Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
TAS1R3	83756	broad.mit.edu	37	1	1268918	1268918	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr1:1268918G>T	uc010nyk.1	+	6	1633	c.1633G>T	c.(1633-1635)GAG>TAG	p.E545*		NM_152228	NP_689414	Q7RTX0	TS1R3_HUMAN	taste receptor, type 1, member 3 precursor	545	Extracellular (Potential).|Required for brazzein responsiveness.				detection of chemical stimulus involved in sensory perception of sweet taste|sensory perception of umami taste	plasma membrane	protein heterodimerization activity|taste receptor activity				0	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;3.01e-35)|OV - Ovarian serous cystadenocarcinoma(86;3.88e-21)|Colorectal(212;0.000157)|COAD - Colon adenocarcinoma(227;0.000193)|Kidney(185;0.00229)|BRCA - Breast invasive adenocarcinoma(365;0.00251)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.034)|Lung(427;0.146)	Aspartame(DB00168)	TGGCCAGGATGAGTGGTCCCC	0.637		NaN											1	0	1.88708e-17	0.008361	2.09522e-17	22	60									
CD164L2	388611	broad.mit.edu	37	1	27706644	27706644	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr1:27706644C>T	uc001boc.2	-	5	491	c.415G>A	c.(415-417)GGG>AGG	p.G139R		NM_207397	NP_997280	Q6UWJ8	C16L2_HUMAN	CD164 sialomucin-like 2	139	Extracellular (Potential).					integral to membrane					0		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;2.89e-26)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00128)|KIRC - Kidney renal clear cell carcinoma(1967;0.00155)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		AAGCTGGCCCCGTCAAATCCA	0.617		NaN											0	0	0	0.00308	0	5	93									
FOXD2	2306	broad.mit.edu	37	1	47904409	47904409	+	Nonsense_Mutation	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr1:47904409G>A	uc001crm.2	+	1	2721	c.602G>A	c.(601-603)TGG>TAG	p.W201*		NM_004474	NP_004465	O60548	FOXD2_HUMAN	forkhead box D2	201	Fork-head.				axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0				READ - Rectum adenocarcinoma(2;0.0908)		GGCAACTACTGGACGCTGGAC	0.672		NaN											0	0	0	0.01441	0	53	131									
CRNN	49860	broad.mit.edu	37	1	152382699	152382700	+	Missense_Mutation	DNP	CA	CA	TG			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr1:152382699_152382700CA>TG	uc001ezx.2	-	3	932_933	c.858_859TG>CA	c.(856-861)CATGCT>CACACT	p.A287T		NM_016190	NP_057274	Q9UBG3	CRNN_HUMAN	cornulin	287	Gln-rich.				cell-cell adhesion|response to heat	cytoplasm|membrane	calcium ion binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGTATCTGAGCATGTCCTCCTG	0.614		NaN											0	0	0	0.004672	0	7	508									
PYGO2	90780	broad.mit.edu	37	1	154933468	154933468	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr1:154933468C>A	uc001fft.2	-	2	344	c.138G>T	c.(136-138)AGG>AGT	p.R46S		NM_138300	NP_612157	Q9BRQ0	PYGO2_HUMAN	pygopus homolog 2	46	Nuclear localization signal (Potential).|Pro-rich.				Wnt receptor signaling pathway	nucleus	protein binding|zinc ion binding			skin(1)	1	all_epithelial(22;4.9e-30)|all_lung(78;4.1e-28)|all_hematologic(923;0.0359)|Hepatocellular(266;0.0877)|all_neural(408;0.245)		BRCA - Breast invasive adenocarcinoma(34;0.00034)			TATTTGACTTCCTTCGCTTCT	0.502		NaN											1	0	6.40141e-05	0.010729	6.80713e-05	8	436									
PIGC	5279	broad.mit.edu	37	1	172410941	172410941	+	Silent	SNP	A	A	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr1:172410941A>G	uc001gil.2	-	2	1103	c.822T>C	c.(820-822)CTT>CTC	p.L274L	PIGC_uc001gii.1_Intron|PIGC_uc001gij.1_Intron|C1orf105_uc001gik.2_Intron|PIGC_uc001gin.2_Silent_p.L274L|PIGC_uc001gio.2_Silent_p.L274L	NM_153747	NP_714969	Q92535	PIGC_HUMAN	phosphatidylinositol glycan, class C	274					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex|integral to membrane	phosphatidylinositol N-acetylglucosaminyltransferase activity			lung(1)	1						TTTCTTTAAAAAGCTGCAAGC	0.438		NaN											0	0	0	0.006122	0	17	57									
ASPM	259266	broad.mit.edu	37	1	197059202	197059202	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr1:197059202C>T	uc001gtu.2	-	25	10099	c.9842G>A	c.(9841-9843)AGA>AAA	p.R3281K	ASPM_uc001gtv.2_Missense_Mutation_p.R1696K|ASPM_uc001gtw.3_Missense_Mutation_p.R1129K	NM_018136	NP_060606	Q8IZT6	ASPM_HUMAN	asp (abnormal spindle)-like, microcephaly	3281					mitosis	cytoplasm|nucleus	calmodulin binding			ovary(4)|central_nervous_system(2)	6						TGGAGACAATCTAGTAACTAC	0.333		NaN											0	0	0	0.006122	0	14	37									
PPFIA4	8497	broad.mit.edu	37	1	203025554	203025554	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr1:203025554G>A	uc001gyz.2	+	5	1233	c.640G>A	c.(640-642)GAG>AAG	p.E214K	PPFIA4_uc009xaj.2_Missense_Mutation_p.E845K|PPFIA4_uc010pqf.1_Missense_Mutation_p.E427K|PPFIA4_uc001gza.2_Missense_Mutation_p.E214K|PPFIA4_uc001gzb.1_5'Flank	NM_015053	NP_055868	O75335	LIPA4_HUMAN	protein tyrosine phosphatase, receptor type, f	214					cell communication	cell surface|cytoplasm	protein binding			ovary(4)|skin(1)	5						CATAAAATGTGAGACTTCTCC	0.577		NaN											0	0	0	0.010729	0	9	51									
NFASC	23114	broad.mit.edu	37	1	204951129	204951129	+	Silent	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr1:204951129C>T	uc001hbj.2	+	21	2779	c.2451C>T	c.(2449-2451)ATC>ATT	p.I817I	NFASC_uc010pra.1_Silent_p.I813I|NFASC_uc001hbi.2_Silent_p.I813I|NFASC_uc010prb.1_Silent_p.I828I|NFASC_uc010prc.1_Silent_p.I384I|NFASC_uc001hbk.1_Silent_p.I623I|NFASC_uc001hbl.1_Silent_p.I67I	NM_001005388	NP_001005388	O94856	NFASC_HUMAN	neurofascin isoform 1 precursor	817	Extracellular (Potential).|Fibronectin type-III 2.				axon guidance|cell adhesion|myelination|peripheral nervous system development	integral to membrane|node of Ranvier|plasma membrane	protein binding			ovary(3)|breast(1)|central_nervous_system(1)|skin(1)	6	all_cancers(21;0.0375)|Breast(84;0.0437)|all_epithelial(62;0.171)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.158)			AGTCCGTCATCGGTTACTCCG	0.607		NaN											0	0	0	0.016723	0	9	19									
ANKRD30A	91074	broad.mit.edu	37	10	37431050	37431050	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr10:37431050G>C	uc001iza.1	+	7	1156	c.1057G>C	c.(1057-1059)GCA>CCA	p.A353P		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	409						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						ATTTACGTGGGCAGCAAAAGG	0.408		NaN											0	0	0	0.009096	0	4	61									
ZNF248	57209	broad.mit.edu	37	10	38121105	38121105	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr10:38121105G>C	uc001izd.1	-	6	1677	c.1178C>G	c.(1177-1179)TCA>TGA	p.S393*	ZNF248_uc009xmc.2_Intron|ZNF248_uc001izb.2_Intron|ZNF248_uc001izc.2_Intron|ZNF248_uc010qeu.1_Nonsense_Mutation_p.S393*	NM_021045	NP_066383	Q8NDW4	ZN248_HUMAN	zinc finger protein 248	393	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						AGTGAGGTTTGACTTCTCCCA	0.453		NaN											0	0	0	0.016522	0	23	70									
EGR2	1959	broad.mit.edu	37	10	64575663	64575663	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr10:64575663C>G	uc010qim.1	-	2	281	c.127G>C	c.(127-129)GAA>CAA	p.E43Q	EGR2_uc010qin.1_5'UTR|EGR2_uc001jmi.2_Missense_Mutation_p.E43Q|EGR2_uc010qio.1_Missense_Mutation_p.E56Q|EGR2_uc009xph.2_Missense_Mutation_p.E43Q	NM_001136177	NP_001129649	P11161	EGR2_HUMAN	early growth response 2 protein isoform a	43					fat cell differentiation|protein export from nucleus|transcription from RNA polymerase II promoter	cytoplasm|nucleus	chromatin binding|RNA polymerase II activating transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|ubiquitin protein ligase binding|zinc ion binding			ovary(2)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)					CCTCCCAGTTCGGCATTGGGA	0.622		NaN											0	0	0	0.009096	0	4	140									
PANK1	53354	broad.mit.edu	37	10	91353589	91353589	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr10:91353589C>T	uc001kgp.1	-	4	1624	c.1468G>A	c.(1468-1470)GGA>AGA	p.G490R	PANK1_uc001kgn.1_Missense_Mutation_p.G265R|PANK1_uc001kgo.1_Intron|PANK1_uc009xtu.1_Missense_Mutation_p.G292R|uc001kgq.1_5'Flank|MIR107_hsa-mir-107|MI0000114_5'Flank	NM_148977	NP_683878	Q8TE04	PANK1_HUMAN	pantothenate kinase 1 isoform alpha	490					coenzyme A biosynthetic process|pantothenate metabolic process	cytosol|nucleus	ATP binding|pantothenate kinase activity				0					Bezafibrate(DB01393)	ACAGCAGATCCTTGAAGGCCA	0.448		NaN											0	0	0	0.008291	0	7	155									
C10orf79	80217	broad.mit.edu	37	10	105948076	105948076	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr10:105948076C>T	uc001kxw.2	-	13	1755	c.1639G>A	c.(1639-1641)GGG>AGG	p.G547R	C10orf79_uc009xxq.2_5'Flank|C10orf79_uc001kxx.3_Missense_Mutation_p.G548R	NM_025145	NP_079421	Q8NDM7	WDR96_HUMAN	hypothetical protein LOC80217	547											0		Colorectal(252;0.178)		Epithelial(162;4.83e-10)|all cancers(201;2.26e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0194)		CTGCTTCTCCCTGCTTCTGGA	0.463		NaN											0	0	0	0.004672	0	3	46									
ACADSB	36	broad.mit.edu	37	10	124793889	124793889	+	Silent	SNP	G	G	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr10:124793889G>T	uc001lhb.2	+	2	177	c.60G>T	c.(58-60)CTG>CTT	p.L20L	ACADSB_uc010qub.1_5'UTR	NM_001609	NP_001600	P45954	ACDSB_HUMAN	acyl-Coenzyme A dehydrogenase, short/branched	20					branched chain family amino acid catabolic process|fatty acid metabolic process	mitochondrial matrix	flavin adenine dinucleotide binding			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)	3		all_neural(114;0.0765)|Colorectal(57;0.102)|all_lung(145;0.11)|Lung NSC(174;0.163)		Colorectal(40;0.0811)|COAD - Colon adenocarcinoma(40;0.0835)	L-Isoleucine(DB00167)	GAAATTTCCTGACTTGTTTGT	0.353		NaN											1	0	1.37522e-17	0.007413	1.53821e-17	15	22									
