.edu	37	2	97365429	97365429	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:97365429C>T	uc010fia.2	+	42	4834	c.4834C>T	c.(4834-4836)CAT>TAT	p.H1612Y	FER1L5_uc002sws.3_Missense_Mutation_p.H330Y|FER1L5_uc002swt.3_Missense_Mutation_p.H330Y|FER1L5_uc010yus.1_Missense_Mutation_p.H329Y	NM_001113382	NP_001106853	A0AVI2	FR1L5_HUMAN	fer-1-like 5 isoform 2	1612						integral to membrane				ovary(1)	1						CTTTGGAGCTCATTGTGGGCT	0.527		NaN											0	0	0	1	0	38	80									
TMEM131	23505	broad.mit.edu	37	2	98382950	98382950	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:98382950T>C	uc002syh.3	-	34	4793	c.4564A>G	c.(4564-4566)AAA>GAA	p.K1522E		NM_015348	NP_056163	Q92545	TM131_HUMAN	RW1 protein	1522						integral to membrane				ovary(4)|central_nervous_system(2)	6						CCTTTTGTTTTCTGGGCATTT	0.393		NaN											0	0	0	1	0	15	46									
TBC1D8	11138	broad.mit.edu	37	2	101656805	101656805	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:101656805G>A	uc010fiv.2	-	6	1001	c.870C>T	c.(868-870)TTC>TTT	p.F290F	TBC1D8_uc010yvw.1_Silent_p.F305F|TBC1D8_uc002tau.3_Silent_p.F47F	NM_001102426	NP_001095896	O95759	TBCD8_HUMAN	TBC1 domain family, member 8	290	GRAM 2.				blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			ovary(3)	3						GCAACCTGAAGAAAGCCCGGA	0.572		NaN											0	0	0	1	0	6	16									
RGPD4	285190	broad.mit.edu	37	2	108496500	108496500	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:108496500T>A	uc010ywk.1	+	21	5083	c.5001T>A	c.(4999-5001)GAT>GAA	p.D1667E	RGPD4_uc002tdu.2_Missense_Mutation_p.D854E|RGPD4_uc010ywl.1_RNA	NM_182588	NP_872394	Q7Z3J3	RGPD4_HUMAN	RANBP2-like and GRIP domain containing 4	1667					intracellular transport		binding			skin(2)	2						AAAGTGCAGATCACTTAAACG	0.453		NaN											0	0	0	1	0	35	123									
IL1F6	27179	broad.mit.edu	37	2	113763586	113763586	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:113763586C>A	uc010yxr.1	+	2	46	c.46C>A	c.(46-48)CAG>AAG	p.Q16K		NM_014440	NP_055255	Q9UHA7	IL36A_HUMAN	interleukin 1 family, member 6 (epsilon)	16					immune response|inflammatory response	extracellular space	cytokine activity|interleukin-1 receptor binding				0						GGGGAGCATTCAGGATATCAA	0.468		NaN											1	0	3.69857e-22	1	3.90991e-22	29	45									
EPB41L5	57669	broad.mit.edu	37	2	120844814	120844814	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:120844814C>G	uc002tmg.2	+	11	997	c.871C>G	c.(871-873)CAG>GAG	p.Q291E	EPB41L5_uc010flk.2_Missense_Mutation_p.Q291E|EPB41L5_uc010fll.2_Missense_Mutation_p.Q291E|EPB41L5_uc002tmh.3_Missense_Mutation_p.Q291E|EPB41L5_uc010flm.2_Missense_Mutation_p.Q95E	NM_020909	NP_065960	Q9HCM4	E41L5_HUMAN	erythrocyte membrane protein band 4.1 like 5	291	FERM.					cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding			ovary(1)	1						AGATGATGATCAGGTAGGAAT	0.294		NaN											0	0	0	1	0	9	50									
FAM123C	205147	broad.mit.edu	37	2	131521644	131521644	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:131521644C>G	uc002trw.2	+	2	2189	c.1999C>G	c.(1999-2001)CTG>GTG	p.L667V	FAM123C_uc010fmv.2_Missense_Mutation_p.L667V|FAM123C_uc010fms.1_Missense_Mutation_p.L667V|FAM123C_uc010fmt.1_Missense_Mutation_p.L667V|FAM123C_uc010fmu.1_Missense_Mutation_p.L667V	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	667										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		AGGTGACACTCTGGATGCAGA	0.652		NaN											0	0	0	1	0	8	17									
LRP1B	53353	broad.mit.edu	37	2	141816461	141816461	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:141816461G>C	uc002tvj.1	-	9	2371	c.1399C>G	c.(1399-1401)CAA>GAA	p.Q467E	LRP1B_uc010fnl.1_Intron	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	467	Extracellular (Potential).				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CCTGTTGGTTGAGTTCTTTTT	0.358		NaN								TSP Lung(27;0.18)			0	0	0	1	0	10	42									
ARL6IP6	151188	broad.mit.edu	37	2	153591519	153591519	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:153591519C>G	uc002tyn.2	+	3	1182	c.466C>G	c.(466-468)CTA>GTA	p.L156V	ARL6IP6_uc002tym.2_RNA|ARL6IP6_uc002tyo.2_Missense_Mutation_p.L48V	NM_152522	NP_689735	Q8N6S5	AR6P6_HUMAN	ADP-ribosylation-like factor 6 interacting	156	Helical; (Potential).					integral to membrane					0						ATTCTGGACTCTACTTATAAT	0.363		NaN											0	0	0	1	0	25	87									
CCDC148	130940	broad.mit.edu	37	2	159195330	159195330	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:159195330C>G	uc002tzq.2	-	7	935	c.672G>C	c.(670-672)TTG>TTC	p.L224F	CCDC148_uc002tzr.2_Missense_Mutation_p.L72F|CCDC148_uc010foh.2_Intron|CCDC148_uc010foi.1_Missense_Mutation_p.L171F|CCDC148_uc010foj.1_Missense_Mutation_p.L72F|CCDC148_uc010fok.1_Missense_Mutation_p.L138F|CCDC148_uc002tzs.1_Missense_Mutation_p.L224F	NM_138803	NP_620158	Q8NFR7	CC148_HUMAN	coiled-coil domain containing 148	224										ovary(2)	2						TTGAAGATTTCAAATCAGGGT	0.353		NaN											0	0	0	1	0	18	52									
PLA2R1	22925	broad.mit.edu	37	2	160824175	160824175	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:160824175C>T	uc002ube.1	-	20	2986	c.2779G>A	c.(2779-2781)GAA>AAA	p.E927K	PLA2R1_uc010zcp.1_Missense_Mutation_p.E927K|PLA2R1_uc002ubf.2_Missense_Mutation_p.E927K	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor	927	Extracellular (Potential).|C-type lectin 5.				endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						GAACACTCTTCACTACCCCAG	0.403		NaN											0	0	0	1	0	18	87									
FAP	2191	broad.mit.edu	37	2	163076436	163076436	+	Splice_Site	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:163076436C>G	uc002ucd.2	-	7	622	c.414_splice	c.e7-1	p.G138_splice	FAP_uc010zct.1_Splice_Site_p.G113_splice|FAP_uc010fpd.2_Intron|FAP_uc010fpe.1_Splice_Site_p.G105_splice	NM_004460	NP_004451	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha subunit						endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			ovary(3)	3						TACAAATTCTCTAGAAGGAAA	0.294		NaN											0	0	0	1	0	16	28									
SCN3A	6328	broad.mit.edu	37	2	165956858	165956858	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:165956858C>G	uc002ucx.2	-	22	4412	c.3920G>C	c.(3919-3921)AGA>ACA	p.R1307T	SCN3A_uc002ucy.2_Missense_Mutation_p.R1258T|SCN3A_uc002ucz.2_Missense_Mutation_p.R1258T|SCN3A_uc002uda.1_Missense_Mutation_p.R1127T|SCN3A_uc002udb.1_Missense_Mutation_p.R1127T	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	1307	Helical; Voltage-sensor; Name=S4 of repeat III; (Potential).					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	TCTTAAAGCTCTTAATGTCCG	0.378		NaN											0	0	0	1	0	7	66									
SCN2A	6326	broad.mit.edu	37	2	166243479	166243479	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:166243479T>C	uc002udc.2	+	26	5065	c.4775T>C	c.(4774-4776)ATT>ACT	p.I1592T	SCN2A_uc002udd.2_Missense_Mutation_p.I1592T|SCN2A_uc002ude.2_Missense_Mutation_p.I1592T	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	1592	Helical; Name=S3 of repeat IV; (Potential).|IV.				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	TATTTCACTATTGGATGGAAT	0.343		NaN											0	0	0	1	0	18	72									
SCN1A	6323	broad.mit.edu	37	2	166901813	166901813	+	Missense_Mutation	SNP	C	C	G	rs138602926		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:166901813C>G	uc010zcz.1	-	10	1420	c.1402G>C	c.(1402-1404)GAA>CAA	p.E468Q	SCN1A_uc002udo.3_Missense_Mutation_p.E337Q|SCN1A_uc010fpk.2_Missense_Mutation_p.E337Q	NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	468						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CTGGAATGTTCTGAGGCAGTT	0.458		NaN											0	0	0	1	0	8	115									
PDE11A	50940	broad.mit.edu	37	2	178528629	178528629	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:178528629C>A	uc002ulq.2	-	19	2929	c.2611G>T	c.(2611-2613)GAG>TAG	p.E871*	PDE11A_uc010zfd.1_Nonsense_Mutation_p.E62*|PDE11A_uc002ulp.2_Nonsense_Mutation_p.E427*|PDE11A_uc002ulr.2_Nonsense_Mutation_p.E621*|PDE11A_uc002uls.1_Nonsense_Mutation_p.E513*|PDE11A_uc002ult.1_Nonsense_Mutation_p.E621*|PDE11A_uc002ulu.1_Nonsense_Mutation_p.E513*	NM_016953	NP_058649	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A isoform 4	871	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(3)|large_intestine(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			TCAATCCACTCCAGTTGCAAC	0.438		NaN							Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial				1	0	7.93312e-07	1	8.13734e-07	13	51									
PDE11A	50940	broad.mit.edu	37	2	178545621	178545621	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:178545621C>G	uc002ulq.2	-	16	2674	c.2356G>C	c.(2356-2358)GAA>CAA	p.E786Q	PDE11A_uc002ulp.2_Missense_Mutation_p.E342Q|PDE11A_uc002ulr.2_Missense_Mutation_p.E536Q|PDE11A_uc002uls.1_Missense_Mutation_p.E428Q|PDE11A_uc002ult.1_Missense_Mutation_p.E536Q|PDE11A_uc002ulu.1_Missense_Mutation_p.E428Q	NM_016953	NP_058649	Q9HCR9	PDE11_HUMAN	phosphodiesterase 11A isoform 4	786	Catalytic (By similarity).				platelet activation|signal transduction	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|metal ion binding			ovary(3)|large_intestine(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00121)|Epithelial(96;0.00455)|all cancers(119;0.02)			TCAAAGAATTCAGTTCTCCTC	0.353		NaN							Primary_Pigmented_Nodular_Adrenocortical_Disease_Familial				0	0	0	1	0	4	23									
TTN	7273	broad.mit.edu	37	2	179596906	179596906	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:179596906G>C	uc010zfg.1	-	54	13282	c.13058C>G	c.(13057-13059)TCT>TGT	p.S4353C	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.S1014C	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	5280							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AACTGCAGTAGACTCCACAAA	0.433		NaN											0	0	0	1	0	59	151									
ANKRD44	91526	broad.mit.edu	37	2	197870475	197870475	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:197870475C>T	uc002uua.1	-	21	2292	c.2215G>A	c.(2215-2217)GAC>AAC	p.D739N	ANKRD44_uc002utz.3_Missense_Mutation_p.D471N	NM_153697	NP_710181	Q8N8A2	ANR44_HUMAN	ankyrin repeat domain 44	764	ANK 22.						protein binding			ovary(4)|skin(1)	5			OV - Ovarian serous cystadenocarcinoma(117;0.246)			AAACAACAGTCCTCCTCAGAA	0.522		NaN											0	0	0	1	0	10	126									
SATB2	23314	broad.mit.edu	37	2	200137286	200137286	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:200137286G>A	uc002uuy.1	-	11	2667	c.1850C>T	c.(1849-1851)TCT>TTT	p.S617F	SATB2_uc010fsq.1_Missense_Mutation_p.S499F|SATB2_uc002uuz.1_Missense_Mutation_p.S617F|SATB2_uc002uva.1_Missense_Mutation_p.S617F	NM_015265	NP_056080	Q9UPW6	SATB2_HUMAN	SATB homeobox 2	617	Homeobox.					cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1						CTTTGTGCGAGACCGGGGCTT	0.557		NaN											0	0	0	1	0	24	66									
ABI2	10152	broad.mit.edu	37	2	204244965	204244965	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:204244965G>A	uc002vaa.2	+	3	555	c.320G>A	c.(319-321)AGA>AAA	p.R107K	ABI2_uc010zig.1_RNA|ABI2_uc002uzz.2_Missense_Mutation_p.R107K|ABI2_uc010zih.1_Intron|ABI2_uc010zii.1_Missense_Mutation_p.R107K|ABI2_uc010zij.1_Missense_Mutation_p.R51K|ABI2_uc002vab.2_Missense_Mutation_p.R62K|ABI2_uc010zik.1_5'UTR|ABI2_uc010zil.1_5'UTR|ABI2_uc010zim.1_5'UTR	NM_005759	NP_005750	Q9NYB9	ABI2_HUMAN	abl interactor 2	107	t-SNARE coiled-coil homology.				actin polymerization or depolymerization|cell migration|peptidyl-tyrosine phosphorylation	cytoskeleton|cytosol|filopodium|lamellipodium	cytoskeletal adaptor activity|DNA binding|kinase binding|proline-rich region binding|SH3 domain binding|ubiquitin protein ligase binding				0						GTTGCAAGAAGAGAAATTGGT	0.299		NaN											0	0	0	1	0	17	48									
PIKFYVE	200576	broad.mit.edu	37	2	209190134	209190134	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:209190134C>G	uc002vcz.2	+	20	2757	c.2599C>G	c.(2599-2601)CAA>GAA	p.Q867E	PIKFYVE_uc010fun.1_Missense_Mutation_p.Q548E|PIKFYVE_uc002vcy.1_Missense_Mutation_p.Q811E	NM_015040	NP_055855	Q9Y2I7	FYV1_HUMAN	phosphatidylinositol-3-phosphate 5-kinase type	867					cellular protein metabolic process|intracellular signal transduction|protein localization to nucleus|retrograde transport, endosome to Golgi	early endosome membrane|membrane raft	1-phosphatidylinositol-3-phosphate 5-kinase activity|1-phosphatidylinositol-4-phosphate 5-kinase activity|ATP binding|metal ion binding|protein binding			ovary(5)|kidney(2)|pancreas(1)|central_nervous_system(1)|skin(1)	10						TTATCATTCTCAACTAGAAAT	0.433		NaN											0	0	0	1	0	19	64									
PTH2R	5746	broad.mit.edu	37	2	209307167	209307167	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:209307167C>G	uc002vdb.2	+	5	703	c.490C>G	c.(490-492)CTC>GTC	p.L164V	PTH2R_uc010zjb.1_Missense_Mutation_p.L175V	NM_005048	NP_005039	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor precursor	164	Helical; Name=1; (Potential).					integral to plasma membrane	parathyroid hormone receptor activity			ovary(1)|breast(1)|skin(1)	3				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		TGTGGCTATTCTCATCATTGG	0.438		NaN											0	0	0	1	0	34	82									
MAP2	4133	broad.mit.edu	37	2	210558518	210558518	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:210558518G>T	uc002vde.1	+	7	1872	c.1624G>T	c.(1624-1626)GAT>TAT	p.D542Y	MAP2_uc002vdc.1_Missense_Mutation_p.D542Y|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Missense_Mutation_p.D538Y	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	542					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	AATGAGAGTTGATGACAAAGA	0.383		NaN											1	0	2.12542e-12	1	2.21969e-12	28	64									
C2orf24	27013	broad.mit.edu	37	2	220039607	220039607	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:220039607A>G	uc002vju.3	-	5	555	c.403T>C	c.(403-405)TAT>CAT	p.Y135H	C2orf24_uc002vjv.2_Missense_Mutation_p.Y135H	NM_015680	NP_056495	Q9BV87	CNPD1_HUMAN	hypothetical protein LOC27013	135					regulation of cyclin-dependent protein kinase activity	integral to membrane	protein kinase binding				0		Renal(207;0.0915)		Epithelial(149;8.92e-07)|all cancers(144;0.000151)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTTCATCATAGAGGTACTTA	0.582		NaN											0	0	0	1	0	19	42									
EPHA4	2043	broad.mit.edu	37	2	222347094	222347094	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:222347094G>A	uc002vmq.2	-	5	1338	c.1296C>T	c.(1294-1296)GTC>GTT	p.V432V	EPHA4_uc002vmr.2_Silent_p.V432V|EPHA4_uc010zlm.1_Silent_p.V373V|EPHA4_uc010zln.1_Silent_p.V432V	NM_004438	NP_004429	P54764	EPHA4_HUMAN	ephrin receptor EphA4 precursor	432	Extracellular (Potential).|Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity			lung(6)|large_intestine(2)|central_nervous_system(2)|urinary_tract(1)|skin(1)	12		Renal(207;0.0183)		Epithelial(121;5.38e-09)|all cancers(144;2.47e-06)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(261;0.0154)		TGGTCACAGTGACAGAAACTG	0.373		NaN											0	0	0	1	0	8	125									
ALPPL2	251	broad.mit.edu	37	2	233274450	233274450	+	Silent	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:233274450C>G	uc002vss.3	+	11	1520	c.1467C>G	c.(1465-1467)CCC>CCG	p.P489P		NM_031313	NP_112603	P10696	PPBN_HUMAN	placental-like alkaline phosphatase	489					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			skin(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	GCCTGGAGCCCTACACCGCCT	0.741		NaN											0	0	0	1	0	5	9									
INPP5D	3635	broad.mit.edu	37	2	234102561	234102561	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:234102561G>C	uc010zmo.1	+	22	2703	c.2550G>C	c.(2548-2550)GAG>GAC	p.E850D	INPP5D_uc010zmp.1_Missense_Mutation_p.E849D	NM_001017915	NP_001017915	Q92835	SHIP1_HUMAN	SH2 containing inositol phosphatase isoform a	850					apoptosis|blood coagulation|leukocyte migration|T cell receptor signaling pathway	cytosol	inositol-polyphosphate 5-phosphatase activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|SH3 domain binding			ovary(1)|central_nervous_system(1)	2		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0273)|Acute lymphoblastic leukemia(138;0.0328)|Lung NSC(271;0.0843)		Epithelial(121;1.16e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000479)|LUSC - Lung squamous cell carcinoma(224;0.00655)|Lung(119;0.00802)|GBM - Glioblastoma multiforme(43;0.0185)		TCCAGGGGGAGATCAAGCTGC	0.617		NaN											0	0	0	1	0	15	50									
