Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
AGRN	375790	broad.mit.edu	37	1	979601	979601	+	Silent	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:979601C>G	uc001ack.1	+	11	2162	c.2112C>G	c.(2110-2112)GTC>GTG	p.V704V		NM_198576	NP_940978	O00468	AGRIN_HUMAN	agrin precursor	704	Kazal-like 8.				axon guidance|clustering of voltage-gated sodium channels|muscarinic acetylcholine receptor signaling pathway|receptor clustering	basal lamina	laminin binding|structural constituent of cytoskeleton			central_nervous_system(2)|breast(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		UCEC - Uterine corpus endometrioid carcinoma (11;0.00462)|Epithelial(90;5.98e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.43e-23)|Colorectal(212;5.97e-05)|COAD - Colon adenocarcinoma(227;0.000201)|Kidney(185;0.0024)|BRCA - Breast invasive adenocarcinoma(365;0.00246)|STAD - Stomach adenocarcinoma(132;0.00645)|KIRC - Kidney renal clear cell carcinoma(229;0.0354)|Lung(427;0.201)		GGCCGTGTGTCTGTGACTTCA	0.706		NaN											0	0	0	0.01892	0	24	33									
CDK11A	728642	broad.mit.edu	37	1	1636040	1636040	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:1636040C>T	uc009vks.2	-	14	1621	c.1513G>A	c.(1513-1515)GAG>AAG	p.E505K	CDK11B_uc001ags.1_Intron|CDK11B_uc001agt.1_Intron|CDK11B_uc001aha.1_Intron|CDK11B_uc001agw.1_Intron|CDK11B_uc001agv.1_Intron|CDK11B_uc001agy.1_Intron|CDK11B_uc001agx.1_Intron|CDK11B_uc001agz.1_Intron|SLC35E2B_uc001ahh.3_Intron|SLC35E2_uc009vkm.1_Intron|CDK11A_uc001ahj.3_Missense_Mutation_p.E12K|CDK11A_uc009vkp.2_Missense_Mutation_p.E122K|CDK11A_uc009vkq.2_RNA|CDK11A_uc009vkr.2_Missense_Mutation_p.E495K|CDK11A_uc010nys.1_Missense_Mutation_p.E495K|CDK11A_uc010nyt.1_3'UTR	NM_024011	NP_076916	Q9UQ88	CD11A_HUMAN	cell division cycle 2-like 2 isoform 1	508	Protein kinase.				apoptosis|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			stomach(1)	1						AGGTCGTGCTCCACGTAGTTC	0.617		NaN											0	0	0	0.004482	0	8	5									
CDK11A	728642	broad.mit.edu	37	1	1636274	1636274	+	Nonsense_Mutation	SNP	C	C	T	rs2179381	by1000genomes	TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:1636274C>T	uc010nyt.1	-	13	1635	c.1527G>A	c.(1525-1527)TGG>TGA	p.W509*	CDK11B_uc001ags.1_Intron|CDK11B_uc001agt.1_Intron|CDK11B_uc001aha.1_Intron|CDK11B_uc001agw.1_Intron|CDK11B_uc001agv.1_Intron|CDK11B_uc001agy.1_Intron|CDK11B_uc001agx.1_Intron|CDK11B_uc001agz.1_Intron|SLC35E2B_uc001ahh.3_Intron|SLC35E2_uc009vkm.1_Intron|CDK11A_uc001ahj.3_5'UTR|CDK11A_uc009vkp.2_Intron|CDK11A_uc009vkq.2_Intron|CDK11A_uc009vkr.2_Intron|CDK11A_uc009vks.2_Intron|CDK11A_uc010nys.1_Intron			Q9UQ88	CD11A_HUMAN	SubName: Full=cDNA FLJ56415, highly similar to PITSLRE serine/threonine-protein kinase CDC2L1 (EC 2.7.11.22);	Error:Variant_position_missing_in_Q9UQ88_after_alignment					apoptosis|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			stomach(1)	1						GCACCCGGCCCCAGGACAGCA	0.622		NaN											0	0	0	0.014758	0	5	24									
CDK11B	984	broad.mit.edu	37	1	1650892	1650892	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:1650892C>G	uc001agv.1	-	6	341	c.230G>C	c.(229-231)GGA>GCA	p.G77A	CDK11B_uc001ags.1_5'Flank|CDK11B_uc001agt.1_5'Flank|CDK11B_uc001aha.1_Missense_Mutation_p.G43A|CDK11B_uc001agw.1_Missense_Mutation_p.G43A|CDK11B_uc001agy.1_Missense_Mutation_p.G77A|CDK11B_uc001agx.1_Missense_Mutation_p.G77A|CDK11B_uc001agz.1_5'UTR|SLC35E2B_uc001ahh.3_Intron|SLC35E2_uc009vkm.1_Intron|CDK11A_uc009vkr.2_Missense_Mutation_p.G77A|CDK11A_uc009vks.2_Missense_Mutation_p.G77A|CDK11A_uc010nys.1_Missense_Mutation_p.G77A|CDK11A_uc010nyt.1_Missense_Mutation_p.G77A|CDK11A_uc010nyu.1_RNA|CDK11A_uc009vkt.1_Missense_Mutation_p.G77A|CDK11A_uc009vku.1_Missense_Mutation_p.G77A|CDK11A_uc009vkv.1_Missense_Mutation_p.G77A|CDK11A_uc001aht.1_Missense_Mutation_p.G77A|CDK11B_uc001ahu.1_Missense_Mutation_p.G77A|CDK11B_uc001ahv.1_Missense_Mutation_p.G77A|CDK11B_uc001ahw.1_Missense_Mutation_p.G77A	NM_033486	NP_277021	P21127	CD11B_HUMAN	cell division cycle 2-like 1 (PITSLRE proteins)	77					apoptosis|cell proliferation|mitosis|regulation of cell growth|regulation of mRNA processing|regulation of transcription, DNA-dependent	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity|protein binding			skin(1)	1						ATCTTCTTCTCCTCTGAAATA	0.388		NaN											0	0	0	0.00874	0	42	90									
ACTRT2	140625	broad.mit.edu	37	1	2938728	2938728	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:2938728G>A	uc001ajz.2	+	1	683	c.478G>A	c.(478-480)GGG>AGG	p.G160R		NM_080431	NP_536356	Q8TDY3	ACTT2_HUMAN	actin-related protein M2	160						cytoplasm|cytoskeleton					0	all_cancers(77;0.00205)|all_epithelial(69;0.0011)|Ovarian(185;0.0634)|Lung NSC(156;0.0893)|all_lung(157;0.0909)	all_epithelial(116;2.66e-20)|all_lung(118;1.56e-08)|Lung NSC(185;2.54e-06)|Breast(487;0.00156)|Renal(390;0.00183)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0308)|Lung SC(97;0.0847)|Medulloblastoma(700;0.123)		Epithelial(90;7.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;5.15e-22)|GBM - Glioblastoma multiforme(42;1.1e-12)|Colorectal(212;3.98e-05)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.000329)|BRCA - Breast invasive adenocarcinoma(365;0.000949)|KIRC - Kidney renal clear cell carcinoma(229;0.00544)|STAD - Stomach adenocarcinoma(132;0.00644)|Lung(427;0.125)		GGTGGACAGCGGGGATGCGGT	0.642		NaN											0	0	0	0.009096	0	4	46									
TP73	7161	broad.mit.edu	37	1	3649318	3649318	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:3649318G>C	uc001akp.2	+	14	1696	c.1586G>C	c.(1585-1587)GGG>GCG	p.G529A	TP73_uc001akq.2_Intron|TP73_uc001akr.2_Missense_Mutation_p.G480A|TP73_uc009vlk.1_3'UTR|TP73_uc001aks.2_Missense_Mutation_p.G449R|TP73_uc010nzk.1_Missense_Mutation_p.G458A|TP73_uc010nzl.1_Missense_Mutation_p.G78A	NM_005427	NP_005418	O15350	P73_HUMAN	tumor protein p73 isoform a	529	SAM.				cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mismatch repair|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of JUN kinase activity|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|protein tetramerization|response to gamma radiation|response to X-ray	chromatin|cytosol|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|metal ion binding|p53 binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding|transcription repressor activity			ovary(1)|lung(1)	2	all_cancers(77;0.0395)|Ovarian(185;0.0634)|Lung NSC(156;0.188)|all_lung(157;0.198)	all_epithelial(116;7.42e-17)|all_lung(118;1.86e-06)|Lung NSC(185;0.000163)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Lung SC(97;0.109)|Ovarian(437;0.127)		Epithelial(90;5.57e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.87e-22)|GBM - Glioblastoma multiforme(42;5.72e-16)|Colorectal(212;2.22e-05)|COAD - Colon adenocarcinoma(227;8.48e-05)|Kidney(185;0.000539)|BRCA - Breast invasive adenocarcinoma(365;0.000868)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.00751)|Lung(427;0.226)		CAGGACCTGGGGGCCCTGAAG	0.706		NaN											0	0	0	0.004672	0	3	20									
LOC440563	440563	broad.mit.edu	37	1	13183780	13183780	+	Silent	SNP	A	A	C	rs116484938	by1000genomes	TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:13183780A>C	uc010obg.1	-	1	188	c.93T>G	c.(91-93)TCT>TCG	p.S31S		NM_001136561	NP_001130033	B2RXH8	B2RXH8_HUMAN	heterogeneous nuclear ribonucleoprotein C-like	31						ribonucleoprotein complex	nucleic acid binding|nucleotide binding				0						CCTCCACATCAGATTTCTTGA	0.468		NaN											0	0	0	0.008291	0	5	63									
UQCRHL	440567	broad.mit.edu	37	1	16134162	16134162	+	Translation_Start_Site	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:16134162G>C	uc009vol.1	-	1	33	c.-17C>G	c.(-19--15)ATCTA>ATGTA			NM_001089591	NP_001083060			ubiquinol-cytochrome c reductase hinge												0						TACGGTTCTAGATTTAACACG	0.269		NaN											0	0	0	0.006214	0	10	20									
SLC30A2	7780	broad.mit.edu	37	1	26371526	26371526	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:26371526G>C	uc001blh.1	-	2	450	c.233C>G	c.(232-234)TCT>TGT	p.S78C	SLC30A2_uc001blg.1_Missense_Mutation_p.S78C	NM_032513	NP_115902	Q9BRI3	ZNT2_HUMAN	solute carrier family 30, member 2 isoform 2	78	Cytoplasmic (Potential).				positive regulation of sequestering of zinc ion|zinc ion transport	integral to membrane|late endosome|lysosomal membrane	cation transmembrane transporter activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;6.18e-05)|all_lung(284;9.43e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Breast(348;0.0155)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0298)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|OV - Ovarian serous cystadenocarcinoma(117;7.09e-26)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.000728)|BRCA - Breast invasive adenocarcinoma(304;0.000969)|STAD - Stomach adenocarcinoma(196;0.00151)|GBM - Glioblastoma multiforme(114;0.00614)|READ - Rectum adenocarcinoma(331;0.0649)		GCAGATGGCAGAGGCTACATA	0.527		NaN											0	0	0	0.00632	0	28	78									
PHACTR4	65979	broad.mit.edu	37	1	28817511	28817511	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:28817511G>C	uc001bpw.2	+	11	2147	c.1865G>C	c.(1864-1866)CGG>CCG	p.R622P	PHACTR4_uc001bpv.1_RNA|PHACTR4_uc001bpx.2_Missense_Mutation_p.R606P|PHACTR4_uc001bpy.2_Missense_Mutation_p.R632P|PHACTR4_uc001bpz.2_5'Flank	NM_001048183	NP_001041648	Q8IZ21	PHAR4_HUMAN	phosphatase and actin regulator 4 isoform 1	622	RPEL 3.						actin binding|protein phosphatase inhibitor activity				0		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;7.01e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;1.35e-21)|Colorectal(126;2.96e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00273)|STAD - Stomach adenocarcinoma(196;0.00299)|BRCA - Breast invasive adenocarcinoma(304;0.0144)|READ - Rectum adenocarcinoma(331;0.0649)		ATTAAACGTCGGCTCACTAGA	0.343		NaN											0	0	0	0.00308	0	8	25									
C1orf91	56063	broad.mit.edu	37	1	32687561	32687561	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:32687561C>T	uc009vub.1	-	2	78	c.75G>A	c.(73-75)CTG>CTA	p.L25L	C1orf91_uc001buo.3_RNA|C1orf91_uc001bup.3_RNA|C1orf91_uc010oha.1_RNA|C1orf91_uc001buq.3_Silent_p.L25L|EIF3I_uc001bur.3_5'UTR|EIF3I_uc009vuc.2_5'Flank|EIF3I_uc001bus.2_5'Flank			Q8WY98	TM234_HUMAN	RecName: Full=UPF0546 membrane protein C1orf91;	25						integral to membrane					0		Myeloproliferative disorder(586;0.0393)|all_neural(195;0.186)				AGGCCCGCTTCAGCAGCGGCT	0.642		NaN											0	0	0	0.010729	0	11	25									
KIAA0319L	79932	broad.mit.edu	37	1	35915552	35915552	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:35915552C>T	uc001byx.2	-	15	2527	c.2269G>A	c.(2269-2271)GAG>AAG	p.E757K	KIAA0319L_uc001byw.2_Missense_Mutation_p.E199K|KIAA0319L_uc010ohv.1_Missense_Mutation_p.E399K	NM_024874	NP_079150	Q8IZA0	K319L_HUMAN	dyslexia susceptibility 2-like	757	PKD 5.|Extracellular (Potential).					cytoplasmic vesicle part|integral to membrane	protein binding			skin(2)	2		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				TAGGTTCCCTCAACCAGGTTT	0.453		NaN											0	0	0	0.015359	0	35	43									
HIVEP3	59269	broad.mit.edu	37	1	41990541	41990541	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:41990541C>T	uc001cgz.3	-	6	6461	c.5248G>A	c.(5248-5250)GGC>AGC	p.G1750S	HIVEP3_uc001cha.3_Missense_Mutation_p.G1750S|HIVEP3_uc001cgy.2_Intron	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	1750					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				TTCCCTCGGCCGCGGCCTCGC	0.502		NaN											0	0	0	0.00499	0	18	34									
NEGR1	257194	broad.mit.edu	37	1	72400821	72400821	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:72400821G>A	uc001dfw.2	-	2	450	c.350C>T	c.(349-351)ACG>ATG	p.T117M	NEGR1_uc001dfv.2_Translation_Start_Site|NEGR1_uc010oqs.1_Missense_Mutation_p.T117M	NM_173808	NP_776169	Q7Z3B1	NEGR1_HUMAN	neuronal growth regulator 1 precursor	117	Ig-like C2-type 1.				cell adhesion	anchored to membrane|plasma membrane				ovary(1)	1		all_cancers(4;1.26e-06)|Renal(4;1.32e-08)|all_epithelial(4;5.39e-07)|Hepatocellular(141;0.117)		KIRC - Kidney renal clear cell carcinoma(4;0.00529)|Kidney(4;0.00609)|all cancers(265;0.022)|GBM - Glioblastoma multiforme(62;0.0382)|Epithelial(280;0.242)		AACAGAACACGTGTATGGGCC	0.418		NaN											0	0	0	0.024245	0	16	26									
TYW3	127253	broad.mit.edu	37	1	75204401	75204401	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:75204401G>A	uc001dgn.2	+	3	372	c.283G>A	c.(283-285)GAT>AAT	p.D95N	TYW3_uc010oqw.1_Intron|TYW3_uc010oqx.1_Intron|TYW3_uc010oqy.1_RNA	NM_138467	NP_612476	Q6IPR3	TYW3_HUMAN	tRNA-yW synthesizing protein 3 homolog isoform	95					tRNA processing		methyltransferase activity			ovary(2)	2						AGCAAATGGTGATGCCACTTT	0.378		NaN											0	0	0	0.004482	0	9	16									
GBP1	2633	broad.mit.edu	37	1	89528910	89528910	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:89528910G>A	uc001dmx.2	-	2	228	c.8C>T	c.(7-9)TCA>TTA	p.S3L		NM_002053	NP_002044	P32455	GBP1_HUMAN	guanylate binding protein 1,	3					interferon-gamma-mediated signaling pathway	plasma membrane	GTP binding|GTPase activity			ovary(1)|skin(1)	2		Lung NSC(277;0.123)		all cancers(265;0.0156)|Epithelial(280;0.0291)		GTGGATCTCTGATGCCATGTC	0.453		NaN											0	0	0	0.00632	0	28	60									
TRIM33	51592	broad.mit.edu	37	1	114940612	114940612	+	Missense_Mutation	SNP	T	T	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:114940612T>C	uc001eew.2	-	19	3205	c.3121A>G	c.(3121-3123)ATG>GTG	p.M1041V	TRIM33_uc010owr.1_Missense_Mutation_p.M655V|TRIM33_uc010ows.1_Missense_Mutation_p.M673V|TRIM33_uc001eex.2_Intron	NM_015906	NP_056990	Q9UPN9	TRI33_HUMAN	tripartite motif-containing 33 protein isoform	1041	Bromo.				negative regulation of BMP signaling pathway|negative regulation of transcription, DNA-dependent|protein ubiquitination|regulation of transforming growth factor beta receptor signaling pathway|transcription, DNA-dependent	nucleus	co-SMAD binding|DNA binding|ligase activity|R-SMAD binding|zinc ion binding			lung(4)|central_nervous_system(3)|large_intestine(1)|breast(1)|skin(1)|ovary(1)	11	all_epithelial(7;0.000132)|all_lung(7;0.00106)|Lung SC(450;0.184)	all_cancers(81;3.03e-08)|all_epithelial(167;3.24e-08)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACTTTCATCATCTAAAAAGGA	0.343		NaN	T	RET	papillary thyroid								0	0	0	0.010504	0	22	52									
NGF	4803	broad.mit.edu	37	1	115829160	115829160	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:115829160C>T	uc001efu.1	-	3	426	c.257G>A	c.(256-258)CGT>CAT	p.R86H		NM_002506	NP_002497	P01138	NGF_HUMAN	nerve growth factor, beta polypeptide precursor	86					activation of MAPKK activity|activation of phospholipase C activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|negative regulation of cell cycle|nerve growth factor processing|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|Golgi lumen	growth factor activity|nerve growth factor receptor binding			upper_aerodigestive_tract(2)	2	Lung SC(450;0.211)	all_cancers(81;1.07e-06)|all_epithelial(167;4.43e-06)|all_lung(203;2.86e-05)|Lung NSC(69;4.99e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)|all cancers(265;0.159)|Epithelial(280;0.179)	Clenbuterol(DB01407)	AAACAGCACACGGGGTGAACG	0.632		NaN											0	0	0	0.008291	0	11	30									
NOTCH2	4853	broad.mit.edu	37	1	120462189	120462189	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:120462189C>G	uc001eik.2	-	31	5783	c.5527G>C	c.(5527-5529)GAT>CAT	p.D1843H		NM_024408	NP_077719	Q04721	NOTC2_HUMAN	notch 2 preproprotein	1843	Cytoplasmic (Potential).|ANK 1.				anti-apoptosis|bone remodeling|cell cycle arrest|cell fate determination|cell growth|hemopoiesis|induction of apoptosis|negative regulation of cell proliferation|nervous system development|Notch receptor processing|Notch signaling pathway|organ morphogenesis|positive regulation of Ras protein signal transduction|regulation of transcription, DNA-dependent|stem cell maintenance|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|ligand-regulated transcription factor activity|protein binding|receptor activity			lung(8)|haematopoietic_and_lymphoid_tissue(7)|ovary(4)|central_nervous_system(2)|skin(2)|kidney(2)|breast(1)|prostate(1)	27	all_neural(166;0.153)	all_lung(203;1.96e-06)|Lung NSC(69;1.47e-05)|all_epithelial(167;0.000809)		Lung(183;0.0242)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCACTCAAATCTGAGCTGCCT	0.498		NaN	N|F|Mis		marginal zone lymphoma|DLBCL				Alagille_Syndrome				0	0	0	0.00308	0	7	14									
RPTN	126638	broad.mit.edu	37	1	152127966	152127966	+	Missense_Mutation	SNP	G	G	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:152127966G>T	uc001ezs.1	-	3	1674	c.1609C>A	c.(1609-1611)CAG>AAG	p.Q537K		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	537	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						CTGTCCATCTGACTGTAGTGG	0.532		NaN											1	0	4.53783e-81	0.01441	4.95855e-81	251	468									
OR6N2	81442	broad.mit.edu	37	1	158747279	158747279	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:158747279G>A	uc010pir.1	-	1	147	c.147C>T	c.(145-147)ATC>ATT	p.I49I		NM_001005278	NP_001005278	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N,	49	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(112;0.0378)					CATCCAGTCGGATGACTGAGA	0.483		NaN											0	0	0	0.01892	0	25	77									
FCRLB	127943	broad.mit.edu	37	1	161697272	161697272	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:161697272G>A	uc001gbh.2	+	8	1335	c.1101G>A	c.(1099-1101)CTG>CTA	p.L367L	FCRLB_uc009wus.2_Silent_p.L367L|FCRLB_uc001gbj.2_Silent_p.*319*|FCRLB_uc001gbk.2_3'UTR|FCRLB_uc001gbl.2_Silent_p.*312*|FCRLB_uc001gbm.2_3'UTR|FCRLB_uc001gbi.2_Silent_p.L367L|FCRLB_uc001gbn.3_3'UTR	NM_001002901	NP_001002901	Q6BAA4	FCRLB_HUMAN	Fc receptor-like B	367						endoplasmic reticulum					0	all_hematologic(112;0.0359)		BRCA - Breast invasive adenocarcinoma(70;0.00634)			CTGGAGCCCTGAAACCCGACG	0.682		NaN											0	0	0	0.00499	0	16	29									
MAEL	84944	broad.mit.edu	37	1	166959001	166959001	+	Missense_Mutation	SNP	T	T	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:166959001T>C	uc001gdy.1	+	2	231	c.160T>C	c.(160-162)TAC>CAC	p.Y54H	MAEL_uc001gdz.1_Intron|MAEL_uc009wvf.1_5'Flank	NM_032858	NP_116247	Q96JY0	MAEL_HUMAN	maelstrom homolog	54	HMG box.				cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			skin(1)	1						AAAGGAGAAATACGCAGAAAT	0.532		NaN											0	0	0	0.021553	0	5	8									
C1orf125	126859	broad.mit.edu	37	1	179399689	179399689	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:179399689G>C	uc001gmo.2	+	14	1562	c.1435G>C	c.(1435-1437)GAG>CAG	p.E479Q	C1orf125_uc009wxg.2_RNA|C1orf125_uc001gmn.1_Missense_Mutation_p.E267Q|C1orf125_uc010pnl.1_RNA|C1orf125_uc001gmp.2_Missense_Mutation_p.E479Q	NM_144696	NP_653297	Q5T1B0	AXDN1_HUMAN	hypothetical protein LOC126859 isoform 1	479	Potential.										0						GTCTACAAGCGAGACACTGAA	0.368		NaN											0	0	0	0.00499	0	18	47									
LHX4	89884	broad.mit.edu	37	1	180243439	180243439	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:180243439C>G	uc001goe.1	+	6	1121	c.898C>G	c.(898-900)CAG>GAG	p.Q300E	uc001gof.1_Intron	NM_033343	NP_203129	Q969G2	LHX4_HUMAN	LIM homeobox protein 4	300						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						ACAATCCTATCAGGACTTGAG	0.542		NaN											0	0	0	0.025465	0	40	81									
RGL1	23179	broad.mit.edu	37	1	183895257	183895257	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:183895257C>T	uc001gqo.2	+	18	2295	c.2138C>T	c.(2137-2139)TCA>TTA	p.S713L	RGL1_uc001gqm.2_Missense_Mutation_p.S748L|RGL1_uc010pog.1_Missense_Mutation_p.S711L|RGL1_uc010poh.1_Missense_Mutation_p.S711L|RGL1_uc010poi.1_Missense_Mutation_p.S684L	NM_015149	NP_055964	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation	713	Ras-associating.				cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|ovary(4)|lung(2)	11						ATTCCAGACTCAGCAAATGTC	0.443		NaN											0	0	0	0.016723	0	14	47									
PTGS2	5743	broad.mit.edu	37	1	186643532	186643532	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:186643532C>T	uc001gsb.2	-	10	1905	c.1768G>A	c.(1768-1770)GAT>AAT	p.D590N	PTGS2_uc009wyo.2_Missense_Mutation_p.D437N	NM_000963	NP_000954	P35354	PGH2_HUMAN	prostaglandin-endoperoxide synthase 2 precursor	590					cellular component movement|cyclooxygenase pathway|hormone biosynthetic process|positive regulation of brown fat cell differentiation|positive regulation of cell migration involved in sprouting angiogenesis|positive regulation of fever generation|positive regulation of fibroblast growth factor production|positive regulation of nitric oxide biosynthetic process|positive regulation of platelet-derived growth factor production|positive regulation of prostaglandin biosynthetic process|positive regulation of transforming growth factor-beta production|positive regulation vascular endothelial growth factor production|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|microsome|neuron projection|nucleus	enzyme binding|heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|central_nervous_system(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Carprofen(DB00821)|Celecoxib(DB00482)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Epoprostenol(DB01240)|Etodolac(DB00749)|Etoricoxib(DB01628)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ginseng(DB01404)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lenalidomide(DB00480)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Meloxicam(DB00814)|Mesalazine(DB00244)|Nabumetone(DB00461)|Naproxen(DB00788)|Oxaprozin(DB00991)|Phenylbutazone(DB00812)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Thalidomide(DB01041)|Tiaprofenic acid(DB01600)|Tolmetin(DB00500)|Valdecoxib(DB00580)	GGATTGATATCATCTAGTCCG	0.368		NaN											0	0	0	0.01892	0	26	52									
FAM58B	339521	broad.mit.edu	37	1	200183226	200183226	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:200183226C>T	uc009wzi.1	+	1	571	c.535C>T	c.(535-537)CGG>TGG	p.R179W		NM_001105517	NP_001098987	P0C7Q3	FA58B_HUMAN	family with sequence similarity 58 member B	179					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent		protein kinase binding				0	Prostate(682;0.19)					GGCCCTGCTGCGGGACAGCTA	0.637		NaN											0	0	0	0.006214	0	10	37									
SPATA17	128153	broad.mit.edu	37	1	217804728	217804728	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:217804728C>G	uc001hlh.1	+	1	34	c.8C>G	c.(7-9)ACG>AGG	p.T3R	GPATCH2_uc001hlf.1_5'Flank|SPATA17_uc009xdr.1_RNA|SPATA17_uc001hli.2_Missense_Mutation_p.T3R|GPATCH2_uc001hlg.3_5'Flank	NM_138796	NP_620151	Q96L03	SPT17_HUMAN	spermatogenesis associated 17	3						cytoplasm	calmodulin binding			pancreas(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0516)|all cancers(67;0.0891)|GBM - Glioblastoma multiforme(131;0.117)		ACCATGGCCACGTTAGCCCGG	0.527		NaN											0	0	0	0.014758	0	5	20									
PCNXL2	80003	broad.mit.edu	37	1	233363102	233363102	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:233363102G>C	uc001hvl.2	-	10	2609	c.2374C>G	c.(2374-2376)CTG>GTG	p.L792V	PCNXL2_uc009xfu.2_Intron|PCNXL2_uc009xfv.1_Intron|PCNXL2_uc001hvq.1_Missense_Mutation_p.L91V	NM_014801	NP_055616	A6NKB5	PCX2_HUMAN	pecanex-like 2	792						integral to membrane				central_nervous_system(1)|pancreas(1)	2		all_cancers(173;0.0347)|Prostate(94;0.137)				GAGGCTTCCAGATCCTGACTC	0.343		NaN											0	0	0	0.020292	0	15	20									