KLC2	64837	broad.mit.edu	37	11	66033397	66033397	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr11:66033397C>T	uc010rov.1	+	13	1759	c.1516C>T	c.(1516-1518)CGC>TGC	p.R506C	KLC2_uc010row.1_Missense_Mutation_p.R506C|KLC2_uc009yra.2_Intron|KLC2_uc001ohb.2_Missense_Mutation_p.R506C|KLC2_uc010rox.1_Missense_Mutation_p.R429C|KLC2_uc001ohc.2_Missense_Mutation_p.R506C|KLC2_uc001ohd.2_Missense_Mutation_p.R429C|KLC2_uc001ohe.1_Missense_Mutation_p.R367C|RAB1B_uc001ohf.2_5'Flank	NM_001134775	NP_001128247	Q9H0B6	KLC2_HUMAN	kinesin light chain 2 isoform 1	506					blood coagulation	cytosol|kinesin complex|microtubule	microtubule motor activity|protein binding				0						GGGAGACCGCCGCAGCAGCCG	0.667		NaN											0	0	0	0.001168	0	4	67									
ODZ4	26011	broad.mit.edu	37	11	78419499	78419499	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr11:78419499G>C	uc001ozl.3	-	27	4579	c.4116C>G	c.(4114-4116)ATC>ATG	p.I1372M		NM_001098816	NP_001092286	Q6N022	TEN4_HUMAN	odz, odd Oz/ten-m homolog 4	1372	Extracellular (Potential).|NHL 3.				signal transduction	integral to membrane				ovary(2)|pancreas(2)	4						CATTCTGATCGATGCGTCTGA	0.507		NaN											0	0	0	0.00623	0	37	20									
SYTL2	54843	broad.mit.edu	37	11	85420380	85420380	+	Nonsense_Mutation	SNP	G	G	C			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr11:85420380G>C	uc010rth.1	-	12	2270	c.1994C>G	c.(1993-1995)TCA>TGA	p.S665*	SYTL2_uc010rtg.1_Nonsense_Mutation_p.S666*|SYTL2_uc010rti.1_Nonsense_Mutation_p.S641*|SYTL2_uc010rtj.1_Nonsense_Mutation_p.S633*|SYTL2_uc001pav.2_Nonsense_Mutation_p.S107*|SYTL2_uc010rte.1_Nonsense_Mutation_p.S67*|SYTL2_uc001pax.2_Nonsense_Mutation_p.S107*|SYTL2_uc001paz.2_5'UTR|SYTL2_uc001pba.2_Nonsense_Mutation_p.S50*|SYTL2_uc001pay.2_Nonsense_Mutation_p.S96*|SYTL2_uc001paw.2_Nonsense_Mutation_p.S67*|SYTL2_uc009yvj.2_RNA|SYTL2_uc001pbd.2_Nonsense_Mutation_p.S963*|SYTL2_uc001pbb.2_Nonsense_Mutation_p.S1003*|SYTL2_uc001pbc.2_Nonsense_Mutation_p.S987*|SYTL2_uc010rtf.1_Nonsense_Mutation_p.S483*	NM_001162951	NP_001156423	Q9HCH5	SYTL2_HUMAN	synaptotagmin-like 2 isoform g	665	C2 1.				intracellular protein transport|vesicle docking involved in exocytosis	exocytic vesicle|extrinsic to plasma membrane|melanosome|membrane fraction	neurexin binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylserine binding|Rab GTPase binding			ovary(2)|large_intestine(1)	3		Acute lymphoblastic leukemia(157;4.19e-06)|all_hematologic(158;0.0033)		KIRC - Kidney renal clear cell carcinoma(183;0.202)|Kidney(183;0.237)		TTACGGGTCTGAACGCTGTTT	0.413		NaN											0	0	0	0.01441	0	40	49									
PRB2	653247	broad.mit.edu	37	12	11546868	11546868	+	Silent	SNP	T	T	C			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr12:11546868T>C	uc010shk.1	-	3	179	c.144A>G	c.(142-144)CAA>CAG	p.Q48Q		NM_006248	NP_006239			proline-rich protein BstNI subfamily 2												0		all_cancers(2;0.00558)|Acute lymphoblastic leukemia(2;3.94e-11)|all_hematologic(2;3.6e-09)	OV - Ovarian serous cystadenocarcinoma(49;0.185)			ATGGGGGACCTTGAGGTTTGT	0.547		NaN											0	0	0	0.00308	0	5	217									
KRT73	319101	broad.mit.edu	37	12	53007514	53007514	+	Silent	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr12:53007514G>A	uc001sas.2	-	5	977	c.942C>T	c.(940-942)GCC>GCT	p.A314A		NM_175068	NP_778238	Q86Y46	K2C73_HUMAN	keratin 73	314	Rod.|Coil 2.					keratin filament	structural molecule activity			large_intestine(2)|ovary(2)|skin(2)	6				BRCA - Breast invasive adenocarcinoma(357;0.189)		TGCTCTTCCGGGCGATCTCCT	0.587		NaN											0	0	0	0.012319	0	19	71									
HOXC4	3221	broad.mit.edu	37	12	54448079	54448079	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr12:54448079C>T	uc001seu.2	+	3	1053	c.373C>T	c.(373-375)CCC>TCC	p.P125S	HOXC4_uc001sex.2_Missense_Mutation_p.P125S	NM_014620	NP_055435	P09017	HXC4_HUMAN	homeobox C4	125						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CCCCGACCATCCCTCCAGCGC	0.582		NaN											0	0	0	0.00308	0	6	27									
TMEM5	10329	broad.mit.edu	37	12	64196067	64196067	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr12:64196067G>C	uc001srq.1	+	4	729	c.625G>C	c.(625-627)GAG>CAG	p.E209Q	TMEM5_uc001srr.1_Missense_Mutation_p.E106Q|TMEM5_uc001srs.1_5'UTR	NM_014254	NP_055069	Q9Y2B1	TMEM5_HUMAN	transmembrane protein 5	209	Extracellular (Potential).					integral to plasma membrane					0		Myeloproliferative disorder(1001;0.0255)	BRCA - Breast invasive adenocarcinoma(9;0.0985)	GBM - Glioblastoma multiforme(28;9e-08)|BRCA - Breast invasive adenocarcinoma(357;0.000175)		TTGTGATAATGAGTGGATAAA	0.393		NaN											0	0	0	0.006214	0	8	36									
XPOT	11260	broad.mit.edu	37	12	64812728	64812728	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr12:64812728A>G	uc001ssb.2	+	6	769	c.343A>G	c.(343-345)ACA>GCA	p.T115A	XPOT_uc009zqm.1_Missense_Mutation_p.T25A	NM_007235	NP_009166	O43592	XPOT_HUMAN	tRNA exportin	115	Necessary for interaction with Ran, nuclear localization and nuclear import.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)		GCTTTTTGTTACAGAGTATCT	0.433		NaN											0	0	0	0.001168	0	5	42									
XPOT	11260	broad.mit.edu	37	12	64812733	64812733	+	Silent	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr12:64812733G>A	uc001ssb.2	+	6	774	c.348G>A	c.(346-348)GAG>GAA	p.E116E	XPOT_uc009zqm.1_Silent_p.E26E	NM_007235	NP_009166	O43592	XPOT_HUMAN	tRNA exportin	116	Necessary for interaction with Ran, nuclear localization and nuclear import.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)		TTGTTACAGAGTATCTCACTA	0.438		NaN											0	0	0	0.001168	0	5	42									
XPOT	11260	broad.mit.edu	37	12	64812808	64812808	+	Silent	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr12:64812808C>G	uc001ssb.2	+	6	849	c.423C>G	c.(421-423)CTC>CTG	p.L141L	XPOT_uc009zqm.1_Silent_p.L51L	NM_007235	NP_009166	O43592	XPOT_HUMAN	tRNA exportin	141	Necessary for interaction with Ran, nuclear localization and nuclear import.				intracellular protein transport|tRNA export from nucleus	cytoplasm|nucleoplasm	protein transporter activity|tRNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(28;0.0404)		GAGTAGATCTCTACCTGCGAA	0.398		NaN											0	0	0	0.006214	0	9	98									
OSBPL8	114882	broad.mit.edu	37	12	76763454	76763454	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr12:76763454C>G	uc001sye.1	-	20	2683	c.2203G>C	c.(2203-2205)GAT>CAT	p.D735H	OSBPL8_uc001syf.1_Missense_Mutation_p.D693H|OSBPL8_uc001syg.1_Missense_Mutation_p.D693H|OSBPL8_uc001syh.1_Missense_Mutation_p.D710H	NM_020841	NP_065892	Q9BZF1	OSBL8_HUMAN	oxysterol-binding protein-like protein 8 isoform	735					lipid transport		lipid binding			ovary(1)	1						GTGAGTGGATCAAGTTCAAAT	0.358		NaN											0	0	0	0.012319	0	17	56									
SDSL	113675	broad.mit.edu	37	12	113873341	113873341	+	Silent	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr12:113873341C>G	uc001tvi.2	+	7	861	c.651C>G	c.(649-651)GTC>GTG	p.V217V	SDSL_uc009zwh.2_Silent_p.V217V	NM_138432	NP_612441	Q96GA7	SDSL_HUMAN	serine dehydratase-like	217					cellular amino acid metabolic process		L-serine ammonia-lyase activity|L-threonine ammonia-lyase activity|pyridoxal phosphate binding				0					Pyridoxal Phosphate(DB00114)	GCAAGCTGGTCACACTTCCAG	0.622		NaN											0	0	0	0.009718	0	35	180									
DNAH10	196385	broad.mit.edu	37	12	124345688	124345688	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr12:124345688C>G	uc001uft.3	+	38	6550	c.6525C>G	c.(6523-6525)ATC>ATG	p.I2175M		NM_207437	NP_997320	Q8IVF4	DYH10_HUMAN	dynein, axonemal, heavy chain 10	2175	AAA 2 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|dynein complex|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(3)|skin(2)|central_nervous_system(1)	6	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000207)|Epithelial(86;0.000556)|all cancers(50;0.00346)		TCAGGGAAATCAACAAGCCAA	0.463		NaN											0	0	0	0.004482	0	7	30									
TUBA3C	7278	broad.mit.edu	37	13	19751303	19751303	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr13:19751303G>A	uc009zzj.2	-	4	869	c.820C>T	c.(820-822)CCG>TCG	p.P274S		NM_006001	NP_005992	Q13748	TBA3C_HUMAN	tubulin, alpha 3c	274					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			ovary(3)|skin(2)	5		all_cancers(29;1.31e-20)|all_epithelial(30;1.59e-20)|all_lung(29;6.91e-20)|Lung NSC(5;9.25e-17)|Hepatocellular(1;0.0207)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;6.78e-06)|Epithelial(112;3.79e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00172)|Lung(94;0.0186)|LUSC - Lung squamous cell carcinoma(192;0.108)		GAGATGACCGGGGCGTAGGTG	0.607		NaN											0	0	0	0.01441	0	49	173									
RB1	5925	broad.mit.edu	37	13	48947629	48947629	+	Splice_Site	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08			G	A	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr13:48947629G>A	uc001vcb.2	+	12	1381	c.1215_splice	c.e12+1	p.N405_splice	RB1_uc010act.1_Splice_Site_p.N106_splice	NM_000321	NP_000312	P06400	RB_HUMAN	retinoblastoma 1						androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.?(14)		lung(94)|eye(89)|central_nervous_system(47)|bone(22)|breast(21)|urinary_tract(17)|haematopoietic_and_lymphoid_tissue(14)|ovary(10)|prostate(9)|soft_tissue(8)|skin(7)|endometrium(5)|cervix(3)|liver(3)|salivary_gland(2)|stomach(2)|oesophagus(1)|adrenal_gland(1)|kidney(1)|gastrointestinal_tract_(site_indeterminate)(1)|pituitary(1)	358		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTATTTTAACGTAAGCCATAT	0.264		6	D|Mis|N|F|S		retinoblastoma|sarcoma|breast|small cell lung	retinoblastoma|sarcoma|breast|small cell lung			Hereditary_Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			0	0	0	0.00499	0	17	29									