USP40	55230	broad.mit.edu	37	2	234429685	234429685	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:234429685C>G	uc010zmr.1	-	16	2310	c.2310G>C	c.(2308-2310)CAG>CAC	p.Q770H	USP40_uc010zmt.1_Missense_Mutation_p.Q414H	NM_018218	NP_060688	Q9NVE5	UBP40_HUMAN	ubiquitin thioesterase 40	758					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			ovary(1)|lung(1)|breast(1)	3		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0539)		Epithelial(121;1.71e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000407)|Lung(119;0.00277)|LUSC - Lung squamous cell carcinoma(224;0.00646)		CAGATTCTAACTGGCATAAAT	0.343		NaN											0	0	0	1	0	9	27									
CHGB	1114	broad.mit.edu	37	20	5903125	5903125	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:5903125T>C	uc002wmg.2	+	4	641	c.335T>C	c.(334-336)ATC>ACC	p.I112T	CHGB_uc010zqz.1_Intron	NM_001819	NP_001810	P05060	SCG1_HUMAN	chromogranin B precursor	112						extracellular region	hormone activity			breast(3)|skin(2)|ovary(1)	6						GAGGAGGACATCCAAGGCCCA	0.602		NaN											0	0	0	1	0	12	28									
SNRPB2	6629	broad.mit.edu	37	20	16719545	16719545	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:16719545C>A	uc002wph.1	+	5	643	c.427C>A	c.(427-429)CAG>AAG	p.Q143K	SNRPB2_uc002wpi.1_Missense_Mutation_p.Q143K	NM_003092	NP_003083	P08579	RU2B_HUMAN	small nuclear ribonucleoprotein polypeptide B''	143						catalytic step 2 spliceosome|nucleoplasm|U2 snRNP	nucleotide binding|protein binding|RNA binding			large_intestine(1)	1						ACCAAATCCTCAGGTAATTTT	0.328		NaN											1	0	2.0095e-06	1	2.05715e-06	6	16									
RALGAPA2	57186	broad.mit.edu	37	20	20563711	20563711	+	Missense_Mutation	SNP	T	T	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:20563711T>A	uc002wrz.2	-	20	2833	c.2690A>T	c.(2689-2691)GAT>GTT	p.D897V	RALGAPA2_uc010gcx.2_Missense_Mutation_p.D601V|RALGAPA2_uc010zsg.1_Missense_Mutation_p.D345V	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	897					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						ATTTGAAGCATCGGTGGGACT	0.463		NaN											0	0	0	1	0	16	26									
ASXL1	171023	broad.mit.edu	37	20	31024321	31024321	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:31024321C>T	uc002wxs.2	+	12	4232	c.3806C>T	c.(3805-3807)TCG>TTG	p.S1269L	ASXL1_uc010geb.2_Missense_Mutation_p.S1160L	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	1269					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding	p.L1266fs*9(1)		haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						CTTACTACCTCGAGAACACCT	0.493		NaN	F|N|Mis		MDS|CMML								0	0	0	1	0	19	60									
NDRG3	57446	broad.mit.edu	37	20	35310978	35310978	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:35310978C>T	uc002xfw.2	-	7	469	c.387G>A	c.(385-387)CTG>CTA	p.L129L	NDRG3_uc002xfx.2_Silent_p.L117L|NDRG3_uc010zvq.1_Silent_p.L34L|NDRG3_uc010zvr.1_Silent_p.L17L	NM_032013	NP_114402	Q9UGV2	NDRG3_HUMAN	N-myc downstream regulated gene 3 isoform a	129					cell differentiation|negative regulation of cell growth|spermatogenesis	cytoplasm				ovary(1)	1		Myeloproliferative disorder(115;0.00878)				TGATGCTTTTCAGGCTGTGAA	0.373		NaN											0	0	0	1	0	39	48									
PPP1R16B	26051	broad.mit.edu	37	20	37524349	37524349	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:37524349C>T	uc002xje.2	+	4	652	c.463C>T	c.(463-465)CAG>TAG	p.Q155*	PPP1R16B_uc010ggc.2_Nonsense_Mutation_p.Q155*	NM_015568	NP_056383	Q96T49	PP16B_HUMAN	protein phosphatase 1 regulatory inhibitor	155	ANK 2.				regulation of filopodium assembly|signal transduction	nucleus|plasma membrane	protein phosphatase binding			upper_aerodigestive_tract(1)|kidney(1)|skin(1)	3		Myeloproliferative disorder(115;0.00878)				GATCCTCGTTCAGTAGTACGT	0.468		NaN											0	0	0	1	0	9	18									
SEMG2	6407	broad.mit.edu	37	20	43850441	43850441	+	Silent	SNP	T	T	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:43850441T>C	uc010ggz.2	+	2	225	c.168T>C	c.(166-168)CAT>CAC	p.H56H	SEMG2_uc002xnk.2_Silent_p.H56H|SEMG2_uc002xnl.2_Silent_p.H56H	NM_003008	NP_002999	Q02383	SEMG2_HUMAN	semenogelin II precursor	56					sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(1)	1		Myeloproliferative disorder(115;0.0122)				ACCAACAACATACTAAATCCA	0.403		NaN											0	0	0	1	0	25	82									
NFATC2	4773	broad.mit.edu	37	20	50140650	50140650	+	Splice_Site	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:50140650C>T	uc002xwd.2	-	2	351	c.131_splice	c.e2-1	p.E44_splice	NFATC2_uc002xwc.2_Splice_Site_p.E44_splice|NFATC2_uc010zyv.1_Intron|NFATC2_uc010zyw.1_Intron|NFATC2_uc010zyx.1_Splice_Site_p.E24_splice|NFATC2_uc010zyy.1_Intron|NFATC2_uc010zyz.1_Intron|NFATC2_uc002xwe.2_Splice_Site_p.E24_splice	NM_173091	NP_775114	Q13469	NFAC2_HUMAN	nuclear factor of activated T-cells,						B cell receptor signaling pathway|positive regulation of B cell proliferation|response to DNA damage stimulus|response to drug	actin cytoskeleton|nucleus|plasma membrane	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Hepatocellular(150;0.248)					TTCGGCTCTTCTGGAAAGAGA	0.537		NaN											0	0	0	1	0	13	32									
SPO11	23626	broad.mit.edu	37	20	55909876	55909876	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:55909876G>C	uc002xye.2	+	6	674	c.581G>C	c.(580-582)TGT>TCT	p.C194S	SPO11_uc002xyf.2_Missense_Mutation_p.C156S	NM_012444	NP_036576	Q9Y5K1	SPO11_HUMAN	meiotic recombination protein SPO11 isoform a	194					female gamete generation|reciprocal meiotic recombination	chromosome|nucleus	ATP binding|DNA binding|hydrolase activity			breast(2)|skin(1)	3	Lung NSC(12;0.0066)|all_lung(29;0.0188)|Melanoma(10;0.242)		BRCA - Breast invasive adenocarcinoma(4;1.73e-14)|Epithelial(14;9.02e-10)|all cancers(14;9.31e-09)			AAAGTGAATTGTACCTGTGGT	0.343		NaN						Editing_and_processing_nucleases					0	0	0	1	0	10	33									
SYCP2	10388	broad.mit.edu	37	20	58467098	58467098	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:58467098C>T	uc002yaz.2	-	23	2450	c.2311G>A	c.(2311-2313)GAG>AAG	p.E771K		NM_014258	NP_055073	Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	771					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			ovary(3)|lung(2)	5	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			AATTCTTTCTCTGCTTTTCTA	0.333		NaN											0	0	0	1	0	15	35									
ADRM1	11047	broad.mit.edu	37	20	60878723	60878723	+	Silent	SNP	G	G	A	rs144780505		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:60878723G>A	uc002ycn.2	+	2	179	c.99G>A	c.(97-99)CTG>CTA	p.L33L	ADRM1_uc011aai.1_Silent_p.L33L|ADRM1_uc002yco.2_Silent_p.L33L|ADRM1_uc002ycp.1_5'Flank	NM_007002	NP_008933	Q16186	ADRM1_HUMAN	adhesion regulating molecule 1 precursor	33	PH.|Interaction with PSMD1.				proteasome assembly|transcription elongation from RNA polymerase II promoter	cytoplasm|integral to plasma membrane|membrane fraction|nucleus|proteasome complex	endopeptidase activator activity|protease binding|proteasome binding				0	Breast(26;7.76e-09)		BRCA - Breast invasive adenocarcinoma(19;2.51e-06)			AGATGTCCCTGAAGGGGACCA	0.597		NaN											0	0	0	1	0	40	82									
DIDO1	11083	broad.mit.edu	37	20	61513083	61513083	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:61513083C>T	uc002ydr.1	-	16	4489	c.4225G>A	c.(4225-4227)GAG>AAG	p.E1409K	DIDO1_uc002yds.1_Missense_Mutation_p.E1409K	NM_033081	NP_149072	Q9BTC0	DIDO1_HUMAN	death inducer-obliterator 1 isoform c	1409					apoptosis|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(3)|skin(3)	6	Breast(26;5.68e-08)					CTTTCCACCTCGTGGCGCCGC	0.602		NaN											0	0	0	1	0	44	72									
CHRNA4	1137	broad.mit.edu	37	20	61991019	61991019	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:61991019C>T	uc002yes.2	-	2	287	c.109G>A	c.(109-111)GAG>AAG	p.E37K	CHRNA4_uc002yet.1_Intron|CHRNA4_uc011aaw.1_RNA|CHRNA4_uc010gke.1_5'UTR|CHRNA4_uc002yev.1_5'UTR|CHRNA4_uc010gkf.1_5'UTR	NM_000744	NP_000735	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 subunit	37	Extracellular (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	AGCCGCTCCTCGGCGTGGGCC	0.667		NaN											0	0	0	1	0	11	28									
STMN3	50861	broad.mit.edu	37	20	62273466	62273466	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:62273466C>G	uc002yfr.1	-	4	560	c.478G>C	c.(478-480)GAG>CAG	p.E160Q	STMN3_uc011abb.1_Missense_Mutation_p.E160Q	NM_015894	NP_056978	Q9NZ72	STMN3_HUMAN	SCG10-like-protein	160	Potential.				cytoplasmic microtubule organization|intracellular signal transduction|negative regulation of Rac protein signal transduction|neuron projection development|regulation of cytoskeleton organization|regulation of Rac GTPase activity	cytoplasm	protein domain specific binding				0	all_cancers(38;2.31e-11)|all_epithelial(29;7.76e-13)		Epithelial(9;1.9e-09)|all cancers(9;1.22e-08)|BRCA - Breast invasive adenocarcinoma(10;8.86e-06)|OV - Ovarian serous cystadenocarcinoma(5;0.00559)			CGCACCTTCTCGCGCAGCCGC	0.368		NaN											0	0	0	1	0	3	15									
STMN3	50861	broad.mit.edu	37	20	62275132	62275132	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr20:62275132C>G	uc002yfr.1	-	3	350	c.268G>C	c.(268-270)GAG>CAG	p.E90Q	STMN3_uc011abb.1_Missense_Mutation_p.E90Q	NM_015894	NP_056978	Q9NZ72	STMN3_HUMAN	SCG10-like-protein	90	Potential.				cytoplasmic microtubule organization|intracellular signal transduction|negative regulation of Rac protein signal transduction|neuron projection development|regulation of cytoskeleton organization|regulation of Rac GTPase activity	cytoplasm	protein domain specific binding				0	all_cancers(38;2.31e-11)|all_epithelial(29;7.76e-13)		Epithelial(9;1.9e-09)|all cancers(9;1.22e-08)|BRCA - Breast invasive adenocarcinoma(10;8.86e-06)|OV - Ovarian serous cystadenocarcinoma(5;0.00559)			TCGGCTGCCTCCAGCCGCTTT	0.642		NaN											0	0	0	1	0	13	36									
ADAMTS5	11096	broad.mit.edu	37	21	28302318	28302318	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr21:28302318C>T	uc002ymg.2	-	7	2841	c.2112G>A	c.(2110-2112)GTG>GTA	p.V704V		NM_007038	NP_008969	Q9UNA0	ATS5_HUMAN	ADAM metallopeptidase with thrombospondin type 1	704	Cys-rich.				proteolysis	proteinaceous extracellular matrix	integrin binding|metalloendopeptidase activity|zinc ion binding			upper_aerodigestive_tract(2)|ovary(1)|pancreas(1)	4						AGCCAGTTCTCACACACTTCC	0.493		NaN											0	0	0	1	0	48	75									
IFNGR2	3460	broad.mit.edu	37	21	34804515	34804515	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr21:34804515C>G	uc002yrp.3	+	5	1241	c.593C>G	c.(592-594)TCA>TGA	p.S198*	IFNGR2_uc002yrq.3_Nonsense_Mutation_p.S217*|IFNGR2_uc010gma.2_Nonsense_Mutation_p.S119*|IFNGR2_uc002yrr.3_Nonsense_Mutation_p.S119*	NM_005534	NP_005525	P38484	INGR2_HUMAN	interferon gamma receptor 2 precursor	198	Extracellular (Potential).|Fibronectin type-III 2.				regulation of interferon-gamma-mediated signaling pathway|response to virus	endoplasmic reticulum|integral to plasma membrane	interferon-gamma receptor activity				0					Interferon gamma-1b(DB00033)	AACTCCATTTCATTGGATAAC	0.403		NaN											0	0	0	1	0	7	80									
CECR6	27439	broad.mit.edu	37	22	17601328	17601328	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr22:17601328C>T	uc002zmb.2	-	1	886	c.690G>A	c.(688-690)TGG>TGA	p.W230*	CECR6_uc002zma.2_Intron|uc002zmc.2_5'Flank	NM_031890	NP_114096	Q9BXQ6	CECR6_HUMAN	cat eye syndrome chromosome region, candidate 6	230											0		all_epithelial(15;0.0181)|Lung NSC(13;0.109)|all_lung(157;0.132)		Colorectal(9;0.221)		CAGTGGCGATCCAGGAGCACC	0.701		NaN											0	0	0	1	0	3	6									
NF2	4771	broad.mit.edu	37	22	30057257	30057257	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr22:30057257G>T	uc003age.3	+	8	1182	c.739G>T	c.(739-741)GAG>TAG	p.E247*	NF2_uc003afy.3_Nonsense_Mutation_p.E247*|NF2_uc003afz.3_Nonsense_Mutation_p.E164*|NF2_uc003agf.3_Nonsense_Mutation_p.E247*|NF2_uc003agb.3_Nonsense_Mutation_p.E170*|NF2_uc003agc.3_Nonsense_Mutation_p.E209*|NF2_uc003agd.3_RNA|NF2_uc003agg.3_Nonsense_Mutation_p.E247*|NF2_uc003aga.3_Nonsense_Mutation_p.E205*|NF2_uc003agh.3_Nonsense_Mutation_p.E206*|NF2_uc003agi.3_Nonsense_Mutation_p.E164*|NF2_uc003agj.3_Intron|NF2_uc003agk.3_Nonsense_Mutation_p.E209*	NM_000268	NP_000259	P35240	MERL_HUMAN	neurofibromin 2 isoform 1	247	FERM.				actin cytoskeleton organization|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of cell-cell adhesion|negative regulation of cell-matrix adhesion|negative regulation of DNA replication|negative regulation of tyrosine phosphorylation of Stat3 protein|negative regulation of tyrosine phosphorylation of Stat5 protein|positive regulation of stress fiber assembly|regulation of hippo signaling cascade|Schwann cell proliferation	cytoskeleton|early endosome|extrinsic to membrane|filopodium membrane|nucleolus|perinuclear region of cytoplasm|ruffle membrane	cytoskeletal protein binding|protein binding	p.?(1)|p.E247fs*4(1)|p.N226_E270del(1)|p.D245fs*31(1)|p.E247K(1)|p.L127_D382del(1)|p.L140_P252del(1)		meninges(372)|soft_tissue(284)|central_nervous_system(20)|kidney(10)|pleura(9)|skin(7)|large_intestine(5)|breast(5)|urinary_tract(3)|thyroid(2)|endometrium(2)|ovary(2)|lung(2)|stomach(2)|bone(2)|pituitary(1)	728						TTATGACCCTGAGAACAGACT	0.502		NaN	D|Mis|N|F|S|O		meningioma|acoustic neuroma|renal 	meningioma|acoustic neuroma			Neurofibromatosis_type_2				1	0	4.00102e-26	1	4.2383e-26	42	45									
SCUBE1	80274	broad.mit.edu	37	22	43627846	43627846	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr22:43627846C>T	uc003bdt.1	-	8	968	c.880G>A	c.(880-882)GAC>AAC	p.D294N		NM_173050	NP_766638	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	294	EGF-like 7; calcium-binding (Potential).				adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5		all_neural(38;0.0414)|Ovarian(80;0.07)				CAGAAGTGGTCGCAGCCTCCG	0.647		NaN									OREG0026615	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	1	0	4	16									
SLC6A11	6538	broad.mit.edu	37	3	10960123	10960123	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:10960123G>A	uc003bvz.2	+	8	1139	c.1105G>A	c.(1105-1107)GAG>AAG	p.E369K		NM_014229	NP_055044	P48066	S6A11_HUMAN	solute carrier family 6 (neurotransmitter	369					neurotransmitter secretion	integral to plasma membrane	gamma-aminobutyric acid:sodium symporter activity|neurotransmitter:sodium symporter activity			skin(3)|ovary(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.229)		ACCCATTGCTGAGGTGGCAGA	0.567		NaN											0	0	0	1	0	9	29									
GRIP2	80852	broad.mit.edu	37	3	14563188	14563188	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:14563188C>T	uc011avi.1	-	8	964	c.964G>A	c.(964-966)GAG>AAG	p.E322K	GRIP2_uc011avh.1_5'UTR|GRIP2_uc003byu.1_3'UTR|GRIP2_uc003byv.1_3'UTR	NM_001080423	NP_001073892	Q9C0E4	GRIP2_HUMAN	glutamate receptor interacting protein 2	225	PDZ 2.				synaptic transmission	cytosol|plasma membrane	protein binding			pancreas(1)	1						AAGAGTGCCTCGTGGCTGCAC	0.672		NaN											0	0	0	1	0	8	11									
SS18L2	51188	broad.mit.edu	37	3	42632421	42632421	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:42632421G>C	uc003clk.1	+	1	124	c.32G>C	c.(31-33)AGG>ACG	p.R11T	SEC22C_uc003cli.2_Intron	NM_016305	NP_057389	Q9UHA2	S18L2_HUMAN	synovial sarcoma translocation gene on	11											0				KIRC - Kidney renal clear cell carcinoma(284;0.214)		GACTGGCTGAGGGGCAAGGCG	0.572		NaN											0	0	0	1	0	12	49									
NKTR	4820	broad.mit.edu	37	3	42680599	42680599	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:42680599G>C	uc003clo.2	+	13	3550	c.3403G>C	c.(3403-3405)GAT>CAT	p.D1135H	NKTR_uc003clm.1_Missense_Mutation_p.D882H|NKTR_uc003clp.2_Missense_Mutation_p.D882H|NKTR_uc011azp.1_Intron|NKTR_uc003clq.1_Missense_Mutation_p.D1025H|NKTR_uc003clr.1_Missense_Mutation_p.D882H|NKTR_uc003cls.2_Missense_Mutation_p.D835H	NM_005385	NP_005376	P30414	NKTR_HUMAN	natural killer-tumor recognition sequence	1135					protein folding	membrane	cyclosporin A binding|peptidyl-prolyl cis-trans isomerase activity			ovary(2)|skin(1)	3				KIRC - Kidney renal clear cell carcinoma(284;0.24)		CTGCACTCCTGATAGGAGTTC	0.448		NaN											0	0	0	1	0	26	55									