OR2M7	391196	broad.mit.edu	37	1	248487244	248487244	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:248487244G>A	uc010pzk.1	-	1	627	c.627C>T	c.(625-627)TTC>TTT	p.F209F		NM_001004691	NP_001004691	Q8NG81	OR2M7_HUMAN	olfactory receptor, family 2, subfamily M,	209	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TTGCAACAGGGAAAACAAGCA	0.418		NaN											0	0	0	0.01441	0	87	201									
CELF2	10659	broad.mit.edu	37	10	11367804	11367804	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:11367804G>C	uc001iki.3	+	12	1353	c.1261G>C	c.(1261-1263)GAG>CAG	p.E421Q	CELF2_uc010qbj.1_Missense_Mutation_p.E427Q|CELF2_uc001ikk.2_Missense_Mutation_p.E446Q|CELF2_uc001ikl.3_Missense_Mutation_p.E434Q|CELF2_uc010qbl.1_Missense_Mutation_p.E397Q|CELF2_uc010qbm.1_Missense_Mutation_p.E193Q|CELF2_uc001iko.3_Missense_Mutation_p.E401Q|CELF2_uc001ikp.3_Missense_Mutation_p.E403Q|CELF2_uc010qbn.1_Missense_Mutation_p.E409Q|CELF2_uc010qbo.1_Missense_Mutation_p.E316Q|CELF2_uc010qbp.1_Missense_Mutation_p.E193Q	NM_001025077	NP_001020248	O95319	CELF2_HUMAN	CUG triplet repeat, RNA binding protein 2	421	Necessary for RNA-binding, TNNT2 exon 5 and NMDA R1 exon 21 inclusion.				mRNA processing|regulation of heart contraction	cytoplasm|nucleus	nucleotide binding|protein binding|RNA binding				0						CTTAGGTCCAGAGGGGGCAAA	0.418		NaN											0	0	0	0.008291	0	11	36									
TRDMT1	1787	broad.mit.edu	37	10	17216603	17216603	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:17216603C>T	uc001iop.2	-	2	169	c.121G>A	c.(121-123)GAA>AAA	p.E41K	TRDMT1_uc001ioq.2_Missense_Mutation_p.E41K|TRDMT1_uc001ior.2_Missense_Mutation_p.E41K|TRDMT1_uc001ios.2_5'UTR|TRDMT1_uc009xjt.2_Missense_Mutation_p.M7I|TRDMT1_uc010qcd.1_Missense_Mutation_p.E41K|TRDMT1_uc009xjs.1_Missense_Mutation_p.M7I|TRDMT1_uc009xju.1_RNA	NM_004412	NP_004403	O14717	TRDMT_HUMAN	tRNA aspartic acid methyltransferase 1 isoform	41					tRNA processing	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|RNA binding			ovary(1)	1						TTGTATACTTCATTAGCGACA	0.363		NaN											0	0	0	0.024245	0	16	47									
ANKRD26	22852	broad.mit.edu	37	10	27332447	27332447	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:27332447G>A	uc001ith.2	-	20	2238	c.2066C>T	c.(2065-2067)TCA>TTA	p.S689L	ANKRD26_uc001itg.2_Missense_Mutation_p.S376L|ANKRD26_uc009xku.1_Missense_Mutation_p.S690L	NM_014915	NP_055730	Q9UPS8	ANR26_HUMAN	ankyrin repeat domain 26	689						centrosome				large_intestine(1)|haematopoietic_and_lymphoid_tissue(1)|ovary(1)|skin(1)	4						TGTTTCAGATGACTGAGTTAA	0.373		NaN											0	0	0	0.008291	0	11	12									
SVIL	6840	broad.mit.edu	37	10	29776225	29776225	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:29776225C>G	uc001iut.1	-	24	5105	c.4352G>C	c.(4351-4353)AGA>ACA	p.R1451T	LOC387647_uc001iuq.1_RNA|SVIL_uc010qdw.1_Missense_Mutation_p.R365T|SVIL_uc001iuu.1_Missense_Mutation_p.R1025T|SVIL_uc009xlc.2_Missense_Mutation_p.R243T	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	1451	Gelsolin-like 1.|Interaction with NEB.				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				CACATGTCTTCTTCCTGAACA	0.582		NaN											0	0	0	0.006214	0	9	23									
MAP3K8	1326	broad.mit.edu	37	10	30727904	30727904	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:30727904G>C	uc001ivi.1	+	3	733	c.37G>C	c.(37-39)GAG>CAG	p.E13Q	MAP3K8_uc009xlf.1_Missense_Mutation_p.E13Q|MAP3K8_uc001ivj.1_Missense_Mutation_p.E13Q	NM_005204	NP_005195	P41279	M3K8_HUMAN	mitogen-activated protein kinase kinase kinase	13					cell cycle|T cell costimulation	cytosol	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			breast(3)|central_nervous_system(1)	4		Prostate(175;0.151)				CAATAAAGAAGAGATTGATTT	0.323		NaN											0	0	0	0.001984	0	7	15									
MAP3K8	1326	broad.mit.edu	37	10	30727994	30727994	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:30727994G>C	uc001ivi.1	+	3	823	c.127G>C	c.(127-129)GAA>CAA	p.E43Q	MAP3K8_uc009xlf.1_Missense_Mutation_p.E43Q|MAP3K8_uc001ivj.1_Missense_Mutation_p.E43Q	NM_005204	NP_005195	P41279	M3K8_HUMAN	mitogen-activated protein kinase kinase kinase	43					cell cycle|T cell costimulation	cytosol	ATP binding|magnesium ion binding|MAP kinase kinase kinase activity|protein binding			breast(3)|central_nervous_system(1)	4		Prostate(175;0.151)				AGCAGTTTATGAACCCAGTCT	0.363		NaN											0	0	0	0.016723	0	14	40									
BMS1	9790	broad.mit.edu	37	10	43292616	43292616	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:43292616G>C	uc001jaj.2	+	10	2282	c.1924G>C	c.(1924-1926)GAA>CAA	p.E642Q		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	642					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3						CAGTGATATAGAAAATTTACT	0.373		NaN											0	0	0	0.008871	0	13	38									
BMS1	9790	broad.mit.edu	37	10	43292652	43292652	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:43292652G>C	uc001jaj.2	+	10	2318	c.1960G>C	c.(1960-1962)GAA>CAA	p.E654Q		NM_014753	NP_055568	Q14692	BMS1_HUMAN	BMS1-like, ribosome assembly protein	654					ribosome assembly	nucleolus	ATP binding|GTP binding|GTPase activity			ovary(2)|upper_aerodigestive_tract(1)	3						TTACAAGGAAGAAAATAATGA	0.383		NaN											0	0	0	0.013537	0	5	37									
GDF2	2658	broad.mit.edu	37	10	48413880	48413880	+	Missense_Mutation	SNP	T	T	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:48413880T>A	uc001jfa.1	-	2	1151	c.988A>T	c.(988-990)ACC>TCC	p.T330S		NM_016204	NP_057288	Q9UK05	GDF2_HUMAN	growth differentiation factor 2 precursor	330					activin receptor signaling pathway|BMP signaling pathway|cartilage development|cellular iron ion homeostasis|growth|negative regulation of angiogenesis|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of DNA replication|negative regulation of endothelial cell proliferation|ossification|pathway-restricted SMAD protein phosphorylation|patterning of blood vessels|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity	p.T330I(1)		ovary(2)|skin(1)	3						CGCAGGGAGGTCTTTTGACAG	0.607		NaN											0	0	0	0.016522	0	24	36									
ANK3	288	broad.mit.edu	37	10	61830481	61830481	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:61830481C>T	uc001jky.2	-	37	10350	c.10158G>A	c.(10156-10158)GGG>GGA	p.G3386G	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	3386					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						GGTCGTTGTTCCCATTCTGGG	0.468		NaN											0	0	0	0.015359	0	36	67									
ANK3	288	broad.mit.edu	37	10	61831191	61831191	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:61831191C>G	uc001jky.2	-	37	9640	c.9448G>C	c.(9448-9450)GAT>CAT	p.D3150H	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	3150					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						AGAGTATCATCTTCTGGACTA	0.428		NaN											0	0	0	0.00632	0	30	72									
ZMIZ1	57178	broad.mit.edu	37	10	81037044	81037044	+	Silent	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:81037044C>G	uc001kaf.2	+	8	959	c.387C>G	c.(385-387)CTC>CTG	p.L129L	ZMIZ1_uc001kag.2_Silent_p.L5L|ZMIZ1_uc001kah.1_Silent_p.L5L	NM_020338	NP_065071	Q9ULJ6	ZMIZ1_HUMAN	retinoic acid induced 17	129					transcription, DNA-dependent	cytoplasm|nuclear speck	zinc ion binding			ovary(2)|breast(1)|skin(1)	4	all_cancers(46;0.0292)|Breast(12;8.52e-05)|all_epithelial(25;0.000854)|Prostate(51;0.00985)		Epithelial(14;0.00256)|all cancers(16;0.00726)|Colorectal(32;0.229)			AGCCCCCTCTCAGCTCCATGA	0.622		NaN											0	0	0	0.004672	0	3	28									
ARL3	403	broad.mit.edu	37	10	104459170	104459170	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:104459170C>G	uc001kwa.2	-	3	382	c.224G>C	c.(223-225)AGA>ACA	p.R75T		NM_004311	NP_004302	P36405	ARL3_HUMAN	ADP-ribosylation factor-like 3	75					cell cycle|cytokinesis|small GTPase mediated signal transduction	centrosome|cytoplasmic microtubule|Golgi membrane|midbody|nucleus|photoreceptor connecting cilium|spindle microtubule	GDP binding|GTP binding|metal ion binding|microtubule binding				0		Colorectal(252;0.122)		Epithelial(162;4.88e-09)|all cancers(201;1.29e-07)|BRCA - Breast invasive adenocarcinoma(275;0.22)		CCAGTATGGTCTGATTTTCCT	0.358		NaN											0	0	0	0.021553	0	6	8									
TACC2	10579	broad.mit.edu	37	10	123903125	123903125	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr10:123903125C>T	uc001lfv.2	+	7	6098	c.5738C>T	c.(5737-5739)TCG>TTG	p.S1913L	TACC2_uc001lfw.2_Intron|TACC2_uc009xzx.2_Intron|TACC2_uc010qtv.1_Intron|TACC2_uc001lfx.2_Intron|TACC2_uc001lfy.2_Intron	NM_206862	NP_996744	O95359	TACC2_HUMAN	transforming, acidic coiled-coil containing	1913						microtubule organizing center|nucleus	nuclear hormone receptor binding			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10		all_neural(114;0.0656)|Lung NSC(174;0.136)|all_lung(145;0.17)|Breast(234;0.197)				CTTCCTCCCTCGGCTGCAGAA	0.562		NaN									OREG0020589	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.008291	0	10	40									
MUC6	4588	broad.mit.edu	37	11	1026380	1026380	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:1026380G>A	uc001lsw.2	-	20	2544	c.2493C>T	c.(2491-2493)TTC>TTT	p.F831F		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	831					maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AGACCCCCGAGAACTCACATG	0.647		NaN											0	0	0	0.021553	0	6	11									
DCHS1	8642	broad.mit.edu	37	11	6643190	6643190	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:6643190G>A	uc001mem.1	-	21	10127	c.9717C>T	c.(9715-9717)ATC>ATT	p.I3239I	TPP1_uc001mek.1_5'Flank|TPP1_uc001mel.1_5'Flank|TPP1_uc010rar.1_5'Flank	NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	3239	Cytoplasmic (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTTCATGGCTGATGGGGGAGC	0.642		NaN											0	0	0	0.00308	0	7	6									
CSRP3	8048	broad.mit.edu	37	11	19209781	19209781	+	Silent	SNP	G	G	A	rs34075817		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:19209781G>A	uc001mpk.2	-	3	300	c.183C>T	c.(181-183)TGC>TGT	p.C61C		NM_003476	NP_003467	P50461	CSRP3_HUMAN	cysteine and glycine-rich protein 3	61	LIM zinc-binding 1.				cell differentiation|skeletal muscle tissue development	cytoskeleton|nucleus	protein binding|zinc ion binding				0						TGCGCCCATAGCACACCTTGC	0.587		NaN											0	0	0	0.01892	0	25	48									
DCDC1	341019	broad.mit.edu	37	11	31327862	31327862	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:31327862G>C	uc001msv.2	-	5	710	c.508C>G	c.(508-510)CAA>GAA	p.Q170E	DCDC1_uc001msu.1_5'UTR	NM_181807	NP_861523	P59894	DCDC1_HUMAN	doublecortin domain containing 1	170	Doublecortin.				intracellular signal transduction					skin(1)	1	Lung SC(675;0.225)					ACTCTTGGTTGAAGTTTGTGT	0.368		NaN											0	0	0	0.007413	0	20	25									
TNKS1BP1	85456	broad.mit.edu	37	11	57076206	57076206	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:57076206C>G	uc001njr.2	-	5	4291	c.3979G>C	c.(3979-3981)GAC>CAC	p.D1327H	TNKS1BP1_uc001njs.2_Missense_Mutation_p.D1327H|TNKS1BP1_uc009ymd.1_Missense_Mutation_p.D778H	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	1327	Gly-rich.|Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				CCTCCAGAGTCTGGGTCACAG	0.607		NaN											0	0	0	0.01441	0	56	100									
PRPF19	27339	broad.mit.edu	37	11	60671234	60671234	+	Missense_Mutation	SNP	T	T	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:60671234T>C	uc001nqf.2	-	2	326	c.119A>G	c.(118-120)GAC>GGC	p.D40G		NM_014502	NP_055317	Q9UMS4	PRP19_HUMAN	PRP19/PSO4 pre-mRNA processing factor 19	40	U-box.				DNA repair|protein polyubiquitination|spliceosome assembly	catalytic step 2 spliceosome|nuclear speck|spindle|ubiquitin ligase complex	DNA binding|identical protein binding|ubiquitin-ubiquitin ligase activity			ovary(1)	1						GTTGATGGGGTCGGTACCATT	0.532		NaN											0	0	0	0.014323	0	22	42									
TMEM216	51259	broad.mit.edu	37	11	61161357	61161357	+	Silent	SNP	T	T	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:61161357T>G	uc010rlj.1	+	3	410	c.117T>G	c.(115-117)GGT>GGG	p.G39G	TMEM216_uc001nrn.1_5'UTR	NM_016499	NP_057583	Q9P0N5	TM216_HUMAN	transmembrane protein 216	39						integral to membrane					0						TATTGGCAGGTGTCCTGCTAC	0.438		NaN											0	0	0	0.006214	0	6	20									
MARK2	2011	broad.mit.edu	37	11	63666131	63666131	+	Missense_Mutation	SNP	A	A	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:63666131A>T	uc001nxw.2	+	5	968	c.389A>T	c.(388-390)GAG>GTG	p.E130V	MARK2_uc001nxx.2_Missense_Mutation_p.E130V|MARK2_uc001nxy.2_Missense_Mutation_p.E130V|MARK2_uc001nxv.3_Missense_Mutation_p.E130V|MARK2_uc001nxz.3_Missense_Mutation_p.E97V|MARK2_uc009yoy.2_Missense_Mutation_p.E97V	NM_001039469	NP_001034558	Q7KZI7	MARK2_HUMAN	MAP/microtubule affinity-regulating kinase 2	130	Protein kinase.				cell differentiation|establishment or maintenance of epithelial cell apical/basal polarity|intracellular protein kinase cascade|multicellular organismal development|response to oxidative stress	plasma membrane	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)|ovary(1)|lung(1)	3						CTTGTCATGGAGTACGCTAGT	0.498		NaN											0	0	0	0.027356	0	26	45									
FERMT3	83706	broad.mit.edu	37	11	63978782	63978782	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:63978782C>T	uc001nyl.2	+	5	699	c.550C>T	c.(550-552)CAC>TAC	p.H184Y	FERMT3_uc001nym.2_Missense_Mutation_p.H184Y	NM_178443	NP_848537	Q86UX7	URP2_HUMAN	fermitin family homolog 3 long form	184					integrin activation|leukocyte cell-cell adhesion|platelet aggregation|regulation of cell-cell adhesion mediated by integrin	cell junction|cell projection|podosome	integrin binding			ovary(1)	1						GATGCCAGCTCACTTCTCGGA	0.706		NaN											0	0	0	0.013537	0	11	9									
MEN1	4221	broad.mit.edu	37	11	64575138	64575138	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:64575138C>T	uc001obj.2	-	4	757	c.684G>A	c.(682-684)CTG>CTA	p.L228L	MEN1_uc001obk.2_Silent_p.L228L|MEN1_uc001obl.2_Silent_p.L188L|MEN1_uc001obm.2_Silent_p.L223L|MEN1_uc001obn.2_Silent_p.L228L|MEN1_uc001obo.2_Silent_p.L228L|MEN1_uc001obp.2_Silent_p.L223L|MEN1_uc001obq.2_Silent_p.L228L|MEN1_uc001obr.2_Silent_p.L228L	NM_130800	NP_570712	O00255	MEN1_HUMAN	menin isoform 1	228	Interaction with FANCD2.		L -> P (in MEN1).		DNA repair|histone lysine methylation|MAPKKK cascade|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of JNK cascade|negative regulation of osteoblast differentiation|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of telomerase activity|negative regulation of transcription from RNA polymerase II promoter|osteoblast development|positive regulation of protein binding|positive regulation of transforming growth factor beta receptor signaling pathway|response to gamma radiation|response to UV|transcription, DNA-dependent	chromatin|cleavage furrow|cytosol|histone methyltransferase complex|nuclear matrix|soluble fraction	double-stranded DNA binding|four-way junction DNA binding|protein binding, bridging|protein N-terminus binding|R-SMAD binding|transcription regulatory region DNA binding|Y-form DNA binding			parathyroid(105)|pancreas(64)|gastrointestinal_tract_(site_indeterminate)(15)|small_intestine(13)|lung(9)|pituitary(7)|NS(7)|adrenal_gland(5)|soft_tissue(4)|central_nervous_system(4)|thymus(2)|stomach(1)|retroperitoneum(1)|skin(1)	238						ATGATCCTTTCAGGTACAGCC	0.552		NaN	D|Mis|N|F|S		parathyroid tumors|Pancreatic neuroendocrine tumors	parathyroid adenoma|pituitary adenoma|pancreatic islet cell|carcinoid			Hyperparathyroidism_Familial_Isolated|Multiple_Endocrine_Neoplasia_type_1				0	0	0	0.01892	0	23	22									
DPP3	10072	broad.mit.edu	37	11	66259013	66259013	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:66259013G>A	uc001oig.1	+	8	909	c.847G>A	c.(847-849)GAG>AAG	p.E283K	DPP3_uc001oif.1_Missense_Mutation_p.E283K|DPP3_uc010rpe.1_Missense_Mutation_p.E272K	NM_005700	NP_005691	Q9NY33	DPP3_HUMAN	dipeptidyl peptidase III	283					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			ovary(1)|skin(1)	2						CCAGTATATAGAGAGCTTCAC	0.657		NaN									OREG0021109	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00499	0	16	25									
ADRBK1	156	broad.mit.edu	37	11	67052379	67052379	+	Missense_Mutation	SNP	C	C	G	rs1051181		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:67052379C>G	uc009yrn.1	+	19	1982	c.1716C>G	c.(1714-1716)TTC>TTG	p.F572L	ADRBK1_uc009yrm.1_Intron	NM_001619	NP_001610	P25098	ARBK1_HUMAN	beta-adrenergic receptor kinase 1	572	PH.				activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	alpha-2A adrenergic receptor binding|ATP binding|beta-adrenergic receptor kinase activity|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|signal transducer activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)	GCAACCCCTTCCTGACCCAGT	0.667		NaN											0	0	0	0.010729	0	12	22									
SYTL2	54843	broad.mit.edu	37	11	85445049	85445049	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:85445049G>C	uc010rth.1	-	6	1596	c.1320C>G	c.(1318-1320)ATC>ATG	p.I440M	SYTL2_uc010rtg.1_Missense_Mutation_p.I441M|SYTL2_uc010rti.1_Missense_Mutation_p.I440M|SYTL2_uc010rtj.1_Missense_Mutation_p.I392M|SYTL2_uc001pbf.3_Missense_Mutation_p.I440M|SYTL2_uc010rtf.1_Missense_Mutation_p.I298M	NM_001162951	NP_001156423	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2 isoform g	440					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			ovary(2)|large_intestine(1)	3		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		TGGGTTCATTGATGGTTGGTG	0.383		NaN											0	0	0	0.00632	0	30	64									
SYTL2	54843	broad.mit.edu	37	11	85445395	85445395	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:85445395G>C	uc010rth.1	-	6	1250	c.974C>G	c.(973-975)TCC>TGC	p.S325C	SYTL2_uc010rtg.1_Missense_Mutation_p.S326C|SYTL2_uc010rti.1_Missense_Mutation_p.S325C|SYTL2_uc010rtj.1_Missense_Mutation_p.S277C|SYTL2_uc001pbf.3_Missense_Mutation_p.S325C|SYTL2_uc010rtf.1_Missense_Mutation_p.S183C	NM_001162951	NP_001156423	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2 isoform g	325					intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			ovary(2)|large_intestine(1)	3		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		TGGCTCCAGGGAGTTTGGGGA	0.448		NaN											0	0	0	0.009535	0	32	74									
OR8D2	283160	broad.mit.edu	37	11	124189263	124189263	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:124189263G>A	uc010sah.1	-	1	831	c.831C>T	c.(829-831)TTC>TTT	p.F277F		NM_001002918	NP_001002918	Q9GZM6	OR8D2_HUMAN	olfactory receptor, family 8, subfamily D,	277	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)|central_nervous_system(1)|pancreas(1)	3		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0525)		TTGTGATGTAGAACACAGAAG	0.423		NaN											0	0	0	0.013726	0	33	54									
KCNJ1	3758	broad.mit.edu	37	11	128709677	128709677	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr11:128709677G>C	uc001qeo.1	-	2	570	c.519C>G	c.(517-519)TTC>TTG	p.F173L	KCNJ1_uc001qep.1_Missense_Mutation_p.F154L|KCNJ1_uc001qeq.1_Missense_Mutation_p.F154L|KCNJ1_uc001qer.1_Missense_Mutation_p.F154L|KCNJ1_uc001qes.1_Missense_Mutation_p.F154L	NM_000220	NP_000211	P48048	IRK1_HUMAN	potassium inwardly-rectifying channel J1 isoform	173	Helical; Name=M2; (By similarity).				excretion	voltage-gated potassium channel complex	ATP binding|inward rectifier potassium channel activity			ovary(3)|breast(1)	4	all_hematologic(175;0.0641)	all_lung(97;4.89e-06)|Lung NSC(97;9.34e-06)|Breast(109;0.00123)|all_hematologic(192;0.00793)|Renal(330;0.0112)|all_neural(223;0.0189)|Medulloblastoma(222;0.0425)		OV - Ovarian serous cystadenocarcinoma(99;4.05e-06)|LUSC - Lung squamous cell carcinoma(976;0.008)|Lung(977;0.00942)	Acetohexamide(DB00414)|Chlorpropamide(DB00672)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Glimepiride(DB00222)|Glipizide(DB01067)|Glycodiazine(DB01382)|Minoxidil(DB00350)|Nateglinide(DB00731)|Repaglinide(DB00912)|Tolazamide(DB00839)|Tolbutamide(DB01124)	CCCCACACATGAAAGAATTGA	0.458		NaN											0	0	0	0.019004	0	36	51									
CHD4	1108	broad.mit.edu	37	12	6700750	6700750	+	Splice_Site	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:6700750C>T	uc001qpo.2	-	22	3387	c.3223_splice	c.e22-1	p.M1075_splice	CHD4_uc001qpn.2_Splice_Site_p.M1068_splice|CHD4_uc001qpp.2_Splice_Site_p.M1072_splice	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4						chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						TCTTGGTCATCTGCAAAAGAA	0.453		NaN											0	0	0	0.01441	0	67	89									
DENND5B	160518	broad.mit.edu	37	12	31605240	31605240	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:31605240C>G	uc001rki.1	-	5	1449	c.1263G>C	c.(1261-1263)AAG>AAC	p.K421N	DENND5B_uc001rkh.1_Missense_Mutation_p.K456N|DENND5B_uc009zjq.1_Missense_Mutation_p.K340N|DENND5B_uc001rkj.2_Missense_Mutation_p.K443N|DENND5B_uc001rkk.1_Missense_Mutation_p.K343N	NM_144973	NP_659410	Q6ZUT9	DEN5B_HUMAN	DENN/MADD domain containing 5B	421						integral to membrane				ovary(1)|central_nervous_system(1)	2						GAACCATATTCTTCAGTTTGC	0.408		NaN											0	0	0	0.012213	0	31	52									
LRRK2	120892	broad.mit.edu	37	12	40699617	40699617	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:40699617C>T	uc001rmg.3	+	28	3929	c.3808C>T	c.(3808-3810)CTG>TTG	p.L1270L	LRRK2_uc009zjw.2_Silent_p.L108L|LRRK2_uc001rmi.2_Silent_p.L103L	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1270	LRR 12.				activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				TCTTGAAAATCTGACATCTCT	0.403		NaN											0	0	0	0.008871	0	20	32									
MLL2	8085	broad.mit.edu	37	12	49434621	49434621	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:49434621G>A	uc001rta.3	-	31	6932	c.6932C>T	c.(6931-6933)TCC>TTC	p.S2311F		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2311	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GGTGCCTGAGGAGGGTGAGTC	0.612		NaN	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.024245	0	16	23									
SMARCC2	6601	broad.mit.edu	37	12	56563943	56563943	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:56563943C>G	uc001skb.2	-	22	2410	c.2304G>C	c.(2302-2304)GAG>GAC	p.E768D	SMARCC2_uc001skd.2_Missense_Mutation_p.E799D|SMARCC2_uc001ska.2_Missense_Mutation_p.E799D|SMARCC2_uc001skc.2_Missense_Mutation_p.E798D|SMARCC2_uc010sqf.1_Missense_Mutation_p.E688D	NM_003075	NP_003066	Q8TAQ2	SMRC2_HUMAN	SWI/SNF-related matrix-associated	768	Glu-rich.				chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			lung(2)|central_nervous_system(2)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(18;0.123)			GCTCCTTCTTCTCATCTGTGG	0.537		NaN											0	0	0	0.013537	0	11	26									
SLC39A5	283375	broad.mit.edu	37	12	56629471	56629471	+	Missense_Mutation	SNP	G	G	C	rs145666015		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:56629471G>C	uc010sqj.1	+	8	1189	c.932G>C	c.(931-933)CGA>CCA	p.R311P	SLC39A5_uc010sqi.1_Missense_Mutation_p.R202P|SLC39A5_uc010sqk.1_Missense_Mutation_p.R311P	NM_173596	NP_775867	Q6ZMH5	S39A5_HUMAN	solute carrier family 39 (metal ion	311	Cytoplasmic (Potential).				zinc ion transport	basolateral plasma membrane|integral to membrane	metal ion transmembrane transporter activity			ovary(1)|skin(1)	2						TTGCGGCACCGAGGGCTCAGG	0.532		NaN											0	0	0	0.023175	0	41	86									
