Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
MTHFR	4524	broad.mit.edu	37	1	11854118	11854118	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr1:11854118G>A	uc001atc.1	-	9	1560	c.1376C>T	c.(1375-1377)CCC>CTC	p.P459L	MTHFR_uc001atb.1_Missense_Mutation_p.P482L	NM_005957	NP_005948	P42898	MTHR_HUMAN	5,10-methylenetetrahydrofolate reductase	459					blood circulation|folic acid metabolic process	cytosol	methylenetetrahydrofolate reductase (NADPH) activity|protein binding				0	Ovarian(185;0.249)	Lung NSC(185;8.69e-05)|all_lung(284;9.87e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00826)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.66e-06)|COAD - Colon adenocarcinoma(227;0.000261)|BRCA - Breast invasive adenocarcinoma(304;0.000304)|Kidney(185;0.000777)|KIRC - Kidney renal clear cell carcinoma(229;0.00261)|STAD - Stomach adenocarcinoma(313;0.0073)|READ - Rectum adenocarcinoma(331;0.0649)	Benazepril(DB00542)|Cyanocobalamin(DB00115)|Folic Acid(DB00158)|L-Methionine(DB00134)|Menadione(DB00170)|Methotrexate(DB00563)|Pyridoxal Phosphate(DB00114)|Pyridoxine(DB00165)|Raltitrexed(DB00293)|Riboflavin(DB00140)|S-Adenosylmethionine(DB00118)|Tetrahydrofolic acid(DB00116)	AGCCGCCAGGGGCTCATCGTT	0.647000													45	65					0	0	0.014410	0	0
ARID1A	8289	broad.mit.edu	37	1	27106648	27106648	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr1:27106648G>A	uc001bmv.1	+	20	6632	c.6259G>A	c.(6259-6261)GGA>AGA	p.G2087R	ARID1A_uc001bmu.1_Missense_Mutation_p.G1870R|ARID1A_uc001bmx.1_Missense_Mutation_p.G933R|ARID1A_uc009vsm.1_Missense_Mutation_p.G415R|ARID1A_uc009vsn.1_Missense_Mutation_p.G329R	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	2087	LXXLL.				androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TGTCCTGGACGGACTCCTACA	0.592000			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								43	87					0	0	0.009718	0	0
CYP4Z2P	163720	broad.mit.edu	37	1	47338925	47338925	+	RNA	SNP	C	G	G			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr1:47338925C>G	uc001cqo.1	-	7		c.908G>C			CYP4Z2P_uc009vyn.1_RNA	NR_002788				Homo sapiens cDNA FLJ40054 fis, clone TBAES2000315, weakly similar to CYTOCHROME P450 4A1 (EC 1.14.15.3).												0						CTTTGGCACTCAAAAGTATGT	0.289000													20	32					0	0	0.010504	0	0
RPAP2	79871	broad.mit.edu	37	1	92798963	92798963	+	Missense_Mutation	SNP	C	G	G			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr1:92798963C>G	uc001dot.2	+	9	1580	c.1471C>G	c.(1471-1473)CCA>GCA	p.P491A	RPAP2_uc009wdh.2_RNA	NM_024813	NP_079089	Q8IXW5	RPAP2_HUMAN	RNA polymerase II associated protein 2	491						integral to membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)	1		all_lung(203;0.0565)|Lung NSC(277;0.152)|Glioma(108;0.222)		all cancers(265;0.00647)|GBM - Glioblastoma multiforme(16;0.0234)|Epithelial(280;0.115)		TTCCACCTTTCCACTGATAGA	0.333000													45	73					0	0	0.011902	0	0
CD244	51744	broad.mit.edu	37	1	160811119	160811119	+	Missense_Mutation	SNP	T	C	C			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr1:160811119T>C	uc009wtq.2	-	3	729	c.551A>G	c.(550-552)TAC>TGC	p.Y184C	CD244_uc001fxa.2_Missense_Mutation_p.Y179C|CD244_uc009wtp.2_RNA|CD244_uc009wtr.2_Intron|CD244_uc010pjt.1_RNA	NM_016382	NP_057466	Q9BZW8	CD244_HUMAN	CD244 natural killer cell receptor 2B4	184	Extracellular (Potential).|Ig-like 2.				blood coagulation|leukocyte migration	integral to membrane|plasma membrane	protein binding|receptor activity			ovary(1)	1	all_cancers(52;2.72e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00737)			CTCGTCCAGGTAGGTGAGGTT	0.522000													65	123					0	0	0.014410	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232626797	232626797	+	Silent	SNP	C	T	T			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr1:232626797C>T	uc001hvg.2	-	3	1787	c.1629G>A	c.(1627-1629)CTG>CTA	p.L543L		NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	signal-induced proliferation-associated 1 like	543					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(2)|central_nervous_system(2)|pancreas(1)|skin(1)	6		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				TTGCTCCTCTCAGTGTTGTAA	0.428000													25	20					0	0	0.003954	0	0
ZNF438	220929	broad.mit.edu	37	10	31138795	31138795	+	Missense_Mutation	SNP	G	A	A	rs138921820		TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr10:31138795G>A	uc010qdz.1	-	7	974	c.539C>T	c.(538-540)CCA>CTA	p.P180L	ZNF438_uc001ivn.2_Missense_Mutation_p.P131L|ZNF438_uc010qdy.1_Missense_Mutation_p.P170L|ZNF438_uc001ivo.3_Intron|ZNF438_uc009xlg.2_Missense_Mutation_p.P180L|ZNF438_uc001ivp.3_Missense_Mutation_p.P170L|ZNF438_uc010qea.1_Missense_Mutation_p.P180L|ZNF438_uc010qeb.1_Missense_Mutation_p.P180L|ZNF438_uc010qec.1_Intron	NM_182755	NP_877432	Q7Z4V0	ZN438_HUMAN	zinc finger protein 438 isoform a	180					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|breast(1)	2		Prostate(175;0.0587)				CTCTAGTGATGGTACTTCCTC	0.547000													6	225					0	0	0.001168	0	0
CTNNA3	29119	broad.mit.edu	37	10	68280427	68280427	+	Silent	SNP	G	A	A			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr10:68280427G>A	uc009xpn.1	-	11	1602	c.1479C>T	c.(1477-1479)CTC>CTT	p.L493L	CTNNA3_uc001jmw.2_Silent_p.L493L|CTNNA3_uc001jmx.3_Silent_p.L493L	NM_001127384	NP_001120856	Q9UI47	CTNA3_HUMAN	catenin, alpha 3	493					cell-cell adhesion	actin cytoskeleton|cytoplasm|fascia adherens	cadherin binding|structural molecule activity			skin(3)|ovary(2)|pancreas(1)|lung(1)|central_nervous_system(1)	8						CGGCTTCAGTGAGGACATGTA	0.368000													127	75					0	0	0.014410	0	0
SLC22A8	9376	broad.mit.edu	37	11	62762218	62762218	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr11:62762218C>T	uc001nwo.2	-	8	1148	c.1012G>A	c.(1012-1014)GGT>AGT	p.G338S	SLC22A8_uc001nwn.1_3'UTR|SLC22A8_uc001nwp.2_Missense_Mutation_p.G338S|SLC22A8_uc009yom.2_Missense_Mutation_p.G215S|SLC22A8_uc010rmm.1_Missense_Mutation_p.G247S|SLC22A8_uc009yon.2_Missense_Mutation_p.G338S	NM_004254	NP_004245	Q8TCC7	S22A8_HUMAN	solute carrier family 22 member 8	338	Helical; (Potential).				response to toxin	basolateral plasma membrane|integral to plasma membrane|membrane fraction	inorganic anion exchanger activity|organic anion transmembrane transporter activity			skin(2)|ovary(1)	3						TAGGCAAAACCGGTAGCAAAC	0.488000													28	41					0	0	0.007291	0	0