POTEG	404785	broad.mit.edu	37	14	19553680	19553680	+	Silent	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr14:19553680C>T	uc001vuz.1	+	1	316	c.264C>T	c.(262-264)GAC>GAT	p.D88D	POTEG_uc001vva.1_RNA|POTEG_uc010ahc.1_RNA	NM_001005356	NP_001005356	Q6S5H5	POTEG_HUMAN	POTE ankyrin domain family, member G	88										ovary(1)	1						ACCACGACGACTCTGCTATGA	0.617		NaN											0	0	0	0.001984	0	6	393									
MDGA2	161357	broad.mit.edu	37	14	47530528	47530528	+	Silent	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr14:47530528C>T	uc001wwj.3	-	7	1438	c.1242G>A	c.(1240-1242)ACG>ACA	p.T414T	MDGA2_uc001wwi.3_Silent_p.T185T|MDGA2_uc010ani.2_5'UTR	NM_001113498	NP_001106970	Q7Z553	MDGA2_HUMAN	MAM domain containing 1 isoform 1	414	Ig-like 4.				spinal cord motor neuron differentiation	anchored to membrane|plasma membrane				ovary(4)|large_intestine(1)|pancreas(1)	6						CACATGTGTACGTCCCAAAAT	0.408		NaN											0	0	0	0.01441	0	36	120									
OTX2	5015	broad.mit.edu	37	14	57268797	57268797	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr14:57268797G>A	uc001xcp.2	-	3	697	c.526C>T	c.(526-528)CCC>TCC	p.P176S	OTX2_uc010aou.2_Missense_Mutation_p.P176S|OTX2_uc001xcq.2_Missense_Mutation_p.P184S	NM_172337	NP_758840	P32243	OTX2_HUMAN	orthodenticle homeobox 2 isoform b	176					axon guidance|forebrain development|midbrain development|positive regulation of embryonic development|positive regulation of gastrulation|primitive streak formation|protein complex assembly|regulation of fibroblast growth factor receptor signaling pathway|regulation of smoothened signaling pathway	growth cone|nucleus|protein complex	eukaryotic initiation factor 4E binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding			ovary(1)	1	Medulloblastoma(1;0.00184)|all_neural(1;0.00414)					TAGGTCATGGGATAGGACCTC	0.522		NaN											0	0	0	0.006122	0	13	42									
CHAC1	79094	broad.mit.edu	37	15	41245807	41245807	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr15:41245807A>T	uc001znh.2	+	1	172	c.152A>T	c.(151-153)AAC>ATC	p.N51I	CHAC1_uc010uct.1_Missense_Mutation_p.N51I	NM_024111	NP_077016	Q9BUX1	CHAC1_HUMAN	ChaC, cation transport regulator-like 1 isoform	51					apoptosis in response to endoplasmic reticulum stress|response to unfolded protein	cytosol	protein binding				0		all_cancers(109;1.42e-13)|all_epithelial(112;1.48e-11)|Lung NSC(122;5.77e-09)|all_lung(180;1.08e-07)|Melanoma(134;0.091)|Colorectal(260;0.175)|Ovarian(310;0.243)		GBM - Glioblastoma multiforme(113;2.66e-05)|COAD - Colon adenocarcinoma(120;0.15)|BRCA - Breast invasive adenocarcinoma(123;0.163)		GCAGCCCCGAACACCCCGCCC	0.687		NaN											0	0	0	0.010504	0	13	60									
KIF23	9493	broad.mit.edu	37	15	69709843	69709843	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr15:69709843A>G	uc002asb.2	+	3	320	c.203A>G	c.(202-204)TAT>TGT	p.Y68C	KIF23_uc002asc.2_Missense_Mutation_p.Y68C|KIF23_uc010bii.2_Missense_Mutation_p.I4V|KIF23_uc010bih.1_RNA	NM_138555	NP_612565	Q02241	KIF23_HUMAN	kinesin family member 23 isoform 1	68	Kinesin-motor.				blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding				0						AATGGAGACTATAAGGAGGTA	0.378		NaN											0	0	0	0.007835	0	33	75									
CSK	1445	broad.mit.edu	37	15	75094356	75094356	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr15:75094356G>A	uc010bkb.1	+	13	1285	c.1102G>A	c.(1102-1104)GAC>AAC	p.D368N	CSK_uc002ays.2_Missense_Mutation_p.D368N|CSK_uc010bkc.1_Missense_Mutation_p.D177N	NM_001127190	NP_001120662	P41240	CSK_HUMAN	c-src tyrosine kinase	368	Protein kinase.				blood coagulation|epidermal growth factor receptor signaling pathway|T cell costimulation|T cell receptor signaling pathway	centrosome|cytosol|Golgi apparatus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein C-terminus binding			lung(2)|central_nervous_system(1)	3						CACTAAGTCTGACGTGTGGAG	0.532		NaN											0	0	0	0.015359	0	26	52									
CSK	1445	broad.mit.edu	37	15	75094364	75094364	+	Missense_Mutation	SNP	G	G	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr15:75094364G>T	uc010bkb.1	+	13	1293	c.1110G>T	c.(1108-1110)TGG>TGT	p.W370C	CSK_uc002ays.2_Missense_Mutation_p.W370C|CSK_uc010bkc.1_Missense_Mutation_p.W179C	NM_001127190	NP_001120662	P41240	CSK_HUMAN	c-src tyrosine kinase	370	Protein kinase.				blood coagulation|epidermal growth factor receptor signaling pathway|T cell costimulation|T cell receptor signaling pathway	centrosome|cytosol|Golgi apparatus	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein C-terminus binding			lung(2)|central_nervous_system(1)	3						CTGACGTGTGGAGTTTCGGAA	0.537		NaN											1	0	2.87052e-16	0.005524	3.16386e-16	27	52									
MSLNL	401827	broad.mit.edu	37	16	830490	830490	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr16:830490G>A	uc002cjz.1	-	3	511	c.511C>T	c.(511-513)CGC>TGC	p.R171C		NM_001025190	NP_001020361	Q96KJ4	MSLNL_HUMAN	mesothelin-like	Error:Variant_position_missing_in_Q96KJ4_after_alignment					cell adhesion	integral to membrane				breast(3)|ovary(1)	4						GGATGCGTGCGGGCACGCATG	0.547		NaN											0	0	0	0.001168	0	5	190									
PDILT	204474	broad.mit.edu	37	16	20370721	20370721	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr16:20370721C>T	uc002dhc.1	-	12	1898	c.1675G>A	c.(1675-1677)GAG>AAG	p.E559K		NM_174924	NP_777584	Q8N807	PDILT_HUMAN	protein disulfide isomerase-like, testis	559					cell differentiation|cell redox homeostasis|multicellular organismal development|spermatogenesis	endoplasmic reticulum	isomerase activity			large_intestine(1)	1						ACCACCTCCTCAGATGTTTTC	0.493		NaN											0	0	0	0.01441	0	50	282									
SMTNL2	342527	broad.mit.edu	37	17	4496232	4496232	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr17:4496232G>A	uc002fyf.1	+	3	563	c.496G>A	c.(496-498)GAT>AAT	p.D166N	SMTNL2_uc002fye.2_Missense_Mutation_p.D22N	NM_001114974	NP_001108446	Q2TAL5	SMTL2_HUMAN	smoothelin-like 2 isoform 1	166											0				READ - Rectum adenocarcinoma(115;0.0325)		AGGTCCAGGCGATGGACCCCC	0.662		NaN											0	0	0	0.006999	0	31	19									
TP53	7157	broad.mit.edu	37	17	7577085	7577085	+	Missense_Mutation	SNP	C	C	T	rs112431538		TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr17:7577085C>T	uc002gim.2	-	8	1047	c.853G>A	c.(853-855)GAG>AAG	p.E285K	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.E285K|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E153K|TP53_uc010cng.1_Missense_Mutation_p.E153K|TP53_uc002gii.1_Missense_Mutation_p.E153K|TP53_uc010cnh.1_Missense_Mutation_p.E285K|TP53_uc010cni.1_Missense_Mutation_p.E285K|TP53_uc002gij.2_Missense_Mutation_p.E285K	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	285	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> K (in sporadic cancers; somatic mutation).|E -> V (in sporadic cancers; somatic mutation).|E -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|E -> A (in a sporadic cancer; somatic mutation).|E -> G (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E285K(95)|p.E285*(16)|p.E285V(13)|p.0?(7)|p.E285Q(4)|p.E285E(3)|p.E285G(3)|p.E285A(2)|p.?(2)|p.R283fs*16(2)|p.E285_N288delEEEN(1)|p.R282_E287delRRTEEE(1)|p.T284_G293del10(1)|p.G279fs*59(1)|p.E285fs*13(1)|p.L265_K305del41(1)|p.T284fs*57(1)|p.R283fs*56(1)|p.V272_K292del21(1)|p.R283fs*59(1)|p.C275fs*20(1)|p.E285_L289delEEENL(1)|p.E285fs*60(1)|p.E285fs*20(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		TTCTCTTCCTCTGTGCGCCGG	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.007413	0	18	23									
EFCAB5	374786	broad.mit.edu	37	17	28380460	28380460	+	Silent	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr17:28380460G>A	uc002het.2	+	10	1680	c.1488G>A	c.(1486-1488)CAG>CAA	p.Q496Q	EFCAB5_uc010wbi.1_Silent_p.Q239Q|EFCAB5_uc010wbj.1_Silent_p.Q440Q|EFCAB5_uc010wbk.1_Silent_p.Q153Q|EFCAB5_uc010csd.2_RNA|EFCAB5_uc010cse.2_Silent_p.Q375Q|EFCAB5_uc010csf.2_Silent_p.Q375Q	NM_198529	NP_940931	A4FU69	EFCB5_HUMAN	EF-hand calcium binding domain 5 isoform a	496							calcium ion binding			ovary(1)|skin(1)	2						TTAACGAACAGAGAACATCAA	0.393		NaN											0	0	0	0.020292	0	12	41									
ZNF652	22834	broad.mit.edu	37	17	47395037	47395037	+	Silent	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr17:47395037C>T	uc002iov.3	-	2	515	c.51G>A	c.(49-51)GTG>GTA	p.V17V	ZNF652_uc002iow.2_Silent_p.V17V|ZNF652_uc002iou.3_RNA	NM_001145365	NP_001138837	Q9Y2D9	ZN652_HUMAN	zinc finger protein 652	17					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1	all_cancers(4;6.81e-14)|Breast(4;4.97e-29)|all_epithelial(4;1.53e-17)		BRCA - Breast invasive adenocarcinoma(1;3.1e-14)|Epithelial(5;2.92e-06)|all cancers(6;3.15e-05)			CTGCTACATGCACAGCACAGT	0.448		NaN											0	0	0	0.00308	0	5	38									
MED13	9969	broad.mit.edu	37	17	60028189	60028189	+	Silent	SNP	A	A	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr17:60028189A>G	uc002izo.2	-	28	6365	c.6288T>C	c.(6286-6288)CTT>CTC	p.L2096L		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	2096					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						GCAATACCTTAAGAAAAAGGG	0.413		NaN											0	0	0	0.01441	0	39	81									
