Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
RERE	473	broad.mit.edu	37	1	8419925	8419925	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr1:8419925C>T	uc001ape.2	-	20	4327	c.3517G>A	c.(3517-3519)GAG>AAG	p.E1173K	RERE_uc001apf.2_Missense_Mutation_p.E1173K|RERE_uc001apd.2_Missense_Mutation_p.E619K	NM_012102	NP_036234	Q9P2R6	RERE_HUMAN	atrophin-1 like protein isoform a	1173	Potential.				multicellular organismal development|NLS-bearing substrate import into nucleus	mitochondrion	poly-glutamine tract binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2	Ovarian(185;0.0661)	all_epithelial(116;1.17e-21)|all_lung(118;1.4e-06)|Lung NSC(185;3.06e-06)|Renal(390;0.000147)|Breast(348;0.000206)|Colorectal(325;0.00187)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;9.64e-67)|GBM - Glioblastoma multiforme(8;9.89e-33)|Colorectal(212;1.45e-07)|COAD - Colon adenocarcinoma(227;3.42e-05)|Kidney(185;6e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000533)|KIRC - Kidney renal clear cell carcinoma(229;0.00106)|STAD - Stomach adenocarcinoma(132;0.00118)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.195)		TGCTCAGCCTCGCGCTTGGCC	0.498		NaN											0	0	0	0.02938	0	4	58									
DEM1	64789	broad.mit.edu	37	1	40980423	40980423	+	Missense_Mutation	SNP	A	A	G			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr1:40980423A>G	uc001cfp.2	+	3	412	c.207A>G	c.(205-207)ATA>ATG	p.I69M	DEM1_uc001cfq.2_Missense_Mutation_p.I69M|DEM1_uc001cfr.2_Missense_Mutation_p.I69M|DEM1_uc001cfs.2_Missense_Mutation_p.I69M	NM_022774	NP_073611	Q9H790	EXO5_HUMAN	defects in morphology 1 homolog	69							DNA binding|exonuclease activity				0						GATTGGATATATTATCACCCA	0.423		NaN											0	0	0	0.004672	0	3	100									
NBPF10	100132406	broad.mit.edu	37	1	145302714	145302714	+	Silent	SNP	A	A	G	rs9424867		TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr1:145302714A>G	uc001end.3	+	8	1187	c.1152A>G	c.(1150-1152)TTA>TTG	p.L384L	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_Intron|NBPF10_uc010oyi.1_5'UTR|NBPF10_uc001emq.1_Silent_p.L113L	NM_001039703	NP_001034792	A6NDV3	A6NDV3_HUMAN	hypothetical protein LOC100132406	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment											0	all_hematologic(923;0.032)			Colorectal(1306;1.36e-07)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)		AGGAGAAGTTACGGGAAGGGA	0.527		NaN											0	0	0	0.038147	0	7	38									
PI4KB	5298	broad.mit.edu	37	1	151288629	151288629	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr1:151288629G>A	uc001ext.2	-	2	744	c.329C>T	c.(328-330)TCA>TTA	p.S110L	PI4KB_uc001exr.2_Missense_Mutation_p.S122L|PI4KB_uc001exs.2_Missense_Mutation_p.S110L|PI4KB_uc001exu.2_Missense_Mutation_p.S110L|PI4KB_uc010pcw.1_Intron|PI4KB_uc009wmq.1_Missense_Mutation_p.S122L	NM_002651	NP_002642	Q9UBF8	PI4KB_HUMAN	catalytic phosphatidylinositol 4-kinase beta	110					phosphatidylinositol biosynthetic process|phosphatidylinositol-mediated signaling|receptor-mediated endocytosis	endosome|Golgi apparatus|mitochondrial outer membrane|perinuclear region of cytoplasm|rough endoplasmic reticulum membrane	1-phosphatidylinositol 4-kinase activity|ATP binding|protein binding			ovary(2)|skin(2)	4	Lung SC(34;0.00471)|Ovarian(49;0.0147)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			GGCTGTGCCTGAGGCCACAGC	0.542		NaN											0	0	0	0.058154	0	8	104									
FCGR2A	2212	broad.mit.edu	37	1	161487799	161487799	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr1:161487799G>C	uc001gan.2	+	7	868	c.815G>C	c.(814-816)AGA>ACA	p.R272T	FCGR2A_uc001gam.2_Missense_Mutation_p.R271T|FCGR2A_uc001gao.2_RNA	NM_001136219	NP_001129691	P12318	FCG2A_HUMAN	Fc fragment of IgG, low affinity IIa, receptor	272	Cytoplasmic (Potential).					integral to membrane|plasma membrane	IgG binding|receptor activity			ovary(1)	1	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	atcagaaagagacaacttgaa	0.209		NaN											0	0	0	0.021553	0	6	64									
ATF6	22926	broad.mit.edu	37	1	161821558	161821558	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr1:161821558G>A	uc001gbr.2	+	11	1433	c.1366G>A	c.(1366-1368)GAA>AAA	p.E456K	ATF6_uc001gbq.1_Missense_Mutation_p.E456K	NM_007348	NP_031374	P18850	ATF6A_HUMAN	activating transcription factor 6	456	Lumenal (Potential).				positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response|protein folding	endoplasmic reticulum membrane|Golgi membrane|integral to membrane|nuclear envelope|nucleoplasm	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(2)|skin(1)	3	all_hematologic(112;0.156)		BRCA - Breast invasive adenocarcinoma(70;0.00953)			GGTGCTAACTGAAGAACCATT	0.383		NaN											0	0	0	0.047766	0	7	208									
PAPPA2	60676	broad.mit.edu	37	1	176679172	176679172	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr1:176679172G>C	uc001gkz.2	+	11	4675	c.3511G>C	c.(3511-3513)GAG>CAG	p.E1171Q	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1171					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						TGAACCTTTTGAGAGAAAAAC	0.428		NaN											0	0	0	0.069234	0	8	128									
SOAT1	6646	broad.mit.edu	37	1	179308589	179308589	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr1:179308589G>A	uc001gml.2	+	6	469	c.406G>A	c.(406-408)GAC>AAC	p.D136N	SOAT1_uc010pni.1_Missense_Mutation_p.D71N|SOAT1_uc001gmm.2_Missense_Mutation_p.D78N|SOAT1_uc010pnj.1_5'UTR|SOAT1_uc010pnk.1_Missense_Mutation_p.D71N	NM_003101	NP_003092	P35610	SOAT1_HUMAN	sterol O-acyltransferase 1	136					cholesterol efflux|cholesterol esterification|cholesterol homeostasis|cholesterol metabolic process|cholesterol storage|macrophage derived foam cell differentiation|positive regulation of amyloid precursor protein biosynthetic process|very-low-density lipoprotein particle assembly	endoplasmic reticulum membrane|integral to membrane|microsome	cholesterol binding|cholesterol O-acyltransferase activity|fatty-acyl-CoA binding			central_nervous_system(1)|skin(1)	2					Ezetimibe(DB00973)|Hesperetin(DB01094)	GCTTGAAGTGGACCACATCAG	0.313		NaN											0	0	0	0.038147	0	5	125									
HEATR1	55127	broad.mit.edu	37	1	236766632	236766632	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr1:236766632C>G	uc001hyd.1	-	3	312	c.187G>C	c.(187-189)GAG>CAG	p.E63Q	HEATR1_uc001hye.1_Missense_Mutation_p.E63Q	NM_018072	NP_060542	Q9H583	HEAT1_HUMAN	protein BAP28	63					rRNA processing	nucleolus|ribonucleoprotein complex	protein binding			ovary(2)|skin(1)	3	Ovarian(103;0.0634)|Breast(184;0.133)	all_cancers(173;0.0255)|Prostate(94;0.175)	OV - Ovarian serous cystadenocarcinoma(106;0.00117)			TCAAACTGCTCAAAGGAAGGA	0.393		NaN											0	0	0	0.004672	0	3	95									
KIAA1217	56243	broad.mit.edu	37	10	24762442	24762442	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr10:24762442G>A	uc001iru.3	+	6	1535	c.1132G>A	c.(1132-1134)GAC>AAC	p.D378N	KIAA1217_uc001irs.2_Missense_Mutation_p.D298N|KIAA1217_uc001irt.3_Missense_Mutation_p.D378N|KIAA1217_uc010qcy.1_Missense_Mutation_p.D378N|KIAA1217_uc010qcz.1_Missense_Mutation_p.D378N|KIAA1217_uc001irv.1_Missense_Mutation_p.D228N|KIAA1217_uc010qda.1_RNA|KIAA1217_uc001irw.2_Missense_Mutation_p.D96N|KIAA1217_uc001irz.2_Missense_Mutation_p.D96N|KIAA1217_uc001irx.2_Missense_Mutation_p.D96N|KIAA1217_uc001iry.2_Missense_Mutation_p.D96N	NM_019590	NP_062536	Q5T5P2	SKT_HUMAN	sickle tail isoform 1	378					embryonic skeletal system development	cytoplasm				ovary(5)|skin(2)	7						GCCTGATGAAGACATGAGTGG	0.493		NaN											0	0	0	0.038147	0	7	161									
