Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
TAS1R3	83756	broad.mit.edu	37	1	1267276	1267276	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:1267276C>T	uc010nyk.1	+	2	450	c.450C>T	c.(448-450)GCC>GCT	p.A150A		NM_152228	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3 precursor	150	Extracellular (Potential).				detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	CAGAGCTCGCCATGGTCACCG	0.677		NaN											0	0	0	0.012319	0	17	61									
GNB1	2782	broad.mit.edu	37	1	1749278	1749278	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:1749278G>T	uc001aif.2	-	4	426	c.94C>A	c.(94-96)CAG>AAG	p.Q32K	GNB1_uc009vky.2_Intron	NM_002074	NP_002065	P62873	GBB1_HUMAN	guanine nucleotide-binding protein, beta-1	32					cellular response to glucagon stimulus|energy reserve metabolic process|muscarinic acetylcholine receptor signaling pathway|platelet activation|Ras protein signal transduction|synaptic transmission	heterotrimeric G-protein complex	GTPase activity|GTPase binding|signal transducer activity				0	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;5.62e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;1.14e-35)|OV - Ovarian serous cystadenocarcinoma(86;7.31e-23)|GBM - Glioblastoma multiforme(42;3.1e-07)|COAD - Colon adenocarcinoma(227;0.000323)|Colorectal(212;0.000374)|Kidney(185;0.00392)|BRCA - Breast invasive adenocarcinoma(365;0.00573)|STAD - Stomach adenocarcinoma(132;0.0072)|KIRC - Kidney renal clear cell carcinoma(229;0.0482)|Lung(427;0.236)		GCTCTTACCTGAGAGAGAGTT	0.547		NaN											1	0	0.00909568	0.009096	0.00928131	3	58									
ICMT	23463	broad.mit.edu	37	1	6293642	6293642	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:6293642G>A	uc001amk.2	-	3	419	c.346C>T	c.(346-348)CCC>TCC	p.P116S	ICMT_uc001aml.2_Missense_Mutation_p.P20S	NM_012405	NP_036537	O60725	ICMT_HUMAN	isoprenylcysteine carboxyl methyltransferase	116					protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane|membrane fraction	protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity				0	Ovarian(185;0.0634)	all_cancers(23;5.85e-39)|all_epithelial(116;2.4e-22)|all_lung(118;2.65e-08)|Lung NSC(185;6.45e-07)|all_neural(13;3.18e-06)|all_hematologic(16;8.99e-06)|Acute lymphoblastic leukemia(12;0.000365)|Breast(487;0.000688)|Renal(390;0.0007)|Colorectal(325;0.00104)|Glioma(11;0.00203)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0392)|Medulloblastoma(700;0.211)		Epithelial(90;5.52e-38)|GBM - Glioblastoma multiforme(13;6.51e-32)|OV - Ovarian serous cystadenocarcinoma(86;3.03e-19)|Colorectal(212;7.08e-08)|COAD - Colon adenocarcinoma(227;8.35e-06)|Kidney(185;4.89e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.000911)|BRCA - Breast invasive adenocarcinoma(365;0.00109)|STAD - Stomach adenocarcinoma(132;0.00313)|READ - Rectum adenocarcinoma(331;0.0642)|Lung(427;0.182)		AGACTTTTGGGATTATTGACT	0.398		NaN											0	0	0	0.001984	0	6	74									
SPEN	23013	broad.mit.edu	37	1	16262633	16262633	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:16262633G>T	uc001axk.1	+	11	10102	c.9898G>T	c.(9898-9900)GGG>TGG	p.G3300W	SPEN_uc010obp.1_Missense_Mutation_p.G3259W	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	3300	Pro-rich.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		GCACTCCAGCGGGGAGCTGTT	0.627		NaN											1	0	5.3912e-06	0.006122	5.72517e-06	17	162									
UBR4	23352	broad.mit.edu	37	1	19454159	19454159	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:19454159G>A	uc001bbi.2	-	63	9190	c.9186C>T	c.(9184-9186)TTC>TTT	p.F3062F	UBR4_uc001bbk.1_Silent_p.F709F	NM_020765	NP_065816	Q5T4S7	UBR4_HUMAN	retinoblastoma-associated factor 600	3062					interspecies interaction between organisms	cytoplasm|cytoskeleton|integral to membrane|nucleus	calmodulin binding|ubiquitin-protein ligase activity|zinc ion binding			kidney(10)|ovary(7)|breast(4)|pancreas(2)|skin(2)	25		Colorectal(325;3.46e-05)|Renal(390;0.000147)|all_lung(284;0.000328)|Lung NSC(340;0.000406)|Breast(348;0.000814)|Ovarian(437;0.00774)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00674)|BRCA - Breast invasive adenocarcinoma(304;5.43e-05)|Kidney(64;0.000337)|KIRC - Kidney renal clear cell carcinoma(64;0.00426)|STAD - Stomach adenocarcinoma(196;0.00715)|READ - Rectum adenocarcinoma(331;0.0816)		TGCGGGACATGAAGACACTCA	0.488		NaN											0	0	0	0.008291	0	10	102									
EIF4G3	8672	broad.mit.edu	37	1	21154159	21154159	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:21154159C>G	uc001bec.2	-	27	4308	c.4052G>C	c.(4051-4053)AGA>ACA	p.R1351T	EIF4G3_uc010odi.1_Missense_Mutation_p.R955T|EIF4G3_uc010odj.1_Missense_Mutation_p.R1350T|EIF4G3_uc009vpz.2_Missense_Mutation_p.R1071T|EIF4G3_uc001bed.2_Missense_Mutation_p.R1351T|EIF4G3_uc001bef.2_Missense_Mutation_p.R1387T|EIF4G3_uc001bee.2_Missense_Mutation_p.R1357T	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	1351					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		GACCCCAGCTCTTCCAACAGG	0.388		NaN											0	0	0	0.009096	0	3	55									
MYOM3	127294	broad.mit.edu	37	1	24418668	24418668	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:24418668C>T	uc001bin.3	-	11	1391	c.1228G>A	c.(1228-1230)GAG>AAG	p.E410K	MYOM3_uc001bim.3_Missense_Mutation_p.E67K|MYOM3_uc001bio.2_Missense_Mutation_p.E410K|MYOM3_uc001bip.1_Missense_Mutation_p.E67K	NM_152372	NP_689585	Q5VTT5	MYOM3_HUMAN	myomesin family, member 3	410	Fibronectin type-III 1.									skin(2)|ovary(1)	3		Colorectal(325;3.55e-05)|Renal(390;0.000703)|Lung NSC(340;0.001)|all_lung(284;0.0014)|Ovarian(437;0.00351)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;5.31e-24)|Colorectal(126;7.52e-08)|COAD - Colon adenocarcinoma(152;4.01e-06)|GBM - Glioblastoma multiforme(114;4.36e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00108)|KIRC - Kidney renal clear cell carcinoma(1967;0.00404)|STAD - Stomach adenocarcinoma(196;0.00966)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.153)		ACTCACCGCTCAATGGTGTAG	0.602		NaN											0	0	0	0.00245	0	10	75									
PTPRF	5792	broad.mit.edu	37	1	44072610	44072610	+	Silent	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:44072610C>G	uc001cjr.2	+	21	4168	c.3828C>G	c.(3826-3828)CTC>CTG	p.L1276L	PTPRF_uc001cjs.2_Silent_p.L1267L|PTPRF_uc001cju.2_Silent_p.L654L|PTPRF_uc009vwt.2_Silent_p.L836L|PTPRF_uc001cjv.2_Silent_p.L736L|PTPRF_uc001cjw.2_Silent_p.L502L	NM_002840	NP_002831	P10586	PTPRF_HUMAN	protein tyrosine phosphatase, receptor type, F	1276	Helical; (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			ovary(4)|skin(3)|lung(1)|kidney(1)|central_nervous_system(1)	10	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0333)				TCATCATCCTCATTGTCATCG	0.622		NaN											0	0	0	0.010729	0	10	128									
IPO13	9670	broad.mit.edu	37	1	44426671	44426671	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:44426671G>C	uc001ckx.2	+	13	3028	c.2233G>C	c.(2233-2235)GAC>CAC	p.D745H		NM_014652	NP_055467	O94829	IPO13_HUMAN	importin 13	745	HEAT 13.				protein import into nucleus	cytoplasm|nucleus	protein binding|protein transporter activity			central_nervous_system(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0821)				CTCTGCTCTTGACCTCACTCG	0.617		NaN											0	0	0	0.001168	0	6	60									
ATP6V0B	533	broad.mit.edu	37	1	44442265	44442265	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:44442265C>T	uc001cld.2	+	5	393	c.282C>T	c.(280-282)ATC>ATT	p.I94I	ATP6V0B_uc001clc.2_Silent_p.I94I|ATP6V0B_uc001cle.2_Silent_p.I47I|ATP6V0B_uc001clf.2_Silent_p.I47I|B4GALT2_uc001clg.2_5'Flank|B4GALT2_uc001clh.2_5'Flank	NM_004047	NP_004038	Q99437	VATO_HUMAN	ATPase, H+ transporting, lysosomal 21kDa, V0	94	Helical; (Potential).				ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	endosome membrane|integral to membrane|proton-transporting V-type ATPase, V0 domain|vacuolar membrane	hydrogen ion transmembrane transporter activity			breast(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)				CTACCAGCATCATCTTCTGTG	0.502		NaN											0	0	0	0.008291	0	8	88									
LRRC40	55631	broad.mit.edu	37	1	70618118	70618118	+	Silent	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:70618118G>C	uc001der.1	-	12	1489	c.1437C>G	c.(1435-1437)CTC>CTG	p.L479L		NM_017768	NP_060238	Q9H9A6	LRC40_HUMAN	leucine rich repeat containing 40	479	LRR 16.									ovary(1)	1						ATAAATACCTGAGATCTAAAA	0.294		NaN											0	0	0	0.001168	0	4	33									
TGFBR3	7049	broad.mit.edu	37	1	92185617	92185617	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:92185617C>T	uc001doh.2	-	9	1712	c.1246G>A	c.(1246-1248)GAG>AAG	p.E416K	TGFBR3_uc009wde.2_Missense_Mutation_p.E193K|TGFBR3_uc010osy.1_Missense_Mutation_p.E374K|TGFBR3_uc001doi.2_Missense_Mutation_p.E415K|TGFBR3_uc001doj.2_Missense_Mutation_p.E415K	NM_003243	NP_003234	Q03167	TGBR3_HUMAN	transforming growth factor, beta receptor III	416	Extracellular (Potential).				BMP signaling pathway|cardiac epithelial to mesenchymal transition|cardiac muscle cell proliferation|cell growth|cell migration|definitive erythrocyte differentiation|heart trabecula formation|immune response|intracellular protein kinase cascade|liver development|negative regulation of cellular component movement|negative regulation of epithelial cell proliferation|palate development|pathway-restricted SMAD protein phosphorylation|response to follicle-stimulating hormone stimulus|response to luteinizing hormone stimulus|response to prostaglandin E stimulus|transforming growth factor beta receptor signaling pathway|ventricular cardiac muscle tissue morphogenesis	external side of plasma membrane|extracellular space|inhibin-betaglycan-ActRII complex|integral to plasma membrane|intracellular membrane-bounded organelle	coreceptor activity|heparin binding|PDZ domain binding|SMAD binding|transforming growth factor beta binding|transforming growth factor beta receptor activity, type III|type II transforming growth factor beta receptor binding			ovary(3)	3		all_lung(203;0.00719)|Lung NSC(277;0.0268)		all cancers(265;0.0108)|Epithelial(280;0.0825)		TCTTCTCCCTCTTCATTCCAG	0.577		NaN											0	0	0	0.001984	0	7	84									
VAV3	10451	broad.mit.edu	37	1	108417594	108417594	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:108417594C>T	uc001dvk.1	-	2	304	c.250G>A	c.(250-252)GAG>AAG	p.E84K	VAV3_uc010ouw.1_Missense_Mutation_p.E84K|VAV3_uc001dvl.1_5'UTR|VAV3_uc010oux.1_Missense_Mutation_p.E84K	NM_006113	NP_006104	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor isoform	84	CH.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(5)|lung(2)|breast(2)	9		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		CCAAACGTCTCACAACAGGCC	0.358		NaN											0	0	0	0.004482	0	7	54									
AKNAD1	254268	broad.mit.edu	37	1	109366068	109366068	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:109366068C>T	uc001dwa.2	-	13	2360	c.2091G>A	c.(2089-2091)CAG>CAA	p.Q697Q	AKNAD1_uc010ovb.1_Silent_p.Q404Q|AKNAD1_uc001dwb.2_RNA	NM_152763	NP_689976	Q5T1N1	AKND1_HUMAN	hypothetical protein LOC254268	697										ovary(3)	3						TTGAGTAATTCTGTCCTGGAG	0.408		NaN											0	0	0	0.00308	0	7	70									
KCND3	3752	broad.mit.edu	37	1	112524975	112524975	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:112524975G>A	uc001ebu.1	-	2	854	c.374C>T	c.(373-375)CCG>CTG	p.P125L	KCND3_uc001ebv.1_Missense_Mutation_p.P125L	NM_004980	NP_004971	Q9UK17	KCND3_HUMAN	potassium voltage-gated channel, Shal-related	125	Cytoplasmic (Potential).					sarcolemma|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|metal ion binding			ovary(2)|large_intestine(1)	3		all_cancers(81;8.52e-06)|all_epithelial(167;5.65e-06)|all_lung(203;2.72e-05)|Lung NSC(69;4.56e-05)		all cancers(265;0.056)|Lung(183;0.0576)|Colorectal(144;0.1)|Epithelial(280;0.104)|COAD - Colon adenocarcinoma(174;0.222)|LUSC - Lung squamous cell carcinoma(189;0.231)		GATGATCTCCGGGAGGATGCC	0.617		NaN											0	0	0	0.006214	0	9	103									
SLC16A1	6566	broad.mit.edu	37	1	113459918	113459918	+	Silent	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:113459918G>C	uc001ecx.2	-	4	1942	c.1110C>G	c.(1108-1110)CTC>CTG	p.L370L	SLC16A1_uc001ecy.2_Silent_p.L370L|SLC16A1_uc001ecz.2_Silent_p.L370L	NM_003051	NP_003042	P53985	MOT1_HUMAN	solute carrier family 16, member 1	370	Helical; (Potential).				blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	integral to membrane|membrane fraction|plasma membrane	mevalonate transmembrane transporter activity|protein binding|secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)	1	Lung SC(450;0.246)	all_cancers(81;7.6e-08)|all_epithelial(167;3.82e-07)|all_lung(203;3.07e-05)|Lung NSC(69;5.51e-05)|Prostate(1639;0.00232)		Epithelial(280;7.31e-13)|all cancers(265;5.1e-10)|Kidney(133;5.29e-07)|KIRC - Kidney renal clear cell carcinoma(1967;8.63e-06)|OV - Ovarian serous cystadenocarcinoma(397;1.48e-05)|BRCA - Breast invasive adenocarcinoma(282;0.003)|LUSC - Lung squamous cell carcinoma(189;0.008)|Lung(183;0.00948)|Colorectal(144;0.0325)|COAD - Colon adenocarcinoma(174;0.0643)	Pyruvic acid(DB00119)	ATACGGAGCTGAGCCACCCGA	0.488		NaN											0	0	0	0.009096	0	3	51									
MAGI3	260425	broad.mit.edu	37	1	114226103	114226103	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:114226103G>A	uc001edk.2	+	21	4094	c.3913G>A	c.(3913-3915)GAG>AAG	p.E1305K	MAGI3_uc001edi.3_3'UTR|MAGI3_uc010owm.1_3'UTR|MAGI3_uc001edj.2_3'UTR|MAGI3_uc009wgo.2_RNA	NM_001142782	NP_001136254	Q5TCQ9	MAGI3_HUMAN	membrane-associated guanylate kinase-related  3	1330					apoptosis|interspecies interaction between organisms|intracellular signal transduction	nucleus|tight junction	ATP binding|guanylate kinase activity|protein binding			lung(3)|ovary(2)|central_nervous_system(1)	6	Lung SC(450;0.184)	all_cancers(81;2.34e-09)|all_epithelial(167;7.41e-09)|all_lung(203;7.13e-06)|Lung NSC(69;1.2e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		ATCAAATGCTGAGGCCAAATT	0.478		NaN											0	0	0	0.00308	0	7	94									
PTPN22	26191	broad.mit.edu	37	1	114380651	114380651	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:114380651C>T	uc001eds.2	-	13	1501	c.1371G>A	c.(1369-1371)CAG>CAA	p.Q457Q	PTPN22_uc009wgq.2_Silent_p.Q402Q|PTPN22_uc010owo.1_Silent_p.Q213Q|PTPN22_uc001edt.2_Intron|PTPN22_uc009wgr.2_Silent_p.Q457Q|PTPN22_uc009wgs.2_Silent_p.Q330Q|PTPN22_uc001edu.2_Silent_p.Q457Q	NM_015967	NP_057051	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type	457					negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			kidney(2)|lung(1)|skin(1)	4	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TGGTTTCTCTCTGCTGTATCA	0.373		NaN											0	0	0	0.008291	0	8	90									
PTPN22	26191	broad.mit.edu	37	1	114380755	114380755	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:114380755C>G	uc001eds.2	-	13	1397	c.1267G>C	c.(1267-1269)GAG>CAG	p.E423Q	PTPN22_uc009wgq.2_Missense_Mutation_p.E368Q|PTPN22_uc010owo.1_Missense_Mutation_p.E179Q|PTPN22_uc001edt.2_Intron|PTPN22_uc009wgr.2_Missense_Mutation_p.E423Q|PTPN22_uc009wgs.2_Missense_Mutation_p.E296Q|PTPN22_uc001edu.2_Missense_Mutation_p.E423Q	NM_015967	NP_057051	Q9Y2R2	PTN22_HUMAN	protein tyrosine phosphatase, non-receptor type	423					negative regulation of T cell activation|negative regulation of T cell receptor signaling pathway|phosphoanandamide dephosphorylation|regulation of B cell receptor signaling pathway|regulation of natural killer cell proliferation|T cell differentiation	internal side of plasma membrane|nucleus|perinuclear region of cytoplasm	kinase binding|protein tyrosine phosphatase activity|SH3 domain binding			kidney(2)|lung(1)|skin(1)	4	Lung SC(450;0.184)	all_cancers(81;1.93e-08)|all_epithelial(167;4.37e-08)|all_lung(203;5.22e-06)|Lung NSC(69;8.94e-06)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GAACATCCCTCAAACAAAAGA	0.388		NaN											0	0	0	0.004482	0	5	63									
PTGFRN	5738	broad.mit.edu	37	1	117504176	117504176	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:117504176G>C	uc001egv.1	+	5	1662	c.1525G>C	c.(1525-1527)GAC>CAC	p.D509H		NM_020440	NP_065173	Q9P2B2	FPRP_HUMAN	prostaglandin F2 receptor negative regulator	509	Extracellular (Potential).|Ig-like C2-type 4.					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	protein binding			liver(1)	1	Lung SC(450;0.225)	all_cancers(81;0.00104)|all_lung(203;8.97e-05)|all_epithelial(167;0.000139)|Lung NSC(69;0.000446)		Lung(183;0.0704)|LUSC - Lung squamous cell carcinoma(189;0.227)|Colorectal(144;0.248)		TACAGAGGAAGACAGAGGCAA	0.463		NaN											0	0	0	0.001984	0	6	89									
MAN1A2	10905	broad.mit.edu	37	1	118039474	118039474	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:118039474G>A	uc001ehd.1	+	10	2095	c.1374G>A	c.(1372-1374)GGG>GGA	p.G458G	MAN1A2_uc009whg.1_Silent_p.G248G	NM_006699	NP_006690	O60476	MA1A2_HUMAN	mannosidase, alpha, class 1A, member 2	458	Lumenal (Potential).				N-glycan processing|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|integral to membrane|membrane fraction	calcium ion binding|mannosyl-oligosaccharide 1,2-alpha-mannosidase activity				0	Lung SC(450;0.225)	all_cancers(81;7.9e-06)|all_epithelial(167;7.39e-07)|all_lung(203;2.84e-06)|Lung NSC(69;1.99e-05)		Lung(183;0.0688)|Kidney(133;0.114)|LUSC - Lung squamous cell carcinoma(189;0.223)|KIRC - Kidney renal clear cell carcinoma(1967;0.237)|Colorectal(144;0.243)		AAAAGATGGGGCATTTGGCCT	0.438		NaN											0	0	0	0.00499	0	15	118									
HAO2	51179	broad.mit.edu	37	1	119936422	119936422	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:119936422G>T	uc001ehq.1	+	9	1367	c.1015G>T	c.(1015-1017)GCT>TCT	p.A339S	HAO2_uc001ehr.1_Missense_Mutation_p.A339S	NM_001005783	NP_001005783	Q9NYQ3	HAOX2_HUMAN	hydroxyacid oxidase 2	339	FMN hydroxy acid dehydrogenase.				fatty acid alpha-oxidation	peroxisome	(S)-2-hydroxy-acid oxidase activity			ovary(2)|skin(2)	4	all_neural(166;0.187)	all_lung(203;1.06e-06)|Lung NSC(69;7.5e-06)|all_epithelial(167;0.000284)		Lung(183;0.0155)|LUSC - Lung squamous cell carcinoma(189;0.0856)		CCGGTCGGTCGCTGAGATCAA	0.478		NaN											1	0	0.000151284	0.001855	0.000157588	11	168									
NBPF9	400818	broad.mit.edu	37	1	144617158	144617158	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:144617158G>T	uc009wig.1	+	5	260	c.184G>T	c.(184-186)GAG>TAG	p.E62*	NBPF9_uc010oxn.1_Intron|NBPF9_uc010oxo.1_Intron|NBPF9_uc010oxr.1_Intron|NBPF9_uc010oxt.1_Intron|NBPF9_uc001ekg.1_Intron|NBPF9_uc001ekk.1_Intron|NBPF10_uc009wir.2_Intron|NBPF9_uc010oyd.1_Intron|NBPF9_uc010oye.1_5'UTR|NBPF9_uc001eli.3_Intron|NBPF9_uc010oyf.1_5'UTR|NBPF9_uc010oyg.1_Intron|NBPF9_uc009wii.1_Intron	NM_001037675	NP_001032764	Q3BBV1	NBPFK_HUMAN	hypothetical protein LOC400818	62						cytoplasm					0						AGAGTATGAAGAGTGTAAAGA	0.527		NaN											1	0	0.000958276	0.007413	0.000986218	15	157									
PDE4DIP	9659	broad.mit.edu	37	1	144871824	144871824	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:144871824G>A	uc001elw.3	-	32	5429	c.5138C>T	c.(5137-5139)TCA>TTA	p.S1713L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|PDE4DIP_uc001elk.1_Intron|PDE4DIP_uc001ell.1_Intron|PDE4DIP_uc001elm.3_Intron|PDE4DIP_uc001eln.3_Intron|PDE4DIP_uc001elo.2_Intron|PDE4DIP_uc001elx.3_Intron|PDE4DIP_uc001elv.3_Missense_Mutation_p.S720L	NM_014644	NP_055459	Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein isoform	1713					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			ovary(4)|haematopoietic_and_lymphoid_tissue(1)	5				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		GGATGGAGCTGAGGGCAATGG	0.532		NaN	T	PDGFRB	MPD								0	0	0	0.00308	0	6	114									
ECM1	1893	broad.mit.edu	37	1	150483939	150483939	+	Missense_Mutation	SNP	G	G	A	rs149230481		TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:150483939G>A	uc001eus.2	+	7	914	c.715G>A	c.(715-717)GAA>AAA	p.E239K	ECM1_uc010pce.1_3'UTR|ECM1_uc010pcf.1_3'UTR|ECM1_uc001eut.2_Intron|ECM1_uc001euu.2_Missense_Mutation_p.E268K|ECM1_uc001euv.2_Missense_Mutation_p.E266K|ECM1_uc009wlu.2_5'UTR	NM_004425	NP_004416	Q16610	ECM1_HUMAN	extracellular matrix protein 1 isoform 1	239	2 X approximate repeats.|1.				angiogenesis|biomineral tissue development|negative regulation of bone mineralization|negative regulation of peptidase activity|ossification|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade	proteinaceous extracellular matrix	laminin binding|protease binding|protein C-terminus binding|signal transducer activity			ovary(2)|central_nervous_system(1)	3	all_cancers(9;3.13e-53)|all_epithelial(9;3.74e-43)|all_lung(15;2.43e-34)|Lung NSC(24;8.86e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0757)|all cancers(9;1.29e-21)|BRCA - Breast invasive adenocarcinoma(12;0.000734)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			CTAGTGGGAGGAAGCAATGAG	0.597		NaN											0	0	0	0.010818	0	26	177									
FLG2	388698	broad.mit.edu	37	1	152324512	152324512	+	Missense_Mutation	SNP	T	T	C	rs150834303		TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:152324512T>C	uc001ezw.3	-	3	5823	c.5750A>G	c.(5749-5751)AAG>AGG	p.K1917R	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	1917							calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TTGGTGTCTCTTGTGAACTGT	0.502		NaN											0	0	0	0.010504	0	19	269									
INTS3	65123	broad.mit.edu	37	1	153701122	153701122	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:153701122G>A	uc009wom.2	+	2	233	c.12G>A	c.(10-12)CAG>CAA	p.Q4Q	INTS3_uc001fct.2_Silent_p.Q4Q|INTS3_uc001fcu.2_5'UTR|INTS3_uc001fcv.2_5'UTR	NM_023015	NP_075391	Q68E01	INT3_HUMAN	integrator complex subunit 3	4					DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			TGGAGTTGCAGAAGGGAAAAG	0.448		NaN											0	0	0	0.006214	0	8	68									
INTS3	65123	broad.mit.edu	37	1	153701160	153701160	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:153701160G>T	uc009wom.2	+	2	271	c.50G>T	c.(49-51)GGA>GTA	p.G17V	INTS3_uc001fct.2_Missense_Mutation_p.G17V|INTS3_uc001fcu.2_5'UTR|INTS3_uc001fcv.2_5'UTR	NM_023015	NP_075391	Q68E01	INT3_HUMAN	integrator complex subunit 3	17	Ala/Gly-rich.				DNA repair|G2/M transition checkpoint|response to ionizing radiation|snRNA processing	integrator complex|SOSS complex	protein binding			ovary(2)|upper_aerodigestive_tract(1)	3	all_lung(78;3.75e-32)|Lung NSC(65;1.37e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			GCTGCTTCGggagcagcggga	0.423		NaN											1	0	1.58986e-06	0.008291	1.70343e-06	8	47									
GATAD2B	57459	broad.mit.edu	37	1	153784519	153784519	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:153784519C>T	uc001fdb.3	-	9	1753	c.1509G>A	c.(1507-1509)ATG>ATA	p.M503I		NM_020699	NP_065750	Q8WXI9	P66B_HUMAN	GATA zinc finger domain containing 2B	503						nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0	all_lung(78;1.34e-32)|Lung NSC(65;1.04e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			TATGATGTCTCATGATGGTCT	0.458		NaN											0	0	0	0.003163	0	9	155									
AQP10	89872	broad.mit.edu	37	1	154296214	154296214	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:154296214C>T	uc001feu.2	+	5	679	c.639C>T	c.(637-639)CTC>CTT	p.L213L	AQP10_uc001fev.2_Silent_p.L213L|ATP8B2_uc001few.2_5'Flank	NM_080429	NP_536354	Q96PS8	AQP10_HUMAN	aquaporin 10	213	Extracellular (Potential).				response to toxin|transmembrane transport|water transport	integral to membrane|plasma membrane	transporter activity			central_nervous_system(1)	1	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GGATTCCACTCAACCCTGCCC	0.642		NaN											0	0	0	0.00308	0	6	71									
DAP3	7818	broad.mit.edu	37	1	155695260	155695260	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:155695260C>G	uc001flq.2	+	5	527	c.358C>G	c.(358-360)CCA>GCA	p.P120A	DAP3_uc001flr.2_Missense_Mutation_p.P120A|DAP3_uc001fls.2_Missense_Mutation_p.P120A|DAP3_uc010pgl.1_Missense_Mutation_p.P79A|DAP3_uc001flt.2_Missense_Mutation_p.P86A|DAP3_uc001flu.2_Missense_Mutation_p.P120A|DAP3_uc010pgm.1_Missense_Mutation_p.P86A	NM_033657	NP_387506	P51398	RT29_HUMAN	death-associated protein 3	120					induction of apoptosis by extracellular signals	mitochondrial ribosome|nucleolus|small ribosomal subunit	protein binding			ovary(1)	1	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					TTTTGCTTATCCAGCTATACG	0.428		NaN											0	0	0	0.009535	0	25	160									
PMF1	11243	broad.mit.edu	37	1	156182917	156182917	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:156182917C>T	uc001fnq.2	+	1	134	c.111C>T	c.(109-111)CTC>CTT	p.L37L	PMF1_uc009wru.1_RNA|PMF1_uc001fnr.2_Silent_p.L37L|BGLAP_uc001fns.1_Silent_p.L37L	NM_007221	NP_009152	Q6P1K2	PMF1_HUMAN	polyamine-modulated factor 1	37					cell division|chromosome segregation|mitotic prometaphase|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytosol|MIS12/MIND type complex|transcription factor complex	leucine zipper domain binding|transcription coactivator activity				0	Hepatocellular(266;0.158)					GGGTGAAGCTCCTCGACACCA	0.577		NaN											0	0	0	0.00308	0	5	52									
BCAN	63827	broad.mit.edu	37	1	156618580	156618580	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:156618580G>C	uc001fpp.2	+	6	1326	c.990G>C	c.(988-990)AAG>AAC	p.K330N	BCAN_uc001fpo.2_Missense_Mutation_p.K330N	NM_021948	NP_068767	Q96GW7	PGCB_HUMAN	brevican isoform 1	330	Link 2.				cell adhesion	anchored to membrane|proteinaceous extracellular matrix	hyaluronic acid binding|sugar binding			ovary(1)|pancreas(1)	2	all_hematologic(923;0.088)|Hepatocellular(266;0.158)					CTGGTGTCAAGACTCTCTTCC	0.617		NaN											0	0	0	0.003954	0	21	209									
OR10R2	343406	broad.mit.edu	37	1	158450115	158450115	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:158450115C>T	uc010pik.1	+	1	448	c.448C>T	c.(448-450)CTG>TTG	p.L150L	uc001fso.1_RNA	NM_001004472	NP_001004472	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R,	150	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)					TTGTCACCCTCTGCATTACCC	0.468		NaN											0	0	0	0.01441	0	53	246									
OR6N2	81442	broad.mit.edu	37	1	158747170	158747170	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:158747170G>A	uc010pir.1	-	1	256	c.256C>T	c.(256-258)CTC>TTC	p.L86F		NM_001005278	NP_001005278	Q8NGY6	OR6N2_HUMAN	olfactory receptor, family 6, subfamily N,	86	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_hematologic(112;0.0378)					TTCTCACTGAGAATATTAGAC	0.453		NaN											0	0	0	0.006214	0	9	146									
AIM2	9447	broad.mit.edu	37	1	159035904	159035904	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:159035904C>G	uc001ftj.1	-	4	857	c.612G>C	c.(610-612)AAG>AAC	p.K204N		NM_004833	NP_004824	O14862	AIM2_HUMAN	absent in melanoma 2	204	HIN-200.				cellular response to drug|immune response|interleukin-1 beta secretion	mitochondrion|nucleus				ovary(2)|pancreas(1)	3	all_hematologic(112;0.0429)					TAATTATTCTCTTTGGAATGA	0.358		NaN											0	0	0	0.008291	0	11	81									
OR10J3	441911	broad.mit.edu	37	1	159284097	159284097	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:159284097A>G	uc010piu.1	-	1	353	c.353T>C	c.(352-354)GTC>GCC	p.V118A		NM_001004467	NP_001004467	Q5JRS4	O10J3_HUMAN	olfactory receptor, family 10, subfamily J,	118	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	all_hematologic(112;0.0429)					ATATCCCATGACTGTGAGCAG	0.522		NaN											0	0	0	0.013537	0	9	118									
VANGL2	57216	broad.mit.edu	37	1	160388962	160388962	+	Silent	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:160388962C>G	uc001fwb.1	+	5	662	c.363C>G	c.(361-363)CTC>CTG	p.L121L	VANGL2_uc001fwc.1_Silent_p.L121L	NM_020335	NP_065068	Q9ULK5	VANG2_HUMAN	vang-like 2	121	Helical; Name=1; (Potential).				apical protein localization|heart looping|nonmotile primary cilium assembly	apical plasma membrane|integral to membrane				ovary(1)	1	all_cancers(52;1.08e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			TGTCTTTCCTCACGCCTCTGG	0.662		NaN											0	0	0	0.00308	0	6	110									
C1orf111	284680	broad.mit.edu	37	1	162343919	162343919	+	Silent	SNP	G	G	A	rs144886006		TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:162343919G>A	uc001gbx.2	-	3	769	c.705C>T	c.(703-705)CTC>CTT	p.L235L		NM_182581	NP_872387	Q5T0L3	CA111_HUMAN	hypothetical protein LOC284680	235										ovary(1)	1	all_hematologic(112;0.15)		BRCA - Breast invasive adenocarcinoma(70;0.0938)			TGCCGGAGGAGAGCCTGTCTC	0.552		NaN											0	0	0	0.010729	0	10	243									
UAP1	6675	broad.mit.edu	37	1	162549315	162549315	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:162549315C>T	uc001gce.3	+	4	912	c.583C>T	c.(583-585)CAG>TAG	p.Q195*		NM_003115	NP_003106	Q16222	UAP1_HUMAN	UDP-N-acetylglucosamine pyrophosphorylase 1	195					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol|nucleus|plasma membrane	UDP-N-acetylglucosamine diphosphorylase activity			ovary(2)|skin(2)|kidney(1)	5	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			AATCTTTTTTCAGCAAGGAAT	0.358		NaN											0	0	0	0.006214	0	9	68									
RXRG	6258	broad.mit.edu	37	1	165380319	165380319	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:165380319C>T	uc001gda.2	-	5	950	c.650G>A	c.(649-651)CGA>CAA	p.R217Q		NM_006917	NP_008848	P48443	RXRG_HUMAN	retinoid X receptor, gamma isoform a	217	Hinge.				regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	retinoid-X receptor activity|sequence-specific DNA binding transcription factor activity|steroid binding|steroid hormone receptor activity|zinc ion binding				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				Acitretin(DB00459)|Adapalene(DB00210)|Alitretinoin(DB00523)|Etretinate(DB00926)|Tretinoin(DB00755)	AGCTCGCTCTCGGCTCCTCTG	0.448		NaN											0	0	0	0.012319	0	19	57									
FMO3	2328	broad.mit.edu	37	1	171080103	171080103	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:171080103C>T	uc001ghi.2	+	6	903	c.792C>T	c.(790-792)TTC>TTT	p.F264F	FMO3_uc001ghh.2_Silent_p.F264F|FMO3_uc010pmb.1_Silent_p.F244F|FMO3_uc010pmc.1_Silent_p.F201F	NM_001002294	NP_001002294	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	264					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					ATGCAAGATTCAAGCATGAAA	0.443		NaN											0	0	0	0.004482	0	6	100									
CEP350	9857	broad.mit.edu	37	1	179989421	179989421	+	Silent	SNP	A	A	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:179989421A>C	uc001gnt.2	+	12	2895	c.2512A>C	c.(2512-2514)AGA>CGA	p.R838R	CEP350_uc009wxl.2_Silent_p.R837R|CEP350_uc001gnu.2_Silent_p.R672R	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	838						centrosome|nucleus|spindle				ovary(4)	4						TTTGTCCAGCAGAATTGAAAG	0.443		NaN											0	0	0	0.014323	0	20	126									
HMCN1	83872	broad.mit.edu	37	1	185969231	185969231	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:185969231G>A	uc001grq.1	+	26	4158	c.3929G>A	c.(3928-3930)AGA>AAA	p.R1310K		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	1310	Ig-like C2-type 10.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						TTGACAGGCAGAGAGCCTGGC	0.398		NaN											0	0	0	0.004007	0	12	81									
CFH	3075	broad.mit.edu	37	1	196697623	196697623	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:196697623G>C	uc001gtj.3	+	15	2624	c.2384G>C	c.(2383-2385)GGA>GCA	p.G795A		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	795	Sushi 13.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						TGCATAAATGGAAGATGGGAT	0.338		NaN											0	0	0	0.004482	0	6	85									
TNNI1	7135	broad.mit.edu	37	1	201383732	201383732	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:201383732C>T	uc010ppq.1	-	5	196	c.103G>A	c.(103-105)GAG>AAG	p.E35K	TNNI1_uc001gwo.1_RNA|TNNI1_uc001gwp.2_Missense_Mutation_p.E14K	NM_003281	NP_003272	P19237	TNNI1_HUMAN	troponin I, skeletal, slow	35	Involved in binding TNC.				muscle filament sliding|regulation of striated muscle contraction	cytosol|troponin complex	actin binding|tropomyosin binding				0						TCGCGCTCCTCGTGCTCCTGC	0.662		NaN											0	0	0	0.001984	0	6	46									
DSTYK	25778	broad.mit.edu	37	1	205138805	205138805	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:205138805C>G	uc001hbw.2	-	3	874	c.810G>C	c.(808-810)AAG>AAC	p.K270N	DSTYK_uc001hbx.2_Missense_Mutation_p.K270N|DSTYK_uc001hby.1_Intron	NM_015375	NP_056190	Q6XUX3	DUSTY_HUMAN	receptor interacting protein kinase 5 isoform 1	270						cytoplasm	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(1)	1						AGGAGAAATACTTTCGGATTT	0.448		NaN											0	0	0	0.009096	0	3	55									
RPS6KC1	26750	broad.mit.edu	37	1	213405500	213405500	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:213405500G>C	uc010ptr.1	+	10	1286	c.1127G>C	c.(1126-1128)AGA>ACA	p.R376T	RPS6KC1_uc001hkd.2_Missense_Mutation_p.R364T|RPS6KC1_uc010pts.1_Missense_Mutation_p.R164T|RPS6KC1_uc010ptt.1_Missense_Mutation_p.R164T|RPS6KC1_uc010ptu.1_Missense_Mutation_p.R195T|RPS6KC1_uc010ptv.1_Intron|RPS6KC1_uc001hke.2_Missense_Mutation_p.R195T	NM_012424	NP_036556	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide	376	Protein kinase 1.				cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			lung(4)|ovary(3)|breast(1)	8				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		AGCAGGAACAGAAAGACCATC	0.413		NaN											0	0	0	0.008291	0	10	88									
KCTD3	51133	broad.mit.edu	37	1	215768802	215768802	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:215768802C>G	uc001hks.2	+	10	1216	c.922C>G	c.(922-924)CAG>GAG	p.Q308E	KCTD3_uc001hkt.2_Missense_Mutation_p.Q308E|KCTD3_uc010pub.1_Missense_Mutation_p.Q206E|KCTD3_uc009xdn.2_Missense_Mutation_p.Q60E	NM_016121	NP_057205	Q9Y597	KCTD3_HUMAN	potassium channel tetramerisation domain	308	WD 2.					voltage-gated potassium channel complex	protein binding|voltage-gated potassium channel activity			ovary(3)	3				all cancers(67;0.0164)|OV - Ovarian serous cystadenocarcinoma(81;0.019)|GBM - Glioblastoma multiforme(131;0.0862)|Epithelial(68;0.13)		TGCTGTCACTCAGCACTGGCA	0.403		NaN											0	0	0	0.001168	0	6	64									
USH2A	7399	broad.mit.edu	37	1	216500943	216500943	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:216500943G>T	uc001hku.1	-	5	1225	c.838C>A	c.(838-840)CTT>ATT	p.L280I	USH2A_uc001hkv.2_Missense_Mutation_p.L280I	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	280	Laminin N-terminal.|Extracellular (Potential).		L -> F (in USH2A).		maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		CTGTTTGTAAGTGCCACTTGG	0.343		NaN								HNSCC(13;0.011)			1	0	0.00010058	0.013537	0.000104953	11	109									
C1orf131	128061	broad.mit.edu	37	1	231364906	231364906	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:231364906T>A	uc001hun.1	-	3	537	c.500A>T	c.(499-501)AAC>ATC	p.N167I	C1orf131_uc001hul.2_Missense_Mutation_p.N167I|C1orf131_uc001hum.2_Missense_Mutation_p.N166I|C1orf131_uc010pwd.1_Missense_Mutation_p.N166I	NM_152379	NP_689592	Q8NDD1	CA131_HUMAN	hypothetical protein LOC128061	167										central_nervous_system(1)|skin(1)	2	Breast(184;0.0871)	all_cancers(173;0.2)|Prostate(94;0.183)				TTTTTCTAGGTTAAATTCTTG	0.199		NaN											0	0	0	0.009096	0	3	38									
LYST	1130	broad.mit.edu	37	1	235969823	235969823	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:235969823G>A	uc001hxj.2	-	6	2788	c.2613C>T	c.(2611-2613)CTC>CTT	p.L871L	LYST_uc009xgb.1_RNA|LYST_uc010pxs.1_RNA|LYST_uc001hxl.1_Silent_p.L871L	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	871					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			AAAATTTGCTGAGACTCTGAG	0.398		NaN							Chediak-Higashi_syndrome				0	0	0	0.003163	0	14	106									
RYR2	6262	broad.mit.edu	37	1	237819281	237819281	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:237819281C>G	uc001hyl.1	+	53	8246	c.8126C>G	c.(8125-8127)TCA>TGA	p.S2709*		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2709	Modulator (Potential).|Cytoplasmic (By similarity).|3.|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GTTGATACCTCAAAGTATGGA	0.358		NaN											0	0	0	0.00308	0	5	22									
OPN3	23596	broad.mit.edu	37	1	241803278	241803278	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:241803278G>A	uc001hza.2	-	1	424	c.279C>T	c.(277-279)TTC>TTT	p.F93F	OPN3_uc001hzb.2_RNA|OPN3_uc001hzc.2_RNA	NM_014322	NP_055137	Q9H1Y3	OPN3_HUMAN	opsin 3	93	Helical; Name=2; (Potential).				phototransduction|protein-chromophore linkage|regulation of circadian rhythm|visual perception	integral to plasma membrane	G-protein coupled photoreceptor activity				0	Ovarian(103;0.103)|all_lung(81;0.23)	all_cancers(173;0.0231)	OV - Ovarian serous cystadenocarcinoma(106;0.0125)			AGGTGACCCCGAAGAGGGACA	0.622		NaN											0	0	0	0.000602	0	4	18									
OR2M4	26245	broad.mit.edu	37	1	248402892	248402892	+	Missense_Mutation	SNP	T	T	A	rs138162512		TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:248402892T>A	uc010pzh.1	+	1	662	c.662T>A	c.(661-663)GTC>GAC	p.V221D		NM_017504	NP_059974	Q96R27	OR2M4_HUMAN	olfactory receptor, family 2, subfamily M,	221	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)	2	all_cancers(71;0.000124)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TATTCCCATGTCCTTCGAGCC	0.483		NaN											0	0	0	0.001984	0	7	48									
OR2T2	401992	broad.mit.edu	37	1	248616329	248616329	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:248616329C>T	uc001iek.1	+	1	231	c.231C>T	c.(229-231)ATC>ATT	p.I77I		NM_001004136	NP_001004136	Q6IF00	OR2T2_HUMAN	olfactory receptor, family 2, subfamily T,	77	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ACATCTGTATCACTGTCCCCA	0.522		NaN											0	0	0	0.006214	0	6	164									
KLF6	1316	broad.mit.edu	37	10	3823941	3823941	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:3823941C>T	uc001iha.2	-	2	835	c.568G>A	c.(568-570)GAT>AAT	p.D190N	KLF6_uc010qaj.1_Missense_Mutation_p.D190N|KLF6_uc010qak.1_Intron|KLF6_uc010qal.1_Intron|KLF6_uc001ihb.2_Missense_Mutation_p.D190N	NM_001300	NP_001291	Q99612	KLF6_HUMAN	Kruppel-like factor 6 isoform A	190					B cell differentiation	nucleus	zinc ion binding			central_nervous_system(3)|lung(1)	4				Colorectal(1;0.238)		GGGGAGGCATCGCCATTTCCC	0.627		NaN									OREG0019980	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001855	0	12	57									
KLF6	1316	broad.mit.edu	37	10	3824047	3824047	+	Silent	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:3824047C>G	uc001iha.2	-	2	729	c.462G>C	c.(460-462)CTG>CTC	p.L154L	KLF6_uc010qaj.1_Silent_p.L154L|KLF6_uc010qak.1_RNA|KLF6_uc010qal.1_Silent_p.L154L|KLF6_uc001ihb.2_Silent_p.L154L	NM_001300	NP_001291	Q99612	KLF6_HUMAN	Kruppel-like factor 6 isoform A	154					B cell differentiation	nucleus	zinc ion binding			central_nervous_system(3)|lung(1)	4				Colorectal(1;0.238)		GTTCCCTGCTCAGTTCCGGAG	0.612		NaN									OREG0019980	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00245	0	13	73									
C10orf18	54906	broad.mit.edu	37	10	5791660	5791660	+	Silent	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:5791660C>G	uc001iij.2	+	15	6901	c.6276C>G	c.(6274-6276)CTC>CTG	p.L2092L	C10orf18_uc001iik.2_Silent_p.L936L	NM_017782	NP_060252	Q5VWN6	CJ018_HUMAN	hypothetical protein LOC54906	2092										ovary(1)|central_nervous_system(1)	2						CATTCCACCTCAACAAACTGA	0.383		NaN											0	0	0	0.000602	0	4	37									
FAM171A1	221061	broad.mit.edu	37	10	15296770	15296770	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:15296770G>A	uc001iob.2	-	4	534	c.527C>T	c.(526-528)TCG>TTG	p.S176L		NM_001010924	NP_001010924	Q5VUB5	F1711_HUMAN	hypothetical protein LOC221061 precursor	176	Extracellular (Potential).					integral to membrane				ovary(2)|breast(1)|skin(1)	4						GTCCACCTCCGAAGGGGAGCT	0.507		NaN											0	0	0	0.001168	0	5	32									
CUBN	8029	broad.mit.edu	37	10	17107611	17107611	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:17107611G>A	uc001ioo.2	-	22	3087	c.3035C>T	c.(3034-3036)TCT>TTT	p.S1012F		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1012	CUB 5.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GCTTGTGAGAGATGGCGGGAT	0.403		NaN											0	0	0	0.004656	0	19	161									
SVIL	6840	broad.mit.edu	37	10	29747179	29747179	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:29747179G>A	uc001iut.1	-	38	7395	c.6642C>T	c.(6640-6642)TTC>TTT	p.F2214F	LOC387647_uc001iuo.1_Intron|LOC387647_uc001iup.2_Intron|LOC387647_uc001iuq.1_Intron|SVIL_uc010qdw.1_Silent_p.F1128F|SVIL_uc001iuu.1_Silent_p.F1788F	NM_021738	NP_068506	O95425	SVIL_HUMAN	supervillin isoform 2	2214	HP.				cytoskeleton organization|skeletal muscle tissue development	cell junction|costamere|invadopodium|nucleus|podosome	actin filament binding			ovary(5)|upper_aerodigestive_tract(1)	6		Breast(68;0.103)				TCCCCACTCAGAACAGGCCTT	0.502		NaN											0	0	0	0.000602	0	3	62									
KIAA1462	57608	broad.mit.edu	37	10	30336610	30336610	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:30336610C>T	uc001iux.2	-	1	191	c.132G>A	c.(130-132)CAG>CAA	p.Q44Q	KIAA1462_uc001iuy.2_Silent_p.Q44Q|KIAA1462_uc001iuz.2_5'UTR|KIAA1462_uc009xle.1_Silent_p.Q44Q	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	44										ovary(4)	4						CATGCCCGTTCTGCAGGCCCT	0.642		NaN											0	0	0	0.00308	0	6	41									
PARD3	56288	broad.mit.edu	37	10	34671692	34671692	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:34671692C>T	uc010qej.1	-	9	1175	c.1175G>A	c.(1174-1176)AGG>AAG	p.R392K	PARD3_uc010qek.1_Missense_Mutation_p.R392K|PARD3_uc010qel.1_Missense_Mutation_p.R392K|PARD3_uc010qem.1_Missense_Mutation_p.R392K|PARD3_uc010qen.1_Missense_Mutation_p.R392K|PARD3_uc010qeo.1_Missense_Mutation_p.R392K|PARD3_uc010qep.1_Missense_Mutation_p.R348K|PARD3_uc010qeq.1_Missense_Mutation_p.R348K|PARD3_uc001ixo.1_Missense_Mutation_p.R122K|PARD3_uc001ixp.1_Missense_Mutation_p.R257K|PARD3_uc001ixq.1_Missense_Mutation_p.R392K|PARD3_uc001ixr.1_Missense_Mutation_p.R392K|PARD3_uc001ixt.1_Missense_Mutation_p.R213K|PARD3_uc001ixu.1_Missense_Mutation_p.R348K|PARD3_uc001ixs.1_Missense_Mutation_p.R45K	NM_019619	NP_062565	Q8TEW0	PARD3_HUMAN	partitioning-defective protein 3 homolog	392					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|asymmetric cell division|axonogenesis|cell cycle|establishment of epithelial cell polarity|protein complex assembly|protein targeting to membrane|tight junction assembly	cell cortex|cytoskeleton|cytosol|endomembrane system|tight junction	phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|protein binding			ovary(1)	1		Breast(68;0.0707)				GTTCACACTCCTGTTGTCAAT	0.488		NaN											0	0	0	0.010729	0	10	75									