ITGB4	3691	broad.mit.edu	37	17	73723498	73723498	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr17:73723498G>A	uc002jpg.2	+	4	363	c.176G>A	c.(175-177)CGG>CAG	p.R59Q	ITGB4_uc002jph.2_Missense_Mutation_p.R59Q|ITGB4_uc010dgo.2_Missense_Mutation_p.R59Q|ITGB4_uc002jpi.3_Missense_Mutation_p.R59Q|ITGB4_uc010dgp.1_Missense_Mutation_p.R59Q|ITGB4_uc002jpj.2_Missense_Mutation_p.R59Q	NM_000213	NP_000204	P16144	ITB4_HUMAN	integrin beta 4 isoform 1 precursor	59	PSI.|Extracellular (Potential).				cell communication|cell motility|cell-matrix adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|multicellular organismal development|response to wounding	cell leading edge|cell surface|hemidesmosome|integrin complex	protein binding|receptor activity			lung(4)	4	all_cancers(13;1.5e-07)		all cancers(21;8.32e-07)|Epithelial(20;1.92e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00194)|Lung(188;0.132)|LUSC - Lung squamous cell carcinoma(166;0.154)			TTCAGGGACCGGCGCTGCAAC	0.637		NaN											0	0	0	0.016723	0	10	41									
FAM59A	64762	broad.mit.edu	37	18	29848220	29848220	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr18:29848220C>T	uc002kxl.2	-	6	2301	c.2245G>A	c.(2245-2247)GAT>AAT	p.D749N	FAM59A_uc002kxk.1_Missense_Mutation_p.D748N	NM_022751	NP_073588	Q9H706	FA59A_HUMAN	family with sequence similarity 59, member A	749										ovary(1)|skin(1)	2						TCAGCACCATCAATTTTCAGA	0.522		NaN											0	0	0	0.004656	0	23	56									
FEM1A	55527	broad.mit.edu	37	19	4792857	4792857	+	Nonsense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:4792857C>T	uc002mbf.2	+	1	1130	c.991C>T	c.(991-993)CAG>TAG	p.Q331*	uc002mbg.1_RNA	NM_018708	NP_061178	Q9BSK4	FEM1A_HUMAN	fem-1 homolog a	331	TPR 1.				regulation of ubiquitin-protein ligase activity	cytoplasm	binding|ubiquitin-protein ligase activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0139)		GCTGCGTCACCAGGGGGGCGA	0.602		NaN											0	0	0	0.005443	0	22	40									
MUC16	94025	broad.mit.edu	37	19	9048764	9048764	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:9048764A>G	uc002mkp.2	-	5	33071	c.32867T>C	c.(32866-32868)CTT>CCT	p.L10956P		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10958	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGGTTCACCAAGAGAAAAAGT	0.498		NaN											0	0	0	0.00308	0	4	86									
MUC16	94025	broad.mit.edu	37	19	9048771	9048771	+	Missense_Mutation	SNP	A	A	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:9048771A>G	uc002mkp.2	-	5	33064	c.32860T>C	c.(32860-32862)TTT>CTT	p.F10954L		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	10956	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						CCAAGAGAAAAAGTCAGAATT	0.483		NaN											0	0	0	0.00308	0	4	90									
ZNF878	729747	broad.mit.edu	37	19	12155757	12155757	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:12155757C>A	uc002mta.1	-	5	600	c.600G>T	c.(598-600)AGG>AGT	p.R200S		NM_001080404	NP_001073873	C9JN71	ZN878_HUMAN	zinc finger protein 878	153	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						AACTGGGAAACCTGAATGCTT	0.423		NaN											1	0	5.18039e-06	0.00308	5.5478e-06	7	94									
ZNF799	90576	broad.mit.edu	37	19	12501446	12501446	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:12501446T>C	uc010dyt.2	-	4	1916	c.1766A>G	c.(1765-1767)GAA>GGA	p.E589G	ZNF799_uc002mts.3_Intron	NM_001080821	NP_001074290	Q96GE5	ZN799_HUMAN	zinc finger protein 799	589	C2H2-type 17.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|ovary(2)|skin(1)	6						TTCCTTACATTCATACGGGTT	0.413		NaN											0	0	0	0.004672	0	3	36									
ZNF564	163050	broad.mit.edu	37	19	12637723	12637723	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:12637723C>T	uc002mty.2	-	4	1409	c.1199G>A	c.(1198-1200)AGA>AAA	p.R400K	ZNF709_uc002mtx.3_Intron	NM_144976	NP_659413	Q8TBZ8	ZN564_HUMAN	zinc finger protein 564	400	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GTCAAAGGCTCTACCACATAC	0.433		NaN											0	0	0	0.001168	0	5	118									
ZNF493	284443	broad.mit.edu	37	19	21606712	21606712	+	Silent	SNP	T	T	C			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:21606712T>C	uc002npx.2	+	2	1147	c.867T>C	c.(865-867)TCT>TCC	p.S289S	ZNF493_uc002npw.2_Silent_p.S417S|ZNF493_uc002npy.2_Silent_p.S289S	NM_175910	NP_787106	Q6ZR52	ZN493_HUMAN	zinc finger protein 493 isoform 1	289	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						ATAAGGAGTCTTCACACCTTA	0.348		NaN											0	0	0	0.014758	0	4	35									
ZNF208	7757	broad.mit.edu	37	19	22156621	22156621	+	Silent	SNP	A	A	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:22156621A>G	uc002nqp.2	-	4	1364	c.1215T>C	c.(1213-1215)GGT>GGC	p.G405G	ZNF208_uc002nqo.1_Intron|ZNF208_uc010ecw.1_5'Flank	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				ACATACTAAAACCTTTGCCAC	0.393		NaN											0	0	0	0.004672	0	3	62									
ZNF91	7644	broad.mit.edu	37	19	23544783	23544783	+	Missense_Mutation	SNP	C	C	T	rs410211		TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:23544783C>T	uc002nre.2	-	4	1111	c.998G>A	c.(997-999)CGT>CAT	p.R333H	ZNF91_uc010xrj.1_Missense_Mutation_p.R301H	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	333	C2H2-type 7.			R -> H (in Ref. 1; AAA59469).		nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				GGTTGAAGAACGGCTAAAAGC	0.393		NaN											0	0	0	0.001984	0	6	94									
ZNF681	148213	broad.mit.edu	37	19	23927146	23927146	+	Silent	SNP	A	A	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:23927146A>G	uc002nrk.3	-	4	1348	c.1206T>C	c.(1204-1206)GCT>GCC	p.A402A	ZNF681_uc002nrl.3_Silent_p.A333A|ZNF681_uc002nrj.3_Silent_p.A333A	NM_138286	NP_612143	Q96N22	ZN681_HUMAN	zinc finger protein 681	402	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_lung(12;0.11)|Lung NSC(12;0.163)|all_epithelial(12;0.206)				ACTTGTTAAAAGCTTTGCCAC	0.398		NaN											0	0	0	0.001984	0	3	66									
ZNF599	148103	broad.mit.edu	37	19	35251038	35251038	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:35251038C>G	uc010edn.1	-	4	1056	c.668G>C	c.(667-669)GGA>GCA	p.G223A	ZNF599_uc010edm.1_Missense_Mutation_p.G186A	NM_001007248	NP_001007249	Q96NL3	ZN599_HUMAN	zinc finger protein 599	223					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|skin(1)	2	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			GGGCTTCACTCCAGCATGAAT	0.473		NaN											0	0	0	0.004482	0	6	204									
SIPA1L3	23094	broad.mit.edu	37	19	38579389	38579389	+	Silent	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:38579389G>A	uc002ohk.2	+	4	2072	c.1563G>A	c.(1561-1563)GAG>GAA	p.E521E		NM_015073	NP_055888	O60292	SI1L3_HUMAN	signal-induced proliferation-associated 1 like	521					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			ovary(1)|central_nervous_system(1)	2			Lung(45;0.000246)|LUSC - Lung squamous cell carcinoma(53;0.000292)			GCGTGGATGAGAAGCTGGGGC	0.587		NaN											0	0	0	0.020292	0	15	33									
LIPE	3991	broad.mit.edu	37	19	42931254	42931254	+	Silent	SNP	T	T	C			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:42931254T>C	uc002otr.2	-	1	325	c.48A>G	c.(46-48)GAA>GAG	p.E16E	uc010eif.1_Intron|uc002ott.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron|LIPE_uc002ots.1_5'Flank	NM_005357	NP_005348	Q05469	LIPS_HUMAN	hormone-sensitive lipase	16					cholesterol metabolic process|protein phosphorylation|triglyceride catabolic process	caveola|cytosol	hormone-sensitive lipase activity|protein binding			ovary(1)|breast(1)	2		Prostate(69;0.00682)				TCTGGTGTGGTTCAGGTTGCC	0.517		NaN											0	0	0	0.006214	0	7	28									
ZNF229	7772	broad.mit.edu	37	19	44933766	44933766	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:44933766C>T	uc002oze.1	-	6	1624	c.1190G>A	c.(1189-1191)AGG>AAG	p.R397K	ZNF229_uc010ejk.1_Missense_Mutation_p.R51K|ZNF229_uc010ejl.1_Missense_Mutation_p.R391K	NM_014518	NP_055333	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	397	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4		Prostate(69;0.0352)				AGTGTGGACCCTCTGATGGAC	0.502		NaN											0	0	0	0.013726	0	32	51									
ZNF577	84765	broad.mit.edu	37	19	52376698	52376698	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:52376698C>A	uc010yde.1	-	7	936	c.545G>T	c.(544-546)GGA>GTA	p.G182V	ZNF577_uc010ydd.1_Intron|ZNF577_uc002pxx.3_Missense_Mutation_p.G123V|ZNF577_uc002pxv.2_Missense_Mutation_p.G175V|ZNF577_uc002pxw.2_Missense_Mutation_p.G116V	NM_032679	NP_116068	Q9BSK1	ZN577_HUMAN	zinc finger protein 577 isoform a	182					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		GGGTTTCTCTCCTCTTTCAGT	0.468		NaN											1	0	0.000602214	0.014758	0.000627134	4	88									
ZNF611	81856	broad.mit.edu	37	19	53209409	53209409	+	Nonsense_Mutation	SNP	G	G	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:53209409G>T	uc002pzz.2	-	7	1216	c.899C>A	c.(898-900)TCA>TAA	p.S300*	ZNF611_uc010eqc.2_Nonsense_Mutation_p.S230*|ZNF611_uc010ydo.1_Nonsense_Mutation_p.S230*|ZNF611_uc010ydr.1_Nonsense_Mutation_p.S231*|ZNF611_uc010ydp.1_Nonsense_Mutation_p.S300*|ZNF611_uc010ydq.1_Nonsense_Mutation_p.S300*|ZNF611_uc002qaa.3_Nonsense_Mutation_p.S230*	NM_030972	NP_112234	Q8N823	ZN611_HUMAN	zinc finger protein 611 isoform a	300	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(262;0.0233)|GBM - Glioblastoma multiforme(134;0.04)		GGTAAGGGATGACTCCTGACT	0.413		NaN											1	0	7.38237e-10	0.00632	7.96241e-10	27	192									
ZNF347	84671	broad.mit.edu	37	19	53644362	53644362	+	Silent	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:53644362C>T	uc002qbb.1	-	5	1788	c.1719G>A	c.(1717-1719)GAG>GAA	p.E573E	ZNF347_uc010eql.1_Silent_p.E574E|ZNF347_uc002qbc.1_Silent_p.E574E	NM_032584	NP_115973	Q96SE7	ZN347_HUMAN	zinc finger protein 347	573	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0179)		CCTTGCCACACTCATTACATT	0.408		NaN											0	0	0	0.00308	0	5	247									
