Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
NBPF1	55672	broad.mit.edu	37	1	16907249	16907249	+	Missense_Mutation	SNP	T	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr1:16907249T>C	uc009vos.1	-	16	2470	c.1582A>G	c.(1582-1584)ATT>GTT	p.I528V	NBPF1_uc009vot.1_Intron|NBPF1_uc001ayz.1_Intron|NBPF1_uc010oce.1_Missense_Mutation_p.I257V	NM_017940	NP_060410	Q3BBV0	NBPF1_HUMAN	hypothetical protein LOC55672	528	NBPF 2.					cytoplasm					0				UCEC - Uterine corpus endometrioid carcinoma (279;0.00459)|BRCA - Breast invasive adenocarcinoma(304;7.52e-06)|COAD - Colon adenocarcinoma(227;1.05e-05)|Kidney(64;0.00016)|KIRC - Kidney renal clear cell carcinoma(64;0.00258)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.179)		CCTGGGAGAATGTTTACAGCA	0.423000													14	649					0	0	0	0
IQCC	55721	broad.mit.edu	37	1	32673134	32673134	+	Silent	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr1:32673134G>A	uc001bum.2	+	5	899	c.852G>A	c.(850-852)CCG>CCA	p.P284P	IQCC_uc009vua.2_Silent_p.P364P|IQCC_uc010ogz.1_Silent_p.P184P|DCDC2B_uc001bun.2_5'Flank	NM_018134	NP_060604	Q4KMZ1	IQCC_HUMAN	IQ motif containing C isoform 2	284										ovary(4)	4		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				CTGGACCACCGTCGTCTATAC	0.537000													10	57					0	0	0	0
OSCP1	127700	broad.mit.edu	37	1	36909632	36909632	+	Missense_Mutation	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr1:36909632C>T	uc001cap.2	-	2	197	c.115G>A	c.(115-117)GAA>AAA	p.E39K	OSCP1_uc001caq.2_Intron|OSCP1_uc001car.2_Intron	NM_145047	NP_659484	Q8WVF1	OSCP1_HUMAN	oxidored-nitro domain-containing protein isoform	39					transport	basal plasma membrane				ovary(2)|central_nervous_system(1)|pancreas(1)	4						TCTGTCCATTCATCTACATGA	0.418000													10	129					0	0	0	0
GLIS1	148979	broad.mit.edu	37	1	54060498	54060498	+	Silent	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr1:54060498G>A	uc001cvr.1	-	3	645	c.78C>T	c.(76-78)CTC>CTT	p.L26L		NM_147193	NP_671726	Q8NBF1	GLIS1_HUMAN	GLIS family zinc finger 1	26					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			skin(1)	1						TTCGGCCCGGGAGGTCCAGGT	0.706000													3	11					0	0	0	0
LRIG2	9860	broad.mit.edu	37	1	113657399	113657399	+	Missense_Mutation	SNP	A	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr1:113657399A>G	uc001edf.1	+	15	2629	c.2431A>G	c.(2431-2433)ATT>GTT	p.I811V	LRIG2_uc009wgn.1_Missense_Mutation_p.I708V	NM_014813	NP_055628	O94898	LRIG2_HUMAN	leucine-rich repeats and immunoglobulin-like	811	Helical; (Potential).					cytoplasm|integral to membrane|plasma membrane				ovary(3)	3	Lung SC(450;0.246)	all_cancers(81;1.56e-05)|all_epithelial(167;2.62e-05)|all_lung(203;0.000665)|Lung NSC(69;0.000986)		Lung(183;0.0279)|Colorectal(144;0.0885)|COAD - Colon adenocarcinoma(174;0.134)|all cancers(265;0.139)|Epithelial(280;0.143)|LUSC - Lung squamous cell carcinoma(189;0.15)		CATTGTCATCATTGTTGTGGT	0.423000													14	95					0	0	0	0
TTF2	8458	broad.mit.edu	37	1	117644143	117644143	+	Silent	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr1:117644143C>T	uc001egy.2	+	23	3506	c.3486C>T	c.(3484-3486)ATC>ATT	p.I1162I		NM_003594	NP_003585	Q9UNY4	TTF2_HUMAN	transcription termination factor, RNA polymerase	1162					mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|termination of RNA polymerase II transcription	cytoplasm|spliceosomal complex|transcription elongation factor complex	ATP binding|ATP-dependent helicase activity|DNA binding|DNA-dependent ATPase activity|protein binding|zinc ion binding			ovary(1)	1	Lung SC(450;0.225)	all_cancers(81;4.23e-06)|all_epithelial(167;3.65e-07)|all_lung(203;2.81e-06)|Lung NSC(69;1.98e-05)		Lung(183;0.0553)|Colorectal(144;0.179)|LUSC - Lung squamous cell carcinoma(189;0.19)		TTTTTGGCATCTAACCTCCTG	0.443000													22	201					0	0	0	0
HIST2H2BF	440689	broad.mit.edu	37	1	149783657	149783657	+	Missense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr1:149783657G>C	uc001esr.2	-	1	272	c.222C>G	c.(220-222)ATC>ATG	p.I74M	HIST2H2BF_uc010pbj.1_Missense_Mutation_p.I74M|HIST2H2BF_uc010pbk.1_Missense_Mutation_p.I74M	NM_001024599	NP_001019770	Q5QNW6	H2B2F_HUMAN	histone cluster 2, H2bf isoform a	74					nucleosome assembly	nucleosome|nucleus	DNA binding				0	Breast(34;0.0124)|all_hematologic(923;0.127)					CCTCTCCCGCGATGCGCTCGA	0.642000													6	124					0	0	0	0
ANXA9	8416	broad.mit.edu	37	1	150956843	150956843	+	Silent	SNP	C	T	T	rs150030788		TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr1:150956843C>T	uc001ewa.2	+	6	824	c.354C>T	c.(352-354)GAC>GAT	p.D118D		NM_003568	NP_003559	O76027	ANXA9_HUMAN	annexin A9	118	Annexin 2.				cell-cell adhesion	cell surface|cytosol	acetylcholine receptor activity|calcium ion binding|calcium-dependent phospholipid binding|phosphatidylserine binding|protein homodimerization activity				0	all_lung(15;1.09e-34)|Lung NSC(24;1.1e-30)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			CCCAGTTTGACGCCCAGGAAT	0.552000													8	115					0	0	0	0
SH2D2A	9047	broad.mit.edu	37	1	156779022	156779022	+	Silent	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr1:156779022G>A	uc001fqd.2	-	7	1115	c.975C>T	c.(973-975)AGC>AGT	p.S325S	SH2D2A_uc001fqc.1_Silent_p.S297S|SH2D2A_uc009wsh.2_Silent_p.S335S|SH2D2A_uc001fqe.2_Silent_p.S307S|SH2D2A_uc010phs.1_Silent_p.S325S	NM_003975	NP_003966	Q9NP31	SH22A_HUMAN	SH2 domain protein 2A isoform 2	325	Pro-rich.				angiogenesis|cell differentiation|signal transduction	cytoplasm|soluble fraction	SH3 domain binding|SH3/SH2 adaptor activity				0	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GCCTGGACCAGCTCTTCCGTA	0.612000													17	226					0	0	0	0
OR2T6	254879	broad.mit.edu	37	1	248551279	248551279	+	Missense_Mutation	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr1:248551279G>A	uc001iei.1	+	1	370	c.370G>A	c.(370-372)GTG>ATG	p.V124M		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	124	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGACCGCTACGTGGCCATCTG	0.567000													10	68					0	0	0	0
CACNB2	783	broad.mit.edu	37	10	18827254	18827254	+	Nonsense_Mutation	SNP	C	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr10:18827254C>G	uc001ipr.2	+	13	1508	c.1448C>G	c.(1447-1449)TCA>TGA	p.S483*	CACNB2_uc009xjz.1_Nonsense_Mutation_p.S233*|CACNB2_uc001ips.2_Nonsense_Mutation_p.S459*|CACNB2_uc001ipt.2_Nonsense_Mutation_p.S445*|CACNB2_uc001ipu.2_Nonsense_Mutation_p.S455*|CACNB2_uc001ipv.2_Nonsense_Mutation_p.S431*|CACNB2_uc009xka.1_Nonsense_Mutation_p.S417*|CACNB2_uc001ipw.2_Nonsense_Mutation_p.S390*|CACNB2_uc001ipx.2_Nonsense_Mutation_p.S428*|CACNB2_uc001ipz.2_Nonsense_Mutation_p.S405*|CACNB2_uc001ipy.2_Nonsense_Mutation_p.S429*|CACNB2_uc010qco.1_Nonsense_Mutation_p.S397*|CACNB2_uc001iqa.2_Nonsense_Mutation_p.S435*|NSUN6_uc001iqb.2_Intron	NM_201596	NP_963890	Q08289	CACB2_HUMAN	calcium channel, voltage-dependent, beta 2	483					axon guidance|neuromuscular junction development	integral to plasma membrane|sarcolemma|voltage-gated calcium channel complex	protein binding|voltage-gated calcium channel activity			large_intestine(1)|central_nervous_system(1)|skin(1)	3					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	TTAGCCACTTCAAGTCTGCCT	0.478000													9	266					0	0	0	0
GPR158	57512	broad.mit.edu	37	10	25887142	25887142	+	Missense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr10:25887142G>C	uc001isj.2	+	11	2647	c.2587G>C	c.(2587-2589)GAA>CAA	p.E863Q	GPR158_uc001isk.2_Missense_Mutation_p.E238Q	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	863	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						AAAACTAAAAGAAGACAGCGA	0.507000													5	144					0	0	0	0
C10orf50	645528	broad.mit.edu	37	10	26880266	26880266	+	RNA	SNP	G	A	A	rs138111133	by1000genomes	TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr10:26880266G>A	uc001ist.2	+	2		c.501G>A				NR_026793				Homo sapiens, clone IMAGE:5172288, mRNA.												0						ACCAAGCCCAGTGGACAGATG	0.443000													5	34					0	0	0	0
ARMC4	55130	broad.mit.edu	37	10	28229719	28229719	+	Missense_Mutation	SNP	A	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr10:28229719A>T	uc009xky.2	-	13	1857	c.1759T>A	c.(1759-1761)TGT>AGT	p.C587S	ARMC4_uc010qds.1_Missense_Mutation_p.C112S|ARMC4_uc010qdt.1_Missense_Mutation_p.C279S|ARMC4_uc001itz.2_Missense_Mutation_p.C587S|ARMC4_uc010qdu.1_Missense_Mutation_p.C279S	NM_018076	NP_060546	Q5T2S8	ARMC4_HUMAN	armadillo repeat containing 4	587							binding			ovary(4)|skin(2)	6						TCATGTGCACAGTCTAGTAGA	0.443000													6	66					0	0	0	0
NRP1	8829	broad.mit.edu	37	10	33502550	33502550	+	Missense_Mutation	SNP	C	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr10:33502550C>G	uc001iwx.3	-	9	1901	c.1378G>C	c.(1378-1380)GAA>CAA	p.E460Q	NRP1_uc001iwv.3_Missense_Mutation_p.E460Q|NRP1_uc009xlz.2_Missense_Mutation_p.E460Q|NRP1_uc001iww.3_Missense_Mutation_p.E279Q|NRP1_uc001iwy.3_Missense_Mutation_p.E460Q|NRP1_uc001iwz.2_Missense_Mutation_p.E460Q|NRP1_uc001ixa.2_Missense_Mutation_p.E460Q|NRP1_uc001ixb.1_Missense_Mutation_p.E460Q|NRP1_uc001ixc.1_Missense_Mutation_p.E460Q	NM_003873	NP_003864	O14786	NRP1_HUMAN	neuropilin 1 isoform a	460	Extracellular (Potential).|F5/8 type C 2.				axon guidance|cell adhesion|cell-cell signaling|organ morphogenesis|positive regulation of cell proliferation	extracellular region|integral to membrane|plasma membrane	growth factor binding|heparin binding|metal ion binding|vascular endothelial growth factor receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4					Palifermin(DB00039)|Pegaptanib(DB04895)	CGGATGTTTTCAGGCATCCAG	0.517000													11	136					0	0	0	0
RHOBTB1	9886	broad.mit.edu	37	10	62631978	62631978	+	Missense_Mutation	SNP	G	C	C	rs148172627		TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr10:62631978G>C	uc001jli.2	-	11	2324	c.1886C>G	c.(1885-1887)TCC>TGC	p.S629C	RHOBTB1_uc001jlh.2_Missense_Mutation_p.S629C|RHOBTB1_uc001jlj.2_Missense_Mutation_p.S629C|RHOBTB1_uc001jlk.2_Missense_Mutation_p.S629C|RHOBTB1_uc009xpe.1_Missense_Mutation_p.S567C|RHOBTB1_uc009xpd.2_Intron|RHOBTB1_uc001jll.2_Missense_Mutation_p.S379C	NM_014836	NP_055651	O94844	RHBT1_HUMAN	Rho-related BTB domain containing 1	629					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			upper_aerodigestive_tract(1)	1	Prostate(12;0.0112)					ACGGAACTTGGAGCATACACT	0.483000													5	115					0	0	0	0
RUFY2	55680	broad.mit.edu	37	10	70156542	70156542	+	Silent	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr10:70156542G>A	uc001job.2	-	4	825	c.498C>T	c.(496-498)CTC>CTT	p.L166L	RUFY2_uc001jnz.1_RNA|RUFY2_uc001joc.2_Intron|RUFY2_uc010qiw.1_Silent_p.L73L|RUFY2_uc001jod.1_Silent_p.L131L|RUFY2_uc009xpv.1_Silent_p.L14L|RUFY2_uc001joe.1_Silent_p.L131L	NM_017987	NP_060457	Q8WXA3	RUFY2_HUMAN	RUN and FYVE domain-containing 2 isoform a	180	RUN.					nucleus	metal ion binding			ovary(1)	1						CTAACCTCAAGAGATCCCTCT	0.353000													6	41					0	0	0	0
VCL	7414	broad.mit.edu	37	10	75855416	75855416	+	Missense_Mutation	SNP	C	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr10:75855416C>G	uc001jwd.2	+	12	1640	c.1546C>G	c.(1546-1548)CAG>GAG	p.Q516E	VCL_uc009xrr.2_Missense_Mutation_p.Q265E|VCL_uc010qky.1_Missense_Mutation_p.Q423E|VCL_uc001jwe.2_Missense_Mutation_p.Q516E|VCL_uc010qkz.1_Intron	NM_014000	NP_054706	P18206	VINC_HUMAN	vinculin isoform meta-VCL	516	N-terminal globular head.|3.|3 X 112 AA tandem repeats.				adherens junction assembly|apical junction assembly|cell-matrix adhesion|cellular component movement|epithelial cell-cell adhesion|lamellipodium assembly|morphogenesis of an epithelium|muscle contraction|negative regulation of cell migration|platelet activation|platelet degranulation|protein localization at cell surface	costamere|cytosol|extracellular region|focal adhesion	actin binding|alpha-catenin binding|beta-catenin binding|beta-dystroglycan binding|cadherin binding|structural molecule activity		VCL/ALK(4)	kidney(4)|ovary(1)|central_nervous_system(1)	6	Prostate(51;0.0112)					TGGTCCAGGTCAGGCTGCCAT	0.478000													4	88					0	0	0	0
LGI1	9211	broad.mit.edu	37	10	95556810	95556810	+	Missense_Mutation	SNP	C	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr10:95556810C>G	uc001kjc.3	+	8	1260	c.924C>G	c.(922-924)ATC>ATG	p.I308M	LGI1_uc010qnv.1_Missense_Mutation_p.I260M|LGI1_uc001kjd.3_Intron|LGI1_uc009xui.2_RNA|LGI1_uc001kje.2_Intron	NM_005097	NP_005088	O95970	LGI1_HUMAN	leucine-rich, glioma inactivated 1 precursor	308	EAR 2.				axon guidance|cell proliferation|positive regulation of cell growth|positive regulation of synaptic transmission	cell junction|extracellular space|synapse	receptor binding			ovary(2)|central_nervous_system(1)|skin(1)	4		Colorectal(252;0.124)				GCTCTCACATCTATAAGCGAG	0.373000													4	77					0	0	0	0
PDCD11	22984	broad.mit.edu	37	10	105203734	105203734	+	Missense_Mutation	SNP	C	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr10:105203734C>G	uc001kwy.1	+	34	5274	c.5187C>G	c.(5185-5187)ATC>ATG	p.I1729M		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	1729	HAT 2.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		CTGTGTGGATCAAATACGGCG	0.597000													9	94					0	0	0	0
ACSL5	51703	broad.mit.edu	37	10	114169340	114169340	+	Missense_Mutation	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr10:114169340C>T	uc001kzs.2	+	7	749	c.608C>T	c.(607-609)ACC>ATC	p.T203I	ACSL5_uc001kzt.2_Missense_Mutation_p.T203I|ACSL5_uc001kzu.2_Missense_Mutation_p.T259I|ACSL5_uc009xxz.2_Missense_Mutation_p.T203I|ACSL5_uc010qrj.1_5'UTR	NM_203379	NP_976313	Q9ULC5	ACSL5_HUMAN	acyl-CoA synthetase long-chain family member 5	203	Cytoplasmic (Potential).				fatty acid metabolic process|long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|mitochondrial outer membrane	ATP binding|long-chain fatty acid-CoA ligase activity			large_intestine(2)|skin(1)	3		Colorectal(252;0.117)|Breast(234;0.222)		Epithelial(162;0.0343)|all cancers(201;0.137)		AAAGGCTTCACCCCGAGCCTG	0.478000													16	118					0	0	0	0
PRLHR	2834	broad.mit.edu	37	10	120353832	120353832	+	Missense_Mutation	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr10:120353832C>T	uc001ldp.1	-	2	1064	c.925G>A	c.(925-927)GAC>AAC	p.D309N		NM_004248	NP_004239	P49683	PRLHR_HUMAN	G protein-coupled receptor 10	309	Extracellular (Potential).				female pregnancy	integral to plasma membrane	neuropeptide Y receptor activity				0		Colorectal(252;0.0429)|Lung NSC(174;0.142)|all_lung(145;0.175)		all cancers(201;0.0166)		GCGTAAGGGTCGATGGCGTGG	0.632000													5	69					0	0	0	0
GRK5	2869	broad.mit.edu	37	10	121207689	121207689	+	Missense_Mutation	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr10:121207689G>A	uc001led.2	+	13	1554	c.1321G>A	c.(1321-1323)GAG>AAG	p.E441K	GRK5_uc009xzh.2_Missense_Mutation_p.E306K	NM_005308	NP_005299	P34947	GRK5_HUMAN	G protein-coupled receptor kinase 5	441	Protein kinase.				G-protein signaling, coupled to cAMP nucleotide second messenger|regulation of G-protein coupled receptor protein signaling pathway|tachykinin receptor signaling pathway	cytoplasm|plasma membrane|soluble fraction	ATP binding|G-protein coupled receptor kinase activity|phospholipid binding|protein kinase C binding|signal transducer activity			lung(2)|stomach(1)	3		Lung NSC(174;0.0971)|all_lung(145;0.127)|Ovarian(717;0.249)		all cancers(201;0.0227)		GGGGGCTGCAGAGGTCAAGAG	0.597000													21	116					0	0	0	0