NCOA4	8031	broad.mit.edu	37	10	51584877	51584877	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:51584877G>C	uc001jis.3	+	8	1179	c.976G>C	c.(976-978)GAG>CAG	p.E326Q	PARG_uc001jih.2_Intron|uc010qha.1_Intron|uc001jin.2_Intron|uc010qhb.1_Intron|uc010qhc.1_Intron|NCOA4_uc009xon.2_Missense_Mutation_p.E342Q|NCOA4_uc010qhd.1_Missense_Mutation_p.E342Q|NCOA4_uc010qhe.1_Missense_Mutation_p.E226Q|NCOA4_uc010qhf.1_Missense_Mutation_p.E160Q|NCOA4_uc001jit.2_Missense_Mutation_p.E326Q|NCOA4_uc009xoo.2_Missense_Mutation_p.E326Q	NM_001145263	NP_001138735	Q13772	NCOA4_HUMAN	nuclear receptor coactivator 4 isoform 3	326					androgen receptor signaling pathway|male gonad development|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	androgen receptor binding|transcription coactivator activity			central_nervous_system(1)|kidney(1)	2						TGAAACCAGTGAGAAGTTTAA	0.478		NaN	T	RET	papillary thyroid 								0	0	0	0.001984	0	5	74									
EXOC6	54536	broad.mit.edu	37	10	94733956	94733956	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:94733956G>A	uc001kig.2	+	18	1986	c.1920G>A	c.(1918-1920)TTG>TTA	p.L640L	EXOC6_uc010qnr.1_Silent_p.L656L|EXOC6_uc001kie.2_Silent_p.L635L|EXOC6_uc009xub.2_Silent_p.L639L|EXOC6_uc009xuc.2_Silent_p.L537L|EXOC6_uc001kih.2_RNA|EXOC6_uc001kii.2_Silent_p.L214L	NM_019053	NP_061926	Q8TAG9	EXOC6_HUMAN	SEC15-like 1 isoform a	640					protein transport|vesicle docking involved in exocytosis	exocyst				skin(1)	1		Colorectal(252;0.123)				TAAATTTTTTGAGAAGCATCT	0.284		NaN											0	0	0	0.00308	0	5	56									
SORBS1	10580	broad.mit.edu	37	10	97096846	97096846	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:97096846G>A	uc001kkp.2	-	28	3116	c.3071C>T	c.(3070-3072)TCA>TTA	p.S1024L	SORBS1_uc001kkk.2_Intron|SORBS1_uc001kkl.2_Intron|SORBS1_uc001kkn.2_Intron|SORBS1_uc001kkm.2_Intron|SORBS1_uc001kko.2_Intron|SORBS1_uc001kkq.2_Intron|SORBS1_uc001kkr.2_Intron|SORBS1_uc001kks.2_Intron|SORBS1_uc001kkt.2_Intron|SORBS1_uc001kku.2_Intron|SORBS1_uc001kkv.2_Intron|SORBS1_uc001kkw.2_Missense_Mutation_p.S978L|SORBS1_uc010qoe.1_Intron	NM_001034954	NP_001030126	Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1 isoform 3	1024					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			breast(1)	1		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		GGCCCTTGGTGACAAGGCGAG	0.607		NaN											0	0	0	0.001855	0	11	26									
SORBS1	10580	broad.mit.edu	37	10	97174257	97174257	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:97174257C>T	uc001kkp.2	-	7	849	c.804G>A	c.(802-804)TCG>TCA	p.S268S	SORBS1_uc001kkl.2_5'UTR|SORBS1_uc001kkn.2_Intron|SORBS1_uc001kkm.2_Intron|SORBS1_uc001kko.2_Silent_p.S268S|SORBS1_uc001kkq.2_Silent_p.S199S|SORBS1_uc001kkr.2_Intron|SORBS1_uc001kks.2_Intron|SORBS1_uc001kkt.2_RNA|SORBS1_uc001kku.2_Intron|SORBS1_uc001kkv.2_Silent_p.S236S|SORBS1_uc001kkw.2_Silent_p.S268S|SORBS1_uc010qoe.1_Intron|SORBS1_uc010qof.1_Silent_p.S466S|SORBS1_uc001kkx.1_Silent_p.S236S	NM_001034954	NP_001030126	Q9BX66	SRBS1_HUMAN	sorbin and SH3 domain containing 1 isoform 3	268					focal adhesion assembly|glucose transport|insulin receptor signaling pathway|muscle contraction|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of lipid biosynthetic process|stress fiber assembly	centrosome|cytosol|focal adhesion|membrane raft|nucleus|stress fiber|zonula adherens	actin binding|insulin receptor binding|SH3/SH2 adaptor activity			breast(1)	1		Colorectal(252;0.0429)		Epithelial(162;1.7e-06)|all cancers(201;6.52e-05)		TTACGGTACTCGAAACAGCTC	0.602		NaN											0	0	0	0.008291	0	10	63									
GBF1	8729	broad.mit.edu	37	10	104111130	104111130	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:104111130A>T	uc001kux.1	+	5	653	c.413A>T	c.(412-414)CAG>CTG	p.Q138L	GBF1_uc001kuw.2_Missense_Mutation_p.Q138L|GBF1_uc001kuy.1_Missense_Mutation_p.Q138L|GBF1_uc001kuz.1_Missense_Mutation_p.Q138L	NM_004193	NP_004184	Q92538	GBF1_HUMAN	golgi-specific brefeldin A resistant guanine	138					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		AAAATCCTTCAGGTAAGCGAG	0.517		NaN											0	0	0	0.004482	0	8	42									
GBF1	8729	broad.mit.edu	37	10	104136749	104136749	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:104136749G>C	uc001kux.1	+	33	4583	c.4343G>C	c.(4342-4344)CGC>CCC	p.R1448P	GBF1_uc001kuy.1_Missense_Mutation_p.R1448P|GBF1_uc001kuz.1_Missense_Mutation_p.R1449P	NM_004193	NP_004184	Q92538	GBF1_HUMAN	golgi-specific brefeldin A resistant guanine	1448					COPI coating of Golgi vesicle|post-Golgi vesicle-mediated transport|regulation of ARF protein signal transduction|retrograde vesicle-mediated transport, Golgi to ER	Golgi membrane	ARF guanyl-nucleotide exchange factor activity|protein binding			ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.0236)		Epithelial(162;5.16e-08)|all cancers(201;1.19e-06)		AAAGGGAACCGCTTCAAGAAG	0.517		NaN											0	0	0	0.013537	0	12	96									
CNNM2	54805	broad.mit.edu	37	10	104678597	104678597	+	Silent	SNP	C	C	T	rs142276906	byFrequency	TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:104678597C>T	uc001kwm.2	+	1	484	c.360C>T	c.(358-360)TTC>TTT	p.F120F	CNNM2_uc001kwn.2_Silent_p.F120F|CNNM2_uc001kwl.2_Silent_p.F120F	NM_017649	NP_060119	Q9H8M5	CNNM2_HUMAN	cyclin M2 isoform 1	120					ion transport	integral to membrane				ovary(1)|central_nervous_system(1)	2		Colorectal(252;0.103)|all_hematologic(284;0.152)|Breast(234;0.198)		Epithelial(162;7.89e-09)|all cancers(201;1.82e-07)|BRCA - Breast invasive adenocarcinoma(275;0.215)		GCATCGCCTTCACCGAGCACG	0.557		NaN											0	0	0	0.009096	0	4	25									
CCDC147	159686	broad.mit.edu	37	10	106139900	106139900	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:106139900G>A	uc001kyh.2	+	9	1421	c.1287G>A	c.(1285-1287)CAG>CAA	p.Q429Q		NM_001008723	NP_001008723	Q5T655	CC147_HUMAN	coiled-coil domain containing 147	429	Potential.									ovary(2)|central_nervous_system(2)|skin(1)	5		Colorectal(252;0.103)|Breast(234;0.122)		Epithelial(162;7.55e-10)|all cancers(201;3.37e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0189)		ATGAGGCTCAGAAGCAGAGAA	0.488		NaN											0	0	0	0.007413	0	17	68									
SORCS1	114815	broad.mit.edu	37	10	108357148	108357148	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:108357148C>T	uc001kym.2	-	24	3234	c.3226G>A	c.(3226-3228)GGA>AGA	p.G1076R	SORCS1_uc001kyl.2_Missense_Mutation_p.G1076R|SORCS1_uc009xxs.2_Missense_Mutation_p.G1076R|SORCS1_uc001kyn.1_Missense_Mutation_p.G1076R|SORCS1_uc001kyo.2_Missense_Mutation_p.G1076R	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	1076	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		ACTCGGACTCCTGGCTTCAGC	0.502		NaN											0	0	0	0.009096	0	3	69									
ZDHHC6	64429	broad.mit.edu	37	10	114190585	114190585	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:114190585C>T	uc001kzv.2	-	11	1643	c.1219G>A	c.(1219-1221)GAG>AAG	p.E407K	ZDHHC6_uc001kzw.2_Missense_Mutation_p.E403K	NM_022494	NP_071939	Q9H6R6	ZDHC6_HUMAN	zinc finger, DHHC-type containing 6	407						integral to membrane	acyltransferase activity|zinc ion binding				0		Colorectal(252;0.198)		Epithelial(162;0.0291)|all cancers(201;0.117)		TTCTCCCCCTCTGGGGCTTGA	0.358		NaN											0	0	0	0.004482	0	6	74									
ATRNL1	26033	broad.mit.edu	37	10	117026389	117026389	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:117026389G>A	uc001lcg.2	+	12	2274	c.1888G>A	c.(1888-1890)GGG>AGG	p.G630R		NM_207303	NP_997186	Q5VV63	ATRN1_HUMAN	attractin-like 1 precursor	630	PSI 1.|Kelch 6.|Extracellular (Potential).					integral to membrane	sugar binding			ovary(5)|lung(1)|central_nervous_system(1)	7		all_lung(145;0.0686)|Breast(234;0.0969)|Lung NSC(174;0.17)|Colorectal(252;0.234)		Epithelial(162;0.00031)|all cancers(201;0.000753)|LUSC - Lung squamous cell carcinoma(1;0.0515)|Lung(30;0.0827)		TGCTGGTCCAGGGATAAAATG	0.363		NaN											0	0	0	0.003163	0	12	90									
RGS10	6001	broad.mit.edu	37	10	121286922	121286922	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:121286922C>G	uc001lee.2	-	1	40	c.40G>C	c.(40-42)GAT>CAT	p.D14H	RGS10_uc001lef.2_Missense_Mutation_p.D8H|RGS10_uc001leg.2_Missense_Mutation_p.D22H	NM_002925	NP_002916	O43665	RGS10_HUMAN	regulator of G-protein signaling 10 isoform b	14					negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|protein binding|signal transducer activity				0		Lung NSC(174;0.094)|all_lung(145;0.123)		all cancers(201;0.00105)|GBM - Glioblastoma multiforme(135;0.195)		GAACTGCCATCGCTGTCGTGG	0.517		NaN											0	0	0	0.013537	0	11	69									
FAM24A	118670	broad.mit.edu	37	10	124671218	124671218	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:124671218C>T	uc001lgv.2	+	2	189	c.68C>T	c.(67-69)GCG>GTG	p.A23V		NM_001029888	NP_001025059	A6NFZ4	FA24A_HUMAN	family with sequence similarity 24, member A	23						extracellular region				ovary(2)	2		all_neural(114;0.169)|Glioma(114;0.222)		Colorectal(40;0.124)|COAD - Colon adenocarcinoma(40;0.141)		CTGGTTGCCGCGATGGTGCTC	0.473		NaN											0	0	0	0.01441	0	51	284									
JAKMIP3	282973	broad.mit.edu	37	10	133978214	133978214	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:133978214G>C	uc001lkx.3	+	20	2459	c.2459G>C	c.(2458-2460)AGA>ACA	p.R820T	JAKMIP3_uc009yba.1_Missense_Mutation_p.R257T	NM_001105521	NP_001098991			Janus kinase and microtubule interacting protein											breast(1)	1		all_cancers(35;5.63e-09)|all_epithelial(44;9.25e-07)|Lung NSC(174;0.0108)|all_lung(145;0.0173)|Colorectal(31;0.0721)|all_neural(114;0.0726)|Breast(234;0.0949)|Glioma(114;0.172)|Melanoma(40;0.175)		OV - Ovarian serous cystadenocarcinoma(35;0.000104)|Epithelial(32;0.000142)|all cancers(32;0.000185)|BRCA - Breast invasive adenocarcinoma(275;0.224)		GCTCAGAAGAGACAAATAAAG	0.418		NaN											0	0	0	0.009096	0	3	26									
KNDC1	85442	broad.mit.edu	37	10	134981812	134981812	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:134981812T>C	uc001llz.1	+	3	357	c.356T>C	c.(355-357)TTT>TCT	p.F119S	KNDC1_uc001lma.1_Missense_Mutation_p.F54S	NM_152643	NP_689856	Q76NI1	VKIND_HUMAN	kinase non-catalytic C-lobe domain (KIND)	119	KIND 1.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction					upper_aerodigestive_tract(1)|ovary(1)	2		all_cancers(35;4.16e-10)|all_epithelial(44;2.07e-08)|Lung NSC(174;0.000845)|all_lung(145;0.00145)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.173)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.77e-06)|Epithelial(32;1.13e-05)|all cancers(32;1.51e-05)		GGGAACACCTTTGAGGTAAGT	0.582		NaN											0	0	0	0.001855	0	10	73									
PAOX	196743	broad.mit.edu	37	10	135197564	135197564	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:135197564C>T	uc001lmv.2	+	4	1049	c.969C>T	c.(967-969)ATC>ATT	p.I323I	PAOX_uc001lmw.2_Intron|PAOX_uc001lmx.2_Silent_p.I323I|PAOX_uc001lmy.2_Intron|PAOX_uc001lmz.2_RNA|PAOX_uc001lna.2_RNA|PAOX_uc001lnb.2_Intron|PAOX_uc001lnc.2_Intron	NM_152911	NP_690875	Q6QHF9	PAOX_HUMAN	polyamine oxidase isoform 1	461					polyamine biosynthetic process|xenobiotic metabolic process	peroxisomal matrix	polyamine oxidase activity				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		all cancers(32;4.39e-07)|OV - Ovarian serous cystadenocarcinoma(35;1.21e-06)|Epithelial(32;1.94e-06)		ACAACAAAATCTTCCTGGAGT	0.557		NaN											0	0	0	0.009096	0	4	56									
SOX6	55553	broad.mit.edu	37	11	16071318	16071318	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:16071318C>T	uc001mme.2	-	11	1490	c.1457G>A	c.(1456-1458)GGA>GAA	p.G486E	SOX6_uc001mmd.2_Missense_Mutation_p.G435E|SOX6_uc001mmf.2_Missense_Mutation_p.G432E|SOX6_uc001mmg.2_Missense_Mutation_p.G473E	NM_001145819	NP_001139291	P35712	SOX6_HUMAN	SRY (sex determining region Y)-box 6 isoform 4	473					muscle organ development	nucleus	sequence-specific DNA binding transcription factor activity			ovary(3)	3						GGATCCTCTTCCCAGGCTTCC	0.473		NaN											0	0	0	0.008871	0	19	199									
ABCC8	6833	broad.mit.edu	37	11	17428510	17428510	+	Silent	SNP	G	G	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:17428510G>T	uc001mnc.2	-	25	3213	c.3087C>A	c.(3085-3087)ATC>ATA	p.I1029I		NM_000352	NP_000343	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C, member 8	1029	ABC transmembrane type-1 2.|Extracellular (By similarity).				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	GCCAGTAGTCGATGGCCACCA	0.647		NaN											1	0	1.06961e-07	0.00308	1.15426e-07	6	97									
BDNF	627	broad.mit.edu	37	11	27679688	27679688	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:27679688C>G	uc010rdu.1	-	2	1275	c.424G>C	c.(424-426)GAC>CAC	p.D142H	BDNFOS_uc001mrm.2_Intron|BDNFOS_uc009yij.2_Intron|BDNFOS_uc009yik.2_Intron|BDNFOS_uc009yil.2_Intron|BDNFOS_uc001mrp.2_Intron|BDNFOS_uc009yim.2_Intron|BDNFOS_uc009yin.2_Intron|BDNFOS_uc009yio.2_Intron|BDNFOS_uc009yip.2_Intron|BDNFOS_uc001mrn.2_Intron|BDNFOS_uc009yiq.2_Intron|BDNFOS_uc001mro.2_Intron|BDNFOS_uc009yir.2_Intron|BDNFOS_uc009yis.2_Intron|BDNFOS_uc009yit.2_Intron|BDNFOS_uc009yiu.2_Intron|BDNFOS_uc009yiv.2_Intron|BDNFOS_uc009yiw.2_Intron|BDNFOS_uc009yix.2_Intron|BDNFOS_uc009yiy.2_Intron|BDNFOS_uc009yiz.2_Intron|BDNFOS_uc001mrq.3_Intron|BDNFOS_uc001mrr.3_Intron|BDNFOS_uc009yja.2_Intron|BDNFOS_uc009yjb.2_Intron|BDNF_uc010rdv.1_Missense_Mutation_p.D142H|BDNF_uc001mrt.2_Missense_Mutation_p.D157H|BDNF_uc010rdw.1_Missense_Mutation_p.D142H|BDNF_uc009yjd.2_Missense_Mutation_p.D142H|BDNF_uc001mru.2_Missense_Mutation_p.D142H|BDNF_uc010rdx.1_Missense_Mutation_p.D142H|BDNF_uc010rdy.1_Missense_Mutation_p.D142H|BDNF_uc009yjg.2_Missense_Mutation_p.D142H|BDNF_uc009yje.2_Missense_Mutation_p.D224H|BDNF_uc009yjf.2_Missense_Mutation_p.D171H|BDNF_uc001mrv.2_Missense_Mutation_p.D142H|BDNF_uc001mrw.3_Missense_Mutation_p.D142H|BDNF_uc001mrx.2_Missense_Mutation_p.D142H|BDNF_uc001mry.3_Missense_Mutation_p.D142H|BDNF_uc001mrz.3_Missense_Mutation_p.D142H|BDNF_uc001msa.2_Missense_Mutation_p.D150H	NM_001143816	NP_001137288	P23560	BDNF_HUMAN	brain-derived neurotrophic factor isoform a	142						extracellular region	growth factor activity				0						CTAATACTGTCACACACGCTC	0.542		NaN											0	0	0	0.008871	0	16	112									
DGKZ	8525	broad.mit.edu	37	11	46389235	46389235	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:46389235G>C	uc001ncn.1	+	4	996	c.871G>C	c.(871-873)GAG>CAG	p.E291Q	DGKZ_uc001nch.1_Missense_Mutation_p.E119Q|DGKZ_uc010rgq.1_Missense_Mutation_p.E68Q|DGKZ_uc001ncj.1_Missense_Mutation_p.E68Q|DGKZ_uc010rgr.1_Missense_Mutation_p.E67Q|DGKZ_uc001nck.1_5'UTR|DGKZ_uc001ncl.2_Missense_Mutation_p.E102Q|DGKZ_uc001ncm.2_Missense_Mutation_p.E102Q|DGKZ_uc009yky.1_Missense_Mutation_p.E102Q|DGKZ_uc010rgs.1_Missense_Mutation_p.E102Q|DGKZ_uc001nci.1_Missense_Mutation_p.E68Q	NM_001105540	NP_001099010	Q13574	DGKZ_HUMAN	diacylglycerol kinase zeta isoform 4	291	Phorbol-ester/DAG-type 1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			pancreas(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		CATCTGGTTCGAGACCAACGT	0.657		NaN									OREG0020942	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.003163	0	12	64									
DGKZ	8525	broad.mit.edu	37	11	46394037	46394037	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:46394037G>A	uc001ncn.1	+	12	1676	c.1551G>A	c.(1549-1551)CTG>CTA	p.L517L	DGKZ_uc001nch.1_Silent_p.L345L|DGKZ_uc010rgq.1_Silent_p.L272L|DGKZ_uc001ncj.1_Silent_p.L295L|DGKZ_uc010rgr.1_Silent_p.L294L|DGKZ_uc001nck.1_Silent_p.L107L|DGKZ_uc001ncl.2_Silent_p.L329L|DGKZ_uc001ncm.2_Silent_p.L328L|DGKZ_uc009yky.1_Silent_p.L329L|DGKZ_uc010rgs.1_Silent_p.L306L	NM_001105540	NP_001099010	Q13574	DGKZ_HUMAN	diacylglycerol kinase zeta isoform 4	517	DAGKc.|Mediates interaction with RASGRP1.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			pancreas(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		TCTTCGACCTGAGCCAGGGAG	0.577		NaN											0	0	0	0.008291	0	8	90									
OR4C6	219432	broad.mit.edu	37	11	55432656	55432656	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:55432656A>G	uc001nht.3	+	3	279	c.14A>G	c.(13-15)AAC>AGC	p.N5S	OR4C6_uc010rik.1_Missense_Mutation_p.N5S	NM_001004704	NP_001004704	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C,	5	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2						GAAAATCAAAACAATGTGACT	0.373		NaN											0	0	0	0.004007	0	12	80									
OR8H2	390151	broad.mit.edu	37	11	55872685	55872685	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:55872685T>G	uc010riy.1	+	1	167	c.167T>G	c.(166-168)CTT>CGT	p.L56R		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	56	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					GACCTCCAGCTTCACACTCCC	0.428		NaN								HNSCC(53;0.14)			0	0	0	0.00632	0	24	264									
OR9Q1	219956	broad.mit.edu	37	11	57947223	57947223	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:57947223C>T	uc001nmj.2	+	3	623	c.307C>T	c.(307-309)CTG>TTG	p.L103L		NM_001005212	NP_001005212	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q,	103	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.222)				TCAGTTCTTTCTGTTCACCTT	0.542		NaN											0	0	0	0.004482	0	8	64									
OR5AN1	390195	broad.mit.edu	37	11	59132579	59132579	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:59132579G>C	uc010rks.1	+	1	648	c.648G>C	c.(646-648)ATG>ATC	p.M216I		NM_001004729	NP_001004729	Q8NGI8	O5AN1_HUMAN	olfactory receptor, family 5, subfamily AN,	216	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TAGTTATCATGATATCCTATG	0.418		NaN											0	0	0	0.003163	0	11	139									
OSBP	5007	broad.mit.edu	37	11	59344488	59344488	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:59344488C>T	uc001noc.1	-	13	2551	c.2071G>A	c.(2071-2073)GAA>AAA	p.E691K	OSBP_uc009ymr.1_RNA	NM_002556	NP_002547	P22059	OSBP1_HUMAN	oxysterol binding protein	691					lipid transport	Golgi membrane	oxysterol binding			large_intestine(1)	1		all_epithelial(135;0.000236)		BRCA - Breast invasive adenocarcinoma(625;0.00607)|LUSC - Lung squamous cell carcinoma(625;0.207)		TACATGTTTTCTGCATTCTTC	0.463		NaN											0	0	0	0.004672	0	3	65									
VWCE	220001	broad.mit.edu	37	11	61034991	61034991	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:61034991G>C	uc001nra.2	-	16	2187	c.1908C>G	c.(1906-1908)TTC>TTG	p.F636L	VWCE_uc001nrb.2_RNA	NM_152718	NP_689931	Q96DN2	VWCE_HUMAN	von Willebrand factor C and EGF domains	636	VWFC 5.					extracellular region	calcium ion binding			ovary(1)	1						CGTTGTTATAGAAGATTCTGC	0.612		NaN											0	0	0	0.008291	0	8	71									
ASRGL1	80150	broad.mit.edu	37	11	62124476	62124476	+	Silent	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:62124476G>C	uc001nte.3	+	4	635	c.351G>C	c.(349-351)CTG>CTC	p.L117L	ASRGL1_uc001ntf.3_Silent_p.L117L|ASRGL1_uc001ntg.3_5'UTR|ASRGL1_uc001nth.1_RNA	NM_025080	NP_079356	Q7L266	ASGL1_HUMAN	asparaginase-like 1	117					asparagine catabolic process via L-aspartate|protein maturation	cytoplasm|microtubule cytoskeleton|nucleus	N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity				0					L-Asparagine(DB00174)|L-Aspartic Acid(DB00128)	ATTGCTTTCTGACTGACCAAG	0.398		NaN											0	0	0	0.000602	0	3	61									
UBXN1	51035	broad.mit.edu	37	11	62444099	62444099	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:62444099G>A	uc001nul.1	-	9	989	c.857C>T	c.(856-858)TCT>TTT	p.S286F	UBXN1_uc001nuj.2_3'UTR|UBXN1_uc001num.1_Missense_Mutation_p.S282F|UBXN1_uc001nuk.2_3'UTR	NM_015853	NP_056937	Q04323	UBXN1_HUMAN	UBX domain protein 1	286	UBX.|Interaction with BRCA1.				negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination|proteasomal ubiquitin-dependent protein catabolic process	cytoplasm	ATPase binding|K6-linked polyubiquitin binding				0						GAGAACAGCAGAAGGCACGAG	0.483		NaN											0	0	0	0.004672	0	3	6									
NRXN2	9379	broad.mit.edu	37	11	64435996	64435996	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:64435996G>C	uc001oar.2	-	9	1717	c.1278C>G	c.(1276-1278)TTC>TTG	p.F426L	NRXN2_uc001oas.2_Missense_Mutation_p.F395L|NRXN2_uc001oaq.2_Missense_Mutation_p.F93L	NM_015080	NP_055895	P58401	NRX2B_HUMAN	neurexin 2 isoform alpha-1 precursor	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						CAATGTAGAAGAAGTCATCAG	0.612		NaN											0	0	0	0.008291	0	10	119									
SAPS3	55291	broad.mit.edu	37	11	68369379	68369379	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:68369379C>T	uc001onw.2	+	21	2508	c.2241C>T	c.(2239-2241)AGC>AGT	p.S747S	SAPS3_uc001onv.2_Silent_p.S747S|SAPS3_uc001ony.3_Silent_p.S718S|SAPS3_uc001onx.2_Silent_p.S741S|SAPS3_uc009ysh.2_Silent_p.S667S|SAPS3_uc001onu.2_Silent_p.S667S|SAPS3_uc010rqc.1_Silent_p.S515S|SAPS3_uc010rqd.1_Silent_p.S430S|SAPS3_uc001onz.2_Silent_p.S75S|SAPS3_uc001ooa.2_Silent_p.S197S	NM_001164161	NP_001157633	Q5H9R7	PP6R3_HUMAN	SAPS domain family, member 3 isoform 6	747					regulation of phosphoprotein phosphatase activity	cytoplasm|nucleus	protein phosphatase binding				0			LUAD - Lung adenocarcinoma(13;0.102)			TGGAAACCAGCACTGAACCCA	0.517		NaN											0	0	0	0.008871	0	16	136									
SAPS3	55291	broad.mit.edu	37	11	68377463	68377463	+	Silent	SNP	A	A	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:68377463A>C	uc001onw.2	+	23	2809	c.2542A>C	c.(2542-2544)AGG>CGG	p.R848R	SAPS3_uc001onv.2_Silent_p.R854R|SAPS3_uc001ony.3_Silent_p.R819R|SAPS3_uc001onx.2_Silent_p.R842R|SAPS3_uc009ysh.2_Silent_p.R768R|SAPS3_uc001onu.2_Silent_p.R768R|SAPS3_uc010rqc.1_Silent_p.R616R|SAPS3_uc010rqd.1_Silent_p.R531R|SAPS3_uc001onz.2_Silent_p.R176R|SAPS3_uc001ooa.2_Silent_p.R304R	NM_001164161	NP_001157633	Q5H9R7	PP6R3_HUMAN	SAPS domain family, member 3 isoform 6	848					regulation of phosphoprotein phosphatase activity	cytoplasm|nucleus	protein phosphatase binding				0			LUAD - Lung adenocarcinoma(13;0.102)			CGCGGCGCCCAGGCCTCCCAG	0.612		NaN											0	0	0	0.00308	0	7	40									
PPFIA1	8500	broad.mit.edu	37	11	70202353	70202353	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:70202353C>T	uc001opo.2	+	19	2773	c.2575C>T	c.(2575-2577)CAA>TAA	p.Q859*	PPFIA1_uc001opn.1_Nonsense_Mutation_p.Q859*|PPFIA1_uc001opp.2_RNA|PPFIA1_uc001opq.1_RNA	NM_003626	NP_003617	Q13136	LIPA1_HUMAN	PTPRF interacting protein alpha 1 isoform b	859	Potential.				cell-matrix adhesion	cytoplasm	protein binding|signal transducer activity			lung(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(2;1.04e-44)|LUSC - Lung squamous cell carcinoma(11;1.46e-14)|STAD - Stomach adenocarcinoma(18;0.0513)			TCGTAAACTTCAAAAAAAGTA	0.393		NaN											0	0	0	0.001168	0	5	82									
NADSYN1	55191	broad.mit.edu	37	11	71166203	71166203	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:71166203G>C	uc001oqn.2	+	2	259	c.133G>C	c.(133-135)GAG>CAG	p.E45Q	NADSYN1_uc001oqm.2_RNA|NADSYN1_uc001oqo.2_5'UTR	NM_018161	NP_060631	Q6IA69	NADE_HUMAN	NAD synthetase 1	45	CN hydrolase.				NAD biosynthetic process|water-soluble vitamin metabolic process	cytosol	ATP binding|hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds|NAD+ synthase (glutamine-hydrolyzing) activity|protein binding			ovary(2)	2					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	GCTTGGACCAGAGCTGGAAAT	0.473		NaN											0	0	0	0.004482	0	8	72									
PCF11	51585	broad.mit.edu	37	11	82877138	82877138	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:82877138G>C	uc001ozx.3	+	5	1544	c.1199G>C	c.(1198-1200)AGA>ACA	p.R400T	PCF11_uc010rsu.1_Missense_Mutation_p.R400T	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	400	Lys-rich.				mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						ATGAACAAGAGAGATCCAAGA	0.338		NaN											0	0	0	0.009096	0	3	16									
NOX4	50507	broad.mit.edu	37	11	89177304	89177304	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:89177304T>A	uc001pct.2	-	5	685	c.446A>T	c.(445-447)GAG>GTG	p.E149V	NOX4_uc009yvr.2_Missense_Mutation_p.E124V|NOX4_uc001pcu.2_Missense_Mutation_p.E75V|NOX4_uc001pcw.2_Intron|NOX4_uc001pcx.2_Intron|NOX4_uc001pcv.2_Missense_Mutation_p.E149V|NOX4_uc009yvo.2_RNA|NOX4_uc010rtu.1_Intron|NOX4_uc009yvp.2_Missense_Mutation_p.E149V|NOX4_uc010rtv.1_Missense_Mutation_p.E125V|NOX4_uc009yvq.2_Missense_Mutation_p.E125V|NOX4_uc009yvs.1_RNA	NM_016931	NP_058627	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4 isoform a	149	Extracellular (Potential).|Ferric oxidoreductase.				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				ACCACCCACCTCATCTCGGTA	0.448		NaN											0	0	0	0.00245	0	13	125									
NOX4	50507	broad.mit.edu	37	11	89223638	89223638	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:89223638G>C	uc001pct.2	-	2	380	c.141C>G	c.(139-141)CAC>CAG	p.H47Q	NOX4_uc009yvr.2_Intron|NOX4_uc001pcu.2_5'UTR|NOX4_uc001pcw.2_Missense_Mutation_p.H47Q|NOX4_uc001pcx.2_Missense_Mutation_p.H47Q|NOX4_uc001pcv.2_Missense_Mutation_p.H47Q|NOX4_uc009yvo.2_RNA|NOX4_uc010rtu.1_5'UTR|NOX4_uc009yvp.2_Missense_Mutation_p.H47Q|NOX4_uc010rtv.1_Missense_Mutation_p.H23Q|NOX4_uc009yvq.2_Missense_Mutation_p.H23Q|NOX4_uc009yvs.1_RNA|NOX4_uc001pcy.2_RNA	NM_016931	NP_058627	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4 isoform a	47	Extracellular (Potential).				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				CCAACATCTGGTGGAGGTAGT	0.438		NaN											0	0	0	0.00245	0	10	93									
ARHGAP20	57569	broad.mit.edu	37	11	110451669	110451669	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:110451669C>T	uc001pkz.1	-	16	2286	c.2001G>A	c.(1999-2001)AAG>AAA	p.K667K	ARHGAP20_uc001pky.1_Silent_p.K644K|ARHGAP20_uc009yyb.1_Silent_p.K631K|ARHGAP20_uc001pla.1_Silent_p.K631K|ARHGAP20_uc001plb.2_Silent_p.K210K	NM_020809	NP_065860	Q9P2F6	RHG20_HUMAN	Rho GTPase activating protein 20	667					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(3)|kidney(2)	5		all_cancers(61;3.26e-12)|all_epithelial(67;6.09e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;0.000484)|Acute lymphoblastic leukemia(157;0.000967)|all_neural(223;0.0199)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;3.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.24e-05)|all cancers(92;0.000147)|OV - Ovarian serous cystadenocarcinoma(223;0.0475)		GCAGTGGGATCTTTGTGTACA	0.507		NaN											0	0	0	0.001168	0	3	46									
BTG4	54766	broad.mit.edu	37	11	111367977	111367977	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:111367977G>A	uc001plj.2	-	4	654	c.469C>T	c.(469-471)CGT>TGT	p.R157C	BTG4_uc001plk.2_Missense_Mutation_p.R157C	NM_017589	NP_060059	Q9NY30	BTG4_HUMAN	B-cell translocation gene 4	157					cell cycle arrest|negative regulation of cell proliferation|neuron differentiation						0		all_cancers(61;3.78e-13)|all_epithelial(67;5.29e-08)|Melanoma(852;3.15e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0204)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;1.22e-06)|BRCA - Breast invasive adenocarcinoma(274;1.72e-06)|all cancers(92;2.18e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0509)		GGAATGACACGAGGTTCCTTG	0.388		NaN											0	0	0	0.001984	0	5	125									
CLDN25	644672	broad.mit.edu	37	11	113650727	113650727	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:113650727C>G	uc009yyw.1	+	1	210	c.210C>G	c.(208-210)TTC>TTG	p.F70L		NM_001101389	NP_001094859	C9JDP6	CLD25_HUMAN	claudin 25	70	Extracellular (Potential).					integral to membrane|tight junction	structural molecule activity				0						TTGAATCCTTCTTGTCTCTGC	0.562		NaN											0	0	0	0.00308	0	8	90									
SIDT2	51092	broad.mit.edu	37	11	117066606	117066606	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:117066606C>A	uc001pqh.1	+	25	2452	c.2411C>A	c.(2410-2412)TCC>TAC	p.S804Y	SIDT2_uc010rxe.1_Missense_Mutation_p.S804Y|SIDT2_uc001pqg.2_Missense_Mutation_p.S825Y|SIDT2_uc001pqi.1_Missense_Mutation_p.S801Y|SIDT2_uc001pqj.1_Missense_Mutation_p.S116Y|uc001pqk.1_RNA	NM_001040455	NP_001035545	Q8NBJ9	SIDT2_HUMAN	SID1 transmembrane family, member 2 precursor	804	Helical; (Potential).					integral to membrane|lysosomal membrane					0	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000219)|all cancers(92;0.00144)		TTCCTCTCCTCCATCGCCATG	0.612		NaN											1	0	8.34094e-07	0.008871	8.96875e-07	17	236									
USP2	9099	broad.mit.edu	37	11	119228516	119228516	+	Silent	SNP	C	C	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:119228516C>A	uc001pwm.3	-	10	1747	c.1452G>T	c.(1450-1452)CGG>CGT	p.R484R	USP2_uc001pwl.3_Silent_p.R275R|USP2_uc001pwn.3_Silent_p.R241R	NM_004205	NP_004196	O75604	UBP2_HUMAN	ubiquitin specific peptidase 2 isoform a	484	Necessary for interaction with MDM4.				cell cycle|muscle organ development|negative regulation of transcription from RNA polymerase II promoter|positive regulation of mitotic cell cycle|protein deubiquitination|protein stabilization|ubiquitin-dependent protein catabolic process	nucleus|perinuclear region of cytoplasm	cyclin binding|cysteine-type endopeptidase activity|metal ion binding|ubiquitin protein ligase binding|ubiquitin thiolesterase activity			ovary(2)|urinary_tract(1)|skin(1)	4		all_hematologic(192;4.65e-05)|Breast(348;0.0101)|all_neural(223;0.0218)|Medulloblastoma(222;0.0425)|Renal(330;0.157)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.000513)|Colorectal(284;0.0116)|Lung(307;0.0853)|LUSC - Lung squamous cell carcinoma(976;0.0889)		TCTTTATACACCGTTTTCTGC	0.498		NaN											1	0	3.11337e-16	0.013726	3.43387e-16	30	309									
ARHGEF12	23365	broad.mit.edu	37	11	120298895	120298895	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:120298895C>G	uc001pxl.1	+	8	531	c.524C>G	c.(523-525)TCT>TGT	p.S175C	ARHGEF12_uc009zat.2_Missense_Mutation_p.S156C|ARHGEF12_uc010rzn.1_Missense_Mutation_p.S72C|ARHGEF12_uc009zau.1_Missense_Mutation_p.S72C	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	175					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		ATCATGACATCTCCTCATTCA	0.498		NaN	T	MLL	AML								0	0	0	0.014323	0	16	156									
UBASH3B	84959	broad.mit.edu	37	11	122647792	122647792	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr11:122647792C>T	uc001pyi.3	+	3	636	c.276C>T	c.(274-276)CTC>CTT	p.L92L		NM_032873	NP_116262	Q8TF42	UBS3B_HUMAN	ubiquitin associated and SH3 domain containing,	92						cytoplasm|nucleus	protein tyrosine phosphatase activity			central_nervous_system(1)	1		Breast(109;0.00254)|Medulloblastoma(222;0.00877)|Lung NSC(97;0.0183)|all_lung(97;0.0186)|all_neural(223;0.0381)|all_hematologic(192;0.104)		BRCA - Breast invasive adenocarcinoma(274;1.37e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0463)		AGTACGTCCTCTACCTCCGTC	0.562		NaN											0	0	0	0.00308	0	8	65									
IQSEC3	440073	broad.mit.edu	37	12	275008	275008	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:275008A>G	uc001qhw.1	+	8	2020	c.2014A>G	c.(2014-2016)AAG>GAG	p.K672E	IQSEC3_uc001qhu.1_Missense_Mutation_p.K672E	NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	975	Potential.|PH.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		GGAGGACCTGAAGGAGTCCAT	0.602		NaN											0	0	0	0.00245	0	11	36									
WNK1	65125	broad.mit.edu	37	12	989996	989996	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:989996C>T	uc001qio.3	+	12	3449	c.2942C>T	c.(2941-2943)CCG>CTG	p.P981L	WNK1_uc001qip.3_Intron|WNK1_uc001qir.3_Intron	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	981					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			CCTCCCATGCCGACAGAAGTA	0.502		NaN											0	0	0	0.001168	0	5	321									
SCNN1A	6337	broad.mit.edu	37	12	6458367	6458367	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:6458367G>A	uc001qnx.2	-	10	1749	c.1460C>T	c.(1459-1461)TCT>TTT	p.S487F	SCNN1A_uc001qnv.2_Missense_Mutation_p.S187F|SCNN1A_uc001qnw.2_Missense_Mutation_p.S546F|SCNN1A_uc010sfb.1_Missense_Mutation_p.S510F	NM_001038	NP_001029	P37088	SCNNA_HUMAN	sodium channel, nonvoltage-gated 1 alpha isoform	487	Extracellular (By similarity).				excretion|response to stimulus|sensory perception of taste	apical plasma membrane	WW domain binding				0					Amiloride(DB00594)|Triamterene(DB00384)	GTAACCAGCAGAGAGCTGGTA	0.572		NaN											0	0	0	0.00499	0	15	164									
ATN1	1822	broad.mit.edu	37	12	7044738	7044738	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:7044738C>G	uc001qrw.1	+	5	545	c.308C>G	c.(307-309)TCC>TGC	p.S103C	ATN1_uc001qrx.1_Missense_Mutation_p.S103C|ATN1_uc001qry.1_Missense_Mutation_p.S102C	NM_001007026	NP_001007027	P54259	ATN1_HUMAN	atrophin-1	103					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						CAGTCTCCCTCCGATCTGGAT	0.532		NaN											0	0	0	0.008291	0	10	30									
RECQL	5965	broad.mit.edu	37	12	21624538	21624538	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:21624538G>A	uc001rex.2	-	14	1839	c.1491C>T	c.(1489-1491)ATC>ATT	p.I497I	RECQL_uc001rey.2_Silent_p.I497I	NM_032941	NP_116559	P46063	RECQ1_HUMAN	RecQ protein-like	497					DNA recombination|DNA repair|DNA replication	nucleus	ATP binding|ATP-dependent 3'-5' DNA helicase activity|DNA strand annealing activity|protein binding			ovary(1)|lung(1)	2						TCAGGATCTTGATTAGATCTC	0.383		NaN						Direct_reversal_of_damage|Other_identified_genes_with_known_or_suspected_DNA_repair_function					0	0	0	0.001984	0	5	89									
ABCC9	10060	broad.mit.edu	37	12	21995253	21995253	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:21995253G>A	uc001rfi.1	-	27	3488	c.3468C>T	c.(3466-3468)GCC>GCT	p.A1156A	ABCC9_uc001rfh.2_Silent_p.A1156A|ABCC9_uc001rfj.1_Silent_p.A1120A	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	1156	Extracellular (Potential).|ABC transmembrane type-1 2.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	CTTACTTAGAGGCAACCCGAA	0.308		NaN											0	0	0	0.013537	0	10	25									
KIAA0528	9847	broad.mit.edu	37	12	22627716	22627716	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:22627716G>C	uc001rfq.2	-	16	2240	c.2012C>G	c.(2011-2013)TCA>TGA	p.S671*	KIAA0528_uc010sir.1_Nonsense_Mutation_p.S486*|KIAA0528_uc010sis.1_Nonsense_Mutation_p.S671*|KIAA0528_uc010sit.1_Nonsense_Mutation_p.S673*|KIAA0528_uc010siu.1_Nonsense_Mutation_p.S671*|KIAA0528_uc001rfr.2_Nonsense_Mutation_p.S662*	NM_014802	NP_055617	Q86YS7	K0528_HUMAN	hypothetical protein LOC9847	671							protein binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						TTTCCCATGTGAAAGGTCTAA	0.383		NaN											0	0	0	0.010729	0	9	98									
TMTC1	83857	broad.mit.edu	37	12	29736357	29736357	+	Silent	SNP	T	T	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:29736357T>A	uc001rjb.2	-	8	1551	c.1077A>T	c.(1075-1077)TCA>TCT	p.S359S	TMTC1_uc001riz.2_Silent_p.S116S|TMTC1_uc001rja.2_Silent_p.S203S|TMTC1_uc001rjc.1_Silent_p.S421S	NM_175861	NP_787057	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat	467						integral to membrane	binding				0	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					GGGACTCTCTTGACAGCCAAA	0.398		NaN											0	0	0	0.001168	0	4	55									
PKP2	5318	broad.mit.edu	37	12	32974300	32974300	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:32974300C>T	uc001rlj.3	-	10	2250	c.2135G>A	c.(2134-2136)GGA>GAA	p.G712E	PKP2_uc001rlk.3_Missense_Mutation_p.G668E|PKP2_uc010skj.1_Missense_Mutation_p.G665E	NM_004572	NP_004563	Q99959	PKP2_HUMAN	plakophilin 2 isoform 2b	712					cell-cell adhesion	desmosome|integral to membrane|nucleus	binding			ovary(1)|pancreas(1)	2	Lung NSC(5;9.35e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)					TGGTCCACTTCCGGCCGTGAG	0.423		NaN											0	0	0	0.004482	0	7	40									
TMEM106C	79022	broad.mit.edu	37	12	48361983	48361983	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:48361983G>T	uc001rqp.2	+	8	839	c.724G>T	c.(724-726)GAT>TAT	p.D242Y	TMEM106C_uc001rqo.2_Missense_Mutation_p.D223Y|TMEM106C_uc001rqr.2_Missense_Mutation_p.D242Y|TMEM106C_uc001rqq.2_Missense_Mutation_p.D223Y	NM_024056	NP_076961	Q9BVX2	T106C_HUMAN	transmembrane protein 106C isoform a	242						endoplasmic reticulum membrane|integral to membrane					0		Acute lymphoblastic leukemia(13;0.11)		GBM - Glioblastoma multiforme(48;0.241)		TCACTATGTGGATTGTGGAGG	0.428		NaN											1	0	4.36969e-10	0.001855	4.76694e-10	10	70									
ADCY6	112	broad.mit.edu	37	12	49177157	49177157	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:49177157C>T	uc001rsh.3	-	1	721	c.61G>A	c.(61-63)GAA>AAA	p.E21K	ADCY6_uc001rsj.3_Missense_Mutation_p.E21K|ADCY6_uc001rsi.3_Missense_Mutation_p.E21K	NM_015270	NP_056085	O43306	ADCY6_HUMAN	adenylate cyclase 6 isoform a	21	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding				0						CCATTGCGTTCACCCCAGGCT	0.582		NaN											0	0	0	0.001168	0	6	36									
MLL2	8085	broad.mit.edu	37	12	49444684	49444684	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:49444684G>A	uc001rta.3	-	10	2782	c.2782C>T	c.(2782-2784)CAG>TAG	p.Q928*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	928	Pro-rich.			Missing (in Ref. 1; AAC51734).	chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						GGCATCAGCTGAGGCGACAAG	0.547		NaN	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			0	0	0	0.004007	0	12	71									
TFCP2	7024	broad.mit.edu	37	12	51512521	51512521	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:51512521C>T	uc001rxw.2	-	2	616	c.157G>A	c.(157-159)GAG>AAG	p.E53K	TFCP2_uc001rxv.1_Missense_Mutation_p.E53K|TFCP2_uc009zlx.1_Missense_Mutation_p.E53K|TFCP2_uc001rxx.2_Missense_Mutation_p.E53K|TFCP2_uc009zly.1_5'UTR	NM_005653	NP_005644	Q12800	TFCP2_HUMAN	transcription factor CP2	53					regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						AAACTCGACTCTTCTTGCTTA	0.398		NaN											0	0	0	0.001168	0	6	115									
MFSD5	84975	broad.mit.edu	37	12	53647579	53647579	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:53647579C>T	uc001sci.1	+	2	1151	c.960C>T	c.(958-960)CTC>CTT	p.L320L	MFSD5_uc001sch.1_Silent_p.L427L	NM_032889	NP_116278	Q6N075	MFSD5_HUMAN	major facilitator superfamily domain containing	320	Helical; (Potential).				transport	integral to membrane				skin(2)|ovary(1)	3						TTGCTGTGCTCATCGTCGTCT	0.547		NaN											0	0	0	0.001984	0	6	75									
HOXC4	3221	broad.mit.edu	37	12	54447857	54447857	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:54447857G>A	uc001seu.2	+	3	831	c.151G>A	c.(151-153)GAG>AAG	p.E51K	HOXC4_uc001sex.2_Missense_Mutation_p.E51K	NM_014620	NP_055435	P09017	HXC4_HUMAN	homeobox C4	51						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TCACCACCAGGAGCTGTACCC	0.607		NaN											0	0	0	0.00499	0	16	213									
OR6C76	390326	broad.mit.edu	37	12	55820661	55820661	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:55820661G>C	uc010spm.1	+	1	624	c.624G>C	c.(622-624)TTG>TTC	p.L208F		NM_001005183	NP_001005183	A6NM76	O6C76_HUMAN	olfactory receptor, family 6, subfamily C,	208	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TATCCACTTTGATATTAGTAA	0.398		NaN											0	0	0	0.000602	0	5	25									
DNAJC14	85406	broad.mit.edu	37	12	56215782	56215782	+	Silent	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:56215782C>G	uc001shx.1	-	7	2292	c.2088G>C	c.(2086-2088)GTG>GTC	p.V696V	DNAJC14_uc001shu.1_Intron|DNAJC14_uc009zob.1_Silent_p.V696V	NM_032364	NP_115740	Q6Y2X3	DJC14_HUMAN	dopamine receptor interacting protein	696					protein folding|protein transport	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|unfolded protein binding			ovary(3)|large_intestine(1)	4						AGGGCCTCCTCACTTTCTTCC	0.542		NaN											0	0	0	0.007413	0	14	128									
TIMELESS	8914	broad.mit.edu	37	12	56822054	56822054	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:56822054C>T	uc001slf.2	-	13	1712	c.1544G>A	c.(1543-1545)CGA>CAA	p.R515Q	TIMELESS_uc001slg.2_Missense_Mutation_p.R514Q	NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	515					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						CCGACAGAATCGCTCCAACAT	0.542		NaN											0	0	0	0.007413	0	13	58									
TIMELESS	8914	broad.mit.edu	37	12	56822689	56822689	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:56822689C>T	uc001slf.2	-	11	1450	c.1282G>A	c.(1282-1284)GAA>AAA	p.E428K	TIMELESS_uc001slg.2_Missense_Mutation_p.E427K	NM_003920	NP_003911	Q9UNS1	TIM_HUMAN	timeless homolog	428					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				ovary(5)|breast(2)|pancreas(1)	8						GAGGCAGCTTCCTTGCGGTCA	0.532		NaN											0	0	0	0.00499	0	12	38									
ZFC3H1	196441	broad.mit.edu	37	12	72022749	72022749	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:72022749C>G	uc001swo.2	-	20	4254	c.3895G>C	c.(3895-3897)GAT>CAT	p.D1299H		NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	1299					RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						AAGCTATTATCTGAAATAGGT	0.328		NaN											0	0	0	0.004672	0	3	42									
ZFC3H1	196441	broad.mit.edu	37	12	72057344	72057344	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:72057344G>A	uc001swo.2	-	1	406	c.47C>T	c.(46-48)CCG>CTG	p.P16L	ZFC3H1_uc010sts.1_Missense_Mutation_p.P16L|ZFC3H1_uc001swp.2_Missense_Mutation_p.P16L|THAP2_uc001swq.2_5'Flank	NM_144982	NP_659419	O60293	ZC3H1_HUMAN	proline/serine-rich coiled-coil 2	16					RNA processing	intracellular	metal ion binding			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5						TTCTTCCTTCGGCGAGAGGCC	0.652		NaN									OREG0021993	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.006122	0	13	181									
TMTC2	160335	broad.mit.edu	37	12	83455601	83455601	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:83455601G>A	uc001szt.2	+	11	2754	c.2322G>A	c.(2320-2322)CTG>CTA	p.L774L	TMTC2_uc010suk.1_Silent_p.L529L	NM_152588	NP_689801	Q8N394	TMTC2_HUMAN	transmembrane and tetratricopeptide repeat	774	TPR 9.					endoplasmic reticulum|integral to membrane	binding			ovary(2)	2						CAGCCAGGCTGAGGCCTAATG	0.353		NaN											0	0	0	0.001855	0	11	121									
TMTC3	160418	broad.mit.edu	37	12	88570051	88570051	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:88570051G>C	uc001tau.2	+	10	1607	c.1387G>C	c.(1387-1389)GAG>CAG	p.E463Q	TMTC3_uc009zsm.2_RNA	NM_181783	NP_861448	Q6ZXV5	TMTC3_HUMAN	transmembrane and tetratricopeptide repeat	463	TPR 2.					integral to membrane	binding			skin(1)	1						AAAGAACTTTGAGAGAGCTTT	0.289		NaN											0	0	0	0.000602	0	4	32									
NUDT4	11163	broad.mit.edu	37	12	93792607	93792607	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:93792607G>C	uc001tcm.2	+	4	714	c.316G>C	c.(316-318)GAT>CAT	p.D106H	NUDT4_uc010sup.1_Missense_Mutation_p.D106H|NUDT4_uc001tcn.2_Missense_Mutation_p.D54H|NUDT4_uc010suq.1_Missense_Mutation_p.D55H|NUDT4_uc001tco.2_Missense_Mutation_p.D54H	NM_019094	NP_061967	Q9NZJ9	NUDT4_HUMAN	nudix-type motif 4 isoform alpha	106	Nudix hydrolase.				calcium-mediated signaling|cyclic nucleotide metabolic process|cyclic-nucleotide-mediated signaling|intracellular transport|regulation of RNA export from nucleus	cytoplasm	diphosphoinositol-polyphosphate diphosphatase activity|metal ion binding				0						AATATTAGAAGATTGGGAAGA	0.323		NaN											0	0	0	0.004672	0	3	26									
TMCC3	57458	broad.mit.edu	37	12	94975783	94975783	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:94975783T>C	uc001tdj.2	-	2	728	c.610A>G	c.(610-612)AGA>GGA	p.R204G	TMCC3_uc001tdi.2_Missense_Mutation_p.R173G	NM_020698	NP_065749	Q9ULS5	TMCC3_HUMAN	transmembrane and coiled-coil domain family 3	204						integral to membrane				ovary(1)|skin(1)	2						GCAAACTCTCTGGACTTATTG	0.512		NaN											0	0	0	0.004007	0	13	82									
