Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	isArtifactMode	oxoGCut	pox	pox_cutoff	qox	t_alt_count	t_ref_count	validation_alt_allele	validation_tumor_sample							
TTLL10	254173	broad.mit.edu	37	1	1120466	1120466	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:1120466G>C	uc001acy.2	+	13	1529	c.1378G>C	c.(1378-1380)GAC>CAC	p.D460H	TTLL10_uc010nyg.1_Missense_Mutation_p.D460H|TTLL10_uc001acz.1_Missense_Mutation_p.D387H	NM_001130045	NP_001123517	Q6ZVT0	TTL10_HUMAN	tubulin tyrosine ligase-like family, member 10	460	TTL.				protein modification process		ATP binding|tubulin-tyrosine ligase activity			large_intestine(1)	1	all_cancers(77;0.00164)|all_epithelial(69;0.000959)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;9.48e-15)|all_lung(118;9.67e-07)|Lung NSC(185;5.59e-05)|Renal(390;0.00571)|Breast(487;0.0183)|Hepatocellular(190;0.0268)|Myeloproliferative disorder(586;0.028)|Ovarian(437;0.127)|Lung SC(97;0.217)		Epithelial(90;4.75e-36)|OV - Ovarian serous cystadenocarcinoma(86;5.82e-22)|Colorectal(212;3.94e-05)|COAD - Colon adenocarcinoma(227;4.22e-05)|Kidney(185;0.00227)|BRCA - Breast invasive adenocarcinoma(365;0.00461)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0339)|Lung(427;0.199)		CCTCGCCAAGGACTGGGTCTT	0.632		NaN											0	0	0	0.000978	0	10	20									
CHD5	26038	broad.mit.edu	37	1	6206323	6206323	+	Missense_Mutation	SNP	C	C	T	rs141210110		TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:6206323C>T	uc001amb.1	-	11	1851	c.1751G>A	c.(1750-1752)CGC>CAC	p.R584H	CHD5_uc001ama.1_5'Flank|CHD5_uc001amc.1_RNA	NM_015557	NP_056372	Q8TDI0	CHD5_HUMAN	chromodomain helicase DNA binding protein 5	584					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ATP binding|ATP-dependent helicase activity|DNA binding|zinc ion binding			central_nervous_system(3)|breast(3)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	12	Ovarian(185;0.0634)	all_cancers(23;5.36e-32)|all_epithelial(116;2.32e-17)|all_neural(13;3.68e-06)|all_lung(118;3.94e-06)|all_hematologic(16;2.39e-05)|Lung NSC(185;5.33e-05)|Acute lymphoblastic leukemia(12;0.000372)|Glioma(11;0.00127)|Renal(390;0.00188)|Colorectal(325;0.00342)|Breast(487;0.00373)|Hepatocellular(190;0.0218)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.15)		Epithelial(90;3.08e-37)|GBM - Glioblastoma multiforme(13;1.36e-31)|OV - Ovarian serous cystadenocarcinoma(86;7.7e-19)|Colorectal(212;9.97e-08)|COAD - Colon adenocarcinoma(227;1.07e-05)|Kidney(185;6.16e-05)|KIRC - Kidney renal clear cell carcinoma(229;0.00109)|BRCA - Breast invasive adenocarcinoma(365;0.0012)|STAD - Stomach adenocarcinoma(132;0.00346)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.193)		GATGCCATAGCGGTAGAAGCG	0.607		NaN											0	0	0	0.003954	0	22	66									
SPEN	23013	broad.mit.edu	37	1	16255003	16255003	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:16255003C>G	uc001axk.1	+	11	2472	c.2268C>G	c.(2266-2268)TAC>TAG	p.Y756*	SPEN_uc010obp.1_Nonsense_Mutation_p.Y715*	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	756	Arg-rich.				interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		GGAGGCTTTACAGCCGATCCT	0.512		NaN											0	0	0	0.004656	0	27	65									
ZBTB8A	653121	broad.mit.edu	37	1	33059171	33059171	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:33059171G>C	uc001bvn.2	+	3	1124	c.639G>C	c.(637-639)TTG>TTC	p.L213F	ZBTB8A_uc001bvk.2_RNA|ZBTB8A_uc001bvm.2_Missense_Mutation_p.L213F	NM_001040441	NP_001035531	Q96BR9	ZBT8A_HUMAN	zinc finger and BTB domain containing 8A	213					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCAAACATTTGAGATTGTCAC	0.403		NaN											0	0	0	0.000978	0	12	38									
ZSCAN20	7579	broad.mit.edu	37	1	33957212	33957212	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:33957212G>A	uc001bxj.3	+	6	1521	c.1354G>A	c.(1354-1356)GAA>AAA	p.E452K	ZSCAN20_uc001bxk.2_Missense_Mutation_p.E398K|ZSCAN20_uc009vui.2_Missense_Mutation_p.E452K	NM_145238	NP_660281	P17040	ZSC20_HUMAN	zinc finger protein 31	452					viral reproduction	mitochondrion|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.211)				AGAAATGGCAGAAGACTGTAA	0.577		NaN											0	0	0	0.002445	0	32	55									
C1orf94	84970	broad.mit.edu	37	1	34663406	34663406	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:34663406C>T	uc001bxs.3	+	2	730	c.331C>T	c.(331-333)CCT>TCT	p.P111S	C1orf94_uc001bxt.2_Missense_Mutation_p.P301S	NM_032884	NP_116273	Q6P1W5	CA094_HUMAN	hypothetical protein LOC84970 isoform b	111							protein binding				0		Myeloproliferative disorder(586;0.0393)				TCCTGCACGTCCTGACAAGCT	0.612		NaN											0	0	0	0.007413	0	18	40									
ARTN	9048	broad.mit.edu	37	1	44402240	44402240	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:44402240C>T	uc001cks.2	+	5	1248	c.466C>T	c.(466-468)CGC>TGC	p.R156C	ARTN_uc001ckv.2_Missense_Mutation_p.R164C|ARTN_uc001ckt.2_Missense_Mutation_p.R164C|ARTN_uc001cku.2_Missense_Mutation_p.R156C|ARTN_uc001ckw.2_Missense_Mutation_p.R173C	NM_057091	NP_476432	Q5T4W7	ARTN_HUMAN	neurotrophic factor artemin isoform 1 precursor	156					axon guidance|neuroblast proliferation|signal transduction	extracellular region	growth factor activity				0	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)				CTCCTGCCGCCGCGCGCGCTC	0.776		NaN											0	0	0	0.000248	0	4	4									
PLK3	1263	broad.mit.edu	37	1	45269884	45269884	+	Missense_Mutation	SNP	T	T	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:45269884T>G	uc001cmn.2	+	11	1408	c.1308T>G	c.(1306-1308)TGT>TGG	p.C436W	PLK3_uc001cmo.2_RNA	NM_004073	NP_004064	Q9H4B4	PLK3_HUMAN	polo-like kinase 3	436						membrane	ATP binding|protein binding|protein serine/threonine kinase activity				0	Acute lymphoblastic leukemia(166;0.155)					CAGCCCTTTGTGCTCTGAGAA	0.552		NaN											0	0	0	0.006122	0	19	35									
DNAJC6	9829	broad.mit.edu	37	1	65874363	65874363	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:65874363C>G	uc001dcd.1	+	17	2524	c.2360C>G	c.(2359-2361)TCT>TGT	p.S787C	DNAJC6_uc010opc.1_Missense_Mutation_p.S774C|DNAJC6_uc001dce.1_Missense_Mutation_p.S844C	NM_014787	NP_055602	O75061	AUXI_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 6	787					cellular membrane organization|post-Golgi vesicle-mediated transport	cytosol	heat shock protein binding|protein tyrosine phosphatase activity|SH3 domain binding			large_intestine(1)|lung(1)|ovary(1)	3						GACCTACTCTCTGGTCAAGGT	0.368		NaN											0	0	0	0.001882	0	21	56									
DDAH1	23576	broad.mit.edu	37	1	85816110	85816110	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:85816110C>G	uc001dlb.2	-	4	746	c.585G>C	c.(583-585)CAG>CAC	p.Q195H	DDAH1_uc001dlc.2_Missense_Mutation_p.Q92H|uc001dla.1_Intron|DDAH1_uc010osb.1_Missense_Mutation_p.Q95H|DDAH1_uc009wco.2_Missense_Mutation_p.Q92H	NM_012137	NP_036269	O94760	DDAH1_HUMAN	dimethylarginine dimethylaminohydrolase 1	195					arginine catabolic process|citrulline metabolic process|nitric oxide mediated signal transduction		dimethylargininase activity|metal ion binding				0				all cancers(265;0.0318)|Epithelial(280;0.0657)	L-Citrulline(DB00155)	TAAGGGCCTTCTGTGCAGATT	0.502		NaN											0	0	0	0.00361	0	49	95									
RBM15	64783	broad.mit.edu	37	1	110882243	110882243	+	Silent	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:110882243G>A	uc001dzl.1	+	1	299	c.216G>A	c.(214-216)AAG>AAA	p.K72K	RBM15_uc001dzm.1_Silent_p.K72K|uc001dzj.2_5'Flank	NM_022768	NP_073605	Q96T37	RBM15_HUMAN	RNA binding motif protein 15	72	Gly/Ser-rich.				interspecies interaction between organisms	nucleus	nucleotide binding|protein binding|RNA binding			ovary(3)	3		all_cancers(81;2.89e-06)|all_epithelial(167;2.96e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)|Breast(1374;0.0634)		BRCA - Breast invasive adenocarcinoma(282;0.000224)|Epithelial(280;0.000476)|Kidney(133;0.000539)|KIRC - Kidney renal clear cell carcinoma(1967;0.000716)|all cancers(265;0.00144)|Lung(183;0.0238)|Colorectal(144;0.103)|LUSC - Lung squamous cell carcinoma(189;0.135)		AGCGGAGCAAGAAGTTAGGGG	0.632		NaN	T	MKL1	acute megakaryocytic leukemia								0	0	0	0.006122	0	17	26									
NOTCH2NL	388677	broad.mit.edu	37	1	145281697	145281697	+	Silent	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:145281697C>T	uc001emn.3	+	4	997	c.627C>T	c.(625-627)TGC>TGT	p.C209C	NBPF10_uc009wir.2_Intron|NBPF9_uc010oye.1_Intron|NBPF9_uc010oyf.1_Intron|NBPF9_uc010oyg.1_Intron|NBPF10_uc001emp.3_5'UTR|NOTCH2NL_uc001emm.3_Silent_p.C209C|NOTCH2NL_uc001emo.2_Silent_p.C209C|NOTCH2NL_uc010oyh.1_RNA	NM_203458	NP_982283	Q7Z3S9	NT2NL_HUMAN	Notch homolog 2 N-terminal like protein	209	EGF-like 6.				cell differentiation|multicellular organismal development|Notch signaling pathway	cytoplasm|extracellular region	calcium ion binding			ovary(1)	1						AGTGCAACTGCCTTCCAGGTA	0.542		NaN											0	0	0	0.006214	0	9	127									
FMO5	2330	broad.mit.edu	37	1	146672821	146672821	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:146672821G>C	uc001epi.2	-	7	1485	c.1096C>G	c.(1096-1098)CTT>GTT	p.L366V	FMO5_uc001eph.3_Missense_Mutation_p.L366V|FMO5_uc001epj.2_Intron	NM_001461	NP_001452	P49326	FMO5_HUMAN	flavin containing monooxygenase 5 isoform 1	366						integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			ovary(3)	3	all_hematologic(923;0.0487)					ATGATTGCAAGAGTTGGCCTT	0.453		NaN											0	0	0	0.00245	0	14	33									
FMO5	2330	broad.mit.edu	37	1	146672902	146672902	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:146672902G>C	uc001epi.2	-	7	1404	c.1015C>G	c.(1015-1017)CTG>GTG	p.L339V	FMO5_uc001eph.3_Missense_Mutation_p.L339V|FMO5_uc001epj.2_Intron	NM_001461	NP_001452	P49326	FMO5_HUMAN	flavin containing monooxygenase 5 isoform 1	339						integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			ovary(3)	3	all_hematologic(923;0.0487)					GAATCTTCCAGAAACGGAAAG	0.448		NaN											0	0	0	0.007413	0	18	51									
ACP6	51205	broad.mit.edu	37	1	147124335	147124335	+	Silent	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:147124335G>A	uc001epr.2	-	7	1262	c.798C>T	c.(796-798)AGC>AGT	p.S266S	ACP6_uc009wjj.1_3'UTR	NM_016361	NP_057445	Q9NPH0	PPA6_HUMAN	acid phosphatase 6, lysophosphatidic precursor	266					lipid metabolic process	extracellular region|mitochondrion	acid phosphatase activity|protein binding			ovary(4)	4	all_hematologic(923;0.0276)					GCATGGGGCAGCTTGGGAGGT	0.493		NaN											0	0	0	0.003954	0	23	49									