THY1	7070	broad.mit.edu	37	11	119290224	119290224	+	Missense_Mutation	SNP	A	C	C	rs147718110		TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr11:119290224A>C	uc001pwq.2	-	3	414	c.380T>G	c.(379-381)CTG>CGG	p.L127R	uc001pwo.2_Intron|uc001pwp.1_Intron|THY1_uc001pwr.2_Missense_Mutation_p.L127R|THY1_uc001pws.2_RNA	NM_006288	NP_006279	P04216	THY1_HUMAN	Thy-1 cell surface antigen preproprotein	127					angiogenesis|cell-cell adhesion|cytoskeleton organization|focal adhesion assembly|negative regulation of axonogenesis|negative regulation of cell migration|negative regulation of protein kinase activity|negative regulation of T cell receptor signaling pathway|positive regulation of release of sequestered calcium ion into cytosol|positive regulation of T cell activation|retinal cone cell development|T cell receptor signaling pathway	endoplasmic reticulum|growth cone|integral to plasma membrane|membrane raft	GPI anchor binding|integrin binding|Rho GTPase activator activity				0		Medulloblastoma(222;0.0523)|Breast(348;0.174)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;3.83e-05)		ACACTTGACCAGTTTGTCTGC	0.602000													32	29					0	0	0.003271	0	0
TAS2R19	259294	broad.mit.edu	37	12	11174585	11174585	+	Missense_Mutation	SNP	G	C	C			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr12:11174585G>C	uc010shj.1	-	1	586	c.586C>G	c.(586-588)CTG>GTG	p.L196V	PRR4_uc009zhp.2_Intron|PRH1_uc001qzb.3_Intron|PRH1_uc001qzc.2_Intron|PRB4_uc001qzf.1_Intron|PRH1_uc001qzj.2_Intron	NM_176888	NP_795369	P59542	T2R19_HUMAN	taste receptor, type 2, member 19	196	Helical; Name=5; (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			skin(1)	1						ATTAACAGCAGAAAACATATT	0.403000													99	83					0	0	0.014410	0	0
LRP6	4040	broad.mit.edu	37	12	12337018	12337018	+	Missense_Mutation	SNP	C	G	G			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr12:12337018C>G	uc001rah.3	-	5	1014	c.872G>C	c.(871-873)GGG>GCG	p.G291A	BCL2L14_uc001raf.1_Intron|LRP6_uc010shl.1_Missense_Mutation_p.G291A	NM_002336	NP_002327	O75581	LRP6_HUMAN	low density lipoprotein receptor-related protein	291	Extracellular (Potential).|EGF-like 1.				cellular response to cholesterol|negative regulation of protein phosphorylation|negative regulation of protein serine/threonine kinase activity|negative regulation of smooth muscle cell apoptosis|neural crest formation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell cycle|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway involved in dorsal/ventral axis specification|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	cell surface|cytoplasmic vesicle|endoplasmic reticulum|integral to membrane|plasma membrane	coreceptor activity|frizzled binding|kinase inhibitor activity|low-density lipoprotein receptor activity|protein homodimerization activity|toxin transporter activity|Wnt-protein binding			lung(4)|skin(4)|ovary(2)|kidney(1)|central_nervous_system(1)	12		Prostate(47;0.0865)				GGAACAACCCCCATTGTCAAT	0.388000													31	64					0	0	0.013726	0	0
EIF4B	1975	broad.mit.edu	37	12	53421858	53421858	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr12:53421858G>A	uc001sbh.3	+	8	1071	c.865G>A	c.(865-867)GAT>AAT	p.D289N	EIF4B_uc010snu.1_Missense_Mutation_p.D289N|EIF4B_uc010snv.1_Missense_Mutation_p.D250N|EIF4B_uc001sbi.2_Missense_Mutation_p.D41N	NM_001417	NP_001408	P23588	IF4B_HUMAN	eukaryotic translation initiation factor 4B	289	Arg-rich.|Asp-rich.				insulin receptor signaling pathway|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	nucleotide binding|translation initiation factor activity			breast(1)|kidney(1)	2						TCGCAGGGATGATGACTACAG	0.502000													27	67					0	0	0.004656	0	0
KLHL1	57626	broad.mit.edu	37	13	70681587	70681587	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr13:70681587G>A	uc001vip.2	-	1	1039	c.245C>T	c.(244-246)CCG>CTG	p.P82L	KLHL1_uc010thm.1_Missense_Mutation_p.P82L|ATXN8OS_uc010aej.1_RNA	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	82	Ser-rich.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		ggaagaggacggggaggacga	0.453000													35	51					0	0	0.003271	0	0
PSEN1	5663	broad.mit.edu	37	14	73637568	73637568	+	Missense_Mutation	SNP	T	C	C			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr14:73637568T>C	uc001xnr.2	+	4	435	c.151T>C	c.(151-153)TCT>CCT	p.S51P	PSEN1_uc001xnv.2_Missense_Mutation_p.S47P|PSEN1_uc010ark.2_Missense_Mutation_p.S47P|PSEN1_uc001xnt.1_RNA|PSEN1_uc001xnu.2_RNA|PSEN1_uc001xnq.3_Missense_Mutation_p.S51P	NM_000021	NP_000012	P49768	PSN1_HUMAN	presenilin 1 isoform I-467	51	Cytoplasmic (Potential).				amyloid precursor protein catabolic process|anti-apoptosis|beta-amyloid metabolic process|cell-cell adhesion|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|smooth endoplasmic reticulum calcium ion homeostasis	apical plasma membrane|axon|cell cortex|cell surface|centrosome|ciliary rootlet|dendritic shaft|endoplasmic reticulum membrane|gamma-secretase complex|Golgi membrane|growth cone|integral to plasma membrane|kinetochore|lysosomal membrane|membrane raft|mitochondrial inner membrane|neuromuscular junction|neuronal cell body|nuclear outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum|smooth endoplasmic reticulum|Z disc	aspartic-type endopeptidase activity|beta-catenin binding|cadherin binding|calcium channel activity|PDZ domain binding			breast(1)|kidney(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00394)|OV - Ovarian serous cystadenocarcinoma(108;0.075)		TGAGCCATTATCTAATGGACG	0.478000													17	28					0	0	0.004007	0	0
CYFIP1	23191	broad.mit.edu	37	15	22990062	22990062	+	Silent	SNP	G	A	A			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr15:22990062G>A	uc001yus.2	+	24	2786	c.2682G>A	c.(2680-2682)TTG>TTA	p.L894L	CYFIP1_uc001yut.2_Silent_p.L894L|CYFIP1_uc010aya.1_Silent_p.L922L|CYFIP1_uc001yuu.2_Silent_p.L463L|CYFIP1_uc001yuv.2_Silent_p.L88L	NM_014608	NP_055423	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1 isoform	894					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			ovary(4)|pancreas(3)|liver(1)|skin(1)	9		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		TCCAGGCTTTGAACTTGGCCT	0.547000													27	93					0	0	0.013726	0	0