HAL	3034	broad.mit.edu	37	12	96389601	96389601	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:96389601C>T	uc001tem.1	-	2	385	c.88G>A	c.(88-90)GAG>AAG	p.E30K	HAL_uc009zti.1_RNA|HAL_uc010suw.1_5'UTR|HAL_uc010sux.1_Missense_Mutation_p.E30K	NM_002108	NP_002099	P42357	HUTH_HUMAN	histidine ammonia-lyase	30					biosynthetic process|histidine catabolic process	cytosol	histidine ammonia-lyase activity			ovary(2)|skin(1)	3					L-Histidine(DB00117)	CTCACGGCCTCCCGGCCCAGC	0.652		NaN											0	0	0	0.00308	0	7	33									
NEDD1	121441	broad.mit.edu	37	12	97345758	97345758	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:97345758C>G	uc001teu.3	+	16	2249	c.1910C>G	c.(1909-1911)TCA>TGA	p.S637*	NEDD1_uc001tev.3_Nonsense_Mutation_p.S637*|NEDD1_uc010svc.1_Nonsense_Mutation_p.S548*|NEDD1_uc001tew.2_Nonsense_Mutation_p.S644*|NEDD1_uc001tex.2_Nonsense_Mutation_p.S548*	NM_152905	NP_690869	Q8NHV4	NEDD1_HUMAN	neural precursor cell expressed, developmentally	637					cell division|G2/M transition of mitotic cell cycle|mitosis	cytosol					0						GAAAGATACTCAGTGAATGAA	0.318		NaN											0	0	0	0.001168	0	6	60									
ANKS1B	56899	broad.mit.edu	37	12	99640173	99640173	+	Silent	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:99640173G>C	uc001tge.1	-	13	2643	c.2226C>G	c.(2224-2226)CTC>CTG	p.L742L	ANKS1B_uc001tgf.1_Silent_p.L322L|ANKS1B_uc001tgk.2_Silent_p.L39L|ANKS1B_uc009ztt.1_Silent_p.L708L	NM_152788	NP_690001	Q7Z6G8	ANS1B_HUMAN	cajalin 2 isoform a	742						Cajal body|cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane					0		all_cancers(3;0.0197)|all_epithelial(3;0.0101)|Esophageal squamous(3;0.0559)|Breast(359;0.209)		OV - Ovarian serous cystadenocarcinoma(2;2.89e-08)|Epithelial(2;6.12e-08)|all cancers(2;4.07e-06)		GATAGGCAATGAGATCAGAAT	0.413		NaN											0	0	0	0.010729	0	11	45									
C12orf48	55010	broad.mit.edu	37	12	102547708	102547708	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:102547708C>G	uc001tjf.2	+	4	561	c.449C>G	c.(448-450)TCT>TGT	p.S150C	C12orf48_uc001tje.2_Missense_Mutation_p.S69C|C12orf48_uc001tjg.2_Missense_Mutation_p.S69C|C12orf48_uc010swa.1_Missense_Mutation_p.S227C|C12orf48_uc001tjh.2_Missense_Mutation_p.S69C|C12orf48_uc010swb.1_Intron|C12orf48_uc001tji.2_Missense_Mutation_p.S154C|C12orf48_uc009zuc.2_Intron|C12orf48_uc001tjj.2_5'UTR|C12orf48_uc001tjk.2_Missense_Mutation_p.S150C|C12orf48_uc009zud.2_Missense_Mutation_p.S150C	NM_017915	NP_060385	Q9NWS1	PR1BP_HUMAN	hypothetical protein LOC55010	150					response to DNA damage stimulus	cytoplasm|nucleus	DNA binding				0						ACTGATCTTTCTATACCAACA	0.338		NaN											0	0	0	0.003163	0	11	76									
NT5DC3	51559	broad.mit.edu	37	12	104182660	104182660	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:104182660A>T	uc010swe.1	-	10	1098	c.1057T>A	c.(1057-1059)TGG>AGG	p.W353R		NM_001031701	NP_001026871	Q86UY8	NT5D3_HUMAN	5'-nucleotidase domain containing 3	353							hydrolase activity|metal ion binding			ovary(2)|skin(1)	3						ATTTTATCCCAGAGTAAGACA	0.403		NaN											0	0	0	0.011902	0	35	196									
SLC41A2	84102	broad.mit.edu	37	12	105238268	105238268	+	Silent	SNP	T	T	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:105238268T>C	uc001tla.2	-	9	1685	c.1518A>G	c.(1516-1518)TTA>TTG	p.L506L		NM_032148	NP_115524	Q96JW4	S41A2_HUMAN	solute carrier family 41, member 2	506	Helical; (Potential).					integral to membrane|plasma membrane	magnesium ion transmembrane transporter activity			ovary(1)|skin(1)	2						CAGCGCCAAATAAATACACTA	0.318		NaN											0	0	0	0.00245	0	14	85									
CCDC64	92558	broad.mit.edu	37	12	120510439	120510439	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:120510439C>T	uc001txl.1	+	6	1239	c.1214C>T	c.(1213-1215)TCG>TTG	p.S405L	CCDC64_uc001txk.2_Missense_Mutation_p.S405L|CCDC64_uc009zwv.1_Intron|CCDC64_uc010sze.1_Intron|CCDC64_uc010szf.1_Missense_Mutation_p.S54L	NM_207311	NP_997194	Q6ZP65	BICR1_HUMAN	coiled-coil domain containing 64	405					Golgi to secretory granule transport|neuron projection development	centrosome	dynactin binding|Rab GTPase binding			ovary(2)	2	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TCAGAAACCTCGTCCGCCAAG	0.567		NaN											0	0	0	0.006214	0	8	62									
VPS37B	79720	broad.mit.edu	37	12	123380553	123380553	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:123380553G>C	uc001udl.2	-	1	160	c.57C>G	c.(55-57)AAC>AAG	p.N19K		NM_024667	NP_078943	Q9H9H4	VP37B_HUMAN	vacuolar protein sorting 37B	19					cellular membrane organization|endosome transport|protein transport	late endosome membrane					0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;5.08e-05)|Epithelial(86;0.000197)|BRCA - Breast invasive adenocarcinoma(302;0.205)		CCAGCAGCTCGTTGAGCTGCA	0.716		NaN											0	0	0	0.001168	0	3	47									
GPR133	283383	broad.mit.edu	37	12	131487836	131487836	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:131487836C>A	uc001uit.3	+	10	1692	c.1133C>A	c.(1132-1134)TCT>TAT	p.S378Y	GPR133_uc010tbm.1_Missense_Mutation_p.S410Y	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	378	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		GAGGGCTCCTCTGCCATGGCA	0.602		NaN											1	0	0.00116845	0.001168	0.00119841	4	44									
CHFR	55743	broad.mit.edu	37	12	133433091	133433092	+	Nonsense_Mutation	DNP	CC	CC	AA			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:133433091_133433092CC>AA	uc001ulf.2	-	10	1311_1312	c.1227_1228GG>TT	c.(1225-1230)CTGGAG>CTTTAG	p.E410*	CHFR_uc001ulc.1_RNA|CHFR_uc001ule.2_Nonsense_Mutation_p.E398*|CHFR_uc010tbs.1_Nonsense_Mutation_p.E410*|CHFR_uc001uld.2_Nonsense_Mutation_p.E369*|CHFR_uc010tbt.1_Nonsense_Mutation_p.E318*	NM_001161344	NP_001154816	Q96EP1	CHFR_HUMAN	checkpoint with forkhead and ring finger domains	410					cell division|mitosis|mitotic cell cycle checkpoint|modification-dependent protein catabolic process|protein polyubiquitination	PML body	nucleotide binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			skin(1)	1	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_cancers(7;0.00552)|all_epithelial(31;0.226)		OV - Ovarian serous cystadenocarcinoma(86;2.59e-08)|Epithelial(86;6.38e-07)|all cancers(50;1.56e-05)		TCTGACAGCTCCAGCAGGTCCT	0.505		NaN											0	0	0	0.004672	0	29	99									
CENPJ	55835	broad.mit.edu	37	13	25473722	25473722	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr13:25473722C>A	uc001upt.3	-	9	3079	c.2826G>T	c.(2824-2826)AGG>AGT	p.R942S	CENPJ_uc010tdf.1_RNA|CENPJ_uc010aae.2_RNA|CENPJ_uc010aaf.2_RNA|CENPJ_uc001upu.2_5'UTR	NM_018451	NP_060921	Q9HC77	CENPJ_HUMAN	centromere protein J	942					cell division|centriole replication|G2/M transition of mitotic cell cycle|microtubule nucleation|microtubule polymerization	centriole|cytosol|gamma-tubulin small complex|microtubule	protein domain specific binding|tubulin binding			ovary(2)	2		Lung SC(185;0.0225)|Breast(139;0.0602)		all cancers(112;0.00793)|Epithelial(112;0.0411)|OV - Ovarian serous cystadenocarcinoma(117;0.139)		CAATTTCTTTCCTAAAATGAC	0.403		NaN											1	0	0.000442599	0.006214	0.000456288	7	29									
CDK8	1024	broad.mit.edu	37	13	26828880	26828880	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr13:26828880C>T	uc001uqr.1	+	1	128	c.102C>T	c.(100-102)CAC>CAT	p.H34H	CDK8_uc001uqs.1_Silent_p.H34H|CDK8_uc001uqt.1_Translation_Start_Site	NM_001260	NP_001251	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	34	Protein kinase.|ATP (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|large_intestine(1)|ovary(1)|skin(1)	5	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		CTTATGGTCACGTCTACAAAG	0.607		NaN											0	0	0	0.00308	0	7	28									
FRY	10129	broad.mit.edu	37	13	32826017	32826017	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr13:32826017G>A	uc001utx.2	+	50	7669	c.7173G>A	c.(7171-7173)AAG>AAA	p.K2391K	FRY_uc010tdw.1_RNA|FRY_uc001uty.2_5'Flank	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	2391					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		TTTTCCAGAAGAGAACAAAAG	0.323		NaN											0	0	0	0.003163	0	10	139									
DIAPH3	81624	broad.mit.edu	37	13	60545102	60545102	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr13:60545102G>T	uc001vht.2	-	16	2062	c.1843C>A	c.(1843-1845)CCC>ACC	p.P615T	DIAPH3_uc001vhu.2_Missense_Mutation_p.P352T|DIAPH3_uc001vhv.2_Missense_Mutation_p.P193T	NM_001042517	NP_001035982	Q9NSV4	DIAP3_HUMAN	diaphanous homolog 3 isoform a	615	FH1.|Pro-rich.				actin cytoskeleton organization		actin binding|Rho GTPase binding			ovary(2)	2		Breast(118;0.052)|Prostate(109;0.103)|Hepatocellular(98;0.132)		GBM - Glioblastoma multiforme(99;2.77e-05)		AATCCCAGGGGAGGTGGTGGA	0.542		NaN											1	0	6.31075e-24	0.01441	6.98607e-24	40	113									
KLF5	688	broad.mit.edu	37	13	73636090	73636090	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr13:73636090C>T	uc001vje.2	+	2	677	c.353C>T	c.(352-354)TCA>TTA	p.S118L	KLF5_uc001vjd.2_Missense_Mutation_p.S27L	NM_001730	NP_001721	Q13887	KLF5_HUMAN	Kruppel-like factor 5	118					transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|pancreas(1)	3		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		GACAGTGCCTCAGTCGTAGAC	0.443		NaN											0	0	0	0.007413	0	17	243									
KLF5	688	broad.mit.edu	37	13	73636396	73636396	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr13:73636396C>T	uc001vje.2	+	2	983	c.659C>T	c.(658-660)TCT>TTT	p.S220F	KLF5_uc001vjd.2_Missense_Mutation_p.S129F	NM_001730	NP_001721	Q13887	KLF5_HUMAN	Kruppel-like factor 5	220					transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|pancreas(1)	3		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		CTTCATCTTTCTGTCCCTACC	0.463		NaN											0	0	0	0.009096	0	4	93									
LMO7	4008	broad.mit.edu	37	13	76335156	76335156	+	Translation_Start_Site	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr13:76335156C>G	uc001vjv.2	+	1	360	c.-400C>G	c.(-402--398)ATCAA>ATGAA		LMO7_uc010thv.1_Nonsense_Mutation_p.S152*|LMO7_uc001vjt.1_Nonsense_Mutation_p.S100*|LMO7_uc010thw.1_Nonsense_Mutation_p.S61*|LMO7_uc001vju.1_RNA	NM_015842	NP_056667	Q8WWI1	LMO7_HUMAN	LIM domain only 7 isoform 2							cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		CAGGATTTATCAAATCGAGTC	0.333		NaN											0	0	0	0.007413	0	15	34									
NALCN	259232	broad.mit.edu	37	13	102029397	102029397	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr13:102029397A>C	uc001vox.1	-	5	575	c.386T>G	c.(385-387)ATT>AGT	p.I129S	NALCN_uc001voy.2_5'UTR|NALCN_uc001voz.2_Missense_Mutation_p.I129S|NALCN_uc001vpa.2_Missense_Mutation_p.I129S	NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	129	Extracellular (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					TATATCAGCAATTTCAAACAC	0.403		NaN											0	0	0	0.000602	0	5	83									
MYO16	23026	broad.mit.edu	37	13	109661365	109661365	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr13:109661365A>G	uc001vqt.1	+	22	2623	c.2497A>G	c.(2497-2499)AAC>GAC	p.N833D	MYO16_uc010agk.1_Missense_Mutation_p.N855D|MYO16_uc001vqu.1_Missense_Mutation_p.N633D|MYO16_uc010tjh.1_Missense_Mutation_p.N345D	NM_015011	NP_055826	Q9Y6X6	MYO16_HUMAN	myosin heavy chain Myr 8	833					cerebellum development|negative regulation of cell proliferation|negative regulation of S phase of mitotic cell cycle	myosin complex|nucleoplasm|perinuclear region of cytoplasm|plasma membrane	actin filament binding|ATP binding|motor activity			ovary(6)|large_intestine(1)|kidney(1)|breast(1)|central_nervous_system(1)	10	all_lung(23;0.000332)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung NSC(43;0.00751)|Lung SC(71;0.104)		BRCA - Breast invasive adenocarcinoma(86;0.19)|all cancers(43;0.201)			TTCTCCTGGTAACCAGAATGG	0.353		NaN											0	0	0	0.013537	0	11	128									
TMCO3	55002	broad.mit.edu	37	13	114154315	114154315	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr13:114154315G>A	uc001vtu.3	+	4	1028	c.667G>A	c.(667-669)GAA>AAA	p.E223K	TMCO3_uc001vtt.3_Missense_Mutation_p.E223K	NM_017905	NP_060375	Q6UWJ1	TMCO3_HUMAN	transmembrane and coiled-coil domains 3	223	Poly-Glu.			E -> G (in Ref. 2; BAA91295).		integral to membrane	solute:hydrogen antiporter activity				0	Lung NSC(43;0.0161)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0145)|all_epithelial(44;0.00286)|all_lung(25;0.0273)|Breast(118;0.0411)|Lung NSC(25;0.0983)	all cancers(43;0.0317)			GGTGGAGGAAGAAGAGGCCAA	0.383		NaN											0	0	0	0.000602	0	4	68									
CHD8	57680	broad.mit.edu	37	14	21897300	21897300	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:21897300C>T	uc001was.1	-	3	295	c.201G>A	c.(199-201)CAG>CAA	p.Q67Q	CHD8_uc001war.1_5'UTR	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	346	Gln-rich.				ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		TTTGCTGTGGCTGCTGCACCT	0.567		NaN											0	0	0	0.006214	0	9	87									
MMP14	4323	broad.mit.edu	37	14	23306101	23306101	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:23306101C>T	uc001whc.2	+	1	309	c.75C>T	c.(73-75)CTC>CTT	p.L25L		NM_004995	NP_004986	P50281	MMP14_HUMAN	matrix metalloproteinase 14 preproprotein	25						extracellular matrix|integral to plasma membrane|melanosome	calcium ion binding|metalloendopeptidase activity|zinc ion binding				0	all_cancers(95;9.47e-05)			GBM - Glioblastoma multiforme(265;0.00551)		TCGCCTCCCTCGGCTCGGCCC	0.726		NaN									OREG0022586	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000602	0	5	47									
RNF31	55072	broad.mit.edu	37	14	24617902	24617902	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:24617902G>A	uc001wmn.1	+	4	796	c.547G>A	c.(547-549)GAA>AAA	p.E183K	PSME2_uc001wmj.2_5'Flank|PSME2_uc001wmk.2_5'Flank|RNF31_uc001wml.1_Missense_Mutation_p.E32K|RNF31_uc001wmm.1_Intron|RNF31_uc010alg.1_5'UTR|RNF31_uc001wmo.1_5'Flank|RNF31_uc001wmp.2_5'Flank	NM_017999	NP_060469	Q96EP0	RNF31_HUMAN	ring finger protein 31	183	Polyubiquitin-binding.				CD40 signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|protein linear polyubiquitination|T cell receptor signaling pathway	CD40 receptor complex|internal side of plasma membrane|LUBAC complex	ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(265;0.00861)		AGACAAGGTTGAAGATGATGT	0.453		NaN											0	0	0	0.001984	0	6	71									
HECTD1	25831	broad.mit.edu	37	14	31575931	31575931	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:31575931C>T	uc001wrc.1	-	38	7636	c.7147G>A	c.(7147-7149)GAG>AAG	p.E2383K	HECTD1_uc001wra.1_Missense_Mutation_p.E509K|HECTD1_uc001wrb.1_Missense_Mutation_p.E509K	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	2383	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		GTGTTCTTCTCATCTTCAGAA	0.378		NaN											0	0	0	0.00308	0	8	50									
HECTD1	25831	broad.mit.edu	37	14	31598386	31598386	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:31598386G>A	uc001wrc.1	-	25	4680	c.4191C>T	c.(4189-4191)ATC>ATT	p.I1397I	HECTD1_uc001wrb.1_5'UTR|HECTD1_uc001wrd.1_Silent_p.I865I	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	1397	Ser-rich.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		AACCCAAGCTGATGTCGCTGC	0.458		NaN											0	0	0	0.003163	0	12	183									
SOS2	6655	broad.mit.edu	37	14	50671004	50671004	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:50671004C>G	uc001wxs.3	-	2	309	c.211G>C	c.(211-213)GAG>CAG	p.E71Q	SOS2_uc010tql.1_Missense_Mutation_p.E71Q	NM_006939	NP_008870	Q07890	SOS2_HUMAN	son of sevenless homolog 2	71					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol	DNA binding|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(2)	2	all_epithelial(31;0.000822)|Breast(41;0.0065)					ATTTTTACCTCTACATCTTGA	0.313		NaN											0	0	0	0.012319	0	16	158									
PPP2R5E	5529	broad.mit.edu	37	14	63888788	63888788	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:63888788G>A	uc001xgd.1	-	4	969	c.379C>T	c.(379-381)CTC>TTC	p.L127F	PPP2R5E_uc010tsf.1_Missense_Mutation_p.L51F|PPP2R5E_uc010tsg.1_Missense_Mutation_p.L51F|PPP2R5E_uc001xge.2_Missense_Mutation_p.L127F|PPP2R5E_uc010tsh.1_Missense_Mutation_p.L127F|PPP2R5E_uc001xgf.1_RNA	NM_006246	NP_006237	Q16537	2A5E_HUMAN	epsilon isoform of regulatory subunit B56,	127					signal transduction	cytoplasm|intracellular membrane-bounded organelle|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(108;0.00197)|all cancers(60;0.0153)|BRCA - Breast invasive adenocarcinoma(234;0.128)		CTAGGAGGGAGAGTTCTGAAT	0.423		NaN											0	0	0	0.010729	0	8	72									
SYNE2	23224	broad.mit.edu	37	14	64457211	64457211	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:64457211C>G	uc001xgm.2	+	20	2626	c.2396C>G	c.(2395-2397)TCA>TGA	p.S799*	SYNE2_uc001xgl.2_Nonsense_Mutation_p.S799*	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	799	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CAAAATATTTCAAGCCAGGAG	0.353		NaN											0	0	0	0.004482	0	8	94									
SPTB	6710	broad.mit.edu	37	14	65220341	65220341	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:65220341C>T	uc001xhr.2	-	32	6570	c.6516G>A	c.(6514-6516)CCG>CCA	p.P2172P	SPTB_uc001xhs.2_Silent_p.P2172P|SPTB_uc010aqi.2_Silent_p.P833P	NM_001024858	NP_001020029	P11277	SPTB1_HUMAN	spectrin beta isoform a	Error:Variant_position_missing_in_P11277_after_alignment					actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		CATGGTCCCGCGGGGCCGGCA	0.627		NaN											0	0	0	0.004007	0	12	140									
FUT8	2530	broad.mit.edu	37	14	66208977	66208977	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:66208977G>C	uc001xin.2	+	11	2774	c.1577G>C	c.(1576-1578)GGA>GCA	p.G526A	FUT8_uc001xio.2_Missense_Mutation_p.G526A|FUT8_uc010tsp.1_Missense_Mutation_p.G363A|FUT8_uc001xir.3_RNA|FUT8_uc001xip.2_Missense_Mutation_p.G526A|FUT8_uc001xiq.2_Missense_Mutation_p.G397A|FUT8_uc001xis.2_Missense_Mutation_p.G120A	NM_178155	NP_835368	Q9BYC5	FUT8_HUMAN	fucosyltransferase 8 isoform a	526	SH3.|Lumenal (Potential).				in utero embryonic development|L-fucose catabolic process|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein glycosylation in Golgi|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	glycoprotein 6-alpha-L-fucosyltransferase activity|SH3 domain binding			ovary(1)	1				all cancers(60;0.00109)|OV - Ovarian serous cystadenocarcinoma(108;0.00242)|BRCA - Breast invasive adenocarcinoma(234;0.0114)		ATGGAACCTGGAGATATCATT	0.453		NaN											0	0	0	0.006122	0	13	128									
TTC9	23508	broad.mit.edu	37	14	71137851	71137851	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:71137851G>A	uc001xmi.2	+	3	991	c.648G>A	c.(646-648)CAG>CAA	p.Q216Q		NM_015351	NP_056166	Q92623	TTC9A_HUMAN	tetratricopeptide repeat domain 9	216							binding				0				all cancers(60;0.00545)|BRCA - Breast invasive adenocarcinoma(234;0.00747)|OV - Ovarian serous cystadenocarcinoma(108;0.0538)		GATGCTCCCAGAGAGAAAAAG	0.567		NaN											0	0	0	0.00308	0	6	37									
NRXN3	9369	broad.mit.edu	37	14	79270147	79270147	+	Silent	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:79270147C>G	uc001xun.2	+	6	1601	c.1110C>G	c.(1108-1110)GTC>GTG	p.V370V	NRXN3_uc001xum.1_RNA|NRXN3_uc010asv.1_Silent_p.V504V	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	743	Laminin G-like 4.|Extracellular (Potential).				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		GGGGGCGTGTCAAGCTCATGG	0.522		NaN											0	0	0	0.000602	0	5	42									
TSHR	7253	broad.mit.edu	37	14	81609311	81609311	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:81609311G>C	uc001xvd.1	+	10	1065	c.909G>C	c.(907-909)GAG>GAC	p.E303D		NM_000369	NP_000360	P16473	TSHR_HUMAN	thyroid stimulating hormone receptor isoform 1	303	Extracellular (Potential).				cell-cell signaling|positive regulation of cell proliferation	integral to plasma membrane	protein binding|thyroid-stimulating hormone receptor activity			thyroid(289)|ovary(5)|lung(3)|kidney(1)|skin(1)	299				BRCA - Breast invasive adenocarcinoma(234;0.0402)	Thyrotropin Alfa(DB00024)	TGTGTAATGAGAGCAGTATGC	0.343		NaN	Mis		toxic thyroid adenoma	thyroid  adenoma	Hereditary nonautoimmune hyperthyroidism; subclinical hypothyroidism 						0	0	0	0.004482	0	6	92									
STON2	85439	broad.mit.edu	37	14	81744768	81744768	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:81744768G>A	uc010tvu.1	-	4	1088	c.887C>T	c.(886-888)TCT>TTT	p.S296F	STON2_uc001xvk.1_Missense_Mutation_p.S296F|STON2_uc010tvt.1_Missense_Mutation_p.S93F	NM_033104	NP_149095	Q8WXE9	STON2_HUMAN	stonin 2	296					endocytosis|intracellular protein transport|regulation of endocytosis	clathrin adaptor complex|nucleolus	protein binding			skin(3)|pancreas(2)	5				BRCA - Breast invasive adenocarcinoma(234;0.0348)		GCGGTTTAAAGAGGAAATATC	0.468		NaN											0	0	0	0.00308	0	7	97									
SERPINA6	866	broad.mit.edu	37	14	94780794	94780794	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:94780794G>A	uc001ycv.2	-	2	296	c.192C>T	c.(190-192)TTC>TTT	p.F64F	SERPINA6_uc010auv.2_RNA	NM_001756	NP_001747	P08185	CBG_HUMAN	corticosteroid binding globulin precursor	64					regulation of proteolysis|transport	extracellular space	serine-type endopeptidase inhibitor activity|steroid binding			skin(3)|ovary(1)|central_nervous_system(1)	5		all_cancers(154;0.0482)|all_epithelial(191;0.166)		COAD - Colon adenocarcinoma(157;0.211)	Alclometasone(DB00240)|Beclomethasone(DB00394)|Ciclesonide(DB01410)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Halobetasol Propionate(DB00596)|Medrysone(DB00253)|Mitotane(DB00648)|Paramethasone(DB01384)|Prednisolone(DB00860)|Rimexolone(DB00896)|Triamcinolone(DB00620)	CAGGGGAGATGAAAATGTTCT	0.552		NaN											0	0	0	0.004482	0	7	44									
SERPINA3	12	broad.mit.edu	37	14	95080900	95080900	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:95080900G>A	uc001ydp.2	+	2	201	c.122G>A	c.(121-123)CGA>CAA	p.R41Q	SERPINA3_uc001ydo.3_Missense_Mutation_p.R66Q|SERPINA3_uc010avf.1_RNA|SERPINA3_uc001ydr.2_RNA|SERPINA3_uc001ydq.2_Missense_Mutation_p.R41Q|SERPINA3_uc001yds.2_Missense_Mutation_p.R41Q|SERPINA3_uc010avg.2_Missense_Mutation_p.R41Q	NM_001085	NP_001076	P01011	AACT_HUMAN	serpin peptidase inhibitor, clade A, member 3	41					acute-phase response|maintenance of gastrointestinal epithelium|regulation of lipid metabolic process|regulation of proteolysis	extracellular region|nucleus	DNA binding|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|central_nervous_system(2)|large_intestine(1)|skin(1)	6		all_cancers(154;0.0525)|all_epithelial(191;0.179)		COAD - Colon adenocarcinoma(157;0.212)|Epithelial(152;0.228)		AACCAAGACCGAGGGACACAC	0.582		NaN											0	0	0	0.004007	0	13	123									
AK7	122481	broad.mit.edu	37	14	96912869	96912869	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:96912869C>T	uc001yfn.2	+	8	839	c.795C>T	c.(793-795)GTC>GTT	p.V265V		NM_152327	NP_689540	Q96M32	KAD7_HUMAN	adenylate kinase 7	265	Potential.				cell projection organization	cytosol	adenylate kinase activity|ATP binding|cytidylate kinase activity			ovary(1)	1		all_cancers(154;0.0482)|all_epithelial(191;0.128)|Melanoma(154;0.155)		Epithelial(152;0.134)|COAD - Colon adenocarcinoma(157;0.228)		TACAAAACGTCATAGATCACG	0.443		NaN											0	0	0	0.00308	0	5	70									
C14orf68	283600	broad.mit.edu	37	14	100795964	100795964	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:100795964C>T	uc001yhc.2	+	6	982	c.909C>T	c.(907-909)GCC>GCT	p.A303A	C14orf68_uc001yhd.2_Silent_p.A157A	NM_207117	NP_997000	Q6Q0C1	S2547_HUMAN	chromosome 14 open reading frame 68	303					transmembrane transport	integral to membrane|mitochondrial inner membrane	binding				0		Melanoma(154;0.152)				TGAGGCTCGCCCGGGGTCTGC	0.652		NaN											0	0	0	0.007291	0	24	110									
DYNC1H1	1778	broad.mit.edu	37	14	102516520	102516520	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:102516520G>C	uc001yks.2	+	77	13961	c.13797G>C	c.(13795-13797)GAG>GAC	p.E4599D		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	4599					cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						CAAACACCGAGAAGAAGGCCA	0.592		NaN											0	0	0	0.001168	0	5	62									
CYFIP1	23191	broad.mit.edu	37	15	22929848	22929848	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr15:22929848G>A	uc001yus.2	+	6	626	c.522G>A	c.(520-522)CTG>CTA	p.L174L	CYFIP1_uc001yut.2_Silent_p.L174L|CYFIP1_uc010aya.1_Silent_p.L202L	NM_014608	NP_055423	Q7L576	CYFP1_HUMAN	cytoplasmic FMR1 interacting protein 1 isoform	174					axon extension|lamellipodium assembly|regulation of cell shape|ruffle organization	cell junction|lamellipodium|mRNA cap binding complex|perinuclear region of cytoplasm|ruffle|synapse|synaptosome	actin filament binding|Rac GTPase binding			ovary(4)|pancreas(3)|liver(1)|skin(1)	9		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.22e-06)|Epithelial(43;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00101)		TGGACGAGCTGAAGAACATGA	0.582		NaN											0	0	0	0.006214	0	7	54									
UBE3A	7337	broad.mit.edu	37	15	25601128	25601128	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr15:25601128T>C	uc001zaq.2	-	7	2044	c.2044A>G	c.(2044-2046)ATA>GTA	p.I682V	uc001zae.2_Intron|UBE3A_uc001zar.2_Missense_Mutation_p.I659V|UBE3A_uc001zas.2_Missense_Mutation_p.I679V|UBE3A_uc001zat.2_Missense_Mutation_p.I659V	NM_000462	NP_000453	Q05086	UBE3A_HUMAN	ubiquitin protein ligase E3A isoform 2	682					brain development|interspecies interaction between organisms|protein K48-linked ubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus|proteasome complex	protein binding|ubiquitin-protein ligase activity			upper_aerodigestive_tract(1)|ovary(1)|breast(1)	3		all_cancers(20;3.47e-21)|Breast(32;0.00123)		all cancers(64;2.78e-08)|Epithelial(43;8.85e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0155)|Lung(196;0.0616)		GTCTGTGATATCTGGAAAGTG	0.323		NaN											0	0	0	0.00308	0	7	137									
RYR3	6263	broad.mit.edu	37	15	34015011	34015011	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr15:34015011G>A	uc001zhi.2	+	44	6785	c.6715G>A	c.(6715-6717)GGG>AGG	p.G2239R	RYR3_uc010bar.2_Missense_Mutation_p.G2239R	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2239	4 X approximate repeats.|Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GGGGGGAAACGGGCTCTTGGC	0.572		NaN											0	0	0	0.00333	0	23	117									
PLCB2	5330	broad.mit.edu	37	15	40586548	40586548	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr15:40586548G>A	uc001zld.2	-	19	2281	c.1980C>T	c.(1978-1980)TTC>TTT	p.F660F	PLCB2_uc010bbo.2_Silent_p.F656F|PLCB2_uc010ucm.1_Silent_p.F660F	NM_004573	NP_004564	Q00722	PLCB2_HUMAN	phospholipase C, beta 2	660	PI-PLC Y-box.				activation of phospholipase C activity|intracellular signal transduction|lipid catabolic process|phospholipid metabolic process|synaptic transmission	cytosol	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(3)|breast(3)|kidney(1)|pancreas(1)	8		all_cancers(109;9.35e-19)|all_epithelial(112;1.18e-15)|Lung NSC(122;2.45e-11)|all_lung(180;6.47e-10)|Melanoma(134;0.0574)|Ovarian(310;0.0822)|Colorectal(260;0.117)		GBM - Glioblastoma multiforme(113;9.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0508)		GCCGGCGCATGAACTCATGCT	0.592		NaN											0	0	0	0.008871	0	18	50									
INO80	54617	broad.mit.edu	37	15	41313219	41313219	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr15:41313219C>T	uc001zni.2	-	26	3366	c.3153G>A	c.(3151-3153)TTG>TTA	p.L1051L	INO80_uc010ucu.1_RNA	NM_017553	NP_060023	Q9ULG1	INO80_HUMAN	INO80 complex homolog 1	1051	Assembles INO80 complex module consisting of conserved components INO80B, INO80C, ACTR5, RVBL1, RVBL2.				cell division|cellular response to ionizing radiation|cellular response to UV|chromatin remodeling|double-strand break repair via homologous recombination|mitotic sister chromatid segregation|positive regulation of cell growth|positive regulation of DNA replication involved in S phase|positive regulation of transcription from RNA polymerase II promoter|regulation of G1/S transition of mitotic cell cycle|spindle assembly|UV-damage excision repair	Ino80 complex|microtubule	actin binding|alpha-tubulin binding|ATP binding|ATPase activity|DNA binding|DNA helicase activity			ovary(2)|pancreas(1)|skin(1)	4						GGGCCCCATTCAACAAACACT	0.527		NaN											0	0	0	0.001855	0	10	57									
JMJD7-PLA2G4B	8681	broad.mit.edu	37	15	42134022	42134022	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr15:42134022G>A	uc010bco.2	+	8	597	c.496G>A	c.(496-498)GAG>AAG	p.E166K	JMJD7-PLA2G4B_uc001zoo.3_Missense_Mutation_p.E397K|JMJD7-PLA2G4B_uc010bcn.2_Missense_Mutation_p.E397K|JMJD7-PLA2G4B_uc001zoq.3_5'UTR|JMJD7-PLA2G4B_uc001zor.1_5'Flank	NM_001114633	NP_001108105	P0C869	PA24B_HUMAN	phospholipase A2, group IVB	166					arachidonic acid metabolic process|calcium-mediated signaling|glycerophospholipid catabolic process|inflammatory response|parturition	cytosol|early endosome membrane|extracellular region|mitochondrial membrane	calcium ion binding|calcium-dependent phospholipase A2 activity|calcium-dependent phospholipid binding|lysophospholipase activity			large_intestine(1)	1						TCCAGCCTCAGAGCACAGAGT	0.637		NaN											0	0	0	0.001168	0	5	19									
SLTM	79811	broad.mit.edu	37	15	59179635	59179635	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr15:59179635C>T	uc002afp.2	-	18	2568	c.2480G>A	c.(2479-2481)AGA>AAA	p.R827K	SLTM_uc002afn.2_Missense_Mutation_p.R369K|SLTM_uc002afo.2_Missense_Mutation_p.R809K|SLTM_uc002afq.2_Missense_Mutation_p.R396K|SLTM_uc010bgd.2_Missense_Mutation_p.R396K	NM_024755	NP_079031	Q9NWH9	SLTM_HUMAN	modulator of estrogen induced transcription	827	Arg/Glu-rich.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleotide binding|RNA binding			ovary(1)	1						CTCATTTCTTCTGGAGTCACT	0.463		NaN											0	0	0	0.007413	0	17	71									
CORO2B	10391	broad.mit.edu	37	15	69003924	69003924	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr15:69003924T>C	uc002arj.3	+	5	556	c.527T>C	c.(526-528)ATT>ACT	p.I176T	CORO2B_uc010bic.2_Missense_Mutation_p.I171T|CORO2B_uc002ark.2_5'Flank	NM_006091	NP_006082	Q9UQ03	COR2B_HUMAN	coronin, actin binding protein, 2B	176	WD 2.				actin cytoskeleton organization	actin cytoskeleton|cytoplasm|membrane	actin filament binding			ovary(3)|skin(2)|large_intestine(1)	6						GTGAAGATGATTGACTGCCAC	0.592		NaN											0	0	0	0.00308	0	6	46									
GRAMD2	196996	broad.mit.edu	37	15	72455648	72455648	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr15:72455648C>T	uc002atq.2	-	10	939	c.915G>A	c.(913-915)CTG>CTA	p.L305L	GRAMD2_uc010bis.2_Silent_p.L305L|GRAMD2_uc010ukh.1_Silent_p.L99L	NM_001012642	NP_001012660	Q8IUY3	GRAM2_HUMAN	GRAM domain containing 2	305						integral to membrane					0						CCCAGAGCCTCAGCTCCCCAG	0.562		NaN											0	0	0	0.00308	0	6	53									
CSPG4	1464	broad.mit.edu	37	15	75968309	75968309	+	Missense_Mutation	SNP	G	G	A	rs139798032	byFrequency	TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr15:75968309G>A	uc002baw.2	-	10	6644	c.6551C>T	c.(6550-6552)ACG>ATG	p.T2184M		NM_001897	NP_001888	Q6UVK1	CSPG4_HUMAN	chondroitin sulfate proteoglycan 4 precursor	2184	Extracellular (Potential).|Cysteine-containing.|Neurite growth inhibition (By similarity).				angiogenesis|cell differentiation|intracellular signal transduction|positive regulation of peptidyl-tyrosine phosphorylation|tissue remodeling	apical plasma membrane|cell surface|integral to plasma membrane|intracellular|lamellipodium membrane	protein kinase binding|signal transducer activity			ovary(2)|pancreas(1)	3						CCCTGCTTCCGTCCGGGCGGC	0.687		NaN											0	0	0	0.004672	0	3	13									
IL16	3603	broad.mit.edu	37	15	81552159	81552159	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr15:81552159C>A	uc002bgh.3	+	3	735	c.359C>A	c.(358-360)GCA>GAA	p.A120E	IL16_uc002bgc.2_RNA|IL16_uc010blq.1_Missense_Mutation_p.A120E|IL16_uc002bge.3_RNA|IL16_uc010unp.1_Missense_Mutation_p.A162E|IL16_uc002bgg.2_Missense_Mutation_p.A120E	NM_172217	NP_757366	Q14005	IL16_HUMAN	interleukin 16 isoform 2	120					immune response|interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus|plasma membrane	cytokine activity	p.A120E(1)		ovary(2)|lung(1)|skin(1)	4						AAACTAGAAGCACAAAGTAGT	0.443		NaN											1	0	9.31168e-06	0.001855	9.87104e-06	11	53									
SOX8	30812	broad.mit.edu	37	16	1035195	1035195	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr16:1035195G>A	uc002ckn.2	+	3	1265	c.1150G>A	c.(1150-1152)GGC>AGC	p.G384S		NM_014587	NP_055402	P57073	SOX8_HUMAN	SRY (sex determining region Y)-box 8	384					adipose tissue development|enteric nervous system development|fat cell differentiation|in utero embryonic development|metanephric nephron tubule formation|morphogenesis of a branching epithelium|negative regulation of apoptosis|negative regulation of myoblast differentiation|negative regulation of transcription, DNA-dependent|neural crest cell migration|oligodendrocyte differentiation|osteoblast differentiation|peripheral nervous system development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of gliogenesis|positive regulation of osteoblast proliferation|positive regulation of transcription from RNA polymerase II promoter|regulation of hormone levels|renal vesicle induction|retinal rod cell differentiation|Sertoli cell development|signal transduction|spermatogenesis|ureter morphogenesis	cytoplasm|nucleus				central_nervous_system(1)|skin(1)	2		Hepatocellular(780;0.00308)				GGGCGACTATGGCGACCTGCA	0.617		NaN											0	0	0	0.000602	0	5	15									
UBE2I	7329	broad.mit.edu	37	16	1374763	1374763	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr16:1374763G>A	uc002clc.1	+	7	550	c.446G>A	c.(445-447)CGA>CAA	p.R149Q	UBE2I_uc002cld.1_Missense_Mutation_p.R149Q|UBE2I_uc002clf.1_Missense_Mutation_p.R149Q|UBE2I_uc002clg.1_Missense_Mutation_p.R149Q	NM_194261	NP_919237	P63279	UBC9_HUMAN	ubiquitin-conjugating enzyme E2I	149					cell division|chromosome segregation|interspecies interaction between organisms|mitosis|negative regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|protein sumoylation	cytoplasm|PML body|synaptonemal complex	ATP binding|enzyme binding|ubiquitin-protein ligase activity			breast(1)|skin(1)	2		Hepatocellular(780;0.00369)				AAAAGGGTCCGAGCACAAGCC	0.522		NaN											0	0	0	0.006214	0	9	59									
PKD1	5310	broad.mit.edu	37	16	2155953	2155953	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr16:2155953G>A	uc002cos.1	-	20	7985	c.7776C>T	c.(7774-7776)ACC>ACT	p.T2592T	PKD1_uc002cot.1_Silent_p.T2592T|PKD1_uc010bse.1_5'Flank	NM_001009944	NP_001009944	P98161	PKD1_HUMAN	polycystin 1 isoform 1 precursor	2592	Extracellular (Potential).|REJ.				calcium-independent cell-matrix adhesion|homophilic cell adhesion|neuropeptide signaling pathway	basolateral plasma membrane|integral to plasma membrane	protein domain specific binding|sugar binding			central_nervous_system(2)|skin(1)	3						GCACACTAGCGGTGAGCCCGT	0.662		NaN											0	0	0	0.001168	0	4	44									
CLEC16A	23274	broad.mit.edu	37	16	11145497	11145497	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr16:11145497G>T	uc002dao.2	+	18	2224	c.1994G>T	c.(1993-1995)CGG>CTG	p.R665L	CLEC16A_uc002dan.3_Missense_Mutation_p.R647L	NM_015226	NP_056041	Q2KHT3	CL16A_HUMAN	C-type lectin domain family 16, member A	665										ovary(1)|central_nervous_system(1)	2						AAGACCCGGCGGGTGAGTGAG	0.602		NaN											1	0	2.23348e-06	0.004007	2.3845e-06	13	54									
TXNDC11	51061	broad.mit.edu	37	16	11792094	11792094	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr16:11792094G>A	uc010buu.1	-	8	1137	c.1075C>T	c.(1075-1077)CGG>TGG	p.R359W	TXNDC11_uc002dbg.1_Missense_Mutation_p.R332W	NM_015914	NP_056998	Q6PKC3	TXD11_HUMAN	thioredoxin domain containing 11	359					cell redox homeostasis	endoplasmic reticulum membrane|integral to membrane					0						CCGTGTGGCCGCAGCCACCGA	0.527		NaN											0	0	0	0.009096	0	3	75									
KIAA0430	9665	broad.mit.edu	37	16	15706612	15706612	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr16:15706612C>G	uc002ddr.2	-	17	3469	c.3276G>C	c.(3274-3276)AAG>AAC	p.K1092N	KIAA0430_uc002ddq.2_Missense_Mutation_p.K926N|KIAA0430_uc010uzv.1_Missense_Mutation_p.K1088N|KIAA0430_uc010uzw.1_Missense_Mutation_p.K1091N	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	limkain b1	1091						peroxisome	nucleotide binding|RNA binding				0						CTACAGGACTCTTCGAACGCA	0.468		NaN											0	0	0	0.006122	0	14	137									
MYH11	4629	broad.mit.edu	37	16	15813524	15813524	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr16:15813524G>A	uc002ddy.2	-	35	5107	c.5000C>T	c.(4999-5001)TCC>TTC	p.S1667F	MYH11_uc002ddv.2_Missense_Mutation_p.S1674F|MYH11_uc002ddw.2_Missense_Mutation_p.S1667F|MYH11_uc002ddx.2_Missense_Mutation_p.S1674F|MYH11_uc010bvg.2_Missense_Mutation_p.S1499F|NDE1_uc010uzy.1_Intron|NDE1_uc002dds.2_Intron|MYH11_uc010bvh.2_Missense_Mutation_p.S373F|NDE1_uc002ddz.1_5'Flank	NM_002474	NP_002465	P35749	MYH11_HUMAN	smooth muscle myosin heavy chain 11 isoform	1667	Potential.				axon guidance|cardiac muscle fiber development|elastic fiber assembly|skeletal muscle myosin thick filament assembly|smooth muscle contraction	cytosol|melanosome|muscle myosin complex|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity|structural constituent of muscle			ovary(6)|skin(3)|lung(2)|breast(2)|upper_aerodigestive_tract(1)|pancreas(1)	15						CTCATCTCTGGAGGCACGGGC	0.507		NaN	T	CBFB	AML								0	0	0	0.013537	0	9	96									
TAOK2	9344	broad.mit.edu	37	16	30002499	30002499	+	Silent	SNP	G	G	A	rs138517482		TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr16:30002499G>A	uc002dvc.1	+	19	3543	c.2760G>A	c.(2758-2760)CTG>CTA	p.L920L	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron	NM_004783	NP_004774	Q9UL54	TAOK2_HUMAN	TAO kinase 2 isoform 1	809	Glu-rich.				actin cytoskeleton organization|activation of MAPKK activity|apoptosis|cell migration|focal adhesion assembly|positive regulation of JNK cascade|protein targeting to membrane|regulation of cell growth|regulation of cell shape|response to stress	cytoplasmic vesicle membrane|cytoskeleton|dendrite|integral to membrane|nucleolus	ATP binding|protein serine/threonine kinase activity			ovary(1)	1						GCATGGCTCTGGGGGGCATCC	0.677		NaN											0	0	0	0.00245	0	12	102									
HSD3B7	80270	broad.mit.edu	37	16	30998197	30998197	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr16:30998197C>T	uc002eaf.2	+	6	674	c.568C>T	c.(568-570)CGT>TGT	p.R190C	HSD3B7_uc010cac.2_Intron|HSD3B7_uc002eag.2_Intron|HSD3B7_uc002eah.2_Missense_Mutation_p.R190C	NM_025193	NP_079469	Q9H2F3	3BHS7_HUMAN	hydroxy-delta-5-steroid dehydrogenase, 3 beta-	190					bile acid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	3-beta-hydroxy-delta5-steroid dehydrogenase activity|binding|cholest-5-ene-3-beta,7-alpha-diol 3-beta-dehydrogenase activity				0						GTGTGCCCTTCGTCCCACGGG	0.682		NaN											0	0	0	0.009096	0	4	49									
FUS	2521	broad.mit.edu	37	16	31201394	31201394	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr16:31201394C>A	uc002ebf.2	+	11	1183	c.1100C>A	c.(1099-1101)TCA>TAA	p.S367*	FUS_uc002ebh.2_Nonsense_Mutation_p.S366*|FUS_uc002ebg.2_Nonsense_Mutation_p.S162*|FUS_uc002ebi.2_Nonsense_Mutation_p.S368*|FUS_uc002ebj.2_Nonsense_Mutation_p.S163*|FUS_uc010caj.1_Nonsense_Mutation_p.S58*	NM_004960	NP_004951	P35637	FUS_HUMAN	fusion (involved in t(12;16) in malignant	367	RRM.				cell death|nuclear mRNA splicing, via spliceosome	nucleoplasm	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		FUS/DDIT3(623)|FUS/ERG(163)|FUS/CREB3L2(158)|FUS/CREB3L1(6)|FUS/ATF1(4)|FUS/FEV(2)	soft_tissue(791)|haematopoietic_and_lymphoid_tissue(153)|bone(12)|breast(2)	958		Renal(780;0.000219)|Breast(268;0.00957)|Hepatocellular(780;0.121)		GBM - Glioblastoma multiforme(240;2.31e-05)|Kidney(780;0.000209)		ATCAAGGTCTCATTTGCTACT	0.478		NaN	T	DDIT3|ERG|FEV|ATF1|CREB3L2|CREB3L1	liposarcoma|AML|Ewing sarcoma|angiomatoid fibrous histiocytoma|fibromyxoid sarcoma								1	0	0.00024832	0.009096	0.000257326	4	22									
GNAO1	2775	broad.mit.edu	37	16	56388944	56388944	+	Silent	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr16:56388944C>G	uc002eiu.3	+	8	1941	c.1044C>G	c.(1042-1044)CTC>CTG	p.L348L		NM_020988	NP_066268	P09471	GNAO_HUMAN	guanine nucleotide binding protein, alpha	348					dopamine receptor signaling pathway|G-protein signaling, coupled to cAMP nucleotide second messenger|muscle contraction	heterotrimeric G-protein complex	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|metabotropic serotonin receptor binding|signal transducer activity			lung(1)|breast(1)	2		all_neural(199;0.159)				CCAACAACCTCCGGGGCTGCG	0.483		NaN											0	0	0	0.006214	0	6	71									
CNOT1	23019	broad.mit.edu	37	16	58576138	58576138	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr16:58576138C>T	uc002env.2	-	33	4970	c.4677G>A	c.(4675-4677)CTG>CTA	p.L1559L	CNOT1_uc002enw.2_RNA|CNOT1_uc002enu.3_Silent_p.L1554L|CNOT1_uc010vik.1_Silent_p.L516L	NM_016284	NP_057368	A5YKK6	CNOT1_HUMAN	CCR4-NOT transcription complex, subunit 1	1559					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol				ovary(4)|central_nervous_system(2)	6				Kidney(780;0.0722)|OV - Ovarian serous cystadenocarcinoma(108;0.173)|Epithelial(162;0.239)		TTCTCACTTTCAGCCTGATTT	0.418		NaN											0	0	0	0.001984	0	7	43									
FHOD1	29109	broad.mit.edu	37	16	67265134	67265134	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr16:67265134G>C	uc002esl.2	-	17	2736	c.2624C>G	c.(2623-2625)TCT>TGT	p.S875C	FHOD1_uc002esk.2_5'Flank|FHOD1_uc010ced.2_Missense_Mutation_p.S682C	NM_013241	NP_037373	Q9Y613	FHOD1_HUMAN	formin homology 2 domain containing 1	875	FH2.				actin cytoskeleton organization	cytoplasm|cytoskeleton|nucleus	actin binding			breast(2)|ovary(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.000691)|Epithelial(162;0.00462)|all cancers(182;0.0434)		ATAGAGGTCAGAGGACTCAGG	0.582		NaN											0	0	0	0.00308	0	7	46									
FAM65A	79567	broad.mit.edu	37	16	67575769	67575769	+	Splice_Site	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr16:67575769G>C	uc010vjp.1	+	13	1237	c.1141_splice	c.e13-1	p.N381_splice	FAM65A_uc010cei.1_Splice_Site_p.N203_splice|FAM65A_uc002eth.2_Splice_Site_p.N361_splice|FAM65A_uc010cej.2_Splice_Site_p.N364_splice|FAM65A_uc002eti.1_Splice_Site_p.N324_splice|FAM65A_uc010vjq.1_Splice_Site_p.N375_splice|FAM65A_uc002etj.1_Splice_Site_p.N360_splice|FAM65A_uc002etk.2_Splice_Site_p.N360_splice	NM_024519	NP_078795	Q6ZS17	FA65A_HUMAN	hypothetical protein LOC79567							cytoplasm	binding			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		CTCTTTCTCAGAACATGCTGC	0.577		NaN											0	0	0	0.009096	0	4	57									