ANO9	338440	broad.mit.edu	37	11	431763	431763	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr11:431763T>C	uc001lpi.2	-	7	555	c.470A>G	c.(469-471)GAG>GGG	p.E157G	ANO9_uc001lph.2_5'Flank|ANO9_uc010qvv.1_Missense_Mutation_p.E13G	NM_001012302	NP_001012302	A1A5B4	ANO9_HUMAN	tumor protein p53 inducible protein 5	157	Cytoplasmic (Potential).					chloride channel complex	chloride channel activity			central_nervous_system(2)|ovary(1)|skin(1)	4						CAGGCGTCCCTCCCCCTGGCT	0.647		NaN											0	0	0	0.004672	0	3	57									
GANAB	23193	broad.mit.edu	37	11	62407194	62407194	+	Silent	SNP	C	C	G			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr11:62407194C>G	uc001nub.2	-	2	81	c.48G>C	c.(46-48)GCG>GCC	p.A16A	GANAB_uc001nua.2_Silent_p.A16A|GANAB_uc001nuc.2_5'UTR|GANAB_uc010rma.1_Intron|GANAB_uc010rmb.1_Intron	NM_198334	NP_938148	Q14697	GANAB_HUMAN	neutral alpha-glucosidase AB isoform 2	16					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5						GTACCAAAGACGCCCAAGACC	0.473		NaN											0	0	0	0.004672	0	3	89									
PCF11	51585	broad.mit.edu	37	11	82877510	82877510	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr11:82877510C>G	uc001ozx.3	+	5	1916	c.1571C>G	c.(1570-1572)TCT>TGT	p.S524C	PCF11_uc010rsu.1_Missense_Mutation_p.S524C	NM_015885	NP_056969	O94913	PCF11_HUMAN	pre-mRNA cleavage complex II protein Pcf11	524					mRNA 3'-end processing|mRNA cleavage|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	mRNA cleavage factor complex				ovary(1)	1						ATTCGCCAATCTGGAGCTAAG	0.443		NaN											0	0	0	0.02938	0	6	140									
SIK2	23235	broad.mit.edu	37	11	111558730	111558730	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr11:111558730C>G	uc001plt.2	+	4	440	c.322C>G	c.(322-324)CTT>GTT	p.L108V		NM_015191	NP_056006	Q9H0K1	SIK2_HUMAN	SNF1-like kinase 2	108	Protein kinase.				intracellular protein kinase cascade|regulation of insulin receptor signaling pathway	Golgi apparatus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity			central_nervous_system(2)|skin(1)	3						TACAGACTATCTTGCTAATCA	0.368		NaN											0	0	0	0.021553	0	4	91									
KDM5A	5927	broad.mit.edu	37	12	417057	417057	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr12:417057T>C	uc001qif.1	-	23	3856	c.3493A>G	c.(3493-3495)ATT>GTT	p.I1165V	KDM5A_uc001qie.1_Missense_Mutation_p.I1165V	NM_001042603	NP_001036068	P29375	KDM5A_HUMAN	retinoblastoma binding protein 2 isoform 1	1165	PHD-type 2.				chromatin modification|multicellular organismal development|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	cytoplasm|nucleolus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|ovary(1)	3						TTGCGGCAAATGCAAAATTTT	0.453		NaN	T 	NUP98	AML								0	0	0	0.038147	0	7	163									
DDX23	9416	broad.mit.edu	37	12	49230553	49230553	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr12:49230553C>G	uc001rsm.2	-	10	1126	c.1035G>C	c.(1033-1035)AAG>AAC	p.K345N		NM_004818	NP_004809	Q9BUQ8	DDX23_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 23	345						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent RNA helicase activity|nucleic acid binding|protein binding			kidney(3)|ovary(1)|lung(1)|skin(1)	6						TGGCTTCCTTCTTACGAAGTT	0.532		NaN											0	0	0	0.069234	0	10	236									
UHRF1BP1L	23074	broad.mit.edu	37	12	100476855	100476855	+	Nonsense_Mutation	SNP	G	G	C			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr12:100476855G>C	uc001tgq.2	-	11	1575	c.1346C>G	c.(1345-1347)TCA>TGA	p.S449*	UHRF1BP1L_uc001tgr.2_Nonsense_Mutation_p.S449*|UHRF1BP1L_uc001tgp.2_Nonsense_Mutation_p.S99*	NM_015054	NP_055869	A0JNW5	UH1BL_HUMAN	UHRF1 (ICBP90) binding protein 1-like isoform a	449										ovary(2)	2						CTTAGCTTTTGATTGTTGAGA	0.338		NaN											0	0	0	0.014758	0	4	81									
SACS	26278	broad.mit.edu	37	13	23905175	23905175	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr13:23905175G>C	uc001uon.2	-	10	13429	c.12840C>G	c.(12838-12840)TTC>TTG	p.F4280L	SACS_uc001uoo.2_Missense_Mutation_p.F4133L|SACS_uc001uop.1_Intron|SACS_uc001uoq.1_Intron	NM_014363	NP_055178	Q9NZJ4	SACS_HUMAN	sacsin	4280					cell death|negative regulation of inclusion body assembly|protein folding	axon|cell body fiber|dendrite|mitochondrion|nucleus	ATP binding|chaperone binding|Hsp70 protein binding|proteasome binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		all_cancers(29;1.51e-22)|all_epithelial(30;7.82e-19)|all_lung(29;4.71e-18)|Lung SC(185;0.0225)|Breast(139;0.128)		all cancers(112;0.00197)|Epithelial(112;0.00854)|OV - Ovarian serous cystadenocarcinoma(117;0.0298)|Lung(94;0.189)		CTCTACCAGAGAAAAGAGGAG	0.478		NaN											0	0	0	0.014758	0	4	93									
CDK8	1024	broad.mit.edu	37	13	26911762	26911762	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr13:26911762G>A	uc001uqr.1	+	2	213	c.187G>A	c.(187-189)GCA>ACA	p.A63T	CDK8_uc001uqs.1_Missense_Mutation_p.A63T|CDK8_uc001uqt.1_5'UTR	NM_001260	NP_001251	P49336	CDK8_HUMAN	cyclin-dependent kinase 8	63	Protein kinase.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mediator complex	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			lung(2)|large_intestine(1)|ovary(1)|skin(1)	5	Colorectal(5;0.000442)	Lung SC(185;0.0156)|Breast(139;0.147)		all cancers(112;0.0384)|Epithelial(112;0.142)|OV - Ovarian serous cystadenocarcinoma(117;0.188)		CTCTATGTCGGCATGTAGAGA	0.284		NaN											0	0	0	0.02938	0	4	138									
PAN3	255967	broad.mit.edu	37	13	28794450	28794450	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr13:28794450C>T	uc001urz.2	+	5	505	c.497C>T	c.(496-498)TCT>TTT	p.S166F	PAN3_uc010tdo.1_Missense_Mutation_p.S312F|PAN3_uc001ury.2_5'UTR|PAN3_uc001urx.2_Missense_Mutation_p.S112F	NM_175854	NP_787050	Q58A45	PAN3_HUMAN	PABP1-dependent poly A-specific ribonuclease	312	Interaction with polyadenylate-binding protein.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening	centrosome|cytosol	ATP binding|protein kinase activity			ovary(1)	1	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)	Colorectal(13;0.000334)	all cancers(112;0.0102)|Epithelial(112;0.0803)|GBM - Glioblastoma multiforme(144;0.121)|OV - Ovarian serous cystadenocarcinoma(117;0.13)|Lung(94;0.174)		TCAAATATGTCTGCCTTCTCT	0.438		NaN											0	0	0	0.038147	0	8	308									