MCL1	4170	broad.mit.edu	37	1	150551448	150551448	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:150551448G>A	uc001euz.2	-	1	689	c.559C>T	c.(559-561)CGG>TGG	p.R187W	MCL1_uc010pch.1_Missense_Mutation_p.R77W|MCL1_uc001eva.2_Missense_Mutation_p.R187W	NM_021960	NP_068779	Q07820	MCL1_HUMAN	myeloid cell leukemia sequence 1 isoform 1	187					anti-apoptosis|apoptosis|cell fate determination|cellular homeostasis|multicellular organismal development|response to cytokine stimulus	integral to membrane|mitochondrial outer membrane|nucleoplasm	BH3 domain binding|protein binding|protein channel activity|protein heterodimerization activity				0	all_cancers(9;1.69e-53)|all_epithelial(9;1.95e-43)|all_lung(15;1.09e-34)|Lung NSC(24;4.04e-31)|Breast(34;0.000326)|Lung SC(34;0.00471)|Ovarian(49;0.0167)|all_hematologic(923;0.0395)|Hepatocellular(266;0.108)|Melanoma(130;0.128)|Colorectal(459;0.171)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0241)|Epithelial(6;3.18e-23)|all cancers(9;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(6;1.13e-14)|BRCA - Breast invasive adenocarcinoma(12;0.000503)|LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.206)			GCCTGCTCCCGAAGGTACCGA	0.647		NaN											0	0	0	0.003954	0	24	50									
TNFAIP8L2	79626	broad.mit.edu	37	1	151131260	151131260	+	Silent	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:151131260C>G	uc001ewx.2	+	2	213	c.87C>G	c.(85-87)CTC>CTG	p.L29L		NM_024575	NP_078851	Q6P589	TP8L2_HUMAN	tumor necrosis factor, alpha-induced protein	29					innate immune response						0	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TGGCTCATCTCTTCATAGATG	0.567		NaN											0	0	0	0.004656	0	24	34									
HRNR	388697	broad.mit.edu	37	1	152188523	152188523	+	Missense_Mutation	SNP	T	T	C	rs140946102		TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:152188523T>C	uc001ezt.1	-	3	5658	c.5582A>G	c.(5581-5583)CAT>CGT	p.H1861R		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	1861	20.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCCAGACCCATGTCGGCCACT	0.592		NaN											0	0	0	0.00361	0	46	519									
IVL	3713	broad.mit.edu	37	1	152882414	152882414	+	Silent	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:152882414G>A	uc001fau.2	+	2	187	c.141G>A	c.(139-141)GTG>GTA	p.V47V		NM_005547	NP_005538	P07476	INVO_HUMAN	involucrin	47					isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|keratinization|response to UV-B	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			ovary(3)	3	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCCAGAAGGTGCCTGTCGAGC	0.502		NaN											0	0	0	0.004482	0	7	44									
YY1AP1	55249	broad.mit.edu	37	1	155649255	155649255	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:155649255C>T	uc001fln.2	-	4	292	c.268G>A	c.(268-270)GAG>AAG	p.E90K	YY1AP1_uc010pgg.1_5'Flank|YY1AP1_uc010pgh.1_Missense_Mutation_p.E13K|YY1AP1_uc010pgi.1_Missense_Mutation_p.E162K|YY1AP1_uc001flh.2_Missense_Mutation_p.E162K|YY1AP1_uc009wqt.2_Missense_Mutation_p.E13K|YY1AP1_uc001flk.2_Missense_Mutation_p.E13K|YY1AP1_uc001fll.2_Missense_Mutation_p.E24K|YY1AP1_uc009wqv.2_5'UTR|YY1AP1_uc001flm.2_Missense_Mutation_p.E13K|YY1AP1_uc001fli.2_Missense_Mutation_p.E24K|YY1AP1_uc009wqu.2_5'UTR|YY1AP1_uc001flj.2_Missense_Mutation_p.E24K|YY1AP1_uc009wqw.2_Missense_Mutation_p.E13K|YY1AP1_uc001flo.2_5'UTR|YY1AP1_uc001flp.2_Missense_Mutation_p.E24K|YY1AP1_uc010pgj.1_Missense_Mutation_p.E90K|YY1AP1_uc009wqx.2_Missense_Mutation_p.E162K|YY1AP1_uc010pgk.1_Missense_Mutation_p.E162K	NM_139118	NP_620829	Q9H869	YYAP1_HUMAN	YY1-associated protein isoform 2	90					regulation of cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)|skin(1)	3	Hepatocellular(266;0.0997)|all_hematologic(923;0.145)					CGCTCCTCCTCTTCTGGGCCA	0.483		NaN											0	0	0	0.003163	0	16	52									
RGL1	23179	broad.mit.edu	37	1	183853949	183853949	+	Silent	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:183853949C>T	uc001gqo.2	+	7	985	c.828C>T	c.(826-828)ATC>ATT	p.I276I	RGL1_uc010pof.1_Silent_p.I81I|RGL1_uc001gqm.2_Silent_p.I311I|RGL1_uc010pog.1_Silent_p.I274I|RGL1_uc010poh.1_Silent_p.I274I|RGL1_uc010poi.1_Silent_p.I276I	NM_015149	NP_055964	Q9NZL6	RGL1_HUMAN	ral guanine nucleotide dissociation	276	Ras-GEF.				cellular lipid metabolic process|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	intracellular	protein binding|Ral guanyl-nucleotide exchange factor activity			breast(5)|ovary(4)|lung(2)	11						CTCCTACGATCCGTGCCACCA	0.478		NaN											0	0	0	0.007413	0	19	39									
PRG4	10216	broad.mit.edu	37	1	186280724	186280724	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:186280724G>C	uc001gru.3	+	10	3840	c.3789G>C	c.(3787-3789)AAG>AAC	p.K1263N	PRG4_uc001grt.3_Missense_Mutation_p.K1222N|PRG4_uc009wyl.2_Missense_Mutation_p.K1170N|PRG4_uc009wym.2_Missense_Mutation_p.K1129N|PRG4_uc010poo.1_RNA	NM_005807	NP_005798	Q92954	PRG4_HUMAN	proteoglycan 4 isoform A	1263					cell proliferation|immune response	extracellular region	polysaccharide binding|protein binding|scavenger receptor activity			skin(1)	1						ATTTTTTCAAGAGAGGTATGT	0.313		NaN											0	0	0	0.003954	0	23	44									
PTPRC	5788	broad.mit.edu	37	1	198668734	198668734	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:198668734G>A	uc001gur.1	+	5	514	c.334G>A	c.(334-336)GAC>AAC	p.D112N	PTPRC_uc001gus.1_Missense_Mutation_p.D112N|PTPRC_uc001gut.1_Intron|PTPRC_uc009wze.1_Missense_Mutation_p.D48N|PTPRC_uc009wzf.1_Missense_Mutation_p.D48N|PTPRC_uc010ppg.1_Missense_Mutation_p.D48N|PTPRC_uc001guu.1_Missense_Mutation_p.D155N|PTPRC_uc001guv.1_RNA|PTPRC_uc001guw.1_RNA	NM_002838	NP_002829	P08575	PTPRC_HUMAN	protein tyrosine phosphatase, receptor type, C	112	Extracellular (Potential).				axon guidance|B cell proliferation|B cell receptor signaling pathway|defense response to virus|immunoglobulin biosynthetic process|negative regulation of cytokine-mediated signaling pathway|negative regulation of protein kinase activity|negative regulation of T cell mediated cytotoxicity|positive regulation of antigen receptor-mediated signaling pathway|positive regulation of B cell proliferation|positive regulation of protein kinase activity|positive regulation of T cell proliferation|regulation of S phase|release of sequestered calcium ion into cytosol|T cell differentiation|T cell receptor signaling pathway	focal adhesion|integral to plasma membrane|membrane raft	protein kinase binding|transmembrane receptor protein tyrosine phosphatase activity			breast(4)|skin(3)|ovary(2)|lung(1)|kidney(1)|pancreas(1)	12						CACGCACGCAGACTCGCAGAC	0.527		NaN									OREG0014061	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.00623	0	40	97									
KIF14	9928	broad.mit.edu	37	1	200550392	200550392	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:200550392G>A	uc010ppk.1	-	20	3711	c.3272C>T	c.(3271-3273)TCA>TTA	p.S1091L	KIF14_uc010ppj.1_Missense_Mutation_p.S600L	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14	1091	Required for CIT-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7						AATCATCATTGAGAGTTTCAT	0.328		NaN											0	0	0	0.00361	0	45	79									
PHLDA3	23612	broad.mit.edu	37	1	201437713	201437713	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:201437713C>A	uc001gwq.2	-	1	587	c.202G>T	c.(202-204)GGG>TGG	p.G68W	PHLDA3_uc009wzx.2_5'UTR	NM_012396	NP_036528	Q9Y5J5	PHLA3_HUMAN	pleckstrin homology-like domain, family A,	68	PH.				anatomical structure morphogenesis|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|negative regulation of protein kinase B signaling cascade	cytoplasm|intracellular membrane-bounded organelle|plasma membrane	identical protein binding|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|phosphatidylinositol-3,5-bisphosphate binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4,5-bisphosphate binding|phosphatidylinositol-5-phosphate binding				0						ATGTGGCGCCCGGTGCTCTCC	0.687		NaN											1	0	0.00307968	0.00308	0.00528666	7	80									
PPFIA4	8497	broad.mit.edu	37	1	203015064	203015064	+	Silent	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:203015064C>G	uc009xaj.2	+	12	1395	c.1395C>G	c.(1393-1395)CTC>CTG	p.L465L	PPFIA4_uc010pqf.1_Silent_p.L25L			O75335	LIPA4_HUMAN	SubName: Full=Liprin alpha4;	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell communication	cell surface|cytoplasm	protein binding			ovary(4)|skin(1)	5						TCCATGACCTCAATGACAAGC	0.587		NaN											0	0	0	0.004289	0	37	103									
PPP2R5A	5525	broad.mit.edu	37	1	212530372	212530372	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:212530372C>G	uc001hjb.2	+	10	1633	c.1059C>G	c.(1057-1059)TTC>TTG	p.F353L	PPP2R5A_uc010ptd.1_Missense_Mutation_p.F294L	NM_006243	NP_006234	Q15172	2A5A_HUMAN	protein phosphatase 2, regulatory subunit B	353					negative regulation of establishment of protein localization in plasma membrane|negative regulation of lipid kinase activity|positive regulation of protein dephosphorylation|signal transduction	chromosome, centromeric region|cytoplasm|nucleus|protein phosphatase type 2A complex	kinase binding|protein phosphatase type 2A regulator activity			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(81;0.0125)|all cancers(67;0.029)|Epithelial(68;0.154)|GBM - Glioblastoma multiforme(131;0.155)		AGCCACTTTTCAAGCAGATAT	0.308		NaN											0	0	0	0.00333	0	24	46									
TTC13	79573	broad.mit.edu	37	1	231051946	231051946	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:231051946C>T	uc001huf.3	-	18	2117	c.2086G>A	c.(2086-2088)GGA>AGA	p.G696R	TTC13_uc009xfi.2_Missense_Mutation_p.G643R|TTC13_uc009xfj.2_RNA|TTC13_uc001hug.3_Missense_Mutation_p.G642R|TTC13_uc009xfk.1_Missense_Mutation_p.G585R	NM_024525	NP_078801	Q8NBP0	TTC13_HUMAN	tetratricopeptide repeat domain 13 isoform a	696							binding			ovary(1)|skin(1)	2	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)		COAD - Colon adenocarcinoma(196;0.243)		TACTTGTCTCCTGTAATCGTG	0.428		NaN											0	0	0	0.00623	0	39	103									
RYR2	6262	broad.mit.edu	37	1	237838043	237838043	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:237838043C>G	uc001hyl.1	+	60	8847	c.8727C>G	c.(8725-8727)GAC>GAG	p.D2909E	RYR2_uc010pxz.1_5'UTR	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2909	Modulator (Potential).|Cytoplasmic (By similarity).|4 X approximate repeats.|4.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GATTTAAGGACCTGGAACTGG	0.378		NaN											0	0	0	0.000602	0	5	19									