NFATC3	4775	broad.mit.edu	37	16	68160443	68160443	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr16:68160443G>A	uc002evo.1	+	3	1541	c.1331G>A	c.(1330-1332)CGA>CAA	p.R444Q	NFATC3_uc010vkl.1_5'UTR|NFATC3_uc010vkm.1_5'UTR|NFATC3_uc010vkn.1_5'UTR|NFATC3_uc010vko.1_5'UTR|NFATC3_uc010vkp.1_5'UTR|NFATC3_uc010vkq.1_5'UTR|NFATC3_uc002evl.2_Intron|NFATC3_uc002evk.2_Missense_Mutation_p.R444Q|NFATC3_uc002evm.1_Missense_Mutation_p.R444Q|NFATC3_uc002evn.1_Missense_Mutation_p.R444Q|NFATC3_uc010vkr.1_5'UTR|NFATC3_uc010vks.1_5'UTR|NFATC3_uc010vkt.1_5'UTR|NFATC3_uc010vku.1_5'UTR|NFATC3_uc010vkv.1_5'UTR|NFATC3_uc010vkw.1_5'UTR|NFATC3_uc010vkx.1_5'UTR|NFATC3_uc010vky.1_5'UTR|NFATC3_uc010vkz.1_5'UTR|NFATC3_uc010vla.1_5'UTR|NFATC3_uc010vlb.1_5'UTR|NFATC3_uc010vlc.1_5'UTR	NM_173165	NP_775188	Q12968	NFAC3_HUMAN	nuclear factor of activated T-cells,	444	RHD.|				inflammatory response|transcription from RNA polymerase II promoter	nucleolus|plasma membrane	DNA binding			upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	3		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0119)|Epithelial(162;0.0452)|all cancers(182;0.24)		ACTCATCATCGAGCCCATTAT	0.443		NaN											0	0	0	0.00308	0	7	74									
C16orf7	9605	broad.mit.edu	37	16	89775292	89775292	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr16:89775292C>A	uc002fom.1	-	13	1795	c.1670G>T	c.(1669-1671)GGG>GTG	p.G557V	C16orf7_uc002fol.1_Missense_Mutation_p.G487V|uc002fon.1_5'Flank	NM_004913	NP_004904	Q9Y2B5	CP007_HUMAN	chromosome 16 open reading frame 7	557	VPS9.				ATP synthesis coupled proton transport		GTPase activator activity|transporter activity				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0273)		GGGCGGGGGCCCGGCCTGGGG	0.667		NaN											1	0	2.7689e-08	0.001984	2.9988e-08	5	19									
ENO3	2027	broad.mit.edu	37	17	4859247	4859247	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:4859247C>T	uc002gab.3	+	9	970	c.876C>T	c.(874-876)ATC>ATT	p.I292I	ENO3_uc002gac.3_Silent_p.I292I|ENO3_uc010vss.1_Silent_p.I249I|ENO3_uc010vst.1_Silent_p.I128I	NM_053013	NP_443739	P13929	ENOB_HUMAN	enolase 3	292					gluconeogenesis|glycolysis	phosphopyruvate hydratase complex	magnesium ion binding|phosphopyruvate hydratase activity			ovary(1)	1						TGGTCTCCATCGAAGACCCCT	0.358		NaN											0	0	0	0.003755	0	29	234									
TP53	7157	broad.mit.edu	37	17	7577085	7577085	+	Missense_Mutation	SNP	C	C	T	rs112431538		TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:7577085C>T	uc002gim.2	-	8	1047	c.853G>A	c.(853-855)GAG>AAG	p.E285K	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.E285K|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E153K|TP53_uc010cng.1_Missense_Mutation_p.E153K|TP53_uc002gii.1_Missense_Mutation_p.E153K|TP53_uc010cnh.1_Missense_Mutation_p.E285K|TP53_uc010cni.1_Missense_Mutation_p.E285K|TP53_uc002gij.2_Missense_Mutation_p.E285K	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	285	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> K (in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).|E -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|E -> A (in a sporadic cancer; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E285K(95)|p.E285*(16)|p.E285V(13)|p.0?(7)|p.E285Q(4)|p.E285E(3)|p.E285G(3)|p.E285A(2)|p.?(2)|p.R283fs*16(2)|p.E285_N288delEEEN(1)|p.R282_E287delRRTEEE(1)|p.T284_G293del10(1)|p.G279fs*59(1)|p.E285fs*13(1)|p.L265_K305del41(1)|p.T284fs*57(1)|p.R283fs*56(1)|p.V272_K292del21(1)|p.R283fs*59(1)|p.C275fs*20(1)|p.E285_L289delEEENL(1)|p.E285fs*60(1)|p.E285fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCTCTTCCTCTGTGCGCCGG	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.00499	0	18	32									
MYH2	4620	broad.mit.edu	37	17	10440759	10440759	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:10440759G>C	uc010coi.2	-	16	1816	c.1688C>G	c.(1687-1689)TCT>TGT	p.S563C	uc002gml.1_Intron|MYH2_uc002gmp.3_Missense_Mutation_p.S563C|MYH2_uc010coj.2_Missense_Mutation_p.S563C	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	563	Myosin head-like.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						GAAGTTGGCAGACTTGCCCAG	0.532		NaN											0	0	0	0.006214	0	9	119									
DNAH9	1770	broad.mit.edu	37	17	11522879	11522879	+	Silent	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:11522879C>G	uc002gne.2	+	6	1199	c.1131C>G	c.(1129-1131)CTC>CTG	p.L377L		NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	377	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CTAATTATCTCAGCCCAGAAG	0.448		NaN											0	0	0	0.004482	0	6	93									
TEKT3	64518	broad.mit.edu	37	17	15234758	15234758	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:15234758G>A	uc002gon.2	-	3	332	c.145C>T	c.(145-147)CCT>TCT	p.P49S		NM_031898	NP_114104	Q9BXF9	TEKT3_HUMAN	tektin 3	49					microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(2)	2				UCEC - Uterine corpus endometrioid carcinoma (92;0.0877)		GGTCTCCAAGGAAGGCTCAGG	0.542		NaN											0	0	0	0.009096	0	4	30									
ZNF286A	57335	broad.mit.edu	37	17	15604513	15604513	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:15604513G>C	uc010cot.2	+	3	481	c.85G>C	c.(85-87)GAG>CAG	p.E29Q	ZNF286A_uc002goz.3_5'UTR|ZNF286A_uc010vwa.1_Missense_Mutation_p.E29Q|ZNF286A_uc002gpa.2_Missense_Mutation_p.E29Q	NM_001130842	NP_001124314	Q9HBT8	Z286A_HUMAN	zinc finger protein 286	29					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)|READ - Rectum adenocarcinoma(1115;0.0222)|BRCA - Breast invasive adenocarcinoma(8;0.0781)		GAGCACAGAAGAGGGAGAAGT	0.498		NaN											0	0	0	0.004672	0	3	188									
NCOR1	9611	broad.mit.edu	37	17	15967466	15967466	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:15967466C>T	uc002gpo.2	-	35	5377	c.5137G>A	c.(5137-5139)GAG>AAG	p.E1713K	NCOR1_uc002gpn.2_Missense_Mutation_p.E1729K|NCOR1_uc002gpm.2_Missense_Mutation_p.E233K|NCOR1_uc010vwb.1_Missense_Mutation_p.E297K|NCOR1_uc010coy.2_Missense_Mutation_p.E621K|NCOR1_uc010vwc.1_Missense_Mutation_p.E523K	NM_006311	NP_006302	O75376	NCOR1_HUMAN	nuclear receptor co-repressor 1	1713	Interaction with ETO.|Interaction with C1D (By similarity).				cellular lipid metabolic process|chromatin modification|negative regulation of JNK cascade|regulation of glycolysis by negative regulation of transcription from an RNA polymerase II promoter|regulation of lipid transport by negative regulation of transcription from an RNA polymerase II promoter|spindle assembly|transcription from RNA polymerase II promoter	nuclear chromatin|spindle microtubule|transcriptional repressor complex	histone deacetylase binding|transcription corepressor activity|transcription regulatory region DNA binding			upper_aerodigestive_tract(2)|ovary(1)|central_nervous_system(1)|kidney(1)	5				UCEC - Uterine corpus endometrioid carcinoma (92;0.101)		cgttccctctcAGCACTTGCA	0.363		NaN											0	0	0	0.009096	0	3	67									
UBB	7314	broad.mit.edu	37	17	16285788	16285788	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:16285788C>T	uc002gpx.2	+	2	705	c.567C>T	c.(565-567)CCC>CCT	p.P189P	UBB_uc010vwe.1_Silent_p.P113P	NM_018955	NP_061828	P0CG47	UBB_HUMAN	ubiquitin B precursor	189	Ubiquitin-like 3.				activation of MAPK activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|anti-apoptosis|apoptosis|cellular membrane organization|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA repair|endosome transport|epidermal growth factor receptor signaling pathway|G1/S transition of mitotic cell cycle|I-kappaB kinase/NF-kappaB cascade|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|M/G1 transition of mitotic cell cycle|mRNA metabolic process|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of type I interferon production|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|S phase of mitotic cell cycle|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|viral reproduction	cytosol|endocytic vesicle membrane|endosome membrane|nucleoplasm|plasma membrane	protein binding			skin(3)	3				UCEC - Uterine corpus endometrioid carcinoma (92;0.0822)		AAGGCATCCCCCCCGACCAGC	0.552		NaN											0	0	0	0.004672	0	3	61									
KIAA0100	9703	broad.mit.edu	37	17	26958554	26958554	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:26958554G>A	uc002hbu.2	-	23	4341	c.4242C>T	c.(4240-4242)CAC>CAT	p.H1414H		NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	1414						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					AGCTCAGCAGGTGGGTCTTTG	0.483		NaN											0	0	0	0.004482	0	6	77									
DHRS13	147015	broad.mit.edu	37	17	27228598	27228598	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:27228598C>T	uc002hde.3	-	3	410	c.283G>A	c.(283-285)GAC>AAC	p.D95N	DHRS13_uc002hdd.3_Missense_Mutation_p.D45N|DHRS13_uc010wba.1_Intron	NM_144683	NP_653284	Q6UX07	DHR13_HUMAN	dehydrogenase/reductase (SDR family) member 13	95						extracellular region	binding|oxidoreductase activity				0	all_cancers(5;2.12e-15)|all_epithelial(6;3.44e-19)|Lung NSC(42;0.01)		Epithelial(11;1.59e-06)|all cancers(11;9.27e-06)|BRCA - Breast invasive adenocarcinoma(11;5.78e-05)|OV - Ovarian serous cystadenocarcinoma(11;0.0602)			CTGGCCAAGTCCAAGGCCATG	0.602		NaN											0	0	0	0.000602	0	3	81									
EFCAB5	374786	broad.mit.edu	37	17	28296147	28296147	+	Nonsense_Mutation	SNP	A	A	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:28296147A>T	uc002het.2	+	4	721	c.529A>T	c.(529-531)AAA>TAA	p.K177*	EFCAB5_uc010wbi.1_Intron|EFCAB5_uc010wbj.1_Nonsense_Mutation_p.K121*|EFCAB5_uc010wbk.1_Intron|EFCAB5_uc010csd.2_RNA|EFCAB5_uc010cse.2_Nonsense_Mutation_p.K56*|EFCAB5_uc010csf.2_Nonsense_Mutation_p.K56*	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	177							calcium ion binding			ovary(1)|skin(1)	2						TTTGCTTGACAAACTTCTACC	0.378		NaN											0	0	0	0.004672	0	3	33									
LRRC37B	114659	broad.mit.edu	37	17	30348952	30348952	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:30348952G>C	uc002hgu.2	+	1	798	c.787G>C	c.(787-789)GAG>CAG	p.E263Q	LRRC37B_uc010wbx.1_Missense_Mutation_p.E181Q|LRRC37B_uc010csu.2_Missense_Mutation_p.E263Q	NM_052888	NP_443120	Q96QE4	LR37B_HUMAN	leucine rich repeat containing 37B precursor	263	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2		Myeloproliferative disorder(56;0.0255)|all_hematologic(16;0.111)|Ovarian(249;0.182)|Breast(31;0.244)				ATTCCATCTAGAGCCCAAAAG	0.547		NaN											0	0	0	0.003163	0	13	146									
TMEM132E	124842	broad.mit.edu	37	17	32964905	32964905	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:32964905C>T	uc002hif.2	+	10	2937	c.2609C>T	c.(2608-2610)ACC>ATC	p.T870I		NM_207313	NP_997196	Q6IEE7	T132E_HUMAN	transmembrane protein 132E precursor	870	Cytoplasmic (Potential).					integral to membrane				central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(366;0.231)		CCGCTGGAAACCGTGCCCGCC	0.706		NaN											0	0	0	0.001984	0	6	22									
SLFN5	162394	broad.mit.edu	37	17	33591520	33591520	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:33591520G>C	uc002hjf.3	+	4	1574	c.1457G>C	c.(1456-1458)GGG>GCG	p.G486A	SLFN5_uc010wcg.1_Intron	NM_144975	NP_659412	Q08AF3	SLFN5_HUMAN	schlafen family member 5	486					cell differentiation		ATP binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0191)		GGCTACACTGGGAGGTTATGC	0.453		NaN											0	0	0	0.00308	0	8	61									
DHRS11	79154	broad.mit.edu	37	17	34956406	34956406	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:34956406C>T	uc002hnd.2	+	6	895	c.681C>T	c.(679-681)CTC>CTT	p.L227L	MRM1_uc002hne.2_5'Flank|MRM1_uc002hnf.2_5'Flank	NM_024308	NP_077284	Q6UWP2	DHR11_HUMAN	short-chain dehydrogenase/reductase precursor	227						extracellular region	binding|oxidoreductase activity				0						CTCAGTGTCTCAAACCCGAGG	0.567		NaN											0	0	0	0.001984	0	5	31									
MLLT6	4302	broad.mit.edu	37	17	36877001	36877001	+	Splice_Site	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:36877001G>A	uc002hqi.3	+	16	2455	c.2442_splice	c.e16+1	p.E814_splice	MLLT6_uc002hqj.2_Missense_Mutation_p.V250M|MLLT6_uc002hqk.3_Splice_Site_p.E145_splice	NM_005937	NP_005928	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia						regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|prostate(1)|lung(1)|skin(1)	6	Breast(7;4.43e-21)					TTCTTCTGAGGTGGGCGCTAC	0.632		NaN	T	MLL	AL								0	0	0	0.001168	0	5	38									
NR1D1	9572	broad.mit.edu	37	17	38250311	38250311	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:38250311C>T	uc002htz.1	-	7	2125	c.1499G>A	c.(1498-1500)CGC>CAC	p.R500H	NR1D1_uc010cwq.1_RNA|NR1D1_uc010cwr.1_Missense_Mutation_p.R114H	NM_021724	NP_068370	P20393	NR1D1_HUMAN	nuclear receptor subfamily 1, group D, member 1	500					cellular response to lipopolysaccharide|negative regulation of receptor biosynthetic process|negative regulation of toll-like receptor 4 signaling pathway|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			skin(1)	1	Colorectal(19;0.000442)					GTAGGTGGTGCGGCTTAGGAA	0.572		NaN											0	0	0	0.014323	0	17	170									
ACBD4	79777	broad.mit.edu	37	17	43214493	43214493	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:43214493G>A	uc002iid.2	+	5	746	c.402G>A	c.(400-402)CTG>CTA	p.L134L	ACBD4_uc010wjj.1_Silent_p.L134L|ACBD4_uc002iie.2_Silent_p.L134L|ACBD4_uc002iif.2_Silent_p.L134L|ACBD4_uc002iic.2_Silent_p.L134L|ACBD4_uc010dae.2_Silent_p.L56L	NM_001135707	NP_001129179	Q8NC06	ACBD4_HUMAN	acyl-Coenzyme A binding domain containing 4	134							fatty-acyl-CoA binding			ovary(1)|kidney(1)	2						AGACCTTCCTGAGAAGGGTCA	0.607		NaN											0	0	0	0.000602	0	3	52									
HOXB1	3211	broad.mit.edu	37	17	46606964	46606964	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:46606964G>A	uc002ink.1	-	2	857	c.851C>T	c.(850-852)TCA>TTA	p.S284L		NM_002144	NP_002135	P14653	HXB1_HUMAN	homeobox B1	284						nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CGACTGGTCTGAGGCATCTCC	0.637		NaN											0	0	0	0.001984	0	6	48									
HOXB1	3211	broad.mit.edu	37	17	46607120	46607120	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:46607120C>T	uc002ink.1	-	2	701	c.695G>A	c.(694-696)CGG>CAG	p.R232Q		NM_002144	NP_002135	P14653	HXB1_HUMAN	homeobox B1	232	Homeobox.					nucleus	protein domain specific binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CTCCACCCTCCGGGCCCGGCT	0.572		NaN											0	0	0	0.003163	0	14	172									
CACNA1G	8913	broad.mit.edu	37	17	48701395	48701395	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:48701395C>T	uc002irk.1	+	36	6560	c.6188C>T	c.(6187-6189)CCC>CTC	p.P2063L	CACNA1G_uc002irj.1_Missense_Mutation_p.P1936L|CACNA1G_uc002irl.1_Missense_Mutation_p.P1947L|CACNA1G_uc002irm.1_Missense_Mutation_p.P1984L|CACNA1G_uc002irn.1_Missense_Mutation_p.P1929L|CACNA1G_uc002iro.1_Missense_Mutation_p.P1936L|CACNA1G_uc002irp.1_Missense_Mutation_p.P2018L|CACNA1G_uc002irq.1_Missense_Mutation_p.P2040L|CACNA1G_uc002irr.1_Missense_Mutation_p.P1970L|CACNA1G_uc002irs.1_Missense_Mutation_p.P2007L|CACNA1G_uc002irt.1_Missense_Mutation_p.P1952L|CACNA1G_uc002irv.1_Missense_Mutation_p.P1959L|CACNA1G_uc002irw.1_Missense_Mutation_p.P1992L|CACNA1G_uc002iru.1_Missense_Mutation_p.P2029L|CACNA1G_uc002irx.1_Missense_Mutation_p.P1883L|CACNA1G_uc002iry.1_Missense_Mutation_p.P1872L|CACNA1G_uc002irz.1_Missense_Mutation_p.P1876L|CACNA1G_uc002isa.1_Missense_Mutation_p.P1849L|CACNA1G_uc002isb.1_Missense_Mutation_p.P1890L|CACNA1G_uc002isc.1_Missense_Mutation_p.P1965L|CACNA1G_uc002isd.1_Missense_Mutation_p.P1858L|CACNA1G_uc002ise.1_Missense_Mutation_p.P1886L|CACNA1G_uc002isf.1_Missense_Mutation_p.P1913L|CACNA1G_uc002isg.1_Missense_Mutation_p.P1831L|CACNA1G_uc002ish.1_Missense_Mutation_p.P1838L|CACNA1G_uc002isi.1_Missense_Mutation_p.P1826L	NM_018896	NP_061496	O43497	CAC1G_HUMAN	voltage-dependent calcium channel alpha 1G	2063	Cytoplasmic (Potential).				axon guidance	voltage-gated calcium channel complex	low voltage-gated calcium channel activity			breast(1)	1	Breast(11;6.7e-17)		BRCA - Breast invasive adenocarcinoma(22;7.52e-09)		Ethosuximide(DB00593)|Flunarizine(DB04841)|Levetiracetam(DB01202)|Mibefradil(DB01388)|Pimozide(DB01100)|Trimethadione(DB00347)|Verapamil(DB00661)|Zonisamide(DB00909)	GCCGAGGGGCCCCTGGGACAC	0.612		NaN											0	0	0	0.001855	0	10	55									
C17orf71	55181	broad.mit.edu	37	17	57289713	57289713	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:57289713G>C	uc002ixi.2	+	2	1813	c.1771G>C	c.(1771-1773)GAG>CAG	p.E591Q		NM_018149	NP_060619	Q8ND04	SMG8_HUMAN	SMG8 protein	591					nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|regulation of protein kinase activity		protein binding				0	all_neural(34;0.0837)|Medulloblastoma(34;0.0922)					AGAAAAACCAGAGGCTGATAG	0.408		NaN											0	0	0	0.00308	0	6	135									
USP32	84669	broad.mit.edu	37	17	58313541	58313541	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:58313541G>A	uc002iyo.1	-	12	1483	c.1197C>T	c.(1195-1197)ATC>ATT	p.I399I	USP32_uc002iyn.1_Silent_p.I69I	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	399	DUSP.				protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			ACTGCATGGAGATGATAAACC	0.393		NaN											0	0	0	0.010729	0	8	172									
USP32	84669	broad.mit.edu	37	17	58422944	58422944	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:58422944C>T	uc002iyo.1	-	2	370	c.84G>A	c.(82-84)CTG>CTA	p.L28L	USP32_uc010wov.1_Silent_p.L28L	NM_032582	NP_115971	Q8NFA0	UBP32_HUMAN	ubiquitin specific protease 32	28					protein deubiquitination|ubiquitin-dependent protein catabolic process	Golgi apparatus|membrane	calcium ion binding|cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|breast(2)|large_intestine(1)	5	all_neural(34;0.0878)|Medulloblastoma(34;0.0922)		Epithelial(12;2.02e-11)|all cancers(12;5.23e-10)|Colorectal(3;0.198)			AAGCATCCTTCAGTCGTTTTA	0.458		NaN											0	0	0	0.000602	0	4	79									
ACE	1636	broad.mit.edu	37	17	61568636	61568636	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:61568636G>T	uc002jau.1	+	19	2828	c.2806G>T	c.(2806-2808)GTG>TTG	p.V936L	ACE_uc002jav.1_Missense_Mutation_p.V362L|ACE_uc010ddv.1_Missense_Mutation_p.V163L|ACE_uc010wpj.1_Missense_Mutation_p.V362L|ACE_uc002jaw.1_RNA|ACE_uc010wpk.1_Missense_Mutation_p.V182L	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	936	Extracellular (Potential).|Peptidase M2 2.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	GCTGCTGCCCGTGCCTCCTGA	0.617		NaN											1	0	3.59834e-05	0.001168	3.77448e-05	6	44									
MAP3K3	4215	broad.mit.edu	37	17	61768566	61768566	+	Silent	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:61768566G>C	uc002jbg.2	+	13	1636	c.1317G>C	c.(1315-1317)CTG>CTC	p.L439L	MAP3K3_uc002jbe.2_Silent_p.L470L|MAP3K3_uc002jbf.2_Silent_p.L470L|MAP3K3_uc002jbh.2_Silent_p.L466L|MAP3K3_uc010wpo.1_Silent_p.L354L|MAP3K3_uc010wpp.1_Silent_p.L435L	NM_002401	NP_002392	Q99759	M3K3_HUMAN	mitogen-activated protein kinase kinase kinase 3	439	Protein kinase.				MAPKKK cascade|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein autophosphorylation	cytosol	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			lung(3)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)	6						AGAAGACCCTGACCATCTTCA	0.577		NaN											0	0	0	0.001168	0	5	115									
HELZ	9931	broad.mit.edu	37	17	65197255	65197255	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:65197255G>C	uc010wqk.1	-	7	606	c.419C>G	c.(418-420)TCA>TGA	p.S140*	HELZ_uc002jfv.3_RNA|HELZ_uc002jfx.3_Nonsense_Mutation_p.S140*|HELZ_uc010des.1_Nonsense_Mutation_p.S140*	NM_014877	NP_055692			helicase with zinc finger domain											ovary(1)|pancreas(1)	2	all_cancers(12;1.24e-11)|Breast(2;1.05e-17)|all_epithelial(3;3.87e-13)					CTCTGTTTCTGAGAGAAGTGT	0.343		NaN									OREG0024677	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00308	0	7	78									
SLC39A11	201266	broad.mit.edu	37	17	71027826	71027826	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:71027826G>A	uc002jjb.2	-	4	290	c.175C>T	c.(175-177)CTT>TTT	p.L59F	SLC39A11_uc002jja.2_Missense_Mutation_p.L59F|SLC39A11_uc002jjc.1_Missense_Mutation_p.L59F	NM_001159770	NP_001153242	Q8N1S5	S39AB_HUMAN	solute carrier family 39, member 11 isoform 1	59	Helical; (Potential).				zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)	1						GGGGCCAGAAGAGACCAATAG	0.537		NaN											0	0	0	0.009096	0	3	32									
DNAI2	64446	broad.mit.edu	37	17	72285872	72285872	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:72285872C>T	uc002jkf.2	+	5	706	c.607C>T	c.(607-609)CTG>TTG	p.L203L	DNAI2_uc002jkg.2_RNA|DNAI2_uc010dfp.2_RNA	NM_023036	NP_075462	Q9GZS0	DNAI2_HUMAN	dynein, axonemal, intermediate polypeptide 2	203	WD 1.				cilium assembly	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	microtubule motor activity			ovary(2)|central_nervous_system(1)	3						CATCTGGGACCTGGGTGAGAA	0.627		NaN							Kartagener_syndrome				0	0	0	0.013537	0	10	56									
ARMC7	79637	broad.mit.edu	37	17	73124975	73124975	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:73124975C>T	uc002jmw.1	+	3	741	c.439C>T	c.(439-441)CGC>TGC	p.R147C	ARMC7_uc010wru.1_3'UTR|ARMC7_uc010dga.1_RNA	NM_024585	NP_078861	Q9H6L4	ARMC7_HUMAN	armadillo repeat containing 7	147							binding			pancreas(1)	1	all_lung(278;0.14)|Lung NSC(278;0.168)		LUSC - Lung squamous cell carcinoma(166;0.162)|Lung(188;0.235)			GTGCATGCTTCGCTTCTCCCT	0.692		NaN											0	0	0	0.009096	0	3	30									
GALR2	8811	broad.mit.edu	37	17	74073116	74073117	+	Missense_Mutation	DNP	CC	CC	TT			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:74073116_74073117CC>TT	uc002jqm.1	+	2	849_850	c.768_769CC>TT	c.(766-771)ATCCTC>ATTTTC	p.L257F	ZACN_uc002jqn.2_5'Flank|ZACN_uc002jqo.2_5'Flank|ZACN_uc010dgu.2_5'Flank	NM_003857	NP_003848	O43603	GALR2_HUMAN	galanin receptor 2	257	Helical; Name=6; (Potential).				digestion|elevation of cytosolic calcium ion concentration|feeding behavior|learning or memory|muscle contraction	integral to membrane|plasma membrane	galanin receptor activity				0						ACGCGCTCATCCTCTGCGTGTG	0.663		NaN											0	0	0	0.004672	0	4	43									
ZACN	353174	broad.mit.edu	37	17	74075572	74075572	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:74075572C>G	uc002jqn.2	+	2	233	c.150C>G	c.(148-150)ATC>ATG	p.I50M	ZACN_uc002jqo.2_RNA|ZACN_uc010dgu.2_RNA	NM_180990	NP_851321	Q401N2	ZACN_HUMAN	zinc activated ligand-gated ion channel	50	Extracellular (Potential).				response to zinc ion	integral to membrane|membrane fraction|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity				0						AGGAAAGCATCCAGATCCCGA	0.547		NaN											0	0	0	0.001984	0	6	37									
RHBDF2	79651	broad.mit.edu	37	17	74477496	74477496	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:74477496C>G	uc002jrq.1	-	3	404	c.111G>C	c.(109-111)GAG>GAC	p.E37D	RHBDF2_uc002jrp.1_Missense_Mutation_p.E37D|RHBDF2_uc002jrr.1_5'UTR|RHBDF2_uc010wtf.1_Missense_Mutation_p.E37D|RHBDF2_uc002jrs.1_Missense_Mutation_p.E37D	NM_024599	NP_078875	Q6PJF5	RHDF2_HUMAN	rhomboid, veinlet-like 6 isoform 1	37	Cytoplasmic (Potential).				negative regulation of protein secretion|protein transport|proteolysis	endoplasmic reticulum membrane|integral to membrane	growth factor binding|serine-type endopeptidase activity				0						GGGCCTGGGTCTCTTTCTCGG	0.637		NaN											0	0	0	0.000602	0	3	43									
CBX8	57332	broad.mit.edu	37	17	77768460	77768460	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr17:77768460G>A	uc002jxd.1	-	5	1237	c.1144C>T	c.(1144-1146)CAA>TAA	p.Q382*		NM_020649	NP_065700	Q9HC52	CBX8_HUMAN	chromobox homolog 8	382					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear chromatin|PcG protein complex	methylated histone residue binding				0			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			AAAAAGCCTTGGTCCGTGTTA	0.498		NaN											0	0	0	0.004007	0	13	212									
DLGAP1	9229	broad.mit.edu	37	18	3879141	3879141	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr18:3879141G>A	uc002kmf.2	-	1	995	c.928C>T	c.(928-930)CAG>TAG	p.Q310*	DLGAP1_uc010wyz.1_Nonsense_Mutation_p.Q310*|DLGAP1_uc002kmk.2_Nonsense_Mutation_p.Q310*|uc002kml.1_Intron	NM_004746	NP_004737	O14490	DLGP1_HUMAN	discs large homolog-associated protein 1 isoform	310					synaptic transmission	cell junction|postsynaptic density|postsynaptic membrane				ovary(2)|pancreas(1)|skin(1)	4		Colorectal(8;0.0257)				CGTTCTTGCTGACACGACTCG	0.557		NaN											0	0	0	0.013537	0	10	97									
CEP76	79959	broad.mit.edu	37	18	12673397	12673397	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr18:12673397G>A	uc002kri.2	-	12	2103	c.1947C>T	c.(1945-1947)ATC>ATT	p.I649I	PSMG2_uc002krg.2_Intron|CEP76_uc002krh.3_Silent_p.I471I|CEP76_uc010wzz.1_Silent_p.I574I	NM_024899	NP_079175	Q8TAP6	CEP76_HUMAN	centrosomal protein 76kDa	649					G2/M transition of mitotic cell cycle|regulation of centriole replication	centriole|cytosol	protein binding				0						AAGCAAACATGATCCAAACAG	0.378		NaN											0	0	0	0.00278	0	22	133									
ANKRD30B	374860	broad.mit.edu	37	18	14850274	14850274	+	Nonsense_Mutation	SNP	A	A	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr18:14850274A>T	uc010dlo.2	+	35	3280	c.3100A>T	c.(3100-3102)AGA>TGA	p.R1034*	ANKRD30B_uc010xal.1_Nonsense_Mutation_p.R176*	NM_001145029	NP_001138501	Q9BXX2	AN30B_HUMAN	ankyrin repeat domain 30B	1119	Potential.									ovary(1)|skin(1)	2						AGAAAAAATTAGACCCGAAGA	0.279		NaN											0	0	0	0.001984	0	6	16									
WDR7	23335	broad.mit.edu	37	18	54348569	54348569	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr18:54348569G>A	uc002lgk.1	+	4	503	c.292G>A	c.(292-294)GAT>AAT	p.D98N	WDR7_uc010dpk.1_RNA|WDR7_uc002lgl.1_Missense_Mutation_p.D98N	NM_015285	NP_056100	Q9Y4E6	WDR7_HUMAN	rabconnectin-3 beta isoform 1	98	WD 2.									ovary(2)|skin(1)	3				Lung(128;0.0238)|Colorectal(16;0.0296)		GGATGTGAGTGATGGCAGATG	0.333		NaN											0	0	0	0.004007	0	16	146									
TSHZ1	10194	broad.mit.edu	37	18	72999153	72999153	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr18:72999153G>A	uc002lly.2	+	2	2219	c.1656G>A	c.(1654-1656)CAG>CAA	p.Q552Q		NM_005786	NP_005777	Q6ZSZ6	TSH1_HUMAN	teashirt family zinc finger 1	597						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Esophageal squamous(42;0.129)|Prostate(75;0.142)|Melanoma(33;0.211)		Colorectal(1;0.000501)|READ - Rectum adenocarcinoma(2;0.00226)|BRCA - Breast invasive adenocarcinoma(31;0.246)		CGGCCGTGCAGAGCGTGCAGG	0.682		NaN											0	0	0	0.009096	0	3	26									
BTBD2	55643	broad.mit.edu	37	19	1993151	1993151	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:1993151C>G	uc002lup.1	-	3	552	c.552G>C	c.(550-552)CAG>CAC	p.Q184H	BTBD2_uc002luo.1_5'Flank	NM_017797	NP_060267	Q9BX70	BTBD2_HUMAN	BTB (POZ) domain containing 2	184	BTB.					cytoplasmic mRNA processing body	protein binding			ovary(1)|skin(1)	2		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCGGGCCAATCTGCACCTCGT	0.642		NaN											0	0	0	0.004482	0	7	44									
NFIC	4782	broad.mit.edu	37	19	3382105	3382105	+	Silent	SNP	G	G	A	rs146650773	by1000genomes	TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:3382105G>A	uc010xhi.1	+	2	488	c.426G>A	c.(424-426)CCG>CCA	p.P142P	NFIC_uc002lxo.2_Silent_p.P133P|NFIC_uc010xhh.1_Silent_p.P133P|NFIC_uc002lxp.2_Silent_p.P142P|NFIC_uc010xhj.1_Silent_p.P142P|NFIC_uc002lxq.1_Silent_p.P94P	NM_205843	NP_995315	P08651	NFIC_HUMAN	nuclear factor I/C isoform 2	142	CTF/NF-I.				DNA replication|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;7.8e-05)|Epithelial(107;2.94e-108)|BRCA - Breast invasive adenocarcinoma(158;0.00154)|STAD - Stomach adenocarcinoma(1328;0.191)		AGGGCATCCCGCTGGAGAGCA	0.672		NaN											0	0	0	0.009096	0	4	130									
CHAF1A	10036	broad.mit.edu	37	19	4428819	4428819	+	Silent	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:4428819C>G	uc002mal.2	+	8	1636	c.1536C>G	c.(1534-1536)CTC>CTG	p.L512L		NM_005483	NP_005474	Q13111	CAF1A_HUMAN	chromatin assembly factor 1, subunit A (p150)	512					cell cycle|DNA repair|DNA replication|DNA replication-dependent nucleosome assembly|protein complex assembly|regulation of transcription, DNA-dependent|transcription, DNA-dependent	CAF-1 complex|WINAC complex	chromatin binding|chromo shadow domain binding|unfolded protein binding			ovary(1)|skin(1)	2		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0148)|STAD - Stomach adenocarcinoma(1328;0.18)		TGAAAGACCTCAAAGGCCGGC	0.612		NaN						Chromatin_Structure					0	0	0	0.001855	0	11	60									
ZNRF4	148066	broad.mit.edu	37	19	5455804	5455804	+	Missense_Mutation	SNP	G	G	A	rs141487677	by1000genomes	TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:5455804G>A	uc002mca.3	+	1	379	c.302G>A	c.(301-303)CGG>CAG	p.R101Q		NM_181710	NP_859061	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4 precursor	101	Extracellular (Potential).					integral to membrane	zinc ion binding			large_intestine(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		GCAGTGGTACGGGCCGTGCTG	0.692		NaN											0	0	0	0.005443	0	18	76									
MLLT1	4298	broad.mit.edu	37	19	6270699	6270699	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:6270699G>A	uc002mek.2	-	2	248	c.84C>T	c.(82-84)TTC>TTT	p.F28F		NM_005934	NP_005925	Q03111	ENL_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	28	YEATS.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|protein binding			skin(1)	1						AGTCGTGAGTGAACCCCTCCG	0.612		NaN	T	MLL	AL						OREG0025198	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001984	0	6	54									
FBN3	84467	broad.mit.edu	37	19	8171100	8171100	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:8171100C>G	uc002mjf.2	-	37	4726	c.4705G>C	c.(4705-4707)GAG>CAG	p.E1569Q		NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	1569	EGF-like 24; calcium-binding.					proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						CCTGGCAGCTCTTGGCACTCG	0.577		NaN											0	0	0	0.00308	0	7	56									
MUC16	94025	broad.mit.edu	37	19	9025598	9025598	+	Silent	SNP	A	A	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:9025598A>G	uc002mkp.2	-	15	37060	c.36856T>C	c.(36856-36858)TTG>CTG	p.L12286L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12288	SEA 2.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CACCTGAGCAAGGTCAATCTG	0.527		NaN											0	0	0	0.00278	0	21	115									
MRPL4	51073	broad.mit.edu	37	19	10369342	10369342	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:10369342C>T	uc002mnm.2	+	9	874	c.720C>T	c.(718-720)TTC>TTT	p.F240F	MRPL4_uc002mnn.2_Silent_p.F240F|MRPL4_uc002mno.2_Silent_p.F240F	NM_146387	NP_666499	Q9BYD3	RM04_HUMAN	mitochondrial ribosomal protein L4 isoform a	240					translation	mitochondrion|ribosome	structural constituent of ribosome			ovary(1)	1		Renal(1328;0.0112)	OV - Ovarian serous cystadenocarcinoma(20;1.39e-09)|Epithelial(33;1.99e-06)|all cancers(31;4.81e-06)	Lung(535;0.00705)		TTAAGACCTTCAACTTGATCC	0.567		NaN											0	0	0	0.00308	0	7	95									
DOCK6	57572	broad.mit.edu	37	19	11323951	11323951	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:11323951C>T	uc002mqs.3	-	35	4433	c.4392G>A	c.(4390-4392)CTG>CTA	p.L1464L	DOCK6_uc010xlq.1_Silent_p.L803L	NM_020812	NP_065863	Q96HP0	DOCK6_HUMAN	dedicator of cytokinesis 6	1464					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						GTAGGAGCCTCAGGCACAGGT	0.647		NaN											0	0	0	0.001984	0	6	28									
MAST1	22983	broad.mit.edu	37	19	12985238	12985238	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:12985238C>T	uc002mvm.2	+	26	4395	c.4267C>T	c.(4267-4269)CGC>TGC	p.R1423C		NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase	1423					cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|large_intestine(1)|skin(1)	7						GACAGGCCGGCGCAGCAGCTC	0.711		NaN											0	0	0	0.00308	0	7	30									
NWD1	284434	broad.mit.edu	37	19	16908608	16908608	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:16908608G>A	uc002neu.3	+	16	3792	c.3370G>A	c.(3370-3372)GAT>AAT	p.D1124N	NWD1_uc002net.3_Missense_Mutation_p.D989N|NWD1_uc002nev.3_Missense_Mutation_p.D918N			Q149M9	NWD1_HUMAN	RecName: Full=NACHT and WD repeat domain-containing protein 1;	1124							ATP binding			skin(3)|ovary(2)|pancreas(2)	7						CATGGCCATGGATCTGGAACA	0.537		NaN											0	0	0	0.00333	0	23	221									
PGPEP1	54858	broad.mit.edu	37	19	18466806	18466806	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:18466806G>C	uc002nis.1	+	3	273	c.189G>C	c.(187-189)GAG>GAC	p.E63D	PGPEP1_uc002nir.1_RNA|PGPEP1_uc002nit.1_5'UTR|PGPEP1_uc010xqg.1_5'UTR	NM_017712	NP_060182	Q9NXJ5	PGPI_HUMAN	pyroglutamyl-peptidase I	63							cysteine-type peptidase activity				0						CCCTGTGGGAGAAGCACAGTC	0.567		NaN											0	0	0	0.001984	0	5	100									
CILP2	148113	broad.mit.edu	37	19	19655890	19655890	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:19655890C>T	uc002nmv.3	+	8	2621	c.2536C>T	c.(2536-2538)CGG>TGG	p.R846W	CILP2_uc002nmw.3_Missense_Mutation_p.R852W	NM_153221	NP_694953	Q8IUL8	CILP2_HUMAN	cartilage intermediate layer protein 2	846						proteinaceous extracellular matrix	carbohydrate binding|carboxypeptidase activity			ovary(1)	1						GGGGTACCGTCGGACGGACCA	0.706		NaN											0	0	0	0.000602	0	4	27									
ZNF99	7652	broad.mit.edu	37	19	22952087	22952087	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:22952087G>C	uc010xrh.1	-	2	106	c.106C>G	c.(106-108)CTG>GTG	p.L36V		NM_001080409	NP_001073878			zinc finger protein 99											ovary(1)|skin(1)	2		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.102)				CACTCCTCCAGAGCGAATTCT	0.403		NaN											0	0	0	0.013537	0	11	99									
CCDC123	84902	broad.mit.edu	37	19	33444672	33444672	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:33444672G>A	uc002nty.2	-	4	430	c.341C>T	c.(340-342)TCT>TTT	p.S114F	CCDC123_uc002ntx.2_5'UTR|CCDC123_uc010edg.2_RNA|CCDC123_uc002ntz.1_Missense_Mutation_p.S114F|CCDC123_uc002nua.2_Missense_Mutation_p.S114F|CCDC123_uc002nub.1_Missense_Mutation_p.S6F	NM_032816	NP_116205	Q96ST8	CEP89_HUMAN	coiled-coil domain containing 123	114						centrosome|spindle pole					0	Esophageal squamous(110;0.137)					GGATGGCAAAGAAGATCTTCT	0.443		NaN											0	0	0	0.007413	0	9	91									
MLL4	9757	broad.mit.edu	37	19	36223466	36223466	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:36223466G>C	uc010eei.2	+	29	6016	c.6016G>C	c.(6016-6018)GAG>CAG	p.E2006Q		NM_014727	NP_055542	Q9UMN6	MLL4_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 4	2006					chromatin-mediated maintenance of transcription		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			central_nervous_system(6)|breast(2)|ovary(1)|kidney(1)|skin(1)	11	all_lung(56;3.33e-07)|Lung NSC(56;5.02e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CTTCCAGGAAGAGATTGTAGC	0.667		NaN											0	0	0	0.004482	0	8	41									
ZNF568	374900	broad.mit.edu	37	19	37441804	37441804	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:37441804G>A	uc002ofc.2	+	7	2264	c.1749G>A	c.(1747-1749)GAG>GAA	p.E583E	ZNF568_uc010efg.2_Intron|ZNF568_uc010xtn.1_Intron|ZNF568_uc002ofd.2_Silent_p.E507E|ZNF568_uc010efe.2_Silent_p.E507E|ZNF568_uc010eff.1_Intron	NM_198539	NP_940941	Q3ZCX4	ZN568_HUMAN	zinc finger protein 568	583					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)	2	Esophageal squamous(110;0.183)		COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ACACAGGGGAGAAACCCTATG	0.378		NaN											0	0	0	0.001168	0	5	93									
PAF1	54623	broad.mit.edu	37	19	39880314	39880314	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:39880314G>A	uc002old.2	-	4	433	c.258C>T	c.(256-258)CTC>CTT	p.L86L	PAF1_uc002ole.1_Silent_p.L76L|PAF1_uc010xuv.1_Intron|MED29_uc010xuw.1_5'Flank|MED29_uc002olf.2_5'Flank|MED29_uc010xux.1_5'Flank	NM_019088	NP_061961	Q8N7H5	PAF1_HUMAN	Paf1, RNA polymerase II associated factor,	86					histone H2B ubiquitination|histone monoubiquitination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			pancreas(1)	1	all_cancers(60;9.14e-07)|all_lung(34;4.03e-08)|Lung NSC(34;4.66e-08)|all_epithelial(25;1.88e-06)|Ovarian(47;0.0512)		Epithelial(26;9.6e-28)|all cancers(26;9.14e-25)|Lung(45;0.000168)|LUSC - Lung squamous cell carcinoma(53;0.000199)			CAGGATTGATGAGATCGATGG	0.572		NaN											0	0	0	0.00308	0	7	96									
MIA	8190	broad.mit.edu	37	19	41281508	41281508	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:41281508G>A	uc002opb.3	+	1	209	c.61G>A	c.(61-63)GGT>AGT	p.G21S	MIA_uc010xvt.1_RNA|RAB4B_uc002opc.1_5'Flank|RAB4B_uc002opd.1_5'Flank|RAB4B_uc002ope.1_5'Flank|EGLN2_uc010ehd.2_5'Flank	NM_006533	NP_006524	Q16674	MIA_HUMAN	melanoma inhibitory activity precursor	21					cell proliferation	extracellular space	growth factor activity				0			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)	GBM - Glioblastoma multiforme(1328;0.0199)		CTCCGGACCTGGTGTCAGGGG	0.622		NaN											0	0	0	0.006214	0	8	194									
ARHGEF1	9138	broad.mit.edu	37	19	42392170	42392170	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:42392170G>C	uc002orx.2	+	2	126	c.17G>C	c.(16-18)CGA>CCA	p.R6P	ARHGEF1_uc002orw.1_Missense_Mutation_p.R6P|ARHGEF1_uc002ory.2_Missense_Mutation_p.R6P|ARHGEF1_uc002orz.2_5'UTR|ARHGEF1_uc002osa.2_Missense_Mutation_p.R21P|ARHGEF1_uc002osb.2_Missense_Mutation_p.R21P	NM_004706	NP_004697	Q92888	ARHG1_HUMAN	Rho guanine nucleotide exchange factor 1 isoform	6					cell proliferation|negative regulation of axonogenesis|nerve growth factor receptor signaling pathway|positive regulation of axonogenesis|regulation of Rho protein signal transduction|Rho protein signal transduction	cytosol|plasma membrane	GTPase activator activity|protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(3)|large_intestine(1)	4		Renal(1328;0.000518)|Hepatocellular(1079;0.0046)|Medulloblastoma(540;0.0425)		Epithelial(262;5.89e-46)|GBM - Glioblastoma multiforme(1328;2.49e-12)|STAD - Stomach adenocarcinoma(1328;0.00644)		GACTTCGCCCGAGGGGCGGTG	0.657		NaN											0	0	0	0.000602	0	4	24									
ATP1A3	478	broad.mit.edu	37	19	42474362	42474362	+	Silent	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:42474362G>C	uc002osg.2	-	18	2671	c.2517C>G	c.(2515-2517)CTC>CTG	p.L839L	ATP1A3_uc010xwf.1_Silent_p.L850L|ATP1A3_uc010xwg.1_Silent_p.L809L|ATP1A3_uc010xwh.1_Silent_p.L852L|ATP1A3_uc002osh.2_Silent_p.L839L	NM_152296	NP_689509	P13637	AT1A3_HUMAN	Na+/K+ -ATPase alpha 3 subunit	839	Helical; (Potential).				ATP biosynthetic process	endoplasmic reticulum|Golgi apparatus	ATP binding|metal ion binding|sodium:potassium-exchanging ATPase activity			ovary(1)|pancreas(1)	2						CCATGCTGATGAGTCTCTCAT	0.612		NaN											0	0	0	0.00308	0	7	66									
ZNF526	116115	broad.mit.edu	37	19	42728808	42728808	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:42728808G>A	uc002osz.1	+	3	409	c.253G>A	c.(253-255)GAG>AAG	p.E85K		NM_133444	NP_597701	Q8TF50	ZN526_HUMAN	zinc finger protein 526	85					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0704)				TGCTGTCTCAGAGGAGGAGGC	0.582		NaN											0	0	0	0.004482	0	9	55									
ZNF404	342908	broad.mit.edu	37	19	44377405	44377405	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:44377405G>A	uc002oxs.3	-	2	961	c.952C>T	c.(952-954)CAT>TAT	p.H318Y		NM_001033719	NP_001028891	Q494X3	ZN404_HUMAN	zinc finger protein 404	321	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Prostate(69;0.0352)				TCACCAGTATGACTTCTTTGA	0.373		NaN											0	0	0	0.001168	0	5	50									
ZNF155	7711	broad.mit.edu	37	19	44500376	44500376	+	Missense_Mutation	SNP	C	C	G	rs138952990		TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:44500376C>G	uc002oxy.1	+	5	572	c.367C>G	c.(367-369)CAG>GAG	p.Q123E	ZNF155_uc002oxz.1_Missense_Mutation_p.Q123E|ZNF155_uc010xwt.1_Missense_Mutation_p.Q134E	NM_003445	NP_003436	Q12901	ZN155_HUMAN	zinc finger protein 155	123						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			large_intestine(1)|ovary(1)	2		Prostate(69;0.0352)				AAATAACTCTCAGTTCTTTGA	0.463		NaN											0	0	0	0.001984	0	7	100									
IRF2BP1	26145	broad.mit.edu	37	19	46387392	46387392	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:46387392C>T	uc002pds.1	-	1	1985	c.1641G>A	c.(1639-1641)CCG>CCA	p.P547P		NM_015649	NP_056464	Q8IU81	I2BP1_HUMAN	interferon regulatory factor 2 binding protein	547	Cys-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0402)|Epithelial(262;0.231)		TGTCTCCGCTCGGGCAGTACA	0.637		NaN											0	0	0	0.001168	0	4	37									
TSKS	60385	broad.mit.edu	37	19	50243088	50243088	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:50243088C>A	uc002ppm.2	-	11	1735	c.1724G>T	c.(1723-1725)GGA>GTA	p.G575V		NM_021733	NP_068379	Q9UJT2	TSKS_HUMAN	testis-specific kinase substrate	575							protein binding			large_intestine(1)|skin(1)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.00153)|GBM - Glioblastoma multiforme(134;0.0145)		ACTGCTGCCTCCCCCCATTGT	0.552		NaN											1	0	0.000219431	0.00245	0.000228178	13	102									
ZNF528	84436	broad.mit.edu	37	19	52909217	52909217	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:52909217C>A	uc002pzh.2	+	5	499	c.73C>A	c.(73-75)CTG>ATG	p.L25M	ZNF528_uc002pzi.2_Translation_Start_Site	NM_032423	NP_115799	Q3MIS6	ZN528_HUMAN	zinc finger protein 528	25	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(134;0.00249)|OV - Ovarian serous cystadenocarcinoma(262;0.00817)		GTGGAAATGCCTGGACCCTGC	0.488		NaN											1	0	8.69298e-16	0.006999	9.57025e-16	42	145									
C19orf51	352909	broad.mit.edu	37	19	55672075	55672075	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:55672075C>T	uc002qji.1	-	9	1015	c.981G>A	c.(979-981)GCG>GCA	p.A327A	TNNI3_uc010yft.1_5'Flank|C19orf51_uc002qjh.1_Silent_p.A142A|C19orf51_uc002qjj.1_Silent_p.A374A|C19orf51_uc002qjk.1_Silent_p.A273A|C19orf51_uc002qjl.1_Silent_p.A395A			Q8N9W5	CS051_HUMAN	RecName: Full=UPF0470 protein C19orf51;	327											0			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		CGGTGGCTCTCGCGCGCCCCC	0.682		NaN									OREG0025678	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00308	0	7	61									
NLRP8	126205	broad.mit.edu	37	19	56466276	56466276	+	Silent	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:56466276C>G	uc002qmh.2	+	3	923	c.852C>G	c.(850-852)CTC>CTG	p.L284L	NLRP8_uc010etg.2_Silent_p.L284L	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	284	NACHT.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		TTCTGCTGCTCTTGGATGGCT	0.522		NaN											0	0	0	0.008361	0	26	183									