KBTBD5	131377	broad.mit.edu	37	3	42727254	42727254	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:42727254C>T	uc003clv.1	+	1	244	c.144C>T	c.(142-144)CGC>CGT	p.R48R		NM_152393	NP_689606	Q2TBA0	KBTB5_HUMAN	kelch repeat and BTB (POZ) domain containing 5	48	BTB.									ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.214)		CGTGCCATCGCCTGGTGCTGG	0.692		NaN											0	0	0	1	0	7	28									
ZNF445	353274	broad.mit.edu	37	3	44497005	44497005	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:44497005G>C	uc003cnf.2	-	3	385	c.37C>G	c.(37-39)CAG>GAG	p.Q13E	ZNF445_uc011azv.1_Missense_Mutation_p.Q13E|ZNF445_uc011azw.1_Missense_Mutation_p.Q13E	NM_181489	NP_852466	P59923	ZN445_HUMAN	zinc finger protein 445	13					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(197;0.0514)|Kidney(197;0.0646)		GACTGGGCCTGAGCTGGATAG	0.567		NaN											0	0	0	1	0	5	44									
ZNF197	10168	broad.mit.edu	37	3	44683588	44683588	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:44683588G>A	uc003cnm.2	+	6	1172	c.966G>A	c.(964-966)AAG>AAA	p.K322K	ZNF197_uc003cnn.2_Intron|ZNF197_uc003cno.2_Intron|ZNF197_uc003cnp.2_Intron	NM_006991	NP_008922	O14709	ZN197_HUMAN	zinc finger protein 197 isoform 1	322					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(3)|skin(1)	4				KIRC - Kidney renal clear cell carcinoma(197;0.0478)|Kidney(197;0.0598)		ATACAGTGAAGAAAGTTTCCC	0.443		NaN											0	0	0	1	0	21	43									
KLHL18	23276	broad.mit.edu	37	3	47385224	47385224	+	Silent	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:47385224G>C	uc003crd.2	+	10	1644	c.1518G>C	c.(1516-1518)CTG>CTC	p.L506L	KLHL18_uc011bav.1_Silent_p.L394L	NM_025010	NP_079286	O94889	KLH18_HUMAN	kelch-like 18	506	Kelch 5.										0		Acute lymphoblastic leukemia(5;0.164)		BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00645)|Kidney(197;0.00741)		AGTGGTGCCTGATTGTCCCCA	0.622		NaN											0	0	0	1	0	21	70									
CELSR3	1951	broad.mit.edu	37	3	48665891	48665891	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:48665891C>T	uc003cuf.1	-	52	11991	c.11991G>A	c.(11989-11991)CAG>CAA	p.Q3997Q	SLC26A6_uc003cug.2_Silent_p.Q571Q|SLC26A6_uc003cuh.2_Silent_p.Q592Q|SLC26A6_uc010hke.2_Silent_p.Q443Q|SLC26A6_uc003cuk.2_Silent_p.Q485Q|SLC26A6_uc003cui.2_Silent_p.Q592Q|SLC26A6_uc003cuj.2_Silent_p.Q592Q|SLC26A6_uc011bbp.1_Silent_p.Q556Q	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	Error:Variant_position_missing_in_Q9NYQ7_after_alignment					homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TCTCCTCTTTCTGCAGTTGCT	0.388		NaN											0	0	0	1	0	38	96									
RHOA	387	broad.mit.edu	37	3	49397643	49397643	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:49397643C>T	uc003cwu.2	-	5	857	c.581G>A	c.(580-582)TGA>TAA	p.*194*	RHOA_uc010hku.2_Silent_p.*113*|GPX1_uc011bcl.1_5'Flank|GPX1_uc011bcm.1_5'Flank	NM_001664	NP_001655	P61586	RHOA_HUMAN	ras homolog gene family, member A precursor	194					axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	AGCAAGGTTTCACAAGACAAG	0.403		NaN											0	0	0	1	0	36	92									
RHOA	387	broad.mit.edu	37	3	49397721	49397721	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:49397721C>G	uc003cwu.2	-	5	779	c.503G>C	c.(502-504)AGA>ACA	p.R168T	RHOA_uc010hku.2_Missense_Mutation_p.R87T|GPX1_uc011bcl.1_5'Flank|GPX1_uc011bcm.1_5'Flank	NM_001664	NP_001655	P61586	RHOA_HUMAN	ras homolog gene family, member A precursor	168					axon guidance|interspecies interaction between organisms|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of axonogenesis|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of neuron differentiation|positive regulation of NF-kappaB import into nucleus|positive regulation of stress fiber assembly|regulation of cell migration|regulation of small GTPase mediated signal transduction|Rho protein signal transduction|spindle assembly involved in mitosis	cytoskeleton|cytosol|plasma membrane	GTP binding|GTPase activity|myosin binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;8.58e-05)|Kidney(197;0.0023)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	Atorvastatin(DB01076)|Simvastatin(DB00641)	AAAAACCTCTCTCACTCCATC	0.493		NaN											0	0	0	1	0	40	104									
PCBP4	57060	broad.mit.edu	37	3	51994209	51994209	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:51994209C>T	uc003dcd.1	-	5	779	c.383G>A	c.(382-384)CGA>CAA	p.R128Q	PCBP4_uc003dcb.1_Missense_Mutation_p.R94Q|PCBP4_uc003dcc.1_Missense_Mutation_p.R94Q|PCBP4_uc003dce.1_Missense_Mutation_p.R128Q|PCBP4_uc003dcf.1_Missense_Mutation_p.R128Q|PCBP4_uc003dcg.1_Missense_Mutation_p.R94Q|PCBP4_uc003dch.1_Missense_Mutation_p.R128Q|PCBP4_uc003dci.1_Missense_Mutation_p.R51Q|PCBP4_uc003dcj.1_Missense_Mutation_p.R128Q|PCBP4_uc003dck.1_Missense_Mutation_p.R128Q|PCBP4_uc003dcl.1_Missense_Mutation_p.R128Q	NM_033010	NP_127503	P57723	PCBP4_HUMAN	poly(rC) binding protein 4 isoform c	128	KH 2.					cytoplasm|ribonucleoprotein complex	DNA binding|RNA binding				0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CCTCACCTCTCGGATCTCCTT	0.592		NaN											0	0	0	1	0	15	56									
PBRM1	55193	broad.mit.edu	37	3	52692314	52692314	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:52692314C>G	uc003des.2	-	5	558	c.546G>C	c.(544-546)TTG>TTC	p.L182F	PBRM1_uc003dex.2_RNA|PBRM1_uc003deq.2_Missense_Mutation_p.L182F|PBRM1_uc003der.2_Missense_Mutation_p.L182F|PBRM1_uc003det.2_Missense_Mutation_p.L182F|PBRM1_uc003deu.2_Missense_Mutation_p.L182F|PBRM1_uc003dev.2_RNA|PBRM1_uc003dew.2_Missense_Mutation_p.L182F|PBRM1_uc010hmk.1_Missense_Mutation_p.L182F|PBRM1_uc003dey.2_Missense_Mutation_p.L182F|PBRM1_uc003dez.1_Missense_Mutation_p.L182F|PBRM1_uc003dfb.1_Missense_Mutation_p.L80F	NM_181042	NP_060635	Q86U86	PB1_HUMAN	polybromo 1 isoform 4	182					chromatin remodeling|mitosis|negative regulation of cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear chromosome	chromatin binding|DNA binding|protein binding			kidney(136)|breast(4)	140				BRCA - Breast invasive adenocarcinoma(193;1.8e-05)|Kidney(197;0.00105)|KIRC - Kidney renal clear cell carcinoma(197;0.00122)|OV - Ovarian serous cystadenocarcinoma(275;0.0613)		GGATCTCCTTCAAGTAAGCTG	0.373		NaN	Mis|N|F|S|D|O		clear cell renal carcinoma|breast								0	0	0	1	0	4	51									
ITIH4	3700	broad.mit.edu	37	3	52858879	52858879	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:52858879C>T	uc003dfz.2	-	7	891	c.855G>A	c.(853-855)ATG>ATA	p.M285I	ITIH4_uc011bel.1_Missense_Mutation_p.M15I|ITIH4_uc003dfy.2_Missense_Mutation_p.M149I|ITIH4_uc011bem.1_Missense_Mutation_p.M285I|ITIH4_uc011ben.1_Missense_Mutation_p.M285I	NM_002218	NP_002209	Q14624	ITIH4_HUMAN	inter-alpha (globulin) inhibitor H4	285	VWFA.				acute-phase response|hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		TCCTGCCACTCATGGAGCCGC	0.572		NaN											0	0	0	1	0	37	71									
PRKCD	5580	broad.mit.edu	37	3	53215603	53215603	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:53215603G>T	uc003dgl.2	+	6	873	c.520G>T	c.(520-522)GTG>TTG	p.V174L	PRKCD_uc003dgm.2_Missense_Mutation_p.V174L|PRKCD_uc003dgn.2_Missense_Mutation_p.V174L|PRKCD_uc010hmt.1_5'Flank	NM_006254	NP_006245	Q05655	KPCD_HUMAN	protein kinase C, delta	174	Phorbol-ester/DAG-type 1.				activation of phospholipase C activity|cellular component disassembly involved in apoptosis|cellular senescence|interferon-gamma-mediated signaling pathway|intracellular signal transduction|mRNA metabolic process|negative regulation of insulin receptor signaling pathway|negative regulation of MAP kinase activity|negative regulation of peptidyl-tyrosine phosphorylation|negative regulation of protein binding|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of ceramide biosynthetic process|positive regulation of glucosylceramide catabolic process|positive regulation of protein dephosphorylation|positive regulation of sphingomyelin catabolic process|protein stabilization|regulation of receptor activity|termination of signal transduction	cytosol|endoplasmic reticulum|nucleoplasm	ATP binding|calcium-independent protein kinase C activity|enzyme activator activity|enzyme binding|insulin receptor substrate binding|metal ion binding|protein C-terminus binding			central_nervous_system(4)|lung(3)|stomach(1)|skin(1)	9		Ovarian(412;0.0728)		OV - Ovarian serous cystadenocarcinoma(275;3.58e-08)|BRCA - Breast invasive adenocarcinoma(193;0.000142)|Kidney(197;0.00153)|KIRC - Kidney renal clear cell carcinoma(197;0.00173)		CTTCTGTTCTGTGTGCAAAGA	0.567		NaN											1	0	5.3912e-06	1	5.48653e-06	19	59									
DCBLD2	131566	broad.mit.edu	37	3	98538214	98538214	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:98538214G>A	uc003dtd.2	-	8	1282	c.919C>T	c.(919-921)CAA>TAA	p.Q307*	DCBLD2_uc003dte.2_Nonsense_Mutation_p.Q307*	NM_080927	NP_563615	Q96PD2	DCBD2_HUMAN	discoidin, CUB and LCCL domain containing 2	307	Extracellular (Potential).|F5/8 type C.				cell adhesion|intracellular receptor mediated signaling pathway|negative regulation of cell growth|wound healing	cell surface|integral to plasma membrane				ovary(2)|central_nervous_system(1)	3						GCTGTTATTTGAGGATCCGCG	0.448		NaN											0	0	0	1	0	14	21									
CEP97	79598	broad.mit.edu	37	3	101476575	101476575	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:101476575G>A	uc003dvk.1	+	9	1152	c.1125G>A	c.(1123-1125)ACG>ACA	p.T375T	CEP97_uc010hpm.1_Silent_p.T341T|CEP97_uc011bhf.1_Intron|CEP97_uc003dvl.1_Silent_p.T71T|CEP97_uc003dvm.1_Silent_p.T213T	NM_024548	NP_078824	Q8IW35	CEP97_HUMAN	centrosomal protein 97kDa	375	CEP110 binding.					centrosome|nucleus	protein binding			ovary(2)	2						TACACACTACGAGATATTCTC	0.398		NaN											0	0	0	1	0	21	62									
WDR52	55779	broad.mit.edu	37	3	113098284	113098284	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:113098284G>A	uc003eae.1	-	17	2213	c.2167C>T	c.(2167-2169)CAG>TAG	p.Q723*		NM_018338	NP_060808	Q96MT7	WDR52_HUMAN	WD repeat domain 52 isoform 2	723	Glu-rich.									central_nervous_system(1)	1						tcctcctcctGAAATTCTTTT	0.333		NaN											0	0	0	1	0	29	72									
IGSF11	152404	broad.mit.edu	37	3	118647366	118647366	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:118647366G>A	uc003ebw.2	-	3	661	c.414C>T	c.(412-414)CTC>CTT	p.L138L	IGSF11_uc011biv.1_Silent_p.L138L|IGSF11_uc003ebx.2_Silent_p.L138L|IGSF11_uc003eby.2_Silent_p.L137L|IGSF11_uc003ebz.2_Silent_p.L137L|IGSF11_uc010hqs.2_Silent_p.L137L	NM_001015887	NP_001015887	Q5DX21	IGS11_HUMAN	immunoglobulin superfamily, member 11 isoform b	138	Extracellular (Potential).				cell adhesion|regulation of growth	integral to membrane|plasma membrane	receptor activity				0						CTAACACTGTGAGACCGGTGA	0.493		NaN											0	0	0	1	0	12	42									
GOLGB1	2804	broad.mit.edu	37	3	121414111	121414111	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:121414111C>T	uc003eei.3	-	13	5370	c.5244G>A	c.(5242-5244)GAG>GAA	p.E1748E	GOLGB1_uc010hrc.2_Silent_p.E1753E|GOLGB1_uc003eej.3_Silent_p.E1714E|GOLGB1_uc011bjm.1_Silent_p.E1634E|GOLGB1_uc010hrd.1_Silent_p.E1712E	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	1748	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		GAGAGTCTTTCTCAGACATTA	0.378		NaN											0	0	0	1	0	42	99									
ALG1L	200810	broad.mit.edu	37	3	125649405	125649405	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:125649405G>C	uc003eig.1	-	5	507	c.343C>G	c.(343-345)CTG>GTG	p.L115V		NM_001015050	NP_001015050	Q6GMV1	ALG1L_HUMAN	asparagine-linked glycosylation 1-like	115							transferase activity, transferring glycosyl groups				0						GCTACCTGCAGAGCTGCCAGT	0.582		NaN											0	0	0	1	0	17	33									
TMCC1	23023	broad.mit.edu	37	3	129373852	129373852	+	Nonsense_Mutation	SNP	T	T	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:129373852T>A	uc003emz.3	-	6	2107	c.1606A>T	c.(1606-1608)AAA>TAA	p.K536*	TMCC1_uc003emy.3_Nonsense_Mutation_p.K212*|TMCC1_uc011blc.1_Nonsense_Mutation_p.K357*|TMCC1_uc010htg.2_Nonsense_Mutation_p.K422*	NM_001017395	NP_001017395	O94876	TMCC1_HUMAN	transmembrane and coiled-coil domain family 1	536	Potential.					integral to membrane				skin(1)	1						TACGCGATTTTTTCTTCCATG	0.423		NaN											0	0	0	1	0	23	70									
WWTR1	25937	broad.mit.edu	37	3	149260194	149260194	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:149260194C>G	uc003exe.2	-	3	715	c.699G>C	c.(697-699)CAG>CAC	p.Q233H	WWTR1_uc003exf.2_Missense_Mutation_p.Q233H|WWTR1_uc011bns.1_Missense_Mutation_p.Q233H|WWTR1_uc003exh.2_Missense_Mutation_p.Q233H	NM_015472	NP_056287	Q9GZV5	WWTR1_HUMAN	WW domain containing transcription regulator 1	233	Potential.|Gln-rich.				hippo signaling cascade|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of protein kinase activity|negative regulation of protein phosphorylation|positive regulation of cell proliferation|positive regulation of epithelial to mesenchymal transition|regulation of SMAD protein import into nucleus|stem cell division|transcription, DNA-dependent	cytoplasm	transcription coactivator activity			breast(3)|skin(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			GCCGCAGTTTCTGCTGCTGCT	0.577		NaN											0	0	0	1	0	8	40									
IGSF10	285313	broad.mit.edu	37	3	151163897	151163897	+	Missense_Mutation	SNP	A	A	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:151163897A>T	uc011bod.1	-	4	3872	c.3872T>A	c.(3871-3873)TTC>TAC	p.F1291Y		NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	1291					cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			AAGGGGTGGGAAGGGAAGCTC	0.433		NaN											0	0	0	1	0	53	124									
SGEF	26084	broad.mit.edu	37	3	153870637	153870637	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:153870637C>G	uc011bog.1	+	6	1614	c.1403C>G	c.(1402-1404)TCT>TGT	p.S468C	SGEF_uc011boh.1_Missense_Mutation_p.S468C	NM_015595	NP_056410	Q96DR7	ARHGQ_HUMAN	Src homology 3 domain-containing guanine	468	DH.				regulation of Rho protein signal transduction	intracellular|ruffle	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TTTAAAAATTCTAAAGAACTG	0.363		NaN											0	0	0	1	0	5	8									
PIK3CA	5290	broad.mit.edu	37	3	178936091	178936091	+	Missense_Mutation	SNP	G	G	A	rs104886003		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:178936091G>A	uc003fjk.2	+	10	1790	c.1633G>A	c.(1633-1635)GAG>AAG	p.E545K		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	545	PI3K helical.		E -> G (in KERSEB).|E -> A (in cancer).|E -> K (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; occurs in the interface between the PI3K helical domain and the nSH2 (N-terminal SH2) region of the p85 regulatory subunit and may reduce the inhibitory effect of p85; requires interaction with RAS to induce cellular transformation; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.E545K(735)|p.E545A(75)|p.E545G(55)|p.E545?(19)|p.E545D(15)|p.E545Q(12)|p.E545V(4)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			TGAAATCACTGAGCAGGAGAA	0.353	E545K(RERFLCSQ1_LUNG)|E545K(KYSE510_OESOPHAGUS)|E545K(NCIH508_LARGE_INTESTINE)|E545K(HCC202_BREAST)|E545K(BFTC909_KIDNEY)|E545K(HCT15_LARGE_INTESTINE)|E545K(NCIH596_LUNG)|E545K(L363_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|E545K(DLD1_LARGE_INTESTINE)|E545K(ESS1_ENDOMETRIUM)|E545K(MDAMB361_BREAST)|E545K(MKN1_STOMACH)|E545K(MCF7_BREAST)|E545K(NCIH460_LUNG)|E545K(TCCSUP_URINARY_TRACT)|E545K(HSC4_UPPER_AERODIGESTIVE_TRACT)|E545K(BC3C_URINARY_TRACT)|E545K(HUH28_BILIARY_TRACT)|E545K(HT1197_URINARY_TRACT)|E545K(TE5_OESOPHAGUS)	57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			0	0	0	1	0	6	50									
CHRD	8646	broad.mit.edu	37	3	184103022	184103022	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr3:184103022C>T	uc003fov.2	+	14	2060	c.1814C>T	c.(1813-1815)TCA>TTA	p.S605L	CHRD_uc003fow.2_Missense_Mutation_p.S235L|CHRD_uc003fox.2_Missense_Mutation_p.S605L|CHRD_uc003foy.2_Missense_Mutation_p.S235L|CHRD_uc010hyc.2_Missense_Mutation_p.S195L|CHRD_uc011brr.1_Missense_Mutation_p.S235L	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	605	CHRD 4.				BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TTCTATGGCTCAGAGGTAAGG	0.582		NaN											0	0	0	1	0	18	62									
