Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
CCNL2	81669	broad.mit.edu	37	1	1325721	1325721	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:1325721C>A	uc001afi.2	-	8	927	c.895G>T	c.(895-897)GAA>TAA	p.E299*	CCNL2_uc010nym.1_RNA|CCNL2_uc001aff.1_Nonsense_Mutation_p.E77*|CCNL2_uc001afg.1_Nonsense_Mutation_p.E77*|CCNL2_uc001afh.2_3'UTR|CCNL2_uc001afj.2_3'UTR|CCNL2_uc001afk.2_3'UTR	NM_030937	NP_112199	Q96S94	CCNL2_HUMAN	cyclin L2 isoform A	299					regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			ovary(2)|central_nervous_system(1)	3	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;8.75e-19)|all_lung(118;2.3e-08)|Lung NSC(185;2.38e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Lung SC(97;0.128)		Epithelial(90;2.03e-36)|OV - Ovarian serous cystadenocarcinoma(86;4.17e-22)|Colorectal(212;0.000159)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.0023)|BRCA - Breast invasive adenocarcinoma(365;0.00465)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0342)|Lung(427;0.146)		TTTCTTTTTTCCACTTCACCC	0.552		NaN											1	0	1.59361e-14	0.027894	1.70787e-14	35	56									
PGD	5226	broad.mit.edu	37	1	10471526	10471526	+	Missense_Mutation	SNP	G	G	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:10471526G>C	uc001arc.2	+	7	661	c.571G>C	c.(571-573)GAG>CAG	p.E191Q	PGD_uc001ard.2_Missense_Mutation_p.E111Q|PGD_uc010oak.1_Missense_Mutation_p.E169Q|PGD_uc010oal.1_Missense_Mutation_p.E178Q	NM_002631	NP_002622	P52209	6PGD_HUMAN	phosphogluconate dehydrogenase	191		Proton donor (By similarity).			pentose-phosphate shunt, oxidative branch	cytosol	NADP binding|phosphogluconate dehydrogenase (decarboxylating) activity|protein binding			ovary(1)	1	Ovarian(185;0.203)	all_lung(284;1.31e-05)|Lung NSC(185;2.19e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.14e-07)|COAD - Colon adenocarcinoma(227;7.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000294)|Kidney(185;0.000728)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|STAD - Stomach adenocarcinoma(132;0.00832)|READ - Rectum adenocarcinoma(331;0.0487)		CAACGGGATAGAGTATGGGGA	0.582		NaN											0	0	0	0.024245	0	13	45									
EIF4G3	8672	broad.mit.edu	37	1	21177865	21177865	+	Missense_Mutation	SNP	G	G	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:21177865G>C	uc001bec.2	-	23	3746	c.3490C>G	c.(3490-3492)CAG>GAG	p.Q1164E	EIF4G3_uc010odi.1_Missense_Mutation_p.Q768E|EIF4G3_uc010odj.1_Missense_Mutation_p.Q1163E|EIF4G3_uc009vpz.2_Missense_Mutation_p.Q884E|EIF4G3_uc001bed.2_Missense_Mutation_p.Q1164E|EIF4G3_uc001bef.2_Missense_Mutation_p.Q1200E|EIF4G3_uc001bee.2_Missense_Mutation_p.Q1170E	NM_003760	NP_003751	O43432	IF4G3_HUMAN	eukaryotic translation initiation factor 4	1164					interspecies interaction between organisms|regulation of translational initiation|RNA metabolic process	eukaryotic translation initiation factor 4F complex	protein binding|RNA cap binding|translation initiation factor activity			skin(1)	1		all_lung(284;2.61e-06)|Lung NSC(340;2.81e-06)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00149)|Ovarian(437;0.00338)|Myeloproliferative disorder(586;0.0256)		UCEC - Uterine corpus endometrioid carcinoma (279;0.023)|COAD - Colon adenocarcinoma(152;5.42e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000327)|GBM - Glioblastoma multiforme(114;0.000696)|Kidney(64;0.0018)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(64;0.0185)|READ - Rectum adenocarcinoma(331;0.124)|Lung(427;0.191)		TCTTGAGACTGATTGTCTAGC	0.522		NaN											0	0	0	0.013114	0	39	84									
ASAP3	55616	broad.mit.edu	37	1	23768756	23768756	+	Silent	SNP	G	G	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:23768756G>C	uc001bha.2	-	7	718	c.594C>G	c.(592-594)CTC>CTG	p.L198L	ASAP3_uc010odz.1_Silent_p.L67L|ASAP3_uc010oea.1_Silent_p.L189L	NM_017707	NP_060177	Q8TDY4	ASAP3_HUMAN	ArfGAP with SH3 domain, ankyrin repeat and PH	198					regulation of ARF GTPase activity	cytoplasm	ARF GTPase activator activity|zinc ion binding			large_intestine(1)|ovary(1)|skin(1)	3						CCCCGGCTTTGAGCAGATACT	0.567		NaN											0	0	0	0.021553	0	5	14									
ARID1A	8289	broad.mit.edu	37	1	27105793	27105793	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:27105793G>T	uc001bmv.1	+	20	5777	c.5404G>T	c.(5404-5406)GAG>TAG	p.E1802*	ARID1A_uc001bmu.1_Nonsense_Mutation_p.E1585*|ARID1A_uc001bmx.1_Nonsense_Mutation_p.E648*|ARID1A_uc009vsm.1_Nonsense_Mutation_p.E130*|ARID1A_uc009vsn.1_Nonsense_Mutation_p.E44*	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	1802					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		AGAGAATAGTGAGGAGAAGCT	0.438		NaN	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								1	0	2.23348e-06	0.028581	2.28993e-06	15	24									
ARID1A	8289	broad.mit.edu	37	1	27106492	27106492	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:27106492G>A	uc001bmv.1	+	20	6476	c.6103G>A	c.(6103-6105)GAG>AAG	p.E2035K	ARID1A_uc001bmu.1_Missense_Mutation_p.E1818K|ARID1A_uc001bmx.1_Missense_Mutation_p.E881K|ARID1A_uc009vsm.1_Missense_Mutation_p.E363K|ARID1A_uc009vsn.1_Missense_Mutation_p.E277K	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	2035					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TGAAAAGGAGGAGGAACAGGA	0.557		NaN	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								0	0	0	0.01441	0	49	69									
ARID1A	8289	broad.mit.edu	37	1	27106953	27106953	+	Missense_Mutation	SNP	G	G	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:27106953G>T	uc001bmv.1	+	20	6937	c.6564G>T	c.(6562-6564)CAG>CAT	p.Q2188H	ARID1A_uc001bmu.1_Missense_Mutation_p.Q1971H|ARID1A_uc001bmx.1_Missense_Mutation_p.Q1034H|ARID1A_uc009vsm.1_Missense_Mutation_p.Q516H|ARID1A_uc009vsn.1_Missense_Mutation_p.Q430H	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	2188					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TTGCAGTGCAGAAGGGCAGTA	0.627		NaN	Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								1	0	3.05275e-18	0.013114	3.2965e-18	41	106									
AK2	204	broad.mit.edu	37	1	33490112	33490112	+	Silent	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:33490112C>T	uc001bwp.1	-	2	192	c.150G>A	c.(148-150)CTG>CTA	p.L50L	uc001bwn.2_Intron|AK2_uc001bwo.1_Silent_p.L50L|AK2_uc010ohq.1_Silent_p.L50L|AK2_uc009vud.1_Intron|AK2_uc010ohr.1_Silent_p.L2L|AK2_uc001bwq.1_Silent_p.L2L	NM_001625	NP_001616	P54819	KAD2_HUMAN	adenylate kinase 2 isoform a	50	AMP (By similarity).				nucleobase, nucleoside and nucleotide interconversion	mitochondrial intermembrane space	adenylate kinase activity|ATP binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)				CCATGGCCCTCAGCATGTCCC	0.453		NaN											0	0	0	0.028581	0	16	29									
KIAA0754	643314	broad.mit.edu	37	1	39878981	39878981	+	Missense_Mutation	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:39878981C>T	uc009vvt.1	+	1	3806	c.3044C>T	c.(3043-3045)TCC>TTC	p.S1015F	MACF1_uc010ois.1_Intron|MACF1_uc001cda.1_Intron|MACF1_uc001cdc.1_Intron|MACF1_uc010oiu.1_Intron	NM_015038	NP_055853	O94854	K0754_HUMAN	hypothetical protein LOC643314	879	Ala-rich.|1.										0	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0393)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			GAGCCCACCTCCCCAGCTGCT	0.697		NaN											0	0	0	0.024245	0	12	17									
MACF1	23499	broad.mit.edu	37	1	39910468	39910468	+	Missense_Mutation	SNP	G	G	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:39910468G>T	uc010oiu.1	+	45	15026	c.14895G>T	c.(14893-14895)CAG>CAT	p.Q4965H	MACF1_uc010ois.1_Missense_Mutation_p.Q4463H	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			TTTTGGAGCAGAAGTGGCATG	0.438		NaN											1	0	2.48696e-23	0.015359	2.74823e-23	30	36									
LEPRE1	64175	broad.mit.edu	37	1	43232529	43232529	+	Silent	SNP	G	G	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:43232529G>C	uc001chv.2	-	1	227	c.114C>G	c.(112-114)CTC>CTG	p.L38L	LEPRE1_uc001chw.2_Silent_p.L38L|LEPRE1_uc001chx.3_Silent_p.L38L|LEPRE1_uc001chy.3_Silent_p.L38L|LEPRE1_uc001chz.2_Silent_p.L38L|C1orf50_uc001cia.3_5'Flank	NM_022356	NP_071751	Q32P28	P3H1_HUMAN	leprecan 1 isoform 1	38	TPR 1.				negative regulation of cell proliferation	endoplasmic reticulum|proteinaceous extracellular matrix	iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|procollagen-proline 3-dioxygenase activity			ovary(3)|lung(1)	4	Ovarian(52;0.00744)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)			L-Proline(DB00172)|Succinic acid(DB00139)|Vitamin C(DB00126)	CCTCGGCGAAGAGCAGATCAG	0.711		NaN											0	0	0	0.027894	0	33	53									
CACHD1	57685	broad.mit.edu	37	1	65095063	65095063	+	Missense_Mutation	SNP	C	C	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:65095063C>A	uc001dbo.1	+	5	495	c.390C>A	c.(388-390)AAC>AAA	p.N130K	CACHD1_uc001dbp.1_5'UTR|CACHD1_uc001dbq.1_5'UTR	NM_020925	NP_065976	Q5VU97	CAHD1_HUMAN	cache domain containing 1	181	Extracellular (Potential).				calcium ion transport	integral to membrane				ovary(2)	2						TGAAATCCAACCCTGGAATTA	0.453		NaN											1	0	6.38683e-12	0.008361	6.81902e-12	26	52									
ST6GALNAC3	256435	broad.mit.edu	37	1	77094406	77094406	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:77094406G>A	uc001dhh.2	+	5	996	c.833G>A	c.(832-834)AGG>AAG	p.R278K	ST6GALNAC3_uc010orh.1_Missense_Mutation_p.R177K	NM_152996	NP_694541	Q8NDV1	SIA7C_HUMAN	sialyltransferase 7C isoform 1	278	Lumenal (Potential).				protein glycosylation	integral to Golgi membrane	sialyltransferase activity			ovary(3)|skin(2)	5						GGGGGTCATAGGTTTATCACT	0.378		NaN											0	0	0	0.00499	0	16	32									
TMEM56	148534	broad.mit.edu	37	1	95609471	95609471	+	Missense_Mutation	SNP	C	C	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:95609471C>G	uc001drb.2	+	2	305	c.14C>G	c.(13-15)ACA>AGA	p.T5R	RWDD3_uc001drd.3_Missense_Mutation_p.T5R|TMEM56_uc001drc.2_Missense_Mutation_p.T5R	NM_152487	NP_689700	Q96MV1	TMM56_HUMAN	transmembrane protein 56	5						integral to membrane					0		all_lung(203;0.0232)|Lung NSC(277;0.0739)		all cancers(265;0.133)		GAGATCAACACAAAACTGCTC	0.313		NaN											0	0	0	0.014323	0	17	16									
PHTF1	10745	broad.mit.edu	37	1	114247322	114247322	+	Missense_Mutation	SNP	A	A	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:114247322A>C	uc009wgp.1	-	13	2221	c.1769T>G	c.(1768-1770)ATT>AGT	p.I590S	PHTF1_uc001edn.2_Missense_Mutation_p.I590S|PHTF1_uc001edm.2_Missense_Mutation_p.I347S	NM_006608	NP_006599	Q9UMS5	PHTF1_HUMAN	putative homeodomain transcription factor 1	590						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1	Lung SC(450;0.184)	all_cancers(81;3.78e-08)|all_epithelial(167;5.56e-08)|all_lung(203;6.97e-06)|Lung NSC(69;1.18e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		CCATATTTTAATATTCTCCAC	0.353		NaN											0	0	0	0.008291	0	10	25									
CSDE1	7812	broad.mit.edu	37	1	115261332	115261332	+	Missense_Mutation	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:115261332C>T	uc001efk.2	-	19	2717	c.2251G>A	c.(2251-2253)GAT>AAT	p.D751N	NRAS_uc009wgu.2_5'Flank|CSDE1_uc001efi.2_Missense_Mutation_p.D797N|CSDE1_uc001efj.2_RNA|CSDE1_uc001efl.2_Missense_Mutation_p.D720N|CSDE1_uc001efm.2_Missense_Mutation_p.D766N|CSDE1_uc009wgv.2_Missense_Mutation_p.D751N|CSDE1_uc001efn.2_Missense_Mutation_p.D720N	NM_001007553	NP_001007554	O75534	CSDE1_HUMAN	upstream of NRAS isoform 1	751					male gonad development|regulation of transcription, DNA-dependent	cytoplasm	DNA binding|protein binding|RNA binding			ovary(1)	1	all_epithelial(7;5.11e-05)|all_lung(7;0.000179)|Lung NSC(6;0.00195)|Lung SC(450;0.211)	all_cancers(81;2.21e-07)|all_epithelial(167;4.2e-07)|all_lung(203;9.97e-06)|Lung NSC(69;1.74e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|COAD - Colon adenocarcinoma(174;0.111)|all cancers(265;0.112)|Epithelial(280;0.124)|LUSC - Lung squamous cell carcinoma(189;0.133)		ACCAACCGATCAGGTCGAGGA	0.502		NaN											0	0	0	0.016723	0	12	31									
PTGFRN	5738	broad.mit.edu	37	1	117529499	117529499	+	Silent	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:117529499C>T	uc001egv.1	+	9	2687	c.2550C>T	c.(2548-2550)ATC>ATT	p.I850I		NM_020440	NP_065173	Q9P2B2	FPRP_HUMAN	prostaglandin F2 receptor negative regulator	850	Helical; (Potential).					endoplasmic reticulum membrane|Golgi apparatus|integral to membrane	protein binding			liver(1)	1	Lung SC(450;0.225)	all_cancers(81;0.00104)|all_lung(203;8.97e-05)|all_epithelial(167;0.000139)|Lung NSC(69;0.000446)		Lung(183;0.0704)|LUSC - Lung squamous cell carcinoma(189;0.227)|Colorectal(144;0.248)		CCTGTCTCATCGGGTACTGCA	0.607		NaN											0	0	0	0.01441	0	53	77									
CD5L	922	broad.mit.edu	37	1	157803159	157803159	+	Missense_Mutation	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:157803159C>T	uc001frk.3	-	5	1005	c.862G>A	c.(862-864)GGG>AGG	p.G288R		NM_005894	NP_005885	O43866	CD5L_HUMAN	CD5 molecule-like precursor	288	SRCR 3.				apoptosis|cellular defense response	extracellular space|membrane	scavenger receptor activity			ovary(1)	1	all_hematologic(112;0.0378)		LUSC - Lung squamous cell carcinoma(543;0.24)			AGGGACTTCCCACAGCCCAGT	0.587		NaN											0	0	0	0.013114	0	43	125									
MAEL	84944	broad.mit.edu	37	1	166973535	166973535	+	Silent	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:166973535C>T	uc001gdy.1	+	6	713	c.642C>T	c.(640-642)TAC>TAT	p.Y214Y	MAEL_uc001gdz.1_Silent_p.Y183Y|MAEL_uc009wvf.1_RNA	NM_032858	NP_116247	Q96JY0	MAEL_HUMAN	maelstrom homolog	214					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			skin(1)	1						CACCTATCTACTGCAAGGTAA	0.343		NaN											0	0	0	0.00308	0	5	31									
FMO3	2328	broad.mit.edu	37	1	171085395	171085395	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:171085395G>A	uc001ghi.2	+	8	1342	c.1231G>A	c.(1231-1233)GAG>AAG	p.E411K	FMO3_uc001ghh.2_Missense_Mutation_p.E411K|FMO3_uc010pmb.1_Missense_Mutation_p.E391K|FMO3_uc010pmc.1_Missense_Mutation_p.E348K	NM_001002294	NP_001002294	P31513	FMO3_HUMAN	flavin containing monooxygenase 3	411					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					TGATATTAATGAGAAAATGGA	0.358		NaN											0	0	0	0.020292	0	11	23									
C1orf9	51430	broad.mit.edu	37	1	172558282	172558282	+	Missense_Mutation	SNP	C	C	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:172558282C>G	uc001giq.3	+	18	2357	c.2041C>G	c.(2041-2043)CTG>GTG	p.L681V	C1orf9_uc010pmm.1_Missense_Mutation_p.L681V|C1orf9_uc009wwd.2_Missense_Mutation_p.L637V|C1orf9_uc010pmn.1_Intron|C1orf9_uc010pmo.1_RNA	NM_014283	NP_055098	Q9UBS9	OSPT_HUMAN	chromosome 1 open reading frame 9 protein	681					multicellular organismal development|ossification	integral to membrane|rough endoplasmic reticulum membrane				ovary(2)	2		Breast(1374;0.212)		Colorectal(1306;3.98e-05)|KIRC - Kidney renal clear cell carcinoma(1967;0.00544)		ATTGCAACCTCTGAGTGGAGA	0.408		NaN											0	0	0	0.007413	0	15	81									
SLC9A11	284525	broad.mit.edu	37	1	173517647	173517647	+	Missense_Mutation	SNP	C	C	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:173517647C>G	uc001giz.2	-	12	1765	c.1342G>C	c.(1342-1344)GCC>CCC	p.A448P	SLC9A11_uc009wwe.2_Missense_Mutation_p.A6P|SLC9A11_uc010pmq.1_RNA	NM_178527	NP_848622	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member 11	448					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity			ovary(2)	2						TGCTGAGTGGCATTTTGCAAG	0.363		NaN											0	0	0	0.006122	0	14	26									
CEP350	9857	broad.mit.edu	37	1	179989148	179989148	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:179989148C>T	uc001gnt.2	+	12	2622	c.2239C>T	c.(2239-2241)CAA>TAA	p.Q747*	CEP350_uc009wxl.2_Nonsense_Mutation_p.Q746*|CEP350_uc001gnu.2_Nonsense_Mutation_p.Q581*	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	747						centrosome|nucleus|spindle				ovary(4)	4						TCACCATTCTCAACCACAGCC	0.383		NaN											0	0	0	0.01441	0	45	92									
CEP350	9857	broad.mit.edu	37	1	180063622	180063622	+	Silent	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:180063622G>A	uc001gnt.2	+	34	8765	c.8382G>A	c.(8380-8382)AAG>AAA	p.K2794K	CEP350_uc009wxl.2_Silent_p.K2793K|CEP350_uc001gnv.2_Silent_p.K929K|CEP350_uc001gnw.1_Silent_p.K551K|CEP350_uc001gnx.1_Silent_p.K551K	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	2794						centrosome|nucleus|spindle				ovary(4)	4						ATGACCAAAAGAAAGTAACAC	0.388		NaN											0	0	0	0.014758	0	3	8									
PRG4	10216	broad.mit.edu	37	1	186276169	186276169	+	Missense_Mutation	SNP	C	C	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:186276169C>A	uc001gru.3	+	7	1369	c.1318C>A	c.(1318-1320)CCC>ACC	p.P440T	PRG4_uc001grt.3_Missense_Mutation_p.P399T|PRG4_uc009wyl.2_Missense_Mutation_p.P347T|PRG4_uc009wym.2_Missense_Mutation_p.P306T|PRG4_uc010poo.1_Intron	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	440	59 X 8 AA repeats of K-X-P-X-P-T-T-X.|12.				cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						ACCCACCACCCCCAAGAAGCC	0.652		NaN											1	0	0.000602214	0.014758	0.000608644	5	99									
CDC73	79577	broad.mit.edu	37	1	193121533	193121533	+	Missense_Mutation	SNP	A	A	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:193121533A>G	uc001gtb.2	+	10	1174	c.931A>G	c.(931-933)ACT>GCT	p.T311A		NM_024529	NP_078805	Q6P1J9	CDC73_HUMAN	parafibromin	311					cell cycle|histone H2B ubiquitination|histone monoubiquitination|transcription, DNA-dependent	Cdc73/Paf1 complex	protein binding			parathyroid(46)|ovary(1)|breast(1)|pancreas(1)	49						CAAAATTGACACTATGGGAAC	0.333		NaN							Hyperparathyroidism_Familial_Isolated|Hyperparathyroidism-Jaw_Tumor_Syndrome				0	0	0	0.028581	0	12	11									
FAM71A	149647	broad.mit.edu	37	1	212798352	212798352	+	Missense_Mutation	SNP	A	A	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:212798352A>T	uc001hjk.2	+	1	537	c.133A>T	c.(133-135)ATA>TTA	p.I45L	uc010pth.1_Intron	NM_153606	NP_705834	Q8IYT1	FA71A_HUMAN	hypothetical protein LOC149647	45										skin(3)|ovary(1)|central_nervous_system(1)	5				OV - Ovarian serous cystadenocarcinoma(81;0.00631)|all cancers(67;0.00981)|GBM - Glioblastoma multiforme(131;0.0715)|Epithelial(68;0.094)		GTATGCACCGATATTTGAGAG	0.512		NaN											0	0	0	0.01441	0	44	114									
C1orf69	200205	broad.mit.edu	37	1	228362441	228362441	+	Missense_Mutation	SNP	C	C	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:228362441C>A	uc001hsl.3	+	2	479	c.390C>A	c.(388-390)AGC>AGA	p.S130R	C1orf69_uc010pvw.1_5'UTR	NM_001010867	NP_001010867	Q5T440	CAF17_HUMAN	hypothetical protein LOC200205 precursor	130					glycine catabolic process|heme biosynthetic process	mitochondrion	aminomethyltransferase activity				0		Prostate(94;0.0405)				AGTGTGACAGCTCGGTGCAGG	0.662		NaN											1	0	0.00448238	0.004482	0.00451417	6	36									
OBSCN	84033	broad.mit.edu	37	1	228400372	228400372	+	Silent	SNP	C	C	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:228400372C>G	uc009xez.1	+	2	932	c.888C>G	c.(886-888)CTC>CTG	p.L296L	OBSCN_uc001hsn.2_Silent_p.L296L|uc001hsm.1_RNA	NM_001098623	NP_001092093	Q5VST9	OBSCN_HUMAN	obscurin, cytoskeletal calmodulin and	296	Ig-like 3.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|multicellular organismal development|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|M band|Z disc	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity|Rho guanyl-nucleotide exchange factor activity|structural constituent of muscle|titin binding			stomach(8)|large_intestine(7)|breast(5)|ovary(4)|skin(2)|central_nervous_system(1)|pancreas(1)	28		Prostate(94;0.0405)				ACTTCGTGCTCAAGATCCTCT	0.657		NaN											0	0	0	0.01441	0	42	110									
GALNT2	2590	broad.mit.edu	37	1	230398367	230398367	+	Missense_Mutation	SNP	C	C	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:230398367C>G	uc010pwa.1	+	12	1257	c.1185C>G	c.(1183-1185)TTC>TTG	p.F395L	GALNT2_uc010pvy.1_Missense_Mutation_p.F357L|GALNT2_uc010pvz.1_RNA|GALNT2_uc001htu.2_Missense_Mutation_p.F7L	NM_004481	NP_004472	Q10471	GALT2_HUMAN	polypeptide N-acetylgalactosaminyltransferase 2	395	Lumenal (Potential).				immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			ovary(2)	2	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				ACAAAAATTTCTATTATGCAG	0.448		NaN											0	0	0	0.01441	0	65	146									
OR2G3	81469	broad.mit.edu	37	1	247768909	247768909	+	Missense_Mutation	SNP	T	T	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:247768909T>A	uc010pyz.1	+	1	22	c.22T>A	c.(22-24)TCC>ACC	p.S8T		NM_001001914	NP_001001914	Q8NGZ4	OR2G3_HUMAN	olfactory receptor, family 2, subfamily G,	8	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			CAATGAGAGTTCCCTAATGGA	0.468		NaN											0	0	0	0.010818	0	23	37									
C10orf140	387640	broad.mit.edu	37	10	21804750	21804750	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr10:21804750C>A	uc009xkd.2	-	4	4255	c.2002G>T	c.(2002-2004)GAG>TAG	p.E668*	uc001iqp.1_Intron	NM_207371	NP_997254	Q1XH10	DLN1_HUMAN	hypothetical protein LOC387640	587						nucleus	nucleotide binding			ovary(1)	1						CAGGGATTCTCGGCTTTAGTT	0.433		NaN											1	0	9.16793e-09	0.00499	9.53733e-09	14	18									
