Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
EPHA2	1969	broad.mit.edu	37	1	16464437	16464437	+	Missense_Mutation	SNP	T	T	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr1:16464437T>C	uc001aya.1	-	5	1360	c.1223A>G	c.(1222-1224)TAC>TGC	p.Y408C	EPHA2_uc010oca.1_Missense_Mutation_p.Y408C	NM_004431	NP_004422	P29317	EPHA2_HUMAN	ephrin receptor EphA2 precursor	408	Extracellular (Potential).|Fibronectin type-III 1.				activation of Rac GTPase activity|angiogenesis|apoptosis|cell chemotaxis|negative regulation of protein kinase B signaling cascade|positive regulation of establishment of protein localization in plasma membrane|protein kinase B signaling cascade|regulation of blood vessel endothelial cell migration|regulation of cell adhesion mediated by integrin|regulation of lamellipodium assembly|response to growth factor stimulus	focal adhesion|integral to plasma membrane|lamellipodium membrane|ruffle membrane	ATP binding|ephrin receptor activity|protein binding			lung(3)|central_nervous_system(3)|stomach(2)|ovary(2)	10		Colorectal(325;3.46e-05)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0221)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0181)|Colorectal(212;3.63e-07)|COAD - Colon adenocarcinoma(227;2.25e-05)|BRCA - Breast invasive adenocarcinoma(304;9.58e-05)|Kidney(64;0.000175)|KIRC - Kidney renal clear cell carcinoma(64;0.00261)|STAD - Stomach adenocarcinoma(313;0.00669)|READ - Rectum adenocarcinoma(331;0.0649)	Dasatinib(DB01254)	GGTGAAGGTGTAGTTCATGTG	0.627		NaN											0	0	0	0.00361	0	46	36									
ARHGEF10L	55160	broad.mit.edu	37	1	17939589	17939589	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr1:17939589G>A	uc001ban.2	+	8	805	c.646G>A	c.(646-648)GCC>ACC	p.A216T	ARHGEF10L_uc009vpe.1_Intron|ARHGEF10L_uc001bao.2_Intron|ARHGEF10L_uc001bap.2_Intron|ARHGEF10L_uc010ocr.1_Intron|ARHGEF10L_uc001baq.2_5'Flank	NM_018125	NP_060595	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF)	216					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|ovary(1)|pancreas(1)	3		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		GGAGAGATACGCCAGGACTAA	0.547		NaN											0	0	0	0.002836	0	28	126									
EIF4G3	8672	broad.mit.edu	37	1	21186926	21186926	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr1:21186926C>G	uc001bec.2	-	19	3284	c.3028G>C	c.(3028-3030)GAG>CAG	p.E1010Q	EIF4G3_uc010odi.1_Missense_Mutation_p.E614Q|EIF4G3_uc010odj.1_Missense_Mutation_p.E1009Q|EIF4G3_uc009vpz.2_Missense_Mutation_p.E730Q|EIF4G3_uc001bed.2_Missense_Mutation_p.E1010Q|EIF4G3_uc001bef.2_Missense_Mutation_p.E1046Q|EIF4G3_uc001bee.2_Missense_Mutation_p.E1016Q	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	1010	eIF3/EIF4A-binding (By similarity).|Potential.				interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		TTCCTTTGCTCTTCTTGTTCT	0.428		NaN											0	0	0	0.00361	0	58	63									
BAI2	576	broad.mit.edu	37	1	32222088	32222088	+	Missense_Mutation	SNP	G	G	A	rs145025368		TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr1:32222088G>A	uc001btn.2	-	4	704	c.350C>T	c.(349-351)GCG>GTG	p.A117V	BAI2_uc010ogp.1_Missense_Mutation_p.A105V|BAI2_uc010ogq.1_Missense_Mutation_p.A117V|BAI2_uc001bto.2_Missense_Mutation_p.A117V|BAI2_uc001btq.1_Missense_Mutation_p.A105V|BAI2_uc010ogr.1_Missense_Mutation_p.A105V	NM_001703	NP_001694	O60241	BAI2_HUMAN	brain-specific angiogenesis inhibitor 2	117	Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(5)|breast(4)|ovary(2)|central_nervous_system(1)|skin(1)	13		Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0606)|all_neural(195;0.0837)|Breast(348;0.174)		STAD - Stomach adenocarcinoma(196;0.0557)		CTGGGCCACCGCCTCCTCGGG	0.687		NaN											0	0	0	0.004672	0	3	14									
CYP4B1	1580	broad.mit.edu	37	1	47279201	47279201	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr1:47279201C>G	uc001cqm.3	+	5	627	c.543C>G	c.(541-543)TTC>TTG	p.F181L	CYP4B1_uc009vyl.1_Missense_Mutation_p.F18L|CYP4B1_uc001cqn.3_Missense_Mutation_p.F181L|CYP4B1_uc009vym.2_Missense_Mutation_p.F166L|CYP4B1_uc010omk.1_Missense_Mutation_p.F18L|CYP4B1_uc010oml.1_Missense_Mutation_p.F18L	NM_000779	NP_000770	P13584	CP4B1_HUMAN	cytochrome P450, family 4, subfamily B,	181					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(166;0.155)					TTGACATCTTCTGCGATGTGG	0.572		NaN											0	0	0	0.008871	0	17	80									
SLC44A5	204962	broad.mit.edu	37	1	75862289	75862289	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr1:75862289G>A	uc001dgu.2	-	3	175	c.31C>T	c.(31-33)CCC>TCC	p.P11S	SLC44A5_uc001dgt.2_Missense_Mutation_p.P11S|SLC44A5_uc001dgs.2_5'UTR|SLC44A5_uc001dgr.2_5'UTR|SLC44A5_uc010oqz.1_Missense_Mutation_p.P50S|SLC44A5_uc010ora.1_Intron|SLC44A5_uc010orb.1_5'UTR	NM_152697	NP_689910	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5 isoform A	11	Cytoplasmic (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4						TCCTCAGAGGGAGTATCTGCT	0.363		NaN											0	0	0	0.00361	0	63	51									
ARHGAP29	9411	broad.mit.edu	37	1	94697113	94697113	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr1:94697113G>C	uc001dqj.3	-	2	424	c.55C>G	c.(55-57)CAA>GAA	p.Q19E	ARHGAP29_uc009wdq.1_RNA|ARHGAP29_uc001dql.2_Missense_Mutation_p.Q19E	NM_004815	NP_004806	Q52LW3	RHG29_HUMAN	PTPL1-associated RhoGAP 1	19					Rho protein signal transduction	cytosol	metal ion binding|Rho GTPase activator activity			breast(4)|skin(3)|lung(2)|upper_aerodigestive_tract(1)|ovary(1)	11		all_lung(203;0.000732)|Lung NSC(277;0.00328)		all cancers(265;0.0187)|Epithelial(280;0.159)		GTAGAGAGTTGACCTGATGCC	0.388		NaN											0	0	0	0.005443	0	20	154									
DBT	1629	broad.mit.edu	37	1	100706396	100706396	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr1:100706396C>A	uc001dta.2	-	2	129	c.96G>T	c.(94-96)TTG>TTT	p.L32F	DBT_uc010oug.1_5'UTR	NM_001918	NP_001909	P11182	ODB2_HUMAN	dihydrolipoamide branched chain transacylase	32					branched chain family amino acid catabolic process|fatty-acyl-CoA biosynthetic process	microtubule cytoskeleton|mitochondrial alpha-ketoglutarate dehydrogenase complex|mitochondrial nucleoid	acyltransferase activity|cofactor binding|dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity|protein binding			pancreas(1)	1		all_epithelial(167;5.4e-06)|all_lung(203;0.00125)|Lung NSC(277;0.00131)		Epithelial(280;0.0739)|all cancers(265;0.123)|COAD - Colon adenocarcinoma(174;0.154)|Lung(183;0.199)		AATTTGGCTTCAAAACATGAA	0.323		NaN											1	0	5.82388e-19	0.00361	6.16791e-19	45	56									
ATP1A1	476	broad.mit.edu	37	1	116941293	116941293	+	Silent	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr1:116941293G>A	uc001ege.2	+	16	2514	c.2175G>A	c.(2173-2175)TTG>TTA	p.L725L	ATP1A1_uc010owv.1_Silent_p.L694L|ATP1A1_uc010oww.1_Silent_p.L725L|ATP1A1_uc010owx.1_Silent_p.L694L|C1orf203_uc009whb.2_Intron|ATP1A1_uc001egh.2_5'Flank	NM_000701	NP_000692	P05023	AT1A1_HUMAN	Na+/K+ -ATPase alpha 1 subunit isoform a	725	Cytoplasmic (Potential).				ATP biosynthetic process	melanosome|sodium:potassium-exchanging ATPase complex	ATP binding|metal ion binding|protein binding|sodium:potassium-exchanging ATPase activity			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;1.28e-06)|all_epithelial(167;3.48e-07)|all_lung(203;2.64e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0164)|LUSC - Lung squamous cell carcinoma(189;0.0548)|Colorectal(144;0.0825)|COAD - Colon adenocarcinoma(174;0.127)|all cancers(265;0.24)	Acetyldigitoxin(DB00511)|Almitrine(DB01430)|Aluminium(DB01370)|Bepridil(DB01244)|Bretylium(DB01158)|Captopril(DB01197)|Deslanoside(DB01078)|Diazoxide(DB01119)|Digitoxin(DB01396)|Digoxin(DB00390)|Esomeprazole(DB00736)|Ethacrynic acid(DB00903)|Furosemide(DB00695)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Ouabain(DB01092)|Pantoprazole(DB00213)|Trichlormethiazide(DB01021)	CTCCAGCTTTGAAGAAAGCAG	0.483		NaN											0	0	0	0.004878	0	31	160									
PDE4DIP	9659	broad.mit.edu	37	1	144946680	144946680	+	Missense_Mutation	SNP	C	C	T	rs144942272		TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr1:144946680C>T	uc001elw.3	-	5	872	c.581G>A	c.(580-582)CGG>CAG	p.R194Q	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Missense_Mutation_p.R260Q|PDE4DIP_uc001emc.1_Missense_Mutation_p.R194Q|PDE4DIP_uc001emd.1_Missense_Mutation_p.R194Q	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	194	Potential.				cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		TTGTTTCTCCCGAGATAGCTG	0.458		NaN	T	PDGFRB	MPD								0	0	0	0.004482	0	8	67									
NBPF10	100132406	broad.mit.edu	37	1	145367739	145367739	+	Silent	SNP	A	A	G	rs146714035	by1000genomes	TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr1:145367739A>G	uc001end.3	+	85	10595	c.10560A>G	c.(10558-10560)AAA>AAG	p.K3520K	NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3445											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		ggaaggggaaaaaaagaaggg	0.244		NaN											0	0	0	0.009096	0	3	50									
NBPF10	100132406	broad.mit.edu	37	1	145367767	145367767	+	Missense_Mutation	SNP	G	G	A	rs77484671		TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr1:145367767G>A	uc001end.3	+	85	10623	c.10588G>A	c.(10588-10590)GAA>AAA	p.E3530K	NBPF9_uc010oye.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_Intron|NBPF10_uc010oyk.1_Intron|NBPF10_uc010oyl.1_Intron	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	3455											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		atcaaagaaggaaagaagaag	0.254		NaN											0	0	0	0.006214	0	7	45									
ECM1	1893	broad.mit.edu	37	1	150484939	150484939	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr1:150484939C>T	uc001eus.2	+	8	1394	c.1195C>T	c.(1195-1197)CGG>TGG	p.R399W	ECM1_uc001eut.2_Missense_Mutation_p.R274W|ECM1_uc001euu.2_Missense_Mutation_p.R428W|ECM1_uc001euv.2_Missense_Mutation_p.R426W|ECM1_uc009wlu.2_Missense_Mutation_p.R159W	NM_004425	NP_004416	Q16610	ECM1_HUMAN	extracellular matrix protein 1 isoform 1	399	2 X approximate repeats.|2.				angiogenesis|biomineral tissue development|negative regulation of bone mineralization|negative regulation of peptidase activity|ossification|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade	proteinaceous extracellular matrix	laminin binding|protease binding|protein C-terminus binding|signal transducer activity			ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.29e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			CTTTGCCCGTCGGGCTCCTTA	0.567		NaN											0	0	0	0.00278	0	21	100									
FLG2	388698	broad.mit.edu	37	1	152325463	152325463	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr1:152325463C>T	uc001ezw.3	-	3	4872	c.4799G>A	c.(4798-4800)GGC>GAC	p.G1600D	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1600							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCGGCTTGGCCGTAAGTGTG	0.507		NaN											0	0	0	0.00361	0	145	131									
F5	2153	broad.mit.edu	37	1	169510442	169510442	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr1:169510442G>C	uc001ggg.1	-	13	4031	c.3886C>G	c.(3886-3888)CCA>GCA	p.P1296A		NM_000130	NP_000121	P12259	FA5_HUMAN	coagulation factor V precursor	1296	2-13.|35 X 9 AA approximate tandem repeats of [TNP]-L-S-P-D-L-S-Q-T.|B.				cell adhesion|platelet activation|platelet degranulation	plasma membrane|platelet alpha granule lumen	copper ion binding|oxidoreductase activity			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	all_hematologic(923;0.208)				Drotrecogin alfa(DB00055)	CTGAGTTCTGGAGAGAGGTTT	0.522		NaN											0	0	0	0.00361	0	151	173									
RYR2	6262	broad.mit.edu	37	1	237944916	237944916	+	Missense_Mutation	SNP	A	A	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr1:237944916A>T	uc001hyl.1	+	89	12052	c.11932A>T	c.(11932-11934)ATG>TTG	p.M3978L	RYR2_uc010pya.1_Missense_Mutation_p.M393L	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3978	Helical; Name=M2; (Potential).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GCAGAAGGATATGGTGGTCAT	0.318		NaN											0	0	0	0.000602	0	3	5									
ITGA8	8516	broad.mit.edu	37	10	15760899	15760899	+	Splice_Site	SNP	C	C	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr10:15760899C>G	uc001ioc.1	-	2	210	c.210_splice	c.e2-1	p.T70_splice	ITGA8_uc010qcb.1_Splice_Site_p.T70_splice	NM_003638	NP_003629	P53708	ITA8_HUMAN	integrin, alpha 8 precursor						cell differentiation|cell-cell adhesion|cell-matrix adhesion|integrin-mediated signaling pathway|nervous system development	integrin complex	receptor activity			ovary(3)|lung(3)	6						GACACTCGCTCTGCAAAAGAG	0.607		NaN											0	0	0	0.00874	0	39	55									
FAM13C	220965	broad.mit.edu	37	10	61012730	61012730	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr10:61012730C>T	uc001jkn.2	-	13	1495	c.1361G>A	c.(1360-1362)CGT>CAT	p.R454H	FAM13C_uc001jko.2_Missense_Mutation_p.R356H|FAM13C_uc010qid.1_Missense_Mutation_p.R370H|FAM13C_uc010qie.1_Missense_Mutation_p.R371H|FAM13C_uc010qif.1_Missense_Mutation_p.R476H	NM_198215	NP_937858	Q8NE31	FA13C_HUMAN	hypothetical protein LOC220965 isoform 1	454										ovary(2)	2						TCCCTGTGGACGGTCTTCATC	0.483		NaN											0	0	0	0.003271	0	29	53									
PDE6C	5146	broad.mit.edu	37	10	95396758	95396758	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr10:95396758C>G	uc001kiu.3	+	11	1558	c.1420C>G	c.(1420-1422)CAA>GAA	p.Q474E		NM_006204	NP_006195	P51160	PDE6C_HUMAN	phosphodiesterase 6C	474					visual perception	plasma membrane	3',5'-cyclic-GMP phosphodiesterase activity|cGMP binding|metal ion binding			ovary(2)|kidney(1)|skin(1)	4		Colorectal(252;0.123)				TTAGAAATTTCAAGAGAAGTT	0.289		NaN											0	0	0	0.008871	0	17	10									
NRAP	4892	broad.mit.edu	37	10	115401142	115401142	+	Silent	SNP	A	A	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr10:115401142A>G	uc001laj.2	-	13	1469	c.1305T>C	c.(1303-1305)GTT>GTC	p.V435V	NRAP_uc001lak.2_Silent_p.V400V|NRAP_uc001lal.3_Silent_p.V435V	NM_198060	NP_932326	Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein isoform S	435	Nebulin 10.					fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			ovary(6)|central_nervous_system(3)|upper_aerodigestive_tract(1)	10		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		CCAGGCTGCCAACTTTCATAG	0.458		NaN											0	0	0	0.00361	0	51	26									
SEC23IP	11196	broad.mit.edu	37	10	121652431	121652431	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr10:121652431C>G	uc001leu.1	+	1	209	c.137C>G	c.(136-138)TCT>TGT	p.S46C	SEC23IP_uc010qtc.1_Missense_Mutation_p.L13V	NM_007190	NP_009121	Q9Y6Y8	S23IP_HUMAN	Sec23-interacting protein p125	46	Interaction with SEC23A.				Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			ovary(3)	3		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		GCCTCCGCTTCTCCGGCCTCC	0.622		NaN											0	0	0	0.00361	0	50	9									
TACC2	10579	broad.mit.edu	37	10	123845062	123845062	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr10:123845062G>C	uc001lfv.2	+	4	3407	c.3047G>C	c.(3046-3048)GGA>GCA	p.G1016A	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Missense_Mutation_p.G1016A|TACC2_uc010qtv.1_Missense_Mutation_p.G1016A	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	1016						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				AGGCATCCAGGAGCTTCTGAA	0.557		NaN											0	0	0	0.007413	0	16	10									
MUC5B	727897	broad.mit.edu	37	11	1268537	1268537	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:1268537C>A	uc009ycr.1	+	50	12137	c.12011C>A	c.(12010-12012)TCG>TAG	p.S4004*	MUC5B_uc001ltb.2_Nonsense_Mutation_p.S3479*	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	3476	7 X Cys-rich subdomain repeats.|Thr-rich.			Missing (in Ref. 6; AAB61398).	cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		TCGGCCACCTCGGGCATCTTG	0.672		NaN											1	0	2.87052e-16	0.005524	3.02731e-16	24	130									
TRPM5	29850	broad.mit.edu	37	11	2443523	2443523	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:2443523G>A	uc001lwm.3	-	2	155	c.146C>T	c.(145-147)CCG>CTG	p.P49L	TRPM5_uc010qxl.1_Missense_Mutation_p.P49L|TRPM5_uc009ydn.2_Missense_Mutation_p.P49L	NM_014555	NP_055370	Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel,	49	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		GAGCACAGACGGGGCCACTCC	0.662		NaN											0	0	0	0.004289	0	33	60									
NAP1L4	4676	broad.mit.edu	37	11	2975840	2975840	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:2975840C>A	uc001lxc.2	-	12	1093	c.952G>T	c.(952-954)GAA>TAA	p.E318*	NAP1L4_uc001lxb.2_5'Flank|NAP1L4_uc009ydt.2_RNA|NAP1L4_uc010qxm.1_Nonsense_Mutation_p.E318*|NAP1L4_uc010qxn.1_Nonsense_Mutation_p.E318*	NM_005969	NP_005960	Q99733	NP1L4_HUMAN	nucleosome assembly protein 1-like 4	318					nucleosome assembly	chromatin assembly complex|cytoplasm	unfolded protein binding			ovary(1)	1		all_epithelial(84;0.000236)|Medulloblastoma(188;0.00106)|Breast(177;0.00328)|Ovarian(85;0.00556)|all_neural(188;0.00681)		BRCA - Breast invasive adenocarcinoma(625;0.00301)|LUSC - Lung squamous cell carcinoma(625;0.211)		TGTCCAATTTCAAAATCAGAG	0.448		NaN											1	0	7.11191e-15	0.002836	7.46899e-15	32	37									
ZNF195	7748	broad.mit.edu	37	11	3380678	3380678	+	Silent	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:3380678C>T	uc001lxt.2	-	6	1738	c.1560G>A	c.(1558-1560)AAG>AAA	p.K520K	uc001lxr.2_5'Flank|ZNF195_uc001lxv.2_Silent_p.K497K|ZNF195_uc001lxs.2_Silent_p.K448K|ZNF195_uc010qxr.1_Silent_p.K501K|ZNF195_uc009ydz.2_Silent_p.K475K|ZNF195_uc001lxu.2_Silent_p.K452K	NM_001130520	NP_001123992	O14628	ZN195_HUMAN	zinc finger protein 195 isoform 1	520					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Medulloblastoma(188;0.00106)|Breast(177;0.00328)|all_neural(188;0.00681)|Ovarian(85;0.00965)		BRCA - Breast invasive adenocarcinoma(625;0.0361)|LUSC - Lung squamous cell carcinoma(625;0.2)		ATTTGTAGGGCTTCTCTCCAG	0.403		NaN											0	0	0	0.009096	0	4	171									