WHSC1	7468	broad.mit.edu	37	4	1977056	1977056	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:1977056C>T	uc003gdz.3	+	20	3726	c.3550C>T	c.(3550-3552)CTG>TTG	p.L1184L	WHSC1_uc003geb.3_Silent_p.L1184L|WHSC1_uc003gec.3_Silent_p.L1184L|WHSC1_uc003ged.3_Silent_p.L1184L|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gei.3_Silent_p.L403L|WHSC1_uc011bvh.1_Silent_p.L245L|WHSC1_uc010icf.2_Silent_p.L532L	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	1184	SET.				anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		CCTCGATTGTCTGGGCAATGA	0.532		NaN	T	IGH@	MM								0	0	0	1	0	18	24									
WHSC2	7469	broad.mit.edu	37	4	1991499	1991499	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:1991499C>T	uc003gem.2	-	3	753	c.513G>A	c.(511-513)GTG>GTA	p.V171V	WHSC2_uc003gel.2_Silent_p.V85V|WHSC2_uc003gen.2_Silent_p.V25V	NM_005663	NP_005654	Q9H3P2	NELFA_HUMAN	Wolf-Hirschhorn syndrome candidate 2 protein	160					multicellular organismal development|positive regulation of viral transcription|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm				skin(1)	1			OV - Ovarian serous cystadenocarcinoma(23;0.0155)			GAAAATGCTTCACCGGGGGAG	0.612		NaN											0	0	0	1	0	50	94									
HAUS3	79441	broad.mit.edu	37	4	2238161	2238161	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:2238161C>G	uc003ges.1	-	4	1602	c.1372G>C	c.(1372-1374)GAG>CAG	p.E458Q	POLN_uc011bvi.1_Intron|HAUS3_uc011bvj.1_Missense_Mutation_p.E458Q|HAUS3_uc003get.1_Missense_Mutation_p.E458Q	NM_024511	NP_078787	Q68CZ6	HAUS3_HUMAN	HAUS augmin-like complex, subunit 3	458	Potential.				cell division|centrosome organization|mitosis|spindle assembly	centrosome|HAUS complex|microtubule|spindle				large_intestine(2)|breast(2)	4						TTCTTATTCTCTCCCTCCAAA	0.313		NaN											0	0	0	1	0	22	33									
ZBTB49	166793	broad.mit.edu	37	4	4322918	4322918	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:4322918G>A	uc003ghu.2	+	8	2348	c.2173G>A	c.(2173-2175)GAC>AAC	p.D725N	uc003ghw.2_5'Flank|ZBTB49_uc003ghv.2_Missense_Mutation_p.D208N|ZBTB49_uc010icy.2_RNA|ZBTB49_uc010icz.2_Missense_Mutation_p.D303N	NM_145291	NP_660334	Q6ZSB9	ZBT49_HUMAN	zinc finger protein 509	725					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2						CCACGGCGGTGACCCCCTGGG	0.587		NaN											0	0	0	1	0	12	15									
MRFAP1L1	114932	broad.mit.edu	37	4	6711276	6711276	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:6711276G>A	uc003gjn.2	-	1	321	c.81C>T	c.(79-81)TTC>TTT	p.F27F	MRFAP1L1_uc003gjo.2_Silent_p.F27F	NM_203462	NP_982287	Q96HT8	MR1L1_HUMAN	Morf4 family associated protein 1-like 1	27											0						CCGGGAGCAGGAACTGCTCGA	0.632		NaN											0	0	0	1	0	21	32									
TBC1D14	57533	broad.mit.edu	37	4	7016174	7016174	+	Splice_Site	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:7016174G>A	uc011bwg.1	+	12	1727	c.1648_splice	c.e12-1	p.M550_splice	TBC1D14_uc003gjs.3_Splice_Site_p.M550_splice|TBC1D14_uc010idh.2_Splice_Site_p.M270_splice|TBC1D14_uc011bwh.1_Splice_Site_p.M197_splice|TBC1D14_uc003gju.3_Splice_Site_p.M41_splice	NM_001113361	NP_001106832	Q9P2M4	TBC14_HUMAN	TBC1 domain family, member 14 isoform a							intracellular	Rab GTPase activator activity			ovary(1)|pancreas(1)	2						TATCTCCCTAGATGTTGACTT	0.299		NaN											0	0	0	1	0	4	7									
UGT2B10	7365	broad.mit.edu	37	4	69870721	69870721	+	Silent	SNP	A	A	G	rs111542944		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:69870721A>G	uc011cao.1	-	9	1465	c.1329T>C	c.(1327-1329)CAT>CAC	p.H443H	UGT2B10_uc011can.1_Silent_p.H359H			P36537	UDB10_HUMAN	RecName: Full=UDP-glucuronosyltransferase 2B28;          Short=UDPGT 2B28;          EC=2.4.1.17; Flags: Precursor;	480					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						AGGTGAGGTCATGGGCTGCAA	0.478		NaN											0	0	0	1	0	6	96									
FRAS1	80144	broad.mit.edu	37	4	79229280	79229280	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:79229280G>C	uc003hlb.2	+	15	2035	c.1595G>C	c.(1594-1596)AGA>ACA	p.R532T	FRAS1_uc003hkw.2_Missense_Mutation_p.R532T|FRAS1_uc003hky.1_Missense_Mutation_p.R236T|FRAS1_uc003hkz.2_Missense_Mutation_p.R236T|FRAS1_uc003hla.1_Missense_Mutation_p.R43T	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	532	FU 3.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						TTGGCCTGCAGAGATCCCCTC	0.577		NaN											0	0	0	1	0	5	11									
NUDT6	11162	broad.mit.edu	37	4	123814162	123814162	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:123814162C>T	uc003iew.2	-	5	804	c.772G>A	c.(772-774)GAA>AAA	p.E258K	FGF2_uc003iev.1_3'UTR|NUDT6_uc003iex.2_Missense_Mutation_p.E89K	NM_007083	NP_009014	P53370	NUDT6_HUMAN	nudix-type motif 6 isoform a	258	Nudix hydrolase.			KTEN -> RTKH (in Ref. 4; AAA67062).		mitochondrion|nucleus	growth factor activity|hydrolase activity				0						GTTGTATTTTCAGTCTTCGCC	0.448		NaN											0	0	0	1	0	8	69									
ODZ3	55714	broad.mit.edu	37	4	183714402	183714402	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:183714402G>A	uc003ivd.1	+	25	6614	c.6577G>A	c.(6577-6579)GAA>AAA	p.E2193K		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	2193	Extracellular (Potential).|YD 20.				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		TCGGTTGGATGAAGATGGTTT	0.483		NaN											0	0	0	1	0	20	41									
SNX25	83891	broad.mit.edu	37	4	186185662	186185662	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:186185662C>G	uc003ixh.2	+	4	499	c.310C>G	c.(310-312)CTA>GTA	p.L104V		NM_031953	NP_114159	Q9H3E2	SNX25_HUMAN	sorting nexin 25	104	PXA.				cell communication|protein transport	endosome membrane	phosphatidylinositol binding|signal transducer activity			ovary(2)|breast(2)|pancreas(1)	5		all_lung(41;1.03e-13)|Lung NSC(41;2.5e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00886)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;2.13e-24)|Epithelial(43;6.15e-22)|OV - Ovarian serous cystadenocarcinoma(60;5.6e-11)|BRCA - Breast invasive adenocarcinoma(30;0.00013)|Colorectal(24;0.000165)|GBM - Glioblastoma multiforme(59;0.000357)|COAD - Colon adenocarcinoma(29;0.000887)|STAD - Stomach adenocarcinoma(60;0.00118)|LUSC - Lung squamous cell carcinoma(40;0.0129)|READ - Rectum adenocarcinoma(43;0.228)		AGTAAGATTTCTACAAACGTG	0.413		NaN											0	0	0	1	0	28	42									
TLR3	7098	broad.mit.edu	37	4	186997899	186997899	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr4:186997899G>A	uc003iyq.2	+	2	227	c.126G>A	c.(124-126)TTG>TTA	p.L42L		NM_003265	NP_003256	O15455	TLR3_HUMAN	toll-like receptor 3 precursor	42	LRRNT.|Lumenal (Potential).				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			ovary(2)|prostate(1)|lung(1)|breast(1)	5		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		ACCTGAAGTTGACTCAGGTAC	0.498		NaN											0	0	0	1	0	4	47									
IRX1	79192	broad.mit.edu	37	5	3600251	3600251	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:3600251C>T	uc003jde.2	+	2	1241	c.1189C>T	c.(1189-1191)CCC>TCC	p.P397S		NM_024337	NP_077313	P78414	IRX1_HUMAN	iroquois homeobox protein 1	397						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|pancreas(1)	2						CGTTGGCGCTCCCCACGCCGC	0.662		NaN											0	0	0	1	0	7	39									
ADCY2	108	broad.mit.edu	37	5	7414870	7414870	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:7414870C>T	uc003jdz.1	+	2	462	c.395C>T	c.(394-396)TCT>TTT	p.S132F		NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	132					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						GGCACCGTCTCTCCCTGGGAC	0.423		NaN											0	0	0	1	0	10	78									
MTRR	4552	broad.mit.edu	37	5	7878257	7878257	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:7878257G>A	uc003jed.2	+	5	713	c.683G>A	c.(682-684)AGA>AAA	p.R228K	MTRR_uc010itn.1_RNA|MTRR_uc003jee.3_Missense_Mutation_p.R201K|MTRR_uc003jef.3_RNA|MTRR_uc003jeg.3_RNA|MTRR_uc010ito.2_RNA	NM_024010	NP_076915	Q9UBK8	MTRR_HUMAN	methionine synthase reductase isoform 2	228	Hinge.				methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			ovary(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	GATTCAGGAAGAAAGGATTCT	0.468		NaN											0	0	0	1	0	9	177									
MTRR	4552	broad.mit.edu	37	5	7878391	7878391	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:7878391C>T	uc003jed.2	+	5	847	c.817C>T	c.(817-819)CCC>TCC	p.P273S	MTRR_uc010itn.1_RNA|MTRR_uc003jee.3_Missense_Mutation_p.P246S|MTRR_uc003jef.3_RNA|MTRR_uc003jeg.3_RNA|MTRR_uc010ito.2_RNA	NM_024010	NP_076915	Q9UBK8	MTRR_HUMAN	methionine synthase reductase isoform 2	273	Hinge.				methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			ovary(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	TCCTGGTTTACCCCCAGAATA	0.423		NaN											0	0	0	1	0	41	242									
MTRR	4552	broad.mit.edu	37	5	7892992	7892992	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:7892992C>T	uc003jed.2	+	11	1634	c.1604C>T	c.(1603-1605)TCC>TTC	p.S535F	MTRR_uc003jee.3_Missense_Mutation_p.S508F|MTRR_uc003jef.3_RNA|MTRR_uc003jeg.3_RNA|MTRR_uc010ito.2_RNA	NM_024010	NP_076915	Q9UBK8	MTRR_HUMAN	methionine synthase reductase isoform 2	535	FAD-binding FR-type.				methionine biosynthetic process	cytosol	[methionine synthase] reductase activity|flavin adenine dinucleotide binding|FMN binding|iron ion binding|NADP binding			ovary(1)	1					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)|L-Methionine(DB00134)	ATACATGCATCCCATGAAGAC	0.448		NaN											0	0	0	1	0	21	71									
FAM173B	134145	broad.mit.edu	37	5	10235356	10235356	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:10235356G>T	uc003jeo.2	-	4	491	c.462C>A	c.(460-462)TAC>TAA	p.Y154*	FAM173B_uc003jep.2_RNA|FAM173B_uc010itr.2_Intron	NM_199133	NP_954584	Q6P4H8	F173B_HUMAN	hypothetical protein LOC134145	154						integral to membrane				kidney(1)|central_nervous_system(1)	2						CAACGTTCGAGTACTGCGAAA	0.428		NaN											1	0	0.000157383	1	0.000159539	6	42									
CDH9	1007	broad.mit.edu	37	5	26890543	26890543	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:26890543C>T	uc003jgs.1	-	8	1553	c.1384G>A	c.(1384-1386)GAA>AAA	p.E462K	CDH9_uc011cnv.1_Missense_Mutation_p.E55K	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	462	Extracellular (Potential).|Cadherin 4.				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						TTACTTATTTCTGTGGCTGTA	0.393		NaN											0	0	0	1	0	21	126									
ADAMTS12	81792	broad.mit.edu	37	5	33596062	33596062	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:33596062G>T	uc003jia.1	-	17	2794	c.2631C>A	c.(2629-2631)TGC>TGA	p.C877*	ADAMTS12_uc010iuq.1_Nonsense_Mutation_p.C792*	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	877	TSP type-1 2.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						CCTTTTCATGGCACTTCTTCT	0.527		NaN								HNSCC(64;0.19)			1	0	2.94398e-08	1	3.05608e-08	17	112									
UGT3A1	133688	broad.mit.edu	37	5	35957426	35957426	+	Silent	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:35957426G>C	uc003jjv.1	-	5	1096	c.939C>G	c.(937-939)CTC>CTG	p.L313L	UGT3A1_uc003jjw.1_RNA|UGT3A1_uc011coq.1_Silent_p.L313L|UGT3A1_uc011cor.1_Silent_p.L279L	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	313	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GCATCTTCTTGAGGACTTCCT	0.493		NaN											0	0	0	1	0	6	85									
RANBP3L	202151	broad.mit.edu	37	5	36265595	36265595	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:36265595G>C	uc003jkh.2	-	5	789	c.296C>G	c.(295-297)TCA>TGA	p.S99*	RANBP3L_uc011cow.1_Nonsense_Mutation_p.S124*	NM_145000	NP_659437	Q86VV4	RNB3L_HUMAN	RAN binding protein 3-like isoform 2	99					intracellular transport					ovary(1)	1	all_lung(31;4.52e-05)		Epithelial(62;0.0543)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|all cancers(62;0.149)|Colorectal(62;0.202)			CACAAGAGCTGATGTCATAAA	0.299		NaN											0	0	0	1	0	15	75									
NUP155	9631	broad.mit.edu	37	5	37371053	37371053	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:37371053C>T	uc003jku.1	-	1	145	c.27G>A	c.(25-27)GCG>GCA	p.A9A	NUP155_uc003jkt.1_5'Flank|NUP155_uc010iuz.1_Silent_p.A9A	NM_153485	NP_705618	O75694	NU155_HUMAN	nucleoporin 155kDa isoform 1	9					carbohydrate metabolic process|glucose transport|mRNA transport|nucleocytoplasmic transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear membrane|nuclear pore	protein binding|structural constituent of nuclear pore|transporter activity			ovary(1)	1	all_lung(31;0.000137)		COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			AGGCCGGCATCGCCGCGCCCA	0.537		NaN											0	0	0	1	0	17	80									
PLCXD3	345557	broad.mit.edu	37	5	41382631	41382631	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:41382631G>A	uc003jmm.1	-	2	211	c.109C>T	c.(109-111)CAT>TAT	p.H37Y		NM_001005473	NP_001005473	Q63HM9	PLCX3_HUMAN	phosphatidylinositol-specific phospholipase C, X	37	PI-PLC X-box.	By similarity.			intracellular signal transduction|lipid catabolic process		phospholipase C activity|signal transducer activity			skin(2)|urinary_tract(1)|ovary(1)|lung(1)|central_nervous_system(1)	6						AAGGAATCATGAGACCCTAGG	0.458		NaN											0	0	0	1	0	36	47									
PARP8	79668	broad.mit.edu	37	5	50091139	50091139	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:50091139C>T	uc003jon.3	+	13	1498	c.1316C>T	c.(1315-1317)TCA>TTA	p.S439L	PARP8_uc011cpz.1_Missense_Mutation_p.S331L|PARP8_uc003joo.2_Missense_Mutation_p.S439L|PARP8_uc003jop.2_Missense_Mutation_p.S439L	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	439						intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)				GCCCCCAAGTCATCCAAAACT	0.438		NaN											0	0	0	1	0	22	50									
RNF180	285671	broad.mit.edu	37	5	63510308	63510308	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:63510308G>A	uc003jti.2	+	4	1265	c.1155G>A	c.(1153-1155)AGG>AGA	p.R385R	RNF180_uc003jth.3_Silent_p.R385R|RNF180_uc010iws.2_Intron	NM_001113561	NP_001107033	Q86T96	RN180_HUMAN	ring finger protein 180 isoform 1	385	Interaction with ZIC2 (By similarity).|Cytoplasmic (Potential).					integral to membrane|nuclear envelope	zinc ion binding				0		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0848)|Colorectal(97;0.234)		Lung(70;0.114)		ATCTAAGAAGGAAACAACGAA	0.393		NaN											0	0	0	1	0	16	55									
AP3B1	8546	broad.mit.edu	37	5	77409639	77409639	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:77409639C>G	uc003kfj.2	-	19	2311	c.2186G>C	c.(2185-2187)GGA>GCA	p.G729A		NM_003664	NP_003655	O00203	AP3B1_HUMAN	adaptor-related protein complex 3, beta 1	729	Glu/Ser-rich.				endocytosis|melanosome organization	clathrin coated vesicle membrane|Golgi apparatus|membrane coat	protein phosphatase binding|protein transporter activity			central_nervous_system(1)	1		all_lung(232;0.000397)|Lung NSC(167;0.00106)|Ovarian(174;0.0105)|Prostate(461;0.215)		OV - Ovarian serous cystadenocarcinoma(54;8.23e-47)|Epithelial(54;2.74e-41)|all cancers(79;4.8e-36)		TGACTCCCGTCCACTCTCACT	0.453		NaN							Hermansky-Pudlak_syndrome				0	0	0	1	0	10	92									
PAPD4	167153	broad.mit.edu	37	5	78944941	78944941	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:78944941C>T	uc010jae.1	+	11	1373	c.955C>T	c.(955-957)CAG>TAG	p.Q319*	PAPD4_uc003kgb.2_Nonsense_Mutation_p.Q319*|PAPD4_uc010jaf.1_Nonsense_Mutation_p.Q319*|PAPD4_uc003kga.2_Nonsense_Mutation_p.Q315*|PAPD4_uc003kfz.2_Intron	NM_001114393	NP_001107865	Q6PIY7	GLD2_HUMAN	PAP associated domain containing 4	319					histone mRNA catabolic process|mRNA processing|RNA polyadenylation	cytoplasm	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity			ovary(1)	1		Lung NSC(167;0.00293)|all_lung(232;0.00323)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;8.61e-47)|Epithelial(54;1.32e-41)|all cancers(79;2.45e-36)		AAGTCACCATCAGATAAATGA	0.358		NaN											0	0	0	1	0	10	26									