TMEM194A	23306	broad.mit.edu	37	12	57472433	57472433	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:57472433C>G	uc001smy.2	-	1	142	c.96G>C	c.(94-96)TTG>TTC	p.L32F	TMEM194A_uc001smx.2_Missense_Mutation_p.L32F|TMEM194A_uc010sra.1_5'UTR	NM_001130963	NP_001124435	O14524	T194A_HUMAN	transmembrane protein 194A isoform a	32	Helical; (Potential).					integral to membrane					0						CGGAGAGGATCAAGAGTAGCC	0.657		NaN											0	0	0	0.00499	0	15	35									
LRP1	4035	broad.mit.edu	37	12	57550665	57550665	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:57550665C>G	uc001snd.2	+	10	1989	c.1523C>G	c.(1522-1524)TCC>TGC	p.S508C		NM_002332	NP_002323	Q07954	LRP1_HUMAN	low density lipoprotein-related protein 1	508	EGF-like 3.|Extracellular (Potential).				aorta morphogenesis|apoptotic cell clearance|negative regulation of platelet-derived growth factor receptor-beta signaling pathway|negative regulation of smooth muscle cell migration|negative regulation of Wnt receptor signaling pathway|positive regulation of cholesterol efflux|regulation of actin cytoskeleton organization|regulation of phospholipase A2 activity	coated pit|integral to plasma membrane|nucleus	apolipoprotein E binding|calcium ion binding|lipoprotein transporter activity|protein complex binding|receptor activity			ovary(8)|lung(3)|breast(3)|large_intestine(2)|central_nervous_system(2)|skin(2)|pancreas(2)	22				BRCA - Breast invasive adenocarcinoma(357;0.0103)	Alteplase(DB00009)|Anistreplase(DB00029)|Antihemophilic Factor(DB00025)|Becaplermin(DB00102)|Coagulation Factor IX(DB00100)|Tenecteplase(DB00031)	CGCTGCCGTTCCGGCTTCAGC	0.632		NaN											0	0	0	0.021553	0	5	13									
TBK1	29110	broad.mit.edu	37	12	64882283	64882283	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:64882283G>A	uc001ssc.1	+	12	1419	c.1357G>A	c.(1357-1359)GAT>AAT	p.D453N		NM_013254	NP_037386	Q9UHD2	TBK1_HUMAN	TANK-binding kinase 1	453					I-kappaB kinase/NF-kappaB cascade|innate immune response|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of transcription from RNA polymerase II promoter|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(2)|ovary(1)|large_intestine(1)|breast(1)	5				GBM - Glioblastoma multiforme(28;0.0386)		AATTAAAGATGATTACAATGA	0.269		NaN											0	0	0	0.00308	0	7	8									
RPL6	6128	broad.mit.edu	37	12	112843711	112843711	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:112843711C>T	uc001ttu.2	-	6	889	c.660G>A	c.(658-660)AAG>AAA	p.K220K	RPL6_uc001ttv.2_Silent_p.K220K	NM_001024662	NP_001019833	Q02878	RL6_HUMAN	ribosomal protein L6	220					endocrine pancreas development|regulation of transcription, DNA-dependent|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit	DNA binding|RNA binding|structural constituent of ribosome			large_intestine(1)	1						TCCGCAGCTTCTTCTTCTTGA	0.423		NaN											0	0	0	0.028581	0	16	31									
TMEM120B	144404	broad.mit.edu	37	12	122199641	122199641	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:122199641C>G	uc001ubc.3	+	6	692	c.548C>G	c.(547-549)TCA>TGA	p.S183*	TMEM120B_uc009zxh.2_Nonsense_Mutation_p.S183*	NM_001080825	NP_001074294	A0PK00	T120B_HUMAN	transmembrane protein 120B	183						integral to membrane					0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)			OV - Ovarian serous cystadenocarcinoma(86;5.75e-05)|Epithelial(86;0.000128)|BRCA - Breast invasive adenocarcinoma(302;0.238)		AGCAACGGCTCAAGGTACCTG	0.557		NaN											0	0	0	0.020292	0	14	31									
ZCCHC8	55596	broad.mit.edu	37	12	122962400	122962400	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:122962400C>G	uc001ucn.2	-	13	1464	c.1333G>C	c.(1333-1335)GAG>CAG	p.E445Q	ZCCHC8_uc001ucl.2_Missense_Mutation_p.E56Q|ZCCHC8_uc001ucm.2_Missense_Mutation_p.E207Q|ZCCHC8_uc009zxp.2_Missense_Mutation_p.E207Q|ZCCHC8_uc009zxq.2_Missense_Mutation_p.E207Q	NM_017612	NP_060082	Q6NZY4	ZCHC8_HUMAN	zinc finger, CCHC domain containing 8	445						catalytic step 2 spliceosome	nucleic acid binding|protein binding|zinc ion binding				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.25e-05)|Epithelial(86;0.000113)|BRCA - Breast invasive adenocarcinoma(302;0.202)		GAATCGAGCTCCATGTCGGCG	0.343		NaN											0	0	0	0.006214	0	10	14									
NCOR2	9612	broad.mit.edu	37	12	124821437	124821437	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:124821437G>A	uc010tay.1	-	40	6163	c.6007C>T	c.(6007-6009)CGC>TGC	p.R2003C	NCOR2_uc010taz.1_Missense_Mutation_p.R1987C|NCOR2_uc010tax.1_Missense_Mutation_p.R114C	NM_006312	NP_006303	Q9Y618	NCOR2_HUMAN	nuclear receptor co-repressor 2 isoform 1	2004					cellular lipid metabolic process|negative regulation of transcription from RNA polymerase II promoter|regulation of cellular ketone metabolic process by negative regulation of transcription from an RNA polymerase II promoter|transcription, DNA-dependent	nuclear body|nucleus|transcriptional repressor complex	DNA binding|histone deacetylase binding|Notch binding|protein N-terminus binding|transcription corepressor activity			skin(3)|ovary(1)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.163)			Epithelial(86;3.99e-05)|OV - Ovarian serous cystadenocarcinoma(86;9.14e-05)|all cancers(50;0.000402)|BRCA - Breast invasive adenocarcinoma(302;0.0764)		GCAGGGGTGCGGGCGATGGTG	0.731		NaN											0	0	0	0.00308	0	8	13									
EP400	57634	broad.mit.edu	37	12	132547093	132547093	+	Silent	SNP	A	A	G	rs28513925	by1000genomes	TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr12:132547093A>G	uc001ujn.2	+	46	8216	c.8181A>G	c.(8179-8181)CAA>CAG	p.Q2727Q	EP400_uc001ujl.2_Silent_p.Q2726Q|EP400_uc001ujm.2_Silent_p.Q2646Q|EP400_uc001ujp.2_5'UTR	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2763	Poly-Gln.|Interaction with ZNF42 (By similarity).				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		agcagcaacaacagcagcagc	0.294		NaN											0	0	0	0.021553	0	6	36									
ZMYM5	9205	broad.mit.edu	37	13	20411884	20411884	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr13:20411884G>A	uc010tcn.1	-	6	1215	c.950C>T	c.(949-951)TCT>TTT	p.S317F	ZMYM5_uc001umm.1_Missense_Mutation_p.S141F|ZMYM5_uc001umn.2_Missense_Mutation_p.S317F|ZMYM5_uc001umo.2_3'UTR	NM_001142684	NP_001136156	Q9UJ78	ZMYM5_HUMAN	zinc finger protein 237 isoform 3	317	MYM-type 2.					nucleus	zinc ion binding				0		all_cancers(29;2.96e-22)|all_epithelial(30;3.76e-20)|all_lung(29;4.38e-20)|Lung NSC(5;5.8e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.61e-05)|Epithelial(112;4.89e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00171)|Lung(94;0.00942)|LUSC - Lung squamous cell carcinoma(192;0.0431)		AGACAAACAAGATGTACTATA	0.338		NaN											0	0	0	0.010729	0	10	48									
AKAP11	11215	broad.mit.edu	37	13	42874879	42874879	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr13:42874879C>T	uc001uys.1	+	8	2172	c.1997C>T	c.(1996-1998)TCA>TTA	p.S666L		NM_016248	NP_057332	Q9UKA4	AKA11_HUMAN	A-kinase anchor protein 11	666					intracellular protein kinase cascade	microtubule organizing center	protein kinase A binding|protein phosphatase 1 binding			ovary(1)|central_nervous_system(1)	2		Lung NSC(96;1.86e-05)|Prostate(109;0.0165)|Lung SC(185;0.0262)|Breast(139;0.0707)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;0.000365)|GBM - Glioblastoma multiforme(144;0.00116)|BRCA - Breast invasive adenocarcinoma(63;0.19)		TGTCAGTTTTCATATCCTCAA	0.403		NaN											0	0	0	0.00632	0	29	78									
MLNR	2862	broad.mit.edu	37	13	49796426	49796426	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr13:49796426G>A	uc010tgj.1	+	2	1152	c.1152G>A	c.(1150-1152)AGG>AGA	p.R384R		NM_001507	NP_001498	O43193	MTLR_HUMAN	motilin receptor	384	Cytoplasmic (Potential).				digestion	integral to plasma membrane	growth hormone-releasing hormone receptor activity				0		all_lung(13;8.31e-06)|Lung NSC(96;0.000251)|Breast(56;0.0008)|Prostate(109;0.00446)|Hepatocellular(98;0.0556)|Glioma(44;0.236)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;6.1e-09)		ACAGAAGCAGGGACACTGCGG	0.567		NaN											0	0	0	0.00499	0	18	39									
RAP2A	5911	broad.mit.edu	37	13	98116619	98116619	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr13:98116619G>A	uc001vnd.2	+	2	725	c.475G>A	c.(475-477)GAA>AAA	p.E159K		NM_021033	NP_066361	P10114	RAP2A_HUMAN	RAP2A, member of RAS oncogene family precursor	159					actin cytoskeleton reorganization|cellular protein localization|establishment of protein localization|positive regulation of protein autophosphorylation|Rap protein signal transduction|regulation of dendrite morphogenesis|regulation of JNK cascade	recycling endosome membrane	GTP binding|GTPase activity|protein binding			central_nervous_system(1)	1	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.166)			ACTCTTTGCAGAAATTGTGAG	0.478		NaN											0	0	0	0.027356	0	28	86									
MYH7	4625	broad.mit.edu	37	14	23884449	23884449	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr14:23884449C>G	uc001wjx.2	-	37	5420	c.5314G>C	c.(5314-5316)GAG>CAG	p.E1772Q		NM_000257	NP_000248	P12883	MYH7_HUMAN	myosin, heavy chain 7, cardiac muscle, beta	1772	Potential.				adult heart development|muscle filament sliding|regulation of heart rate|ventricular cardiac muscle tissue morphogenesis	focal adhesion|muscle myosin complex|myosin filament|nucleus|sarcomere	actin binding|actin-dependent ATPase activity|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(3)|skin(1)	4	all_cancers(95;2.54e-05)			GBM - Glioblastoma multiforme(265;0.00725)		GTGTCCTGCTCCTTCTTCAGC	0.602		NaN											0	0	0	0.021523	0	23	71									
NFATC4	4776	broad.mit.edu	37	14	24843541	24843541	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr14:24843541C>T	uc001wpc.2	+	6	2063	c.1742C>T	c.(1741-1743)TCA>TTA	p.S581L	NFATC4_uc010tok.1_Missense_Mutation_p.S644L|NFATC4_uc010tol.1_Missense_Mutation_p.S644L|NFATC4_uc010alr.2_Missense_Mutation_p.S644L|NFATC4_uc010als.2_3'UTR|NFATC4_uc010tom.1_Missense_Mutation_p.S594L|NFATC4_uc010ton.1_Missense_Mutation_p.S594L|NFATC4_uc010too.1_Missense_Mutation_p.S594L|NFATC4_uc010alt.2_Missense_Mutation_p.S613L|NFATC4_uc010top.1_Missense_Mutation_p.S613L|NFATC4_uc010toq.1_Missense_Mutation_p.S613L|NFATC4_uc010alu.2_3'UTR|NFATC4_uc010tor.1_Missense_Mutation_p.S581L|NFATC4_uc010tos.1_Missense_Mutation_p.S511L|NFATC4_uc010tot.1_Missense_Mutation_p.S569L|NFATC4_uc010tou.1_Missense_Mutation_p.S511L|NFATC4_uc010tov.1_Missense_Mutation_p.S569L|NFATC4_uc010tow.1_Missense_Mutation_p.S511L|NFATC4_uc010alv.2_Missense_Mutation_p.S569L|NFATC4_uc010tox.1_Missense_Mutation_p.S511L|NFATC4_uc001wpd.2_Missense_Mutation_p.S116L|NFATC4_uc010toy.1_Missense_Mutation_p.S116L|NFATC4_uc010toz.1_Missense_Mutation_p.S116L|NFATC4_uc010tpa.1_5'UTR|NFATC4_uc010tpb.1_5'UTR	NM_004554	NP_004545	Q14934	NFAC4_HUMAN	nuclear factor of activated T-cells,	581	RHD.				cell differentiation|inflammatory response|transcription from RNA polymerase II promoter	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(265;0.018)		GCCCAGCGCTCAGCCCAGGAG	0.642		NaN											0	0	0	0.001984	0	6	13									
HECTD1	25831	broad.mit.edu	37	14	31613367	31613367	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr14:31613367C>G	uc001wrc.1	-	17	3217	c.2728G>C	c.(2728-2730)GAA>CAA	p.E910Q	HECTD1_uc001wrd.1_Missense_Mutation_p.E425Q	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	910					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		CTACACATTTCATATGGTGAA	0.303		NaN											0	0	0	0.004482	0	8	16									
MIPOL1	145282	broad.mit.edu	37	14	37892073	37892073	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr14:37892073C>G	uc001wuc.2	+	12	1453	c.950C>G	c.(949-951)TCT>TGT	p.S317C	MIPOL1_uc010amr.2_RNA|MIPOL1_uc001wub.3_Missense_Mutation_p.S286C|MIPOL1_uc001wud.2_Missense_Mutation_p.S317C|MIPOL1_uc010ams.2_Missense_Mutation_p.S317C|MIPOL1_uc001wue.2_Missense_Mutation_p.S286C|MIPOL1_uc010amt.2_Missense_Mutation_p.S136C	NM_138731	NP_620059	Q8TD10	MIPO1_HUMAN	mirror-image polydactyly 1	317	Potential.									ovary(1)|central_nervous_system(1)	2	Breast(36;0.119)|Esophageal squamous(585;0.164)|Hepatocellular(127;0.213)		Lung(238;6.03e-07)|LUAD - Lung adenocarcinoma(48;2.48e-05)|Epithelial(34;0.047)|all cancers(34;0.0953)|LUSC - Lung squamous cell carcinoma(13;0.0975)|BRCA - Breast invasive adenocarcinoma(188;0.196)	GBM - Glioblastoma multiforme(112;0.0358)		AAGTTGTTATCTATGCAACAA	0.323		NaN											0	0	0	0.004672	0	3	12									
PNN	5411	broad.mit.edu	37	14	39644553	39644553	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr14:39644553G>A	uc001wuw.3	+	1	167	c.70G>A	c.(70-72)GAG>AAG	p.E24K		NM_002687	NP_002678	Q9H307	PININ_HUMAN	pinin, desmosome associated protein	24	Potential.|Necessary for interaction with RNPS1.|Necessary for mediating alternative 5' splicing.|Necessary for interactions with KRT8, KRT18 and KRT19.				cell adhesion|regulation of transcription, DNA-dependent|transcription, DNA-dependent	catalytic step 2 spliceosome|desmosome|intermediate filament|nuclear speck	DNA binding|protein binding|structural molecule activity			ovary(1)	1	Hepatocellular(127;0.213)		LUAD - Lung adenocarcinoma(48;0.000565)|Lung(238;0.000711)	GBM - Glioblastoma multiforme(112;0.0119)		GAACGTGGATGAGAACATTCG	0.577		NaN											0	0	0	0.021553	0	5	20									
SLC38A6	145389	broad.mit.edu	37	14	61517300	61517300	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr14:61517300G>A	uc001xfg.1	+	13	1112	c.996G>A	c.(994-996)GTG>GTA	p.V332V	SLC38A6_uc001xfh.1_Silent_p.V332V|SLC38A6_uc001xfi.2_RNA|SLC38A6_uc001xfj.1_RNA|SLC38A6_uc001xfk.2_RNA|SLC38A6_uc010trz.1_Silent_p.V309V	NM_153811	NP_722518	Q8IZM9	S38A6_HUMAN	solute carrier family 38, member 6	332	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3				OV - Ovarian serous cystadenocarcinoma(108;0.0981)		TCATGACTGTGAAGTTATGCA	0.343		NaN											0	0	0	0.010729	0	11	23									
SYNE2	23224	broad.mit.edu	37	14	64449432	64449432	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr14:64449432G>C	uc001xgm.2	+	17	2151	c.1921G>C	c.(1921-1923)GAT>CAT	p.D641H	SYNE2_uc001xgl.2_Missense_Mutation_p.D641H	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	641	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		AGTCAGCAATGATGTGGTTGG	0.373		NaN											0	0	0	0.008361	0	30	43									
KCNK10	54207	broad.mit.edu	37	14	88693731	88693731	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr14:88693731C>T	uc001xwo.2	-	4	1111	c.654G>A	c.(652-654)GAG>GAA	p.E218E	KCNK10_uc001xwm.2_Silent_p.E223E|KCNK10_uc001xwn.2_Silent_p.E223E	NM_021161	NP_066984	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	218	Cytoplasmic (Potential).				signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(2)|pancreas(1)	5						GAAAGACCTTCTCCACTCTTG	0.428		NaN											0	0	0	0.008871	0	21	37									
KCNK10	54207	broad.mit.edu	37	14	88693853	88693853	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr14:88693853C>T	uc001xwo.2	-	4	989	c.532G>A	c.(532-534)GAA>AAA	p.E178K	KCNK10_uc001xwm.2_Missense_Mutation_p.E183K|KCNK10_uc001xwn.2_Missense_Mutation_p.E183K	NM_021161	NP_066984	P57789	KCNKA_HUMAN	potassium channel, subfamily K, member 10	178					signal transduction	integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(2)|pancreas(1)	5						TTGCCTCCTTCAGTGCTCGGA	0.403		NaN											0	0	0	0.01892	0	25	63									
CDC42BPB	9578	broad.mit.edu	37	14	103416915	103416915	+	Missense_Mutation	SNP	G	G	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr14:103416915G>T	uc001ymi.1	-	25	3429	c.3197C>A	c.(3196-3198)TCC>TAC	p.S1066Y	CDC42BPB_uc001ymj.1_Missense_Mutation_p.S168Y	NM_006035	NP_006026	Q9Y5S2	MRCKB_HUMAN	CDC42-binding protein kinase beta	1066	Phorbol-ester/DAG-type.				actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			large_intestine(3)|skin(3)|lung(2)|stomach(1)|breast(1)|ovary(1)	11		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		GTCTTTGCAGGACACGTGGCA	0.572		NaN											1	0	1.96292e-10	0.010504	2.08956e-10	20	31									
TJP1	7082	broad.mit.edu	37	15	30019056	30019056	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr15:30019056G>A	uc001zcr.2	-	17	2715	c.2240C>T	c.(2239-2241)TCT>TTT	p.S747F	TJP1_uc010azl.2_Missense_Mutation_p.S735F|TJP1_uc001zcq.2_Missense_Mutation_p.S751F|TJP1_uc001zcs.2_Missense_Mutation_p.S747F	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	747	Guanylate kinase-like.				cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		ACTTTTCCGAGATTCTGGACA	0.363		NaN											0	0	0	0.00874	0	42	67									
RYR3	6263	broad.mit.edu	37	15	34078093	34078093	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr15:34078093G>A	uc001zhi.2	+	66	9569	c.9499G>A	c.(9499-9501)GAA>AAA	p.E3167K	RYR3_uc010bar.2_Missense_Mutation_p.E3167K	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	3167					cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GGTCACCTCTGAACACCTCAG	0.562		NaN											0	0	0	0.01441	0	57	88									
BUB1B	701	broad.mit.edu	37	15	40475992	40475992	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr15:40475992C>G	uc001zkx.3	+	6	871	c.659C>G	c.(658-660)TCT>TGT	p.S220C	BUB1B_uc010ucl.1_Missense_Mutation_p.S83C	NM_001211	NP_001202	O60566	BUB1B_HUMAN	budding uninhibited by benzimidazoles 1 beta	220	BUB1 N-terminal.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|cell division|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic prometaphase|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|phosphatidylinositol-mediated signaling|protein localization to kinetochore|spindle organization	anaphase-promoting complex|condensed chromosome outer kinetochore|cytosol|microtubule organizing center|perinuclear region of cytoplasm|spindle midzone	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(2)|ovary(1)|kidney(1)	4		all_cancers(109;1.12e-18)|all_epithelial(112;1.61e-15)|Lung NSC(122;5.63e-11)|all_lung(180;1.4e-09)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;1.83e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0556)		TTTGAGTCTTCTGTACCACAA	0.448		NaN	Mis|N|F|S			rhabdomyosarcoma			Mosaic_Variegated_Aneuploidy_Syndrome				0	0	0	0.021523	0	26	27									
SHC4	399694	broad.mit.edu	37	15	49148320	49148320	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr15:49148320C>A	uc001zxb.1	-	8	1501	c.1072G>T	c.(1072-1074)GAG>TAG	p.E358*	SHC4_uc010uey.1_Nonsense_Mutation_p.E115*|SHC4_uc010uez.1_Nonsense_Mutation_p.E72*	NM_203349	NP_976224	Q6S5L8	SHC4_HUMAN	rai-like protein	358	PID.				intracellular signal transduction	cell junction|postsynaptic membrane				ovary(3)|pancreas(2)	5		all_lung(180;0.00466)		all cancers(107;9.4e-08)|GBM - Glioblastoma multiforme(94;5.94e-07)		TGCACCTCCTCACTGTGAAGG	0.428		NaN											1	0	4.47668e-21	0.021523	4.85955e-21	27	54									
HERC1	8925	broad.mit.edu	37	15	63908120	63908120	+	Splice_Site	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr15:63908120C>G	uc002amp.2	-	76	14090	c.13942_splice	c.e76-1	p.M4648_splice		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1						protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						GAGGAATCATCTAGGAACAGA	0.358		NaN											0	0	0	0.004672	0	3	4									
ACAN	176	broad.mit.edu	37	15	89392692	89392692	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr15:89392692C>T	uc010upo.1	+	10	2130	c.1756C>T	c.(1756-1758)CTT>TTT	p.L586F	ACAN_uc002bmx.2_Missense_Mutation_p.L586F|ACAN_uc010upp.1_Missense_Mutation_p.L586F|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	586					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CGCCACACGCCTTGAGCAGTT	0.632		NaN											0	0	0	0.001984	0	6	8									
CREBBP	1387	broad.mit.edu	37	16	3788651	3788651	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:3788651C>G	uc002cvv.2	-	26	4507	c.4303G>C	c.(4303-4305)GAT>CAT	p.D1435H	CREBBP_uc002cvw.2_Missense_Mutation_p.D1397H	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1435	Cys/His-rich.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding	p.D1435G(1)|p.D1435E(1)		haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		TGAATACTATCCAGATAAGAA	0.433		NaN	T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				0	0	0	0.014758	0	5	10									
UBN1	29855	broad.mit.edu	37	16	4924401	4924401	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:4924401G>A	uc002cyb.2	+	15	2329	c.1990G>A	c.(1990-1992)GAC>AAC	p.D664N	UBN1_uc010uxw.1_Missense_Mutation_p.D664N|UBN1_uc002cyc.2_Missense_Mutation_p.D664N	NM_001079514	NP_001072982	Q9NPG3	UBN1_HUMAN	ubinuclein 1	664					chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						ATTGGATGAAGACTTGATCCG	0.577		NaN											0	0	0	0.021022	0	40	102									
SMG1	23049	broad.mit.edu	37	16	18841068	18841068	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:18841068G>A	uc002dfm.2	-	54	9506	c.9143C>T	c.(9142-9144)TCA>TTA	p.S3048L	SMG1_uc010bwb.2_Missense_Mutation_p.S2908L|SMG1_uc010bwa.2_Missense_Mutation_p.S1779L	NM_015092	NP_055907	Q96Q15	SMG1_HUMAN	PI-3-kinase-related kinase SMG-1	3048					DNA repair|mRNA export from nucleus|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|peptidyl-serine phosphorylation|phosphatidylinositol phosphorylation|protein autophosphorylation	cytoplasm|nucleus	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			breast(5)|stomach(4)|lung(4)|kidney(2)|ovary(1)	16						ATCTTCAAGTGAACTTGATCC	0.323		NaN											0	0	0	0.020292	0	14	15									
RBL2	5934	broad.mit.edu	37	16	53524211	53524211	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:53524211G>A	uc002ehi.3	+	22	3537	c.3419G>A	c.(3418-3420)TGA>TAA	p.*1140*	RBL2_uc002ehj.2_Silent_p.*850*|RBL2_uc010vgw.1_Silent_p.*519*	NM_005611	NP_005602	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)	1140					cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						GGTTCCCACTGAGGTTAGTCT	0.403		NaN											0	0	0	0.028581	0	16	36									
SLC9A5	6553	broad.mit.edu	37	16	67291253	67291253	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:67291253G>C	uc002esm.2	+	8	1404	c.1341G>C	c.(1339-1341)TTG>TTC	p.L447F	SLC9A5_uc010cee.2_Missense_Mutation_p.L152F|SLC9A5_uc010vji.1_5'UTR	NM_004594	NP_004585	Q14940	SL9A5_HUMAN	solute carrier family 9 (sodium/hydrogen	447	Helical; (Potential).				regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			ovary(1)|pancreas(1)	2		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)		CATAGGGCTTGACCATCAAGC	0.542		NaN											0	0	0	0.013537	0	13	39									
KCTD19	146212	broad.mit.edu	37	16	67324842	67324842	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:67324842G>A	uc002esu.2	-	15	2664	c.2613C>T	c.(2611-2613)ATC>ATT	p.I871I	KCTD19_uc002est.2_Silent_p.I643I|KCTD19_uc010vjj.1_Silent_p.I614I	NM_001100915	NP_001094385	Q17RG1	KCD19_HUMAN	potassium channel tetramerisation domain	871						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		TGAAGCCGGTGATGGCCAGCA	0.617		NaN											0	0	0	0.021553	0	4	10									