MYO5A	4644	broad.mit.edu	37	15	52645812	52645812	+	Missense_Mutation	SNP	T	C	C			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr15:52645812T>C	uc002aby.2	-	27	3855	c.3611A>G	c.(3610-3612)GAG>GGG	p.E1204G	MYO5A_uc002abx.3_Missense_Mutation_p.E1204G|MYO5A_uc010ugd.1_5'Flank|MYO5A_uc002aca.1_5'Flank|MYO5A_uc002acb.1_5'Flank|MYO5A_uc002acc.1_5'Flank	NM_000259	NP_000250	Q9Y4I1	MYO5A_HUMAN	myosin VA isoform 1	1204	Potential.				actin filament-based movement|transport	cytoplasm|growth cone|myosin complex|ruffle	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(3)|central_nervous_system(1)	4				all cancers(107;0.0085)|Colorectal(133;0.077)|READ - Rectum adenocarcinoma(133;0.196)		CTTGAGTGACTCATATTCCAG	0.348000													3	114					0	0	0.004672	0	0
KIAA1370	56204	broad.mit.edu	37	15	52901518	52901518	+	Silent	SNP	C	T	T			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr15:52901518C>T	uc002acg.3	-	6	1746	c.1593G>A	c.(1591-1593)TTG>TTA	p.L531L	KIAA1370_uc002ach.3_RNA|KIAA1370_uc010bfg.1_Silent_p.L443L|KIAA1370_uc010ugf.1_Silent_p.L538L	NM_019600	NP_062546	Q32MH5	K1370_HUMAN	hypothetical protein LOC56204	531											0				all cancers(107;0.0803)		TATTTTTCTTCAACAAATTTT	0.378000													74	51					0	0	0.014410	0	0
Unknown	0	broad.mit.edu	37	16	21854826	21854826	+	Silent	SNP	G	A	A			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr16:21854826G>A	uc002djr.3	-	6	608	c.426C>T	c.(424-426)GTC>GTT	p.V142V	uc002djs.3_RNA|uc002djq.3_Silent_p.V123V|uc010vbn.1_Silent_p.V142V	NM_130464	NP_569731			nuclear pore complex interacting protein-like 3																		GTAGAGTAATGACGTCTTTCA	0.398000													94	304					0	0	0.014410	0	0
HTA	283902	broad.mit.edu	37	16	73126796	73126796	+	RNA	SNP	G	A	A			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr16:73126796G>A	uc010vmq.1	+	1		c.549G>A				NR_027756				Homo sapiens cDNA clone IMAGE:4544545, partial cds.												0						TGTGTCCCACGCGCTCCTGTT	0.527000													11	31					0	0	0.008291	0	0
PITPNM3	83394	broad.mit.edu	37	17	6387600	6387600	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr17:6387600C>T	uc002gdd.3	-	5	438	c.287G>A	c.(286-288)CGG>CAG	p.R96Q	PITPNM3_uc010cln.2_Missense_Mutation_p.R60Q|PITPNM3_uc002gdc.3_5'Flank	NM_031220	NP_112497	Q9BZ71	PITM3_HUMAN	PITPNM family member 3 isoform 1	96					phosphatidylinositol metabolic process	endomembrane system|integral to membrane	calcium ion binding|lipid binding|phosphatidylinositol transporter activity|receptor tyrosine kinase binding			ovary(2)|central_nervous_system(2)	4				Colorectal(2;0.000372)|READ - Rectum adenocarcinoma(2;0.0276)|LUAD - Lung adenocarcinoma(2;0.0836)|COAD - Colon adenocarcinoma(228;0.185)		CAAGGAAACCCGGTACAGTTC	0.597000													49	96					0	0	0.014410	0	0
NEURL4	84461	broad.mit.edu	37	17	7230490	7230490	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr17:7230490G>A	uc002gga.1	-	3	794	c.787C>T	c.(787-789)CAT>TAT	p.H263Y	NEURL4_uc002ggb.1_Missense_Mutation_p.H263Y|NEURL4_uc002ggc.1_5'Flank	NM_032442	NP_115818	Q96JN8	NEUL4_HUMAN	neuralized homolog 4 isoform 1	263							protein binding			upper_aerodigestive_tract(1)|ovary(1)	2						TCACCATTATGCGACTCAAGG	0.632000													12	15					0	0	0.010729	0	0
CCL23	6368	broad.mit.edu	37	17	34340828	34340828	+	Missense_Mutation	SNP	C	G	G			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr17:34340828C>G	uc002hkt.1	-	3	278	c.207G>C	c.(205-207)GAG>GAC	p.E69D	CCL23_uc002hks.1_Missense_Mutation_p.E86D	NM_145898	NP_665905	P55773	CCL23_HUMAN	small inducible cytokine A23 isoform CKbeta8	69					cell-cell signaling|cellular calcium ion homeostasis|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|negative regulation of cell proliferation	extracellular space	chemokine activity|heparin binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)	Treprostinil(DB00374)	CAAAGTAACTCTCCAGGAGTG	0.522000													38	31					0	0	0.006230	0	0
CCL23	6368	broad.mit.edu	37	17	34340871	34340871	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr17:34340871C>T	uc002hkt.1	-	3	235	c.164G>A	c.(163-165)TGC>TAC	p.C55Y	CCL23_uc002hks.1_Missense_Mutation_p.C72Y	NM_145898	NP_665905	P55773	CCL23_HUMAN	small inducible cytokine A23 isoform CKbeta8	55					cell-cell signaling|cellular calcium ion homeostasis|chemotaxis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|negative regulation of cell proliferation	extracellular space	chemokine activity|heparin binding				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)	Treprostinil(DB00374)	GTAGGAGATGCAGCAGTCAGC	0.537000													38	39					0	0	0.005524	0	0
SEC14L1	6397	broad.mit.edu	37	17	75186917	75186917	+	Silent	SNP	G	A	A			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr17:75186917G>A	uc002jto.2	+	4	363	c.96G>A	c.(94-96)TTG>TTA	p.L32L	SEC14L1_uc010dhc.2_Silent_p.L32L|SEC14L1_uc010wth.1_Silent_p.L32L|SEC14L1_uc002jtm.2_Silent_p.L32L|SEC14L1_uc010wti.1_5'UTR	NM_003003	NP_002994	Q92503	S14L1_HUMAN	SEC14 (S. cerevisiae)-like 1 isoform a	32	PRELI/MSF1.				transport	Golgi apparatus|integral to membrane	binding			ovary(2)	2						CATGTCCTTTGATTCCGATGT	0.458000													60	110					0	0	0.014410	0	0
SMAD4	4089	broad.mit.edu	37	18	48575080	48575080	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr18:48575080C>T	uc010xdp.1	+	3	812	c.274C>T	c.(274-276)CAT>TAT	p.H92Y	SMAD4_uc010xdo.1_RNA	NM_005359	NP_005350	Q13485	SMAD4_HUMAN	mothers against decapentaplegic homolog 4	92	MH1.				BMP signaling pathway|negative regulation of cell growth|negative regulation of protein catabolic process|negative regulation of transcription, DNA-dependent|palate development|positive regulation of epithelial to mesenchymal transition|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of SMAD protein import into nucleus|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of transforming growth factor-beta2 production|response to hypoxia|response to transforming growth factor beta stimulus|SMAD protein complex assembly|SMAD protein signal transduction|transforming growth factor beta receptor signaling pathway	activin responsive factor complex|centrosome|cytosol	I-SMAD binding|protein homodimerization activity|R-SMAD binding|transcription regulatory region DNA binding|transforming growth factor beta receptor, common-partner cytoplasmic mediator activity	p.0?(35)|p.?(4)		pancreas(170)|large_intestine(108)|thyroid(19)|lung(11)|small_intestine(9)|upper_aerodigestive_tract(8)|biliary_tract(8)|ovary(7)|breast(6)|stomach(5)|oesophagus(3)|testis(2)|central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|gastrointestinal_tract_(site_indeterminate)(2)|liver(2)|kidney(1)|urinary_tract(1)|vulva(1)|skin(1)|NS(1)	369		all_cancers(7;0.203)|Colorectal(6;0.003)|all_epithelial(6;0.00336)		Colorectal(16;0.0032)|COAD - Colon adenocarcinoma(17;0.0708)|READ - Rectum adenocarcinoma(32;0.155)		AGGATTTCCTCATGTGATCTA	0.264000									Juvenile_Polyposis|Hereditary_Hemorrhagic_Telangiectasia				39	13					0	0	0.008740	0	0