ZNF628	89887	broad.mit.edu	37	19	55993619	55993619	+	Silent	SNP	G	G	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr19:55993619G>T	uc002qld.2	+	3	1612	c.1047G>T	c.(1045-1047)GCG>GCT	p.A349A	NAT14_uc002qle.1_5'Flank	NM_033113	NP_149104	Q5EBL2	ZN628_HUMAN	zinc finger protein 628	349	Pro-rich.					nucleus	DNA binding|zinc ion binding				0	Breast(117;0.155)		BRCA - Breast invasive adenocarcinoma(297;0.18)|LUSC - Lung squamous cell carcinoma(43;0.193)	GBM - Glioblastoma multiforme(193;0.0531)		CCGCCCCCGCGCCTGGCTTTG	0.771		NaN											1	0	2.61681e-11	0.020292	2.84273e-11	10	6									
LRRTM1	347730	broad.mit.edu	37	2	80530714	80530714	+	Silent	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr2:80530714G>A	uc002sok.1	-	2	501	c.231C>T	c.(229-231)CTC>CTT	p.L77L	CTNNA2_uc010yse.1_Intron|CTNNA2_uc010ysf.1_Intron|CTNNA2_uc010ysg.1_Intron|CTNNA2_uc010ysh.1_Intron|CTNNA2_uc010ysi.1_5'Flank|LRRTM1_uc002soj.3_RNA	NM_178839	NP_849161	Q86UE6	LRRT1_HUMAN	leucine rich repeat transmembrane neuronal 1	77	Lumenal (Potential).					axon|endoplasmic reticulum membrane|growth cone|integral to membrane				ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5						GCAGCTCCGAGAGGCTGTTGT	0.647		NaN								HNSCC(69;0.2)			0	0	0	0.009096	0	4	63									
NEB	4703	broad.mit.edu	37	2	152484126	152484126	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr2:152484126C>T	uc010fnx.2	-	65	9516	c.9325G>A	c.(9325-9327)GAC>AAC	p.D3109N		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	3109	Nebulin 84.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TTCTTGTAGTCCACATCGCTG	0.522		NaN											0	0	0	0.004482	0	8	250									
TTN	7273	broad.mit.edu	37	2	179613777	179613777	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr2:179613777G>C	uc002unb.2	-	46	13574	c.13350C>G	c.(13348-13350)CAC>CAG	p.H4450Q	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCCCGGGTAGTGTATCTCTT	0.333		NaN											0	0	0	0.014758	0	4	35									
NBEAL1	65065	broad.mit.edu	37	2	204058632	204058632	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr2:204058632G>C	uc002uzt.3	+	46	7282	c.6949G>C	c.(6949-6951)GAG>CAG	p.E2317Q	NBEAL1_uc002uzs.3_Intron	NM_001114132	NP_001107604	Q6ZS30	NBEL1_HUMAN	neurobeachin-like 1 isoform 3	2317							binding			ovary(1)|skin(1)	2						ATTTTTTATAGAGGTAATATC	0.308		NaN											0	0	0	0.014758	0	3	36									
SMARCAL1	50485	broad.mit.edu	37	2	217342939	217342939	+	Missense_Mutation	SNP	G	G	C	rs119473033		TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr2:217342939G>C	uc002vgc.3	+	17	2872	c.2542G>C	c.(2542-2544)GAG>CAG	p.E848Q	SMARCAL1_uc010fvf.2_RNA|SMARCAL1_uc002vgd.3_Missense_Mutation_p.E848Q|SMARCAL1_uc010fvg.2_Missense_Mutation_p.E826Q	NM_014140	NP_054859	Q9NZC9	SMAL1_HUMAN	SWI/SNF-related matrix-associated	848	Helicase C-terminal.				chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			ovary(3)|breast(3)|skin(1)	7		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		CCTGATTCAAGAGAAGATTAA	0.458		NaN							Schimke_Immuno-Osseous_Dysplasia				0	0	0	0.007835	0	33	51									
DOCK10	55619	broad.mit.edu	37	2	225651829	225651829	+	Silent	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr2:225651829G>A	uc010fwz.1	-	50	5804	c.5565C>T	c.(5563-5565)GAC>GAT	p.D1855D	DOCK10_uc002vob.2_Silent_p.D1849D|DOCK10_uc002voa.2_Silent_p.D511D|DOCK10_uc002voc.2_Silent_p.D676D	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1855	DHR-2.						GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		ACCGATGAATGTCGTAGTAGA	0.403		NaN											0	0	0	0.001168	0	5	69									
SLC16A14	151473	broad.mit.edu	37	2	230911105	230911105	+	Missense_Mutation	SNP	G	G	C	rs111627569		TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr2:230911105G>C	uc002vqd.1	-	4	1100	c.737C>G	c.(736-738)ACA>AGA	p.T246R	FBXO36_uc010fxi.1_Intron|SLC16A14_uc002vqe.2_Missense_Mutation_p.T246R|SLC16A14_uc002vqf.2_Missense_Mutation_p.T246R	NM_152527	NP_689740	Q7RTX9	MOT14_HUMAN	solute carrier family 16 (monocarboxylic acid	246	Extracellular (Potential).					integral to membrane|plasma membrane	symporter activity			ovary(4)|skin(2)	6		Renal(207;0.025)|all_hematologic(139;0.122)|all_lung(227;0.149)|Acute lymphoblastic leukemia(138;0.164)		Epithelial(121;7.31e-13)|all cancers(144;5.1e-10)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(119;0.00948)		CTTCTCTTCTGTTCTTCCCTG	0.582		NaN											0	0	0	0.001984	0	5	106									
SRC	6714	broad.mit.edu	37	20	36012632	36012632	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr20:36012632G>A	uc002xgx.2	+	4	525	c.76G>A	c.(76-78)GGC>AGC	p.G26S	SRC_uc002xgy.2_Missense_Mutation_p.G26S	NM_005417	NP_005408	P12931	SRC_HUMAN	proto-oncogene tyrosine-protein kinase SRC	26					axon guidance|bone resorption|cell junction assembly|cellular membrane organization|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|interspecies interaction between organisms|intracellular protein kinase cascade|leukocyte migration|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of integrin activation|Ras protein signal transduction|regulation of bone resorption|regulation of vascular permeability|response to interleukin-1|signal complex assembly|T cell costimulation	caveola|cytosol|mitochondrial inner membrane	ATP binding|heme binding|integrin binding|ion channel binding|non-membrane spanning protein tyrosine kinase activity|SH2 domain binding|SH3/SH2 adaptor activity			large_intestine(10)|lung(1)|central_nervous_system(1)|endometrium(1)	13		Myeloproliferative disorder(115;0.00878)			Dasatinib(DB01254)	GAACGTGCACGGCGCTGGCGG	0.741		NaN											0	0	0	0.004482	0	4	31									
KCNQ2	3785	broad.mit.edu	37	20	62044922	62044922	+	Silent	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr20:62044922G>A	uc002yey.1	-	15	1821	c.1644C>T	c.(1642-1644)TTC>TTT	p.F548F	KCNQ2_uc002yez.1_Silent_p.F517F|KCNQ2_uc002yfa.1_Silent_p.F530F|KCNQ2_uc002yfb.1_Silent_p.F520F	NM_172107	NP_742105	O43526	KCNQ2_HUMAN	potassium voltage-gated channel KQT-like protein	548	Cytoplasmic (Potential).				axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	TGGACACCAGGAACCGCATGA	0.647		NaN											0	0	0	0.013726	0	30	85									
BCL2L13	23786	broad.mit.edu	37	22	18210132	18210132	+	Silent	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr22:18210132G>A	uc002zmw.2	+	7	1508	c.1290G>A	c.(1288-1290)GAG>GAA	p.E430E	BCL2L13_uc002zmx.2_Silent_p.E268E|BCL2L13_uc002zmy.2_3'UTR|BCL2L13_uc010gqy.2_Silent_p.E268E|BCL2L13_uc011agk.1_Silent_p.E306E|BCL2L13_uc010gqz.2_Silent_p.E150E|BCL2L13_uc002zmz.2_Silent_p.E268E|BCL2L13_uc002zna.2_Silent_p.E150E	NM_015367	NP_056182	Q9BXK5	B2L13_HUMAN	BCL2-like 13 (apoptosis facilitator)	430	B.				induction of apoptosis	integral to membrane|mitochondrial membrane|nucleus	caspase activator activity			ovary(1)|lung(1)|central_nervous_system(1)|skin(1)	4		all_epithelial(15;0.123)		Lung(27;0.199)		CTGCCAGCGAGAAGAAGCCCG	0.592		NaN											0	0	0	0.016723	0	12	29									
GNAZ	2781	broad.mit.edu	37	22	23438065	23438065	+	Silent	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr22:23438065C>T	uc002zwu.1	+	2	720	c.183C>T	c.(181-183)TTC>TTT	p.F61F	RTDR1_uc002zwt.2_Intron	NM_002073	NP_002064	P19086	GNAZ_HUMAN	guanine nucleotide binding protein, alpha z	61						endoplasmic reticulum|heterotrimeric G-protein complex|nuclear envelope	G-protein beta/gamma-subunit complex binding|GTP binding|GTPase activity|guanyl-nucleotide exchange factor activity|metabotropic serotonin receptor binding|receptor signaling protein activity			kidney(1)|skin(1)	2	all_hematologic(9;0.0197)|Acute lymphoblastic leukemia(84;0.181)			READ - Rectum adenocarcinoma(21;0.166)		GCGGCGGCTTCAACCTGGAGG	0.597		NaN											0	0	0	0.01441	0	56	98									
NDUFA6	4700	broad.mit.edu	37	22	42486786	42486786	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr22:42486786C>G	uc003bcb.2	-	1	103	c.41G>C	c.(40-42)TGC>TCC	p.C14S	uc003bcc.1_5'Flank|uc003bcd.1_5'Flank	NM_002490	NP_002481	P56556	NDUA6_HUMAN	NADH dehydrogenase (ubiquinone) 1 alpha	14					mitochondrial electron transport, NADH to ubiquinone|response to oxidative stress|transport	mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity				0					NADH(DB00157)	CACCCCTTTGCAAGCAGCGCG	0.622		NaN									OREG0026602	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00308	0	6	212									
FANCD2	2177	broad.mit.edu	37	3	10107166	10107166	+	Missense_Mutation	SNP	G	G	A	rs150217066		TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr3:10107166G>A	uc003buw.2	+	24	2335	c.2257G>A	c.(2257-2259)GAT>AAT	p.D753N	FANCD2_uc003bux.1_Missense_Mutation_p.D753N|FANCD2_uc003buy.1_Missense_Mutation_p.D753N|FANCD2_uc010hcw.1_RNA	NM_033084	NP_149075	Q9BXW9	FACD2_HUMAN	Fanconi anemia complementation group D2 isoform	753					DNA repair|response to gamma radiation	nucleoplasm	protein binding|protein binding			central_nervous_system(2)|ovary(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(96;0.148)		GGAGGAGATTGATGGTCTACT	0.448		NaN	D|Mis|N|F			AML|leukemia		Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.013726	0	28	57									
NUP210	23225	broad.mit.edu	37	3	13367407	13367407	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr3:13367407G>A	uc003bxv.1	-	33	4615	c.4532C>T	c.(4531-4533)TCA>TTA	p.S1511L		NM_024923	NP_079199	Q8TEM1	PO210_HUMAN	nucleoporin 210 precursor	1511	Lumenal (Probable).				carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	endoplasmic reticulum membrane|nuclear membrane|nuclear pore				ovary(3)|large_intestine(3)|skin(3)|pancreas(1)|liver(1)	11	all_neural(104;0.187)					GCTGTTGGCCGAGGAGCTCCA	0.622		NaN											0	0	0	0.010504	0	14	76									