PRMT7	54496	broad.mit.edu	37	16	68373809	68373809	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:68373809G>C	uc002evy.1	+	9	1141	c.865G>C	c.(865-867)GAG>CAG	p.E289Q	PRMT7_uc002evx.1_Missense_Mutation_p.E289Q|PRMT7_uc010vlg.1_Missense_Mutation_p.E239Q|PRMT7_uc002evz.1_Missense_Mutation_p.E135Q	NM_019023	NP_061896	Q9NVM4	ANM7_HUMAN	protein arginine methyltransferase 7	289					cell differentiation|DNA methylation involved in gamete generation|regulation of gene expression by genetic imprinting|regulation of transcription, DNA-dependent|spliceosomal snRNP assembly|transcription, DNA-dependent	cytosol|nucleus	[myelin basic protein]-arginine N-methyltransferase activity|histone methyltransferase activity (H4-R3 specific)|protein-arginine omega-N monomethyltransferase activity|protein-arginine omega-N symmetric methyltransferase activity|ribonucleoprotein binding				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0155)|Epithelial(162;0.0629)		AATGGACCCTGAGGGGAAGAT	0.572		NaN											0	0	0	0.028581	0	17	20									
PHLPP2	23035	broad.mit.edu	37	16	71718490	71718490	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:71718490C>G	uc002fax.2	-	4	630	c.624G>C	c.(622-624)AAG>AAC	p.K208N	PHLPP2_uc002fav.2_5'Flank|PHLPP2_uc010cgf.2_Missense_Mutation_p.K208N|PHLPP2_uc002fay.1_Missense_Mutation_p.K208N	NM_015020	NP_055835	Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein	208	PH.					cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			ovary(1)|central_nervous_system(1)	2						ATTGCCGTCGCTTCACTTCTT	0.473		NaN											0	0	0	0.001984	0	7	18									
ZFHX3	463	broad.mit.edu	37	16	72831063	72831063	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:72831063G>C	uc002fck.2	-	9	6191	c.5518C>G	c.(5518-5520)CAG>GAG	p.Q1840E	ZFHX3_uc002fcl.2_Missense_Mutation_p.Q926E	NM_006885	NP_008816	Q15911	ZFHX3_HUMAN	zinc finger homeobox 3 isoform A	1840					muscle organ development|negative regulation of myoblast differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|positive regulation of myoblast differentiation	transcription factor complex	enzyme binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(2)|skin(2)	4		Ovarian(137;0.13)				TGTGGGACCTGAACCTGAGCC	0.592		NaN											0	0	0	0.00632	0	30	37									
TMEM231	79583	broad.mit.edu	37	16	75579304	75579304	+	Silent	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:75579304C>G	uc002fem.2	-	4	591	c.528G>C	c.(526-528)CTG>CTC	p.L176L	CHST5_uc002fej.1_5'UTR|TMEM231_uc002fek.2_Silent_p.L205L|TMEM231_uc002fel.2_Silent_p.L60L|TMEM231_uc010vne.1_Silent_p.L29L|TMEM231_uc010cgx.1_Silent_p.L140L	NM_001077418	NP_001070886	Q9H6L2	TM231_HUMAN	transmembrane protein 231 isoform 2	176						integral to membrane					0						GCTGCAGCCTCAGGTCTCCGT	0.542		NaN											0	0	0	0.01441	0	39	47									
KARS	3735	broad.mit.edu	37	16	75663370	75663370	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:75663370C>T	uc002feq.2	-	12	1542	c.1494G>A	c.(1492-1494)GCG>GCA	p.A498A	KARS_uc002fer.2_Silent_p.A526A|KARS_uc002fes.2_Silent_p.A342A	NM_005548	NP_005539	Q15046	SYK_HUMAN	lysyl-tRNA synthetase isoform 2	498					interspecies interaction between organisms|lysyl-tRNA aminoacylation|tRNA processing	cytosol|extracellular region|mitochondrial matrix|nucleus|plasma membrane|soluble fraction	ATP binding|lysine-tRNA ligase activity|metal ion binding|tRNA binding	p.A498A(1)		ovary(2)	2					L-Lysine(DB00123)	GCTCAGTATACGCATTGCATA	0.517		NaN											0	0	0	0.019004	0	36	69									
SPIRE2	84501	broad.mit.edu	37	16	89929916	89929916	+	Silent	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr16:89929916G>C	uc002foz.1	+	11	1660	c.1608G>C	c.(1606-1608)CTG>CTC	p.L536L	SPIRE2_uc010ciw.1_Silent_p.L536L|SPIRE2_uc002fpa.1_Silent_p.L488L|SPIRE2_uc010cix.1_Silent_p.L403L	NM_032451	NP_115827	Q8WWL2	SPIR2_HUMAN	spire homolog 2	536	Spir-box.				transport	cytoplasm|cytoskeleton	actin binding			central_nervous_system(1)	1		Lung NSC(15;5.15e-06)|all_lung(18;8.38e-06)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0286)		GCCTGGCGCTGACTGTGGAAG	0.572		NaN											0	0	0	0.010729	0	11	24									
SRR	63826	broad.mit.edu	37	17	2222158	2222158	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:2222158G>C	uc002fue.1	+	4	402	c.334G>C	c.(334-336)GAC>CAC	p.D112H	SRR_uc002fui.1_5'UTR	NM_021947	NP_068766	Q9GZT4	SRR_HUMAN	serine racemase	112					D-serine biosynthetic process|L-serine metabolic process|protein homotetramerization|pyruvate biosynthetic process|response to lipopolysaccharide	cytoplasm|neuronal cell body|soluble fraction	ATP binding|calcium ion binding|D-serine ammonia-lyase activity|glycine binding|L-serine ammonia-lyase activity|magnesium ion binding|PDZ domain binding|protein homodimerization activity|pyridoxal phosphate binding|serine racemase activity|threonine racemase activity				0		Colorectal(1115;3.46e-05)|Myeloproliferative disorder(207;0.0255)		COAD - Colon adenocarcinoma(228;3.24e-06)|READ - Rectum adenocarcinoma(1115;0.0649)	L-Serine(DB00133)|Pyridoxal Phosphate(DB00114)	GACAGCTCCAGACTGTAAAAA	0.423		NaN											0	0	0	0.01441	0	79	33									
ATP2A3	489	broad.mit.edu	37	17	3854917	3854917	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:3854917G>A	uc002fxb.1	-	4	433	c.282C>T	c.(280-282)ATC>ATT	p.I94I	ATP2A3_uc002fwx.1_Silent_p.I94I|ATP2A3_uc002fwy.1_Silent_p.I94I|ATP2A3_uc002fwz.1_Silent_p.I94I|ATP2A3_uc002fxa.1_Silent_p.I94I|ATP2A3_uc002fxc.1_Silent_p.I94I|ATP2A3_uc002fxd.1_Silent_p.I94I	NM_174955	NP_777615	Q93084	AT2A3_HUMAN	ATPase, Ca++ transporting, ubiquitous isoform b	94	Helical; Name=2; (By similarity).				ATP biosynthetic process|platelet activation	integral to membrane|nuclear membrane|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	ATP binding|calcium-transporting ATPase activity|metal ion binding|protein binding			ovary(3)|breast(1)|central_nervous_system(1)	5				LUAD - Lung adenocarcinoma(1115;0.000692)|Lung(3;0.0766)		GGATCAGCATGATGACCAGGG	0.687		NaN											0	0	0	0.006214	0	9	4									
NCOR1	9611	broad.mit.edu	37	17	15960870	15960870	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:15960870G>C	uc002gpo.2	-	40	6590	c.6350C>G	c.(6349-6351)TCA>TGA	p.S2117*	NCOR1_uc002gpn.2_Nonsense_Mutation_p.S2014*|NCOR1_uc002gpl.2_Nonsense_Mutation_p.S132*|NCOR1_uc002gpm.2_Nonsense_Mutation_p.S637*|NCOR1_uc010vwb.1_Nonsense_Mutation_p.S701*|NCOR1_uc010coy.2_Nonsense_Mutation_p.S1025*|NCOR1_uc010vwc.1_Nonsense_Mutation_p.S927*	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	2117	Interaction with C1D (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		AGAGACCCTTGAACCTGGTCT	0.408		NaN											0	0	0	0.015359	0	33	62									
NCOR1	9611	broad.mit.edu	37	17	15960927	15960927	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:15960927G>A	uc002gpo.2	-	40	6533	c.6293C>T	c.(6292-6294)TCA>TTA	p.S2098L	NCOR1_uc002gpn.2_Missense_Mutation_p.S1995L|NCOR1_uc002gpl.2_Missense_Mutation_p.S113L|NCOR1_uc002gpm.2_Missense_Mutation_p.S618L|NCOR1_uc010vwb.1_Missense_Mutation_p.S682L|NCOR1_uc010coy.2_Missense_Mutation_p.S1006L|NCOR1_uc010vwc.1_Missense_Mutation_p.S908L	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	2098	Interaction with C1D (By similarity).|ID1 (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		GTAACGGTTTGATGTTTTAGT	0.483		NaN											0	0	0	0.014323	0	22	50									
NCOR1	9611	broad.mit.edu	37	17	15961794	15961794	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:15961794G>C	uc002gpo.2	-	38	6241	c.6001C>G	c.(6001-6003)CAA>GAA	p.Q2001E	NCOR1_uc002gpn.2_Missense_Mutation_p.Q1898E|NCOR1_uc002gpl.2_5'Flank|NCOR1_uc002gpm.2_Missense_Mutation_p.Q521E|NCOR1_uc010vwb.1_Missense_Mutation_p.Q585E|NCOR1_uc010coy.2_Missense_Mutation_p.Q909E|NCOR1_uc010vwc.1_Missense_Mutation_p.Q811E	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	2001	Interaction with C1D (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		CTTTCCGCTTGATTTGCCTTA	0.413		NaN											0	0	0	0.00632	0	26	60									
RAI1	10743	broad.mit.edu	37	17	17700785	17700785	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:17700785C>T	uc002grm.2	+	3	4992	c.4523C>T	c.(4522-4524)TCC>TTC	p.S1508F	RAI1_uc002grn.1_Missense_Mutation_p.S1508F	NM_030665	NP_109590	Q7Z5J4	RAI1_HUMAN	retinoic acid induced 1	1508						cytoplasm|nucleus	zinc ion binding			central_nervous_system(1)|skin(1)	2				READ - Rectum adenocarcinoma(1115;0.0276)		GGCCTGGCCTCCCAGCCCCCG	0.642		NaN											0	0	0	0.00632	0	29	6									
NLK	51701	broad.mit.edu	37	17	26518092	26518092	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:26518092G>C	uc010crj.2	+	9	1494	c.1282G>C	c.(1282-1284)GAT>CAT	p.D428H	NLK_uc010cri.1_RNA	NM_016231	NP_057315	Q9UBE8	NLK_HUMAN	nemo like kinase	428					intracellular protein kinase cascade|negative regulation of Wnt receptor signaling pathway|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|serine phosphorylation of STAT3 protein|transcription, DNA-dependent|transforming growth factor beta receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|nucleus	ATP binding|magnesium ion binding|MAP kinase activity|SH2 domain binding|transcription factor binding|ubiquitin protein ligase binding			ovary(1)|lung(1)|central_nervous_system(1)	3	all_lung(13;0.000343)|Lung NSC(42;0.00184)			UCEC - Uterine corpus endometrioid carcinoma (53;0.168)		CCCCTACCTAGATGAAGGGCG	0.438		NaN											0	0	0	0.014323	0	21	70									
SRCIN1	80725	broad.mit.edu	37	17	36704795	36704795	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:36704795C>G	uc002hqd.2	-	17	3493	c.3268G>C	c.(3268-3270)GAG>CAG	p.E1090Q	SRCIN1_uc002hqf.1_Missense_Mutation_p.E962Q|SRCIN1_uc002hqe.2_Missense_Mutation_p.E944Q	NM_025248	NP_079524	Q9C0H9	SRCN1_HUMAN	SNAP25-interacting protein	962					exocytosis|negative regulation of protein tyrosine kinase activity|positive regulation of protein tyrosine kinase activity|regulation of cell migration|regulation of dendritic spine morphogenesis|substrate adhesion-dependent cell spreading	actin cytoskeleton|axon|cell junction|cytoplasm|dendrite|postsynaptic density|postsynaptic membrane	protein kinase binding				0						TGACCTACCTCTAGCTCTGCG	0.662		NaN											0	0	0	0.010504	0	22	58									
ERBB2	2064	broad.mit.edu	37	17	37880220	37880220	+	Missense_Mutation	SNP	T	T	C	rs121913470		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08			T	C	T	T		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:37880220T>C	uc002hso.2	+	19	2502	c.2264T>C	c.(2263-2265)TTG>TCG	p.L755S	ERBB2_uc002hsm.2_Missense_Mutation_p.L725S|ERBB2_uc010cwa.2_Missense_Mutation_p.L740S|ERBB2_uc002hsp.2_Missense_Mutation_p.L558S|ERBB2_uc010cwb.2_Missense_Mutation_p.L755S|ERBB2_uc010wek.1_Missense_Mutation_p.L479S	NM_004448	NP_004439	P04626	ERBB2_HUMAN	erbB-2 isoform a	755	Cytoplasmic (Potential).|Protein kinase.		L -> P (in a lung adenocarcinoma sample; somatic mutation).		cell proliferation|heart development|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of cell adhesion|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|protein autophosphorylation|regulation of angiogenesis|regulation of microtubule-based process|regulation of transcription, DNA-dependent|transcription, DNA-dependent|wound healing	integral to membrane|nucleus|perinuclear region of cytoplasm|receptor complex	ATP binding|DNA binding|epidermal growth factor receptor activity|ErbB-3 class receptor binding|identical protein binding|protein C-terminus binding|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.L755S(4)|p.L755P(2)|p.L755_S760>A(1)		lung(73)|central_nervous_system(16)|ovary(16)|stomach(14)|breast(9)|upper_aerodigestive_tract(5)|large_intestine(3)|liver(3)|endometrium(2)|skin(1)|pancreas(1)	143	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)	Ovarian(249;0.0547)|Colorectal(1115;0.234)	UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;9.42e-64)|all cancers(3;5.61e-57)|BRCA - Breast invasive adenocarcinoma(8;2.5e-45)|STAD - Stomach adenocarcinoma(3;9.03e-13)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)	UCEC - Uterine corpus endometrioid carcinoma (308;0.0767)	Lapatinib(DB01259)|Letrozole(DB01006)|Trastuzumab(DB00072)	ATCAAAGTGTTGAGGGAAAAC	0.532	L755S(LN229_CENTRAL_NERVOUS_SYSTEM)	1	A|Mis|O		breast|ovarian|other tumour types|NSCLC|gastric					TCGA GBM(5;<1E-08)			0	0	0	0.024245	0	16	22									
SLC25A39	51629	broad.mit.edu	37	17	42400878	42400878	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:42400878G>A	uc002ign.2	-	2	207	c.53C>T	c.(52-54)TCA>TTA	p.S18L	SLC25A39_uc002igm.2_Missense_Mutation_p.S18L|SLC25A39_uc002igo.2_Missense_Mutation_p.S18L|SLC25A39_uc010wiw.1_Missense_Mutation_p.S18L|SLC25A39_uc010czu.2_Intron|SLC25A39_uc010wix.1_Missense_Mutation_p.S18L|SLC25A39_uc010wiy.1_Missense_Mutation_p.S18L	NM_001143780	NP_001137252	Q9BZJ4	S2539_HUMAN	solute carrier family 25, member 39 isoform a	18	Solcar 1.|Helical; Name=1; (Potential).				heme biosynthetic process|transport	integral to membrane|mitochondrial inner membrane				upper_aerodigestive_tract(1)	1		Prostate(33;0.0233)		BRCA - Breast invasive adenocarcinoma(366;0.189)		CCCGGTGCCTGAGGCCACCAT	0.607		NaN											0	0	0	0.004672	0	3	3									
TTLL6	284076	broad.mit.edu	37	17	46862467	46862467	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:46862467C>A	uc010wlo.1	-	14	1893	c.1858G>T	c.(1858-1860)GAG>TAG	p.E620*	TTLL6_uc002iob.2_Nonsense_Mutation_p.E313*|TTLL6_uc010dbi.2_RNA|TTLL6_uc002ioc.2_Nonsense_Mutation_p.E373*|TTLL6_uc002iod.2_Nonsense_Mutation_p.E467*	NM_001130918	NP_001124390	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	572						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity				0						GTGGGAGCCTCCTGGTTGAGG	0.507		NaN											1	0	2.68985e-26	0.01441	2.92954e-26	49	100									
TTLL6	284076	broad.mit.edu	37	17	46862485	46862485	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:46862485C>T	uc010wlo.1	-	14	1875	c.1840G>A	c.(1840-1842)GAC>AAC	p.D614N	TTLL6_uc002iob.2_Missense_Mutation_p.D307N|TTLL6_uc010dbi.2_RNA|TTLL6_uc002ioc.2_Missense_Mutation_p.D367N|TTLL6_uc002iod.2_Missense_Mutation_p.D461N	NM_001130918	NP_001124390	Q8N841	TTLL6_HUMAN	tubulin tyrosine ligase-like family, member 6	566						cilium|microtubule basal body	ATP binding|tubulin binding|tubulin-tyrosine ligase activity				0						AGGCTGCTGTCTGTTTCATTT	0.512		NaN											0	0	0	0.013114	0	48	96									
SPOP	8405	broad.mit.edu	37	17	47688672	47688672	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:47688672C>G	uc010dbk.2	-	7	1260	c.628G>C	c.(628-630)GAA>CAA	p.E210Q	SPOP_uc002ipb.2_Missense_Mutation_p.E210Q|SPOP_uc002ipc.2_Missense_Mutation_p.E210Q|SPOP_uc002ipd.2_Missense_Mutation_p.E210Q|SPOP_uc002ipe.2_Missense_Mutation_p.E210Q|SPOP_uc002ipf.2_Missense_Mutation_p.E210Q|SPOP_uc002ipg.2_Missense_Mutation_p.E210Q	NM_003563	NP_003554	O43791	SPOP_HUMAN	speckle-type POZ protein	210	BTB.				mRNA processing	nucleus	protein binding			prostate(2)|ovary(2)|lung(2)	6						GCCTGGAATTCCTGGCCGGCA	0.453		NaN								Prostate(2;0.17)			0	0	0	0.01441	0	77	94									
NOG	9241	broad.mit.edu	37	17	54671875	54671875	+	Silent	SNP	C	C	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:54671875C>A	uc002iup.2	+	1	816	c.291C>A	c.(289-291)GGC>GGA	p.G97G		NM_005450	NP_005441	Q13253	NOGG_HUMAN	noggin precursor	97					BMP signaling pathway|cartilage development|cell differentiation in hindbrain|dorsal/ventral pattern formation|embryonic digit morphogenesis|embryonic skeletal joint morphogenesis|epithelial to mesenchymal transition|fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation|middle ear morphogenesis|negative regulation of astrocyte differentiation|negative regulation of BMP signaling pathway|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of cytokine activity|negative regulation of osteoblast differentiation|osteoblast differentiation|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of glomerulus development|somatic stem cell maintenance|wound healing	extracellular space	cytokine binding|protein homodimerization activity				0	Breast(9;5.24e-08)					CAGCTGGGGGCGCGGAGGACC	0.647		NaN											1	0	0.000274275	0.004482	0.000282846	9	7									
C17orf71	55181	broad.mit.edu	37	17	57288781	57288781	+	Missense_Mutation	SNP	G	G	C	rs5821255		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:57288781G>C	uc002ixi.2	+	1	1411	c.1369G>C	c.(1369-1371)GAG>CAG	p.E457Q		NM_018149	NP_060619	Q8ND04	SMG8_HUMAN	SMG8 protein	457					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding				0	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)					AAAACTGTATGAGGTGGCTAT	0.438		NaN											0	0	0	0.009718	0	44	64									
USP32	84669	broad.mit.edu	37	17	58288867	58288867	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:58288867C>G	uc002iyo.1	-	20	2474	c.2188G>C	c.(2188-2190)GAA>CAA	p.E730Q	USP32_uc002iyn.1_Missense_Mutation_p.E400Q	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	730					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			GCTCCCTTTTCTGTGGGAACT	0.383		NaN											0	0	0	0.009718	0	39	126									
USP32	84669	broad.mit.edu	37	17	58289433	58289433	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:58289433C>G	uc002iyo.1	-	19	2417	c.2131G>C	c.(2131-2133)GAG>CAG	p.E711Q	USP32_uc002iyn.1_Missense_Mutation_p.E381Q	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	711					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			GACATCTCCTCAGGCCAACTC	0.289		NaN											0	0	0	0.010729	0	10	43									
INTS2	57508	broad.mit.edu	37	17	59946642	59946642	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:59946642C>G	uc002izn.2	-	22	3230	c.3154G>C	c.(3154-3156)GAG>CAG	p.E1052Q	INTS2_uc002izm.2_Missense_Mutation_p.E1044Q	NM_020748	NP_065799	Q9H0H0	INT2_HUMAN	integrator complex subunit 2	1052					snRNA processing	integral to membrane|integrator complex|nuclear membrane	protein binding			ovary(1)|lung(1)|pancreas(1)	3						ACCTGTTTCTCAAGTTCTGGC	0.378		NaN											0	0	0	0.016723	0	14	14									
TANC2	26115	broad.mit.edu	37	17	61499280	61499280	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:61499280C>G	uc002jal.3	+	25	5960	c.5937C>G	c.(5935-5937)ATC>ATG	p.I1979M	TANC2_uc010wpe.1_3'UTR|TANC2_uc002jao.3_Missense_Mutation_p.I1090M	NM_025185	NP_079461	Q9HCD6	TANC2_HUMAN	tetratricopeptide repeat, ankyrin repeat and	1979							binding			ovary(2)	2						CATCCCCTATCAAACCAAAGA	0.498		NaN											0	0	0	0.024334	0	28	40									
MFSD11	79157	broad.mit.edu	37	17	74737112	74737112	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:74737112C>T	uc002jta.2	+	4	1199	c.226C>T	c.(226-228)CAA>TAA	p.Q76*	MFSD11_uc002jtb.2_Nonsense_Mutation_p.Q76*|MFSD11_uc010dha.2_Nonsense_Mutation_p.Q76*|MFSD11_uc002jtc.2_Nonsense_Mutation_p.Q76*|MFSD11_uc002jtd.3_Nonsense_Mutation_p.Q76*|MFSD11_uc010dhb.2_Nonsense_Mutation_p.Q76*|MFSD11_uc002jte.2_Nonsense_Mutation_p.Q76*	NM_024311	NP_077287	O43934	MFS11_HUMAN	major facilitator superfamily domain containing	76	Helical; (Potential).					integral to membrane				ovary(1)	1						TGTAGGACCTCAACTCTCTAT	0.373		NaN											0	0	0	0.01441	0	58	96									
RNF213	57674	broad.mit.edu	37	17	78318559	78318559	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:78318559G>A	uc002jyh.1	+	4	866	c.643G>A	c.(643-645)GAG>AAG	p.E215K		NM_020914	NP_065965	Q9HCF4	ALO17_HUMAN	ring finger protein 213	Error:Variant_position_missing_in_Q9HCF4_after_alignment										ovary(8)|lung(6)|breast(3)|large_intestine(2)|central_nervous_system(1)|pancreas(1)	21	all_neural(118;0.0538)		BRCA - Breast invasive adenocarcinoma(99;0.0252)|OV - Ovarian serous cystadenocarcinoma(97;0.057)			GATAGACATGGAGCTGAGTGC	0.488		NaN											0	0	0	0.01441	0	81	125									
SLC14A1	6563	broad.mit.edu	37	18	43328388	43328388	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr18:43328388G>C	uc010xcn.1	+	10	1313	c.994G>C	c.(994-996)GAG>CAG	p.E332Q	SLC14A1_uc010dnk.2_Missense_Mutation_p.E388Q|SLC14A1_uc002lbf.3_Missense_Mutation_p.E332Q|SLC14A1_uc002lbg.3_RNA|SLC14A1_uc010xco.1_Missense_Mutation_p.E227Q|SLC14A1_uc002lbh.3_Missense_Mutation_p.E224Q|SLC14A1_uc002lbi.3_Missense_Mutation_p.E200Q|SLC14A1_uc002lbj.3_Missense_Mutation_p.E388Q|SLC14A1_uc002lbk.3_Missense_Mutation_p.E332Q	NM_001146036	NP_001139508	Q13336	UT1_HUMAN	solute carrier family 14 (urea transporter),	332						integral to plasma membrane	urea transmembrane transporter activity			central_nervous_system(1)|pancreas(1)	2						CTTTATGGCTGAGGTGAGTTT	0.448		NaN											0	0	0	0.014323	0	24	52									
SERPINB8	5271	broad.mit.edu	37	18	61647088	61647088	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr18:61647088C>T	uc002ljv.2	+	3	391	c.222C>T	c.(220-222)CTC>CTT	p.L74L	SERPINB8_uc002ljs.1_Silent_p.L74L|SERPINB8_uc002ljt.2_Silent_p.L74L|SERPINB8_uc002lju.2_Silent_p.L74L|SERPINB8_uc010xex.1_5'UTR	NM_198833	NP_942130	P50452	SPB8_HUMAN	serine (or cysteine) proteinase inhibitor, clade	74					regulation of proteolysis	cytosol	protein binding|serine-type endopeptidase inhibitor activity			skin(1)	1		Esophageal squamous(42;0.129)				AGTCACTTCTCAGTGAAGTTA	0.418		NaN									OREG0025042	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.027894	0	40	71									
SOCS6	9306	broad.mit.edu	37	18	67992983	67992983	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr18:67992983C>T	uc002lkr.1	+	2	1395	c.1079C>T	c.(1078-1080)TCA>TTA	p.S360L	SOCS6_uc010dqq.2_Missense_Mutation_p.S360L	NM_004232	NP_004223	O14544	SOCS6_HUMAN	suppressor of cytokine signaling 6	360					defense response|JAK-STAT cascade|negative regulation of signal transduction|regulation of growth	cytoplasm				large_intestine(1)|lung(1)	2		Esophageal squamous(42;0.129)|Colorectal(73;0.152)				GTTTATGACTCAGTGCAAAGT	0.493		NaN											0	0	0	0.020292	0	15	37									
MIDN	90007	broad.mit.edu	37	19	1255046	1255046	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:1255046C>G	uc002lrp.2	+	6	1357	c.842C>G	c.(841-843)TCA>TGA	p.S281*		NM_177401	NP_796375	Q504T8	MIDN_HUMAN	midnolin	281						nucleolus					0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGGGTCTTCTCAGGGACCTTC	0.637		NaN											0	0	0	0.008871	0	18	65									
LRG1	116844	broad.mit.edu	37	19	4538815	4538815	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:4538815C>T	uc002mau.2	-	2	192	c.181G>A	c.(181-183)GAA>AAA	p.E61K	PLIN5_uc002mat.1_Intron	NM_052972	NP_443204	P02750	A2GL_HUMAN	leucine-rich alpha-2-glycoprotein 1 precursor	61						extracellular region|membrane				ovary(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		CCGGGGATTTCGGCAGGTGGT	0.637		NaN											0	0	0	0.021553	0	6	61									
KRI1	65095	broad.mit.edu	37	19	10670361	10670361	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:10670361G>C	uc002moy.1	-	11	978	c.969C>G	c.(967-969)ATC>ATG	p.I323M	KRI1_uc002mow.1_Translation_Start_Site|KRI1_uc002mox.1_Missense_Mutation_p.I319M	NM_023008	NP_075384	Q8N9T8	KRI1_HUMAN	KRI1 homolog	323	Glu-rich.									ovary(1)	1			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			CGGAGGACGCGATGCTGCGTG	0.617		NaN											0	0	0	0.00499	0	17	49									
NOTCH3	4854	broad.mit.edu	37	19	15281188	15281188	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:15281188G>A	uc002nan.2	-	27	5144	c.5068C>T	c.(5068-5070)CAC>TAC	p.H1690Y		NM_000435	NP_000426	Q9UM47	NOTC3_HUMAN	Notch homolog 3 precursor	1690	Cytoplasmic (Potential).				Notch receptor processing|Notch signaling pathway|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			lung(8)|ovary(5)|skin(4)|prostate(2)|central_nervous_system(1)|breast(1)	21			OV - Ovarian serous cystadenocarcinoma(3;2.6e-20)|Epithelial(3;1.34e-16)|all cancers(3;5.13e-15)			CGGCCCTTGTGACCAGAGGCC	0.657		NaN											0	0	0	0.024245	0	15	32									