OR51G2	81282	broad.mit.edu	37	11	4936270	4936270	+	Silent	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr11:4936270G>A	uc001lzr.1	-	1	624	c.624C>T	c.(622-624)ATC>ATT	p.I208I		NM_001005238	NP_001005238	Q8NGK0	O51G2_HUMAN	olfactory receptor, family 51, subfamily G,	208	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;5.06e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00438)|LUSC - Lung squamous cell carcinoma(625;0.19)		CTGTAGAGACGATGACAAACA	0.512000													4	33					0	0	0	0
CYP2R1	120227	broad.mit.edu	37	11	14899669	14899669	+	Nonstop_Mutation	SNP	C	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr11:14899669C>A	uc001mlr.2	-	5	1505	c.1505G>T	c.(1504-1506)TGA>TTA	p.*502L	CYP2R1_uc001mlo.2_Nonstop_Mutation_p.*269L|CYP2R1_uc001mlp.2_Nonstop_Mutation_p.*385L|CYP2R1_uc001mlq.2_RNA	NM_024514	NP_078790	Q6VVX0	CP2R1_HUMAN	cytochrome P450, family 2, subfamily R,	502					hormone biosynthetic process|vitamin D metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding|vitamin D3 25-hydroxylase activity			ovary(1)|central_nervous_system(1)	2					Cholecalciferol(DB00169)|Ergocalciferol(DB00153)	CAGGCAGTTTCAGCGTCTTTC	0.418000													9	89					0.000442599	0.00205539	1	0
CYP2R1	120227	broad.mit.edu	37	11	14900748	14900748	+	Missense_Mutation	SNP	C	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr11:14900748C>A	uc001mlr.2	-	4	1242	c.1242G>T	c.(1240-1242)TGG>TGT	p.W414C	CYP2R1_uc001mlo.2_Missense_Mutation_p.W181C|CYP2R1_uc001mlp.2_Missense_Mutation_p.W297C|CYP2R1_uc001mlq.2_RNA	NM_024514	NP_078790	Q6VVX0	CP2R1_HUMAN	cytochrome P450, family 2, subfamily R,	414					hormone biosynthetic process|vitamin D metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	cholestanetriol 26-monooxygenase activity|electron carrier activity|heme binding|vitamin D3 25-hydroxylase activity			ovary(1)|central_nervous_system(1)	2					Cholecalciferol(DB00169)|Ergocalciferol(DB00153)	CTGGGTCTCTCCAGTACTTTT	0.408000													5	53					0.000602214	0.00278305	1	0
OR5AR1	219493	broad.mit.edu	37	11	56431616	56431616	+	Missense_Mutation	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr11:56431616G>A	uc010rjm.1	+	1	455	c.455G>A	c.(454-456)GGT>GAT	p.G152D		NM_001004730	NP_001004730	Q8NGP9	O5AR1_HUMAN	olfactory receptor, family 5, subfamily AR,	152	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TACCTGGCTGGTCTAGTGAGT	0.502000													13	161					0	0	0	0
CTNND1	1500	broad.mit.edu	37	11	57578934	57578934	+	Missense_Mutation	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr11:57578934C>T	uc001nmc.3	+	17	3185	c.2614C>T	c.(2614-2616)CTC>TTC	p.L872F	CTNND1_uc001nlh.1_Missense_Mutation_p.L872F|CTNND1_uc001nlu.3_Missense_Mutation_p.L765F|CTNND1_uc001nlt.3_Missense_Mutation_p.L765F|CTNND1_uc001nls.3_Missense_Mutation_p.L765F|CTNND1_uc001nlw.3_Missense_Mutation_p.L765F|CTNND1_uc001nmf.3_Missense_Mutation_p.L872F|CTNND1_uc001nmd.3_Missense_Mutation_p.L818F|CTNND1_uc001nlk.3_Missense_Mutation_p.L818F|CTNND1_uc001nme.3_Missense_Mutation_p.L866F|CTNND1_uc001nll.3_Missense_Mutation_p.L812F|CTNND1_uc001nmg.3_Missense_Mutation_p.L812F|CTNND1_uc001nlj.3_Missense_Mutation_p.L812F|CTNND1_uc001nlr.3_Missense_Mutation_p.L812F|CTNND1_uc001nlp.3_Missense_Mutation_p.L812F|CTNND1_uc001nlx.3_Missense_Mutation_p.L549F|CTNND1_uc001nlz.3_Missense_Mutation_p.L549F|CTNND1_uc009ymn.2_Missense_Mutation_p.L543F|CTNND1_uc001nlm.3_Missense_Mutation_p.L866F|CTNND1_uc001nly.3_Missense_Mutation_p.L543F|CTNND1_uc001nmb.3_Missense_Mutation_p.L543F|CTNND1_uc001nma.3_Missense_Mutation_p.L543F|CTNND1_uc001nmi.3_Missense_Mutation_p.L771F|CTNND1_uc001nmh.3_Missense_Mutation_p.L866F|CTNND1_uc001nlq.3_Missense_Mutation_p.L771F|CTNND1_uc001nln.3_Missense_Mutation_p.L866F|CTNND1_uc001nli.3_Missense_Mutation_p.L866F|CTNND1_uc001nlo.3_Missense_Mutation_p.L765F|CTNND1_uc001nlv.3_Missense_Mutation_p.L765F	NM_001085458	NP_001078927	O60716	CTND1_HUMAN	catenin, delta 1 isoform 1ABC	872					adherens junction organization|cell junction assembly|negative regulation of canonical Wnt receptor signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent|Wnt receptor signaling pathway	cytosol|midbody|nucleus	cadherin binding|protein binding|receptor binding			breast(4)|ovary(1)|kidney(1)	6		all_epithelial(135;0.155)				TACTCTCCCTCTCATTGACCG	0.438000													8	158					0	0	0	0
C11orf9	745	broad.mit.edu	37	11	61551813	61551813	+	Missense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr11:61551813G>C	uc001nsc.1	+	25	3352	c.3256G>C	c.(3256-3258)GAG>CAG	p.E1086Q	C11orf9_uc001nse.1_Missense_Mutation_p.E1046Q|C11orf9_uc010rll.1_Missense_Mutation_p.E472Q	NM_001127392	NP_001120864	Q9Y2G1	MRF_HUMAN	myelin gene regulatory factor isoform 2	1086					central nervous system myelination|positive regulation of myelination|positive regulation of transcription, DNA-dependent	integral to membrane|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)	1						ACCATGTGAGGAGGGGAGCCT	0.622000													4	50					0	0	0	0
CD248	57124	broad.mit.edu	37	11	66083138	66083138	+	Missense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr11:66083138G>C	uc001ohm.1	-	1	1378	c.1361C>G	c.(1360-1362)TCT>TGT	p.S454C		NM_020404	NP_065137	Q9HCU0	CD248_HUMAN	tumor endothelial marker 1 precursor	454	Pro-rich.|Extracellular (Potential).					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			large_intestine(3)	3					Cefalotin(DB00456)	ATGCGTGGCAGAGACCACCAC	0.667000													7	106					0	0	0	0
RSF1	51773	broad.mit.edu	37	11	77412118	77412118	+	Missense_Mutation	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr11:77412118G>A	uc001oyn.2	-	6	2276	c.2156C>T	c.(2155-2157)TCA>TTA	p.S719L	RSF1_uc001oym.2_Missense_Mutation_p.S467L	NM_016578	NP_057662	Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	719					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			TGTATTTTCTGAGGCAGTGGT	0.428000													6	110					0	0	0	0
RSF1	51773	broad.mit.edu	37	11	77412372	77412372	+	Missense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr11:77412372G>C	uc001oyn.2	-	6	2022	c.1902C>G	c.(1900-1902)ATC>ATG	p.I634M	RSF1_uc001oym.2_Missense_Mutation_p.I382M	NM_016578	NP_057662	Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	634					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			AGTGGTCAATGATATTAGATG	0.428000													8	106					0	0	0	0
MMP12	4321	broad.mit.edu	37	11	102734890	102734890	+	Missense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr11:102734890G>C	uc001phk.2	-	10	1344	c.1299C>G	c.(1297-1299)TTC>TTG	p.F433L		NM_002426	NP_002417	P39900	MMP12_HUMAN	matrix metalloproteinase 12 preproprotein	433	Hemopexin-like 4.				positive regulation of epithelial cell proliferation involved in wound healing|proteolysis|wound healing, spreading of epidermal cells	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0		all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)		BRCA - Breast invasive adenocarcinoma(274;0.014)	Acetohydroxamic Acid(DB00551)	TTTTAGAGTAGAAGACTGCAT	0.383000													3	38					0	0	0	0
MLL	4297	broad.mit.edu	37	11	118374023	118374023	+	Missense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr11:118374023G>C	uc001pta.2	+	27	7430	c.7407G>C	c.(7405-7407)TTG>TTC	p.L2469F	MLL_uc001ptb.2_Missense_Mutation_p.L2472F	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	2469					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		ATGAGGTTTTGACTCCTGAGT	0.433000			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								5	68					0	0	0	0
MLL	4297	broad.mit.edu	37	11	118374030	118374030	+	Missense_Mutation	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr11:118374030G>A	uc001pta.2	+	27	7437	c.7414G>A	c.(7414-7416)GAG>AAG	p.E2472K	MLL_uc001ptb.2_Missense_Mutation_p.E2475K	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	2472					apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		TTTGACTCCTGAGTATATGGG	0.438000			T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								5	67					0	0	0	0
OR8G2	26492	broad.mit.edu	37	11	124095773	124095773	+	Missense_Mutation	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr11:124095773C>T	uc010saf.1	+	1	376	c.376C>T	c.(376-378)CAC>TAC	p.H126Y		NM_001007249	NP_001007250	Q15614	OR8G2_HUMAN	olfactory receptor, family 8, subfamily G,	126						integral to membrane	olfactory receptor activity				0		Breast(109;0.0157)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.91e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0528)		TGCAGAGTGTCACATGTTGGC	0.458000													18	198					0	0	0	0
SLCO1C1	53919	broad.mit.edu	37	12	20876121	20876121	+	Silent	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr12:20876121G>A	uc001rej.3	+	10	1474	c.1119G>A	c.(1117-1119)GTG>GTA	p.V373V	SLCO1C1_uc010sii.1_Silent_p.V373V|SLCO1C1_uc010sij.1_Silent_p.V324V|SLCO1C1_uc009zip.2_Silent_p.V207V|SLCO1C1_uc001rei.2_Silent_p.V373V|SLCO1C1_uc010sik.1_Silent_p.V255V	NM_017435	NP_059131	Q9NYB5	SO1C1_HUMAN	solute carrier organic anion transporter family,	373	Extracellular (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	thyroid hormone transmembrane transporter activity			ovary(5)|pancreas(1)|skin(1)	7	Esophageal squamous(101;0.149)					TCGGCATGGTGACGTACAAAC	0.423000													7	81					0	0	0	0
C12orf35	55196	broad.mit.edu	37	12	32135621	32135621	+	Missense_Mutation	SNP	C	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr12:32135621C>G	uc001rks.2	+	4	2146	c.1732C>G	c.(1732-1734)CAA>GAA	p.Q578E		NM_018169	NP_060639	Q9HCM1	CL035_HUMAN	hypothetical protein LOC55196	578										ovary(1)|skin(1)	2	all_cancers(9;3.36e-11)|all_epithelial(9;2.56e-11)|all_lung(12;5.67e-10)|Acute lymphoblastic leukemia(23;0.0122)|Lung SC(12;0.0336)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.204)		OV - Ovarian serous cystadenocarcinoma(6;0.0114)			ATCAAAAATTCAAAATGAAAA	0.348000													5	31					0	0	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54910753	54910753	+	Missense_Mutation	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr12:54910753G>A	uc001sgc.3	+	11	1151	c.1072G>A	c.(1072-1074)GAA>AAA	p.E358K	NCKAP1L_uc010sox.1_5'UTR|NCKAP1L_uc010soy.1_Missense_Mutation_p.E308K	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	358					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						GTTGGCTGATGAACCGGGACT	0.507000													9	88					0	0	0	0
TRHDE	29953	broad.mit.edu	37	12	72667122	72667122	+	Silent	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr12:72667122G>A	uc001sxa.2	+	1	594	c.564G>A	c.(562-564)GCG>GCA	p.A188A	LOC283392_uc010stv.1_5'UTR	NM_013381	NP_037513	Q9UKU6	TRHDE_HUMAN	thyrotropin-releasing hormone degrading enzyme	188	Extracellular (Potential).				cell-cell signaling|proteolysis|signal transduction	integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(2)|skin(1)	3						CCCGAGTGGCGGTGGAGAAAG	0.627000													10	65					0	0	0	0
SLC5A8	160728	broad.mit.edu	37	12	101555757	101555757	+	Missense_Mutation	SNP	G	A	A	rs142965122		TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr12:101555757G>A	uc001thz.3	-	13	2015	c.1625C>T	c.(1624-1626)TCA>TTA	p.S542L		NM_145913	NP_666018	Q8N695	SC5A8_HUMAN	solute carrier family 5 (iodide transporter),	542	Cytoplasmic (Potential).				apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity				0						GTTACCTGTTGATAAACTGAC	0.313000													6	178					0	0	0	0
ASCL1	429	broad.mit.edu	37	12	103352547	103352547	+	Silent	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr12:103352547C>T	uc001tjr.3	+	1	1096	c.525C>T	c.(523-525)GAC>GAT	p.D175D		NM_004316	NP_004307	P50553	ASCL1_HUMAN	achaete-scute complex homolog 1	175					cerebral cortex GABAergic interneuron differentiation|negative regulation of apoptosis|negative regulation of neuron differentiation|negative regulation of transcription, DNA-dependent|noradrenergic neuron fate commitment|Notch signaling pathway|positive regulation of neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|response to retinoic acid|sympathetic nervous system development	nucleus	bHLH transcription factor binding|E-box binding|sequence-specific DNA binding transcription factor activity|transcription factor binding transcription factor activity				0						AGCTGCTGGACGAGCATGACG	0.662000													11	45					0	0	0	0
GCN1L1	10985	broad.mit.edu	37	12	120572483	120572483	+	Silent	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr12:120572483G>A	uc001txo.2	-	52	7069	c.7056C>T	c.(7054-7056)TTC>TTT	p.F2352F		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	2352	HEAT 21.				regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGGCTTTGGTGAAAGTGGTCT	0.582000													8	69					0	0	0	0
ACADS	35	broad.mit.edu	37	12	121164932	121164932	+	Silent	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr12:121164932G>A	uc001tza.3	+	2	268	c.150G>A	c.(148-150)GAG>GAA	p.E50E	ACADS_uc010szl.1_Silent_p.E50E	NM_000017	NP_000008	P16219	ACADS_HUMAN	short-chain acyl-CoA dehydrogenase precursor	50						mitochondrial matrix	butyryl-CoA dehydrogenase activity			central_nervous_system(2)	2	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)	Lung NSC(355;0.163)			NADH(DB00157)	ACTTTGCCGAGAAGGAGTTGT	0.572000													11	184					0	0	0	0
CPB2	1361	broad.mit.edu	37	13	46656636	46656636	+	Silent	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr13:46656636G>A	uc001vaw.2	-	4	391	c.324C>T	c.(322-324)AAC>AAT	p.N108N	uc001vau.1_Intron|uc001vav.1_Intron|CPB2_uc001vax.2_Silent_p.N108N	NM_001872	NP_001863	Q96IY4	CBPB2_HUMAN	plasma carboxypeptidase B2 isoform a	108					blood coagulation|fibrinolysis|proteolysis	extracellular space	metallocarboxypeptidase activity|zinc ion binding			ovary(1)|skin(1)	2		Lung NSC(96;4.21e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)|all_neural(104;0.235)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;5.44e-05)		TGACTGTGTCGTTGGAAATCT	0.453000													7	109					0	0	0	0
RB1	5925	broad.mit.edu	37	13	49033886	49033886	+	Missense_Mutation	SNP	G	C	C	rs137853295		TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr13:49033886G>C	uc001vcb.2	+	20	2189	c.2023G>C	c.(2023-2025)GAA>CAA	p.E675Q		NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1	675	Pocket; binds T and E1A.|Domain B.				androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(7)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TGAGCACCCAGAATTAGAACA	0.423000		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			6	87					0	0	0	0
OR4M1	441670	broad.mit.edu	37	14	20248859	20248859	+	Silent	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr14:20248859C>T	uc010tku.1	+	1	378	c.378C>T	c.(376-378)ATC>ATT	p.I126I		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	126	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATGCTGCTATCTGCCGACCCC	0.507000													19	512					0	0	0	0