NFKBIA	4792	broad.mit.edu	37	14	35871254	35871254	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr14:35871254C>T	uc001wtf.3	-	6	1029	c.919G>A	c.(919-921)GAC>AAC	p.D307N	NFKBIA_uc001wte.3_Missense_Mutation_p.D217N|NFKBIA_uc001wtg.3_Missense_Mutation_p.D264N|NFKBIA_uc010amo.2_RNA	NM_020529	NP_065390	P25963	IKBA_HUMAN	nuclear factor of kappa light polypeptide gene	307					anti-apoptosis|apoptosis|cellular response to cold|cytoplasmic sequestering of NF-kappaB|innate immune response|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of DNA binding|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|negative regulation of NF-kappaB transcription factor activity|nerve growth factor receptor signaling pathway|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|I-kappaB/NF-kappaB complex|nucleus|plasma membrane	identical protein binding|NF-kappaB binding|nuclear localization sequence binding|ubiquitin protein ligase binding			breast(2)	2	Breast(36;0.0484)|Hepatocellular(127;0.158)		Lung(238;9.25e-06)|LUAD - Lung adenocarcinoma(48;1.53e-05)|Epithelial(34;0.00314)|all cancers(34;0.00891)	GBM - Glioblastoma multiforme(112;0.0222)		AACACACAGTCATCATAGGGC	0.453		NaN											0	0	0	0.028581	0	13	126									
LRFN5	145581	broad.mit.edu	37	14	42356424	42356424	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr14:42356424G>A	uc001wvm.2	+	3	1794	c.596G>A	c.(595-597)CGG>CAG	p.R199Q	LRFN5_uc010ana.2_Missense_Mutation_p.R199Q	NM_152447	NP_689660	Q96NI6	LRFN5_HUMAN	leucine rich repeat and fibronectin type III	199	Extracellular (Potential).|LRR 7.					integral to membrane				ovary(5)|pancreas(2)|central_nervous_system(1)	8			LUAD - Lung adenocarcinoma(50;0.0223)|Lung(238;0.0728)	GBM - Glioblastoma multiforme(112;0.00847)		AAGATGACTCGGTTAGATGTG	0.438		NaN								HNSCC(30;0.082)			0	0	0	0.014758	0	4	31									
FAM161B	145483	broad.mit.edu	37	14	74401048	74401048	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr14:74401048C>G	uc001xpd.1	-	9	1961	c.1855G>C	c.(1855-1857)GAA>CAA	p.E619Q		NM_152445	NP_689658			hypothetical protein LOC145483											ovary(1)	1						AGAGATCCTTCTAAACCCTGC	0.373		NaN											0	0	0	0.038147	0	6	100									
ATP10A	57194	broad.mit.edu	37	15	25953415	25953415	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr15:25953415G>C	uc010ayu.2	-	11	2483	c.2377C>G	c.(2377-2379)CGG>GGG	p.R793G		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	793	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity	p.R793W(1)		pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GTTTTGCTCCGAATCTTTTTT	0.537		NaN											0	0	0	0.014758	0	4	121									
NDUFAF1	51103	broad.mit.edu	37	15	41689076	41689076	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr15:41689076C>A	uc001znx.2	-	2	564	c.182G>T	c.(181-183)GGA>GTA	p.G61V	NDUFAF1_uc010bcf.2_RNA	NM_016013	NP_057097	Q9Y375	CIA30_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	61					mitochondrial electron transport, NADH to ubiquinone|protein complex assembly	mitochondrial respiratory chain complex I	unfolded protein binding			ovary(1)	1		all_cancers(109;5.07e-19)|all_epithelial(112;2.43e-16)|Lung NSC(122;1.81e-11)|all_lung(180;4.81e-10)|Melanoma(134;0.0179)|Colorectal(260;0.0946)|Ovarian(310;0.143)		OV - Ovarian serous cystadenocarcinoma(18;8e-17)|GBM - Glioblastoma multiforme(113;1.38e-06)|BRCA - Breast invasive adenocarcinoma(123;0.114)		CTGGTGATCTCCTTGCAAATC	0.423		NaN											1	0	0.000442599	0.058154	0.000484752	7	205									
LCTL	197021	broad.mit.edu	37	15	66853375	66853375	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr15:66853375C>A	uc002aqc.2	-	6	806	c.674G>T	c.(673-675)GGC>GTC	p.G225V	LCTL_uc002aqd.3_Missense_Mutation_p.G52V|LCTL_uc010bhw.2_Intron	NM_207338	NP_997221	Q6UWM7	LCTL_HUMAN	lactase-like precursor	225	Extracellular (Potential).				carbohydrate metabolic process	endoplasmic reticulum membrane|integral to membrane	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(2)	2						CTTGTACAGGCCGGTGCCGCG	0.602		NaN											1	0	0.00198382	0.02938	0.00212222	6	71									
NOX5	79400	broad.mit.edu	37	15	69328242	69328242	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr15:69328242C>G	uc002ars.1	+	7	1174	c.1154C>G	c.(1153-1155)TCC>TGC	p.S385C	NOX5_uc002arp.1_Missense_Mutation_p.S367C|NOX5_uc002arq.1_Missense_Mutation_p.S339C|NOX5_uc010bid.1_Missense_Mutation_p.S350C|NOX5_uc002arr.1_Missense_Mutation_p.S357C|NOX5_uc010bie.1_Missense_Mutation_p.S185C|NOX5_uc010bif.1_RNA	NM_024505	NP_078781	Q96PH1	NOX5_HUMAN	NADPH oxidase, EF-hand calcium binding domain 5	385	Ferric oxidoreductase.|Cytoplasmic (Potential).				angiogenesis|angiogenesis|cytokine secretion|cytokinesis|electron transport chain|endothelial cell proliferation|induction of apoptosis|positive regulation of reactive oxygen species metabolic process|regulation of fusion of sperm to egg plasma membrane|regulation of proton transport|superoxide anion generation	endoplasmic reticulum|endoplasmic reticulum|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|hydrogen ion channel activity|NADP binding|superoxide-generating NADPH oxidase activity			breast(1)|pancreas(1)	2						TTCATCTGCTCCAGTTCCTGC	0.597		NaN											0	0	0	0.02938	0	6	185									
FAM169B	283777	broad.mit.edu	37	15	98995216	98995216	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr15:98995216C>T	uc002buk.1	-	5	458	c.208G>A	c.(208-210)GGT>AGT	p.G70S		NM_182562	NP_872368	Q8N8A8	F169B_HUMAN	hypothetical protein LOC283777	70											0						TAGCATGCACCGGTGCCATCA	0.592		NaN											0	0	0	0.004672	0	3	63									
NEURL4	84461	broad.mit.edu	37	17	7230206	7230206	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr17:7230206C>A	uc002gga.1	-	4	923	c.916G>T	c.(916-918)GCT>TCT	p.A306S	NEURL4_uc002ggb.1_Missense_Mutation_p.A306S|NEURL4_uc002ggc.1_5'UTR	NM_032442	NP_115818	Q96JN8	NEUL4_HUMAN	neuralized homolog 4 isoform 1	306							protein binding			upper_aerodigestive_tract(1)|ovary(1)	2						GAGGTGGCAGCACCGCTAGAT	0.562		NaN											1	0	8.12818e-05	0.02938	9.00955e-05	5	91									
TP53	7157	broad.mit.edu	37	17	7578419	7578419	+	Nonsense_Mutation	SNP	C	C	A			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08			C	A	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr17:7578419C>A	uc002gim.2	-	5	705	c.511G>T	c.(511-513)GAG>TAG	p.E171*	TP53_uc002gig.1_Nonsense_Mutation_p.E171*|TP53_uc002gih.2_Nonsense_Mutation_p.E171*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.E39*|TP53_uc010cng.1_Nonsense_Mutation_p.E39*|TP53_uc002gii.1_Nonsense_Mutation_p.E39*|TP53_uc010cnh.1_Nonsense_Mutation_p.E171*|TP53_uc010cni.1_Nonsense_Mutation_p.E171*|TP53_uc002gij.2_Nonsense_Mutation_p.E171*|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Nonsense_Mutation_p.E78*|TP53_uc002gio.2_Nonsense_Mutation_p.E39*|TP53_uc010vug.1_Nonsense_Mutation_p.E132*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	171	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> G (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> A (in a sporadic cancer; somatic mutation).|E -> Q (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E171*(10)|p.E171K(8)|p.0?(7)|p.E171G(3)|p.E171Q(3)|p.E171fs*10(3)|p.E171fs*3(2)|p.E171V(2)|p.E171D(2)|p.V157_C176del20(1)|p.K164_P219del(1)|p.P151_V173del23(1)|p.E171fs*61(1)|p.E171fs*9(1)|p.T170fs*2(1)|p.E171fs*1(1)|p.T170fs*8(1)|p.E171_V172delEV(1)|p.H168fs*69(1)|p.T170_E171insXX(1)|p.E171_H179delEVVRRCPHH(1)|p.S149fs*72(1)|p.E171A(1)|p.H168fs*3(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CTCACAACCTCCGTCATGTGC	0.662		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			1	0	5.9392e-07	0.021553	6.74576e-07	5	75									