CHRM3	1131	broad.mit.edu	37	1	240072502	240072502	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:240072502G>A	uc001hyp.2	+	5	2530	c.1751G>A	c.(1750-1752)CGC>CAC	p.R584H		NM_000740	NP_000731	P20309	ACM3_HUMAN	cholinergic receptor, muscarinic 3	584	Cytoplasmic (By similarity).				cell proliferation|energy reserve metabolic process|nervous system development|protein modification process|regulation of insulin secretion	basolateral plasma membrane|cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(1)	5	Ovarian(103;0.127)	all_cancers(173;0.00567)|all_neural(198;0.203)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)		Anisotropine Methylbromide(DB00517)|Atropine(DB00572)|Benzquinamide(DB00767)|Cevimeline(DB00185)|Cryptenamine(DB00785)|Cyclizine(DB01176)|Darifenacin(DB00496)|Diphemanil Methylsulfate(DB00729)|Diphenidol(DB01231)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Oxybutynin(DB01062)|Oxyphencyclimine(DB00383)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Solifenacin(DB01591)|Thiethylperazine(DB00372)|Tiotropium(DB01409)|Tolterodine(DB01036)|Tridihexethyl(DB00505)	TTTCACAAGCGCGCACCCGAG	0.522		NaN											0	0	0	0.001368	0	12	47									
PFKFB3	5209	broad.mit.edu	37	10	6258109	6258109	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr10:6258109G>C	uc001ije.2	+	4	705	c.321G>C	c.(319-321)TTG>TTC	p.L107F	PFKFB3_uc001ijd.2_Missense_Mutation_p.L87F|PFKFB3_uc009xii.2_RNA|PFKFB3_uc010qaw.1_Missense_Mutation_p.L121F|PFKFB3_uc001ijf.2_Missense_Mutation_p.L107F	NM_004566	NP_004557	Q16875	F263_HUMAN	6-phosphofructo-2-kinase/fructose-2,	107	6-phosphofructo-2-kinase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity|identical protein binding			ovary(2)|central_nervous_system(1)	3						TAGCTGCCTTGAGAGATGTCA	0.592		NaN											0	0	0	0.005524	0	35	63									
APBB1IP	54518	broad.mit.edu	37	10	26800746	26800746	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr10:26800746G>C	uc001iss.2	+	7	923	c.602G>C	c.(601-603)CGA>CCA	p.R201P	APBB1IP_uc009xks.1_Missense_Mutation_p.R201P	NM_019043	NP_061916	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding,	201	Ras-associating.				blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				lung(4)|skin(2)|central_nervous_system(1)	7						CAGCTGGCCCGAGATGTTCTG	0.473		NaN											0	0	0	0.00278	0	22	64									
WAC	51322	broad.mit.edu	37	10	28906704	28906704	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr10:28906704G>A	uc001iuf.2	+	13	1950	c.1865G>A	c.(1864-1866)CGA>CAA	p.R622Q	WAC_uc001iud.2_Missense_Mutation_p.R577Q|WAC_uc001iue.2_Missense_Mutation_p.R312Q|WAC_uc001iug.2_Missense_Mutation_p.R519Q|WAC_uc001iuh.2_Missense_Mutation_p.R573Q	NM_016628	NP_057712	Q9BTA9	WAC_HUMAN	WW domain-containing adapter with a coiled-coil	622	Potential.				cell cycle checkpoint|histone H2B conserved C-terminal lysine ubiquitination|histone monoubiquitination|positive regulation of transcription, DNA-dependent|response to DNA damage stimulus|transcription, DNA-dependent	nuclear speck	chromatin binding|RNA polymerase II core binding			large_intestine(1)|ovary(1)	2						GCAACTTTGCGAGAGCAAAGG	0.299		NaN											0	0	0	0.00308	0	6	22									
ANK3	288	broad.mit.edu	37	10	61829613	61829613	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr10:61829613C>G	uc001jky.2	-	37	11218	c.11026G>C	c.(11026-11028)GAG>CAG	p.E3676Q	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	3676					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						GTAGGTGTCTCTACATTTCTC	0.552		NaN											0	0	0	0.00245	0	15	52									
ANK3	288	broad.mit.edu	37	10	61959942	61959942	+	Missense_Mutation	SNP	G	G	T	rs138255802		TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr10:61959942G>T	uc001jky.2	-	13	1628	c.1436C>A	c.(1435-1437)GCT>GAT	p.A479D	ANK3_uc010qih.1_Missense_Mutation_p.A462D|ANK3_uc001jkz.3_Missense_Mutation_p.A473D|ANK3_uc001jlb.1_Missense_Mutation_p.A8D|ANK3_uc001jlc.1_Missense_Mutation_p.A140D	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	479	ANK 13.				establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						CACAACTTCAGCTTGGCCGGA	0.463		NaN											1	0	8.00594e-06	0.007413	1.42436e-05	16	40									
SYNPO2L	79933	broad.mit.edu	37	10	75407393	75407393	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr10:75407393C>T	uc001jut.3	-	4	2169	c.2017G>A	c.(2017-2019)GAA>AAA	p.E673K	SYNPO2L_uc001jus.3_Missense_Mutation_p.E449K	NM_001114133	NP_001107605	Q9H987	SYP2L_HUMAN	synaptopodin 2-like isoform a	673	Pro-rich.					cytoplasm|cytoskeleton	actin binding			ovary(1)	1	Prostate(51;0.0112)					GCATCTTCTTCAGGACCAGAT	0.592		NaN											0	0	0	0.00361	0	44	120									
KIAA0913	23053	broad.mit.edu	37	10	75555297	75555297	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr10:75555297G>A	uc009xrl.2	+	15	2926	c.2894G>A	c.(2893-2895)GGC>GAC	p.G965D	KIAA0913_uc001jve.2_Missense_Mutation_p.G970D|KIAA0913_uc001jvf.2_Missense_Mutation_p.G965D|KIAA0913_uc001jvh.2_RNA|KIAA0913_uc001jvi.2_Missense_Mutation_p.G393D|KIAA0913_uc010qkr.1_Missense_Mutation_p.G388D|KIAA0913_uc001jvj.2_Missense_Mutation_p.G388D	NM_015037	NP_055852	A7E2V4	K0913_HUMAN	hypothetical protein LOC23053	965							zinc ion binding			breast(1)	1	Prostate(51;0.0112)					TTTCTCGCAGGCATGAAGACA	0.488		NaN											0	0	0	0.00361	0	42	107									
AP3M1	26985	broad.mit.edu	37	10	75886013	75886013	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr10:75886013C>G	uc001jwf.2	-	7	1334	c.904G>C	c.(904-906)GGG>CGG	p.G302R	AP3M1_uc001jwg.2_Missense_Mutation_p.G302R|AP3M1_uc001jwh.2_Missense_Mutation_p.G302R|AP3M1_uc010qla.1_Missense_Mutation_p.G248R	NM_207012	NP_996895	Q9Y2T2	AP3M1_HUMAN	adaptor-related protein complex 3, mu 1 subunit	302	MHD.				protein targeting to lysosome|vesicle-mediated transport	clathrin adaptor complex|Golgi apparatus|lysosome	protein binding				0	Prostate(51;0.0112)					ATAGTTTTCCCCATATTCTGC	0.403		NaN											0	0	0	0.001882	0	21	73									
KCNMA1	3778	broad.mit.edu	37	10	78649235	78649235	+	Silent	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr10:78649235G>A	uc001jxn.2	-	27	3612	c.3435C>T	c.(3433-3435)CTC>CTT	p.L1145L	KCNMA1_uc001jxj.2_Silent_p.L1091L|KCNMA1_uc001jxk.1_Silent_p.L763L|KCNMA1_uc009xrt.1_Silent_p.L936L|KCNMA1_uc001jxl.1_Silent_p.L770L|KCNMA1_uc001jxo.2_Silent_p.L1128L|KCNMA1_uc001jxm.2_Silent_p.L1087L|KCNMA1_uc001jxq.2_Silent_p.L1117L|uc001jxp.2_Intron	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	1145	Cytoplasmic (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	TGGGGGTGCTGAGGTGAGCAT	0.443		NaN											0	0	0	0.008871	0	18	54									
CYP26C1	340665	broad.mit.edu	37	10	94824180	94824180	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr10:94824180G>T	uc010qns.1	+	4	748	c.748G>T	c.(748-750)GCC>TCC	p.A250S	CYP26C1_uc009xud.2_Intron	NM_183374	NP_899230	Q6V0L0	CP26C_HUMAN	cytochrome P450, family 26, subfamily C,	250					anterior/posterior pattern formation|central nervous system development|negative regulation of retinoic acid receptor signaling pathway|neural crest cell development|organelle fusion|retinoic acid catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|retinoic acid 4-hydroxylase activity|retinoic acid binding			central_nervous_system(1)	1		Colorectal(252;0.122)				CCTGGAGGGGGCCATTTCTGA	0.612		NaN											1	0	5.4927e-09	0.004482	9.99045e-09	8	25									
HIF1AN	55662	broad.mit.edu	37	10	102295784	102295784	+	Silent	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr10:102295784C>T	uc001krj.3	+	1	144	c.69C>T	c.(67-69)CTC>CTT	p.L23L		NM_017902	NP_060372	Q9NWT6	HIF1N_HUMAN	hypoxia-inducible factor 1, alpha subunit	23	Interaction with VHL.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peptide-aspartate beta-dioxygenase activity|protein binding				0		Colorectal(252;0.234)		Epithelial(162;6.75e-10)|all cancers(201;4.88e-08)		CTGGAGCCCTCGGCCCCGCCT	0.537		NaN									OREG0020442	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004672	0	3	4									
SORCS3	22986	broad.mit.edu	37	10	106970924	106970924	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr10:106970924G>T	uc001kyi.1	+	17	2518	c.2291G>T	c.(2290-2292)AGC>ATC	p.S764I	SORCS3_uc010qqz.1_RNA	NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	764	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity	p.S764N(1)		ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CATGGGGAGAGCCAGTGTGTC	0.443		NaN											1	0	2.61681e-11	0.00245	4.83155e-11	12	22									
NRAP	4892	broad.mit.edu	37	10	115349525	115349525	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr10:115349525C>G	uc001laj.2	-	41	5152	c.4988G>C	c.(4987-4989)AGA>ACA	p.R1663T	NRAP_uc009xyb.2_Missense_Mutation_p.R416T|NRAP_uc001lak.2_Missense_Mutation_p.R1628T|NRAP_uc001lal.3_Missense_Mutation_p.R1663T	NM_198060	NP_932326	Q86VF7	NRAP_HUMAN	nebulin-related anchoring protein isoform S	1663	Nebulin 44.					fascia adherens|muscle tendon junction	actin binding|muscle alpha-actinin binding|zinc ion binding			ovary(6)|central_nervous_system(3)|upper_aerodigestive_tract(1)	10		Colorectal(252;0.0233)|Breast(234;0.188)		Epithelial(162;0.00392)|all cancers(201;0.00569)		GCCAACACCTCTGGTCAGGTT	0.542		NaN											0	0	0	0.001786	0	30	58									
DMBT1	1755	broad.mit.edu	37	10	124392811	124392811	+	Missense_Mutation	SNP	G	G	C	rs112645522		TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr10:124392811G>C	uc001lgk.1	+	49	6221	c.6115G>C	c.(6115-6117)GAG>CAG	p.E2039Q	DMBT1_uc001lgl.1_Missense_Mutation_p.E2029Q|DMBT1_uc001lgm.1_Missense_Mutation_p.E1411Q|DMBT1_uc009xzz.1_Missense_Mutation_p.E2038Q|DMBT1_uc010qtx.1_Missense_Mutation_p.E759Q|DMBT1_uc009yab.1_Missense_Mutation_p.E742Q|DMBT1_uc009yac.1_Missense_Mutation_p.E333Q	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	2039	CUB 2.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GTGGGACATTGAGGTGCAAAA	0.512		NaN											0	0	0	0.005443	0	25	55									
DOCK1	1793	broad.mit.edu	37	10	128798508	128798508	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr10:128798508G>A	uc001ljt.2	+	10	986	c.922G>A	c.(922-924)GAG>AAG	p.E308K	DOCK1_uc010qun.1_Missense_Mutation_p.E308K	NM_001380	NP_001371	Q14185	DOCK1_HUMAN	dedicator of cytokinesis 1	308					apoptosis|axon guidance|blood coagulation|integrin-mediated signaling pathway|phagocytosis, engulfment|small GTPase mediated signal transduction	cytosol|membrane	GTP binding|GTPase activator activity|GTPase binding|guanyl-nucleotide exchange factor activity|SH3 domain binding			central_nervous_system(4)|ovary(2)|lung(1)|breast(1)|kidney(1)	9		all_epithelial(44;2.3e-07)|all_lung(145;0.00466)|Lung NSC(174;0.00685)|Colorectal(57;0.0107)|Renal(717;0.0113)|Breast(234;0.0492)|all_neural(114;0.108)|all_hematologic(284;0.14)		BRCA - Breast invasive adenocarcinoma(275;0.0221)|Colorectal(40;0.115)		GGGTCGCATGGAGCTGAGGGA	0.453		NaN											0	0	0	0.000978	0	11	37									