STAB1	23166	broad.mit.edu	37	3	52552854	52552854	+	Nonsense_Mutation	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr3:52552854C>G	uc003dej.2	+	48	5077	c.5003C>G	c.(5002-5004)TCA>TGA	p.S1668*	STAB1_uc003dek.1_5'UTR|STAB1_uc003del.2_5'Flank	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	1668	Extracellular (Potential).|FAS1 5.				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		ACGGCCCTCTCAGGGCACCCA	0.547		NaN											0	0	0	0.009096	0	4	27									
DCBLD2	131566	broad.mit.edu	37	3	98531284	98531284	+	Missense_Mutation	SNP	T	T	C			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr3:98531284T>C	uc003dtd.2	-	10	1618	c.1255A>G	c.(1255-1257)AAC>GAC	p.N419D	DCBLD2_uc003dte.2_Missense_Mutation_p.N419D	NM_080927	NP_563615	Q96PD2	DCBD2_HUMAN	discoidin, CUB and LCCL domain containing 2	419	Extracellular (Potential).|F5/8 type C.				cell adhesion|intracellular receptor mediated signaling pathway|negative regulation of cell growth|wound healing	cell surface|integral to plasma membrane				ovary(2)|central_nervous_system(1)	3						GGCAAAAAGTTATTACGCACA	0.348		NaN											0	0	0	0.010729	0	12	31									
TFG	10342	broad.mit.edu	37	3	100463681	100463681	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr3:100463681G>C	uc003due.2	+	7	1175	c.726G>C	c.(724-726)CAG>CAC	p.Q242H	TFG_uc003duf.2_Missense_Mutation_p.Q242H|TFG_uc003dug.2_Missense_Mutation_p.Q238H|TFG_uc003duh.2_Missense_Mutation_p.Q238H|TFG_uc003dui.2_Missense_Mutation_p.Q242H	NM_006070	NP_006061	Q92734	TFG_HUMAN	TRK-fused	242					positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm	signal transducer activity		TFG/ALK(7)	haematopoietic_and_lymphoid_tissue(7)|lung(2)|large_intestine(1)|prostate(1)	11						TTTCAGGTCAGATGTACCAAC	0.458		NaN	T	NTRK1|ALK	papillary thyroid|ALCL|NSCLC								0	0	0	0.01441	0	45	102									
GRAMD1C	54762	broad.mit.edu	37	3	113619898	113619898	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr3:113619898C>G	uc003eaq.3	+	7	637	c.561C>G	c.(559-561)TTC>TTG	p.F187L	GRAMD1C_uc011bil.1_RNA|GRAMD1C_uc011bim.1_RNA|GRAMD1C_uc003ear.2_Missense_Mutation_p.F20L|GRAMD1C_uc003eas.2_5'UTR	NM_017577	NP_060047	Q8IYS0	GRM1C_HUMAN	GRAM domain containing 1C	187						integral to membrane				ovary(2)|skin(1)	3						GACAGGAATTCTGGCAACTGC	0.373		NaN											0	0	0	0.01892	0	20	48									
RBP1	5947	broad.mit.edu	37	3	139236517	139236517	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr3:139236517C>T	uc003eti.2	-	4	657	c.546G>A	c.(544-546)ATG>ATA	p.M182I		NM_002899	NP_002890	P09455	RET1_HUMAN	retinol binding protein 1, cellular isoform a	120						cytoplasm	retinal binding|retinol binding|transporter activity				0					Vitamin A(DB00162)	CTTCCACTCTCATCTCCTGAA	0.488		NaN											0	0	0	0.00623	0	34	92									
ZNF732	654254	broad.mit.edu	37	4	265271	265272	+	Missense_Mutation	DNP	CA	CA	TG			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr4:265271_265272CA>TG	uc011buu.1	-	3	1385_1386	c.1371_1372TG>CA	c.(1369-1374)TCTGCA>TCCACA	p.A458T	ZNF732_uc010ibb.1_Intron	NM_001137608	NP_001131080	B4DXR9	ZN732_HUMAN	zinc finger protein 732	459	C2H2-type 12.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTCAGGTATGCAGACCATCCAA	0.391		NaN											0	0	0	0.004672	0	3	8									
UGT2B28	54490	broad.mit.edu	37	4	70160324	70160324	+	Missense_Mutation	SNP	T	T	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr4:70160324T>A	uc003hej.2	+	6	1389	c.1387T>A	c.(1387-1389)TGG>AGG	p.W463R	UGT2B28_uc010ihr.2_3'UTR	NM_053039	NP_444267	Q9BY64	UDB28_HUMAN	UDP glucuronosyltransferase 2 family,	463					xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(1)	1					Flunitrazepam(DB01544)	AGCAGTCTTCTGGATTGAATT	0.413		NaN											0	0	0	0.00874	0	33	79									
CCRN4L	25819	broad.mit.edu	37	4	139966392	139966392	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr4:139966392G>C	uc003ihl.2	+	3	1253	c.1060G>C	c.(1060-1062)GAT>CAT	p.D354H		NM_012118	NP_036250	Q9UK39	NOCT_HUMAN	CCR4 carbon catabolite repression 4-like	354					rhythmic process|transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity			ovary(1)	1	all_hematologic(180;0.162)					GCTGAGTGCTGATGGGCAGTC	0.517		NaN											0	0	0	0.00499	0	15	47									
HAND2	9464	broad.mit.edu	37	4	174450071	174450071	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr4:174450071C>G	uc003ith.1	-	1	1308	c.370G>C	c.(370-372)GAG>CAG	p.E124Q	NBLA00301_uc011ckd.1_5'Flank|NBLA00301_uc003itl.3_5'Flank|NBLA00301_uc003itj.2_5'Flank|NBLA00301_uc010irf.2_5'Flank|NBLA00301_uc010irg.2_5'Flank|NBLA00301_uc010irh.2_5'Flank|NBLA00301_uc010iri.2_5'Flank|NBLA00301_uc010irj.2_5'Flank|NBLA00301_uc010irk.2_5'Flank|NBLA00301_uc010irl.2_5'Flank|NBLA00301_uc010irm.2_5'Flank|NBLA00301_uc010irn.2_5'Flank|NBLA00301_uc003itk.2_5'Flank|HAND2_uc003itg.1_Missense_Mutation_p.R89P|HAND2_uc010ire.1_Missense_Mutation_p.E124Q	NM_021973	NP_068808	P61296	HAND2_HUMAN	basic helix-loop-helix transcription factor	124	Helix-loop-helix motif.				adult heart development|angiogenesis|apoptosis|cardiac neural crest cell development involved in outflow tract morphogenesis|heart looping|in utero embryonic development|negative regulation of cardiac muscle cell apoptosis|noradrenergic neuron differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|regulation of secondary heart field cardioblast proliferation|thymus development	nuclear chromatin|transcription factor complex	activating transcription factor binding|protein homodimerization activity|RNA polymerase II regulatory region sequence-specific DNA binding|transcription coactivator activity			skin(1)	1		Prostate(90;0.00601)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0837)|all_hematologic(60;0.107)		all cancers(43;1.37e-18)|Epithelial(43;5.5e-17)|OV - Ovarian serous cystadenocarcinoma(60;3.3e-10)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		GGGATGCACTCGCGCAGTTCG	0.557		NaN											0	0	0	0.01441	0	44	131									
CCDC110	256309	broad.mit.edu	37	4	186379933	186379933	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr4:186379933C>T	uc003ixu.3	-	6	1884	c.1808G>A	c.(1807-1809)GGA>GAA	p.G603E	CCDC110_uc003ixv.3_Missense_Mutation_p.G566E|CCDC110_uc011ckt.1_Missense_Mutation_p.G603E	NM_152775	NP_689988	Q8TBZ0	CC110_HUMAN	coiled-coil domain containing 110 isoform a	603	Potential.					nucleus				central_nervous_system(1)	1		all_lung(41;1.3e-11)|Lung NSC(41;2.25e-11)|Melanoma(20;7.86e-05)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|Colorectal(36;0.0381)|all_hematologic(60;0.0749)		OV - Ovarian serous cystadenocarcinoma(60;1.13e-10)|BRCA - Breast invasive adenocarcinoma(30;8.01e-05)|GBM - Glioblastoma multiforme(59;0.00014)|STAD - Stomach adenocarcinoma(60;0.000777)|LUSC - Lung squamous cell carcinoma(40;0.00921)|COAD - Colon adenocarcinoma(29;0.0105)|READ - Rectum adenocarcinoma(43;0.164)		TAGTTCATTTCCAAGTGAGCT	0.323		NaN											0	0	0	0.016723	0	11	21									
CDH10	1008	broad.mit.edu	37	5	24491853	24491853	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr5:24491853C>G	uc003jgr.1	-	11	2040	c.1708G>C	c.(1708-1710)GAC>CAC	p.D570H	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	570	Cadherin 5.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		TAATCATTGTCTGATATCACC	0.413		NaN								HNSCC(23;0.051)			0	0	0	0.004672	0	3	45									
PDZD2	23037	broad.mit.edu	37	5	32074304	32074304	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr5:32074304C>T	uc003jhl.2	+	18	3480	c.3092C>T	c.(3091-3093)TCG>TTG	p.S1031L	PDZD2_uc003jhm.2_Missense_Mutation_p.S1031L|PDZD2_uc011cnx.1_Missense_Mutation_p.S857L	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	1031					cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						AAGGCCATCTCGGCACCTCTT	0.567		NaN											0	0	0	0.01441	0	54	28									
DHX29	54505	broad.mit.edu	37	5	54586091	54586091	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr5:54586091G>C	uc003jpx.2	-	7	982	c.862C>G	c.(862-864)CAA>GAA	p.Q288E	DHX29_uc010ivw.2_RNA	NM_019030	NP_061903	Q7Z478	DHX29_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 29	288	Potential.						ATP binding|ATP-dependent helicase activity|translation initiation factor activity			ovary(2)|central_nervous_system(1)|skin(1)	4		Lung NSC(810;4.08e-05)|Breast(144;0.0544)|Prostate(74;0.183)				TTTTGGCCTTGCTTGTTTTTT	0.328		NaN											0	0	0	0.004672	0	3	8									
DEPDC1B	55789	broad.mit.edu	37	5	59893730	59893730	+	Silent	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr5:59893730G>A	uc003jsh.2	-	11	1513	c.1440C>T	c.(1438-1440)TCC>TCT	p.S480S	DEPDC1B_uc011cqm.1_Silent_p.S418S|DEPDC1B_uc011cqn.1_Silent_p.S391S	NM_018369	NP_060839	Q8WUY9	DEP1B_HUMAN	DEP domain containing 1B isoform 1	480					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity			ovary(1)	1		Lung NSC(810;0.000214)|Prostate(74;0.0147)|Breast(144;0.0991)|Ovarian(174;0.17)				CTTCAGGATAGGATTTCTGAA	0.383		NaN											0	0	0	0.009096	0	4	11									
GCNT4	51301	broad.mit.edu	37	5	74324587	74324587	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr5:74324587C>G	uc003kdn.2	-	1	2138	c.1276G>C	c.(1276-1278)GAA>CAA	p.E426Q		NM_016591	NP_057675	Q9P109	GCNT4_HUMAN	core 2 beta-1,6-N-acetylglucosaminyltransferase	426	Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity			ovary(2)|skin(1)	3		all_lung(232;0.0131)|Lung NSC(167;0.0282)|Ovarian(174;0.0798)		OV - Ovarian serous cystadenocarcinoma(47;8.44e-57)		TCAAGCTTTTCTGCCAAGCAT	0.373		NaN											0	0	0	0.003163	0	13	25									