PEG3	5178	broad.mit.edu	37	19	57328268	57328268	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:57328268G>A	uc002qnu.2	-	7	1893	c.1542C>T	c.(1540-1542)TTC>TTT	p.F514F	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Silent_p.F485F|PEG3_uc002qnv.2_Silent_p.F514F|PEG3_uc002qnw.2_Silent_p.F390F|PEG3_uc002qnx.2_Silent_p.F388F|PEG3_uc010etr.2_Silent_p.F514F	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	514	C2H2-type 2.				apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		CACTCTTATTGAAGGTCTCTC	0.458		NaN											0	0	0	0.008361	0	25	105									
ZNF543	125919	broad.mit.edu	37	19	57840469	57840469	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:57840469G>A	uc002qoi.1	+	4	1984	c.1639G>A	c.(1639-1641)GGC>AGC	p.G547S		NM_213598	NP_998763	Q08ER8	ZN543_HUMAN	zinc finger protein 543	547	C2H2-type 13.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)|pancreas(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		TTTTAATCGCGGCTCATCCCT	0.463		NaN											0	0	0	0.001984	0	5	74									
ZNF749	388567	broad.mit.edu	37	19	57956103	57956104	+	Missense_Mutation	DNP	TG	TG	CC			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:57956103_57956104TG>CC	uc002qoq.2	+	3	1841_1842	c.1587_1588TG>CC	c.(1585-1590)CATGAG>CACCAG	p.E530Q	ZNF547_uc002qpm.3_Intron	NM_001023561	NP_001018855	O43361	ZN749_HUMAN	zinc finger protein 749	530	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0264)|Lung(386;0.177)		TAGTTCAGCATGAGAAAATCCA	0.45		NaN											0	0	0	0.004672	0	3	89									
WDR35	57539	broad.mit.edu	37	2	20138060	20138060	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:20138060G>A	uc002rdi.2	-	19	2170	c.2062C>T	c.(2062-2064)CAG>TAG	p.Q688*	WDR35_uc002rdj.2_Nonsense_Mutation_p.Q677*|WDR35_uc010ext.2_RNA|WDR35_uc002rdh.2_Nonsense_Mutation_p.Q253*|WDR35_uc002rdk.3_Nonsense_Mutation_p.Q253*	NM_001006657	NP_001006658	Q9P2L0	WDR35_HUMAN	WD repeat domain 35 isoform 1	688										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TCTATGAACTGAGATGCATCT	0.418		NaN											0	0	0	0.001984	0	5	99									
PFN4	375189	broad.mit.edu	37	2	24345319	24345319	+	Silent	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:24345319C>G	uc002rfa.1	-	2	263	c.87G>C	c.(85-87)CGG>CGC	p.R29R	LOC375190_uc002rew.2_Intron|LOC375190_uc010ykl.1_5'Flank|LOC375190_uc002rfb.2_5'Flank	NM_199346	NP_955378	Q8NHR9	PROF4_HUMAN	profilin family, member 4	29					actin cytoskeleton organization	actin cytoskeleton|cytoplasm	actin binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CACACAAGCTCCGCTCCTGGA	0.413		NaN											0	0	0	0.008291	0	8	103									
ITSN2	50618	broad.mit.edu	37	2	24484496	24484496	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:24484496G>A	uc002rfe.2	-	21	2729	c.2471C>T	c.(2470-2472)GCT>GTT	p.A824V	ITSN2_uc002rff.2_Missense_Mutation_p.A797V|ITSN2_uc002rfg.2_Missense_Mutation_p.A824V	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	824				KAVSPK -> FAAAST (in Ref. 6; AAD00899).	endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGGAGATACAGCTTTTTCATT	0.363		NaN											0	0	0	0.004482	0	8	66									
ZNF513	130557	broad.mit.edu	37	2	27600473	27600473	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:27600473G>A	uc002rkk.2	-	4	1765	c.1565C>T	c.(1564-1566)TCT>TTT	p.S522F	ZNF513_uc002rkj.2_Missense_Mutation_p.S460F	NM_144631	NP_653232	Q8N8E2	ZN513_HUMAN	zinc finger protein 513	522					regulation of transcription, DNA-dependent|response to stimulus|retina development in camera-type eye|transcription, DNA-dependent|visual perception	nucleus	transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGGGCCCCGAGAGCTCAAAAC	0.632		NaN											0	0	0	0.000602	0	5	49									
EIF2AK2	5610	broad.mit.edu	37	2	37374916	37374916	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:37374916C>G	uc010ynh.1	-	3	591	c.34G>C	c.(34-36)GAG>CAG	p.E12Q	EIF2AK2_uc010fab.1_Missense_Mutation_p.E12Q|EIF2AK2_uc010yng.1_Missense_Mutation_p.E12Q|EIF2AK2_uc010fac.2_Missense_Mutation_p.E12Q|EIF2AK2_uc010fad.2_Missense_Mutation_p.E12Q	NM_002759	NP_002750	P19525	E2AK2_HUMAN	eukaryotic translation initiation factor 2-alpha	12	DRBM 1.				evasion by virus of host immune response|modulation by virus of host cellular process|negative regulation of osteoblast proliferation|protein autophosphorylation|response to virus|viral infectious cycle	cytosol	ATP binding|double-stranded RNA binding|eukaryotic translation initiation factor 2alpha kinase activity|protein binding|protein phosphatase type 2A regulator activity			ovary(2)|lung(2)|pancreas(1)	5		all_hematologic(82;0.248)				TTAAGTTCCTCCATGAAGAAA	0.398		NaN											0	0	0	0.008871	0	16	127									
PLEKHH2	130271	broad.mit.edu	37	2	43968150	43968150	+	Silent	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:43968150C>G	uc010yny.1	+	21	3272	c.3189C>G	c.(3187-3189)CTC>CTG	p.L1063L	PLEKHH2_uc002rtf.3_Silent_p.L1062L	NM_172069	NP_742066	Q8IVE3	PKHH2_HUMAN	pleckstrin homology domain containing, family H	1063	MyTH4.|Helical; (Potential).					cytoplasm|cytoskeleton|integral to membrane	binding			skin(2)|central_nervous_system(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				TGTGGCTCCTCAGGCTTCACC	0.507		NaN											0	0	0	0.001855	0	12	76									
CCDC88A	55704	broad.mit.edu	37	2	55561583	55561583	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:55561583C>T	uc002ryv.2	-	15	3216	c.2374G>A	c.(2374-2376)GAA>AAA	p.E792K	CCDC88A_uc010yoz.1_Missense_Mutation_p.E792K|CCDC88A_uc010ypa.1_Missense_Mutation_p.E792K|CCDC88A_uc010ypb.1_Missense_Mutation_p.E694K|CCDC88A_uc002ryu.2_Missense_Mutation_p.E75K|CCDC88A_uc002ryw.2_Missense_Mutation_p.E75K	NM_001135597	NP_001129069	Q3V6T2	GRDN_HUMAN	coiled-coil domain containing 88A isoform 1	792	Potential.				activation of protein kinase B activity|cell migration|cellular membrane organization|DNA replication|lamellipodium assembly|microtubule cytoskeleton organization|regulation of actin cytoskeleton organization|regulation of cell proliferation|regulation of DNA replication|regulation of neuron projection development|TOR signaling cascade	cytoplasmic membrane-bounded vesicle|cytosol|endoplasmic reticulum|Golgi apparatus|lamellipodium|plasma membrane	actin binding|microtubule binding|phosphatidylinositol binding|protein homodimerization activity|protein kinase B binding			ovary(2)|skin(2)	4						GTTTGATTTTCCATCTCTAAG	0.318		NaN											0	0	0	0.009096	0	3	40									
GKN2	200504	broad.mit.edu	37	2	69173523	69173523	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:69173523C>T	uc002sfa.2	-	5	494	c.385G>A	c.(385-387)GAC>AAC	p.D129N	GKN2_uc002sfb.3_Missense_Mutation_p.D129N	NM_182536	NP_872342	Q86XP6	GKN2_HUMAN	trefoil factor interactions(z) 1 precursor	129	BRICHOS.					extracellular region					0						CAATCCACGTCTTTGATCAGA	0.443		NaN											0	0	0	0.00245	0	11	207									
ANXA4	307	broad.mit.edu	37	2	70037783	70037783	+	Missense_Mutation	SNP	G	G	A	rs144937233		TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:70037783G>A	uc002sfr.3	+	7	682	c.455G>A	c.(454-456)CGA>CAA	p.R152Q	ANXA4_uc010yqn.1_RNA|ANXA4_uc002sfs.3_Missense_Mutation_p.R130Q|ANXA4_uc010yqo.1_Missense_Mutation_p.R68Q	NM_001153	NP_001144	P09525	ANXA4_HUMAN	annexin IV	150	Annexin 2.				anti-apoptosis|signal transduction	cytoplasm	calcium ion binding|calcium-dependent phospholipid binding|phospholipase inhibitor activity				0						ATGTTCCAGCGAGTGCTGGTG	0.473		NaN											0	0	0	0.008291	0	7	56									
CLEC4F	165530	broad.mit.edu	37	2	71043444	71043444	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:71043444T>A	uc002shf.2	-	4	1146	c.1069A>T	c.(1069-1071)ACT>TCT	p.T357S	CLEC4F_uc010yqv.1_Missense_Mutation_p.T357S	NM_173535	NP_775806	Q8N1N0	CLC4F_HUMAN	C-type lectin, superfamily member 13	357	Extracellular (Potential).				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(5)	5						TGAATCTGAGTATCTGTCTGG	0.408		NaN											0	0	0	0.001984	0	7	72									
CNNM4	26504	broad.mit.edu	37	2	97475114	97475114	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:97475114C>T	uc002swx.2	+	7	2286	c.2188C>T	c.(2188-2190)CAG>TAG	p.Q730*	CNNM4_uc010yuy.1_Missense_Mutation_p.S246L	NM_020184	NP_064569	Q6P4Q7	CNNM4_HUMAN	cyclin M4	730					biomineral tissue development|ion transport|response to stimulus|visual perception	integral to membrane|plasma membrane		p.Q730*(1)		breast(2)|ovary(1)	3						GAACAGCCCTCAGTTTCCCAT	0.577		NaN											0	0	0	0.001168	0	5	40									
TBC1D8	11138	broad.mit.edu	37	2	101655103	101655103	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:101655103C>T	uc010fiv.2	-	7	1181	c.1050G>A	c.(1048-1050)GAG>GAA	p.E350E	TBC1D8_uc010yvw.1_Silent_p.E365E|TBC1D8_uc002tau.3_Silent_p.E107E	NM_001102426	NP_001095896	O95759	TBCD8_HUMAN	TBC1 domain family, member 8	350	GRAM 2.				blood circulation|positive regulation of cell proliferation	intracellular|membrane	calcium ion binding|Rab GTPase activator activity			ovary(3)	3						CCTCCATCTTCTCGATGCTCA	0.557		NaN											0	0	0	0.003163	0	11	100									
IL1F8	27177	broad.mit.edu	37	2	113783751	113783751	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:113783751T>C	uc002tiq.1	-	5	424	c.320A>G	c.(319-321)CAC>CGC	p.H107R		NM_014438	NP_055253	Q9NZH7	IL36B_HUMAN	interleukin 1 family, member 8 isoform 1	107					immune response	extracellular space	cytokine activity|interleukin-1 receptor binding			ovary(1)	1						tatgcatgtgtgaattccaac	0		NaN											0	0	0	0.013537	0	9	67									
FAM123C	205147	broad.mit.edu	37	2	131520580	131520580	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:131520580G>C	uc002trw.2	+	2	1125	c.935G>C	c.(934-936)AGT>ACT	p.S312T	FAM123C_uc010fmv.2_Missense_Mutation_p.S312T|FAM123C_uc010fms.1_Missense_Mutation_p.S312T|FAM123C_uc010fmt.1_Missense_Mutation_p.S312T|FAM123C_uc010fmu.1_Missense_Mutation_p.S312T	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	312										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		TTCTGGGACAGTGTGAATCGC	0.647		NaN											0	0	0	0.00308	0	6	35									
MCM6	4175	broad.mit.edu	37	2	136610439	136610439	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:136610439C>T	uc002tuw.2	-	12	1749	c.1673G>A	c.(1672-1674)AGA>AAA	p.R558K		NM_005915	NP_005906	Q14566	MCM6_HUMAN	minichromosome maintenance complex component 6	558					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	MCM complex	ATP binding|identical protein binding				0				BRCA - Breast invasive adenocarcinoma(221;0.166)	Atorvastatin(DB01076)	TTCCTCAATTCTTGAATGCAA	0.368		NaN											0	0	0	0.001984	0	7	46									
MARCH7	64844	broad.mit.edu	37	2	160604796	160604796	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:160604796C>G	uc002uax.2	+	5	1117	c.995C>G	c.(994-996)TCA>TGA	p.S332*	MARCH7_uc010foq.2_Nonsense_Mutation_p.S332*|MARCH7_uc010zcn.1_Nonsense_Mutation_p.S276*|MARCH7_uc010for.2_Nonsense_Mutation_p.S294*|MARCH7_uc002uay.2_RNA	NM_022826	NP_073737	Q9H992	MARH7_HUMAN	axotrophin	332	Ser-rich.						ligase activity|zinc ion binding				0						AATGTACCATCAGCTTCTGAA	0.413		NaN											0	0	0	0.009096	0	3	39									
LY75	4065	broad.mit.edu	37	2	160698844	160698844	+	Silent	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:160698844G>C	uc002ubc.3	-	24	3261	c.3192C>G	c.(3190-3192)CTC>CTG	p.L1064L	LY75_uc002ubb.3_Silent_p.L1064L|LY75_uc010fos.2_Silent_p.L1064L	NM_002349	NP_002340	O60449	LY75_HUMAN	lymphocyte antigen 75 precursor	1064	Extracellular (Potential).|C-type lectin 6.				endocytosis|immune response|inflammatory response	integral to plasma membrane	receptor activity|sugar binding				0				COAD - Colon adenocarcinoma(177;0.132)		TTTGGAGGTTGAGTATTAGGG	0.403		NaN											0	0	0	0.004482	0	7	47									
SLC4A10	57282	broad.mit.edu	37	2	162813607	162813607	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:162813607C>T	uc002ubx.3	+	20	2834	c.2650C>T	c.(2650-2652)CAT>TAT	p.H884Y	SLC4A10_uc002uby.3_Missense_Mutation_p.H854Y|SLC4A10_uc010zcs.1_Missense_Mutation_p.H865Y	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	884	Extracellular (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						CTCCATCACTCATGTCAATAG	0.493		NaN											0	0	0	0.000602	0	3	20									
METTL5	29081	broad.mit.edu	37	2	170681089	170681089	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:170681089T>C	uc002ufn.2	-	1	265	c.19A>G	c.(19-21)AAG>GAG	p.K7E	UBR3_uc010zdi.1_5'Flank|METTL5_uc002ufo.2_Missense_Mutation_p.K7E|METTL5_uc002ufp.2_Missense_Mutation_p.K7E|METTL5_uc002ufq.1_Missense_Mutation_p.K7E	NM_014168	NP_054887	Q9NRN9	METL5_HUMAN	methyltransferase like 5	7							methyltransferase activity|nucleic acid binding			central_nervous_system(1)	1						TCTAGTTCCTTAAGCCTTACT	0.468		NaN									OREG0015052	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00245	0	12	98									
TTN	7273	broad.mit.edu	37	2	179440352	179440352	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:179440352A>C	uc010zfg.1	-	275	63027	c.62803T>G	c.(62803-62805)TGT>GGT	p.C20935G	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.C14630G|TTN_uc010zfi.1_Missense_Mutation_p.C14563G|TTN_uc010zfj.1_Missense_Mutation_p.C14438G	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	21862							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			AAATATTCACACCCTTCAGAC	0.438		NaN											0	0	0	0.005443	0	9	72									
TTN	7273	broad.mit.edu	37	2	179611576	179611576	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:179611576G>C	uc002unb.2	-	46	15775	c.15551C>G	c.(15550-15552)TCT>TGT	p.S5184C	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	8703							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTCAATAAAAGATGGAGGCAT	0.413		NaN											0	0	0	0.001168	0	4	79									
PLCL1	5334	broad.mit.edu	37	2	198948543	198948543	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:198948543C>T	uc010fsp.2	+	2	593	c.302C>T	c.(301-303)TCG>TTG	p.S101L	PLCL1_uc002uuv.3_Missense_Mutation_p.S22L	NM_001114661	NP_001108133	Q15111	PLCL1_HUMAN	RecName: Full=Inactive phospholipase C-like protein 1;          Short=PLC-L1; AltName: Full=Phospholipase C-deleted in lung carcinoma; AltName: Full=Phospholipase C-related but catalytically inactive protein;          Short=PRIP;	101	Interaction with PPP1C.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			ovary(1)|skin(1)	2					Quinacrine(DB01103)	AGCATGCCATCGGAAAAGAAA	0.383		NaN											0	0	0	0.001984	0	6	47									
AOX1	316	broad.mit.edu	37	2	201505863	201505863	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:201505863G>C	uc002uvx.2	+	24	2712	c.2611G>C	c.(2611-2613)GAG>CAG	p.E871Q	AOX1_uc010zhf.1_Missense_Mutation_p.E427Q|AOX1_uc010fsu.2_Missense_Mutation_p.E237Q	NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	871					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	CCTGGACATGGAGCATTACAG	0.443		NaN											0	0	0	0.009096	0	3	45									
CASP10	843	broad.mit.edu	37	2	202073797	202073797	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:202073797C>T	uc002uxl.1	+	9	1345	c.927C>T	c.(925-927)ATC>ATT	p.I309I	CASP10_uc002uxj.1_Silent_p.I309I|CASP10_uc002uxk.1_Silent_p.I266I|CASP10_uc010fta.1_Silent_p.I242I|CASP10_uc002uxm.1_Silent_p.I266I|CASP10_uc010ftb.1_RNA	NM_032974	NP_116756	Q92851	CASPA_HUMAN	caspase 10 isoform b preproprotein	309					apoptosis|induction of apoptosis by extracellular signals|proteolysis	cytosol|plasma membrane	cysteine-type endopeptidase activity|identical protein binding|protein binding			skin(3)|ovary(1)|pancreas(1)|breast(1)	6						AAACAGAGATCCTGAGTCATG	0.264		NaN											0	0	0	0.001168	0	6	42									
CDK5R2	8941	broad.mit.edu	37	2	219825385	219825385	+	Silent	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:219825385C>G	uc002vjf.2	+	1	988	c.843C>G	c.(841-843)CTC>CTG	p.L281L		NM_003936	NP_003927	Q13319	CD5R2_HUMAN	cyclin-dependent kinase 5, regulatory subunit 2	281					regulation of cyclin-dependent protein kinase activity	cyclin-dependent protein kinase 5 holoenzyme complex	cyclin-dependent protein kinase 5 activator activity			ovary(1)	1		Renal(207;0.0474)		Epithelial(149;9.77e-07)|all cancers(144;0.000167)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CCTACCCACTCAAGCCCTTCC	0.677		NaN											0	0	0	0.001984	0	6	120									
DNER	92737	broad.mit.edu	37	2	230450662	230450662	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:230450662T>C	uc002vpv.2	-	4	906	c.759A>G	c.(757-759)ATA>ATG	p.I253M	DNER_uc010zly.1_Translation_Start_Site	NM_139072	NP_620711	Q8NFT8	DNER_HUMAN	delta-notch-like EGF repeat-containing	253	Extracellular (Potential).				central nervous system development|endocytosis|neuron migration|Notch signaling pathway|synapse assembly	dendrite|early endosome|integral to membrane|plasma membrane	calcium ion binding|clathrin binding|transmembrane receptor activity			lung(5)|ovary(2)|skin(1)	8		all_lung(227;0.00413)|Renal(207;0.0113)|Lung NSC(271;0.0211)|all_hematologic(139;0.105)|Acute lymphoblastic leukemia(138;0.175)		Epithelial(121;1.4e-11)|all cancers(144;7.7e-09)|LUSC - Lung squamous cell carcinoma(224;0.034)|Lung(119;0.0375)		TTCGTCCATCTATGAGGGAGC	0.517		NaN											0	0	0	0.004482	0	8	58									
HTR2B	3357	broad.mit.edu	37	2	231988456	231988456	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:231988456G>C	uc002vro.2	-	2	528	c.23C>G	c.(22-24)TCT>TGT	p.S8C	PSMD1_uc002vrm.1_Intron|PSMD1_uc010fxu.1_Intron|PSMD1_uc002vrn.1_Intron|HTR2B_uc010fxv.2_Missense_Mutation_p.S8C	NM_000867	NP_000858	P41595	5HT2B_HUMAN	5-hydroxytryptamine (serotonin) receptor 2B	8	Extracellular (By similarity).				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|calcium-mediated signaling|cardiac muscle hypertrophy|cellular response to calcium ion|cellular response to temperature stimulus|cGMP biosynthetic process|embryonic morphogenesis|ERK1 and ERK2 cascade|G-protein coupled receptor internalization|heart morphogenesis|intestine smooth muscle contraction|negative regulation of apoptosis|negative regulation of autophagy|neural crest cell migration|phosphatidylinositol 3-kinase cascade|phosphatidylinositol biosynthetic process|phosphorylation|positive regulation of cell division|positive regulation of cytokine production|positive regulation of cytokine secretion|positive regulation of endothelial cell proliferation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAP kinase activity|positive regulation of nitric-oxide synthase activity|protein kinase C signaling cascade|regulation of behavior|release of sequestered calcium ion into cytosol|response to drug|vasoconstriction	cytoplasm|integral to membrane|plasma membrane	calcium channel activity|drug binding|G-protein alpha-subunit binding|phosphatidylinositol phospholipase C activity|Ras GTPase activator activity|serotonin binding|serotonin receptor activity				0		Renal(207;0.025)|all_hematologic(139;0.094)|Acute lymphoblastic leukemia(138;0.164)|Medulloblastoma(418;0.232)		Epithelial(121;4.48e-11)|LUSC - Lung squamous cell carcinoma(224;0.0115)|Lung(119;0.0141)	Chlorprothixene(DB01239)|Eletriptan(DB00216)|Fenfluramine(DB00574)|Methotrimeprazine(DB01403)|Minaprine(DB00805)|Quetiapine(DB01224)|Sumatriptan(DB00669)|Tegaserod(DB01079)|Triflupromazine(DB00508)	TTGAAGTTCAGACACTCTGTA	0.423		NaN											0	0	0	0.007413	0	15	111									
ATG16L1	55054	broad.mit.edu	37	2	234191385	234191385	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr2:234191385G>A	uc002vty.2	+	12	1446	c.1189G>A	c.(1189-1191)GAT>AAT	p.D397N	ATG16L1_uc002vtx.1_Missense_Mutation_p.D234N|ATG16L1_uc002vua.2_Missense_Mutation_p.D378N|ATG16L1_uc002vub.2_Missense_Mutation_p.D255N|ATG16L1_uc002vtz.2_Missense_Mutation_p.D218N|ATG16L1_uc002vud.3_Missense_Mutation_p.D313N	NM_030803	NP_110430	Q676U5	A16L1_HUMAN	APG16 autophagy 16-like isoform 1	397	WD 2.				autophagic vacuole assembly|protein homooligomerization|protein transport	autophagic vacuole|pre-autophagosomal structure membrane	protein binding				0		Breast(86;0.0013)|Renal(207;0.00339)|all_hematologic(139;0.0116)|all_lung(227;0.0179)|Acute lymphoblastic leukemia(138;0.0327)|Lung NSC(271;0.0539)		Epithelial(121;1.53e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000379)|LUSC - Lung squamous cell carcinoma(224;0.00619)|Lung(119;0.00732)|GBM - Glioblastoma multiforme(43;0.11)		GACTGTGGATGATTATCGATT	0.413		NaN											0	0	0	0.008291	0	8	75									
PLCB1	23236	broad.mit.edu	37	20	8696958	8696958	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:8696958G>C	uc002wnb.2	+	13	1301	c.1298G>C	c.(1297-1299)GGG>GCG	p.G433A	PLCB1_uc010zrb.1_Missense_Mutation_p.G332A|PLCB1_uc002wna.2_Missense_Mutation_p.G433A|PLCB1_uc002wnc.1_Missense_Mutation_p.G332A|PLCB1_uc002wnd.1_Missense_Mutation_p.G10A	NM_015192	NP_056007	Q9NQ66	PLCB1_HUMAN	phosphoinositide-specific phospholipase C beta 1	433	PI-PLC X-box.				activation of meiosis involved in egg activation|CD24 biosynthetic process|cerebral cortex development|G1 phase|G2/M transition of mitotic cell cycle|glutamate signaling pathway|insulin-like growth factor receptor signaling pathway|interleukin-1-mediated signaling pathway|interleukin-12-mediated signaling pathway|interleukin-15-mediated signaling pathway|intracellular signal transduction|lipid catabolic process|memory|muscarinic acetylcholine receptor signaling pathway|negative regulation of monocyte extravasation|negative regulation of transcription, DNA-dependent|phosphatidylinositol metabolic process|positive regulation of acrosome reaction|positive regulation of developmental growth|positive regulation of embryonic development|positive regulation of interleukin-12 production|positive regulation of JNK cascade|positive regulation of myoblast differentiation|positive regulation of transcription, DNA-dependent|regulation of fertilization|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	cytosol|nuclear chromatin|nuclear speck	calcium ion binding|calmodulin binding|enzyme binding|GTPase activator activity|phosphatidylinositol phospholipase C activity|phosphatidylinositol-4,5-bisphosphate binding|protein homodimerization activity|signal transducer activity			ovary(4)|breast(3)|upper_aerodigestive_tract(2)|skin(2)|lung(1)	12						CTGATCTTTGGGGATGCCCTT	0.468		NaN											0	0	0	0.004482	0	8	40									
JAG1	182	broad.mit.edu	37	20	10620148	10620148	+	Nonstop_Mutation	SNP	A	A	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:10620148A>G	uc002wnw.2	-	26	4171	c.3655T>C	c.(3655-3657)TAG>CAG	p.*1219Q		NM_000214	NP_000205	P78504	JAG1_HUMAN	jagged 1 precursor	1219					angiogenesis|cell communication|cell fate determination|endothelial cell differentiation|hemopoiesis|keratinocyte differentiation|myoblast differentiation|Notch receptor processing|Notch signaling pathway|regulation of cell migration|regulation of cell proliferation	extracellular region|integral to plasma membrane	calcium ion binding|growth factor activity|Notch binding|structural molecule activity			lung(3)|ovary(2)|central_nervous_system(2)|breast(1)|pancreas(1)	9						GCGGTCTGCTATACGATGTAC	0.522		NaN							Alagille_Syndrome				0	0	0	0.008871	0	18	178									
CRNKL1	51340	broad.mit.edu	37	20	20022983	20022983	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:20022983C>T	uc002wrs.2	-	9	1665	c.1633G>A	c.(1633-1635)GAA>AAA	p.E545K		NM_016652	NP_057736	Q9BZJ0	CRNL1_HUMAN	crooked neck-like 1 protein	545					spliceosome assembly	catalytic step 2 spliceosome|cytoplasm|nuclear speck	RNA binding			ovary(2)|large_intestine(1)	3						GCCTCCAATTCTTCATAGAGT	0.413		NaN											0	0	0	0.008291	0	9	92									
MYH7B	57644	broad.mit.edu	37	20	33577919	33577919	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:33577919C>G	uc002xbi.1	+	19	2088	c.1996C>G	c.(1996-1998)CTC>GTC	p.L666V	MIR499_hsa-mir-499|MI0003183_5'Flank	NM_020884	NP_065935	A7E2Y1	MYH7B_HUMAN	myosin, heavy polypeptide 7B, cardiac muscle,	624	Myosin head-like.					membrane|myosin filament	actin binding|ATP binding|motor activity			ovary(1)|breast(1)	2			BRCA - Breast invasive adenocarcinoma(18;0.00691)			CCTGGCGACTCTCTATGAGAA	0.552		NaN											0	0	0	0.008291	0	11	134									
KIAA0406	9675	broad.mit.edu	37	20	36641489	36641489	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:36641489T>C	uc002xhl.2	-	3	939	c.730A>G	c.(730-732)AGC>GGC	p.S244G	KIAA0406_uc002xhm.2_Missense_Mutation_p.S244G	NM_014657	NP_055472	O43156	TTI1_HUMAN	hypothetical protein LOC9675	244							binding				0		Myeloproliferative disorder(115;0.00874)				ATAATGAAGCTCACTGTCTTG	0.443		NaN											0	0	0	0.00245	0	12	150									
SPINT4	391253	broad.mit.edu	37	20	44352659	44352659	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:44352659G>C	uc002xpe.1	+	2	275	c.256G>C	c.(256-258)GAA>CAA	p.E86Q		NM_178455	NP_848550	Q6UDR6	SPIT4_HUMAN	serine peptidase inhibitor, Kunitz type 4	86	BPTI/Kunitz inhibitor.					extracellular region	serine-type endopeptidase inhibitor activity			ovary(1)|lung(1)	2		Myeloproliferative disorder(115;0.028)				GCTTAAAATAGAACGTGAAGT	0.393		NaN											0	0	0	0.006214	0	7	122									
NCOA3	8202	broad.mit.edu	37	20	46279914	46279914	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:46279914C>T	uc002xtk.2	+	20	4045	c.3840C>T	c.(3838-3840)TTC>TTT	p.F1280F	NCOA3_uc010ght.1_Silent_p.F1271F|NCOA3_uc002xtl.2_Silent_p.F1276F|NCOA3_uc002xtm.2_Silent_p.F1275F|NCOA3_uc002xtn.2_Silent_p.F1279F|NCOA3_uc010zyc.1_Silent_p.F1075F	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	1280	Acetyltransferase.				androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						CCCAGGCCTTCAGCCCACCTC	0.308		NaN											0	0	0	0.009096	0	4	61									
ARFGEF2	10564	broad.mit.edu	37	20	47605103	47605103	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:47605103G>A	uc002xtx.3	+	18	2589	c.2437G>A	c.(2437-2439)GAG>AAG	p.E813K	ARFGEF2_uc010zyf.1_Missense_Mutation_p.E106K	NM_006420	NP_006411	Q9Y6D5	BIG2_HUMAN	ADP-ribosylation factor guanine	813					exocytosis|intracellular signal transduction|regulation of ARF protein signal transduction	cytosol|Golgi membrane	ARF guanyl-nucleotide exchange factor activity			breast(3)|upper_aerodigestive_tract(1)	4			BRCA - Breast invasive adenocarcinoma(12;0.00148)|Colorectal(8;0.198)			TCTGCCAGAAGAGTATCTCTC	0.313		NaN											0	0	0	0.00308	0	8	153									
PTGIS	5740	broad.mit.edu	37	20	48124546	48124546	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:48124546C>G	uc002xut.2	-	10	1468	c.1414G>C	c.(1414-1416)GAG>CAG	p.E472Q	PTGIS_uc010zyi.1_Missense_Mutation_p.E333Q	NM_000961	NP_000952	Q16647	PTGIS_HUMAN	prostaglandin I2 synthase	472					hormone biosynthetic process|prostaglandin biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum lumen|endoplasmic reticulum membrane|integral to membrane	electron carrier activity|heme binding|monooxygenase activity|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen|prostaglandin-I synthase activity			skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(12;2.37e-05)|COAD - Colon adenocarcinoma(4;0.14)|Colorectal(8;0.166)		Phenylbutazone(DB00812)	TCAGGGATCTCCACATCTGCG	0.572		NaN											0	0	0	0.008291	0	10	72									
SALL4	57167	broad.mit.edu	37	20	50401158	50401158	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:50401158C>G	uc002xwh.3	-	4	2909	c.2808G>C	c.(2806-2808)GAG>GAC	p.E936D	SALL4_uc010gii.2_Missense_Mutation_p.E499D|SALL4_uc002xwi.3_Missense_Mutation_p.E159D	NM_020436	NP_065169	Q9UJQ4	SALL4_HUMAN	sal-like 4	936					transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						CCATGGTGTTCTCGATGGCCA	0.493		NaN											0	0	0	0.004482	0	8	94									
ZFP64	55734	broad.mit.edu	37	20	50768754	50768754	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:50768754C>T	uc002xwl.2	-	6	2326	c.1977G>A	c.(1975-1977)CAG>CAA	p.Q659Q	ZFP64_uc002xwk.2_Intron|ZFP64_uc002xwm.2_Silent_p.Q657Q|ZFP64_uc002xwn.2_Silent_p.Q605Q	NM_018197	NP_060667	Q9NPA5	ZF64A_HUMAN	zinc finger protein 64 isoform a	659					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						TGGAGTAGGTCTGCTTGGGTA	0.547		NaN											0	0	0	0.001168	0	4	126									
TAF4	6874	broad.mit.edu	37	20	60578285	60578285	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:60578285G>A	uc002ybs.2	-	9	2417	c.2417C>T	c.(2416-2418)TCT>TTT	p.S806F		NM_003185	NP_003176	O00268	TAF4_HUMAN	TBP-associated factor 4	806					interspecies interaction between organisms|positive regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|pancreas(1)	3	Breast(26;1e-08)		BRCA - Breast invasive adenocarcinoma(19;3.1e-07)			CGAGACAGCAGAAAGGGCTTT	0.493		NaN											0	0	0	0.00308	0	7	111									
EEF1A2	1917	broad.mit.edu	37	20	62120317	62120317	+	Silent	SNP	C	C	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:62120317C>A	uc002yfd.1	-	6	1319	c.1218G>T	c.(1216-1218)CCG>CCT	p.P406P	EEF1A2_uc002yfe.1_Silent_p.P406P|EEF1A2_uc010gkg.1_Intron	NM_001958	NP_001949	Q05639	EF1A2_HUMAN	eukaryotic translation elongation factor 1 alpha	406						nucleus	GTP binding|GTPase activity|protein binding|translation elongation factor activity				0	all_cancers(38;9.45e-12)		BRCA - Breast invasive adenocarcinoma(10;1.22e-05)			TGGGCTTTCCCGGCACCATCT	0.647		NaN											1	0	6.40141e-05	0.010729	6.70305e-05	10	72									
TPD52L2	7165	broad.mit.edu	37	20	62500783	62500783	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:62500783G>C	uc002yhc.2	+	2	283	c.154G>C	c.(154-156)GAG>CAG	p.E52Q	TPD52L2_uc002ygy.2_Missense_Mutation_p.E52Q|TPD52L2_uc002ygz.2_Missense_Mutation_p.E52Q|TPD52L2_uc002yha.2_Missense_Mutation_p.E52Q|TPD52L2_uc002yhb.2_Missense_Mutation_p.E52Q|TPD52L2_uc002yhd.2_Missense_Mutation_p.E52Q|TPD52L2_uc011abk.1_Intron|TPD52L2_uc011abl.1_Missense_Mutation_p.E29Q	NM_003288	NP_003279	O43399	TPD54_HUMAN	tumor protein D52-like 2 isoform e	52	Potential.				regulation of cell proliferation	perinuclear region of cytoplasm	protein binding|protein homodimerization activity			ovary(1)|skin(1)	2	all_cancers(38;1.3e-12)|all_epithelial(29;2.23e-14)|Lung NSC(23;5.92e-10)|all_lung(23;2.08e-09)					GCTCAGGGCTGAGCTTACCAA	0.597		NaN											0	0	0	0.004482	0	6	78									
PRPF6	24148	broad.mit.edu	37	20	62659889	62659889	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:62659889A>T	uc002yho.2	+	18	2566	c.2398A>T	c.(2398-2400)ATG>TTG	p.M800L	PRPF6_uc002yhp.2_Missense_Mutation_p.M760L	NM_012469	NP_036601	O94906	PRP6_HUMAN	PRP6 pre-mRNA processing factor 6 homolog	800					assembly of spliceosomal tri-snRNP|positive regulation of transcription from RNA polymerase II promoter|spliceosome assembly	catalytic step 2 spliceosome|nucleoplasm|U4/U6 snRNP|U4/U6 x U5 tri-snRNP complex|U5 snRNP	androgen receptor binding|ribonucleoprotein binding|transcription coactivator activity			ovary(2)	2	all_cancers(38;6.47e-12)|all_epithelial(29;1.26e-13)|Lung NSC(23;9.37e-10)|all_lung(23;3.23e-09)					AAATACACTCATGGCCAAGGC	0.652		NaN											0	0	0	0.013537	0	11	122									
PCMTD2	55251	broad.mit.edu	37	20	62896743	62896743	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:62896743C>T	uc002yil.3	+	4	743	c.543C>T	c.(541-543)CTC>CTT	p.L181L	PCMTD2_uc002yim.3_Silent_p.L181L	NM_018257	NP_060727	Q9NV79	PCMD2_HUMAN	protein-L-isoaspartate (D-aspartate)	181						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity				0	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					AGAATCTTCTCAAAGTGGGAG	0.368		NaN											0	0	0	0.006214	0	8	107									
C21orf29	54084	broad.mit.edu	37	21	45950980	45950980	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr21:45950980C>T	uc002zfe.1	-	4	645	c.579G>A	c.(577-579)GTG>GTA	p.V193V	C21orf29_uc010gpv.1_Silent_p.V125V	NM_144991	NP_659428	Q8WU66	TSEAR_HUMAN	chromosome 21 open reading frame 29 precursor	193	TSP N-terminal.				cell adhesion	extracellular region	structural molecule activity				0						GAGCTCCTTTCACTGACAGGG	0.567		NaN											0	0	0	0.000602	0	4	44									
MRPL40	64976	broad.mit.edu	37	22	19422269	19422269	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr22:19422269C>T	uc002zpg.2	+	3	190	c.148C>T	c.(148-150)CTT>TTT	p.L50F	HIRA_uc010gro.1_Intron|HIRA_uc010grp.2_Intron|MRPL40_uc002zph.2_Missense_Mutation_p.L6F	NM_003776	NP_003767	Q9NQ50	RM40_HUMAN	mitochondrial ribosomal protein L40 precursor	50					anatomical structure morphogenesis	mitochondrial ribosome|nucleus					0	Colorectal(54;0.0993)					ATCAGAACCTCTTCGAAAAAA	0.383		NaN											0	0	0	0.004672	0	3	22									
GGT1	2678	broad.mit.edu	37	22	25023891	25023891	+	Silent	SNP	C	C	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr22:25023891C>A	uc003aan.1	+	13	1768	c.1281C>A	c.(1279-1281)CCC>CCA	p.P427P	GGT1_uc003aas.1_Silent_p.P427P|GGT1_uc003aat.1_Silent_p.P427P|GGT1_uc003aau.1_Silent_p.P427P|GGT1_uc003aav.1_Silent_p.P427P|GGT1_uc003aaw.1_Silent_p.P427P|GGT1_uc003aax.1_Silent_p.P427P|GGT1_uc003aay.1_Silent_p.P83P	NM_013430	NP_038347	P19440	GGT1_HUMAN	gamma-glutamyltransferase 1 precursor	427	Extracellular (Potential).				glutathione biosynthetic process	integral to membrane	acyltransferase activity|gamma-glutamyltransferase activity|protein binding				0					Glutathione(DB00143)	TCAGCTCTCCCAGCATCACCA	0.617		NaN											1	0	2.31682e-05	0.003163	2.43876e-05	12	201									
MYO18B	84700	broad.mit.edu	37	22	26286783	26286783	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr22:26286783G>A	uc003abz.1	+	26	4625	c.4375G>A	c.(4375-4377)GTG>ATG	p.V1459M	MYO18B_uc003aca.1_Missense_Mutation_p.V1340M|MYO18B_uc010guy.1_Missense_Mutation_p.V1341M|MYO18B_uc010guz.1_Missense_Mutation_p.V1340M|MYO18B_uc011aka.1_Missense_Mutation_p.V613M|MYO18B_uc011akb.1_Missense_Mutation_p.V972M	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	1459	Potential.|Tail.					nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						GGCCTGCCAGGTGCTGGAGAG	0.612		NaN											0	0	0	0.004482	0	7	37									
HPS4	89781	broad.mit.edu	37	22	26860092	26860092	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr22:26860092C>T	uc003acl.2	-	11	2163	c.1504G>A	c.(1504-1506)GCA>ACA	p.A502T	HPS4_uc003aci.2_Missense_Mutation_p.A497T|HPS4_uc003acj.2_Missense_Mutation_p.A366T|HPS4_uc003ack.2_Missense_Mutation_p.A293T|HPS4_uc003acn.2_Missense_Mutation_p.A348T|HPS4_uc010gvd.1_Missense_Mutation_p.A520T|HPS4_uc003ach.2_Missense_Mutation_p.A237T	NM_022081	NP_071364	Q9NQG7	HPS4_HUMAN	light ear protein isoform a	502					lysosome organization|positive regulation of eye pigmentation|protein stabilization|protein targeting	lysosome|melanosome|membrane fraction|platelet dense granule	protein homodimerization activity				0						CCAGGGGCTGCGTGGCTTTCA	0.567		NaN							Hermansky-Pudlak_syndrome				0	0	0	0.004878	0	27	148									
DRG1	4733	broad.mit.edu	37	22	31822752	31822752	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr22:31822752C>G	uc003aku.2	+	7	996	c.865C>G	c.(865-867)CTG>GTG	p.L289V		NM_004147	NP_004138	Q9Y295	DRG1_HUMAN	developmentally regulated GTP binding protein 1	289					multicellular organismal development|transcription, DNA-dependent	cytoplasm|intermediate filament cytoskeleton|nucleus	GTP binding|transcription factor binding			central_nervous_system(1)	1						CTGGGACTATCTGAAACTAGT	0.398		NaN											0	0	0	0.00499	0	13	104									
SSTR3	6753	broad.mit.edu	37	22	37603237	37603237	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr22:37603237C>T	uc003ara.2	-	2	668	c.606G>A	c.(604-606)TGG>TGA	p.W202*	SSTR3_uc003arb.2_Nonsense_Mutation_p.W202*	NM_001051	NP_001042	P32745	SSR3_HUMAN	somatostatin receptor 3	202	Extracellular (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|induction of apoptosis by hormones|negative regulation of cell proliferation	integral to plasma membrane|nonmotile primary cilium	somatostatin receptor activity			lung(1)	1						AGCCGGCTCGCCAGGCCGCCG	0.682		NaN											0	0	0	0.004672	0	3	16									
ELFN2	114794	broad.mit.edu	37	22	37771107	37771107	+	Silent	SNP	G	G	A	rs150477054		TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr22:37771107G>A	uc003asq.3	-	3	1254	c.468C>T	c.(466-468)ATC>ATT	p.I156I		NM_052906	NP_443138	Q5R3F8	LRFN6_HUMAN	leucine rich repeat containing 62	156	LRR 5.|Extracellular (Potential).					cell surface|integral to membrane				upper_aerodigestive_tract(1)|ovary(1)	2	Melanoma(58;0.0574)					AGGACAGGTCGATGCTGATGA	0.642		NaN											0	0	0	0.00308	0	7	86									
ENTHD1	150350	broad.mit.edu	37	22	40139965	40139965	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr22:40139965C>T	uc003ayg.2	-	7	1794	c.1543G>A	c.(1543-1545)GAG>AAG	p.E515K		NM_152512	NP_689725	Q8IYW4	ENTD1_HUMAN	ENTH domain containing 1	515										ovary(2)|skin(1)	3	Melanoma(58;0.0749)					GTGGAAAACTCCCCCCAGTGA	0.413		NaN											0	0	0	0.009096	0	4	38									
ACO2	50	broad.mit.edu	37	22	41911842	41911842	+	Silent	SNP	A	A	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr22:41911842A>T	uc003bac.2	+	6	778	c.756A>T	c.(754-756)GCA>GCT	p.A252A	ACO2_uc003bad.2_Silent_p.A252A	NM_001098	NP_001089	Q99798	ACON_HUMAN	aconitase 2, mitochondrial precursor	252					citrate metabolic process|tricarboxylic acid cycle	mitochondrial matrix|nucleus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron ion binding|isocitrate hydro-lyase (cis-aconitate-forming) activity			breast(2)|ovary(1)|lung(1)	4						TGAAGGTGGCAGGCATCCTCA	0.612		NaN											0	0	0	0.004482	0	9	72									
CRELD2	79174	broad.mit.edu	37	22	50318084	50318084	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr22:50318084G>A	uc003bja.2	+	8	984	c.849G>A	c.(847-849)AGG>AGA	p.R283R	CRELD2_uc010haj.2_Silent_p.R283R|CRELD2_uc010hal.2_Silent_p.R332R|CRELD2_uc010hak.2_Silent_p.R255R|CRELD2_uc010ham.2_Intron	NM_024324	NP_077300	Q6UXH1	CREL2_HUMAN	cysteine-rich with EGF-like domains 2 isoform b	283	FU 2.					endoplasmic reticulum|extracellular region	calcium ion binding				0		all_cancers(38;5.53e-07)|all_epithelial(38;3.84e-06)|all_lung(38;0.00208)|Breast(42;0.0104)|Lung NSC(38;0.0199)|Ovarian(80;0.0907)|Lung SC(80;0.236)		BRCA - Breast invasive adenocarcinoma(115;0.198)|LUAD - Lung adenocarcinoma(64;0.247)		GCTACGCGAGGGAGCACGGAC	0.597		NaN											0	0	0	0.000602	0	5	17									
SBF1	6305	broad.mit.edu	37	22	50898430	50898430	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr22:50898430C>G	uc003blh.2	-	26	3637	c.3442G>C	c.(3442-3444)GAG>CAG	p.E1148Q	SBF1_uc011arx.1_Missense_Mutation_p.E812Q	NM_002972	NP_002963	O95248	MTMR5_HUMAN	SET binding factor 1	1148	Myotubularin phosphatase.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		CGGAAGGGCTCAGACTTGGCC	0.662		NaN											0	0	0	0.004482	0	7	63									
CHL1	10752	broad.mit.edu	37	3	432754	432754	+	Silent	SNP	T	T	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:432754T>C	uc003bou.2	+	21	2926	c.2655T>C	c.(2653-2655)TTT>TTC	p.F885F	CHL1_uc003bot.2_Silent_p.F901F|CHL1_uc003bow.1_Silent_p.F885F|CHL1_uc011asi.1_Silent_p.F901F	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	885	Fibronectin type-III 3.|Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		TAGATGCCTTTAGTGAATTTC	0.383		NaN											0	0	0	0.004007	0	13	46									
CNTN6	27255	broad.mit.edu	37	3	1367618	1367618	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:1367618G>A	uc003boz.2	+	9	1333	c.1066G>A	c.(1066-1068)GAA>AAA	p.E356K	CNTN6_uc011asj.1_Missense_Mutation_p.E284K|CNTN6_uc003bpa.2_Missense_Mutation_p.E356K	NM_014461	NP_055276	Q9UQ52	CNTN6_HUMAN	contactin 6 precursor	356	Ig-like C2-type 4.				axon guidance|cell adhesion|central nervous system development|Notch signaling pathway	anchored to membrane|plasma membrane				skin(3)|lung(2)|breast(2)|pancreas(1)	8		all_cancers(2;0.000164)|all_epithelial(2;0.107)		Epithelial(13;0.000233)|all cancers(10;0.0013)|OV - Ovarian serous cystadenocarcinoma(96;0.0139)		AAAAAATGGTGAACGACTCAA	0.353		NaN											0	0	0	0.004672	0	3	56									
C3orf20	84077	broad.mit.edu	37	3	14798893	14798893	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:14798893G>A	uc003byy.2	+	13	2360	c.1956G>A	c.(1954-1956)GAG>GAA	p.E652E	C3orf20_uc003byz.2_Silent_p.E530E|C3orf20_uc003bza.2_Silent_p.E530E|C3orf20_uc003bzb.1_Silent_p.E153E|C3orf20_uc011avj.1_5'UTR	NM_032137	NP_115513	Q8ND61	CC020_HUMAN	hypothetical protein LOC84077	652						cytoplasm|integral to membrane				ovary(3)|skin(1)	4						AGGCCCGCGAGGGGCGCAGCC	0.667		NaN											0	0	0	0.004672	0	3	13									
SLC4A7	9497	broad.mit.edu	37	3	27436152	27436152	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:27436152G>A	uc003cdv.2	-	20	3018	c.2947C>T	c.(2947-2949)CAT>TAT	p.H983Y	SLC4A7_uc011awu.1_RNA|SLC4A7_uc011awv.1_RNA|SLC4A7_uc003cdu.3_Missense_Mutation_p.H864Y|SLC4A7_uc011aww.1_Missense_Mutation_p.H992Y|SLC4A7_uc011awx.1_Missense_Mutation_p.H979Y|SLC4A7_uc011awy.1_Missense_Mutation_p.H975Y|SLC4A7_uc011awz.1_RNA|SLC4A7_uc011axa.1_Missense_Mutation_p.H864Y|SLC4A7_uc011axb.1_Missense_Mutation_p.H979Y|SLC4A7_uc010hfl.2_Missense_Mutation_p.H533Y|SLC4A7_uc003cdw.2_Missense_Mutation_p.H859Y	NM_003615	NP_003606	Q9Y6M7	S4A7_HUMAN	solute carrier family 4, sodium bicarbonate	983	Extracellular (Potential).					apical plasma membrane|basolateral plasma membrane|integral to membrane|stereocilium	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|central_nervous_system(1)|skin(1)	5						CTGTTGACATGACTTATTGAC	0.443		NaN											0	0	0	0.00278	0	19	77									
EOMES	8320	broad.mit.edu	37	3	27763709	27763709	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:27763709C>T	uc003cdx.2	-	1	77	c.77G>A	c.(76-78)CGA>CAA	p.R26Q	EOMES_uc003cdy.3_Missense_Mutation_p.R26Q|EOMES_uc010hfn.2_Missense_Mutation_p.R26Q|EOMES_uc011axc.1_Intron	NM_005442	NP_005433	O95936	EOMES_HUMAN	eomesodermin	26					CD8-positive, alpha-beta T cell differentiation involved in immune response|cell differentiation involved in embryonic placenta development|endoderm formation|mesoderm formation|mesodermal to mesenchymal transition involved in gastrulation|positive regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|breast(1)	4						GCTGCCGCCTCGCGCACTCTC	0.637		NaN											0	0	0	0.009096	0	4	9									
ZNF35	7584	broad.mit.edu	37	3	44700638	44700638	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:44700638G>C	uc003cnq.2	+	4	1004	c.783G>C	c.(781-783)CAG>CAC	p.Q261H	ZNF35_uc003cnr.2_Missense_Mutation_p.Q101H	NM_003420	NP_003411	P13682	ZNF35_HUMAN	zinc finger protein 35	261	C2H2-type 2.				cellular response to retinoic acid|spermatogenesis	nucleus|perinuclear region of cytoplasm	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Ovarian(412;0.0228)		OV - Ovarian serous cystadenocarcinoma(275;2.49e-27)|KIRC - Kidney renal clear cell carcinoma(197;0.0475)|Kidney(197;0.0595)		CCTTCATTCAGAGTGCAAACC	0.458		NaN											0	0	0	0.004482	0	7	55									