ZNF511	118472	broad.mit.edu	37	10	135125328	135125328	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr10:135125328G>T	uc001lml.1	+	5	688	c.663G>T	c.(661-663)AGG>AGT	p.R221S	TUBGCP2_uc001lmg.1_5'Flank|TUBGCP2_uc010qvc.1_5'Flank|TUBGCP2_uc009ybk.1_5'Flank|TUBGCP2_uc010qvd.1_5'Flank|TUBGCP2_uc001lmh.1_RNA|ZNF511_uc001lmj.1_Missense_Mutation_p.R221S|ZNF511_uc001lmk.1_3'UTR|ZNF511_uc001lmm.1_RNA			Q8NB15	ZN511_HUMAN	SubName: Full=cDNA FLJ78327; SubName: Full=Zinc finger protein 511, isoform CRA_d;	221					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(35;7.01e-07)|all_epithelial(44;1.45e-05)|Lung NSC(174;0.027)|all_lung(145;0.0384)|all_neural(114;0.0726)|Glioma(114;0.172)|Melanoma(40;0.175)		all cancers(32;7.56e-06)|OV - Ovarian serous cystadenocarcinoma(35;8.15e-06)|Epithelial(32;9.99e-06)		CAGGTGAGAGGCGGATCTACA	0.602		NaN											1	0	0.000132079	0.008871	0.000230509	19	72									
HRAS	3265	broad.mit.edu	37	11	534288	534288	+	Missense_Mutation	SNP	C	C	T	rs104894230		TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:534288C>T	uc001lpv.2	-	2	223	c.35G>A	c.(34-36)GGC>GAC	p.G12D	HRAS_uc010qvw.1_Missense_Mutation_p.G12D|HRAS_uc010qvx.1_Missense_Mutation_p.G12D|HRAS_uc010qvy.1_RNA	NM_005343	NP_005334	P01112	RASH_HUMAN	v-Ha-ras Harvey rat sarcoma viral oncogene	12	GTP.		G -> S (in FCSS, OSCC and CMEMS).|G -> E (in FCSS).|G -> C (in FCSS).|G -> A (in FCSS).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.G12V(250)|p.G12S(54)|p.G12D(40)|p.G12C(23)|p.G12R(12)|p.G12A(7)|p.G12_G13insAG(1)		urinary_tract(174)|thyroid(155)|skin(126)|upper_aerodigestive_tract(112)|soft_tissue(37)|prostate(29)|salivary_gland(24)|cervix(23)|stomach(14)|pituitary(10)|lung(9)|haematopoietic_and_lymphoid_tissue(9)|breast(6)|testis(5)|endometrium(4)|bone(3)|large_intestine(2)|oesophagus(2)|penis(2)|kidney(1)|adrenal_gland(1)|thymus(1)	749		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	GCCCACACCGCCGGCGCCCAC	0.647	G12V(T24_URINARY_TRACT)|G12D(HS578T_BREAST)	6	Mis		infrequent sarcomas|rare other types	rhadomyosarcoma|ganglioneuroblastoma|bladder			Costello_syndrome	HNSCC(11;0.0054)			0	0	0	0.006214	0	8	30									
LRDD	55367	broad.mit.edu	37	11	802583	802583	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:802583G>T	uc001lro.1	-	5	1076	c.934C>A	c.(934-936)CCA>ACA	p.P312T	LRDD_uc009yck.1_RNA|LRDD_uc001lrk.1_Missense_Mutation_p.P312T|LRDD_uc001lrl.1_Missense_Mutation_p.P166T|LRDD_uc001lrm.1_5'UTR|LRDD_uc001lrn.1_Missense_Mutation_p.P166T|LRDD_uc001lrp.1_5'UTR	NM_145886	NP_665893	Q9HB75	PIDD_HUMAN	leucine rich repeat and death domain containing	312					apoptosis|signal transduction	cytoplasm|nucleus	death receptor binding				0		all_cancers(49;1.13e-08)|all_epithelial(84;2.95e-05)|Breast(177;0.000286)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.159)|all_lung(207;0.198)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		GGCATTTCTGGAATGAGGGCT	0.587		NaN											1	0	2.56e-06	0.000248	4.56564e-06	4	11									
TRIM21	6737	broad.mit.edu	37	11	4411526	4411526	+	Missense_Mutation	SNP	T	T	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:4411526T>A	uc001lyy.1	-	2	227	c.114A>T	c.(112-114)GAA>GAT	p.E38D		NM_003141	NP_003132	P19474	RO52_HUMAN	tripartite motif protein 21	38	RING-type.				cell cycle|negative regulation of NF-kappaB transcription factor activity|negative regulation of protein deubiquitination|positive regulation of cell cycle|protein autoubiquitination|protein destabilization|protein monoubiquitination|protein polyubiquitination|protein trimerization	cytoplasmic mRNA processing body|nucleus	DNA binding|protein binding|RNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|lung(1)	4		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;2.08e-11)|BRCA - Breast invasive adenocarcinoma(625;0.0851)|LUSC - Lung squamous cell carcinoma(625;0.194)		GAGAGATGCATTCCTGGCAGA	0.587		NaN											0	0	0	0.00623	0	37	66									
OR52L1	338751	broad.mit.edu	37	11	6008147	6008147	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:6008147G>C	uc001mcd.2	-	1	69	c.14C>G	c.(13-15)TCT>TGT	p.S5C		NM_001005173	NP_001005173	Q8NGH7	O52L1_HUMAN	olfactory receptor, family 52, subfamily L,	5	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|pancreas(1)	2		Medulloblastoma(188;0.00776)|all_neural(188;0.0652)|Breast(177;0.114)		Epithelial(150;1.98e-08)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGAGAAAAAAGAAACCAAAGT	0.423		NaN											0	0	0	0.00499	0	16	41									
OR2D3	120775	broad.mit.edu	37	11	6943194	6943194	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:6943194T>C	uc010rav.1	+	1	962	c.962T>C	c.(961-963)GTT>GCT	p.V321A		NM_001004684	NP_001004684	Q8NGH3	OR2D3_HUMAN	olfactory receptor, family 2, subfamily D,	321	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		AGGAAACTAGTTGGGAGAAAG	0.398		NaN											0	0	0	0.001855	0	14	30									
E2F8	79733	broad.mit.edu	37	11	19256582	19256582	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:19256582C>T	uc001mpm.2	-	5	997	c.475G>A	c.(475-477)GAT>AAT	p.D159N	E2F8_uc009yhv.2_RNA|E2F8_uc001mpn.3_Missense_Mutation_p.D159N	NM_024680	NP_078956	A0AVK6	E2F8_HUMAN	E2F family member 8	159	Potential.				cell cycle	transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity			skin(1)	1						TTCACGATATCGTAAATGCGT	0.423		NaN											0	0	0	0.008291	0	9	21									
COMMD9	29099	broad.mit.edu	37	11	36297787	36297787	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:36297787G>C	uc001mwn.3	-	5	393	c.356C>G	c.(355-357)TCT>TGT	p.S119C	COMMD9_uc009ykj.2_Missense_Mutation_p.S77C|COMMD9_uc009yki.1_5'Flank	NM_014186	NP_054905	Q9P000	COMD9_HUMAN	COMM domain containing 9 isoform 1	119										ovary(1)	1	all_lung(20;0.211)	all_hematologic(20;0.107)				GCGTGGCAGAGAGACTGTGGA	0.557		NaN											0	0	0	0.001855	0	12	32									
TNKS1BP1	85456	broad.mit.edu	37	11	57075938	57075938	+	Nonsense_Mutation	SNP	G	G	T	rs141792675	byFrequency	TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:57075938G>T	uc001njr.2	-	5	4559	c.4247C>A	c.(4246-4248)TCG>TAG	p.S1416*	TNKS1BP1_uc001njs.2_Nonsense_Mutation_p.S1416*|TNKS1BP1_uc009ymd.1_Nonsense_Mutation_p.S867*	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	1416	Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				CAAGGAAGACGAGGAGTAATC	0.607		NaN											1	0	3.1745e-13	0.008361	5.90585e-13	32	219									
OR5A1	219982	broad.mit.edu	37	11	59211229	59211229	+	Silent	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:59211229C>T	uc001nnx.1	+	1	588	c.588C>T	c.(586-588)TTC>TTT	p.F196F		NM_001004728	NP_001004728	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A,	196	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2						CTGACACCTTCCTCAGTCAAG	0.512		NaN											0	0	0	0.00361	0	66	142									
OR5A1	219982	broad.mit.edu	37	11	59211279	59211279	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:59211279C>A	uc001nnx.1	+	1	638	c.638C>A	c.(637-639)TCG>TAG	p.S213*		NM_001004728	NP_001004728	Q8NGJ0	OR5A1_HUMAN	olfactory receptor, family 5, subfamily A,	213	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|central_nervous_system(1)	2						GGAGGAACATCGTTCCTCCAA	0.542		NaN											1	0	4.00472e-15	0.00361	7.50757e-15	47	98									
GANAB	23193	broad.mit.edu	37	11	62396347	62396347	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:62396347G>A	uc001nub.2	-	17	2107	c.2074C>T	c.(2074-2076)CAG>TAG	p.Q692*	GANAB_uc001ntz.2_5'Flank|GANAB_uc001nua.2_Nonsense_Mutation_p.Q714*|GANAB_uc001nuc.2_Nonsense_Mutation_p.Q595*|GANAB_uc010rma.1_Nonsense_Mutation_p.Q600*|GANAB_uc010rmb.1_Nonsense_Mutation_p.Q578*	NM_198334	NP_938148	Q14697	GANAB_HUMAN	neutral alpha-glucosidase AB isoform 2	692					post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|Golgi apparatus|melanosome	carbohydrate binding|glucan 1,3-alpha-glucosidase activity|protein binding			ovary(3)|central_nervous_system(1)|skin(1)	5						TCATTGTGCTGAGATGGTAAC	0.547		NaN											0	0	0	0.006999	0	40	101									
NPAS4	266743	broad.mit.edu	37	11	66192075	66192075	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:66192075G>A	uc001ohx.1	+	7	1890	c.1714G>A	c.(1714-1716)GAG>AAG	p.E572K	NPAS4_uc010rpc.1_Missense_Mutation_p.E362K	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	572					transcription, DNA-dependent		DNA binding|signal transducer activity				0						TTTTCTCTATGAGAAGTTGCC	0.602		NaN											0	0	0	0.005524	0	35	115									
RBM14	10432	broad.mit.edu	37	11	66384516	66384516	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:66384516G>C	uc001oit.2	+	1	464	c.325G>C	c.(325-327)GAC>CAC	p.D109H	RBM14_uc009yrh.2_Missense_Mutation_p.D109H|RBM14_uc009yri.2_Missense_Mutation_p.D109H|RBM4_uc009yrj.2_5'UTR|RBM4_uc009yrk.2_Missense_Mutation_p.D109H	NM_006328	NP_006319	Q96PK6	RBM14_HUMAN	RNA binding motif protein 14	109	RRM 2.				DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|histone deacetylation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus	mediator complex|ribonucleoprotein complex|transcription factor complex	ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|protein binding, bridging|RNA binding|RNA polymerase II transcription cofactor activity			ovary(2)|central_nervous_system(1)	3						CATCGAGTGTGACGTGGTGAA	0.652		NaN											0	0	0	0.006122	0	16	43									
TBC1D10C	374403	broad.mit.edu	37	11	67173129	67173129	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:67173129C>G	uc001ola.2	+	5	453	c.424C>G	c.(424-426)CAA>GAA	p.Q142E	PPP1CA_uc001okx.1_Intron|TBC1D10C_uc001okz.2_Missense_Mutation_p.Q142E|TBC1D10C_uc001olb.2_RNA	NM_198517	NP_940919	Q8IV04	TB10C_HUMAN	TBC1 domain family, member 10C	142	Rab-GAP TBC.					intracellular	Rab GTPase activator activity				0			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			CCTGCACCGTCAATTCCCTCT	0.647		NaN											0	0	0	0.00499	0	16	41									