ARHGAP5	394	broad.mit.edu	37	14	32561983	32561983	+	Missense_Mutation	SNP	A	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr14:32561983A>G	uc001wrl.2	+	2	2347	c.2108A>G	c.(2107-2109)CAG>CGG	p.Q703R	ARHGAP5_uc001wrm.2_Missense_Mutation_p.Q703R|ARHGAP5_uc001wrn.2_Missense_Mutation_p.Q703R|ARHGAP5_uc001wro.2_Intron|ARHGAP5_uc001wrp.2_Intron	NM_001173	NP_001025226	Q13017	RHG05_HUMAN	Rho GTPase activating protein 5 isoform b	703					cell adhesion|Rho protein signal transduction	cytosol|membrane	GTP binding|GTPase activity|Rho GTPase activator activity|SH2 domain binding			ovary(4)|central_nervous_system(1)	5	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.186)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0952)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00566)		CTGGCTAATCAGAGAGATTCC	0.373000													4	49					0	0	0	0
MIPOL1	145282	broad.mit.edu	37	14	37777588	37777588	+	Missense_Mutation	SNP	C	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr14:37777588C>G	uc001wuc.2	+	10	1195	c.692C>G	c.(691-693)GCA>GGA	p.A231G	MIPOL1_uc010amr.2_Intron|MIPOL1_uc001wub.3_Missense_Mutation_p.A200G|MIPOL1_uc001wud.2_Missense_Mutation_p.A231G|MIPOL1_uc010ams.2_Missense_Mutation_p.A231G|MIPOL1_uc001wue.2_Missense_Mutation_p.A200G|MIPOL1_uc010amt.2_Missense_Mutation_p.A50G	NM_138731	NP_620059	Q8TD10	MIPO1_HUMAN	mirror-image polydactyly 1	231										ovary(1)|central_nervous_system(1)	2	Breast(36;0.119)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;6.03e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.047)|all cancers(34;0.0953)|LUSC - Lung squamous cell carcinoma(13;0.0975)|BRCA - Breast invasive adenocarcinoma(188;0.196)	GBM - Glioblastoma multiforme(112;0.0358)		ATAAACAATGCAGACACAGGG	0.313000													5	128					0	0	0	0
ESR2	2100	broad.mit.edu	37	14	64716327	64716327	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr14:64716327G>A	uc001xha.1	-	7	1630	c.1162C>T	c.(1162-1164)CGA>TGA	p.R388*	ESR2_uc001xgu.2_Nonsense_Mutation_p.R388*|ESR2_uc001xgv.2_Nonsense_Mutation_p.R388*|ESR2_uc001xgw.2_RNA|ESR2_uc001xgx.2_Nonsense_Mutation_p.R388*|ESR2_uc001xgy.1_Nonsense_Mutation_p.R388*|ESR2_uc001xgz.1_Nonsense_Mutation_p.R388*|ESR2_uc010aqb.1_RNA|ESR2_uc010aqc.1_Intron|ESR2_uc010aqd.1_Intron	NM_001437	NP_001428	Q92731	ESR2_HUMAN	estrogen receptor beta isoform 1	388	Steroid-binding.				cell-cell signaling|negative regulation of cell growth|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	mitochondrion|nucleoplasm	enzyme binding|estrogen receptor activity|receptor antagonist activity|sequence-specific DNA binding transcription factor activity|steroid binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3				all cancers(60;0.00916)|OV - Ovarian serous cystadenocarcinoma(108;0.0111)|BRCA - Breast invasive adenocarcinoma(234;0.0437)	Bicalutamide(DB01128)|Estradiol(DB00783)|Estramustine(DB01196)|Raloxifene(DB00481)|Tamoxifen(DB00675)|Trilostane(DB01108)	TTTAACTCTCGAAACCTTGAA	0.423000													10	62					0	0	0	0
SPTB	6710	broad.mit.edu	37	14	65234494	65234494	+	Missense_Mutation	SNP	C	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr14:65234494C>G	uc001xht.2	-	29	6160	c.6106G>C	c.(6106-6108)GAC>CAC	p.D2036H	SPTB_uc001xhr.2_Missense_Mutation_p.D2036H|SPTB_uc001xhs.2_Missense_Mutation_p.D2036H|SPTB_uc001xhu.2_Missense_Mutation_p.D2036H|SPTB_uc010aqi.2_Missense_Mutation_p.D697H	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	2036	Spectrin 17.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		TGTCCAAAGTCCCCGCTGGCC	0.617000													4	74					0	0	0	0
FLRT2	23768	broad.mit.edu	37	14	86088748	86088748	+	Missense_Mutation	SNP	A	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr14:86088748A>G	uc001xvr.2	+	2	1657	c.890A>G	c.(889-891)GAT>GGT	p.D297G	FLRT2_uc010atd.2_Missense_Mutation_p.D297G	NM_013231	NP_037363	O43155	FLRT2_HUMAN	fibronectin leucine rich transmembrane protein 2	297	Extracellular (Potential).|LRR 10.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			ovary(3)|haematopoietic_and_lymphoid_tissue(1)	4				BRCA - Breast invasive adenocarcinoma(234;0.0319)		GGGGTTTTTGATAATCTCTCC	0.443000													21	234					0	0	0	0
TTBK2	146057	broad.mit.edu	37	15	43122171	43122171	+	Missense_Mutation	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr15:43122171G>A	uc001zqo.2	-	5	836	c.397C>T	c.(397-399)CAT>TAT	p.H133Y	TTBK2_uc010bcy.2_Missense_Mutation_p.H64Y|TTBK2_uc001zqp.2_Missense_Mutation_p.H133Y|TTBK2_uc010bcz.1_Missense_Mutation_p.H133Y	NM_173500	NP_775771	Q6IQ55	TTBK2_HUMAN	tau tubulin kinase 2	133	Protein kinase.				cell death		ATP binding|protein serine/threonine kinase activity			ovary(2)|lung(2)|stomach(1)|pancreas(1)|skin(1)	7		all_cancers(109;6.11e-16)|all_epithelial(112;5.5e-14)|Lung NSC(122;1.76e-08)|all_lung(180;6.04e-08)|Melanoma(134;0.0179)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;3.23e-07)		CCCACAGAATGAATGCTTTCA	0.458000													5	49					0	0	0	0
SIN3A	25942	broad.mit.edu	37	15	75668128	75668128	+	Missense_Mutation	SNP	C	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr15:75668128C>G	uc002bai.2	-	20	3728	c.3469G>C	c.(3469-3471)GAG>CAG	p.E1157Q	SIN3A_uc002baj.2_Missense_Mutation_p.E1157Q|SIN3A_uc010uml.1_Missense_Mutation_p.E1157Q	NM_015477	NP_056292	Q96ST3	SIN3A_HUMAN	transcriptional co-repressor Sin3A	1157					blood coagulation|cellular lipid metabolic process|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus|Sin3 complex	protein binding			skin(3)|ovary(1)|lung(1)	5						TCCACATTCTCCATGGTCTTC	0.463000													6	131					0	0	0	0
ADAMTS17	170691	broad.mit.edu	37	15	100594257	100594257	+	Missense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr15:100594257G>C	uc002bvv.1	-	16	2219	c.2140C>G	c.(2140-2142)CTC>GTC	p.L714V		NM_139057	NP_620688	Q8TE56	ATS17_HUMAN	ADAM metallopeptidase with thrombospondin type 1	714	Spacer.				proteolysis	intracellular|proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.00299)|all_lung(78;0.00457)|Melanoma(26;0.00571)		OV - Ovarian serous cystadenocarcinoma(32;0.0013)|LUSC - Lung squamous cell carcinoma(107;0.132)|Lung(145;0.161)	COAD - Colon adenocarcinoma(1;0.111)|all cancers(203;0.219)		GAGTCTTTGAGAGCTAGAAAG	0.537000													11	126					0	0	0	0
C16orf73	254528	broad.mit.edu	37	16	1891862	1891862	+	Silent	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr16:1891862G>C	uc002cne.2	-	11	1111	c.993C>G	c.(991-993)CTC>CTG	p.L331L	C16orf73_uc010uvq.1_Silent_p.L331L|C16orf73_uc010uvr.1_Silent_p.L124L	NM_152764	NP_689977	Q8N635	CP073_HUMAN	hypothetical protein LOC254528 isoform 2	331					meiosis	cytoplasm					0						CATCAATGTTGAGTGTGGAAA	0.328000													4	37					0	0	0	0
CCNF	899	broad.mit.edu	37	16	2495573	2495573	+	Silent	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr16:2495573G>A	uc002cqd.1	+	10	1132	c.1044G>A	c.(1042-1044)CCG>CCA	p.P348P	CCNF_uc002cqe.1_Silent_p.P40P	NM_001761	NP_001752	P41002	CCNF_HUMAN	cyclin F	348	Cyclin N-terminal.				cell division|mitosis|negative regulation of centrosome duplication|protein ubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	centriole|nucleus|SCF ubiquitin ligase complex	protein binding			central_nervous_system(1)|kidney(1)	2		Ovarian(90;0.17)				GGCTGGTGCCGCGGTACAGGC	0.652000													5	51					0	0	0	0
SMG1	23049	broad.mit.edu	37	16	18827770	18827770	+	Missense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr16:18827770G>C	uc002dfm.2	-	58	10519	c.10156C>G	c.(10156-10158)CAG>GAG	p.Q3386E	SMG1_uc010bwb.2_Missense_Mutation_p.Q3246E|SMG1_uc010bwa.2_Missense_Mutation_p.Q2117E	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	3386					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						ATTGCCCTCTGAGTAGACATA	0.413000													4	61					0	0	0	0
ARHGAP17	55114	broad.mit.edu	37	16	24955123	24955123	+	Silent	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr16:24955123G>A	uc002dnb.2	-	15	1395	c.1302C>T	c.(1300-1302)ATC>ATT	p.I434I	ARHGAP17_uc002dna.2_Silent_p.I161I|ARHGAP17_uc002dnc.2_Silent_p.I434I|ARHGAP17_uc010vcf.1_Silent_p.I255I	NM_001006634	NP_001006635	Q68EM7	RHG17_HUMAN	nadrin isoform 1	434	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|tight junction	GTPase activator activity|SH3 domain binding				0				GBM - Glioblastoma multiforme(48;0.0407)		CATGCTGAATGATGGGTTCAA	0.428000													6	74					0	0	0	0
C16orf93	90835	broad.mit.edu	37	16	30771928	30771928	+	Missense_Mutation	SNP	C	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr16:30771928C>G	uc002dzm.2	-	3	629	c.298G>C	c.(298-300)GAG>CAG	p.E100Q	C16orf93_uc002dzn.2_Missense_Mutation_p.E100Q|C16orf93_uc002dzo.2_Missense_Mutation_p.E63Q|C16orf93_uc002dzp.2_Missense_Mutation_p.E100Q|RNF40_uc002dzq.2_5'Flank|RNF40_uc010caa.2_5'Flank|RNF40_uc010cab.2_5'Flank|RNF40_uc010vfa.1_5'Flank|RNF40_uc002dzr.2_5'Flank|RNF40_uc010vfb.1_5'Flank	NM_001014979	NP_001014979	A1A4V9	CP093_HUMAN	hypothetical protein LOC90835	100											0						AGTCCCTACTCCCTCATCTCA	0.522000													2	0					0	0	0	0
NUP93	9688	broad.mit.edu	37	16	56839414	56839414	+	Splice_Site	SNP	A	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr16:56839414A>T	uc002eka.2	+	5	482	c.361_splice	c.e5-2	p.T121_splice	NUP93_uc002ekb.2_Splice_Site|NUP93_uc010vhi.1_Splice_Site	NM_014669	NP_055484	Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa						carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(1)|lung(1)	2						CCTTTCTGGCAGACCTTCGGC	0.473000													4	45					0	0	0	0
CDH11	1009	broad.mit.edu	37	16	65032553	65032553	+	Missense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr16:65032553G>C	uc002eoi.2	-	4	869	c.435C>G	c.(433-435)TTC>TTG	p.F145L	CDH11_uc010cdn.2_RNA|CDH11_uc002eoj.2_Missense_Mutation_p.F145L|CDH11_uc010vin.1_Missense_Mutation_p.F19L|CDH11_uc010vio.1_Missense_Mutation_p.F145L	NM_001797	NP_001788	P55287	CAD11_HUMAN	cadherin 11, type 2 preproprotein	145	Extracellular (Potential).|Cadherin 1.				adherens junction organization|cell junction assembly|homophilic cell adhesion|ossification|skeletal system development	integral to membrane|plasma membrane	calcium ion binding|protein binding			lung(10)|ovary(3)|skin(1)	14		Ovarian(137;0.0973)		OV - Ovarian serous cystadenocarcinoma(108;0.205)		CCTTGACAATGAATTCCGACG	0.567000			T	USP6	aneurysmal bone cysts					TSP Lung(24;0.17)			3	65					0	0	0	0
CDH5	1003	broad.mit.edu	37	16	66423424	66423424	+	Missense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr16:66423424G>C	uc002eom.3	+	5	936	c.780G>C	c.(778-780)CAG>CAC	p.Q260H	CDH5_uc002eon.1_Missense_Mutation_p.Q260H	NM_001795	NP_001786	P33151	CADH5_HUMAN	cadherin 5, type 2 preproprotein	260	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion|regulation of establishment of cell polarity	integral to membrane|membrane fraction	beta-catenin binding|calcium ion binding|ion channel binding|receptor binding			ovary(2)|lung(2)|central_nervous_system(1)|skin(1)	6		Ovarian(137;0.0955)		OV - Ovarian serous cystadenocarcinoma(108;0.107)		TCTTCACCCAGAGTGAGCCCC	0.602000													3	40					0	0	0	0
DYNC1LI2	1783	broad.mit.edu	37	16	66759798	66759798	+	Silent	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr16:66759798C>T	uc002eqb.1	-	12	1342	c.1311G>A	c.(1309-1311)TTG>TTA	p.L437L	DYNC1LI2_uc010vis.1_Silent_p.L360L	NM_006141	NP_006132	O43237	DC1L2_HUMAN	dynein, cytoplasmic, light intermediate	437					transport	centrosome|cytoplasmic dynein complex|microtubule	ATP binding|motor activity			central_nervous_system(3)|skin(1)	4		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0907)|Epithelial(162;0.212)		TCTTTTTACTCAACAGACTGT	0.458000													7	187					0	0	0	0
NFAT5	10725	broad.mit.edu	37	16	69689635	69689635	+	Missense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr16:69689635G>C	uc002exm.1	+	5	2283	c.1075G>C	c.(1075-1077)GAA>CAA	p.E359Q	NFAT5_uc002exh.1_Missense_Mutation_p.E153Q|NFAT5_uc002exi.2_Missense_Mutation_p.E283Q|NFAT5_uc002exj.1_Missense_Mutation_p.E283Q|NFAT5_uc002exk.1_Missense_Mutation_p.E283Q|NFAT5_uc002exl.1_Missense_Mutation_p.E377Q|NFAT5_uc002exn.1_Missense_Mutation_p.E377Q	NM_006599	NP_006590	O94916	NFAT5_HUMAN	nuclear factor of activated T-cells 5 isoform c	359	RHD.				excretion|signal transduction|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						TCCTTGCAAAGAAGTGGACAT	0.423000													3	71					0	0	0	0
VAT1L	57687	broad.mit.edu	37	16	77896753	77896753	+	Missense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr16:77896753G>C	uc002ffg.1	+	4	785	c.688G>C	c.(688-690)GAC>CAC	p.D230H		NM_020927	NP_065978	Q9HCJ6	VAT1L_HUMAN	vesicle amine transport protein 1 homolog (T.	230							oxidoreductase activity|zinc ion binding			central_nervous_system(1)	1						CCACCTCTTTGACAGAAATGC	0.473000													4	112					0	0	0	0
CNTROB	116840	broad.mit.edu	37	17	7838431	7838431	+	Missense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr17:7838431G>C	uc002gjq.2	+	5	1481	c.562G>C	c.(562-564)GAT>CAT	p.D188H	CNTROB_uc002gjp.2_Missense_Mutation_p.D188H|CNTROB_uc002gjr.2_Missense_Mutation_p.D90H|CNTROB_uc010vum.1_5'Flank	NM_053051	NP_444279	Q8N137	CNTRB_HUMAN	centrobin, centrosomal BRCA2 interacting protein	188					centriole replication|centrosome separation|cytokinesis	centriole	protein domain specific binding			breast(1)|central_nervous_system(1)	2		Prostate(122;0.173)				GGGGCTGAGAGATGCATTGGA	0.542000													3	65					0	0	0	0
KRBA2	124751	broad.mit.edu	37	17	8273686	8273686	+	Missense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr17:8273686G>C	uc002glf.1	-	2	251	c.245C>G	c.(244-246)TCC>TGC	p.S82C	KRBA2_uc002glg.1_5'UTR	NM_213597	NP_998762	Q6ZNG9	KRBA2_HUMAN	KRAB-A domain containing 2	82	KRAB.				DNA integration|regulation of transcription, DNA-dependent	intracellular	DNA binding				0						AGGCATCATGGAGAGCTGTAA	0.403000													5	78					0	0	0	0
KRBA2	124751	broad.mit.edu	37	17	8274828	8274828	+	Missense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr17:8274828G>C	uc002glf.1	-	1	31	c.25C>G	c.(25-27)CTT>GTT	p.L9V	KRBA2_uc002glg.1_Intron	NM_213597	NP_998762	Q6ZNG9	KRBA2_HUMAN	KRAB-A domain containing 2	9					DNA integration|regulation of transcription, DNA-dependent	intracellular	DNA binding				0						GAAGAGACAAGAGAGGGCACC	0.483000													3	56					0	0	0	0
FAM83G	644815	broad.mit.edu	37	17	18881189	18881189	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr17:18881189G>C	uc002guw.2	-	5	1957	c.1790C>G	c.(1789-1791)TCA>TGA	p.S597*	SLC5A10_uc002gur.1_Intron|SLC5A10_uc002guu.1_Intron|SLC5A10_uc002gut.1_Intron|SLC5A10_uc002guv.1_Intron|SLC5A10_uc010vyl.1_Intron	NM_001039999	NP_001035088	A6ND36	FA83G_HUMAN	hypothetical protein LOC644815	597										ovary(1)|central_nervous_system(1)	2						GGAGCTGCCTGAGTGGCTGTC	0.642000													11	68					0	0	0	0