NWD1	284434	broad.mit.edu	37	19	16902160	16902160	+	Splice_Site	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:16902160G>C	uc002neu.3	+	14	3363	c.2941_splice	c.e14-1	p.I981_splice	NWD1_uc002net.3_Splice_Site_p.I846_splice|NWD1_uc002nev.3_Splice_Site_p.I775_splice			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;								ATP binding			skin(3)|ovary(2)|pancreas(2)	7						TATTCTATTAGATCAATGCTT	0.483		NaN											0	0	0	0.010818	0	31	69									
ZNF430	80264	broad.mit.edu	37	19	21240308	21240308	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:21240308G>C	uc002npj.2	+	5	1304	c.1194G>C	c.(1192-1194)GAG>GAC	p.E398D	ZNF430_uc002npk.2_Missense_Mutation_p.E397D	NM_025189	NP_079465	Q9H8G1	ZN430_HUMAN	zinc finger protein 430	398					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)	2						ATACTGGAGAGAAATTCTACA	0.353		NaN											0	0	0	0.006214	0	10	46									
C19orf40	91442	broad.mit.edu	37	19	33467384	33467384	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:33467384G>A	uc002nud.3	+	5	562	c.444G>A	c.(442-444)AAG>AAA	p.K148K		NM_152266	NP_689479	Q9BTP7	FAP24_HUMAN	Fanconi anemia-associated protein, 24 kDa	148					DNA repair	Fanconi anaemia nuclear complex	chromatin binding|DNA binding|protein binding				0	Esophageal squamous(110;0.137)					TTCTCGGGAAGAAACGGGCCC	0.547		NaN						Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks			OREG0025408	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.007291	0	29	68									
MAP4K1	11184	broad.mit.edu	37	19	39104548	39104548	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:39104548G>A	uc002oix.1	-	8	613	c.505C>T	c.(505-507)CGC>TGC	p.R169C	MAP4K1_uc002oiy.1_Missense_Mutation_p.R169C|MAP4K1_uc010xug.1_Translation_Start_Site	NM_007181	NP_009112	Q92918	M4K1_HUMAN	mitogen-activated protein kinase kinase kinase	169	Protein kinase.				activation of JUN kinase activity|peptidyl-serine phosphorylation		ATP binding|MAP kinase kinase kinase kinase activity|protein binding|small GTPase regulator activity			skin(4)|lung(3)|ovary(1)	8	all_cancers(60;6.42e-06)|Ovarian(47;0.103)		Lung(45;0.000751)|LUSC - Lung squamous cell carcinoma(53;0.00272)			AAAGAGAGGCGTCTGGCCAGT	0.627		NaN											0	0	0	0.001984	0	7	16									
SUPT5H	6829	broad.mit.edu	37	19	39955605	39955605	+	Silent	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:39955605C>G	uc002olo.3	+	11	971	c.792C>G	c.(790-792)CTC>CTG	p.L264L	SUPT5H_uc002olp.3_Silent_p.L264L|SUPT5H_uc002olq.3_Silent_p.L260L|SUPT5H_uc002oln.3_Silent_p.L264L|SUPT5H_uc002olr.3_Silent_p.L264L|SUPT5H_uc002ols.1_5'Flank	NM_001111020	NP_001104490	O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog isoform a	264	Interaction with SUPT4H1.				cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			ovary(3)|pancreas(1)	4	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			CAGACGTGCTCAAAGTGGTGA	0.602		NaN											0	0	0	0.010504	0	22	71									
DYRK1B	9149	broad.mit.edu	37	19	40316442	40316442	+	Silent	SNP	T	T	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:40316442T>G	uc002omj.2	-	11	2083	c.1803A>C	c.(1801-1803)CCA>CCC	p.P601P	DYRK1B_uc002omi.2_Silent_p.P573P|DYRK1B_uc002omk.2_Silent_p.P561P	NM_004714	NP_004705	Q9Y463	DYR1B_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	601					positive regulation of transcription, DNA-dependent	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|transcription coactivator activity			ovary(4)|stomach(1)|central_nervous_system(1)|skin(1)	7	all_cancers(60;5.79e-06)|all_lung(34;5.2e-08)|Lung NSC(34;6.14e-08)|Ovarian(47;0.06)		Epithelial(26;5.74e-25)|OV - Ovarian serous cystadenocarcinoma(5;3.13e-24)|all cancers(26;8.59e-23)			GCGGGAGGGGTGGACGACCTC	0.716		NaN											0	0	0	0.001984	0	5	8									
PVR	5817	broad.mit.edu	37	19	45157217	45157217	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:45157217G>A	uc002ozm.2	+	4	1072	c.773G>A	c.(772-774)GGC>GAC	p.G258D	PVR_uc010ejs.2_Missense_Mutation_p.G258D|PVR_uc010xxb.1_Missense_Mutation_p.G258D|PVR_uc010xxc.1_Missense_Mutation_p.G258D|PVR_uc002ozn.2_Missense_Mutation_p.G203D	NM_006505	NP_006496	P15151	PVR_HUMAN	poliovirus receptor isoform alpha	258	Extracellular (Potential).|Ig-like C2-type 2.				adherens junction organization|cell adhesion|cell junction assembly|interspecies interaction between organisms|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target|susceptibility to natural killer cell mediated cytotoxicity|susceptibility to T cell mediated cytotoxicity	cell junction|cell surface|cytoplasm|extracellular space|integral to membrane|nucleus	cell adhesion molecule binding|receptor activity				0	Lung NSC(12;0.00608)|all_lung(12;0.0148)	Medulloblastoma(540;0.0425)|Ovarian(192;0.0728)|Prostate(69;0.081)|all_neural(266;0.112)		Epithelial(262;0.000601)		TGGTACCTTGGCCAGAATGAG	0.493		NaN											0	0	0	0.01441	0	88	71									
FOSB	2354	broad.mit.edu	37	19	45976195	45976195	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:45976195C>T	uc002pbx.3	+	4	1534	c.942C>T	c.(940-942)TTC>TTT	p.F314F	ERCC1_uc002pbu.1_Intron|FOSB_uc010eke.2_Silent_p.F239F|FOSB_uc002pby.3_Silent_p.F278F|FOSB_uc010eka.1_3'UTR|FOSB_uc010ekb.1_3'UTR|FOSB_uc010ekc.1_3'UTR|FOSB_uc010ekf.2_Silent_p.F275F|FOSB_uc010ekd.1_3'UTR|FOSB_uc010ekg.2_Silent_p.F171F|FOSB_uc002pca.3_Silent_p.F265F	NM_006732	NP_006723	P53539	FOSB_HUMAN	FBJ murine osteosarcoma viral oncogene homolog B	314					behavior|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(2)|lung(1)	3		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00814)|Epithelial(262;0.18)|GBM - Glioblastoma multiforme(486;0.242)		TCTCCGCGTTCGCCGGCGCCC	0.577		NaN											0	0	0	0.012319	0	22	66									
SLC8A2	6543	broad.mit.edu	37	19	47969393	47969393	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:47969393C>T	uc002pgx.2	-	2	546	c.268G>A	c.(268-270)GCC>ACC	p.A90T	SLC8A2_uc010xyq.1_Intron|SLC8A2_uc010xyr.1_Intron|SLC8A2_uc010ele.2_Missense_Mutation_p.A90T	NM_015063	NP_055878	Q9UPR5	NAC2_HUMAN	solute carrier family 8 member 2 precursor	90	Helical; (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(1)	4		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		AAACGGTCGGCGATGATGGAC	0.597		NaN											0	0	0	0.010504	0	20	41									
FUZ	80199	broad.mit.edu	37	19	50310577	50310577	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:50310577C>G	uc002ppq.1	-	11	1193	c.1088G>C	c.(1087-1089)AGA>ACA	p.R363T	FUZ_uc002ppr.1_Missense_Mutation_p.R263T|FUZ_uc002pps.1_RNA|FUZ_uc002ppt.1_RNA|FUZ_uc002ppu.1_Missense_Mutation_p.R327T|FUZ_uc002ppv.1_Missense_Mutation_p.R313T	NM_025129	NP_079405	Q9BT04	FUZZY_HUMAN	fuzzy homolog	363	Leu-rich.				cilium assembly|embryonic body morphogenesis|embryonic skeletal system morphogenesis|establishment of planar polarity|hair follicle development|neural tube closure|protein transport|regulation of smoothened signaling pathway	cytoplasm|cytoskeleton					0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.107)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00793)|GBM - Glioblastoma multiforme(134;0.0116)		GTAGCAAGCTCTGGGCAGCTG	0.607		NaN											0	0	0	0.014758	0	5	25									
ETFB	2109	broad.mit.edu	37	19	51857428	51857428	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:51857428G>A	uc002pwh.2	-	2	284	c.192C>T	c.(190-192)GTC>GTT	p.V64V	ETFB_uc002pwg.2_Silent_p.V155V	NM_001985	NP_001976	P38117	ETFB_HUMAN	electron-transfer-flavoprotein, beta polypeptide	64					respiratory electron transport chain|transport	mitochondrial matrix	electron carrier activity				0		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000226)|OV - Ovarian serous cystadenocarcinoma(262;0.00661)		GCCCACAGCTGACGGCGATGA	0.428		NaN											0	0	0	0.008291	0	11	26									
SIGLEC8	27181	broad.mit.edu	37	19	51957546	51957546	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:51957546G>A	uc002pwt.2	-	6	1239	c.1172C>T	c.(1171-1173)TCG>TTG	p.S391L	SIGLEC8_uc010yda.1_Missense_Mutation_p.S282L|SIGLEC8_uc002pwu.2_RNA|SIGLEC8_uc010eox.2_Missense_Mutation_p.S298L	NM_014442	NP_055257	Q9NYZ4	SIGL8_HUMAN	sialic acid binding Ig-like lectin 8 precursor	391	Cytoplasmic (Potential).				cell adhesion	integral to membrane	sugar binding|transmembrane receptor activity			ovary(2)|kidney(1)|central_nervous_system(1)|skin(1)	5		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.000627)|OV - Ovarian serous cystadenocarcinoma(262;0.00979)		TGGCCTTGCCGATTTCTTCCT	0.597		NaN											0	0	0	0.010504	0	19	68									
ZNF83	55769	broad.mit.edu	37	19	53116563	53116563	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:53116563G>A	uc002pzu.3	-	2	2499	c.1255C>T	c.(1255-1257)CAT>TAT	p.H419Y	ZNF83_uc002pzv.3_Missense_Mutation_p.H419Y|ZNF83_uc010eps.2_Missense_Mutation_p.H391Y|ZNF83_uc010ept.2_Missense_Mutation_p.H419Y|ZNF83_uc010epu.2_Missense_Mutation_p.H419Y|ZNF83_uc010epv.2_Missense_Mutation_p.H419Y|ZNF83_uc010epw.2_Missense_Mutation_p.H419Y|ZNF83_uc010epx.2_Missense_Mutation_p.H391Y|ZNF83_uc010epy.2_Missense_Mutation_p.H419Y|ZNF83_uc010epz.2_Missense_Mutation_p.H391Y	NM_018300	NP_060770	P51522	ZNF83_HUMAN	zinc finger protein 83 isoform a	419	C2H2-type 12.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.00841)|GBM - Glioblastoma multiforme(134;0.0244)		ATTCTCCAATGATATGCAAGG	0.373		NaN											0	0	0	0.00632	0	28	100									
ZNF665	79788	broad.mit.edu	37	19	53678789	53678789	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:53678789G>A	uc010eqm.1	-	3	151	c.51C>T	c.(49-51)TTC>TTT	p.F17F		NM_024733	NP_079009	Q9H7R5	ZN665_HUMAN	zinc finger protein 665	Error:Variant_position_missing_in_Q9H7R5_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2				GBM - Glioblastoma multiforme(134;0.0196)		CCTCCTGAGAGAATTCTATGG	0.438		NaN											0	0	0	0.027356	0	26	100									
TMC4	147798	broad.mit.edu	37	19	54666454	54666454	+	Missense_Mutation	SNP	T	T	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:54666454T>A	uc010erf.2	-	10	1604	c.1472A>T	c.(1471-1473)GAT>GTT	p.D491V	TMC4_uc002qdn.2_Missense_Mutation_p.D205V|TMC4_uc002qdo.2_Missense_Mutation_p.D485V	NM_001145303	NP_001138775	Q7Z404	TMC4_HUMAN	transmembrane channel-like 4 isoform 1	491	Helical; (Potential).					integral to membrane				pancreas(1)	1	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					AGTCAGCAGATCAAAGAGCAG	0.567		NaN											0	0	0	0.010729	0	11	9									
USP29	57663	broad.mit.edu	37	19	57642078	57642078	+	Missense_Mutation	SNP	G	G	A	rs143453181		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:57642078G>A	uc002qny.2	+	4	2391	c.2035G>A	c.(2035-2037)GAG>AAG	p.E679K		NM_020903	NP_065954	Q9HBJ7	UBP29_HUMAN	ubiquitin specific peptidase 29	679					protein modification process|ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|protein binding|ubiquitin thiolesterase activity			lung(6)|ovary(2)|breast(2)|pancreas(1)	11		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		AAGGCTTGTCGAGGTTCATCT	0.468		NaN											0	0	0	0.006214	0	9	50									
ZSCAN1	284312	broad.mit.edu	37	19	58549427	58549427	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:58549427G>T	uc002qrc.1	+	3	470	c.223G>T	c.(223-225)GAG>TAG	p.E75*	ZSCAN1_uc002qra.1_Nonsense_Mutation_p.E75*|ZSCAN1_uc002qrb.1_Nonsense_Mutation_p.E75*	NM_182572	NP_872378	Q8NBB4	ZSCA1_HUMAN	zinc finger and SCAN domain containing 1	75	SCAN box.				viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.0389)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0152)		GCGCTCCAAGGAGCAGATGCT	0.706		NaN											1	0	0.00116845	0.021553	0.00119008	5	19									
ZBTB45	84878	broad.mit.edu	37	19	59028629	59028629	+	Missense_Mutation	SNP	T	T	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:59028629T>G	uc002qtd.2	-	2	704	c.412A>C	c.(412-414)ACC>CCC	p.T138P	ZBTB45_uc002qte.2_Missense_Mutation_p.T138P|ZBTB45_uc002qtf.2_Missense_Mutation_p.T138P	NM_032792	NP_116181	Q96K62	ZBT45_HUMAN	zinc finger and BTB domain containing 45	138	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(17;1.81e-17)|all_epithelial(17;1.21e-12)|Lung NSC(17;2.8e-05)|all_lung(17;0.000139)|Colorectal(82;0.000147)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0165)|Lung(386;0.18)		GGCACAGGGGTGGGCAGGGGC	0.716		NaN									OREG0025700	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.006214	0	6	3									
TRIM28	10155	broad.mit.edu	37	19	59057194	59057194	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr19:59057194C>T	uc002qtg.1	+	3	806	c.517C>T	c.(517-519)CTG>TTG	p.L173L	TRIM28_uc010eut.1_Intron|TRIM28_uc002qth.1_5'Flank	NM_005762	NP_005753	Q13263	TIF1B_HUMAN	tripartite motif-containing 28 protein	173	RBCC domain.|B box-type 1; atypical.				epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent	nucleoplasm	chromo shadow domain binding|ligase activity|transcription corepressor activity|zinc ion binding			ovary(1)|lung(1)|breast(1)	3		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		CTCGGAGCCTCTGTGTGAGAC	0.572		NaN											0	0	0	0.016723	0	13	36									
OTOF	9381	broad.mit.edu	37	2	26739408	26739408	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:26739408G>A	uc002rhk.2	-	5	514	c.387C>T	c.(385-387)GAC>GAT	p.D129D	OTOF_uc010ylb.1_RNA	NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	129	Cytoplasmic (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AGTCCCCATCGTCCCAGGAGC	0.647		NaN											0	0	0	0.009096	0	4	50									
CCDC121	79635	broad.mit.edu	37	2	27850502	27850502	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:27850502C>T	uc002rle.2	-	2	346	c.165G>A	c.(163-165)GAG>GAA	p.E55E	ZNF512_uc010yly.1_Intron|CCDC121_uc010eze.2_Silent_p.E219E|CCDC121_uc002rld.2_Silent_p.E217E|GPN1_uc010ezf.2_5'Flank|GPN1_uc010yma.1_5'Flank|GPN1_uc010ymb.1_5'Flank|GPN1_uc010ymc.1_5'Flank|GPN1_uc010ymd.1_5'Flank|GPN1_uc010yme.1_5'Flank|GPN1_uc010ezg.1_5'Flank	NM_024584	NP_078860	Q6ZUS5	CC121_HUMAN	coiled-coil domain containing 121 isoform 3	55											0	Acute lymphoblastic leukemia(172;0.155)					TCCATACCTTCTCAGGTTGCT	0.408		NaN											0	0	0	0.01441	0	64	110									
PPP1CB	5500	broad.mit.edu	37	2	29001877	29001877	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:29001877C>G	uc002rmg.2	+	4	547	c.387C>G	c.(385-387)ATC>ATG	p.I129M	PPP1CB_uc010ymj.1_Missense_Mutation_p.I101M|PPP1CB_uc010ymk.1_Missense_Mutation_p.I101M|PPP1CB_uc010yml.1_Missense_Mutation_p.I101M|PPP1CB_uc002rmh.2_Missense_Mutation_p.I129M	NM_206876	NP_996759	P62140	PP1B_HUMAN	protein phosphatase 1, catalytic subunit, beta	129					cell cycle|cell division|glycogen metabolic process|triglyceride catabolic process	MLL5-L complex|nucleolus|PTW/PP1 phosphatase complex	metal ion binding|myosin phosphatase activity|myosin-light-chain-phosphatase activity|protein binding			skin(1)	1	Acute lymphoblastic leukemia(172;0.155)					GTGCTAGCATCAATCGCATTT	0.328		NaN											0	0	0	0.020292	0	15	31									
VIT	5212	broad.mit.edu	37	2	36994239	36994239	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:36994239G>T	uc002rpl.2	+	7	711	c.490G>T	c.(490-492)GAG>TAG	p.E164*	VIT_uc010ynf.1_Intron|VIT_uc002rpm.2_Nonsense_Mutation_p.E157*|VIT_uc010ezv.2_Nonsense_Mutation_p.E157*|VIT_uc010ezw.2_Nonsense_Mutation_p.E157*	NM_053276	NP_444506	Q6UXI7	VITRN_HUMAN	vitrin	164						proteinaceous extracellular matrix				ovary(1)|pancreas(1)	2		all_hematologic(82;0.248)				TCTTACAGGTGAGACCACAAA	0.448		NaN											1	0	1.05317e-09	0.020292	1.11751e-09	13	12									
LHCGR	3973	broad.mit.edu	37	2	48915216	48915216	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:48915216G>A	uc002rwu.3	-	11	1790	c.1720C>T	c.(1720-1722)CTC>TTC	p.L574F	GTF2A1L_uc002rwt.2_Intron	NM_000233	NP_000224	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	574	Helical; Name=6; (Potential).				male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			ovary(3)|lung(2)|breast(2)|skin(1)	8		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	GTGAAGATGAGGATTGCCATT	0.363		NaN							Familial_Male-Limited_Precocious_Puberty				0	0	0	0.025465	0	41	64									
NRXN1	9378	broad.mit.edu	37	2	50724724	50724724	+	Nonsense_Mutation	SNP	C	C	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:50724724C>A	uc010fbq.2	-	14	4223	c.2746G>T	c.(2746-2748)GGA>TGA	p.G916*	NRXN1_uc002rxb.3_Nonsense_Mutation_p.G548*|NRXN1_uc002rxe.3_Nonsense_Mutation_p.G876*|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	239	Extracellular (Potential).|Laminin G-like.				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			TATGCCATTCCATTAAATGTC	0.438		NaN											1	0	0.00448238	0.004482	0.00455134	9	28									
EFEMP1	2202	broad.mit.edu	37	2	56144869	56144869	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:56144869G>A	uc002rzh.2	-	4	778	c.448C>T	c.(448-450)CCC>TCC	p.P150S	EFEMP1_uc002rzi.2_Missense_Mutation_p.P150S|EFEMP1_uc002rzj.2_Missense_Mutation_p.P150S|EFEMP1_uc010ypc.1_Missense_Mutation_p.P92S	NM_004105	NP_004096	Q12805	FBLN3_HUMAN	EGF-containing fibulin-like extracellular matrix	150					negative regulation of chondrocyte differentiation|peptidyl-tyrosine phosphorylation|regulation of transcription, DNA-dependent|visual perception	extracellular space|proteinaceous extracellular matrix	calcium ion binding|epidermal growth factor receptor activity|epidermal growth factor receptor binding|growth factor activity			ovary(4)|pancreas(1)|skin(1)	6			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			GGGTTGGAGGGAATGCGCTGA	0.527		NaN											0	0	0	0.013114	0	47	55									
PLEK	5341	broad.mit.edu	37	2	68607462	68607462	+	Silent	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:68607462G>C	uc002sen.3	+	2	207	c.45G>C	c.(43-45)GGG>GGC	p.G15G	PLEK_uc010fde.2_Silent_p.G15G	NM_002664	NP_002655	P08567	PLEK_HUMAN	pleckstrin	15	PH 1.				actin cytoskeleton reorganization|cortical actin cytoskeleton organization|hemopoietic progenitor cell differentiation|inhibition of phospholipase C activity involved in G-protein coupled receptor signaling pathway|integrin-mediated signaling pathway|negative regulation of calcium-mediated signaling|negative regulation of inositol phosphate biosynthetic process|phosphatidylinositol metabolic process|platelet aggregation|positive regulation of actin filament bundle assembly|positive regulation of actin filament depolymerization|positive regulation of inositol-polyphosphate 5-phosphatase activity|positive regulation of integrin activation|positive regulation of platelet activation|protein kinase C signaling cascade|protein secretion by platelet|regulation of cell diameter|ruffle organization|thrombin receptor signaling pathway|vesicle docking involved in exocytosis	cytosol|extracellular region|membrane fraction|ruffle membrane|soluble fraction	phosphatidylinositol-3,4-bisphosphate binding|protein homodimerization activity|protein kinase C binding			ovary(1)	1		Ovarian(717;0.0129)		STAD - Stomach adenocarcinoma(1183;0.00159)|READ - Rectum adenocarcinoma(193;0.0419)		CATTACAGGGGAGCGTGTTCA	0.398		NaN											0	0	0	0.004482	0	9	25									
ARHGAP25	9938	broad.mit.edu	37	2	69046289	69046289	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:69046289G>C	uc002seu.2	+	9	1399	c.1035G>C	c.(1033-1035)ATG>ATC	p.M345I	ARHGAP25_uc010fdg.2_Missense_Mutation_p.M346I|ARHGAP25_uc010yql.1_Missense_Mutation_p.M306I|ARHGAP25_uc002sev.2_Missense_Mutation_p.M339I|ARHGAP25_uc002sew.2_Missense_Mutation_p.M338I|ARHGAP25_uc002sex.2_Missense_Mutation_p.M339I|ARHGAP25_uc002sey.2_Missense_Mutation_p.M72I	NM_001007231	NP_001007232	P42331	RHG25_HUMAN	Rho GTPase activating protein 25 isoform a	345	Rho-GAP.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(2)|breast(2)	4						TGACTATGATGATCAGAGACC	0.498		NaN											0	0	0	0.01441	0	54	95									
SMPD4	55627	broad.mit.edu	37	2	130910919	130910919	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:130910919G>A	uc002tqq.1	-	18	2635	c.2115C>T	c.(2113-2115)CTC>CTT	p.L705L	SMPD4_uc002tqo.1_Silent_p.L237L|SMPD4_uc002tqp.1_Silent_p.L444L|SMPD4_uc010yzy.1_Silent_p.L454L|SMPD4_uc010yzz.1_Silent_p.L369L|SMPD4_uc002tqr.1_Silent_p.L676L|SMPD4_uc002tqs.1_Silent_p.L573L|SMPD4_uc002tqt.1_Silent_p.L554L|SMPD4_uc010zaa.1_Silent_p.L563L|SMPD4_uc010zab.1_Silent_p.L603L|SMPD4_uc010zac.1_Silent_p.L446L|SMPD4_uc010zad.1_Silent_p.L341L	NM_017951	NP_060421	Q9NXE4	NSMA3_HUMAN	sphingomyelin phosphodiesterase 4 isoform 2	666					sphingomyelin catabolic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|trans-Golgi network	metal ion binding|protein binding|sphingomyelin phosphodiesterase activity|sphingomyelin phosphodiesterase D activity				0	Colorectal(110;0.1)				Phosphatidylserine(DB00144)	GCGTAAGGATGAGTCCGTCCT	0.642		NaN											0	0	0	0.013537	0	13	28									
RAB3GAP1	22930	broad.mit.edu	37	2	135911282	135911282	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:135911282G>A	uc002tuj.2	+	19	2150	c.2125G>A	c.(2125-2127)GAA>AAA	p.E709K	RAB3GAP1_uc010fnf.2_Missense_Mutation_p.E709K|RAB3GAP1_uc010fng.2_Missense_Mutation_p.E534K|RAB3GAP1_uc010fnh.1_RNA	NM_012233	NP_036365	Q15042	RB3GP_HUMAN	RAB3 GTPase-activating protein	709						centrosome|nucleus|soluble fraction	Rab GTPase activator activity|Rab GTPase binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(221;0.117)		GGATTATATTGAAGAGGAGGT	0.438		NaN											0	0	0	0.012319	0	22	48									
ARL6IP6	151188	broad.mit.edu	37	2	153575496	153575496	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:153575496C>G	uc002tyn.2	+	1	1074	c.358C>G	c.(358-360)CTT>GTT	p.L120V	ARL6IP6_uc002tym.2_Intron|ARL6IP6_uc002tyo.2_5'Flank|PRPF40A_uc002tyh.3_5'Flank|PRPF40A_uc010zcd.1_5'Flank|PRPF40A_uc002tyi.2_5'Flank|PRPF40A_uc002tyj.2_5'Flank|PRPF40A_uc002tyl.1_5'Flank	NM_152522	NP_689735	Q8N6S5	AR6P6_HUMAN	ADP-ribosylation-like factor 6 interacting	120	Helical; (Potential).					integral to membrane					0						CTTCGCCATTCTTCTCGCCTT	0.592		NaN											0	0	0	0.00499	0	15	41									
GRB14	2888	broad.mit.edu	37	2	165404308	165404308	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:165404308C>T	uc002ucl.2	-	3	884	c.343G>A	c.(343-345)GAA>AAA	p.E115K	GRB14_uc010zcv.1_Missense_Mutation_p.E28K|GRB14_uc002ucm.2_RNA	NM_004490	NP_004481	Q14449	GRB14_HUMAN	growth factor receptor-bound protein 14	115	Ras-associating.				blood coagulation|leukocyte migration	cytosol|endosome membrane|Golgi membrane|microsome|plasma membrane	SH3/SH2 adaptor activity			ovary(5)|upper_aerodigestive_tract(1)|lung(1)	7						GTTTCATCTTCACTGTATACT	0.328		NaN											0	0	0	0.004482	0	9	24									
RAPGEF4	11069	broad.mit.edu	37	2	173891911	173891911	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:173891911G>A	uc002uhv.3	+	25	2669	c.2482G>A	c.(2482-2484)GTC>ATC	p.V828I	RAPGEF4_uc002uhw.3_Missense_Mutation_p.V684I	NM_007023	NP_008954	Q8WZA2	RPGF4_HUMAN	Rap guanine nucleotide exchange factor (GEF) 4	828	Ras-GEF.				blood coagulation|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of insulin secretion|regulation of protein phosphorylation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cAMP-dependent protein kinase complex|membrane fraction|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity|Ras GTPase binding|Ras guanyl-nucleotide exchange factor activity			large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.194)			GTTTTGGGTCGTCACTGAGAT	0.368		NaN											0	0	0	0.006122	0	18	37									