BLOC1S2	282991	broad.mit.edu	37	10	102045870	102045870	+	Silent	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr10:102045870C>T	uc001kqw.1	-	2	179	c.156G>A	c.(154-156)CTG>CTA	p.L52L	BLOC1S2_uc001kqv.1_Silent_p.L9L	NM_173809	NP_776170	Q6QNY1	BL1S2_HUMAN	biogenesis of lysosome-related organelles	52					melanosome organization|microtubule nucleation|platelet dense granule organization|positive regulation of cell proliferation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|regulation of apoptosis	BLOC-1 complex|centrosome|gamma-tubulin complex|nucleus	gamma-tubulin binding|identical protein binding|protein C-terminus binding			ovary(1)	1		Colorectal(252;0.117)		Epithelial(162;2.44e-10)|all cancers(201;1.97e-08)		GTTCCCCAGTCAGGTAAGTGG	0.597		NaN											0	0	0	0.01441	0	70	167									
INPP5A	3632	broad.mit.edu	37	10	134591246	134591246	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr10:134591246G>A	uc001llp.2	+	13	1297	c.1049G>A	c.(1048-1050)CGC>CAC	p.R350H	INPP5A_uc001llo.1_Missense_Mutation_p.R350H|INPP5A_uc001llq.2_Missense_Mutation_p.R245H	NM_005539	NP_005530	Q14642	I5P1_HUMAN	inositol polyphosphate-5-phosphatase A	350					cell communication	membrane	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|PH domain binding			skin(1)	1		all_cancers(35;8.59e-13)|all_epithelial(44;5.49e-09)|Lung NSC(174;0.000854)|all_lung(145;0.00146)|all_neural(114;0.0299)|Colorectal(31;0.0599)|Breast(234;0.0849)|Melanoma(40;0.124)|all_hematologic(284;0.196)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;0.000102)|Epithelial(32;0.00023)|all cancers(32;0.000326)		TGGTGTGACCGCATCCTCATG	0.652		NaN											0	0	0	0.007835	0	36	56									
CDHR5	53841	broad.mit.edu	37	11	621088	621088	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:621088G>A	uc001lqj.2	-	7	886	c.781C>T	c.(781-783)CAC>TAC	p.H261Y	CDHR5_uc001lqk.2_Missense_Mutation_p.H261Y|CDHR5_uc009ycc.2_Missense_Mutation_p.H95Y|CDHR5_uc009ycd.2_Missense_Mutation_p.H261Y|CDHR5_uc001lql.2_Missense_Mutation_p.H261Y|CDHR5_uc001lqm.2_Missense_Mutation_p.H95Y|CDHR5_uc009yce.1_Missense_Mutation_p.H230Y	NM_021924	NP_068743	Q9HBB8	CDHR5_HUMAN	mucin and cadherin-like isoform 1	261	Cadherin 3.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0						ACCAGTATGTGCCCCGTGGGG	0.672		NaN											0	0	0	0.013726	0	28	49									
LRDD	55367	broad.mit.edu	37	11	801284	801284	+	Missense_Mutation	SNP	G	G	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:801284G>T	uc001lro.1	-	9	1706	c.1564C>A	c.(1564-1566)CAG>AAG	p.Q522K	LRDD_uc009yck.1_RNA|LRDD_uc001lrk.1_Missense_Mutation_p.Q522K|LRDD_uc001lrl.1_Missense_Mutation_p.Q376K|LRDD_uc001lrm.1_Missense_Mutation_p.Q209K|LRDD_uc001lrn.1_Missense_Mutation_p.Q376K|LRDD_uc001lrp.1_Missense_Mutation_p.Q160K	NM_145886	NP_665893	Q9HB75	PIDD_HUMAN	leucine rich repeat and death domain containing	522	ZU5 2.				apoptosis|signal transduction	cytoplasm|nucleus	death receptor binding				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GGACCGCTCTGTGACAGGCAC	0.677		NaN											1	0	7.63505e-26	0.012213	8.47013e-26	27	51									
NUP98	4928	broad.mit.edu	37	11	3720533	3720533	+	Missense_Mutation	SNP	C	C	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:3720533C>A	uc001lyh.2	-	25	4079	c.3788G>T	c.(3787-3789)TGG>TTG	p.W1263L	NUP98_uc001lyi.2_Missense_Mutation_p.W1263L|NUP98_uc001lyg.2_Missense_Mutation_p.W228L	NM_016320	NP_057404	P52948	NUP98_HUMAN	nucleoporin 98kD isoform 1	1280					carbohydrate metabolic process|DNA replication|glucose transport|interspecies interaction between organisms|mitotic prometaphase|mRNA transport|nuclear pore organization|protein import into nucleus, docking|regulation of glucose transport|transmembrane transport|viral reproduction	cytosol|nuclear membrane|nucleoplasm|Nup107-160 complex	protein binding|structural constituent of nuclear pore|transporter activity			breast(4)|skin(3)|ovary(2)|central_nervous_system(1)|lung(1)|kidney(1)	12		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0403)|LUSC - Lung squamous cell carcinoma(625;0.116)|Lung(200;0.199)		CAGGTGGCCccatagggcttc	0.299		NaN	T	HOXA9|NSD1|WHSC1L1|DDX10|TOP1|HOXD13|PMX1|HOXA13|HOXD11|HOXA11|RAP1GDS1|HOXC11	AML								1	0	5.73435e-26	0.01441	6.38649e-26	40	40									
ZNF214	7761	broad.mit.edu	37	11	7022651	7022651	+	Missense_Mutation	SNP	T	T	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:7022651T>G	uc001mfa.2	-	3	566	c.263A>C	c.(262-264)CAA>CCA	p.Q88P	ZNF214_uc010ray.1_Missense_Mutation_p.Q88P|ZNF214_uc009yfh.1_Missense_Mutation_p.Q88P	NM_013249	NP_037381	Q9UL59	ZN214_HUMAN	zinc finger protein 214	88					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1				Epithelial(150;3.87e-08)|BRCA - Breast invasive adenocarcinoma(625;0.081)		ATCTGTCCCTTGAACAGTTTC	0.438		NaN											0	0	0	0.01441	0	122	166									
MICAL2	9645	broad.mit.edu	37	11	12247845	12247845	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:12247845G>A	uc001mjz.2	+	14	2104	c.1816G>A	c.(1816-1818)GAC>AAC	p.D606N	MICAL2_uc010rch.1_Missense_Mutation_p.D606N|MICAL2_uc001mka.2_Missense_Mutation_p.D606N|MICAL2_uc010rci.1_Missense_Mutation_p.D606N|MICAL2_uc001mkb.2_Missense_Mutation_p.D606N|MICAL2_uc001mkc.2_Missense_Mutation_p.D606N|MICAL2_uc001mkd.2_Missense_Mutation_p.D435N|MICAL2_uc010rcj.1_Missense_Mutation_p.D8N	NM_014632	NP_055447	O94851	MICA2_HUMAN	microtubule associated monoxygenase, calponin	606	CH.					cytoplasm|cytoskeleton	monooxygenase activity|zinc ion binding			upper_aerodigestive_tract(2)	2				Epithelial(150;0.00552)		CCAGGAGCCTGACAAGCTCAG	0.572		NaN											0	0	0	0.010818	0	30	57									
KCNJ11	3767	broad.mit.edu	37	11	17409117	17409117	+	Silent	SNP	G	G	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:17409117G>T	uc001mna.2	-	1	1090	c.522C>A	c.(520-522)GCC>GCA	p.A174A	KCNJ11_uc001mnb.3_Silent_p.A87A	NM_000525	NP_000516	B4DWI4	B4DWI4_HUMAN	potassium inwardly-rectifying channel J11	174						integral to membrane	ATP-activated inward rectifier potassium channel activity			ovary(1)	1				READ - Rectum adenocarcinoma(2;0.0276)|Colorectal(2;0.0633)		CCCTGCGGTGGGCTTGGGCAG	0.597		NaN									OREG0020810	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	1	0	3.62473e-10	0.012319	3.82685e-10	17	21									
ANO3	63982	broad.mit.edu	37	11	26655840	26655840	+	Missense_Mutation	SNP	T	T	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:26655840T>C	uc001mqt.3	+	19	2108	c.1963T>C	c.(1963-1965)TAT>CAT	p.Y655H	ANO3_uc010rdr.1_Missense_Mutation_p.Y639H|ANO3_uc010rds.1_Missense_Mutation_p.Y494H|ANO3_uc010rdt.1_Missense_Mutation_p.Y509H	NM_031418	NP_113606	Q9BYT9	ANO3_HUMAN	transmembrane protein 16C	655	Helical; (Potential).					chloride channel complex	chloride channel activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TTCCATCTTCTATATCGCTTT	0.368		NaN											0	0	0	0.008291	0	10	11									
RAG1	5896	broad.mit.edu	37	11	36595001	36595001	+	Silent	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:36595001G>A	uc001mwu.3	+	2	271	c.147G>A	c.(145-147)AAG>AAA	p.K49K	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	49	Interaction with importin alpha-1.				histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				AAAAGGAAAAGAAGGATTCCT	0.438		NaN							Familial_Hemophagocytic_Lymphohistiocytosis				0	0	0	0.008291	0	11	23									
OR4C46	119749	broad.mit.edu	37	11	51515382	51515382	+	Missense_Mutation	SNP	T	T	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:51515382T>G	uc010ric.1	+	1	101	c.101T>G	c.(100-102)ATC>AGC	p.I34S		NM_001004703	NP_001004703	A6NHA9	O4C46_HUMAN	olfactory receptor, family 4, subfamily C,	34	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GTCATCTATATCATCACTGTG	0.433		NaN											0	0	0	0.01441	0	51	86									
OR5D18	219438	broad.mit.edu	37	11	55587569	55587569	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:55587569C>A	uc010rin.1	+	1	464	c.464C>A	c.(463-465)TCA>TAA	p.S155*		NM_001001952	NP_001001952	Q8NGL1	OR5DI_HUMAN	olfactory receptor, family 5, subfamily D,	155	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)|ovary(1)	3		all_epithelial(135;0.208)				TGGGGAGTCTCATGTTCCTTG	0.478		NaN											1	0	3.50607e-19	0.01441	3.80047e-19	42	70									
FAM111B	374393	broad.mit.edu	37	11	58893255	58893255	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:58893255G>A	uc001nnl.2	+	4	1928	c.1685G>A	c.(1684-1686)TGG>TAG	p.W562*	FAM111B_uc001nnm.2_Nonsense_Mutation_p.W532*|FAM111B_uc010rko.1_Nonsense_Mutation_p.W532*	NM_198947	NP_945185	Q6SJ93	F111B_HUMAN	hypothetical protein LOC374393 isoform a	562							catalytic activity	p.W562*(1)		ovary(2)	2						CCAGGACTATGGCGACAGATT	0.373		NaN											0	0	0	0.020292	0	14	37									
CD6	923	broad.mit.edu	37	11	60777201	60777201	+	Silent	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:60777201G>A	uc001nqq.2	+	5	1162	c.939G>A	c.(937-939)GAG>GAA	p.E313E	CD6_uc009yni.2_Intron|CD6_uc009ynj.2_Intron|CD6_uc001nqp.2_Silent_p.E313E|CD6_uc001nqr.2_Silent_p.E313E|CD6_uc001nqs.2_RNA|CD6_uc001nqt.2_Silent_p.E313E	NM_006725	NP_006716	P30203	CD6_HUMAN	CD6 molecule precursor	313	SRCR 3.|Extracellular (Potential).				cell adhesion	cell surface|integral to plasma membrane	scavenger receptor activity			pancreas(1)	1						CTGCGGTTGAGAGGCCCAAGG	0.592		NaN											0	0	0	0.013726	0	29	54									
DPP3	10072	broad.mit.edu	37	11	66262701	66262701	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:66262701G>A	uc001oig.1	+	13	1476	c.1414G>A	c.(1414-1416)GAC>AAC	p.D472N	DPP3_uc001oif.1_Missense_Mutation_p.D472N|DPP3_uc010rpe.1_Missense_Mutation_p.D461N|DPP3_uc001oih.1_5'Flank	NM_005700	NP_005691	Q9NY33	DPP3_HUMAN	dipeptidyl peptidase III	472					proteolysis	cytoplasm	aminopeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity			ovary(1)|skin(1)	2						ATTCAACTTTGACCAGGAAAC	0.627		NaN											0	0	0	0.01441	0	52	80									
BBS1	582	broad.mit.edu	37	11	66288833	66288833	+	Missense_Mutation	SNP	C	C	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:66288833C>G	uc001oij.1	+	9	828	c.816C>G	c.(814-816)ATC>ATG	p.I272M	BBS1_uc001oii.1_Missense_Mutation_p.I309M|BBS1_uc010rpf.1_RNA|BBS1_uc010rpg.1_Missense_Mutation_p.I175M|BBS1_uc001oik.1_Missense_Mutation_p.I196M|BBS1_uc001oil.1_Intron|ZDHHC24_uc001oim.1_RNA|ZDHHC24_uc009yrg.1_3'UTR|BBS1_uc010rph.1_5'Flank	NM_024649	NP_078925	Q8NFJ9	BBS1_HUMAN	Bardet-Biedl syndrome 1	272					nonmotile primary cilium assembly|photoreceptor cell maintenance|response to stimulus|retina homeostasis	BBSome|cilium membrane|cytoplasm	protein binding			ovary(1)	1						ATGGAAACATCTATATTCTGA	0.552		NaN							Bardet-Biedl_syndrome				0	0	0	0.007413	0	16	25									
PITPNM1	9600	broad.mit.edu	37	11	67262389	67262389	+	Missense_Mutation	SNP	C	C	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:67262389C>A	uc001olx.2	-	17	2859	c.2670G>T	c.(2668-2670)GAG>GAT	p.E890D	PITPNM1_uc001olw.2_Missense_Mutation_p.E172D|PITPNM1_uc001oly.2_Missense_Mutation_p.E890D|PITPNM1_uc001olz.2_Missense_Mutation_p.E889D	NM_004910	NP_004901	O00562	PITM1_HUMAN	phosphatidylinositol transfer protein,	890					brain development|lipid metabolic process|phototransduction|protein transport	cleavage furrow|endoplasmic reticulum membrane|Golgi cisterna membrane|lipid particle|membrane fraction|midbody	metal ion binding|phosphatidylinositol transporter activity			lung(2)|central_nervous_system(1)	3						TGGACGGCTCCTCGCATTCCG	0.692		NaN											1	0	1.21526e-53	0.01441	1.37504e-53	84	130									
LRP5	4041	broad.mit.edu	37	11	68174203	68174203	+	Silent	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:68174203C>T	uc001ont.2	+	9	2088	c.2013C>T	c.(2011-2013)CTC>CTT	p.L671L	LRP5_uc009ysg.2_Silent_p.L81L	NM_002335	NP_002326	O75197	LRP5_HUMAN	low density lipoprotein receptor-related protein	671	Beta-propeller 3.|Extracellular (Potential).				adipose tissue development|bone marrow development|bone morphogenesis|canonical Wnt receptor signaling pathway|cholesterol homeostasis|endocytosis|glucose catabolic process|negative regulation of osteoblast differentiation|negative regulation of protein serine/threonine kinase activity|positive regulation of fat cell differentiation|positive regulation of mesenchymal cell proliferation|positive regulation of mitosis|positive regulation of transcription from RNA polymerase II promoter|regulation of blood pressure|regulation of canonical Wnt receptor signaling pathway|retina morphogenesis in camera-type eye|retinal blood vessel morphogenesis|Wnt receptor signaling pathway involved in dorsal/ventral axis specification	endoplasmic reticulum|integral to membrane|plasma membrane|receptor complex	protein binding|receptor activity			lung(2)|skin(2)|ovary(1)|pancreas(1)|breast(1)	7						CCATCCCGCTCACGGGCGTCA	0.587		NaN											0	0	0	0.008291	0	10	29									
ANO1	55107	broad.mit.edu	37	11	70028637	70028637	+	Silent	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:70028637C>T	uc001opj.2	+	24	2738	c.2433C>T	c.(2431-2433)TTC>TTT	p.F811F	ANO1_uc001opl.1_RNA|ANO1_uc010rqk.1_Silent_p.F520F|ANO1_uc010rql.1_5'UTR	NM_018043	NP_060513	Q5XXA6	ANO1_HUMAN	anoctamin 1, calcium activated chloride channel	811	Helical; (Potential).				multicellular organismal development	chloride channel complex|cytoplasm|plasma membrane	intracellular calcium activated chloride channel activity			ovary(1)|pancreas(1)	2						CGTCTGACTTCATCCCGCGCC	0.612		NaN											0	0	0	0.00632	0	22	42									
RSF1	51773	broad.mit.edu	37	11	77411897	77411897	+	Missense_Mutation	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:77411897C>T	uc001oyn.2	-	6	2497	c.2377G>A	c.(2377-2379)GAT>AAT	p.D793N	RSF1_uc001oym.2_Missense_Mutation_p.D541N	NM_016578	NP_057662	Q96T23	RSF1_HUMAN	remodeling and spacing factor 1	793					CenH3-containing nucleosome assembly at centromere|negative regulation of DNA binding|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|positive regulation of viral transcription|transcription initiation, DNA-dependent	RSF complex	histone binding|protein binding|zinc ion binding			ovary(2)|central_nervous_system(2)	4	all_cancers(14;1.54e-17)|all_epithelial(13;4.06e-20)|Ovarian(111;0.152)		Epithelial(5;3e-50)|all cancers(3;6.37e-47)|BRCA - Breast invasive adenocarcinoma(5;9.82e-31)			GCTTTCTGATCTCTGATCTCA	0.383		NaN											0	0	0	0.008871	0	18	27									
JRKL	8690	broad.mit.edu	37	11	96124087	96124087	+	Missense_Mutation	SNP	G	G	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:96124087G>C	uc009ywu.2	+	2	526	c.274G>C	c.(274-276)GCA>CCA	p.A92P	CCDC82_uc001pfx.3_5'Flank|CCDC82_uc009ywr.2_5'Flank|CCDC82_uc009ywt.1_5'Flank|JRKL_uc001pfy.2_Missense_Mutation_p.A92P	NM_003772	NP_003763	Q9Y4A0	JERKL_HUMAN	jerky homolog-like	92	HTH CENPB-type.				central nervous system development|regulation of transcription, DNA-dependent	chromosome, centromeric region|nucleus	DNA binding				0		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)		BRCA - Breast invasive adenocarcinoma(274;0.148)		CCAGCAAAGAGCAAAAGGGAA	0.443		NaN											0	0	0	0.01441	0	46	17									
IL10RA	3587	broad.mit.edu	37	11	117866303	117866303	+	Splice_Site	SNP	G	G	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:117866303G>T	uc001prv.2	+	6	766	c.689_splice	c.e6-1	p.Y230_splice	IL10RA_uc010rxl.1_Splice_Site_p.Y210_splice|IL10RA_uc010rxm.1_Splice_Site_p.Y210_splice|IL10RA_uc010rxn.1_Splice_Site_p.Y81_splice|IL10RA_uc001prw.2_Splice_Site_p.Y81_splice	NM_001558	NP_001549	Q13651	I10R1_HUMAN	interleukin 10 receptor, alpha precursor							integral to membrane|plasma membrane	interleukin-10 receptor activity			ovary(1)	1	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.07e-05)|Epithelial(105;0.00108)		TGGGCCTGCAGATTTCACCGT	0.577		NaN											1	0	9.50027e-55	0.01441	1.07923e-54	94	24									
MLL	4297	broad.mit.edu	37	11	118355688	118355688	+	Missense_Mutation	SNP	G	G	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08			G	C	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:118355688G>C	uc001pta.2	+	10	4353	c.4330G>C	c.(4330-4332)GAG>CAG	p.E1444Q	MLL_uc001ptb.2_Missense_Mutation_p.E1444Q|MLL_uc001pte.1_Intron	NM_005933	NP_005924	Q03164	MLL1_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	1444	PHD-type 1.	Breakpoint for translocation to form MLL- LPP.|Breakpoint for translocation to form MLL- GAS7 oncogene.			apoptosis|embryonic hemopoiesis|histone H4-K16 acetylation|positive regulation of transcription, DNA-dependent|protein complex assembly|transcription from RNA polymerase II promoter	MLL1 complex	AT DNA binding|histone acetyl-lysine binding|histone methyltransferase activity (H3-K4 specific)|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|unmethylated CpG binding|zinc ion binding			lung(7)|ovary(5)|kidney(5)|central_nervous_system(3)|pancreas(2)|urinary_tract(1)|breast(1)|skin(1)	25	all_hematologic(175;0.046)	all_hematologic(192;1.13e-50)|all_neural(223;3.18e-06)|Breast(348;1.07e-05)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.244)		OV - Ovarian serous cystadenocarcinoma(223;2.77e-44)|BRCA - Breast invasive adenocarcinoma(274;1.2e-11)|Lung(307;3.48e-06)|LUSC - Lung squamous cell carcinoma(976;7.92e-05)|Colorectal(284;0.144)		TGGGCATGTAGAGGTAAGGCA	0.423		NaN	T|O	MLL|MLLT1|MLLT2|MLLT3|MLLT4|MLLT7|MLLT10|MLLT6|ELL|EPS15|AF1Q|CREBBP|SH3GL1|FNBP1|PNUTL1|MSF|GPHN|GMPS|SSH3BP1|ARHGEF12|GAS7|FOXO3A|LAF4|LCX|SEPT6|LPP|CBFA2T1|GRAF|EP300|PICALM|HEAB	AML|ALL								0	0	0	0.010729	0	12	21									
OR8A1	390275	broad.mit.edu	37	11	124440079	124440079	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:124440079G>A	uc010san.1	+	1	115	c.115G>A	c.(115-117)GAC>AAC	p.D39N		NM_001005194	NP_001005194	Q8NGG7	OR8A1_HUMAN	olfactory receptor, family 8, subfamily A,	39	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0214)		GAAGAGAGCAGACCTCCAGCT	0.527		NaN											0	0	0	0.006122	0	15	28									
ARHGAP32	9743	broad.mit.edu	37	11	128844063	128844063	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:128844063G>C	uc009zcp.2	-	20	2987	c.2987C>G	c.(2986-2988)TCA>TGA	p.S996*	ARHGAP32_uc009zcq.1_Nonsense_Mutation_p.S956*|ARHGAP32_uc009zco.2_5'UTR|ARHGAP32_uc001qez.2_Nonsense_Mutation_p.S647*	NM_001142685	NP_001136157	A7KAX9	RHG32_HUMAN	Rho GTPase-activating protein isoform 1	996					cell communication|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cell cortex|cell junction|cytosol|dendritic spine|endoplasmic reticulum membrane|endosome membrane|Golgi membrane|postsynaptic density|postsynaptic membrane	GTPase activator activity|phosphatidylinositol binding			lung(3)|ovary(2)	5						CTGACTGCTTGAGACAGACTG	0.473		NaN											0	0	0	0.010504	0	21	43									
SPATA19	219938	broad.mit.edu	37	11	133715054	133715054	+	Missense_Mutation	SNP	G	G	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:133715054G>C	uc001qgv.1	-	2	161	c.110C>G	c.(109-111)TCT>TGT	p.S37C		NM_174927	NP_777587	Q7Z5L4	SPT19_HUMAN	spermatogenesis associated 19 precursor	37					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrial outer membrane					0	all_hematologic(175;0.127)	all_cancers(12;5.59e-17)|all_epithelial(12;2.65e-12)|all_lung(97;0.00045)|Lung NSC(97;0.000861)|Breast(109;0.000873)|Medulloblastoma(222;0.0425)|Esophageal squamous(93;0.0844)|all_neural(223;0.117)		Epithelial(10;4.36e-10)|all cancers(11;7.1e-09)|BRCA - Breast invasive adenocarcinoma(10;8.45e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00286)|Lung(977;0.207)		ATGTAGTACAGACACAGCCTC	0.458		NaN											0	0	0	0.011902	0	34	60									
A2M	2	broad.mit.edu	37	12	9248286	9248286	+	Missense_Mutation	SNP	A	A	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr12:9248286A>G	uc001qvk.1	-	16	1975	c.1862T>C	c.(1861-1863)CTG>CCG	p.L621P	A2M_uc009zgk.1_Missense_Mutation_p.L471P	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	621					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	TTCTGGTAGCAGGTTGTAAAC	0.308		NaN											0	0	0	0.007413	0	12	58									
PTPRO	5800	broad.mit.edu	37	12	15677896	15677896	+	Missense_Mutation	SNP	G	G	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr12:15677896G>C	uc001rcv.1	+	11	2214	c.2040G>C	c.(2038-2040)AAG>AAC	p.K680N	PTPRO_uc001rcw.1_Missense_Mutation_p.K680N	NM_030667	NP_109592	Q16827	PTPRO_HUMAN	receptor-type protein tyrosine phosphatase O	680	Fibronectin type-III 7.|Extracellular (Potential).					integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			skin(5)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)	9		Hepatocellular(102;0.244)				AAATTAAAAAGAGTGTATGTT	0.289		NaN											0	0	0	0.010729	0	10	31									
PDE3A	5139	broad.mit.edu	37	12	20766459	20766459	+	Missense_Mutation	SNP	C	C	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr12:20766459C>G	uc001reh.1	+	3	1116	c.1094C>G	c.(1093-1095)TCT>TGT	p.S365C		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	365				HGLITDLLADPSLPPNVC -> TASLPTSWQTLLFHQTCA (in Ref. 3 and 4).	lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	GCAGACCCTTCTCTTCCACCA	0.557		NaN											0	0	0	0.01441	0	60	45									