OLFM2	93145	broad.mit.edu	37	19	9965242	9965242	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr19:9965242C>T	uc002mmp.2	-	6	1013	c.985G>A	c.(985-987)GAG>AAG	p.E329K	OLFM2_uc002mmo.2_Missense_Mutation_p.E251K	NM_058164	NP_477512	O95897	NOE2_HUMAN	olfactomedin 2 precursor	329	Olfactomedin-like.					extracellular region				large_intestine(1)|skin(1)	2						AGCCCGCTCTCGTCCACCATG	0.652000													25	38					0	0	0.003330	0	0
SLC1A6	6511	broad.mit.edu	37	19	15083604	15083604	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr19:15083604C>T	uc002naa.1	-	1	127	c.119G>A	c.(118-120)CGC>CAC	p.R40H	SLC1A6_uc010dzu.1_Missense_Mutation_p.R40H|SLC1A6_uc010xod.1_Silent_p.A44A|SLC1A6_uc002nab.2_Missense_Mutation_p.R40H|SLC1A6_uc002nac.2_Missense_Mutation_p.R40H|SLC1A6_uc002nad.1_Missense_Mutation_p.R40H	NM_005071	NP_005062	P48664	EAA4_HUMAN	solute carrier family 1 (high affinity	40	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|L-aspartate transmembrane transporter activity|sodium:dicarboxylate symporter activity			pancreas(3)|ovary(2)|skin(1)	6					L-Glutamic Acid(DB00142)	GGTCTGCAGGCGCAGGCGCGT	0.682000													3	16					0	0	0.004672	0	0
ZNF536	9745	broad.mit.edu	37	19	30935510	30935510	+	Silent	SNP	C	T	T			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr19:30935510C>T	uc002nsu.1	+	2	1179	c.1041C>T	c.(1039-1041)TGC>TGT	p.C347C	ZNF536_uc010edd.1_Silent_p.C347C	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	347	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					AGTTCCGCTGCGAGGTGTGCG	0.652000													48	78					0	0	0.013114	0	0
VN1R1	57191	broad.mit.edu	37	19	57967234	57967234	+	Nonsense_Mutation	SNP	G	T	T			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr19:57967234G>T	uc002qos.1	-	1	621	c.621C>A	c.(619-621)TAC>TAA	p.Y207*	ZNF547_uc002qpm.3_Intron	NM_020633	NP_065684	Q9GZP7	VN1R1_HUMAN	vomeronasal 1 receptor 1	207	Extracellular (Potential).				response to pheromone	integral to membrane|plasma membrane	pheromone receptor activity			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0694)|Renal(1328;0.157)|Breast(46;0.222)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0254)|Lung(386;0.171)		TGTAAGAACAGTATCCATAAT	0.408000													5	86					2.17888e-05	2.42097e-05	0.006214	1	0
AOX1	316	broad.mit.edu	37	2	201507422	201507422	+	Silent	SNP	A	C	C			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr2:201507422A>C	uc002uvx.2	+	25	2846	c.2745A>C	c.(2743-2745)CCA>CCC	p.P915P	AOX1_uc010zhf.1_Silent_p.P471P|AOX1_uc010fsu.2_Silent_p.P281P	NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	915					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	CCAACCTTCCATCCAACACAG	0.498000													19	61					0	0	0.007413	0	0
FN1	2335	broad.mit.edu	37	2	216272840	216272840	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr2:216272840G>A	uc002vfa.2	-	17	2775	c.2509C>T	c.(2509-2511)CCC>TCC	p.P837S	FN1_uc002vfb.2_Missense_Mutation_p.P837S|FN1_uc002vfc.2_Missense_Mutation_p.P837S|FN1_uc002vfd.2_Missense_Mutation_p.P837S|FN1_uc002vfe.2_Missense_Mutation_p.P837S|FN1_uc002vff.2_Missense_Mutation_p.P837S|FN1_uc002vfg.2_Missense_Mutation_p.P837S|FN1_uc002vfh.2_Missense_Mutation_p.P837S|FN1_uc002vfi.2_Missense_Mutation_p.P837S|FN1_uc002vfj.2_Missense_Mutation_p.P837S	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	837	Fibronectin type-III 3.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CCTGTGATGGGAGCCTGGGGT	0.527000													75	42					0	0	0.014410	0	0
FN1	2335	broad.mit.edu	37	2	216272872	216272872	+	Nonsense_Mutation	SNP	G	C	C			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr2:216272872G>C	uc002vfa.2	-	17	2743	c.2477C>G	c.(2476-2478)TCA>TGA	p.S826*	FN1_uc002vfb.2_Nonsense_Mutation_p.S826*|FN1_uc002vfc.2_Nonsense_Mutation_p.S826*|FN1_uc002vfd.2_Nonsense_Mutation_p.S826*|FN1_uc002vfe.2_Nonsense_Mutation_p.S826*|FN1_uc002vff.2_Nonsense_Mutation_p.S826*|FN1_uc002vfg.2_Nonsense_Mutation_p.S826*|FN1_uc002vfh.2_Nonsense_Mutation_p.S826*|FN1_uc002vfi.2_Nonsense_Mutation_p.S826*|FN1_uc002vfj.2_Nonsense_Mutation_p.S826*	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	826	Fibronectin type-III 3.				acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AACAACAATTGAGGTGTCATC	0.522000													73	55					0	0	0.014410	0	0
CDC42EP1	11135	broad.mit.edu	37	22	37964251	37964251	+	Silent	SNP	C	T	T			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr22:37964251C>T	uc003asz.3	+	3	1003	c.600C>T	c.(598-600)CTC>CTT	p.L200L		NM_152243	NP_689449	Q00587	BORG5_HUMAN	CDC42 effector protein 1	200					positive regulation of pseudopodium assembly|regulation of cell shape	actin cytoskeleton|endomembrane system|Golgi apparatus|plasma membrane	protein binding				0	Melanoma(58;0.0574)					GCCTGGACCTCGACCTTGGGC	0.667000													57	56					0	0	0.014410	0	0
BSN	8927	broad.mit.edu	37	3	49689805	49689805	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr3:49689805C>T	uc003cxe.3	+	5	2930	c.2816C>T	c.(2815-2817)ACG>ATG	p.T939M		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	939					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		CTCAACAGCACGGGAAGTTAT	0.632000													4	103					0	0	0.009096	0	0
CBLB	868	broad.mit.edu	37	3	105464807	105464807	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr3:105464807C>T	uc003dwc.2	-	6	1121	c.799G>A	c.(799-801)GAT>AAT	p.D267N	CBLB_uc011bhi.1_Missense_Mutation_p.D289N|CBLB_uc003dwd.1_Missense_Mutation_p.D267N|CBLB_uc003dwe.1_Missense_Mutation_p.D267N|CBLB_uc011bhj.1_RNA	NM_170662	NP_733762	Q13191	CBLB_HUMAN	Cas-Br-M (murine) ecotropic retroviral	267	Cbl-PTB.|SH2-like.				cell surface receptor linked signaling pathway|NLS-bearing substrate import into nucleus	cytoplasm|nucleus	calcium ion binding|ligase activity|signal transducer activity|zinc ion binding			lung(4)|ovary(3)|breast(1)|skin(1)	9						TTAACTTCATCATATGTGAGA	0.343000			Mis S		AML								92	145					0	0	0.014410	0	0
C3orf15	89876	broad.mit.edu	37	3	119462963	119462963	+	Missense_Mutation	SNP	C	T	T	rs139653997		TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr3:119462963C>T	uc003ede.3	+	14	1899	c.1822C>T	c.(1822-1824)CGG>TGG	p.R608W	C3orf15_uc010hqz.2_Missense_Mutation_p.R546W|C3orf15_uc011bjd.1_Missense_Mutation_p.R482W|C3orf15_uc011bje.1_Missense_Mutation_p.R588W	NM_033364	NP_203528	Q7Z4T9	AAT1_HUMAN	AAT1-alpha	444						mitochondrion	protein binding			ovary(2)|pancreas(1)	3				GBM - Glioblastoma multiforme(114;0.186)		GCGCCAGCGGCGGGTACGAGA	0.587000													39	54					0	0	0.009718	0	0