C17orf48	56985	broad.mit.edu	37	17	10608569	10608569	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr17:10608569G>A	uc002gmt.2	+	2	401	c.326G>A	c.(325-327)GGA>GAA	p.G109E	C17orf48_uc002gmu.2_RNA|C17orf48_uc002gmv.2_RNA|C17orf48_uc010vvg.1_Missense_Mutation_p.G109E	NM_020233	NP_064618	Q3LIE5	ADPRM_HUMAN	ADP-ribose/CDP-alcohol pyrophosphatase	109							ADP-ribose diphosphatase activity|CDP-glycerol diphosphatase activity|metal ion binding				0						CATACATGGGGAAACCATGAA	0.358		NaN											0	0	0	0.02938	0	5	77									
ITGA2B	3674	broad.mit.edu	37	17	42458417	42458417	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr17:42458417G>A	uc002igt.1	-	13	1255	c.1223C>T	c.(1222-1224)GCT>GTT	p.A408V	ITGA2B_uc002igu.1_5'UTR	NM_000419	NP_000410	P08514	ITA2B_HUMAN	integrin alpha 2b preproprotein	408	Extracellular (Potential).|FG-GAP 6.				axon guidance|integrin-mediated signaling pathway|platelet activation|platelet degranulation	integrin complex|platelet alpha granule membrane	identical protein binding|receptor activity			ovary(2)|lung(1)	3		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.191)	Tirofiban(DB00775)	GTAGGGGGCAGCCACTGCAAT	0.577		NaN											0	0	0	0.014758	0	3	43									
TBX4	9496	broad.mit.edu	37	17	59560439	59560439	+	Silent	SNP	G	G	A			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr17:59560439G>A	uc002izi.2	+	8	1245	c.1200G>A	c.(1198-1200)GAG>GAA	p.E400E	TBX4_uc010ddo.2_Silent_p.E401E|TBX4_uc010woy.1_Silent_p.E401E	NM_018488	NP_060958	P57082	TBX4_HUMAN	T-box 4	400					leg morphogenesis|skeletal system morphogenesis	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			skin(2)	2						CAGGGCCCGAGATTGCCGGGG	0.607		NaN											0	0	0	0.047766	0	8	90									
CAPN12	147968	broad.mit.edu	37	19	39226178	39226178	+	Silent	SNP	G	G	T			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr19:39226178G>T	uc002ojd.1	-	13	1899	c.1590C>A	c.(1588-1590)ATC>ATA	p.I530I	CAPN12_uc010egd.1_5'Flank|CAPN12_uc002ojc.1_5'UTR	NM_144691	NP_653292	Q6ZSI9	CAN12_HUMAN	calpain 12	530	Domain III.				proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			central_nervous_system(1)|pancreas(1)	2	all_cancers(60;2.87e-05)|Ovarian(47;0.0454)		Lung(45;0.00416)|LUSC - Lung squamous cell carcinoma(53;0.00741)			TCACGTCGTCGATCTCCCTGC	0.632		NaN											1	0	1.23904e-05	0.014758	1.39014e-05	5	34									
TPRX1	284355	broad.mit.edu	37	19	48305091	48305091	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr19:48305091C>G	uc002php.1	-	2	1248	c.1177G>C	c.(1177-1179)GAG>CAG	p.E393Q		NM_198479	NP_940881	Q8N7U7	TPRX1_HUMAN	tetra-peptide repeat homeobox	393						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(25;3.02e-09)|all_epithelial(76;7e-07)|all_lung(116;2.48e-06)|Lung NSC(112;5.15e-06)|Ovarian(192;0.0139)|all_neural(266;0.0146)|Breast(70;0.133)		OV - Ovarian serous cystadenocarcinoma(262;0.000241)|all cancers(93;0.00036)|Epithelial(262;0.0127)|GBM - Glioblastoma multiforme(486;0.048)		CCACCCTCCTCTTGGGGCTGA	0.532		NaN											0	0	0	0.021553	0	6	173									
NEB	4703	broad.mit.edu	37	2	152543972	152543972	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr2:152543972C>G	uc010fnx.2	-	27	2789	c.2598G>C	c.(2596-2598)AAG>AAC	p.K866N		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	866	Nebulin 20.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		AGTGCAGCATCTTTGGATCGT	0.438		NaN											0	0	0	0.047766	0	8	178									
TTN	7273	broad.mit.edu	37	2	179474565	179474565	+	Silent	SNP	C	C	T			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr2:179474565C>T	uc010zfg.1	-	221	44105	c.43881G>A	c.(43879-43881)AAG>AAA	p.K14627K	uc002ump.1_Intron|TTN_uc010zfh.1_Silent_p.K8322K|TTN_uc010zfi.1_Silent_p.K8255K|TTN_uc010zfj.1_Silent_p.K8130K	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15554							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CATTGCATCTCTTCCACCTTT	0.473		NaN											0	0	0	0.020292	0	12	564									
C20orf70	140683	broad.mit.edu	37	20	31757018	31757018	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr20:31757018G>C	uc002wyo.1	+	2	138	c.67G>C	c.(67-69)GAC>CAC	p.D23H		NM_080574	NP_542141	Q96DR5	SPLC2_HUMAN	chromosome 20 open reading frame 70 precursor	23						extracellular region	lipid binding			ovary(1)|central_nervous_system(1)	2						GTCTCTTCTTGACAATCTTGG	0.463		NaN											0	0	0	0.009096	0	4	186									
CECR2	27443	broad.mit.edu	37	22	17976598	17976598	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr22:17976598G>A	uc010gqw.1	+	2	385	c.259G>A	c.(259-261)GAT>AAT	p.D87N	CECR2_uc010gqv.1_5'UTR|CECR2_uc002zml.2_5'UTR|CECR2_uc002zmm.1_5'Flank	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	129					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)		GGATGCAGACGATGTCTTCGA	0.512		NaN											0	0	0	0.014758	0	4	125									
EP300	2033	broad.mit.edu	37	22	41545867	41545867	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr22:41545867C>T	uc003azl.3	+	14	2877	c.2482C>T	c.(2482-2484)CAT>TAT	p.H828Y		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	828					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						ACCAGCTCTTCATCAGAATTC	0.552		NaN	T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.021553	0	4	58									
EP300	2033	broad.mit.edu	37	22	41545870	41545870	+	Nonsense_Mutation	SNP	C	C	T			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr22:41545870C>T	uc003azl.3	+	14	2880	c.2485C>T	c.(2485-2487)CAG>TAG	p.Q829*		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	829					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						AGCTCTTCATCAGAATTCACC	0.562		NaN	T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.021553	0	4	59									
GRM2	2912	broad.mit.edu	37	3	51749893	51749893	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr3:51749893G>A	uc010hlv.2	+	4	2343	c.2104G>A	c.(2104-2106)GCA>ACA	p.A702T	GRM2_uc003dbo.3_Missense_Mutation_p.A84T|GRM2_uc010hlu.2_RNA	NM_000839	NP_000830	Q14416	GRM2_HUMAN	glutamate receptor, metabotropic 2 isoform a	702	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Acamprosate(DB00659)|Nicotine(DB00184)	GGTGGTGGAGGCACCGGGCAC	0.652		NaN											0	0	0	0.009096	0	3	44									
NAALADL2	254827	broad.mit.edu	37	3	175293969	175293969	+	Silent	SNP	A	A	G			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr3:175293969A>G	uc003fit.2	+	10	1881	c.1794A>G	c.(1792-1794)ACA>ACG	p.T598T	NAALADL2_uc003fiu.1_Silent_p.T591T|NAALADL2_uc010hwy.1_Silent_p.T372T	NM_207015	NP_996898	Q58DX5	NADL2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	598	Extracellular (Potential).				proteolysis	integral to membrane	peptidase activity			pancreas(1)	1	Ovarian(172;0.0102)	all_cancers(1;0.0272)|all_epithelial(1;0.0553)	OV - Ovarian serous cystadenocarcinoma(80;9.26e-28)	Colorectal(1;1.66e-10)|COAD - Colon adenocarcinoma(1;2.1e-07)|STAD - Stomach adenocarcinoma(1;0.00261)|READ - Rectum adenocarcinoma(3;0.0284)		ACATCAAAACATTAGAGGTGA	0.348		NaN											0	0	0	0.014758	0	5	175									