LRRC2	79442	broad.mit.edu	37	3	46586552	46586552	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:46586552G>A	uc010hji.2	-	3	681	c.317C>T	c.(316-318)TCT>TTT	p.S106F	LRRC2_uc003cpu.3_Missense_Mutation_p.S106F	NM_024512	NP_078788	Q9BYS8	LRRC2_HUMAN	leucine rich repeat containing 2	106										ovary(1)	1		Ovarian(412;0.0563)		OV - Ovarian serous cystadenocarcinoma(275;6.37e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00133)|KIRC - Kidney renal clear cell carcinoma(197;0.0214)|Kidney(197;0.0254)		GTGCTCCCCAGAAAGTTCAAA	0.537		NaN											0	0	0	0.012213	0	26	276									
ALS2CL	259173	broad.mit.edu	37	3	46712990	46712990	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:46712990G>A	uc003cqa.1	-	25	2959	c.2769C>T	c.(2767-2769)CTC>CTT	p.L923L	ALS2CL_uc003cpx.1_Silent_p.L270L|ALS2CL_uc003cpy.1_RNA|ALS2CL_uc003cpz.1_Silent_p.L438L|ALS2CL_uc003cqb.1_Silent_p.L923L|ALS2CL_uc003cqc.1_RNA	NM_147129	NP_667340	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like isoform 1	923	VPS9.				endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(2)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		CCAGGGCTGTGAGCAGGAAGT	0.592		NaN											0	0	0	0.000602	0	5	68									
SETD2	29072	broad.mit.edu	37	3	47155366	47155366	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:47155366G>A	uc003cqs.2	-	5	4768	c.4715C>T	c.(4714-4716)TCG>TTG	p.S1572L	SETD2_uc003cqv.2_Missense_Mutation_p.S1561L	NM_014159	NP_054878	Q9BYW2	SETD2_HUMAN	SET domain containing 2	1572	SET.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	DNA binding|histone-lysine N-methyltransferase activity|oxidoreductase activity|transition metal ion binding			kidney(24)|ovary(5)|skin(1)|central_nervous_system(1)|breast(1)	32		Acute lymphoblastic leukemia(5;0.0169)		BRCA - Breast invasive adenocarcinoma(193;0.000302)|KIRC - Kidney renal clear cell carcinoma(197;0.00732)|Kidney(197;0.00844)		AAGAACTTACGAAGGAAGGTC	0.279		NaN	N|F|S|Mis		clear cell renal carcinoma								0	0	0	0.004672	0	3	56									
SMARCC1	6599	broad.mit.edu	37	3	47777526	47777526	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:47777526G>C	uc003crq.2	-	5	692	c.574C>G	c.(574-576)CAG>GAG	p.Q192E	SMARCC1_uc011bbd.1_Missense_Mutation_p.Q83E	NM_003074	NP_003065	Q92922	SMRC1_HUMAN	SWI/SNF-related matrix-associated	192					chromatin remodeling|nervous system development|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex|WINAC complex	DNA binding|protein N-terminus binding|transcription coactivator activity			skin(2)|lung(1)	3				BRCA - Breast invasive adenocarcinoma(193;7.47e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.00862)|Kidney(197;0.01)		TCTATTACCTGATGTCGTTTG	0.348		NaN											0	0	0	0.009096	0	3	58									
QRICH1	54870	broad.mit.edu	37	3	49114384	49114384	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:49114384G>A	uc010hkq.2	-	3	363	c.67C>T	c.(67-69)CCG>TCG	p.P23S	QRICH1_uc003cvu.2_Missense_Mutation_p.P23S|QRICH1_uc003cvv.2_Missense_Mutation_p.P23S	NM_198880	NP_942581	Q2TAL8	QRIC1_HUMAN	glutamine-rich 1	23	CARD.									ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.88e-05)|Kidney(197;0.00239)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)		CTGTGTTGCGGGACAGACCGT	0.488		NaN											0	0	0	0.004672	0	3	139									
APEH	327	broad.mit.edu	37	3	49716346	49716346	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:49716346G>A	uc003cxf.2	+	12	1522	c.1122G>A	c.(1120-1122)CAG>CAA	p.Q374Q	APEH_uc010hkw.1_Silent_p.Q374Q	NM_001640	NP_001631	P13798	ACPH_HUMAN	N-acylaminoacyl-peptide hydrolase	374					proteolysis	cytoplasm|nuclear membrane	serine-type endopeptidase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;4.53e-05)|Kidney(197;0.00218)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)		CTGACAGCCAGAGAGTGGTCT	0.602		NaN											0	0	0	0.004482	0	7	91									
SLC38A3	10991	broad.mit.edu	37	3	50252990	50252990	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:50252990G>A	uc003cyn.3	+	6	529	c.388G>A	c.(388-390)GAG>AAG	p.E130K	SLC38A3_uc011bdl.1_Missense_Mutation_p.E105K|SLC38A3_uc011bdm.1_Missense_Mutation_p.E61K	NM_006841	NP_006832	Q99624	S38A3_HUMAN	solute carrier family 38, member 3	130					cellular nitrogen compound metabolic process|sodium ion transport	integral to plasma membrane	antiporter activity|L-alanine transmembrane transporter activity|L-asparagine transmembrane transporter activity|L-glutamine transmembrane transporter activity|L-histidine transmembrane transporter activity|symporter activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000275)|KIRC - Kidney renal clear cell carcinoma(197;0.00548)|Kidney(197;0.00615)	L-Asparagine(DB00174)|L-Glutamine(DB00130)|L-Histidine(DB00117)	CCGTGCCTATGAGCAGCTGGG	0.627		NaN											0	0	0	0.000602	0	4	52									
IFRD2	7866	broad.mit.edu	37	3	50327428	50327428	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:50327428G>A	uc011bdp.1	-	5	799	c.670C>T	c.(670-672)CAC>TAC	p.H224Y	IFRD2_uc003czb.2_Missense_Mutation_p.H326Y	NM_006764	NP_006755	Q12894	IFRD2_HUMAN	interferon-related developmental regulator 2	224							binding			lung(2)|ovary(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.00544)|Kidney(197;0.00607)		TGCAGGCTGTGAAACAGCTCC	0.637		NaN											0	0	0	0.000602	0	5	14									
CISH	1154	broad.mit.edu	37	3	50645378	50645378	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:50645378G>A	uc003dax.2	-	3	618	c.437C>T	c.(436-438)TCC>TTC	p.S146F	CISH_uc010hlq.2_Missense_Mutation_p.S163F	NM_145071	NP_659508	Q9NSE2	CISH_HUMAN	cytokine-inducible SH2-containing protein	146	SH2.				intracellular signal transduction|negative regulation of signal transduction|regulation of cell growth	intracellular					0				BRCA - Breast invasive adenocarcinoma(193;0.000272)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		GCGTGGCCTGGACAAGCAGTT	0.582		NaN											0	0	0	0.004672	0	3	44									
RAD54L2	23132	broad.mit.edu	37	3	51664777	51664777	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:51664777G>A	uc011bdt.1	+	6	780	c.655G>A	c.(655-657)GAA>AAA	p.E219K	RAD54L2_uc003dbh.2_5'UTR|RAD54L2_uc011bdu.1_5'UTR|RAD54L2_uc003dbj.2_5'UTR	NM_015106	NP_055921	Q9Y4B4	ARIP4_HUMAN	RAD54-like 2	219						nucleus	ATP binding|DNA binding|helicase activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;0.000102)|Kidney(197;0.000758)|KIRC - Kidney renal clear cell carcinoma(197;0.000896)		GGACAGCAGTGAATCTGTCAG	0.488		NaN											0	0	0	0.001168	0	4	36									
PPM1M	132160	broad.mit.edu	37	3	52282434	52282434	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:52282434G>C	uc003ddf.3	+	6	761	c.396G>C	c.(394-396)CAG>CAC	p.Q132H	PPM1M_uc011bed.1_Missense_Mutation_p.Q293H|PPM1M_uc010hmd.2_Missense_Mutation_p.Q132H|PPM1M_uc003ddg.3_Missense_Mutation_p.Q81H|PPM1M_uc003ddh.3_5'Flank			Q96MI6	PPM1M_HUMAN	RecName: Full=Protein phosphatase 1M;          EC=3.1.3.16; AltName: Full=Protein phosphatase 2C isoform eta;          Short=PP2C-eta;          Short=PP2CE;	132	PP2C-like.				protein dephosphorylation	nucleus	CTD phosphatase activity|manganese ion binding				0				BRCA - Breast invasive adenocarcinoma(193;2.4e-05)|Kidney(197;0.00171)|KIRC - Kidney renal clear cell carcinoma(197;0.00194)		ACTTGGGACAGAAGGTTTTGT	0.612		NaN											0	0	0	0.009096	0	3	27									
ITIH3	3699	broad.mit.edu	37	3	52835027	52835027	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:52835027C>T	uc003dfv.2	+	11	1284	c.1248C>T	c.(1246-1248)ATC>ATT	p.I416I	ITIH3_uc011bek.1_Silent_p.I416I	NM_002217	NP_002208	Q06033	ITIH3_HUMAN	inter-alpha (globulin) inhibitor H3	416	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			ovary(2)|liver(1)	3				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		GGAATGCCATCGGGGGCAAGT	0.542		NaN											0	0	0	0.007291	0	25	172									
OR5K1	26339	broad.mit.edu	37	3	98189002	98189002	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:98189002C>T	uc003dsm.2	+	1	582	c.582C>T	c.(580-582)ATC>ATT	p.I194I		NM_001004736	NP_001004736	Q8NHB7	OR5K1_HUMAN	olfactory receptor, family 5, subfamily K,	194	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)	1						ATCCTTATATCAATGAACTGG	0.333		NaN											0	0	0	0.00245	0	14	159									
GUCA1C	9626	broad.mit.edu	37	3	108626914	108626914	+	Silent	SNP	G	G	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:108626914G>T	uc003dxj.2	-	4	653	c.585C>A	c.(583-585)TCC>TCA	p.S195S	GUCA1C_uc003dxk.2_3'UTR	NM_005459	NP_005450	O95843	GUC1C_HUMAN	guanylate cyclase activator 1C	195					signal transduction|visual perception		calcium ion binding|calcium sensitive guanylate cyclase activator activity				0						CAGGAGATTTGGAGGAGTCTG	0.453		NaN											1	0	7.03913e-09	0.013537	7.63739e-09	7	38									
PHLDB2	90102	broad.mit.edu	37	3	111603863	111603863	+	Silent	SNP	C	C	T	rs142557577		TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:111603863C>T	uc010hqa.2	+	2	1350	c.939C>T	c.(937-939)CCC>CCT	p.P313P	PHLDB2_uc003dyc.2_Silent_p.P340P|PHLDB2_uc003dyd.2_Silent_p.P313P|PHLDB2_uc003dyg.2_Silent_p.P313P|PHLDB2_uc003dyh.2_Silent_p.P313P|PHLDB2_uc003dye.3_Silent_p.P313P|PHLDB2_uc003dyf.3_Silent_p.P313P	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	313						cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						GGGCTTTACCCTATAAAACCT	0.448		NaN											0	0	0	0.001855	0	12	53									
UROC1	131669	broad.mit.edu	37	3	126208126	126208126	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:126208126G>A	uc003eiz.1	-	17	1733	c.1701C>T	c.(1699-1701)TTC>TTT	p.F567F	UROC1_uc010hsi.1_Silent_p.F627F	NM_144639	NP_653240	Q96N76	HUTU_HUMAN	urocanase domain containing 1 isoform 1	567					histidine catabolic process	cytosol	urocanate hydratase activity			ovary(1)	1				GBM - Glioblastoma multiforme(114;0.17)		CACCTGCACAGAAGGCAGAGC	0.468		NaN											0	0	0	0.003163	0	10	145									
AMOTL2	51421	broad.mit.edu	37	3	134085127	134085127	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:134085127C>G	uc003eqf.2	-	4	1475	c.1358G>C	c.(1357-1359)AGA>ACA	p.R453T	AMOTL2_uc003eqg.1_Missense_Mutation_p.R395T|AMOTL2_uc003eqh.1_Missense_Mutation_p.R395T|AMOTL2_uc003eqe.1_Missense_Mutation_p.R20T	NM_016201	NP_057285	Q9Y2J4	AMOL2_HUMAN	angiomotin like 2	395	Potential.									large_intestine(1)	1						GCTCTCACCTCTAAGATCCCG	0.498		NaN											0	0	0	0.01441	0	39	359									
EPHB1	2047	broad.mit.edu	37	3	134851765	134851765	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:134851765G>T	uc003eqt.2	+	5	1391	c.1171G>T	c.(1171-1173)GTC>TTC	p.V391F	EPHB1_uc010htz.1_RNA|EPHB1_uc011bly.1_3'UTR|EPHB1_uc003equ.2_5'UTR	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	391	Extracellular (Potential).|Fibronectin type-III 1.					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						GGAGTGCCGCGTCTCCATCAG	0.622		NaN											1	0	5.18039e-06	0.00308	5.51105e-06	7	39									
PRR23A	729627	broad.mit.edu	37	3	138724624	138724624	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:138724624C>T	uc011bms.1	-	1	487	c.487G>A	c.(487-489)GAG>AAG	p.E163K		NM_001134659	NP_001128131	A6NEV1	PR23A_HUMAN	proline rich 23A	163											0						TCCGGAAACTCGGGGTCCGCG	0.657		NaN											0	0	0	0.009096	0	4	20									
CPB1	1360	broad.mit.edu	37	3	148562481	148562481	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:148562481G>C	uc003ewl.2	+	8	728	c.705G>C	c.(703-705)AAG>AAC	p.K235N		NM_001871	NP_001862	P15086	CBPB1_HUMAN	pancreatic carboxypeptidase B1 preproprotein	235					proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3			LUSC - Lung squamous cell carcinoma(72;0.0934)|Lung(72;0.115)			TTTGGAGAAAGACTCGCTCCA	0.438		NaN											0	0	0	0.004482	0	7	105									
WWTR1	25937	broad.mit.edu	37	3	149245664	149245664	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:149245664C>T	uc003exe.2	-	4	880	c.864G>A	c.(862-864)ATG>ATA	p.M288I	WWTR1_uc003exf.2_Missense_Mutation_p.M288I|WWTR1_uc011bns.1_Missense_Mutation_p.M288I|WWTR1_uc003exh.2_Missense_Mutation_p.M288I	NM_015472	NP_056287	Q9GZV5	WWTR1_HUMAN	WW domain containing transcription regulator 1	288					hippo signaling cascade|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|negative regulation of protein kinase activity|negative regulation of protein phosphorylation|positive regulation of cell proliferation|positive regulation of epithelial to mesenchymal transition|regulation of SMAD protein import into nucleus|stem cell division|transcription, DNA-dependent	cytoplasm	transcription coactivator activity			breast(3)|skin(1)	4			LUSC - Lung squamous cell carcinoma(72;0.0378)|Lung(72;0.048)			TGATGGATCTCATGTCTGGGG	0.463		NaN											0	0	0	0.003163	0	14	201									
MED12L	116931	broad.mit.edu	37	3	150906195	150906195	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:150906195C>T	uc003eyp.2	+	12	1719	c.1681C>T	c.(1681-1683)CTT>TTT	p.L561F	MED12L_uc011bnz.1_Missense_Mutation_p.L421F|MED12L_uc003eyn.2_Missense_Mutation_p.L561F|MED12L_uc003eyo.2_Missense_Mutation_p.L561F	NM_053002	NP_443728	Q86YW9	MD12L_HUMAN	mediator of RNA polymerase II transcription,	561					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	mediator complex				ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			TTCATCCTCTCTTGCTGGATC	0.373		NaN											0	0	0	0.001984	0	5	66									
RAP2B	5912	broad.mit.edu	37	3	152880590	152880590	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:152880590C>T	uc003ezr.2	+	1	562	c.108C>T	c.(106-108)ATC>ATT	p.I36I		NM_002886	NP_002877	P61225	RAP2B_HUMAN	RAP2B, member of RAS oncogene family precursor	36	Effector region (Probable).				Rap protein signal transduction|regulation of protein tyrosine kinase activity	recycling endosome membrane	GTP binding|GTPase activity			lung(2)	2			LUSC - Lung squamous cell carcinoma(72;0.0628)|Lung(72;0.11)			ACCCGACCATCGAAGACTTTT	0.627		NaN											0	0	0	0.008291	0	9	117									
PTX3	5806	broad.mit.edu	37	3	157160451	157160451	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:157160451G>A	uc003fbl.3	+	3	972	c.829G>A	c.(829-831)GAG>AAG	p.E277K	VEPH1_uc003fbj.1_Intron|VEPH1_uc003fbk.1_Intron|VEPH1_uc010hvu.1_Intron	NM_002852	NP_002843	P26022	PTX3_HUMAN	pentraxin 3 precursor	277	Pentaxin.				inflammatory response	extracellular region				central_nervous_system(1)	1			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			CTGGAATTCAGAGGAAGGGCT	0.537		NaN											0	0	0	0.009096	0	3	71									
SI	6476	broad.mit.edu	37	3	164724636	164724636	+	Silent	SNP	G	G	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:164724636G>T	uc003fei.2	-	37	4436	c.4374C>A	c.(4372-4374)CTC>CTA	p.L1458L		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	1458	Sucrase.|Lumenal.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	ACCATCCATAGAGATTGTGAA	0.348		NaN								HNSCC(35;0.089)			1	0	0.00116845	0.001168	0.00119841	5	58									
BCHE	590	broad.mit.edu	37	3	165548711	165548711	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:165548711C>G	uc003fem.3	-	2	271	c.111G>C	c.(109-111)AAG>AAC	p.K37N	BCHE_uc003fen.3_Intron	NM_000055	NP_000046	P06276	CHLE_HUMAN	butyrylcholinesterase precursor	37					choline metabolic process|cocaine metabolic process|synaptic transmission, cholinergic	endoplasmic reticulum lumen|extracellular space|membrane	acetylcholinesterase activity|beta-amyloid binding|carboxylesterase activity|cholinesterase activity|enzyme binding			ovary(3)|pancreas(1)	4					Ambenonium(DB01122)|Atropine(DB00572)|Bambuterol(DB01408)|Chlorpromazine(DB00477)|Choline(DB00122)|Cinnarizine(DB00568)|Demecarium bromide(DB00944)|Dibucaine(DB00527)|Donepezil(DB00843)|Echothiophate Iodide(DB01057)|Edrophonium(DB01010)|Ethopropazine(DB00392)|Etomidate(DB00292)|Galantamine(DB00674)|Hexafluronium bromide(DB00941)|Isoflurophate(DB00677)|Mefloquine(DB00358)|Mivacurium(DB01226)|Neostigmine(DB01400)|Pancuronium(DB01337)|Pralidoxime(DB00733)|Procainamide(DB01035)|Pyridostigmine(DB00545)|Rivastigmine(DB00989)|Succinylcholine(DB00202)|Terbutaline(DB00871)|Trimethaphan(DB01116)	CTTTTCCATTCTTTGTTGCAA	0.408		NaN											0	0	0	0.000602	0	3	44									
NAALADL2	254827	broad.mit.edu	37	3	174951896	174951896	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:174951896C>T	uc003fit.2	+	3	808	c.721C>T	c.(721-723)CAT>TAT	p.H241Y	NAALADL2_uc003fiu.1_Missense_Mutation_p.H234Y|NAALADL2_uc010hwy.1_Missense_Mutation_p.H63Y	NM_207015	NP_996898	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	241	Extracellular (Potential).				proteolysis	integral to membrane	peptidase activity			pancreas(1)	1	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		TCAATGCTTTCATCCTAATGG	0.488		NaN											0	0	0	0.00278	0	22	102									
ZMAT3	64393	broad.mit.edu	37	3	178742989	178742989	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:178742989C>A	uc003fjg.2	-	6	945	c.686G>T	c.(685-687)CGG>CTG	p.R229L	ZMAT3_uc010hxa.2_Missense_Mutation_p.R228L|ZMAT3_uc003fji.2_Missense_Mutation_p.R228L	NM_022470	NP_071915	Q9HA38	ZMAT3_HUMAN	p53 target zinc finger protein isoform 1	229					apoptosis|protein transport|regulation of growth|response to DNA damage stimulus|transmembrane transport	nucleolus	RNA binding|zinc ion binding			ovary(2)	2	all_cancers(143;3.31e-18)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;6.74e-27)|GBM - Glioblastoma multiforme(14;0.00448)|BRCA - Breast invasive adenocarcinoma(182;0.0527)			AATTCTCTGCCGAGAGCGGGG	0.418		NaN											1	0	0.00024832	0.009096	0.000257326	4	22									
PEX5L	51555	broad.mit.edu	37	3	179597763	179597763	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:179597763C>T	uc003fki.1	-	5	589	c.459G>A	c.(457-459)CAG>CAA	p.Q153Q	PEX5L_uc011bqd.1_Silent_p.Q110Q|PEX5L_uc011bqe.1_5'UTR|PEX5L_uc011bqf.1_Intron|PEX5L_uc003fkj.1_Silent_p.Q118Q|PEX5L_uc010hxd.1_Silent_p.Q151Q|PEX5L_uc011bqg.1_Silent_p.Q129Q|PEX5L_uc011bqh.1_Silent_p.Q94Q	NM_016559	NP_057643	Q8IYB4	PEX5R_HUMAN	peroxisomal biogenesis factor 5-like	153					protein import into peroxisome matrix|regulation of cAMP-mediated signaling	cytosol|peroxisomal membrane	peroxisome matrix targeting signal-1 binding			ovary(3)|large_intestine(1)	4	all_cancers(143;3.94e-14)|Ovarian(172;0.0338)|Breast(254;0.183)		OV - Ovarian serous cystadenocarcinoma(80;1.75e-26)|GBM - Glioblastoma multiforme(14;0.000518)			GCTGGCCTCTCTGCTCAGCAT	0.512		NaN											0	0	0	0.013537	0	9	72									
B3GNT5	84002	broad.mit.edu	37	3	182987890	182987890	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:182987890G>A	uc003flk.2	+	2	834	c.304G>A	c.(304-306)GAT>AAT	p.D102N	MCF2L2_uc003fli.1_Intron|MCF2L2_uc003flj.1_Intron|MCF2L2_uc011bqr.1_Intron|B3GNT5_uc003fll.2_Missense_Mutation_p.D102N|B3GNT5_uc003flm.2_Missense_Mutation_p.D102N	NM_032047	NP_114436	Q9BYG0	B3GN5_HUMAN	UDP-GlcNAc:betaGal	102	Lumenal (Potential).				central nervous system development|glycolipid biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity|galactosyltransferase activity			ovary(1)	1	all_cancers(143;8.52e-13)|Ovarian(172;0.0355)		all cancers(12;4.52e-44)|Epithelial(37;8.82e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			TGAAAACTATGATCGACGTTC	0.438		NaN											0	0	0	0.000602	0	5	67									
B3GNT5	84002	broad.mit.edu	37	3	182988156	182988156	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:182988156G>C	uc003flk.2	+	2	1100	c.570G>C	c.(568-570)ATG>ATC	p.M190I	MCF2L2_uc003fli.1_Intron|MCF2L2_uc003flj.1_Intron|MCF2L2_uc011bqr.1_Intron|B3GNT5_uc003fll.2_Missense_Mutation_p.M190I|B3GNT5_uc003flm.2_Missense_Mutation_p.M190I	NM_032047	NP_114436	Q9BYG0	B3GN5_HUMAN	UDP-GlcNAc:betaGal	190	Lumenal (Potential).				central nervous system development|glycolipid biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity|galactosyltransferase activity			ovary(1)	1	all_cancers(143;8.52e-13)|Ovarian(172;0.0355)		all cancers(12;4.52e-44)|Epithelial(37;8.82e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			AATTTCTTATGACTGCTGATG	0.353		NaN											0	0	0	0.013537	0	12	152									
B3GNT5	84002	broad.mit.edu	37	3	182988310	182988310	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:182988310G>A	uc003flk.2	+	2	1254	c.724G>A	c.(724-726)GAA>AAA	p.E242K	MCF2L2_uc003fli.1_Intron|MCF2L2_uc003flj.1_Intron|MCF2L2_uc011bqr.1_Intron|B3GNT5_uc003fll.2_Missense_Mutation_p.E242K|B3GNT5_uc003flm.2_Missense_Mutation_p.E242K	NM_032047	NP_114436	Q9BYG0	B3GN5_HUMAN	UDP-GlcNAc:betaGal	242	Lumenal (Potential).				central nervous system development|glycolipid biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity|galactosyltransferase activity			ovary(1)	1	all_cancers(143;8.52e-13)|Ovarian(172;0.0355)		all cancers(12;4.52e-44)|Epithelial(37;8.82e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			CGTGTCCTATGAAATGTACCA	0.463		NaN											0	0	0	0.001168	0	5	88									
B3GNT5	84002	broad.mit.edu	37	3	182988588	182988588	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:182988588G>C	uc003flk.2	+	2	1532	c.1002G>C	c.(1000-1002)AAG>AAC	p.K334N	MCF2L2_uc003fli.1_Intron|MCF2L2_uc003flj.1_Intron|MCF2L2_uc011bqr.1_Intron|B3GNT5_uc003fll.2_Missense_Mutation_p.K334N|B3GNT5_uc003flm.2_Missense_Mutation_p.K334N	NM_032047	NP_114436	Q9BYG0	B3GN5_HUMAN	UDP-GlcNAc:betaGal	334	Lumenal (Potential).				central nervous system development|glycolipid biosynthetic process|protein glycosylation	Golgi membrane|integral to membrane	beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity|galactosyltransferase activity			ovary(1)	1	all_cancers(143;8.52e-13)|Ovarian(172;0.0355)		all cancers(12;4.52e-44)|Epithelial(37;8.82e-38)|LUSC - Lung squamous cell carcinoma(7;7.12e-25)|Lung(8;6.39e-23)|OV - Ovarian serous cystadenocarcinoma(80;6.75e-21)			ACCTTTGGAAGAATGCTACAG	0.343		NaN											0	0	0	0.000602	0	4	33									
AHSG	197	broad.mit.edu	37	3	186331033	186331033	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:186331033C>T	uc003fqk.3	+	1	184	c.103C>T	c.(103-105)CCA>TCA	p.P35S	AHSG_uc003fqj.2_Missense_Mutation_p.P35S|AHSG_uc003fql.3_Missense_Mutation_p.P35S|AHSG_uc003fqm.3_Missense_Mutation_p.P35S|AHSG_uc010hyp.2_Missense_Mutation_p.P35S	NM_001622	NP_001613	P02765	FETUA_HUMAN	alpha-2-HS-glycoprotein	35	Cystatin fetuin-A-type 1.				acute-phase response|negative regulation of bone mineralization|negative regulation of insulin receptor signaling pathway|pinocytosis|positive regulation of phagocytosis|regulation of inflammatory response|skeletal system development	extracellular space	cysteine-type endopeptidase inhibitor activity|protein binding				0	all_cancers(143;3.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;3.27e-20)	GBM - Glioblastoma multiforme(93;0.0463)		CTGCGATGATCCAGAAACTGA	0.502		NaN											0	0	0	0.001984	0	7	53									
KIAA1530	57654	broad.mit.edu	37	4	1347046	1347046	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:1347046C>T	uc003gde.3	+	5	1226	c.779C>T	c.(778-780)TCT>TTT	p.S260F		NM_020894	NP_065945	Q2YD98	K1530_HUMAN	hypothetical protein LOC57654	260											0			OV - Ovarian serous cystadenocarcinoma(23;0.0138)			CTGCCTGCCTCTGCAGGCCAC	0.706		NaN											0	0	0	0.004672	0	3	17									
WHSC1	7468	broad.mit.edu	37	4	1957023	1957023	+	Missense_Mutation	SNP	A	A	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:1957023A>C	uc003gdz.3	+	13	2650	c.2474A>C	c.(2473-2475)CAC>CCC	p.H825P	WHSC1_uc003geb.3_Missense_Mutation_p.H825P|WHSC1_uc003gec.3_Missense_Mutation_p.H825P|WHSC1_uc003ged.3_Missense_Mutation_p.H825P|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gei.3_Missense_Mutation_p.H44P|WHSC1_uc011bvh.1_5'UTR|WHSC1_uc010icf.2_Missense_Mutation_p.H173P	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	825					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		GGGAAGCGACACCACGCCCAC	0.612		NaN	T	IGH@	MM								0	0	0	0.013537	0	10	40									
SEL1L3	23231	broad.mit.edu	37	4	25849234	25849234	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:25849234G>A	uc003gru.3	-	2	567	c.415C>T	c.(415-417)CAC>TAC	p.H139Y		NM_015187	NP_056002	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3	139						integral to membrane	binding				0						CTGCTGGTGTGAAGATGTTTC	0.388		NaN											0	0	0	0.001168	0	5	41									
ARAP2	116984	broad.mit.edu	37	4	36212143	36212143	+	Silent	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:36212143C>G	uc003gsq.1	-	6	1694	c.1356G>C	c.(1354-1356)CCG>CCC	p.P452P	ARAP2_uc003gsr.1_Silent_p.P452P	NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	452					regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						TTGAGCTTAACGGATAACTGT	0.383		NaN											0	0	0	0.006214	0	7	67									
TBC1D1	23216	broad.mit.edu	37	4	38037247	38037247	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:38037247G>C	uc003gtb.2	+	8	1684	c.1341G>C	c.(1339-1341)TTG>TTC	p.L447F	TBC1D1_uc011byd.1_Missense_Mutation_p.L447F|TBC1D1_uc010ifd.2_Missense_Mutation_p.L194F|TBC1D1_uc011byf.1_Missense_Mutation_p.L318F	NM_015173	NP_055988	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family,	447						nucleus	Rab GTPase activator activity			ovary(1)	1						AGAATGAATTGATTATTTCTT	0.333		NaN											0	0	0	0.006214	0	8	36									
WDR19	57728	broad.mit.edu	37	4	39254832	39254832	+	Silent	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:39254832G>C	uc003gtv.2	+	25	2950	c.2796G>C	c.(2794-2796)CTG>CTC	p.L932L	WDR19_uc011byi.1_Silent_p.L772L|WDR19_uc003gtw.1_Silent_p.L529L	NM_025132	NP_079408	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	932					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						GCATCTATCTGGATCACCTCA	0.348		NaN											0	0	0	0.006214	0	8	56									
GABRA2	2555	broad.mit.edu	37	4	46390673	46390673	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:46390673G>A	uc003gxc.3	-	1	724	c.51C>T	c.(49-51)TTC>TTT	p.F17F	GABRA2_uc010igc.2_Silent_p.F17F|GABRA2_uc011bzc.1_5'UTR|GABRA2_uc003gxe.2_Silent_p.F17F|GABRA2_uc010igd.1_Silent_p.F17F	NM_001114175	NP_001107647	P47869	GBRA2_HUMAN	gamma-aminobutyric acid A receptor, alpha 2	17					gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|skin(2)	4					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	CCCACACCAAGAAAACAAAAA	0.363		NaN											0	0	0	0.013537	0	9	120									
GABRA4	2557	broad.mit.edu	37	4	46973161	46973161	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:46973161C>T	uc003gxg.2	-	7	952	c.813G>A	c.(811-813)GTG>GTA	p.V271V		NM_000809	NP_000800	P48169	GBRA4_HUMAN	gamma-aminobutyric acid A receptor, alpha 4	271	Helical; (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|upper_aerodigestive_tract(1)|breast(1)	4					Alprazolam(DB00404)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	GAGAAAGAATCACTGTCATAA	0.363		NaN											0	0	0	0.004482	0	9	32									
EPHA5	2044	broad.mit.edu	37	4	66280023	66280023	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:66280023C>T	uc003hcy.2	-	7	1859	c.1666G>A	c.(1666-1668)GAG>AAG	p.E556K	EPHA5_uc003hcx.2_Missense_Mutation_p.E487K|EPHA5_uc003hcz.2_Missense_Mutation_p.E556K|EPHA5_uc011cah.1_Missense_Mutation_p.E556K|EPHA5_uc011cai.1_Missense_Mutation_p.E556K|EPHA5_uc003hda.2_Missense_Mutation_p.E556K	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	556	Extracellular (Potential).|Fibronectin type-III 2.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						GTTTCAAACTCAAATCTTCGA	0.438		NaN								TSP Lung(17;0.13)			0	0	0	0.003163	0	9	74									
YTHDC1	91746	broad.mit.edu	37	4	69188522	69188522	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:69188522G>A	uc003hdx.2	-	11	1899	c.1546C>T	c.(1546-1548)CAG>TAG	p.Q516*	YTHDC1_uc003hdy.2_Nonsense_Mutation_p.Q498*	NM_001031732	NP_001026902	Q96MU7	YTDC1_HUMAN	splicing factor YT521-B isoform 1	516	Arg-rich.									upper_aerodigestive_tract(1)|ovary(1)	2						GATCGGGGCTGAGAATGCATT	0.463		NaN											0	0	0	0.010729	0	12	69									
UGT2B10	7365	broad.mit.edu	37	4	69874575	69874575	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:69874575G>T	uc011cao.1	-	8	1332	c.1196C>A	c.(1195-1197)TCA>TAA	p.S399*	UGT2B10_uc011can.1_Nonsense_Mutation_p.S315*			P36537	UDB10_HUMAN	RecName: Full=UDP-glucuronosyltransferase 2B28;          Short=UDPGT 2B28;          EC=2.4.1.17; Flags: Precursor;	436					lipid metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(3)|ovary(2)	5						TTCTACTCACGAAGGATCATT	0.368		NaN											1	0	5.82388e-19	0.01441	6.43523e-19	45	105									
MUC7	4589	broad.mit.edu	37	4	71339777	71339777	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:71339777G>A	uc011cat.1	+	3	327	c.39G>A	c.(37-39)CTG>CTA	p.L13L	MUC7_uc011cau.1_Silent_p.L13L|MUC7_uc003hfj.2_Silent_p.L13L	NM_001145006	NP_001138478	Q8TAX7	MUC7_HUMAN	mucin 7, secreted precursor	13						extracellular region	protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4			Lung(101;0.211)			TCTGTGCACTGAGTGCTTGCT	0.373		NaN											0	0	0	0.010729	0	9	68									
MUC7	4589	broad.mit.edu	37	4	71347324	71347324	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:71347324C>T	uc011cat.1	+	4	1151	c.863C>T	c.(862-864)TCT>TTT	p.S288F	MUC7_uc011cau.1_Missense_Mutation_p.S288F|MUC7_uc003hfj.2_Missense_Mutation_p.S288F|uc011cav.1_RNA	NM_001145006	NP_001138478	Q8TAX7	MUC7_HUMAN	mucin 7, secreted precursor	288	6.|Thr-rich.					extracellular region	protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4			Lung(101;0.211)			CCCACACCTTCTGCAACTACA	0.577		NaN											0	0	0	0.004878	0	30	232									
GC	2638	broad.mit.edu	37	4	72623791	72623791	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:72623791C>T	uc003hge.2	-	7	952	c.799G>A	c.(799-801)GAG>AAG	p.E267K	GC_uc003hgd.2_Missense_Mutation_p.E145K|GC_uc010iie.2_Missense_Mutation_p.E267K|GC_uc010iif.2_Missense_Mutation_p.E286K	NM_000583	NP_000574	P02774	VTDB_HUMAN	vitamin D-binding protein precursor	267	Albumin 2.				hormone biosynthetic process|vitamin D metabolic process	cytosol|lysosomal lumen	actin binding|vitamin D binding|vitamin transporter activity			ovary(2)|upper_aerodigestive_tract(1)	3		all_hematologic(202;0.107)	Lung(101;0.148)		Cholecalciferol(DB00169)	GAGGCAGACTCACAGCATTTG	0.338		NaN											0	0	0	0.013537	0	13	77									
CDKL2	8999	broad.mit.edu	37	4	76523333	76523333	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:76523333T>A	uc003hiq.2	-	8	1473	c.948A>T	c.(946-948)AAA>AAT	p.K316N	CDKL2_uc011cbp.1_Missense_Mutation_p.K316N|CDKL2_uc010iix.1_RNA	NM_003948	NP_003939	Q92772	CDKL2_HUMAN	cyclin-dependent kinase-like 2	316					sex differentiation|signal transduction	cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			ovary(2)|stomach(2)|breast(2)|skin(1)	7			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			TGTTTTGGGATTTTTTAGATA	0.274		NaN											0	0	0	0.00308	0	4	38									
G3BP2	9908	broad.mit.edu	37	4	76572312	76572312	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:76572312C>G	uc003hir.2	-	10	1123	c.958G>C	c.(958-960)GAC>CAC	p.D320H	G3BP2_uc003his.2_Missense_Mutation_p.D320H|G3BP2_uc003hit.2_Missense_Mutation_p.D287H	NM_012297	NP_036429	Q9UN86	G3BP2_HUMAN	Ras-GTPase activating protein SH3 domain-binding	320					cytoplasmic sequestering of NF-kappaB|mRNA transport|Ras protein signal transduction|regulation of small GTPase mediated signal transduction	cytosol	GTPase activator activity|nucleotide binding|receptor signaling complex scaffold activity|RNA binding			breast(2)|central_nervous_system(1)	3			Lung(101;0.0973)|LUSC - Lung squamous cell carcinoma(112;0.122)			CTACGGTTGTCAGAGTCATTC	0.343		NaN											0	0	0	0.004007	0	12	105									
SHROOM3	57619	broad.mit.edu	37	4	77691979	77691979	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:77691979C>T	uc011cbx.1	+	10	6503	c.5550C>T	c.(5548-5550)TCC>TCT	p.S1850S	SHROOM3_uc003hkg.2_Silent_p.S1628S	NM_020859	NP_065910	Q8TF72	SHRM3_HUMAN	shroom family member 3 protein	1850	ASD2.				apical protein localization|cell morphogenesis|cellular pigment accumulation|pattern specification process|regulation of cell shape	adherens junction|apical junction complex|apical plasma membrane|cytoplasm|microtubule	actin binding			skin(2)|ovary(1)	3			Lung(101;0.0903)			TGCTGCTCTCCCTCTCGGGGC	0.522		NaN											0	0	0	0.004656	0	24	103									
WDFY3	23001	broad.mit.edu	37	4	85638082	85638082	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:85638082G>C	uc003hpd.2	-	49	8250	c.7842C>G	c.(7840-7842)ATC>ATG	p.I2614M	WDFY3_uc003hpe.1_Missense_Mutation_p.I225M	NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	WD repeat and FYVE domain containing 3 isoform	2614						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			ovary(2)|central_nervous_system(1)	3		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		GAACTTCCTTGATATCTTCAT	0.368		NaN											0	0	0	0.004289	0	27	117									
MTTP	4547	broad.mit.edu	37	4	100530103	100530103	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:100530103C>G	uc003hvc.3	+	13	1994	c.1738C>G	c.(1738-1740)CAA>GAA	p.Q580E	MTTP_uc011cej.1_Missense_Mutation_p.Q607E	NM_000253	NP_000244	P55157	MTP_HUMAN	microsomal triglyceride transfer protein large	580	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	CGCCATTGTTCAAGACATCCT	0.403		NaN											0	0	0	0.003954	0	20	100									
CASP6	839	broad.mit.edu	37	4	110612078	110612078	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:110612078C>T	uc003hzn.1	-	6	649	c.571G>A	c.(571-573)GAG>AAG	p.E191K	CASP6_uc003hzo.1_Missense_Mutation_p.E102K	NM_001226	NP_001217	P55212	CASP6_HUMAN	caspase 6 isoform alpha preproprotein	191					cellular component disassembly involved in apoptosis|induction of apoptosis|proteolysis	cytosol|nucleoplasm	cysteine-type endopeptidase activity|protein binding			ovary(1)|breast(1)	2		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000171)		GCATCCACCTCAGTTATGTTG	0.468		NaN											0	0	0	0.006122	0	15	80									
EGF	1950	broad.mit.edu	37	4	110864425	110864425	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:110864425G>C	uc003hzy.3	+	3	795	c.343G>C	c.(343-345)GAG>CAG	p.E115Q	EGF_uc011cfu.1_Missense_Mutation_p.E115Q|EGF_uc011cfv.1_Missense_Mutation_p.E115Q	NM_001963	NP_001954	P01133	EGF_HUMAN	epidermal growth factor precursor	115	LDL-receptor class B 1.|Extracellular (Potential).				angiogenesis|DNA replication|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of secretion|platelet activation|platelet degranulation|positive regulation of catenin import into nucleus|positive regulation of epidermal growth factor receptor activity|positive regulation of MAP kinase activity|positive regulation of mitosis|regulation of calcium ion import|regulation of protein localization at cell surface	integral to membrane|plasma membrane|platelet alpha granule lumen	calcium ion binding|epidermal growth factor receptor binding|growth factor activity|transmembrane receptor protein tyrosine kinase activator activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Hepatocellular(203;0.0893)		OV - Ovarian serous cystadenocarcinoma(123;9.87e-06)	Sulindac(DB00605)	ATGTAATATAGAGAAAAATGT	0.249		NaN											0	0	0	0.00308	0	8	69									
C4orf21	55345	broad.mit.edu	37	4	113524748	113524748	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:113524748C>T	uc003iau.2	-	10	3119	c.2908G>A	c.(2908-2910)GAG>AAG	p.E970K	C4orf21_uc003iaw.2_Missense_Mutation_p.E970K	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	Error:Variant_position_missing_in_Q6ZU11_after_alignment						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		TTTTCATACTCAGTGCTATCT	0.403		NaN											0	0	0	0.004007	0	12	72									
FAT4	79633	broad.mit.edu	37	4	126371442	126371442	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:126371442C>T	uc003ifj.3	+	9	9271	c.9271C>T	c.(9271-9273)CAA>TAA	p.Q3091*	FAT4_uc011cgp.1_Nonsense_Mutation_p.Q1389*|FAT4_uc003ifi.1_Nonsense_Mutation_p.Q569*	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	3091	Cadherin 30.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						TGAATTCTCTCAAAGCCACAT	0.458		NaN											0	0	0	0.004482	0	7	47									
HSPA4L	22824	broad.mit.edu	37	4	128722376	128722376	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:128722376G>A	uc003ifm.2	+	5	766	c.513G>A	c.(511-513)ATG>ATA	p.M171I	HSPA4L_uc010iny.1_Missense_Mutation_p.M130I|HSPA4L_uc011cgr.1_Missense_Mutation_p.M138I	NM_014278	NP_055093	O95757	HS74L_HUMAN	heat shock 70kDa protein 4-like	171					protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4						TAAGGTTGATGAATGAAACTA	0.328		NaN											0	0	0	0.008291	0	8	34									
DCHS2	54798	broad.mit.edu	37	4	155157962	155157962	+	Silent	SNP	G	G	T	rs138701263	byFrequency	TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:155157962G>T	uc003inw.2	-	25	6477	c.6477C>A	c.(6475-6477)GTC>GTA	p.V2159V		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	2159	Cadherin 19.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CAAGATAACCGACTTGCTTAT	0.403		NaN											1	0	0.000442599	0.006214	0.000456288	8	53									
IRF2	3660	broad.mit.edu	37	4	185340623	185340623	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:185340623C>T	uc003iwf.3	-	3	387	c.187G>A	c.(187-189)GGA>AGA	p.G63R		NM_002199	NP_002190	P14316	IRF2_HUMAN	interferon regulatory factor 2	63	IRF tryptophan pentad repeat.				blood coagulation|cell proliferation|interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	focal adhesion|nucleoplasm	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		all_lung(41;7.86e-14)|Lung NSC(41;1.87e-13)|Colorectal(36;0.00146)|Hepatocellular(41;0.00826)|Renal(120;0.00992)|Prostate(90;0.0115)|all_neural(102;0.0573)|all_hematologic(60;0.0592)		all cancers(43;3.94e-27)|Epithelial(43;5.3e-24)|OV - Ovarian serous cystadenocarcinoma(60;1.06e-10)|Colorectal(24;7.98e-07)|STAD - Stomach adenocarcinoma(60;3.95e-05)|GBM - Glioblastoma multiforme(59;8.3e-05)|COAD - Colon adenocarcinoma(29;0.000106)|BRCA - Breast invasive adenocarcinoma(30;0.000311)|LUSC - Lung squamous cell carcinoma(40;0.0128)|READ - Rectum adenocarcinoma(43;0.0419)		GTTTTAGTACCTGTATGGATT	0.433		NaN											0	0	0	0.003271	0	26	92									
KIAA1430	57587	broad.mit.edu	37	4	186111383	186111383	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:186111383G>A	uc003ixf.3	-	2	1115	c.968C>T	c.(967-969)TCG>TTG	p.S323L	KIAA1430_uc003ixg.2_Missense_Mutation_p.S323L	NM_020827	NP_065878	Q9P2B7	K1430_HUMAN	hypothetical protein LOC57587	323											0		all_lung(41;1.19e-13)|Lung NSC(41;3.16e-13)|Hepatocellular(41;0.00826)|Colorectal(36;0.00872)|Renal(120;0.00988)|Prostate(90;0.0235)|all_hematologic(60;0.0592)|all_neural(102;0.243)		all cancers(43;9.44e-26)|Epithelial(43;2.64e-23)|OV - Ovarian serous cystadenocarcinoma(60;1.66e-11)|Colorectal(24;6.03e-05)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.000331)|COAD - Colon adenocarcinoma(29;0.000427)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00924)|READ - Rectum adenocarcinoma(43;0.165)		CACTGAAGACGACTTTGAGGA	0.338		NaN											0	0	0	0.009096	0	4	25									
SLC12A7	10723	broad.mit.edu	37	5	1076861	1076861	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:1076861C>T	uc003jbu.2	-	13	1762	c.1696G>A	c.(1696-1698)GAG>AAG	p.E566K		NM_006598	NP_006589	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride	566	Helical; (Potential).				potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			skin(2)|large_intestine(1)|ovary(1)	4	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	ATGCCAGTCTCGCAGATGAGG	0.652		NaN											0	0	0	0.001984	0	6	77									
ADAMTS16	170690	broad.mit.edu	37	5	5239387	5239387	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:5239387C>T	uc003jdl.2	+	15	2416	c.2278C>T	c.(2278-2280)CAG>TAG	p.Q760*	ADAMTS16_uc003jdk.1_Nonsense_Mutation_p.Q760*|ADAMTS16_uc010itk.1_RNA	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	760	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						CCACACCAACCGTGAGTACTT	0.512		NaN											0	0	0	0.00499	0	16	120									
ADAMTS16	170690	broad.mit.edu	37	5	5239993	5239993	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:5239993G>A	uc003jdl.2	+	16	2616	c.2478G>A	c.(2476-2478)GAG>GAA	p.E826E	ADAMTS16_uc003jdk.1_Silent_p.E826E	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1	826	Spacer.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						ATGAGCCCGAGAACTTAATCG	0.517		NaN											0	0	0	0.00308	0	7	138									
DNAH5	1767	broad.mit.edu	37	5	13735275	13735275	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:13735275C>T	uc003jfd.2	-	68	11768	c.11726G>A	c.(11725-11727)CGA>CAA	p.R3909Q	DNAH5_uc003jfc.2_Missense_Mutation_p.R77Q	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3909					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					ATGCTTGACTCGGTTCCTCTG	0.438		NaN							Kartagener_syndrome				0	0	0	0.010729	0	8	110									
TRIO	7204	broad.mit.edu	37	5	14304625	14304625	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:14304625C>T	uc003jff.2	+	8	1430	c.1424C>T	c.(1423-1425)TCA>TTA	p.S475L	TRIO_uc003jfg.2_RNA|TRIO_uc011cna.1_Missense_Mutation_p.S426L|TRIO_uc003jfh.1_Missense_Mutation_p.S124L	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	475					apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity			skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					GACCTTCCCTCAGAGCTGCAG	0.393		NaN											0	0	0	0.010729	0	10	186									
NPR3	4883	broad.mit.edu	37	5	32712174	32712174	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:32712174C>T	uc003jhv.2	+	1	510	c.292C>T	c.(292-294)CGC>TGC	p.R98C	NPR3_uc010iuo.2_Intron|NPR3_uc011cnz.1_Intron|NPR3_uc003jhu.2_Missense_Mutation_p.R98C	NM_000908	NP_000899	P17342	ANPRC_HUMAN	natriuretic peptide receptor C/guanylate cyclase	98	Extracellular (Potential).				osteoclast proliferation|positive regulation of urine volume|regulation of blood pressure|regulation of osteoblast proliferation|skeletal system development	integral to membrane	hormone binding|natriuretic peptide receptor activity			ovary(1)|central_nervous_system(1)	2					Nesiritide(DB04899)	GCCGGGCACTCGCTTCCAGGT	0.662		NaN											0	0	0	0.009096	0	3	46									
BRIX1	55299	broad.mit.edu	37	5	34924954	34924954	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:34924954C>T	uc003jja.2	+	9	690	c.666C>T	c.(664-666)ATC>ATT	p.I222I		NM_018321	NP_060791	Q8TDN6	BRX1_HUMAN	BRIX	222	Brix.				ribosome biogenesis|translation	nucleolus	aminoacyl-tRNA ligase activity|ATP binding|protein binding				0						TATTAAAGATCATAGAAGAAG	0.323		NaN											0	0	0	0.009096	0	3	48									
C5orf42	65250	broad.mit.edu	37	5	37180226	37180226	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:37180226G>A	uc011cpa.1	-	28	5861	c.5630C>T	c.(5629-5631)TCC>TTC	p.S1877F	C5orf42_uc011coy.1_Missense_Mutation_p.S377F|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Missense_Mutation_p.S952F	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	1877										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			ATGAGTGATGGAAATAATATC	0.284		NaN											0	0	0	0.004672	0	3	55									