GK5	256356	broad.mit.edu	37	3	141900366	141900366	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr3:141900366C>T	uc003euq.1	-	11	1116	c.985G>A	c.(985-987)GTA>ATA	p.V329I	GK5_uc003eup.1_Missense_Mutation_p.V50I|GK5_uc010hus.1_RNA	NM_001039547	NP_001034636	Q6ZS86	GLPK5_HUMAN	glycerol kinase 5 (putative)	329					glycerol metabolic process		ATP binding|glycerol kinase activity				0						GCTAAGCATACGACTTCTTGC	0.383000													49	68					0	0	0.014410	0	0
BOD1L	259282	broad.mit.edu	37	4	13600774	13600774	+	Missense_Mutation	SNP	T	C	C			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr4:13600774T>C	uc003gmz.1	-	10	7867	c.7750A>G	c.(7750-7752)ATG>GTG	p.M2584V	BOD1L_uc010idr.1_Missense_Mutation_p.M1921V	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	2584							DNA binding			ovary(5)|breast(1)	6						GGAGGGATCATTGTGTGGGAA	0.438000													32	58					0	0	0.012213	0	0
PDHA2	5161	broad.mit.edu	37	4	96762017	96762017	+	Missense_Mutation	SNP	A	T	T			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr4:96762017A>T	uc003htr.3	+	1	779	c.716A>T	c.(715-717)GAT>GTT	p.D239V		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	239					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	GCCAGCCCTGATTACTACAAG	0.423000													43	61					0	0	0.007835	0	0
PRDM5	11107	broad.mit.edu	37	4	121774626	121774626	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr4:121774626G>A	uc003idn.2	-	3	497	c.247C>T	c.(247-249)CGC>TGC	p.R83C	PRDM5_uc003ido.2_Missense_Mutation_p.R83C|PRDM5_uc010ine.2_Missense_Mutation_p.R83C|PRDM5_uc010inf.2_Missense_Mutation_p.R83C|PRDM5_uc003idp.1_Missense_Mutation_p.R83C	NM_018699	NP_061169	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	83	SET.				histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2						TGAACGAAGCGAAGCCAGTTG	0.468000													127	427					0	0	0.014410	0	0
FBXW7	55294	broad.mit.edu	37	4	153245393	153245393	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr4:153245393C>T	uc003ims.2	-	11	1947	c.1798G>A	c.(1798-1800)GAT>AAT	p.D600N	FBXW7_uc011cii.1_Missense_Mutation_p.D600N|FBXW7_uc003imt.2_Missense_Mutation_p.D600N|FBXW7_uc011cih.1_Missense_Mutation_p.D424N|FBXW7_uc003imq.2_Missense_Mutation_p.D520N|FBXW7_uc003imr.2_Missense_Mutation_p.D482N	NM_033632	NP_361014	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7 isoform	600	WD 6.				interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleolus|nucleoplasm|nucleoplasm|SCF ubiquitin ligase complex	protein binding|protein binding			haematopoietic_and_lymphoid_tissue(125)|large_intestine(99)|stomach(16)|lung(14)|endometrium(13)|ovary(9)|biliary_tract(8)|upper_aerodigestive_tract(5)|central_nervous_system(3)|kidney(3)|skin(3)|pancreas(3)|breast(2)|prostate(2)|cervix(1)|NS(1)|bone(1)	308	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				ACTGTAGAATCTGCATTCCCA	0.388000			Mis|N|D|F		colorectal|endometrial|T-ALL								41	13					0	0	0.006230	0	0
ACSL1	2180	broad.mit.edu	37	4	185687059	185687059	+	Missense_Mutation	SNP	C	A	A			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr4:185687059C>A	uc003iww.2	-	14	1639	c.1345G>T	c.(1345-1347)GCC>TCC	p.A449S	ACSL1_uc011ckm.1_Missense_Mutation_p.A278S|ACSL1_uc003iwt.1_Missense_Mutation_p.A449S|ACSL1_uc003iwu.1_Missense_Mutation_p.A449S|ACSL1_uc011ckn.1_Missense_Mutation_p.A415S|ACSL1_uc003iws.1_Missense_Mutation_p.A19S	NM_001995	NP_001986	P33121	ACSL1_HUMAN	acyl-CoA synthetase long-chain family member 1	449	Cytoplasmic (Potential).				digestion|fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|regulation of fatty acid oxidation|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|long-chain fatty acid-CoA ligase activity			ovary(2)	2		all_lung(41;7.57e-14)|Lung NSC(41;1.81e-13)|Colorectal(36;0.00172)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0315)|all_neural(102;0.107)|Medulloblastoma(177;0.146)		all cancers(43;1.33e-28)|Epithelial(43;5.3e-25)|OV - Ovarian serous cystadenocarcinoma(60;4.88e-11)|Colorectal(24;3.59e-06)|STAD - Stomach adenocarcinoma(60;2.72e-05)|GBM - Glioblastoma multiforme(59;2.83e-05)|BRCA - Breast invasive adenocarcinoma(30;7.66e-05)|COAD - Colon adenocarcinoma(29;0.000538)|LUSC - Lung squamous cell carcinoma(40;0.008)|READ - Rectum adenocarcinoma(43;0.0419)	Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	CAGCCCAGGGCTGCTCTGAGG	0.602000													4	49					0.00909568	0.00986279	0.009096	1	0
CKMT2	1160	broad.mit.edu	37	5	80547053	80547053	+	Silent	SNP	G	A	A			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr5:80547053G>A	uc003khc.3	+	3	344	c.102G>A	c.(100-102)CGG>CGA	p.R34R	RNU5E_uc011cto.1_Intron|CKMT2_uc010jaq.2_Silent_p.R34R|CKMT2_uc003khd.3_Silent_p.R34R|uc003khe.1_Intron|uc003khf.1_Intron|uc003khg.1_Intron	NM_001825	NP_001816	P17540	KCRS_HUMAN	sarcomeric mitochondrial creatine kinase	34					creatine metabolic process|muscle contraction	mitochondrial inner membrane	ATP binding|creatine kinase activity				0		Lung NSC(167;0.00475)|all_lung(232;0.00502)|Ovarian(174;0.0336)		OV - Ovarian serous cystadenocarcinoma(54;2.29e-44)|Epithelial(54;1.05e-38)|all cancers(79;4.15e-34)	Creatine(DB00148)	TGCTGAACCGGCAGAAAGTGT	0.478000													5	229					0	0	0.001984	0	0
PIP5K1P1	206426	broad.mit.edu	37	6	7988181	7988181	+	Missense_Mutation	SNP	A	C	C			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr6:7988181A>C	uc003mxx.3	+	1	1847	c.1412A>C	c.(1411-1413)TAC>TCC	p.Y471S	TXNDC5_uc003mxw.2_Intron	NR_027712				RecName: Full=Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha;          Short=PtdIns(4)P-5-kinase alpha;          Short=PIP5KIalpha;          EC=2.7.1.68; AltName: Full=Phosphatidylinositol-4-phosphate 5-kinase type I alpha; AltName: Full=68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha;												0						TGCATTACTTACCAGCCATTG	0.473000													14	31					0	0	0.007291	0	0