TP63	8626	broad.mit.edu	37	3	189455608	189455608	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr3:189455608G>A	uc003fry.2	+	2	231	c.142G>A	c.(142-144)GAA>AAA	p.E48K	TP63_uc003frx.2_Missense_Mutation_p.E48K|TP63_uc003frz.2_Missense_Mutation_p.E48K|TP63_uc010hzc.1_Missense_Mutation_p.E48K	NM_003722	NP_003713	Q9H3D4	P63_HUMAN	tumor protein p63 isoform 1	48	Transcription activation.				anti-apoptosis|cellular response to UV|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of transcription from RNA polymerase II promoter|Notch signaling pathway|positive regulation of Notch signaling pathway|protein homotetramerization|regulation of neuron apoptosis|response to gamma radiation|response to X-ray	chromatin|cytosol|dendrite|Golgi apparatus|transcription factor complex	chromatin binding|damaged DNA binding|double-stranded DNA binding|identical protein binding|metal ion binding|p53 binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(5)|lung(4)|ovary(2)|upper_aerodigestive_tract(1)	12	all_cancers(143;3.35e-10)|Ovarian(172;0.0925)		Lung(62;3.33e-05)	GBM - Glioblastoma multiforme(93;0.0227)		ACAGACAAATGAATTCCTCAG	0.378		NaN							Hay-Wells_syndrome	HNSCC(45;0.13)			0	0	0	0.009096	0	4	102									
MFI2	4241	broad.mit.edu	37	3	196730882	196730882	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr3:196730882G>A	uc003fxk.3	-	15	2140	c.2027C>T	c.(2026-2028)GCC>GTC	p.A676V	uc003fxi.2_5'Flank|uc003fxj.1_Intron	NM_005929	NP_005920	P08582	TRFM_HUMAN	melanoma-associated antigen p97 isoform 1	676	Transferrin-like 2.				cellular iron ion homeostasis|iron ion transport	anchored to membrane|extracellular region|integral to plasma membrane	ferric iron binding|protein binding				0	all_cancers(143;3.95e-09)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.55e-24)|all cancers(36;2.87e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00536)		CCGGACGGTGGCATCCTTGAA	0.587		NaN											0	0	0	0.049695	0	16	596									
OCIAD2	132299	broad.mit.edu	37	4	48894829	48894829	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr4:48894829C>G	uc003gyt.2	-	6	546	c.343G>C	c.(343-345)GAT>CAT	p.D115H	OCIAD2_uc003gyu.2_Intron	NM_001014446	NP_001014446	Q56VL3	OCAD2_HUMAN	OCIA domain containing 2 isoform 1	115	OCIA.					endosome					0						CGGAGCTGATCTTCAAAAAAA	0.393		NaN											0	0	0	0.047766	0	7	330									
SPRY1	10252	broad.mit.edu	37	4	124322883	124322883	+	Missense_Mutation	SNP	C	C	A			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr4:124322883C>A	uc003ifa.2	+	2	325	c.137C>A	c.(136-138)GCC>GAC	p.A46D	SPRY1_uc003ifb.2_Missense_Mutation_p.A46D	NM_199327	NP_955359	O43609	SPY1_HUMAN	sprouty homolog 1, antagonist of FGF signaling	46					epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|lamellipodium|plasma membrane				skin(2)|ovary(1)	3						CAGATCAAGGCCATAAGAGGC	0.463		NaN											1	0	0.000602214	0.014758	0.000651809	5	182									
FAT4	79633	broad.mit.edu	37	4	126412493	126412493	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr4:126412493C>G	uc003ifj.3	+	17	14516	c.14516C>G	c.(14515-14517)TCT>TGT	p.S4839C	FAT4_uc011cgp.1_Missense_Mutation_p.S3080C|FAT4_uc003ifi.1_Missense_Mutation_p.S2316C	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	FAT tumor suppressor homolog 4 precursor	4839	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(9)|skin(5)|upper_aerodigestive_tract(2)|pancreas(2)	18						CCAGAATCCTCTTCTGATAGT	0.468		NaN											0	0	0	0.009096	0	4	86									
DNAH5	1767	broad.mit.edu	37	5	13729630	13729630	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr5:13729630G>A	uc003jfd.2	-	69	11843	c.11801C>T	c.(11800-11802)CCA>CTA	p.P3934L	DNAH5_uc003jfc.2_Missense_Mutation_p.P102L	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3934					microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CCATTTTGATGGTTTTGGAGG	0.358		NaN							Kartagener_syndrome				0	0	0	0.009096	0	4	117									
DNAH5	1767	broad.mit.edu	37	5	13844961	13844961	+	Silent	SNP	G	G	C			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr5:13844961G>C	uc003jfd.2	-	32	5298	c.5256C>G	c.(5254-5256)GTC>GTG	p.V1752V		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	1752	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					CGTGGAACTTGACAGATTTAA	0.468		NaN							Kartagener_syndrome				0	0	0	0.02938	0	6	237									
ADAMTS12	81792	broad.mit.edu	37	5	33588860	33588860	+	Silent	SNP	C	C	T			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr5:33588860C>T	uc003jia.1	-	18	2872	c.2709G>A	c.(2707-2709)GAG>GAA	p.E903E	ADAMTS12_uc010iuq.1_Silent_p.E818E	NM_030955	NP_112217	P58397	ATS12_HUMAN	ADAM metallopeptidase with thrombospondin type 1	903	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)	9						TTCGCTTCTTCTCCCCGTGGG	0.607		NaN								HNSCC(64;0.19)	OREG0016553	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.049695	0	16	84									
MSH3	4437	broad.mit.edu	37	5	79974807	79974807	+	Nonsense_Mutation	SNP	C	C	G			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr5:79974807C>G	uc003kgz.2	+	8	1488	c.1235C>G	c.(1234-1236)TCA>TGA	p.S412*		NM_002439	NP_002430	P20585	MSH3_HUMAN	mutS homolog 3	412					maintenance of DNA repeat elements|meiotic mismatch repair|negative regulation of DNA recombination|positive regulation of helicase activity|reciprocal meiotic recombination|somatic recombination of immunoglobulin gene segments	MutSbeta complex|nuclear chromosome	ATP binding|DNA-dependent ATPase activity|double-strand/single-strand DNA junction binding|enzyme binding|loop DNA binding|Y-form DNA binding			lung(2)|ovary(1)|breast(1)	4		Lung NSC(167;0.00479)|all_lung(232;0.00507)|Ovarian(174;0.0261)|Breast(144;0.244)		OV - Ovarian serous cystadenocarcinoma(54;2.38e-45)|Epithelial(54;1.58e-38)|all cancers(79;4.93e-33)		GCTTCTCGTTCAGAGCTAGAA	0.488		NaN						MMR					0	0	0	0.02938	0	6	224									
LNPEP	4012	broad.mit.edu	37	5	96341855	96341855	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr5:96341855C>G	uc003kmv.1	+	10	2378	c.1864C>G	c.(1864-1866)CAA>GAA	p.Q622E	LNPEP_uc003kmw.1_Missense_Mutation_p.Q608E	NM_005575	NP_005566	Q9UIQ6	LCAP_HUMAN	leucyl/cystinyl aminopeptidase isoform 1	622	Extracellular (Potential).				cell-cell signaling|female pregnancy|proteolysis	extracellular region|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|zinc ion binding			ovary(3)|breast(1)	4		all_cancers(142;7e-07)|all_epithelial(76;9.52e-10)|all_lung(232;0.00101)|Lung NSC(167;0.00137)|Ovarian(225;0.024)|Colorectal(57;0.0269)|Breast(839;0.244)		COAD - Colon adenocarcinoma(37;0.072)		AGTGACTGTTCAAAAGAAAGG	0.333		NaN											0	0	0	0.009096	0	3	69									
PCDHA1	56147	broad.mit.edu	37	5	140167577	140167577	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr5:140167577C>T	uc003lhb.2	+	1	1702	c.1702C>T	c.(1702-1704)CCT>TCT	p.P568S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lgz.2_Missense_Mutation_p.P568S	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	568	Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCTGCTGGCGCCTCGAGTGGG	0.687		NaN											0	0	0	0.021553	0	6	107									