PARP8	79668	broad.mit.edu	37	5	49963917	49963917	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:49963917C>T	uc003jon.3	+	3	286	c.104C>T	c.(103-105)TCT>TTT	p.S35F	PARP8_uc011cpz.1_5'UTR|PARP8_uc003joo.2_Missense_Mutation_p.S35F|PARP8_uc003jop.2_Missense_Mutation_p.S35F	NM_024615	NP_078891	Q8N3A8	PARP8_HUMAN	poly (ADP-ribose) polymerase family, member 8	35						intracellular	NAD+ ADP-ribosyltransferase activity			lung(3)|large_intestine(1)|ovary(1)	5		Lung NSC(810;0.0305)|Breast(144;0.222)				TTCAGATACTCTGACTCCACC	0.453		NaN											0	0	0	0.00308	0	6	86									
ITGA2	3673	broad.mit.edu	37	5	52355784	52355784	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:52355784C>T	uc003joy.2	+	11	1397	c.1254C>T	c.(1252-1254)ATC>ATT	p.I418I	ITGA2_uc011cqa.1_RNA|ITGA2_uc011cqb.1_RNA|ITGA2_uc011cqc.1_Silent_p.I342I|ITGA2_uc011cqd.1_RNA|ITGA2_uc011cqe.1_RNA	NM_002203	NP_002194	P17301	ITA2_HUMAN	integrin alpha 2 precursor	418	Extracellular (Potential).|FG-GAP 3.				axon guidance|blood coagulation|cell-matrix adhesion|integrin-mediated signaling pathway|interspecies interaction between organisms|organ morphogenesis	integrin complex	collagen binding|identical protein binding|receptor activity			lung(1)	1		Lung NSC(810;3.11e-05)|Breast(144;0.014)|Prostate(461;0.0181)				GCCATTTGATCTTTCCTAAAC	0.408		NaN											0	0	0	0.009096	0	4	41									
HTR1A	3350	broad.mit.edu	37	5	63257013	63257013	+	Silent	SNP	C	C	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:63257013C>A	uc011cqt.1	-	1	534	c.534G>T	c.(532-534)CCG>CCT	p.P178P		NM_000524	NP_000515	P08908	5HT1A_HUMAN	5-hydroxytryptamine (serotonin) receptor 1A	178	Helical; Name=4; (By similarity).				behavior|positive regulation of cell proliferation	integral to plasma membrane	serotonin receptor activity			ovary(2)|pancreas(2)	4		Lung NSC(810;3.55e-06)|Prostate(74;0.0352)|Ovarian(174;0.0545)|Breast(144;0.0575)|Colorectal(97;0.234)		Lung(70;0.105)	Alprenolol(DB00866)|Aripiprazole(DB01238)|Buspirone(DB00490)|Clozapine(DB00363)|Eletriptan(DB00216)|Ergoloid mesylate(DB01049)|Fluvoxamine(DB00176)|Lisuride(DB00589)|Methysergide(DB00247)|Mirtazapine(DB00370)|Pindolol(DB00960)|Propranolol(DB00571)|Quetiapine(DB01224)|Sertraline(DB01104)|Tegaserod(DB01079)|Trazodone(DB00656)|Venlafaxine(DB00285)|Ziprasidone(DB00246)	AGCGGTCTTCCGGGGTGCGCC	0.597		NaN											1	0	2.51541e-25	0.004878	2.78973e-25	29	143									
VCAN	1462	broad.mit.edu	37	5	82833887	82833887	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:82833887A>G	uc003kii.3	+	8	5421	c.5065A>G	c.(5065-5067)ATT>GTT	p.I1689V	VCAN_uc003kij.3_Missense_Mutation_p.I702V|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Missense_Mutation_p.I353V	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	1689	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		TGCAACCACCATTTATCCAGT	0.398		NaN											0	0	0	0.006122	0	14	72									
VCAN	1462	broad.mit.edu	37	5	82835572	82835572	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:82835572G>A	uc003kii.3	+	8	7106	c.6750G>A	c.(6748-6750)GAG>GAA	p.E2250E	VCAN_uc003kij.3_Silent_p.E1263E|VCAN_uc010jau.2_Intron|VCAN_uc003kik.3_Intron|VCAN_uc003kil.3_Silent_p.E914E	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	2250	GAG-beta.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CAGATACTGAGCTCTTATTCT	0.378		NaN											0	0	0	0.00499	0	15	44									
GPR98	84059	broad.mit.edu	37	5	90149230	90149230	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:90149230G>A	uc003kju.2	+	80	17430	c.17334G>A	c.(17332-17334)CTG>CTA	p.L5778L	GPR98_uc003kjt.2_Silent_p.L3484L|GPR98_uc003kjw.2_Silent_p.L1439L	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	5778	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AGAGGCTACTGGATGTCCAGG	0.398		NaN											0	0	0	0.009096	0	4	24									
WDR36	134430	broad.mit.edu	37	5	110440423	110440423	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:110440423G>A	uc003kpd.2	+	9	1219	c.1102G>A	c.(1102-1104)GAA>AAA	p.E368K	WDR36_uc010jbu.2_RNA	NM_139281	NP_644810	Q8NI36	WDR36_HUMAN	WD repeat domain 36	368	WD 4.				response to stimulus|rRNA processing|visual perception	small-subunit processome				ovary(1)|skin(1)	2		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)		TCCTACAGGTGAAGGCCGACT	0.418		NaN											0	0	0	0.006214	0	9	113									
APC	324	broad.mit.edu	37	5	112178932	112178932	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:112178932G>A	uc010jby.2	+	16	8021	c.7641G>A	c.(7639-7641)TGG>TGA	p.W2547*	APC_uc011cvt.1_Nonsense_Mutation_p.W2529*|APC_uc003kpz.3_Nonsense_Mutation_p.W2547*|APC_uc003kpy.3_Nonsense_Mutation_p.W2547*|APC_uc010jbz.2_Nonsense_Mutation_p.W2264*|APC_uc010jca.2_Nonsense_Mutation_p.W1847*	NM_001127511	NP_001120983	P25054	APC_HUMAN	adenomatous polyposis coli	2547	Ser-rich.				canonical Wnt receptor signaling pathway|cell adhesion|cell cycle arrest|cell migration|cellular component disassembly involved in apoptosis|cytokinesis after mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cyclin-dependent protein kinase activity|negative regulation of microtubule depolymerization|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of pseudopodium assembly|protein complex assembly|regulation of attachment of spindle microtubules to kinetochore|response to DNA damage stimulus|tight junction assembly	adherens junction|APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin destruction complex|centrosome|cytosol|kinetochore|lamellipodium|lateral plasma membrane|nucleus|ruffle membrane|tight junction	beta-catenin binding|gamma-catenin binding|microtubule plus-end binding|protein kinase binding|protein kinase regulator activity	p.?(1)		large_intestine(2123)|stomach(123)|soft_tissue(55)|small_intestine(34)|breast(26)|pancreas(25)|urinary_tract(20)|lung(19)|thyroid(18)|liver(13)|central_nervous_system(10)|ovary(9)|skin(7)|upper_aerodigestive_tract(6)|adrenal_gland(6)|bone(6)|NS(5)|prostate(4)|endometrium(3)|kidney(1)|oesophagus(1)|biliary_tract(1)	2515		all_cancers(142;3.01e-27)|all_epithelial(76;2.3e-18)|all_hematologic(541;4.32e-09)|Ovarian(225;1.78e-06)|Lung NSC(167;0.000195)|Breast(839;0.000231)|all_lung(232;0.000247)|Colorectal(10;0.000355)|Prostate(80;0.00133)		OV - Ovarian serous cystadenocarcinoma(64;1.09e-113)|Epithelial(69;3.79e-112)|all cancers(49;1.67e-104)|BRCA - Breast invasive adenocarcinoma(61;0.00136)|COAD - Colon adenocarcinoma(37;0.00155)|Colorectal(14;0.00191)		CAGGAACCTGGAAACGTGAGC	0.428		12	D|Mis|N|F|S		colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS	colorectal|pancreatic|desmoid|hepatoblastoma|glioma|other CNS			Hereditary_Desmoid_Disease|Familial_Adenomatous_Polyposis|Turcot_syndrome	TSP Lung(16;0.13)			0	0	0	0.001168	0	5	56									
FBN2	2201	broad.mit.edu	37	5	127704904	127704904	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:127704904G>A	uc003kuu.2	-	16	2658	c.2219C>T	c.(2218-2220)CCC>CTC	p.P740L	FBN2_uc003kuv.2_Missense_Mutation_p.P707L	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	740	TB 3.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TGGCTGGCAGGGTTCTCCAAA	0.463		NaN											0	0	0	0.00278	0	20	67									
KIF3A	11127	broad.mit.edu	37	5	132046656	132046656	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:132046656C>T	uc003kxo.2	-	9	1377	c.1223G>A	c.(1222-1224)AGA>AAA	p.R408K	KIF3A_uc003kxn.2_Missense_Mutation_p.R366K|KIF3A_uc011cxf.1_Missense_Mutation_p.R408K|KIF3A_uc003kxp.2_Missense_Mutation_p.R408K	NM_007054	NP_008985	Q9Y496	KIF3A_HUMAN	kinesin family member 3A	408	Potential.				blood coagulation|organelle organization|plus-end-directed vesicle transport along microtubule	centrosome|cytosol|kinesin II complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|protein binding			pancreas(1)	1		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTTACCCCTTCTTTTTTTCCT	0.388		NaN											0	0	0	0.00308	0	4	112									
KIF3A	11127	broad.mit.edu	37	5	132052130	132052130	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:132052130G>A	uc003kxo.2	-	7	915	c.761C>T	c.(760-762)TCA>TTA	p.S254L	KIF3A_uc003kxn.2_Missense_Mutation_p.S213L|KIF3A_uc011cxf.1_Missense_Mutation_p.S254L|KIF3A_uc003kxp.2_Missense_Mutation_p.S254L	NM_007054	NP_008985	Q9Y496	KIF3A_HUMAN	kinesin family member 3A	254	Kinesin-motor.				blood coagulation|organelle organization|plus-end-directed vesicle transport along microtubule	centrosome|cytosol|kinesin II complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|protein binding			pancreas(1)	1		all_cancers(142;0.0751)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			CTGTCTTTCTGAACCCTAGCA	0.328		NaN											0	0	0	0.001984	0	4	58									
PCDHB2	56133	broad.mit.edu	37	5	140475294	140475294	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:140475294A>G	uc003lil.2	+	1	1058	c.920A>G	c.(919-921)CAG>CGG	p.Q307R	PCDHB2_uc003lim.1_5'UTR	NM_018936	NP_061759	Q9Y5E7	PCDB2_HUMAN	protocadherin beta 2 precursor	307	Extracellular (Potential).|Cadherin 3.				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(3)|upper_aerodigestive_tract(2)|pancreas(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			CTTTTAAGACAGAAACTGGAT	0.413		NaN											0	0	0	0.006214	0	7	66									
PCDHGA2	56113	broad.mit.edu	37	5	140719425	140719425	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:140719425C>T	uc003ljk.1	+	1	1072	c.887C>T	c.(886-888)TCA>TTA	p.S296L	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Missense_Mutation_p.S296L	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	296	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GAGCTTAAGTCAACATCTGGA	0.443		NaN											0	0	0	0.006122	0	15	155									
PCDHGA2	56113	broad.mit.edu	37	5	140719466	140719466	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:140719466G>A	uc003ljk.1	+	1	1113	c.928G>A	c.(928-930)GAG>AAG	p.E310K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Missense_Mutation_p.E310K	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	310	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCTAGATTATGAGGATGCTAC	0.413		NaN											0	0	0	0.00499	0	13	176									
PCDHGA2	56113	broad.mit.edu	37	5	140720046	140720046	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:140720046C>G	uc003ljk.1	+	1	1693	c.1508C>G	c.(1507-1509)TCT>TGT	p.S503C	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Missense_Mutation_p.S503C	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	503	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCTTATCCTCTTACATCTCT	0.522		NaN											0	0	0	0.001168	0	6	57									
ARAP3	64411	broad.mit.edu	37	5	141044642	141044642	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:141044642G>A	uc003llm.2	-	19	2725	c.2647C>T	c.(2647-2649)CTG>TTG	p.L883L	ARAP3_uc003lll.2_5'UTR|ARAP3_uc011dbe.1_Silent_p.L545L|ARAP3_uc003lln.2_Silent_p.L785L	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	883					cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7						TCTCCTTGCAGATACAGGGTC	0.667		NaN									OREG0016871	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.001984	0	6	17									
TIGD6	81789	broad.mit.edu	37	5	149375650	149375650	+	Nonsense_Mutation	SNP	C	C	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:149375650C>A	uc003lri.2	-	2	1024	c.262G>T	c.(262-264)GAA>TAA	p.E88*	TIGD6_uc003lrj.2_Nonsense_Mutation_p.E88*	NM_030953	NP_112215	Q17RP2	TIGD6_HUMAN	hypothetical protein LOC81789	88	HTH CENPB-type.				regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			GCATGGATTTCTTGAAACCAA	0.443		NaN											1	0	1.62565e-12	0.012213	1.78643e-12	28	207									
ATP10B	23120	broad.mit.edu	37	5	160047939	160047939	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:160047939T>C	uc003lym.1	-	15	2678	c.1831A>G	c.(1831-1833)AGC>GGC	p.S611G	ATP10B_uc010jit.1_5'UTR|ATP10B_uc003lyn.2_Missense_Mutation_p.S169G	NM_025153	NP_079429	O94823	AT10B_HUMAN	ATPase, class V, type 10B	611	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Renal(175;0.00196)	Medulloblastoma(196;0.0377)|all_neural(177;0.121)	Kidney(164;7.83e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			AGAGCCTTGCTTGAGGGTTTG	0.463		NaN											0	0	0	0.004656	0	21	218									
ADAMTS2	9509	broad.mit.edu	37	5	178555036	178555036	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:178555036G>T	uc003mjw.2	-	17	2541	c.2541C>A	c.(2539-2541)AAC>AAA	p.N847K		NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	847	Spacer.				collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		CTTCCAGGACGTTGTTGTCGT	0.587		NaN											1	0	6.72482e-11	0.003163	7.34953e-11	12	93									
MAPK9	5601	broad.mit.edu	37	5	179675973	179675973	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:179675973C>T	uc003mls.3	-	6	887	c.616G>A	c.(616-618)GTT>ATT	p.V206I	MAPK9_uc003mlt.3_Missense_Mutation_p.V206I|MAPK9_uc010jlc.2_Missense_Mutation_p.V206M|MAPK9_uc003mlv.3_Missense_Mutation_p.V206M|MAPK9_uc011dgx.1_Missense_Mutation_p.V206I	NM_002752	NP_002743	P45984	MK09_HUMAN	mitogen-activated protein kinase 9 isoform JNK2	206	Protein kinase.				innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of gene expression|positive regulation of macrophage derived foam cell differentiation|regulation of sequence-specific DNA binding transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|JUN kinase activity|protein binding|protein binding			central_nervous_system(2)|upper_aerodigestive_tract(1)|large_intestine(1)	4	all_cancers(89;6.54e-05)|all_epithelial(37;1.22e-05)|Renal(175;0.000269)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.137)	all_cancers(40;0.0236)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CTATACTCACCGTTCTCTTTG	0.512		NaN											0	0	0	0.01441	0	34	436									
FLT4	2324	broad.mit.edu	37	5	180048704	180048704	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:180048704G>A	uc003mma.3	-	13	1937	c.1858C>T	c.(1858-1860)CTG>TTG	p.L620L	FLT4_uc003mlz.3_Silent_p.L620L|FLT4_uc003mmb.1_Silent_p.L153L|FLT4_uc011dgy.1_Silent_p.L620L	NM_002020	NP_002011	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4 isoform 2	620	Ig-like C2-type 6.|Extracellular (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			lung(7)|skin(2)|ovary(2)|stomach(1)|central_nervous_system(1)|breast(1)|kidney(1)	15	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	CTGGCGGCCAGAGGGGTGGCG	0.682		NaN							Congenital_Hereditary_Lymphedema				0	0	0	0.009096	0	4	23									
BTNL9	153579	broad.mit.edu	37	5	180475178	180475178	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:180475178C>T	uc003mmt.2	+	3	592	c.361C>T	c.(361-363)CAC>TAC	p.H121Y	BTNL9_uc011dhi.1_Missense_Mutation_p.H52Y	NM_152547	NP_689760	Q6UXG8	BTNL9_HUMAN	butyrophilin-like 9 precursor	121	Extracellular (Potential).|Ig-like V-type.					integral to membrane				ovary(1)|central_nervous_system(1)	2	all_cancers(89;2.45e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			CCTGCAGCTTCACAGCATCAT	0.607		NaN											0	0	0	0.000602	0	5	32									
WRNIP1	56897	broad.mit.edu	37	6	2769089	2769089	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:2769089G>A	uc003mtz.2	+	2	1178	c.987G>A	c.(985-987)GAG>GAA	p.E329E	WRNIP1_uc003mua.2_Silent_p.E329E	NM_020135	NP_064520	Q96S55	WRIP1_HUMAN	Werner helicase interacting protein isoform 1	329					DNA replication|DNA synthesis involved in DNA repair|regulation of DNA-dependent DNA replication initiation	mitochondrion|nucleus|perinuclear region of cytoplasm	ATP binding|ATPase activity|DNA binding|metal ion binding|protein binding			ovary(1)|pancreas(1)	2	Ovarian(93;0.0412)	all_hematologic(90;0.0895)				TTATTGATGAGATTCATCGGT	0.229		NaN											0	0	0	0.001984	0	5	30									
RREB1	6239	broad.mit.edu	37	6	7229455	7229455	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:7229455G>C	uc003mxc.2	+	10	1513	c.1123G>C	c.(1123-1125)GTC>CTC	p.V375L	RREB1_uc003mxb.2_Missense_Mutation_p.V375L|RREB1_uc010jnx.2_Missense_Mutation_p.V375L	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	375					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				CACCAAAGACGTCAGGCCTGC	0.642		NaN											0	0	0	0.009096	0	3	60									
TXNDC5	81567	broad.mit.edu	37	6	7899902	7899902	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:7899902G>A	uc003mxv.2	-	3	458	c.426C>T	c.(424-426)TTC>TTT	p.F142F	TXNDC5_uc003mxw.2_Silent_p.F99F|TXNDC5_uc010jnz.2_Silent_p.F34F|TXNDC5_uc010joa.1_Silent_p.F34F	NM_030810	NP_110437	Q8NBS9	TXND5_HUMAN	thioredoxin domain containing 5 isoform 1	142	Thioredoxin 1.				anti-apoptosis|cell redox homeostasis|cellular membrane organization|glycerol ether metabolic process|post-Golgi vesicle-mediated transport	endoplasmic reticulum lumen|lysosomal lumen	electron carrier activity|isomerase activity|protein disulfide oxidoreductase activity				0	Ovarian(93;0.0398)					GGCCTGGCTTGAAAAGCTTTA	0.438		NaN											0	0	0	0.008291	0	9	59									
HIVEP1	3096	broad.mit.edu	37	6	12123010	12123010	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:12123010G>A	uc003nac.2	+	4	3161	c.2982G>A	c.(2980-2982)ATG>ATA	p.M994I	HIVEP1_uc011diq.1_RNA	NM_002114	NP_002105	P15822	ZEP1_HUMAN	human immunodeficiency virus type I enhancer	994					transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding|zinc ion binding			ovary(3)|large_intestine(1)|central_nervous_system(1)|skin(1)	6	Breast(50;0.0639)|Ovarian(93;0.0816)	all_hematologic(90;0.117)				AGGTAGCCATGAGAGAACCTG	0.473		NaN											0	0	0	0.008291	0	9	256									
DHX16	8449	broad.mit.edu	37	6	30627933	30627933	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:30627933G>A	uc003nqz.2	-	10	1843	c.1631C>T	c.(1630-1632)CCT>CTT	p.P544L	DHX16_uc003nqy.2_Missense_Mutation_p.P63L|DHX16_uc011dmo.1_Missense_Mutation_p.P484L	NM_003587	NP_003578	O60231	DHX16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 16	544	Helicase ATP-binding.				mRNA processing|RNA splicing	nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|RNA helicase activity			ovary(2)|kidney(2)	4						CTTGAGCTCAGGTCGGAAGCG	0.537		NaN											0	0	0	0.001168	0	5	59									
COL11A2	1302	broad.mit.edu	37	6	33146477	33146477	+	Silent	SNP	G	G	A	rs139350991		TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:33146477G>A	uc003ocx.1	-	18	1926	c.1698C>T	c.(1696-1698)CTC>CTT	p.L566L	COL11A2_uc010jul.1_5'Flank|COL11A2_uc003ocy.1_Silent_p.L480L|COL11A2_uc003ocz.1_Silent_p.L459L	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	566	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						TCTCTCCAGGGAGCCCTGGGA	0.562		NaN											0	0	0	0.013537	0	10	194									
YIPF3	25844	broad.mit.edu	37	6	43481144	43481144	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:43481144G>C	uc003ovl.1	-	5	644	c.487C>G	c.(487-489)CTG>GTG	p.L163V	C6orf154_uc003ovk.1_5'Flank|YIPF3_uc011dvk.1_Missense_Mutation_p.L128V|YIPF3_uc010jyr.1_Missense_Mutation_p.L169V|YIPF3_uc010jys.1_Missense_Mutation_p.L6V|YIPF3_uc003ovm.1_Missense_Mutation_p.L37V|YIPF3_uc010jyt.1_Missense_Mutation_p.L112V	NM_015388	NP_056203	Q9GZM5	YIPF3_HUMAN	natural killer cell-specific antigen KLIP1	163	Helical; (Potential).				cell differentiation	integral to membrane|plasma membrane|transport vesicle					0	all_cancers(18;3.79e-05)|Lung NSC(15;0.00217)|all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.00736)|OV - Ovarian serous cystadenocarcinoma(102;0.0711)			ATAGCAACCAGAGTGAAGACC	0.473		NaN											0	0	0	0.00308	0	7	43									
HMGCLL1	54511	broad.mit.edu	37	6	55360227	55360227	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:55360227G>A	uc003pcn.2	-	8	1034	c.875C>T	c.(874-876)ACG>ATG	p.T292M	HMGCLL1_uc003pco.2_Missense_Mutation_p.T262M|HMGCLL1_uc010jzx.2_Missense_Mutation_p.T163M|HMGCLL1_uc011dxc.1_Missense_Mutation_p.T230M|HMGCLL1_uc011dxd.1_Missense_Mutation_p.T159M|HMGCLL1_uc011dxe.1_Intron	NM_019036	NP_061909	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-Coenzyme A	292							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			skin(2)|ovary(1)|pancreas(1)	4	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			CTGAAGGGCCGTAAGGATATT	0.383		NaN											0	0	0	0.008291	0	8	67									
DST	667	broad.mit.edu	37	6	56334713	56334713	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:56334713G>A	uc003pdf.2	-	91	16190	c.16162C>T	c.(16162-16164)CAA>TAA	p.Q5388*	DST_uc003pcz.3_Nonsense_Mutation_p.Q5210*|DST_uc011dxj.1_Nonsense_Mutation_p.Q5239*|DST_uc011dxk.1_Nonsense_Mutation_p.Q5250*|DST_uc003pcy.3_Nonsense_Mutation_p.Q4884*|DST_uc003pcw.3_5'Flank|DST_uc003pcx.3_5'UTR	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	7296	GAR.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TGCTCAACTTGAAATCGCTTT	0.313		NaN											0	0	0	0.00499	0	11	87									
KCNQ5	56479	broad.mit.edu	37	6	73787121	73787121	+	Silent	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:73787121C>G	uc003pgk.2	+	4	1040	c.693C>G	c.(691-693)CTC>CTG	p.L231L	KCNQ5_uc003pgj.3_Silent_p.L231L|KCNQ5_uc011dyh.1_Silent_p.L231L|KCNQ5_uc011dyi.1_Silent_p.L231L|KCNQ5_uc010kat.2_Silent_p.L231L|KCNQ5_uc011dyj.1_Silent_p.L231L|KCNQ5_uc011dyk.1_5'UTR	NM_019842	NP_062816	Q9NR82	KCNQ5_HUMAN	potassium voltage-gated channel, KQT-like	231	Helical; Voltage-sensor; Name=Segment S4; (Potential).				protein complex assembly|synaptic transmission	voltage-gated potassium channel complex	inward rectifier potassium channel activity			ovary(4)|large_intestine(2)|skin(1)	7		all_epithelial(107;0.116)|Lung NSC(302;0.219)		COAD - Colon adenocarcinoma(1;0.0107)|Colorectal(1;0.0583)		CGTCTGCACTCAGAAGTCTCC	0.463		NaN											0	0	0	0.004482	0	7	61									
C6orf167	253714	broad.mit.edu	37	6	97613184	97613184	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:97613184C>T	uc003ppb.2	-	21	3425	c.3159G>A	c.(3157-3159)TTG>TTA	p.L1053L	C6orf167_uc011eaf.1_Silent_p.L1013L	NM_198468	NP_940870	Q6ZRQ5	MMS22_HUMAN	hypothetical protein LOC253714	1053					double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding				0		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.148)|Colorectal(196;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.0457)		CTGTGTTTCTCAATGCCAGCA	0.363		NaN											0	0	0	0.00278	0	18	97									
REV3L	5980	broad.mit.edu	37	6	111702567	111702567	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:111702567G>A	uc003puy.3	-	10	1500	c.1177C>T	c.(1177-1179)CAG>TAG	p.Q393*	REV3L_uc003pux.3_Nonsense_Mutation_p.Q315*|REV3L_uc003puz.3_Nonsense_Mutation_p.Q315*	NM_002912	NP_002903	O60673	DPOLZ_HUMAN	DNA polymerase zeta	393					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			large_intestine(2)|ovary(2)|skin(2)	6		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		GTCAAAGGCTGAAAAGTCTGA	0.343		NaN						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					0	0	0	0.000602	0	5	75									
LAMA4	3910	broad.mit.edu	37	6	112512903	112512903	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:112512903C>G	uc003pvu.2	-	6	962	c.653G>C	c.(652-654)GGA>GCA	p.G218A	LAMA4_uc003pvv.2_Missense_Mutation_p.G218A|LAMA4_uc003pvt.2_Missense_Mutation_p.G218A	NM_001105206	NP_001098676	Q16363	LAMA4_HUMAN	laminin, alpha 4 isoform 1 precursor	218	Laminin EGF-like 3.				cell adhesion|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	extracellular matrix structural constituent|receptor binding			ovary(4)|breast(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	9		all_cancers(87;0.000196)|all_hematologic(75;0.000114)|all_epithelial(87;0.00542)|Colorectal(196;0.0209)		all cancers(137;0.0335)|OV - Ovarian serous cystadenocarcinoma(136;0.0578)|Epithelial(106;0.0748)|BRCA - Breast invasive adenocarcinoma(108;0.242)		ACACTTGAATCCGGTGGTGTT	0.488		NaN											0	0	0	0.009096	0	4	51									
GPRC6A	222545	broad.mit.edu	37	6	117128367	117128367	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:117128367C>T	uc003pxj.1	-	3	523	c.501G>A	c.(499-501)GTG>GTA	p.V167V	GPRC6A_uc003pxk.1_Silent_p.V167V|GPRC6A_uc003pxl.1_Silent_p.V167V	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	167	Extracellular (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		ATTCATAACCCACCTGGAAAT	0.383		NaN											0	0	0	0.001984	0	5	80									
PTPRK	5796	broad.mit.edu	37	6	128326289	128326289	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:128326289G>C	uc003qbk.2	-	15	2798	c.2431C>G	c.(2431-2433)CTG>GTG	p.L811V	PTPRK_uc003qbj.2_Missense_Mutation_p.L812V|PTPRK_uc010kfc.2_Missense_Mutation_p.L812V|PTPRK_uc011ebu.1_Missense_Mutation_p.L812V|PTPRK_uc003qbl.1_Missense_Mutation_p.L706V|PTPRK_uc011ebv.1_Missense_Mutation_p.L822V|PTPRK_uc010kfd.1_Missense_Mutation_p.L25V	NM_002844	NP_002835	Q15262	PTPRK_HUMAN	protein tyrosine phosphatase, receptor type, K	811	Cytoplasmic (Potential).				cell migration|cellular response to reactive oxygen species|cellular response to UV|focal adhesion assembly|negative regulation of cell cycle|negative regulation of cell migration|negative regulation of keratinocyte proliferation|negative regulation of transcription, DNA-dependent|protein localization at cell surface|transforming growth factor beta receptor signaling pathway	adherens junction|cell surface|cell-cell junction|integral to plasma membrane|leading edge membrane	beta-catenin binding|gamma-catenin binding|protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|skin(2)|pancreas(1)|kidney(1)|central_nervous_system(1)	8				all cancers(137;0.0118)|GBM - Glioblastoma multiforme(226;0.0372)|OV - Ovarian serous cystadenocarcinoma(136;0.24)		TCTGCATGCAGAGTGCTCTGA	0.393		NaN											0	0	0	0.00308	0	7	54									
SAMD3	154075	broad.mit.edu	37	6	130505642	130505642	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:130505642C>A	uc003qbv.2	-	7	836	c.510G>T	c.(508-510)ATG>ATT	p.M170I	SAMD3_uc003qbx.2_Missense_Mutation_p.M170I|SAMD3_uc003qbw.2_Missense_Mutation_p.M170I|SAMD3_uc010kfg.1_Missense_Mutation_p.M170I|SAMD3_uc003qby.2_Missense_Mutation_p.M170I|SAMD3_uc003qbz.1_Missense_Mutation_p.M129I	NM_001017373	NP_001017373	Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3 isoform	170										ovary(1)	1				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		TCCTTATCCTCATGCTGTGAT	0.468		NaN											1	0	0.000274275	0.004482	0.000283733	8	54									
SAMD3	154075	broad.mit.edu	37	6	130505656	130505656	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:130505656G>T	uc003qbv.2	-	7	822	c.496C>A	c.(496-498)CCG>ACG	p.P166T	SAMD3_uc003qbx.2_Missense_Mutation_p.P166T|SAMD3_uc003qbw.2_Missense_Mutation_p.P166T|SAMD3_uc010kfg.1_Missense_Mutation_p.P166T|SAMD3_uc003qby.2_Missense_Mutation_p.P166T|SAMD3_uc003qbz.1_Missense_Mutation_p.P125T	NM_001017373	NP_001017373	Q8N6K7	SAMD3_HUMAN	sterile alpha motif domain containing 3 isoform	166										ovary(1)	1				GBM - Glioblastoma multiforme(226;0.00594)|OV - Ovarian serous cystadenocarcinoma(155;0.128)		CTGTGATCCGGGCACTTCTGC	0.453		NaN											1	0	1.23904e-05	0.000602	1.30654e-05	5	57									
ENPP1	5167	broad.mit.edu	37	6	132201159	132201159	+	Silent	SNP	T	T	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:132201159T>C	uc011ecf.1	+	20	2105	c.2085T>C	c.(2083-2085)TAT>TAC	p.Y695Y		NM_006208	NP_006199	P22413	ENPP1_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	695	Nuclease.|Extracellular (Potential).				3'-phosphoadenosine 5'-phosphosulfate metabolic process|biomineral tissue development|cellular phosphate ion homeostasis|cellular response to insulin stimulus|generation of precursor metabolites and energy|immune response|inorganic diphosphate transport|negative regulation of cell growth|negative regulation of fat cell differentiation|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of protein autophosphorylation|nucleoside triphosphate catabolic process|phosphate metabolic process|sequestering of triglyceride|water-soluble vitamin metabolic process	basolateral plasma membrane|cell surface|extracellular space|integral to membrane	ATP binding|insulin receptor binding|metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|protein homodimerization activity|scavenger receptor activity			upper_aerodigestive_tract(2)|ovary(2)	4	Breast(56;0.0505)			GBM - Glioblastoma multiforme(226;0.0216)|OV - Ovarian serous cystadenocarcinoma(155;0.022)	Amifostine(DB01143)|Ribavirin(DB00811)	GGACATCCTATACCGTGGACA	0.403		NaN											0	0	0	0.01441	0	42	192									
PEX7	5191	broad.mit.edu	37	6	137167279	137167279	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:137167279C>G	uc003qhd.2	+	5	588	c.486C>G	c.(484-486)ATC>ATG	p.I162M	PEX7_uc010kgx.2_RNA	NM_000288	NP_000279	O00628	PEX7_HUMAN	peroxisomal biogenesis factor 7	162	WD 3.				ether lipid biosynthetic process|protein import into peroxisome matrix	peroxisome	peroxisome matrix targeting signal-2 binding				0	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000257)|OV - Ovarian serous cystadenocarcinoma(155;0.00492)		ATAGCACAATCTGGTCTCCCC	0.388		NaN											0	0	0	0.001984	0	5	64									
FUCA2	2519	broad.mit.edu	37	6	143828485	143828485	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:143828485C>T	uc003qjm.2	-	2	393	c.301G>A	c.(301-303)GAA>AAA	p.E101K		NM_032020	NP_114409	Q9BTY2	FUCO2_HUMAN	fucosidase, alpha-L- 2, plasma precursor	101					fucose metabolic process	extracellular region	alpha-L-fucosidase activity|cation binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(155;7.45e-06)|GBM - Glioblastoma multiforme(68;0.0142)		CCAAAATCTTCATATTTGAAA	0.373		NaN											0	0	0	0.008291	0	8	128									
SYNE1	23345	broad.mit.edu	37	6	152702384	152702384	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:152702384C>G	uc010kiw.2	-	56	9368	c.8766G>C	c.(8764-8766)GAG>GAC	p.E2922D	SYNE1_uc003qot.3_Missense_Mutation_p.E2929D|SYNE1_uc003qou.3_Missense_Mutation_p.E2922D|SYNE1_uc010kja.1_5'UTR|SYNE1_uc003qov.2_5'UTR|SYNE1_uc010kjb.1_Missense_Mutation_p.E2905D	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	2922	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GGGCCTGCATCTCCGTGTGCA	0.577		NaN								HNSCC(10;0.0054)			0	0	0	0.00245	0	11	146									
SLC22A1	6580	broad.mit.edu	37	6	160555032	160555032	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:160555032C>T	uc003qtc.2	+	4	819	c.714C>T	c.(712-714)ATC>ATT	p.I238I	SLC22A1_uc003qtd.2_Silent_p.I238I	NM_003057	NP_003048	O15245	S22A1_HUMAN	solute carrier family 22 member 1 isoform a	238	Helical; (Potential).					basolateral plasma membrane|integral to plasma membrane|membrane fraction	organic cation transmembrane transporter activity|protein binding				0		Breast(66;0.000776)|Ovarian(120;0.00556)		OV - Ovarian serous cystadenocarcinoma(65;2.73e-17)|BRCA - Breast invasive adenocarcinoma(81;1.1e-06)		CGGTGGCGATCATGTACCAGA	0.632		NaN											0	0	0	0.001984	0	5	66									
LPA	4018	broad.mit.edu	37	6	160978430	160978430	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:160978430G>C	uc003qtl.2	-	30	4925	c.4805C>G	c.(4804-4806)TCT>TGT	p.S1602C		NM_005577	NP_005568	P08519	APOA_HUMAN	lipoprotein Lp(a) precursor	4110	Kringle 36.				blood circulation|lipid metabolic process|lipid transport|lipoprotein metabolic process|proteolysis|receptor-mediated endocytosis	plasma lipoprotein particle	apolipoprotein binding|endopeptidase inhibitor activity|fibronectin binding|heparin binding|serine-type endopeptidase activity			ovary(3)|skin(2)|pancreas(1)	6		Breast(66;0.000496)|Ovarian(120;0.0303)|Prostate(117;0.0965)		OV - Ovarian serous cystadenocarcinoma(65;2.5e-17)|BRCA - Breast invasive adenocarcinoma(81;6.48e-06)	Aminocaproic Acid(DB00513)	ACCTGCTTCAGAATGAGCCTC	0.458		NaN											0	0	0	0.006214	0	7	111									
THBS2	7058	broad.mit.edu	37	6	169623568	169623568	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:169623568C>A	uc003qwt.2	-	19	3024	c.2776G>T	c.(2776-2778)GAT>TAT	p.D926Y		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	926	TSP type-3 8.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		CCCCGTCCATCACCTATGCAC	0.373		NaN											1	0	3.59834e-05	0.001168	3.77448e-05	6	85									
AHR	196	broad.mit.edu	37	7	17382607	17382607	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:17382607G>C	uc011jxz.1	+	11	3079	c.2466G>C	c.(2464-2466)CAG>CAC	p.Q822H	AHR_uc003stt.3_RNA	NM_001621	NP_001612	P35869	AHR_HUMAN	aryl hydrocarbon receptor precursor	822				LNETYPAELNNINNTQTTTHLQPLHHPSEARPFPDLTSSGF L -> FK (in Ref. 1; BAA03857).	apoptosis|blood vessel development|cell cycle|regulation of B cell proliferation|response to stress|transcription from RNA polymerase II promoter|xenobiotic metabolic process	cytosolic aryl hydrocarbon receptor complex|transcription factor complex	Hsp90 protein binding|ligand-dependent nuclear receptor activity|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			urinary_tract(1)|kidney(1)|pancreas(1)	3	Lung NSC(10;0.0392)|all_lung(11;0.0754)					ATAACACTCAGACTACCACAC	0.368		NaN											0	0	0	0.01441	0	45	149									
NPSR1	387129	broad.mit.edu	37	7	34917785	34917785	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:34917785C>T	uc003tei.1	+	9	1251	c.1123C>T	c.(1123-1125)CTT>TTT	p.L375F	NPSR1_uc010kww.1_Missense_Mutation_p.L364F|NPSR1_uc011kar.1_Missense_Mutation_p.L309F	NM_207173	NP_997056	Q6W5P4	NPSR1_HUMAN	G protein-coupled receptor for asthma	Error:Variant_position_missing_in_Q6W5P4_after_alignment						cytoplasm|integral to membrane|plasma membrane	vasopressin receptor activity			skin(3)|pancreas(1)	4					Halothane(DB01159)	TTCCTGGGCTCTTCCAAGGTG	0.557		NaN											0	0	0	0.009096	0	4	17									
TARP	445347	broad.mit.edu	37	7	38304969	38304969	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:38304969G>C	uc003tge.1	-	5	1115	c.738C>G	c.(736-738)ATC>ATG	p.I246M	uc003tfz.1_Intron|TARP_uc003tgb.2_Missense_Mutation_p.I42M|TARP_uc003tgc.1_Missense_Mutation_p.I42M|TARP_uc003tgd.1_Missense_Mutation_p.I42M|TARP_uc010kxi.1_RNA|TARP_uc003tgf.1_RNA|TARP_uc003tgj.1_RNA|TARP_uc003tgh.1_RNA|TARP_uc003tgi.1_RNA|TARP_uc003tgg.1_RNA			A2JGV3	A2JGV3_HUMAN	Homo sapiens TCRgamma alternate reading frame protein (TCRg) mRNA, complete cds.	Error:Variant_position_missing_in_A2JGV3_after_alignment											0						TTGGAGGAAAGATAATTTCTT	0.348		NaN											0	0	0	0.009096	0	4	33									
PKD1L1	168507	broad.mit.edu	37	7	47898448	47898448	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:47898448G>A	uc003tny.1	-	27	4185	c.4185C>T	c.(4183-4185)TAC>TAT	p.Y1395Y		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1395	Extracellular (Potential).|REJ.				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						GTGCCCGGGTGTACTTGAGGA	0.502		NaN											0	0	0	0.009096	0	3	49									
ZNF727	442319	broad.mit.edu	37	7	63538396	63538396	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:63538396G>A	uc011kdm.1	+	4	1148	c.969G>A	c.(967-969)TGG>TGA	p.W323*		NM_001159522	NP_001152994	A8MUV8	ZN727_HUMAN	zinc finger protein 727	323	C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTTTTATGTGGATCTCGGCCC	0.388		NaN											0	0	0	0.004672	0	3	31									
TPST1	8460	broad.mit.edu	37	7	65705934	65705934	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:65705934C>T	uc003tuw.2	+	2	874	c.522C>T	c.(520-522)TTC>TTT	p.F174F	TPST1_uc010kzy.2_Intron|TPST1_uc010kzz.2_Silent_p.F174F|TPST1_uc010laa.2_Silent_p.F174F	NM_003596	NP_003587	O60507	TPST1_HUMAN	tyrosylprotein sulfotransferase 1	174	Lumenal (Potential).				inflammatory response|peptidyl-tyrosine sulfation	Golgi membrane|integral to membrane|membrane fraction	protein-tyrosine sulfotransferase activity				0						CTAGGTTATTCCCCAATGCCA	0.398		NaN											0	0	0	0.000602	0	5	68									
BAZ1B	9031	broad.mit.edu	37	7	72891929	72891929	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:72891929G>C	uc003tyc.2	-	7	2207	c.1862C>G	c.(1861-1863)TCT>TGT	p.S621C		NM_032408	NP_115784	Q9UIG0	BAZ1B_HUMAN	bromodomain adjacent to zinc finger domain, 1B	621	DDT.				ATP-dependent chromatin remodeling|chromatin-mediated maintenance of transcription|DNA replication-dependent nucleosome disassembly|double-strand break repair|heart morphogenesis|transcription, DNA-dependent	WINAC complex	ATP binding|chromatin binding|histone acetyl-lysine binding|histone kinase activity|non-membrane spanning protein tyrosine kinase activity|protein complex scaffold|vitamin D receptor activator activity|vitamin D receptor binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	7		Lung NSC(55;0.0659)|all_lung(88;0.152)				AAGTAGCCCAGAATAACAGCT	0.478		NaN											0	0	0	0.000602	0	5	59									
PCLO	27445	broad.mit.edu	37	7	82579161	82579161	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:82579161C>T	uc003uhx.2	-	6	11032	c.10743G>A	c.(10741-10743)CTG>CTA	p.L3581L	PCLO_uc003uhv.2_Silent_p.L3581L|PCLO_uc010lec.2_Silent_p.L546L	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3512					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						ATGTGGCACTCAGATATTGAG	0.438		NaN											0	0	0	0.001984	0	7	52									
GRM3	2913	broad.mit.edu	37	7	86469220	86469220	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:86469220G>A	uc003uid.2	+	4	3489	c.2390G>A	c.(2389-2391)AGA>AAA	p.R797K	GRM3_uc010lef.2_Intron|GRM3_uc010leg.2_Missense_Mutation_p.R669K|GRM3_uc010leh.2_Missense_Mutation_p.R389K	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	797	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	AGTGACTACAGAGTAAGTCTT	0.353		NaN											0	0	0	0.001168	0	5	74									
ADAM22	53616	broad.mit.edu	37	7	87757941	87757941	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:87757941G>C	uc003ujn.2	+	9	782	c.703G>C	c.(703-705)GAA>CAA	p.E235Q	ADAM22_uc003uji.1_Missense_Mutation_p.E234Q|ADAM22_uc003ujj.1_Missense_Mutation_p.E235Q|ADAM22_uc003ujk.1_Missense_Mutation_p.E235Q|ADAM22_uc003ujl.1_Missense_Mutation_p.E235Q|ADAM22_uc003ujm.2_Missense_Mutation_p.E235Q|ADAM22_uc003ujo.2_Missense_Mutation_p.E235Q|ADAM22_uc003ujp.1_Missense_Mutation_p.E287Q	NM_021723	NP_068369	Q9P0K1	ADA22_HUMAN	ADAM metallopeptidase domain 22 isoform 1	235	Extracellular (Potential).				cell adhesion|central nervous system development|negative regulation of cell adhesion|proteolysis	integral to membrane	integrin binding|metalloendopeptidase activity|protein binding|receptor activity|zinc ion binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Esophageal squamous(14;0.00202)		STAD - Stomach adenocarcinoma(171;0.215)			TCGTAATGTAGAAGAAGAAAC	0.393		NaN											0	0	0	0.008291	0	9	133									
MCM7	4176	broad.mit.edu	37	7	99695470	99695470	+	Silent	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:99695470C>G	uc003usw.1	-	8	1482	c.972G>C	c.(970-972)CTG>CTC	p.L324L	MCM7_uc003usv.1_Silent_p.L148L|MCM7_uc003usx.1_Silent_p.L148L	NM_005916	NP_005907	P33993	MCM7_HUMAN	minichromosome maintenance complex component 7	324					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|regulation of phosphorylation|response to DNA damage stimulus|S phase of mitotic cell cycle	chromatin|MCM complex	ATP binding|protein binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)				Atorvastatin(DB01076)	CAATTTGCCTCAGCTCCTCCC	0.493		NaN											0	0	0	0.010729	0	10	122									
ZCWPW1	55063	broad.mit.edu	37	7	99998716	99998716	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:99998716C>G	uc003uut.2	-	18	2116	c.1868G>C	c.(1867-1869)AGA>ACA	p.R623T	ZCWPW1_uc011kjq.1_Missense_Mutation_p.R503T|ZCWPW1_uc003uur.2_3'UTR|ZCWPW1_uc003uus.2_Missense_Mutation_p.R452T|ZCWPW1_uc011kjr.1_3'UTR|ZCWPW1_uc011kjp.1_RNA	NM_017984	NP_060454	Q9H0M4	ZCPW1_HUMAN	zinc finger, CW type with PWWP domain 1	623							zinc ion binding				0	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CCCCAGCTCTCTCCCAACATC	0.622		NaN											0	0	0	0.00308	0	5	53									
GIGYF1	64599	broad.mit.edu	37	7	100283075	100283075	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:100283075G>A	uc003uwg.1	-	10	2093	c.1084C>T	c.(1084-1086)CAG>TAG	p.Q362*		NM_022574	NP_072096	O75420	PERQ1_HUMAN	PERQ amino acid rich, with GYF domain 1	362										large_intestine(1)|central_nervous_system(1)	2	Lung NSC(181;0.035)|all_lung(186;0.0509)|Esophageal squamous(72;0.0817)					TTCTCCTCCTGAGGAGGCAGT	0.627		NaN											0	0	0	0.009096	0	4	30									
MUC17	140453	broad.mit.edu	37	7	100696366	100696366	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:100696366G>A	uc003uxp.1	+	10	13256	c.13203G>A	c.(13201-13203)CTG>CTA	p.L4401L	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	4401	Helical; (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					GGGTCGTGCTGATGCTGATCA	0.597		NaN											0	0	0	0.001984	0	6	47									
ORC5L	5001	broad.mit.edu	37	7	103848302	103848302	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:103848302G>A	uc003vcb.2	-	1	162	c.51C>T	c.(49-51)ATC>ATT	p.I17I	ORC5L_uc011klp.1_5'UTR|ORC5L_uc003vcc.2_Silent_p.I17I|ORC5L_uc003vcd.2_Silent_p.I17I	NM_002553	NP_002544	O43913	ORC5_HUMAN	origin recognition complex subunit 5 isoform 1	17					cell cycle checkpoint|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	cytoplasm|nuclear origin of replication recognition complex|nucleoplasm	ATP binding|DNA replication origin binding|identical protein binding				0						AGGACTGCAAGATGGACACTT	0.517		NaN											0	0	0	0.013537	0	11	100									
LAMB1	3912	broad.mit.edu	37	7	107626630	107626630	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:107626630G>T	uc003vew.2	-	6	937	c.602C>A	c.(601-603)ACT>AAT	p.T201N	LAMB1_uc003vev.2_Missense_Mutation_p.T225N|LAMB1_uc003vex.2_Missense_Mutation_p.T201N|LAMB1_uc010ljn.1_Missense_Mutation_p.T287N	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	201	Laminin N-terminal.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	CTCTCCTTCAGTTGAGGGTTC	0.378		NaN											1	0	2.23348e-06	0.004007	2.3845e-06	13	74									
IMMP2L	83943	broad.mit.edu	37	7	110526696	110526696	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:110526696C>T	uc003vfq.1	-	5	804	c.361G>A	c.(361-363)GAA>AAA	p.E121K	IMMP2L_uc010ljr.1_Missense_Mutation_p.E121K	NM_032549	NP_115938	Q96T52	IMP2L_HUMAN	IMP2 inner mitochondrial membrane protease-like	121					protein processing involved in protein targeting to mitochondrion|proteolysis	integral to membrane|mitochondrial inner membrane peptidase complex|nucleus	serine-type peptidase activity				0				UCEC - Uterine corpus endometrioid carcinoma (4;0.053)|Epithelial(3;2.27e-07)|all cancers(3;1.36e-05)|STAD - Stomach adenocarcinoma(3;0.00148)|KIRC - Kidney renal clear cell carcinoma(11;0.0339)|Lung(3;0.0375)|Kidney(11;0.0415)|LUSC - Lung squamous cell carcinoma(290;0.173)		TGATCACCTTCAACCCAGATG	0.403		NaN											0	0	0	0.00308	0	6	73									