ZFYVE16	9765	broad.mit.edu	37	5	79733262	79733262	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:79733262C>A	uc003kgr.3	+	4	1060	c.758C>A	c.(757-759)TCC>TAC	p.S253Y	ZFYVE16_uc010jak.1_Missense_Mutation_p.S253Y|ZFYVE16_uc003kgp.2_Missense_Mutation_p.S253Y|ZFYVE16_uc003kgq.3_Missense_Mutation_p.S253Y|ZFYVE16_uc003kgs.3_Missense_Mutation_p.S253Y	NM_001105251	NP_001098721	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	253					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity				0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		CGACAAAGTTCCAAAATGTTT	0.343		NaN											1	0	2.27525e-19	1	2.39063e-19	26	67									
ZFYVE16	9765	broad.mit.edu	37	5	79734015	79734015	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:79734015C>G	uc003kgr.3	+	4	1813	c.1511C>G	c.(1510-1512)TCA>TGA	p.S504*	ZFYVE16_uc010jak.1_Nonsense_Mutation_p.S504*|ZFYVE16_uc003kgp.2_Nonsense_Mutation_p.S504*|ZFYVE16_uc003kgq.3_Nonsense_Mutation_p.S504*|ZFYVE16_uc003kgs.3_Nonsense_Mutation_p.S504*	NM_001105251	NP_001098721	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	504					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity				0		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		AATACTTTTTCAAGCAATGAT	0.403		NaN											0	0	0	1	0	26	53									
VCAN	1462	broad.mit.edu	37	5	82789485	82789485	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:82789485A>G	uc003kii.3	+	4	922	c.566A>G	c.(565-567)TAT>TGT	p.Y189C	VCAN_uc003kij.3_Missense_Mutation_p.Y189C|VCAN_uc010jau.2_Missense_Mutation_p.Y189C|VCAN_uc003kik.3_Missense_Mutation_p.Y189C|VCAN_uc003kih.3_Missense_Mutation_p.Y189C	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	189	Link 1.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TTTGCTGCCTATGAAGATGGA	0.522		NaN											0	0	0	1	0	30	79									
EDIL3	10085	broad.mit.edu	37	5	83239311	83239311	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:83239311C>T	uc003kio.1	-	11	1789	c.1370G>A	c.(1369-1371)AGA>AAA	p.R457K	EDIL3_uc003kip.1_Missense_Mutation_p.R447K	NM_005711	NP_005702	O43854	EDIL3_HUMAN	EGF-like repeats and discoidin I-like	457	F5/8 type C 2.				cell adhesion|multicellular organismal development	extracellular region	calcium ion binding|integrin binding			skin(2)	2		Lung NSC(167;0.000121)|all_lung(232;0.000154)|Ovarian(174;0.0425)		OV - Ovarian serous cystadenocarcinoma(54;4.3e-40)|Epithelial(54;4.79e-32)|all cancers(79;1.54e-26)		AGGAAGGATTCTTATGTGTCG	0.468		NaN											0	0	0	1	0	11	42									
SPATA9	83890	broad.mit.edu	37	5	95011140	95011140	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:95011140C>T	uc003klj.1	-	3	510	c.354G>A	c.(352-354)CCG>CCA	p.P118P	SPATA9_uc010jbh.1_RNA|SPATA9_uc003klh.1_RNA|SPATA9_uc003kli.1_Intron	NM_031952	NP_114158	Q9BWV2	SPAT9_HUMAN	spermatogenesis associated 9	118					cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane					0		all_cancers(142;1.28e-06)|all_epithelial(76;1.55e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)|Colorectal(57;0.0846)|Breast(839;0.198)		all cancers(79;8.91e-16)		GGGGTTGCCTCGGCGCATTAA	0.408		NaN											0	0	0	1	0	20	40									
RGMB	285704	broad.mit.edu	37	5	98129101	98129101	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:98129101G>A	uc003knc.2	+	5	1483	c.1081G>A	c.(1081-1083)GAA>AAA	p.E361K		NM_001012761	NP_001012779	Q6NW40	RGMB_HUMAN	RGM domain family, member B	320					axon guidance|BMP signaling pathway|cell adhesion|positive regulation of transcription, DNA-dependent	anchored to plasma membrane|ER-Golgi intermediate compartment|membrane raft	identical protein binding				0		all_cancers(142;2.76e-08)|all_epithelial(76;2.98e-11)|all_lung(232;0.000485)|Lung NSC(167;0.000693)|Prostate(80;0.000986)|Ovarian(225;0.024)|Colorectal(57;0.117)		COAD - Colon adenocarcinoma(37;0.0587)		CCCCCTGAGTGAACGCATCGA	0.637		NaN											0	0	0	1	0	4	20									
MARCH3	115123	broad.mit.edu	37	5	126214081	126214081	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:126214081C>T	uc003kuf.2	-	4	854	c.399G>A	c.(397-399)CTG>CTA	p.L133L		NM_178450	NP_848545	Q86UD3	MARH3_HUMAN	membrane-associated ring finger (C3HC4) 3	133					endocytosis	cytoplasmic vesicle membrane|early endosome membrane|integral to membrane|lysosome	ligase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		Prostate(80;0.0928)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	Epithelial(69;0.074)|OV - Ovarian serous cystadenocarcinoma(64;0.0793)		CAGGGTTTCTCAGCCACTGCC	0.547		NaN											0	0	0	1	0	4	10									
AFF4	27125	broad.mit.edu	37	5	132270153	132270153	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:132270153G>A	uc003kyd.2	-	3	1012	c.604C>T	c.(604-606)CAC>TAC	p.H202Y	AFF4_uc011cxk.1_5'UTR|AFF4_uc003kye.1_Missense_Mutation_p.H202Y|AFF4_uc003kyf.3_Missense_Mutation_p.H202Y	NM_014423	NP_055238	Q9UHB7	AFF4_HUMAN	ALL1 fused gene from 5q31	202	Ser-rich.				transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)|kidney(2)|skin(1)	5		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			TTGCTATGGTGATCATTCCCA	0.488		NaN											0	0	0	1	0	21	73									
PCDHB8	56128	broad.mit.edu	37	5	140558545	140558545	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:140558545C>T	uc011dai.1	+	1	1116	c.930C>T	c.(928-930)TTC>TTT	p.F310F	PCDHB16_uc003liv.2_5'Flank	NM_019120	NP_061993	Q9UN66	PCDB8_HUMAN	protocadherin beta 8 precursor	310	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(4)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AACTTGATTTCGAAAAATTTC	0.383		NaN											0	0	0	1	0	32	275									
SLC25A2	83884	broad.mit.edu	37	5	140682702	140682702	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:140682702C>T	uc003ljf.2	-	1	911	c.731G>A	c.(730-732)GGG>GAG	p.G244E		NM_031947	NP_114153	Q9BXI2	ORNT2_HUMAN	solute carrier family 25 member 2	244	Helical; Name=6; (Potential).|Solcar 3.				mitochondrial ornithine transport|urea cycle	integral to membrane|mitochondrial inner membrane	L-ornithine transmembrane transporter activity			ovary(1)	1		all_lung(500;0.000249)|Lung NSC(810;0.0011)|Ovarian(839;0.00556)|Breast(839;0.0173)|all_hematologic(541;0.152)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)	GBM - Glioblastoma multiforme(465;0.00204)	L-Ornithine(DB00129)	TGCCTGTTTCCCATACATGGA	0.403		NaN											0	0	0	1	0	23	51									
KCTD16	57528	broad.mit.edu	37	5	143853407	143853407	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:143853407C>G	uc003lnm.1	+	4	1646	c.1017C>G	c.(1015-1017)ATC>ATG	p.I339M	KCTD16_uc003lnn.1_Missense_Mutation_p.I339M	NM_020768	NP_065819	Q68DU8	KCD16_HUMAN	potassium channel tetramerisation domain	339						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(2)|ovary(1)|skin(1)	4		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			AGACCAACATCCAGACTCTGG	0.582		NaN											0	0	0	1	0	19	63									
FAT2	2196	broad.mit.edu	37	5	150924410	150924410	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:150924410G>T	uc003lue.3	-	9	6291	c.6278C>A	c.(6277-6279)TCT>TAT	p.S2093Y	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	2093	Extracellular (Potential).|Cadherin 18.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			ATCAGTGGCAGATACCTGAAA	0.443		NaN											1	0	8.16277e-20	1	8.59414e-20	36	100									
THG1L	54974	broad.mit.edu	37	5	157161651	157161651	+	Missense_Mutation	SNP	G	G	A	rs78234336		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:157161651G>A	uc003lxd.2	+	3	562	c.436G>A	c.(436-438)GAG>AAG	p.E146K	THG1L_uc011ddu.1_Intron	NM_017872	NP_060342	Q9NWX6	THG1_HUMAN	interphase cytoplasmic foci protein 45	146					protein homotetramerization|tRNA modification	mitochondrion	GTP binding|metal ion binding|tRNA guanylyltransferase activity				0	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GGATTACTTTGAGGACCAGCC	0.502		NaN											0	0	0	1	0	25	87									
ODZ2	57451	broad.mit.edu	37	5	167689355	167689355	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:167689355T>C	uc010jjd.2	+	29	7838	c.7838T>C	c.(7837-7839)GTG>GCG	p.V2613A	ODZ2_uc003lzr.3_Missense_Mutation_p.V2383A|ODZ2_uc003lzt.3_Missense_Mutation_p.V1986A|ODZ2_uc010jje.2_Missense_Mutation_p.V1877A	NM_001122679	NP_001116151			odz, odd Oz/ten-m homolog 2											ovary(6)|central_nervous_system(4)	10	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		CACTACTTTGTGAAGATTGGC	0.592		NaN											0	0	0	1	0	5	10									
UIMC1	51720	broad.mit.edu	37	5	176396246	176396246	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:176396246G>C	uc011dfp.1	-	6	677	c.510C>G	c.(508-510)ATC>ATG	p.I170M	UIMC1_uc003mfc.1_Missense_Mutation_p.I47M|UIMC1_uc003mfd.1_Intron|UIMC1_uc003mfg.1_Intron|UIMC1_uc003mff.1_Intron	NM_016290	NP_057374	Q96RL1	UIMC1_HUMAN	ubiquitin interaction motif containing 1	170	Necessary for interaction with NR6A1 N- terminus.				double-strand break repair|G2/M transition DNA damage checkpoint|histone H2A K63-linked deubiquitination|negative regulation of transcription, DNA-dependent|positive regulation of DNA repair|response to ionizing radiation|transcription, DNA-dependent	BRCA1-A complex	histone binding|K63-linked polyubiquitin binding			ovary(3)|skin(1)	4	all_cancers(89;7.96e-05)|Renal(175;0.000269)|Lung NSC(126;0.00476)|all_lung(126;0.00806)	Medulloblastoma(196;0.0145)|all_neural(177;0.0325)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			TTCCCTGACTGATATGTGAGC	0.483		NaN											0	0	0	1	0	9	107									
AGXT2L2	85007	broad.mit.edu	37	5	177658513	177658513	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:177658513C>G	uc003miz.2	-	2	323	c.71G>C	c.(70-72)AGA>ACA	p.R24T	AGXT2L2_uc003mjc.2_5'UTR|AGXT2L2_uc003mja.2_RNA|AGXT2L2_uc003mjb.2_5'UTR	NM_153373	NP_699204	Q8IUZ5	AT2L2_HUMAN	alanine-glyoxylate aminotransferase 2-like 2	24						mitochondrion	pyridoxal phosphate binding|transaminase activity			pancreas(1)	1	all_cancers(89;0.00185)|Renal(175;0.000269)|Lung NSC(126;0.00858)|all_lung(126;0.0139)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.181)|all cancers(165;0.235)	L-Alanine(DB00160)|Pyridoxal Phosphate(DB00114)	AAAAAAGAGTCTGCAGGAAGA	0.547		NaN											0	0	0	1	0	32	94									
C5orf45	51149	broad.mit.edu	37	5	179264605	179264605	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr5:179264605C>G	uc003mla.2	-	7	862	c.818G>C	c.(817-819)AGA>ACA	p.R273T	SQSTM1_uc011dgr.1_3'UTR|SQSTM1_uc011dgs.1_3'UTR|SQSTM1_uc003mkw.3_3'UTR|SQSTM1_uc003mkx.2_3'UTR|C5orf45_uc003mky.2_Intron|C5orf45_uc011dgt.1_Intron|C5orf45_uc011dgu.1_Intron|C5orf45_uc003mlc.2_Missense_Mutation_p.R218T|C5orf45_uc003mlb.2_Missense_Mutation_p.R139T	NM_016175	NP_057259	Q6NTE8	CE045_HUMAN	hypothetical protein LOC51149 isoform 1	273											0						GAGGCCTTCTCTTGAGGCCTG	0.632		NaN											0	0	0	1	0	31	64									
C6orf145	221749	broad.mit.edu	37	6	3723966	3723966	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:3723966C>G	uc003mvt.2	-	5	1064	c.583G>C	c.(583-585)GAG>CAG	p.E195Q		NM_183373	NP_899229	Q5TGL8	CF145_HUMAN	hypothetical protein LOC221749	195					cell communication		phosphatidylinositol binding			breast(1)	1	Ovarian(93;0.0925)	all_hematologic(90;0.108)				CTGCCATTCTCAAATCTGAAA	0.537		NaN											0	0	0	1	0	16	41									
KDM1B	221656	broad.mit.edu	37	6	18160153	18160153	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:18160153G>C	uc003ncn.1	+	3	268	c.27G>C	c.(25-27)AAG>AAC	p.K9N		NM_153042	NP_694587	Q8NB78	KDM1B_HUMAN	amine oxidase (flavin containing) domain 1	9					multicellular organismal development|regulation of DNA methylation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone demethylase activity (H3-dimethyl-K4 specific)|histone demethylase activity (H3-monomethyl-K4 specific)|oxidoreductase activity|zinc ion binding			skin(1)	1						GGAGGACAAAGAAAAAAGCAT	0.333		NaN											0	0	0	1	0	6	22									
HIST1H2AD	3013	broad.mit.edu	37	6	26199400	26199400	+	Silent	SNP	G	G	C	rs150465023		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:26199400G>C	uc003ngw.2	-	1	72	c.72C>G	c.(70-72)CTC>CTG	p.L24L	HIST1H3D_uc003ngv.2_5'UTR|HIST1H2BF_uc003ngx.2_5'Flank	NM_021065	NP_066409	P20671	H2A1D_HUMAN	histone cluster 1, H2ad	24					nucleosome assembly	nucleosome|nucleus	DNA binding				0		all_hematologic(11;0.196)				CAGGGAACTGGAGTCCGGCCC	0.612		NaN											0	0	0	1	0	17	31									
ZNF184	7738	broad.mit.edu	37	6	27419547	27419547	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:27419547C>T	uc003njj.2	-	5	2602	c.1791G>A	c.(1789-1791)CAG>CAA	p.Q597Q	ZNF184_uc010jqv.2_Silent_p.Q597Q|ZNF184_uc003nji.2_Silent_p.Q597Q	NM_007149	NP_009080	Q99676	ZN184_HUMAN	zinc finger protein 184	597	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GGTGTATGTTCTGGTTGAATG	0.433		NaN											0	0	0	1	0	29	69									
ZNF323	64288	broad.mit.edu	37	6	28295307	28295307	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:28295307G>A	uc003nla.2	-	3	785	c.385C>T	c.(385-387)CCA>TCA	p.P129S	ZNF323_uc003nld.2_Missense_Mutation_p.P129S|ZNF323_uc010jra.2_Missense_Mutation_p.P129S|ZNF323_uc003nlb.2_5'UTR|ZNF323_uc010jrb.2_5'UTR|ZNF323_uc003nlc.2_Missense_Mutation_p.P129S	NM_001135216	NP_001128688	Q96LW9	ZN323_HUMAN	zinc finger protein 323	129					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						TCATGGTCTGGAGCCTGAAGG	0.423		NaN											0	0	0	1	0	23	66									
HLA-E	3133	broad.mit.edu	37	6	30458229	30458229	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:30458229G>A	uc003nqg.2	+	3	585	c.547G>A	c.(547-549)GAC>AAC	p.D183N	HLA-E_uc011dmg.1_RNA|HLA-E_uc011dmh.1_Missense_Mutation_p.D224N	NM_005516	NP_005507	P13747	HLAE_HUMAN	major histocompatibility complex, class I, E	183	Extracellular (Potential).|Alpha-2.				antigen processing and presentation of peptide antigen via MHC class I|interferon-gamma-mediated signaling pathway|regulation of immune response|type I interferon-mediated signaling pathway	integral to membrane|MHC class I protein complex	MHC class I receptor activity			central_nervous_system(4)|ovary(1)	5						CTACCTGGAAGACACATGCGT	0.597		NaN											0	0	0	1	0	20	42									
BAT2	7916	broad.mit.edu	37	6	31599733	31599733	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:31599733G>A	uc003nvb.3	+	16	3532	c.3283G>A	c.(3283-3285)GAG>AAG	p.E1095K	BAT2_uc011dnv.1_Intron|BAT2_uc003nvc.3_Missense_Mutation_p.E1095K	NM_080686	NP_542417	P48634	PRC2A_HUMAN	HLA-B associated transcript-2	1095	4 X 57 AA type A repeats.					cytoplasm|nucleus	protein binding				0						TTCAGAGTATGAGGAAATCCC	0.637		NaN											0	0	0	1	0	5	25									
TNXB	7148	broad.mit.edu	37	6	32029210	32029210	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:32029210G>A	uc003nzl.2	-	21	7658	c.7456C>T	c.(7456-7458)CGG>TGG	p.R2486W		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2546	Fibronectin type-III 17.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						CCCACGCGCCGCCCCTCGTGG	0.647		NaN											0	0	0	1	0	37	84									
TNXB	7148	broad.mit.edu	37	6	32035515	32035515	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:32035515C>G	uc003nzl.2	-	18	6669	c.6467G>C	c.(6466-6468)GGG>GCG	p.G2156A		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2228	Fibronectin type-III 14.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						GTACTTGCGCCCAGGCTCCAG	0.677		NaN											0	0	0	1	0	15	49									
ATF6B	1388	broad.mit.edu	37	6	32085730	32085730	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:32085730C>T	uc003nzn.2	-	12	1363	c.1330G>A	c.(1330-1332)GAG>AAG	p.E444K	TNXB_uc010jts.1_5'Flank|ATF6B_uc003nzm.1_Missense_Mutation_p.E17K|ATF6B_uc003nzo.2_Missense_Mutation_p.E441K|ATF6B_uc003nzp.1_Missense_Mutation_p.E133K	NM_004381	NP_004372	Q99941	ATF6B_HUMAN	activating transcription factor 6 beta isoform	444	Lumenal (Potential).				response to unfolded protein|signal transduction	endoplasmic reticulum membrane|integral to membrane|nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						GGCTCTTGCTCTGAGAACCCC	0.602		NaN											0	0	0	1	0	13	19									