HPS5	11234	broad.mit.edu	37	11	18322409	18322409	+	Silent	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:18322409C>T	uc001mod.1	-	9	1229	c.951G>A	c.(949-951)CAG>CAA	p.Q317Q	HPS5_uc001moe.1_Silent_p.Q203Q|HPS5_uc001mof.1_Silent_p.Q203Q	NM_181507	NP_852608	Q9UPZ3	HPS5_HUMAN	Hermansky-Pudlak syndrome 5 isoform a	317						cytosol				ovary(1)|pancreas(1)|skin(1)	3						CTTGAACATTCTGAGGAATGA	0.323		NaN							Hermansky-Pudlak_syndrome				0	0	0	0.003954	0	20	19									
ARHGAP1	392	broad.mit.edu	37	11	46700690	46700690	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:46700690G>A	uc001ndd.2	-	13	1286	c.1217C>T	c.(1216-1218)GCG>GTG	p.A406V		NM_004308	NP_004299	Q07960	RHG01_HUMAN	Rho GTPase activating protein 1	406	Rho-GAP.				Rho protein signal transduction	cytosol|intracellular membrane-bounded organelle	SH3 domain binding|SH3/SH2 adaptor activity			skin(1)	1		Lung NSC(402;1.76e-12)|all_lung(304;1.3e-11)		GBM - Glioblastoma multiforme(35;5.17e-06)|BRCA - Breast invasive adenocarcinoma(625;0.00112)|Lung(87;0.153)		GGTGATGGCCGCATCCTTGGC	0.552		NaN											0	0	0	0.009096	0	4	107									
OR4X2	119764	broad.mit.edu	37	11	48267009	48267009	+	Silent	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:48267009C>T	uc001ngs.1	+	1	354	c.354C>T	c.(352-354)ATC>ATT	p.I118I		NM_001004727	NP_001004727	Q8NGF9	OR4X2_HUMAN	olfactory receptor, family 4, subfamily X,	118	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						ATGTGGCCATCTGCAAGCCCC	0.512		NaN											0	0	0	0.011902	0	44	47									
VWCE	220001	broad.mit.edu	37	11	61039180	61039180	+	Silent	SNP	C	C	T	rs141642839		TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:61039180C>T	uc001nra.2	-	14	2031	c.1752G>A	c.(1750-1752)TCG>TCA	p.S584S	VWCE_uc001nrb.2_RNA	NM_152718	NP_689931	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	584	VWFC 4.					extracellular region	calcium ion binding			ovary(1)	1						GGTCACCAGGCGACCAGATCT	0.557		NaN											0	0	0	0.001984	0	6	40									
GANAB	23193	broad.mit.edu	37	11	62397103	62397103	+	Silent	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:62397103G>C	uc001nub.2	-	15	1824	c.1791C>G	c.(1789-1791)CCC>CCG	p.P597P	GANAB_uc001ntz.2_5'Flank|GANAB_uc001nua.2_Silent_p.P619P|GANAB_uc001nuc.2_Silent_p.P500P|GANAB_uc010rma.1_Silent_p.P505P|GANAB_uc010rmb.1_Silent_p.P483P	NM_198334	NP_938148	Q14697	GANAB_HUMAN	neutral alpha-glucosidase AB isoform 2	597					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5						CCAGGACAAAGGGGCGTTCCA	0.597		NaN											0	0	0	0.00499	0	14	35									
DKFZp761E198	91056	broad.mit.edu	37	11	65547046	65547046	+	Silent	SNP	T	T	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:65547046T>C	uc001ofo.3	-	1	777	c.747A>G	c.(745-747)GCA>GCG	p.A249A		NM_138368	NP_612377	Q2VPB7	YK046_HUMAN	hypothetical protein LOC91056	249	Leu-rich.						protein binding				0				READ - Rectum adenocarcinoma(159;0.167)		GCTTGAAGAGTGCCGGTGGCT	0.642		NaN											0	0	0	0.001168	0	5	6									
CCDC87	55231	broad.mit.edu	37	11	66360121	66360121	+	Silent	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:66360121C>T	uc001oiq.3	-	1	434	c.366G>A	c.(364-366)CTG>CTA	p.L122L	CCS_uc001oir.2_5'Flank	NM_018219	NP_060689	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	122										ovary(1)|skin(1)	2						GCTCGCTGCTCAGCAGCACGT	0.627		NaN									OREG0021111	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00361	0	48	57									
LRP5	4041	broad.mit.edu	37	11	68171050	68171050	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:68171050G>C	uc001ont.2	+	8	1759	c.1684G>C	c.(1684-1686)GAC>CAC	p.D562H	LRP5_uc009ysg.2_5'UTR	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	562	YWTD 8.|Beta-propeller 2.|LDL-receptor class B 10.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						CTACTGGACTGACTGGCAGCG	0.597		NaN											0	0	0	0.005524	0	35	61									
MYO7A	4647	broad.mit.edu	37	11	76873903	76873903	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:76873903C>G	uc001oyb.2	+	14	1831	c.1559C>G	c.(1558-1560)ACA>AGA	p.T520R	MYO7A_uc010rsl.1_Missense_Mutation_p.T520R|MYO7A_uc010rsm.1_Missense_Mutation_p.T509R|MYO7A_uc001oyc.2_Missense_Mutation_p.T520R	NM_000260	NP_000251	Q13402	MYO7A_HUMAN	myosin VIIA isoform 1	520	Myosin head-like.				actin filament-based movement|equilibrioception|lysosome organization|sensory perception of sound|visual perception	cytosol|lysosomal membrane|myosin complex|photoreceptor inner segment|photoreceptor outer segment|synapse	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|breast(1)	4						CCCCAGGGCACAGACACCACC	0.587		NaN											0	0	0	0.00361	0	70	73									
FAT3	120114	broad.mit.edu	37	11	92616246	92616246	+	Silent	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:92616246G>A	uc001pdj.3	+	23	12641	c.12624G>A	c.(12622-12624)CCG>CCA	p.P4208P	FAT3_uc001pdi.3_Silent_p.P648P	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	4208	Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				ATGGCATCCCGTTCCGGAACC	0.657		NaN								TCGA Ovarian(4;0.039)			0	0	0	0.004007	0	14	96									
HYOU1	10525	broad.mit.edu	37	11	118919580	118919580	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:118919580C>T	uc001puu.2	-	18	2204	c.2011G>A	c.(2011-2013)GAG>AAG	p.E671K	HYOU1_uc001put.2_Missense_Mutation_p.E636K|HYOU1_uc010ryu.1_Missense_Mutation_p.E629K|HYOU1_uc010ryv.1_Missense_Mutation_p.E560K|HYOU1_uc001pux.3_Missense_Mutation_p.E671K|HYOU1_uc010ryw.1_RNA	NM_006389	NP_006380	Q9Y4L1	HYOU1_HUMAN	hypoxia up-regulated 1 precursor	671						endoplasmic reticulum lumen	ATP binding|protein binding				0	all_hematologic(175;0.0839)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)|all_hematologic(192;0.207)		BRCA - Breast invasive adenocarcinoma(274;7.78e-05)		GGCCCTGCCTCTGCCTTCTCA	0.612		NaN											0	0	0	0.00361	0	46	40									
CCDC153	283152	broad.mit.edu	37	11	119061144	119061144	+	Silent	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:119061144G>C	uc010rze.1	-	7	586	c.498C>G	c.(496-498)CTC>CTG	p.L166L		NM_001145018	NP_001138490	Q494R4	CC153_HUMAN	coiled-coil domain containing 153	166											0						GCTTGGCCAAGAGCCTGTCCA	0.562		NaN											0	0	0	0.00361	0	74	56									
TECTA	7007	broad.mit.edu	37	11	120989224	120989224	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:120989224G>C	uc010rzo.1	+	6	1000	c.1000G>C	c.(1000-1002)GAC>CAC	p.D334H		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	334	VWFD 1.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		CCACACTTTTGACGGCTTCCT	0.557		NaN											0	0	0	0.003163	0	15	93									
IGSF9B	22997	broad.mit.edu	37	11	133789947	133789947	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr11:133789947G>A	uc001qgx.3	-	18	3904	c.3673C>T	c.(3673-3675)CGC>TGC	p.R1225C		NM_014987	NP_055802	Q9UPX0	TUTLB_HUMAN	immunoglobulin superfamily, member 9B	1225	Pro-rich.|Cytoplasmic (Potential).					integral to membrane|plasma membrane					0	all_hematologic(175;0.127)	all_cancers(12;1.58e-21)|all_epithelial(12;5.17e-16)|all_lung(97;1.6e-05)|Lung NSC(97;3.86e-05)|Breast(109;0.000126)|Medulloblastoma(222;0.0245)|all_neural(223;0.0505)|Esophageal squamous(93;0.0559)		Epithelial(10;7.19e-10)|BRCA - Breast invasive adenocarcinoma(10;9.69e-09)|all cancers(11;1.23e-08)|OV - Ovarian serous cystadenocarcinoma(99;0.00328)|Lung(977;0.221)		AGGCCCGGGCGAGGCCGGGCA	0.677		NaN											0	0	0	0.009535	0	27	18									
CHD4	1108	broad.mit.edu	37	12	6707456	6707456	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr12:6707456C>T	uc001qpo.2	-	11	1782	c.1618G>A	c.(1618-1620)GAG>AAG	p.E540K	CHD4_uc001qpn.2_Missense_Mutation_p.E533K|CHD4_uc001qpp.2_Missense_Mutation_p.E537K	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	540	Chromo 1.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						AACTGCCGCTCTGGCCGCCCC	0.572		NaN											0	0	0	0.00361	0	123	115									
KLRC4	8302	broad.mit.edu	37	12	10560257	10560257	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr12:10560257G>C	uc001qye.2	-	4	654	c.472C>G	c.(472-474)CTA>GTA	p.L158V	KLRK1_uc001qyc.2_5'UTR|KLRK1_uc009zhk.2_5'UTR|KLRK1_uc001qyd.2_5'UTR	NM_013431	NP_038459	O43908	NKG2F_HUMAN	killer cell lectin-like receptor subfamily C,	158	Extracellular (Potential).				cellular defense response	integral to membrane	binding|receptor activity				0						ATTATCTATAGAAAGCAGATC	0.274		NaN											0	0	0	0.00361	0	61	180									
ANO6	196527	broad.mit.edu	37	12	45823019	45823019	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr12:45823019G>C	uc001roo.2	+	20	2993	c.2658G>C	c.(2656-2658)ATG>ATC	p.M886I	ANO6_uc010sld.1_Intron|ANO6_uc010sle.1_Intron|ANO6_uc010slf.1_Missense_Mutation_p.M907I|ANO6_uc010slg.1_Missense_Mutation_p.M868I	NM_001025356	NP_001020527	Q4KMQ2	ANO6_HUMAN	anoctamin 6 isoform a	886	Cytoplasmic (Potential).				activation of blood coagulation via clotting cascade|phosphatidylserine exposure on blood platelet	chloride channel complex|plasma membrane	chloride channel activity			ovary(1)|kidney(1)	2						TCAAAGATATGACGAAAAATA	0.388		NaN											0	0	0	0.004007	0	13	36									
ANKRD52	283373	broad.mit.edu	37	12	56641847	56641847	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr12:56641847G>C	uc001skm.3	-	18	2028	c.1938C>G	c.(1936-1938)ATC>ATG	p.I646M		NM_173595	NP_775866	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	646	ANK 18.						protein binding			ovary(2)	2						TGCGCTCCTTGATGAGGGCAG	0.637		NaN											0	0	0	0.008291	0	10	15									
GNS	2799	broad.mit.edu	37	12	65110565	65110565	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr12:65110565G>A	uc001ssg.3	-	14	1785	c.1615C>T	c.(1615-1617)CGC>TGC	p.R539C	GNS_uc001ssf.2_Missense_Mutation_p.R483C|GNS_uc010ssq.1_Missense_Mutation_p.R571C|GNS_uc010ssr.1_Missense_Mutation_p.R519C	NM_002076	NP_002067	P15586	GNS_HUMAN	glucosamine (N-acetyl)-6-sulfatase precursor	539						lysosome	metal ion binding|N-acetylglucosamine-6-sulfatase activity|protein binding			central_nervous_system(1)	1	Lung NSC(1;7.25e-14)|all_lung(1;1.25e-12)		LUAD - Lung adenocarcinoma(6;0.115)	GBM - Glioblastoma multiforme(28;0.0435)		ACACTGCCGCGATTGCTGAAC	0.473		NaN											0	0	0	0.010504	0	15	53									
TMTC2	160335	broad.mit.edu	37	12	83081401	83081401	+	Silent	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr12:83081401C>T	uc001szt.2	+	1	468	c.36C>T	c.(34-36)CTC>CTT	p.L12L	TMTC2_uc001szr.1_Silent_p.L12L|TMTC2_uc001szs.1_Silent_p.L12L|TMTC2_uc010suk.1_5'UTR	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat	12						endoplasmic reticulum|integral to membrane	binding			ovary(2)	2						CTCTGGGGCTCGCCTTGTATC	0.627		NaN									OREG0022010	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001368	0	11	25									
OAS2	4939	broad.mit.edu	37	12	113440781	113440781	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr12:113440781C>A	uc001tuj.2	+	6	1193	c.1053C>A	c.(1051-1053)TTC>TTA	p.F351L	OAS2_uc001tui.1_Missense_Mutation_p.F351L	NM_016817	NP_058197	P29728	OAS2_HUMAN	2'-5'-oligoadenylate synthetase 2 isoform 1	351	OAS domain 2.				interferon-gamma-mediated signaling pathway|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|type I interferon-mediated signaling pathway	endoplasmic reticulum|membrane|microsome|mitochondrion|nucleus	ATP binding|nucleotidyltransferase activity|RNA binding			ovary(1)	1						TGGATAAGTTCATCAAGGAGT	0.507		NaN											1	0	2.37301e-105	0.00361	2.63551e-105	169	189									
WSB2	55884	broad.mit.edu	37	12	118480669	118480669	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr12:118480669C>T	uc001twr.2	-	4	634	c.536G>A	c.(535-537)CGC>CAC	p.R179H	WSB2_uc010sza.1_5'UTR|WSB2_uc010szb.1_Intron|WSB2_uc009zws.1_Missense_Mutation_p.R179H	NM_018639	NP_061109	Q9NYS7	WSB2_HUMAN	WD SOCS-box protein 2	179	WD 2.				intracellular signal transduction					ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GTCCCAGATGCGAAGAGTCTT	0.458		NaN											0	0	0	0.009718	0	39	146									
GALNT9	50614	broad.mit.edu	37	12	132685671	132685671	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr12:132685671C>G	uc001ukc.3	-	8	1515	c.1399G>C	c.(1399-1401)GAG>CAG	p.E467Q	GALNT9_uc009zyr.2_Missense_Mutation_p.E241Q|GALNT9_uc001ukb.2_Missense_Mutation_p.E324Q|GALNT9_uc001uka.2_Missense_Mutation_p.E101Q	NM_001122636	NP_001116108	Q9HCQ5	GALT9_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide	467	Ricin B-type lectin.|Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.241)		OV - Ovarian serous cystadenocarcinoma(86;7.49e-08)|Epithelial(86;3.55e-07)|all cancers(50;2.09e-05)		GGTGCTACCTCTCCGTACGTG	0.607		NaN											0	0	0	0.004482	0	6	21									
FRY	10129	broad.mit.edu	37	13	32821530	32821530	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr13:32821530C>T	uc001utx.2	+	48	7395	c.6899C>T	c.(6898-6900)CCT>CTT	p.P2300L	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	2300					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CTTGTTTTACCTTCATACCAG	0.433		NaN											0	0	0	0.00361	0	67	88									
FREM2	341640	broad.mit.edu	37	13	39262725	39262725	+	Missense_Mutation	SNP	T	T	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr13:39262725T>A	uc001uwv.2	+	1	1553	c.1244T>A	c.(1243-1245)GTG>GAG	p.V415E		NM_207361	NP_997244	Q5SZK8	FREM2_HUMAN	FRAS1-related extracellular matrix protein 2	415	CSPG 1.|Extracellular (Potential).				cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(7)|pancreas(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	11		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		TTGGAGGTAGTGGATCTAGAA	0.532		NaN											0	0	0	0.007413	0	18	55									
OR4K14	122740	broad.mit.edu	37	14	20482654	20482654	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr14:20482654G>T	uc010tky.1	-	1	699	c.699C>A	c.(697-699)AGC>AGA	p.S233R		NM_001004712	NP_001004712	Q8NGD5	OR4KE_HUMAN	olfactory receptor, family 4, subfamily K,	233	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|large_intestine(1)	3	all_cancers(95;0.00108)		Epithelial(56;4.65e-07)|all cancers(55;2e-06)	GBM - Glioblastoma multiforme(265;0.00124)		CTTTGGATGTGCTACCGGCAG	0.502		NaN											1	0	0.00307968	0.00308	0.00310442	8	15									
SLC7A8	23428	broad.mit.edu	37	14	23596404	23596404	+	Silent	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr14:23596404C>T	uc001wiz.2	-	11	2316	c.1590G>A	c.(1588-1590)GCG>GCA	p.A530A	SLC7A8_uc001wiw.2_Silent_p.A147A|SLC7A8_uc001wix.2_Silent_p.A327A|SLC7A8_uc010tnk.1_Silent_p.A306A|SLC7A8_uc010tnl.1_Silent_p.A425A|SLC7A8_uc001wiy.2_RNA|SLC7A8_uc010akj.2_3'UTR	NM_012244	NP_036376	Q9UHI5	LAT2_HUMAN	solute carrier family 7 (cationic amino acid	530					blood coagulation|cellular amino acid metabolic process|leukocyte migration|metal ion homeostasis|response to toxin	basolateral plasma membrane|cytoplasm|integral to plasma membrane	neutral amino acid transmembrane transporter activity|organic cation transmembrane transporter activity|peptide antigen binding|protein binding|toxin transporter activity			ovary(1)	1	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.00809)	L-Alanine(DB00160)|L-Glutamine(DB00130)|L-Phenylalanine(DB00120)	GGGGCTGCCCCGCCACGTCCT	0.617		NaN											0	0	0	0.003271	0	27	74									
CLEC14A	161198	broad.mit.edu	37	14	38724762	38724762	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr14:38724762C>T	uc001wum.1	-	1	813	c.466G>A	c.(466-468)GGC>AGC	p.G156S		NM_175060	NP_778230	Q86T13	CLC14_HUMAN	C-type lectin domain family 14, member A	156	Extracellular (Potential).|C-type lectin.					integral to membrane	sugar binding			ovary(3)|skin(1)	4	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00439)		TCCTTCCAGCCTGCGGGCTCG	0.572		NaN											0	0	0	0.003755	0	30	32									
DAAM1	23002	broad.mit.edu	37	14	59820639	59820639	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr14:59820639G>C	uc001xdz.1	+	20	2468	c.2343G>C	c.(2341-2343)AAG>AAC	p.K781N	DAAM1_uc001xea.1_Missense_Mutation_p.K771N|DAAM1_uc001xec.1_5'Flank	NM_014992	NP_055807	Q9Y4D1	DAAM1_HUMAN	dishevelled-associated activator of	781	FH2.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.165)		ACTTCAAAAAGAAGTTTGCAG	0.348		NaN											0	0	0	0.00245	0	11	47									
VTI1B	10490	broad.mit.edu	37	14	68120200	68120200	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr14:68120200C>T	uc001xjt.2	-	5	952	c.556G>A	c.(556-558)GAA>AAA	p.E186K	VTI1B_uc010aqp.2_Missense_Mutation_p.E125K|VTI1B_uc001xju.2_Missense_Mutation_p.E145K	NM_006370	NP_006361	Q9UEU0	VTI1B_HUMAN	vesicle transport through interaction with	186	Potential.|Cytoplasmic (Potential).				cell proliferation|cellular membrane fusion|intracellular protein transport|vesicle docking involved in exocytosis	endomembrane system|integral to membrane					0				all cancers(60;0.000344)|OV - Ovarian serous cystadenocarcinoma(108;0.00212)|BRCA - Breast invasive adenocarcinoma(234;0.00941)		CTCAAGTTTTCACTTGTGTTT	0.333		NaN											0	0	0	0.00245	0	12	46									
SIPA1L1	26037	broad.mit.edu	37	14	72196849	72196849	+	Silent	SNP	G	G	A	rs141905323		TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr14:72196849G>A	uc001xms.2	+	18	5103	c.4755G>A	c.(4753-4755)TCG>TCA	p.S1585S	SIPA1L1_uc001xmt.2_Silent_p.S1564S|SIPA1L1_uc001xmu.2_Silent_p.S1564S|SIPA1L1_uc001xmv.2_Silent_p.S1585S|SIPA1L1_uc010ttm.1_Silent_p.S1039S|SIPA1L1_uc001xmw.2_Silent_p.S350S	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	1585					actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		GAACACTGTCGGACGAGAGCA	0.557		NaN											0	0	0	0.001984	0	6	88									