TNFAIP1	7126	broad.mit.edu	37	17	26669278	26669278	+	Missense_Mutation	SNP	C	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr17:26669278C>G	uc002hax.1	+	6	543	c.524C>G	c.(523-525)TCT>TGT	p.S175C	TNFAIP1_uc002hay.2_Missense_Mutation_p.S175C|TNFAIP1_uc010waf.1_Missense_Mutation_p.S71C	NM_021137	NP_066960	Q13829	BACD2_HUMAN	tumor necrosis factor, alpha-induced protein 1	175					apoptosis|cell migration|DNA replication|embryo development|immune response|negative regulation of Rho protein signal transduction|proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination|stress fiber assembly	Cul3-RING ubiquitin ligase complex|endosome|nucleus|voltage-gated potassium channel complex	GTP-Rho binding|voltage-gated potassium channel activity				0	all_lung(13;0.000294)|Lung NSC(42;0.000964)			UCEC - Uterine corpus endometrioid carcinoma (53;0.153)		TTCAGCAACTCTGACGACCAC	0.572000													4	31					0	0	0	0
LRRC37B	114659	broad.mit.edu	37	17	30349042	30349042	+	Missense_Mutation	SNP	C	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr17:30349042C>G	uc002hgu.2	+	1	888	c.877C>G	c.(877-879)CAG>GAG	p.Q293E	LRRC37B_uc010wbx.1_Missense_Mutation_p.Q211E|LRRC37B_uc010csu.2_Missense_Mutation_p.Q293E	NM_052888	NP_443120	Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B precursor	293	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				ACAGCTCCCTCAGGAGGTAGA	0.522000													16	127					0	0	0	0
ACACA	31	broad.mit.edu	37	17	35602001	35602001	+	Missense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr17:35602001G>C	uc002hnm.2	-	20	2670	c.2479C>G	c.(2479-2481)CAG>GAG	p.Q827E	ACACA_uc002hnk.2_Missense_Mutation_p.Q749E|ACACA_uc002hnl.2_Missense_Mutation_p.Q769E|ACACA_uc002hnn.2_Missense_Mutation_p.Q827E|ACACA_uc002hno.2_Missense_Mutation_p.Q864E|ACACA_uc010cuz.2_Missense_Mutation_p.Q827E	NM_198836	NP_942133	Q13085	ACACA_HUMAN	acetyl-Coenzyme A carboxylase alpha isoform 2	827					acetyl-CoA metabolic process|energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|triglyceride biosynthetic process	cytosol	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			large_intestine(1)|ovary(1)	2		Breast(25;0.00157)|Ovarian(249;0.15)			Biotin(DB00121)	CTCACCTGCTGAACCTTGCTG	0.498000													20	295					0	0	0	0
NPEPPS	9520	broad.mit.edu	37	17	45662950	45662950	+	Missense_Mutation	SNP	C	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr17:45662950C>G	uc002ilr.3	+	6	956	c.733C>G	c.(733-735)CTG>GTG	p.L245V	NPEPPS_uc010wkt.1_Missense_Mutation_p.L241V|NPEPPS_uc010wku.1_Missense_Mutation_p.L209V|NPEPPS_uc010dba.1_Missense_Mutation_p.L90V|NPEPPS_uc010wkv.1_5'Flank	NM_006310	NP_006301	P55786	PSA_HUMAN	aminopeptidase puromycin sensitive	245					proteolysis	cytosol|nucleus	aminopeptidase activity|metallopeptidase activity|protein binding|zinc ion binding				0						GTCTACATATCTGGTGGCATT	0.403000													19	133					0	0	0	0
KCNH6	81033	broad.mit.edu	37	17	61621693	61621693	+	Missense_Mutation	SNP	C	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr17:61621693C>G	uc002jay.2	+	12	2505	c.2425C>G	c.(2425-2427)CAA>GAA	p.Q809E	KCNH6_uc010wpl.1_Missense_Mutation_p.Q650E|KCNH6_uc010wpm.1_Missense_Mutation_p.Q773E|KCNH6_uc002jaz.1_Missense_Mutation_p.Q720E	NM_030779	NP_110406	Q9H252	KCNH6_HUMAN	potassium voltage-gated channel, subfamily H,	809	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|signal transduction					skin(1)	1					Ibutilide(DB00308)	GCACAGCCCCCAAAGCCCTCA	0.617000													5	35					0	0	0	0
DDX42	11325	broad.mit.edu	37	17	61889312	61889312	+	Missense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr17:61889312G>C	uc002jbu.2	+	15	1676	c.1419G>C	c.(1417-1419)CAG>CAC	p.Q473H	DDX42_uc002jbv.2_Missense_Mutation_p.Q473H|DDX42_uc002jbw.1_Missense_Mutation_p.Q209H|DDX42_uc002jbx.2_Missense_Mutation_p.Q209H|DDX42_uc002jby.2_Missense_Mutation_p.Q19H	NM_007372	NP_031398	Q86XP3	DDX42_HUMAN	DEAD box polypeptide 42 protein	473					protein localization|regulation of anti-apoptosis	Cajal body|cytoplasm|nuclear speck	ATP binding|ATP-dependent helicase activity|protein binding|RNA binding			ovary(2)|skin(2)|large_intestine(1)	5						ATGTGACACAGATTGTGGAGA	0.443000													27	275					0	0	0	0
LOC651250	651250	broad.mit.edu	37	17	66122927	66122927	+	RNA	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr17:66122927G>C	uc002jgq.2	+	6		c.2050G>C			LOC651250_uc002kit.2_RNA|LOC651250_uc002jgo.1_Intron	NR_027418				Homo sapiens cDNA FLJ33831 fis, clone CTONG2003937.												0						CTGGGGATGAGAGCAATGGGT	0.463000													15	145					0	0	0	0
YES1	7525	broad.mit.edu	37	18	743308	743308	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr18:743308G>A	uc002kky.2	-	7	1053	c.832C>T	c.(832-834)CGA>TGA	p.R278*	YES1_uc002kkz.2_Nonsense_Mutation_p.R278*	NM_005433	NP_005424	P07947	YES_HUMAN	viral oncogene yes-1 homolog 1	278	Protein kinase.				blood coagulation|leukocyte migration|regulation of vascular permeability|T cell costimulation	cytosol|plasma membrane	ATP binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|ovary(1)	3					Dasatinib(DB01254)	ACCTCTAGTCGCAAAGATTCT	0.423000													8	55					0	0	0	0
ZNF271	10778	broad.mit.edu	37	18	32887619	32887619	+	Missense_Mutation	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr18:32887619G>A	uc002kyq.3	+	3	2023	c.1031G>A	c.(1030-1032)AGC>AAC	p.S344N	ZNF271_uc002kyp.3_Missense_Mutation_p.S344N|ZNF271_uc002kyr.3_Missense_Mutation_p.S344N	NR_024565				SubName: Full=cDNA FLJ13394 fis, clone PLACE1001304, highly similar to Homo sapiens zinc finger protein 271 (ZNF271), mRNA;												0						AAAGCCTTCAGCACATGTACT	0.438000													3	40					0	0	0	0
ZNF407	55628	broad.mit.edu	37	18	72345521	72345521	+	Missense_Mutation	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr18:72345521C>T	uc002llw.2	+	1	2603	c.2546C>T	c.(2545-2547)TCA>TTA	p.S849L	ZNF407_uc010xfc.1_Missense_Mutation_p.S849L|ZNF407_uc010dqu.1_Missense_Mutation_p.S849L|ZNF407_uc002llu.2_Missense_Mutation_p.S848L	NM_017757	NP_060227	Q9C0G0	ZN407_HUMAN	zinc finger protein 407 isoform 1	849					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Esophageal squamous(42;0.131)|Prostate(75;0.173)		BRCA - Breast invasive adenocarcinoma(31;0.184)		GGTAACATCTCACGGACGTGT	0.438000													8	74					0	0	0	0
GNA15	2769	broad.mit.edu	37	19	3155896	3155896	+	Missense_Mutation	SNP	C	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr19:3155896C>G	uc002lxf.2	+	5	948	c.690C>G	c.(688-690)ATC>ATG	p.I230M		NM_002068	NP_002059	P30679	GNA15_HUMAN	guanine nucleotide binding protein (G protein),	230					activation of phospholipase C activity by dopamine receptor signaling pathway|activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|platelet activation|protein ADP-ribosylation	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|G-protein-coupled receptor binding|GTP binding|GTPase activity|signal transducer activity			skin(2)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.04e-05)|OV - Ovarian serous cystadenocarcinoma(105;5.08e-113)|Epithelial(107;6.19e-111)|all cancers(105;6.19e-103)|BRCA - Breast invasive adenocarcinoma(158;0.00145)|STAD - Stomach adenocarcinoma(1328;0.184)		TCGCCCTCATCTACCTGGCCT	0.602000													3	48					0	0	0	0
DPY19L3	147991	broad.mit.edu	37	19	32954294	32954294	+	Missense_Mutation	SNP	G	A	A	rs148244577	byFrequency	TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr19:32954294G>A	uc002ntg.2	+	13	1521	c.1345G>A	c.(1345-1347)GTG>ATG	p.V449M	DPY19L3_uc002nth.1_Missense_Mutation_p.V449M|DPY19L3_uc002nti.1_RNA	NM_207325	NP_997208	Q6ZPD9	D19L3_HUMAN	dpy-19-like 3	449						integral to membrane				ovary(4)	4	Esophageal squamous(110;0.162)					TCAACAATCCGTGGGTAAAAT	0.338000													6	52					0	0	0	0
KIRREL2	84063	broad.mit.edu	37	19	36357106	36357106	+	Silent	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr19:36357106G>A	uc002ocb.3	+	15	2051	c.1839G>A	c.(1837-1839)CTG>CTA	p.L613L	KIRREL2_uc002obz.3_Intron|KIRREL2_uc002oca.3_Intron|KIRREL2_uc002occ.3_Silent_p.L560L|KIRREL2_uc002ocd.3_Silent_p.L575L|APLP1_uc010xsz.1_5'Flank|APLP1_uc002oce.2_5'Flank|APLP1_uc002ocf.2_5'Flank|APLP1_uc002ocg.2_5'Flank	NM_199180	NP_954649	Q6UWL6	KIRR2_HUMAN	kin of IRRE-like 2 isoform c	613	Cytoplasmic (Potential).				cell adhesion	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			GTGTGAGCCTGAGCCTTGGCG	0.607000													12	98					0	0	0	0
LTBP4	8425	broad.mit.edu	37	19	41122917	41122917	+	Missense_Mutation	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr19:41122917G>A	uc002ooh.1	+	23	3136	c.3136G>A	c.(3136-3138)GGA>AGA	p.G1046R	LTBP4_uc002oog.1_Missense_Mutation_p.G1009R|LTBP4_uc002ooi.1_Missense_Mutation_p.G979R|LTBP4_uc002ooj.1_5'UTR|LTBP4_uc002ook.1_Intron|LTBP4_uc002ool.1_Intron|LTBP4_uc002oom.1_Intron|LTBP4_uc010xvp.1_Intron	NM_001042544	NP_001036009	Q8N2S1	LTBP4_HUMAN	latent transforming growth factor beta binding	1046	Cys-rich.				growth hormone secretion|multicellular organismal development|protein folding|regulation of cell differentiation|regulation of cell growth|regulation of proteolysis|regulation of transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|glycosaminoglycan binding|integrin binding|transforming growth factor beta binding|transforming growth factor beta receptor activity			central_nervous_system(1)	1			Lung(22;0.000158)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GCCAGGGGGCGGATGCCAGGG	0.602000													8	49					0	0	0	0
CLPTM1	1209	broad.mit.edu	37	19	45490456	45490456	+	Silent	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr19:45490456G>A	uc002pai.2	+	8	828	c.813G>A	c.(811-813)GTG>GTA	p.V271V	CLPTM1_uc010ejv.1_Silent_p.V169V|CLPTM1_uc010xxf.1_Silent_p.V169V|CLPTM1_uc010xxg.1_Silent_p.V257V	NM_001294	NP_001285	O96005	CLPT1_HUMAN	cleft lip and palate associated transmembrane	271	Extracellular (Potential).				cell differentiation|multicellular organismal development|regulation of T cell differentiation in thymus	external side of plasma membrane|integral to plasma membrane				ovary(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00354)|Epithelial(262;0.187)		TCGACGCCGTGAGCGGTGACT	0.612000													17	157					0	0	0	0
SPHK2	56848	broad.mit.edu	37	19	49129394	49129394	+	Missense_Mutation	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr19:49129394G>A	uc002pjr.2	+	3	652	c.286G>A	c.(286-288)GAG>AAG	p.E96K	SPHK2_uc010xzt.1_Missense_Mutation_p.E37K|SPHK2_uc002pjs.2_Missense_Mutation_p.E96K|SPHK2_uc002pjt.2_Intron|SPHK2_uc002pju.2_Missense_Mutation_p.E60K|SPHK2_uc002pjv.2_Missense_Mutation_p.E60K|SPHK2_uc002pjw.2_Missense_Mutation_p.E158K|SPHK2_uc010xzu.1_Missense_Mutation_p.E60K	NM_020126	NP_064511	Q9NRA0	SPHK2_HUMAN	sphingosine kinase 2	96	Required for binding to sulfatide and phosphoinositides and for membrane localization.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|anti-apoptosis|cell proliferation|sphinganine-1-phosphate biosynthetic process	cytosol|lysosomal membrane|membrane fraction	ATP binding|D-erythro-sphingosine kinase activity|diacylglycerol kinase activity|Ras GTPase binding|sphinganine kinase activity			lung(1)	1		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		CCCGTTGGCCGAGGTCTCAGG	0.587000													8	47					0	0	0	0
ZNF836	162962	broad.mit.edu	37	19	52658816	52658816	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr19:52658816G>C	uc010ydi.1	-	5	2494	c.2120C>G	c.(2119-2121)TCA>TGA	p.S707*	ZNF836_uc010ydj.1_Nonsense_Mutation_p.S707*	NM_001102657	NP_001096127	Q6ZNA1	ZN836_HUMAN	zinc finger protein 836	707	C2H2-type 18; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						TGCAAGTTTTGAACTTTGGAT	0.398000													11	59					0	0	0	0
MYADM	91663	broad.mit.edu	37	19	54377026	54377026	+	Missense_Mutation	SNP	C	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr19:54377026C>G	uc002qcl.2	+	3	391	c.243C>G	c.(241-243)ATC>ATG	p.I81M	MYADM_uc002qcm.2_Missense_Mutation_p.I81M|MYADM_uc002qcn.2_Missense_Mutation_p.I81M|MYADM_uc002qco.2_Missense_Mutation_p.I81M|MYADM_uc002qcp.2_Missense_Mutation_p.I81M	NM_001020820	NP_001018656	Q96S97	MYADM_HUMAN	myeloid-associated differentiation marker	81	MARVEL 1.|Helical; (Potential).			Missing (in Ref. 4; BAC04265).		integral to membrane				ovary(1)	1	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.0488)		TGACCCTGATCATCCTCATCG	0.642000											OREG0003650	type=REGULATORY REGION|Gene=MYADM|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	6	123					0	0	0	0
FCAR	2204	broad.mit.edu	37	19	55401062	55401062	+	Missense_Mutation	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr19:55401062G>A	uc002qhr.1	+	5	894	c.697G>A	c.(697-699)GTG>ATG	p.V233M	FCAR_uc002qhs.1_RNA|FCAR_uc002qht.1_Missense_Mutation_p.V184M|FCAR_uc010esi.1_Missense_Mutation_p.V110M|FCAR_uc002qhu.1_Missense_Mutation_p.V137M|FCAR_uc002qhv.1_Missense_Mutation_p.V211M|FCAR_uc002qhw.1_Missense_Mutation_p.V221M|FCAR_uc002qhx.1_Missense_Mutation_p.V125M|FCAR_uc002qhy.1_Missense_Mutation_p.V199M|FCAR_uc002qhz.1_Missense_Mutation_p.R196H|FCAR_uc002qia.1_Missense_Mutation_p.V124M	NM_002000	NP_001991	P24071	FCAR_HUMAN	Fc alpha receptor isoform a precursor	233	Helical; (Potential).				immune response	extracellular region|integral to plasma membrane	IgA binding|receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(193;0.0443)		CCGCATGGCCGTGGCAGGACT	0.527000													31	387					0	0	0	0
ZNF274	10782	broad.mit.edu	37	19	58697097	58697097	+	Missense_Mutation	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr19:58697097G>A	uc002qrq.1	+	3	511	c.52G>A	c.(52-54)GAT>AAT	p.D18N	ZNF274_uc010yhu.1_RNA|ZNF274_uc010yhv.1_Intron|ZNF274_uc002qrr.1_Missense_Mutation_p.D18N|ZNF274_uc002qrs.1_Intron|ZNF274_uc010eum.1_5'UTR	NM_133502	NP_598009	Q96GC6	ZN274_HUMAN	zinc finger protein 274 isoform c	18	KRAB 1.				viral reproduction	centrosome|nucleolus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|zinc ion binding			ovary(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Ovarian(87;0.0443)|Breast(46;0.0889)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0168)|Lung(386;0.215)		GACCTTTGAAGATGTAACACT	0.517000													12	97					0	0	0	0
CHMP2A	27243	broad.mit.edu	37	19	59063499	59063499	+	Silent	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr19:59063499C>T	uc002qti.2	-	3	828	c.402G>A	c.(400-402)GAG>GAA	p.E134E	CHMP2A_uc002qtj.2_Silent_p.E134E|CHMP2A_uc002qtk.2_Silent_p.E134E	NM_198426	NP_940818	O43633	CHM2A_HUMAN	chromatin modifying protein 2A	134	Interaction with VPS4B.				cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane	protein domain specific binding				0		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		TATCCATGATCTCTGCCTGCC	0.512000													12	186					0	0	0	0
SOS1	6654	broad.mit.edu	37	2	39234174	39234174	+	Missense_Mutation	SNP	C	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr2:39234174C>G	uc002rrk.3	-	16	2712	c.2671G>C	c.(2671-2673)GAG>CAG	p.E891Q	SOS1_uc002rrj.3_Missense_Mutation_p.E505Q	NM_005633	NP_005624	Q07889	SOS1_HUMAN	son of sevenless homolog 1	891	Ras-GEF.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(4)|breast(3)|lung(2)|central_nervous_system(1)	10		all_hematologic(82;0.21)				AAACCTACCTCAAATGTGTGG	0.284000									Noonan_syndrome				3	87					0	0	0	0
SOS1	6654	broad.mit.edu	37	2	39234255	39234255	+	Missense_Mutation	SNP	C	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr2:39234255C>G	uc002rrk.3	-	16	2631	c.2590G>C	c.(2590-2592)GAG>CAG	p.E864Q	SOS1_uc002rrj.3_Missense_Mutation_p.E478Q	NM_005633	NP_005624	Q07889	SOS1_HUMAN	son of sevenless homolog 1	864	Ras-GEF.				apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(4)|breast(3)|lung(2)|central_nervous_system(1)	10		all_hematologic(82;0.21)				TTGTTCAACTCTTGAAAGACT	0.358000									Noonan_syndrome				11	126					0	0	0	0