OPRM1	4988	broad.mit.edu	37	6	154567919	154567919	+	Nonstop_Mutation	SNP	G	C	C			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr6:154567919G>C	uc003qpt.1	+	4	1494	c.1257G>C	c.(1255-1257)TAG>TAC	p.*419Y	IPCEF1_uc003qpw.2_Intron|IPCEF1_uc003qpx.2_Intron|IPCEF1_uc010kjh.2_Intron	NM_001008503	NP_001008503	P35372	OPRM_HUMAN	opioid receptor, mu 1 isoform MOR-1O	419					behavior|negative regulation of cell proliferation|sensory perception	endoplasmic reticulum|Golgi apparatus|integral to plasma membrane	mu-opioid receptor activity|protein binding			ovary(1)	1		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;9.26e-11)|BRCA - Breast invasive adenocarcinoma(81;0.0154)	Alfentanil(DB00802)|Anileridine(DB00913)|Buprenorphine(DB00921)|Butorphanol(DB00611)|Codeine(DB00318)|Dezocine(DB01209)|Diphenoxylate(DB01081)|Fentanyl(DB00813)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Levallorphan(DB00504)|Levomethadyl Acetate(DB01227)|Levorphanol(DB00854)|Loperamide(DB00836)|Methadone(DB00333)|Methadyl Acetate(DB01433)|Morphine(DB00295)|Nalbuphine(DB00844)|Naloxone(DB01183)|Naltrexone(DB00704)|Oxycodone(DB00497)|Oxymorphone(DB01192)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Remifentanil(DB00899)|Sufentanil(DB00708)|Tramadol(DB00193)	TGAAGAGGTAGATAATGTATT	0.428000													29	36					0	0	0.007291	0	0
PAPOLB	56903	broad.mit.edu	37	7	4901303	4901303	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr7:4901303G>A	uc003snk.2	-	1	323	c.139C>T	c.(139-141)CTC>TTC	p.L47F	RADIL_uc003sng.1_Intron|RADIL_uc011jwd.1_Intron|RADIL_uc003snj.1_Intron	NM_020144	NP_064529	Q9NRJ5	PAPOB_HUMAN	poly(A) polymerase beta (testis specific)	46					mRNA processing|RNA polyadenylation|transcription, DNA-dependent	nucleus	ATP binding|metal ion binding|polynucleotide adenylyltransferase activity|RNA binding			ovary(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.089)|OV - Ovarian serous cystadenocarcinoma(56;2.06e-14)		AAGGGCCTGAGGGTTTCTATT	0.542000													6	21					0	0	0.001984	0	0
ZNF727	442319	broad.mit.edu	37	7	63538653	63538653	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr7:63538653C>T	uc011kdm.1	+	4	1405	c.1226C>T	c.(1225-1227)TCA>TTA	p.S409L		NM_001159522	NP_001152994	A8MUV8	ZN727_HUMAN	zinc finger protein 727	409	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACCTGCTCCTCAAACCTTATT	0.388000													5	7					0	0	0.000602	0	0
MLXIPL	51085	broad.mit.edu	37	7	73010041	73010041	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr7:73010041G>A	uc003tyn.1	-	15	2284	c.2236C>T	c.(2236-2238)CGT>TGT	p.R746C	MLXIPL_uc003tyj.1_Missense_Mutation_p.R125C|MLXIPL_uc003tyk.1_Missense_Mutation_p.R725C|MLXIPL_uc003tyl.1_Missense_Mutation_p.R744C|MLXIPL_uc003tym.1_Missense_Mutation_p.R727C|MLXIPL_uc003tyo.1_RNA|MLXIPL_uc003typ.1_Missense_Mutation_p.R652C	NM_032951	NP_116569	Q9NP71	WBS14_HUMAN	Williams Beuren syndrome chromosome region 14	746					anatomical structure morphogenesis|energy reserve metabolic process|glucose mediated signaling pathway|intracellular protein kinase cascade|negative regulation of cell cycle arrest|negative regulation of oxidative phosphorylation|negative regulation of peptidyl-serine phosphorylation|positive regulation of cell proliferation|positive regulation of fatty acid biosynthetic process|positive regulation of glycolysis|positive regulation of transcription from RNA polymerase II promoter|triglyceride homeostasis	cytosol|transcription factor complex	carbohydrate response element binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding			pancreas(1)	1		Lung NSC(55;0.0659)|all_lung(88;0.152)				TGGTCAAAACGCTGGTGTGTG	0.632000													3	19					0	0	0.004672	0	0
GTF2IRD1	9569	broad.mit.edu	37	7	74016720	74016720	+	Missense_Mutation	SNP	C	T	T			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr7:74016720C>T	uc003uaq.2	+	27	3233	c.2840C>T	c.(2839-2841)GCC>GTC	p.A947V	GTF2IRD1_uc010lbq.2_Missense_Mutation_p.A964V|GTF2IRD1_uc003uap.2_Missense_Mutation_p.A932V|GTF2IRD1_uc003uar.1_3'UTR	NM_016328	NP_057412	Q9UHL9	GT2D1_HUMAN	GTF2I repeat domain containing 1 isoform 1	947				Missing: Cytoplasmic localization.		nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(4)	4						GTGGACTATGCCGGCCTGAAC	0.468000													4	95					0	0	0.000602	0	0
COL1A2	1278	broad.mit.edu	37	7	94052321	94052321	+	Missense_Mutation	SNP	G	A	A	rs147655324		TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr7:94052321G>A	uc003ung.1	+	40	2927	c.2456G>A	c.(2455-2457)CGT>CAT	p.R819H	COL1A2_uc011kib.1_Intron|COL1A2_uc010lfi.1_Intron	NM_000089	NP_000080	P08123	CO1A2_HUMAN	alpha 2 type I collagen precursor	819			Missing (in OI2A).		axon guidance|blood vessel development|collagen fibril organization|leukocyte migration|odontogenesis|platelet activation|regulation of blood pressure|Rho protein signal transduction|skeletal system development|skin morphogenesis|transforming growth factor beta receptor signaling pathway	collagen type I|extracellular space|plasma membrane	extracellular matrix structural constituent|identical protein binding|platelet-derived growth factor binding|protein binding, bridging		COL1A2/PLAG1(3)	soft_tissue(3)|central_nervous_system(3)|ovary(2)|skin(1)	9	all_cancers(62;2.46e-09)|all_epithelial(64;2.7e-08)		STAD - Stomach adenocarcinoma(171;0.0031)		Collagenase(DB00048)	GAAGGGCTTCGTGGTCCTCGT	0.562000										HNSCC(75;0.22)			55	144					0	0	0.014410	0	0
BAIAP2L1	55971	broad.mit.edu	37	7	97946560	97946560	+	Missense_Mutation	SNP	C	T	T	rs151171453		TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr7:97946560C>T	uc003upj.2	-	6	720	c.457G>A	c.(457-459)GCA>ACA	p.A153T		NM_018842	NP_061330	Q9UHR4	BI2L1_HUMAN	BAI1-associated protein 2-like 1	153	Potential.|IMD.				filopodium assembly|positive regulation of actin cytoskeleton reorganization|positive regulation of actin filament polymerization|response to bacterium|signal transduction	cell junction|cytoskeleton|cytosol|nucleus	actin binding|cytoskeletal adaptor activity|proline-rich region binding|SH3 domain binding			ovary(1)	1	all_cancers(62;4.34e-10)|all_epithelial(64;5e-10)|Esophageal squamous(72;0.00918)|Lung NSC(181;0.0113)|all_lung(186;0.0126)		STAD - Stomach adenocarcinoma(171;0.215)			TATTTGAGTGCGTTTCGGCTT	0.348000													7	279					0	0	0.003080	0	0
EZH2	2146	broad.mit.edu	37	7	148515119	148515119	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr7:148515119G>A	uc003wfd.1	-	10	1241	c.1075C>T	c.(1075-1077)CCC>TCC	p.P359S	EZH2_uc011kug.1_Missense_Mutation_p.P350S|EZH2_uc003wfb.1_Missense_Mutation_p.P364S|EZH2_uc003wfc.1_Missense_Mutation_p.P320S|EZH2_uc011kuh.1_Missense_Mutation_p.P350S|EZH2_uc011kui.1_Missense_Mutation_p.P359S|EZH2_uc011kuj.1_RNA	NM_004456	NP_004447	Q15910	EZH2_HUMAN	enhancer of zeste 2 isoform a	359					negative regulation of retinoic acid receptor signaling pathway|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	ESC/E(Z) complex	DNA binding|histone-lysine N-methyltransferase activity|protein binding			haematopoietic_and_lymphoid_tissue(180)|skin(2)|large_intestine(1)	183	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00239)			CTGTTATTGGGAAGCCGTCCT	0.547000			Mis		DLBCL								40	86					0	0	0.006999	0	0