ITPR3	3710	broad.mit.edu	37	6	33648329	33648329	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:33648329C>G	uc011drk.1	+	33	4567	c.4348C>G	c.(4348-4350)CGG>GGG	p.R1450G		NM_002224	NP_002215	Q14573	ITPR3_HUMAN	inositol 1,4,5-triphosphate receptor, type 3	1450	Cytoplasmic (Potential).				activation of phospholipase C activity|calcium ion transport into cytosol|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|nerve growth factor receptor signaling pathway|platelet activation|protein heterooligomerization|protein homooligomerization|regulation of insulin secretion|response to calcium ion	apical part of cell|brush border|endoplasmic reticulum membrane|integral to plasma membrane|myelin sheath|neuronal cell body|nuclear outer membrane|platelet dense tubular network membrane	inositol 1,3,4,5 tetrakisphosphate binding|inositol 1,4,5 trisphosphate binding|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity|inositol hexakisphosphate binding|intracellular ligand-gated calcium channel activity|protein binding			ovary(6)|lung(5)|central_nervous_system(5)|breast(2)|kidney(1)	19						TCTCCTGCCTCAGGTCTGCAG	0.647		NaN											0	0	0	1	0	14	37									
ANKS1A	23294	broad.mit.edu	37	6	34985672	34985672	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:34985672G>A	uc003ojx.3	+	11	1988	c.1846G>A	c.(1846-1848)GAA>AAA	p.E616K	ANKS1A_uc011dss.1_Intron|ANKS1A_uc011dst.1_Missense_Mutation_p.E156K|ANKS1A_uc010jvp.1_Intron	NM_015245	NP_056060	Q92625	ANS1A_HUMAN	ankyrin repeat and sterile alpha motif domain	616						cytoplasm	protein binding			ovary(3)|upper_aerodigestive_tract(1)	4						ACCCAAAGCTGAACTCAAACT	0.582		NaN											0	0	0	1	0	44	124									
CD2AP	23607	broad.mit.edu	37	6	47544302	47544302	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:47544302G>C	uc003oyw.2	+	7	1228	c.772G>C	c.(772-774)GAG>CAG	p.E258Q		NM_012120	NP_036252	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein	258					cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			TCAGAGTGTGGAGATAACAAA	0.303		NaN											0	0	0	1	0	21	76									
CD2AP	23607	broad.mit.edu	37	6	47544789	47544789	+	Nonsense_Mutation	SNP	G	G	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:47544789G>T	uc003oyw.2	+	8	1309	c.853G>T	c.(853-855)GAA>TAA	p.E285*		NM_012120	NP_036252	Q9Y5K6	CD2AP_HUMAN	CD2-associated protein	285	SH3 3.				cell division|mitosis|protein complex assembly|signal transduction|substrate-dependent cell migration, cell extension	cytoplasm|filamentous actin|nucleolus|plasma membrane|ruffle	SH3 domain binding|structural constituent of cytoskeleton			ovary(1)|skin(1)	2			Lung(136;0.105)|LUSC - Lung squamous cell carcinoma(51;0.138)			AGGTACTAATGAAGATGAACT	0.269		NaN											1	0	3.83957e-06	1	3.91515e-06	11	113									
PKHD1	5314	broad.mit.edu	37	6	51497406	51497406	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:51497406C>T	uc003pah.1	-	65	11898	c.11622G>A	c.(11620-11622)CTG>CTA	p.L3874L		NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3874	Helical; (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CCAGACAGCTCAGAGCCAGCC	0.438		NaN											0	0	0	1	0	14	43									
ZNF451	26036	broad.mit.edu	37	6	57012191	57012191	+	Silent	SNP	T	T	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:57012191T>C	uc003pdm.1	+	10	1532	c.1308T>C	c.(1306-1308)TCT>TCC	p.S436S	ZNF451_uc003pdl.2_Silent_p.S436S|ZNF451_uc003pdn.1_Silent_p.S436S|uc003pdq.1_Intron|ZNF451_uc003pdk.1_Silent_p.S436S	NM_001031623	NP_001026794	Q9Y4E5	ZN451_HUMAN	zinc finger protein 451 isoform 1	436					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)|pancreas(1)	2	Lung NSC(77;0.145)		LUSC - Lung squamous cell carcinoma(124;0.0785)|Lung(124;0.13)			TTAAAGAATCTAGCTCACTGG	0.353		NaN											0	0	0	1	0	18	56									
PHF3	23469	broad.mit.edu	37	6	64395407	64395407	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:64395407C>G	uc003pep.1	+	3	1810	c.1784C>G	c.(1783-1785)TCT>TGT	p.S595C	PHF3_uc010kaf.1_Missense_Mutation_p.S595C|PHF3_uc003pem.2_Missense_Mutation_p.S548C|PHF3_uc010kag.1_Missense_Mutation_p.S507C|PHF3_uc010kah.1_Missense_Mutation_p.S409C|PHF3_uc003pen.2_Missense_Mutation_p.S507C|PHF3_uc011dxs.1_Intron|PHF3_uc003peo.2_Missense_Mutation_p.S595C	NM_015153	NP_055968	Q92576	PHF3_HUMAN	PHD finger protein 3	595					multicellular organismal development|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(3)|lung(1)|skin(1)	5	all_cancers(3;0.0241)|all_epithelial(2;0.00306)|Lung NSC(77;0.121)		LUSC - Lung squamous cell carcinoma(74;0.0644)|Lung(124;0.148)			TTAACTCATTCTTTGAGTGAT	0.378		NaN											0	0	0	1	0	16	58									
BAI3	577	broad.mit.edu	37	6	69640534	69640534	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:69640534G>A	uc003pev.3	+	4	1289	c.841G>A	c.(841-843)GAT>AAT	p.D281N	BAI3_uc010kak.2_Missense_Mutation_p.D281N	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	281	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				GGAACAAGCTGATGCTGCTAA	0.333		NaN											0	0	0	1	0	10	31									
B3GAT2	135152	broad.mit.edu	37	6	71665851	71665851	+	Missense_Mutation	SNP	C	C	G	rs9446312		TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:71665851C>G	uc003pfv.2	-	1	938	c.282G>C	c.(280-282)CAG>CAC	p.Q94H	B3GAT2_uc011dxz.1_RNA|B3GAT2_uc003pfw.2_Missense_Mutation_p.Q94H	NM_080742	NP_542780	Q9NPZ5	B3GA2_HUMAN	beta-1,3-glucuronyltransferase 2	94	Lumenal (Potential).				carbohydrate biosynthetic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						GCTCCGCTTTCTGCACCGGGC	0.697		NaN											0	0	0	1	0	18	32									
ANKRD6	22881	broad.mit.edu	37	6	90333717	90333717	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:90333717G>C	uc003pni.3	+	12	1500	c.1159G>C	c.(1159-1161)GAG>CAG	p.E387Q	ANKRD6_uc003pne.3_Missense_Mutation_p.E387Q|ANKRD6_uc003pnf.3_Missense_Mutation_p.E352Q|ANKRD6_uc011dzy.1_Missense_Mutation_p.E387Q|ANKRD6_uc010kcd.2_Missense_Mutation_p.E328Q|LYRM2_uc010kce.1_Intron|LYRM2_uc003png.2_Intron|ANKRD6_uc003pnh.3_5'UTR|LYRM2_uc010kcf.1_Intron|ANKRD6_uc003pnj.3_5'UTR	NM_014942	NP_055757	Q9Y2G4	ANKR6_HUMAN	ankyrin repeat domain 6	387							protein binding			ovary(2)|pancreas(1)	3		all_cancers(76;1.22e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.79e-07)|all_epithelial(107;1.83e-05)|Lung NSC(302;0.239)		BRCA - Breast invasive adenocarcinoma(108;0.0209)		CCCACCCCATGAGTTCAGGGC	0.537		NaN											0	0	0	1	0	6	17									
RFX6	222546	broad.mit.edu	37	6	117243302	117243302	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:117243302G>C	uc003pxm.2	+	13	1488	c.1425G>C	c.(1423-1425)CAG>CAC	p.Q475H		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	475					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						TGGTAGAACAGAGAGTTATTA	0.378		NaN											0	0	0	1	0	19	61									
RFX6	222546	broad.mit.edu	37	6	117252568	117252568	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:117252568C>G	uc003pxm.2	+	19	2749	c.2686C>G	c.(2686-2688)CAA>GAA	p.Q896E		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	896					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						GTATCCAGCTCAAGAAACCCT	0.448		NaN											0	0	0	1	0	26	66									
THEMIS	387357	broad.mit.edu	37	6	128222209	128222209	+	Translation_Start_Site	SNP	G	G	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:128222209G>T	uc003qbi.2	-	2	188	c.-131C>A	c.(-133--129)CTCTG>CTATG		THEMIS_uc011ebt.1_Translation_Start_Site|THEMIS_uc010kfb.2_Intron	NM_001010923	NP_001010923	Q8N1K5	THMS1_HUMAN	thymocyte selection pathway associated isoform						negative T cell selection|positive T cell selection|T cell receptor signaling pathway	cytoplasm|nucleus				ovary(2)|skin(2)	4						ACTACAGCCAGAGTGGGGTGG	0.507		NaN											1	0	0.004672	1	0.00469922	3	18									
ECT2L	345930	broad.mit.edu	37	6	139206926	139206926	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:139206926G>A	uc003qif.1	+	16	2321	c.2218G>A	c.(2218-2220)GCA>ACA	p.A740T	ECT2L_uc011edq.1_Intron	NM_001077706	NP_001071174	Q008S8	ECT2L_HUMAN	epithelial cell transforming sequence 2	740	DH.				regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity				0						CTTGACCACTGCAATTGACCA	0.418		NaN											0	0	0	1	0	25	53									
NMBR	4829	broad.mit.edu	37	6	142409491	142409491	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:142409491G>C	uc003qiu.2	-	1	446	c.305C>G	c.(304-306)TCG>TGG	p.S102W		NM_002511	NP_002502	P28336	NMBR_HUMAN	neuromedin B receptor	102	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger	cytoplasm|integral to plasma membrane	bombesin receptor activity			central_nervous_system(3)|breast(1)	4	Breast(32;0.155)			OV - Ovarian serous cystadenocarcinoma(155;9.93e-06)|GBM - Glioblastoma multiforme(68;0.0013)		GAAGTAGCGCGAGGCGTCCAC	0.592		NaN											0	0	0	1	0	15	23									
NUP43	348995	broad.mit.edu	37	6	150059906	150059906	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:150059906C>G	uc003qmz.2	-	5	568	c.511G>C	c.(511-513)GAT>CAT	p.D171H	NUP43_uc003qmx.3_5'Flank|NUP43_uc011eee.1_RNA|NUP43_uc011eef.1_Intron	NM_198887	NP_942590	Q8NFH3	NUP43_HUMAN	nucleoporin 43kDa	171	WD 4.				carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			upper_aerodigestive_tract(1)	1		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;4.71e-13)|GBM - Glioblastoma multiforme(68;0.101)		GTACTACTATCTGCATTGTCT	0.333		NaN											0	0	0	1	0	25	85									
AKAP12	9590	broad.mit.edu	37	6	151671704	151671704	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:151671704C>T	uc011eep.1	+	4	2418	c.2178C>T	c.(2176-2178)GAC>GAT	p.D726D	AKAP12_uc003qoe.2_Silent_p.D726D|AKAP12_uc003qof.2_Silent_p.D628D|AKAP12_uc010kim.2_Intron|AKAP12_uc003qog.2_Silent_p.D621D	NM_005100	NP_005091	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12 isoform 1	726					G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	8		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		CGGGGACAGACGGGATCCTTG	0.587		NaN											0	0	0	1	0	40	101									
SYNE1	23345	broad.mit.edu	37	6	152477104	152477104	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:152477104C>T	uc010kiw.2	-	132	24521	c.23919G>A	c.(23917-23919)ACG>ACA	p.T7973T	SYNE1_uc010kiv.2_Silent_p.T2497T|SYNE1_uc003qos.3_Silent_p.T2497T|SYNE1_uc003qot.3_Silent_p.T7902T|SYNE1_uc003qou.3_Silent_p.T7973T|SYNE1_uc003qop.3_Silent_p.T135T|SYNE1_uc011eez.1_Silent_p.T175T|SYNE1_uc003qoq.3_Silent_p.T175T|SYNE1_uc003qor.3_Silent_p.T873T	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7973	Spectrin 28.|Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CCAGGTTTCTCGTAGCCTGCT	0.532		NaN								HNSCC(10;0.0054)			0	0	0	1	0	14	57									
THBS2	7058	broad.mit.edu	37	6	169648730	169648730	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:169648730C>T	uc003qwt.2	-	4	639	c.391G>A	c.(391-393)GAC>AAC	p.D131N		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	131	TSP N-terminal.|Heparin-binding (Potential).				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		CGGGTGCCGTCAATCCAGTAG	0.652		NaN											0	0	0	1	0	27	60									
STK31	56164	broad.mit.edu	37	7	23810669	23810669	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:23810669C>T	uc003sws.3	+	14	1826	c.1759C>T	c.(1759-1761)CAA>TAA	p.Q587*	STK31_uc003swt.3_Nonsense_Mutation_p.Q564*|STK31_uc011jze.1_Nonsense_Mutation_p.Q587*|STK31_uc010kuq.2_Nonsense_Mutation_p.Q564*	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a	587							ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						TACATATAGTCAAGTACTGCA	0.348		NaN											0	0	0	1	0	30	96									
GHRHR	2692	broad.mit.edu	37	7	31018736	31018736	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:31018736G>A	uc003tbx.2	+	13	1197	c.1149G>A	c.(1147-1149)GTG>GTA	p.V383V	GHRHR_uc003tby.2_Silent_p.V319V|GHRHR_uc003tbz.2_Missense_Mutation_p.E150K	NM_000823	NP_000814	Q02643	GHRHR_HUMAN	growth hormone releasing hormone receptor	383	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of cell proliferation|positive regulation of growth hormone secretion|positive regulation of insulin-like growth factor receptor signaling pathway|positive regulation of multicellular organism growth|response to estrogen stimulus|response to glucocorticoid stimulus	cell surface|integral to membrane|nuclear inner membrane|nuclear matrix|nuclear outer membrane|plasma membrane|stored secretory granule	growth factor binding|growth hormone-releasing hormone receptor activity|peptide hormone binding			ovary(2)|lung(1)|breast(1)|large_intestine(1)	5					Sermorelin(DB00010)	CCCTGGAGGTGAGGACTGAGA	0.592		NaN											0	0	0	1	0	10	46									
INHBA	3624	broad.mit.edu	37	7	41739721	41739721	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:41739721C>T	uc003thq.2	-	1	487	c.252G>A	c.(250-252)CTG>CTA	p.L84L	LOC285954_uc003tht.3_Intron|INHBA_uc003thr.2_Silent_p.L84L|LOC285954_uc003ths.2_Intron	NM_002192	NP_002183	P08476	INHBA_HUMAN	inhibin beta A precursor	84					cell cycle arrest|cell surface receptor linked signaling pathway|defense response|erythrocyte differentiation|eyelid development in camera-type eye|G1/S transition of mitotic cell cycle|growth|hair follicle development|hemoglobin biosynthetic process|hemopoietic progenitor cell differentiation|induction of apoptosis|male gonad development|negative regulation of B cell differentiation|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of follicle-stimulating hormone secretion|negative regulation of interferon-gamma biosynthetic process|negative regulation of macrophage differentiation|negative regulation of phosphorylation|nervous system development|odontogenesis|ovarian follicle development|palate development|positive regulation of erythrocyte differentiation|positive regulation of follicle-stimulating hormone secretion|positive regulation of ovulation|positive regulation of transcription from RNA polymerase II promoter|progesterone secretion|regulation of activin receptor signaling pathway	activin A complex|inhibin A complex	cytokine activity|follistatin binding|growth factor activity|hormone activity|identical protein binding|signal transducer activity			lung(5)|ovary(1)	6						TGATCGCGTTCAGAAGCGCCG	0.517		NaN								TSP Lung(11;0.080)			0	0	0	1	0	135	329									
CALN1	83698	broad.mit.edu	37	7	71571273	71571273	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:71571273C>T	uc003twa.3	-	3	652	c.125G>A	c.(124-126)CGA>CAA	p.R42Q	CALN1_uc003twb.3_Missense_Mutation_p.R84Q|CALN1_uc003twc.3_Missense_Mutation_p.R42Q	NM_001017440	NP_001017440	Q9BXU9	CABP8_HUMAN	calneuron 1 isoform 2	42	EF-hand 1.|Cytoplasmic (Potential).					Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			skin(1)	1		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				AAAGGCCTCTCGGATTTCTAC	0.527		NaN											0	0	0	1	0	17	29									
GTF2I	2969	broad.mit.edu	37	7	74119540	74119540	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:74119540C>G	uc003uau.2	+	7	1001	c.631C>G	c.(631-633)CCA>GCA	p.P211A	GTF2I_uc003uat.2_Missense_Mutation_p.P211A|GTF2I_uc003uav.2_Missense_Mutation_p.P211A|GTF2I_uc003uaw.2_Missense_Mutation_p.P211A|GTF2I_uc003uay.2_Missense_Mutation_p.P211A|GTF2I_uc003uax.2_Missense_Mutation_p.P211A|uc003uaz.2_Intron	NM_032999	NP_127492	P78347	GTF2I_HUMAN	general transcription factor IIi isoform 1	211					negative regulation of angiogenesis|signal transduction|transcription initiation from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity				0						AATACTATCTCCAGGTGGAAG	0.318		NaN											0	0	0	1	0	9	46									
SEMA3A	10371	broad.mit.edu	37	7	83823834	83823834	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:83823834C>T	uc003uhz.2	-	1	384	c.69G>A	c.(67-69)CAG>CAA	p.Q23Q		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	23					axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						TCTTCCCATTCTGATAGTTTG	0.418		NaN											0	0	0	1	0	37	104									
ABCB1	5243	broad.mit.edu	37	7	87196174	87196174	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:87196174G>A	uc003uiz.1	-	7	875	c.457C>T	c.(457-459)CAT>TAT	p.H153Y	ABCB1_uc011khc.1_Intron	NM_000927	NP_000918	P08183	MDR1_HUMAN	ATP-binding cassette, subfamily B, member 1	153	ABC transmembrane type-1 1.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	7	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	ATTATAGCATGAAAAAACTGT	0.418		NaN											0	0	0	1	0	9	41									