KDM3A	55818	broad.mit.edu	37	2	86693679	86693679	+	Missense_Mutation	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr2:86693679G>A	uc002sri.3	+	10	1519	c.1192G>A	c.(1192-1194)GAT>AAT	p.D398N	KDM3A_uc010ytj.1_Missense_Mutation_p.D398N|KDM3A_uc010ytk.1_Missense_Mutation_p.D346N	NM_018433	NP_060903	Q9Y4C1	KDM3A_HUMAN	jumonji domain containing 1A	398					androgen receptor signaling pathway|cell differentiation|formaldehyde biosynthetic process|histone H3-K9 demethylation|hormone-mediated signaling pathway|positive regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	cytoplasm|nucleus	androgen receptor binding|iron ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			breast(2)|ovary(1)|central_nervous_system(1)|skin(1)	5						GACAAACACTGATCAGGAAAA	0.453000													15	169					0	0	0	0
MITD1	129531	broad.mit.edu	37	2	99797402	99797402	+	Missense_Mutation	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr2:99797402C>T	uc002szs.1	-	1	91	c.43G>A	c.(43-45)GCA>ACA	p.A15T	MRPL30_uc002szl.1_Intron|MRPL30_uc002szr.2_Intron|MRPL30_uc002szt.1_5'Flank|MRPL30_uc002szu.2_5'Flank|MRPL30_uc002szv.2_5'Flank	NM_138798	NP_620153	Q8WV92	MITD1_HUMAN	MIT, microtubule interacting and transport,	15	MIT.				protein transport	late endosome membrane				large_intestine(1)|ovary(1)	2						ACAGTGGCTGCAGCTGTGCTC	0.587000													5	57					0	0	0	0
EIF5B	9669	broad.mit.edu	37	2	100007051	100007051	+	Missense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr2:100007051G>C	uc002tab.2	+	17	2815	c.2631G>C	c.(2629-2631)TTG>TTC	p.L877F		NM_015904	NP_056988	O60841	IF2P_HUMAN	eukaryotic translation initiation factor 5B	877					regulation of translational initiation	cytosol	GTP binding|GTPase activity|protein binding|translation initiation factor activity			ovary(2)|pancreas(1)	3						ATGTCATCTTGATCAATGGGC	0.438000													3	80					0	0	0	0
BAZ2B	29994	broad.mit.edu	37	2	160229587	160229587	+	Silent	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr2:160229587C>T	uc002uao.2	-	27	4534	c.4182G>A	c.(4180-4182)GGG>GGA	p.G1394G	BAZ2B_uc002uap.2_Silent_p.G1358G	NM_013450	NP_038478	Q9UIF8	BAZ2B_HUMAN	bromodomain adjacent to zinc finger domain, 2B	1394					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|skin(1)	4						CTACAAAAATCCCCCCACATT	0.403000													4	49					0	0	0	0
LRP2	4036	broad.mit.edu	37	2	170050332	170050332	+	Missense_Mutation	SNP	C	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr2:170050332C>G	uc002ues.2	-	47	8982	c.8769G>C	c.(8767-8769)TGG>TGC	p.W2923C		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2923	LDL-receptor class A 21.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	CGTCACAGATCCATTCGCTTG	0.463000													5	98					0	0	0	0
NAB1	4664	broad.mit.edu	37	2	191524404	191524404	+	Missense_Mutation	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr2:191524404G>A	uc002usb.2	+	4	1074	c.502G>A	c.(502-504)GAG>AAG	p.E168K	NAB1_uc010fsc.2_Missense_Mutation_p.E168K|NAB1_uc010fsd.2_Missense_Mutation_p.E168K|NAB1_uc002usc.2_Missense_Mutation_p.E168K|NAB1_uc010zgh.1_Missense_Mutation_p.E168K	NM_005966	NP_005957	Q13506	NAB1_HUMAN	NGFI-A binding protein 1	168					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0			OV - Ovarian serous cystadenocarcinoma(117;0.00318)|Epithelial(96;0.0405)|all cancers(119;0.109)			CCATGCCACTGAGAGCGAGCA	0.627000													7	40					0	0	0	0
CASP8	841	broad.mit.edu	37	2	202151270	202151270	+	Nonsense_Mutation	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr2:202151270C>T	uc002uxr.1	+	10	1602	c.1393C>T	c.(1393-1395)CAG>TAG	p.Q465*	CASP8_uc002uxp.1_Nonsense_Mutation_p.Q482*|CASP8_uc002uxq.1_Nonsense_Mutation_p.Q450*|CASP8_uc002uxt.1_Nonsense_Mutation_p.Q524*|CASP8_uc002uxu.1_RNA|CASP8_uc002uxw.1_Nonsense_Mutation_p.Q450*|CASP8_uc002uxy.1_Intron|CASP8_uc002uxx.1_Intron|CASP8_uc010ftf.2_Nonsense_Mutation_p.Q381*	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	465					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						ACAGATGCCTCAGCCTACTTT	0.313000										HNSCC(4;0.00038)			7	40					0	0	0	0
WDR12	55759	broad.mit.edu	37	2	203772641	203772641	+	Missense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr2:203772641G>C	uc002uzl.2	-	2	833	c.83C>G	c.(82-84)TCT>TGT	p.S28C	WDR12_uc010ftt.2_Missense_Mutation_p.S28C	NM_018256	NP_060726	Q9GZL7	WDR12_HUMAN	WD repeat domain 12 protein	28					cell proliferation|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	nucleoplasm|PeBoW complex|preribosome, large subunit precursor	protein binding				0						GGCAATTTCAGAGGCAGCAGG	0.373000													3	38					0	0	0	0
SMARCAL1	50485	broad.mit.edu	37	2	217279568	217279568	+	Silent	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr2:217279568C>T	uc002vgc.3	+	3	471	c.141C>T	c.(139-141)TTC>TTT	p.F47F	SMARCAL1_uc010fvf.2_RNA|SMARCAL1_uc002vgd.3_Silent_p.F47F|SMARCAL1_uc010fvg.2_Silent_p.F47F	NM_014140	NP_054859	Q9NZC9	SMAL1_HUMAN	SWI/SNF-related matrix-associated	47					chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			ovary(3)|breast(3)|skin(1)	7		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		GCAACCCATTCCAGGCCAAGC	0.507000									Schimke_Immuno-Osseous_Dysplasia				14	181					0	0	0	0
COL6A3	1293	broad.mit.edu	37	2	238283539	238283539	+	Silent	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr2:238283539G>A	uc002vwl.2	-	8	3480	c.3195C>T	c.(3193-3195)GTC>GTT	p.V1065V	COL6A3_uc002vwo.2_Silent_p.V859V|COL6A3_uc010znj.1_Silent_p.V458V|COL6A3_uc002vwq.2_Silent_p.V859V|COL6A3_uc002vwr.2_Silent_p.V658V	NM_004369	NP_004360	P12111	CO6A3_HUMAN	alpha 3 type VI collagen isoform 1 precursor	1065	Nonhelical region.|VWFA 6.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			ovary(8)|central_nervous_system(6)|skin(2)|upper_aerodigestive_tract(1)|pancreas(1)	18		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		CGGCCACGCGGACCCGGTCCT	0.592000													9	79					0	0	0	0
ITPA	3704	broad.mit.edu	37	20	3194643	3194643	+	Missense_Mutation	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr20:3194643G>A	uc002wid.2	+	4	344	c.202G>A	c.(202-204)GTG>ATG	p.V68M	ITPA_uc002wie.2_Missense_Mutation_p.V51M|ITPA_uc002wif.2_RNA	NM_033453	NP_258412	Q9BY32	ITPA_HUMAN	inosine triphosphatase isoform a	68					nucleotide metabolic process	cytoplasm	metal ion binding|nucleoside-triphosphate diphosphatase activity|nucleotide binding			ovary(1)	1						ACAGGGGCCCGTGCTGGTTGA	0.627000													6	89					0	0	0	0
CEP250	11190	broad.mit.edu	37	20	34091328	34091328	+	Missense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr20:34091328G>C	uc002xcm.2	+	31	5802	c.5131G>C	c.(5131-5133)GAG>CAG	p.E1711Q	CEP250_uc010zve.1_Missense_Mutation_p.E1079Q	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	1711	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			GGAACGGGCAGAGGAAGGGAA	0.582000													6	122					0	0	0	0
Unknown	0	broad.mit.edu	37	22	18846098	18846098	+	RNA	SNP	G	A	A	rs9306211		TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr22:18846098G>A	uc002zoe.2	+	5		c.2460G>A			uc002zof.2_5'Flank					Homo sapiens cDNA FLJ76361 complete cds.																		ATGCCTCGGCGCTCGATCTCC	0.622000													4	30					0	0	0	0
LOC96610	96610	broad.mit.edu	37	22	22453476	22453476	+	RNA	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr22:22453476C>T	uc011aim.1	+	7		c.609C>T								Parts of antibodies, mostly variable regions.												0						GCACGCTCATCTACAGCACAA	0.587000													10	134					0	0	0	0
LOC96610	96610	broad.mit.edu	37	22	23101760	23101760	+	RNA	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr22:23101760C>T	uc011aim.1	+	214		c.11151C>T								Parts of antibodies, mostly variable regions.												0						TCTCAGGCCCCCTCCTTGCTC	0.542000													6	49					0	0	0	0
HMGXB4	10042	broad.mit.edu	37	22	35658315	35658315	+	Splice_Site	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr22:35658315G>C	uc003anl.2	+	2	107	c.-67_splice	c.e2-1		HMGXB4_uc011amh.1_Intron|HMGXB4_uc003ank.2_Splice_Site	NM_001003681	NP_001003681	Q9UGU5	HMGX4_HUMAN	high-mobility group protein 2-like 1						endosome to lysosome transport|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	NURF complex	DNA binding			breast(1)|skin(1)	2						TTGTTTCTCAGACCTGGTCCT	0.512000													11	119					0	0	0	0
RANGAP1	5905	broad.mit.edu	37	22	41652800	41652800	+	Missense_Mutation	SNP	A	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr22:41652800A>C	uc003azs.2	-	7	2273	c.803T>G	c.(802-804)GTG>GGG	p.V268G	RANGAP1_uc003azt.2_Missense_Mutation_p.V268G|RANGAP1_uc003azu.2_Missense_Mutation_p.V268G|RANGAP1_uc011aoz.1_Missense_Mutation_p.V213G	NM_002883	NP_002874	P46060	RAGP1_HUMAN	Ran GTPase activating protein 1	268					mitotic prometaphase|signal transduction	condensed chromosome kinetochore|cytosol|nuclear membrane|nuclear pore|soluble fraction|spindle pole	protein binding|Ran GTPase activator activity				0						AAAATTAATCACCTCCACCTG	0.637000													6	8					0	0	0	0
PACSIN2	11252	broad.mit.edu	37	22	43272940	43272940	+	Missense_Mutation	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr22:43272940C>T	uc010gzg.2	-	9	1327	c.1105G>A	c.(1105-1107)GAC>AAC	p.D369N	PACSIN2_uc003bdg.3_Missense_Mutation_p.D369N|PACSIN2_uc003bde.3_Missense_Mutation_p.D369N|PACSIN2_uc003bdf.3_Intron	NM_007229	NP_009160	Q9UNF0	PACN2_HUMAN	protein kinase C and casein kinase substrate in	369					actin cytoskeleton organization|endocytosis	cytoplasmic membrane-bounded vesicle	transporter activity				0		Glioma(61;0.222)				CTGCCCGTGTCGTCCTCATCC	0.567000													12	164					0	0	0	0
PLXNB2	23654	broad.mit.edu	37	22	50728422	50728422	+	Missense_Mutation	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr22:50728422C>T	uc003bkv.3	-	3	698	c.592G>A	c.(592-594)GAA>AAA	p.E198K		NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	198	Extracellular (Potential).|Sema.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GTGTAGGCTTCAAAGGCCTCC	0.607000													5	57					0	0	0	0
TREX1	11277	broad.mit.edu	37	3	48508971	48508971	+	Missense_Mutation	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr3:48508971G>A	uc003ctj.2	+	2	2339	c.1082G>A	c.(1081-1083)GGA>GAA	p.G361E	TREX1_uc010hjy.2_Missense_Mutation_p.G306E|TREX1_uc003ctk.2_Missense_Mutation_p.G167E|TREX1_uc010hjz.2_Missense_Mutation_p.G306E|TREX1_uc010hka.2_Missense_Mutation_p.G361E	NM_033629	NP_338599	Q9NSU2	TREX1_HUMAN	three prime repair exonuclease 1 isoform b	361			G -> A (in systemic lupus erythematosus).		cell death|DNA recombination|DNA replication|mismatch repair	nuclear envelope	3'-5'-exodeoxyribonuclease activity|exodeoxyribonuclease III activity|metal ion binding|MutLalpha complex binding|MutSalpha complex binding|protein homodimerization activity|single-stranded DNA binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000286)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00605)		ACACTGTATGGACTATCCCTG	0.592000								Direct_reversal_of_damage|Editing_and_processing_nucleases					6	59					0	0	0	0
DALRD3	55152	broad.mit.edu	37	3	49053656	49053656	+	Missense_Mutation	SNP	C	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr3:49053656C>G	uc003cvk.1	-	9	1284	c.1264G>C	c.(1264-1266)GAA>CAA	p.E422Q	DALRD3_uc003cvl.1_Missense_Mutation_p.E422Q|DALRD3_uc003cvm.1_Missense_Mutation_p.E255Q|DALRD3_uc010hko.1_Missense_Mutation_p.E255Q|DALRD3_uc011bca.1_Missense_Mutation_p.E422Q	NM_001009996	NP_001009996	Q5D0E6	DALD3_HUMAN	DALR anticodon binding domain containing 3	422					arginyl-tRNA aminoacylation	cytoplasm	arginine-tRNA ligase activity|ATP binding				0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		AGACCTTGTTCCATACTACAC	0.502000													6	67					0	0	0	0
RASSF1	11186	broad.mit.edu	37	3	50369058	50369058	+	Missense_Mutation	SNP	C	T	T	rs148222115	byFrequency	TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr3:50369058C>T	uc003dad.1	-	4	835	c.704G>A	c.(703-705)CGA>CAA	p.R235Q	RASSF1_uc003daa.1_Missense_Mutation_p.R80Q|RASSF1_uc003dab.1_Missense_Mutation_p.R161Q|RASSF1_uc003dac.2_Missense_Mutation_p.R80Q|RASSF1_uc003dae.1_Missense_Mutation_p.R231Q|RASSF1_uc010hlk.1_RNA|RASSF1_uc003daf.1_Missense_Mutation_p.R80Q	NM_170714	NP_733832	Q9NS23	RASF1_HUMAN	Ras association domain family 1 isoform D	235	Ras-associating.				cell cycle arrest|negative regulation of cell cycle arrest|positive regulation of protein ubiquitination|protein stabilization|Ras protein signal transduction|response to DNA damage stimulus	microtubule|microtubule cytoskeleton|microtubule organizing center|nucleus|spindle pole	identical protein binding|protein binding|protein N-terminus binding|zinc ion binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000278)|OV - Ovarian serous cystadenocarcinoma(275;0.0015)|KIRC - Kidney renal clear cell carcinoma(197;0.00551)|Kidney(197;0.00621)		CAAGAACTTTCGCAGCAGGGC	0.597000													11	77					0	0	0	0
PRICKLE2	166336	broad.mit.edu	37	3	64145632	64145632	+	Missense_Mutation	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr3:64145632C>T	uc003dmf.2	-	4	966	c.380G>A	c.(379-381)GGA>GAA	p.G127E		NM_198859	NP_942559	Q7Z3G6	PRIC2_HUMAN	prickle-like 2	127						cytoplasm|nuclear membrane	zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(201;0.136)		BRCA - Breast invasive adenocarcinoma(55;0.000971)|KIRC - Kidney renal clear cell carcinoma(15;0.00443)|Kidney(15;0.00497)		ACAAATAGCTCCTGTCATGGT	0.438000													15	151					0	0	0	0
GPR156	165829	broad.mit.edu	37	3	119885902	119885902	+	Missense_Mutation	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr3:119885902C>T	uc011bjf.1	-	9	2422	c.2422G>A	c.(2422-2424)GAC>AAC	p.D808N	GPR156_uc011bjg.1_Missense_Mutation_p.D804N	NM_153002	NP_694547	Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	808	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.19)		GGTTTCAAGTCATCTTTGAAG	0.537000													9	300					0	0	0	0
MYLK	4638	broad.mit.edu	37	3	123452808	123452808	+	Silent	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr3:123452808G>A	uc003ego.2	-	10	1317	c.1035C>T	c.(1033-1035)ATC>ATT	p.I345I	MYLK_uc011bjw.1_Silent_p.I345I|MYLK_uc003egp.2_Silent_p.I345I|MYLK_uc003egq.2_Silent_p.I345I|MYLK_uc003egr.2_Silent_p.I345I|MYLK_uc003egs.2_Silent_p.I169I	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	345					aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		CCTGCAGGGTGATGGAGCTGG	0.637000													7	116					0	0	0	0
SEC61A1	29927	broad.mit.edu	37	3	127786876	127786876	+	Missense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr3:127786876G>C	uc003ekb.2	+	11	1402	c.1218G>C	c.(1216-1218)GAG>GAC	p.E406D	RUVBL1_uc003eke.2_Intron|RUVBL1_uc003ekf.2_Intron|SEC61A1_uc003ekc.2_Missense_Mutation_p.E353D|SEC61A1_uc003ekd.2_Missense_Mutation_p.E286D|SEC61A1_uc003ekg.2_Missense_Mutation_p.E100D	NM_013336	NP_037468	P61619	S61A1_HUMAN	Sec61 alpha 1 subunit	406	Cytoplasmic (Potential).				protein targeting to ER	integral to endoplasmic reticulum membrane	P-P-bond-hydrolysis-driven protein transmembrane transporter activity|protein binding|ribosome binding			ovary(1)	1						GCCACCGAGAGACCTCCATGG	0.572000											OREG0015775	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	3	74					0	0	0	0