ANKRD32	84250	broad.mit.edu	37	5	94027275	94027275	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr5:94027275C>A	uc003kkr.3	+	19	2506	c.2426C>A	c.(2425-2427)ACA>AAA	p.T809K	ANKRD32_uc003kks.2_Missense_Mutation_p.T173K	NM_032290	NP_115666	Q9BQI6	ANR32_HUMAN	ankyrin repeat domain 32	809	ANK 1.									ovary(2)	2		all_cancers(142;1.51e-09)|all_epithelial(76;4.68e-12)|all_lung(232;5.94e-05)|Ovarian(174;0.000953)|Lung NSC(167;0.00105)|Colorectal(57;0.122)|Lung SC(612;0.152)		all cancers(79;3.88e-18)		GCAGGAGAAACAGCCCTGCAT	0.353		NaN											1	0	0.00621372	0.006214	0.00642651	7	22									
KCTD16	57528	broad.mit.edu	37	5	143587001	143587001	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr5:143587001G>A	uc003lnm.1	+	3	1353	c.724G>A	c.(724-726)GAG>AAG	p.E242K	KCTD16_uc003lnn.1_Missense_Mutation_p.E242K	NM_020768	NP_065819	Q68DU8	KCD16_HUMAN	potassium channel tetramerisation domain	242						cell junction|postsynaptic membrane|presynaptic membrane|voltage-gated potassium channel complex	voltage-gated potassium channel activity			large_intestine(2)|ovary(1)|skin(1)	4		all_hematologic(541;0.118)	KIRC - Kidney renal clear cell carcinoma(527;0.00111)|Kidney(363;0.00176)			TATGTTGTCAGAGTGTGGATT	0.428		NaN											0	0	0	0.012213	0	26	66									
SCGN	10590	broad.mit.edu	37	6	25665182	25665182	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:25665182G>A	uc003nfb.2	+	4	461	c.258G>A	c.(256-258)ATG>ATA	p.M86I	SCGN_uc010jpz.2_5'UTR	NM_006998	NP_008929	O76038	SEGN_HUMAN	secretagogin precursor	86	EF-hand 2.					extracellular region|transport vesicle membrane	calcium ion binding			ovary(2)|pancreas(1)	3						TTGCTGGTATGTTCTTATCTG	0.478		NaN											0	0	0	0.010504	0	15	38									
HIST1H2BO	8348	broad.mit.edu	37	6	27861555	27861555	+	Silent	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:27861555G>A	uc003nkc.1	+	1	353	c.315G>A	c.(313-315)GGG>GGA	p.G105G	HIST1H3J_uc003nka.2_5'Flank|HIST1H2AM_uc003nkb.1_5'Flank	NM_003527	NP_003518	P23527	H2B1O_HUMAN	histone cluster 1, H2bo	105					nucleosome assembly	nucleosome|nucleus	DNA binding				0						TGCTGCCCGGGGAGCTGGCCA	0.642		NaN											0	0	0	0.001984	0	4	114									
IER3	8870	broad.mit.edu	37	6	30712140	30712140	+	Silent	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:30712140G>A	uc003nrn.2	-	1	188	c.156C>T	c.(154-156)CCC>CCT	p.P52P	FLOT1_uc003nrm.2_5'Flank|FLOT1_uc011dmr.1_5'Flank	NM_003897	NP_003888	P46695	IEX1_HUMAN	immediate early response 3	52	Cytoplasmic (Potential).				anatomical structure morphogenesis|anti-apoptosis|apoptosis	integral to membrane	protein binding				0						GAGAGGCGCTGGGGCGCCCGG	0.731		NaN											0	0	0	0.004672	0	3	7									
PBX2	5089	broad.mit.edu	37	6	32155525	32155525	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:32155525C>T	uc003oav.1	-	5	1040	c.769G>A	c.(769-771)GAG>AAG	p.E257K	PBX2_uc003oaw.2_Missense_Mutation_p.E257K	NM_002586	NP_002577	P40425	PBX2_HUMAN	pre-B-cell leukemia homeobox 2	257	Homeobox; TALE-type.						transcription factor binding			ovary(1)	1						TTTAGGACCTCAGTGGCCTGT	0.527		NaN											0	0	0	0.00308	0	7	19									
TFAP2B	7021	broad.mit.edu	37	6	50791308	50791308	+	Silent	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:50791308C>T	uc003pag.2	+	2	436	c.270C>T	c.(268-270)AAC>AAT	p.N90N		NM_003221	NP_003212	Q92481	AP2B_HUMAN	transcription factor AP-2 beta	90	Gln/Pro-rich (transactivation domain).				nervous system development|positive regulation of transcription from RNA polymerase II promoter		protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0	Lung NSC(77;0.156)					CCCACGTCAACGACCCCTACT	0.672		NaN											0	0	0	0.012213	0	26	59									
HMGCLL1	54511	broad.mit.edu	37	6	55360317	55360317	+	Missense_Mutation	SNP	A	A	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:55360317A>T	uc003pcn.2	-	8	944	c.785T>A	c.(784-786)ATG>AAG	p.M262K	HMGCLL1_uc003pco.2_Missense_Mutation_p.M232K|HMGCLL1_uc010jzx.2_Missense_Mutation_p.M133K|HMGCLL1_uc011dxc.1_Missense_Mutation_p.M200K|HMGCLL1_uc011dxd.1_Missense_Mutation_p.M129K|HMGCLL1_uc011dxe.1_Intron	NM_019036	NP_061909	Q8TB92	HMGC2_HUMAN	3-hydroxymethyl-3-methylglutaryl-Coenzyme A	262							hydroxymethylglutaryl-CoA lyase activity|metal ion binding			skin(2)|ovary(1)|pancreas(1)	4	Lung NSC(77;0.0875)		LUSC - Lung squamous cell carcinoma(124;0.23)			ACTTTCCAACATTCTTTTCAT	0.443		NaN											0	0	0	0.007413	0	17	44									
GABRR2	2570	broad.mit.edu	37	6	90024839	90024839	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:90024839C>A	uc003pnb.2	-	1	129	c.121G>T	c.(121-123)GTT>TTT	p.V41F		NM_002043	NP_002034	P28476	GBRR2_HUMAN	gamma-aminobutyric acid (GABA) receptor, rho 2	41					synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity				0		all_cancers(76;1.67e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.49e-10)|all_hematologic(105;7.77e-07)|all_epithelial(107;2.51e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0158)		TCCACGAGAACCATCAAGCAA	0.473		NaN											1	0	9.53978e-28	0.01441	1.07501e-27	54	143									
MCHR2	84539	broad.mit.edu	37	6	100395738	100395738	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:100395738C>G	uc003pqh.1	-	3	607	c.292G>C	c.(292-294)GAG>CAG	p.E98Q	MCHR2_uc003pqi.1_Missense_Mutation_p.E98Q	NM_001040179	NP_001035269	Q969V1	MCHR2_HUMAN	melanin-concentrating hormone receptor 2	98	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	8		all_cancers(76;4.87e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0309)|Colorectal(196;0.069)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		AACACCCACTCTCCCCCTCGG	0.493		NaN											0	0	0	0.009096	0	4	130									
TSPYL1	7259	broad.mit.edu	37	6	116600209	116600209	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:116600209C>G	uc003pwp.3	-	1	1072	c.785G>C	c.(784-786)CGA>CCA	p.R262P	DSE_uc011ebf.1_Intron|DSE_uc003pwq.1_5'Flank|DSE_uc003pwr.2_5'Flank|DSE_uc003pws.2_5'Flank	NM_003309	NP_003300	Q9H0U9	TSYL1_HUMAN	TSPY-like 1	262					nucleosome assembly	nucleolus					0		all_cancers(87;0.0144)|all_epithelial(87;0.021)|Colorectal(196;0.234)		all cancers(137;0.0235)|OV - Ovarian serous cystadenocarcinoma(136;0.0469)|GBM - Glioblastoma multiforme(226;0.0503)|Epithelial(106;0.094)		CAGGTAGTGTCGACGCATCCG	0.567		NaN											0	0	0	0.015359	0	29	110									
AKAP7	9465	broad.mit.edu	37	6	131490373	131490373	+	Silent	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:131490373G>A	uc003qck.2	+	5	582	c.549G>A	c.(547-549)CTG>CTA	p.L183L	AKAP7_uc011ebz.1_Silent_p.L161L|AKAP7_uc003qcl.1_Silent_p.L64L	NM_016377	NP_057461	O43687	AKA7A_HUMAN	A-kinase anchor protein 7 isoform gamma	Error:Variant_position_missing_in_O43687_after_alignment					intracellular signal transduction|ion transport	apical plasma membrane|intracellular|lateral plasma membrane	protein kinase A binding			ovary(2)	2	Breast(56;0.152)			GBM - Glioblastoma multiforme(226;0.0184)|OV - Ovarian serous cystadenocarcinoma(155;0.0345)		TTGTGAAGCTGGCAGAAGGAG	0.378		NaN											0	0	0	0.007835	0	34	102									
TCP10L2	401285	broad.mit.edu	37	6	167590518	167590518	+	Silent	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr6:167590518C>T	uc010kkp.2	+	4	525	c.394C>T	c.(394-396)CTG>TTG	p.L132L		NM_001145121	NP_001138593	B9ZVM9	B9ZVM9_HUMAN	t-complex 10-like 2	132											0						AATTTCACCTCTGTCAGCTGA	0.418		NaN											0	0	0	0.008871	0	12	43									
DNAH11	8701	broad.mit.edu	37	7	21695538	21695538	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr7:21695538G>C	uc003svc.2	+	29	5079	c.5048G>C	c.(5047-5049)GGA>GCA	p.G1683A		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	1683	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						AGGGCAGTTGGAATGTACAGC	0.428		NaN							Kartagener_syndrome				0	0	0	0.009096	0	4	35									
PKD1L1	168507	broad.mit.edu	37	7	47832313	47832313	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr7:47832313G>C	uc003tny.1	-	56	8438	c.8438C>G	c.(8437-8439)CCC>CGC	p.P2813R	C7orf69_uc003tnz.3_5'Flank|C7orf69_uc003toa.1_5'Flank	NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	2813	Cytoplasmic (Potential).				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						TTCCAGAAGGGGGAGTTGTAG	0.428		NaN											0	0	0	0.008361	0	27	64									
SPDYE5	442590	broad.mit.edu	37	7	75130883	75130883	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr7:75130883G>A	uc011kfy.1	+	6	894	c.758G>A	c.(757-759)CGT>CAT	p.R253H		NM_001099435	NP_001092905	A6NIY4	SPDE5_HUMAN	speedy homolog E5	253	Arg-rich.										0						CAGTTAGGCCGTTCCATGAAC	0.592		NaN											0	0	0	0.004482	0	6	239									
CROT	54677	broad.mit.edu	37	7	87011302	87011302	+	Missense_Mutation	SNP	G	G	C			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr7:87011302G>C	uc003uit.2	+	11	1300	c.1055G>C	c.(1054-1056)AGA>ACA	p.R352T	CROT_uc003uiu.2_Missense_Mutation_p.R380T	NM_021151	NP_066974	Q9UKG9	OCTC_HUMAN	peroxisomal carnitine O-octanoyltransferase	352					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity			ovary(2)|lung(1)	3	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)	AATGAAGGAAGATGGAAGGTA	0.303		NaN											0	0	0	0.009096	0	4	31									
CASD1	64921	broad.mit.edu	37	7	94164632	94164632	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr7:94164632G>A	uc003uni.3	+	8	867	c.640G>A	c.(640-642)GAA>AAA	p.E214K	CASD1_uc003unh.2_Intron|CASD1_uc003unj.3_Missense_Mutation_p.E214K	NM_022900	NP_075051	Q96PB1	CASD1_HUMAN	CAS1 domain containing 1 precursor	214						integral to membrane				ovary(2)	2	all_cancers(62;6.71e-10)|all_epithelial(64;5e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			TCCTGTTTATGAAGATCTATT	0.328		NaN											0	0	0	0.004007	0	14	42									