BTBD7	55727	broad.mit.edu	37	14	93714878	93714878	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr14:93714878G>C	uc001ybo.2	-	9	2391	c.2065C>G	c.(2065-2067)CAG>GAG	p.Q689E	BTBD7_uc010aur.2_Missense_Mutation_p.Q214E|BTBD7_uc010two.1_Missense_Mutation_p.Q509E|BTBD7_uc001ybp.2_Missense_Mutation_p.Q338E	NM_001002860	NP_001002860	Q9P203	BTBD7_HUMAN	BTB (POZ) domain containing 7 isoform 1	689										pancreas(1)	1		all_cancers(154;0.08)		Epithelial(152;0.196)|COAD - Colon adenocarcinoma(157;0.212)|all cancers(159;0.223)		ACTCGAATCTGAATTTCATAG	0.517		NaN											0	0	0	0.00623	0	29	32									
DICER1	23405	broad.mit.edu	37	14	95562743	95562743	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr14:95562743G>C	uc001ydw.2	-	24	4696	c.4514C>G	c.(4513-4515)TCT>TGT	p.S1505C	DICER1_uc010avh.1_Missense_Mutation_p.S403C|DICER1_uc001ydv.2_Missense_Mutation_p.S1495C|DICER1_uc001ydx.2_Missense_Mutation_p.S1505C|DICER1_uc001ydy.1_Missense_Mutation_p.S357C	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	1505					negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		TGCATCCCAAGAGCTGTAGTC	0.408		NaN	Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				0	0	0	0.00333	0	24	55									
APBA2	321	broad.mit.edu	37	15	29346371	29346371	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr15:29346371A>G	uc001zck.2	+	3	491	c.284A>G	c.(283-285)GAG>GGG	p.E95G	APBA2_uc010azj.2_Missense_Mutation_p.E95G|APBA2_uc010uat.1_Missense_Mutation_p.E95G|APBA2_uc001zcl.2_Missense_Mutation_p.E95G|APBA2_uc010uas.1_Missense_Mutation_p.E95G	NM_005503	NP_005494	Q99767	APBA2_HUMAN	amyloid beta A4 precursor protein-binding,	95	Poly-Glu.				nervous system development|protein transport		protein binding				0		all_lung(180;1.73e-12)|Breast(32;2.89e-05)|Colorectal(260;0.234)		all cancers(64;7.44e-11)|Epithelial(43;5.74e-10)|GBM - Glioblastoma multiforme(186;0.026)|BRCA - Breast invasive adenocarcinoma(123;0.0286)|Lung(196;0.24)		GAGGAGGAGGAGGGCATCACC	0.607		NaN											0	0	0	0.009096	0	3	170									
TMEM87A	25963	broad.mit.edu	37	15	42512293	42512293	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr15:42512293C>T	uc010udd.1	-	16	1603	c.1444G>A	c.(1444-1446)GAA>AAA	p.E482K		NM_015497	NP_056312	Q8NBN3	TM87A_HUMAN	transmembrane protein 87A isoform 1	482	Poly-Glu.					integral to membrane				ovary(1)	1		all_cancers(109;4.28e-16)|all_epithelial(112;1.04e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;1.03e-06)		TCCTTTTGTTCATCCTCCTCC	0.318		NaN											0	0	0	0.004289	0	27	91									
DENND4A	10260	broad.mit.edu	37	15	66015201	66015201	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr15:66015201G>A	uc002aph.2	-	12	1951	c.1573C>T	c.(1573-1575)CAG>TAG	p.Q525*	DENND4A_uc002api.2_Nonsense_Mutation_p.Q525*|DENND4A_uc002apj.3_Nonsense_Mutation_p.Q525*|DENND4A_uc010ujj.1_Nonsense_Mutation_p.Q525*	NM_005848	NP_005839	Q7Z401	MYCPP_HUMAN	DENN/MADD domain containing 4A isoform 2	525					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	4						GCCAATTGCTGATGCAAATTA	0.308		NaN											0	0	0	0.00308	0	7	27									
PAQR5	54852	broad.mit.edu	37	15	69677202	69677202	+	Silent	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr15:69677202C>T	uc002arz.2	+	5	744	c.366C>T	c.(364-366)GCC>GCT	p.A122A	PAQR5_uc002asa.2_Silent_p.A122A	NM_017705	NP_060175	Q9NXK6	MPRG_HUMAN	progestin and adipoQ receptor family member V	122	Helical; Name=3; (Potential).				cell differentiation|multicellular organismal development|oogenesis	integral to membrane	receptor activity|steroid binding			ovary(2)	2						ACTATGGTGCCGTCAACCTCT	0.562		NaN											0	0	0	0.006122	0	16	19									
BTBD1	53339	broad.mit.edu	37	15	83698894	83698894	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr15:83698894C>T	uc002bjn.2	-	5	1252	c.1049G>A	c.(1048-1050)CGA>CAA	p.R350Q	BTBD1_uc002bjo.2_Missense_Mutation_p.R350Q	NM_025238	NP_079514	Q9H0C5	BTBD1_HUMAN	BTB (POZ) domain containing 1 isoform 1	350						cytoplasmic mRNA processing body|protein complex	protein binding			ovary(1)|central_nervous_system(1)	2				all cancers(203;0.000186)		ATACCTGATTCGATCACTCGT	0.448		NaN											0	0	0	0.00361	0	187	388									
BTBD1	53339	broad.mit.edu	37	15	83735836	83735836	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr15:83735836G>A	uc002bjn.2	-	1	271	c.68C>T	c.(67-69)GCG>GTG	p.A23V	BTBD1_uc002bjo.2_Missense_Mutation_p.A23V	NM_025238	NP_079514	Q9H0C5	BTBD1_HUMAN	BTB (POZ) domain containing 1 isoform 1	23						cytoplasmic mRNA processing body|protein complex	protein binding			ovary(1)|central_nervous_system(1)	2				all cancers(203;0.000186)		cggcggccccgcggggcccgg	0.582		NaN											0	0	0	0.009096	0	4	5									
MPG	4350	broad.mit.edu	37	16	135661	135661	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr16:135661G>A	uc002cfn.2	+	5	1100	c.782G>A	c.(781-783)CGG>CAG	p.R261Q	MPG_uc002cfm.2_Missense_Mutation_p.R244Q|MPG_uc002cfo.2_Missense_Mutation_p.R256Q|NPRL3_uc010uua.1_Intron|NPRL3_uc002cfp.1_Intron	NM_002434	NP_002425	P29372	3MG_HUMAN	N-methylpurine-DNA glycosylase isoform a	261					depurination|DNA dealkylation involved in DNA repair	nucleoplasm	alkylbase DNA N-glycosylase activity|damaged DNA binding|identical protein binding			ovary(1)|skin(1)	2		all_cancers(16;9.01e-08)|all_epithelial(16;7.64e-07)|Hepatocellular(780;0.000325)|Lung NSC(18;0.0104)|all_lung(18;0.0239)				GCAGCAGCCCGGGTGGGCGTC	0.657		NaN						BER_DNA_glycosylases					0	0	0	0.009096	0	4	6									
BTBD12	84464	broad.mit.edu	37	16	3639978	3639978	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr16:3639978C>A	uc002cvp.2	-	12	4288	c.3661G>T	c.(3661-3663)GCG>TCG	p.A1221S		NM_032444	NP_115820	Q8IY92	SLX4_HUMAN	BTB (POZ) domain containing 12	1221	Interaction with PLK1 and TERF2-TERF2IP.				DNA double-strand break processing involved in repair via single-strand annealing|double-strand break repair via homologous recombination|nucleotide-excision repair	Slx1-Slx4 complex	enzyme activator activity|protein binding				0						TCCGGCAGCGCCCCCTCATCC	0.607		NaN						Direct_reversal_of_damage|Homologous_recombination	Fanconi_Anemia				1	0	5.35267e-07	0.007413	5.46146e-07	17	45									
ERCC4	2072	broad.mit.edu	37	16	14021928	14021928	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr16:14021928G>A	uc002dce.2	+	4	637	c.628G>A	c.(628-630)GAA>AAA	p.E210K	ERCC4_uc010bva.2_Missense_Mutation_p.E210K	NM_005236	NP_005227	Q92889	XPF_HUMAN	excision repair cross-complementing rodent	210					double-strand break repair via homologous recombination|meiotic mismatch repair|negative regulation of telomere maintenance|nucleotide-excision repair, DNA damage removal|nucleotide-excision repair, DNA incision, 3'-to lesion|nucleotide-excision repair, DNA incision, 5'-to lesion|resolution of meiotic recombination intermediates|telomere maintenance via telomere shortening|transcription-coupled nucleotide-excision repair	nuclear chromosome, telomeric region|nucleoplasm|nucleotide-excision repair factor 1 complex	damaged DNA binding|protein C-terminus binding|protein N-terminus binding|single-stranded DNA binding|single-stranded DNA specific endodeoxyribonuclease activity			lung(4)|ovary(3)|skin(2)|pancreas(1)	10						GCACAAACCTGAAGTTGTAGA	0.343		NaN	Mis|N|F			skin basal cell|skin squamous cell|melanoma		Direct_reversal_of_damage|NER	Xeroderma_Pigmentosum				0	0	0	0.007835	0	29	77									
TAOK2	9344	broad.mit.edu	37	16	29996729	29996729	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr16:29996729G>A	uc002dva.1	+	14	2401	c.1618G>A	c.(1618-1620)GAA>AAA	p.E540K	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|TAOK2_uc002dvb.1_Missense_Mutation_p.E540K|TAOK2_uc002dvc.1_Missense_Mutation_p.E540K|TAOK2_uc010bzm.1_Missense_Mutation_p.E547K|TAOK2_uc002dvd.1_Missense_Mutation_p.E367K	NM_016151	NP_057235	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 2	540	Potential.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						GGCAGAGGCAGAAAAGCTGGC	0.672		NaN											0	0	0	0.000602	0	5	6									
ZNF267	10308	broad.mit.edu	37	16	31927296	31927296	+	Missense_Mutation	SNP	T	T	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr16:31927296T>C	uc002ecs.3	+	4	1935	c.1726T>C	c.(1726-1728)TAC>CAC	p.Y576H		NM_003414	NP_003405	Q14586	ZN267_HUMAN	zinc finger protein 267	576	C2H2-type 10.				multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|breast(1)|skin(1)	4						AGAAAAACCATACAAATGTAA	0.383		NaN											0	0	0	0.006122	0	14	42									
MYLK3	91807	broad.mit.edu	37	16	46771856	46771856	+	Silent	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr16:46771856C>T	uc002eei.3	-	3	884	c.768G>A	c.(766-768)GAG>GAA	p.E256E	MYLK3_uc010vge.1_Intron|MYLK3_uc002eej.1_5'UTR	NM_182493	NP_872299	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	256					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			stomach(2)|skin(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	7		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				TCCTGAGGTTCTCGCTGGGTG	0.647		NaN											0	0	0	0.001368	0	11	42									
MYLK3	91807	broad.mit.edu	37	16	46772020	46772020	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr16:46772020C>T	uc002eei.3	-	3	720	c.604G>A	c.(604-606)GAG>AAG	p.E202K	MYLK3_uc010vge.1_Intron|MYLK3_uc002eej.1_5'UTR	NM_182493	NP_872299	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	202					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			stomach(2)|skin(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	7		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				GGCAGCCTCTCCGCTGTCCCC	0.637		NaN											0	0	0	0.00308	0	6	13									
MYLK3	91807	broad.mit.edu	37	16	46773969	46773969	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr16:46773969C>T	uc002eei.3	-	2	684	c.568G>A	c.(568-570)GAG>AAG	p.E190K	MYLK3_uc010vge.1_5'UTR|MYLK3_uc002eej.1_5'Flank	NM_182493	NP_872299	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	190					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			stomach(2)|skin(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	7		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				TCCCACTCACCTTCCCCAGGC	0.502		NaN											0	0	0	0.00333	0	12	155									
MYLK3	91807	broad.mit.edu	37	16	46773981	46773981	+	Missense_Mutation	SNP	C	C	T	rs55813660		TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr16:46773981C>T	uc002eei.3	-	2	672	c.556G>A	c.(556-558)GAG>AAG	p.E186K	MYLK3_uc010vge.1_5'UTR|MYLK3_uc002eej.1_5'Flank	NM_182493	NP_872299	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	186					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			stomach(2)|skin(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	7		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				TCCCCAGGCTCCCTGGCATCA	0.473		NaN											0	0	0	0.003954	0	12	165									
CDH11	1009	broad.mit.edu	37	16	64981662	64981662	+	Nonsense_Mutation	SNP	A	A	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr16:64981662A>C	uc002eoi.2	-	13	2669	c.2235T>G	c.(2233-2235)TAT>TAG	p.Y745*	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_3'UTR|CDH11_uc010vin.1_Nonsense_Mutation_p.Y619*	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	745	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		CCCTGCCTTCATAACCGTAGA	0.527		NaN	T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			0	0	0	0.008871	0	16	57									
C16orf55	124045	broad.mit.edu	37	16	89735693	89735693	+	Splice_Site	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr16:89735693G>C	uc002fnw.1	+	3	209	c.209_splice	c.e3-1	p.E70_splice	C16orf55_uc010vpk.1_Splice_Site_p.E71_splice|C16orf55_uc002fny.1_Splice_Site	NM_153025	NP_694570	Q96N06	CP055_HUMAN	hypothetical protein LOC124045												0		all_lung(18;0.000665)|all_hematologic(23;0.0355)		BRCA - Breast invasive adenocarcinoma(80;0.0274)		TTTTCCTCTAGAGAAACCTGA	0.458		NaN											0	0	0	0.004482	0	8	32									
TP53	7157	broad.mit.edu	37	17	7577538	7577538	+	Missense_Mutation	SNP	C	C	T	rs11540652		TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr17:7577538C>T	uc002gim.2	-	7	937	c.743G>A	c.(742-744)CGG>CAG	p.R248Q	TP53_uc002gig.1_Missense_Mutation_p.R248Q|TP53_uc002gih.2_Missense_Mutation_p.R248Q|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116Q|TP53_uc010cng.1_Missense_Mutation_p.R116Q|TP53_uc002gii.1_Missense_Mutation_p.R116Q|TP53_uc010cnh.1_Missense_Mutation_p.R248Q|TP53_uc010cni.1_Missense_Mutation_p.R248Q|TP53_uc002gij.2_Missense_Mutation_p.R248Q|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155Q|TP53_uc002gio.2_Missense_Mutation_p.R116Q	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(523)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.R155Q(4)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIN87_STOMACH)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NIHOVCAR3_OVARY)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(HCC70_BREAST)|R248Q(KYSE150_OESOPHAGUS)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PC14_LUNG)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.00361	0	54	16									
MYH10	4628	broad.mit.edu	37	17	8379127	8379127	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr17:8379127C>G	uc002gll.2	-	41	6022	c.5926G>C	c.(5926-5928)GAG>CAG	p.E1976Q	MYH10_uc002glm.2_Missense_Mutation_p.E2007Q|MYH10_uc010cnx.2_Missense_Mutation_p.E1985Q	NM_005964	NP_005955	P35580	MYH10_HUMAN	myosin, heavy polypeptide 10, non-muscle	1976	Potential.				actin filament-based movement|axon guidance|cytokinesis after mitosis|regulation of cell shape	cell cortex|cleavage furrow|midbody|myosin complex|stress fiber	actin filament binding|actin-dependent ATPase activity|ADP binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(2)	2						CAACTTTACTCTGACTGGGGT	0.562		NaN											0	0	0	0.00361	0	151	67									
SUZ12	23512	broad.mit.edu	37	17	30323833	30323833	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr17:30323833C>G	uc002hgs.2	+	15	2033	c.1811C>G	c.(1810-1812)TCT>TGT	p.S604C	SUZ12_uc002hgt.2_Missense_Mutation_p.S581C	NM_015355	NP_056170	Q15022	SUZ12_HUMAN	joined to JAZF1	604	VEFS-box.				negative regulation of cell differentiation|transcription, DNA-dependent	ESC/E(Z) complex	histone methyltransferase activity|methylated histone residue binding|zinc ion binding		JAZF1/SUZ12(131)	soft_tissue(98)|endometrium(33)	131		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.041)|Ovarian(249;0.182)|Breast(31;0.231)				GAAGAGTTTTCTGATGTTAAT	0.294		NaN	T	JAZF1	endometrial stromal tumours								0	0	0	0.00361	0	38	32									
GAS2L2	246176	broad.mit.edu	37	17	34077315	34077315	+	Silent	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr17:34077315C>T	uc002hjv.1	-	2	436	c.408G>A	c.(406-408)GAG>GAA	p.E136E		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	136	CH.				cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GCACCAAGTCCTCCGTCTCGA	0.662		NaN											0	0	0	0.00632	0	27	260									
GAS2L2	246176	broad.mit.edu	37	17	34079717	34079717	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr17:34079717G>T	uc002hjv.1	-	1	181	c.153C>A	c.(151-153)GAC>GAA	p.D51E		NM_139285	NP_644814	Q8NHY3	GA2L2_HUMAN	growth arrest-specific 2 like 2	51	CH.				cell cycle arrest	cytoplasm|cytoskeleton				ovary(1)|skin(1)	2		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		AGTTGGCTGCGTCGATGTCCA	0.607		NaN											1	0	4.09166e-32	0.00361	4.44592e-32	60	87									
ACACA	31	broad.mit.edu	37	17	35615271	35615271	+	Silent	SNP	T	T	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr17:35615271T>G	uc002hnm.2	-	13	1605	c.1414A>C	c.(1414-1416)AGA>CGA	p.R472R	ACACA_uc002hnk.2_Silent_p.R394R|ACACA_uc002hnl.2_Silent_p.R414R|ACACA_uc002hnn.2_Silent_p.R472R|ACACA_uc002hno.2_Silent_p.R509R|ACACA_uc010cuz.2_Silent_p.R472R	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	472	Biotin carboxylation.				acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	TCCTTGATTCTATATAGAGGA	0.403		NaN											0	0	0	0.009535	0	23	110									
ERBB2	2064	broad.mit.edu	37	17	37868200	37868200	+	Silent	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr17:37868200C>T	uc002hso.2	+	8	1159	c.921C>T	c.(919-921)GAC>GAT	p.D307D	ERBB2_uc002hsm.2_Silent_p.D277D|ERBB2_uc010cwa.2_Silent_p.D292D|ERBB2_uc002hsp.2_Silent_p.D110D|ERBB2_uc010cwb.2_Silent_p.D307D|ERBB2_uc010wek.1_Silent_p.D31D|ERBB2_uc002hsl.2_Silent_p.D277D|ERBB2_uc002hsn.1_Silent_p.D307D	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	307	Extracellular (Potential).				cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity			lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	TTTCTACGGACGTGGGATCCT	0.577		1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			0	0	0	0.010729	0	9	949									
TUBG2	27175	broad.mit.edu	37	17	40817733	40817733	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr17:40817733G>A	uc010wgr.1	+	8	987	c.731G>A	c.(730-732)CGC>CAC	p.R244H	TUBG2_uc002iaq.2_Missense_Mutation_p.R86H|TUBG2_uc002iar.2_Missense_Mutation_p.R91H|TUBG2_uc002ias.2_Missense_Mutation_p.R86H|TUBG2_uc002iap.2_Missense_Mutation_p.R91H	NM_016437	NP_057521	Q9NRH3	TBG2_HUMAN	tubulin, gamma 2	244					G2/M transition of mitotic cell cycle|microtubule-based process|protein polymerization	cytosol	GTP binding|GTPase activity|structural molecule activity			ovary(1)	1		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.141)		ACCACCCTGCGCTACCCCGGC	0.637		NaN											0	0	0	0.00361	0	78	162									
VAT1	10493	broad.mit.edu	37	17	41168155	41168155	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr17:41168155C>T	uc002icm.1	-	6	1225	c.1105G>A	c.(1105-1107)GAT>AAT	p.D369N	VAT1_uc010cyw.1_Missense_Mutation_p.D235N|VAT1_uc010whk.1_Missense_Mutation_p.D301N	NM_006373	NP_006364	Q99536	VAT1_HUMAN	vesicle amine transport protein 1	369						cytoplasm|integral to membrane	oxidoreductase activity|zinc ion binding				0		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.156)		TTCATGGCATCAGCCACCTGG	0.567		NaN											0	0	0	0.008291	0	9	424									