PCDHGA7	56108	broad.mit.edu	37	5	140762743	140762743	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr5:140762743G>A	uc003lka.1	+	1	277	c.277G>A	c.(277-279)GAA>AAA	p.E93K	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003ljz.1_Missense_Mutation_p.E93K	NM_018920	NP_061743	Q9Y5G6	PCDG7_HUMAN	protocadherin gamma subfamily A, 7 isoform 1	93	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATAGACCGGGAAGAGATCTG	0.527		NaN											0	0	0	0.009096	0	4	93									
GNB2L1	10399	broad.mit.edu	37	5	180668594	180668594	+	Silent	SNP	C	C	G			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr5:180668594C>G	uc003mni.1	-	3	433	c.327G>C	c.(325-327)CTG>CTC	p.L109L	GNB2L1_uc003mnh.1_Silent_p.L68L|GNB2L1_uc003mnk.1_Silent_p.L31L|GNB2L1_uc003mnj.1_Silent_p.L63L|GNB2L1_uc003mnl.1_5'UTR|GNB2L1_uc011dhk.1_Silent_p.L109L|GNB2L1_uc010jls.2_Silent_p.L68L|GNB2L1_uc011dhl.1_Silent_p.L109L	NM_006098	NP_006089	P63244	GBLP_HUMAN	guanine nucleotide binding protein (G protein),	109	WD 3.			Missing (in Ref. 4; BAG53102).	apoptosis|cell cycle|gastrulation|interspecies interaction between organisms|negative regulation of cell growth|negative regulation of phagocytosis|negative regulation of translation|negative regulation of Wnt receptor signaling pathway|positive regulation of apoptosis|positive regulation of cell migration|positive regulation of gastrulation|positive regulation of GTPase activity|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein homooligomerization|positive regulation of protein phosphorylation|regulation of cell cycle|regulation of cell division|regulation of establishment of cell polarity|regulation of protein localization|rhythmic process	cytoskeleton|dendrite|midbody|nucleus|perikaryon|perinuclear region of cytoplasm|phagocytic cup|small ribosomal subunit	ion channel inhibitor activity|protein kinase C binding|protein phosphatase binding|protein tyrosine kinase inhibitor activity|receptor tyrosine kinase binding|SH2 domain binding				0	all_cancers(89;8.79e-06)|all_epithelial(37;1.13e-06)|Renal(175;0.000159)|Lung NSC(126;0.00354)|all_lung(126;0.00609)|Breast(19;0.0654)	all_cancers(40;0.000209)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_lung(500;0.0221)|all_hematologic(541;0.0433)|Lung NSC(249;0.132)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.101)|all cancers(165;0.11)		AGGCCACACTCAGCACATCCT	0.507		NaN											0	0	0	0.021553	0	5	98									
TNXB	7148	broad.mit.edu	37	6	32015700	32015700	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr6:32015700C>T	uc003nzl.2	-	30	10331	c.10129G>A	c.(10129-10131)GAG>AAG	p.E3377K	TNXB_uc003nzg.1_5'Flank|TNXB_uc003nzh.1_5'Flank	NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	3424	Fibronectin type-III 26.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						AATTCGCCCTCAGGGACCGTC	0.637		NaN											0	0	0	0.009096	0	4	59									
FANCE	2178	broad.mit.edu	37	6	35426085	35426085	+	Silent	SNP	G	G	T			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr6:35426085G>T	uc003oko.1	+	5	1166	c.981G>T	c.(979-981)CTG>CTT	p.L327L	FANCE_uc010jvw.1_Intron	NM_021922	NP_068741	Q9HB96	FANCE_HUMAN	Fanconi anemia, complementation group E	327	Interaction with FANCC.				DNA repair	nucleoplasm	protein binding			ovary(1)|lung(1)|skin(1)	3						TGGACTTGCTGTGTGCCCAGC	0.602		NaN	N|F|S			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				1	0	1.5842e-08	0.105934	1.84489e-08	13	186									
DNAH8	1769	broad.mit.edu	37	6	38834595	38834595	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr6:38834595C>G	uc003ooe.1	+	45	6585	c.5985C>G	c.(5983-5985)ATC>ATG	p.I1995M		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						AAAATGTTATCTTGGCTCAAA	0.303		NaN											0	0	0	0.02938	0	5	47									
PURB	5814	broad.mit.edu	37	7	44924329	44924329	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr7:44924329C>T	uc003tme.2	-	1	632	c.619G>A	c.(619-621)GGC>AGC	p.G207S		NM_033224	NP_150093	Q96QR8	PURB_HUMAN	purine-rich element binding protein B	207	Gly-rich.|By similarity.				regulation of myeloid cell differentiation	DNA replication factor A complex	mRNA binding|single-stranded DNA binding|transcription factor binding				0						cccccggcgccgcctcccggg	0.502		NaN											0	0	0	0.004672	0	3	38									
FZD9	8326	broad.mit.edu	37	7	72849103	72849103	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr7:72849103G>C	uc003tyb.2	+	1	995	c.766G>C	c.(766-768)GAG>CAG	p.E256Q		NM_003508	NP_003499	O00144	FZD9_HUMAN	frizzled 9 precursor	256	Cytoplasmic (Potential).				B cell differentiation|brain development|canonical Wnt receptor signaling pathway|embryo development|gonad development|neuroblast proliferation|vasculature development	cell surface|filopodium membrane|integral to membrane|perinuclear region of cytoplasm	G-protein coupled receptor activity|PDZ domain binding|protein heterodimerization activity|protein homodimerization activity|Wnt receptor activity|Wnt-protein binding			central_nervous_system(1)	1		Lung NSC(55;0.0659)|all_lung(88;0.152)				CTTCTTGCTGGAGCCCCACCG	0.642		NaN											0	0	0	0.021553	0	5	188									
CYP3A4	1576	broad.mit.edu	37	7	99366067	99366067	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr7:99366067C>T	uc003urv.1	-	7	684	c.580G>A	c.(580-582)GAC>AAC	p.D194N	CYP3A4_uc003urw.1_Missense_Mutation_p.D194N|CYP3A4_uc011kiz.1_Missense_Mutation_p.D153N|CYP3A4_uc011kja.1_Missense_Mutation_p.D145N|CYP3A4_uc011kjb.1_Missense_Mutation_p.D44N	NM_017460	NP_059488	P08684	CP3A4_HUMAN	cytochrome P450, family 3, subfamily A,	194					alkaloid catabolic process|androgen metabolic process|exogenous drug catabolic process|heterocycle metabolic process|monoterpenoid metabolic process|oxidative demethylation|steroid catabolic process|xenobiotic metabolic process	cell surface|endoplasmic reticulum membrane|integral to membrane|microsome	albendazole monooxygenase activity|caffeine oxidase activity|electron carrier activity|enzyme binding|heme binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen|oxygen binding|quinine 3-monooxygenase activity|steroid binding|taurochenodeoxycholate 6alpha-hydroxylase activity|testosterone 6-beta-hydroxylase activity|vitamin D 24-hydroxylase activity|vitamin D3 25-hydroxylase activity			central_nervous_system(3)|ovary(1)	4	Lung NSC(181;0.0144)|Esophageal squamous(72;0.0166)|all_lung(186;0.0228)				Albendazole(DB00518)|Alclometasone(DB00240)|Alfentanil(DB00802)|Alfuzosin(DB00346)|Aliskiren(DB01258)|Almotriptan(DB00918)|Alosetron(DB00969)|Alprazolam(DB00404)|Amlodipine(DB00381)|Amprenavir(DB00701)|Aprepitant(DB00673)|Aripiprazole(DB01238)|Astemizole(DB00637)|Atazanavir(DB01072)|Atorvastatin(DB01076)|Benazepril(DB00542)|Bepridil(DB01244)|Betamethasone(DB00443)|Bexarotene(DB00307)|Bortezomib(DB00188)|Bosentan(DB00559)|Bromocriptine(DB01200)|Budesonide(DB01222)|Bupivacaine(DB00297)|Buprenorphine(DB00921)|Buspirone(DB00490)|Busulfan(DB01008)|Carbamazepine(DB00564)|Cevimeline(DB00185)|Chlorpheniramine(DB01114)|Ciclesonide(DB01410)|Cilostazol(DB01166)|Cinacalcet(DB01012)|Cisapride(DB00604)|Clarithromycin(DB01211)|Clindamycin(DB01190)|Clofibrate(DB00636)|Clonazepam(DB01068)|Clopidogrel(DB00758)|Cocaine(DB00907)|Conivaptan(DB00872)|Conjugated