GSTP1	2950	broad.mit.edu	37	11	67353675	67353675	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:67353675G>T	uc001omf.2	+	6	686	c.437G>T	c.(436-438)GGA>GTA	p.G146V	GSTP1_uc001omg.1_Missense_Mutation_p.G127V	NM_000852	NP_000843	P09211	GSTP1_HUMAN	glutathione transferase	146	GST C-terminal.				anti-apoptosis|cellular response to lipopolysaccharide|central nervous system development|common myeloid progenitor cell proliferation|glutathione metabolic process|negative regulation of acute inflammatory response|negative regulation of ERK1 and ERK2 cascade|negative regulation of fibroblast proliferation|negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 beta production|negative regulation of JUN kinase activity|negative regulation of leukocyte proliferation|negative regulation of monocyte chemotactic protein-1 production|negative regulation of necrotic cell death|negative regulation of nitric-oxide synthase 2 biosynthetic process|negative regulation of stress-activated MAPK cascade|negative regulation of tumor necrosis factor production|nitric oxide storage|positive regulation of superoxide anion generation|response to reactive oxygen species|xenobiotic metabolic process	cytosol|protein complex	dinitrosyl-iron complex binding|glutathione transferase activity|JUN kinase binding|kinase regulator activity|nitric oxide binding|S-nitrosoglutathione binding			ovary(1)	1					Ethacrynic acid(DB00903)|Glutathione(DB00143)	TTCATTGTGGGAGACCAGGTG	0.567		NaN											1	0	2.17888e-05	0.006214	3.83922e-05	9	16									
SERPINH1	871	broad.mit.edu	37	11	75277666	75277666	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:75277666C>T	uc001owr.2	+	2	501	c.272C>T	c.(271-273)TCG>TTG	p.S91L	SERPINH1_uc009yuf.2_Missense_Mutation_p.S91L|SERPINH1_uc009yug.2_Missense_Mutation_p.S91L|SERPINH1_uc001ows.2_Missense_Mutation_p.S91L|SERPINH1_uc001owt.2_5'Flank	NM_001235	NP_001226	P50454	SERPH_HUMAN	serine (or cysteine) proteinase inhibitor, clade	91					regulation of proteolysis|response to unfolded protein	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	collagen binding|serine-type endopeptidase inhibitor activity			ovary(2)	2	Ovarian(111;0.11)					ACCACGGCGTCGCAGGCCAAG	0.701		NaN											0	0	0	0.001168	0	6	19									
DLG2	1740	broad.mit.edu	37	11	83641425	83641425	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:83641425G>C	uc001paj.2	-	10	1430	c.1127C>G	c.(1126-1128)TCA>TGA	p.S376*	DLG2_uc001pai.2_Intron|DLG2_uc010rsy.1_Nonsense_Mutation_p.S343*|DLG2_uc010rsz.1_Nonsense_Mutation_p.S376*|DLG2_uc010rta.1_Nonsense_Mutation_p.S376*|DLG2_uc001pak.2_Nonsense_Mutation_p.S481*|DLG2_uc010rtb.1_Nonsense_Mutation_p.S343*|DLG2_uc001pal.1_Nonsense_Mutation_p.S376*|DLG2_uc001pam.1_Nonsense_Mutation_p.S415*	NM_001364	NP_001355	Q15700	DLG2_HUMAN	chapsyn-110 isoform 2	376						cell junction|postsynaptic density|postsynaptic membrane	guanylate kinase activity|protein binding|protein binding			ovary(3)|pancreas(2)|skin(1)	6		all_cancers(6;0.00791)|Acute lymphoblastic leukemia(157;4.44e-05)|all_hematologic(158;0.0036)				ATAGGGAGCTGAGAGGAGGAA	0.512		NaN											0	0	0	0.001882	0	19	51									
TYR	7299	broad.mit.edu	37	11	89028453	89028453	+	Silent	SNP	G	G	A	rs138750983	byFrequency	TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:89028453G>A	uc001pcs.2	+	5	1591	c.1509G>A	c.(1507-1509)AAG>AAA	p.K503K		NM_000372	NP_000363	P14679	TYRO_HUMAN	tyrosinase precursor	503	Cytoplasmic (Potential).				eye pigment biosynthetic process|melanin biosynthetic process from tyrosine|visual perception	Golgi-associated vesicle|integral to membrane|lysosome|melanosome membrane|perinuclear region of cytoplasm	copper ion binding|monophenol monooxygenase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(157;2.33e-05)|all_hematologic(158;0.0033)			Azelaic Acid(DB00548)|Mimosine(DB01055)|NADH(DB00157)	GTCGTCACAAGAGAAAGCAGC	0.532		NaN							Oculocutaneous_Albinism				0	0	0	0.004482	0	8	26									
DYNC2H1	79659	broad.mit.edu	37	11	103041631	103041631	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:103041631C>T	uc001pho.2	+	34	5312	c.5168C>T	c.(5167-5169)TCA>TTA	p.S1723L	DYNC2H1_uc001phn.1_Missense_Mutation_p.S1723L|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	1723	AAA 1 (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		GATGTGAAGTCAATGGGACGA	0.299		NaN											0	0	0	0.001984	0	7	20									
DDI1	414301	broad.mit.edu	37	11	103908506	103908506	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:103908506C>G	uc001phr.2	+	1	1199	c.956C>G	c.(955-957)TCC>TGC	p.S319C	PDGFD_uc001php.2_Intron|PDGFD_uc001phq.2_Intron	NM_001001711	NP_001001711	Q8WTU0	DDI1_HUMAN	DDI1, DNA-damage inducible 1, homolog 1	319					proteolysis		aspartic-type endopeptidase activity			large_intestine(3)|upper_aerodigestive_tract(1)|pancreas(1)	5		Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.00648)|Melanoma(852;0.055)|all_neural(303;0.164)		BRCA - Breast invasive adenocarcinoma(274;0.00128)|Epithelial(105;0.0631)|all cancers(92;0.169)		TGCTCTTTCTCCATACTTGAG	0.453		NaN											0	0	0	0.002836	0	33	86									
CADM1	23705	broad.mit.edu	37	11	115085457	115085457	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:115085457G>C	uc001ppi.3	-	7	994	c.865C>G	c.(865-867)CAA>GAA	p.Q289E	CADM1_uc001ppf.3_Missense_Mutation_p.Q289E|CADM1_uc001ppk.3_Missense_Mutation_p.Q289E|CADM1_uc001ppj.3_Missense_Mutation_p.Q289E|CADM1_uc001ppl.2_Missense_Mutation_p.Q289E|CADM1_uc001pph.3_Missense_Mutation_p.Q41E	NM_014333	NP_055148	Q9BY67	CADM1_HUMAN	immunoglobulin superfamily, member 4D isoform 1	289	Ig-like C2-type 2.|Extracellular (Potential).				adherens junction organization|apoptosis|cell differentiation|cell junction assembly|cell recognition|detection of stimulus|heterophilic cell-cell adhesion|homophilic cell adhesion|multicellular organismal development|positive regulation of cytokine secretion|spermatogenesis|susceptibility to natural killer cell mediated cytotoxicity	basolateral plasma membrane|cell-cell junction|integral to membrane	PDZ domain binding|protein C-terminus binding|protein homodimerization activity|receptor binding			ovary(2)	2	all_hematologic(175;0.0628)	all_cancers(61;2.98e-14)|all_epithelial(67;2.64e-08)|all_hematologic(158;0.000154)|Melanoma(852;0.000952)|Acute lymphoblastic leukemia(157;0.00101)|Breast(348;0.0102)|Medulloblastoma(222;0.0429)|Prostate(24;0.145)|all_neural(223;0.237)		BRCA - Breast invasive adenocarcinoma(274;5.01e-06)|Epithelial(105;0.000305)|all cancers(92;0.00303)		ACGGCGTGTTGAGGCATTTCA	0.473		NaN											0	0	0	0.002836	0	28	71									
CD3E	916	broad.mit.edu	37	11	118185207	118185207	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:118185207G>C	uc001psq.3	+	8	821	c.565G>C	c.(565-567)GAG>CAG	p.E189Q		NM_000733	NP_000724	P07766	CD3E_HUMAN	CD3E antigen, epsilon polypeptide precursor	189	Cytoplasmic (Potential).|ITAM.				G-protein coupled receptor protein signaling pathway|signal complex assembly|T cell costimulation|T cell receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway	external side of plasma membrane|integral to plasma membrane	protein heterodimerization activity|protein kinase binding|receptor signaling complex scaffold activity|receptor signaling protein activity|SH3 domain binding|T cell receptor binding|transmembrane receptor activity			ovary(2)	2	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.09e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0251)	Muromonab(DB00075)	CCCAGACTATGAGGTAACGTG	0.557		NaN											0	0	0	0.004482	0	9	14									
ABCG4	64137	broad.mit.edu	37	11	119029009	119029009	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:119029009C>G	uc001pvs.2	+	10	1470	c.1134C>G	c.(1132-1134)TTC>TTG	p.F378L	ABCG4_uc009zar.2_Missense_Mutation_p.F378L	NM_022169	NP_071452	Q9H172	ABCG4_HUMAN	ATP-binding cassette, subfamily G, member 4	378	Cytoplasmic (Potential).				cholesterol efflux	integral to membrane	ATP binding|ATPase activity|protein heterodimerization activity|protein homodimerization activity			ovary(2)	2	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.7e-05)		GCATCCTCTTCAAGAGGACCT	0.577		NaN											0	0	0	0.00361	0	94	183									
TECTA	7007	broad.mit.edu	37	11	120980049	120980049	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:120980049G>C	uc010rzo.1	+	3	328	c.328G>C	c.(328-330)GAG>CAG	p.E110Q		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	110	NIDO.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		AATTCGAGGCGAGATCTATTA	0.512		NaN											0	0	0	0.001786	0	28	58									
OR8B4	283162	broad.mit.edu	37	11	124294715	124294715	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:124294715G>A	uc010sak.1	-	1	53	c.53C>T	c.(52-54)TCA>TTA	p.S18L		NM_001005196	NP_001005196	Q96RC9	OR8B4_HUMAN	olfactory receptor, family 8, subfamily B,	18	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		TGGCTGTTCTGATAATCCCAC	0.478		NaN											0	0	0	0.00499	0	17	36									
SIAE	54414	broad.mit.edu	37	11	124524628	124524628	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:124524628G>A	uc001qan.2	-	4	580	c.467C>T	c.(466-468)TCT>TTT	p.S156F		NM_170601	NP_733746	Q9HAT2	SIAE_HUMAN	sialate O-acetylesterase precursor	156						extracellular region|lysosome	carboxylesterase activity|sialate O-acetylesterase activity				0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0243)		GGGAGAGACAGAGAGGATGCG	0.488		NaN											0	0	0	0.00361	0	50	114									
ROBO4	54538	broad.mit.edu	37	11	124766183	124766183	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:124766183G>A	uc001qbg.2	-	4	730	c.590C>T	c.(589-591)GCA>GTA	p.A197V	ROBO4_uc010sas.1_Missense_Mutation_p.A52V|ROBO4_uc001qbh.2_Missense_Mutation_p.A87V|ROBO4_uc001qbi.2_5'Flank|ROBO4_uc010sat.1_5'Flank	NM_019055	NP_061928	Q8WZ75	ROBO4_HUMAN	roundabout homolog 4, magic roundabout	197	Ig-like C2-type 2.				angiogenesis|cell differentiation	integral to membrane	receptor activity			ovary(1)|skin(1)	2	all_hematologic(175;0.215)	Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|Breast(109;0.171)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.5e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0301)		ACTCTTCTCTGCTCTTGCCAT	0.617		NaN											0	0	0	0.002299	0	21	52									
NTM	50863	broad.mit.edu	37	11	132082042	132082042	+	Splice_Site	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr11:132082042G>A	uc001qgp.2	+	3	1190	c.526_splice	c.e3+1	p.A176_splice	NTM_uc001qgm.2_Splice_Site_p.A176_splice|NTM_uc010sch.1_Splice_Site_p.A167_splice|NTM_uc010sci.1_Splice_Site_p.A176_splice|NTM_uc010scj.1_Splice_Site_p.A135_splice|NTM_uc001qgo.2_Splice_Site_p.A176_splice|NTM_uc001qgq.2_Splice_Site_p.A176_splice|NTM_uc001qgr.2_Splice_Site	NM_016522	NP_057606	Q9P121	NTRI_HUMAN	neurotrimin isoform 1						cell adhesion|neuron recognition	anchored to membrane|plasma membrane				ovary(4)|central_nervous_system(1)|skin(1)	6						TCTCCCAAAGGTAAGAGAACA	0.453		NaN											0	0	0	0.005524	0	35	89									