ACAD9	28976	broad.mit.edu	37	3	128631364	128631364	+	Missense_Mutation	SNP	C	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr3:128631364C>G	uc003ela.3	+	18	1982	c.1780C>G	c.(1780-1782)CTA>GTA	p.L594V	KIAA1257_uc003elg.1_Intron|ACAD9_uc011bks.1_Missense_Mutation_p.L471V|ACAD9_uc003elb.2_Missense_Mutation_p.L471V|ACAD9_uc003eld.1_RNA|ACAD9_uc003ele.2_Missense_Mutation_p.L246V|uc003elf.1_Intron	NM_014049	NP_054768	Q9H845	ACAD9_HUMAN	acyl-Coenzyme A dehydrogenase family, member 9	594						mitochondrion	acyl-CoA dehydrogenase activity|flavin adenine dinucleotide binding			ovary(2)|central_nervous_system(1)	3						TCCAGAAAACCTAGATGAGCA	0.502000													12	57					0	0	0	0
HLTF	6596	broad.mit.edu	37	3	148781309	148781309	+	Missense_Mutation	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr3:148781309C>T	uc003ewq.1	-	10	1287	c.1069G>A	c.(1069-1071)GCA>ACA	p.A357T	HLTF_uc003ewr.1_Missense_Mutation_p.A357T|HLTF_uc003ews.1_Missense_Mutation_p.A357T|HLTF_uc010hve.1_Missense_Mutation_p.A357T	NM_139048	NP_620636	Q14527	HLTF_HUMAN	helicase-like transcription factor	357					chromatin modification|transcription, DNA-dependent	nucleus	ATP binding|DNA binding|helicase activity|ligase activity|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)			CATCTAGATGCGTCTATTTCA	0.343000													5	58					0	0	0	0
SMC4	10051	broad.mit.edu	37	3	160149430	160149430	+	Splice_Site	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr3:160149430G>A	uc003fdh.2	+	21	3228	c.3115_splice	c.e21-1	p.I1039_splice	IFT80_uc003fda.2_Intron|SMC4_uc003fdi.2_Splice_Site_p.I1014_splice|SMC4_uc003fdj.2_Splice_Site_p.I1039_splice|SMC4_uc010hwd.2_Splice_Site_p.I981_splice|SMC4_uc003fdl.2_Splice_Site_p.I742_splice	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes						cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			TGAACTTTTAGATTTCAAAAA	0.313000													4	66					0	0	0	0
TTC14	151613	broad.mit.edu	37	3	180321060	180321060	+	Silent	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr3:180321060G>A	uc003fkk.2	+	3	567	c.435G>A	c.(433-435)TTG>TTA	p.L145L	TTC14_uc003fkl.2_Silent_p.L145L|TTC14_uc003fkm.2_Silent_p.L145L	NM_133462	NP_597719	Q96N46	TTC14_HUMAN	tetratricopeptide repeat domain 14 isoform a	145	S1 motif.						RNA binding			ovary(1)	1	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			TCATGGTGTTGATCTGTTTAG	0.373000													5	88					0	0	0	0
FGFR3	2261	broad.mit.edu	37	4	1801486	1801486	+	Missense_Mutation	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr4:1801486C>T	uc003gdr.3	+	4	648	c.392C>T	c.(391-393)TCG>TTG	p.S131L	FGFR3_uc003gdu.2_Missense_Mutation_p.S131L|FGFR3_uc003gds.3_Missense_Mutation_p.S131L|FGFR3_uc003gdq.3_Missense_Mutation_p.S131L|FGFR3_uc010icb.1_5'Flank|FGFR3_uc003gdt.1_5'Flank	NM_000142	NP_000133	P22607	FGFR3_HUMAN	fibroblast growth factor receptor 3 isoform 1	131	Extracellular (Potential).				bone maturation|cell growth|insulin receptor signaling pathway|JAK-STAT cascade|MAPKKK cascade|negative regulation of developmental growth|positive regulation of cell proliferation	integral to plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|identical protein binding	p.S131L(1)		urinary_tract(2177)|skin(314)|upper_aerodigestive_tract(57)|haematopoietic_and_lymphoid_tissue(24)|prostate(9)|cervix(6)|central_nervous_system(4)|large_intestine(3)|lung(3)|testis(2)|pancreas(1)	2600		Breast(71;0.212)|all_epithelial(65;0.241)	all cancers(2;0.000145)|OV - Ovarian serous cystadenocarcinoma(23;0.0019)|Epithelial(3;0.00221)|GBM - Glioblastoma multiforme(2;0.234)		Palifermin(DB00039)	GCTCCATCCTCGGGAGATGAC	0.677000		1	Mis|T	IGH@|ETV6	bladder|MM|T-cell lymphoma		Hypochondroplasia|Thanatophoric dysplasia		Muenke_syndrome|Saethre-Chotzen_syndrome				5	40					0	0	0	0
CCKAR	886	broad.mit.edu	37	4	26490898	26490898	+	Missense_Mutation	SNP	G	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr4:26490898G>T	uc003gse.1	-	2	474	c.321C>A	c.(319-321)TTC>TTA	p.F107L		NM_000730	NP_000721	P32238	CCKAR_HUMAN	cholecystokinin A receptor	107	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|elevation of cytosolic calcium ion concentration|response to nutrient	integral to plasma membrane	cholecystokinin receptor activity			lung(3)|pancreas(1)	4		Breast(46;0.0503)			Ceruletide(DB00403)	TCCCGAAGATGAAATCCTTGA	0.562000													7	115					8.12818e-05	0.000383071	1	0
PDGFRA	5156	broad.mit.edu	37	4	55144560	55144560	+	Missense_Mutation	SNP	C	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr4:55144560C>G	uc003han.3	+	15	2365	c.2034C>G	c.(2032-2034)TTC>TTG	p.F678L	PDGFRA_uc003haa.2_Missense_Mutation_p.F438L|PDGFRA_uc010igq.1_Missense_Mutation_p.F572L|PDGFRA_uc003ham.2_RNA|PDGFRA_uc003hao.1_Missense_Mutation_p.F57L	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	678	Protein kinase.|Cytoplasmic (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	AGTATTGCTTCTATGGAGATT	0.433000			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			4	88					0	0	0	0
UGT2B11	10720	broad.mit.edu	37	4	70074139	70074139	+	Missense_Mutation	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr4:70074139G>A	uc003heh.2	-	3	941	c.932C>T	c.(931-933)TCA>TTA	p.S311L	uc003hei.1_Intron	NM_001073	NP_001064	O75310	UDB11_HUMAN	UDP glucuronosyltransferase 2 family,	311					estrogen metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			ovary(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	3						ACTTATCACTGACCCCAGAGA	0.418000													19	189					0	0	0	0
USO1	8615	broad.mit.edu	37	4	76708301	76708301	+	Silent	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr4:76708301G>A	uc003hiu.2	+	9	1117	c.942G>A	c.(940-942)CAG>CAA	p.Q314Q	USO1_uc003hiv.2_Silent_p.Q149Q|USO1_uc003hiw.2_Silent_p.Q149Q	NM_003715	NP_003706	O60763	USO1_HUMAN	USO1 homolog, vesicle docking protein	314	ARM 6.|Globular head.				intracellular protein transport|vesicle fusion with Golgi apparatus	cytosol|Golgi membrane	protein binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			GGTTATTGCAGCAGCTTTGTA	0.468000													7	104					0	0	0	0
NAP1L5	266812	broad.mit.edu	37	4	89618637	89618637	+	Missense_Mutation	SNP	C	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr4:89618637C>A	uc003hrx.2	-	1	387	c.269G>T	c.(268-270)CGA>CTA	p.R90L	HERC3_uc003hrw.1_Intron|HERC3_uc011cdn.1_Intron|HERC3_uc011cdo.1_Intron	NM_153757	NP_715638	Q96NT1	NP1L5_HUMAN	nucleosome assembly protein 1-like 5	90	Potential.				nucleosome assembly	nucleus	protein binding			skin(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000181)		CTTATCGCATCGCTTCTGCAG	0.458000													12	119					6.40141e-05	0.000303191	1	0
FAT4	79633	broad.mit.edu	37	4	126239528	126239528	+	Missense_Mutation	SNP	C	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr4:126239528C>G	uc003ifj.3	+	1	1962	c.1962C>G	c.(1960-1962)TTC>TTG	p.F654L		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	654	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						AGCAAGCCTTCTACTCCCTGT	0.517000													8	59					0	0	0	0
SLC7A11	23657	broad.mit.edu	37	4	139153472	139153472	+	Missense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr4:139153472G>C	uc011chb.1	-	3	749	c.469C>G	c.(469-471)CAA>GAA	p.Q157E		NM_014331	NP_055146	Q9UPY5	XCT_HUMAN	solute carrier family 7, (cationic amino acid	157	Extracellular (Potential).				blood coagulation|cellular nitrogen compound metabolic process|leukocyte migration|response to toxin	integral to membrane|plasma membrane	cystine:glutamate antiporter activity|protein binding			skin(1)	1	all_hematologic(180;0.166)				L-Cystine(DB00138)|L-Glutamic Acid(DB00142)|Sulfasalazine(DB00795)	ATTTCACATTGAATAAAAAAT	0.368000													10	68					0	0	0	0
KIAA0922	23240	broad.mit.edu	37	4	154544100	154544100	+	Missense_Mutation	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr4:154544100G>A	uc003inm.3	+	29	3959	c.3907G>A	c.(3907-3909)GAT>AAT	p.D1303N	KIAA0922_uc010ipp.2_Missense_Mutation_p.D1304N|KIAA0922_uc010ipq.2_Missense_Mutation_p.D1072N	NM_015196	NP_056011	A2VDJ0	T131L_HUMAN	hypothetical protein LOC23240 isoform 2	1303	Ser-rich.|Cytoplasmic (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	all_hematologic(180;0.093)	Renal(120;0.118)				GTTCTGCTCCGATTCCAGCTC	0.562000													14	121					0	0	0	0
ODZ3	55714	broad.mit.edu	37	4	183713749	183713749	+	Missense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr4:183713749G>C	uc003ivd.1	+	25	5961	c.5924G>C	c.(5923-5925)GGA>GCA	p.G1975A		NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	1975	Extracellular (Potential).|YD 11.				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		GAAACAGCAGGAGTCCTAAAG	0.408000													10	187					0	0	0	0
FAT1	2195	broad.mit.edu	37	4	187516868	187516868	+	Missense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr4:187516868G>C	uc003izf.2	-	26	13301	c.13113C>G	c.(13111-13113)TTC>TTG	p.F4371L	FAT1_uc010isn.2_5'UTR|FAT1_uc003ize.2_Missense_Mutation_p.F262L	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	4371	Cytoplasmic (Potential).				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ATTCGGACTGGAAGGAGCTCA	0.512000										HNSCC(5;0.00058)			9	90					0	0	0	0
FAT1	2195	broad.mit.edu	37	4	187516881	187516881	+	Missense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr4:187516881G>C	uc003izf.2	-	26	13288	c.13100C>G	c.(13099-13101)TCT>TGT	p.S4367C	FAT1_uc010isn.2_5'UTR|FAT1_uc003ize.2_Missense_Mutation_p.S258C	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	4367	Cytoplasmic (Potential).				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GGAGCTCAGAGACTGCACTTC	0.517000										HNSCC(5;0.00058)			10	90					0	0	0	0
FAT1	2195	broad.mit.edu	37	4	187630459	187630459	+	Missense_Mutation	SNP	C	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr4:187630459C>G	uc003izf.2	-	2	711	c.523G>C	c.(523-525)GAT>CAT	p.D175H	FAT1_uc010iso.1_Missense_Mutation_p.D175H	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	175	Extracellular (Potential).|Cadherin 2.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						ATGTCTGCATCCGTGGCGCTG	0.433000										HNSCC(5;0.00058)			20	162					0	0	0	0
SLC45A2	51151	broad.mit.edu	37	5	33963899	33963899	+	Nonsense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr5:33963899G>C	uc003jid.2	-	3	877	c.785C>G	c.(784-786)TCA>TGA	p.S262*	SLC45A2_uc003jie.2_Nonsense_Mutation_p.S262*|SLC45A2_uc003jif.3_Intron|SLC45A2_uc011coe.1_Intron	NM_016180	NP_057264	Q9UMX9	S45A2_HUMAN	membrane-associated transporter protein isoform	262	Cytoplasmic (Potential).				melanin biosynthetic process|response to stimulus|transmembrane transport|visual perception	integral to membrane|melanosome membrane				ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						CATTCCATCTGATGACAATGG	0.443000													6	117					0	0	0	0
CMYA5	202333	broad.mit.edu	37	5	79026056	79026056	+	Missense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr5:79026056G>C	uc003kgc.2	+	2	1540	c.1468G>C	c.(1468-1470)GAG>CAG	p.E490Q		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	490	Glu-rich.					perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		AAACATGCTTGAGCCATCCAT	0.458000													15	125					0	0	0	0
SLCO4C1	353189	broad.mit.edu	37	5	101597639	101597639	+	Missense_Mutation	SNP	G	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr5:101597639G>T	uc003knm.2	-	5	1285	c.998C>A	c.(997-999)TCT>TAT	p.S333Y		NM_180991	NP_851322	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family,	333	Helical; Name=6; (Potential).				cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|pancreas(1)	4		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		TGGAAAGCAAGAAAAAGGTAT	0.368000													4	39					0.00024832	0.00115883	1	0
SLCO6A1	133482	broad.mit.edu	37	5	101724493	101724493	+	Missense_Mutation	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr5:101724493C>T	uc003knn.2	-	12	2088	c.1916G>A	c.(1915-1917)GGA>GAA	p.G639E	SLCO6A1_uc003kno.2_Missense_Mutation_p.G386E|SLCO6A1_uc003knp.2_Missense_Mutation_p.G639E|SLCO6A1_uc003knq.2_Missense_Mutation_p.G577E	NM_173488	NP_775759	Q86UG4	SO6A1_HUMAN	solute carrier organic anion transporter family,	639	Helical; Name=11; (Potential).					integral to membrane|plasma membrane	transporter activity			ovary(3)|skin(3)|central_nervous_system(1)	7		all_cancers(142;8e-09)|all_epithelial(76;2.83e-12)|Prostate(80;0.00125)|Colorectal(57;0.00342)|Ovarian(225;0.024)|Lung NSC(167;0.0259)|all_lung(232;0.0323)		Epithelial(69;1.47e-15)|COAD - Colon adenocarcinoma(37;0.0113)		AGAAGTTTCTCCTGACATTTT	0.323000													5	22					0	0	0	0
CSF2	1437	broad.mit.edu	37	5	131411512	131411512	+	Silent	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr5:131411512C>T	uc003kwf.2	+	4	434	c.402C>T	c.(400-402)ATC>ATT	p.I134I		NM_000758	NP_000749	P04141	CSF2_HUMAN	colony stimulating factor 2 precursor	134					immune response|negative regulation of cytolysis|positive regulation of DNA replication|positive regulation of interleukin-23 production|positive regulation of macrophage derived foam cell differentiation|positive regulation of podosome assembly|positive regulation of tyrosine phosphorylation of Stat5 protein	extracellular space	cytokine activity|granulocyte macrophage colony-stimulating factor receptor binding|growth factor activity				0		all_cancers(142;4.28e-07)|all_lung(232;2.81e-05)|Lung NSC(810;0.000693)|Lung SC(612;0.122)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)		Sargramostim(DB00020)	TGCTTGTCATCCCCTTTGACT	0.463000													5	115					0	0	0	0
PCDHA9	9752	broad.mit.edu	37	5	140229699	140229699	+	Missense_Mutation	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr5:140229699C>T	uc003lhu.2	+	1	2343	c.1619C>T	c.(1618-1620)GCG>GTG	p.A540V	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lht.1_Missense_Mutation_p.A540V	NM_031857	NP_114063	Q9Y5H5	PCDA9_HUMAN	protocadherin alpha 9 isoform 1 precursor	540	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding|protein binding			large_intestine(2)|ovary(2)|skin(1)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCGCGACGCGGGCGTGCCG	0.667000													20	154					0	0	0	0
PCDHA13	56136	broad.mit.edu	37	5	140264038	140264038	+	Missense_Mutation	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr5:140264038G>A	uc003lif.2	+	1	2185	c.2185G>A	c.(2185-2187)GAG>AAG	p.E729K	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Missense_Mutation_p.E729K|PCDHA13_uc003lid.2_Missense_Mutation_p.E729K	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	729	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ACCGCCCACCGAGGGCGCGTG	0.647000													6	125					0	0	0	0