SLC26A5	375611	broad.mit.edu	37	7	103018061	103018061	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:103018061C>T	uc003vbz.2	-	18	2207	c.1971G>A	c.(1969-1971)GTG>GTA	p.V657V	SLC26A5_uc003vbt.1_Silent_p.V657V|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|SLC26A5_uc003vbw.2_RNA|SLC26A5_uc003vbx.2_Silent_p.V625V|SLC26A5_uc003vby.2_RNA|SLC26A5_uc010liy.2_RNA	NM_198999	NP_945350	P58743	S26A5_HUMAN	prestin isoform a	657	Cytoplasmic (Potential).|STAS.				regulation of cell shape|sensory perception of sound	integral to membrane	secondary active sulfate transmembrane transporter activity			ovary(1)	1						CCAGAGTTTTCACTCCAACAG	0.443		NaN											0	0	0	1	0	18	43									
ST7	7982	broad.mit.edu	37	7	116869938	116869938	+	Missense_Mutation	SNP	A	A	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:116869938A>C	uc011knn.1	+	14	1470	c.1465A>C	c.(1465-1467)ACC>CCC	p.T489P	ST7_uc003vio.2_3'UTR|ST7_uc003viq.2_3'UTR|ST7_uc011knm.1_3'UTR|ST7_uc003vir.2_3'UTR	NM_021908	NP_068708	Q9NRC1	ST7_HUMAN	suppression of tumorigenicity 7 isoform b	Error:Variant_position_missing_in_Q9NRC1_after_alignment						integral to membrane	binding			central_nervous_system(1)|skin(1)	2	all_cancers(3;3.88e-07)|all_epithelial(6;3.42e-07)|Lung NSC(10;0.00072)|all_lung(10;0.000847)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		CACTCACCTCACCCGCCGCTG	0.507		NaN											0	0	0	1	0	9	27									
FAM71F1	84691	broad.mit.edu	37	7	128356937	128356937	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:128356937C>G	uc003vno.1	+	2	373	c.320C>G	c.(319-321)TCG>TGG	p.S107W	FAM71F1_uc010llo.1_Missense_Mutation_p.S8W|FAM71F1_uc011koq.1_Silent_p.L31L|FAM71F1_uc003vnm.1_RNA|FAM71F1_uc003vnn.1_Silent_p.L28L|FAM71F1_uc010llp.1_RNA|FAM71F1_uc003vnp.1_Missense_Mutation_p.S107W	NM_032599	NP_115988	Q96KD3	F71F1_HUMAN	testes development-related NYD-SP18	107										skin(1)	1						GTGACCTCCTCGGTACCCTGC	0.587		NaN											0	0	0	1	0	7	23									
TSPAN33	340348	broad.mit.edu	37	7	128806685	128806685	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:128806685G>A	uc003vop.1	+	6	755	c.526G>A	c.(526-528)GAC>AAC	p.D176N	TSPAN33_uc003voq.1_Missense_Mutation_p.D8N	NM_178562	NP_848657	Q86UF1	TSN33_HUMAN	tetraspanin 33	176	Extracellular (Potential).					integral to membrane				ovary(1)	1						CTGCTCAGAAGACAACCCCAG	0.522		NaN											0	0	0	1	0	39	143									
MGAM	8972	broad.mit.edu	37	7	141724872	141724872	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:141724872C>T	uc003vwy.2	+	8	959	c.905C>T	c.(904-906)GCG>GTG	p.A302V		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	302	Lumenal (Potential).|Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TTGTATGGTGCGCAGACATTC	0.398		NaN											0	0	0	1	0	17	26									
MLL3	58508	broad.mit.edu	37	7	151860303	151860303	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr7:151860303G>A	uc003wla.2	-	43	10578	c.10359C>T	c.(10357-10359)TTC>TTT	p.F3453F	MLL3_uc003wkz.2_Silent_p.F2514F|MLL3_uc003wky.2_Silent_p.F962F	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	3453	Gln-rich.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CGGAACTGTAGAAGGGAATCT	0.478		NaN	N		medulloblastoma								0	0	0	1	0	49	149									
C8orf79	57604	broad.mit.edu	37	8	12879157	12879157	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr8:12879157G>C	uc010lsq.2	+	5	1461	c.969G>C	c.(967-969)TGG>TGC	p.W323C	C8orf79_uc011kxw.1_Intron|C8orf79_uc003wwj.3_Missense_Mutation_p.W236C|C8orf79_uc010lsr.2_Missense_Mutation_p.W197C	NM_020844	NP_065895	Q9P272	K1456_HUMAN	hypothetical protein LOC57604 isoform 1	323							methyltransferase activity				0						ACTTGGAGTGGCTGAGAGCAC	0.423		NaN											0	0	0	1	0	4	41									
MSR1	4481	broad.mit.edu	37	8	16026273	16026273	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr8:16026273C>T	uc003wwz.2	-	4	522	c.324G>A	c.(322-324)ATG>ATA	p.M108I	MSR1_uc010lsu.2_Missense_Mutation_p.M126I|MSR1_uc003wxa.2_Missense_Mutation_p.M108I|MSR1_uc003wxb.2_Missense_Mutation_p.M108I|MSR1_uc011kxz.1_Intron	NM_138715	NP_619729	P21757	MSRE_HUMAN	macrophage scavenger receptor 1 isoform type 1	108	Spacer (Probable).|Extracellular (Potential).				cholesterol transport|plasma lipoprotein particle clearance|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis	collagen|integral to plasma membrane|low-density lipoprotein particle	low-density lipoprotein particle binding|protein binding|scavenger receptor activity			ovary(1)	1				Colorectal(111;0.00475)|COAD - Colon adenocarcinoma(73;0.0164)		CTTGAAATCTCATTTCCTCTT	0.403		NaN											0	0	0	1	0	33	73									
TGS1	96764	broad.mit.edu	37	8	56695312	56695312	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr8:56695312G>A	uc003xsj.3	+	2	494	c.107G>A	c.(106-108)CGA>CAA	p.R36Q	TGS1_uc010lyh.2_Intron	NM_024831	NP_079107	Q96RS0	TGS1_HUMAN	trimethylguanosine synthase homolog	36					cellular lipid metabolic process|ncRNA metabolic process|regulation of transcription, DNA-dependent|RNA capping|spliceosomal snRNP assembly|transcription, DNA-dependent	Cajal body|cytosol	RNA trimethylguanosine synthase activity			ovary(1)|lung(1)|breast(1)	3		all_lung(136;0.119)|all_epithelial(80;0.125)|Lung NSC(129;0.147)	Epithelial(17;0.00027)|all cancers(17;0.00251)			CGCAGGGATCGAAAATTGTAC	0.313		NaN											0	0	0	1	0	21	55									
FAM110B	90362	broad.mit.edu	37	8	59059267	59059267	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr8:59059267G>A	uc003xtj.1	+	5	1358	c.478G>A	c.(478-480)GCG>ACG	p.A160T		NM_147189	NP_671722	Q8TC76	F110B_HUMAN	hypothetical protein LOC90362	160						microtubule organizing center|mitochondrion|nucleus				large_intestine(1)	1		all_epithelial(80;0.025)|all_lung(136;0.0274)|Lung NSC(129;0.0355)				TCACTCCTTCGCGGAGTCCCT	0.692		NaN											0	0	0	1	0	5	10									
C8orf34	116328	broad.mit.edu	37	8	69351819	69351819	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr8:69351819G>A	uc010lyz.2	+	2	204	c.155G>A	c.(154-156)CGT>CAT	p.R52H	C8orf34_uc010lyx.1_Missense_Mutation_p.R52H|C8orf34_uc010lyy.1_Missense_Mutation_p.R52H|C8orf34_uc003xyb.2_Missense_Mutation_p.R27H	NM_052958	NP_443190	Q49A92	CH034_HUMAN	hypothetical protein LOC116328	52					signal transduction		cAMP-dependent protein kinase regulator activity			large_intestine(1)	1			Epithelial(68;0.0117)|OV - Ovarian serous cystadenocarcinoma(28;0.0227)|all cancers(69;0.0502)			CAAGGGAACCGTGGACAACTT	0.403		NaN											0	0	0	1	0	17	38									
ZNF706	51123	broad.mit.edu	37	8	102213962	102213962	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr8:102213962C>G	uc003yka.2	-	3	423	c.8G>C	c.(7-9)CGT>CCT	p.R3P	ZNF706_uc003ykb.2_Missense_Mutation_p.R3P	NM_001042510	NP_001035975	Q9Y5V0	ZN706_HUMAN	HSPC038 protein	3						intracellular	zinc ion binding	p.R3P(2)		ovary(2)	2	all_cancers(14;3.3e-07)|all_epithelial(15;3.47e-09)|Lung NSC(17;3.44e-05)|all_lung(17;0.000117)		Epithelial(11;8.57e-11)|all cancers(13;1.43e-08)|OV - Ovarian serous cystadenocarcinoma(57;1.43e-05)			CTGCTGTCCACGAGCCATATC	0.398		NaN											0	0	0	1	0	7	37									
FLJ43860	389690	broad.mit.edu	37	8	142490071	142490071	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr8:142490071G>T	uc003ywi.2	-	8	995	c.914C>A	c.(913-915)ACG>AAG	p.T305K	FLJ43860_uc011ljs.1_RNA|FLJ43860_uc010meu.1_RNA	NM_207414	NP_997297	Q6ZUA9	Q6ZUA9_HUMAN	hypothetical protein LOC389690	305							binding				0	all_cancers(97;7.79e-15)|all_epithelial(106;4.52e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			TCTCCTGACCGTGGCACCGTT	0.597		NaN											1	0	1.15088e-07	1	1.1852e-07	10	35									
CYHR1	50626	broad.mit.edu	37	8	145689921	145689921	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr8:145689921G>A	uc003zcv.2	-	2	302	c.168C>T	c.(166-168)AGC>AGT	p.S56S	CYHR1_uc003zcw.2_Silent_p.S56S|CYHR1_uc003zcx.2_Silent_p.S56S|CYHR1_uc003zcy.2_Silent_p.S56S|KIFC2_uc003zcz.2_5'Flank	NM_138496	NP_612505	Q6ZMK1	CYHR1_HUMAN	cysteine/histidine-rich 1 isoform 1	56						perinuclear region of cytoplasm	zinc ion binding				0	all_cancers(97;4.61e-11)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.08e-41)|Epithelial(56;8.67e-41)|all cancers(56;1.1e-35)|BRCA - Breast invasive adenocarcinoma(115;0.035)|Colorectal(110;0.055)			CTTCGTGTGTGCTCAGCCCTG	0.637		NaN											0	0	0	1	0	20	65									
DMRT3	58524	broad.mit.edu	37	9	990293	990293	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:990293C>T	uc003zgw.1	+	2	745	c.707C>T	c.(706-708)TCG>TTG	p.S236L		NM_021240	NP_067063	Q9NQL9	DMRT3_HUMAN	doublesex and mab-3 related transcription factor	236					cell differentiation|multicellular organismal development|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			ovary(2)|central_nervous_system(1)	3		all_lung(10;1.39e-08)|Lung NSC(10;1.42e-08)		Lung(218;0.0196)		GAGGGCCCCTCGGGGACTGTT	0.572		NaN											0	0	0	1	0	18	46									
KDM4C	23081	broad.mit.edu	37	9	7174705	7174705	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:7174705G>A	uc003zkh.2	+	22	3727	c.3147G>A	c.(3145-3147)CAG>CAA	p.Q1049Q	KDM4C_uc011lmk.1_Silent_p.Q794Q|KDM4C_uc011lml.1_Silent_p.Q736Q	NM_015061	NP_055876	Q9H3R0	KDM4C_HUMAN	jumonji domain containing 2C isoform 1	1049					positive regulation of cell proliferation|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	nuclear chromatin	androgen receptor binding|enzyme binding|histone demethylase activity (H3-K9 specific)|nucleic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1						GCTCTTTCCAGAAGAAGTGCC	0.498		NaN											0	0	0	1	0	43	114									
PTPRD	5789	broad.mit.edu	37	9	8485769	8485769	+	Silent	SNP	C	C	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:8485769C>A	uc003zkk.2	-	27	3759	c.3048G>T	c.(3046-3048)GTG>GTT	p.V1016V	PTPRD_uc003zkp.2_Intron|PTPRD_uc003zkq.2_Intron|PTPRD_uc003zkr.2_Intron|PTPRD_uc003zks.2_Intron|PTPRD_uc003zkl.2_Silent_p.V1007V|PTPRD_uc003zkm.2_Silent_p.V1003V|PTPRD_uc003zkn.2_Intron|PTPRD_uc003zko.2_Intron	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1016	Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TACCTTGATCCACAGGCAGTG	0.448		NaN								TSP Lung(15;0.13)			1	0	5.9392e-07	1	6.10418e-07	4	9									
PTPRD	5789	broad.mit.edu	37	9	8633395	8633395	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:8633395C>G	uc003zkk.2	-	13	985	c.274G>C	c.(274-276)GAT>CAT	p.D92H	PTPRD_uc003zkp.2_Missense_Mutation_p.D92H|PTPRD_uc003zkq.2_Missense_Mutation_p.D92H|PTPRD_uc003zkr.2_Missense_Mutation_p.D92H|PTPRD_uc003zks.2_Missense_Mutation_p.D92H|PTPRD_uc003zkl.2_Missense_Mutation_p.D92H|PTPRD_uc003zkm.2_Missense_Mutation_p.D92H|PTPRD_uc003zkn.2_Missense_Mutation_p.D92H|PTPRD_uc003zko.2_Missense_Mutation_p.D92H|PTPRD_uc003zkt.1_Missense_Mutation_p.D92H	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	92	Ig-like C2-type 1.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		ATGGCCTCATCCCTCGGAGTC	0.443		NaN								TSP Lung(15;0.13)			0	0	0	1	0	28	72									
PSIP1	11168	broad.mit.edu	37	9	15474012	15474012	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:15474012C>T	uc003zlv.3	-	9	1183	c.853G>A	c.(853-855)GAA>AAA	p.E285K	PSIP1_uc003zlw.3_Missense_Mutation_p.E285K|PSIP1_uc003zlz.3_Missense_Mutation_p.E285K|PSIP1_uc003zma.3_Missense_Mutation_p.E276K|PSIP1_uc003zly.2_Missense_Mutation_p.E285K	NM_033222	NP_150091	O75475	PSIP1_HUMAN	PC4 and SFRS1 interacting protein 1 isoform 2	285					initiation of viral infection|interspecies interaction between organisms|nuclear mRNA 5'-splice site recognition|provirus integration|regulation of transcription, DNA-dependent|response to heat|response to oxidative stress|transcription, DNA-dependent	cytosol|nuclear heterochromatin|nuclear periphery|nucleoplasm|nucleoplasm|transcriptionally active chromatin	activating transcription factor binding|chromatin binding|DNA secondary structure binding|RNA polymerase II transcription coactivator activity			breast(1)	1				GBM - Glioblastoma multiforme(50;2.38e-06)		TATACCTTTTCACCTTCTTGA	0.249		NaN											0	0	0	1	0	8	46									
C9orf72	203228	broad.mit.edu	37	9	27561630	27561630	+	Silent	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:27561630G>C	uc003zqq.2	-	5	715	c.618C>G	c.(616-618)CTC>CTG	p.L206L	C9orf72_uc003zqr.1_Silent_p.L206L	NM_018325	NP_060795	Q96LT7	CI072_HUMAN	hypothetical protein LOC203228 isoform a	206										ovary(3)|central_nervous_system(1)	4		all_neural(11;7.57e-10)		LUSC - Lung squamous cell carcinoma(38;0.0001)|Lung(218;0.00016)		CATCATCATTGAGTACTGTAT	0.313		NaN											0	0	0	1	0	11	41									
BAG1	573	broad.mit.edu	37	9	33256861	33256861	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:33256861C>T	uc003zsj.2	-	5	912	c.823G>A	c.(823-825)GAT>AAT	p.D275N	SUGT1P1_uc010mjq.1_Intron|BAG1_uc003zsi.2_Missense_Mutation_p.D137N|BAG1_uc003zsk.2_Missense_Mutation_p.D101N	NM_004323	NP_004314	Q99933	BAG1_HUMAN	BCL2-associated athanogene isoform 1L	275	Interaction with PPP1R15A.|BAG.				anti-apoptosis|apoptosis|cell surface receptor linked signaling pathway|chaperone cofactor-dependent protein refolding	cytoplasm|intermediate filament cytoskeleton|nucleus	protein binding|receptor signaling protein activity			ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.00506)			ACTCTCCTATCAAGTTTGCAG	0.428		NaN											0	0	0	1	0	22	66									
SLC28A3	64078	broad.mit.edu	37	9	86917179	86917179	+	Nonsense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:86917179G>A	uc010mpz.2	-	5	585	c.460C>T	c.(460-462)CGA>TGA	p.R154*	SLC28A3_uc011lsy.1_Nonsense_Mutation_p.R85*|SLC28A3_uc004anu.1_Nonsense_Mutation_p.R154*|SLC28A3_uc010mqb.2_Nonsense_Mutation_p.R85*	NM_022127	NP_071410	Q9HAS3	S28A3_HUMAN	concentrative Na+-nucleoside cotransporter	154	Cytoplasmic (Potential).				nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|skin(1)	4						TCATCAATTCGATGTTCGTAT	0.453		NaN											0	0	0	1	0	21	45									
ROR2	4920	broad.mit.edu	37	9	94493358	94493358	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:94493358C>T	uc004arj.1	-	7	1216	c.1017G>A	c.(1015-1017)CCG>CCA	p.P339P	ROR2_uc004ari.1_Silent_p.P199P|ROR2_uc004ark.2_Silent_p.P339P	NM_004560	NP_004551	Q01974	ROR2_HUMAN	receptor tyrosine kinase-like orphan receptor 2	339	Extracellular (Potential).|Kringle.				negative regulation of cell proliferation|positive regulation of cell migration|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity|Wnt-protein binding			lung(8)|central_nervous_system(5)|ovary(3)|large_intestine(2)|stomach(1)|breast(1)	20						GCAGGGCCCACGGCTGGCACT	0.612		NaN											0	0	0	1	0	33	51									
FGD3	89846	broad.mit.edu	37	9	95784614	95784614	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:95784614G>A	uc004asw.2	+	14	2128	c.1500G>A	c.(1498-1500)ACG>ACA	p.T500T	FGD3_uc004asx.2_Silent_p.T500T|FGD3_uc004asz.2_Silent_p.T500T|FGD3_uc011luc.1_Silent_p.T103T	NM_001083536	NP_001077005	Q5JSP0	FGD3_HUMAN	FYVE, RhoGEF and PH domain containing 3	500					actin cytoskeleton organization|apoptosis|filopodium assembly|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Cdc42 GTPase activity|regulation of cell shape|small GTPase mediated signal transduction	cytoskeleton|cytosol|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			ovary(1)|breast(1)	2						TCTAGATCACGAGCACCAGCC	0.637		NaN											0	0	0	1	0	16	40									
ZNF462	58499	broad.mit.edu	37	9	109690005	109690005	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:109690005C>T	uc004bcz.2	+	3	4101	c.3812C>T	c.(3811-3813)TCA>TTA	p.S1271L	ZNF462_uc010mto.2_Missense_Mutation_p.S1119L|ZNF462_uc004bda.2_Missense_Mutation_p.S1119L	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	1271	C2H2-type 11.				transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						AGGCAGTGCTCATATACCTCC	0.522		NaN											0	0	0	1	0	70	158									
ZNF462	58499	broad.mit.edu	37	9	109690177	109690177	+	Silent	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:109690177C>G	uc004bcz.2	+	3	4273	c.3984C>G	c.(3982-3984)CTC>CTG	p.L1328L	ZNF462_uc010mto.2_Silent_p.L1176L|ZNF462_uc004bda.2_Silent_p.L1176L	NM_021224	NP_067047	Q96JM2	ZN462_HUMAN	zinc finger protein 462	1328					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(5)	5						ACGGTTTGCTCCTGCATTACC	0.527		NaN											0	0	0	1	0	33	105									