BCAS3	54828	broad.mit.edu	37	17	59152341	59152341	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr17:59152341C>T	uc002iyv.3	+	21	2244	c.2135C>T	c.(2134-2136)TCT>TTT	p.S712F	BCAS3_uc002iyu.3_Missense_Mutation_p.S697F|BCAS3_uc002iyw.3_Missense_Mutation_p.S693F|BCAS3_uc002iyy.3_Missense_Mutation_p.S468F|BCAS3_uc002iyz.3_Missense_Mutation_p.S266F|BCAS3_uc002iza.3_Missense_Mutation_p.S251F	NM_001099432	NP_001092902	Q9H6U6	BCAS3_HUMAN	breast carcinoma amplified sequence 3 isoform 1	712						nucleus				ovary(2)|central_nervous_system(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(1;3.11e-12)|Epithelial(12;8.2e-07)|all cancers(12;5.33e-06)			AGTTTAGCTTCTGACCATAGT	0.378		NaN											0	0	0	0.00361	0	64	112									
ABCA8	10351	broad.mit.edu	37	17	66899519	66899519	+	Silent	SNP	G	G	A	rs144614574		TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr17:66899519G>A	uc002jhp.2	-	18	2579	c.2400C>T	c.(2398-2400)CTC>CTT	p.L800L	ABCA8_uc002jhq.2_Silent_p.L840L|ABCA8_uc010wqq.1_Silent_p.L840L|ABCA8_uc010wqr.1_Silent_p.L779L|ABCA8_uc002jhr.2_Silent_p.L840L	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8	800						integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					GCTGTCGCCAGAGAGCCACAC	0.433		NaN											0	0	0	0.00361	0	69	133									
DSG2	1829	broad.mit.edu	37	18	29125912	29125912	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr18:29125912C>A	uc002kwu.3	+	15	2751	c.2563C>A	c.(2563-2565)CAA>AAA	p.Q855K	uc002kwv.3_Intron	NM_001943	NP_001934	Q14126	DSG2_HUMAN	desmoglein 2 preproprotein	855	Cytoplasmic (Potential).				cellular component disassembly involved in apoptosis|homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(2)|breast(1)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(10;0.0068)			TGAGCAGAGACAAAAACCTGC	0.388		NaN											1	0	0.000566183	0.00499	0.000573032	4	95									
C18orf34	374864	broad.mit.edu	37	18	30804901	30804901	+	Splice_Site	SNP	C	C	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr18:30804901C>G	uc002kxn.2	-	16	1799	c.1657_splice	c.e16-1	p.K553_splice	C18orf34_uc010dme.1_Splice_Site_p.K67_splice|C18orf34_uc010xbr.1_Splice_Site_p.K553_splice|C18orf34_uc010dmf.1_Intron|C18orf34_uc002kxo.2_Splice_Site_p.K553_splice|C18orf34_uc002kxp.2_Splice_Site_p.K553_splice	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1											ovary(1)	1						ATAGTTTTTTCTGCCAGCAAA	0.328		NaN											0	0	0	0.004007	0	13	50									
SEC11C	90701	broad.mit.edu	37	18	56816747	56816747	+	Silent	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr18:56816747C>T	uc002lht.2	+	2	146	c.90C>T	c.(88-90)CTC>CTT	p.L30L	SEC11C_uc010dpo.1_Silent_p.L30L|SEC11C_uc010xej.1_Silent_p.L30L	NM_033280	NP_150596	Q9BY50	SC11C_HUMAN	SEC11-like 3	30	Helical; Signal-anchor for type II membrane protein; (Potential).				energy reserve metabolic process|regulation of insulin secretion|signal peptide processing	endoplasmic reticulum membrane|integral to membrane|microsome	serine-type peptidase activity				0		Colorectal(73;0.175)				CATTCCAGCTCTATTACCAGG	0.448		NaN											0	0	0	0.00361	0	59	57									
ZCCHC2	54877	broad.mit.edu	37	18	60241918	60241918	+	Silent	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr18:60241918C>T	uc002lip.3	+	13	2604	c.2604C>T	c.(2602-2604)ATC>ATT	p.I868I	ZCCHC2_uc002lio.2_RNA|ZCCHC2_uc002liq.2_Silent_p.I338I	NM_017742	NP_060212	Q9C0B9	ZCHC2_HUMAN	zinc finger, CCHC domain containing 2	868					cell communication	cytoplasm	nucleic acid binding|phosphatidylinositol binding|zinc ion binding			lung(1)|prostate(1)	2						CGGACCCCATCACAAAATCTG	0.507		NaN											0	0	0	0.004878	0	33	117									
VPS4B	9525	broad.mit.edu	37	18	61058250	61058250	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr18:61058250C>G	uc002lix.2	-	11	1553	c.1293G>C	c.(1291-1293)TTG>TTC	p.L431F		NM_004869	NP_004860	O75351	VPS4B_HUMAN	vacuolar protein sorting factor 4B	431					cell cycle|cell division|cellular membrane organization|endosome to lysosome transport via multivesicular body sorting pathway|intracellular cholesterol transport|protein transport|response to lipid	cytosol|early endosome|late endosome membrane|lysosome|nucleus|vacuolar membrane	ATP binding|ATPase activity, coupled|protein C-terminus binding			ovary(1)	1						TCTTTAATTTCAACAAGTCAT	0.353		NaN											0	0	0	0.012213	0	24	39									
C19orf26	255057	broad.mit.edu	37	19	1231042	1231042	+	Silent	SNP	C	C	A	rs75463186		TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr19:1231042C>A	uc002lrm.2	-	9	1469	c.1194G>T	c.(1192-1194)TCG>TCT	p.S398S		NM_152769	NP_689982	Q8N350	DOS_HUMAN	downstream of Stk11	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment						integral to membrane					0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TAGGGGGGGGCGAAGGGGGGC	0.716		NaN								HNSCC(14;0.022)			1	0	2.0095e-06	0.001984	2.04204e-06	6	28									
MUC16	94025	broad.mit.edu	37	19	9071151	9071151	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr19:9071151G>C	uc002mkp.2	-	3	16499	c.16295C>G	c.(16294-16296)TCT>TGT	p.S5432C		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5434	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TTTATGTCCAGACCCGGAAGT	0.522		NaN											0	0	0	0.001984	0	6	369									
MUC16	94025	broad.mit.edu	37	19	9076312	9076312	+	Missense_Mutation	SNP	T	T	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr19:9076312T>C	uc002mkp.2	-	3	11338	c.11134A>G	c.(11134-11136)ACA>GCA	p.T3712A		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	3713	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GCATGATCTGTAGAAACCATT	0.458		NaN											0	0	0	0.004878	0	32	123									
CARM1	10498	broad.mit.edu	37	19	11031771	11031771	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr19:11031771C>G	uc002mpz.2	+	14	1709	c.1583C>G	c.(1582-1584)TCC>TGC	p.S528C	CARM1_uc010dxn.2_RNA|CARM1_uc002mqa.2_Missense_Mutation_p.S311C	NM_199141	NP_954592	Q86X55	CARM1_HUMAN	coactivator-associated arginine	528	Transactivation domain (By similarity).				cellular lipid metabolic process|histone H3-R2 methylation|interspecies interaction between organisms|pathogenesis|positive regulation of fat cell differentiation|regulation of estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleoplasm	beta-catenin binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-R17 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein-arginine omega-N asymmetric methyltransferase activity|transcription regulatory region DNA binding				0						GCCAGTGGCTCCAGCGTGGGC	0.662		NaN											0	0	0	0.003163	0	11	44									
BEST2	54831	broad.mit.edu	37	19	12864153	12864153	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr19:12864153G>C	uc002mux.2	+	2	232	c.232G>C	c.(232-234)GTC>CTC	p.V78L		NM_017682	NP_060152	Q8NFU1	BEST2_HUMAN	vitelliform macular dystrophy 2-like 1	78	Helical; (Potential).				membrane depolarization|sensory perception of smell	chloride channel complex|cilium|plasma membrane	chloride channel activity			ovary(1)|pancreas(1)	2						CCTCATCCCTGTCTCCTTCGT	0.552		NaN											0	0	0	0.00278	0	20	124									
ZNF257	113835	broad.mit.edu	37	19	22271633	22271633	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr19:22271633C>G	uc010ecx.2	+	4	1250	c.1081C>G	c.(1081-1083)CAA>GAA	p.Q361E	ZNF257_uc010ecy.2_Missense_Mutation_p.Q329E	NM_033468	NP_258429	Q9Y2Q1	ZN257_HUMAN	zinc finger protein 257	361	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.0961)|Lung NSC(12;0.103)				ACACCTTACTCAACATAAGAT	0.398		NaN											0	0	0	0.006122	0	13	37									
SIPA1L3	23094	broad.mit.edu	37	19	38655151	38655151	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr19:38655151C>G	uc002ohk.2	+	15	4322	c.3813C>G	c.(3811-3813)AGC>AGG	p.S1271R		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	1271					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			ATTCCAGCAGCAACACCCTCT	0.622		NaN											0	0	0	0.00361	0	72	139									
HNRNPUL1	11100	broad.mit.edu	37	19	41782119	41782119	+	Silent	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr19:41782119C>T	uc002oqb.3	+	5	991	c.702C>T	c.(700-702)CTC>CTT	p.L234L	CYP2F1_uc010xvw.1_Intron|HNRNPUL1_uc002opz.3_Silent_p.L134L|HNRNPUL1_uc002oqa.3_Silent_p.L134L|HNRNPUL1_uc010ehm.2_Silent_p.L234L|HNRNPUL1_uc002oqc.3_Silent_p.L191L|HNRNPUL1_uc002oqe.3_Intron|HNRNPUL1_uc002oqd.3_Silent_p.L134L|HNRNPUL1_uc010ehn.2_Silent_p.L134L|HNRNPUL1_uc010eho.2_Silent_p.L134L|HNRNPUL1_uc010xvy.1_Silent_p.L134L|HNRNPUL1_uc010ehp.2_Silent_p.L90L|HNRNPUL1_uc010ehl.1_Silent_p.L134L	NM_007040	NP_008971	Q9BUJ2	HNRL1_HUMAN	heterogeneous nuclear ribonucleoprotein U-like 1	234	B30.2/SPRY.|Necessary for interaction with TP53.				nuclear mRNA splicing, via spliceosome|regulation of transcription, DNA-dependent|response to virus|transcription, DNA-dependent	heterogeneous nuclear ribonucleoprotein complex|nucleoplasm	enzyme binding|RNA binding			central_nervous_system(1)|skin(1)	2						GCTATCCGCTCACAATTGAGG	0.512		NaN											0	0	0	0.00361	0	101	138									
PPP5C	5536	broad.mit.edu	37	19	46888119	46888119	+	Missense_Mutation	SNP	T	T	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr19:46888119T>C	uc002pem.2	+	7	917	c.857T>C	c.(856-858)CTT>CCT	p.L286P	PPP5C_uc010xya.1_Missense_Mutation_p.L153P|PPP5C_uc002pen.2_Missense_Mutation_p.L264P|PPP5C_uc010xyb.1_Missense_Mutation_p.L144P	NM_006247	NP_006238	P53041	PPP5_HUMAN	protein phosphatase 5, catalytic subunit	286	Catalytic.				mitosis|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein dephosphorylation|transcription, DNA-dependent	Golgi apparatus|nucleus	metal ion binding|protein binding|protein serine/threonine phosphatase activity|signal transducer activity			lung(1)|pancreas(1)	2		Ovarian(192;0.0731)|all_neural(266;0.196)		OV - Ovarian serous cystadenocarcinoma(262;0.000196)|all cancers(93;0.00192)|GBM - Glioblastoma multiforme(486;0.0499)|Epithelial(262;0.0504)		ATCCTCACCCTTTTCGGCTTC	0.527		NaN											0	0	0	0.000602	0	3	139									
ZNF83	55769	broad.mit.edu	37	19	53116283	53116283	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr19:53116283G>C	uc002pzu.3	-	2	2779	c.1535C>G	c.(1534-1536)TCT>TGT	p.S512C	ZNF83_uc002pzv.3_Missense_Mutation_p.S512C|ZNF83_uc010eps.2_Missense_Mutation_p.S484C|ZNF83_uc010ept.2_Missense_Mutation_p.S512C|ZNF83_uc010epu.2_Missense_Mutation_p.S512C|ZNF83_uc010epv.2_Missense_Mutation_p.S512C|ZNF83_uc010epw.2_Missense_Mutation_p.S512C|ZNF83_uc010epx.2_Missense_Mutation_p.S484C|ZNF83_uc010epy.2_Missense_Mutation_p.S512C|ZNF83_uc010epz.2_Missense_Mutation_p.S484C	NM_018300	NP_060770	P51522	ZNF83_HUMAN	zinc finger protein 83 isoform a	512						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.00841)|GBM - Glioblastoma multiforme(134;0.0244)		ACATGTGTTAGATTTCTTTCC	0.348		NaN											0	0	0	0.00361	0	44	75									
ZNF71	58491	broad.mit.edu	37	19	57133450	57133450	+	Silent	SNP	C	C	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr19:57133450C>G	uc002qnm.3	+	3	1033	c.795C>G	c.(793-795)ACC>ACG	p.T265T		NM_021216	NP_067039	Q9NQZ8	ZNF71_HUMAN	zinc finger protein 71	265						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(1)	1				GBM - Glioblastoma multiforme(193;0.062)|Lung(386;0.0681)|LUSC - Lung squamous cell carcinoma(496;0.18)		GCACGCACACCGGGGAGAAGC	0.672		NaN											0	0	0	0.010504	0	20	94									
ZNF749	388567	broad.mit.edu	37	19	57955885	57955885	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr19:57955885C>G	uc002qoq.2	+	3	1623	c.1369C>G	c.(1369-1371)CAG>GAG	p.Q457E	ZNF547_uc002qpm.3_Intron	NM_001023561	NP_001018855	O43361	ZN749_HUMAN	zinc finger protein 749	457	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)|Lung(386;0.177)		AGTTCAGCACCAGAAAATCCA	0.423		NaN											0	0	0	0.009096	0	3	151									
GEN1	348654	broad.mit.edu	37	2	17961316	17961316	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr2:17961316G>C	uc002rct.2	+	13	1409	c.1336G>C	c.(1336-1338)GAA>CAA	p.E446Q	SMC6_uc010exo.2_Intron|GEN1_uc010yjs.1_Missense_Mutation_p.E446Q|GEN1_uc002rcu.2_Missense_Mutation_p.E446Q	NM_182625	NP_872431	Q17RS7	GEN_HUMAN	Gen homolog 1, endonuclease	446					DNA repair	nucleus	DNA binding|endonuclease activity|metal ion binding			breast(5)|kidney(1)|central_nervous_system(1)|skin(1)	8	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					ATCATTGTTTGAAGCAGCATA	0.303		NaN						Homologous_recombination					0	0	0	0.00361	0	52	6									
PUM2	23369	broad.mit.edu	37	2	20508104	20508104	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr2:20508104C>G	uc002rds.1	-	5	783	c.760G>C	c.(760-762)GGC>CGC	p.G254R	PUM2_uc002rdt.1_Missense_Mutation_p.G254R|PUM2_uc002rdr.2_Missense_Mutation_p.G193R|PUM2_uc010yjy.1_Missense_Mutation_p.G254R|PUM2_uc002rdu.1_Missense_Mutation_p.G254R|PUM2_uc010yjz.1_Missense_Mutation_p.G193R	NM_015317	NP_056132	Q8TB72	PUM2_HUMAN	pumilio homolog 2	254	Interaction with SNAPIN.				regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCAAAAAGGCCTACAGTAGCT	0.433		NaN											0	0	0	0.00361	0	111	22									
XPO1	7514	broad.mit.edu	37	2	61706062	61706062	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr2:61706062C>G	uc002sbj.2	-	25	3837	c.3109G>C	c.(3109-3111)GAG>CAG	p.E1037Q	XPO1_uc010fcl.2_Missense_Mutation_p.E1033Q|XPO1_uc010ypn.1_Missense_Mutation_p.E1033Q|XPO1_uc002sbk.2_Missense_Mutation_p.E598Q|XPO1_uc002sbg.2_Missense_Mutation_p.E234Q|XPO1_uc002sbh.2_Missense_Mutation_p.E684Q	NM_003400	NP_003391	O14980	XPO1_HUMAN	exportin 1	1037	HEAT 10.				intracellular protein transport|mitotic prometaphase|mRNA metabolic process|mRNA transport|viral genome transport in host cell|viral infectious cycle	annulate lamellae|Cajal body|cytosol|kinetochore|nuclear envelope|nucleolus|ribonucleoprotein complex	protein binding|protein transporter activity|RNA binding			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)|skin(1)	4			LUSC - Lung squamous cell carcinoma(7;5.71e-05)|Epithelial(17;0.0662)|all cancers(80;0.226)			ATTTCTCTCTCTTCCAAAAAC	0.388		NaN											0	0	0	0.00361	0	52	44									
STARD7	56910	broad.mit.edu	37	2	96859074	96859074	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr2:96859074C>G	uc002svm.3	-	4	967	c.566G>C	c.(565-567)AGA>ACA	p.R189T	STARD7_uc002svl.2_5'UTR	NM_020151	NP_064536	Q9NQZ5	STAR7_HUMAN	START domain containing 7 precursor	189	START.					mitochondrion					0						CCATTTTTTTCTATACTCTGT	0.443		NaN											0	0	0	0.00361	0	43	95									
BUB1	699	broad.mit.edu	37	2	111413469	111413469	+	Missense_Mutation	SNP	A	A	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr2:111413469A>C	uc002tgc.2	-	16	1835	c.1723T>G	c.(1723-1725)TTT>GTT	p.F575V	BUB1_uc010yxh.1_Missense_Mutation_p.F555V|BUB1_uc010fkb.2_Missense_Mutation_p.F575V	NM_004336	NP_004327	O43683	BUB1_HUMAN	budding uninhibited by benzimidazoles 1	575					apoptosis|cell division|chromosome segregation|interspecies interaction between organisms|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|regulation of sister chromatid cohesion	condensed chromosome kinetochore|cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			lung(2)|breast(2)|stomach(1)|ovary(1)|kidney(1)	7		Ovarian(717;0.0822)		BRCA - Breast invasive adenocarcinoma(221;0.0556)		TCATCCAAAAACTCTTCAGCA	0.438		NaN											0	0	0	0.004482	0	7	228									
MYO7B	4648	broad.mit.edu	37	2	128389955	128389955	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr2:128389955G>A	uc002top.2	+	38	5359	c.5306G>A	c.(5305-5307)CGC>CAC	p.R1769H	MYO7B_uc002tos.1_5'Flank|MYO7B_uc002tot.2_5'Flank	NM_001080527	NP_001073996	Q6PIF6	MYO7B_HUMAN	myosin VIIB	1769	MyTH4 2.					apical plasma membrane|myosin complex	actin binding|ATP binding|motor activity			ovary(1)|pancreas(1)	2	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0753)		GACTGCAGCCGCCGAATCCAG	0.682		NaN											0	0	0	0.006999	0	31	79									
MBD5	55777	broad.mit.edu	37	2	149226442	149226442	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr2:149226442G>C	uc002twm.3	+	9	1918	c.930G>C	c.(928-930)ATG>ATC	p.M310I	MBD5_uc010zbs.1_RNA|MBD5_uc010fns.2_Missense_Mutation_p.M310I|MBD5_uc002twn.1_5'Flank	NM_018328	NP_060798	Q9P267	MBD5_HUMAN	methyl-CpG binding domain protein 5	310						chromosome|nucleus	chromatin binding|DNA binding			skin(3)|ovary(2)	5				BRCA - Breast invasive adenocarcinoma(221;0.0569)		GTCCAGTAATGAAAAAACCAA	0.448		NaN											0	0	0	0.004656	0	23	73									
TTN	7273	broad.mit.edu	37	2	179411950	179411950	+	Silent	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr2:179411950G>A	uc010zfg.1	-	289	86822	c.86598C>T	c.(86596-86598)CAC>CAT	p.H28866H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.H22561H|TTN_uc010zfi.1_Silent_p.H22494H|TTN_uc010zfj.1_Silent_p.H22369H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	29793							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGCCACCATCGTGGTAGGGTT	0.443		NaN											0	0	0	0.004482	0	8	225									
TTN	7273	broad.mit.edu	37	2	179556797	179556797	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr2:179556797C>G	uc010zfg.1	-	118	28200	c.27976G>C	c.(27976-27978)GAG>CAG	p.E9326Q	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.E5987Q|TTN_uc010fre.1_Missense_Mutation_p.E437Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	10253							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTTTTCTCCTCTGGCACGGGT	0.453		NaN											0	0	0	0.001855	0	12	35									
TTN	7273	broad.mit.edu	37	2	179582433	179582433	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr2:179582433G>A	uc010zfg.1	-	84	21660	c.21436C>T	c.(21436-21438)CAA>TAA	p.Q7146*	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Nonsense_Mutation_p.Q3807*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	8073							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CAAGACACTTGAAGAGGTTCT	0.398		NaN											0	0	0	0.003163	0	14	17									