Estrogens(DB00286)|Cyproterone(DB04839)|Darifenacin(DB00496)|Darunavir(DB01264)|Dasatinib(DB01254)|Delavirdine(DB00705)|Desogestrel(DB00304)|Dexamethasone(DB01234)|Diazepam(DB00829)|Dihydroergotamine(DB00320)|Diltiazem(DB00343)|Diphenhydramine(DB01075)|Disopyramide(DB00280)|Dofetilide(DB00204)|Dolasetron(DB00757)|Domperidone(DB01184)|Donepezil(DB00843)|Doxorubicin(DB00997)|Drospirenone(DB01395)|Dutasteride(DB01126)|Efavirenz(DB00625)|Eletriptan(DB00216)|Enalapril(DB00584)|Epirubicin(DB00445)|Eplerenone(DB00700)|Ergotamine(DB00696)|Erlotinib(DB00530)|Erythromycin(DB00199)|Escitalopram(DB01175)|Esomeprazole(DB00736)|Estazolam(DB01215)|Eszopiclone(DB00402)|Ethinyl Estradiol(DB00977)|Ethosuximide(DB00593)|Etonogestrel(DB00294)|Etoposide(DB00773)|Etoricoxib(DB01628)|Exemestane(DB00990)|Felodipine(DB01023)|Fentanyl(DB00813)|Fexofenadine(DB00950)|Finasteride(DB01216)|Fluconazole(DB00196)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Fosamprenavir(DB01319)|Fulvestrant(DB00947)|Galantamine(DB00674)|Gefitinib(DB00317)|Gemfibrozil(DB01241)|Granisetron(DB00889)|Grepafloxacin(DB00365)|Halofantrine(DB01218)|Hydrocodone(DB00956)|Hydrocortamate(DB00769)|Hydrocortisone(DB00741)|Hydromorphone(DB00327)|Imatinib(DB00619)|Indinavir(DB00224)|Ipratropium(DB00332)|Irinotecan(DB00762)|Isosorbide Dinitrate(DB00883)|Isosorbide Mononitrate(DB01020)|Isradipine(DB00270)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lercanidipine(DB00528)|Letrozole(DB01006)|Levobupivacaine(DB01002)|Levomethadyl Acetate(DB01227)|Levothyroxine(DB00451)|Lomustine(DB01206)|Loperamide(DB00836)|Lopinavir(DB01601)|Loratadine(DB00455)|Losartan(DB00678)|Lovastatin(DB00227)|Maraviroc(DB04835)|Marinol(DB00470)|Mebendazole(DB00643)|Medroxyprogesterone(DB00603)|Methadone(DB00333)|Methylprednisolone(DB00959)|Metyrapone(DB01011)|Mibefradil(DB01388)|Midazolam(DB00683)|Mifepristone(DB00834)|Mirtazapine(DB00370)|Modafinil(DB00745)|Mometasone(DB00764)|Montelukast(DB00471)|Nateglinide(DB00731)|Nefazodone(DB01149)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicardipine(DB00622)|Nifedipine(DB01115)|Nimodipine(DB00393)|Nisoldipine(DB00401)|Nitrendipine(DB01054)|Norethindrone(DB00717)|Norgestrel(DB00506)|Nystatin(DB00646)|Ondansetron(DB00904)|Oxybutynin(DB01062)|Paclitaxel(DB01229)|Paliperidone(DB01267)|Palonosetron(DB00377)|Pantoprazole(DB00213)|Paricalcitol(DB00910)|Phenmetrazine(DB00830)|Pimecrolimus(DB00337)|Pimozide(DB01100)|Pioglitazone(DB01132)|Posaconazole(DB01263)|Pranlukast(DB01411)|Prednisolone(DB00860)|Prednisone(DB00635)|Prochlorperazine(DB00433)|Quetiapine(DB01224)|Quinapril(DB00881)|Quinine(DB00468)|Rabeprazole(DB01129)|Ranolazine(DB00243)|Reboxetine(DB00234)|Retapamulin(DB01256)|Rifabutin(DB00615)|Rifampin(DB01045)|Rimonabant(DB06155)|Ritonavir(DB00503)|Rofecoxib(DB00533)|Roxithromycin(DB00778)|Salmeterol(DB00938)|Saquinavir(DB01232)|Sertindole(DB06144)|Sibutramine(DB01105)|Simvastatin(DB00641)|Sirolimus(DB00877)|Sitagliptin(DB01261)|Solifenacin(DB01591)|Sorafenib(DB00398)|Sunitinib(DB01268)|Tacrolimus(DB00864)|Tadalafil(DB00820)|Tamoxifen(DB00675)|Telithromycin(DB00976)|Terconazole(DB00251)|Terfenadine(DB00342)|Testosterone(DB00624)|Tiagabine(DB00906)|Ticlopidine(DB00208)|Tinidazole(DB00911)|Tiotropium(DB01409)|Tipranavir(DB00932)|Toremifene(DB00539)|Triazolam(DB00897)|Trimetrexate(DB01157)|Troglitazone(DB00197)|Valdecoxib(DB00580)|Vardenafil(DB00862)|Vinblastine(DB00570)|Vincristine(DB00541)|Vindesine(DB00309)|Vinorelbine(DB00361)|Voriconazole(DB00582)|Zaleplon(DB00962)|Zileuton(DB00744)|Ziprasidone(DB00246)|Zolpidem(DB00425)|Zonisamide(DB00909)	TTGAGAGAGTCGATGTTCACT	0.403		NaN											0	0	0	0.014758	0	5	144									
C7orf58	79974	broad.mit.edu	37	7	120740099	120740099	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr7:120740099C>T	uc003vjq.3	+	7	1316	c.869C>T	c.(868-870)TCG>TTG	p.S290L	C7orf58_uc003vjr.1_Missense_Mutation_p.S290L|C7orf58_uc003vjs.3_Missense_Mutation_p.S290L|C7orf58_uc003vjt.3_Missense_Mutation_p.S70L|C7orf58_uc010lkk.1_Missense_Mutation_p.S70L	NM_024913	NP_079189	A4D0V7	CG058_HUMAN	hypothetical protein LOC79974 isoform 1	290						endoplasmic reticulum				ovary(4)|large_intestine(2)|skin(2)|pancreas(1)	9	all_neural(327;0.117)					TTCATTCATTCGACGGGCACA	0.428		NaN											0	0	0	0.047766	0	7	64									
CADPS2	93664	broad.mit.edu	37	7	122033257	122033257	+	Missense_Mutation	SNP	C	C	G			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr7:122033257C>G	uc010lkp.2	-	21	3164	c.3001G>C	c.(3001-3003)GAG>CAG	p.E1001Q	CADPS2_uc011knx.1_Missense_Mutation_p.E376Q|CADPS2_uc003vkg.3_Intron|CADPS2_uc010lkq.2_Intron	NM_017954	NP_060424	Q86UW7	CAPS2_HUMAN	Ca2+-dependent activator protein for secretion 2	1001	Interaction with DRD2.|MHD1.				exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|synapse	lipid binding|metal ion binding			ovary(1)|central_nervous_system(1)	2						CACGTGGACTCATATAAAGAA	0.458		NaN											0	0	0	0.004672	0	3	36									
CPA4	51200	broad.mit.edu	37	7	129945685	129945685	+	Silent	SNP	G	G	A			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr7:129945685G>A	uc003vpr.2	+	6	563	c.516G>A	c.(514-516)CCG>CCA	p.P172P	CPA4_uc011kpd.1_Silent_p.P139P|CPA4_uc011kpe.1_Silent_p.P68P	NM_016352	NP_057436	Q9UI42	CBPA4_HUMAN	carboxypeptidase A4 preproprotein	172					histone acetylation|proteolysis	extracellular region	metallocarboxypeptidase activity|zinc ion binding			ovary(1)	1	Melanoma(18;0.0435)					TGAGGCGGCCGGCCGTTTGGC	0.587		NaN											0	0	0	0.038147	0	6	140									
KRBA1	84626	broad.mit.edu	37	7	149425660	149425660	+	Silent	SNP	C	C	G			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr7:149425660C>G	uc003wfz.2	+	12	1920	c.1521C>G	c.(1519-1521)CTC>CTG	p.L507L	KRBA1_uc010lpj.2_RNA|KRBA1_uc003wga.2_RNA|KRBA1_uc003wgb.2_Silent_p.L175L	NM_032534	NP_115923	A5PL33	KRBA1_HUMAN	KRAB A domain containing 1	507										ovary(1)|central_nervous_system(1)	2	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			AGAATTGTCTCAAGGAGATAC	0.577		NaN											0	0	0	0.047766	0	7	221									
ASAH1	427	broad.mit.edu	37	8	17918895	17918895	+	Missense_Mutation	SNP	T	T	C			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr8:17918895T>C	uc003wyl.2	-	10	1088	c.776A>G	c.(775-777)AAT>AGT	p.N259S	ASAH1_uc010ltb.1_RNA|ASAH1_uc003wym.2_Missense_Mutation_p.N234S|ASAH1_uc003wyn.2_Missense_Mutation_p.N275S|ASAH1_uc003wyo.2_Missense_Mutation_p.N253S	NM_177924	NP_808592	Q13510	ASAH1_HUMAN	N-acylsphingosine amidohydrolase 1 isoform a	259					ceramide metabolic process	lysosome	ceramidase activity				0				Colorectal(111;0.0646)|COAD - Colon adenocarcinoma(73;0.228)		CCTTGTGCTATTTTCCAGAAC	0.313		NaN											0	0	0	0.014758	0	4	133									