ABCC9	10060	broad.mit.edu	37	12	22059097	22059097	+	Silent	SNP	A	A	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr12:22059097A>G	uc001rfi.1	-	10	1601	c.1581T>C	c.(1579-1581)TCT>TCC	p.S527S	ABCC9_uc001rfh.2_Silent_p.S527S|ABCC9_uc001rfj.1_Silent_p.S527S	NM_005691	NP_005682	O60706	ABCC9_HUMAN	ATP-binding cassette, sub-family C, member 9	527	Cytoplasmic (Potential).|ABC transmembrane type-1 1.				defense response to virus|potassium ion import	ATP-sensitive potassium channel complex	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium channel regulator activity|sulfonylurea receptor activity			ovary(4)|skin(2)	6					Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TTTTGAGACTAGATAGTTCTT	0.368		NaN											0	0	0	0.027356	0	18	45									
NCKAP5L	57701	broad.mit.edu	37	12	50189001	50189001	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr12:50189001G>C	uc009zlk.2	-	8	2844	c.2642C>G	c.(2641-2643)TCA>TGA	p.S881*	NCKAP5L_uc001rvc.3_Nonsense_Mutation_p.S85*|NCKAP5L_uc001rvb.2_Nonsense_Mutation_p.S474*	NM_001037806	NP_001032895	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	877										central_nervous_system(1)	1						CTCGATGGCTGAGTGTGGGGC	0.662		NaN											0	0	0	0.01441	0	94	72									
BIN2	51411	broad.mit.edu	37	12	51707619	51707619	+	Silent	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr12:51707619G>A	uc001ryg.2	-	2	202	c.150C>T	c.(148-150)TTC>TTT	p.F50F	BIN2_uc009zlz.2_Silent_p.F50F|BIN2_uc001ryh.2_5'UTR|BIN2_uc010sng.1_Silent_p.F24F	NM_016293	NP_057377	Q9UBW5	BIN2_HUMAN	bridging integrator 2	50	BAR.					cytoplasm	protein binding			ovary(1)	1						GTTGTTGGTAGAAGTTGCTAG	0.468		NaN											0	0	0	0.027894	0	34	43									
KRT79	338785	broad.mit.edu	37	12	53215788	53215788	+	Silent	SNP	C	C	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr12:53215788C>G	uc001sbb.2	-	9	1509	c.1476G>C	c.(1474-1476)GGG>GGC	p.G492G	KRT79_uc001sba.2_Silent_p.G263G	NM_175834	NP_787028	Q5XKE5	K2C79_HUMAN	keratin 6L	492	Tail.					keratin filament	structural molecule activity			ovary(2)|skin(2)	4						CCCCCCCACTCCCACCCAGGG	0.612		NaN											0	0	0	0.009718	0	39	55									
GLI1	2735	broad.mit.edu	37	12	57861869	57861869	+	Silent	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr12:57861869C>T	uc001snx.2	+	10	1248	c.1170C>T	c.(1168-1170)GAC>GAT	p.D390D	GLI1_uc009zpq.2_Silent_p.D262D	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	390					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)			ATGGTCCTGACGCCCATGTGA	0.572		NaN											0	0	0	0.027356	0	23	67									
LRRIQ1	84125	broad.mit.edu	37	12	85450509	85450509	+	Silent	SNP	A	A	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr12:85450509A>G	uc001tac.2	+	8	2049	c.1938A>G	c.(1936-1938)CCA>CCG	p.P646P	LRRIQ1_uc001tab.1_Silent_p.P646P|LRRIQ1_uc001taa.1_Silent_p.P621P	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	646										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		AGGAGAACCCAAAAGACAATG	0.308		NaN											0	0	0	0.021553	0	6	13									
C12orf42	374470	broad.mit.edu	37	12	103699968	103699968	+	Missense_Mutation	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr12:103699968C>T	uc001tjt.2	-	5	503	c.415G>A	c.(415-417)GAG>AAG	p.E139K	C12orf42_uc001tjs.2_Intron|C12orf42_uc009zuf.1_Missense_Mutation_p.E139K|C12orf42_uc001tju.2_Missense_Mutation_p.E44K	NM_198521	NP_940923	Q96LP6	CL042_HUMAN	hypothetical protein LOC374470	139										ovary(1)|central_nervous_system(1)	2						AATGGGGCCTCATCAGTTTCA	0.463		NaN											0	0	0	0.010504	0	17	14									
TBX5	6910	broad.mit.edu	37	12	114832653	114832653	+	Missense_Mutation	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr12:114832653C>T	uc001tvo.2	-	6	1051	c.556G>A	c.(556-558)GTG>ATG	p.V186M	TBX5_uc001tvp.2_Missense_Mutation_p.V186M|TBX5_uc001tvq.2_Missense_Mutation_p.V136M|TBX5_uc010syv.1_Missense_Mutation_p.V186M	NM_181486	NP_852259	Q99593	TBX5_HUMAN	T-box 5 isoform 1	186	T-box.				cardiac left ventricle formation|cell migration involved in coronary vasculogenesis|cell-cell signaling|embryonic arm morphogenesis|induction of apoptosis|negative regulation of cardiac muscle cell proliferation|negative regulation of cell migration|negative regulation of epithelial to mesenchymal transition|pericardium development|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|ventricular septum development	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(6)|pancreas(1)|skin(1)	8	Medulloblastoma(191;0.163)|all_neural(191;0.178)			BRCA - Breast invasive adenocarcinoma(302;0.0893)		TCCGCTTTCACGATGTGTAAT	0.363		NaN											0	0	0	0.01441	0	109	101									
DNAH10	196385	broad.mit.edu	37	12	124345628	124345628	+	Silent	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr12:124345628C>T	uc001uft.3	+	38	6490	c.6465C>T	c.(6463-6465)ATC>ATT	p.I2155I		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2155	AAA 2 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TCTACGGCATCCTGGACCCAA	0.488		NaN											0	0	0	0.015359	0	31	36									
PIWIL1	9271	broad.mit.edu	37	12	130834457	130834457	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr12:130834457G>A	uc001uik.2	+	9	1079	c.989G>A	c.(988-990)AGC>AAC	p.S330N	PIWIL1_uc001uij.1_Missense_Mutation_p.S330N	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	330	PAZ.				gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		AATCCCAAGAGCACCTTTAAG	0.408		NaN											0	0	0	0.00499	0	14	46									
FLT3	2322	broad.mit.edu	37	13	28597565	28597565	+	Missense_Mutation	SNP	C	C	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr13:28597565C>G	uc001urw.2	-	19	2422	c.2340G>C	c.(2338-2340)TTG>TTC	p.L780F	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Missense_Mutation_p.L780F	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	780	Protein kinase.|Cytoplasmic (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	TAAGCACATTCAAGTCCTCCT	0.353		NaN	Mis|O		AML|ALL								0	0	0	0.00308	0	7	25									
FRY	10129	broad.mit.edu	37	13	32783164	32783164	+	Missense_Mutation	SNP	C	C	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr13:32783164C>G	uc001utx.2	+	32	4689	c.4193C>G	c.(4192-4194)TCT>TGT	p.S1398C	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	1398					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		GTGACTGCTTCTCACGGGCTG	0.592		NaN											0	0	0	0.027894	0	38	91									
ALG5	29880	broad.mit.edu	37	13	37563687	37563687	+	Silent	SNP	A	A	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr13:37563687A>G	uc001uvy.2	-	5	448	c.381T>C	c.(379-381)TAT>TAC	p.Y127Y	ALG5_uc010teq.1_Silent_p.Y97Y|ALG5_uc010ter.1_RNA	NM_013338	NP_037470	Q9Y673	ALG5_HUMAN	dolichyl-phosphate beta-glucosyltransferase	127	Lumenal (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	dolichyl-phosphate beta-glucosyltransferase activity|oligosaccharyl transferase activity				0		Breast(139;0.014)|Lung SC(185;0.0548)|Prostate(109;0.174)		all cancers(112;5.79e-07)|Epithelial(112;1.81e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00785)|BRCA - Breast invasive adenocarcinoma(63;0.0127)|GBM - Glioblastoma multiforme(144;0.0472)		TGTCACTTCCATATTTCTGGC	0.284		NaN											0	0	0	0.016522	0	19	34									
TSC22D1	8848	broad.mit.edu	37	13	45147390	45147390	+	Missense_Mutation	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr13:45147390C>T	uc001uzn.3	-	1	3312	c.2821G>A	c.(2821-2823)GGG>AGG	p.G941R	TSC22D1_uc001uzo.1_Intron	NM_183422	NP_904358	Q15714	T22D1_HUMAN	TSC22 domain family, member 1 isoform 1	941					transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding transcription factor activity				0		all_hematologic(4;8.74e-08)|Acute lymphoblastic leukemia(4;1.78e-07)|Lung NSC(96;2.21e-05)|Breast(139;0.000625)|Prostate(109;0.000947)|Hepatocellular(98;0.0202)|Lung SC(185;0.0262)		GBM - Glioblastoma multiforme(144;0.000522)|BRCA - Breast invasive adenocarcinoma(63;0.118)		CTGCTACTCCCATCTGAAACT	0.547		NaN											0	0	0	0.010818	0	30	16									
DACH1	1602	broad.mit.edu	37	13	72440381	72440381	+	Nonsense_Mutation	SNP	G	G	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr13:72440381G>C	uc010thn.1	-	2	944	c.521C>G	c.(520-522)TCA>TGA	p.S174*	DACH1_uc010tho.1_Nonsense_Mutation_p.S174*|DACH1_uc010thp.1_Nonsense_Mutation_p.S174*	NM_080759	NP_542937	Q9UI36	DACH1_HUMAN	dachshund homolog 1 isoform a	174					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleolus	DNA binding|nucleotide binding|protein binding			breast(1)	1		Acute lymphoblastic leukemia(28;0.0503)|Breast(118;0.198)		GBM - Glioblastoma multiforme(99;0.00032)		GGACGGGGTTGAGTACACGGG	0.398		NaN											0	0	0	0.021553	0	6	14									
KLF5	688	broad.mit.edu	37	13	73636090	73636090	+	Missense_Mutation	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr13:73636090C>T	uc001vje.2	+	2	677	c.353C>T	c.(352-354)TCA>TTA	p.S118L	KLF5_uc001vjd.2_Missense_Mutation_p.S27L	NM_001730	NP_001721	Q13887	KLF5_HUMAN	Kruppel-like factor 5	118					transcription from RNA polymerase II promoter	nucleus	DNA binding|zinc ion binding			large_intestine(1)|ovary(1)|pancreas(1)	3		Prostate(6;0.00187)|Breast(118;0.0735)		GBM - Glioblastoma multiforme(99;0.0011)		GACAGTGCCTCAGTCGTAGAC	0.443		NaN											0	0	0	0.027894	0	33	110									
RBM26	64062	broad.mit.edu	37	13	79942951	79942951	+	Missense_Mutation	SNP	C	C	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr13:79942951C>A	uc001vkz.2	-	6	823	c.809G>T	c.(808-810)AGT>ATT	p.S270I	RBM26_uc001vky.2_Missense_Mutation_p.S270I|RBM26_uc001vla.2_Missense_Mutation_p.S270I|RBM26_uc001vkx.2_5'UTR|RBM26_uc001vlb.1_RNA	NM_022118	NP_071401	Q5T8P6	RBM26_HUMAN	RNA binding motif protein 26	270					mRNA processing		nucleotide binding|protein binding|RNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(28;0.0279)		GBM - Glioblastoma multiforme(99;0.0188)		TTCAGACCAACTTTCGGTAGT	0.433		NaN											1	0	9.14704e-12	0.00874	9.72944e-12	37	67									
KDELC1	79070	broad.mit.edu	37	13	103445990	103445990	+	Silent	SNP	C	C	T	rs144061173		TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr13:103445990C>T	uc001vpq.3	-	3	939	c.555G>A	c.(553-555)CAG>CAA	p.Q185Q	KDELC1_uc001vpr.3_5'UTR	NM_024089	NP_076994	Q6UW63	KDEL1_HUMAN	KDEL (Lys-Asp-Glu-Leu) containing 1 precursor	185						endoplasmic reticulum lumen				ovary(1)	1	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					GGCTCTGCCTCTGTCCAAATC	0.383		NaN											0	0	0	0.023175	0	34	84									
POTEG	404785	broad.mit.edu	37	14	19553758	19553758	+	Missense_Mutation	SNP	G	G	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr14:19553758G>C	uc001vuz.1	+	1	394	c.342G>C	c.(340-342)AAG>AAC	p.K114N	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	114										ovary(1)	1						GGAGCGGCAAGAGCAAAGTGG	0.597		NaN											0	0	0	0.01441	0	61	680									
SYNE2	23224	broad.mit.edu	37	14	64690078	64690078	+	Missense_Mutation	SNP	A	A	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr14:64690078A>G	uc001xgm.2	+	112	20523	c.20293A>G	c.(20293-20295)ATG>GTG	p.M6765V	SYNE2_uc001xgl.2_Missense_Mutation_p.M6788V|SYNE2_uc010apy.2_Missense_Mutation_p.M3150V|SYNE2_uc001xgn.2_Missense_Mutation_p.M1727V|SYNE2_uc001xgo.2_RNA|SYNE2_uc010aqa.2_Missense_Mutation_p.M735V|SYNE2_uc001xgq.2_Missense_Mutation_p.M1144V|SYNE2_uc001xgr.2_Missense_Mutation_p.M548V|SYNE2_uc010tsi.1_Missense_Mutation_p.M422V|SYNE2_uc001xgs.2_Missense_Mutation_p.M436V|SYNE2_uc001xgt.2_Missense_Mutation_p.M310V	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	6765	Potential.|Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CCAAGATTTAATGGCCTTGCA	0.428		NaN											0	0	0	0.00499	0	15	28									
PAPOLA	10914	broad.mit.edu	37	14	97022284	97022284	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr14:97022284G>A	uc001yfq.2	+	18	1975	c.1765G>A	c.(1765-1767)GGT>AGT	p.G589S	PAPOLA_uc001yfr.2_Missense_Mutation_p.G588S|PAPOLA_uc010twv.1_Missense_Mutation_p.G589S|PAPOLA_uc010avp.2_Missense_Mutation_p.G339S	NM_032632	NP_116021	P51003	PAPOA_HUMAN	poly(A) polymerase alpha	589	Ser/Thr-rich.				mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cytoplasm|nucleoplasm	ATP binding|magnesium ion binding|manganese ion binding|polynucleotide adenylyltransferase activity|RNA binding				0		all_cancers(154;0.0555)|all_epithelial(191;0.149)|Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.213)		AAGCTCAGGGGGTAAGGAGAT	0.403		NaN											0	0	0	0.015359	0	32	29									
DYNC1H1	1778	broad.mit.edu	37	14	102461424	102461424	+	Silent	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr14:102461424G>A	uc001yks.2	+	14	3599	c.3435G>A	c.(3433-3435)CAG>CAA	p.Q1145Q		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	1145	Stem (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						TCCATTCCCAGATCTCAAAGG	0.463		NaN											0	0	0	0.012319	0	21	35									
DYNC1H1	1778	broad.mit.edu	37	14	102476256	102476256	+	Missense_Mutation	SNP	G	G	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr14:102476256G>C	uc001yks.2	+	30	6218	c.6054G>C	c.(6052-6054)ATG>ATC	p.M2018I		NM_001376	NP_001367	Q14204	DYHC1_HUMAN	cytoplasmic dynein 1 heavy chain 1	2018	AAA 1 (By similarity).				cytoplasmic mRNA processing body assembly|G2/M transition of mitotic cell cycle|microtubule-based movement|mitotic spindle organization|stress granule assembly|transport	centrosome|cytoplasmic dynein complex|cytosol|Golgi apparatus|microtubule	ATP binding|ATPase activity, coupled|microtubule motor activity|protein binding			ovary(7)|central_nervous_system(2)|pancreas(1)	10						TCATCACCATGAACCCTGGCT	0.547		NaN											0	0	0	0.017118	0	31	50									
RORA	6095	broad.mit.edu	37	15	60919554	60919554	+	Missense_Mutation	SNP	C	C	T	rs139672315	by1000genomes	TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr15:60919554C>T	uc002agv.2	-	1	176	c.20G>A	c.(19-21)GGA>GAA	p.G7E	RORA_uc002agw.2_Missense_Mutation_p.G7E|RORA_uc002agx.2_Intron	NM_134260	NP_599022	P35398	RORA_HUMAN	RAR-related orphan receptor A isoform b	7	Modulating.				positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			large_intestine(1)|ovary(1)	2						GTCACTGTCTCCTGGGGCCCC	0.547		NaN											0	0	0	0.01441	0	44	87									
SV2B	9899	broad.mit.edu	37	15	91769539	91769539	+	Missense_Mutation	SNP	A	A	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr15:91769539A>G	uc002bqv.2	+	1	437	c.46A>G	c.(46-48)AGT>GGT	p.S16G	SV2B_uc002bqt.2_Missense_Mutation_p.S16G|SV2B_uc010uqv.1_Intron|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	16	Cytoplasmic (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			CTATGCTCCCAGTGATGGCTA	0.522		NaN											0	0	0	0.014323	0	20	30									
MLST8	64223	broad.mit.edu	37	16	2256159	2256159	+	Missense_Mutation	SNP	C	C	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr16:2256159C>G	uc002coz.2	+	2	192	c.73C>G	c.(73-75)CGC>GGC	p.R25G	MLST8_uc002coy.2_Missense_Mutation_p.R25G|MLST8_uc002cpa.2_5'UTR|MLST8_uc002cpb.2_Missense_Mutation_p.R25G|MLST8_uc010uvx.1_5'UTR|MLST8_uc002cpc.2_Missense_Mutation_p.R25G|MLST8_uc002cpd.2_5'UTR|MLST8_uc002cpe.2_Missense_Mutation_p.R25G|MLST8_uc010uvy.1_Missense_Mutation_p.R25G|MLST8_uc002cpg.2_Missense_Mutation_p.R44G|MLST8_uc002cph.2_RNA|MLST8_uc002cpf.2_Missense_Mutation_p.R25G	NM_022372	NP_071767	Q9BVC4	LST8_HUMAN	G protein beta subunit-like	25	WD 1.				insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of TOR signaling cascade|T cell costimulation	cytosol	protein binding				0						CCACACCGTGCGCTTCTGGCA	0.706		NaN											0	0	0	0.01441	0	46	64									
PRSS8	5652	broad.mit.edu	37	16	31144121	31144121	+	Silent	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr16:31144121G>A	uc002ebc.3	-	4	752	c.420C>T	c.(418-420)CTC>CTT	p.L140L	PRSS8_uc010vfe.1_Silent_p.L86L	NM_002773	NP_002764	Q16651	PRSS8_HUMAN	prostasin preproprotein	140	Peptidase S1.				proteolysis	extracellular space|integral to membrane|plasma membrane	serine-type endopeptidase activity				0						TGGGTCTGCTGAGTTGGAGGA	0.642		NaN											0	0	0	0.01441	0	279	88									
FUS	2521	broad.mit.edu	37	16	31202302	31202302	+	Missense_Mutation	SNP	A	A	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr16:31202302A>G	uc002ebf.2	+	14	1495	c.1412A>G	c.(1411-1413)GAT>GGT	p.D471G	FUS_uc002ebh.2_Missense_Mutation_p.D470G|FUS_uc002ebg.2_Missense_Mutation_p.D266G|FUS_uc002ebi.2_Missense_Mutation_p.D472G|FUS_uc002ebj.2_Missense_Mutation_p.D267G	NM_004960	NP_004951	P35637	FUS_HUMAN	fusion (involved in t(12;16) in malignant	471	Arg/Gly-rich.				cell death|nuclear mRNA splicing, via spliceosome	nucleoplasm	DNA binding|nucleotide binding|protein binding|RNA binding|zinc ion binding		FUS/DDIT3(623)|FUS/ERG(163)|FUS/CREB3L2(158)|FUS/CREB3L1(6)|FUS/ATF1(4)|FUS/FEV(2)	soft_tissue(791)|haematopoietic_and_lymphoid_tissue(153)|bone(12)|breast(2)	958		Renal(780;0.000219)|Breast(268;0.00957)|Hepatocellular(780;0.121)		GBM - Glioblastoma multiforme(240;2.31e-05)|Kidney(780;0.000209)		TACGGGGATGATCGTCGTGGT	0.592		NaN	T	DDIT3|ERG|FEV|ATF1|CREB3L2|CREB3L1	liposarcoma|AML|Ewing sarcoma|angiomatoid fibrous histiocytoma|fibromyxoid sarcoma								0	0	0	0.01441	0	53	101									
NUP93	9688	broad.mit.edu	37	16	56870618	56870618	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr16:56870618G>A	uc002eka.2	+	17	2009	c.1888G>A	c.(1888-1890)GAC>AAC	p.D630N	NUP93_uc002ekb.2_Missense_Mutation_p.D507N|NUP93_uc010vhi.1_Missense_Mutation_p.D507N	NM_014669	NP_055484	Q8N1F7	NUP93_HUMAN	nucleoporin 93kDa	630					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			ovary(1)|lung(1)	2						AAAGCTGTATGACCTTGCCAA	0.428		NaN											0	0	0	0.028581	0	14	20									
SMYD4	114826	broad.mit.edu	37	17	1686727	1686727	+	Missense_Mutation	SNP	C	C	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:1686727C>G	uc002ftm.3	-	9	2232	c.2064G>C	c.(2062-2064)GAG>GAC	p.E688D	SMYD4_uc002ftn.1_Missense_Mutation_p.E543D	NM_052928	NP_443160	Q8IYR2	SMYD4_HUMAN	SET and MYND domain containing 4	688							zinc ion binding			skin(3)|kidney(2)	5						ACAGGAAGCTCTCGGCGTCAC	0.612		NaN											0	0	0	0.00499	0	16	50									
KIF1C	10749	broad.mit.edu	37	17	4910784	4910784	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:4910784G>A	uc002gan.1	+	16	1764	c.1438G>A	c.(1438-1440)GGG>AGG	p.G480R		NM_006612	NP_006603	O43896	KIF1C_HUMAN	kinesin family member 1C	480					microtubule-based movement|retrograde vesicle-mediated transport, Golgi to ER	endoplasmic reticulum|Golgi apparatus|microtubule	ATP binding|microtubule motor activity			breast(2)	2						GGCTGAGATGGGGGTGGCCGT	0.607		NaN											0	0	0	0.01441	0	65	311									
RABEP1	9135	broad.mit.edu	37	17	5257704	5257704	+	Silent	SNP	A	A	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:5257704A>G	uc002gbm.3	+	8	1238	c.1014A>G	c.(1012-1014)GCA>GCG	p.A338A	RABEP1_uc010clc.1_Silent_p.A331A|RABEP1_uc010cld.1_Silent_p.A295A|RABEP1_uc010vsw.1_Silent_p.A295A|RABEP1_uc002gbl.3_Silent_p.A338A	NM_004703	NP_004694	Q15276	RABE1_HUMAN	rabaptin, RAB GTPase binding effector protein 1	338	Potential.				apoptosis|cellular membrane fusion|endocytosis|protein transport	centrosome|early endosome|endocytic vesicle|recycling endosome	growth factor activity|GTPase activator activity|protein homodimerization activity			large_intestine(1)|ovary(1)	2						ACAAAAAAGCAGATGTTGAGG	0.323		NaN											0	0	0	0.006214	0	8	30									
TP53	7157	broad.mit.edu	37	17	7577538	7577538	+	Missense_Mutation	SNP	C	C	G	rs11540652		TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:7577538C>G	uc002gim.2	-	7	937	c.743G>C	c.(742-744)CGG>CCG	p.R248P	TP53_uc002gig.1_Missense_Mutation_p.R248P|TP53_uc002gih.2_Missense_Mutation_p.R248P|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.R116P|TP53_uc010cng.1_Missense_Mutation_p.R116P|TP53_uc002gii.1_Missense_Mutation_p.R116P|TP53_uc010cnh.1_Missense_Mutation_p.R248P|TP53_uc010cni.1_Missense_Mutation_p.R248P|TP53_uc002gij.2_Missense_Mutation_p.R248P|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.R155P|TP53_uc002gio.2_Missense_Mutation_p.R116P	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	248	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|NR -> IP (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(523)|p.R248W(443)|p.R248L(63)|p.R248P(12)|p.R248G(11)|p.R248R(10)|p.0?(7)|p.R155Q(4)|p.N247_R248delNR(2)|p.N247_R248>KW(2)|p.M246_P250delMNRRP(2)|p.R248fs*97(2)|p.R248_P250delRRP(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572	R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIN87_STOMACH)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NIHOVCAR3_OVARY)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(HCC70_BREAST)|R248Q(KYSE150_OESOPHAGUS)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PC14_LUNG)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.01441	0	124	21									
GUCY2D	3000	broad.mit.edu	37	17	7906989	7906989	+	Silent	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:7906989G>A	uc002gjt.2	+	2	698	c.624G>A	c.(622-624)CGG>CGA	p.R208R		NM_000180	NP_000171	Q02846	GUC2D_HUMAN	guanylate cyclase 2D, membrane (retina-specific)	208	Extracellular (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway|visual perception	integral to plasma membrane|nuclear outer membrane	ATP binding|GTP binding|guanylate cyclase activity|protein kinase activity|receptor activity			skin(1)	1		Prostate(122;0.157)				TCAGGGCCCGGGGCCTGCCTG	0.711		NaN											0	0	0	0.010729	0	10	52									