TTN	7273	broad.mit.edu	37	2	179590304	179590304	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr2:179590304G>T	uc010zfg.1	-	68	17119	c.16895C>A	c.(16894-16896)TCC>TAC	p.S5632Y	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.S2293Y	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6559							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GCCTTCTATGGATGCTTGTAA	0.423		NaN											1	0	1.66031e-10	0.003954	1.71497e-10	25	29									
SP100	6672	broad.mit.edu	37	2	231281027	231281027	+	Missense_Mutation	SNP	G	G	A	rs151275724	by1000genomes	TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr2:231281027G>A	uc002vqt.2	+	1	157	c.16G>A	c.(16-18)GGC>AGC	p.G6S	SP100_uc002vqs.2_Missense_Mutation_p.G6S|SP100_uc002vqu.1_Missense_Mutation_p.G6S|SP100_uc010zmb.1_Missense_Mutation_p.G6S|SP100_uc002vqq.1_Missense_Mutation_p.G6S|SP100_uc002vqr.1_Missense_Mutation_p.G6S|SP100_uc010zmc.1_Missense_Mutation_p.G6S|SP100_uc002vqv.1_5'Flank	NM_003113	NP_003104	P23497	SP100_HUMAN	nuclear antigen Sp100 isoform 2	6	Poly-Gly.				DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|interspecies interaction between organisms|negative regulation of cellular component movement|negative regulation of DNA binding|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|negative regulation of transcription, DNA-dependent|negative regulation of viral transcription|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|response to cytokine stimulus|response to retinoic acid|response to type I interferon	cytoplasm|nuclear periphery|nucleolus|PML body	chromo shadow domain binding|DNA binding|identical protein binding|kinase binding|protein homodimerization activity|transcription coactivator activity|transcription corepressor activity|transcription factor binding			ovary(4)|central_nervous_system(1)	5		Renal(207;0.0112)|all_lung(227;0.0335)|all_hematologic(139;0.0749)|Lung NSC(271;0.142)|Acute lymphoblastic leukemia(138;0.167)		Epithelial(121;1.13e-12)|all cancers(144;2.71e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00942)		AGGTGGGGGCGGCGACCTGAG	0.592		NaN											0	0	0	0.004482	0	6	23									
FARP2	9855	broad.mit.edu	37	2	242433449	242433449	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr2:242433449G>A	uc002wbi.1	+	27	3191	c.3074G>A	c.(3073-3075)AGC>AAC	p.S1025N		NM_014808	NP_055623	O94887	FARP2_HUMAN	FERM, RhoGEF and pleckstrin domain protein 2	1025	PH 2.				axon guidance|neuron remodeling|Rac protein signal transduction|regulation of Rho protein signal transduction	cytoskeleton|cytosol|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			upper_aerodigestive_tract(1)|ovary(1)|skin(1)	3		all_cancers(19;4.88e-34)|all_epithelial(40;4.81e-14)|Breast(86;0.000141)|Renal(207;0.0143)|all_lung(227;0.0344)|Lung NSC(271;0.0886)|Ovarian(221;0.0905)|Esophageal squamous(248;0.131)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;1.81e-33)|all cancers(36;1.61e-30)|OV - Ovarian serous cystadenocarcinoma(60;6.83e-15)|Kidney(56;1.19e-08)|KIRC - Kidney renal clear cell carcinoma(57;8.98e-08)|BRCA - Breast invasive adenocarcinoma(100;1.49e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00125)|Colorectal(34;0.0199)|COAD - Colon adenocarcinoma(134;0.121)		CAGGGGGCCAGCAGCTCAGCC	0.632		NaN											0	0	0	0.009535	0	30	65									
RALGAPA2	57186	broad.mit.edu	37	20	20506951	20506951	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr20:20506951G>C	uc002wrz.2	-	28	3781	c.3638C>G	c.(3637-3639)TCC>TGC	p.S1213C	RALGAPA2_uc010gcx.2_Missense_Mutation_p.S917C|RALGAPA2_uc010zsg.1_Missense_Mutation_p.S661C|RALGAPA2_uc002wsa.1_5'UTR	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	1213					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						CTCCCAGTAGGAAACCAGCAA	0.408		NaN											0	0	0	0.001368	0	9	31									
ZNF337	26152	broad.mit.edu	37	20	25656896	25656896	+	Nonsense_Mutation	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr20:25656896G>C	uc002wva.2	-	4	1550	c.1028C>G	c.(1027-1029)TCA>TGA	p.S343*	uc002wuz.2_RNA|ZNF337_uc010ztg.1_Nonsense_Mutation_p.S311*|ZNF337_uc002wvb.2_Nonsense_Mutation_p.S343*|ZNF337_uc002wvc.2_Nonsense_Mutation_p.S343*	NM_015655	NP_056470	Q9Y3M9	ZN337_HUMAN	zinc finger protein 337	343					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTTCTCTCCTGAGTGTATTCT	0.498		NaN											0	0	0	0.003755	0	35	53									
NCOA6	23054	broad.mit.edu	37	20	33364214	33364214	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr20:33364214C>T	uc002xav.2	-	5	2844	c.273G>A	c.(271-273)TGG>TGA	p.W91*	NCOA6_uc002xaw.2_Nonsense_Mutation_p.W91*|NCOA6_uc010gew.1_Nonsense_Mutation_p.W91*	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	91	TBP/GTF2A-binding region.|NCOA1-binding region.|CREBBP-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						GCACGCTGTTCCAGGGCTCCA	0.473		NaN											0	0	0	0.013114	0	39	64									
PHF20	51230	broad.mit.edu	37	20	34526618	34526618	+	Splice_Site	SNP	G	G	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr20:34526618G>T	uc002xek.1	+	16	2412	c.2301_splice	c.e16-1	p.Q767_splice		NM_016436	NP_057520	Q9BVI0	PHF20_HUMAN	PHD finger protein 20						regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			ovary(1)	1	Breast(12;0.00631)|all_lung(11;0.0145)					CCTCTCAACAGAAGCCGGGAG	0.542		NaN											1	0	4.89347e-83	0.00361	5.38711e-83	148	247									
PHF20	51230	broad.mit.edu	37	20	34526935	34526935	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr20:34526935G>A	uc002xek.1	+	16	2728	c.2617G>A	c.(2617-2619)GAG>AAG	p.E873K		NM_016436	NP_057520	Q9BVI0	PHF20_HUMAN	PHD finger protein 20	873					regulation of transcription, DNA-dependent|transcription, DNA-dependent	MLL1 complex	DNA binding|zinc ion binding			ovary(1)	1	Breast(12;0.00631)|all_lung(11;0.0145)					CCCCCTCCATGAGAACGGCGA	0.632		NaN											0	0	0	0.006999	0	38	59									
TRAPPC10	7109	broad.mit.edu	37	21	45479022	45479022	+	Silent	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr21:45479022C>T	uc002zea.2	+	6	886	c.717C>T	c.(715-717)TTC>TTT	p.F239F	TRAPPC10_uc010gpo.2_5'UTR|TRAPPC10_uc002zdz.2_Silent_p.F239F	NM_003274	NP_003265	P48553	TPC10_HUMAN	trafficking protein particle complex 10	239					vesicle-mediated transport	Golgi apparatus|integral to membrane	binding|sodium ion transmembrane transporter activity			ovary(1)|skin(1)	2						TGCAGCAGTTCGAGGACGCCC	0.473		NaN											0	0	0	0.008361	0	22	51									
PCNT	5116	broad.mit.edu	37	21	47768968	47768968	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr21:47768968G>C	uc002zji.3	+	7	1182	c.1075G>C	c.(1075-1077)GAA>CAA	p.E359Q	PCNT_uc002zjj.2_Missense_Mutation_p.E241Q|PCNT_uc010gqk.1_RNA	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	359	Glu-rich.|Potential.				cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					TTTATGTTTAGAAAATCTACG	0.323		NaN											0	0	0	0.00361	0	41	112									
CECR2	27443	broad.mit.edu	37	22	17976513	17976513	+	Silent	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr22:17976513G>C	uc010gqw.1	+	2	300	c.174G>C	c.(172-174)CTG>CTC	p.L58L	CECR2_uc010gqv.1_5'UTR|CECR2_uc002zml.2_5'UTR|CECR2_uc002zmm.1_5'Flank	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	100					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)		CCAACCCTCTGAGGGAAGCCA	0.567		NaN											0	0	0	0.010504	0	20	93									
TRIOBP	11078	broad.mit.edu	37	22	38119384	38119384	+	Missense_Mutation	SNP	A	A	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr22:38119384A>C	uc003atr.2	+	7	1092	c.821A>C	c.(820-822)GAA>GCA	p.E274A	TRIOBP_uc003atu.2_Missense_Mutation_p.E102A|TRIOBP_uc003atq.1_Missense_Mutation_p.E274A|TRIOBP_uc003ats.1_Missense_Mutation_p.E102A	NM_001039141	NP_001034230	Q9H2D6	TARA_HUMAN	TRIO and F-actin binding protein isoform 6	274					actin modification|barbed-end actin filament capping	actin cytoskeleton|cytoplasm|nucleus	actin binding|GTP-Rho binding|myosin II binding|protein binding|ubiquitin protein ligase binding			central_nervous_system(1)	1	Melanoma(58;0.0574)					TCTACACGTGAAATCCCCAGA	0.592		NaN											0	0	0	0.012319	0	19	75									
POLDIP3	84271	broad.mit.edu	37	22	42999052	42999052	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr22:42999052C>G	uc003bcu.2	-	2	273	c.174G>C	c.(172-174)CAG>CAC	p.Q58H	POLDIP3_uc011app.1_5'UTR|POLDIP3_uc003bcv.2_Missense_Mutation_p.Q58H|POLDIP3_uc011apq.1_Missense_Mutation_p.Q58H|POLDIP3_uc010gza.2_RNA|POLDIP3_uc011apr.1_RNA|POLDIP3_uc010gzb.1_Missense_Mutation_p.Q58H	NM_032311	NP_115687	Q9BY77	PDIP3_HUMAN	DNA polymerase delta interacting protein 3	58					positive regulation of translation	cytoplasm|nuclear speck	nucleotide binding|protein binding|RNA binding				0						GGCCAATCTTCTGCCGGGCAT	0.557		NaN											0	0	0	0.00361	0	49	96									
PARVB	29780	broad.mit.edu	37	22	44532339	44532339	+	Splice_Site	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr22:44532339G>A	uc003ben.2	+	7	686	c.634_splice	c.e7-1	p.K212_splice	PARVB_uc003bem.2_Splice_Site_p.K245_splice|PARVB_uc010gzn.2_Splice_Site_p.K160_splice|PARVB_uc003beo.2_Splice_Site_p.K175_splice	NM_013327	NP_037459	Q9HBI1	PARVB_HUMAN	parvin, beta isoform b						cell adhesion|cell junction assembly	cytoskeleton|cytosol|focal adhesion	actin binding				0		Ovarian(80;0.0246)|all_neural(38;0.0423)				GGGGTTTTCAGAAACGGGAAG	0.542		NaN											0	0	0	0.005443	0	25	69									
HDAC10	83933	broad.mit.edu	37	22	50686355	50686355	+	Missense_Mutation	SNP	G	G	A	rs139748706		TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr22:50686355G>A	uc003bkg.2	-	13	1674	c.1301C>T	c.(1300-1302)GCG>GTG	p.A434V	TUBGCP6_uc003bkb.1_5'Flank|TUBGCP6_uc010har.1_5'Flank|TUBGCP6_uc010has.1_5'Flank|TUBGCP6_uc010hau.1_5'Flank|HDAC10_uc003bke.2_Missense_Mutation_p.A160V|HDAC10_uc003bkf.2_Missense_Mutation_p.A160V|HDAC10_uc010hav.2_Missense_Mutation_p.A414V|HDAC10_uc003bkh.2_Missense_Mutation_p.A227V|HDAC10_uc003bki.2_Missense_Mutation_p.A384V|HDAC10_uc003bkj.2_RNA|HDAC10_uc003bkk.1_Missense_Mutation_p.A68V	NM_032019	NP_114408	Q969S8	HDA10_HUMAN	histone deacetylase 10 isoform 1	434					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|nucleus	histone deacetylase activity|histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CAGGGCTGACGCTTCCTGTTG	0.652		NaN											0	0	0	0.006122	0	17	32									
CLASP2	23122	broad.mit.edu	37	3	33552094	33552094	+	Missense_Mutation	SNP	T	T	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr3:33552094T>A	uc003cfu.2	-	36	4627	c.4273A>T	c.(4273-4275)ACC>TCC	p.T1425S	CLASP2_uc003cfs.2_Missense_Mutation_p.T632S|CLASP2_uc003cft.2_RNA|CLASP2_uc010hgb.2_RNA	NM_015097	NP_055912	B2RTR1	B2RTR1_HUMAN	CLIP-associating protein 2	1434										ovary(3)|central_nervous_system(1)	4						AGGTTTAGGGTTTCCTTGGAC	0.398		NaN											0	0	0	0.001855	0	8	72									
WDR48	57599	broad.mit.edu	37	3	39093559	39093559	+	Missense_Mutation	SNP	G	G	T	rs147741658		TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr3:39093559G>T	uc003cit.2	+	1	53	c.43G>T	c.(43-45)GTG>TTG	p.V15L	WDR48_uc011ayt.1_Missense_Mutation_p.V15L|WDR48_uc011ayu.1_5'UTR|WDR48_uc011ayv.1_Missense_Mutation_p.V15L|WDR48_uc003ciu.2_RNA	NM_020839	NP_065890	Q8TAF3	WDR48_HUMAN	WD repeat domain 48	15					interspecies interaction between organisms|protein deubiquitination	lysosome|nucleus	protein binding			ovary(1)|breast(1)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0588)|Kidney(284;0.0738)		GCGGAGGAAAGTGCAGGTATG	0.662		NaN											1	0	6.50621e-10	0.002836	6.66555e-10	27	60									
LZTFL1	54585	broad.mit.edu	37	3	45879482	45879482	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr3:45879482C>T	uc003cox.1	-	2	203	c.65G>A	c.(64-66)CGT>CAT	p.R22H	LZTFL1_uc003coy.1_Missense_Mutation_p.R5H|LZTFL1_uc011bak.1_Intron	NM_020347	NP_065080	Q9NQ48	LZTL1_HUMAN	leucine zipper transcription factor-like 1	22											0				BRCA - Breast invasive adenocarcinoma(193;0.00867)|KIRC - Kidney renal clear cell carcinoma(197;0.0177)|Kidney(197;0.0208)		TCTCTTTGAACGAGCAAAACG	0.393		NaN											0	0	0	0.00308	0	6	65									
CADPS	8618	broad.mit.edu	37	3	62739220	62739220	+	Missense_Mutation	SNP	C	C	T	rs150415917	byFrequency	TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr3:62739220C>T	uc003dll.2	-	3	1144	c.784G>A	c.(784-786)GCA>ACA	p.A262T	CADPS_uc003dlm.2_Missense_Mutation_p.A262T|CADPS_uc003dln.2_Missense_Mutation_p.A262T	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	262					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		TCGGAGGCTGCGCTGGCTGTC	0.537		NaN											0	0	0	0.00361	0	60	63									
TMF1	7110	broad.mit.edu	37	3	69097297	69097297	+	Missense_Mutation	SNP	T	T	C	rs76863529	by1000genomes	TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr3:69097297T>C	uc003dnn.2	-	2	806	c.559A>G	c.(559-561)ATG>GTG	p.M187V	TMF1_uc011bfx.1_Missense_Mutation_p.M187V	NM_007114	NP_009045	P82094	TMF1_HUMAN	TATA element modulatory factor 1	187					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi membrane|nucleus	DNA binding|protein binding|transcription cofactor activity				0		Lung NSC(201;0.0193)|Prostate(884;0.174)		BRCA - Breast invasive adenocarcinoma(55;4.48e-05)|Epithelial(33;0.000274)|LUSC - Lung squamous cell carcinoma(21;0.0123)|KIRC - Kidney renal clear cell carcinoma(39;0.211)|Kidney(39;0.247)		GGCACCTTCATATCCGATTCT	0.393		NaN											0	0	0	0.00361	0	42	144									
ARHGAP31	57514	broad.mit.edu	37	3	119134219	119134219	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr3:119134219C>G	uc003ecj.3	+	12	3975	c.3443C>G	c.(3442-3444)TCT>TGT	p.S1148C		NM_020754	NP_065805	Q2M1Z3	RHG31_HUMAN	Cdc42 GTPase-activating protein	1148					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|focal adhesion|lamellipodium	GTPase activator activity			ovary(2)	2						ATGACCTCATCTTACTGTAAA	0.532		NaN											0	0	0	0.00632	0	27	46									
PIK3R4	30849	broad.mit.edu	37	3	130449257	130449257	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr3:130449257G>C	uc003enj.2	-	5	2061	c.1480C>G	c.(1480-1482)CTG>GTG	p.L494V		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	494	HEAT 2.				fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12						AGGAATCTCAGAGCTGTTTCT	0.299		NaN											0	0	0	0.00623	0	34	51									
TOPBP1	11073	broad.mit.edu	37	3	133362908	133362908	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr3:133362908C>T	uc003eps.2	-	11	1936	c.1804G>A	c.(1804-1806)GAA>AAA	p.E602K		NM_007027	NP_008958	Q92547	TOPB1_HUMAN	topoisomerase (DNA) II binding protein 1	602	BRCT 4.				DNA repair|response to ionizing radiation	microtubule organizing center|PML body|spindle pole	DNA binding|protein C-terminus binding			ovary(2)|kidney(2)|skin(1)|lung(1)|pancreas(1)	7						GCTTCCACTTCACACCCCAGC	0.423		NaN						Other_conserved_DNA_damage_response_genes					0	0	0	0.00361	0	54	102									
CHST2	9435	broad.mit.edu	37	3	142840195	142840195	+	Silent	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr3:142840195C>T	uc003evm.2	+	2	1426	c.537C>T	c.(535-537)TTC>TTT	p.F179F		NM_004267	NP_004258	Q9Y4C5	CHST2_HUMAN	carbohydrate (N-acetylglucosamine-6-O)	179	PAPS (Probable).|Lumenal (Potential).				inflammatory response|multicellular organismal development|N-acetylglucosamine metabolic process|sulfur compound metabolic process	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			ovary(3)	3						GCTCGTCGTTCTTCGGCGAGC	0.617		NaN											0	0	0	0.004656	0	26	29									
OTOL1	131149	broad.mit.edu	37	3	161221324	161221324	+	Nonsense_Mutation	SNP	C	C	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr3:161221324C>A	uc011bpb.1	+	4	1028	c.1028C>A	c.(1027-1029)TCG>TAG	p.S343*		NM_001080440	NP_001073909	A6NHN0	OTOL1_HUMAN	otolin-1 precursor	343	C1q.					collagen					0						GTGCCCCGGTCGGCTTTCAGC	0.517		NaN											1	0	5.35356e-11	0.00278	5.55266e-11	18	31									
SOX2	6657	broad.mit.edu	37	3	181430953	181430953	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr3:181430953G>T	uc003fkx.2	+	1	1232	c.805G>T	c.(805-807)GAC>TAC	p.D269Y	SOX2OT_uc003fkv.2_Intron|SOX2OT_uc003fkw.3_Intron	NM_003106	NP_003097	P48431	SOX2_HUMAN	sex-determining region Y-box 2	269					cell cycle arrest|chromatin organization|eye development|glial cell fate commitment|inner ear development|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of epithelial cell proliferation|negative regulation of neuron differentiation|osteoblast differentiation|pituitary gland development|positive regulation of MAPKKK cascade|positive regulation of transcription from RNA polymerase II promoter|regulation of caspase activity|response to growth factor stimulus|response to wounding|somatic stem cell maintenance	cytosol|transcription factor complex	miRNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0	all_cancers(143;1.22e-16)|Ovarian(172;0.0283)		all cancers(12;1.82e-48)|Epithelial(37;9.85e-40)|OV - Ovarian serous cystadenocarcinoma(80;7.37e-23)|Lung(8;2.01e-21)|GBM - Glioblastoma multiforme(1;2.13e-08)			CCAGGCCGGGGACCTCCGGGA	0.682		NaN	A		NSCLC|oesophageal squamous carcinoma		MICROPHTHALMIA AND ESOPHAGEAL ATRESIA SYNDROME						1	0	1.95512e-22	0.00361	2.09716e-22	47	84									
TBC1D19	55296	broad.mit.edu	37	4	26675453	26675453	+	Silent	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr4:26675453C>T	uc003gsf.3	+	11	1029	c.759C>T	c.(757-759)CCC>CCT	p.P253P	TBC1D19_uc010iew.2_Silent_p.P253P|TBC1D19_uc011bxu.1_Silent_p.P188P	NM_018317	NP_060787	Q8N5T2	TBC19_HUMAN	TBC1 domain family, member 19	253	Rab-GAP TBC.					intracellular	Rab GTPase activator activity			breast(1)	1		Breast(46;0.0503)				AAGGAAGTCCCACGGCACTGA	0.408		NaN											0	0	0	0.001984	0	5	43									