PCDHAC1	56135	broad.mit.edu	37	5	140306523	140306523	+	Missense_Mutation	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr5:140306523G>A	uc003lih.2	+	1	222	c.46G>A	c.(46-48)GGC>AGC	p.G16S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Intron|PCDHA13_uc003lif.2_Intron|PCDHAC1_uc003lig.1_Missense_Mutation_p.G16S	NM_018898	NP_061721	Q9H158	PCDC1_HUMAN	protocadherin alpha subfamily C, 1 isoform 1	16					homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGTTTCCTGCGGCGCTGCAGC	0.642000													5	47					0	0	0	0
PCDHGA4	56111	broad.mit.edu	37	5	140734878	140734878	+	Missense_Mutation	SNP	G	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr5:140734878G>T	uc003ljq.1	+	1	111	c.111G>T	c.(109-111)GAG>GAT	p.E37D	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljp.1_Missense_Mutation_p.E37D	NM_018917	NP_061740	Q9Y5G9	PCDG4_HUMAN	protocadherin gamma subfamily A, 4 isoform 1	37	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CGGTGTTTGAGGAGCAGGAAG	0.632000													10	80					7.48243e-07	3.57953e-06	1	0
HIST1H2BB	3018	broad.mit.edu	37	6	26043604	26043604	+	Silent	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr6:26043604C>T	uc003nfu.2	-	1	282	c.282G>A	c.(280-282)GAG>GAA	p.E94E	HIST1H3C_uc003nfv.2_5'Flank	NM_021062	NP_066406	P33778	H2B1B_HUMAN	histone cluster 1, H2bb	94					nucleosome assembly	nucleosome|nucleus	DNA binding				0						CCGTCTGAATCTCCCTGGAGG	0.562000													5	99					0	0	0	0
PPP1R10	5514	broad.mit.edu	37	6	30571943	30571943	+	Silent	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr6:30571943C>T	uc003nqn.1	-	14	1902	c.1350G>A	c.(1348-1350)CTG>CTA	p.L450L	PPP1R10_uc010jsc.1_Silent_p.L104L	NM_002714	NP_002705	Q96QC0	PP1RA_HUMAN	protein phosphatase 1, regulatory subunit 10	450	Essential for PPP1CA inhibition (By similarity).|Interaction with WDR82 (By similarity).				protein import into nucleus|transcription, DNA-dependent	PTW/PP1 phosphatase complex	DNA binding|protein phosphatase inhibitor activity|RNA binding|zinc ion binding			ovary(2)|lung(1)|kidney(1)	4						TATCATGGCTCAGACGCCGCG	0.562000													11	158					0	0	0	0
C4A	720	broad.mit.edu	37	6	31994872	31994872	+	Silent	SNP	C	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr6:31994872C>G	uc011dpd.1	+	20	2616	c.2565C>G	c.(2563-2565)CTC>CTG	p.L855L	C4A_uc011dpe.1_Silent_p.L855L	NM_007293	NP_009224	P0C0L4	CO4A_HUMAN	complement component 4A preproprotein	855					complement activation, classical pathway|inflammatory response|innate immune response	extracellular space	endopeptidase inhibitor activity				0						GGCCTGTCCTCTATAACTACC	0.632000													7	103					0	0	0	0
IP6K3	117283	broad.mit.edu	37	6	33693275	33693275	+	Missense_Mutation	SNP	C	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr6:33693275C>G	uc010jvf.2	-	6	1244	c.708G>C	c.(706-708)ATG>ATC	p.M236I	IP6K3_uc003ofb.2_Missense_Mutation_p.M236I	NM_001142883	NP_001136355	Q96PC2	IP6K3_HUMAN	inositol hexakisphosphate kinase 3	236					inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|protein phosphorylation	cytoplasm	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol hexakisphosphate 6-kinase activity|inositol trisphosphate 3-kinase activity				0						CACACTTCCTCATGTGGCGGG	0.632000													4	40					0	0	0	0
DAAM2	23500	broad.mit.edu	37	6	39843215	39843215	+	Silent	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr6:39843215G>A	uc003oow.2	+	11	1428	c.1272G>A	c.(1270-1272)GAG>GAA	p.E424E	DAAM2_uc010jxc.2_Silent_p.E424E|DAAM2_uc003oox.2_Silent_p.E424E	NM_015345	NP_056160	Q86T65	DAAM2_HUMAN	dishevelled associated activator of	424					actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)|skin(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					CTCCCTTGGAGAACTTCAATG	0.577000													11	79					0	0	0	0
CUL7	9820	broad.mit.edu	37	6	43006181	43006181	+	Missense_Mutation	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr6:43006181C>T	uc003otq.2	-	25	4900	c.4597G>A	c.(4597-4599)GAA>AAA	p.E1533K	CUL7_uc010jyg.2_Missense_Mutation_p.E812K|CUL7_uc011dvb.1_Missense_Mutation_p.E1617K|CUL7_uc010jyh.2_Missense_Mutation_p.E526K|KLC4_uc003otr.1_5'Flank	NM_014780	NP_055595	Q14999	CUL7_HUMAN	cullin 7	1533					interspecies interaction between organisms|ubiquitin-dependent protein catabolic process|vasculogenesis	anaphase-promoting complex|mitochondrion	ubiquitin protein ligase binding			ovary(3)|kidney(1)	4			all cancers(41;0.00231)|Colorectal(64;0.00237)|COAD - Colon adenocarcinoma(64;0.00473)|OV - Ovarian serous cystadenocarcinoma(102;0.0442)|KIRC - Kidney renal clear cell carcinoma(15;0.133)|Kidney(15;0.188)			GACCTGGGTTCCTTGCTGCCA	0.567000													4	62					0	0	0	0
SMAP1	60682	broad.mit.edu	37	6	71562302	71562302	+	Missense_Mutation	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr6:71562302G>A	uc003pfr.2	+	8	972	c.724G>A	c.(724-726)GAT>AAT	p.D242N	SMAP1_uc003pfs.2_Missense_Mutation_p.D215N|SMAP1_uc010kao.2_Missense_Mutation_p.D215N|SMAP1_uc010kap.2_Missense_Mutation_p.D232N	NM_001044305	NP_001037770	Q8IYB5	SMAP1_HUMAN	stromal membrane-associated GTPase-activating	242					regulation of ARF GTPase activity	plasma membrane	ARF GTPase activator activity|zinc ion binding				0						CCTGAACGATGATCTGGACAT	0.458000													10	134					0	0	0	0
C6orf204	387119	broad.mit.edu	37	6	118812872	118812872	+	Missense_Mutation	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr6:118812872C>T	uc003pxz.1	-	6	2002	c.1414G>A	c.(1414-1416)GAG>AAG	p.E472K	C6orf204_uc003pya.1_Missense_Mutation_p.E475K|C6orf204_uc003pyb.2_Missense_Mutation_p.E472K|C6orf204_uc011ebj.1_Missense_Mutation_p.E370K|C6orf204_uc003pyc.2_Missense_Mutation_p.E475K	NM_001042475	NP_001035940	Q5SZL2	CF204_HUMAN	chromosome 6 open reading frame 204 isoform a	472	Potential.					centrosome				breast(1)	1		all_cancers(87;0.0814)|all_epithelial(87;0.115)		GBM - Glioblastoma multiforme(226;0.0114)|all cancers(137;0.035)|OV - Ovarian serous cystadenocarcinoma(136;0.0618)		TTCTTCTTCTCTTCACTAAAT	0.338000													4	21					0	0	0	0
LAMA2	3908	broad.mit.edu	37	6	129419471	129419471	+	Missense_Mutation	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr6:129419471C>T	uc003qbn.2	+	4	655	c.550C>T	c.(550-552)CCC>TCC	p.P184S	LAMA2_uc003qbo.2_Missense_Mutation_p.P184S	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	184	Laminin N-terminal.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		CAATATTTATCCCCGCACTGG	0.448000													10	68					0	0	0	0
RAC1	5879	broad.mit.edu	37	7	6431563	6431563	+	Missense_Mutation	SNP	A	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr7:6431563A>G	uc003spx.2	+	3	357	c.116A>G	c.(115-117)AAT>AGT	p.N39S	RAC1_uc003spw.2_Missense_Mutation_p.N39S	NM_006908	NP_008839	P63000	RAC1_HUMAN	ras-related C3 botulinum toxin substrate 1	39	Effector region (Potential).				actin filament polymerization|apoptosis|axon guidance|cell motility|cell-matrix adhesion|induction of apoptosis by extracellular signals|inflammatory response|lamellipodium assembly|localization within membrane|negative regulation of interleukin-23 production|negative regulation of receptor-mediated endocytosis|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of lamellipodium assembly|positive regulation of Rho protein signal transduction|regulation of cell migration|regulation of defense response to virus by virus|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|ruffle organization|small GTPase mediated signal transduction|T cell costimulation|viral reproduction	cytosol|melanosome|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity|thioesterase binding			lung(2)	2		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.104)	Pravastatin(DB00175)|Simvastatin(DB00641)	AGCTTTGACAATTATTCTGCC	0.438000													4	64					0	0	0	0
RAC1	5879	broad.mit.edu	37	7	6441974	6441974	+	Missense_Mutation	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr7:6441974C>T	uc003spx.2	+	6	717	c.476C>T	c.(475-477)GCG>GTG	p.A159V	RAC1_uc003spw.2_Missense_Mutation_p.A178V	NM_006908	NP_008839	P63000	RAC1_HUMAN	ras-related C3 botulinum toxin substrate 1	159					actin filament polymerization|apoptosis|axon guidance|cell motility|cell-matrix adhesion|induction of apoptosis by extracellular signals|inflammatory response|lamellipodium assembly|localization within membrane|negative regulation of interleukin-23 production|negative regulation of receptor-mediated endocytosis|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of lamellipodium assembly|positive regulation of Rho protein signal transduction|regulation of cell migration|regulation of defense response to virus by virus|regulation of hydrogen peroxide metabolic process|regulation of respiratory burst|ruffle organization|small GTPase mediated signal transduction|T cell costimulation|viral reproduction	cytosol|melanosome|plasma membrane	GTP binding|GTP-dependent protein binding|GTPase activity|thioesterase binding			lung(2)	2		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.104)	Pravastatin(DB00175)|Simvastatin(DB00641)	GAGTGCTCGGCGCTCACACAG	0.567000													6	79					0	0	0	0
GLI3	2737	broad.mit.edu	37	7	42084994	42084994	+	Missense_Mutation	SNP	T	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr7:42084994T>A	uc011kbh.1	-	6	906	c.815A>T	c.(814-816)CAT>CTT	p.H272L	GLI3_uc011kbg.1_Missense_Mutation_p.H213L	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	272					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						ATCCATAGCATGAAGATATTC	0.502000									Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				23	217					0	0	0	0
DTX2	113878	broad.mit.edu	37	7	76109854	76109854	+	Missense_Mutation	SNP	G	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr7:76109854G>T	uc003uff.3	+	4	584	c.28G>T	c.(28-30)GTG>TTG	p.V10L	DTX2_uc011kgk.1_Intron|DTX2_uc003ufg.3_Missense_Mutation_p.V10L|DTX2_uc003ufh.3_Missense_Mutation_p.V10L|DTX2_uc003ufj.3_Missense_Mutation_p.V10L	NM_020892	NP_065943	Q86UW9	DTX2_HUMAN	deltex 2 isoform a	10	WWE 1.				Notch signaling pathway	cytoplasm|nucleus	protein binding|zinc ion binding			ovary(1)|skin(1)	2						CCCTTCCCTGGTGCAGGTGTA	0.657000													4	31					0.00024832	0.00115883	1	0
LOC100132832	100132832	broad.mit.edu	37	7	76681209	76681209	+	RNA	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr7:76681209G>C	uc003ufy.2	+	5		c.1186G>C				NR_028058				Homo sapiens cDNA FLJ59034 complete cds, moderately similar to Protein deltex-2.												0						GGAAGTGAGAGAGACAATGTC	0.453000													2	16					0	0	0	0
DMTF1	9988	broad.mit.edu	37	7	86815200	86815200	+	Missense_Mutation	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr7:86815200G>A	uc003uih.2	+	12	1431	c.1105G>A	c.(1105-1107)GAG>AAG	p.E369K	DMTF1_uc003uii.2_Missense_Mutation_p.E103K|DMTF1_uc003uij.2_Missense_Mutation_p.E103K|DMTF1_uc011khb.1_Missense_Mutation_p.E281K|DMTF1_uc003uik.2_RNA|DMTF1_uc003uil.2_Missense_Mutation_p.E369K|DMTF1_uc003uin.2_Missense_Mutation_p.E103K	NM_001142327	NP_001135799	Q9Y222	DMTF1_HUMAN	cyclin D binding myb-like transcription factor 1	369	Interaction with CCND1, CCND2 and CCND3 (By similarity).|Required for DNA-binding (By similarity).|Myb-like 2.				cell cycle	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Esophageal squamous(14;0.0058)					TCTGTTAGCTGAGGGATGGAG	0.393000													10	69					0	0	0	0
GIGYF1	64599	broad.mit.edu	37	7	100281196	100281196	+	Missense_Mutation	SNP	C	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr7:100281196C>G	uc003uwg.1	-	17	3038	c.2029G>C	c.(2029-2031)GAA>CAA	p.E677Q		NM_022574	NP_072096	O75420	PERQ1_HUMAN	PERQ amino acid rich, with GYF domain 1	677										large_intestine(1)|central_nervous_system(1)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					TGGAGTTGTTCTAGAATTGGA	0.612000													10	158					0	0	0	0
SRRT	51593	broad.mit.edu	37	7	100482943	100482943	+	Silent	SNP	C	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr7:100482943C>G	uc003uwy.2	+	11	1537	c.1269C>G	c.(1267-1269)CTC>CTG	p.L423L	SRRT_uc010lhl.1_Silent_p.L422L|SRRT_uc003uxa.2_Silent_p.L422L|SRRT_uc003uwz.2_Silent_p.L423L	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	423					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						CCTGCTCCCTCTTCATGCGCA	0.622000													6	61					0	0	0	0
SRRT	51593	broad.mit.edu	37	7	100483972	100483972	+	Missense_Mutation	SNP	C	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr7:100483972C>G	uc003uwy.2	+	14	1831	c.1563C>G	c.(1561-1563)ATC>ATG	p.I521M	SRRT_uc010lhl.1_Missense_Mutation_p.I520M|SRRT_uc003uxa.2_Missense_Mutation_p.I520M|SRRT_uc003uwz.2_Missense_Mutation_p.I521M	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	521					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						GCAACGACATCAAGCTGGCGG	0.617000													7	41					0	0	0	0
LHFPL3	375612	broad.mit.edu	37	7	104377175	104377175	+	Missense_Mutation	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr7:104377175G>A	uc003vce.2	+	2	623	c.499G>A	c.(499-501)GAA>AAA	p.E167K	LHFPL3_uc003vcf.2_Missense_Mutation_p.E167K	NM_199000	NP_945351	Q86UP9	LHPL3_HUMAN	lipoma HMGIC fusion partner-like 3	153						integral to membrane					0						GGACTCAGATGAAGTAAAACG	0.443000													5	33					0	0	0	0
MKRN1	23608	broad.mit.edu	37	7	140154936	140154936	+	Missense_Mutation	SNP	C	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr7:140154936C>G	uc003vvt.2	-	7	1420	c.1195G>C	c.(1195-1197)GAG>CAG	p.E399Q	MKRN1_uc003vvs.2_Missense_Mutation_p.E335Q|MKRN1_uc011krd.1_Missense_Mutation_p.E133Q	NM_013446	NP_038474	Q9UHC7	MKRN1_HUMAN	makorin ring finger protein 1 isoform 1	399							ligase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.00956)					CTCTGTGGCTCCTCTCTACGG	0.488000													12	158					0	0	0	0
INTS10	55174	broad.mit.edu	37	8	19683985	19683985	+	Missense_Mutation	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr8:19683985C>T	uc003wzj.2	+	9	1186	c.1055C>T	c.(1054-1056)TCG>TTG	p.S352L		NM_018142	NP_060612	Q9NVR2	INT10_HUMAN	integrator complex subunit 10	352					snRNA processing	integrator complex	protein binding			ovary(1)	1				Colorectal(111;0.057)|COAD - Colon adenocarcinoma(73;0.215)		GAAGATGTATCGAATGTGTAT	0.398000													13	101					0	0	0	0
NRG1	3084	broad.mit.edu	37	8	32621346	32621346	+	Missense_Mutation	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr8:32621346C>T	uc003xiv.2	+	12	1866	c.1349C>T	c.(1348-1350)TCG>TTG	p.S450L	NRG1_uc010lvo.2_3'UTR|NRG1_uc003xiu.2_Missense_Mutation_p.S455L|NRG1_uc003xiw.2_Missense_Mutation_p.S447L|NRG1_uc003xit.2_3'UTR|NRG1_uc010lvr.2_Missense_Mutation_p.S192L|NRG1_uc010lvs.2_Missense_Mutation_p.S192L|NRG1_uc010lvp.2_Missense_Mutation_p.S404L|NRG1_uc010lvq.2_Missense_Mutation_p.S387L|NRG1_uc011lbg.1_3'UTR|NRG1_uc011lbh.1_Missense_Mutation_p.S293L|NRG1_uc003xja.2_Missense_Mutation_p.S261L	NM_013964	NP_039258	Q02297	NRG1_HUMAN	neuregulin 1 isoform HRG-alpha	450	Cytoplasmic (Potential).				activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity				0		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		TCGCCCCCTTCGGAAATGTCT	0.562000													11	124					0	0	0	0