ZNF777	27153	broad.mit.edu	37	7	149129368	149129368	+	Silent	SNP	C	T	T			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr7:149129368C>T	uc003wfv.2	-	6	2158	c.1995G>A	c.(1993-1995)ACG>ACA	p.T665T		NM_015694	NP_056509	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	665	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			ACTCGGGGCACGTGTAGGGCC	0.612000													78	78					0	0	0.014410	0	0
CYP7B1	9420	broad.mit.edu	37	8	65509397	65509397	+	Silent	SNP	C	T	T			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr8:65509397C>T	uc003xvj.2	-	6	1527	c.1323G>A	c.(1321-1323)CCG>CCA	p.P441P		NM_004820	NP_004811	O75881	CP7B1_HUMAN	cytochrome P450, family 7, subfamily B,	441					bile acid biosynthetic process|cell death|cholesterol metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	25-hydroxycholesterol 7alpha-hydroxylase activity|electron carrier activity|heme binding|oxysterol 7-alpha-hydroxylase activity			ovary(3)	3		all_cancers(86;0.217)|Lung NSC(129;0.0521)|all_lung(136;0.0906)|all_epithelial(80;0.215)				CAGTTCCAAACGGCATTAGGT	0.333000													25	76					0	0	0.003330	0	0
SPAG1	6674	broad.mit.edu	37	8	101174635	101174635	+	Missense_Mutation	SNP	C	A	A			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr8:101174635C>A	uc003yjh.1	+	2	213	c.127C>A	c.(127-129)CTT>ATT	p.L43I	SPAG1_uc003yjg.1_Missense_Mutation_p.L43I|SPAG1_uc003yji.1_Missense_Mutation_p.L43I	NM_172218	NP_757367	Q07617	SPAG1_HUMAN	sperm associated antigen 1	43					single fertilization	cytoplasm	GTP binding|hydrolase activity			ovary(2)|central_nervous_system(1)	3	all_cancers(14;2.35e-05)|all_epithelial(15;5.2e-08)|Lung NSC(17;0.000283)|all_lung(17;0.000823)	Breast(495;0.195)	Epithelial(11;1.12e-09)|all cancers(13;1.26e-07)|OV - Ovarian serous cystadenocarcinoma(57;4.37e-05)|STAD - Stomach adenocarcinoma(118;0.0525)	KIRC - Kidney renal clear cell carcinoma(542;0.00178)|READ - Rectum adenocarcinoma(644;0.236)		GGAAAAAATTCTTTGCGTGCT	0.299000													20	37					1.56452e-12	1.78237e-12	0.007413	1	0
RHPN1	114822	broad.mit.edu	37	8	144463474	144463474	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr8:144463474G>A	uc003yyb.2	+	12	1581	c.1448G>A	c.(1447-1449)CGC>CAC	p.R483H		NM_052924	NP_443156	Q8TCX5	RHPN1_HUMAN	rhophilin 1	508					signal transduction	intracellular				large_intestine(1)	1	all_cancers(97;7.39e-11)|all_epithelial(106;5.44e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000459)|Ovarian(258;0.0212)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.107)|BRCA - Breast invasive adenocarcinoma(115;0.156)			AGGATGCCACGCCTGTCCCAG	0.627000													3	22					0	0	0.009096	0	0
KANK1	23189	broad.mit.edu	37	9	731209	731209	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr9:731209G>A	uc003zgl.1	+	9	3597	c.2948G>A	c.(2947-2949)GGT>GAT	p.G983D	KANK1_uc003zgm.2_3'UTR|KANK1_uc003zgn.1_Missense_Mutation_p.G983D|KANK1_uc003zgs.1_Missense_Mutation_p.G825D|KANK1_uc010mgx.1_5'Flank|KANK1_uc010mgy.1_5'Flank	NM_015158	NP_055973	Q14678	KANK1_HUMAN	KN motif and ankyrin repeat domains 1 isoform a	983					negative regulation of actin filament polymerization	cytoplasm				ovary(2)|central_nervous_system(1)|pancreas(1)	4		Lung NSC(10;9.84e-12)|all_lung(10;1.02e-11)|Breast(48;0.128)		Epithelial(6;0.000153)|OV - Ovarian serous cystadenocarcinoma(1;0.000358)|Lung(218;0.0222)		AAGAAAGATGGTAACAAAGAT	0.378000													16	34					0	0	0.007413	0	0
PTAR1	375743	broad.mit.edu	37	9	72365756	72365756	+	Missense_Mutation	SNP	G	C	C			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr9:72365756G>C	uc004ahj.3	-	2	219	c.197C>G	c.(196-198)CCA>CGA	p.P66R	PTAR1_uc004ahi.2_Intron	NM_001099666	NP_001093136	Q7Z6K3	PTAR1_HUMAN	protein prenyltransferase alpha subunit repeat	66					protein prenylation		protein prenyltransferase activity			central_nervous_system(1)	1						GTGGACATATGGTAAAAGGAA	0.428000													8	23					0	0	0.004482	0	0
SMC5	23137	broad.mit.edu	37	9	72929658	72929658	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr9:72929658G>A	uc004ahr.2	+	12	1696	c.1579G>A	c.(1579-1581)GTT>ATT	p.V527I		NM_015110	NP_055925	Q8IY18	SMC5_HUMAN	SMC5 protein	527	Flexible hinge.				DNA recombination|DNA repair	chromosome|nucleus	ATP binding			ovary(2)|central_nervous_system(1)	3						CTATATTCAGGTTCGTGACAA	0.318000													4	55					0	0	0.009096	0	0
PRUNE2	158471	broad.mit.edu	37	9	79465412	79465412	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr9:79465412G>A	uc010mpk.2	-	3	435	c.311C>T	c.(310-312)TCG>TTG	p.S104L	PRUNE2_uc004akn.2_Missense_Mutation_p.S104L	NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	104					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						AAGTGTTATCGATAACTTCCC	0.423000													73	52					0	0	0.014410	0	0
TMEM47	83604	broad.mit.edu	37	X	34657409	34657409	+	Nonsense_Mutation	SNP	G	A	A			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chrX:34657409G>A	uc004ddh.2	-	2	581	c.322C>T	c.(322-324)CGA>TGA	p.R108*	TMEM47_uc010ngs.2_RNA	NM_031442	NP_113630	Q9BQJ4	TMM47_HUMAN	transmembrane protein 47	108						integral to membrane				lung(1)	1						AAACGCCTTCGAGATCCCACG	0.448000													7	16					0	0	0.003080	0	0
ZC3H12B	340554	broad.mit.edu	37	X	64717050	64717050	+	Missense_Mutation	SNP	A	G	G			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chrX:64717050A>G	uc010nko.2	+	2	623	c.614A>G	c.(613-615)CAA>CGA	p.Q205R		NM_001010888	NP_001010888	Q5HYM0	ZC12B_HUMAN	zinc finger CCCH-type containing 12B	205							endonuclease activity|nucleic acid binding|zinc ion binding			lung(1)|kidney(1)|pancreas(1)	3						AGAGGAATACAACTTGCTGTG	0.388000													30	23					0	0	0.010818	0	0
FAM122B	159090	broad.mit.edu	37	X	133923280	133923280	+	Missense_Mutation	SNP	A	G	G			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chrX:133923280A>G	uc004exr.2	-	3	344	c.194T>C	c.(193-195)ATG>ACG	p.M65T	FAM122B_uc004exq.2_Missense_Mutation_p.M84T|FAM122B_uc004exs.2_Missense_Mutation_p.M65T|FAM122B_uc004ext.2_Missense_Mutation_p.M12T|FAM122B_uc004exu.2_RNA|FAM122B_uc011mvp.1_Missense_Mutation_p.M31T|FAM122B_uc004exv.2_Missense_Mutation_p.M84T	NM_145284	NP_660327	Q7Z309	F122B_HUMAN	hypothetical protein LOC159090	65											0	Acute lymphoblastic leukemia(192;0.000127)					TCTGTTCACCATATCCAGGCC	0.418000													4	146					0	0	0.000602	0	0