MYH4	4622	broad.mit.edu	37	17	10364372	10364372	+	Splice_Site	SNP	C	C	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:10364372C>G	uc002gmn.2	-	12	1120	c.1009_splice	c.e12-1	p.S337_splice	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle						muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						CCACAGCACTCTGTCAAAAGA	0.463		NaN											0	0	0	0.009535	0	22	103									
MYH1	4619	broad.mit.edu	37	17	10409366	10409366	+	Silent	SNP	A	A	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:10409366A>G	uc002gmo.2	-	18	2113	c.2019T>C	c.(2017-2019)TTT>TTC	p.F673F	uc002gml.1_Intron	NM_005963	NP_005954	P12882	MYH1_HUMAN	myosin, heavy chain 1, skeletal muscle, adult	673	Myosin head-like.|Actin-binding (By similarity).					muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|motor activity			ovary(10)|skin(6)|breast(3)|upper_aerodigestive_tract(1)|kidney(1)	21						TGCACCGCACAAAGTGGGGGT	0.423		NaN											0	0	0	0.01441	0	35	166									
KCNJ12	3768	broad.mit.edu	37	17	21319580	21319580	+	Missense_Mutation	SNP	C	C	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:21319580C>G	uc002gyv.1	+	3	1631	c.926C>G	c.(925-927)ACC>AGC	p.T309S		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	309	Cytoplasmic (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	ACAGCCATGACCACCCAGGCC	0.607		NaN								Prostate(3;0.18)			0	0	0	0.027356	0	22	268									
HNF1B	6928	broad.mit.edu	37	17	36070615	36070615	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:36070615G>A	uc002hok.3	-	5	1323	c.1102C>T	c.(1102-1104)CAC>TAC	p.H368Y	HNF1B_uc010wdi.1_Missense_Mutation_p.H342Y	NM_000458	NP_000449	P35680	HNF1B_HUMAN	hepatocyte nuclear factor 1-beta isoform 1	368					endocrine pancreas development|genitalia development|kidney development|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric nephron tubule development|regulation of pronephros size	nucleus	DNA binding|protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)	3		Breast(25;0.00765)|Ovarian(249;0.15)	STAD - Stomach adenocarcinoma(1;0.0142)			TTGCCATGGTGACTGATTGTT	0.537		NaN							Hereditary_Prostate_Cancer				0	0	0	0.016522	0	21	46									
MED1	5469	broad.mit.edu	37	17	37563898	37563898	+	Missense_Mutation	SNP	G	G	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:37563898G>C	uc002hrv.3	-	17	4788	c.4576C>G	c.(4576-4578)CAT>GAT	p.H1526D	MED1_uc010wee.1_Missense_Mutation_p.H1354D|MED1_uc002hru.2_Intron	NM_004774	NP_004765	Q15648	MED1_HUMAN	mediator complex subunit 1	1526	Lys-rich.				androgen biosynthetic process|androgen receptor signaling pathway|cellular lipid metabolic process|fat cell differentiation|positive regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription initiation from RNA polymerase II promoter	mediator complex	DNA binding|estrogen receptor binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|peroxisome proliferator activated receptor binding|receptor activity|retinoic acid receptor binding|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			lung(2)|ovary(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	8		Ovarian(249;1.78e-06)|Lung SC(565;0.0262)	Lung(15;0.0178)|LUAD - Lung adenocarcinoma(14;0.146)	UCEC - Uterine corpus endometrioid carcinoma (308;6.64e-05)|BRCA - Breast invasive adenocarcinoma(366;0.00136)|READ - Rectum adenocarcinoma(1115;0.0649)		TTGATGCTATGAGATTTTTTC	0.318		NaN								HNSCC(31;0.082)			0	0	0	0.016522	0	21	83									
C17orf37	84299	broad.mit.edu	37	17	37885818	37885818	+	Missense_Mutation	SNP	A	A	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:37885818A>G	uc002hsq.2	-	4	345	c.305T>C	c.(304-306)CTA>CCA	p.L102P		NM_032339	NP_115715	Q9BRT3	CQ037_HUMAN	hypothetical protein LOC84299	102					cell redox homeostasis	cytosol|membrane	selenium binding				0	all_cancers(6;1.06e-93)|all_epithelial(6;2.33e-113)|Breast(7;9.37e-100)|Lung NSC(9;9.76e-10)|all_lung(9;5.34e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|Epithelial(3;3.72e-63)|all cancers(3;1.87e-56)|BRCA - Breast invasive adenocarcinoma(8;6.8e-45)|STAD - Stomach adenocarcinoma(3;1.43e-12)|Colorectal(5;6.23e-08)|COAD - Colon adenocarcinoma(5;8.58e-06)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|OV - Ovarian serous cystadenocarcinoma(8;0.0917)|LUSC - Lung squamous cell carcinoma(15;0.171)			GATCTTTTCTAGGGTTTCTCC	0.542		NaN											0	0	0	0.009718	0	40	190									
PLEKHH3	79990	broad.mit.edu	37	17	40823016	40823016	+	Missense_Mutation	SNP	C	C	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:40823016C>G	uc002iau.2	-	9	1884	c.1417G>C	c.(1417-1419)GAG>CAG	p.E473Q	PLEKHH3_uc010cyl.1_Intron|PLEKHH3_uc002iat.1_Intron|PLEKHH3_uc002iav.2_RNA|PLEKHH3_uc010cym.1_Intron|PLEKHH3_uc002iaw.2_Intron	NM_024927	NP_079203	Q7Z736	PKHH3_HUMAN	pleckstrin homology domain containing, family H	473	FERM.				signal transduction	cytoskeleton				large_intestine(1)|ovary(1)	2		Breast(137;0.00116)		BRCA - Breast invasive adenocarcinoma(366;0.14)		ATTTACTTCTCAAACCTGGTG	0.637		NaN											0	0	0	0.01441	0	69	252									
DCAF7	10238	broad.mit.edu	37	17	61628110	61628110	+	Missense_Mutation	SNP	G	G	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:61628110G>C	uc002jbc.2	+	1	289	c.72G>C	c.(70-72)TGG>TGC	p.W24C	DCAF7_uc002jbb.2_RNA|DCAF7_uc010wpn.1_Missense_Mutation_p.W24C	NM_005828	NP_005819	P61962	DCAF7_HUMAN	WD-repeat protein	24					multicellular organismal development	CUL4 RING ubiquitin ligase complex|cytoplasm|nucleus	protein binding			ovary(1)	1						CGATGAACTGGAGTGTGCGGC	0.642		NaN											0	0	0	0.027356	0	28	97									
ABCA8	10351	broad.mit.edu	37	17	66913593	66913593	+	Splice_Site	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:66913593C>T	uc002jhp.2	-	15	2107	c.1928_splice	c.e15-1	p.D643_splice	ABCA8_uc002jhq.2_Splice_Site_p.D683_splice|ABCA8_uc010wqq.1_Splice_Site_p.D683_splice|ABCA8_uc010wqr.1_Splice_Site_p.D622_splice|ABCA8_uc002jhr.2_Splice_Site_p.D683_splice	NM_007168	NP_009099	O94911	ABCA8_HUMAN	ATP-binding cassette, sub-family A member 8							integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3	Breast(10;4.56e-13)					ACTTTCCTGTCTGAAAAAGAA	0.373		NaN											0	0	0	0.007413	0	19	66									
PYCR1	5831	broad.mit.edu	37	17	79892301	79892301	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:79892301G>A	uc002kcr.1	-	6	976	c.698C>T	c.(697-699)TCT>TTT	p.S233F	PYCR1_uc002kcq.1_Intron|PYCR1_uc002kcp.2_Missense_Mutation_p.S233F|PYCR1_uc002kcs.1_Intron|PYCR1_uc010wvd.1_Missense_Mutation_p.S260F|PYCR1_uc002kct.1_Missense_Mutation_p.S233F|PYCR1_uc002kcu.1_Missense_Mutation_p.S202F|PYCR1_uc010wve.1_Missense_Mutation_p.S154F	NM_006907	NP_008838	P32322	P5CR1_HUMAN	pyrroline-5-carboxylate reductase 1 isoform 1	233					cellular response to oxidative stress|proline biosynthetic process	mitochondrial matrix	binding|pyrroline-5-carboxylate reductase activity				0	all_neural(118;0.0878)|Ovarian(332;0.12)		BRCA - Breast invasive adenocarcinoma(99;0.0165)|OV - Ovarian serous cystadenocarcinoma(97;0.0382)		L-Proline(DB00172)|NADH(DB00157)	CCCACCAGGAGAGCTGACGTT	0.637		NaN											0	0	0	0.014758	0	5	40									
DUS1L	64118	broad.mit.edu	37	17	80017896	80017896	+	Missense_Mutation	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:80017896C>T	uc002kdq.2	-	10	1515	c.1096G>A	c.(1096-1098)GAG>AAG	p.E366K	DUS1L_uc002kdp.2_Missense_Mutation_p.E235K|DUS1L_uc002kdr.2_Missense_Mutation_p.E366K|DUS1L_uc002kds.2_RNA|DUS1L_uc002kdt.2_RNA	NM_022156	NP_071439	Q6P1R4	DUS1L_HUMAN	PP3111 protein	366					tRNA processing		flavin adenine dinucleotide binding|tRNA dihydrouridine synthase activity			skin(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			GACAGGACCTCCGTGCCACCC	0.652		NaN											0	0	0	0.021523	0	23	102									
USP14	9097	broad.mit.edu	37	18	179002	179002	+	Missense_Mutation	SNP	G	G	A	rs141269921	by1000genomes	TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr18:179002G>A	uc002kkf.1	+	4	481	c.265G>A	c.(265-267)GTA>ATA	p.V89I	USP14_uc002kkg.1_Intron|USP14_uc010wyr.1_Missense_Mutation_p.V78I	NM_005151	NP_005142	P54578	UBP14_HUMAN	ubiquitin specific protease 14 isoform a	89					regulation of chemotaxis|regulation of proteasomal protein catabolic process|ubiquitin-dependent protein catabolic process	cell surface|cytoplasmic membrane-bounded vesicle|plasma membrane|proteasome complex	cysteine-type endopeptidase activity|endopeptidase inhibitor activity|proteasome binding|tRNA guanylyltransferase activity|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			ovary(2)	2		all_cancers(4;0.0896)|Myeloproliferative disorder(11;0.0412)				AACTGTCTTCGTAGAAGACAT	0.373		NaN											0	0	0	0.010818	0	25	22									
L3MBTL4	91133	broad.mit.edu	37	18	6301906	6301906	+	Missense_Mutation	SNP	A	A	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr18:6301906A>C	uc002kmz.3	-	4	283	c.123T>G	c.(121-123)AGT>AGG	p.S41R	L3MBTL4_uc010dkt.2_Missense_Mutation_p.S41R	NM_173464	NP_775735	Q8NA19	LMBL4_HUMAN	l(3)mbt-like 4	41					chromatin modification	nucleus	sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(2)|pancreas(1)	3		Colorectal(10;0.0249)				AATTACCGTGACTCAAAGGGG	0.338		NaN											0	0	0	0.012213	0	25	118									
ANKRD12	23253	broad.mit.edu	37	18	9281059	9281059	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr18:9281059G>A	uc002knv.2	+	13	6381	c.6124G>A	c.(6124-6126)GAA>AAA	p.E2042K	ANKRD12_uc002knw.2_Missense_Mutation_p.E2019K|ANKRD12_uc002knx.2_Missense_Mutation_p.E2019K	NM_015208	NP_056023	Q6UB98	ANR12_HUMAN	ankyrin repeat domain 12 isoform 1	2042						nucleus				ovary(2)|central_nervous_system(1)	3						CAGCATTTACGAAATCCAGGA	0.418		NaN											0	0	0	0.01441	0	48	79									
CELF4	56853	broad.mit.edu	37	18	34901838	34901838	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr18:34901838G>A	uc002lae.2	-	3	772	c.376C>T	c.(376-378)CGG>TGG	p.R126W	CELF4_uc010dnd.1_Missense_Mutation_p.R126W|CELF4_uc002lag.2_Missense_Mutation_p.R126W|CELF4_uc002laf.2_Missense_Mutation_p.R122W|CELF4_uc002lai.2_Missense_Mutation_p.R122W	NM_020180	NP_064565	Q9BZC1	CELF4_HUMAN	bruno-like 4, RNA binding protein isoform 1	126	RRM 1.|Sufficient for RNA-binding and MSE- dependent splicing activity.				embryo development|germ cell development|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	BRE binding|nucleotide binding|translation repressor activity, nucleic acid binding			ovary(2)	2						TGGATCGGCCGGTTCATCTGC	0.597		NaN									OREG0024927	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	41	67									
DSEL	92126	broad.mit.edu	37	18	65180301	65180301	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr18:65180301C>T	uc002lke.1	-	2	2799	c.1575G>A	c.(1573-1575)TGG>TGA	p.W525*		NM_032160	NP_115536	Q8IZU8	DSEL_HUMAN	dermatan sulfate epimerase-like	515						integral to membrane	isomerase activity|sulfotransferase activity			ovary(3)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	6		Esophageal squamous(42;0.129)				GTTGACCTTCCCAGGGCTTAT	0.488		NaN											0	0	0	0.019004	0	33	75									
CSNK1G2	1455	broad.mit.edu	37	19	1978971	1978971	+	Missense_Mutation	SNP	C	C	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:1978971C>G	uc002lul.3	+	7	1084	c.561C>G	c.(559-561)ATC>ATG	p.I187M	CSNK1G2_uc010dsu.2_Missense_Mutation_p.I139M	NM_001319	NP_001310	P78368	KC1G2_HUMAN	casein kinase 1, gamma 2	187	Protein kinase.				sphingolipid metabolic process|Wnt receptor signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity			stomach(1)	1		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TCCACATCATCGACTTCGGGC	0.617		NaN											0	0	0	0.027894	0	35	82									
AES	166	broad.mit.edu	37	19	3053861	3053861	+	Missense_Mutation	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:3053861C>T	uc002lwy.1	-	7	723	c.550G>A	c.(550-552)GAT>AAT	p.D184N	AES_uc002lwx.1_3'UTR|AES_uc002lwz.1_Missense_Mutation_p.D183N|AES_uc002lxa.1_Missense_Mutation_p.D128N|AES_uc002lxb.1_Missense_Mutation_p.D251N|AES_uc002lxc.2_Missense_Mutation_p.R277Q	NM_001130	NP_001121	Q08117	AES_HUMAN	amino-terminal enhancer of split isoform b	184	CCN domain.				negative regulation of canonical Wnt receptor signaling pathway|negative regulation of protein binding|negative regulation of response to cytokine stimulus|negative regulation of transcription from RNA polymerase II promoter|organ morphogenesis|response to interleukin-1|transcription, DNA-dependent|Wnt receptor signaling pathway	nucleus	protein binding|transcription corepressor activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGTCACCATCGTGCCCGTTC	0.682		NaN											0	0	0	0.024334	0	19	83									
PLIN3	10226	broad.mit.edu	37	19	4852049	4852049	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:4852049G>A	uc002mbj.2	-	5	790	c.613C>T	c.(613-615)CCC>TCC	p.P205S	PLIN3_uc002mbk.2_Missense_Mutation_p.P193S|PLIN3_uc002mbl.3_Missense_Mutation_p.P205S	NM_005817	NP_005808	O60664	PLIN3_HUMAN	mannose 6 phosphate receptor binding protein 1	205					vesicle-mediated transport	endosome membrane|Golgi apparatus|lipid particle	protein binding				0					Galsulfase(DB01279)|Idursulfase(DB01271)	TCCGTAAGGGGCAGGTGGTTG	0.682		NaN									OREG0025175	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.016522	0	18	81									
GPR108	56927	broad.mit.edu	37	19	6731901	6731901	+	Splice_Site	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:6731901C>T	uc002mfp.2	-	14	1346	c.1300_splice	c.e14+1	p.V434_splice	GPR108_uc010duv.2_Intron|GPR108_uc002mfn.2_Splice_Site_p.V105_splice|GPR108_uc002mfo.3_Splice_Site_p.V192_splice|GPR108_uc010duw.2_Splice_Site	NM_001080452	NP_001073921	Q9NPR9	GP108_HUMAN	G protein-coupled receptor 108 isoform 1							integral to membrane					0						CAGGGCCTCACCCTTCCCGTC	0.662		NaN											0	0	0	0.020292	0	13	1									
CLEC4M	10332	broad.mit.edu	37	19	7833781	7833781	+	Silent	SNP	G	G	A	rs144974332		TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:7833781G>A	uc002mih.2	+	8	1156	c.1038G>A	c.(1036-1038)GCG>GCA	p.A346A	CLEC4M_uc010xjw.1_Silent_p.A302A|CLEC4M_uc010dvt.2_Silent_p.A323A|CLEC4M_uc010dvs.2_Silent_p.A345A|CLEC4M_uc010xjx.1_Silent_p.A318A|CLEC4M_uc002mhz.2_3'UTR|CLEC4M_uc002mic.2_3'UTR|CLEC4M_uc002mia.2_Silent_p.A233A	NM_001144910	NP_001138382	Q9H2X3	CLC4M_HUMAN	C-type lectin domain family 4, member M isoform	369	Extracellular (Probable).|C-type lectin.				cell-cell recognition|endocytosis|innate immune response|intracellular signal transduction|intracellular virion transport|leukocyte cell-cell adhesion|peptide antigen transport|viral genome replication|virion attachment to host cell surface receptor	cytoplasm|extracellular region|integral to plasma membrane	ICAM-3 receptor activity|mannose binding|metal ion binding|peptide antigen binding|virion binding			pancreas(1)	1						AAGACTGTGCGGAATTTAGTG	0.512		NaN											0	0	0	0.00499	0	14	148									
EVI5L	115704	broad.mit.edu	37	19	7918186	7918186	+	Missense_Mutation	SNP	G	G	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:7918186G>C	uc002min.2	+	10	1267	c.1113G>C	c.(1111-1113)AAG>AAC	p.K371N	EVI5L_uc010xjz.1_Missense_Mutation_p.K371N|EVI5L_uc002mio.1_Missense_Mutation_p.K102N	NM_145245	NP_660288	Q96CN4	EVI5L_HUMAN	ecotropic viral integration site 5-like isoform	371	Potential.					intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1						CAGCCATGAAGAGCAAGGAGA	0.627		NaN									OREG0025211	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00308	0	7	15									
MUC16	94025	broad.mit.edu	37	19	9017366	9017366	+	Missense_Mutation	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:9017366C>T	uc002mkp.2	-	26	38162	c.37958G>A	c.(37957-37959)AGG>AAG	p.R12653K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	12655	SEA 4.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						GAGACTGTTCCTGTCCAGGGT	0.567		NaN											0	0	0	0.01441	0	259	52									
MUC16	94025	broad.mit.edu	37	19	9072253	9072253	+	Missense_Mutation	SNP	A	A	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:9072253A>C	uc002mkp.2	-	3	15397	c.15193T>G	c.(15193-15195)TCC>GCC	p.S5065A		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5067	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding	p.S5065Y(1)		lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ATAGGAGAGGAGAGCTTATCC	0.478		NaN											0	0	0	0.01441	0	65	18									
OR7G2	390882	broad.mit.edu	37	19	9213857	9213857	+	Silent	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:9213857C>T	uc010xkk.1	-	1	126	c.126G>A	c.(124-126)CCG>CCA	p.P42P		NM_001005193	NP_001005193	Q8NG99	OR7G2_HUMAN	olfactory receptor, family 7, subfamily G,	21	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GCTGCAGTTCCGGATCCTCTA	0.468		NaN											0	0	0	0.017118	0	30	94									
ZNF426	79088	broad.mit.edu	37	19	9639507	9639507	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:9639507G>A	uc002mlq.2	-	8	1478	c.1214C>T	c.(1213-1215)TCA>TTA	p.S405L	ZNF426_uc010dws.2_Missense_Mutation_p.S367L	NM_024106	NP_077011	Q9BUY5	ZN426_HUMAN	zinc finger protein 426	405	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ACTAAGATTTGAGGAAACTGC	0.408		NaN											0	0	0	0.004482	0	8	27									
ZNF844	284391	broad.mit.edu	37	19	12187502	12187502	+	Missense_Mutation	SNP	A	A	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:12187502A>G	uc002mtb.2	+	4	1710	c.1567A>G	c.(1567-1569)AAA>GAA	p.K523E	ZNF844_uc010dym.1_Missense_Mutation_p.K366E	NM_001136501	NP_001129973	Q08AG5	ZN844_HUMAN	zinc finger protein 844	523					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CAAATGCATGAAAGGACTCAC	0.413		NaN											0	0	0	0.014758	0	4	44									
FCHO1	23149	broad.mit.edu	37	19	17892531	17892531	+	Silent	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:17892531G>A	uc010ebb.2	+	22	2028	c.1839G>A	c.(1837-1839)CGG>CGA	p.R613R	FCHO1_uc002nhg.3_Silent_p.R613R|FCHO1_uc002nhh.2_Silent_p.R613R|FCHO1_uc010xpw.1_Silent_p.R563R|FCHO1_uc002nhi.2_Silent_p.R69R|FCHO1_uc002nhj.2_5'UTR	NM_001161358	NP_001154830	O14526	FCHO1_HUMAN	FCH domain only 1 isoform b	613										breast(1)	1						GAGTCTCCCGGGGTCCGAGCC	0.627		NaN											0	0	0	0.01441	0	214	45									
KIAA1683	80726	broad.mit.edu	37	19	18378333	18378333	+	Missense_Mutation	SNP	C	C	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:18378333C>G	uc002nin.2	-	3	233	c.17G>C	c.(16-18)AGA>ACA	p.R6T	KIAA1683_uc010ebn.2_Missense_Mutation_p.R6T|KIAA1683_uc010xqe.1_5'UTR	NM_025249	NP_079525	Q9H0B3	K1683_HUMAN	KIAA1683 isoform b	6						mitochondrion				ovary(2)	2						CAGGTCAGCTCTGCCTGTGGG	0.652		NaN											0	0	0	0.01441	0	88	177									
ZNF626	199777	broad.mit.edu	37	19	20807986	20807986	+	Missense_Mutation	SNP	C	C	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:20807986C>G	uc002npb.1	-	4	847	c.697G>C	c.(697-699)GAA>CAA	p.E233Q	ZNF626_uc002npc.1_Missense_Mutation_p.E157Q	NM_001076675	NP_001070143	Q68DY1	ZN626_HUMAN	zinc finger protein 626 isoform 1	233	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						TTGCCACATTCTTCACATTTG	0.398		NaN											0	0	0	0.020292	0	11	41									
ZNF536	9745	broad.mit.edu	37	19	31039640	31039640	+	Silent	SNP	A	A	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:31039640A>G	uc002nsu.1	+	4	3252	c.3114A>G	c.(3112-3114)ACA>ACG	p.T1038T	ZNF536_uc010edd.1_Silent_p.T1038T	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1038					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					TCGGGGTCACAGTCAACTGCA	0.537		NaN											0	0	0	0.015359	0	32	104									
PRX	57716	broad.mit.edu	37	19	40909668	40909668	+	Silent	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:40909668G>A	uc002onr.2	-	5	398	c.129C>T	c.(127-129)TTC>TTT	p.F43F	PRX_uc002onq.2_5'UTR|PRX_uc002ons.2_Silent_p.F43F	NM_181882	NP_870998	Q9BXM0	PRAX_HUMAN	periaxin isoform 2	43	PDZ.				axon ensheathment	cytoplasm|nucleus|plasma membrane	protein binding			ovary(2)	2			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GCTCCCGAACGAAGATTCCCT	0.701		NaN											0	0	0	0.021553	0	5	15									
PNMAL2	57469	broad.mit.edu	37	19	46997598	46997598	+	Silent	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:46997598G>A	uc002pes.2	-	1	1572	c.1125C>T	c.(1123-1125)GTC>GTT	p.V375V	uc002peu.1_5'Flank	NM_020709	NP_065760	Q9ULN7	PNML2_HUMAN	PNMA-like 2	375										central_nervous_system(1)	1		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.00233)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		TGACGGACAAGACCTGTCGGA	0.642		NaN											0	0	0	0.004482	0	8	41									
PTGIR	5739	broad.mit.edu	37	19	47124612	47124612	+	Silent	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:47124612G>A	uc002pex.2	-	3	1199	c.1086C>T	c.(1084-1086)CCC>CCT	p.P362P		NM_000960	NP_000951	P43119	PI2R_HUMAN	prostaglandin I2 (prostacyclin) receptor (IP)	362	Cytoplasmic (Potential).				cell-cell signaling|G-protein signaling, coupled to cyclic nucleotide second messenger|platelet activation	integral to plasma membrane	G-protein coupled receptor activity|guanyl-nucleotide exchange factor activity				0		Ovarian(192;0.0129)|all_neural(266;0.0459)|Breast(70;0.212)		OV - Ovarian serous cystadenocarcinoma(262;0.000327)|all cancers(93;0.000641)|Epithelial(262;0.0174)|GBM - Glioblastoma multiforme(486;0.0331)	Dinoprost Tromethamine(DB01160)|Dinoprostone(DB00917)|Epoprostenol(DB01240)|Iloprost(DB01088)|Misoprostol(DB00929)	ACTGCTGTGTGGGAGGCAAGG	0.657		NaN											0	0	0	0.01441	0	53	15									