PDGFRA	5156	broad.mit.edu	37	4	55139760	55139760	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr4:55139760C>T	uc003han.3	+	10	1752	c.1421C>T	c.(1420-1422)ACG>ATG	p.T474M	PDGFRA_uc003haa.2_Intron|PDGFRA_uc010igq.1_Missense_Mutation_p.T368M|PDGFRA_uc003ham.2_RNA	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	474	Ig-like C2-type 5.|Extracellular (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	AACATCATCACGGAGATCCAC	0.493		NaN	Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			0	0	0	0.00361	0	47	58									
C4orf14	84273	broad.mit.edu	37	4	57840060	57840060	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr4:57840060G>C	uc003hck.2	-	2	1348	c.1273C>G	c.(1273-1275)CAG>GAG	p.Q425E		NM_032313	NP_115689	Q8NC60	CD014_HUMAN	hypothetical protein LOC84273	425							GTP binding			ovary(1)|breast(1)	2	Glioma(25;0.08)|all_neural(26;0.181)					ACATTAAGCTGATTTTGTTCT	0.368		NaN											0	0	0	0.003271	0	30	121									
SCARB2	950	broad.mit.edu	37	4	77102129	77102129	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr4:77102129C>G	uc003hju.1	-	3	740	c.401G>C	c.(400-402)AGA>ACA	p.R134T	SCARB2_uc011cbu.1_Intron	NM_005506	NP_005497	Q14108	SCRB2_HUMAN	scavenger receptor class B, member 2	134	Lumenal (Potential).				cell adhesion|protein targeting to lysosome	integral to plasma membrane|lysosomal lumen|lysosomal membrane|membrane fraction	enzyme binding|receptor activity				0			Lung(101;0.196)			ATTTAATGTTCTAATTAAGTC	0.318		NaN											0	0	0	0.011902	0	38	18									
DKK2	27123	broad.mit.edu	37	4	107956668	107956668	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr4:107956668C>G	uc003hyi.2	-	1	786	c.81G>C	c.(79-81)CAG>CAC	p.Q27H	DKK2_uc010ilw.1_Intron|DKK2_uc003hyj.1_Missense_Mutation_p.Q27H	NM_014421	NP_055236	Q9UBU2	DKK2_HUMAN	dickkopf homolog 2 precursor	27					multicellular organismal development|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	extracellular space				ovary(3)|lung(1)|skin(1)	5		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;6.34e-06)		AACTGCCGATCTGTGAGCTCT	0.647		NaN											0	0	0	0.009096	0	4	166									
SMAD1	4086	broad.mit.edu	37	4	146463782	146463782	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr4:146463782A>G	uc003ikc.2	+	4	1123	c.707A>G	c.(706-708)CAG>CGG	p.Q236R	SMAD1_uc003ikd.2_Missense_Mutation_p.Q236R|SMAD1_uc010iov.2_Missense_Mutation_p.Q236R|SMAD1_uc011cic.1_Intron	NM_005900	NP_005891	Q15797	SMAD1_HUMAN	Sma- and Mad-related protein 1	236					BMP signaling pathway|embryonic pattern specification|primary miRNA processing|SMAD protein complex assembly|transforming growth factor beta receptor signaling pathway	cytosol|integral to membrane|nuclear inner membrane	co-SMAD binding|I-SMAD binding|identical protein binding|protein kinase binding|sequence-specific DNA binding transcription factor activity|transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity			ovary(1)	1	all_hematologic(180;0.151)					CCCATGACCCAGGATGGCTCT	0.468		NaN											0	0	0	0.010504	0	19	384									
TLL1	7092	broad.mit.edu	37	4	166935664	166935664	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr4:166935664C>G	uc003irh.1	+	8	1641	c.994C>G	c.(994-996)CTA>GTA	p.L332V	TLL1_uc011cjn.1_Missense_Mutation_p.L332V|TLL1_uc011cjo.1_Missense_Mutation_p.L156V	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	332	Metalloprotease (By similarity).				cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		GCGAACCCGTCTAAGCAAAGG	0.463		NaN											0	0	0	0.000602	0	4	184									
TLR3	7098	broad.mit.edu	37	4	187004826	187004826	+	Silent	SNP	C	C	T	rs149490656		TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr4:187004826C>T	uc003iyq.2	+	4	2087	c.1986C>T	c.(1984-1986)AAC>AAT	p.N662N	TLR3_uc011ckz.1_Silent_p.N385N|TLR3_uc003iyr.2_Silent_p.N385N	NM_003265	NP_003256	O15455	TLR3_HUMAN	toll-like receptor 3 precursor	662	Lumenal (Potential).|LRRCT.				activation of NF-kappaB-inducing kinase activity|cellular response to mechanical stimulus|defense response to bacterium|defense response to virus|detection of virus|hyperosmotic response|I-kappaB phosphorylation|inflammatory response|innate immune response|MyD88-independent toll-like receptor signaling pathway|negative regulation of osteoclast differentiation|positive regulation of chemokine production|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|toll-like receptor 3 signaling pathway	endoplasmic reticulum membrane|endosome membrane|integral to plasma membrane	double-stranded RNA binding|transmembrane receptor activity			ovary(2)|prostate(1)|lung(1)|breast(1)	5		all_cancers(14;4.27e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.0066)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(30;1.14e-05)|GBM - Glioblastoma multiforme(59;0.000107)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.16)		ATTGGATTAACGAGACCCATA	0.443		NaN											0	0	0	0.00361	0	89	65									
KIAA0947	23379	broad.mit.edu	37	5	5476116	5476116	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:5476116G>C	uc003jdm.3	+	17	6666	c.6444G>C	c.(6442-6444)TGG>TGC	p.W2148C		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	2148										ovary(1)|central_nervous_system(1)	2						TGGATAAATGGATAAAATACA	0.313		NaN											0	0	0	0.009096	0	3	38									
ADCY2	108	broad.mit.edu	37	5	7773125	7773125	+	Silent	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:7773125C>T	uc003jdz.1	+	18	2362	c.2295C>T	c.(2293-2295)ATC>ATT	p.I765I	ADCY2_uc011cmo.1_Silent_p.I585I	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	765	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			ovary(5)|pancreas(1)|skin(1)	7						AGATGTTGATCATGATGGTGG	0.527		NaN											0	0	0	0.00361	0	47	199									
ITGA2	3673	broad.mit.edu	37	5	52351969	52351969	+	Silent	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:52351969C>T	uc003joy.2	+	9	1229	c.1086C>T	c.(1084-1086)TTC>TTT	p.F362F	ITGA2_uc011cqa.1_RNA|ITGA2_uc011cqb.1_RNA|ITGA2_uc011cqc.1_Silent_p.F286F|ITGA2_uc011cqd.1_RNA|ITGA2_uc011cqe.1_RNA	NM_002203	NP_002194	P17301	ITA2_HUMAN	integrin alpha 2 precursor	362	Extracellular (Potential).|VWFA.				axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			lung(1)	1		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				AACAAATTTTCAGCATTGAAG	0.299		NaN											0	0	0	0.010504	0	19	54									
RAB3C	115827	broad.mit.edu	37	5	58021940	58021940	+	Nonsense_Mutation	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:58021940C>T	uc003jrp.2	+	3	461	c.364C>T	c.(364-366)CAA>TAA	p.Q122*		NM_138453	NP_612462	Q96E17	RAB3C_HUMAN	RAB3C, member RAS oncogene family	122					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			ovary(1)|central_nervous_system(1)	2		all_cancers(5;9.93e-10)|all_epithelial(5;1.49e-10)|all_lung(5;8.97e-05)|Lung NSC(5;0.000139)|Prostate(74;0.0664)		OV - Ovarian serous cystadenocarcinoma(10;1.8e-34)		CAATGCAGTACAAGATTGGTA	0.398		NaN											0	0	0	0.005443	0	26	48									
CDK7	1022	broad.mit.edu	37	5	68531243	68531243	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:68531243G>C	uc003jvs.3	+	2	270	c.89G>C	c.(88-90)AGA>ACA	p.R30T	CDK7_uc010ixd.1_Missense_Mutation_p.R30T|CDK7_uc003jvt.3_5'UTR|CDK7_uc003jvu.3_5'UTR	NM_001799	NP_001790	P50613	CDK7_HUMAN	cyclin-dependent kinase 7	30	Protein kinase.				androgen receptor signaling pathway|cell division|cell proliferation|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mRNA capping|nucleotide-excision repair, DNA damage removal|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|regulation of cyclin-dependent protein kinase activity|S phase of mitotic cell cycle|termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase I promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	holo TFIIH complex|mitochondrion	androgen receptor binding|ATP binding|cyclin-dependent protein kinase activity|DNA-dependent ATPase activity|protein C-terminus binding|RNA polymerase II carboxy-terminal domain kinase activity|transcription coactivator activity			lung(1)	1		Lung NSC(167;7.26e-05)|Prostate(74;0.00634)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.98e-56)|Epithelial(20;3.54e-52)|all cancers(19;9.11e-48)|Lung(70;0.0185)		TACAAGGCCAGAGATAAGAAC	0.333		NaN						NER					0	0	0	0.007413	0	16	42									
CCDC125	202243	broad.mit.edu	37	5	68616096	68616096	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:68616096C>G	uc003jvv.1	-	1	315	c.272G>C	c.(271-273)AGA>ACA	p.R91T	CCDC125_uc003jvx.1_Missense_Mutation_p.R91T|CCDC125_uc003jvy.1_RNA|CCDC125_uc003jvw.2_5'UTR|CCDC125_uc003jvz.1_Missense_Mutation_p.R91T	NM_176816	NP_789786	Q86Z20	CC125_HUMAN	coiled-coil domain containing 125	91						cytoplasm					0		Lung NSC(167;7.26e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;2.2e-56)|Epithelial(20;2.31e-52)|all cancers(19;5.85e-48)|Lung(70;0.0183)		ATTGGAAATTCTGGACACTTG	0.418		NaN											0	0	0	0.00361	0	71	139									
RIOK2	55781	broad.mit.edu	37	5	96500768	96500768	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:96500768G>A	uc003kmz.2	-	9	1591	c.1481C>T	c.(1480-1482)TCA>TTA	p.S494L		NM_018343	NP_060813	Q9BVS4	RIOK2_HUMAN	RIO kinase 2 isoform 1	494	Protein kinase.						ATP binding|protein serine/threonine kinase activity			kidney(1)	1		all_cancers(142;0.000125)|all_epithelial(76;8.48e-07)|all_lung(232;0.0131)|Lung NSC(167;0.0161)|Colorectal(57;0.0676)|Ovarian(225;0.105)		COAD - Colon adenocarcinoma(37;0.0657)		AGGAATTGTTGAACAGCTTAC	0.358		NaN											0	0	0	0.010818	0	27	58									
CSNK1G3	1456	broad.mit.edu	37	5	122881389	122881389	+	Nonsense_Mutation	SNP	C	C	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:122881389C>G	uc003ktm.2	+	2	751	c.32C>G	c.(31-33)TCA>TGA	p.S11*	CSNK1G3_uc003ktl.2_Nonsense_Mutation_p.S11*|CSNK1G3_uc003ktn.2_Nonsense_Mutation_p.S11*|CSNK1G3_uc003kto.2_Nonsense_Mutation_p.S11*|CSNK1G3_uc011cwr.1_Intron|CSNK1G3_uc011cws.1_Intron|CSNK1G3_uc010jda.2_Nonsense_Mutation_p.S11*	NM_004384	NP_004375	Q9Y6M4	KC1G3_HUMAN	casein kinase 1, gamma 3 isoform 1	11					Wnt receptor signaling pathway	cytoplasm	ATP binding|protein serine/threonine kinase activity				0		all_cancers(142;0.0156)|Prostate(80;0.0322)|Lung NSC(810;0.245)	KIRC - Kidney renal clear cell carcinoma(527;0.165)|Kidney(363;0.229)	OV - Ovarian serous cystadenocarcinoma(64;0.000121)|Epithelial(69;0.000227)|all cancers(49;0.00176)		AAGGACAAATCAGATGATAGA	0.408		NaN											0	0	0	0.001368	0	11	33									
CHSY3	337876	broad.mit.edu	37	5	129520128	129520128	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:129520128G>A	uc003kvd.2	+	3	1293	c.1293G>A	c.(1291-1293)ATG>ATA	p.M431I		NM_175856	NP_787052	Q70JA7	CHSS3_HUMAN	chondroitin sulfate synthase 3	431	Lumenal (Potential).					Golgi cisterna membrane|integral to membrane	glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding|N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity			ovary(2)|pancreas(1)	3		all_cancers(142;0.0227)|Breast(839;0.198)|Prostate(80;0.215)|Lung NSC(810;0.239)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	OV - Ovarian serous cystadenocarcinoma(64;0.136)		GTGCCCTGATGAGCAAGCTCA	0.502		NaN											0	0	0	0.010729	0	9	86									
KLHL3	26249	broad.mit.edu	37	5	136969816	136969816	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:136969816G>A	uc010jek.2	-	12	1804	c.1360C>T	c.(1360-1362)CGC>TGC	p.R454C	KLHL3_uc011cyc.1_Missense_Mutation_p.R189C|KLHL3_uc003lbr.3_Missense_Mutation_p.R372C|KLHL3_uc011cyd.1_Intron|KLHL3_uc010jel.1_Missense_Mutation_p.R189C	NM_017415	NP_059111	Q9UH77	KLHL3_HUMAN	kelch-like 3	454	Kelch 4.					cytoplasm|cytoskeleton	actin binding|structural molecule activity				0		all_hematologic(541;3.67e-07)|Breast(839;7.61e-05)|Prostate(281;0.000825)|Ovarian(839;0.0481)|all_lung(232;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)	GBM - Glioblastoma multiforme(465;0.0223)		AGACACTGGCGGGAAGCTCCA	0.557		NaN											0	0	0	0.004672	0	3	92									
WNT8A	7478	broad.mit.edu	37	5	137426224	137426224	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:137426224G>A	uc003lcd.1	+	6	523	c.518G>A	c.(517-519)AGA>AAA	p.R173K	BRD8_uc003lcc.1_Intron|WNT8A_uc011cyj.1_Missense_Mutation_p.R191K|WNT8A_uc011cyk.1_Missense_Mutation_p.R191K	NM_058244	NP_490645	Q9H1J5	WNT8A_HUMAN	wingless-type MMTV integration site family,	173					brain segmentation|canonical Wnt receptor signaling pathway involved in neural crest cell differentiation|cell migration involved in gastrulation|dorsal/ventral pattern formation|ectoderm development|endoderm development|eye development|hindbrain development|mesodermal cell fate commitment|negative regulation of Wnt receptor signaling pathway|neural crest cell fate commitment|neural plate pattern specification|notochord development|palate development|polarity specification of anterior/posterior axis|polarity specification of proximal/distal axis|positive regulation of fibroblast growth factor receptor signaling pathway|regulation of transcription involved in anterior/posterior axis specification|response to retinoic acid|somitogenesis|spinal cord anterior/posterior patterning|tail morphogenesis|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	frizzled binding|signal transducer activity			ovary(1)|lung(1)|breast(1)|skin(1)	4			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			AAGGCAGTGAGAGCCACCATG	0.453		NaN											0	0	0	0.004656	0	21	30									
PCDHA10	56139	broad.mit.edu	37	5	140237156	140237156	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:140237156C>T	uc003lhx.2	+	1	1523	c.1523C>T	c.(1522-1524)TCG>TTG	p.S508L	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Missense_Mutation_p.S508L|PCDHA10_uc011dad.1_Missense_Mutation_p.S508L	NM_018901	NP_061724	Q9Y5I2	PCDAA_HUMAN	protocadherin alpha 10 isoform 1 precursor	508	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)|breast(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGCTACGTGTCGGTGCACGCG	0.692		NaN											0	0	0	0.00361	0	44	116									
PCDHB9	56127	broad.mit.edu	37	5	140569145	140569145	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:140569145G>A	uc003liw.1	+	3	2254	c.2254G>A	c.(2254-2256)GAG>AAG	p.E752K	PCDHB10_uc003lix.2_5'Flank	NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	752	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTACCAGTACGAGGTGTGTCT	0.622		NaN											0	0	0	0.00361	0	71	170									
PCDHB9	56127	broad.mit.edu	37	5	140569220	140569220	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:140569220C>T	uc003liw.1	+	3	2329	c.2329C>T	c.(2329-2331)CAT>TAT	p.H777Y	PCDHB10_uc003lix.2_5'Flank	NM_019119	NP_061992	Q9Y5E1	PCDB9_HUMAN	protocadherin beta 9 precursor	777	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CCTCCCGCCCCATAGGGGTGG	0.463		NaN											0	0	0	0.00361	0	45	96									
PCDHGA10	56106	broad.mit.edu	37	5	140793096	140793096	+	Silent	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:140793096G>A	uc003lkl.1	+	1	354	c.354G>A	c.(352-354)GTG>GTA	p.V118V	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc011day.1_Silent_p.V118V	NM_018913	NP_061736	Q9Y5H3	PCDGA_HUMAN	protocadherin gamma subfamily A, 10 isoform 1	118	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAGACAGGGTGAAACTTTTTG	0.463		NaN											0	0	0	0.010504	0	19	32									
GPR151	134391	broad.mit.edu	37	5	145894805	145894805	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:145894805G>C	uc003lod.1	-	1	872	c.872C>G	c.(871-873)TCT>TGT	p.S291C		NM_194251	NP_919227	Q8TDV0	GP151_HUMAN	G protein-coupled receptor 151	291	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAAGACTTGAGACAGGGCTAT	0.502		NaN											0	0	0	0.007413	0	17	38									
ZFP2	80108	broad.mit.edu	37	5	178359437	178359437	+	Missense_Mutation	SNP	A	A	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:178359437A>T	uc003mjn.1	+	5	1632	c.1123A>T	c.(1123-1125)ATT>TTT	p.I375F	ZFP2_uc010jky.2_Missense_Mutation_p.I375F|ZFP2_uc010jkx.1_Missense_Mutation_p.I375F	NM_030613	NP_085116	Q6ZN57	ZFP2_HUMAN	zinc finger protein 2 homolog	375	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3	all_cancers(89;0.000639)|all_epithelial(37;0.000109)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.00655)|GBM - Glioblastoma multiforme(465;0.0302)|OV - Ovarian serous cystadenocarcinoma(192;0.0615)|Epithelial(171;0.111)		GCATCAGGTCATTCACACTGG	0.423		NaN											0	0	0	0.010729	0	9	82									
MAML1	9794	broad.mit.edu	37	5	179201773	179201773	+	Silent	SNP	G	G	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr5:179201773G>T	uc003mkm.2	+	5	3209	c.2946G>T	c.(2944-2946)GGG>GGT	p.G982G	MAML1_uc003mkn.1_Intron	NM_014757	NP_055572	Q92585	MAML1_HUMAN	mastermind-like 1	982					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	peptide antigen binding|protein kinase binding|transcription coactivator activity			lung(4)|ovary(2)	6	all_cancers(89;0.000197)|all_epithelial(37;6.7e-05)|Renal(175;0.000159)|Lung NSC(126;0.00121)|all_lung(126;0.00218)	all_cancers(40;0.0308)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			GTGGCAGTGGGCTCTCTAGTG	0.627		NaN											1	0	1.37657e-19	0.012319	1.46406e-19	22	52									
BTN2A2	10385	broad.mit.edu	37	6	26393028	26393028	+	Missense_Mutation	SNP	T	T	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr6:26393028T>C	uc003nhq.2	+	8	1491	c.1405T>C	c.(1405-1407)TAC>CAC	p.Y469H	BTN2A2_uc011dkg.1_3'UTR|BTN2A2_uc003nhr.2_Missense_Mutation_p.Y353H|BTN2A2_uc011dkh.1_Missense_Mutation_p.Y259H|BTN2A2_uc003nhs.2_Intron|BTN2A2_uc003nht.2_Missense_Mutation_p.Y469H|BTN2A2_uc011dki.1_3'UTR	NM_006995	NP_008926	Q8WVV5	BT2A2_HUMAN	butyrophilin, subfamily 2, member A2 isoform a	469	B30.2/SPRY.|Cytoplasmic (Potential).				negative regulation of activated T cell proliferation|negative regulation of cellular metabolic process|negative regulation of cytokine secretion	integral to membrane					0						ATCGCACATCTACACATGTCC	0.542		NaN											0	0	0	0.001368	0	10	80									