EXOC4	60412	broad.mit.edu	37	7	132973814	132973814	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:132973814C>G	uc003vrk.2	+	3	450	c.415C>G	c.(415-417)CAA>GAA	p.Q139E	EXOC4_uc011kpo.1_Missense_Mutation_p.Q38E|EXOC4_uc003vri.2_Missense_Mutation_p.Q139E|EXOC4_uc003vrj.2_Missense_Mutation_p.Q139E	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	139					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				GCAAGTGCCTCAAAAGCTGGA	0.443		NaN											0	0	0	0.006214	0	8	40									
AKR1D1	6718	broad.mit.edu	37	7	137782615	137782615	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:137782615G>A	uc003vtz.2	+	4	451	c.382G>A	c.(382-384)GGA>AGA	p.G128R	AKR1D1_uc011kqb.1_Missense_Mutation_p.G128R|AKR1D1_uc011kqc.1_RNA|AKR1D1_uc011kqd.1_Intron|AKR1D1_uc011kqe.1_Missense_Mutation_p.G128R|AKR1D1_uc011kqf.1_Missense_Mutation_p.G128R|AKR1D1_uc010lmy.1_RNA	NM_005989	NP_005980	P51857	AK1D1_HUMAN	aldo-keto reductase family 1, member D1	128					androgen metabolic process|bile acid biosynthetic process|bile acid catabolic process|C21-steroid hormone metabolic process|cholesterol catabolic process|digestion	cytosol	aldo-keto reductase (NADP) activity|delta4-3-oxosteroid 5beta-reductase activity|steroid binding			skin(1)	1						ttttCAGCCAGGAGATGAAAT	0.234		NaN											0	0	0	0.007291	0	25	74									
JHDM1D	80853	broad.mit.edu	37	7	139826545	139826545	+	Silent	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:139826545G>C	uc003vvm.2	-	6	784	c.780C>G	c.(778-780)GTC>GTG	p.V260V		NM_030647	NP_085150	Q6ZMT4	KDM7_HUMAN	jumonji C domain containing histone demethylase	260	JmjC.				midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1	Melanoma(164;0.0142)					GCTTGGGAAAGACTGAATCAT	0.403		NaN											0	0	0	0.013537	0	13	84									
MGAM	8972	broad.mit.edu	37	7	141752666	141752666	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:141752666G>A	uc003vwy.2	+	26	3095	c.3041G>A	c.(3040-3042)GGG>GAG	p.G1014E		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1014	Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	AATTCCCATGGGGCCACAGCT	0.463		NaN											0	0	0	0.00278	0	21	103									
MGAM	8972	broad.mit.edu	37	7	141759285	141759285	+	Nonsense_Mutation	SNP	C	C	G	rs146623163	by1000genomes	TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:141759285C>G	uc003vwy.2	+	32	3887	c.3833C>G	c.(3832-3834)TCA>TGA	p.S1278*		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1278	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	GTGCAGTACTCAGACATCGAC	0.567		NaN											0	0	0	0.00308	0	8	24									
ARHGEF35	445328	broad.mit.edu	37	7	143884376	143884376	+	Missense_Mutation	SNP	T	T	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:143884376T>G	uc003wdz.1	-	2	1219	c.1101A>C	c.(1099-1101)AAA>AAC	p.K367N		NM_001003702	NP_001003702	A5YM69	ARG35_HUMAN	Rho guanine nucleotide exchange factor (GEF)	367	Glu-rich.										0						CTGGGACCCCTTTCTCCTTTA	0.537		NaN											0	0	0	0.009096	0	4	32									
MLL3	58508	broad.mit.edu	37	7	151927028	151927028	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr7:151927028G>C	uc003wla.2	-	18	3175	c.2956C>G	c.(2956-2958)CCA>GCA	p.P986A	MLL3_uc003wkz.2_Missense_Mutation_p.P47A	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	986	PHD-type 4.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		ACACAGTATGGATGGTAACAC	0.368		NaN	N		medulloblastoma								0	0	0	0.004656	0	10	403									
ARHGEF10	9639	broad.mit.edu	37	8	1806263	1806263	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:1806263G>A	uc003wpr.2	+	3	353	c.175G>A	c.(175-177)GAA>AAA	p.E59K	ARHGEF10_uc003wpq.1_Missense_Mutation_p.E83K|ARHGEF10_uc003wps.2_Missense_Mutation_p.E59K|ARHGEF10_uc003wpt.2_5'Flank|ARHGEF10_uc010lrd.1_5'Flank|ARHGEF10_uc003wpu.2_5'Flank	NM_014629	NP_055444	O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor 10	83					centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		TGGAGCCAGTGAAGCCCCTGC	0.338		NaN											0	0	0	0.009096	0	4	24									
ASAH1	427	broad.mit.edu	37	8	17928835	17928835	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:17928835C>T	uc003wyl.2	-	3	502	c.190G>A	c.(190-192)GAA>AAA	p.E64K	ASAH1_uc010ltb.1_RNA|ASAH1_uc003wym.2_Missense_Mutation_p.E64K|ASAH1_uc003wyn.2_Missense_Mutation_p.E80K|ASAH1_uc003wyo.2_Missense_Mutation_p.E87K	NM_177924	NP_808592	Q13510	ASAH1_HUMAN	N-acylsphingosine amidohydrolase 1 isoform a	64					ceramide metabolic process	lysosome	ceramidase activity				0				Colorectal(111;0.0646)|COAD - Colon adenocarcinoma(73;0.228)		AGCATCAATTCATGCCATCTT	0.299		NaN											0	0	0	0.001984	0	4	22									
RB1CC1	9821	broad.mit.edu	37	8	53586766	53586766	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:53586766C>G	uc003xre.3	-	7	1199	c.641G>C	c.(640-642)AGA>ACA	p.R214T	RB1CC1_uc003xrf.3_Missense_Mutation_p.R214T	NM_014781	NP_055596	Q8TDY2	RBCC1_HUMAN	Rb1-inducible coiled coil protein 1 isoform 1	214					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			ovary(8)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	11		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				CAAACATTCTCTGTAACTATG	0.398		NaN											0	0	0	0.006214	0	9	135									
RP1	6101	broad.mit.edu	37	8	55533796	55533796	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:55533796C>T	uc003xsd.1	+	2	418	c.270C>T	c.(268-270)CAC>CAT	p.H90H	RP1_uc011ldy.1_Silent_p.H90H	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	90	Doublecortin 1.				axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			GGGGCAGGCACAGCATCACGC	0.607		NaN											0	0	0	0.006214	0	8	132									
UBXN2B	137886	broad.mit.edu	37	8	59345738	59345738	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:59345738A>T	uc003xtl.2	+	4	481	c.359A>T	c.(358-360)TAC>TTC	p.Y120F		NM_001077619	NP_001071087	Q14CS0	UBX2B_HUMAN	UBX domain protein 2B	120						cytosol|endoplasmic reticulum|Golgi apparatus|nucleus				ovary(2)	2						GGTGGAGGATACAGATTGGGT	0.289		NaN											0	0	0	0.010504	0	15	242									
VCPIP1	80124	broad.mit.edu	37	8	67576615	67576615	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:67576615G>A	uc003xwn.2	-	1	2838	c.2579C>T	c.(2578-2580)TCT>TTT	p.S860F		NM_025054	NP_079330	Q96JH7	VCIP1_HUMAN	valosin containing protein (p97)/p47 complex	860					protein ubiquitination	endoplasmic reticulum|Golgi stack	ubiquitin-specific protease activity			lung(2)|ovary(2)|central_nervous_system(1)|breast(1)|skin(1)|kidney(1)	8		Lung NSC(129;0.142)|all_lung(136;0.227)	Epithelial(68;0.000771)|OV - Ovarian serous cystadenocarcinoma(28;0.00248)|all cancers(69;0.00296)|BRCA - Breast invasive adenocarcinoma(89;0.149)			TGCTGCAGCAGACTGACCACC	0.428		NaN											0	0	0	0.001984	0	5	96									
FAM82B	51115	broad.mit.edu	37	8	87486538	87486538	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:87486538C>T	uc003ydu.2	-	10	1104	c.944G>A	c.(943-945)TGA>TAA	p.*315*	FAM82B_uc011lfz.1_Silent_p.*272*|FAM82B_uc011lga.1_Silent_p.*285*	NM_016033	NP_057117	Q96DB5	RMD1_HUMAN	regulator of microtubule dynamics 1	315						microtubule|spindle pole	binding			ovary(1)	1						GAAAAGTTCTCAATTCTTCTC	0.299		NaN											0	0	0	0.006214	0	6	95									
FAM82B	51115	broad.mit.edu	37	8	87486543	87486543	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:87486543C>T	uc003ydu.2	-	10	1099	c.939G>A	c.(937-939)AAG>AAA	p.K313K	FAM82B_uc011lfz.1_Silent_p.K270K|FAM82B_uc011lga.1_Silent_p.K283K	NM_016033	NP_057117	Q96DB5	RMD1_HUMAN	regulator of microtubule dynamics 1	313						microtubule|spindle pole	binding			ovary(1)	1						GTTCTCAATTCTTCTCACTGA	0.308		NaN											0	0	0	0.010729	0	9	100									
DCAF4L2	138009	broad.mit.edu	37	8	88885230	88885230	+	Nonsense_Mutation	SNP	C	C	A	rs138662456	by1000genomes	TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:88885230C>A	uc003ydz.2	-	1	1067	c.970G>T	c.(970-972)GAA>TAA	p.E324*		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	324	WD 2.									ovary(1)	1						CCTTCTTCTTCGTTCACATGC	0.552		NaN											1	0	0.00448238	0.004482	0.00458947	8	57									
VPS13B	157680	broad.mit.edu	37	8	100712095	100712095	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:100712095G>A	uc003yiv.2	+	36	6575	c.6464G>A	c.(6463-6465)TGC>TAC	p.C2155Y	VPS13B_uc003yiw.2_Missense_Mutation_p.C2130Y	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	2155					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			AGCAAACCATGCCTGTTAGCA	0.443		NaN											0	0	0	0.004482	0	8	56									
ODF1	4956	broad.mit.edu	37	8	103564039	103564039	+	Silent	SNP	C	C	T	rs142790437		TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:103564039C>T	uc003ykt.2	+	1	192	c.84C>T	c.(82-84)ATC>ATT	p.I28I		NM_024410	NP_077721	Q14990	ODFP1_HUMAN	outer dense fiber of sperm tails 1	28					cell differentiation|multicellular organismal development|spermatogenesis	outer dense fiber	structural molecule activity			ovary(2)	2	all_cancers(14;2.76e-05)|all_epithelial(15;4.54e-08)|Lung NSC(17;4.08e-05)|all_lung(17;9.15e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000125)|STAD - Stomach adenocarcinoma(118;0.0826)			TGAGATGCATCGACGAATTTA	0.483		NaN											0	0	0	0.003954	0	25	145									
FZD6	8323	broad.mit.edu	37	8	104337008	104337008	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:104337008G>C	uc003ylh.2	+	4	958	c.674G>C	c.(673-675)AGA>ACA	p.R225T	FZD6_uc003yli.2_Missense_Mutation_p.R225T|FZD6_uc003ylj.2_Missense_Mutation_p.R225T|FZD6_uc011lhn.1_Missense_Mutation_p.R191T|FZD6_uc011lho.1_Intron|FZD6_uc011lhp.1_Missense_Mutation_p.R170T	NM_003506	NP_003497	O60353	FZD6_HUMAN	frizzled 6 isoform a precursor	225	Cytoplasmic (Potential).				angiogenesis|axonogenesis|cell proliferation in midbrain|establishment of planar polarity|G-protein signaling, coupled to cGMP nucleotide second messenger|gonad development|inner ear morphogenesis|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of sequence-specific DNA binding transcription factor activity|neural tube closure|non-canonical Wnt receptor signaling pathway	apical part of cell|apicolateral plasma membrane|cytoplasm|integral to plasma membrane|neuron projection membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(57;2.86e-05)|STAD - Stomach adenocarcinoma(118;0.197)			ATTGATGTTAGAAGATTCAGA	0.333		NaN											0	0	0	0.001168	0	6	47									
LRP12	29967	broad.mit.edu	37	8	105509412	105509412	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:105509412G>A	uc003yma.2	-	5	1463	c.1368C>T	c.(1366-1368)TTC>TTT	p.F456F	LRP12_uc003ymb.2_Silent_p.F437F|LRP12_uc003ylz.2_5'Flank	NM_013437	NP_038465	Q9Y561	LRP12_HUMAN	low density lipoprotein-related protein 12	456	Extracellular (Potential).|LDL-receptor class A 5.				endocytosis|regulation of growth	coated pit|integral to plasma membrane	low-density lipoprotein receptor activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(57;1.21e-06)|STAD - Stomach adenocarcinoma(118;0.229)			TTTTACAATGGAAATTTCCTG	0.418		NaN											0	0	0	0.008871	0	15	102									
NUDCD1	84955	broad.mit.edu	37	8	110255327	110255327	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:110255327G>A	uc003ynb.3	-	10	1774	c.1663C>T	c.(1663-1665)CCT>TCT	p.P555S	NUDCD1_uc003yna.2_Missense_Mutation_p.P526S|NUDCD1_uc010mcl.2_Missense_Mutation_p.P468S	NM_032869	NP_116258	Q96RS6	NUDC1_HUMAN	NudC domain containing 1 isoform 1	555										ovary(1)|breast(1)	2	all_neural(195;0.219)		OV - Ovarian serous cystadenocarcinoma(57;1.56e-12)			CCTAAAATAGGATCATTGGTT	0.368		NaN											0	0	0	0.004289	0	32	212									
CSMD3	114788	broad.mit.edu	37	8	113267562	113267562	+	Silent	SNP	A	A	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:113267562A>G	uc003ynu.2	-	62	10116	c.9957T>C	c.(9955-9957)TTT>TTC	p.F3319F	CSMD3_uc003yns.2_Silent_p.F2521F|CSMD3_uc003ynt.2_Silent_p.F3279F|CSMD3_uc011lhx.1_Silent_p.F3150F	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3319	Extracellular (Potential).|Sushi 26.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						ATATGAAAGGAAAATTGCAGC	0.413		NaN								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			0	0	0	0.006214	0	9	55									
NOV	4856	broad.mit.edu	37	8	120430374	120430374	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:120430374C>A	uc003yoq.2	+	3	608	c.387C>A	c.(385-387)TTC>TTA	p.F129L		NM_002514	NP_002505	P48745	NOV_HUMAN	nephroblastoma overexpressed precursor	129	VWFC.				regulation of cell growth		growth factor activity|insulin-like growth factor binding			ovary(2)|skin(2)|kidney(1)	5	all_cancers(13;3.84e-26)|Lung NSC(37;1.19e-08)|Ovarian(258;0.0249)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.000507)		Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	GCTGCAAATTCCAGTGCACCT	0.527		NaN											1	0	1.12685e-05	0.004482	1.19034e-05	9	56									
TG	7038	broad.mit.edu	37	8	133880419	133880419	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:133880419C>T	uc003ytw.2	+	2	168	c.127C>T	c.(127-129)CTG>TTG	p.L43L		NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor	43	Thyroglobulin type-1 1.				hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		AACGGCCTTTCTGAAGCAAGC	0.517		NaN											0	0	0	0.013537	0	9	83									
TG	7038	broad.mit.edu	37	8	133945805	133945805	+	Splice_Site	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:133945805G>A	uc003ytw.2	+	24	4858	c.4817_splice	c.e24-1	p.D1606_splice	TG_uc010mdw.2_Splice_Site_p.D365_splice|TG_uc011ljb.1_Splice_Site_p.D39_splice	NM_003235	NP_003226	P01266	THYG_HUMAN	thyroglobulin precursor						hormone biosynthetic process|signal transduction|thyroid gland development|thyroid hormone generation	extracellular space	hormone activity			ovary(8)|breast(4)|pancreas(1)|central_nervous_system(1)|skin(1)	15	Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0559)|Breast(495;0.0735)	BRCA - Breast invasive adenocarcinoma(115;0.000701)	KIRC - Kidney renal clear cell carcinoma(542;0.0546)		GGTGCTTGCAGATTGCACAGA	0.567		NaN											0	0	0	0.00245	0	10	105									
FAM135B	51059	broad.mit.edu	37	8	139158273	139158273	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:139158273G>T	uc003yuy.2	-	15	3640	c.3469C>A	c.(3469-3471)CTG>ATG	p.L1157M	FAM135B_uc003yux.2_Missense_Mutation_p.L1058M|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.L719M|FAM135B_uc003yvb.2_Missense_Mutation_p.A684D	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1157										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			GTCTTTACCAGCCGGAGGTCT	0.433		NaN								HNSCC(54;0.14)			1	0	0.00010058	0.013537	0.000104953	12	51									
FAM135B	51059	broad.mit.edu	37	8	139160802	139160802	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:139160802C>T	uc003yuy.2	-	14	3580	c.3409G>A	c.(3409-3411)GAT>AAT	p.D1137N	FAM135B_uc003yux.2_Missense_Mutation_p.D1038N|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.D699N|FAM135B_uc003yvb.2_Missense_Mutation_p.R664K	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1137										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TGAATTCCATCTTCCAAATTT	0.358		NaN								HNSCC(54;0.14)			0	0	0	0.00245	0	11	86									
FAM135B	51059	broad.mit.edu	37	8	139278012	139278012	+	Silent	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:139278012C>G	uc003yuy.2	-	4	402	c.231G>C	c.(229-231)CGG>CGC	p.R77R	FAM135B_uc003yux.2_5'UTR|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	77										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CCTCTTCATTCCGGTATAAGA	0.493		NaN								HNSCC(54;0.14)			0	0	0	0.001984	0	6	74									
NAPRT1	93100	broad.mit.edu	37	8	144660103	144660103	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:144660103G>C	uc003yym.3	-	2	262	c.237C>G	c.(235-237)TTC>TTG	p.F79L	NAPRT1_uc003yyn.3_Missense_Mutation_p.F79L|NAPRT1_uc011lkh.1_Missense_Mutation_p.F79L|NAPRT1_uc003yyo.3_Missense_Mutation_p.F79L	NM_145201	NP_660202	Q6XQN6	PNCB_HUMAN	nicotinate phosphoribosyltransferase domain	79					nicotinamide metabolic process|nicotinate nucleotide salvage|response to oxidative stress|water-soluble vitamin metabolic process	cytosol|Golgi apparatus|nucleus	nicotinate phosphoribosyltransferase activity|nicotinate-nucleotide diphosphorylase (carboxylating) activity			ovary(1)	1	all_cancers(97;6.49e-11)|all_epithelial(106;4.73e-09)|Lung NSC(106;0.000202)|all_lung(105;0.000548)|Ovarian(258;0.014)|Acute lymphoblastic leukemia(118;0.155)		Colorectal(110;0.134)|BRCA - Breast invasive adenocarcinoma(115;0.146)			CCGAGGCCAGGAACTGCACGT	0.672		NaN											0	0	0	0.000602	0	3	62									
PUF60	22827	broad.mit.edu	37	8	144899273	144899273	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:144899273G>A	uc003yzs.2	-	11	1251	c.1187C>T	c.(1186-1188)TCG>TTG	p.S396L	SCRIB_uc003yzo.1_5'Flank|SCRIB_uc003yzp.1_5'Flank|PUF60_uc003yzr.2_Missense_Mutation_p.S336L|PUF60_uc003yzt.2_Missense_Mutation_p.S379L|PUF60_uc003yzq.2_Missense_Mutation_p.S353L|PUF60_uc003yzu.1_Missense_Mutation_p.S385L	NM_078480	NP_510965	Q9UHX1	PUF60_HUMAN	poly-U binding splicing factor 60KDa isoform a	396	Inhibits homodimerization.|Inhibits transcriptional repression, interaction with ERCC3 and apoptosis induction.				apoptosis|mRNA processing|regulation of transcription, DNA-dependent|RNA splicing|transcription, DNA-dependent	nucleus|ribonucleoprotein complex	DNA binding|nucleotide binding|protein binding|RNA binding				0	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			CACTCCCACCGAGGGGATGGT	0.612		NaN											0	0	0	0.009096	0	3	17									
NRBP2	340371	broad.mit.edu	37	8	144921577	144921577	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:144921577G>C	uc011lkt.1	-	6	629	c.489C>G	c.(487-489)TTC>TTG	p.F163L	NRBP2_uc003yzv.2_5'UTR|NRBP2_uc003yzz.1_5'Flank|NRBP2_uc003yzw.2_5'Flank|NRBP2_uc010mfl.2_5'Flank|NRBP2_uc010mfm.2_5'UTR|NRBP2_uc011lks.1_5'UTR|NRBP2_uc003yzy.2_5'UTR	NM_178564	NP_848659	Q9NSY0	NRBP2_HUMAN	nuclear receptor binding protein 2	163	Protein kinase.				negative regulation of neuron apoptosis|neuron differentiation	cytoplasm	ATP binding|protein kinase activity			central_nervous_system(2)	2	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			AGGCGTGCAGGAAGCTGCAGA	0.667		NaN											0	0	0	0.001168	0	5	10									
EPPK1	83481	broad.mit.edu	37	8	144940861	144940861	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:144940861G>A	uc003zaa.1	-	1	6574	c.6561C>T	c.(6559-6561)CTC>CTT	p.L2187L		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	2187						cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGGCTGAGCTGAGGAGTTCAG	0.537		NaN											0	0	0	0.003271	0	26	210									
EPPK1	83481	broad.mit.edu	37	8	144940900	144940900	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:144940900G>C	uc003zaa.1	-	1	6535	c.6522C>G	c.(6520-6522)TTC>TTG	p.F2174L		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	2174						cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TAATTCCTTGGAACCACAGGT	0.527		NaN											0	0	0	0.010504	0	19	166									
EPPK1	83481	broad.mit.edu	37	8	144941013	144941013	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:144941013G>C	uc003zaa.1	-	1	6422	c.6409C>G	c.(6409-6411)CTC>GTC	p.L2137V		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	2137						cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			ACCAGCTGGAGCTTCTTCTCC	0.517		NaN											0	0	0	0.010504	0	19	136									
EPPK1	83481	broad.mit.edu	37	8	144941802	144941802	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr8:144941802G>A	uc003zaa.1	-	1	5633	c.5620C>T	c.(5620-5622)CGT>TGT	p.R1874C		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	1874						cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CTCCCCACACGAAGTGTGTGC	0.607		NaN											0	0	0	0.004482	0	9	36									
SMARCA2	6595	broad.mit.edu	37	9	2054650	2054650	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr9:2054650C>T	uc003zhc.2	+	6	1199	c.1100C>T	c.(1099-1101)TCT>TTT	p.S367F	SMARCA2_uc003zhd.2_Missense_Mutation_p.S367F|SMARCA2_uc010mha.2_Missense_Mutation_p.S358F	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	367					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		CTGCCTGGCTCTTTGCCACCA	0.443		NaN											0	0	0	0.008871	0	17	82									
KIAA2026	158358	broad.mit.edu	37	9	5968412	5968412	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr9:5968412G>A	uc003zjq.3	-	3	2035	c.1819C>T	c.(1819-1821)CCA>TCA	p.P607S		NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	607										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		ATTTCACCTGGACTAAGAGGC	0.363		NaN											0	0	0	0.001984	0	5	74									
C9orf72	203228	broad.mit.edu	37	9	27566843	27566843	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr9:27566843C>T	uc003zqq.2	-	2	373	c.276G>A	c.(274-276)GTG>GTA	p.V92V	C9orf72_uc003zqr.1_Silent_p.V92V	NM_018325	NP_060795	Q96LT7	CI072_HUMAN	hypothetical protein LOC203228 isoform a	92										ovary(3)|central_nervous_system(1)	4		all_neural(11;7.57e-10)		LUSC - Lung squamous cell carcinoma(38;0.0001)|Lung(218;0.00016)		AAACAATAATCACTCCCTTTT	0.378		NaN											0	0	0	0.009096	0	3	39									
NFX1	4799	broad.mit.edu	37	9	33313681	33313681	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr9:33313681C>T	uc003zsq.2	+	7	1539	c.1478C>T	c.(1477-1479)TCA>TTA	p.S493L	SUGT1P1_uc010mjq.1_Intron|NFX1_uc011lnw.1_Missense_Mutation_p.S493L|NFX1_uc003zso.2_Missense_Mutation_p.S493L|NFX1_uc003zsp.1_Missense_Mutation_p.S493L|NFX1_uc010mjr.1_Missense_Mutation_p.S493L|NFX1_uc003zsr.2_Missense_Mutation_p.S493L	NM_002504	NP_002495	Q12986	NFX1_HUMAN	nuclear transcription factor, X-box binding 1	493					inflammatory response|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter	nucleus	DNA binding|ligase activity|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.00506)	GBM - Glioblastoma multiforme(74;0.224)		CAGGCTGTCTCAGTCCACTGT	0.483		NaN											0	0	0	0.012319	0	16	126									
SIGMAR1	10280	broad.mit.edu	37	9	34635839	34635839	+	Silent	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr9:34635839G>A	uc003zvb.2	-	4	536	c.462C>T	c.(460-462)CAC>CAT	p.H154H	SIGMAR1_uc003zva.3_Silent_p.H134H|SIGMAR1_uc003zuz.2_Silent_p.H65H|SIGMAR1_uc003zvc.2_Silent_p.H123H|SIGMAR1_uc003zvd.2_RNA|SIGMAR1_uc011loo.1_Intron	NM_005866	NP_005857	Q99720	SGMR1_HUMAN	sigma non-opioid intracellular receptor 1	154	Cytoplasmic (Potential).				ergosterol biosynthetic process|lipid transport	cell junction|endoplasmic reticulum membrane|growth cone|integral to plasma membrane|lipid particle|nuclear inner membrane|nuclear outer membrane	C-8 sterol isomerase activity|drug binding				0					Dextromethorphan(DB00514)	CACCAGGCCCGTGTACTACCG	0.647		NaN											0	0	0	0.00245	0	11	47									
GNE	10020	broad.mit.edu	37	9	36276902	36276902	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr9:36276902G>A	uc010mli.2	-	1	140	c.40C>T	c.(40-42)CAA>TAA	p.Q14*	CLTA_uc003zzf.1_Intron|GNE_uc010mlj.2_Silent_p.F46F	NM_001128227	NP_001121699	Q9Y223	GLCNE_HUMAN	UDP-N-acetylglucosamine-2-epimerase/N-	Error:Variant_position_missing_in_Q9Y223_after_alignment					cell adhesion|lipopolysaccharide biosynthetic process|N-acetylneuraminate metabolic process|UDP-N-acetylglucosamine metabolic process		ATP binding|N-acylmannosamine kinase activity|UDP-N-acetylglucosamine 2-epimerase activity				0			STAD - Stomach adenocarcinoma(86;0.228)			TGAGGTCCTTGAAAGCATGAC	0.403		NaN											0	0	0	0.014323	0	17	69									
TBC1D2	55357	broad.mit.edu	37	9	100971023	100971023	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr9:100971023C>T	uc011lvb.1	-	9	2257	c.2077G>A	c.(2077-2079)GAC>AAC	p.D693N	TBC1D2_uc004ayp.2_Missense_Mutation_p.D233N|TBC1D2_uc004ayq.2_Missense_Mutation_p.D693N|TBC1D2_uc004ayr.2_Missense_Mutation_p.D475N|TBC1D2_uc004ayo.3_Missense_Mutation_p.D693N	NM_018421	NP_060891	Q9BYX2	TBD2A_HUMAN	TBC1 domain family, member 2	693	Rab-GAP TBC.					cell junction|cytoplasmic membrane-bounded vesicle|nucleus	Rab GTPase activator activity			ovary(3)	3		Myeloproliferative disorder(762;0.0255)		OV - Ovarian serous cystadenocarcinoma(323;2.55e-37)		CGGAGCTTGTCGGGGAAGCTG	0.642		NaN											0	0	0	0.009096	0	4	55									
PTPN3	5774	broad.mit.edu	37	9	112166859	112166859	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr9:112166859C>T	uc004bed.2	-	19	1934	c.1822G>A	c.(1822-1824)GAA>AAA	p.E608K	PTPN3_uc004beb.2_Missense_Mutation_p.E477K|PTPN3_uc004bec.2_Missense_Mutation_p.E432K|PTPN3_uc010mtu.2_RNA|PTPN3_uc011lwg.1_Missense_Mutation_p.E563K|PTPN3_uc011lwh.1_Missense_Mutation_p.E454K|PTPN3_uc011lwd.1_Missense_Mutation_p.E76K|PTPN3_uc011lwe.1_Missense_Mutation_p.E321K|PTPN3_uc011lwf.1_Missense_Mutation_p.E276K	NM_002829	NP_002820	P26045	PTN3_HUMAN	protein tyrosine phosphatase, non-receptor type	608					negative regulation of membrane protein ectodomain proteolysis|negative regulation of mitotic cell cycle	cytoplasm|cytoskeleton|internal side of plasma membrane	ATPase binding|cytoskeletal protein binding|phosphotyrosine binding|protein tyrosine phosphatase activity			ovary(3)	3						agttcatcttcagacttgaag	0.373		NaN											0	0	0	0.004656	0	20	90									
COL27A1	85301	broad.mit.edu	37	9	116973287	116973287	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr9:116973287G>T	uc011lxl.1	+	12	2348	c.2348G>T	c.(2347-2349)AGG>ATG	p.R783M	COL27A1_uc004bii.2_RNA|COL27A1_uc010mvd.1_Missense_Mutation_p.R582M	NM_032888	NP_116277	Q8IZC6	CORA1_HUMAN	collagen, type XXVII, alpha 1 precursor	783	Collagen-like 3.|Pro-rich.|Triple-helical region.				cell adhesion		extracellular matrix structural constituent			ovary(3)|skin(1)	4						CCTGGCAAGAGGGGCAAGATG	0.642		NaN											1	0	2.52707e-12	0.006214	2.77192e-12	6	94									
DFNB31	25861	broad.mit.edu	37	9	117188538	117188538	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr9:117188538C>G	uc004biz.3	-	4	1768	c.1119G>C	c.(1117-1119)AAG>AAC	p.K373N	DFNB31_uc004bix.2_5'Flank|DFNB31_uc004biy.3_5'UTR|DFNB31_uc004bja.3_Missense_Mutation_p.K373N	NM_015404	NP_056219	Q9P202	WHRN_HUMAN	CASK-interacting protein CIP98 isoform 1	373					inner ear receptor stereocilium organization|retina homeostasis|sensory perception of light stimulus|sensory perception of sound	cytoplasm|growth cone|stereocilium				ovary(4)|central_nervous_system(1)|pancreas(1)	6						TGGCGATCCACTTGGTCTCGT	0.617		NaN											0	0	0	0.001984	0	6	54									
STRBP	55342	broad.mit.edu	37	9	125909232	125909232	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr9:125909232G>T	uc004bns.2	-	13	1670	c.1240C>A	c.(1240-1242)CAT>AAT	p.H414N	STRBP_uc004bnt.2_Missense_Mutation_p.H232N|STRBP_uc004bnu.2_Missense_Mutation_p.H400N|STRBP_uc004bnv.2_Missense_Mutation_p.H414N|STRBP_uc004bnr.2_Missense_Mutation_p.H26N	NM_018387	NP_060857	Q96SI9	STRBP_HUMAN	spermatid perinuclear RNA binding protein	414	DRBM 1.				multicellular organismal development	cytoplasm|nucleus	DNA binding			breast(1)|skin(1)	2						ACTGGGGCATGAACGGGGCCA	0.463		NaN											1	0	3.27435e-08	0.00245	3.53984e-08	13	114									
DOLK	22845	broad.mit.edu	37	9	131709575	131709575	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr9:131709575C>T	uc004bwr.2	-	1	438	c.8G>A	c.(7-9)CGA>CAA	p.R3Q	NUP188_uc004bws.1_5'Flank|NUP188_uc004bwq.1_Intron	NM_014908	NP_055723	Q9UPQ8	DOLK_HUMAN	dolichol kinase	3	Lumenal (Potential).				dolichyl diphosphate biosynthetic process|dolichyl monophosphate biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to endoplasmic reticulum membrane|membrane fraction	dolichol kinase activity				0						TGGGCACTCTCGGGTCATATC	0.662		NaN											0	0	0	0.001855	0	10	53									
RPS6KA3	6197	broad.mit.edu	37	X	20194392	20194392	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chrX:20194392C>G	uc004czu.2	-	13	1078	c.1078G>C	c.(1078-1080)GAG>CAG	p.E360Q	RPS6KA3_uc011mjk.1_Missense_Mutation_p.E331Q|RPS6KA3_uc004czv.2_Missense_Mutation_p.E348Q|RPS6KA3_uc011mjl.1_Missense_Mutation_p.E332Q|RPS6KA3_uc011mjm.1_Missense_Mutation_p.E332Q	NM_004586	NP_004577	P51812	KS6A3_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	360	AGC-kinase C-terminal.				axon guidance|central nervous system development|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|skeletal system development|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(4)|stomach(1)|ovary(1)|lung(1)|breast(1)	8						GCAGTAAACTCAGGATCAAAA	0.348		NaN											0	0	0	0.000602	0	4	21									
TAB3	257397	broad.mit.edu	37	X	30872614	30872614	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chrX:30872614G>A	uc004dcj.2	-	6	1831	c.1168C>T	c.(1168-1170)CAA>TAA	p.Q390*	TAB3_uc004dck.2_Nonsense_Mutation_p.Q390*|TAB3_uc010ngl.2_Nonsense_Mutation_p.Q390*	NM_152787	NP_690000	Q8N5C8	TAB3_HUMAN	mitogen-activated protein kinase kinase kinase 7	390	Pro-rich.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein binding|zinc ion binding			ovary(1)	1						GGAGATGGTTGATTACTGATG	0.423		NaN											0	0	0	0.001168	0	4	73									
BMP15	9210	broad.mit.edu	37	X	50659572	50659572	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chrX:50659572G>A	uc011mnw.1	+	2	1144	c.1144G>A	c.(1144-1146)GAG>AAG	p.E382K		NM_005448	NP_005439	O95972	BMP15_HUMAN	bone morphogenetic protein 15 precursor	382					female gamete generation|granulosa cell development|ovarian follicle development	extracellular space	cytokine activity|growth factor activity			ovary(2)	2	Ovarian(276;0.236)					CAAGGAGTATGAGGGTATGAT	0.453		NaN											0	0	0	0.00308	0	7	63									
XAGE5	170627	broad.mit.edu	37	X	52844216	52844216	+	Silent	SNP	A	A	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chrX:52844216A>C	uc004drd.1	+	4	344	c.279A>C	c.(277-279)TCA>TCC	p.S93S		NM_130775	NP_570131	Q8WWM1	GAGD5_HUMAN	X antigen family, member 5	93										ovary(1)	1						TGCCAAAATCAGAGCAATTTA	0.388		NaN											0	0	0	0.004482	0	7	22									
HUWE1	10075	broad.mit.edu	37	X	53578272	53578272	+	Silent	SNP	C	C	G			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chrX:53578272C>G	uc004dsp.2	-	64	9453	c.9051G>C	c.(9049-9051)GTG>GTC	p.V3017V	HUWE1_uc004dsn.2_Intron	NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	3017					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						ACTCAGGGCTCACTTCAGTCA	0.597		NaN											0	0	0	0.000602	0	4	9									
RLIM	51132	broad.mit.edu	37	X	73814150	73814150	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chrX:73814150C>T	uc004ebu.2	-	4	534	c.244G>A	c.(244-246)GAA>AAA	p.E82K	RLIM_uc004ebw.2_Missense_Mutation_p.E82K	NM_183353	NP_899196	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	82					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						CCTCTATTTTCATCTGAGTTT	0.418		NaN											0	0	0	0.000602	0	5	29									
ABCB7	22	broad.mit.edu	37	X	74291394	74291394	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chrX:74291394C>A	uc004eca.2	-	9	1182	c.1157G>T	c.(1156-1158)AGT>ATT	p.S386I	ABCB7_uc004ebz.2_Missense_Mutation_p.S387I|ABCB7_uc011mqn.1_Missense_Mutation_p.S360I|ABCB7_uc010nls.2_Missense_Mutation_p.S347I|ABCB7_uc010nlt.2_Missense_Mutation_p.S346I	NM_004299	NP_004290	O75027	ABCB7_HUMAN	ATP-binding cassette, sub-family B, member 7	386	ABC transmembrane type-1.|Helical; (Potential).				cellular iron ion homeostasis	integral to membrane|mitochondrial inner membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|heme transporter activity			ovary(1)	1						TAAACCGACACTGAAAATAGC	0.408		NaN											1	0	0.00909568	0.009096	0.00928131	4	63									
GPRASP1	9737	broad.mit.edu	37	X	101912847	101912847	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chrX:101912847C>T	uc004ejj.3	+	5	4807	c.4006C>T	c.(4006-4008)CAA>TAA	p.Q1336*	GPRASP1_uc004eji.3_Nonsense_Mutation_p.Q1336*|GPRASP1_uc010nod.2_Nonsense_Mutation_p.Q1336*	NM_014710	NP_055525	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting	1336	OPRD1-binding.					cytoplasm	protein binding			ovary(1)|lung(1)	2						TGACAATATTCAAATTGTTCT	0.328		NaN											0	0	0	0.004482	0	7	32									
BEX4	56271	broad.mit.edu	37	X	102471435	102471435	+	Silent	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chrX:102471435C>T	uc004ejv.3	+	3	589	c.354C>T	c.(352-354)CTC>CTT	p.L118L	BEX4_uc004ejw.3_Silent_p.L118L	NM_001080425	NP_001073894	Q9NWD9	BEX4_HUMAN	BEX family member 4	118						cytoplasm|nucleus				skin(1)	1						ACTTTTGCCTCATACCTTGAA	0.398		NaN											0	0	0	0.003163	0	13	58									
ESX1	80712	broad.mit.edu	37	X	103499470	103499470	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chrX:103499470C>T	uc004ely.2	-	1	119	c.61G>A	c.(61-63)GAG>AAG	p.E21K		NM_153448	NP_703149	Q8N693	ESX1_HUMAN	extraembryonic, spermatogenesis, homeobox	21					negative regulation of transcription, DNA-dependent|regulation of cell cycle	cytoplasm|nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TCGATGTCCTCGCCGACTGCC	0.552		NaN											0	0	0	0.008291	0	7	157									
SERPINA7	6906	broad.mit.edu	37	X	105281023	105281023	+	Silent	SNP	G	G	C			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chrX:105281023G>C	uc004eme.1	-	1	43	c.27C>G	c.(25-27)CTC>CTG	p.L9L	SERPINA7_uc010npd.2_Silent_p.L9L|SERPINA7_uc010npe.1_Silent_p.L9L	NM_000354	NP_000345	P05543	THBG_HUMAN	serine (or cysteine) proteinase inhibitor, clade	9					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity				0					Levothyroxine(DB00451)|Liothyronine(DB00279)	CAAGTACCAAGAGAACCAGAT	0.448		NaN											0	0	0	0.001855	0	12	38									
SLITRK4	139065	broad.mit.edu	37	X	142718202	142718202	+	Silent	SNP	G	G	T			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chrX:142718202G>T	uc004fbx.2	-	2	1099	c.723C>A	c.(721-723)ATC>ATA	p.I241I	SLITRK4_uc004fby.2_Silent_p.I241I	NM_173078	NP_775101	Q8IW52	SLIK4_HUMAN	slit and trk like 4 protein precursor	241	Extracellular (Potential).|LRRCT 1.					integral to membrane				upper_aerodigestive_tract(1)|large_intestine(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					GAGTTTCACAGATAGCTTCTC	0.433		NaN											1	0	1.12685e-05	0.004482	1.19034e-05	7	18									
ARID1A	8289	broad.mit.edu	37	1	27092815	27092815	+	Frame_Shift_Del	DEL	C	C	-			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08			C	-	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr1:27092815delC	uc001bmv.1	+	9	3209	c.2836delC	c.(2836-2838)CCCfs	p.P946fs	ARID1A_uc001bmt.1_Frame_Shift_Del_p.P946fs|ARID1A_uc001bmu.1_Frame_Shift_Del_p.P946fs|ARID1A_uc001bmw.1_Frame_Shift_Del_p.P563fs	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	946					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		CCCTCAGGGACCCCCATATTC	0.483		NaN	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								NaN	NaN	NaN	NaN	NaN	18	129	---	---							
TM9SF3	56889	broad.mit.edu	37	10	98336475	98336475	+	Frame_Shift_Del	DEL	T	T	-			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr10:98336475delT	uc001kmm.3	-	2	431	c.214delA	c.(214-216)AGTfs	p.S72fs	TM9SF3_uc010qot.1_Frame_Shift_Del_p.S72fs	NM_020123	NP_064508	Q9HD45	TM9S3_HUMAN	transmembrane 9 superfamily member 3 precursor	72						integral to membrane	binding				0		Colorectal(252;0.158)		Epithelial(162;1.84e-09)|all cancers(201;2.84e-08)		TGACTGATACTTTTTTTTGAC	0.363		NaN											NaN	NaN	NaN	NaN	NaN	8	150	---	---							
IQSEC3	440073	broad.mit.edu	37	12	248252	248254	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr12:248252_248254delGAG	uc001qhw.1	+	1	820_822	c.814_816delGAG	c.(814-816)GAGdel	p.E276del	IQSEC3_uc001qhu.1_In_Frame_Del_p.E276del|IQSEC3_uc001qht.1_In_Frame_Del_p.E361del|uc001qhv.1_Intron	NM_015232	NP_056047	Q9UPP2	IQEC3_HUMAN	IQ motif and Sec7 domain 3	579	Poly-Glu.				regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity			central_nervous_system(2)|large_intestine(1)|skin(1)	4	all_cancers(10;0.016)|all_lung(10;0.0222)|all_epithelial(11;0.0262)|Lung NSC(10;0.031)		OV - Ovarian serous cystadenocarcinoma(31;0.00456)	LUAD - Lung adenocarcinoma(1;0.172)|Lung(1;0.179)		Agaggaggaagaggaggaggagg	0.586		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---							
RNF17	56163	broad.mit.edu	37	13	25419163	25419163	+	Frame_Shift_Del	DEL	A	A	-			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr13:25419163delA	uc001upr.2	+	22	3088	c.3047delA	c.(3046-3048)GAAfs	p.E1016fs	RNF17_uc010tdd.1_Frame_Shift_Del_p.E875fs|RNF17_uc010aab.2_RNA|RNF17_uc010tde.1_Frame_Shift_Del_p.E1016fs|RNF17_uc001ups.2_Frame_Shift_Del_p.E955fs|RNF17_uc010aac.2_Frame_Shift_Del_p.E214fs|RNF17_uc010aad.2_Frame_Shift_Del_p.E68fs	NM_031277	NP_112567	Q9BXT8	RNF17_HUMAN	ring finger protein 17	1016	Tudor 2.				multicellular organismal development	cytoplasm|nucleus	hydrolase activity, acting on ester bonds|nucleic acid binding|zinc ion binding			ovary(1)|skin(1)	2		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0114)|OV - Ovarian serous cystadenocarcinoma(117;0.0311)|Epithelial(112;0.0524)		AAACTTGAAGAAAATCTAAAG	0.303		NaN											NaN	NaN	NaN	NaN	NaN	18	118	---	---							
GSX1	219409	broad.mit.edu	37	13	28367927	28367929	+	In_Frame_Del	DEL	GGC	GGC	-			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr13:28367927_28367929delGGC	uc001urr.1	+	2	685_687	c.637_639delGGC	c.(637-639)GGCdel	p.G218del		NM_145657	NP_663632	Q9H4S2	GSX1_HUMAN	GS homeobox 1	218	Poly-Gly.				positive regulation of transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Lung SC(185;0.0161)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	GBM - Glioblastoma multiforme(144;0.0402)|all cancers(112;0.0404)|OV - Ovarian serous cystadenocarcinoma(117;0.197)		CAACCATCgtggcggcggcggcg	0.463		NaN											NaN	NaN	NaN	NaN	NaN	7	93	---	---							
SIPA1L1	26037	broad.mit.edu	37	14	72190482	72190484	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr14:72190482_72190484delTCC	uc001xms.2	+	16	4738_4740	c.4390_4392delTCC	c.(4390-4392)TCCdel	p.S1468del	SIPA1L1_uc001xmt.2_In_Frame_Del_p.S1447del|SIPA1L1_uc001xmu.2_In_Frame_Del_p.S1447del|SIPA1L1_uc001xmv.2_In_Frame_Del_p.S1468del|SIPA1L1_uc010ttm.1_In_Frame_Del_p.S922del|SIPA1L1_uc001xmw.2_In_Frame_Del_p.S233del	NM_015556	NP_056371	O43166	SI1L1_HUMAN	signal-induced proliferation-associated 1 like	1468	Ser-rich.				actin cytoskeleton reorganization|activation of Rap GTPase activity|regulation of dendritic spine morphogenesis	cell junction|cytoplasm|dendritic spine|postsynaptic density|postsynaptic membrane|synaptosome	GTPase activator activity			ovary(3)|breast(1)	4				all cancers(60;0.00169)|BRCA - Breast invasive adenocarcinoma(234;0.00912)|OV - Ovarian serous cystadenocarcinoma(108;0.0109)		ctcctcctcttcctcctcctcct	0.468		NaN											NaN	NaN	NaN	NaN	NaN	7	167	---	---							
C19orf55	148137	broad.mit.edu	37	19	36255947	36255949	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr19:36255947_36255949delCTC	uc002obq.1	+	7	712_714	c.639_641delCTC	c.(637-642)ATCTCC>ATC	p.S218del		NM_001039887	NP_001034976	Q2NL68	CS055_HUMAN	hypothetical protein LOC148137	218	Ser-rich.									ovary(1)	1	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			AAGCCTCCATCTCCTCCTCCTCC	0.631		NaN											NaN	NaN	NaN	NaN	NaN	8	402	---	---							
RBCK1	10616	broad.mit.edu	37	20	401519	401521	+	In_Frame_Del	DEL	AGC	AGC	-			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr20:401519_401521delAGC	uc002wdp.3	+	7	1454_1456	c.761_763delAGC	c.(760-765)AAGCAG>AAG	p.Q258del	RBCK1_uc010zpm.1_Intron|RBCK1_uc002wdq.3_In_Frame_Del_p.Q216del|RBCK1_uc010fzy.2_RNA|RBCK1_uc002wdr.3_Intron	NM_031229	NP_112506	Q9BYM8	HOIL1_HUMAN	RanBP-type and C3HC4-type zinc finger containing	258	Potential.|Interaction with TAB2.				interspecies interaction between organisms|negative regulation of NF-kappaB transcription factor activity|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|proteasomal ubiquitin-dependent protein catabolic process|protein linear polyubiquitination|T cell receptor signaling pathway	LUBAC complex	protein binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0		all_epithelial(17;0.172)|Lung NSC(37;0.191)|Breast(17;0.231)				GCCCAGCGGAAGCAGCAGCAGCA	0.729		NaN											NaN	NaN	NaN	NaN	NaN	2	4	---	---							
TBC1D23	55773	broad.mit.edu	37	3	100039735	100039736	+	Frame_Shift_Ins	INS	-	-	A			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr3:100039735_100039736insA	uc003dtt.2	+	18	2115_2116	c.1938_1939insA	c.(1936-1941)TCCAAAfs	p.S646fs	TBC1D23_uc003dts.2_Frame_Shift_Ins_p.S631fs|TBC1D23_uc003dtu.2_Frame_Shift_Ins_p.S77fs	NM_018309	NP_060779	Q9NUY8	TBC23_HUMAN	TBC1 domain family, member 23	646_647						intracellular	Rab GTPase activator activity			ovary(1)|liver(1)	2						AAATTACATCCAAAAAAAAACA	0.356		NaN											NaN	NaN	NaN	NaN	NaN	8	78	---	---							
UBE2K	3093	broad.mit.edu	37	4	39779392	39779392	+	Frame_Shift_Del	DEL	A	A	-			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr4:39779392delA	uc003guu.3	+	6	774	c.490delA	c.(490-492)AAAfs	p.K164fs	UBE2K_uc003gus.3_Intron|UBE2K_uc003gut.3_Frame_Shift_Del_p.K113fs|UBE2K_uc010ifn.2_RNA|UBE2K_uc011byq.1_Frame_Shift_Del_p.K103fs|UBE2K_uc003guq.3_Frame_Shift_Del_p.K61fs	NM_005339	NP_005330	P61086	UBE2K_HUMAN	ubiquitin-conjugating enzyme E2K isoform 1	164	UBA.				protein K48-linked ubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm	ATP binding|ubiquitin protein ligase binding|ubiquitin-ubiquitin ligase activity			ovary(1)	1						AGAATACACCAAAAAAATAGA	0.363		NaN											NaN	NaN	NaN	NaN	NaN	7	122	---	---							
NRG2	9542	broad.mit.edu	37	5	139422565	139422567	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr5:139422565_139422567delGCT	uc003lex.1	-	1	313_315	c.88_90delAGC	c.(88-90)AGCdel	p.S30del	NRG2_uc003lev.1_In_Frame_Del_p.S30del|NRG2_uc003lew.1_In_Frame_Del_p.S30del|NRG2_uc003ley.1_In_Frame_Del_p.S30del	NM_004883	NP_004874	O14511	NRG2_HUMAN	neuregulin 2 isoform 1	30	Poly-Ser.				embryo development	extracellular region|integral to membrane|plasma membrane	growth factor activity			pancreas(2)|breast(2)|ovary(1)|skin(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			tgctcctctcgctgctgctgctg	0.32		NaN											NaN	NaN	NaN	NaN	NaN	4	3	---	---							
IFNGR1	3459	broad.mit.edu	37	6	137519505	137519506	+	Frame_Shift_Del	DEL	CT	CT	-			TCGA-DK-A3IU-01A-11D-A20D-08	TCGA-DK-A3IU-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	52de410f-3ce3-4ee6-87f3-8ec2e829962f	d261214a-bf85-4af6-936a-9350303517bb	g.chr6:137519505_137519506delCT	uc003qho.2	-	7	1235_1236	c.1132_1133delAG	c.(1132-1134)AGTfs	p.S378fs	IFNGR1_uc011edm.1_Frame_Shift_Del_p.S350fs	NM_000416	NP_000407	P15260	INGR1_HUMAN	interferon gamma receptor 1 precursor	378	Cytoplasmic (Potential).				regulation of interferon-gamma-mediated signaling pathway|response to virus	integral to plasma membrane	interferon-gamma receptor activity			upper_aerodigestive_tract(1)	1	Colorectal(23;0.24)			GBM - Glioblastoma multiforme(68;0.000829)|OV - Ovarian serous cystadenocarcinoma(155;0.00389)	Interferon gamma-1b(DB00033)	AGGTGAAGAACTCTCTCTCTCT	0.431		NaN											NaN	NaN	NaN	NaN	NaN	8	145	---	---							