TAF6	6878	broad.mit.edu	37	7	99709745	99709745	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr7:99709745C>T	uc003uti.2	-	7	787	c.706G>A	c.(706-708)GAG>AAG	p.E236K	TAF6_uc003utg.2_Missense_Mutation_p.E158K|TAF6_uc003uth.2_Missense_Mutation_p.E293K|TAF6_uc003utk.2_Missense_Mutation_p.E236K|TAF6_uc011kji.1_Missense_Mutation_p.E273K|TAF6_uc003utj.2_Missense_Mutation_p.E226K|TAF6_uc003utl.2_Missense_Mutation_p.E236K|TAF6_uc003utm.2_Missense_Mutation_p.E236K|TAF6_uc003utn.1_RNA	NM_139315	NP_647476	P49848	TAF6_HUMAN	TBP-associated factor 6 isoform alpha	236					negative regulation of cell cycle|negative regulation of cell proliferation|regulation of sequence-specific DNA binding transcription factor activity|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	cytoplasm|MLL1 complex|transcription factor TFIID complex|transcription factor TFIID complex|transcription factor TFTC complex	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)|central_nervous_system(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					CTCTTGGCCTCGCAGGAGCCC	0.672		NaN											0	0	0	0.00308	0	7	12									
ZNF282	8427	broad.mit.edu	37	7	148895819	148895819	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr7:148895819C>T	uc003wfm.2	+	2	665	c.560C>T	c.(559-561)CCG>CTG	p.P187L	ZNF282_uc011kun.1_Missense_Mutation_p.P187L|ZNF282_uc003wfn.2_Missense_Mutation_p.P127L|ZNF282_uc003wfo.2_Missense_Mutation_p.P127L	NM_003575	NP_003566	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	187					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		CGGCTGCCCCCGGGCAGCAAG	0.597		NaN											0	0	0	0.016723	0	10	64									
DOCK5	80005	broad.mit.edu	37	8	25174557	25174557	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr8:25174557C>G	uc003xeg.2	+	14	1490	c.1353C>G	c.(1351-1353)ATC>ATG	p.I451M	DOCK5_uc010luf.1_RNA|DOCK5_uc003xeh.1_Missense_Mutation_p.I165M|DOCK5_uc003xei.2_Missense_Mutation_p.I21M	NM_024940	NP_079216	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	451	DHR-1.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)	3		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		TCACCCTGATCCACGGTGAGT	0.478		NaN											0	0	0	0.004672	0	3	53									
CER1	9350	broad.mit.edu	37	9	14720234	14720234	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr9:14720234G>A	uc003zlj.2	-	2	703	c.658C>T	c.(658-660)CCA>TCA	p.P220S		NM_005454	NP_005445	O95813	CER1_HUMAN	cerberus 1 precursor	220	CTCK.				BMP signaling pathway	extracellular space	cytokine activity				0				GBM - Glioblastoma multiforme(50;3.16e-06)		CAGTTCAGTGGCAAGTGCATC	0.542		NaN											0	0	0	0.00308	0	5	134									
C9orf64	84267	broad.mit.edu	37	9	86571110	86571110	+	Silent	SNP	C	C	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr9:86571110C>A	uc004anb.2	-	1	554	c.306G>T	c.(304-306)CTG>CTT	p.L102L	C9orf64_uc004anc.2_5'UTR	NM_032307	NP_115683	Q5T6V5	CI064_HUMAN	hypothetical protein LOC84267	102											0						CGGCGGCGCACAGGGACCAGT	0.552		NaN											1	0	3.66854e-30	0.007835	4.19659e-30	30	137									
IKBKAP	8518	broad.mit.edu	37	9	111663910	111663910	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr9:111663910C>T	uc004bdm.3	-	17	2426	c.1906G>A	c.(1906-1908)GAG>AAG	p.E636K	IKBKAP_uc004bdl.2_Missense_Mutation_p.E287K|IKBKAP_uc011lwc.1_Missense_Mutation_p.E522K|IKBKAP_uc010mtq.2_Missense_Mutation_p.E287K	NM_003640	NP_003631	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene	636					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	7						CTTGATACCTCAATGTCATTG	0.433		NaN											0	0	0	0.007413	0	16	51									
SHOX	6473	broad.mit.edu	37	X	591697	591697	+	Missense_Mutation	SNP	G	G	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chrX:591697G>A	uc004cph.1	+	2	756	c.65G>A	c.(64-66)GGA>GAA	p.G22E	SHOX_uc004cpi.2_Missense_Mutation_p.G22E	NM_000451	NP_000442	O15266	SHOX_HUMAN	short stature homeobox isoform SHOXa	22	Poly-Gly.				skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GGTAACGGCGGAGGCGGAGGC	0.627		NaN											0	0	0	0.014758	0	5	220									
IRS4	8471	broad.mit.edu	37	X	107977994	107977994	+	Missense_Mutation	SNP	C	C	A			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chrX:107977994C>A	uc004eoc.2	-	1	1614	c.1581G>T	c.(1579-1581)CAG>CAT	p.Q527H		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	527						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						CTCGGGATCCCTGTCCCTCGC	0.632		NaN											1	0	1.10513e-12	0.014323	1.20924e-12	17	133									
IRS4	8471	broad.mit.edu	37	X	107977998	107977998	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chrX:107977998C>T	uc004eoc.2	-	1	1610	c.1577G>A	c.(1576-1578)GGA>GAA	p.G526E		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	526						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						GGATCCCTGTCCCTCGCCTGA	0.632		NaN											0	0	0	0.012319	0	16	130									
IRS4	8471	broad.mit.edu	37	X	107978050	107978050	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chrX:107978050C>T	uc004eoc.2	-	1	1558	c.1525G>A	c.(1525-1527)GGC>AGC	p.G509S		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	509						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						GAGCCTTGGCCATTTGAGCCC	0.597		NaN											0	0	0	0.020292	0	10	93									
IRS4	8471	broad.mit.edu	37	X	107978105	107978105	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chrX:107978105C>G	uc004eoc.2	-	1	1503	c.1470G>C	c.(1468-1470)ATG>ATC	p.M490I		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	490	YXXM motif 1.					plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						CCCAATTGTTCATAGGCATGT	0.562		NaN											0	0	0	0.016723	0	9	82									
IRS4	8471	broad.mit.edu	37	X	107978119	107978119	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chrX:107978119C>T	uc004eoc.2	-	1	1489	c.1456G>A	c.(1456-1458)GAC>AAC	p.D486N		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	486						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						GGCATGTAGTCACCTCCGCTT	0.577		NaN											0	0	0	0.004482	0	7	78									
IRS4	8471	broad.mit.edu	37	X	107978140	107978140	+	Missense_Mutation	SNP	C	C	G			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chrX:107978140C>G	uc004eoc.2	-	1	1468	c.1435G>C	c.(1435-1437)GAT>CAT	p.D479H		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	479						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						CCTTCCTGATCTTCTTTGCCC	0.577		NaN											0	0	0	0.010729	0	9	64									
IRS4	8471	broad.mit.edu	37	X	107978233	107978233	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chrX:107978233C>T	uc004eoc.2	-	1	1375	c.1342G>A	c.(1342-1344)GAA>AAA	p.E448K		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	448						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						TTCGGGGCTTCTGCAGGGTGC	0.612		NaN											0	0	0	0.001168	0	6	59									
GDI1	2664	broad.mit.edu	37	X	153668396	153668396	+	Missense_Mutation	SNP	C	C	T			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chrX:153668396C>T	uc004fli.3	+	5	839	c.497C>T	c.(496-498)ACC>ATC	p.T166I	GDI1_uc011mzo.1_Missense_Mutation_p.T166I|GDI1_uc004flj.2_5'Flank	NM_001493	NP_001484	P31150	GDIA_HUMAN	GDP dissociation inhibitor 1	166					protein transport|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|midbody	GTPase activator activity|protein binding				0	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CCCCAGACTACCAGCATGCGT	0.552		NaN											0	0	0	0.004482	0	6	290									
EFCAB4A	283229	broad.mit.edu	37	11	831640	831642	+	In_Frame_Del	DEL	CTG	CTG	-			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr11:831640_831642delCTG	uc001lrv.2	+	9	1509_1511	c.1131_1133delCTG	c.(1129-1134)ACCTGC>ACC	p.C383del	EFCAB4A_uc009ycm.1_3'UTR|EFCAB4A_uc001lrw.2_In_Frame_Del_p.C448del|CD151_uc001lrx.2_5'Flank|CD151_uc001lry.2_5'Flank|CD151_uc001lrz.2_5'Flank|CD151_uc001lsa.2_5'Flank|CD151_uc001lsb.2_5'Flank			Q8N4Y2	EFC4A_HUMAN	RecName: Full=EF-hand calcium-binding domain-containing protein 4A;	383	Cys-rich.				store-operated calcium entry		calcium ion binding				0		all_cancers(49;2.31e-08)|all_epithelial(84;3.72e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.179)|all_lung(207;0.227)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		CTGGGCCCACCTGCTGCTGCTGC	0.695		NaN											NaN	NaN	NaN	NaN	NaN	3	5	---	---							
ADAMTS2	9509	broad.mit.edu	37	5	178772259	178772260	+	In_Frame_Ins	INS	-	-	GCA			TCGA-DK-A3IV-01A-22D-A21A-08	TCGA-DK-A3IV-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7cecfbbc-5fe4-4413-95fd-07533aacbb73	e7fdb6f5-7d5a-4f7f-b1bb-48481bfca5a2	g.chr5:178772259_178772260insGCA	uc003mjw.2	-	1	70_71	c.70_71insTGC	c.(70-72)CCG>CTGCCG	p.23_24insL	ADAMTS2_uc011dgm.1_In_Frame_Ins_p.23_24insL	NM_014244	NP_055059	O95450	ATS2_HUMAN	ADAM metallopeptidase with thrombospondin type 1	23_24					collagen catabolic process	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	all_cancers(89;0.000456)|all_epithelial(37;0.000138)|Renal(175;0.000159)|Lung NSC(126;0.00184)|all_lung(126;0.00326)	all_cancers(40;0.00604)|all_neural(177;0.00411)|Medulloblastoma(196;0.00508)|Lung NSC(249;0.0569)|all_lung(500;0.129)|all_hematologic(541;0.211)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	GBM - Glioblastoma multiforme(465;0.0473)		gagcggcggcggcagcagcagc	0.584		NaN											NaN	NaN	NaN	NaN	NaN	5	4	---	---							