GRLF1	2909	broad.mit.edu	37	19	47424411	47424411	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:47424411G>A	uc010ekv.2	+	1	2479	c.2479G>A	c.(2479-2481)GGA>AGA	p.G827R		NM_004491	NP_004482	Q9NRY4	RHG35_HUMAN	glucocorticoid receptor DNA binding factor 1	827					axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity			central_nervous_system(1)	1		all_cancers(25;1.51e-09)|all_epithelial(76;1.87e-07)|all_lung(116;7.86e-06)|Lung NSC(112;2.31e-05)|Ovarian(192;0.0129)|all_neural(266;0.026)|Breast(70;0.077)		all cancers(93;2.03e-05)|OV - Ovarian serous cystadenocarcinoma(262;2.57e-05)|Epithelial(262;0.00135)|GBM - Glioblastoma multiforme(486;0.0289)		ACTACCAATCGGACTGCACAA	0.408		NaN											0	0	0	0.024334	0	23	33									
DBP	1628	broad.mit.edu	37	19	49136903	49136903	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:49136903G>A	uc002pjx.3	-	3	948	c.560C>T	c.(559-561)TCT>TTT	p.S187F	DBP_uc002pjy.2_3'UTR|DBP_uc010elz.1_Missense_Mutation_p.S187F	NM_001352	NP_001343	Q10586	DBP_HUMAN	D site of albumin promoter (albumin D-box)	187					regulation of transcription from RNA polymerase II promoter|rhythmic process	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_lung(116;0.000125)|Lung NSC(112;0.000202)|all_epithelial(76;0.000283)|all_neural(266;0.0506)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;9.98e-05)|all cancers(93;0.000112)|GBM - Glioblastoma multiforme(486;0.00615)|Epithelial(262;0.0155)		TGTGTCCCGAGAGGTCAGGCC	0.542		NaN											0	0	0	0.009535	0	29	81									
GPR32	2854	broad.mit.edu	37	19	51274466	51274466	+	Missense_Mutation	SNP	G	G	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:51274466G>C	uc010ycf.1	+	1	609	c.609G>C	c.(607-609)CAG>CAC	p.Q203H		NM_001506	NP_001497	O75388	GPR32_HUMAN	G protein-coupled receptor 32	203	Extracellular (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		AGACTGCCCAGATTTGGATTG	0.552		NaN											0	0	0	0.01441	0	57	13									
UBE2M	9040	broad.mit.edu	37	19	59069644	59069644	+	Silent	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:59069644C>T	uc002qtl.3	-	1	700	c.105G>A	c.(103-105)CAG>CAA	p.Q35Q	LOC100131691_uc002qtm.2_5'Flank	NM_003969	NP_003960	P61081	UBC12_HUMAN	ubiquitin-conjugating enzyme E2M	35	Interaction with UBA3.			Q->A: Strongly impairs thioester intermediate formation.	protein neddylation		ATP binding|NEDD8 ligase activity|protein binding|ribosomal S6-glutamic acid ligase activity|ubiquitin-protein ligase activity			ovary(1)|pancreas(1)	2		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0434)|all cancers(4;1.39e-13)|Epithelial(4;1.01e-10)|OV - Ovarian serous cystadenocarcinoma(4;2.34e-09)|GBM - Glioblastoma multiforme(193;0.0102)|Lung(386;0.179)		CCCTACCCTTCTGGATCCGCA	0.647		NaN											0	0	0	0.008871	0	17	58									
ABCG8	64241	broad.mit.edu	37	2	44101118	44101118	+	Silent	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr2:44101118C>T	uc002rtq.2	+	9	1494	c.1404C>T	c.(1402-1404)ATC>ATT	p.I468I	ABCG8_uc010yoa.1_Silent_p.I467I	NM_022437	NP_071882	Q9H221	ABCG8_HUMAN	ATP-binding cassette sub-family G member 8	468	Helical; Name=2; (Potential).|ABC transmembrane type-2.				cholesterol efflux|cholesterol homeostasis|excretion|lipid metabolic process|negative regulation of intestinal cholesterol absorption|negative regulation of intestinal phytosterol absorption	apical plasma membrane|integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity			skin(3)|ovary(1)	4		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TGGATGTCATCTCCAAATGTG	0.542		NaN											0	0	0	0.01441	0	62	97									
SLC4A5	57835	broad.mit.edu	37	2	74462335	74462335	+	Missense_Mutation	SNP	C	C	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr2:74462335C>A	uc002sko.1	-	17	2328	c.2326G>T	c.(2326-2328)GCC>TCC	p.A776S	SLC4A5_uc002skl.2_RNA|SLC4A5_uc002skn.2_Missense_Mutation_p.A776S|SLC4A5_uc010ffc.1_Missense_Mutation_p.A776S|SLC4A5_uc002skp.1_Intron|SLC4A5_uc002sks.1_Intron	NM_021196	NP_067019	Q9BY07	S4A5_HUMAN	sodium bicarbonate transporter 4 isoform a	776	Extracellular (Potential).					apical plasma membrane|integral to membrane	inorganic anion exchanger activity|sodium:bicarbonate symporter activity			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	9						GCCACCAGGGCCCGGACCTGC	0.532		NaN											1	0	1.96292e-10	0.010504	2.08011e-10	20	10									
FABP1	2168	broad.mit.edu	37	2	88425824	88425824	+	Silent	SNP	C	C	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr2:88425824C>A	uc002sst.1	-	2	153	c.111G>T	c.(109-111)GGG>GGT	p.G37G	FABP1_uc002ssu.2_Silent_p.G37G	NM_001443	NP_001434	P07148	FABPL_HUMAN	fatty acid binding protein 1, liver	37					organ morphogenesis						0						TTTCCGACACCCCCTTGATAT	0.532		NaN											1	0	2.09629e-50	0.01441	2.36249e-50	104	197									
DPP10	57628	broad.mit.edu	37	2	116066873	116066873	+	Missense_Mutation	SNP	T	T	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr2:116066873T>A	uc002tla.1	+	2	576	c.119T>A	c.(118-120)CTG>CAG	p.L40Q	DPP10_uc002tlb.1_5'UTR|DPP10_uc002tlc.1_Missense_Mutation_p.L36Q|DPP10_uc002tle.2_Missense_Mutation_p.L44Q|DPP10_uc002tlf.1_Missense_Mutation_p.L33Q	NM_020868	NP_065919	Q8N608	DPP10_HUMAN	dipeptidyl peptidase 10 isoform long	40	Mediates effects on KCND2.|Helical; Signal-anchor for type II membrane protein; (Potential).				proteolysis	integral to membrane|membrane fraction	serine-type peptidase activity			ovary(5)|large_intestine(2)|skin(2)|breast(1)	10						ATTGCTCTGCTGGTGATTTTA	0.408		NaN											0	0	0	0.021022	0	28	28									
TTN	7273	broad.mit.edu	37	2	179397839	179397839	+	Missense_Mutation	SNP	C	C	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr2:179397839C>G	uc010zfg.1	-	307	96023	c.95799G>C	c.(95797-95799)GAG>GAC	p.E31933D	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.E25628D|TTN_uc010zfi.1_Missense_Mutation_p.E25561D|TTN_uc010zfj.1_Missense_Mutation_p.E25436D	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	32860							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTCTCAGAGCCTCTTTAGCTA	0.428		NaN											0	0	0	0.007835	0	37	60									
TNS1	7145	broad.mit.edu	37	2	218699859	218699859	+	Missense_Mutation	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr2:218699859C>T	uc002vgt.2	-	19	3258	c.2860G>A	c.(2860-2862)GAG>AAG	p.E954K	TNS1_uc002vgr.2_Missense_Mutation_p.E954K|TNS1_uc002vgs.2_Missense_Mutation_p.E954K|TNS1_uc010zjv.1_Missense_Mutation_p.E954K	NM_022648	NP_072174	Q9HBL0	TENS1_HUMAN	tensin	954						cytoplasm|cytoskeleton|focal adhesion	actin binding			ovary(3)|breast(1)	4		Renal(207;0.0483)|Lung NSC(271;0.213)		Epithelial(149;4.43e-06)|all cancers(144;0.000653)|LUSC - Lung squamous cell carcinoma(224;0.0091)|Lung(261;0.013)		TCCATCTCCTCGAAGGCCTCC	0.572		NaN											0	0	0	0.013114	0	38	13									
ALPP	250	broad.mit.edu	37	2	233245162	233245162	+	Silent	SNP	C	C	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr2:233245162C>G	uc002vsq.2	+	7	990	c.825C>G	c.(823-825)CTC>CTG	p.L275L	ALPP_uc002vsr.2_5'Flank	NM_001632	NP_001623	P05187	PPB1_HUMAN	placental alkaline phosphatase preproprotein	275						anchored to membrane|cell surface|integral to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			ovary(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)		GCACTGAGCTCATGCAGGCTT	0.647		NaN											0	0	0	0.01441	0	65	117									
PANK2	80025	broad.mit.edu	37	20	3870313	3870313	+	Missense_Mutation	SNP	C	C	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr20:3870313C>G	uc002wkc.2	+	1	572	c.566C>G	c.(565-567)TCT>TGT	p.S189C	uc002wjz.1_5'Flank|uc002wka.1_5'Flank|PANK2_uc002wkb.2_Intron|PANK2_uc010gbd.1_RNA|PANK2_uc002wkd.2_RNA|PANK2_uc002wke.2_5'Flank|PANK2_uc002wkf.2_5'Flank	NM_153638	NP_705902	Q9BZ23	PANK2_HUMAN	pantothenate kinase 2 isoform 1 preproprotein	189					cell death|coenzyme A biosynthetic process|pantothenate metabolic process	mitochondrial intermembrane space|nucleus	ATP binding|pantothenate kinase activity|protein binding				0						CGACTGGGCTCTTACAGCGGC	0.751		NaN											0	0	0	0.00308	0	6	38									
C20orf26	26074	broad.mit.edu	37	20	20051628	20051628	+	Missense_Mutation	SNP	G	G	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr20:20051628G>T	uc002wru.2	+	3	350	c.274G>T	c.(274-276)GAC>TAC	p.D92Y	C20orf26_uc010gcw.1_Missense_Mutation_p.D46Y|C20orf26_uc010zse.1_Missense_Mutation_p.D92Y|C20orf26_uc010zsf.1_Missense_Mutation_p.D92Y	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	92										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		CCGGGAGCTCGACAGTGACAT	0.498		NaN											1	0	6.05902e-23	0.017118	6.64387e-23	28	136									
KCNS1	3787	broad.mit.edu	37	20	43727083	43727083	+	Silent	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr20:43727083G>A	uc002xnc.2	-	4	727	c.330C>T	c.(328-330)TTC>TTT	p.F110F	KCNS1_uc002xnd.2_Silent_p.F110F	NM_002251	NP_002242	Q96KK3	KCNS1_HUMAN	potassium voltage-gated channel	110	Cytoplasmic (Potential).					voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity|protein binding				0		Myeloproliferative disorder(115;0.0122)				GGCTCAGGAAGAAGCCCGGGT	0.692		NaN											0	0	0	0.024245	0	11	11									
ZNF335	63925	broad.mit.edu	37	20	44596540	44596540	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr20:44596540G>A	uc002xqw.2	-	5	770	c.647C>T	c.(646-648)CCG>CTG	p.P216L	ZNF335_uc010zxk.1_Missense_Mutation_p.P61L|ZNF335_uc002xqx.1_Missense_Mutation_p.P184L|ZNF335_uc002xqy.2_Missense_Mutation_p.P61L	NM_022095	NP_071378	Q9H4Z2	ZN335_HUMAN	zinc finger protein 335	216					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(3)|ovary(1)	4		Myeloproliferative disorder(115;0.0122)				CAGCTGCACCGGGGAGCTGGG	0.647		NaN											0	0	0	0.021022	0	36	121									
PSMA7	5688	broad.mit.edu	37	20	60712444	60712444	+	Silent	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr20:60712444G>A	uc002ybx.1	-	6	745	c.630C>T	c.(628-630)GTC>GTT	p.V210V	PSMA7_uc002yby.1_RNA	NM_002792	NP_002783	O14818	PSA7_HUMAN	proteasome alpha 7 subunit	210					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	identical protein binding|threonine-type endopeptidase activity				0	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.28e-07)			CTCGCCTCATGACAGCAAGTT	0.463		NaN									OREG0026105	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	125	75									
TPTE	7179	broad.mit.edu	37	21	10934109	10934109	+	Missense_Mutation	SNP	A	A	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr21:10934109A>C	uc002yip.1	-	16	1236	c.868T>G	c.(868-870)TAC>GAC	p.Y290D	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.Y272D|TPTE_uc002yir.1_Missense_Mutation_p.Y252D|TPTE_uc010gkv.1_Missense_Mutation_p.Y152D	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	290	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		TTAGGATCGTAAGCTCTTTCA	0.303		NaN											0	0	0	0.024245	0	14	74									
TMPRSS2	7113	broad.mit.edu	37	21	42860419	42860419	+	Missense_Mutation	SNP	G	G	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr21:42860419G>C	uc002yzj.2	-	5	481	c.347C>G	c.(346-348)TCT>TGT	p.S116C	TMPRSS2_uc010gor.2_Missense_Mutation_p.S153C|TMPRSS2_uc010gos.1_Missense_Mutation_p.S116C	NM_005656	NP_005647	O15393	TMPS2_HUMAN	transmembrane protease, serine 2 isoform 2	116	Extracellular (Potential).|LDL-receptor class A.				proteolysis	cytoplasm|extracellular region|integral to plasma membrane	scavenger receptor activity|serine-type endopeptidase activity		TMPRSS2/ERG(2499)|TMPRSS2/ETV1(24)	prostate(2523)|central_nervous_system(1)	2524		Prostate(19;4.48e-07)|all_epithelial(19;0.031)				CTCTATCCCAGAGTTGGAGCA	0.527		NaN	T	ERG|ETV1|ETV4|ETV5	prostate 								0	0	0	0.021022	0	38	12									
KLHL22	84861	broad.mit.edu	37	22	20812254	20812254	+	Missense_Mutation	SNP	G	G	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr22:20812254G>C	uc002zsl.1	-	5	1255	c.1146C>G	c.(1144-1146)ATC>ATG	p.I382M	KLHL22_uc011ahr.1_Missense_Mutation_p.I239M|KLHL22_uc002zsm.1_Missense_Mutation_p.I382M	NM_032775	NP_116164	Q53GT1	KLH22_HUMAN	kelch-like	382	Kelch 2.				cell division	Cul3-RING ubiquitin ligase complex				lung(1)	1	Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)			GCAGGGACTGGATCTGGAACC	0.602		NaN											0	0	0	0.013726	0	24	46									
MED15	51586	broad.mit.edu	37	22	20909319	20909319	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr22:20909319G>A	uc002zsp.2	+	5	415	c.335G>A	c.(334-336)GGG>GAG	p.G112E	MED15_uc002zsn.1_Missense_Mutation_p.G31E|MED15_uc002zso.2_Intron|MED15_uc002zsq.2_Missense_Mutation_p.G112E|MED15_uc010gso.2_Missense_Mutation_p.G112E|MED15_uc002zsr.2_Missense_Mutation_p.G86E|MED15_uc011ahs.1_Missense_Mutation_p.G86E|MED15_uc011aht.1_Missense_Mutation_p.G86E|MED15_uc002zss.2_Missense_Mutation_p.G31E	NM_001003891	NP_001003891	Q96RN5	MED15_HUMAN	mediator complex subunit 15 isoform a	112					regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|mediator complex	protein binding			skin(1)	1	all_cancers(11;2.07e-24)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)|Epithelial(17;0.209)			TCTCTGGGCGGGATGGGTAGC	0.647		NaN											0	0	0	0.009096	0	3	58									
DEPDC5	9681	broad.mit.edu	37	22	32275583	32275583	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr22:32275583G>A	uc003als.2	+	37	3927	c.3785G>A	c.(3784-3786)TGG>TAG	p.W1262*	DEPDC5_uc011als.1_Nonsense_Mutation_p.W1193*|DEPDC5_uc011alu.1_Nonsense_Mutation_p.W1293*|DEPDC5_uc011alv.1_RNA|DEPDC5_uc003alt.2_Nonsense_Mutation_p.W1284*|DEPDC5_uc003alu.2_Nonsense_Mutation_p.W711*|DEPDC5_uc003alv.2_RNA|DEPDC5_uc003alw.2_Nonsense_Mutation_p.W560*|DEPDC5_uc011alx.1_Nonsense_Mutation_p.W110*|DEPDC5_uc010gwk.2_Nonsense_Mutation_p.W288*|DEPDC5_uc011aly.1_Nonsense_Mutation_p.W110*	NM_014662	NP_055477	O75140	DEPD5_HUMAN	DEP domain containing 5 isoform 1	1262					intracellular signal transduction					ovary(4)|central_nervous_system(3)|pancreas(1)	8						CAGCGCAAGTGGTTTGAGGTG	0.612		NaN											0	0	0	0.01441	0	71	35									
C3orf31	132001	broad.mit.edu	37	3	11851124	11851124	+	Silent	SNP	C	C	T	rs140106641	byFrequency	TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr3:11851124C>T	uc003bwh.2	-	6	983	c.741G>A	c.(739-741)CAG>CAA	p.Q247Q	C3orf31_uc003bwj.2_Silent_p.Q247Q|C3orf31_uc003bwi.2_RNA|C3orf31_uc011auo.1_Silent_p.Q247Q	NM_138807	NP_620162	Q96BW9	MMP37_HUMAN	MMP37-like protein, mitochondrial precursor	247					protein import into mitochondrial matrix	extrinsic to mitochondrial inner membrane					0						ATGTCATCAGCTGAGTGAACT	0.398		NaN											0	0	0	0.027356	0	18	24									
ARPP21	10777	broad.mit.edu	37	3	35731587	35731587	+	Missense_Mutation	SNP	T	T	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr3:35731587T>G	uc003cgb.2	+	8	764	c.500T>G	c.(499-501)CTT>CGT	p.L167R	ARPP21_uc003cga.2_Missense_Mutation_p.L167R|ARPP21_uc011axy.1_Missense_Mutation_p.L167R|ARPP21_uc003cgf.2_Missense_Mutation_p.L3R	NM_016300	NP_057384	Q9UBL0	ARP21_HUMAN	cyclic AMP-regulated phosphoprotein, 21 kD	167	R3H.					cytoplasm	nucleic acid binding			ovary(2)|skin(1)	3						AGGATGATACTTTTGAAAATG	0.294		NaN											0	0	0	0.004482	0	9	21									
CTNNB1	1499	broad.mit.edu	37	3	41266113	41266113	+	Missense_Mutation	SNP	C	C	G	rs121913403		TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08			C	G	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr3:41266113C>G	uc010hia.1	+	4	266	c.110C>G	c.(109-111)TCT>TGT	p.S37C	CTNNB1_uc003ckp.2_Missense_Mutation_p.S37C|CTNNB1_uc003ckq.2_Missense_Mutation_p.S37C|CTNNB1_uc003ckr.2_Missense_Mutation_p.S37C|CTNNB1_uc011azf.1_Missense_Mutation_p.S30C|CTNNB1_uc011azg.1_Intron|uc010hib.1_RNA	NM_001904	NP_001895	P35222	CTNB1_HUMAN	beta-catenin	37			S -> C (in PTR, hepatoblastoma and ovarian cancer).|SG -> W (in hepatocellular carcinoma).|S -> F (in PTR).|S -> A (in MDB and hepatocellular carcinoma; enhances transactivation of target genes).|S -> Y (in hepatocellular carcinoma).		adherens junction assembly|androgen receptor signaling pathway|branching involved in ureteric bud morphogenesis|canonical Wnt receptor signaling pathway involved in negative regulation of apoptosis|canonical Wnt receptor signaling pathway involved in positive regulation of epithelial to mesenchymal transition|cell-cell adhesion|cell-matrix adhesion|cellular component disassembly involved in apoptosis|cellular response to growth factor stimulus|cellular response to indole-3-methanol|central nervous system vasculogenesis|cytoskeletal anchoring at plasma membrane|determination of dorsal/ventral asymmetry|dorsal/ventral axis specification|ectoderm development|embryonic axis specification|embryonic foregut morphogenesis|embryonic leg joint morphogenesis|endodermal cell fate commitment|endothelial tube morphogenesis|epithelial to mesenchymal transition|gastrulation with mouth forming second|glial cell fate determination|hair follicle morphogenesis|hair follicle placode formation|hindbrain development|liver development|lung cell differentiation|lung induction|lung-associated mesenchyme development|male genitalia development|mesenchymal cell proliferation involved in lung development|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of cell proliferation|negative regulation of chondrocyte differentiation|negative regulation of heart induction by canonical Wnt receptor signaling pathway|negative regulation of osteoclast differentiation|negative regulation of transcription from RNA polymerase II promoter|nephron tubule formation|odontogenesis of dentine-containing tooth|oocyte development|pancreas development|positive regulation of anti-apoptosis|positive regulation of apoptosis|positive regulation of branching involved in lung morphogenesis|positive regulation of epithelial cell proliferation involved in prostate gland development|positive regulation of fibroblast growth factor receptor signaling pathway|positive regulation of heparan sulfate proteoglycan biosynthetic process|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of MAPKKK cascade|positive regulation of muscle cell differentiation|positive regulation of osteoblast differentiation|positive regulation of transcription from RNA polymerase II promoter|protein localization at cell surface|proximal/distal pattern formation|regulation of angiogenesis|regulation of calcium ion import|regulation of centriole-centriole cohesion|regulation of centromeric sister chromatid cohesion|regulation of fibroblast proliferation|regulation of nephron tubule epithelial cell differentiation|regulation of protein localization at cell surface|regulation of smooth muscle cell proliferation|regulation of T cell proliferation|renal inner medulla development|renal outer medulla development|renal vesicle formation|response to drug|response to estradiol stimulus|Schwann cell proliferation|smooth muscle cell differentiation|synapse organization|synaptic vesicle transport|T cell differentiation in thymus|thymus development|trachea formation	APC-Axin-1-beta-catenin complex|Axin-APC-beta-catenin-GSK3B complex|beta-catenin-TCF7L2 complex|catenin complex|cell cortex|cell-substrate adherens junction|centrosome|dendritic shaft|desmosome|fascia adherens|internal side of plasma membrane|lamellipodium|lateral plasma membrane|microvillus membrane|perinuclear region of cytoplasm|protein-DNA complex|synapse|transcription factor complex|Z disc|zonula adherens	alpha-catenin binding|androgen receptor binding|cadherin binding|estrogen receptor binding|I-SMAD binding|ion channel binding|protein binding|protein C-terminus binding|protein kinase binding|protein phosphatase binding|R-SMAD binding|RPTP-like protein binding|signal transducer activity|specific RNA polymerase II transcription factor activity|structural molecule activity|transcription coactivator activity|transcription regulatory region DNA binding	p.S37F(147)|p.S37C(124)|p.A5_A80del(63)|p.S37A(59)|p.S37Y(23)|p.S37P(16)|p.H24_S47del(9)|p.A5_A80>D(7)|p.A5_Q143del(7)|p.Q28_H134del(5)|p.W25_I140del(4)|p.V22_G38del(3)|p.T3_A126del(2)|p.M5_N141>D(2)|p.D32_S47del(2)|p.V22_L139>V(2)|p.A5_Y142>D(2)|p.A5fs*7(2)|p.?(2)|p.L10_N141del(2)|p.D6_A43del(1)|p.E9_S47del(1)|p.Q28_Q61del(1)|p.A20_R151del(1)|p.A20_N141del(1)|p.D11_Y142>H(1)|p.H24_G38del(1)|p.Y30_A97del(1)|p.A20_A80del(1)|p.Q28_A43del(1)|p.E15_I140>V(1)|p.D17_P128del(1)|p.H24_M131del(1)|p.L7_I140del(1)|p.K19_Y142>V(1)|p.A20_L148del(1)|p.V22_A80del(1)|p.V22_G80>NNNNN(1)|p.GIHS34?(1)|p.A20_Q143del(1)|p.A13_R151del(1)|p.S23_I140del(1)|p.M1_A87del(1)|p.V22_T102del(1)|p.S23_A39del(1)|p.A21_A80del(1)|p.P16_K133del(1)|p.D6_I140del(1)|p.Q28_I140del(1)|p.E9_A80del(1)|p.G34_S37del(1)|p.I35_S37>T(1)|p.I35_K170del(1)|p.M14_S45del(1)|p.M8_G50del(1)|p.A5_G80>(1)|p.S37S(1)|p.S37T(1)|p.V22_S71>A(1)|p.A5_T59del(1)|p.M1_V173del(1)|p.A5_R90del(1)|p.V22_Y64del(1)|p.M8_A80del(1)|p.S33_S37del(1)|p.E9_I140del(1)|p.Y30_T40del(1)|p.M1_T42del(1)|p.S37_G38>W(1)|p.A5_Q143>E(1)|p.I35_G38del(1)|p.H36_E53>L(1)|p.A5_Q72del(1)|p.Y30_A80del(1)|p.D32fs*9(1)|p.S37_A39>S(1)|p.D6_K133del(1)|p.A5_T42del(1)|p.A5_D144>D(1)|p.A5_T40del(1)|p.D17_A126del(1)|p.A5_E54del(1)|p.I35_T41del(1)|p.W25_A80del(1)|p.A20_Q72del(1)|p.A20_S111del(1)	CTNNB1/PLAG1(60)	liver(806)|soft_tissue(609)|large_intestine(243)|endometrium(222)|kidney(172)|stomach(157)|central_nervous_system(139)|ovary(104)|skin(97)|pancreas(91)|adrenal_gland(85)|pituitary(81)|salivary_gland(62)|haematopoietic_and_lymphoid_tissue(57)|thyroid(55)|biliary_tract(41)|lung(38)|prostate(24)|bone(20)|small_intestine(17)|cervix(9)|parathyroid(9)|urinary_tract(8)|breast(7)|oesophagus(5)|NS(3)|pleura(2)|upper_aerodigestive_tract(2)|eye(1)	3166				KIRC - Kidney renal clear cell carcinoma(284;0.0028)|Kidney(284;0.00294)	Lithium(DB01356)	GGAATCCATTCTGGTGCCACT	0.498	S37F(HUTU80_SMALL_INTESTINE)|S37C(SNU398_LIVER)|S37C(JHUEM2_ENDOMETRIUM)	15	H|Mis|T	PLAG1	colorectal|cvarian| hepatoblastoma|others|pleomorphic salivary adenoma				Pilomatrixoma_Familial_Clustering_of				0	0	0	0.008871	0	19	20									