TNXB	7148	broad.mit.edu	37	6	31977552	31977552	+	Silent	SNP	C	C	G	rs77471377		TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr6:31977552C>G	uc011dpc.1	-	12	2352	c.1443G>C	c.(1441-1443)CGG>CGC	p.R481R		NM_032470	NP_115859	P22105	TENX_HUMAN	tenascin XB isoform 2	4097	Fibrinogen C-terminal.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						GGGGCCGCTCCCGGTTGCCGT	0.667		NaN											0	0	0	0.001168	0	3	31									
CUL7	9820	broad.mit.edu	37	6	43011253	43011253	+	Silent	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr6:43011253G>A	uc003otq.2	-	17	3591	c.3288C>T	c.(3286-3288)CTC>CTT	p.L1096L	CUL7_uc010jyg.2_Silent_p.L375L|CUL7_uc011dvb.1_Silent_p.L1180L|CUL7_uc010jyh.2_Silent_p.L89L|KLC4_uc003otr.1_Intron	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	1096					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			GCAGGTGAGTGAGACGGCGCA	0.647		NaN											0	0	0	0.00361	0	79	12									
RIMS1	22999	broad.mit.edu	37	6	73110200	73110200	+	Silent	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr6:73110200G>C	uc003pga.2	+	34	4940	c.4863G>C	c.(4861-4863)GTG>GTC	p.V1621V	RIMS1_uc011dyb.1_Silent_p.V1018V|RIMS1_uc003pgc.2_Silent_p.V1036V|RIMS1_uc010kaq.2_Silent_p.V941V|RIMS1_uc011dyc.1_Silent_p.V746V|RIMS1_uc010kar.2_Silent_p.V689V|RIMS1_uc011dyd.1_Silent_p.V755V|RIMS1_uc003pgf.2_Silent_p.V621V|RIMS1_uc003pgg.2_Silent_p.V517V|RIMS1_uc003pgi.2_Silent_p.V437V|RIMS1_uc003pgh.2_Silent_p.V488V|RIMS1_uc003pgd.2_Silent_p.V687V|RIMS1_uc003pge.2_Silent_p.V661V|RIMS1_uc011dye.1_Silent_p.V427V|RIMS1_uc011dyf.1_Silent_p.V245V|RIMS1_uc011dyg.1_Silent_p.V148V	NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	1621	C2 2.				calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				CTCTGCAGGTGATTGTCTGGG	0.478		NaN											0	0	0	0.010729	0	11	43									
DOPEY1	23033	broad.mit.edu	37	6	83818645	83818645	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr6:83818645C>G	uc003pjs.1	+	5	597	c.337C>G	c.(337-339)CTT>GTT	p.L113V	DOPEY1_uc011dyy.1_Missense_Mutation_p.L113V|DOPEY1_uc010kbl.1_Missense_Mutation_p.L113V	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	113					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		ATTATTTCCTCTTCTTGCAAA	0.313		NaN											0	0	0	0.007291	0	24	56									
KLHL32	114792	broad.mit.edu	37	6	97561859	97561859	+	Silent	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr6:97561859C>T	uc010kcm.1	+	7	1300	c.828C>T	c.(826-828)GTC>GTT	p.V276V	KLHL32_uc003poy.2_Silent_p.V276V|KLHL32_uc011ead.1_Silent_p.V240V|KLHL32_uc003poz.2_Intron|KLHL32_uc011eae.1_Silent_p.V207V|KLHL32_uc003ppa.2_Intron	NM_052904	NP_443136	Q96NJ5	KLH32_HUMAN	kelch-like 32	276										ovary(3)|skin(1)	4		all_cancers(76;1.19e-06)|Acute lymphoblastic leukemia(125;5.83e-10)|all_hematologic(75;3.67e-07)|all_epithelial(107;0.00778)|Colorectal(196;0.122)		BRCA - Breast invasive adenocarcinoma(108;0.0558)		CACAGCCTGTCTGGCAGACTC	0.542		NaN											0	0	0	0.004878	0	31	43									
FIG4	9896	broad.mit.edu	37	6	110110816	110110816	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr6:110110816G>A	uc003ptt.2	+	19	2331	c.2116G>A	c.(2116-2118)GTT>ATT	p.V706I	FIG4_uc011eau.1_Missense_Mutation_p.V429I	NM_014845	NP_055660	Q92562	FIG4_HUMAN	Sac domain-containing inositol phosphatase 3	706					cell death	endosome membrane	protein binding			ovary(1)	1		all_cancers(87;8.63e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000124)|all_lung(197;0.0187)|Colorectal(196;0.0492)|Lung SC(18;0.0548)		OV - Ovarian serous cystadenocarcinoma(136;0.0355)|Epithelial(106;0.038)|all cancers(137;0.0425)|BRCA - Breast invasive adenocarcinoma(108;0.079)		GCCTAAGACCGTTGGAATTGA	0.358		NaN											0	0	0	0.007291	0	22	63									
SYNE1	23345	broad.mit.edu	37	6	152772267	152772267	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr6:152772267G>A	uc010kiw.2	-	26	3703	c.3101C>T	c.(3100-3102)TCT>TTT	p.S1034F	SYNE1_uc003qot.3_Missense_Mutation_p.S1041F|SYNE1_uc003qou.3_Missense_Mutation_p.S1034F|SYNE1_uc010kjb.1_Missense_Mutation_p.S1017F|SYNE1_uc003qow.2_Missense_Mutation_p.S329F|SYNE1_uc003qox.1_Missense_Mutation_p.S550F	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	1034	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TTCTTCTACAGAGGCTAAGAA	0.443		NaN								HNSCC(10;0.0054)			0	0	0	0.00623	0	37	70									
EZR	7430	broad.mit.edu	37	6	159192335	159192335	+	Missense_Mutation	SNP	G	G	C	rs139648265	byFrequency	TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr6:159192335G>C	uc003qrt.3	-	8	1115	c.900C>G	c.(898-900)ATC>ATG	p.I300M	EZR_uc011efr.1_5'Flank|EZR_uc011efs.1_Missense_Mutation_p.I268M|EZR_uc003qru.3_Missense_Mutation_p.I300M	NM_003379	NP_003370	P15311	EZRI_HUMAN	ezrin	300	Interaction with SCYL3.				actin filament bundle assembly|axon guidance|cytoskeletal anchoring at plasma membrane|leukocyte cell-cell adhesion|membrane to membrane docking|regulation of cell shape	actin filament|apical plasma membrane|basolateral plasma membrane|cortical cytoskeleton|cytosol|extrinsic to membrane|filopodium|microvillus membrane|nucleolus|ruffle membrane	actin filament binding|cell adhesion molecule binding			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-17)|BRCA - Breast invasive adenocarcinoma(81;6.58e-06)		GCTGCACCTCGATGGTGTCAG	0.597		NaN											0	0	0	0.007413	0	17	46									
PNLDC1	154197	broad.mit.edu	37	6	160239602	160239602	+	Silent	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr6:160239602C>T	uc003qsx.1	+	16	1311	c.1140C>T	c.(1138-1140)CCC>CCT	p.P380P	PNLDC1_uc003qsy.1_Silent_p.P391P	NM_173516	NP_775787	Q8NA58	PNDC1_HUMAN	poly(A)-specific ribonuclease (PARN)-like domain	380	Cytoplasmic (Potential).					integral to membrane|nucleus	nucleic acid binding				0		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;1.55e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		ACCCCGTGCCCGAGTCATCCT	0.552		NaN											0	0	0	0.012319	0	18	37									
DLL1	28514	broad.mit.edu	37	6	170597419	170597419	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr6:170597419C>T	uc003qxm.2	-	4	1048	c.578G>A	c.(577-579)CGT>CAT	p.R193H	DLL1_uc011ehc.1_Missense_Mutation_p.R193H	NM_005618	NP_005609	O00548	DLL1_HUMAN	delta-like 1 precursor	193	Extracellular (Potential).|DSL.				cell communication|cell fate determination|hemopoiesis|Notch receptor processing|Notch signaling pathway|regulation of cell adhesion	extracellular region|integral to plasma membrane	calcium ion binding|Notch binding			lung(4)|ovary(1)	5		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;6.71e-23)|BRCA - Breast invasive adenocarcinoma(81;4.81e-06)|GBM - Glioblastoma multiforme(31;0.0584)		GTCCCGGGGACGGCAGAAAAC	0.622		NaN											0	0	0	0.012213	0	24	49									
MICALL2	79778	broad.mit.edu	37	7	1487240	1487240	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:1487240C>T	uc003skj.3	-	4	643	c.496G>A	c.(496-498)GAG>AAG	p.E166K		NM_182924	NP_891554	Q8IY33	MILK2_HUMAN	MICAL-like 2 isoform 1	166						cytoplasm|cytoskeleton	zinc ion binding			central_nervous_system(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)		CCTGCACCCTCATTCCTCCTC	0.677		NaN											0	0	0	0.006214	0	6	16									
MICALL2	79778	broad.mit.edu	37	7	1487250	1487250	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:1487250C>G	uc003skj.3	-	4	633	c.486G>C	c.(484-486)CAG>CAC	p.Q162H		NM_182924	NP_891554	Q8IY33	MILK2_HUMAN	MICAL-like 2 isoform 1	162						cytoplasm|cytoskeleton	zinc ion binding			central_nervous_system(1)	1		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0178)|OV - Ovarian serous cystadenocarcinoma(56;6.01e-15)		CATTCCTCCTCTGGACCACAG	0.672		NaN											0	0	0	0.006214	0	6	15									
DFNA5	1687	broad.mit.edu	37	7	24745981	24745981	+	Silent	SNP	G	G	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:24745981G>T	uc010kus.1	-	8	1093	c.1005C>A	c.(1003-1005)GTC>GTA	p.V335V	DFNA5_uc003swz.2_Silent_p.V171V|DFNA5_uc003sxa.1_Silent_p.V335V|DFNA5_uc010kut.1_Silent_p.V171V	NM_001127453	NP_001120925	O60443	DFNA5_HUMAN	deafness, autosomal dominant 5 protein isoform	335					sensory perception of sound					ovary(1)	1						AGAGGCCGCTGACCAGGTCAT	0.647		NaN											1	0	6.32553e-13	0.004656	6.588e-13	21	14									
NFE2L3	9603	broad.mit.edu	37	7	26224981	26224981	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:26224981G>A	uc003sxq.2	+	4	1935	c.1663G>A	c.(1663-1665)GTC>ATC	p.V555I		NM_004289	NP_004280	Q9Y4A8	NF2L3_HUMAN	nuclear factor erythroid 2-like 3	555					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			skin(3)|ovary(1)	4						AGATGAAATTGTCGGCATGCC	0.398		NaN											0	0	0	0.001855	0	11	81									
LOC402644	402644	broad.mit.edu	37	7	28319234	28319234	+	Missense_Mutation	SNP	A	A	C	rs177484	by1000genomes	TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:28319234A>C	uc010kuz.1	-	1	85	c.85T>G	c.(85-87)TTT>GTT	p.F29V		NM_001126493	NP_001119965			hypothetical protein LOC402644												0						GTCTTTGGAAACTTTTCTGCA	0.468		NaN											0	0	0	0.009096	0	3	62									
AMPH	273	broad.mit.edu	37	7	38543250	38543250	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:38543250C>T	uc003tgu.2	-	3	274	c.205G>A	c.(205-207)GGC>AGC	p.G69S	AMPH_uc003tgv.2_Missense_Mutation_p.G69S	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	69	BAR.|Potential.				endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						TACACATTACCTTTGATTGCT	0.393		NaN											0	0	0	0.00361	0	129	87									
IKZF1	10320	broad.mit.edu	37	7	50468280	50468280	+	Silent	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:50468280C>T	uc003tow.3	+	9	1683	c.1515C>T	c.(1513-1515)TTC>TTT	p.F505F	IKZF1_uc003tox.3_Silent_p.F463F|IKZF1_uc003toy.3_Silent_p.F463F|IKZF1_uc011kck.1_Silent_p.F418F|IKZF1_uc003toz.3_Silent_p.F475F|IKZF1_uc010kyx.2_Silent_p.F245F|IKZF1_uc003tpa.3_Silent_p.F247F	NM_006060	NP_006051	Q13422	IKZF1_HUMAN	zinc finger protein, subfamily 1A, 1 (Ikaros)	505	C2H2-type 6.				cell cycle|chromatin modification|mesoderm development	cytoplasm|nucleus	zinc ion binding			haematopoietic_and_lymphoid_tissue(147)|lung(1)	148	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;7.29e-10)|all_hematologic(4;4.8e-07)				GGTACGAGTTCTCGTCGCACA	0.607		NaN	D		ALL								0	0	0	0.009535	0	24	46									
GRB10	2887	broad.mit.edu	37	7	50660679	50660679	+	Silent	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:50660679G>C	uc003tpi.2	-	16	1786	c.1755C>G	c.(1753-1755)CTC>CTG	p.L585L	GRB10_uc003tph.3_Silent_p.L527L|GRB10_uc003tpj.2_Silent_p.L539L|GRB10_uc003tpk.2_Silent_p.L585L|GRB10_uc010kzb.2_Silent_p.L527L|GRB10_uc003tpl.2_Silent_p.L579L|GRB10_uc003tpm.2_Silent_p.L527L|GRB10_uc003tpn.2_Silent_p.L527L	NM_005311	NP_005302	Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10 isoform	585					insulin receptor signaling pathway|insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|insulin receptor binding|SH3/SH2 adaptor activity			lung(3)|ovary(2)|upper_aerodigestive_tract(1)	6	Glioma(55;0.08)|all_neural(89;0.245)					AGTGGTGCTTGAGTTTGCAAG	0.522		NaN							Russell-Silver_syndrome				0	0	0	0.00361	0	88	106									
AUTS2	26053	broad.mit.edu	37	7	70255920	70255920	+	Silent	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:70255920C>T	uc003tvw.3	+	19	4461	c.3718C>T	c.(3718-3720)CTG>TTG	p.L1240L	AUTS2_uc003tvx.3_Silent_p.L1216L|AUTS2_uc011keg.1_Silent_p.L692L	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	1240										ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		GACGACTCCTCTGTCCGCAGA	0.622		NaN											0	0	0	0.001855	0	13	15									
TYW1B	441250	broad.mit.edu	37	7	72193853	72193853	+	Nonsense_Mutation	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:72193853G>A	uc011kej.1	-	12	1288	c.1129C>T	c.(1129-1131)CAG>TAG	p.Q377*	TYW1B_uc011keh.1_Nonsense_Mutation_p.Q215*|TYW1B_uc011kei.1_Nonsense_Mutation_p.Q3*|TYW1B_uc011kek.1_RNA	NM_001145440	NP_001138912	Q6NUM6	TYW1B_HUMAN	tRNA-yW synthesizing protein 1 homolog B isoform	377					tRNA processing		4 iron, 4 sulfur cluster binding|FMN binding|iron ion binding|oxidoreductase activity				0						ATTTCAGGCTGGTCCATCTTC	0.423		NaN											0	0	0	0.006122	0	13	9									
ST7	7982	broad.mit.edu	37	7	116859168	116859168	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:116859168A>G	uc003vin.2	+	14	1650	c.1436A>G	c.(1435-1437)AAG>AGG	p.K479R	ST7_uc011knl.1_Missense_Mutation_p.K456R|ST7_uc003vio.2_Missense_Mutation_p.K456R|ST7_uc003viq.2_Missense_Mutation_p.K433R|ST7_uc011knm.1_Missense_Mutation_p.K436R|ST7_uc003vir.2_Missense_Mutation_p.K399R|ST7_uc011knn.1_Missense_Mutation_p.K427R	NM_021908	NP_068708	Q9NRC1	ST7_HUMAN	suppression of tumorigenicity 7 isoform b	479						integral to membrane	binding			central_nervous_system(1)|skin(1)	2	all_cancers(3;3.88e-07)|all_epithelial(6;3.42e-07)|Lung NSC(10;0.00072)|all_lung(10;0.000847)		STAD - Stomach adenocarcinoma(10;0.000512)	LUSC - Lung squamous cell carcinoma(290;0.133)		CCCTTGGAAAAGGGGCACCTA	0.453		NaN											0	0	0	0.001168	0	3	192									
CFTR	1080	broad.mit.edu	37	7	117232685	117232685	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:117232685G>A	uc003vjd.2	+	14	2596	c.2464G>A	c.(2464-2466)GAA>AAA	p.E822K	CFTR_uc011knq.1_Missense_Mutation_p.E228K	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	822	Cytoplasmic (Potential).		E -> K (in CF).		respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	GGAAATAAGTGAAGAAATTAA	0.403		NaN							Cystic_Fibrosis				0	0	0	0.005443	0	21	63									
C7orf58	79974	broad.mit.edu	37	7	120782154	120782154	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:120782154C>A	uc003vjq.3	+	16	2461	c.2014C>A	c.(2014-2016)CTG>ATG	p.L672M	C7orf58_uc003vjs.3_Missense_Mutation_p.L672M|C7orf58_uc003vjt.3_Missense_Mutation_p.L452M	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	672						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					CCGCCCAAGTCTGCCCTTGTT	0.443		NaN											1	0	4.83814e-26	0.00361	5.2119e-26	58	135									
GPR37	2861	broad.mit.edu	37	7	124404068	124404068	+	Silent	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:124404068G>A	uc003vli.2	-	1	1614	c.963C>T	c.(961-963)CAC>CAT	p.H321H		NM_005302	NP_005293	O15354	GPR37_HUMAN	G protein-coupled receptor 37 precursor	321	Extracellular (Potential).					endoplasmic reticulum membrane|integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|lung(1)|central_nervous_system(1)	3						TGGTCAGCTCGTGGAAGATGA	0.522		NaN											0	0	0	0.004482	0	6	192									
MKRN1	23608	broad.mit.edu	37	7	140159649	140159649	+	Silent	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:140159649G>C	uc003vvt.2	-	3	627	c.402C>G	c.(400-402)CTC>CTG	p.L134L	MKRN1_uc003vvs.2_Silent_p.L70L|MKRN1_uc011krd.1_Intron|MKRN1_uc003vvv.3_Silent_p.L134L|MKRN1_uc003vvu.3_Silent_p.L70L	NM_013446	NP_038474	Q9UHC7	MKRN1_HUMAN	makorin ring finger protein 1 isoform 1	134							ligase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.00956)					CTATCGATGAGAGACTTGAGG	0.413		NaN											0	0	0	0.004878	0	32	87									
ZNF425	155054	broad.mit.edu	37	7	148802225	148802225	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:148802225G>C	uc003wfj.2	-	4	811	c.738C>G	c.(736-738)TTC>TTG	p.F246L		NM_001001661	NP_001001661	Q6IV72	ZN425_HUMAN	zinc finger protein 425	246	C2H2-type 2.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CACTGCACTGGAACCGCTTCT	0.582		NaN											0	0	0	0.00632	0	24	57									
ZNF467	168544	broad.mit.edu	37	7	149463272	149463272	+	Missense_Mutation	SNP	C	C	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr7:149463272C>G	uc003wgd.2	-	5	460	c.319G>C	c.(319-321)GAG>CAG	p.E107Q	ZNF467_uc003wgc.2_Intron	NM_207336	NP_997219	Q7Z7K2	ZN467_HUMAN	zinc finger protein 467	107					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			TCGACCTCCTCTTCTGCCTCC	0.572		NaN											0	0	0	0.007835	0	34	44									
USP17L2	377630	broad.mit.edu	37	8	11995859	11995859	+	Silent	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr8:11995859G>A	uc003wvc.1	-	1	411	c.411C>T	c.(409-411)CAC>CAT	p.H137H	FAM66D_uc011kxp.1_Intron|FAM66D_uc011kxo.1_Intron	NM_201402	NP_958804	Q6R6M4	U17L2_HUMAN	deubiquitinating enzyme 3	137					apoptosis|cell cycle|G2/M transition checkpoint|mitotic cell cycle G1/S transition checkpoint|protein deubiquitination|ubiquitin-dependent protein catabolic process	nucleus	ubiquitin thiolesterase activity|ubiquitin-specific protease activity			skin(2)|upper_aerodigestive_tract(1)	3						GACCAGGACTGTGGAGGGCCC	0.532		NaN											0	0	0	0.006122	0	12	29									
ARFGEF1	10565	broad.mit.edu	37	8	68150646	68150646	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr8:68150646C>T	uc003xxo.1	-	22	3611	c.3221G>A	c.(3220-3222)CGA>CAA	p.R1074Q	ARFGEF1_uc003xxl.1_Missense_Mutation_p.R528Q|ARFGEF1_uc003xxn.1_Missense_Mutation_p.R57Q	NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	1074					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			TTCTCTGCCTCGCACTGTTCC	0.403		NaN											0	0	0	0.00361	0	41	84									
ARFGEF1	10565	broad.mit.edu	37	8	68150723	68150723	+	Silent	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr8:68150723C>T	uc003xxo.1	-	22	3534	c.3144G>A	c.(3142-3144)CTG>CTA	p.L1048L	ARFGEF1_uc003xxl.1_Silent_p.L502L|ARFGEF1_uc003xxn.1_Silent_p.L31L	NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	1048					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			TGATGCACTTCAGAATCTTAA	0.368		NaN											0	0	0	0.008871	0	20	32									