TTN	7273	broad.mit.edu	37	2	179455032	179455032	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:179455032G>A	uc010zfg.1	-	253	53940	c.53716C>T	c.(53716-53718)CCA>TCA	p.P17906S	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P11601S|TTN_uc010zfi.1_Missense_Mutation_p.P11534S|TTN_uc010zfj.1_Missense_Mutation_p.P11409S	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	18833							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTACTTCTGGAGGATGAAGG	0.428		NaN											0	0	0	0.00632	0	29	62									
NCKAP1	10787	broad.mit.edu	37	2	183800087	183800087	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:183800087C>G	uc002upc.2	-	25	3114	c.2712G>C	c.(2710-2712)TTG>TTC	p.L904F	NCKAP1_uc002upb.2_Missense_Mutation_p.L910F	NM_013436	NP_038464	Q9Y2A7	NCKP1_HUMAN	NCK-associated protein 1 isoform 1	904					apoptosis|central nervous system development	integral to membrane|lamellipodium membrane	protein binding			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0942)|Epithelial(96;0.209)			TCATCCTCTTCAAGACACTGT	0.328		NaN											0	0	0	0.012319	0	22	31									
ZNF804A	91752	broad.mit.edu	37	2	185803013	185803013	+	Missense_Mutation	SNP	T	T	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:185803013T>C	uc002uph.2	+	4	3484	c.2890T>C	c.(2890-2892)TCA>CCA	p.S964P		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	964						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						CTTTAGACAGTCACAGCCTAA	0.393		NaN											0	0	0	0.021523	0	26	65									
PLCL1	5334	broad.mit.edu	37	2	198948687	198948687	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:198948687C>T	uc010fsp.2	+	2	737	c.446C>T	c.(445-447)TCA>TTA	p.S149L	PLCL1_uc002uuv.3_Missense_Mutation_p.S70L	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	149	PH.|Interaction with PPP1C.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	TGGGAACCTTCAAAGAAAGAC	0.448		NaN											0	0	0	0.008871	0	19	40									
FAM126B	285172	broad.mit.edu	37	2	201873710	201873710	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr2:201873710G>A	uc002uws.3	-	7	704	c.516C>T	c.(514-516)TTC>TTT	p.F172F	FAM126B_uc002uwu.2_Silent_p.F90F|FAM126B_uc002uwv.2_Silent_p.F172F|FAM126B_uc002uww.1_Silent_p.F172F	NM_173822	NP_776183	Q8IXS8	F126B_HUMAN	hypothetical protein LOC285172	172						intracellular				ovary(1)	1						TCTGTGCAGTGAATGTTTCCC	0.299		NaN											0	0	0	0.020292	0	14	29									
PANK2	80025	broad.mit.edu	37	20	3888748	3888748	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr20:3888748C>T	uc002wkc.2	+	2	810	c.804C>T	c.(802-804)CTC>CTT	p.L268L	PANK2_uc002wkb.2_5'UTR|PANK2_uc010gbd.1_RNA|PANK2_uc002wkd.2_RNA|PANK2_uc002wke.2_5'UTR|PANK2_uc002wkf.2_5'UTR	NM_153638	NP_705902	Q9BZ23	PANK2_HUMAN	pantothenate kinase 2 isoform 1 preproprotein	268					cell death|coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial intermembrane space|nucleus	ATP binding|pantothenate kinase activity|protein binding				0						ACGTGCACCTCGAGCTGAAGG	0.478		NaN											0	0	0	0.016723	0	14	59									
C20orf94	128710	broad.mit.edu	37	20	10603663	10603663	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr20:10603663G>A	uc010zre.1	+	8	1043	c.863G>A	c.(862-864)CGA>CAA	p.R288Q		NM_001009608	NP_001009608	Q5VYV7	CT094_HUMAN	hypothetical protein LOC128710	288							protein binding				0						CAAAGTCCACGAGTGGCCAAA	0.527		NaN											0	0	0	0.016522	0	22	46									
TTC3	7267	broad.mit.edu	37	21	38510991	38510991	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr21:38510991C>G	uc002yvz.2	+	19	1741	c.1636C>G	c.(1636-1638)CTC>GTC	p.L546V	TTC3_uc011aee.1_Missense_Mutation_p.L236V|TTC3_uc002ywa.2_Missense_Mutation_p.L546V|TTC3_uc002ywb.2_Missense_Mutation_p.L546V|TTC3_uc010gnf.2_Missense_Mutation_p.L311V|TTC3_uc002ywc.2_Missense_Mutation_p.L236V|TTC3_uc011aed.1_Missense_Mutation_p.L236V|TTC3_uc010gne.1_Missense_Mutation_p.L546V	NM_001001894	NP_001001894	P53804	TTC3_HUMAN	tetratricopeptide repeat domain 3	546	TPR 3.				protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	nucleus	protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(3)|ovary(2)|lung(2)|breast(2)	9		Myeloproliferative disorder(46;0.0412)				TGCCATTTCTCTCCTTGGAAT	0.308		NaN											0	0	0	0.012213	0	31	64									
UMODL1	89766	broad.mit.edu	37	21	43541202	43541202	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr21:43541202G>A	uc002zaf.1	+	16	2695	c.2695G>A	c.(2695-2697)GAT>AAT	p.D899N	UMODL1_uc002zad.1_Missense_Mutation_p.D827N|UMODL1_uc002zae.1_Missense_Mutation_p.D955N|UMODL1_uc002zag.1_Missense_Mutation_p.D1027N|UMODL1_uc002zal.1_5'UTR	NM_001004416	NP_001004416	Q5DID0	UROL1_HUMAN	uromodulin-like 1 isoform 1 precursor	899	Extracellular (Potential).|EGF-like 3; calcium-binding (Potential).					cytoplasm|extracellular region|integral to membrane|plasma membrane	calcium ion binding|peptidase inhibitor activity			ovary(2)|skin(1)	3						TGCAGATTACGATGAGTGTGA	0.537		NaN											0	0	0	0.010504	0	21	61									
COL18A1	80781	broad.mit.edu	37	21	46888254	46888254	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr21:46888254G>A	uc011afs.1	+	2	1471	c.1450G>A	c.(1450-1452)GTC>ATC	p.V484I	COL18A1_uc002zhg.2_Missense_Mutation_p.V69I|COL18A1_uc002zhi.2_Missense_Mutation_p.V249I	NM_130444	NP_569711	P39060	COIA1_HUMAN	alpha 1 type XVIII collagen isoform 3 precursor	484	TSP N-terminal.				cell adhesion|negative regulation of cell proliferation|organ morphogenesis|visual perception	collagen|extracellular space	extracellular matrix structural constituent|metal ion binding|protein binding			central_nervous_system(1)	1				Colorectal(79;0.0157)|READ - Rectum adenocarcinoma(84;0.0929)		GCTGGCCTACGTCTTTGGGCC	0.657		NaN											0	0	0	0.013726	0	32	53									
ARVCF	421	broad.mit.edu	37	22	19960296	19960296	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr22:19960296C>T	uc002zqz.2	-	16	2876	c.2605G>A	c.(2605-2607)GAT>AAT	p.D869N	ARVCF_uc002zqy.2_Missense_Mutation_p.D385N	NM_001670	NP_001661	O00192	ARVC_HUMAN	armadillo repeat protein	869					cell adhesion|multicellular organismal development		protein binding			liver(1)	1	Colorectal(54;0.0993)					GTGCTGTCATCGAAGCCCCCA	0.602		NaN											0	0	0	0.004482	0	9	26									
TRMT2A	27037	broad.mit.edu	37	22	20100722	20100722	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr22:20100722C>T	uc002zrk.1	-	11	1683	c.1468G>A	c.(1468-1470)GAG>AAG	p.E490K	TRMT2A_uc002zrl.1_Missense_Mutation_p.E490K|TRMT2A_uc002zrm.1_Missense_Mutation_p.E312K|TRMT2A_uc002zrn.1_Missense_Mutation_p.E508K	NM_182984	NP_892029	Q8IZ69	TRM2A_HUMAN	HpaII tiny fragments locus 9C	490					RNA processing		nucleotide binding|RNA binding|RNA methyltransferase activity			breast(1)	1						ACCAGGTCCTCGGCCCTCCCG	0.647		NaN											0	0	0	0.007413	0	19	21									
RTDR1	27156	broad.mit.edu	37	22	23406202	23406202	+	Silent	SNP	G	G	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr22:23406202G>T	uc002zwt.2	-	5	689	c.531C>A	c.(529-531)CTC>CTA	p.L177L		NM_014433	NP_055248	Q9UHP6	RTDR1_HUMAN	rhabdoid tumor deletion region protein 1	177							binding			ovary(1)	1	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.175)		CCTGCAGGCAGAGGACCAGTG	0.582		NaN											1	0	2.0095e-06	0.001984	2.09191e-06	7	16									
DNAL4	10126	broad.mit.edu	37	22	39178724	39178724	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr22:39178724C>G	uc003awj.2	-	2	241	c.13G>C	c.(13-15)GAA>CAA	p.E5Q	SUN2_uc010gxr.1_Intron	NM_005740	NP_005731	O96015	DNAL4_HUMAN	dynein light chain 4, axonemal	5					microtubule-based movement|nerve growth factor receptor signaling pathway	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule|plasma membrane	ATPase activity, coupled|microtubule motor activity				0	Melanoma(58;0.04)					TTCTTCCCTTCTGTTTCTCCC	0.572		NaN											0	0	0	0.006214	0	10	30									
FAM118A	55007	broad.mit.edu	37	22	45728377	45728377	+	Missense_Mutation	SNP	G	G	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr22:45728377G>T	uc003bfz.3	+	7	1339	c.723G>T	c.(721-723)CAG>CAT	p.Q241H	FAM118A_uc003bga.3_Missense_Mutation_p.Q241H|FAM118A_uc011aqr.1_Missense_Mutation_p.Q59H	NM_001104595	NP_001098065	Q9NWS6	F118A_HUMAN	hypothetical protein LOC55007	241						integral to membrane					0		Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)		TTCGTGATCAGATATTCCAGG	0.463		NaN											1	0	3.78316e-11	0.025465	4.04027e-11	42	67									
BRD1	23774	broad.mit.edu	37	22	50187866	50187866	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr22:50187866G>A	uc003biv.2	-	6	2662	c.2175C>T	c.(2173-2175)CTC>CTT	p.L725L	BRD1_uc011arf.1_Silent_p.L320L|BRD1_uc011arg.1_Silent_p.L774L|BRD1_uc011arh.1_Silent_p.L725L|BRD1_uc003biu.3_Silent_p.L725L	NM_014577	NP_055392	O95696	BRD1_HUMAN	bromodomain containing protein 1	725					histone H3 acetylation	MOZ/MORF histone acetyltransferase complex	zinc ion binding			pancreas(1)	1		all_cancers(38;6.11e-10)|all_epithelial(38;8.06e-09)|all_lung(38;6.64e-05)|Lung NSC(38;0.0011)|Breast(42;0.00235)|Ovarian(80;0.0139)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0369)|BRCA - Breast invasive adenocarcinoma(115;0.21)		AGGTGAGGTCGAGCATGTCCA	0.597		NaN											0	0	0	0.006122	0	17	32									
PLXNB2	23654	broad.mit.edu	37	22	50727555	50727555	+	Missense_Mutation	SNP	A	A	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr22:50727555A>G	uc003bkv.3	-	4	1191	c.1085T>C	c.(1084-1086)TTC>TCC	p.F362S		NM_012401	NP_036533	O15031	PLXB2_HUMAN	plexin B2 precursor	362	Extracellular (Potential).|Sema.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity			ovary(4)|central_nervous_system(1)|skin(1)	6		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		GCCACATGGGAAGCTCTTGCT	0.687		NaN											0	0	0	0.004672	0	3	10									
GRM7	2917	broad.mit.edu	37	3	7503406	7503406	+	Silent	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:7503406C>G	uc003bqm.2	+	7	1786	c.1512C>G	c.(1510-1512)CTC>CTG	p.L504L	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Silent_p.L504L|GRM7_uc003bql.2_Silent_p.L504L|GRM7_uc003bqn.1_Silent_p.L87L|GRM7_uc010hch.1_5'UTR	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	504	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	AACTTCAGCTCAATGTGAGTT	0.443		NaN											0	0	0	0.008871	0	19	75									
C3orf20	84077	broad.mit.edu	37	3	14745900	14745900	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:14745900G>A	uc003byy.2	+	7	1339	c.935G>A	c.(934-936)CGA>CAA	p.R312Q	C3orf20_uc003byz.2_Missense_Mutation_p.R190Q|C3orf20_uc003bza.2_Missense_Mutation_p.R190Q|C3orf20_uc003byx.1_Intron	NM_032137	NP_115513	Q8ND61	CC020_HUMAN	hypothetical protein LOC84077	312						cytoplasm|integral to membrane				ovary(3)|skin(1)	4						ATGATCTTACGAAACTACAAG	0.493		NaN											0	0	0	0.024334	0	27	76									
TRIM71	131405	broad.mit.edu	37	3	32933231	32933231	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:32933231C>T	uc003cff.2	+	4	2598	c.2535C>T	c.(2533-2535)TCC>TCT	p.S845S		NM_001039111	NP_001034200	Q2Q1W2	LIN41_HUMAN	tripartite motif-containing 71	845	NHL 6.				multicellular organismal development	cytoplasm	zinc ion binding			ovary(2)|large_intestine(1)	3						ACCGCCCTTCCGGCATCGCCA	0.527		NaN											0	0	0	0.008361	0	29	121									
FBXL2	25827	broad.mit.edu	37	3	33416785	33416785	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:33416785C>T	uc003cfp.2	+	10	734	c.663C>T	c.(661-663)ATC>ATT	p.I221I	FBXL2_uc011axm.1_RNA|FBXL2_uc011axn.1_RNA|FBXL2_uc011axo.1_Silent_p.I116I|FBXL2_uc011axp.1_Silent_p.I137I|FBXL2_uc011axq.1_RNA|FBXL2_uc011axr.1_RNA|FBXL2_uc011axs.1_RNA	NM_012157	NP_036289	Q9UKC9	FBXL2_HUMAN	F-box and leucine-rich repeat protein 2	221	LRR 7.				interspecies interaction between organisms|proteolysis	cytoplasm|membrane	protein binding|ubiquitin-protein ligase activity			large_intestine(1)	1						CTCAGCGTATCACGGATGAAG	0.512		NaN											0	0	0	0.01441	0	48	35									
EPM2AIP1	9852	broad.mit.edu	37	3	37033161	37033161	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:37033161C>G	uc003cgk.2	-	1	1635	c.1408G>C	c.(1408-1410)GAA>CAA	p.E470Q	MLH1_uc011aye.1_5'Flank|MLH1_uc003cgl.2_5'Flank|MLH1_uc011ayb.1_5'Flank|MLH1_uc010hge.2_5'Flank|MLH1_uc003cgn.3_5'Flank|MLH1_uc011ayc.1_5'Flank|MLH1_uc011ayd.1_5'Flank|MLH1_uc003cgo.2_5'Flank	NM_014805	NP_055620	Q7L775	EPMIP_HUMAN	EPM2A interacting protein 1	470						endoplasmic reticulum					0						CTCTCAAATTCTTTTTGGAGA	0.328		NaN											0	0	0	0.006214	0	10	38									
IMPDH2	3615	broad.mit.edu	37	3	49062587	49062587	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:49062587C>T	uc003cvt.2	-	10	1214	c.1122G>A	c.(1120-1122)GCG>GCA	p.A374A		NM_000884	NP_000875	P12268	IMDH2_HUMAN	inosine monophosphate dehydrogenase 2	374					GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	IMP dehydrogenase activity|metal ion binding|nucleotide binding|protein binding			lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)	CCAAGGCTTTCGCAATATGAC	0.577		NaN											0	0	0	0.00632	0	30	23									
OR5H2	79310	broad.mit.edu	37	3	98002110	98002110	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:98002110C>T	uc003dsj.1	+	1	379	c.379C>T	c.(379-381)CGC>TGC	p.R127C		NM_001005482	NP_001005482	Q8NGV7	OR5H2_HUMAN	olfactory receptor, family 5, subfamily H,	127	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)	3						GGCATATGATCGCTATGTAGC	0.378		NaN											0	0	0	0.007291	0	31	99									
BTLA	151888	broad.mit.edu	37	3	112190070	112190070	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:112190070C>G	uc003dza.3	-	3	739	c.536G>C	c.(535-537)AGA>ACA	p.R179T	BTLA_uc003dzb.3_Intron	NM_181780	NP_861445	Q7Z6A9	BTLA_HUMAN	B and T lymphocyte associated isoform 1	179	Cytoplasmic (Potential).				T cell costimulation		receptor activity				0		Acute lymphoblastic leukemia(4;1.34e-07)|all_hematologic(4;0.000361)				TTGGTGCCTTCTCAGGCAGCA	0.493		NaN											0	0	0	0.024245	0	15	47									
GOLGB1	2804	broad.mit.edu	37	3	121396236	121396236	+	Missense_Mutation	SNP	T	T	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:121396236T>C	uc003eei.3	-	16	9046	c.8920A>G	c.(8920-8922)ATC>GTC	p.I2974V	GOLGB1_uc010hrc.2_Missense_Mutation_p.I2979V|GOLGB1_uc003eej.3_Missense_Mutation_p.I2940V	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	2974	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		TTATCTGAGATAGCCATAAGG	0.408		NaN											0	0	0	0.020292	0	14	61									
PDIA5	10954	broad.mit.edu	37	3	122849434	122849434	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:122849434C>T	uc003egc.1	+	11	937	c.881C>T	c.(880-882)TCC>TTC	p.S294F	PDIA5_uc003egd.1_Intron	NM_006810	NP_006801	Q14554	PDIA5_HUMAN	protein disulfide isomerase A5 precursor	294	Thioredoxin 2.				cell redox homeostasis|glycerol ether metabolic process|protein folding|response to stress	endoplasmic reticulum lumen	electron carrier activity|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.0427)		AAGGAACACTCCTCTGTCCTC	0.587		NaN											0	0	0	0.01441	0	43	32									
PLXNA1	5361	broad.mit.edu	37	3	126707544	126707544	+	Silent	SNP	T	T	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:126707544T>G	uc003ejg.2	+	1	43	c.39T>G	c.(37-39)GGT>GGG	p.G13G		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	36	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		CAGGCGGGGGTTCACAGCCCC	0.567		NaN											0	0	0	0.00499	0	13	20									
PLXNA1	5361	broad.mit.edu	37	3	126708282	126708282	+	Silent	SNP	C	C	T	rs146246704		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:126708282C>T	uc003ejg.2	+	1	781	c.777C>T	c.(775-777)ATC>ATT	p.I259I		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	282	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		CGTCCAAGATCGTGCGGCTCT	0.602		NaN											0	0	0	0.01441	0	50	138									
MECOM	2122	broad.mit.edu	37	3	168840502	168840502	+	Missense_Mutation	SNP	T	T	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr3:168840502T>G	uc003ffi.3	-	5	549	c.280A>C	c.(280-282)ATG>CTG	p.M94L	MECOM_uc010hwk.1_Missense_Mutation_p.M117L|MECOM_uc003ffj.3_Missense_Mutation_p.M158L|MECOM_uc011bpi.1_Missense_Mutation_p.M94L|MECOM_uc003ffn.3_Missense_Mutation_p.M94L|MECOM_uc003ffk.2_Missense_Mutation_p.M94L|MECOM_uc003ffl.2_Missense_Mutation_p.M254L|MECOM_uc011bpj.1_Missense_Mutation_p.M282L|MECOM_uc011bpk.1_Missense_Mutation_p.M84L|MECOM_uc010hwn.2_Missense_Mutation_p.M282L|MECOM_uc003ffm.1_Missense_Mutation_p.M158L	NM_005241	NP_005232	Q03112	EVI1_HUMAN	MDS1 and EVI1 complex locus isoform b	94	Interaction with MAPK9, SMAD3 and probably SUV39H1.|C2H2-type 2.				apoptosis|cell differentiation|hemopoietic stem cell proliferation|negative regulation of JNK cascade|negative regulation of programmed cell death|negative regulation of transcription, DNA-dependent|regulation of cell cycle	nuclear speck	DNA binding|protein binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(5)|skin(5)|upper_aerodigestive_tract(1)|central_nervous_system(1)|ovary(1)|pancreas(1)	14						TGTGACAGCATGTGTTTCTCC	0.373		NaN											0	0	0	0.017118	0	36	27									
HTRA3	94031	broad.mit.edu	37	4	8288376	8288376	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr4:8288376G>A	uc003gla.2	+	3	778	c.574G>A	c.(574-576)GTG>ATG	p.V192M	HTRA3_uc003gkz.2_Missense_Mutation_p.V192M	NM_053044	NP_444272	P83110	HTRA3_HUMAN	HtrA serine peptidase 3 precursor	192	Serine protease.				proteolysis|regulation of cell growth	extracellular region	insulin-like growth factor binding|serine-type endopeptidase activity			ovary(1)	1						CAATGCCCACGTGGTGTCCAG	0.602		NaN											0	0	0	0.024334	0	28	34									
BEND4	389206	broad.mit.edu	37	4	42145579	42145579	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr4:42145579G>A	uc003gwn.2	-	3	1500	c.920C>T	c.(919-921)TCA>TTA	p.S307L	BEND4_uc003gwm.2_Missense_Mutation_p.S307L|BEND4_uc011byy.1_Missense_Mutation_p.S307L	NM_207406	NP_997289	Q6ZU67	BEND4_HUMAN	BEN domain containing 4 isoform a	307											0						CAGTGTAGATGAAGATGGGTG	0.463		NaN											0	0	0	0.009096	0	4	3									
TMEM165	55858	broad.mit.edu	37	4	56284049	56284049	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr4:56284049T>A	uc003hax.2	+	4	956	c.689T>A	c.(688-690)TTG>TAG	p.L230*	TMEM165_uc011bzy.1_Nonsense_Mutation_p.L167*	NM_018475	NP_060945	Q9HC07	TM165_HUMAN	transmembrane protein 165	230	Helical; (Potential).					integral to membrane					0	Lung NSC(11;0.00545)|Glioma(25;0.08)|all_neural(26;0.101)|all_epithelial(27;0.135)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0103)			AAAAAGTGGTTGCATTTTATT	0.353		NaN											0	0	0	0.004672	0	3	27									
METTL14	57721	broad.mit.edu	37	4	119613186	119613186	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr4:119613186C>A	uc003icf.2	+	5	491	c.375C>A	c.(373-375)GAC>GAA	p.D125E	METTL14_uc003icg.2_Missense_Mutation_p.D87E	NM_020961	NP_066012	Q9HCE5	MTL14_HUMAN	methyltransferase like 14	125						nucleus	mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity				0						ATTTTGTAGACACTGGACATA	0.353		NaN											1	0	1.96895e-08	0.016522	2.06928e-08	22	59									
CLGN	1047	broad.mit.edu	37	4	141310427	141310427	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr4:141310427C>T	uc011chi.1	-	16	2002	c.1784G>A	c.(1783-1785)GGA>GAA	p.G595E	CLGN_uc003iii.2_Missense_Mutation_p.G595E	NM_001130675	NP_001124147	O14967	CLGN_HUMAN	calmegin precursor	595	Cytoplasmic (Potential).				protein folding	endoplasmic reticulum membrane|integral to membrane	calcium ion binding|unfolded protein binding			ovary(2)|skin(1)	3	all_hematologic(180;0.162)					CGGCCCATCTCCAGATCCTGT	0.333		NaN											0	0	0	0.006214	0	10	50									
LRBA	987	broad.mit.edu	37	4	151773605	151773605	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr4:151773605G>A	uc010ipj.2	-	23	3731	c.3257C>T	c.(3256-3258)TCA>TTA	p.S1086L	LRBA_uc003ilt.3_5'Flank|LRBA_uc003ilu.3_Missense_Mutation_p.S1086L	NM_006726	NP_006717	P50851	LRBA_HUMAN	LPS-responsive vesicle trafficking, beach and	1086						endoplasmic reticulum|Golgi apparatus|integral to membrane|lysosome|plasma membrane	protein binding			ovary(3)|breast(3)|skin(1)	7	all_hematologic(180;0.151)					ATCCTCTTCTGAAGGAGAACT	0.383		NaN											0	0	0	0.013537	0	13	51									
SDHA	6389	broad.mit.edu	37	5	224526	224527	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:224526_224527GG>TT	uc003jao.3	+	3	317_318	c.202_203GG>TT	c.(202-204)GGC>TTC	p.G68F	SDHA_uc003jan.2_Missense_Mutation_p.G68F|SDHA_uc011clv.1_Missense_Mutation_p.G68F|SDHA_uc011clw.1_Missense_Mutation_p.G68F|SDHA_uc003jap.3_Missense_Mutation_p.G68F	NM_004168	NP_004159	P31040	DHSA_HUMAN	succinate dehydrogenase complex, subunit A,	68	FAD (By similarity).				nervous system development|respiratory electron transport chain|succinate metabolic process|transport|tricarboxylic acid cycle	mitochondrial respiratory chain complex II	electron carrier activity|flavin adenine dinucleotide binding|protein binding|succinate dehydrogenase (ubiquinone) activity				0			Epithelial(17;0.0159)|all cancers(22;0.0236)|OV - Ovarian serous cystadenocarcinoma(19;0.0674)|Lung(60;0.113)		Succinic acid(DB00139)	AGTGGTGGTAGGCGCTGGAGGG	0.47		NaN							Familial_Paragangliomas				0	0	0	0.004672	0	50	78									
TRIO	7204	broad.mit.edu	37	5	14358313	14358313	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:14358313G>A	uc003jff.2	+	12	2079	c.2073G>A	c.(2071-2073)CAG>CAA	p.Q691Q	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Silent_p.Q642Q|TRIO_uc003jfh.1_Silent_p.Q340Q	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	691					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					AGGAGCTGCAGAAGGAGCTGC	0.687		NaN											0	0	0	0.00308	0	8	17									
BASP1	10409	broad.mit.edu	37	5	17275374	17275374	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:17275374G>A	uc003jfx.2	+	2	228	c.49G>A	c.(49-51)GAG>AAG	p.E17K		NM_006317	NP_006308	P80723	BASP1_HUMAN	brain abundant, membrane attached signal protein	17					glomerular visceral epithelial cell differentiation|negative regulation of transcription, DNA-dependent	cytoplasm|cytoskeleton|growth cone|nuclear speck|plasma membrane	protein domain specific binding|transcription corepressor activity|transcription regulatory region DNA binding				0						TGTGAACGACGAGAAAGCCAA	0.577		NaN											0	0	0	0.00308	0	7	15									
C5orf42	65250	broad.mit.edu	37	5	37154070	37154070	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:37154070G>C	uc011cpa.1	-	41	8214	c.7983C>G	c.(7981-7983)TTC>TTG	p.F2661L	C5orf42_uc003jkp.1_RNA|C5orf42_uc011coy.1_Missense_Mutation_p.F1179L|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Missense_Mutation_p.F1754L	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	2661										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			TCTGTCCTTTGAATCGGAACT	0.393		NaN											0	0	0	0.012319	0	22	27									