MAP4	4134	broad.mit.edu	37	3	47913544	47913544	+	Missense_Mutation	SNP	T	T	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr3:47913544T>A	uc003csb.2	-	11	2895	c.2369A>T	c.(2368-2370)AAG>ATG	p.K790M	MAP4_uc003csc.3_Missense_Mutation_p.K790M|MAP4_uc003crw.2_5'Flank|MAP4_uc003crx.2_Missense_Mutation_p.K50M|MAP4_uc011bbe.1_Missense_Mutation_p.K541M|MAP4_uc003cry.2_Missense_Mutation_p.K525M|MAP4_uc003csa.3_Missense_Mutation_p.K525M|MAP4_uc003crz.3_RNA|MAP4_uc003csd.2_Missense_Mutation_p.K525M	NM_002375	NP_002366	P27816	MAP4_HUMAN	microtubule-associated protein 4 isoform 1	790					negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	protein binding|structural molecule activity			ovary(2)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.000721)|KIRC - Kidney renal clear cell carcinoma(197;0.00641)|Kidney(197;0.00736)		AGAAGCTGGCTTGGATGGTGA	0.562		NaN											0	0	0	0.01441	0	98	150									
DUSP7	1849	broad.mit.edu	37	3	52090150	52090150	+	Missense_Mutation	SNP	C	C	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr3:52090150C>A	uc003dct.2	-	1	312	c.233G>T	c.(232-234)CGG>CTG	p.R78L	DUSP7_uc010hma.2_Missense_Mutation_p.R78L	NM_001947	NP_001938	Q16829	DUS7_HUMAN	dual specificity phosphatase 7	78	Rhodanese.				inactivation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	MAP kinase tyrosine/serine/threonine phosphatase activity|protein binding|protein tyrosine phosphatase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;5.14e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CTCGTGCGGCCGGCAGTCGAG	0.627		NaN											1	0	2.0095e-06	0.001984	2.06774e-06	4	15									
POC1A	25886	broad.mit.edu	37	3	52179937	52179937	+	Missense_Mutation	SNP	T	T	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr3:52179937T>C	uc003dcu.2	-	6	922	c.604A>G	c.(604-606)ATT>GTT	p.I202V	POC1A_uc003dcv.2_Missense_Mutation_p.I164V|POC1A_uc003dcw.2_Missense_Mutation_p.I202V	NM_015426	NP_056241	Q8NBT0	POC1A_HUMAN	WD repeat domain 51A isoform 1	202	WD 5.					centriole|microtubule basal body					0						GCAGCGGCAATGCACGTCCCA	0.592		NaN											0	0	0	0.015359	0	28	52									
TLR9	54106	broad.mit.edu	37	3	52256622	52256622	+	Silent	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr3:52256622G>A	uc003dda.1	-	2	2344	c.1710C>T	c.(1708-1710)TTC>TTT	p.F570F	TLR9_uc003ddb.2_Silent_p.F667F	NM_017442	NP_059138	Q9NR96	TLR9_HUMAN	toll-like receptor 9 isoform A precursor	570	LRR 18.|Extracellular (Potential).				defense response to bacterium|fibroblast growth factor receptor signaling pathway|I-kappaB phosphorylation|inflammatory response|innate immune response|insulin receptor signaling pathway|maintenance of gastrointestinal epithelium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of NF-kappaB transcription factor activity|negative regulation of toll-like receptor signaling pathway|positive regulation of chemokine production|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interferon-alpha biosynthetic process|positive regulation of interferon-beta biosynthetic process|positive regulation of interferon-beta production|positive regulation of interferon-gamma biosynthetic process|positive regulation of interleukin-10 production|positive regulation of interleukin-12 production|positive regulation of interleukin-18 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of toll-like receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor production|response to molecule of bacterial origin	apical plasma membrane|basolateral plasma membrane|early phagosome|endoplasmic reticulum membrane|endosome membrane|extracellular region|integral to membrane|lysosome	interleukin-1 receptor binding|siRNA binding|transmembrane receptor activity			large_intestine(2)|skin(2)	4				BRCA - Breast invasive adenocarcinoma(193;2.41e-05)|Kidney(197;0.000537)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)	Chloroquine(DB00608)	GGTGAGCCACGAAGCTGAAGT	0.642		NaN											0	0	0	0.01892	0	24	23									
TMEM110	375346	broad.mit.edu	37	3	52883817	52883817	+	Missense_Mutation	SNP	C	C	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr3:52883817C>A	uc003dge.2	-	4	499	c.418G>T	c.(418-420)GGC>TGC	p.G140C	TMEM110_uc003dgc.3_Missense_Mutation_p.G140C	NM_198563	NP_940965	Q86TL2	TM110_HUMAN	transmembrane protein 110	140						integral to membrane				large_intestine(1)	1				BRCA - Breast invasive adenocarcinoma(193;7.72e-05)|Kidney(197;0.000777)|KIRC - Kidney renal clear cell carcinoma(197;0.000915)|OV - Ovarian serous cystadenocarcinoma(275;0.0541)		CCATATTCGCCGAAGCGCAGG	0.627		NaN											1	0	9.4991e-31	0.01441	1.0621e-30	58	14									
HESX1	8820	broad.mit.edu	37	3	57232284	57232284	+	Missense_Mutation	SNP	G	G	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr3:57232284G>T	uc003din.3	-	4	833	c.499C>A	c.(499-501)CAT>AAT	p.H167N		NM_003865	NP_003856	Q9UBX0	HESX1_HUMAN	HESX homeobox 1	167	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0109)|Kidney(284;0.0126)		GATTCTCTATGGGACCTTTTC	0.299		NaN											1	0	0.00024832	0.009096	0.000251867	3	21									
FLNB	2317	broad.mit.edu	37	3	58062849	58062849	+	Silent	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr3:58062849C>T	uc003djj.2	+	2	534	c.369C>T	c.(367-369)ATC>ATT	p.I123I	FLNB_uc010hne.2_Silent_p.I123I|FLNB_uc003djk.2_Silent_p.I123I|FLNB_uc010hnf.2_Silent_p.I123I|FLNB_uc003djl.2_5'Flank|FLNB_uc003djm.2_5'Flank	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	123	Actin-binding.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		ACTACTCCATCTCCATGCCCG	0.552		NaN											0	0	0	0.007835	0	37	60									
C3orf64	285203	broad.mit.edu	37	3	69031975	69031975	+	Missense_Mutation	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr3:69031975C>T	uc003dnl.2	-	15	1606	c.1201G>A	c.(1201-1203)GAT>AAT	p.D401N	C3orf64_uc003dnj.2_Missense_Mutation_p.D80N|C3orf64_uc003dnk.2_Missense_Mutation_p.D317N|C3orf64_uc011bfw.1_RNA	NM_173654	NP_775925	Q5NDL2	AER61_HUMAN	AER61 glycosyltransferase	401						extracellular region	transferase activity, transferring glycosyl groups			ovary(1)	1		Lung NSC(201;0.126)		BRCA - Breast invasive adenocarcinoma(55;4.61e-05)|Epithelial(33;0.000291)|LUSC - Lung squamous cell carcinoma(21;0.0127)|KIRC - Kidney renal clear cell carcinoma(39;0.216)		TACTTGTAATCAACAATCTGG	0.388		NaN											0	0	0	0.00308	0	6	17									
OR5AC2	81050	broad.mit.edu	37	3	97806241	97806241	+	Silent	SNP	T	T	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr3:97806241T>G	uc011bgs.1	+	1	225	c.225T>G	c.(223-225)ACT>ACG	p.T75T		NM_054106	NP_473447	Q9NZP5	O5AC2_HUMAN	olfactory receptor, family 5, subfamily AC,	75	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						ATGCTTGTACTTCAACCTCTA	0.428		NaN											0	0	0	0.01441	0	46	125									
ALCAM	214	broad.mit.edu	37	3	105269058	105269058	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr3:105269058G>A	uc003dvx.2	+	12	2002	c.1462G>A	c.(1462-1464)GAA>AAA	p.E488K	ALCAM_uc003dvw.1_Missense_Mutation_p.E488K|ALCAM_uc003dvy.2_Missense_Mutation_p.E488K|ALCAM_uc010hpp.2_Missense_Mutation_p.E210K|ALCAM_uc003dvz.2_Missense_Mutation_p.E122K	NM_001627	NP_001618	Q13740	CD166_HUMAN	activated leukocyte cell adhesion molecule	488	Extracellular (Potential).|Ig-like C2-type 3.				cell adhesion|signal transduction	integral to membrane	receptor binding			ovary(2)|breast(1)	3						TTGCACAGCAGAAAACCAACT	0.333		NaN											0	0	0	0.027356	0	25	19									
ACPP	55	broad.mit.edu	37	3	132056364	132056364	+	Missense_Mutation	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr3:132056364C>T	uc010htp.2	+	5	611	c.521C>T	c.(520-522)TCA>TTA	p.S174L	ACPP_uc003eon.3_Intron|ACPP_uc003eop.3_Missense_Mutation_p.S174L	NM_001099	NP_001090	P15309	PPAP_HUMAN	acid phosphatase, prostate short isoform	174						extracellular region|lysosomal membrane	5'-nucleotidase activity|acid phosphatase activity			ovary(1)	1						ACTTTGAAATCAGAGGAATTC	0.398		NaN											0	0	0	0.01441	0	53	10									
ETV5	2119	broad.mit.edu	37	3	185766491	185766491	+	Silent	SNP	G	G	A	rs151057501		TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr3:185766491G>A	uc003fpz.2	-	13	1717	c.1470C>T	c.(1468-1470)CCC>CCT	p.P490P	ETV5_uc003fpy.2_Silent_p.P532P	NM_004454	NP_004445	P41161	ETV5_HUMAN	ets variant gene 5 (ets-related molecule)	490					cellular response to oxidative stress	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			ovary(2)|skin(2)|breast(1)	5	all_cancers(143;4.06e-12)|Ovarian(172;0.0386)|Breast(254;0.247)		OV - Ovarian serous cystadenocarcinoma(80;1.62e-24)			GGAGGTAAGCGGGGCTGTCTT	0.597		NaN	T	TMPRSS2|SCL45A3	Prostate 								0	0	0	0.023175	0	33	70									
ATP13A3	79572	broad.mit.edu	37	3	194147857	194147857	+	Silent	SNP	A	A	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr3:194147857A>C	uc003fty.3	-	28	3474	c.3072T>G	c.(3070-3072)GGT>GGG	p.G1024G	ATP13A3_uc003ftx.3_5'Flank	NM_024524	NP_078800	Q9H7F0	AT133_HUMAN	ATPase type 13A3	1024					ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(1)	1	all_cancers(143;6.01e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;3.83e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;5.98e-05)		CCCAAAAAAAACCCAAAGATT	0.388		NaN											0	0	0	0.013114	0	40	10									
PROM1	8842	broad.mit.edu	37	4	16077403	16077403	+	Missense_Mutation	SNP	T	T	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr4:16077403T>G	uc003goo.2	-	1	339	c.127A>C	c.(127-129)ACC>CCC	p.T43P	PROM1_uc003gor.2_Missense_Mutation_p.T43P|PROM1_uc003gos.2_Missense_Mutation_p.T43P|PROM1_uc003got.2_Missense_Mutation_p.T43P|PROM1_uc003gou.2_Missense_Mutation_p.T43P|PROM1_uc003gop.2_Missense_Mutation_p.T43P|PROM1_uc003goq.3_Missense_Mutation_p.T43P|PROM1_uc010iec.1_5'UTR	NM_006017	NP_006008	O43490	PROM1_HUMAN	prominin 1 isoform 1	43	Extracellular (Potential).				camera-type eye photoreceptor cell differentiation|photoreceptor cell maintenance|retina layer formation	apical plasma membrane|cell surface|integral to plasma membrane|microvillus membrane|photoreceptor outer segment membrane|plasma membrane	beta-actinin binding|cadherin binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)|central_nervous_system(1)	7						GAGTCTTGGGTCTCATAATTT	0.488		NaN											0	0	0	0.007413	0	17	0									
PPARGC1A	10891	broad.mit.edu	37	4	23815314	23815314	+	Silent	SNP	T	T	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr4:23815314T>G	uc003gqs.2	-	8	1912	c.1792A>C	c.(1792-1794)AGA>CGA	p.R598R	PPARGC1A_uc003gqt.2_RNA|PPARGC1A_uc011bxp.1_RNA|PPARGC1A_uc010ier.1_RNA	NM_013261	NP_037393	Q9UBK2	PRGC1_HUMAN	peroxisome proliferator-activated receptor	598	Arg/Ser-rich.				androgen receptor signaling pathway|brown fat cell differentiation|cellular glucose homeostasis|digestion|fatty acid oxidation|gluconeogenesis|mitochondrion organization|mRNA processing|neuron death|positive regulation of fatty acid oxidation|positive regulation of gluconeogenesis|positive regulation of histone acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|protein complex assembly|protein stabilization|response to muscle activity|response to starvation|RNA splicing|temperature homeostasis|transcription initiation from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	androgen receptor binding|DNA binding|ligand-dependent nuclear receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|RNA binding|RNA polymerase II transcription cofactor activity|transcription factor binding			ovary(2)|lung(2)|kidney(2)|skin(2)	8		Breast(46;0.0503)				AAGGTTTACCTTGAAGAGGAT	0.398		NaN											0	0	0	0.028581	0	11	22									
RBM47	54502	broad.mit.edu	37	4	40438583	40438583	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr4:40438583G>A	uc003gvc.2	-	5	1915	c.1205C>T	c.(1204-1206)TCT>TTT	p.S402F	RBM47_uc003gvd.2_Intron|RBM47_uc003gve.2_RNA|RBM47_uc011bys.1_Missense_Mutation_p.S364F	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	RNA binding motif protein 47 isoform a	402						nucleus	nucleotide binding|RNA binding			breast(3)	3						ACGACCAGCAGAATATCCCCC	0.507		NaN											0	0	0	0.01441	0	79	171									
RBM47	54502	broad.mit.edu	37	4	40440104	40440104	+	Silent	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr4:40440104G>A	uc003gvc.2	-	4	1517	c.807C>T	c.(805-807)TTC>TTT	p.F269F	RBM47_uc003gvd.2_Silent_p.F269F|RBM47_uc003gve.2_RNA|RBM47_uc011bys.1_Silent_p.F231F|RBM47_uc003gvg.1_Silent_p.F269F	NM_001098634	NP_001092104	A0AV96	RBM47_HUMAN	RNA binding motif protein 47 isoform a	269	RRM 3.					nucleus	nucleotide binding|RNA binding			breast(3)	3						AGCCGGGGTTGAACTGGCCGA	0.592		NaN											0	0	0	0.009718	0	41	52									
KIT	3815	broad.mit.edu	37	4	55564535	55564535	+	Silent	SNP	A	A	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr4:55564535A>T	uc010igr.2	+	3	510	c.423A>T	c.(421-423)CCA>CCT	p.P141P	KIT_uc010igs.2_Silent_p.P141P	NM_000222	NP_000213	P10721	KIT_HUMAN	v-kit Hardy-Zuckerman 4 feline sarcoma viral	141	Extracellular (Potential).|Ig-like C2-type 2.				male gonad development|transmembrane receptor protein tyrosine kinase signaling pathway	extracellular space|integral to membrane	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity			soft_tissue(3273)|haematopoietic_and_lymphoid_tissue(1572)|skin(99)|testis(49)|bone(21)|genital_tract(18)|kidney(17)|ovary(16)|salivary_gland(15)|large_intestine(11)|thymus(6)|lung(6)|central_nervous_system(4)|NS(3)|eye(2)|endometrium(2)|breast(1)|stomach(1)|autonomic_ganglia(1)|pancreas(1)	5118	all_cancers(7;0.00453)|all_lung(4;0.000565)|Lung NSC(11;0.00129)|all_epithelial(27;0.0104)|Glioma(25;0.08)|all_neural(26;0.101)		LUSC - Lung squamous cell carcinoma(32;0.000276)|Epithelial(7;0.209)	Colorectal(1;0.0276)|COAD - Colon adenocarcinoma(1;0.171)	Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	TCACAGACCCAGAAGTGACCA	0.512		1	Mis|O		GIST|AML|TGCT|mastocytosis|mucosal melanoma	GIST|epithelioma	Piebald trait		Mast_Cell_disease_Familial_Clustering_of|Piebaldism|Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Gastrointestinal_Stromal_Tumors				0	0	0	0.024245	0	12	29									
KIAA1211	57482	broad.mit.edu	37	4	57181275	57181275	+	Missense_Mutation	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr4:57181275C>T	uc003hbk.2	+	8	1998	c.1607C>T	c.(1606-1608)CCC>CTC	p.P536L	KIAA1211_uc010iha.2_Missense_Mutation_p.P529L|KIAA1211_uc011bzz.1_Missense_Mutation_p.P446L|KIAA1211_uc003hbm.1_Missense_Mutation_p.P422L	NM_020722	NP_065773	Q6ZU35	K1211_HUMAN	hypothetical protein LOC57482	536										ovary(1)|skin(1)	2	Glioma(25;0.08)|all_neural(26;0.101)					ATGCCCCGGCCCTACACGTTC	0.642		NaN											0	0	0	0.008871	0	15	6									
DSPP	1834	broad.mit.edu	37	4	88534106	88534106	+	Silent	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr4:88534106C>T	uc003hqu.2	+	4	888	c.768C>T	c.(766-768)GAC>GAT	p.D256D		NM_014208	NP_055023	Q9NZW4	DSPP_HUMAN	dentin sialophosphoprotein preproprotein	256					biomineral tissue development|ossification|skeletal system development	proteinaceous extracellular matrix	calcium ion binding|collagen binding|extracellular matrix structural constituent			central_nervous_system(1)	1		Hepatocellular(203;0.114)|all_hematologic(202;0.236)		OV - Ovarian serous cystadenocarcinoma(123;0.000508)		AGGATGAAGACGAGGGTTCTG	0.507		NaN											0	0	0	0.024245	0	13	27									
PRDM5	11107	broad.mit.edu	37	4	121616352	121616352	+	Missense_Mutation	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr4:121616352C>T	uc003idn.2	-	16	2057	c.1807G>A	c.(1807-1809)GAA>AAA	p.E603K	PRDM5_uc003ido.2_Missense_Mutation_p.E572K|PRDM5_uc010ine.2_3'UTR	NM_018699	NP_061169	Q9NQX1	PRDM5_HUMAN	PR domain containing 5	603	C2H2-type 16.				histone deacetylation|histone H3-K9 methylation|mitotic cell cycle|negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	repressing transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)|pancreas(1)	2						AACTGGCATTCTGCCAGGGGA	0.428		NaN											0	0	0	0.024334	0	24	37									
FSTL5	56884	broad.mit.edu	37	4	162421208	162421208	+	Missense_Mutation	SNP	T	T	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr4:162421208T>C	uc003iqh.2	-	12	1854	c.1418A>G	c.(1417-1419)CAG>CGG	p.Q473R	FSTL5_uc003iqi.2_Missense_Mutation_p.Q472R|FSTL5_uc010iqv.2_Missense_Mutation_p.Q463R	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	473						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		AATGTGCCTCTGAAATTCACA	0.338		NaN											0	0	0	0.00308	0	7	2									
IRX2	153572	broad.mit.edu	37	5	2749625	2749625	+	Missense_Mutation	SNP	T	T	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr5:2749625T>C	uc003jda.2	-	2	768	c.526A>G	c.(526-528)AAC>GAC	p.N176D	C5orf38_uc003jdc.2_5'Flank|C5orf38_uc011cmg.1_5'Flank|C5orf38_uc011cmh.1_5'Flank|C5orf38_uc011cmi.1_5'Flank|C5orf38_uc011cmj.1_5'Flank|IRX2_uc003jdb.2_Missense_Mutation_p.N176D	NM_001134222	NP_001127694	Q9BZI1	IRX2_HUMAN	iroquois homeobox 2	176						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1				GBM - Glioblastoma multiforme(108;0.204)		GTCATCTTGTTCTCCTTCTTG	0.597		NaN											0	0	0	0.025465	0	31	91									
TRIO	7204	broad.mit.edu	37	5	14507245	14507245	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr5:14507245G>A	uc003jff.2	+	56	8633	c.8627G>A	c.(8626-8628)CGC>CAC	p.R2876H	TRIO_uc003jfg.2_RNA	NM_007118	NP_009049	O75962	TRIO_HUMAN	triple functional domain (PTPRF interacting)	2876	Protein kinase.				apoptosis|axon guidance|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|transmembrane receptor protein tyrosine phosphatase signaling pathway	cytosol	ATP binding|protein serine/threonine kinase activity|Rho guanyl-nucleotide exchange factor activity	p.R2876C(2)		skin(4)|central_nervous_system(3)|ovary(3)|large_intestine(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|kidney(1)	18	Lung NSC(4;0.000742)					GACCAGGGTCGCCTCCTGGAC	0.567		NaN											0	0	0	0.00499	0	15	53									
FBXL7	23194	broad.mit.edu	37	5	15500819	15500819	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr5:15500819G>A	uc003jfn.1	+	1	515	c.34G>A	c.(34-36)GAG>AAG	p.E12K		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	12					ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						GTACGGCAGTGAGGGTGAGTG	0.692		NaN											0	0	0	0.01441	0	100	280									
MYO10	4651	broad.mit.edu	37	5	16694540	16694540	+	Missense_Mutation	SNP	A	A	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr5:16694540A>G	uc003jft.3	-	27	4208	c.3740T>C	c.(3739-3741)ATG>ACG	p.M1247T	MYO10_uc011cnc.1_Missense_Mutation_p.M126T|MYO10_uc011cnd.1_Missense_Mutation_p.M604T|MYO10_uc011cne.1_Missense_Mutation_p.M604T|MYO10_uc010itx.2_Missense_Mutation_p.M870T	NM_012334	NP_036466	Q9HD67	MYO10_HUMAN	myosin X	1247	PH 1.				axon guidance|signal transduction	myosin complex	actin binding|ATP binding|motor activity			ovary(2)|pancreas(1)	3						TTCAAAGTACATCAGCTTGGA	0.562		NaN											0	0	0	0.01441	0	58	134									
CDC20B	166979	broad.mit.edu	37	5	54410097	54410097	+	Silent	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr5:54410097C>T	uc003jpo.1	-	12	1684	c.1509G>A	c.(1507-1509)CGG>CGA	p.R503R	CDC20B_uc003jpn.1_Silent_p.R499R|CDC20B_uc010ivu.1_Silent_p.R461R	NM_152623	NP_689836	Q86Y33	CD20B_HUMAN	CDC20 cell division cycle 20 homolog B isoform	503	WD 7.										0		Lung NSC(810;0.000744)|Breast(144;0.159)|Prostate(74;0.194)	LUSC - Lung squamous cell carcinoma(15;0.225)			cagaaaacacccgggtctggt	0.199		NaN											0	0	0	0.013726	0	35	74									
CMYA5	202333	broad.mit.edu	37	5	79030171	79030171	+	Missense_Mutation	SNP	G	G	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr5:79030171G>T	uc003kgc.2	+	2	5655	c.5583G>T	c.(5581-5583)TTG>TTT	p.L1861F		NM_153610	NP_705838	Q8N3K9	CMYA5_HUMAN	cardiomyopathy associated 5	1861						perinuclear region of cytoplasm				ovary(6)|pancreas(2)|lung(1)	9		Lung NSC(167;0.00296)|all_lung(232;0.00327)|Ovarian(174;0.0262)		OV - Ovarian serous cystadenocarcinoma(54;9.85e-46)|Epithelial(54;3.38e-40)|all cancers(79;3.43e-35)		GAGAGAATTTGCCTTTGGAAC	0.343		NaN											1	0	2.17888e-05	0.006214	2.2259e-05	8	34									