FAM135B	51059	broad.mit.edu	37	8	139164247	139164247	+	Missense_Mutation	SNP	C	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr8:139164247C>A	uc003yuy.2	-	13	2642	c.2471G>T	c.(2470-2472)GGA>GTA	p.G824V	FAM135B_uc003yux.2_Missense_Mutation_p.G725V|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.G386V|FAM135B_uc003yvb.2_Missense_Mutation_p.G386V	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	824										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			ATGGTCTGCTCCAGCATCTGT	0.507000										HNSCC(54;0.14)			7	76					1.12685e-05	5.36381e-05	1	0
TAF1L	138474	broad.mit.edu	37	9	32632475	32632475	+	Missense_Mutation	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr9:32632475C>T	uc003zrg.1	-	1	3193	c.3103G>A	c.(3103-3105)GAG>AAG	p.E1035K	uc003zrh.1_5'Flank	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	1035					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		TTTTTAATCTCTTCCTCAGGC	0.488000													22	234					0	0	0	0
TGFBR1	7046	broad.mit.edu	37	9	101910003	101910003	+	Missense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr9:101910003G>C	uc004azc.2	+	8	1399	c.1323G>C	c.(1321-1323)ATG>ATC	p.M441I	TGFBR1_uc004azd.2_Missense_Mutation_p.M364I|TGFBR1_uc011lvc.1_Missense_Mutation_p.M372I	NM_004612	NP_004603	P36897	TGFR1_HUMAN	transforming growth factor, beta receptor I	441	Protein kinase.|Cytoplasmic (Potential).				activation of MAPKK activity|anterior/posterior pattern formation|artery morphogenesis|collagen fibril organization|embryonic cranial skeleton morphogenesis|germ cell migration|heart development|kidney development|neuron fate commitment|palate development|parathyroid gland development|pathway-restricted SMAD protein phosphorylation|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|pharyngeal system development|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of cellular component movement|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of protein kinase B signaling cascade|positive regulation of SMAD protein import into nucleus|positive regulation of survival gene product expression|positive regulation of transcription, DNA-dependent|response to cholesterol|thymus development|transforming growth factor beta receptor signaling pathway		ATP binding|I-SMAD binding|metal ion binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type I|type II transforming growth factor beta receptor binding			lung(2)|ovary(1)	3		Acute lymphoblastic leukemia(62;0.0559)				TTGAAGAAATGAGAAAAGTTG	0.323000													7	55					0	0	0	0
IKBKAP	8518	broad.mit.edu	37	9	111670656	111670656	+	Silent	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr9:111670656C>T	uc004bdm.3	-	13	1909	c.1389G>A	c.(1387-1389)GTG>GTA	p.V463V	IKBKAP_uc004bdl.2_Silent_p.V114V|IKBKAP_uc011lwc.1_Silent_p.V349V|IKBKAP_uc010mtq.2_Silent_p.V114V	NM_003640	NP_003631	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene	463					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	7						CTCCCAGTTTCACTGTAGGGT	0.388000													4	45					0	0	0	0
TNFSF8	944	broad.mit.edu	37	9	117692466	117692466	+	Missense_Mutation	SNP	A	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr9:117692466A>G	uc004bji.1	-	1	305	c.118T>C	c.(118-120)TAT>CAT	p.Y40H		NM_001244	NP_001235	P32971	TNFL8_HUMAN	tumor necrosis factor (ligand) superfamily,	40	Helical; Signal-anchor for type II membrane protein; (Potential).				cell proliferation|cell-cell signaling|immune response|induction of apoptosis|signal transduction	extracellular space|integral to plasma membrane	cytokine activity|tumor necrosis factor receptor binding			lung(3)|skin(2)|ovary(1)	6						GTGGTCAAATAGAAATAGCTG	0.597000													13	114					0	0	0	0
METTL11A	28989	broad.mit.edu	37	9	132397708	132397708	+	Missense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr9:132397708G>C	uc004byd.1	+	4	831	c.637G>C	c.(637-639)GAG>CAG	p.E213Q	METTL11A_uc010myw.1_RNA|METTL11A_uc011mbs.1_3'UTR|ASB6_uc004bye.1_3'UTR|ASB6_uc004byf.1_3'UTR|ASB6_uc004byg.1_3'UTR|ASB6_uc011mbt.1_3'UTR|ASB6_uc010myx.1_3'UTR	NM_014064	NP_054783	Q9BV86	NTM1A_HUMAN	methyltransferase like 11A	213					chromosome segregation|N-terminal peptidyl-proline dimethylation|N-terminal peptidyl-serine dimethylation|N-terminal peptidyl-serine trimethylation|spindle organization	nucleus	protein binding|protein methyltransferase activity				0						CCTCCCCGATGAGATCTACCA	0.627000													7	119					0	0	0	0
GPR107	57720	broad.mit.edu	37	9	132854657	132854657	+	Missense_Mutation	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr9:132854657G>A	uc004bze.2	+	9	1087	c.860G>A	c.(859-861)CGA>CAA	p.R287Q	GPR107_uc004bzb.2_Missense_Mutation_p.R98Q|GPR107_uc004bzc.3_RNA|GPR107_uc011mbx.1_Missense_Mutation_p.R287Q|GPR107_uc004bzd.2_Missense_Mutation_p.R287Q	NM_001136557	NP_001130029	Q5VW38	GP107_HUMAN	G protein-coupled receptor 107 isoform 1	287						integral to membrane				upper_aerodigestive_tract(1)	1		Ovarian(14;0.000531)				CTTCGAAAACGACGGTAAACT	0.418000													6	71					0	0	0	0
GTF3C4	9329	broad.mit.edu	37	9	135554308	135554308	+	Missense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr9:135554308G>C	uc010mzv.2	+	2	1560	c.1302G>C	c.(1300-1302)CAG>CAC	p.Q434H	GTF3C4_uc010mzw.2_RNA	NM_012204	NP_036336	Q9UKN8	TF3C4_HUMAN	general transcription factor IIIC 4	434					transcription initiation from RNA polymerase III promoter	transcription factor TFIIIC complex	DNA binding|enzyme activator activity|histone acetyltransferase activity|protein binding			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(145;8.15e-07)|Epithelial(140;2.6e-05)		CAGACAAACAGAATGGAACAG	0.453000													4	102					0	0	0	0
NOTCH1	4851	broad.mit.edu	37	9	139412282	139412282	+	Missense_Mutation	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr9:139412282C>T	uc004chz.2	-	8	1363	c.1363G>A	c.(1363-1365)GAG>AAG	p.E455K		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	455	Extracellular (Potential).|EGF-like 12; calcium-binding (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GAGACGCACTCGTTGACGTCG	0.667000			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			15	51					0	0	0	0
FAM48B2	170067	broad.mit.edu	37	X	24330433	24330433	+	Missense_Mutation	SNP	C	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chrX:24330433C>G	uc011mjw.1	-	1	1000	c.1000G>C	c.(1000-1002)GAA>CAA	p.E334Q		NM_001136233	NP_001129705	P0C7V6	F48B2_HUMAN	family with sequence similarity 48, member B2	334											0						AAAGGGTCTTCTACCTCCTGG	0.537000													15	186					0	0	0	0
PHF16	9767	broad.mit.edu	37	X	46887308	46887308	+	Missense_Mutation	SNP	G	A	A			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chrX:46887308G>A	uc004dgx.2	+	6	541	c.490G>A	c.(490-492)GAT>AAT	p.D164N	PHF16_uc004dgy.2_Missense_Mutation_p.D164N	NM_001077445	NP_001070913	Q92613	JADE3_HUMAN	PHD finger protein 16	164					histone H3 acetylation|histone H4-K12 acetylation|histone H4-K5 acetylation|histone H4-K8 acetylation	histone acetyltransferase complex	zinc ion binding				0						TGGGCCAGTTGATGAGAATCT	0.458000													8	61					0	0	0	0
SPIN3	169981	broad.mit.edu	37	X	57020780	57020780	+	Missense_Mutation	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chrX:57020780C>T	uc010nkj.2	-	2	887	c.601G>A	c.(601-603)GAG>AAG	p.E201K	SPIN3_uc004duu.3_Intron|SPIN3_uc004duw.3_Intron|SPIN3_uc004duv.3_Intron|SPIN3_uc004dux.1_Missense_Mutation_p.E201K	NM_001010862	NP_001010862	Q5JUX0	SPIN3_HUMAN	spindlin family, member 3	201					gamete generation					ovary(1)|central_nervous_system(1)	2						TCTCCTGGCTCCCTCTCTGCC	0.463000													11	63					0	0	0	0
HEPH	9843	broad.mit.edu	37	X	65486458	65486458	+	Missense_Mutation	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chrX:65486458C>T	uc011moz.1	+	21	3490	c.3430C>T	c.(3430-3432)CGC>TGC	p.R1144C	HEPH_uc004dwn.2_Missense_Mutation_p.R1143C|HEPH_uc004dwo.2_Missense_Mutation_p.R874C|HEPH_uc010nkr.2_Missense_Mutation_p.R952C|HEPH_uc011mpa.1_Missense_Mutation_p.R1144C	NM_138737	NP_620074	Q9BQS7	HEPH_HUMAN	hephaestin isoform a	1141	Cytoplasmic (Potential).				cellular iron ion homeostasis|copper ion transport|transmembrane transport	integral to membrane|plasma membrane	copper ion binding|oxidoreductase activity			lung(5)|ovary(4)	9						AAAGCTACGACGCAATAGGAG	0.498000													5	48					0	0	0	0
XKRX	402415	broad.mit.edu	37	X	100177939	100177939	+	Silent	SNP	C	G	G			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chrX:100177939C>G	uc004egn.2	-	2	1052	c.447G>C	c.(445-447)CTG>CTC	p.L149L	XKRX_uc011mre.1_Intron	NM_212559	NP_997724	Q6PP77	XKR2_HUMAN	XK, Kell blood group complex subunit-related,	149						integral to membrane|plasma membrane				breast(1)	1						CCCATTCTATCAGCACCTCCT	0.547000													6	157					0	0	0	0
GRIA3	2892	broad.mit.edu	37	X	122551330	122551330	+	Missense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chrX:122551330G>C	uc004etq.3	+	12	1871	c.1578G>C	c.(1576-1578)ATG>ATC	p.M526I	GRIA3_uc004etr.3_Missense_Mutation_p.M526I|GRIA3_uc004ets.3_RNA|GRIA3_uc011muf.1_Missense_Mutation_p.M510I	NM_007325	NP_015564	P42263	GRIA3_HUMAN	glutamate receptor, ionotrophic, AMPA 3 isoform	526	Extracellular (Potential).				glutamate signaling pathway|synaptic transmission	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|cell junction|endocytic vesicle membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5					L-Glutamic Acid(DB00142)	AGCCATTCATGAGCCTGGGCA	0.398000													9	217					0	0	0	0
THOC2	57187	broad.mit.edu	37	X	122747943	122747943	+	Missense_Mutation	SNP	C	T	T			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chrX:122747943C>T	uc004etu.2	-	34	4441	c.4409G>A	c.(4408-4410)AGA>AAA	p.R1470K	THOC2_uc010nqt.1_RNA|THOC2_uc004etw.1_Missense_Mutation_p.R291K	NM_001081550	NP_001075019	Q8NI27	THOC2_HUMAN	THO complex 2	1470	Lys-rich.|Potential.				intronless viral mRNA export from host nucleus|mRNA processing|RNA splicing	THO complex part of transcription export complex	protein binding|RNA binding			ovary(3)	3						TTTTTTCTCTCTTTCTCTGGA	0.378000													8	111					0	0	0	0
MAGEC1	9947	broad.mit.edu	37	X	140993500	140993500	+	Missense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chrX:140993500G>C	uc004fbt.2	+	4	596	c.310G>C	c.(310-312)GAG>CAG	p.E104Q	MAGEC1_uc010nsl.1_Intron	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	104							protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					GAGTTCTCCTGAGGGGAAGGA	0.562000										HNSCC(15;0.026)			11	130					0	0	0	0
ABCD1	215	broad.mit.edu	37	X	153006171	153006171	+	Missense_Mutation	SNP	G	C	C			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chrX:153006171G>C	uc004fif.2	+	7	2177	c.1778G>C	c.(1777-1779)GGA>GCA	p.G593A	ABCD1_uc004fig.2_Missense_Mutation_p.G93A|ABCD1_uc004fih.2_5'Flank	NM_000033	NP_000024	P33897	ABCD1_HUMAN	ATP-binding cassette, sub-family D (ALD), member	593	ABC transporter.				fatty acid beta-oxidation using acyl-CoA oxidase|peroxisomal membrane transport|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|identical protein binding|peroxisomal fatty-acyl-CoA transporter activity				0	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CAGCGGGAGGGAGGTAGGAGG	0.612000													10	71					0	0	0	0
Unknown	0	broad.mit.edu	37	10	42528030	42528030	+	IGR	DEL	G	-	-			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr10:42528030delG								None (None upstream) : LOC441666 (299285 downstream)																							attatatgaagaaatcccgtt	0.000													---	---	---							
Unknown	0	broad.mit.edu	37	12	7338794	7338794	+	IGR	DEL	G	-	-	rs113717305		TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr12:7338794delG								CLSTN3 (27266 upstream) : PEX5 (2965 downstream)																							cctgttgagaggggggactga	0.000													---	---	---							
ADAM6	8755	broad.mit.edu	37	14	106919168	106919168	+	RNA	DEL	C	-	-			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr14:106919168delC	uc010tyt.1	-	245		c.10611delG			uc010tyu.1_Intron					Parts of antibodies, mostly variable regions.												0						ACGTTAACCTCCCCCTCACTG	0.557													---	---	---							
DDX52	11056	broad.mit.edu	37	17	36003614	36003614	+	5'Flank	DEL	T	-	-			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr17:36003614delT	uc002hoi.1	-						DDX52_uc002hoh.1_5'Flank|DDX52_uc002hoj.1_5'Flank	NM_007010	NP_008941	Q9Y2R4	DDX52_HUMAN	ATP-dependent RNA helicase ROK1 isoform a							nucleolus	ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|skin(1)	2		Breast(25;0.00637)|Ovarian(249;0.15)				ATTAtttatcttttttttttt	0.244													---	---	---							
Unknown	0	broad.mit.edu	37	19	56040963	56040969	+	IGR	DEL	AGAGAGG	-	-	rs71830799		TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr19:56040963_56040969delAGAGAGG								SSC5D (10498 upstream) : SBK2 (132 downstream)																							TGCAGCCTGCAGAGAGGAGAGAGGAGG	0.643													---	---	---							
Unknown	0	broad.mit.edu	37	21	20229947	20229948	+	IGR	INS	-	T	T	rs140136910	by1000genomes	TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr21:20229947_20229948insT								TMPRSS15 (453977 upstream) : None (None downstream)																							taagatctgcataaaaaaacaa	0.094													---	---	---							
NR3C1	2908	broad.mit.edu	37	5	142780167	142780178	+	In_Frame_Del	DEL	TGGACAGATCTG	-	-			TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr5:142780167_142780178delTGGACAGATCTG	uc003lmz.2	-	2	719_730	c.227_238delCAGATCTGTCCA	c.(226-240)CCAGATCTGTCCAAA>CAA	p.76_80PDLSK>Q	NR3C1_uc003lmy.2_In_Frame_Del_p.76_80PDLSK>Q|NR3C1_uc003lna.2_In_Frame_Del_p.76_80PDLSK>Q|NR3C1_uc003lnb.2_In_Frame_Del_p.76_80PDLSK>Q|NR3C1_uc011dbk.1_Intron|NR3C1_uc003lnc.2_In_Frame_Del_p.76_80PDLSK>Q|NR3C1_uc003lnd.2_In_Frame_Del_p.76_80PDLSK>Q|NR3C1_uc003lne.2_In_Frame_Del_p.76_80PDLSK>Q|NR3C1_uc003lnf.2_In_Frame_Del_p.76_80PDLSK>Q|NR3C1_uc003lng.2_In_Frame_Del_p.76_80PDLSK>Q|NR3C1_uc003lnh.2_In_Frame_Del_p.76_80PDLSK>Q|NR3C1_uc003lni.2_In_Frame_Del_p.76_80PDLSK>Q	NM_000176	NP_000167	P04150	GCR_HUMAN	glucocorticoid receptor isoform alpha	76_80	Modulating.				chromatin modification|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to protein stimulus|transcription from RNA polymerase II promoter	mitochondrial matrix|nucleoplasm	glucocorticoid receptor activity|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid binding|zinc ion binding			ovary(2)	2		Acute lymphoblastic leukemia(2;3.2e-05)|all_hematologic(2;0.000361)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)		Amcinonide(DB00288)|Betamethasone(DB00443)|Budesonide(DB01222)|Dexamethasone(DB01234)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluticasone Propionate(DB00588)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Loteprednol Etabonate(DB00873)|Methylprednisolone(DB00959)|Mifepristone(DB00834)|Mometasone(DB00764)|Prednisone(DB00635)	GAAACTGCTTTGGACAGATCTGGCTGCTGCGC	0.491													---	---	---							
Unknown	0	broad.mit.edu	37	9	68438424	68438425	+	IGR	DEL	TA	-	-	rs147494053		TCGA-CX-7085-01A-21D-2012-08	TCGA-CX-7085-10A-01D-2013-08									Somatic	Phase_I	Capture				Illumina GAIIx	4f6ee10b-246d-49cd-8b60-01dcb175e634	2daef6fc-3028-4843-a302-e38d33d7461f	g.chr9:68438424_68438425delTA								FAM27B (644235 upstream) : MIR1299 (563814 downstream)																							TTAAGGAATTTAAAAAAATGGA	0.337													---	---	---							