MAST4	375449	broad.mit.edu	37	5	66460281	66460281	+	Silent	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:66460281C>G	uc003jut.1	+	28	4775	c.4707C>G	c.(4705-4707)CTC>CTG	p.L1569L	MAST4_uc003juw.2_Silent_p.L1497L|MAST4_uc003jux.2_5'Flank	NM_015183	NP_055998	O15021	MAST4_HUMAN	microtubule associated serine/threonine kinase	1761						cytoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(6)|ovary(2)|kidney(2)|breast(2)|central_nervous_system(1)	13		Lung NSC(167;8.56e-06)|Prostate(74;0.00637)|Ovarian(174;0.0563)|Breast(144;0.0586)|Colorectal(97;0.245)		Lung(70;0.011)		TTGTTCCCCTCAAGGCCTTAA	0.607		NaN											0	0	0	0.024245	0	15	35									
OCLN	4950	broad.mit.edu	37	5	68805528	68805528	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:68805528C>G	uc003jwu.2	+	3	1047	c.611C>G	c.(610-612)TCT>TGT	p.S204C	OCLN_uc003jwv.3_Missense_Mutation_p.S204C	NM_002538	NP_002529			occludin												0		Lung NSC(167;4.15e-05)|Prostate(74;0.00996)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;3.04e-60)|Epithelial(20;7.09e-58)|all cancers(19;1.13e-53)|Lung(70;0.0174)		GCTCAGTCTTCTGGATCTCTA	0.403		NaN											0	0	0	0.01441	0	64	115									
WDR41	55255	broad.mit.edu	37	5	76732192	76732192	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:76732192C>A	uc003kff.1	-	12	1408	c.1121G>T	c.(1120-1122)AGA>ATA	p.R374I	WDR41_uc011csy.1_Missense_Mutation_p.R316I|WDR41_uc011csz.1_Missense_Mutation_p.R319I	NM_018268	NP_060738	Q9HAD4	WDR41_HUMAN	WD repeat domain 41	374											0		all_lung(232;0.000961)|Lung NSC(167;0.0011)|Ovarian(174;0.0105)|Prostate(461;0.059)		OV - Ovarian serous cystadenocarcinoma(54;6.3e-50)|Epithelial(54;2.04e-44)|all cancers(79;6.84e-40)		TTTGCTGACTCTTCCAAATCC	0.353		NaN											1	0	9.16793e-09	0.00499	9.66587e-09	17	36									
ANKRD32	84250	broad.mit.edu	37	5	94030836	94030836	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:94030836C>A	uc003kkr.3	+	21	3076	c.2996C>A	c.(2995-2997)ACC>AAC	p.T999N	ANKRD32_uc003kks.2_Missense_Mutation_p.T363N	NM_032290	NP_115666	Q9BQI6	ANR32_HUMAN	ankyrin repeat domain 32	999										ovary(2)	2		all_cancers(142;1.51e-09)|all_epithelial(76;4.68e-12)|all_lung(232;5.94e-05)|Ovarian(174;0.000953)|Lung NSC(167;0.00105)|Colorectal(57;0.122)|Lung SC(612;0.152)		all cancers(79;3.88e-18)		CATAAAGAAACCACCAGTGTT	0.348		NaN											1	0	2.32078e-09	0.024245	2.45468e-09	11	60									
TSLP	85480	broad.mit.edu	37	5	110407681	110407681	+	Silent	SNP	C	C	T	rs148498768	byFrequency	TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:110407681C>T	uc003kpb.2	+	1	292	c.93C>T	c.(91-93)TTC>TTT	p.F31F	TSLP_uc003kpa.2_RNA|TSLP_uc010jbt.1_5'Flank	NM_033035	NP_149024	Q969D9	TSLP_HUMAN	thymic stromal lymphopoietin isoform 1	31						extracellular space	cytokine activity				0		all_cancers(142;2.72e-05)|all_epithelial(76;4.39e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0417)|Ovarian(225;0.0443)|Colorectal(57;0.0464)|all_lung(232;0.0507)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.24e-08)|Epithelial(69;1.54e-07)|all cancers(49;1.73e-05)|COAD - Colon adenocarcinoma(37;0.109)		CTTACGACTTCACTAACTGTG	0.368		NaN											0	0	0	0.027894	0	40	44									
STARD4	134429	broad.mit.edu	37	5	110835670	110835670	+	Missense_Mutation	SNP	G	G	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:110835670G>T	uc003kph.1	-	6	616	c.532C>A	c.(532-534)CGT>AGT	p.R178S	STARD4_uc010jbw.1_Missense_Mutation_p.R80S|STARD4_uc010jbx.1_Missense_Mutation_p.R80S|STARD4_uc003kpi.1_RNA	NM_139164	NP_631903	Q96DR4	STAR4_HUMAN	StAR-related lipid transfer (START) domain	178	START.				lipid transport		lipid binding			ovary(1)	1		all_cancers(142;0.00259)|all_epithelial(76;8.32e-05)|Prostate(80;0.0115)|Colorectal(10;0.0959)|Ovarian(225;0.156)|all_lung(232;0.18)|Lung NSC(167;0.248)		OV - Ovarian serous cystadenocarcinoma(64;4.91e-09)|Epithelial(69;1.39e-08)|all cancers(49;2.34e-06)|COAD - Colon adenocarcinoma(37;0.049)|Colorectal(14;0.138)		ATCATCCCACGCAGATCTGTC	0.413		NaN											1	0	7.92952e-12	0.021523	8.52359e-12	26	43									
SNCAIP	9627	broad.mit.edu	37	5	121759024	121759024	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:121759024G>A	uc003ksw.1	+	4	798	c.592G>A	c.(592-594)GAG>AAG	p.E198K	SNCAIP_uc011cwl.1_Intron|SNCAIP_uc010jct.2_Missense_Mutation_p.E198K|SNCAIP_uc003ksx.1_Missense_Mutation_p.E245K|SNCAIP_uc003ksy.1_Intron|SNCAIP_uc003ksz.1_Intron|SNCAIP_uc010jcu.2_Intron|SNCAIP_uc011cwm.1_Intron|SNCAIP_uc003kta.1_Intron|SNCAIP_uc010jcv.1_RNA|SNCAIP_uc010jcw.1_Intron|SNCAIP_uc010jcx.1_Missense_Mutation_p.E198K	NM_005460	NP_005451	Q9Y6H5	SNCAP_HUMAN	synuclein alpha interacting protein	198					cell death|dopamine metabolic process|regulation of inclusion body assembly|regulation of neurotransmitter secretion	cytoplasm|neuronal cell body|nucleolus|presynaptic membrane	ubiquitin protein ligase binding			ovary(1)|pancreas(1)	2		all_cancers(142;0.00787)|Prostate(80;0.0327)	KIRC - Kidney renal clear cell carcinoma(527;0.206)	OV - Ovarian serous cystadenocarcinoma(64;0.000625)|Epithelial(69;0.00216)|all cancers(49;0.0232)		AGGAAGTTCTGAGAGCTCATC	0.463		NaN											0	0	0	0.012213	0	33	61									
FBN2	2201	broad.mit.edu	37	5	127614405	127614405	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:127614405C>G	uc003kuu.2	-	57	7706	c.7267G>C	c.(7267-7269)GAG>CAG	p.E2423Q		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	2423	TB 9.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		GGGCAAAGCTCGCACTGGTGG	0.493		NaN											0	0	0	0.006122	0	19	46									
PCDHB1	29930	broad.mit.edu	37	5	140433360	140433360	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:140433360C>G	uc003lik.1	+	1	2382	c.2305C>G	c.(2305-2307)CGC>GGC	p.R769G		NM_013340	NP_037472	Q9Y5F3	PCDB1_HUMAN	protocadherin beta 1 precursor	769	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TAGTGAGTTTCGCTTTCTTAA	0.463		NaN											0	0	0	0.007291	0	29	66									
PCDHB6	56130	broad.mit.edu	37	5	140530412	140530412	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:140530412G>C	uc003lir.2	+	1	574	c.574G>C	c.(574-576)GAG>CAG	p.E192Q	PCDHB6_uc011dah.1_Missense_Mutation_p.E56Q	NM_018939	NP_061762	Q9Y5E3	PCDB6_HUMAN	protocadherin beta 6 precursor	192	Cadherin 2.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAAGTTCCCGGAGCTGGTGCT	0.617		NaN											0	0	0	0.00874	0	43	62									
GABRG2	2566	broad.mit.edu	37	5	161528316	161528316	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:161528316C>T	uc003lyz.3	+	5	982	c.624C>T	c.(622-624)TTC>TTT	p.F208F	GABRG2_uc010jjc.2_Silent_p.F208F|GABRG2_uc003lyy.3_Silent_p.F208F|GABRG2_uc011dej.1_Silent_p.F113F	NM_000816	NP_000807	P18507	GBRG2_HUMAN	gamma-aminobutyric acid A receptor, gamma 2	208	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(4)|skin(1)	5	Renal(175;0.000319)	Medulloblastoma(196;0.0208)|all_neural(177;0.0672)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0734)|OV - Ovarian serous cystadenocarcinoma(192;0.135)|Epithelial(171;0.136)		CCTTGGAGTTCTCCAGTTGTA	0.363		NaN											0	0	0	0.013537	0	10	11									
UNC5A	90249	broad.mit.edu	37	5	176306326	176306326	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:176306326G>C	uc003mey.2	+	14	2392	c.2200G>C	c.(2200-2202)GAG>CAG	p.E734Q		NM_133369	NP_588610	Q6ZN44	UNC5A_HUMAN	netrin receptor Unc5h1 precursor	734	Cytoplasmic (Potential).				apoptosis|axon guidance|regulation of apoptosis	integral to membrane|plasma membrane				skin(1)	1	all_cancers(89;0.000119)|Renal(175;0.000269)|Lung NSC(126;0.00696)|all_lung(126;0.0115)	Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			AAGGTTTGCTGAGCTGCTGGC	0.617		NaN											0	0	0	0.024334	0	25	60									
FLT4	2324	broad.mit.edu	37	5	180041110	180041110	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr5:180041110C>T	uc003mma.3	-	24	3368	c.3289G>A	c.(3289-3291)GTG>ATG	p.V1097M	FLT4_uc003mlz.3_Missense_Mutation_p.V1097M	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	1097	Cytoplasmic (Potential).|Protein kinase.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	AAGGACCACACGTCACTCTGC	0.622		NaN							Congenital_Hereditary_Lymphedema				0	0	0	0.00499	0	15	36									
SERPINB6	5269	broad.mit.edu	37	6	2948867	2948867	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:2948867C>T	uc003muk.2	-	6	2791	c.796G>A	c.(796-798)GAG>AAG	p.E266K	SERPINB6_uc003mui.2_Missense_Mutation_p.E149K|SERPINB6_uc003muj.2_RNA|SERPINB6_uc003mul.2_Missense_Mutation_p.E266K|SERPINB6_uc003mum.2_Missense_Mutation_p.E266K|SERPINB6_uc003mun.2_Missense_Mutation_p.E266K|SERPINB6_uc003muo.2_Missense_Mutation_p.E266K	NM_004568	NP_004559	P35237	SPB6_HUMAN	serine (or cysteine) proteinase inhibitor, clade	266					regulation of proteolysis	centrosome|cytosol|protein complex	protease binding|serine-type endopeptidase inhibitor activity				0	Ovarian(93;0.0412)	all_hematologic(90;0.0895)			Drotrecogin alfa(DB00055)	ACTTCCACCTCCTCTTCATCC	0.517		NaN											0	0	0	0.01441	0	56	122									
DSP	1832	broad.mit.edu	37	6	7575714	7575714	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:7575714G>C	uc003mxp.1	+	18	2902	c.2623G>C	c.(2623-2625)GAC>CAC	p.D875H	DSP_uc003mxq.1_Missense_Mutation_p.D875H	NM_004415	NP_004406	P15924	DESP_HUMAN	desmoplakin isoform I	875	Globular 1.|Spectrin 2.				cellular component disassembly involved in apoptosis|keratinocyte differentiation|peptide cross-linking	cornified envelope|cytoplasm|desmosome	protein binding, bridging|structural constituent of cytoskeleton			central_nervous_system(6)|ovary(2)|skin(1)	9	Ovarian(93;0.0584)	all_hematologic(90;0.236)		OV - Ovarian serous cystadenocarcinoma(45;0.000508)		TAAACAGATCGACTTTAGGTA	0.473		NaN											0	0	0	0.016723	0	13	34									
HIST1H1C	3006	broad.mit.edu	37	6	26056108	26056108	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:26056108C>G	uc003nfw.2	-	1	592	c.549G>C	c.(547-549)AAG>AAC	p.K183N		NM_005319	NP_005310	P16403	H12_HUMAN	histone cluster 1, H1c	183					nucleosome assembly	nucleosome|nucleus	DNA binding			ovary(3)|skin(2)	5						TGGCAGCTTTCTTGGGCTTCG	0.552		NaN											0	0	0	0.007291	0	30	52									
TRIM31	11074	broad.mit.edu	37	6	30080495	30080495	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:30080495C>T	uc003npg.1	-	2	198	c.88G>A	c.(88-90)GAC>AAC	p.D30N	TRIM31_uc003npi.3_RNA	NM_007028	NP_008959	Q9BZY9	TRI31_HUMAN	tripartite motif protein 31	30	RING-type.					mitochondrion	ligase activity|zinc ion binding			lung(1)	1						TGCCCACAGTCGATGGTGACA	0.473		NaN											0	0	0	0.024334	0	27	57									
VARS2	57176	broad.mit.edu	37	6	30891140	30891140	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:30891140C>A	uc003nsc.1	+	24	2956	c.2324C>A	c.(2323-2325)TCC>TAC	p.S775Y	VARS2_uc011dmx.1_Missense_Mutation_p.S775Y|VARS2_uc011dmy.1_Missense_Mutation_p.S635Y|VARS2_uc011dmz.1_Missense_Mutation_p.S805Y|VARS2_uc011dna.1_Missense_Mutation_p.S773Y|VARS2_uc011dnb.1_RNA|VARS2_uc011dnc.1_RNA|VARS2_uc011dnd.1_Missense_Mutation_p.S213Y|VARS2_uc010jsg.1_Missense_Mutation_p.S147Y|VARS2_uc010jsh.1_5'UTR	NM_020442	NP_065175	Q5ST30	SYVM_HUMAN	valyl-tRNA synthetase 2, mitochondrial	775					valyl-tRNA aminoacylation	mitochondrion	ATP binding|valine-tRNA ligase activity			ovary(3)|central_nervous_system(1)	4						CTGTCTCCCTCCTCCCCGATG	0.657		NaN											1	0	1.08611e-07	0.010729	1.13783e-07	12	30									
DNAH8	1769	broad.mit.edu	37	6	38941567	38941567	+	Missense_Mutation	SNP	G	G	A	rs144808884	byFrequency	TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:38941567G>A	uc003ooe.1	+	82	12605	c.12005G>A	c.(12004-12006)CGA>CAA	p.R4002Q	DNAH8_uc003oog.1_Missense_Mutation_p.R451Q	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						CCCCATGATCGATTTCCAATT	0.393		NaN											0	0	0	0.016723	0	12	24									
SLC22A7	10864	broad.mit.edu	37	6	43266487	43266487	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:43266487G>C	uc003out.2	+	1	490	c.391G>C	c.(391-393)GAG>CAG	p.E131Q	SLC22A7_uc010jyl.1_Missense_Mutation_p.E131Q|SLC22A7_uc003ous.2_Missense_Mutation_p.E131Q	NM_153320	NP_696961	Q9Y694	S22A7_HUMAN	solute carrier family 22 member 7 isoform b	131						basolateral plasma membrane|integral to plasma membrane|membrane fraction	anion:anion antiporter activity|sodium-independent organic anion transmembrane transporter activity				0			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00998)|OV - Ovarian serous cystadenocarcinoma(102;0.0305)			CATTGCAACTGAGGTACTTAA	0.468		NaN											0	0	0	0.010729	0	10	24									
GRIK2	2898	broad.mit.edu	37	6	102516372	102516372	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:102516372G>C	uc003pqp.3	+	16	2962	c.2713G>C	c.(2713-2715)GAA>CAA	p.E905Q	GRIK2_uc003pqo.3_3'UTR|GRIK2_uc010kcw.2_3'UTR	NM_021956	NP_068775	Q13002	GRIK2_HUMAN	glutamate receptor, ionotropic, kainate 2	905	Cytoplasmic (Potential).				glutamate signaling pathway|induction of programmed cell death in response to chemical stimulus|neuron apoptosis|positive regulation of synaptic transmission|regulation of short-term neuronal synaptic plasticity	cell junction|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|kainate selective glutamate receptor activity			ovary(2)|pancreas(1)|breast(1)|skin(1)	5		all_cancers(76;1.19e-07)|Acute lymphoblastic leukemia(125;6.17e-11)|all_hematologic(75;6.01e-08)|all_epithelial(87;0.0121)|Colorectal(196;0.14)		all cancers(137;0.112)|BRCA - Breast invasive adenocarcinoma(108;0.124)|GBM - Glioblastoma multiforme(226;0.206)	L-Glutamic Acid(DB00142)	GCCAGGTAAAGAAACCATGGC	0.433		NaN											0	0	0	0.006214	0	9	25									
TPD52L1	7164	broad.mit.edu	37	6	125578274	125578274	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:125578274G>A	uc003pzu.1	+	6	675	c.456G>A	c.(454-456)GAG>GAA	p.E152E	TPD52L1_uc003pzv.1_Intron|TPD52L1_uc003pzw.1_Intron|TPD52L1_uc003pzy.1_Silent_p.E123E|TPD52L1_uc003pzz.1_Intron	NM_003287	NP_003278	Q16890	TPD53_HUMAN	tumor protein D52-like 1 isoform 1	152					DNA fragmentation involved in apoptotic nuclear change|G2/M transition of mitotic cell cycle|induction of apoptosis|positive regulation of JNK cascade|positive regulation of MAP kinase activity	perinuclear region of cytoplasm	caspase activator activity|protein heterodimerization activity|protein homodimerization activity				0			LUSC - Lung squamous cell carcinoma(4;0.0263)|Lung(4;0.0828)	GBM - Glioblastoma multiforme(226;0.0265)		CATTTGAGGAGAGGGTTGAGA	0.443		NaN											0	0	0	0.004482	0	8	23									
CCDC28A	25901	broad.mit.edu	37	6	139106381	139106381	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:139106381G>A	uc003qie.2	+	4	765	c.610G>A	c.(610-612)GAA>AAA	p.E204K		NM_015439	NP_056254	Q8IWP9	CC28A_HUMAN	coiled-coil domain containing 28A	204											0				OV - Ovarian serous cystadenocarcinoma(155;0.000201)|GBM - Glioblastoma multiforme(68;0.000306)		ATGTTCCATTGAACAGATGGA	0.393		NaN											0	0	0	0.012213	0	34	42									
STX11	8676	broad.mit.edu	37	6	144508056	144508056	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:144508056G>A	uc003qks.3	+	2	484	c.292G>A	c.(292-294)GAG>AAG	p.E98K		NM_003764	NP_003755	O75558	STX11_HUMAN	syntaxin 11	98					cellular membrane fusion|intracellular protein transport|vesicle-mediated transport	Golgi apparatus|membrane	SNAP receptor activity			ovary(1)|central_nervous_system(1)	2				OV - Ovarian serous cystadenocarcinoma(155;2.17e-06)|GBM - Glioblastoma multiforme(68;0.0492)		GGCCCGGGGCGAGGTCATCCA	0.682		NaN							Familial_Hemophagocytic_Lymphohistiocytosis				0	0	0	0.013537	0	13	15									
PPP1R14C	81706	broad.mit.edu	37	6	150535916	150535916	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:150535916G>A	uc003qnt.2	+	2	484	c.343G>A	c.(343-345)GAT>AAT	p.D115N		NM_030949	NP_112211	Q8TAE6	PP14C_HUMAN	protein phosphatase 1, regulatory (inhibitor)	115					regulation of phosphorylation	cytoplasm|membrane					0		Ovarian(120;0.0284)	BRCA - Breast invasive adenocarcinoma(37;0.215)	OV - Ovarian serous cystadenocarcinoma(155;9.14e-12)		TGACATTGATGATCTTCTTGA	0.413		NaN											0	0	0	0.028581	0	15	53									
PARK2	5071	broad.mit.edu	37	6	162622255	162622255	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:162622255C>A	uc003qtx.3	-	4	576	c.442G>T	c.(442-444)GTG>TTG	p.V148L	PARK2_uc003qtv.3_RNA|PARK2_uc010kkd.2_5'UTR|PARK2_uc003qtw.3_Intron|PARK2_uc003qty.3_Missense_Mutation_p.V148L|PARK2_uc003qtz.3_Intron|PARK2_uc010kke.1_Missense_Mutation_p.V148L	NM_004562	NP_004553	O60260	PRKN2_HUMAN	parkin isoform 1	148					aggresome assembly|central nervous system development|mitochondrion degradation|negative regulation of actin filament bundle assembly|negative regulation of cell death|negative regulation of protein phosphorylation|negative regulation of release of cytochrome c from mitochondria|neuron death|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autoubiquitination|protein K48-linked ubiquitination|protein K63-linked ubiquitination|protein monoubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of autophagy|regulation of reactive oxygen species metabolic process	aggresome|cytosol|endoplasmic reticulum|Golgi apparatus|mitochondrion|nucleus|perinuclear region of cytoplasm	chaperone binding|PDZ domain binding|protein kinase binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding			upper_aerodigestive_tract(1)	1		all_cancers(1;8.13e-65)|all_epithelial(1;5.77e-64)|Colorectal(1;9.65e-15)|all_lung(1;1.66e-13)|Lung NSC(1;7.54e-11)|Melanoma(1;1.75e-09)|Breast(66;7.81e-05)|Ovarian(120;0.000981)|Prostate(117;0.0288)|Esophageal squamous(34;0.102)		UCEC - Uterine corpus endometrioid carcinoma (4;0.0663)|all cancers(1;1.9e-63)|Epithelial(1;1.5e-59)|Colorectal(1;2.16e-23)|OV - Ovarian serous cystadenocarcinoma(65;3.53e-20)|COAD - Colon adenocarcinoma(1;2.11e-15)|STAD - Stomach adenocarcinoma(1;4.64e-07)|BRCA - Breast invasive adenocarcinoma(81;1.49e-06)|READ - Rectum adenocarcinoma(1;2.95e-06)|GBM - Glioblastoma multiforme(2;7.23e-06)|Lung(1;0.00163)|KIRC - Kidney renal clear cell carcinoma(4;0.00371)|LUSC - Lung squamous cell carcinoma(1;0.00442)|Kidney(4;0.0046)		TTGCAATACACATAAAAGCTG	0.458		NaN											1	0	0.000442599	0.006214	0.000453596	9	38									
PURB	5814	broad.mit.edu	37	7	44924074	44924074	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:44924074C>T	uc003tme.2	-	1	887	c.874G>A	c.(874-876)GAG>AAG	p.E292K		NM_033224	NP_150093	Q96QR8	PURB_HUMAN	purine-rich element binding protein B	292					regulation of myeloid cell differentiation	DNA replication factor A complex	mRNA binding|single-stranded DNA binding|transcription factor binding				0						CCACGTCGCTCATAAAGCTTA	0.592		NaN											0	0	0	0.024334	0	25	62									
ZNF680	340252	broad.mit.edu	37	7	63982867	63982867	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:63982867G>C	uc003tta.2	-	4	438	c.265C>G	c.(265-267)CAT>GAT	p.H89D	ZNF680_uc010kzr.2_Missense_Mutation_p.H16D	NM_178558	NP_848653	Q8NEM1	ZN680_HUMAN	zinc finger protein 680 isoform 1	89					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(55;0.118)|all_lung(88;0.243)				TCAGTGAAATGAGAATATATA	0.289		NaN											0	0	0	0.006214	0	9	14									
TMEM120A	83862	broad.mit.edu	37	7	75617241	75617241	+	Missense_Mutation	SNP	T	T	G	rs35558484		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:75617241T>G	uc003ued.2	-	9	795	c.691A>C	c.(691-693)AGC>CGC	p.S231R	TMEM120A_uc003uee.2_Missense_Mutation_p.E169A|TMEM120A_uc003ueb.1_Missense_Mutation_p.S17R|TMEM120A_uc003uec.2_Missense_Mutation_p.S135R	NM_031925	NP_114131	Q9BXJ8	T120A_HUMAN	transmembrane protein 120A	231	Cytoplasmic (Potential).					integral to membrane					0						GGACACTCACTCTGGTACATG	0.612		NaN											0	0	0	0.021553	0	5	5									
PTPN12	5782	broad.mit.edu	37	7	77200497	77200497	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:77200497C>T	uc003ugh.2	+	2	293	c.202C>T	c.(202-204)CTG>TTG	p.L68L	PTPN12_uc011kgp.1_5'UTR|PTPN12_uc011kgq.1_5'UTR|PTPN12_uc010ldq.1_RNA|PTPN12_uc010ldr.1_RNA	NM_002835	NP_002826	Q05209	PTN12_HUMAN	protein tyrosine phosphatase, non-receptor type	68	Tyrosine-protein phosphatase.					soluble fraction	non-membrane spanning protein tyrosine phosphatase activity|SH3 domain binding			ovary(1)|breast(1)|pancreas(1)	3						CAAGGACATACTGCCATGTAA	0.328		NaN											0	0	0	0.021553	0	6	18									
OCM2	4951	broad.mit.edu	37	7	97619396	97619396	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:97619396G>A	uc003upc.2	-	1	21	c.21C>T	c.(19-21)CTC>CTT	p.L7L		NM_006188	NP_006179	P0CE71	OCM2_HUMAN	oncomodulin-like	7							calcium ion binding				0						CATCAGCACTGAGCACGTCCG	0.552		NaN											0	0	0	0.006214	0	8	23									
CNTNAP2	26047	broad.mit.edu	37	7	146805319	146805319	+	Missense_Mutation	SNP	G	G	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:146805319G>T	uc003weu.1	+	5	1147	c.631G>T	c.(631-633)GTC>TTC	p.V211F		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	211	Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			ACTGAAAGATGTCATTGCCTT	0.363		NaN								HNSCC(39;0.1)			1	0	2.35188e-11	0.006122	2.51987e-11	19	27									
CUL1	8454	broad.mit.edu	37	7	148481129	148481129	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:148481129G>A	uc010lpg.2	+	11	1784	c.1258G>A	c.(1258-1260)GAG>AAG	p.E420K	CUL1_uc003wey.2_Missense_Mutation_p.E420K|CUL1_uc003wez.2_Missense_Mutation_p.E310K|CUL1_uc003wfa.2_Missense_Mutation_p.E81K	NM_003592	NP_003583	Q13616	CUL1_HUMAN	cullin 1	420					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell cycle arrest|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein ubiquitination|S phase of mitotic cell cycle|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	cytosol|nucleoplasm|SCF ubiquitin ligase complex	ubiquitin protein ligase binding			lung(1)	1	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00291)			TAAATCCCCTGAGTTGCTGGC	0.418		NaN											0	0	0	0.006122	0	19	33									
ZNF425	155054	broad.mit.edu	37	7	148801438	148801438	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:148801438G>C	uc003wfj.2	-	4	1598	c.1525C>G	c.(1525-1527)CAG>GAG	p.Q509E		NM_001001661	NP_001001661	Q6IV72	ZN425_HUMAN	zinc finger protein 425	509	C2H2-type 11.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CGCGACTGCTGAGAAAAGGTC	0.637		NaN											0	0	0	0.004482	0	8	12									
ZNF425	155054	broad.mit.edu	37	7	148802519	148802519	+	Silent	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:148802519G>C	uc003wfj.2	-	4	517	c.444C>G	c.(442-444)CTC>CTG	p.L148L		NM_001001661	NP_001001661	Q6IV72	ZN425_HUMAN	zinc finger protein 425	148					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|zinc ion binding			breast(2)|ovary(1)	3	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00463)			CTGTTTCTCGGAGACTTGGAG	0.458		NaN											0	0	0	0.016522	0	24	49									
ZNF777	27153	broad.mit.edu	37	7	149152911	149152911	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:149152911G>A	uc003wfv.2	-	2	366	c.203C>T	c.(202-204)TCT>TTT	p.S68F		NM_015694	NP_056509	Q9ULD5	ZN777_HUMAN	zinc finger protein 777	68					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1	Melanoma(164;0.165)		OV - Ovarian serous cystadenocarcinoma(82;0.00358)			CATCCGGCCAGAAGTCTCTTG	0.577		NaN											0	0	0	0.027356	0	28	64									
GIMAP7	168537	broad.mit.edu	37	7	150217669	150217669	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:150217669G>C	uc003whk.2	+	2	737	c.607G>C	c.(607-609)GAT>CAT	p.D203H		NM_153236	NP_694968	Q8NHV1	GIMA7_HUMAN	GTPase, IMAP family member 7	203							GTP binding			pancreas(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(82;0.0218)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)		TTACTTTTCTGATGACATATA	0.418		NaN											0	0	0	0.006122	0	19	35									