ANK1	286	broad.mit.edu	37	8	41573364	41573364	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr8:41573364C>T	uc003xok.2	-	14	1492	c.1408G>A	c.(1408-1410)GAC>AAC	p.D470N	NKX6-3_uc010lxa.1_Intron|ANK1_uc003xoi.2_Missense_Mutation_p.D470N|ANK1_uc003xoj.2_Missense_Mutation_p.D470N|ANK1_uc003xol.2_Missense_Mutation_p.D470N|ANK1_uc003xom.2_Missense_Mutation_p.D503N	NM_020476	NP_065209	P16157	ANK1_HUMAN	ankyrin 1 isoform 1	470	ANK 14.|89 kDa domain.				axon guidance|cytoskeleton organization|exocytosis|maintenance of epithelial cell apical/basal polarity|signal transduction	basolateral plasma membrane|cytosol|sarcomere|sarcoplasmic reticulum|spectrin-associated cytoskeleton	cytoskeletal adaptor activity|enzyme binding|protein binding|spectrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(3)|lung(2)|breast(1)	9	Ovarian(28;0.00541)|Colorectal(14;0.0398)|Lung SC(25;0.211)	all_lung(54;0.000626)|Lung NSC(58;0.00245)|Esophageal squamous(32;0.0559)|Hepatocellular(245;0.0663)|Renal(179;0.188)	OV - Ovarian serous cystadenocarcinoma(14;0.000984)|Lung(22;0.00108)|Colorectal(10;0.00245)|LUSC - Lung squamous cell carcinoma(45;0.00392)|COAD - Colon adenocarcinoma(11;0.0264)			GGGGTCTGGTCATCCTGGACC	0.373		NaN											0	0	0	0.021553	0	4	50									
KCNB2	9312	broad.mit.edu	37	8	73849986	73849986	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr8:73849986G>C	uc003xzb.2	+	3	2984	c.2396G>C	c.(2395-2397)AGA>ACA	p.R799T		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	799	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			TTCTCTTCAAGAGAGAGGAGG	0.542		NaN											0	0	0	0.014758	0	3	37									
NAA35	60560	broad.mit.edu	37	9	88557196	88557196	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr9:88557196G>A	uc004aoi.3	+	2	259	c.122G>A	c.(121-123)CGA>CAA	p.R41Q	NAA35_uc004aoj.3_Missense_Mutation_p.R41Q|NAA35_uc004aok.1_Missense_Mutation_p.R41Q	NM_024635	NP_078911	Q5VZE5	NAA35_HUMAN	corneal wound healing-related protein	41					smooth muscle cell proliferation	cytoplasm|nucleus|plasma membrane				skin(2)|central_nervous_system(1)	3						GAAGCTTGTCGAGGTGAGTCT	0.403		NaN											0	0	0	0.069234	0	7	176									
OR13F1	138805	broad.mit.edu	37	9	107267011	107267011	+	Silent	SNP	C	C	G			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr9:107267011C>G	uc011lvm.1	+	1	468	c.468C>G	c.(466-468)GCC>GCG	p.A156A		NM_001004485	NP_001004485	Q8NGS4	O13F1_HUMAN	olfactory receptor, family 13, subfamily F,	156	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(1)|ovary(1)|skin(1)	3						GTCTCACTGCCATGGTGGAAA	0.478		NaN											0	0	0	0.038147	0	5	129									
CERCAM	51148	broad.mit.edu	37	9	131186476	131186476	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr9:131186476G>C	uc004buz.3	+	4	884	c.486G>C	c.(484-486)CAG>CAC	p.Q162H	CERCAM_uc004buy.1_Missense_Mutation_p.Q84H|CERCAM_uc010mxz.2_Missense_Mutation_p.Q84H|CERCAM_uc010mya.1_Missense_Mutation_p.Q3H	NM_016174	NP_057258	Q5T4B2	GT253_HUMAN	cerebral endothelial cell adhesion molecule 1	162					cellular component movement|leukocyte cell-cell adhesion|lipopolysaccharide biosynthetic process	endoplasmic reticulum lumen|plasma membrane				pancreas(1)	1						TCATGGGGCAGGGGCTTCCAG	0.612		NaN											0	0	0	0.02938	0	6	146									
SEC16A	9919	broad.mit.edu	37	9	139369336	139369336	+	Missense_Mutation	SNP	G	G	T			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr9:139369336G>T	uc004chx.2	-	3	3041	c.2732C>A	c.(2731-2733)TCT>TAT	p.S911Y	SEC16A_uc004chv.3_Intron|SEC16A_uc004chw.2_Missense_Mutation_p.S911Y|SEC16A_uc010nbn.2_Missense_Mutation_p.S911Y|SEC16A_uc010nbo.1_Missense_Mutation_p.S911Y	NM_014866	NP_055681	O15027	SC16A_HUMAN	SEC16 homolog A	733					protein transport|vesicle-mediated transport	endoplasmic reticulum membrane|Golgi membrane					0		Myeloproliferative disorder(178;0.0511)		Epithelial(140;2.9e-06)|OV - Ovarian serous cystadenocarcinoma(145;5.88e-06)		GGAAGCACCAGAACCTTGTGG	0.468		NaN											1	0	5.9392e-07	0.021553	6.74576e-07	5	93									
BMX	660	broad.mit.edu	37	X	15540611	15540611	+	Missense_Mutation	SNP	G	G	A			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chrX:15540611G>A	uc004cww.2	+	7	841	c.653G>A	c.(652-654)AGC>AAC	p.S218N	BMX_uc004cwx.3_Missense_Mutation_p.S218N|BMX_uc004cwy.3_Missense_Mutation_p.S218N	NM_203281	NP_975010	P51813	BMX_HUMAN	BMX non-receptor tyrosine kinase	218					cellular component disassembly involved in apoptosis|intracellular signal transduction|mesoderm development	cytosol	ATP binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity|protein binding|signal transducer activity			lung(3)|ovary(2)	5	Hepatocellular(33;0.183)					CAATATGACAGCAACTCAAAG	0.438		NaN											0	0	0	0.004672	0	3	67									
TAB3	257397	broad.mit.edu	37	X	30872793	30872793	+	Missense_Mutation	SNP	G	G	C			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chrX:30872793G>C	uc004dcj.2	-	6	1652	c.989C>G	c.(988-990)CCC>CGC	p.P330R	TAB3_uc004dck.2_Missense_Mutation_p.P330R|TAB3_uc010ngl.2_Missense_Mutation_p.P330R	NM_152787	NP_690000	Q8N5C8	TAB3_HUMAN	mitogen-activated protein kinase kinase kinase 7	330	Pro-rich.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein binding|zinc ion binding			ovary(1)	1						ATATGGATGGGGTGGAGTAGT	0.478		NaN											0	0	0	0.014758	0	5	40									
ZXDB	158586	broad.mit.edu	37	X	57619475	57619475	+	Missense_Mutation	SNP	C	C	T			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chrX:57619475C>T	uc004dvd.2	+	1	1207	c.994C>T	c.(994-996)CGG>TGG	p.R332W		NM_007157	NP_009088	P98169	ZXDB_HUMAN	zinc finger, X-linked, duplicated B	332	Required for interaction with ZXDC (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						CGACAAACTGCGGCCCTTTGG	0.602		NaN											0	0	0	0.004672	0	3	13									
PGK1	5230	broad.mit.edu	37	X	77372877	77372877	+	Silent	SNP	C	C	T			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chrX:77372877C>T	uc004ecz.3	+	5	658	c.486C>T	c.(484-486)GTC>GTT	p.V162V	PGK1_uc010nlz.2_RNA|PGK1_uc011mqq.1_Silent_p.V134V	NM_000291	NP_000282	P00558	PGK1_HUMAN	phosphoglycerate kinase 1	162					gluconeogenesis|glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			upper_aerodigestive_tract(1)|ovary(1)	2						ATGTCTATGTCAATGATGCTT	0.433		NaN											0	0	0	0.021553	0	4	45									
PANX2	56666	broad.mit.edu	37	22	50616632	50616633	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-FD-A3B8-01A-31D-A20D-08	TCGA-FD-A3B8-10A-01D-A20D-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7957bb77-8329-43a0-b1a8-140f2cb6b91b	83376d89-33f8-4ade-969d-d69391dd7cd8	g.chr22:50616632_50616633delTG	uc003bjn.3	+	2	1491_1492	c.1491_1492delTG	c.(1489-1494)CCTGCCfs	p.P497fs	PANX2_uc003bjp.3_Frame_Shift_Del_p.P363fs|PANX2_uc003bjo.3_Frame_Shift_Del_p.P497fs	NM_052839	NP_443071	Q96RD6	PANX2_HUMAN	pannexin 2 isoform 1	497_498	Cytoplasmic (Potential).				protein hexamerization|synaptic transmission	gap junction|integral to membrane	gap junction hemi-channel activity|ion channel activity			breast(1)	1		all_cancers(38;1.14e-10)|all_epithelial(38;2.12e-09)|all_lung(38;7.01e-05)|Breast(42;0.000523)|Lung NSC(38;0.0018)|Ovarian(80;0.0365)|Lung SC(80;0.113)		LUAD - Lung adenocarcinoma(64;0.105)		gccccgcccctgcccccgcccc	0.554		NaN											NaN	NaN	NaN	NaN	NaN	3	5	---	---							