KCNA1	3736	broad.mit.edu	37	12	5021124	5021124	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:5021124G>A	uc001qnh.2	+	2	1685	c.580G>A	c.(580-582)GAT>AAT	p.D194N		NM_000217	NP_000208	Q09470	KCNA1_HUMAN	potassium voltage-gated channel subfamily A	194					synaptic transmission	juxtaparanode region of axon|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium ion transmembrane transporter activity			ovary(1)|skin(1)	2					Desflurane(DB01189)|Enflurane(DB00228)|Isoflurane(DB00753)|Methoxyflurane(DB01028)|Sevoflurane(DB01236)	CGAGCTGAAGGATGACAAGGA	0.572		NaN											0	0	0	0.00499	0	18	30									
CHD4	1108	broad.mit.edu	37	12	6690875	6690875	+	Missense_Mutation	SNP	G	G	C	rs143753094		TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:6690875G>C	uc001qpo.2	-	31	4785	c.4621C>G	c.(4621-4623)CCT>GCT	p.P1541A	CHD4_uc001qpn.2_Missense_Mutation_p.P1534A|CHD4_uc001qpp.2_Missense_Mutation_p.P1566A|uc001qpq.1_Intron|SCARNA11_uc001qpr.1_5'Flank	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1541					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						GAGGGTGTAGGAGTTTTTGGG	0.547		NaN											0	0	0	0.008871	0	19	66									
CHD4	1108	broad.mit.edu	37	12	6692427	6692427	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:6692427G>C	uc001qpo.2	-	26	4161	c.3997C>G	c.(3997-3999)CTG>GTG	p.L1333V	CHD4_uc001qpn.2_Missense_Mutation_p.L1326V|CHD4_uc001qpp.2_Missense_Mutation_p.L1330V|uc001qpq.1_3'UTR|SCARNA11_uc001qpr.1_5'Flank	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1333					chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						CCTTTGCCCAGATTTCGGGCT	0.537		NaN											0	0	0	0.00361	0	89	171									
KIAA1467	57613	broad.mit.edu	37	12	13219676	13219676	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:13219676G>A	uc001rbi.2	+	6	978	c.955G>A	c.(955-957)GTT>ATT	p.V319I	KIAA1467_uc009zhx.1_RNA	NM_020853	NP_065904	A2RU67	K1467_HUMAN	hypothetical protein LOC57613	319						integral to membrane				central_nervous_system(2)|skin(1)	3		Prostate(47;0.184)		BRCA - Breast invasive adenocarcinoma(232;0.157)		TGGTCCTCAGGTTTACATCAC	0.502		NaN											0	0	0	0.001368	0	12	42									
GUCY2C	2984	broad.mit.edu	37	12	14840914	14840914	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:14840914C>T	uc001rcd.2	-	2	438	c.301G>A	c.(301-303)GAA>AAA	p.E101K	GUCY2C_uc009zhz.2_Missense_Mutation_p.E101K	NM_004963	NP_004954	P25092	GUC2C_HUMAN	guanylate cyclase 2C precursor	101	Extracellular (Potential).				intracellular signal transduction|receptor guanylyl cyclase signaling pathway	integral to membrane	ATP binding|GTP binding|guanylate cyclase activity|protein binding|protein kinase activity|receptor activity			ovary(4)|skin(2)	6						TCGAGGCCTTCACAGGTGCTA	0.488		NaN											0	0	0	0.00632	0	25	76									
C12orf72	254013	broad.mit.edu	37	12	31819050	31819050	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:31819050G>A	uc009zjr.2	+	3	553	c.344G>A	c.(343-345)AGA>AAA	p.R115K	C12orf72_uc001rkl.2_Missense_Mutation_p.R115K|C12orf72_uc001rkm.2_Missense_Mutation_p.R115K	NM_001135864	NP_001129336	Q8IXQ9	MET20_HUMAN	hypothetical protein LOC254013	115						cytoplasm	protein methyltransferase activity				0						GATGTTGTCAGAGGAAAATCT	0.353		NaN											0	0	0	0.001855	0	14	31									
LRRK2	120892	broad.mit.edu	37	12	40716180	40716180	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:40716180C>T	uc001rmg.3	+	37	5498	c.5377C>T	c.(5377-5379)CCT>TCT	p.P1793S	LRRK2_uc009zjw.2_Missense_Mutation_p.P631S|LRRK2_uc001rmi.2_Missense_Mutation_p.P626S	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	1793					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				AGAATGGTTTCCTGGGTTGCT	0.383		NaN											0	0	0	0.002222	0	40	109									
ADAMTS20	80070	broad.mit.edu	37	12	43925874	43925874	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:43925874G>A	uc010skx.1	-	3	578	c.578C>T	c.(577-579)TCT>TTT	p.S193F		NM_025003	NP_079279	P59510	ATS20_HUMAN	a disintegrin-like and metalloprotease with	193						proteinaceous extracellular matrix	zinc ion binding			central_nervous_system(5)|ovary(4)|lung(3)|large_intestine(2)|skin(2)|urinary_tract(1)|kidney(1)|pancreas(1)	19	all_cancers(12;2.6e-05)|Lung SC(27;0.184)	Lung NSC(34;0.0569)|all_lung(34;0.129)		GBM - Glioblastoma multiforme(48;0.0473)		CTGCAGAAAAGAGTTATTTAA	0.328		NaN											0	0	0	0.001855	0	14	23									
KRT8	3856	broad.mit.edu	37	12	53298670	53298670	+	Silent	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:53298670G>A	uc001sbd.2	-	1	199	c.96C>T	c.(94-96)CGC>CGT	p.R32R	KRT8_uc009zmj.2_Silent_p.R32R|KRT8_uc009zmk.1_Silent_p.R60R|KRT8_uc009zml.1_Silent_p.R32R|KRT8_uc009zmm.1_Silent_p.R32R	NM_002273	NP_002264	P05787	K2C8_HUMAN	keratin 8	32	Head.|Ser-rich.				cytoskeleton organization|interspecies interaction between organisms	cytoplasm|keratin filament|nuclear matrix|nucleoplasm	protein binding|structural molecule activity			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(357;0.108)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AGGAGCTGATGCGGGAACCGG	0.667		NaN											0	0	0	0.008291	0	11	13									
TMEM194A	23306	broad.mit.edu	37	12	57453736	57453736	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:57453736C>T	uc001smy.2	-	9	1307	c.1261G>A	c.(1261-1263)GAG>AAG	p.E421K	TMEM194A_uc001smx.2_Missense_Mutation_p.E348K|TMEM194A_uc010sra.1_Missense_Mutation_p.E162K	NM_001130963	NP_001124435	O14524	T194A_HUMAN	transmembrane protein 194A isoform a	421						integral to membrane					0						GATGCTTCCTCATAGATTTCA	0.463		NaN											0	0	0	0.001368	0	13	33									
TMEM194A	23306	broad.mit.edu	37	12	57453784	57453784	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:57453784C>T	uc001smy.2	-	9	1259	c.1213G>A	c.(1213-1215)GAG>AAG	p.E405K	TMEM194A_uc001smx.2_Missense_Mutation_p.E332K|TMEM194A_uc010sra.1_Missense_Mutation_p.E146K	NM_001130963	NP_001124435	O14524	T194A_HUMAN	transmembrane protein 194A isoform a	405						integral to membrane					0						TACTCCTGCTCATGGACAGAA	0.448		NaN											0	0	0	0.003163	0	15	46									
GLI1	2735	broad.mit.edu	37	12	57865455	57865455	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:57865455G>C	uc001snx.2	+	12	3010	c.2932G>C	c.(2932-2934)GCA>CCA	p.A978P	GLI1_uc009zpq.2_Missense_Mutation_p.A850P	NM_005269	NP_005260	P08151	GLI1_HUMAN	GLI family zinc finger 1 isoform 1	978					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			skin(4)|ovary(4)|breast(3)|central_nervous_system(1)|urinary_tract(1)|kidney(1)|pancreas(1)	15			GBM - Glioblastoma multiforme(3;3.99e-32)			TGTAGTGGGGGCAAATAGGGC	0.537		NaN											0	0	0	0.003271	0	34	62									
ARHGAP9	64333	broad.mit.edu	37	12	57871349	57871349	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:57871349C>G	uc001sod.2	-	7	1055	c.862G>C	c.(862-864)GAT>CAT	p.D288H	ARHGAP9_uc001sny.2_5'Flank|ARHGAP9_uc001snz.2_Missense_Mutation_p.D33H|ARHGAP9_uc001soa.2_5'UTR|ARHGAP9_uc001sob.2_Missense_Mutation_p.D217H|ARHGAP9_uc001soc.2_Missense_Mutation_p.D217H|ARHGAP9_uc001soe.1_Missense_Mutation_p.D296H|ARHGAP9_uc010sro.1_Missense_Mutation_p.D217H	NM_032496	NP_115885	Q9BRR9	RHG09_HUMAN	Rho GTPase activating protein 9 isoform 1	217	WW.				regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|protein binding			lung(1)	1			GBM - Glioblastoma multiforme(3;3.37e-34)			TCCCAGGCATCCAGCCTCTGC	0.642		NaN											0	0	0	0.001882	0	20	52									
LRRIQ1	84125	broad.mit.edu	37	12	85438530	85438530	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:85438530G>A	uc001tac.2	+	4	390	c.279G>A	c.(277-279)ATG>ATA	p.M93I	LRRIQ1_uc001tab.1_Missense_Mutation_p.M93I|LRRIQ1_uc001taa.1_Missense_Mutation_p.M93I|LRRIQ1_uc001tad.2_Missense_Mutation_p.M1I	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	93										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		ATAATCATATGCATTTAAGAA	0.259		NaN											0	0	0	0.008291	0	9	30									
UBE3B	89910	broad.mit.edu	37	12	109927779	109927779	+	Silent	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:109927779C>G	uc001top.2	+	8	1203	c.600C>G	c.(598-600)CTC>CTG	p.L200L	UBE3B_uc001toq.2_Silent_p.L200L|UBE3B_uc001tol.1_Silent_p.L200L|UBE3B_uc001tom.2_Silent_p.L200L|UBE3B_uc001ton.2_Silent_p.L200L|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Silent_p.L200L|UBE3B_uc001tor.2_Silent_p.L200L	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	200					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						TGGGACATCTCAACCAGCATG	0.428		NaN											0	0	0	0.001786	0	27	79									
UBE3B	89910	broad.mit.edu	37	12	109928922	109928922	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:109928922C>G	uc001top.2	+	9	1306	c.703C>G	c.(703-705)CTA>GTA	p.L235V	UBE3B_uc001toq.2_Missense_Mutation_p.L235V|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Missense_Mutation_p.L235V	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	235					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						AGCTTTTTCTCTAGCGTTACG	0.428		NaN											0	0	0	0.004656	0	19	35									
UBE3B	89910	broad.mit.edu	37	12	109937445	109937445	+	Silent	SNP	C	C	G	rs150323950	by1000genomes	TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:109937445C>G	uc001top.2	+	12	1551	c.948C>G	c.(946-948)CTC>CTG	p.L316L	UBE3B_uc001toq.2_Silent_p.L316L|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Silent_p.L316L	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	316					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						TAGGCAACCTCCTACACTTGG	0.582		NaN											0	0	0	0.001168	0	6	12									
UBE3B	89910	broad.mit.edu	37	12	109939251	109939251	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:109939251C>A	uc001top.2	+	13	1797	c.1194C>A	c.(1192-1194)TTC>TTA	p.F398L	UBE3B_uc001toq.2_Missense_Mutation_p.F398L|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Missense_Mutation_p.F398L	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	398					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						GGATCTTCTTCTGTGACATCC	0.562		NaN											1	0	2.91434e-09	0.004878	5.31395e-09	37	88									
UBE3B	89910	broad.mit.edu	37	12	109961811	109961811	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:109961811C>G	uc001top.2	+	22	2996	c.2393C>G	c.(2392-2394)TCC>TGC	p.S798C	UBE3B_uc001toq.2_Missense_Mutation_p.S798C|UBE3B_uc001tos.2_Missense_Mutation_p.S225C|UBE3B_uc001too.1_RNA|UBE3B_uc009zvj.1_Missense_Mutation_p.S798C	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	798	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						CCATTTGCATCCTTCTTCCTG	0.532		NaN											0	0	0	0.008361	0	28	101									