WDR60	55112	broad.mit.edu	37	7	158663923	158663923	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr7:158663923G>A	uc003woe.3	+	3	318	c.160G>A	c.(160-162)GAG>AAG	p.E54K		NM_018051	NP_060521	Q8WVS4	WDR60_HUMAN	WD repeat domain 60	54										ovary(2)|breast(1)|central_nervous_system(1)	4	Ovarian(565;0.152)	all_cancers(7;1.25e-09)|all_epithelial(9;0.000894)|all_hematologic(28;0.00603)	OV - Ovarian serous cystadenocarcinoma(82;0.00174)	UCEC - Uterine corpus endometrioid carcinoma (81;0.19)|STAD - Stomach adenocarcinoma(7;0.18)		TGAACATAAGGAGCCGAGGTG	0.507		NaN											0	0	0	0.004482	0	8	12									
MTUS1	57509	broad.mit.edu	37	8	17507472	17507472	+	Splice_Site	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr8:17507472C>T	uc003wxv.2	-	13	3859	c.3385_splice	c.e13-1	p.K1129_splice	MTUS1_uc003wxt.2_Splice_Site_p.K376_splice|MTUS1_uc011kyg.1_Splice_Site_p.K274_splice|MTUS1_uc010lsy.2_Splice_Site|MTUS1_uc003wxw.2_Splice_Site_p.K1075_splice|MTUS1_uc003wxs.2_Splice_Site_p.K295_splice	NM_001001924	NP_001001924	Q9ULD2	MTUS1_HUMAN	mitochondrial tumor suppressor 1 isoform 1							Golgi apparatus|microtubule|microtubule organizing center|mitochondrion|nucleus|plasma membrane|spindle				ovary(1)|skin(1)	2				Colorectal(111;0.0778)		GAGGATTTTTCTGGAAAGGAC	0.368		NaN											0	0	0	0.010818	0	33	15									
MYST3	7994	broad.mit.edu	37	8	41790517	41790517	+	Missense_Mutation	SNP	C	C	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr8:41790517C>A	uc010lxb.2	-	18	5765	c.5221G>T	c.(5221-5223)GCC>TCC	p.A1741S	MYST3_uc010lxc.2_Missense_Mutation_p.A1741S|MYST3_uc003xon.3_Missense_Mutation_p.A1741S	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	1741					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			TAGCTGCCGGCACCAAAATCC	0.498		NaN											1	0	8.88839e-20	0.010818	9.61695e-20	34	75									
STK3	6788	broad.mit.edu	37	8	99468130	99468130	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr8:99468130C>T	uc003yip.2	-	11	1557	c.1416G>A	c.(1414-1416)GCG>GCA	p.A472A	STK3_uc003yio.2_Silent_p.A500A	NM_006281	NP_006272	Q13188	STK3_HUMAN	serine/threonine kinase 3	472	SARAH.|Potential.				apoptosis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of apoptosis	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein dimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity			lung(3)|ovary(1)	4	Breast(36;2.4e-06)	Breast(495;0.106)	OV - Ovarian serous cystadenocarcinoma(57;0.0382)	KIRC - Kidney renal clear cell carcinoma(542;9.44e-06)		GCTGTCTTTTCGCAGTGTATC	0.408		NaN											0	0	0	0.006214	0	9	11									
ZNF706	51123	broad.mit.edu	37	8	102213947	102213947	+	Missense_Mutation	SNP	A	A	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr8:102213947A>T	uc003yka.2	-	3	438	c.23T>A	c.(22-24)ATT>AAT	p.I8N	ZNF706_uc003ykb.2_Missense_Mutation_p.I8N	NM_001042510	NP_001035975	Q9Y5V0	ZN706_HUMAN	HSPC038 protein	8						intracellular	zinc ion binding			ovary(2)	2	all_cancers(14;3.3e-07)|all_epithelial(15;3.47e-09)|Lung NSC(17;3.44e-05)|all_lung(17;0.000117)		Epithelial(11;8.57e-11)|all cancers(13;1.43e-08)|OV - Ovarian serous cystadenocarcinoma(57;1.43e-05)			CTGAGACTGAATTTTCTGCTG	0.393		NaN											0	0	0	0.020292	0	12	25									
ZNF706	51123	broad.mit.edu	37	8	102213962	102213962	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr8:102213962C>G	uc003yka.2	-	3	423	c.8G>C	c.(7-9)CGT>CCT	p.R3P	ZNF706_uc003ykb.2_Missense_Mutation_p.R3P	NM_001042510	NP_001035975	Q9Y5V0	ZN706_HUMAN	HSPC038 protein	3						intracellular	zinc ion binding	p.R3P(2)		ovary(2)	2	all_cancers(14;3.3e-07)|all_epithelial(15;3.47e-09)|Lung NSC(17;3.44e-05)|all_lung(17;0.000117)		Epithelial(11;8.57e-11)|all cancers(13;1.43e-08)|OV - Ovarian serous cystadenocarcinoma(57;1.43e-05)			CTGCTGTCCACGAGCCATATC	0.398		NaN											0	0	0	0.028581	0	8	19									
ATAD2	29028	broad.mit.edu	37	8	124371477	124371477	+	Nonsense_Mutation	SNP	T	T	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr8:124371477T>A	uc003yqh.3	-	11	1474	c.1366A>T	c.(1366-1368)AAA>TAA	p.K456*	ATAD2_uc011lii.1_Nonsense_Mutation_p.K247*|ATAD2_uc003yqi.3_RNA|ATAD2_uc003yqj.2_Nonsense_Mutation_p.K456*	NM_014109	NP_054828	Q6PL18	ATAD2_HUMAN	ATPase family, AAA domain containing 2	456					regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrion|nucleus	ATP binding|ATPase activity			ovary(2)	2	Lung NSC(37;1.25e-09)|Ovarian(258;0.00838)		STAD - Stomach adenocarcinoma(47;0.00288)			GGTTGAATTTTAAATTTTTCA	0.323		NaN											0	0	0	0.024334	0	25	41									
PLEC	5339	broad.mit.edu	37	8	144993273	144993273	+	Silent	SNP	G	G	A	rs34365303		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr8:144993273G>A	uc003zaf.1	-	32	11297	c.11127C>T	c.(11125-11127)ATC>ATT	p.I3709I	PLEC_uc003zab.1_Silent_p.I3572I|PLEC_uc003zac.1_Silent_p.I3576I|PLEC_uc003zad.2_Silent_p.I3572I|PLEC_uc003zae.1_Silent_p.I3540I|PLEC_uc003zag.1_Silent_p.I3550I|PLEC_uc003zah.2_Silent_p.I3558I|PLEC_uc003zaj.2_Silent_p.I3599I	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	3709	Globular 2.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CGGGAATGTCGATCTGTGTCT	0.632		NaN											0	0	0	0.004482	0	7	150									
FBXO10	26267	broad.mit.edu	37	9	37537289	37537289	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:37537289C>G	uc004aab.2	-	3	1286	c.1237G>C	c.(1237-1239)GAG>CAG	p.E413Q	FBXO10_uc004aac.2_Missense_Mutation_p.E429Q|FBXO10_uc004aad.2_Intron	NM_012166	NP_036298	Q9UK96	FBX10_HUMAN	F-box protein 10	413						ubiquitin ligase complex	ubiquitin-protein ligase activity			lung(5)	5				GBM - Glioblastoma multiforme(29;0.0107)		TTCTGCAGCTCCTGCTGCAGT	0.627		NaN											0	0	0	0.006214	0	10	1									
NTRK2	4915	broad.mit.edu	37	9	87482169	87482169	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:87482169G>A	uc004aoa.1	+	15	2346	c.1408G>A	c.(1408-1410)GTT>ATT	p.V470I	NTRK2_uc004any.1_Missense_Mutation_p.V470I|NTRK2_uc004anz.1_Missense_Mutation_p.V486I|NTRK2_uc011lsz.1_Missense_Mutation_p.V486I|NTRK2_uc011lta.1_Missense_Mutation_p.V470I|NTRK2_uc004aoc.2_Missense_Mutation_p.V21I	NM_001018064	NP_001018074	Q16620	NTRK2_HUMAN	neurotrophic tyrosine kinase, receptor, type 2	470	Cytoplasmic (Potential).				activation of adenylate cyclase activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development	integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein tyrosine kinase activity			lung(11)|central_nervous_system(1)|breast(1)|skin(1)|ovary(1)|liver(1)	16						CCCAGCCTCCGTTATCAGCAA	0.343		NaN								TSP Lung(25;0.17)			0	0	0	0.016522	0	24	43									
ZCCHC6	79670	broad.mit.edu	37	9	88938224	88938224	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:88938224C>G	uc004aoq.2	-	13	2656	c.2441G>C	c.(2440-2442)GGA>GCA	p.G814A	ZCCHC6_uc011ltf.1_RNA|ZCCHC6_uc004aor.2_RNA|ZCCHC6_uc004aos.2_RNA|ZCCHC6_uc004aot.2_Missense_Mutation_p.G691A|ZCCHC6_uc004aou.2_Missense_Mutation_p.G814A	NM_024617	NP_078893	Q5VYS8	TUT7_HUMAN	zinc finger, CCHC domain containing 6	814					RNA 3'-end processing		nucleic acid binding|RNA uridylyltransferase activity|zinc ion binding			ovary(2)	2						TGTACTTTCTCCATCAAGATC	0.423		NaN											0	0	0	0.007291	0	28	62									
FAM75C1	441452	broad.mit.edu	37	9	90537046	90537046	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:90537046C>G	uc010mqi.2	+	4	2253	c.2224C>G	c.(2224-2226)CCT>GCT	p.P742A	FAM75C1_uc004apq.3_Missense_Mutation_p.P725A	NM_001145124	NP_001138596			family with sequence similarity 75, member C1												0						GGCCTCCTCACCTGCATGTAA	0.577		NaN											0	0	0	0.00499	0	16	39									
NR4A3	8013	broad.mit.edu	37	9	102590462	102590462	+	Silent	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:102590462G>A	uc004baf.1	+	3	867	c.138G>A	c.(136-138)GAG>GAA	p.E46E	NR4A3_uc004bae.2_Silent_p.E46E|NR4A3_uc004bag.1_Silent_p.E46E|NR4A3_uc004bai.2_Silent_p.E57E	NM_006981	NP_008912	Q92570	NR4A3_HUMAN	nuclear receptor subfamily 4, group A, member 3	46					regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor		steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding		EWSR1/NR4A3(140)|TAF15/NR4A3(33)	bone(173)	173		Acute lymphoblastic leukemia(62;0.0559)|all_hematologic(171;0.189)				GCAGCACTGAGATCACGGCTA	0.562		NaN	T	EWSR1	extraskeletal myxoid chondrosarcoma								0	0	0	0.012319	0	19	39									
FKBP15	23307	broad.mit.edu	37	9	115931520	115931520	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:115931520G>A	uc004bgs.2	-	26	3587	c.3469C>T	c.(3469-3471)CAT>TAT	p.H1157Y	FKBP15_uc004bgr.2_Missense_Mutation_p.H594Y|FKBP15_uc011lxc.1_Missense_Mutation_p.H738Y|FKBP15_uc011lxd.1_Missense_Mutation_p.H1089Y	NM_015258	NP_056073	Q5T1M5	FKB15_HUMAN	FK506 binding protein 15, 133kDa	1157					endocytosis|protein folding	axon|early endosome	actin binding			ovary(3)	3						CGCTGGGAATGATGGCTGGGT	0.542		NaN											0	0	0	0.013537	0	13	15									
TRIM32	22954	broad.mit.edu	37	9	119461874	119461874	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:119461874G>A	uc004bjx.2	+	2	2011	c.1853G>A	c.(1852-1854)TGT>TAT	p.C618Y	ASTN2_uc004bjr.1_Intron|ASTN2_uc004bjs.1_Intron|ASTN2_uc004bjt.1_Intron|TRIM32_uc004bjw.2_Missense_Mutation_p.C618Y	NM_001099679	NP_001093149	Q13049	TRI32_HUMAN	tripartite motif-containing 32	618	NHL 5.				fat cell differentiation|innate immune response|negative regulation of apoptosis|negative regulation of fibroblast proliferation|positive regulation of cell cycle|positive regulation of cell growth|positive regulation of cell migration|positive regulation of neurogenesis|positive regulation of neuron differentiation|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein catabolic process|positive regulation of proteolysis|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to tumor necrosis factor|response to UV	nucleus	myosin binding|protein self-association|RNA binding|Tat protein binding|transcription coactivator activity|translation initiation factor binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(2)|kidney(1)	3						GGACTTACCTGTCCGGTGGGC	0.507		NaN							Bardet-Biedl_syndrome				0	0	0	0.006122	0	18	38									
WDR34	89891	broad.mit.edu	37	9	131396647	131396647	+	Silent	SNP	G	G	A	rs146817584		TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:131396647G>A	uc004bvq.1	-	8	1354	c.1230C>T	c.(1228-1230)AGC>AGT	p.S410S	WDR34_uc004bvs.1_Silent_p.S401S|WDR34_uc004bvr.1_Silent_p.S382S	NM_052844	NP_443076	Q96EX3	WDR34_HUMAN	WD repeat domain 34	410	WD 3.					cytoplasm				central_nervous_system(2)|skin(1)	3						CAGTCCCAGCGCTCAGGAAGA	0.627		NaN											0	0	0	0.020292	0	15	34									
NUP188	23511	broad.mit.edu	37	9	131768567	131768567	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:131768567C>G	uc004bws.1	+	43	5015	c.4993C>G	c.(4993-4995)CAG>GAG	p.Q1665E		NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	nucleoporin 188kDa	1665					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)|kidney(1)|breast(1)	7						GCTCATCTCTCAGGCGATGCG	0.572		NaN									OREG0019528	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.013726	0	35	81									
GRIN1	2902	broad.mit.edu	37	9	140057342	140057342	+	Missense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:140057342G>C	uc004clk.2	+	15	2388	c.2058G>C	c.(2056-2058)CAG>CAC	p.Q686H	GRIN1_uc004cli.1_Missense_Mutation_p.Q361H|GRIN1_uc004clj.1_Missense_Mutation_p.Q683H|GRIN1_uc004cll.2_Missense_Mutation_p.Q686H|GRIN1_uc004clm.2_Missense_Mutation_p.Q686H|GRIN1_uc004cln.2_Missense_Mutation_p.Q704H|GRIN1_uc004clo.2_Missense_Mutation_p.Q704H	NM_007327	NP_015566	Q05586	NMDZ1_HUMAN	NMDA receptor 1 isoform NR1-3 precursor	686	Extracellular (Potential).				ionotropic glutamate receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|regulation of excitatory postsynaptic membrane potential|response to ethanol|visual learning	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane|synaptic vesicle|synaptosome	calcium ion binding|calmodulin binding|extracellular-glutamate-gated ion channel activity|glutamate binding|glycine binding			skin(1)	1	all_cancers(76;0.0926)		STAD - Stomach adenocarcinoma(284;0.0878)	OV - Ovarian serous cystadenocarcinoma(145;6.87e-05)|Epithelial(140;0.00095)	L-Glutamic Acid(DB00142)|Orphenadrine(DB01173)	CGGTGAAGCAGAGCTCCGTGG	0.637		NaN											0	0	0	0.004672	0	3	5									
EHMT1	79813	broad.mit.edu	37	9	140695358	140695358	+	Silent	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:140695358C>T	uc011mfc.1	+	18	2671	c.2634C>T	c.(2632-2634)ATC>ATT	p.I878I		NM_024757	NP_079033	Q9H9B1	EHMT1_HUMAN	euchromatic histone-lysine N-methyltransferase 1	878	ANK 5.				DNA methylation|embryo development|peptidyl-lysine dimethylation|peptidyl-lysine monomethylation	chromosome|nucleus	histone methyltransferase activity (H3-K27 specific)|histone methyltransferase activity (H3-K9 specific)|p53 binding|zinc ion binding			breast(2)|pancreas(1)	3	all_cancers(76;0.164)			OV - Ovarian serous cystadenocarcinoma(145;0.000183)|Epithelial(140;0.000728)		CACCCATGATCTGGGCCACAG	0.587		NaN											0	0	0	0.009096	0	4	21									
MXRA5	25878	broad.mit.edu	37	X	3238723	3238723	+	Nonsense_Mutation	SNP	G	G	C			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chrX:3238723G>C	uc004crg.3	-	5	5160	c.5003C>G	c.(5002-5004)TCA>TGA	p.S1668*		NM_015419	NP_056234	Q9NR99	MXRA5_HUMAN	adlican precursor	1668						extracellular region				ovary(5)|lung(1)|central_nervous_system(1)|skin(1)	8		all_lung(23;0.00031)|Lung NSC(23;0.000946)				TGTTGTACTTGATAATCTTGG	0.438		NaN											0	0	0	0.01441	0	150	35									
UBA1	7317	broad.mit.edu	37	X	47062396	47062396	+	Missense_Mutation	SNP	G	G	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chrX:47062396G>A	uc004dhj.3	+	12	1439	c.1288G>A	c.(1288-1290)GAG>AAG	p.E430K	UBA1_uc004dhk.3_Missense_Mutation_p.E430K|INE1_uc004dhl.2_5'Flank	NM_153280	NP_695012	P22314	UBA1_HUMAN	ubiquitin-activating enzyme E1	430	2 approximate repeats.				cell death|protein modification process		ATP binding|ligase activity|protein binding|small protein activating enzyme activity			ovary(1)	1						TGATGCCCTTGAGTGTCTCCC	0.582		NaN											0	0	0	0.027894	0	39	5									
KCND1	3750	broad.mit.edu	37	X	48825780	48825780	+	Missense_Mutation	SNP	A	A	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chrX:48825780A>G	uc004dlx.1	-	1	2472	c.899T>C	c.(898-900)TTT>TCT	p.F300S	KCND1_uc004dlw.1_5'Flank	NM_004979	NP_004970	Q9NSA2	KCND1_HUMAN	potassium voltage-gated channel, Shal-related	300	Helical; Voltage-sensor; Name=Segment S4; (Potential).					voltage-gated potassium channel complex	metal ion binding|voltage-gated potassium channel activity			ovary(2)|lung(1)	3						GAAGATGCGAAACACCCGGAA	0.552		NaN											0	0	0	0.008291	0	10	15									
TRO	7216	broad.mit.edu	37	X	54955643	54955643	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chrX:54955643C>G	uc004dtq.2	+	12	2593	c.2486C>G	c.(2485-2487)TCT>TGT	p.S829C	TRO_uc004dts.2_Intron|TRO_uc004dtr.2_Intron|TRO_uc004dtt.2_Intron|TRO_uc004dtu.2_Intron|TRO_uc004dtv.2_Intron|TRO_uc011mok.1_Missense_Mutation_p.S360C|TRO_uc004dtw.2_Missense_Mutation_p.S432C|TRO_uc004dtx.2_Missense_Mutation_p.S212C	NM_001039705	NP_001034794	Q12816	TROP_HUMAN	trophinin isoform 5	829	6; approximate.|62 X 10 AA approximate tandem repeats.				embryo implantation|homophilic cell adhesion	integral to plasma membrane				ovary(1)	1						GGAGTCAGCTCTAGTTTTAGT	0.547		NaN											0	0	0	0.023175	0	41	6									
RPS4X	6191	broad.mit.edu	37	X	71493144	71493144	+	Missense_Mutation	SNP	C	C	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chrX:71493144C>T	uc004ear.2	-	6	724	c.628G>A	c.(628-630)GTG>ATG	p.V210M		NM_001007	NP_000998	P62701	RS4X_HUMAN	ribosomal protein S4, X-linked X isoform	210					endocrine pancreas development|positive regulation of cell proliferation|positive regulation of translation|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit|polysome	rRNA binding|structural constituent of ribosome				0	Renal(35;0.156)					GCATCTTTCACGTGAACCACG	0.463		NaN											0	0	0	0.015359	0	34	3									
KIAA1210	57481	broad.mit.edu	37	X	118228014	118228014	+	Missense_Mutation	SNP	C	C	G			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chrX:118228014C>G	uc004era.3	-	9	1312	c.1312G>C	c.(1312-1314)GAG>CAG	p.E438Q		NM_020721	NP_065772	Q9ULL0	K1210_HUMAN	hypothetical protein LOC57481	438										ovary(4)|skin(1)	5						AGGGATCCCTCTAAAATACCC	0.483		NaN											0	0	0	0.008361	0	32	5									
ELF3	1999	broad.mit.edu	37	1	201980282	201980282	+	Frame_Shift_Del	DEL	G	G	-			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08			G	-	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:201980282delG	uc001gxg.3	+	1	3210	c.18delG	c.(16-18)GAGfs	p.E6fs	ELF3_uc001gxi.3_Frame_Shift_Del_p.E6fs|ELF3_uc001gxh.3_Frame_Shift_Del_p.E6fs	NM_004433	NP_004424	P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription	6					epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0						CAACCTGTGAGATTAGCAACA	0.567		NaN											NaN	NaN	NaN	NaN	NaN	23	22	---	---							
OR2T3	343173	broad.mit.edu	37	1	248637607	248637607	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr1:248637607delA	uc001iel.1	+	1	956	c.956delA	c.(955-957)TAGfs	p.*319fs		NM_001005495	NP_001005495	Q8NH03	OR2T3_HUMAN	olfactory receptor, family 2, subfamily T,	319					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CAAGAAAAGTAGTAAAGGGCA	0.502		NaN											NaN	NaN	NaN	NaN	NaN	38	185	---	---							
JUP	3728	broad.mit.edu	37	17	39680110	39680111	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr17:39680110_39680111insA	uc010wfs.1	-	9	1584_1585	c.1576_1577insT	c.(1576-1578)TACfs	p.Y526fs	KRT15_uc002hxb.1_5'Flank|uc002hxc.1_5'Flank|KRT19_uc002hxd.3_Frame_Shift_Ins_p.Y363fs	NM_021991	NP_068831	P14923	PLAK_HUMAN	junction plakoglobin	Error:Variant_position_missing_in_P14923_after_alignment					adherens junction organization|atrioventricular valve morphogenesis|cell migration|cell morphogenesis|cellular response to indole-3-methanol|cytoskeletal anchoring at plasma membrane|detection of mechanical stimulus|ectoderm development|endothelial cell-cell adhesion|gastrulation|morphogenesis of embryonic epithelium|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of Wnt receptor signaling pathway involved in heart development|nervous system development|oocyte development|positive regulation of protein import into nucleus|positive regulation of sequence-specific DNA binding transcription factor activity|skin development	actin cytoskeleton|Axin-APC-beta-catenin-GSK3B complex|basolateral plasma membrane|catenin complex|desmosome|fascia adherens|gamma-catenin-TCF7L2 complex|internal side of plasma membrane|nucleus|protein-DNA complex|Z disc|zonula adherens	alpha-catenin binding|cadherin binding|protein homodimerization activity|protein kinase binding|protein phosphatase binding|RPTP-like protein binding|specific RNA polymerase II transcription factor activity|transcription coactivator activity			ovary(2)|lung(2)|breast(1)	5		Breast(137;0.000162)	BRCA - Breast invasive adenocarcinoma(4;0.233)	BRCA - Breast invasive adenocarcinoma(366;0.15)		GAGCCGCTGGTACTCCTGATTC	0.589		NaN											NaN	NaN	NaN	NaN	NaN	13	61	---	---							
FAT1	2195	broad.mit.edu	37	4	187539870	187539870	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr4:187539870delC	uc003izf.2	-	10	8058	c.7870delG	c.(7870-7872)GATfs	p.D2624fs		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	2624	Extracellular (Potential).|Cadherin 24.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GAGCCCTCATCGGCATCACTT	0.443		NaN								HNSCC(5;0.00058)			NaN	NaN	NaN	NaN	NaN	11	29	---	---							
FOXQ1	94234	broad.mit.edu	37	6	1313536	1313537	+	Frame_Shift_Ins	INS	-	-	A			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08			-	A	-	-		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:1313536_1313537insA	uc003mtl.3	+	1	862_863	c.597_598insA	c.(595-600)AACAGCfs	p.N199fs		NM_033260	NP_150285	Q9C009	FOXQ1_HUMAN	forkhead box Q1	199_200	Fork-head.				DNA fragmentation involved in apoptotic nuclear change|embryo development|hair follicle morphogenesis|pattern specification process|positive regulation of caspase activity|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	caspase regulator activity|DNA bending activity|double-stranded DNA binding|estrogen receptor binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|ubiquitin conjugating enzyme binding				0	Ovarian(93;0.0733)	Breast(5;0.052)|all_lung(73;0.0713)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.0954)|BRCA - Breast invasive adenocarcinoma(62;0.18)		TCAACCCCAACAGCGAGTACAC	0.515		NaN											NaN	NaN	NaN	NaN	NaN	23	7	---	---							
MLLT4	4301	broad.mit.edu	37	6	168317781	168317782	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr6:168317781_168317782insT	uc003qwd.2	+	19	2696_2697	c.2554_2555insT	c.(2554-2556)CTTfs	p.L852fs	MLLT4_uc003qwb.1_Frame_Shift_Ins_p.L837fs|MLLT4_uc003qwc.1_Frame_Shift_Ins_p.L853fs|MLLT4_uc003qwg.1_Frame_Shift_Ins_p.L162fs	NM_001040001	NP_001035090	P55196	AFAD_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	853	Dilute.				adherens junction organization|cell adhesion|cell junction assembly|cell-cell signaling|signal transduction	adherens junction|cell-cell junction|cytosol|nucleus	protein C-terminus binding			ovary(2)|lung(1)|kidney(1)|central_nervous_system(1)	5		Breast(66;1.07e-05)|Ovarian(120;0.024)		Epithelial(4;2.38e-32)|OV - Ovarian serous cystadenocarcinoma(33;9.99e-23)|BRCA - Breast invasive adenocarcinoma(4;1.2e-11)|GBM - Glioblastoma multiforme(31;0.00117)		AACGACTTTGCTTACCATGGAT	0.277		NaN	T	MLL	AL								NaN	NaN	NaN	NaN	NaN	15	46	---	---							
GPR107	57720	broad.mit.edu	37	9	132869776	132869779	+	Frame_Shift_Del	DEL	TCAA	TCAA	-			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:132869776_132869779delTCAA	uc004bze.2	+	14	1491_1494	c.1264_1267delTCAA	c.(1264-1269)TCAATCfs	p.S422fs	GPR107_uc004bzb.2_Frame_Shift_Del_p.S233fs|GPR107_uc004bzc.3_RNA|GPR107_uc011mbx.1_Frame_Shift_Del_p.S422fs|GPR107_uc004bzd.2_Frame_Shift_Del_p.S422fs|uc004bzf.2_5'Flank	NM_001136557	NP_001130029	Q5VW38	GP107_HUMAN	G protein-coupled receptor 107 isoform 1	422_423	Helical; Name=5; (Potential).					integral to membrane				upper_aerodigestive_tract(1)	1		Ovarian(14;0.000531)				TATTTTTAGGTCAATCAGACATTT	0.407		NaN									OREG0019542	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	NaN	NaN	NaN	NaN	NaN	15	11	---	---							
LCN15	389812	broad.mit.edu	37	9	139658915	139658915	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CU-A3YL-01A-11D-A22Z-08	TCGA-CU-A3YL-10A-01D-A22Z-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2a512bd0-059f-4dcc-846e-fa6dc043c5d1	1dc354e4-2157-4b5e-afb3-5df0822649c7	g.chr9:139658915delA	uc004cjd.2	-	1	51	c.26delT	c.(25-27)ATCfs	p.I9fs		NM_203347	NP_976222	Q6UWW0	LCN15_HUMAN	lipocalin 15 precursor	9					lipid metabolic process	extracellular region	binding|transporter activity				0						CAGGGTCAGGATTGCGCCGAG	0.642		NaN											NaN	NaN	NaN	NaN	NaN	7	7	---	---							