WDR36	134430	broad.mit.edu	37	5	110441021	110441021	+	Missense_Mutation	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr5:110441021C>T	uc003kpd.2	+	10	1340	c.1223C>T	c.(1222-1224)TCC>TTC	p.S408F	WDR36_uc010jbu.2_RNA	NM_139281	NP_644810	Q8NI36	WDR36_HUMAN	WD repeat domain 36	408	WD 5.				response to stimulus|rRNA processing|visual perception	small-subunit processome				ovary(1)|skin(1)	2		all_cancers(142;2.72e-05)|all_epithelial(76;4.4e-07)|Prostate(80;0.00955)|Lung NSC(167;0.0418)|Ovarian(225;0.0443)|Colorectal(57;0.0465)|all_lung(232;0.0508)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;1.39e-08)|Epithelial(69;1.82e-07)|all cancers(49;2.04e-05)|COAD - Colon adenocarcinoma(37;0.111)		CAGTCATTTTCCACGGTACAT	0.348		NaN											0	0	0	0.001984	0	6	19									
GPX3	2878	broad.mit.edu	37	5	150407000	150407000	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr5:150407000C>T	uc011dcm.1	+	5	584	c.367C>T	c.(367-369)CGA>TGA	p.R123*	GPX3_uc003ltc.2_RNA|GPX3_uc003ltd.2_RNA	NM_002084	NP_002075	P22352	GPX3_HUMAN	glutathione peroxidase 3 precursor	123					hydrogen peroxide catabolic process|protein homotetramerization|response to lipid hydroperoxide	extracellular space	glutathione peroxidase activity|selenium binding|transcription factor binding				0		Medulloblastoma(196;0.091)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glutathione(DB00143)	CAGGTATGTCCGACCAGGTGG	0.493		NaN											0	0	0	0.024334	0	23	59									
GPX3	2878	broad.mit.edu	37	5	150407039	150407039	+	Missense_Mutation	SNP	G	G	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr5:150407039G>C	uc011dcm.1	+	5	623	c.406G>C	c.(406-408)GAG>CAG	p.E136Q	GPX3_uc003ltc.2_RNA|GPX3_uc003ltd.2_RNA	NM_002084	NP_002075	P22352	GPX3_HUMAN	glutathione peroxidase 3 precursor	136					hydrogen peroxide catabolic process|protein homotetramerization|response to lipid hydroperoxide	extracellular space	glutathione peroxidase activity|selenium binding|transcription factor binding				0		Medulloblastoma(196;0.091)|all_hematologic(541;0.207)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Glutathione(DB00143)	CCAGCTCTTTGAGAAAGGGGA	0.527		NaN											0	0	0	0.020292	0	14	64									
NOP16	51491	broad.mit.edu	37	5	175811366	175811366	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr5:175811366G>A	uc011dfl.1	-	5	403	c.403C>T	c.(403-405)CGT>TGT	p.R135C	NOP16_uc003med.2_Intron|NOP16_uc003mee.2_Intron	NM_016391	NP_057475	Q9Y3C1	NOP16_HUMAN	NOP16 nucleolar protein homolog	135						nucleolus				ovary(1)|central_nervous_system(1)	2						TTCTCATCACGGGCCATGGCC	0.458		NaN											0	0	0	0.01892	0	19	50									
HIST1H1E	3008	broad.mit.edu	37	6	26156945	26156945	+	Missense_Mutation	SNP	G	G	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr6:26156945G>T	uc003ngq.2	+	1	387	c.327G>T	c.(325-327)AAG>AAT	p.K109N	HIST1H2BD_uc003ngr.2_5'Flank|HIST1H2BD_uc003ngs.2_5'Flank	NM_005321	NP_005312	P10412	H14_HUMAN	histone cluster 1, H1e	109	H15.				nucleosome assembly	nucleosome|nucleus	DNA binding|protein binding			large_intestine(1)|ovary(1)	2						AACTCAACAAGAAGGCGGCCT	0.622		NaN											1	0	0.00010058	0.013537	0.000102382	13	28									
PBX2	5089	broad.mit.edu	37	6	32157485	32157485	+	Missense_Mutation	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr6:32157485C>T	uc003oav.1	-	1	479	c.208G>A	c.(208-210)GAG>AAG	p.E70K	PBX2_uc003oaw.2_Missense_Mutation_p.E70K	NM_002586	NP_002577	P40425	PBX2_HUMAN	pre-B-cell leukemia homeobox 2	70							transcription factor binding			ovary(1)	1						GCCTGGGCCTCGTCCAGGCTC	0.647		NaN											0	0	0	0.00874	0	31	34									
BRD2	6046	broad.mit.edu	37	6	32944130	32944130	+	Silent	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr6:32944130C>T	uc003ocn.3	+	6	2415	c.714C>T	c.(712-714)CTC>CTT	p.L238L	BRD2_uc003oco.2_RNA|BRD2_uc003ocq.3_Silent_p.L238L|BRD2_uc003ocp.3_Silent_p.L118L|BRD2_uc010juh.2_Silent_p.L238L	NM_005104	NP_005095	P25440	BRD2_HUMAN	bromodomain containing 2	238					spermatogenesis	nucleus	protein serine/threonine kinase activity			central_nervous_system(3)|stomach(2)	5						CCACTGTCCTCAACATTCCCC	0.567		NaN											0	0	0	0.010771	0	37	72									
GLP1R	2740	broad.mit.edu	37	6	39047367	39047367	+	Silent	SNP	C	C	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr6:39047367C>A	uc003ooj.3	+	11	1131	c.1071C>A	c.(1069-1071)ATC>ATA	p.I357I	GLP1R_uc003ooh.2_RNA|GLP1R_uc003ooi.2_RNA	NM_002062	NP_002053	P43220	GLP1R_HUMAN	glucagon-like peptide 1 receptor precursor	357	Helical; Name=6; (Potential).				activation of adenylate cyclase activity|cAMP-mediated signaling|elevation of cytosolic calcium ion concentration|energy reserve metabolic process|regulation of insulin secretion	integral to membrane|plasma membrane	glucagon receptor activity|peptide receptor activity, G-protein coupled			lung(3)|breast(1)|pancreas(1)	5					Exenatide(DB01276)|Glucagon recombinant(DB00040)	TGACACTCATCCCCCTGCTGG	0.567		NaN											1	0	9.78306e-22	0.009535	1.06861e-21	24	55									
PGC	5225	broad.mit.edu	37	6	41708252	41708252	+	Silent	SNP	G	G	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr6:41708252G>C	uc003ora.1	-	6	793	c.744C>G	c.(742-744)CTC>CTG	p.L248L		NM_002630	NP_002621	P20142	PEPC_HUMAN	progastricsin (pepsinogen C) precursor	248					digestion|proteolysis	extracellular space	aspartic-type endopeptidase activity				0	Ovarian(28;0.0355)|Colorectal(47;0.121)		Epithelial(12;0.000132)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00507)			TCTGCCAGTAGAGTTCCTGGG	0.617		NaN											0	0	0	0.01441	0	64	87									
CCND3	896	broad.mit.edu	37	6	42016405	42016405	+	Translation_Start_Site	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr6:42016405C>T	uc003orp.2	-	1	206	c.-211G>A	c.(-213--209)GGGTG>GGATG		CCND3_uc011duk.1_Translation_Start_Site|CCND3_uc011dum.1_Translation_Start_Site|TAF8_uc003orr.2_5'Flank|TAF8_uc003ors.2_5'Flank|TAF8_uc003ort.2_5'Flank|TAF8_uc003oru.1_5'Flank|TAF8_uc003orv.1_5'Flank|TAF8_uc011dun.1_5'Flank	NM_001136017	NP_001129489	P30281	CCND3_HUMAN	cyclin D3 isoform 1						cell division|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex|cytoplasm|membrane|nucleus	protein kinase binding				0	Colorectal(47;0.121)		Epithelial(12;0.000178)|STAD - Stomach adenocarcinoma(11;0.000204)|Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)			CCAGTCTCCACCCCTGCAGTG	0.672		NaN	T	IGH@	MM								0	0	0	0.006122	0	14	22									
ABCC10	89845	broad.mit.edu	37	6	43400684	43400684	+	Silent	SNP	C	C	T	rs145760020		TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr6:43400684C>T	uc003ouy.1	+	3	1181	c.966C>T	c.(964-966)CAC>CAT	p.H322H	ABCC10_uc003ouz.1_Silent_p.H279H|ABCC10_uc010jyo.1_5'Flank	NM_033450	NP_258261	Q5T3U5	MRP7_HUMAN	ATP-binding cassette, sub-family C, member 10	322	ABC transmembrane type-1 1.|Helical; (Potential).					integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(6)|central_nervous_system(1)	7	all_lung(25;0.00536)		Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0152)|OV - Ovarian serous cystadenocarcinoma(102;0.0804)			CACTAAGCCACGGCCTGCTCT	0.587		NaN											0	0	0	0.025465	0	34	57									
SLC25A27	9481	broad.mit.edu	37	6	46623750	46623750	+	Missense_Mutation	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr6:46623750C>T	uc003oyh.2	+	2	528	c.277C>T	c.(277-279)CCC>TCC	p.P93S	SLC25A27_uc011dwb.1_Missense_Mutation_p.P93S|SLC25A27_uc003oyg.2_Missense_Mutation_p.P93S|SLC25A27_uc011dwc.1_5'UTR|SLC25A27_uc003oyi.2_5'Flank	NM_004277	NP_004268	O95847	UCP4_HUMAN	solute carrier family 25, member 27	93	Solcar 1.|Helical; Name=2; (Potential).				generation of precursor metabolites and energy|transport	integral to membrane|mitochondrial inner membrane					0			Lung(136;0.192)			AGGAGTGACACCCGCCATTTA	0.453		NaN											0	0	0	0.013114	0	35	72									
GSTA5	221357	broad.mit.edu	37	6	52698951	52698951	+	Silent	SNP	A	A	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr6:52698951A>C	uc003pba.1	-	5	472	c.402T>G	c.(400-402)CCT>CCG	p.P134P		NM_153699	NP_714543	Q7RTV2	GSTA5_HUMAN	glutathione S-transferase alpha 5	134	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)	1	Lung NSC(77;0.0912)				Glutathione(DB00143)	TTTCAAAGGCAGGGAAGTAGC	0.423		NaN											0	0	0	0.01441	0	52	92									
MDN1	23195	broad.mit.edu	37	6	90448114	90448114	+	Missense_Mutation	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr6:90448114C>T	uc003pnn.1	-	33	4770	c.4654G>A	c.(4654-4656)GAA>AAA	p.E1552K		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	1552					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		ATTAAATCTTCACGGCTTGTG	0.393		NaN											0	0	0	0.024334	0	25	37									
CLVS2	134829	broad.mit.edu	37	6	123319295	123319295	+	Missense_Mutation	SNP	A	A	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr6:123319295A>T	uc003pzi.1	+	2	1242	c.373A>T	c.(373-375)AAT>TAT	p.N125Y		NM_001010852	NP_001010852	Q5SYC1	CLVS2_HUMAN	retinaldehyde binding protein 1-like 2	125	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						TTTTGCTGCCAATTGGGATCA	0.483		NaN											0	0	0	0.010504	0	19	31									
PHACTR2	9749	broad.mit.edu	37	6	143929448	143929448	+	Missense_Mutation	SNP	T	T	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr6:143929448T>C	uc003qjq.3	+	1	132	c.2T>C	c.(1-3)ATG>ACG	p.M1T	PHACTR2_uc010khh.2_Missense_Mutation_p.M1T	NM_014721	NP_055536	O75167	PHAR2_HUMAN	phosphatase and actin regulator 2 isoform 3	1							actin binding|protein phosphatase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(155;1.58e-05)|GBM - Glioblastoma multiforme(68;0.0386)		TCCTGAGACATGGACAACGCC	0.542		NaN											0	0	0	0.016522	0	18	31									
GRM1	2911	broad.mit.edu	37	6	146720833	146720833	+	Silent	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr6:146720833C>T	uc010khw.1	+	8	3128	c.2658C>T	c.(2656-2658)GCC>GCT	p.A886A	GRM1_uc010khv.1_Silent_p.A886A|GRM1_uc003qll.2_Silent_p.A886A|GRM1_uc011edz.1_Silent_p.A886A|GRM1_uc011eea.1_Silent_p.A886A	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	886	Cytoplasmic (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	CAGGGAATGCCAAGTGAGTTA	0.343		NaN											0	0	0	0.021553	0	6	7									
SYNE1	23345	broad.mit.edu	37	6	152674462	152674462	+	Missense_Mutation	SNP	T	T	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr6:152674462T>A	uc010kiw.2	-	69	11791	c.11189A>T	c.(11188-11190)AAT>ATT	p.N3730I	SYNE1_uc003qot.3_Missense_Mutation_p.N3715I|SYNE1_uc003qou.3_Missense_Mutation_p.N3730I|SYNE1_uc010kja.1_Missense_Mutation_p.N435I	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	3730	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GGTAGCCACATTCTTGAAGTT	0.398		NaN								HNSCC(10;0.0054)			0	0	0	0.014758	0	5	103									
PNLDC1	154197	broad.mit.edu	37	6	160225085	160225085	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr6:160225085C>T	uc003qsx.1	+	5	475	c.304C>T	c.(304-306)CAG>TAG	p.Q102*	PNLDC1_uc003qsy.1_Nonsense_Mutation_p.Q113*	NM_173516	NP_775787	Q8NA58	PNDC1_HUMAN	poly(A)-specific ribonuclease (PARN)-like domain	102	Cytoplasmic (Potential).					integral to membrane|nucleus	nucleic acid binding				0		Breast(66;0.00519)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;1.55e-18)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		TTCCAGTGTTCAGTTTTTGAA	0.343		NaN											0	0	0	0.01441	0	53	107									
CCR6	1235	broad.mit.edu	37	6	167550264	167550264	+	Silent	SNP	T	T	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr6:167550264T>G	uc003qvl.2	+	13	3022	c.546T>G	c.(544-546)ACT>ACG	p.T182T	CCR6_uc010kkm.2_Silent_p.T182T|CCR6_uc003qvn.3_Silent_p.T182T|CCR6_uc003qvm.3_Silent_p.T182T	NM_031409	NP_113597	P51684	CCR6_HUMAN	chemokine (C-C motif) receptor 6	182	Extracellular (Potential).			T -> S (in Ref. 4; AAB06949).	cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|humoral immune response	integral to plasma membrane	C-C chemokine receptor activity			ovary(1)	1		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;8.21e-20)|BRCA - Breast invasive adenocarcinoma(81;4.55e-06)|GBM - Glioblastoma multiforme(31;0.00507)		CCAGCTCAACTTTTGTCTTCA	0.517		NaN											0	0	0	0.021022	0	35	40									
SKAP2	8935	broad.mit.edu	37	7	26709771	26709771	+	Missense_Mutation	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr7:26709771C>T	uc003syc.2	-	12	1321	c.1028G>A	c.(1027-1029)GGA>GAA	p.G343E	SKAP2_uc011jzi.1_Missense_Mutation_p.G171E|SKAP2_uc011jzj.1_Missense_Mutation_p.G328E	NM_003930	NP_003921	O75563	SKAP2_HUMAN	src kinase associated phosphoprotein 2	343	SH3.				B cell activation|cell junction assembly|protein complex assembly|signal transduction	cytosol|plasma membrane	SH3/SH2 adaptor activity			pancreas(1)	1						GCCAATGGCTCCCTTCATTTC	0.363		NaN											0	0	0	0.01892	0	19	28									
HOXA10	3206	broad.mit.edu	37	7	27213894	27213894	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr7:27213894G>A	uc011jzm.1	-	1	62	c.32C>T	c.(31-33)TCG>TTG	p.S11L	HOXA10_uc003syw.3_Intron	NM_018951	NP_061824	P31260	HXA10_HUMAN	homeobox A10 isoform a	11					spermatogenesis		protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						ATAATTTGGCGAAGGGAGCAG	0.557		NaN											0	0	0	0.010771	0	46	86									
SEMA3A	10371	broad.mit.edu	37	7	83636800	83636800	+	Nonsense_Mutation	SNP	C	C	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr7:83636800C>A	uc003uhz.2	-	10	1324	c.1009G>T	c.(1009-1011)GGA>TGA	p.G337*		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	337	Sema.				axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						ACGGCTGATCCCTTGAAAATG	0.388		NaN											1	0	4.7546e-09	0.028581	4.98268e-09	15	19									
ZAN	7455	broad.mit.edu	37	7	100364700	100364700	+	Missense_Mutation	SNP	C	C	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr7:100364700C>A	uc003uwj.2	+	25	4845	c.4680C>A	c.(4678-4680)TTC>TTA	p.F1560L	ZAN_uc003uwk.2_Missense_Mutation_p.F1560L|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kkd.1_Missense_Mutation_p.F137L	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	1560	Extracellular (Potential).|VWFD 2.				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			TGCACCACTTCATGGGCACCT	0.607		NaN											1	0	4.25531e-23	0.01441	4.68414e-23	46	86									
MOGAT3	346606	broad.mit.edu	37	7	100841559	100841559	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr7:100841559G>A	uc003uyc.2	-	5	748	c.581C>T	c.(580-582)GCG>GTG	p.A194V	MOGAT3_uc010lhr.2_Missense_Mutation_p.A194V	NM_178176	NP_835470	Q86VF5	MOGT3_HUMAN	monoacylglycerol O-acyltransferase 3	194					glycerol metabolic process|lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity|diacylglycerol O-acyltransferase activity			ovary(2)	2	Lung NSC(181;0.168)|all_lung(186;0.215)					GGCCTCGTGCGCACCCCCCAC	0.677		NaN											0	0	0	0.01441	0	70	23									
PAX4	5078	broad.mit.edu	37	7	127253582	127253582	+	Missense_Mutation	SNP	G	G	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr7:127253582G>T	uc010lld.1	-	5	749	c.543C>A	c.(541-543)TTC>TTA	p.F181L	PAX4_uc003vmf.2_Missense_Mutation_p.F179L|PAX4_uc003vmg.1_Missense_Mutation_p.F181L|PAX4_uc003vmh.2_Missense_Mutation_p.F179L	NM_006193	NP_006184	O43316	PAX4_HUMAN	paired box 4	189	Homeobox.				cell differentiation|endocrine pancreas development|organ morphogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						GCCCACGCTGGAACTCTGCGG	0.587		NaN											1	0	4.96729e-08	0.008871	5.12986e-08	20	57									
CNTNAP2	26047	broad.mit.edu	37	7	147600709	147600709	+	Silent	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr7:147600709C>T	uc003weu.1	+	14	2667	c.2151C>T	c.(2149-2151)TAC>TAT	p.Y717Y		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	717	Extracellular (Potential).|Fibrinogen C-terminal.				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			AGCACTACTACTGGGGAGGCT	0.512		NaN								HNSCC(39;0.1)			0	0	0	0.004482	0	6	21									
ARHGEF10	9639	broad.mit.edu	37	8	1841803	1841803	+	Silent	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr8:1841803G>A	uc003wpr.2	+	12	1429	c.1251G>A	c.(1249-1251)AGG>AGA	p.R417R	ARHGEF10_uc003wpq.1_Silent_p.R442R|ARHGEF10_uc003wps.2_Silent_p.R379R|ARHGEF10_uc003wpt.2_Silent_p.R293R|ARHGEF10_uc003wpv.2_Silent_p.R150R|ARHGEF10_uc010lre.2_Silent_p.R97R	NM_014629	NP_055444	O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor 10	442	DH.				centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)	1		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		CTCTTAAGAGGATTTTGGAGG	0.313		NaN											0	0	0	0.024245	0	13	42									
LPL	4023	broad.mit.edu	37	8	19811640	19811640	+	Missense_Mutation	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr8:19811640C>T	uc003wzk.3	+	5	921	c.551C>T	c.(550-552)CCA>CTA	p.P184L		NM_000237	NP_000228	P06858	LIPL_HUMAN	lipoprotein lipase precursor	184			P -> R (in LPL deficiency; Nijmegen; loss of activity).		fatty acid biosynthetic process|lipoprotein metabolic process|phospholipid metabolic process|positive regulation of cholesterol storage|positive regulation of sequestering of triglyceride|triglyceride catabolic process|triglyceride homeostasis|very-low-density lipoprotein particle remodeling	anchored to membrane|chylomicron|plasma membrane|very-low-density lipoprotein particle	heparin binding|lipoprotein lipase activity|phospholipase activity|receptor binding|triglyceride lipase activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3				Colorectal(111;0.0577)|COAD - Colon adenocarcinoma(73;0.216)	Clofibrate(DB00636)|Gemfibrozil(DB01241)|Orlistat(DB01083)	GGCCTCGATCCAGCTGGACCT	0.453		NaN											0	0	0	0.008871	0	19	55									
CDCA2	157313	broad.mit.edu	37	8	25364307	25364307	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr8:25364307G>A	uc003xep.1	+	15	2604	c.2125G>A	c.(2125-2127)GAC>AAC	p.D709N	PPP2R2A_uc003xek.2_Intron|CDCA2_uc011lae.1_3'UTR|CDCA2_uc003xeq.1_Missense_Mutation_p.D694N|CDCA2_uc003xer.1_Missense_Mutation_p.D372N	NM_152562	NP_689775	Q69YH5	CDCA2_HUMAN	cell division cycle associated 2	709					cell division|mitosis	cytoplasm|nucleus					0		all_cancers(63;0.0378)|Ovarian(32;0.000878)|all_epithelial(46;0.0162)|Breast(100;0.0164)|Prostate(55;0.191)		UCEC - Uterine corpus endometrioid carcinoma (27;0.022)|Epithelial(17;1.37e-11)|Colorectal(74;0.0129)|COAD - Colon adenocarcinoma(73;0.0443)		AGCTGGAACTGACAGTCCTGT	0.373		NaN											0	0	0	0.00308	0	6	12									
DUSP26	78986	broad.mit.edu	37	8	33451114	33451114	+	Missense_Mutation	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr8:33451114C>T	uc003xjp.2	-	3	706	c.373G>A	c.(373-375)GAC>AAC	p.D125N	DUSP26_uc003xjq.2_Missense_Mutation_p.D125N	NM_024025	NP_076930	Q9BV47	DUS26_HUMAN	dual specificity phosphatase 26	125	Tyrosine-protein phosphatase.					Golgi apparatus|nucleus	protein binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0				KIRC - Kidney renal clear cell carcinoma(67;0.0918)|Kidney(114;0.111)		ATGCTCATGTCAAAGGCTGGC	0.642		NaN											0	0	0	0.007835	0	32	94									
RP1	6101	broad.mit.edu	37	8	55539332	55539332	+	Missense_Mutation	SNP	A	A	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr8:55539332A>G	uc003xsd.1	+	4	3038	c.2890A>G	c.(2890-2892)ATA>GTA	p.I964V	RP1_uc011ldy.1_Intron	NM_006269	NP_006260	P56715	RP1_HUMAN	retinitis pigmentosa RP1 protein	964					axoneme assembly|intracellular signal transduction|photoreceptor cell maintenance|photoreceptor cell outer segment organization|phototransduction, visible light|retinal cone cell development|retinal rod cell development	cilium axoneme|cytoplasm|microtubule|microtubule associated complex|photoreceptor connecting cilium|photoreceptor inner segment|photoreceptor outer segment	microtubule binding			skin(7)|ovary(4)|pancreas(1)	12		all_lung(136;0.0831)|Lung NSC(129;0.109)|all_epithelial(80;0.123)	OV - Ovarian serous cystadenocarcinoma(7;4.4e-07)|Epithelial(17;3.37e-05)|all cancers(17;0.000285)			TTCTGGAAAAATAAGTAATTT	0.328		NaN											0	0	0	0.007291	0	29	22									
PLAG1	5324	broad.mit.edu	37	8	57079893	57079893	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr8:57079893G>A	uc003xsq.3	-	3	863	c.412C>T	c.(412-414)CGT>TGT	p.R138C	PLAG1_uc003xsr.3_Missense_Mutation_p.R138C|PLAG1_uc010lyi.2_Missense_Mutation_p.R138C|PLAG1_uc010lyj.2_Missense_Mutation_p.R56C	NM_001114635	NP_001108107	Q6DJT9	PLAG1_HUMAN	pleiomorphic adenoma gene 1 isoform b	138	Decreased nuclear import with localization in the nucleus but also in the cytoplasm.|C2H2-type 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding		CTNNB1/PLAG1(60)|FGFR1_ENST00000447712/PLAG1(28)|CHCHD7/PLAG1(12)|LIFR_ENST00000263409/PLAG1(10)|HAS2/PLAG1(10)|COL1A2/PLAG1(3)|TCEA1_ENST00000521604/PLAG1(3)	salivary_gland(113)|soft_tissue(13)|lung(1)|central_nervous_system(1)|breast(1)	129		all_lung(136;0.0548)|Lung NSC(129;0.0718)|all_epithelial(80;0.125)	Epithelial(17;0.00179)|all cancers(17;0.0125)			GCCAAGTGACGTTTAAATCCA	0.448		NaN	T	TCEA1|LIFR|CTNNB1|CHCHD7	salivary adenoma								0	0	0	0.010729	0	9	30									
ZFHX4	79776	broad.mit.edu	37	8	77764201	77764201	+	Missense_Mutation	SNP	C	C	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr8:77764201C>G	uc003yav.2	+	10	5296	c.4909C>G	c.(4909-4911)CAA>GAA	p.Q1637E	ZFHX4_uc003yau.1_Missense_Mutation_p.Q1682E|ZFHX4_uc003yaw.1_Missense_Mutation_p.Q1637E	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1637						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			AATCTCTGCTCAACCTGCACA	0.403		NaN								HNSCC(33;0.089)			0	0	0	0.008291	0	11	43									