DYNLL1	8655	broad.mit.edu	37	12	120935923	120935923	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:120935923G>C	uc001tyj.2	+	3	434	c.180G>C	c.(178-180)AGG>AGC	p.R60S	uc001tyk.1_5'Flank|DYNLL1_uc001tyl.2_Missense_Mutation_p.R60S|DYNLL1_uc001tym.2_Missense_Mutation_p.R60S	NM_001037494	NP_001032583	P63167	DYL1_HUMAN	dynein light chain 1	60					actin cytoskeleton organization|activation of pro-apoptotic gene products|anatomical structure morphogenesis|female gamete generation|G2/M transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|microtubule-based process|negative regulation of phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transport	centrosome|cytoplasmic dynein complex|cytosol|microtubule|mitochondrion|nucleus|plasma membrane	motor activity|protein binding				0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					TCGTGGGGAGGAACTTCGGTA	0.418		NaN											0	0	0	0.006214	0	8	29									
ZNF664	144348	broad.mit.edu	37	12	124496822	124496822	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:124496822C>T	uc001ufz.2	+	6	1961	c.131C>T	c.(130-132)TCA>TTA	p.S44L	ZNF664_uc001uga.2_Missense_Mutation_p.S44L|ZNF664_uc001ugb.2_Missense_Mutation_p.S44L	NM_152437	NP_689650	Q8N3J9	ZN664_HUMAN	zinc finger protein 664	44	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_neural(191;0.101)|Medulloblastoma(191;0.163)			Epithelial(86;0.000239)|OV - Ovarian serous cystadenocarcinoma(86;0.000247)|all cancers(50;0.00155)|BRCA - Breast invasive adenocarcinoma(302;0.249)		TTTCATATATCAGAACTTCAT	0.353		NaN											0	0	0	0.00278	0	22	86									
TMEM132B	114795	broad.mit.edu	37	12	125834167	125834167	+	Silent	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr12:125834167C>T	uc001uhe.1	+	2	230	c.222C>T	c.(220-222)TTC>TTT	p.F74F		NM_052907	NP_443139	Q14DG7	T132B_HUMAN	transmembrane protein 132B	74	Extracellular (Potential).					integral to membrane				skin(11)|ovary(5)|large_intestine(1)|pancreas(1)|breast(1)	19	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000423)|Epithelial(86;0.00394)|all cancers(50;0.0362)		AGCCATTCTTCATCTACCGAG	0.512		NaN											0	0	0	0.00361	0	48	97									
IFT88	8100	broad.mit.edu	37	13	21175890	21175890	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr13:21175890C>T	uc001unh.2	+	14	1282	c.886C>T	c.(886-888)CAG>TAG	p.Q296*	IFT88_uc001uni.2_Nonsense_Mutation_p.Q287*|IFT88_uc001unj.2_Nonsense_Mutation_p.Q286*|IFT88_uc010tcq.1_Nonsense_Mutation_p.Q267*|IFT88_uc001unk.2_Intron	NM_175605	NP_783195	Q13099	IFT88_HUMAN	intraflagellar transport 88 homolog isoform 1	296	TPR 3.				cilium morphogenesis	centriole|intraflagellar transport particle B|microtubule basal body|microtubule-based flagellum	protein binding			ovary(1)	1		all_cancers(29;5.79e-25)|all_epithelial(30;2.57e-20)|all_lung(29;3.13e-16)|Lung SC(185;0.0262)|Ovarian(182;0.0825)|Hepatocellular(188;0.244)		all cancers(112;0.000667)|Epithelial(112;0.00119)|OV - Ovarian serous cystadenocarcinoma(117;0.0141)|Lung(94;0.0183)|LUSC - Lung squamous cell carcinoma(192;0.0528)		TCAGGCTGGTCAGTATTCAGA	0.338		NaN											0	0	0	0.001855	0	13	52									
MTUS2	23281	broad.mit.edu	37	13	29599309	29599309	+	Silent	SNP	T	T	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr13:29599309T>C	uc001usl.3	+	1	562	c.504T>C	c.(502-504)GTT>GTC	p.V168V		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	158						cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						CCCGGCATGTTCCCAAGGATA	0.507		NaN											0	0	0	0.005443	0	26	59									
NHLRC3	387921	broad.mit.edu	37	13	39621205	39621205	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr13:39621205G>C	uc001uxc.2	+	6	1029	c.707G>C	c.(706-708)AGA>ACA	p.R236T	NHLRC3_uc001uxd.2_Missense_Mutation_p.R169T|NHLRC3_uc001uxe.2_Missense_Mutation_p.R39T	NM_001012754	NP_001012772	Q5JS37	NHLC3_HUMAN	NHL repeat containing 3 isoform a	236	NHL 3.					extracellular region				skin(1)	1		Lung NSC(96;6.01e-07)|Breast(139;0.00394)|Prostate(109;0.00676)|Lung SC(185;0.0548)|Hepatocellular(188;0.114)		all cancers(112;2.37e-08)|Epithelial(112;3.14e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.00101)|BRCA - Breast invasive adenocarcinoma(63;0.00335)|GBM - Glioblastoma multiforme(144;0.0128)		GGAAATAAAAGAATCCAAGTA	0.358		NaN											0	0	0	0.001523	0	20	40									
PCDH8	5100	broad.mit.edu	37	13	53422431	53422431	+	Silent	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr13:53422431C>T	uc001vhi.2	-	1	344	c.141G>A	c.(139-141)GGG>GGA	p.G47G	PCDH8_uc001vhj.2_Silent_p.G47G	NM_002590	NP_002581	O95206	PCDH8_HUMAN	protocadherin 8 isoform 1 precursor	47	Extracellular (Potential).|Cadherin 1.				cell-cell signaling|homophilic cell adhesion	cell junction|dendrite|integral to plasma membrane|postsynaptic membrane|presynaptic membrane	calcium ion binding			breast(1)	1		Lung NSC(96;0.0019)|Breast(56;0.00235)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.19e-08)		CGGCCAGGGTCCCGATGACCG	0.602		NaN											0	0	0	0.00333	0	24	85									
GPC5	2262	broad.mit.edu	37	13	92560309	92560309	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr13:92560309C>T	uc010tif.1	+	6	1765	c.1399C>T	c.(1399-1401)CAG>TAG	p.Q467*		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	467						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				GCATGTTGTTCAGGTAAGTCC	0.313		NaN											0	0	0	0.00308	0	7	14									
GPC6	10082	broad.mit.edu	37	13	93879779	93879779	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr13:93879779G>A	uc001vlt.2	+	1	702	c.70G>A	c.(70-72)GAT>AAT	p.D24N	GPC6_uc010tig.1_Missense_Mutation_p.D24N	NM_005708	NP_005699	Q9Y625	GPC6_HUMAN	glypican 6 precursor	24						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				CGCCGGGGCGGATGTGAAGGC	0.632		NaN									OREG0022460	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.000978	0	12	41									
UGGT2	55757	broad.mit.edu	37	13	96506627	96506627	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr13:96506627G>T	uc001vmt.2	-	35	4281	c.4111C>A	c.(4111-4113)CGT>AGT	p.R1371S	UGGT2_uc001vms.2_Missense_Mutation_p.R91S	NM_020121	NP_064506	Q9NYU1	UGGG2_HUMAN	UDP-glucose ceramide glucosyltransferase-like 2	1371	Glucosyltransferase.				post-translational protein modification|protein folding|protein N-linked glycosylation via asparagine	endoplasmic reticulum lumen|ER-Golgi intermediate compartment	UDP-glucose:glycoprotein glucosyltransferase activity			ovary(2)|central_nervous_system(1)	3						TTCCAGAAACGATATCCATCC	0.393		NaN											1	0	0.000442599	0.006214	0.000766963	9	31									
ZNF828	283489	broad.mit.edu	37	13	115090045	115090045	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr13:115090045C>T	uc010ahb.2	+	3	1057	c.728C>T	c.(727-729)TCA>TTA	p.S243L	ZNF828_uc001vuv.2_Missense_Mutation_p.S243L|ZNF828_uc010tko.1_Missense_Mutation_p.S243L	NM_001164144	NP_001157616	Q96JM3	ZN828_HUMAN	zinc finger protein 828	243	Pro-rich.				attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|protein localization to kinetochore|protein localization to microtubule|sister chromatid biorientation	condensed chromosome kinetochore|cytoplasm|nucleus|spindle	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_epithelial(44;0.122)|all_lung(25;0.123)	BRCA - Breast invasive adenocarcinoma(86;0.104)	OV - Ovarian serous cystadenocarcinoma(48;0.193)|Epithelial(10;0.197)		CCTTCAGCCTCATCTCCAGAG	0.552		NaN											0	0	0	0.00623	0	40	67									
OR4M1	441670	broad.mit.edu	37	14	20248955	20248955	+	Silent	SNP	A	A	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr14:20248955A>T	uc010tku.1	+	1	474	c.474A>T	c.(472-474)ATA>ATT	p.I158I		NM_001005500	NP_001005500	Q8NGD0	OR4M1_HUMAN	olfactory receptor, family 4, subfamily M,	158	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ATTCTATAATACAGGTGGCTC	0.502		NaN											0	0	0	0.006999	0	38	292									
TGM1	7051	broad.mit.edu	37	14	24729739	24729739	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr14:24729739C>A	uc001wod.2	-	4	798	c.674G>T	c.(673-675)CGC>CTC	p.R225L	TGM1_uc010tog.1_Intron	NM_000359	NP_000350	P22735	TGM1_HUMAN	transglutaminase 1	225			R -> P (in ARCI-TGM1).|R -> H (in ARCI-TGM1).		cell envelope organization|keratinization|peptide cross-linking	cornified envelope|intrinsic to membrane	acyltransferase activity|metal ion binding|protein binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(2)|ovary(1)	3				GBM - Glioblastoma multiforme(265;0.0186)	L-Glutamine(DB00130)	TGATTGTGTGCGGACTGTGAA	0.587		NaN											1	0	1.2644e-06	0.001523	2.26604e-06	20	64									
FANCM	57697	broad.mit.edu	37	14	45642298	45642298	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr14:45642298C>G	uc001wwd.3	+	13	2300	c.2201C>G	c.(2200-2202)TCT>TGT	p.S734C	FANCM_uc010anf.2_Missense_Mutation_p.S708C|FANCM_uc001wwe.3_Missense_Mutation_p.S270C|FANCM_uc010ang.2_5'Flank	NM_020937	NP_065988	Q8IYD8	FANCM_HUMAN	Fanconi anemia, complementation group M	734					DNA repair	Fanconi anaemia nuclear complex	ATP binding|ATP-dependent helicase activity|chromatin binding|DNA binding|nuclease activity|protein binding			ovary(3)|lung(2)|breast(2)	7						CTCTCTCTCTCTGAATGGAGA	0.363		NaN						Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.002299	0	22	42									
PYGL	5836	broad.mit.edu	37	14	51378884	51378884	+	Silent	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr14:51378884C>T	uc001wyu.2	-	14	1885	c.1758G>A	c.(1756-1758)ACG>ACA	p.T586T	PYGL_uc010tqq.1_Silent_p.T552T|PYGL_uc001wyv.2_Silent_p.T260T	NM_002863	NP_002854	P06737	PYGL_HUMAN	liver glycogen phosphorylase isoform 1	586					glucose homeostasis|glucose metabolic process|glycogen catabolic process	cytosol|soluble fraction	AMP binding|ATP binding|bile acid binding|drug binding|glucose binding|glycogen phosphorylase activity|protein homodimerization activity|purine base binding|pyridoxal phosphate binding			skin(1)	1	all_epithelial(31;0.00825)|Breast(41;0.148)				Adenosine monophosphate(DB00131)|Pyridoxal Phosphate(DB00114)|Riboflavin(DB00140)	GGTTGTACATCGTGATCACAT	0.512		NaN											0	0	0	0.001786	0	32	95									
KCNH5	27133	broad.mit.edu	37	14	63447854	63447854	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr14:63447854G>C	uc001xfx.2	-	6	729	c.678C>G	c.(676-678)TTC>TTG	p.F226L	KCNH5_uc001xfy.2_Missense_Mutation_p.F226L|KCNH5_uc001xfz.1_Missense_Mutation_p.F168L|KCNH5_uc001xga.2_Missense_Mutation_p.F168L	NM_139318	NP_647479	Q8NCM2	KCNH5_HUMAN	potassium voltage-gated channel, subfamily H,	226	Helical; Name=Segment S1; (Potential).				regulation of transcription, DNA-dependent	integral to membrane	calmodulin binding|two-component sensor activity|voltage-gated potassium channel activity			ovary(4)|skin(4)|central_nervous_system(1)	9				OV - Ovarian serous cystadenocarcinoma(108;0.00958)|BRCA - Breast invasive adenocarcinoma(234;0.168)		TGGCGGTGTAGAAGGTAAGAA	0.388		NaN											0	0	0	0.007291	0	26	29									