KLF4	9314	broad.mit.edu	37	9	110250458	110250458	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:110250458C>T	uc004bdh.2	-	3	811	c.190G>A	c.(190-192)GAC>AAC	p.D64N	KLF4_uc004bdf.1_Missense_Mutation_p.D23N|KLF4_uc004bdg.2_Missense_Mutation_p.D73N	NM_004235	NP_004226	O43474	KLF4_HUMAN	Kruppel-like factor 4 (gut)	73					fat cell differentiation|mesodermal cell fate determination|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|stem cell maintenance|transcription from RNA polymerase II promoter	nucleus	RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor recruiting transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(2)|lung(1)	3						CTCTCCAGGTCTGTGGCCACG	0.697		NaN											0	0	0	1	0	5	20									
KIAA0368	23392	broad.mit.edu	37	9	114134882	114134882	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:114134882G>C	uc004bfe.1	-	43	4889	c.4889C>G	c.(4888-4890)TCT>TGT	p.S1630C		NM_001080398	NP_001073867			KIAA0368 protein												0						CAAAGCACAAGAGGTCTTGTA	0.363		NaN											0	0	0	1	0	5	24									
DBC1	1620	broad.mit.edu	37	9	121929416	121929416	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:121929416C>T	uc004bkc.2	-	8	2688	c.2232G>A	c.(2230-2232)CTG>CTA	p.L744L		NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	744					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						CCGTGTTGTACAGGTCCAAGG	0.527		NaN											0	0	0	1	0	28	127									
DBC1	1620	broad.mit.edu	37	9	121930184	121930184	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:121930184C>T	uc004bkc.2	-	8	1920	c.1464G>A	c.(1462-1464)CTG>CTA	p.L488L		NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	488					cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						GCAGGTACTTCAGCTCCAGGT	0.577		NaN											0	0	0	1	0	9	34									
SH2D3C	10044	broad.mit.edu	37	9	130506924	130506924	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:130506924G>A	uc004bsc.2	-	7	1861	c.1719C>T	c.(1717-1719)GGC>GGT	p.G573G	SH2D3C_uc010mxo.2_Silent_p.G413G|SH2D3C_uc004bry.2_Silent_p.G415G|SH2D3C_uc004brz.3_Silent_p.G219G|SH2D3C_uc011mak.1_Silent_p.G219G|SH2D3C_uc004bsa.2_Silent_p.G416G|SH2D3C_uc004bsb.2_Silent_p.G505G	NM_170600	NP_733745	Q8N5H7	SH2D3_HUMAN	SH2 domain containing 3C isoform a	573					JNK cascade|small GTPase mediated signal transduction	cytoplasm|membrane	guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			ovary(1)	1						TGCGCAGAAGGCCCACCTCCA	0.612		NaN											0	0	0	1	0	31	93									
SETX	23064	broad.mit.edu	37	9	135153600	135153600	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:135153600G>A	uc004cbk.2	-	21	6882	c.6699C>T	c.(6697-6699)TTC>TTT	p.F2233F	SETX_uc004cbj.2_Silent_p.F1852F|SETX_uc010mzt.2_Silent_p.F1852F	NM_015046	NP_055861	Q7Z333	SETX_HUMAN	senataxin	2233					cell death|double-strand break repair|RNA processing	cytoplasm|nucleolus|nucleoplasm	ATP binding|DNA helicase activity			ovary(2)|skin(1)	3		Myeloproliferative disorder(178;0.204)		OV - Ovarian serous cystadenocarcinoma(145;6.82e-06)|Epithelial(140;0.000171)		GCAGTCTGCAGAAGCGAGCCA	0.458		NaN											0	0	0	1	0	30	88									
FCN1	2219	broad.mit.edu	37	9	137809709	137809709	+	Silent	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:137809709C>G	uc004cfi.2	-	1	101	c.9G>C	c.(7-9)CTG>CTC	p.L3L		NM_002003	NP_001994	O00602	FCN1_HUMAN	ficolin 1 precursor	3					opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding			large_intestine(1)|ovary(1)	2		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)		TGGCTCCACTCAGCTCCATGC	0.587		NaN											0	0	0	1	0	21	51									
SEC16A	9919	broad.mit.edu	37	9	139358973	139358973	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:139358973G>A	uc004chx.2	-	9	4654	c.4345C>T	c.(4345-4347)CAT>TAT	p.H1449Y	SEC16A_uc004chv.3_Missense_Mutation_p.H839Y|SEC16A_uc004chw.2_Missense_Mutation_p.H1449Y|SEC16A_uc010nbn.2_Missense_Mutation_p.H1449Y	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	1271					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		GCACAGACATGAGGCACTGAA	0.458		NaN											0	0	0	1	0	20	66									
C9orf86	55684	broad.mit.edu	37	9	139726762	139726762	+	Silent	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:139726762G>A	uc004cji.1	+	7	913	c.645G>A	c.(643-645)AAG>AAA	p.K215K	C9orf86_uc004cjm.2_Silent_p.K215K|C9orf86_uc004cjh.2_Silent_p.K215K|C9orf86_uc004cjj.1_Silent_p.K216K|C9orf86_uc004cjk.1_RNA|C9orf86_uc010nbr.1_Silent_p.K215K|C9orf86_uc004cjl.1_RNA|C9orf86_uc010nbs.1_Silent_p.K100K|C9orf86_uc004cjn.1_5'Flank	NM_024718	NP_078994	Q3YEC7	PARF_HUMAN	Rab-like GTP-binding protein 1 isoform 1	215	Small GTPase-like.				small GTPase mediated signal transduction	cytoplasm|nucleus	GTP binding|protein binding				0	all_cancers(76;0.0763)|all_epithelial(76;0.198)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;1.61e-05)|Epithelial(140;0.000183)		CTTCCATGAAGAACAGCTTCG	0.493		NaN											0	0	0	1	0	25	58									
MXRA5	25878	broad.mit.edu	37	X	3239561	3239561	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:3239561C>T	uc004crg.3	-	5	4322	c.4165G>A	c.(4165-4167)GGG>AGG	p.G1389R		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1389						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TGTAGCCTCCCAGGCTGGGCC	0.507		NaN											0	0	0	1	0	15	8									
MXRA5	25878	broad.mit.edu	37	X	3239741	3239741	+	Missense_Mutation	SNP	C	C	T	rs146955381	byFrequency	TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:3239741C>T	uc004crg.3	-	5	4142	c.3985G>A	c.(3985-3987)GAT>AAT	p.D1329N		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1329						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GTGGCAACATCATCCTTAATT	0.373		NaN											0	0	0	1	0	41	35									
MXRA5	25878	broad.mit.edu	37	X	3239744	3239744	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:3239744C>T	uc004crg.3	-	5	4139	c.3982G>A	c.(3982-3984)GAT>AAT	p.D1328N		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1328						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				GCAACATCATCCTTAATTTCT	0.373		NaN											0	0	0	1	0	39	34									
PIR	8544	broad.mit.edu	37	X	15474083	15474083	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:15474083G>C	uc004cwu.2	-	5	606	c.368C>G	c.(367-369)TCA>TGA	p.S123*	PIR_uc004cwv.2_Nonsense_Mutation_p.S123*	NM_003662	NP_003653	O00625	PIR_HUMAN	pirin	123					transcription from RNA polymerase II promoter	cytoplasm|nucleus	metal ion binding|protein binding|quercetin 2,3-dioxygenase activity|transcription cofactor activity			ovary(1)	1	Hepatocellular(33;0.183)					CATCTTCTCTGAGCTCCTCAA	0.527		NaN											0	0	0	1	0	24	146									
NHS	4810	broad.mit.edu	37	X	17750460	17750460	+	Missense_Mutation	SNP	G	G	C	rs140651691	byFrequency	TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:17750460G>C	uc004cxx.2	+	8	5107	c.4769G>C	c.(4768-4770)AGC>ACC	p.S1590T	NHS_uc011mix.1_Missense_Mutation_p.S1611T|NHS_uc004cxy.2_Missense_Mutation_p.S1434T|NHS_uc004cxz.2_Missense_Mutation_p.S1413T|NHS_uc004cya.2_Missense_Mutation_p.S1313T	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	1590						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)					CCTGCAGCCAGCAGCAGCCGC	0.592		NaN											0	0	0	1	0	4	47									
CACNA1F	778	broad.mit.edu	37	X	49065842	49065842	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:49065842C>T	uc004dnb.2	-	42	4928	c.4866G>A	c.(4864-4866)CGG>CGA	p.R1622R	CACNA1F_uc010nip.2_Silent_p.R1611R	NM_005183	NP_005174	O60840	CAC1F_HUMAN	calcium channel, voltage-dependent, L type,	1622	Cytoplasmic (Potential).				axon guidance|detection of light stimulus involved in visual perception	voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			breast(3)|ovary(1)|kidney(1)|skin(1)	6					Verapamil(DB00661)	CCTGCAGGCTCCGCAGACCAG	0.468		NaN											0	0	0	1	0	6	10									
RRAGB	10325	broad.mit.edu	37	X	55784744	55784744	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:55784744G>A	uc004dup.2	+	11	1744	c.1093G>A	c.(1093-1095)GAT>AAT	p.D365N	RRAGB_uc004duq.2_Missense_Mutation_p.D337N	NM_016656	NP_057740	Q5VZM2	RRAGB_HUMAN	Ras-related GTP binding B long isoform	365					cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade|signal transduction	Golgi apparatus|lysosome|nucleus	GTP binding|protein binding				0						GGAAAGAGTGGATGGACCAAA	0.403		NaN											0	0	0	1	0	9	5									
ZNF75D	7626	broad.mit.edu	37	X	134425016	134425016	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:134425016C>G	uc004eyp.2	-	6	3397	c.742G>C	c.(742-744)GAG>CAG	p.E248Q	ZNF75D_uc004eym.2_Intron|ZNF75D_uc004eyn.2_Missense_Mutation_p.E27Q|ZNF75D_uc004eyo.2_Missense_Mutation_p.E153Q	NM_007131	NP_009062	P51815	ZN75D_HUMAN	zinc finger protein 75	248	KRAB.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						AATTGCCACTCTTCCTCAGAA	0.393		NaN											0	0	0	1	0	8	85									
SLC9A6	10479	broad.mit.edu	37	X	135126738	135126738	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:135126738G>A	uc004ezj.2	+	16	1941	c.1865G>A	c.(1864-1866)GGA>GAA	p.G622E	SLC9A6_uc004ezk.2_Missense_Mutation_p.G654E	NM_006359	NP_006350	Q92581	SL9A6_HUMAN	solute carrier family 9 (sodium/hydrogen	622					regulation of pH	early endosome membrane|endoplasmic reticulum membrane|integral to membrane|microsome|plasma membrane|recycling endosome membrane	sodium:hydrogen antiporter activity			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					AGATTTATGGGAAACAGTTCT	0.468		NaN											0	0	0	1	0	23	17									
GPR112	139378	broad.mit.edu	37	X	135428058	135428058	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:135428058G>C	uc004ezu.1	+	6	2484	c.2193G>C	c.(2191-2193)TTG>TTC	p.L731F	GPR112_uc010nsb.1_Missense_Mutation_p.L526F|GPR112_uc010nsc.1_Missense_Mutation_p.L498F	NM_153834	NP_722576	Q8IZF6	GP112_HUMAN	G-protein coupled receptor 112	731	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(5)|large_intestine(2)|skin(2)|lung(1)|breast(1)|pancreas(1)	12	Acute lymphoblastic leukemia(192;0.000127)					TATCCAAATTGACATCACCAT	0.398		NaN											0	0	0	1	0	29	17									
GPR101	83550	broad.mit.edu	37	X	136113174	136113174	+	Silent	SNP	C	C	T			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:136113174C>T	uc011mwh.1	-	1	660	c.660G>A	c.(658-660)CGG>CGA	p.R220R		NM_054021	NP_473362	Q96P66	GP101_HUMAN	G protein-coupled receptor 101	220	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					CATGCTGCCTCCGGGCTGCAC	0.537		NaN											0	0	0	1	0	33	22									
MAGEC1	9947	broad.mit.edu	37	X	140996131	140996131	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:140996131G>C	uc004fbt.2	+	4	3227	c.2941G>C	c.(2941-2943)GAC>CAC	p.D981H	MAGEC1_uc010nsl.1_Missense_Mutation_p.D48H	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	981	MAGE.						protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AAACACATTAGACCTCACCTC	0.468		NaN								HNSCC(15;0.026)			0	0	0	1	0	52	44									
GPR50	9248	broad.mit.edu	37	X	150349067	150349067	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrX:150349067G>A	uc010ntg.1	+	2	1147	c.1012G>A	c.(1012-1014)GCC>ACC	p.A338T	uc004fes.1_5'Flank|GPR50_uc011myc.1_3'UTR	NM_004224	NP_004215	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	338	Cytoplasmic (Potential).|Pro-rich.				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					CCTGGCCCGCGCCCGTGCCCA	0.567		NaN											0	0	0	1	0	8	95									
RPS4Y2	140032	broad.mit.edu	37	Y	22918664	22918664	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chrY:22918664G>A	uc011nbb.1	+	2	100	c.4G>A	c.(4-6)GCC>ACC	p.A2T		NM_001039567	NP_001034656	Q8TD47	RS4Y2_HUMAN	ribosomal protein S4, Y-linked 2	2					translation	ribosome	rRNA binding|structural constituent of ribosome				0						TCTTTTTCAGGCCCGGGGCCC	0.433		NaN											0	0	0	1	0	6	10									
PRKD3	23683	broad.mit.edu	37	2	37513484	37513484	+	Frame_Shift_Del	DEL	C	C	-			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr2:37513484delC	uc002rqd.2	-	5	1301	c.746delG	c.(745-747)AGAfs	p.R249fs	PRKD3_uc002rqf.1_Frame_Shift_Del_p.R249fs	NM_005813	NP_005804	O94806	KPCD3_HUMAN	protein kinase D3	249					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction	cytoplasm|membrane|nucleus	ATP binding|metal ion binding|protein binding|protein kinase C activity			lung(2)|ovary(1)|central_nervous_system(1)	4		all_hematologic(82;0.21)				AGAAGGAATTCTCTTACTTGG	0.418		NaN											NaN	NaN	NaN	NaN	NaN	15	52	---	---							
EP300	2033	broad.mit.edu	37	22	41564578	41564580	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08			GAA	-	GAA	GAA		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr22:41564578_41564580delGAA	uc003azl.3	+	24	4395_4397	c.4000_4002delGAA	c.(4000-4002)GAAdel	p.E1334del		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	1334					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						CAAAACCGTGGAAGTAAAACCAG	0.429		NaN	T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				NaN	NaN	NaN	NaN	NaN	15	49	---	---							
CDKN1A	1026	broad.mit.edu	37	6	36652198	36652199	+	Frame_Shift_Ins	INS	-	-	G			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08			-	G	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr6:36652198_36652199insG	uc003omm.3	+	2	442_443	c.320_321insG	c.(319-321)GAGfs	p.E107fs	CDKN1A_uc011dtq.1_Frame_Shift_Ins_p.E141fs|CDKN1A_uc003oml.2_Frame_Shift_Ins_p.E107fs|CDKN1A_uc003omn.2_Frame_Shift_Ins_p.E107fs	NM_000389	NP_000380	P38936	CDN1A_HUMAN	cyclin-dependent kinase inhibitor 1A	107					cell cycle arrest|cellular response to extracellular stimulus|cellular response to ionizing radiation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|negative regulation of cell growth|negative regulation of cell proliferation|positive regulation of fibroblast proliferation|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|S phase of mitotic cell cycle|stress-induced premature senescence	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleoplasm|PCNA-p21 complex	cyclin-dependent protein kinase activating kinase activity|cyclin-dependent protein kinase inhibitor activity|metal ion binding			ovary(1)|breast(1)	2						GGGACAGCAGAGGAAGACCATG	0.653		NaN							Multiple_Endocrine_Neoplasia_type_1				NaN	NaN	NaN	NaN	NaN	8	19	---	---							
LY96	23643	broad.mit.edu	37	8	74903693	74903693	+	Frame_Shift_Del	DEL	T	T	-			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr8:74903693delT	uc003yad.2	+	1	107	c.16delT	c.(16-18)TTTfs	p.F6fs		NM_015364	NP_056179	Q9Y6Y9	LY96_HUMAN	MD-2 protein precursor	6					cellular defense response|detection of lipopolysaccharide|I-kappaB kinase/NF-kappaB cascade|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	extracellular space|lipopolysaccharide receptor complex|plasma membrane	coreceptor activity|lipopolysaccharide receptor activity|protein binding				0	Breast(64;0.0311)		Epithelial(68;0.0208)|BRCA - Breast invasive adenocarcinoma(89;0.0499)|all cancers(69;0.0619)			ACCATTTCTGTTTTTTTCCAC	0.368		NaN											NaN	NaN	NaN	NaN	NaN	23	75	---	---							
RAD23B	5887	broad.mit.edu	37	9	110062443	110062451	+	In_Frame_Del	DEL	ATTGAATCT	ATTGAATCT	-			TCGA-FD-A3SO-01A-11D-A22Z-08	TCGA-FD-A3SO-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	ab0a322d-4945-4ed1-88fa-d36a7e13a9db	c21f9933-734e-4834-a89d-5c4b683cecae	g.chr9:110062443_110062451delATTGAATCT	uc004bde.2	+	2	455_463	c.88_96delATTGAATCT	c.(88-96)ATTGAATCTdel	p.IES30del	RAD23B_uc011lwa.1_In_Frame_Del_p.IES30del|RAD23B_uc011lwb.1_In_Frame_Del_p.IES9del	NM_002874	NP_002865	P54727	RD23B_HUMAN	UV excision repair protein RAD23 homolog B	30_32	Ubiquitin-like.				nucleotide-excision repair, DNA damage recognition|nucleotide-excision repair, DNA damage removal|proteasomal ubiquitin-dependent protein catabolic process|regulation of proteasomal ubiquitin-dependent protein catabolic process	cytoplasm|nucleoplasm|proteasome complex|XPC complex	damaged DNA binding|polyubiquitin binding|single-stranded DNA binding			ovary(1)	1						GAAAGAGAAGATTGAATCTGAAAAGGGGA	0.287		NaN						Direct_reversal_of_damage|NER					NaN	NaN	NaN	NaN	NaN	16	55	---	---							