ZFHX4	79776	broad.mit.edu	37	8	77767807	77767807	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr8:77767807C>A	uc003yav.2	+	10	8902	c.8515C>A	c.(8515-8517)CAA>AAA	p.Q2839K	ZFHX4_uc003yau.1_Missense_Mutation_p.Q2884K|ZFHX4_uc003yaw.1_Missense_Mutation_p.Q2839K	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	2839						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CGACCACGACCAAAGCTTTTA	0.522		NaN								HNSCC(33;0.089)			1	0	1.90627e-21	0.012319	2.03606e-21	17	37									
PKIA	5569	broad.mit.edu	37	8	79513978	79513978	+	Missense_Mutation	SNP	A	A	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr8:79513978A>T	uc003yba.2	+	4	677	c.153A>T	c.(151-153)GAA>GAT	p.E51D	PKIA_uc003ybb.2_Missense_Mutation_p.E51D|PKIA_uc010lzo.2_Missense_Mutation_p.E51D	NM_006823	NP_006814	P61925	IPKA_HUMAN	cAMP-dependent protein kinase inhibitor alpha	51							cAMP-dependent protein kinase inhibitor activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CTTTTGCAGAAGGTGAAGAAG	0.383		NaN											0	0	0	0.002299	0	21	25									
SPAG1	6674	broad.mit.edu	37	8	101251630	101251630	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr8:101251630G>C	uc003yjh.1	+	17	2364	c.2278G>C	c.(2278-2280)GAG>CAG	p.E760Q	SPAG1_uc003yji.1_Missense_Mutation_p.E760Q	NM_172218	NP_757367	Q07617	SPAG1_HUMAN	sperm associated antigen 1	760					single fertilization	cytoplasm	GTP binding|hydrolase activity			ovary(2)|central_nervous_system(1)	3	all_cancers(14;2.35e-05)|all_epithelial(15;5.2e-08)|Lung NSC(17;0.000283)|all_lung(17;0.000823)	Breast(495;0.195)	Epithelial(11;1.12e-09)|all cancers(13;1.26e-07)|OV - Ovarian serous cystadenocarcinoma(57;4.37e-05)|STAD - Stomach adenocarcinoma(118;0.0525)	KIRC - Kidney renal clear cell carcinoma(542;0.00178)|READ - Rectum adenocarcinoma(644;0.236)		TGAGATTCAAGAGGTATTTGT	0.353		NaN											0	0	0	0.004289	0	32	53									
DPYS	1807	broad.mit.edu	37	8	105436562	105436562	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr8:105436562G>A	uc003yly.3	-	7	1277	c.1148C>T	c.(1147-1149)GCC>GTC	p.A383V		NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	383					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			AAAAATTTTGGCTGCATTTGT	0.348		NaN											0	0	0	0.006214	0	9	80									
TRPS1	7227	broad.mit.edu	37	8	116616680	116616680	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr8:116616680C>T	uc003ynz.2	-	3	1936	c.1477G>A	c.(1477-1479)GAG>AAG	p.E493K	TRPS1_uc011lhy.1_Missense_Mutation_p.E497K|TRPS1_uc003yny.2_Missense_Mutation_p.E506K|TRPS1_uc010mcy.2_Missense_Mutation_p.E493K	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	493					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			GTCATTGTCTCTCCTTCTGAA	0.463		NaN							Langer-Giedion_syndrome				0	0	0	0.006214	0	10	119									
UNC13B	10497	broad.mit.edu	37	9	35400365	35400365	+	Missense_Mutation	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr9:35400365C>T	uc003zwq.2	+	36	4454	c.4162C>T	c.(4162-4164)CGC>TGC	p.R1388C	UNC13B_uc003zwr.2_Missense_Mutation_p.R1388C	NM_006377	NP_006368	O14795	UN13B_HUMAN	UNC13 (C. elegans)-like	1388	MHD2.				excretion|induction of apoptosis|intracellular signal transduction	cell junction|Golgi apparatus|synapse	metal ion binding|receptor activity			ovary(3)|large_intestine(1)|skin(1)	5	all_epithelial(49;0.212)		LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)|STAD - Stomach adenocarcinoma(86;0.194)			GCAGTCTCTACGCTATGCCCT	0.522		NaN											0	0	0	0.00361	0	119	174									
TJP2	9414	broad.mit.edu	37	9	71844153	71844153	+	Nonsense_Mutation	SNP	G	G	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr9:71844153G>T	uc004ahe.2	+	10	1707	c.1507G>T	c.(1507-1509)GAA>TAA	p.E503*	TJP2_uc011lrs.1_Nonsense_Mutation_p.E480*|TJP2_uc011lrt.1_Nonsense_Mutation_p.E480*|TJP2_uc004ahd.2_Nonsense_Mutation_p.E503*|TJP2_uc004ahf.2_Nonsense_Mutation_p.E503*|TJP2_uc011lru.1_Nonsense_Mutation_p.E507*|TJP2_uc011lrv.1_Nonsense_Mutation_p.E525*	NM_004817	NP_004808	Q9UDY2	ZO2_HUMAN	tight junction protein 2 (zona occludens 2)	503					cellular component disassembly involved in apoptosis	adherens junction|cytoplasm|nucleus|tight junction	guanylate kinase activity|protein binding				0						TCCTGAAGATGAAGCAATATA	0.423		NaN											1	0	6.23295e-54	0.00361	6.83175e-54	102	50									
GALNT12	79695	broad.mit.edu	37	9	101570311	101570311	+	Missense_Mutation	SNP	A	A	G			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr9:101570311A>G	uc004ayz.2	+	1	331	c.331A>G	c.(331-333)ATC>GTC	p.I111V		NM_024642	NP_078918	Q8IXK2	GLT12_HUMAN	N-acetylgalactosaminyltransferase 12	111	Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			upper_aerodigestive_tract(1)|ovary(1)	2		Acute lymphoblastic leukemia(62;0.0559)				CAGCGACCGCATCTCACTGCA	0.692		NaN											0	0	0	0.001168	0	5	5									
INVS	27130	broad.mit.edu	37	9	103002414	103002414	+	Missense_Mutation	SNP	G	G	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr9:103002414G>T	uc004bap.1	+	6	900	c.688G>T	c.(688-690)GCT>TCT	p.A230S	INVS_uc010mta.1_Missense_Mutation_p.A134S|INVS_uc011lve.1_Missense_Mutation_p.A134S|INVS_uc004bao.1_Missense_Mutation_p.A230S|INVS_uc004baq.1_Missense_Mutation_p.A134S|INVS_uc004bar.1_Missense_Mutation_p.A134S|INVS_uc010mtb.1_5'UTR	NM_014425	NP_055240	Q9Y283	INVS_HUMAN	inversin isoform a	230	ANK 7.				negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|membrane|microtubule|nucleus|spindle	calmodulin binding			ovary(2)	2		Acute lymphoblastic leukemia(62;0.056)				CTTTGCAGTTGCTGATGGGAA	0.463		NaN											1	0	4.11147e-13	0.003755	4.29992e-13	32	59									
C9orf78	51759	broad.mit.edu	37	9	132590500	132590500	+	Silent	SNP	G	G	A	rs147768922	byFrequency	TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr9:132590500G>A	uc004byp.2	-	9	882	c.810C>T	c.(808-810)AAC>AAT	p.N270N	C9orf78_uc004byo.2_Missense_Mutation_p.T185M	NM_016520	NP_057604	Q9NZ63	CI078_HUMAN	chromosome 9 open reading frame 78	270											0		Ovarian(14;0.00556)				TTGCCTTCTCGTTAGCAGGAC	0.413		NaN											0	0	0	0.00361	0	57	69									
RXRA	6256	broad.mit.edu	37	9	137328351	137328351	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr9:137328351C>A	uc004cfb.2	+	10	1442	c.1280C>A	c.(1279-1281)TCC>TAC	p.S427Y	RXRA_uc004cfc.1_Missense_Mutation_p.S330Y	NM_002957	NP_002948	P19793	RXRA_HUMAN	retinoid X receptor, alpha	427	Ligand-binding.				cellular lipid metabolic process|cholesterol metabolic process|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to retinoic acid|vitamin metabolic process	nuclear chromatin|nucleoplasm	enzyme binding|ligand-regulated transcription factor activity|protein heterodimerization activity|retinoic acid-responsive element binding|retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|transcription coactivator activity|vitamin D receptor binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2				OV - Ovarian serous cystadenocarcinoma(145;4.66e-08)|Epithelial(140;6.72e-08)|all cancers(34;2.22e-07)	Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)	GCTCTGCGCTCCATCGGGCTC	0.607		NaN											1	0	3.47803e-31	0.00361	3.76287e-31	72	36									
WWC3	55841	broad.mit.edu	37	X	10093067	10093067	+	Silent	SNP	C	C	T	rs11544574	byFrequency	TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chrX:10093067C>T	uc004csx.3	+	14	2028	c.1830C>T	c.(1828-1830)CGC>CGT	p.R610R	WWC3_uc010nds.2_Silent_p.R274R|WWC3_uc010ndt.2_RNA	NM_015691	NP_056506	Q9ULE0	WWC3_HUMAN	WWC family member 3	610										ovary(4)	4						TTCCTAGGCGCGACAGTGGCA	0.607		NaN											0	0	0	0.00245	0	14	27									
BMX	660	broad.mit.edu	37	X	15526533	15526533	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chrX:15526533G>C	uc004cww.2	+	2	245	c.57G>C	c.(55-57)AAG>AAC	p.K19N	BMX_uc004cwx.3_Missense_Mutation_p.K19N|BMX_uc004cwy.3_Missense_Mutation_p.K19N	NM_203281	NP_975010	P51813	BMX_HUMAN	BMX non-receptor tyrosine kinase	19	PH.				cellular component disassembly involved in apoptosis|intracellular signal transduction|mesoderm development	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			lung(3)|ovary(2)	5	Hepatocellular(33;0.183)					AGCAAAAGAAGAAAATGTCAC	0.294		NaN											0	0	0	0.00361	0	47	8									
KDM6A	7403	broad.mit.edu	37	X	44969327	44969327	+	Missense_Mutation	SNP	G	G	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chrX:44969327G>A	uc004dge.3	+	28	4384	c.4009G>A	c.(4009-4011)GAG>AAG	p.E1337K	KDM6A_uc011mkz.1_Missense_Mutation_p.E1389K|KDM6A_uc011mla.1_Missense_Mutation_p.E1292K|KDM6A_uc011mlb.1_Missense_Mutation_p.E1344K|KDM6A_uc011mlc.1_Missense_Mutation_p.E1041K|KDM6A_uc011mld.1_Missense_Mutation_p.E976K	NM_021140	NP_066963	O15550	KDM6A_HUMAN	ubiquitously transcribed tetratricopeptide	1337					histone H3-K4 methylation		metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			kidney(24)|haematopoietic_and_lymphoid_tissue(23)|oesophagus(11)|large_intestine(7)|lung(5)|breast(4)|central_nervous_system(3)|urinary_tract(3)|endometrium(2)|pancreas(2)	84						AAAACAGGTGGAGGTTTTTGA	0.348		NaN	D|N|F|S		renal|oesophageal SCC|MM								0	0	0	0.004289	0	32	11									
AFF2	2334	broad.mit.edu	37	X	148072790	148072790	+	Missense_Mutation	SNP	C	C	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chrX:148072790C>A	uc004fcp.2	+	21	4343	c.3864C>A	c.(3862-3864)AGC>AGA	p.S1288R	AFF2_uc004fcq.2_Missense_Mutation_p.S1278R|AFF2_uc004fcr.2_Missense_Mutation_p.S1249R|AFF2_uc011mxb.1_Missense_Mutation_p.S1253R|AFF2_uc004fcs.2_Missense_Mutation_p.S1253R|AFF2_uc011mxc.1_Missense_Mutation_p.S929R	NM_002025	NP_002016	P51816	AFF2_HUMAN	fragile X mental retardation 2	1288					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			ovary(3)|pancreas(2)	5	Acute lymphoblastic leukemia(192;6.56e-05)					CCCAGCACAGCAGCATGACCA	0.493		NaN											1	0	1.41595e-48	0.00361	1.54523e-48	55	97									
ATP2B3	492	broad.mit.edu	37	X	152815032	152815032	+	Silent	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chrX:152815032C>T	uc004fht.1	+	9	1542	c.1416C>T	c.(1414-1416)TCC>TCT	p.S472S	ATP2B3_uc004fhs.1_Silent_p.S472S	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	472	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCATCTGCTCCGACAAGACGG	0.607		NaN											0	0	0	0.00361	0	95	17									
UTY	7404	broad.mit.edu	37	Y	15435627	15435627	+	Missense_Mutation	SNP	G	G	C			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chrY:15435627G>C	uc004fsx.1	-	19	3798	c.2793C>G	c.(2791-2793)TTC>TTG	p.F931L	UTY_uc004fsw.1_Missense_Mutation_p.F594L|UTY_uc010nwx.1_5'UTR|UTY_uc004fsy.2_Missense_Mutation_p.F931L|UTY_uc004fsz.2_Missense_Mutation_p.F931L	NM_007125	NP_009056	O14607	UTY_HUMAN	tetratricopeptide repeat protein isoform 3	931					chromatin modification	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						TTTTGGTAGAGAAAAGTCCAA	0.318		NaN											0	0	0	0.008871	0	18	3									
UTY	7404	broad.mit.edu	37	Y	15466934	15466934	+	Silent	SNP	C	C	T			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chrY:15466934C>T	uc004fsx.1	-	15	2724	c.1719G>A	c.(1717-1719)CTG>CTA	p.L573L	UTY_uc004fsw.1_Silent_p.L236L|UTY_uc010nwx.1_5'UTR|UTY_uc004fsy.2_Silent_p.L573L|UTY_uc004fsz.2_Silent_p.L573L	NM_007125	NP_009056	O14607	UTY_HUMAN	tetratricopeptide repeat protein isoform 3	573					chromatin modification	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen				0						TGCTGCTGTTCAGGTCTGTAT	0.408		NaN											0	0	0	0.00499	0	13	8									
SLC38A2	54407	broad.mit.edu	37	12	46757539	46757540	+	Frame_Shift_Ins	INS	-	-	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr12:46757539_46757540insA	uc001rpg.2	-	12	1463_1464	c.1023_1024insT	c.(1021-1026)CTTGCCfs	p.L341fs	SLC38A2_uc010sli.1_Frame_Shift_Ins_p.L179fs|SLC38A2_uc001rph.2_Frame_Shift_Ins_p.L241fs	NM_018976	NP_061849	Q96QD8	S38A2_HUMAN	solute carrier family 38, member 2	341_342	Helical; (Potential).				cellular nitrogen compound metabolic process|glutamate secretion|neurotransmitter secretion|sodium ion transport	integral to membrane|plasma membrane	amino acid transmembrane transporter activity|symporter activity			urinary_tract(1)|skin(1)	2	Lung SC(27;0.192)|Renal(347;0.236)		OV - Ovarian serous cystadenocarcinoma(5;0.0048)|Epithelial(2;0.0374)	GBM - Glioblastoma multiforme(48;0.226)		AAGAGGGCGGCAAGCAGATACA	0.332		NaN											NaN	NaN	NaN	NaN	NaN	49	46	---	---							
LRCH1	23143	broad.mit.edu	37	13	47243183	47243186	+	Frame_Shift_Del	DEL	CCTG	CCTG	-			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr13:47243183_47243186delCCTG	uc001vbj.2	+	3	707_710	c.471_474delCCTG	c.(469-474)GCCCTGfs	p.A157fs	LRCH1_uc010acp.2_Frame_Shift_Del_p.A157fs|LRCH1_uc001vbk.2_Frame_Shift_Del_p.A157fs|LRCH1_uc001vbl.3_Frame_Shift_Del_p.A157fs	NM_015116	NP_055931	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH)	157_158	LRR 3.									ovary(1)|central_nervous_system(1)	2		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		AGCTGTCCGCCCTGCCTGCCTGCC	0.436		NaN											NaN	NaN	NaN	NaN	NaN	7	318	---	---							
THSD4	79875	broad.mit.edu	37	15	72039168	72039176	+	Splice_Site	DEL	CTGAACCAG	CTGAACCAG	-			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr15:72039168_72039176delCTGAACCAG	uc002atb.1	+	12	2116	c.2037_splice	c.e12-1	p.F679_splice	THSD4_uc002ate.2_Splice_Site_p.F319_splice	NM_024817	NP_079093	Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4							proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2						TCTCTCATTCCTGAACCAGCTGGGACATC	0.584		NaN											NaN	NaN	NaN	NaN	NaN	12	101	---	---							
MKL2	57496	broad.mit.edu	37	16	14354763	14354764	+	Splice_Site	INS	-	-	A			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr16:14354763_14354764insA	uc010uza.1	+	17	2920	c.2765_splice	c.e17-2	p.E922_splice	MKL2_uc002dcg.2_Splice_Site_p.E872_splice|MKL2_uc002dcj.2_Splice_Site_p.E167_splice	NM_014048	NP_054767	Q9ULH7	MKL2_HUMAN	megakaryoblastic leukemia 2 protein						cell differentiation|muscle organ development|positive regulation of striated muscle tissue development|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent		identical protein binding|nucleic acid binding|transcription coactivator activity			ovary(3)|kidney(1)|pancreas(1)	5						TTATTTTACACAGAGATCTCCC	0.361		NaN											NaN	NaN	NaN	NaN	NaN	27	81	---	---							
FBXW9	84261	broad.mit.edu	37	19	12800930	12800931	+	In_Frame_Ins	INS	-	-	GAA			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr19:12800930_12800931insGAA	uc010dyx.2	-	6	937_938	c.937_938insTTC	c.(937-939)CAT>CTTCAT	p.312_313insL	FBXW9_uc010xmp.1_Intron|uc002mul.1_3'UTR|FBXW9_uc002mum.1_Intron|FBXW9_uc002mun.1_Intron	NM_032301	NP_115677	Q5XUX1	FBXW9_HUMAN	F-box and WD-40 domain protein 9	322_323							protein binding			ovary(1)	1						GCCGGCTTCATGGGTGATGGGC	0.634		NaN											NaN	NaN	NaN	NaN	NaN	23	109	---	---							
ASXL2	55252	broad.mit.edu	37	2	26022304	26022306	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr2:26022304_26022306delCTG	uc002rgs.2	-	4	572_574	c.351_353delCAG	c.(349-354)AGCAGT>AGT	p.117_118SS>S		NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	117_118	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GCCACCATCACTGCTGCTGCTGC	0.463		NaN											NaN	NaN	NaN	NaN	NaN	7	312	---	---							
LNP1	348801	broad.mit.edu	37	3	100148586	100148588	+	In_Frame_Del	DEL	GAT	GAT	-			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr3:100148586_100148588delGAT	uc003dtx.3	+	2	1293_1295	c.13_15delGAT	c.(13-15)GATdel	p.D10del	LNP1_uc003dty.3_RNA|LNP1_uc011bhb.1_RNA	NM_001085451	NP_001078920	A1A4G5	LNP1_HUMAN	leukemia NUP98 fusion partner 1	10	Poly-Asp.										0						GGAGCACAAAGATGATGATGATG	0.507		NaN											NaN	NaN	NaN	NaN	NaN	9	695	---	---							
MFSD10	10227	broad.mit.edu	37	4	2932969	2932969	+	Frame_Shift_Del	DEL	C	C	-			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr4:2932969delC	uc003gfw.2	-	10	1461	c.1147delG	c.(1147-1149)GTGfs	p.V383fs	MFSD10_uc003gfv.2_Frame_Shift_Del_p.V73fs|MFSD10_uc003gfx.2_Frame_Shift_Del_p.V207fs|MFSD10_uc003gfz.2_Frame_Shift_Del_p.V383fs|MFSD10_uc003gfy.2_RNA|MFSD10_uc003gga.2_Frame_Shift_Del_p.P346fs|MFSD10_uc003ggb.1_Frame_Shift_Del_p.V383fs|MFSD10_uc003ggc.2_Intron	NM_001120	NP_001111	Q14728	MFS10_HUMAN	major facilitator superfamily domain containing	383					apoptosis	integral to membrane	tetracycline transporter activity				0				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CCAGCGACCACGGAGGACAGG	0.692		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---							
HHIP	64399	broad.mit.edu	37	4	145567851	145567853	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr4:145567851_145567853delGCT	uc003ijs.1	+	1	679_681	c.24_26delGCT	c.(22-27)AAGCTG>AAG	p.L12del	uc003ijq.1_5'Flank|HHIP_uc003ijr.1_In_Frame_Del_p.L12del	NM_022475	NP_071920	Q96QV1	HHIP_HUMAN	hedgehog-interacting protein precursor	12						cytoplasm|extracellular region	catalytic activity|protein binding|zinc ion binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.0185)		TCTCCTTTAAGCTGCTGCTGCTG	0.621		NaN									OREG0016346	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	NaN	NaN	NaN	NaN	NaN	7	536	---	---							
RP1L1	94137	broad.mit.edu	37	8	10467629	10467630	+	In_Frame_Ins	INS	-	-	TTC	rs146656804	by1000genomes	TCGA-GV-A3QH-01A-11D-A21Z-08	TCGA-GV-A3QH-10A-01D-A21Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	e4ff90f4-7122-475a-84a6-a39cd56c7e46	639c8ae6-127a-474d-b66a-c4a6da661cd7	g.chr8:10467629_10467630insTTC	uc003wtc.2	-	4	4207_4208	c.3978_3979insGAA	c.(3976-3981)insGAA	p.1326_1327insE		NM_178857	NP_849188	Q8IWN7	RP1L1_HUMAN	retinitis pigmentosa 1-like 1	1326_1327					intracellular signal transduction					ovary(4)|breast(3)|central_nervous_system(1)	8				COAD - Colon adenocarcinoma(149;0.0811)		ccttcttctgttttagtttcct	0.084		NaN											NaN	NaN	NaN	NaN	NaN	4	5	---	---							