MAMLD1	10046	broad.mit.edu	37	X	149638349	149638349	+	Silent	SNP	C	T	T			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chrX:149638349C>T	uc004fee.1	+	3	580	c.504C>T	c.(502-504)AGC>AGT	p.S168S	MAMLD1_uc011mxt.1_Silent_p.S130S|MAMLD1_uc011mxu.1_Silent_p.S143S|MAMLD1_uc011mxv.1_Silent_p.S143S|MAMLD1_uc011mxw.1_Silent_p.S95S	NM_005491	NP_005482	Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	168					male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(192;6.56e-05)					AAATCAACAGCGTGCCGGCTG	0.478000													10	106					0	0	0.008291	0	0
FUNDC2	65991	broad.mit.edu	37	X	154261744	154261744	+	Missense_Mutation	SNP	G	A	A			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chrX:154261744G>A	uc004fmw.2	+	2	350	c.200G>A	c.(199-201)CGT>CAT	p.R67H		NM_023934	NP_076423	Q9BWH2	FUND2_HUMAN	FUN14 domain containing 2	67						mitochondrion					0	all_cancers(53;3.51e-17)|all_epithelial(53;5.13e-11)|all_lung(58;3.84e-07)|Lung NSC(58;1.2e-06)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					CCATGGTGGCGTAAGCTGTTC	0.438000													5	138					0	0	0.000602	0	0
PAX7	5081	broad.mit.edu	37	1	19071367	19071367	+	Frame_Shift_Del	DEL	G	-	-			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr1:19071367delG	uc010oct.1	+	9	2060	c.1462delG	c.(1462-1464)GGGfs	p.G488fs		NM_001135254	NP_001128726	P23759	PAX7_HUMAN	paired box 7 isoform 3	Error:Variant_position_missing_in_P23759_after_alignment					anti-apoptosis	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity		PAX7/FOXO1(197)	soft_tissue(197)|lung(3)|prostate(1)|ovary(1)|breast(1)	203		Colorectal(325;3.46e-05)|all_lung(284;0.000439)|Renal(390;0.000518)|Lung NSC(340;0.000543)|Breast(348;0.00093)|Ovarian(437;0.00768)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00609)|BRCA - Breast invasive adenocarcinoma(304;4.71e-05)|Kidney(64;0.000279)|KIRC - Kidney renal clear cell carcinoma(64;0.00371)|STAD - Stomach adenocarcinoma(196;0.00658)|READ - Rectum adenocarcinoma(331;0.0576)		CATGAAGCTCGGGGAGCACTC	0.567			T	FOXO1A	alveolar rhabdomyosarcoma								2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	1	94871896	94871896	+	IGR	DEL	G	-	-	rs12091363		TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr1:94871896delG								ARHGAP29 (131272 upstream) : ABCD3 (12037 downstream)																							aTTTTGTTTTGTTTTTTTTTT	0.184													7	2	---	---	---	---					
Unknown	0	broad.mit.edu	37	10	130262702	130262703	+	IGR	INS	-	A	A	rs66538679		TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr10:130262702_130262703insA								MKI67 (338234 upstream) : None (None downstream)																							cctcctcctccccatccttccc	0.040													2	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	13	49785470	49785471	+	IGR	INS	-	A	A			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr13:49785470_49785471insA								FNDC3A (1556 upstream) : MLNR (9003 downstream)																							aaaatgataataaaaaaaaaaa	0.213													5	2	---	---	---	---					
Unknown	0	broad.mit.edu	37	14	102989826	102989837	+	IGR	DEL	AGGGAGGAAGGA	-	-	rs11626505	by1000genomes	TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr14:102989826_102989837delAGGGAGGAAGGA								ANKRD9 (13698 upstream) : RCOR1 (69396 downstream)																							ggagggagggagggaggaaggaaggaaggaag	0.255													3	4	---	---	---	---					
Unknown	0	broad.mit.edu	37	15	78202278	78202278	+	IGR	DEL	C	-	-	rs71145877		TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr15:78202278delC								LINGO1 (213803 upstream) : LOC645752 (4281 downstream)																							TTGACAGTGGCTCCCCCAGCC	0.577													4	4	---	---	---	---					
MLL4	9757	broad.mit.edu	37	19	36224005	36224006	+	Frame_Shift_Ins	INS	-	C	C	rs147972814	by1000genomes	TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr19:36224005_36224006insC	uc010eei.2	+	29	6555_6556	c.6555_6556insC	c.(6553-6558)AAACCCfs	p.K2185fs		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	2185_2186					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AGCCCCCCAAACCCGCCACATC	0.629													3	5	---	---	---	---					
Unknown	0	broad.mit.edu	37	2	128824753	128824754	+	IGR	INS	-	A	A	rs113610724		TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr2:128824753_128824754insA								SAP130 (39120 upstream) : UGGT1 (24000 downstream)																							agactccatctaaaaaaaaaaa	0.173													2	4	---	---	---	---					
IFNGR2	3460	broad.mit.edu	37	21	34799292	34799292	+	Frame_Shift_Del	DEL	T	-	-			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr21:34799292delT	uc002yrp.3	+	4	1162	c.514delT	c.(514-516)TTTfs	p.F172fs	IFNGR2_uc002yrq.3_Frame_Shift_Del_p.F191fs|IFNGR2_uc010gma.2_Frame_Shift_Del_p.F93fs|IFNGR2_uc002yrr.3_Frame_Shift_Del_p.F93fs	NM_005534	NP_005525	P38484	INGR2_HUMAN	interferon gamma receptor 2 precursor	172	Extracellular (Potential).|Fibronectin type-III 2.				regulation of interferon-gamma-mediated signaling pathway|response to virus	endoplasmic reticulum|integral to plasma membrane	interferon-gamma receptor activity				0					Interferon gamma-1b(DB00033)	CTCCACGGCCTTTTTTTGTTA	0.458													10	483	---	---	---	---					
HIST1H2BL	8340	broad.mit.edu	37	6	27778338	27778339	+	5'Flank	DEL	TC	-	-			TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr6:27778338_27778339delTC	uc003njl.2	-							NM_003519	NP_003510	Q99880	H2B1L_HUMAN	histone cluster 1, H2bl						nucleosome assembly	nucleosome|nucleus	DNA binding				0						AAGATCTGTTTCTCTCAGGAAT	0.470													5	9	---	---	---	---					
MLL3	58508	broad.mit.edu	37	7	151873935	151873954	+	Frame_Shift_Del	DEL	GTCTTTTCTCCATCATTTAG	-	-	rs148752146		TCGA-C5-A1M9-01A-11D-A13W-08	TCGA-C5-A1M9-10A-01D-A13W-08									Somatic	Phase_I	Capture				Illumina GAIIx	70e4fbc8-094d-4493-8bf3-d28395d721e1	f3d88d4e-4ef1-496b-bc30-4566c3d4de72	g.chr7:151873935_151873954delGTCTTTTCTCCATCATTTAG	uc003wla.2	-	38	8803_8822	c.8584_8603delCTAAATGATGGAGAAAAGAC	c.(8584-8604)CTAAATGATGGAGAAAAGACTfs	p.L2862fs	MLL3_uc003wkz.2_Frame_Shift_Del_p.L1923fs|MLL3_uc003wky.2_Frame_Shift_Del_p.L371fs	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	2862_2868					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		ATGCAAAGAAGTCTTTTCTCCATCATTTAGGTCTGAGTGA	0.405			N		medulloblastoma								52	106	---	---	---	---					