PLEKHF2	79666	broad.mit.edu	37	8	96166422	96166422	+	Silent	SNP	C	C	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr8:96166422C>G	uc003yhn.1	+	2	397	c.150C>G	c.(148-150)CCC>CCG	p.P50P		NM_024613	NP_078889	Q9H8W4	PKHF2_HUMAN	phafin 2	50	PH.					transport vesicle	metal ion binding|protein binding			ovary(2)	2	Breast(36;3.18e-05)					GGAAAAAGCCCAAAGCAAGGC	0.358		NaN											0	0	0	0.007413	0	17	63									
GDF6	392255	broad.mit.edu	37	8	97157377	97157377	+	Missense_Mutation	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr8:97157377C>T	uc003yhp.2	-	2	882	c.782G>A	c.(781-783)CGG>CAG	p.R261Q		NM_001001557	NP_001001557	Q6KF10	GDF6_HUMAN	growth differentiation factor 6 precursor	261					activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(1)|breast(1)|pancreas(1)	3	Breast(36;2.67e-05)					GCCCAGACTCCGCAGGTCCGG	0.736		NaN											0	0	0	0.009096	0	3	16									
GDF6	392255	broad.mit.edu	37	8	97172829	97172829	+	Missense_Mutation	SNP	G	G	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr8:97172829G>C	uc003yhp.2	-	1	192	c.92C>G	c.(91-93)TCC>TGC	p.S31C		NM_001001557	NP_001001557	Q6KF10	GDF6_HUMAN	growth differentiation factor 6 precursor	31	Poly-Ser.				activin receptor signaling pathway|BMP signaling pathway|growth|pathway-restricted SMAD protein phosphorylation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent	extracellular space	cytokine activity|growth factor activity			ovary(1)|breast(1)|pancreas(1)	3	Breast(36;2.67e-05)					GGACGACGAGGAGGATGAGAT	0.647		NaN											0	0	0	0.01441	0	49	155									
SYBU	55638	broad.mit.edu	37	8	110588178	110588178	+	Missense_Mutation	SNP	C	C	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr8:110588178C>G	uc003ynj.3	-	7	1112	c.949G>C	c.(949-951)GAG>CAG	p.E317Q	SYBU_uc003yni.3_Missense_Mutation_p.E314Q|SYBU_uc003ynk.3_Missense_Mutation_p.E198Q|SYBU_uc010mco.2_Missense_Mutation_p.E316Q|SYBU_uc003ynl.3_Missense_Mutation_p.E316Q|SYBU_uc010mcp.2_Missense_Mutation_p.E317Q|SYBU_uc010mcq.2_Missense_Mutation_p.E317Q|SYBU_uc003yno.3_Missense_Mutation_p.E198Q|SYBU_uc010mcr.2_Missense_Mutation_p.E317Q|SYBU_uc003ynm.3_Missense_Mutation_p.E316Q|SYBU_uc003ynn.3_Missense_Mutation_p.E316Q|SYBU_uc010mcs.2_Missense_Mutation_p.E198Q|SYBU_uc010mct.2_Missense_Mutation_p.E317Q|SYBU_uc010mcu.2_Missense_Mutation_p.E316Q|SYBU_uc003ynp.3_Missense_Mutation_p.E249Q|SYBU_uc010mcv.2_Missense_Mutation_p.E317Q|SYBU_uc003ynh.3_Missense_Mutation_p.E111Q|SYBU_uc011lhw.1_Missense_Mutation_p.E187Q	NM_001099754	NP_001093224	Q9NX95	SYBU_HUMAN	Golgi-localized syntaphilin-related protein	317	Sufficient for interaction with STX1A.|Potential.|Sufficient for interaction with KIF5B.					cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				ovary(1)	1						CGGTGACACTCCTCCTCAATC	0.502		NaN											0	0	0	0.024334	0	26	73									
CSMD3	114788	broad.mit.edu	37	8	113318249	113318249	+	Silent	SNP	G	G	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr8:113318249G>T	uc003ynu.2	-	51	8217	c.8058C>A	c.(8056-8058)ACC>ACA	p.T2686T	CSMD3_uc003yns.2_Silent_p.T1888T|CSMD3_uc003ynt.2_Silent_p.T2646T|CSMD3_uc011lhx.1_Silent_p.T2582T	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2686	Extracellular (Potential).|Sushi 15.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CACAGCGAGGGGTCTTGTTAT	0.343		NaN								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			1	0	1.08114e-33	0.01441	1.21361e-33	38	109									
PLEC	5339	broad.mit.edu	37	8	145049425	145049425	+	Missense_Mutation	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr8:145049425C>T	uc003zaj.2	-	2	162	c.113G>A	c.(112-114)CGG>CAG	p.R38Q	PLEC_uc003zah.2_5'Flank	NM_000445	NP_000436	Q15149	PLEC_HUMAN	plectin isoform 1c	141	Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						GCGCCGGCTCCGCTGCGTTTT	0.667		NaN									OREG0019050	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.01441	0	84	73									
PTPRD	5789	broad.mit.edu	37	9	8460469	8460469	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr9:8460469G>A	uc003zkk.2	-	32	4528	c.3817C>T	c.(3817-3819)CCT>TCT	p.P1273S	PTPRD_uc003zkp.2_Missense_Mutation_p.P862S|PTPRD_uc003zkq.2_Missense_Mutation_p.P862S|PTPRD_uc003zkr.2_Missense_Mutation_p.P857S|PTPRD_uc003zks.2_Missense_Mutation_p.P852S|PTPRD_uc003zkl.2_Missense_Mutation_p.P1264S|PTPRD_uc003zkm.2_Missense_Mutation_p.P1260S|PTPRD_uc003zkn.2_Missense_Mutation_p.P862S|PTPRD_uc003zko.2_Missense_Mutation_p.P859S	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1273	Helical; (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		GCAAGGACAGGACCTACAACC	0.463		NaN								TSP Lung(15;0.13)			0	0	0	0.009718	0	39	42									
PTPRD	5789	broad.mit.edu	37	9	8465602	8465602	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr9:8465602G>A	uc003zkk.2	-	31	4289	c.3578C>T	c.(3577-3579)GCC>GTC	p.A1193V	PTPRD_uc003zkp.2_Missense_Mutation_p.A782V|PTPRD_uc003zkq.2_Missense_Mutation_p.A782V|PTPRD_uc003zkr.2_Missense_Mutation_p.A777V|PTPRD_uc003zks.2_Missense_Mutation_p.A772V|PTPRD_uc003zkl.2_Missense_Mutation_p.A1184V|PTPRD_uc003zkm.2_Missense_Mutation_p.A1180V|PTPRD_uc003zkn.2_Missense_Mutation_p.A782V|PTPRD_uc003zko.2_Missense_Mutation_p.A779V	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	1193	Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		AAAGTGAGCGGCAATATATGG	0.428		NaN								TSP Lung(15;0.13)			0	0	0	0.009535	0	28	79									
FREM1	158326	broad.mit.edu	37	9	14859231	14859231	+	Missense_Mutation	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr9:14859231C>T	uc003zlm.2	-	4	1171	c.581G>A	c.(580-582)CGA>CAA	p.R194Q	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	194					cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		TTCTTCTGGTCGAGGCTCCCC	0.502		NaN											0	0	0	0.013726	0	31	41									
MLLT3	4300	broad.mit.edu	37	9	20414153	20414153	+	Missense_Mutation	SNP	C	C	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr9:20414153C>G	uc003zoe.2	-	5	950	c.691G>C	c.(691-693)GAA>CAA	p.E231Q	MLLT3_uc011lne.1_Missense_Mutation_p.E199Q|MLLT3_uc011lnf.1_Missense_Mutation_p.E228Q|MLLT3_uc003zof.2_Missense_Mutation_p.E32Q	NM_004529	NP_004520	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	231					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		TTAGAGGATTCTTTGGAAGAT	0.378		NaN	T	MLL	ALL								0	0	0	0.01441	0	40	129									
APTX	54840	broad.mit.edu	37	9	32986023	32986023	+	Silent	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr9:32986023G>A	uc003zrm.2	-	4	686	c.489C>T	c.(487-489)TCC>TCT	p.S163S	APTX_uc010mjm.2_RNA|APTX_uc003zrj.2_Silent_p.S75S|APTX_uc011lns.1_5'UTR|APTX_uc003zrl.2_5'UTR|APTX_uc003zrn.2_Silent_p.S75S|APTX_uc003zro.2_Silent_p.S163S|APTX_uc003zrp.2_Silent_p.S75S|APTX_uc003zrq.2_Silent_p.S75S|APTX_uc003zrr.2_Silent_p.S109S|APTX_uc003zrs.2_Silent_p.S163S|APTX_uc003zrt.2_Silent_p.S75S|APTX_uc003zru.2_Silent_p.S109S|APTX_uc003zrv.2_Silent_p.S177S|APTX_uc003zrw.2_Silent_p.S91S|APTX_uc003zrx.2_Silent_p.S163S|APTX_uc003zry.2_Silent_p.S163S|APTX_uc003zrz.2_5'UTR|APTX_uc003zsa.1_Silent_p.S109S|APTX_uc003zsb.1_RNA|APTX_uc003zsc.1_RNA	NM_175072	NP_778242	Q7Z2E3	APTX_HUMAN	aprataxin isoform c	177					cell death|double-strand break repair|regulation of protein stability|response to hydrogen peroxide|single strand break repair	chromatin|nucleolus|nucleoplasm	chromatin binding|damaged DNA binding|DNA 5'-adenosine monophosphate hydrolase activity|double-stranded DNA binding|double-stranded RNA binding|phosphoglycolate phosphatase activity|phosphoprotein binding|polynucleotide 3'-phosphatase activity|protein N-terminus binding|zinc ion binding			ovary(1)	1			LUSC - Lung squamous cell carcinoma(29;0.0302)	GBM - Glioblastoma multiforme(74;0.105)		AGTGGCCCAGGGATTCCTaaa	0.299		NaN						Direct_reversal_of_damage|Editing_and_processing_nucleases					0	0	0	0.008291	0	10	44									
FAM75A6	389730	broad.mit.edu	37	9	43626815	43626815	+	Silent	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr9:43626815G>A	uc011lrb.1	-	4	1901	c.1872C>T	c.(1870-1872)GAC>GAT	p.D624D		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	624						integral to membrane					0						CTGGTGATTCGTCCCGAAGCT	0.547		NaN											0	0	0	0.006214	0	5	23									
OR1L3	26735	broad.mit.edu	37	9	125438220	125438220	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr9:125438220G>A	uc011lzb.1	+	1	812	c.812G>A	c.(811-813)CGA>CAA	p.R271Q		NM_001005234	NP_001005234	Q8NH93	OR1L3_HUMAN	olfactory receptor, family 1, subfamily L,	271	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1						GTCAAGGACCGAATAGCAACA	0.408		NaN											0	0	0	0.006214	0	8	21									
RPL12	6136	broad.mit.edu	37	9	130210620	130210620	+	Silent	SNP	G	G	C			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr9:130210620G>C	uc004bqy.1	-	5	463	c.375C>G	c.(373-375)CTC>CTG	p.L125L	RPL12_uc004bqx.1_RNA|RPL12_uc004bqz.1_Silent_p.L92L	NM_000976	NP_000967	P30050	RL12_HUMAN	ribosomal protein L12	125					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome				0						TCTTACCAGAGAGTTCTCTGG	0.443		NaN											0	0	0	0.01441	0	80	143									
STXBP1	6812	broad.mit.edu	37	9	130422312	130422312	+	Missense_Mutation	SNP	G	G	A	rs34830702	byFrequency	TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr9:130422312G>A	uc004brl.2	+	5	447	c.250G>A	c.(250-252)GTC>ATC	p.V84I	STXBP1_uc004brk.2_Missense_Mutation_p.V84I	NM_001032221	NP_001027392	P61764	STXB1_HUMAN	syntaxin binding protein 1 isoform b	84			V -> D (in EIEE4; may alter protein structure).		axon target recognition|energy reserve metabolic process|glutamate secretion|negative regulation of synaptic transmission, GABAergic|neurotransmitter secretion|platelet aggregation|platelet degranulation|protein transport|regulation of insulin secretion|regulation of synaptic vesicle priming|synaptic vesicle maturation|vesicle docking involved in exocytosis	cytosol|mitochondrion|plasma membrane|platelet alpha granule|protein complex	identical protein binding|syntaxin-1 binding|syntaxin-2 binding			skin(1)	1						TCCACAGTCCGTCCACTCTCT	0.507		NaN											0	0	0	0.01892	0	20	51									
SPTAN1	6709	broad.mit.edu	37	9	131388155	131388155	+	Silent	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr9:131388155C>T	uc004bvl.3	+	47	6275	c.6162C>T	c.(6160-6162)ATC>ATT	p.I2054I	SPTAN1_uc004bvm.3_Silent_p.I2059I|SPTAN1_uc004bvn.3_Silent_p.I2034I|SPTAN1_uc010mye.1_5'Flank|SPTAN1_uc010myf.1_5'Flank	NM_003127	NP_003118	Q13813	SPTA2_HUMAN	spectrin, alpha, non-erythrocytic 1	2054	Spectrin 21.				actin filament capping|axon guidance|cellular component disassembly involved in apoptosis	cytosol|intracellular membrane-bounded organelle|membrane fraction|microtubule cytoskeleton|spectrin	actin binding|calcium ion binding|calmodulin binding|structural constituent of cytoskeleton			breast(5)|ovary(4)|pancreas(1)	10						CCAAGGCCATCGAGGCCCGGC	0.602		NaN											0	0	0	0.01441	0	73	132									
COL5A1	1289	broad.mit.edu	37	9	137709646	137709646	+	Missense_Mutation	SNP	C	C	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr9:137709646C>A	uc004cfe.2	+	54	4581	c.4199C>A	c.(4198-4200)CCC>CAC	p.P1400H		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1400	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		CCCGCAGGCCCCGAAGGCAGA	0.662		NaN											1	0	2.80697e-09	0.010729	2.95252e-09	9	5									
COL5A1	1289	broad.mit.edu	37	9	137717708	137717708	+	Silent	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr9:137717708C>T	uc004cfe.2	+	63	5407	c.5025C>T	c.(5023-5025)GCC>GCT	p.A1675A	uc004cff.2_Intron	NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1675	Fibrillar collagen NC1.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		ACTTCACAGCCGGGGGGTCGA	0.592		NaN											0	0	0	0.015359	0	29	61									
COL5A1	1289	broad.mit.edu	37	9	137734025	137734025	+	Missense_Mutation	SNP	C	C	T			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr9:137734025C>T	uc004cfe.2	+	66	5775	c.5393C>T	c.(5392-5394)ACG>ATG	p.T1798M	uc004cff.2_Intron	NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	1798	Fibrillar collagen NC1.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		TACCAGAAGACGGTTCTGGAG	0.522		NaN											0	0	0	0.013537	0	10	59									
EGFL7	51162	broad.mit.edu	37	9	139565433	139565433	+	Silent	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr9:139565433G>A	uc004cid.2	+	8	1514	c.603G>A	c.(601-603)CAG>CAA	p.Q201Q	EGFL7_uc004cif.2_Silent_p.Q201Q|EGFL7_uc004cig.2_RNA|EGFL7_uc010nbp.2_Silent_p.Q201Q|EGFL7_uc004cie.2_Silent_p.Q201Q|EGFL7_uc004cih.2_Silent_p.Q201Q	NM_201446	NP_958854	Q9UHF1	EGFL7_HUMAN	EGF-like-domain, multiple 7	201	Potential.				angiogenesis|vasculogenesis		calcium ion binding			ovary(1)	1	all_cancers(76;0.109)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.87e-06)|Epithelial(140;0.000123)		AAGAAGTGCAGAGGCTGCAGT	0.697		NaN											0	0	0	0.014758	0	4	5									
HUWE1	10075	broad.mit.edu	37	X	53672365	53672365	+	Silent	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chrX:53672365G>A	uc004dsp.2	-	7	804	c.402C>T	c.(400-402)GTC>GTT	p.V134V		NM_031407	NP_113584	Q7Z6Z7	HUWE1_HUMAN	HECT, UBA and WWE domain containing 1	134					base-excision repair|cell differentiation|histone ubiquitination|protein monoubiquitination|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	DNA binding|protein binding|ubiquitin-protein ligase activity			ovary(8)|large_intestine(4)|breast(4)|kidney(1)	17						GGAGATTGAGGACTGCCAGCA	0.458		NaN											0	0	0	0.008871	0	17	8									
TAZ	6901	broad.mit.edu	37	X	153648555	153648555	+	Missense_Mutation	SNP	G	G	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chrX:153648555G>A	uc004fkx.2	+	9	955	c.651G>A	c.(649-651)ATG>ATA	p.M217I	TAZ_uc004fky.2_Missense_Mutation_p.M203I|TAZ_uc004fkz.2_RNA|TAZ_uc004fla.2_Missense_Mutation_p.M187I|TAZ_uc004flb.2_Missense_Mutation_p.M173I|TAZ_uc010nuy.2_Missense_Mutation_p.M221I|TAZ_uc004flc.3_Missense_Mutation_p.M187I	NM_000116	NP_000107	Q16635	TAZ_HUMAN	tafazzin isoform 1	217					cardiac muscle contraction|cardiac muscle tissue development|cardiolipin biosynthetic process|cristae formation|hemopoiesis|mitochondrial ATP synthesis coupled electron transport|mitochondrial respiratory chain complex I assembly|skeletal muscle tissue development	integral to membrane|mitochondrion	1-acylglycerophosphocholine O-acyltransferase activity				0	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTGCAGGAATGAATGACGTCC	0.637		NaN											0	0	0	0.01441	0	186	52									
CD1D	912	broad.mit.edu	37	1	158151257	158151257	+	Frame_Shift_Del	DEL	T	T	-			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr1:158151257delT	uc001frr.2	+	3	573	c.74delT	c.(73-75)CTTfs	p.L25fs	CD1D_uc009wsr.1_Frame_Shift_Del_p.L25fs|CD1D_uc009wss.2_Frame_Shift_Del_p.L25fs|CD1D_uc009wst.1_Intron	NM_001766	NP_001757	P15813	CD1D_HUMAN	CD1D antigen precursor	25	Extracellular (Potential).				antigen processing and presentation, endogenous lipid antigen via MHC class Ib|detection of bacterium|innate immune response|interspecies interaction between organisms|positive regulation of innate immune response|T cell selection	endosome membrane|integral to plasma membrane|lysosomal membrane	beta-2-microglobulin binding|exogenous lipid antigen binding|histone binding			ovary(1)	1	all_hematologic(112;0.0378)					CCGCAAAGGCTTTTCCCCCTC	0.592		NaN											NaN	NaN	NaN	NaN	NaN	7	868	---	---							
LRFN4	78999	broad.mit.edu	37	11	66627383	66627383	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr11:66627383delG	uc001ojr.2	+	2	1965	c.1625delG	c.(1624-1626)CGGfs	p.R542fs	PC_uc001ojo.1_Intron|PC_uc001ojp.1_Intron|PC_uc001ojn.1_Intron|LRFN4_uc001ojs.2_Intron	NM_024036	NP_076941	Q6PJG9	LRFN4_HUMAN	leucine rich repeat and fibronectin type III	542	Cytoplasmic (Potential).					integral to membrane					0						GTTCGGGGCCGGGGGGCCGGA	0.657		NaN											NaN	NaN	NaN	NaN	NaN	21	58	---	---							
PLEKHG6	55200	broad.mit.edu	37	12	6436757	6436759	+	In_Frame_Del	DEL	GAA	GAA	-			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr12:6436757_6436759delGAA	uc001qnr.2	+	15	2156_2158	c.2008_2010delGAA	c.(2008-2010)GAAdel	p.E671del	PLEKHG6_uc010sew.1_In_Frame_Del_p.E671del|PLEKHG6_uc010sex.1_In_Frame_Del_p.E639del	NM_018173	NP_060643	Q3KR16	PKHG6_HUMAN	pleckstrin homology domain-containing family G	671					regulation of Rho protein signal transduction	cleavage furrow|cytoplasm|spindle pole	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			large_intestine(1)|skin(1)	2						CTGGTCTGAGGAAGAAGATGGGG	0.631		NaN											NaN	NaN	NaN	NaN	NaN	5	6	---	---							
CDKN1B	1027	broad.mit.edu	37	12	12871015	12871016	+	Frame_Shift_Ins	INS	-	-	TTCT			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr12:12871015_12871016insTTCT	uc001rat.2	+	1	714_715	c.242_243insTTCT	c.(241-243)AAGfs	p.K81fs		NM_004064	NP_004055	P46527	CDN1B_HUMAN	cyclin-dependent kinase inhibitor 1B	81					autophagic cell death|cell cycle arrest|cellular response to lithium ion|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of transcription, DNA-dependent|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of protein catabolic process|S phase of mitotic cell cycle	cytosol|endosome|nucleoplasm	cyclin-dependent protein kinase inhibitor activity|protein phosphatase binding|transforming growth factor beta receptor, cytoplasmic mediator activity			ovary(1)|lung(1)	2		Prostate(47;0.0322)|all_epithelial(100;0.159)		BRCA - Breast invasive adenocarcinoma(232;0.0336)		GAGGTGGAGAAGGGCAGCTTGC	0.614		NaN							Multiple_Endocrine_Neoplasia_type_1|Multiple_Endocrine_Neoplasia_type_4				NaN	NaN	NaN	NaN	NaN	72	103	---	---							
IL31	386653	broad.mit.edu	37	12	122658748	122658748	+	Splice_Site	DEL	G	G	-			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr12:122658748delG	uc001ubv.2	-	1	1	c.-26_splice	c.e1-1		LRRC43_uc001ubw.3_Intron|LRRC43_uc009zxl.1_Intron	NM_001014336	NP_001014358	Q6EBC2	IL31_HUMAN	interleukin 31 precursor							extracellular space	cytokine activity			central_nervous_system(1)	1	all_neural(191;0.0837)|Medulloblastoma(191;0.163)	Lung NSC(355;6.93e-05)|Breast(359;0.0544)		OV - Ovarian serous cystadenocarcinoma(86;3.27e-29)|Epithelial(86;4.86e-27)|BRCA - Breast invasive adenocarcinoma(302;0.223)		CAGCTTCAGTGGGGGCTTCTG	0.572		NaN											NaN	NaN	NaN	NaN	NaN	33	48	---	---							
ARHGEF15	22899	broad.mit.edu	37	17	8222137	8222138	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:8222137_8222138insG	uc002glc.2	+	12	2063_2064	c.1942_1943insG	c.(1942-1944)AGGfs	p.R648fs	ARHGEF15_uc002gld.2_Frame_Shift_Ins_p.R648fs|ARHGEF15_uc010vuw.1_Frame_Shift_Ins_p.R537fs	NM_173728	NP_776089	O94989	ARHGF_HUMAN	Rho guanine exchange factor 15	648					negative regulation of synapse maturation|regulation of Rho protein signal transduction	dendrite|intracellular	GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(2)|skin(1)	3						AGGGTGCCGGAGGGGGGGCGTG	0.634		NaN											NaN	NaN	NaN	NaN	NaN	7	812	---	---							
CCDC103	388389	broad.mit.edu	37	17	42980014	42980015	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:42980014_42980015delAG	uc002iho.2	+	4	641_642	c.558_559delAG	c.(556-561)GCAGAGfs	p.A186fs	CCDC103_uc002ihp.1_5'Flank	NM_213607	NP_998772	Q8IW40	CC103_HUMAN	coiled-coil domain containing 103	186_187										kidney(1)	1		Prostate(33;0.109)				TGAGCCGGGCAGAGAGAGAGAG	0.644		NaN											NaN	NaN	NaN	NaN	NaN	11	116	---	---							
SRP68	6730	broad.mit.edu	37	17	74068528	74068530	+	In_Frame_Del	DEL	GCC	GCC	-			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr17:74068528_74068530delGCC	uc002jqk.1	-	1	78_80	c.43_45delGGC	c.(43-45)GGCdel	p.G15del	SRP68_uc010wsu.1_5'UTR|SRP68_uc002jql.1_In_Frame_Del_p.G15del|GALR2_uc002jqm.1_5'Flank	NM_014230	NP_055045	Q9UHB9	SRP68_HUMAN	signal recognition particle 68kDa	15	Poly-Gly.			Missing (in Ref. 1).	response to drug	cytosol|endoplasmic reticulum|nucleolus|ribosome|signal recognition particle, endoplasmic reticulum targeting	RNA binding|signal recognition particle binding			ovary(1)	1						cgccgccactgccgccgccgccg	0.429		NaN											NaN	NaN	NaN	NaN	NaN	8	118	---	---							
KIAA1683	80726	broad.mit.edu	37	19	18378205	18378206	+	Frame_Shift_Del	DEL	TC	TC	-			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:18378205_18378206delTC	uc002nin.2	-	3	360_361	c.144_145delGA	c.(142-147)GAGAAAfs	p.E48fs	KIAA1683_uc010ebn.2_Frame_Shift_Del_p.E48fs|KIAA1683_uc010xqe.1_Frame_Shift_Del_p.E2fs	NM_025249	NP_079525	Q9H0B3	K1683_HUMAN	KIAA1683 isoform b	48_49						mitochondrion				ovary(2)	2						GGAGGCGCTTTCTCCATTTTGT	0.653		NaN											NaN	NaN	NaN	NaN	NaN	64	163	---	---							
SPTBN4	57731	broad.mit.edu	37	19	41076449	41076450	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BL-A3JM-01A-12D-A21A-08	TCGA-BL-A3JM-11A-31D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	b181ba68-f50f-4faf-b7b5-356e119b5f04	6f399153-4bf7-482b-9657-331028dd9a37	g.chr19:41076449_41076450insA	uc002ony.2	+	33	7220_7221	c.7134_7135insA	c.(7132-7137)CCCAAGfs	p.P2378fs	SPTBN4_uc002onz.2_Frame_Shift_Ins_p.P2378fs|SPTBN4_uc010egx.2_Frame_Shift_Ins_p.P1121fs	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	2378_2379					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			gggaccggcccaagccgcgacg	0.332		NaN											NaN	NaN	NaN	NaN	NaN	6	9	---	---							