SYNE2	23224	broad.mit.edu	37	14	64588835	64588835	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr14:64588835C>G	uc001xgm.2	+	69	13494	c.13264C>G	c.(13264-13266)CAG>GAG	p.Q4422E	SYNE2_uc001xgl.2_Missense_Mutation_p.Q4422E|SYNE2_uc010apy.2_Missense_Mutation_p.Q807E|SYNE2_uc010apz.1_Missense_Mutation_p.Q314E	NM_015180	NP_055995	Q8WXH0	SYNE2_HUMAN	spectrin repeat containing, nuclear envelope 2	4422	Cytoplasmic (Potential).				centrosome localization|cytoskeletal anchoring at nuclear membrane|nuclear migration along microfilament|positive regulation of cell migration	cytoskeleton|filopodium membrane|focal adhesion|integral to membrane|lamellipodium membrane|mitochondrial part|nuclear outer membrane|nucleoplasm|sarcoplasmic reticulum membrane|SUN-KASH complex|Z disc	actin binding|protein binding			ovary(8)|breast(4)|central_nervous_system(1)|pancreas(1)	14				all cancers(60;0.00153)|OV - Ovarian serous cystadenocarcinoma(108;0.00444)|BRCA - Breast invasive adenocarcinoma(234;0.0681)		CGATACAACTCAGGAATCATC	0.328		NaN											0	0	0	0.006999	0	39	56									
ACTN1	87	broad.mit.edu	37	14	69387726	69387726	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr14:69387726C>T	uc001xkl.2	-	3	647	c.337G>A	c.(337-339)GAA>AAA	p.E113K	ACTN1_uc010ttb.1_Missense_Mutation_p.E48K|ACTN1_uc001xkm.2_Missense_Mutation_p.E113K|ACTN1_uc001xkn.2_Missense_Mutation_p.E113K|ACTN1_uc001xko.1_Missense_Mutation_p.E48K|ACTN1_uc010ttd.1_Missense_Mutation_p.E92K	NM_001102	NP_001093	P12814	ACTN1_HUMAN	actinin, alpha 1 isoform b	113	CH 1.|Actin-binding.				focal adhesion assembly|negative regulation of cellular component movement|platelet activation|platelet degranulation|regulation of apoptosis	actin cytoskeleton|cytosol|extracellular region|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|sarcomere	actin binding|calcium ion binding|integrin binding|vinculin binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00605)|all cancers(60;0.00846)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		GCCTTACCTTCGGCTCCGATG	0.557		NaN											0	0	0	0.008361	0	28	99									
ANGEL1	23357	broad.mit.edu	37	14	77273020	77273020	+	Silent	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr14:77273020G>A	uc001xsv.2	-	5	1232	c.1119C>T	c.(1117-1119)CTC>CTT	p.L373L	ANGEL1_uc010tvf.1_Intron	NM_015305	NP_056120	Q9UNK9	ANGE1_HUMAN	angel homolog 1	373										ovary(2)|central_nervous_system(1)|skin(1)	4			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0285)		CTTCTGGGACGAGTGGTTGCA	0.577		NaN											0	0	0	0.00361	0	62	72									
SERPINA4	5267	broad.mit.edu	37	14	95033521	95033521	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr14:95033521G>C	uc001ydk.2	+	3	930	c.864G>C	c.(862-864)GAG>GAC	p.E288D	SERPINA4_uc010avd.2_Missense_Mutation_p.E325D|SERPINA4_uc001ydl.2_Missense_Mutation_p.E288D	NM_006215	NP_006206	P29622	KAIN_HUMAN	serine (or cysteine) proteinase inhibitor, clade	288					regulation of proteolysis	extracellular space	serine-type endopeptidase inhibitor activity			ovary(3)|skin(1)	4				COAD - Colon adenocarcinoma(157;0.211)		AAATGAGGGAGATTGAAGAGG	0.468		NaN											0	0	0	0.003163	0	15	27									
CLMN	79789	broad.mit.edu	37	14	95669499	95669499	+	Silent	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr14:95669499G>A	uc001yef.2	-	9	2303	c.2187C>T	c.(2185-2187)TTC>TTT	p.F729F		NM_024734	NP_079010	Q96JQ2	CLMN_HUMAN	calmin	729						integral to membrane	actin binding				0				Epithelial(152;0.193)		CATAGTGTGGGAAATAGAAGA	0.522		NaN											0	0	0	0.006122	0	18	42									
CTDSPL2	51496	broad.mit.edu	37	15	44788618	44788618	+	Silent	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr15:44788618G>A	uc001ztr.2	+	6	1148	c.732G>A	c.(730-732)GCG>GCA	p.A244A	CTDSPL2_uc001zts.2_Silent_p.A244A|CTDSPL2_uc001ztt.2_Silent_p.A244A|CTDSPL2_uc010bdv.2_Silent_p.A172A	NM_016396	NP_057480	Q05D32	CTSL2_HUMAN	CTD (carboxy-terminal domain, RNA polymerase II,	244							phosphoprotein phosphatase activity				0		all_cancers(109;4.36e-14)|all_epithelial(112;9.8e-12)|Lung NSC(122;1.66e-07)|all_lung(180;1.47e-06)|Melanoma(134;0.0122)		all cancers(107;1.02e-20)|GBM - Glioblastoma multiforme(94;1.49e-06)|COAD - Colon adenocarcinoma(120;0.0857)|Colorectal(105;0.0905)		CAGCCCACGCGGAGGCCACCT	0.363		NaN											0	0	0	0.003163	0	14	34									
ATP8B4	79895	broad.mit.edu	37	15	50152596	50152596	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr15:50152596G>C	uc001zxu.2	-	28	3516	c.3374C>G	c.(3373-3375)TCA>TGA	p.S1125*	ATP8B4_uc010ber.2_Nonsense_Mutation_p.S998*|ATP8B4_uc010ufd.1_Nonsense_Mutation_p.S935*|ATP8B4_uc010ufe.1_RNA|ATP8B4_uc001zxt.2_Nonsense_Mutation_p.S128*	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	1125	Cytoplasmic (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		AGACCTTCTTGAGCTTGACCT	0.522		NaN											0	0	0	0.001523	0	21	55									
ATP8B4	79895	broad.mit.edu	37	15	50189570	50189570	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr15:50189570G>C	uc001zxu.2	-	23	2758	c.2616C>G	c.(2614-2616)TTC>TTG	p.F872L	ATP8B4_uc010ber.2_Missense_Mutation_p.F745L|ATP8B4_uc010ufd.1_Missense_Mutation_p.F682L|ATP8B4_uc010ufe.1_RNA|ATP8B4_uc001zxv.1_Missense_Mutation_p.F170L	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	872	Helical; (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		AATAGCATAAGAATTTGCACA	0.378		NaN											0	0	0	0.00361	0	68	140									
HDC	3067	broad.mit.edu	37	15	50535004	50535004	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr15:50535004G>A	uc001zxz.2	-	12	1548	c.1442C>T	c.(1441-1443)TCC>TTC	p.S481F	HDC_uc001zxy.2_Missense_Mutation_p.S224F|HDC_uc010uff.1_Missense_Mutation_p.S448F	NM_002112	NP_002103	P19113	DCHS_HUMAN	histidine decarboxylase	481					catecholamine biosynthetic process|histidine metabolic process		histidine decarboxylase activity			large_intestine(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6		all_lung(180;0.0138)		all cancers(107;1.12e-06)|GBM - Glioblastoma multiforme(94;9.95e-05)	L-Histidine(DB00117)|Pyridoxal Phosphate(DB00114)	GCTGGGTTGGGAAGTACAGTG	0.552		NaN											0	0	0	0.001368	0	13	31									
IGDCC3	9543	broad.mit.edu	37	15	65667594	65667594	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr15:65667594C>A	uc002aos.2	-	2	502	c.250G>T	c.(250-252)GAG>TAG	p.E84*		NM_004884	NP_004875	Q8IVU1	IGDC3_HUMAN	putative neuronal cell adhesion molecule	84	Extracellular (Potential).|Ig-like C2-type 1.									ovary(3)	3						TGGGTACTCTCTGGCAGCTCT	0.602		NaN											1	0	1.04858e-14	0.006214	1.96073e-14	9	23									
KIF23	9493	broad.mit.edu	37	15	69728485	69728485	+	Missense_Mutation	SNP	G	G	A	rs149564859		TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr15:69728485G>A	uc002asb.2	+	13	1398	c.1281G>A	c.(1279-1281)ATG>ATA	p.M427I	KIF23_uc002asc.2_Missense_Mutation_p.M427I|KIF23_uc010bii.2_Missense_Mutation_p.M317I|KIF23_uc010ukc.1_Missense_Mutation_p.M244I|KIF23_uc010bih.1_RNA	NM_138555	NP_612565	Q02241	KIF23_HUMAN	kinesin family member 23 isoform 1	427					blood coagulation|cytokinesis|microtubule-based movement|mitosis|mitotic spindle elongation	cytosol|kinesin complex|microtubule|midbody|nucleoplasm|spindle	ATP binding|microtubule motor activity|protein binding				0						AGCAAGTCATGAGATTTGCGG	0.368		NaN											0	0	0	0.00499	0	15	44									
THSD4	79875	broad.mit.edu	37	15	72039333	72039333	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr15:72039333C>G	uc002atb.1	+	12	2272	c.2193C>G	c.(2191-2193)TGC>TGG	p.C731W	THSD4_uc002ate.2_Missense_Mutation_p.C371W	NM_024817	NP_079093	Q6ZMP0	THSD4_HUMAN	thrombospondin, type I, domain containing 4	731	TSP type-1 2.					proteinaceous extracellular matrix	metalloendopeptidase activity			ovary(2)	2						CCAGCACCTGCCAACTCAAGA	0.657		NaN											0	0	0	0.006214	0	7	12									
ISLR2	57611	broad.mit.edu	37	15	74425108	74425108	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr15:74425108C>T	uc002axd.2	+	4	782	c.13C>T	c.(13-15)CGG>TGG	p.R5W	ISLR2_uc002axe.2_Missense_Mutation_p.R5W|ISLR2_uc010bjg.2_Missense_Mutation_p.R5W|ISLR2_uc010bjf.2_Missense_Mutation_p.R5W	NM_001130136	NP_001123608	Q6UXK2	ISLR2_HUMAN	immunoglobulin superfamily containing	5					positive regulation of axon extension	cell surface|integral to membrane|plasma membrane					0						GTTCCCCCTTCGGGCCCTGTG	0.622		NaN											0	0	0	0.001855	0	12	24									
DNAJA4	55466	broad.mit.edu	37	15	78566699	78566699	+	Silent	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr15:78566699C>T	uc002bdj.1	+	4	696	c.579C>T	c.(577-579)CGC>CGT	p.R193R	DNAJA4_uc002bdi.2_Silent_p.R222R|DNAJA4_uc002bdk.2_Silent_p.R166R|DNAJA4_uc002bdl.2_Silent_p.R108R|DNAJA4_uc002bdm.1_5'Flank	NM_001130182	NP_001123654	Q8WW22	DNJA4_HUMAN	DnaJ (Hsp40) homolog, subfamily A, member 4	193	CR-type.				protein folding|response to heat	membrane	ATP binding|heat shock protein binding|metal ion binding|unfolded protein binding			skin(1)	1						CCAAGGACCGCTGCGAGAGCT	0.597		NaN											0	0	0	0.006122	0	18	36									
FSD2	123722	broad.mit.edu	37	15	83447543	83447543	+	Silent	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr15:83447543C>T	uc002bjd.2	-	6	1253	c.1086G>A	c.(1084-1086)CTG>CTA	p.L362L	FSD2_uc010uol.1_Silent_p.L362L|FSD2_uc010uom.1_Silent_p.L362L	NM_001007122	NP_001007123	A1L4K1	FSD2_HUMAN	fibronectin type III and SPRY domain containing	362										central_nervous_system(1)	1						TGGAGCCCATCAGCTGCTCCA	0.423		NaN											0	0	0	0.004482	0	9	17									
ACAN	176	broad.mit.edu	37	15	89402347	89402347	+	Silent	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr15:89402347G>A	uc010upo.1	+	12	6905	c.6531G>A	c.(6529-6531)GTG>GTA	p.V2177V	ACAN_uc010upp.1_Silent_p.V2177V|ACAN_uc002bna.2_RNA	NM_013227	NP_037359	E7EX88	E7EX88_HUMAN	aggrecan isoform 2 precursor	2177					cell adhesion		hyaluronic acid binding|sugar binding			ovary(2)|central_nervous_system(1)	3	Lung NSC(78;0.0392)|all_lung(78;0.077)		BRCA - Breast invasive adenocarcinoma(143;0.146)			CCAGTGATGTGGGGACAGAGG	0.607		NaN											0	0	0	0.007413	0	19	60									
PDIA2	64714	broad.mit.edu	37	16	335191	335191	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr16:335191C>G	uc002cgn.1	+	10	1894	c.786C>G	c.(784-786)TTC>TTG	p.F262L	PDIA2_uc010bqt.1_Missense_Mutation_p.F107L|PDIA2_uc002cgo.1_Missense_Mutation_p.F262L	NM_006849	NP_006840	Q13087	PDIA2_HUMAN	protein disulfide isomerase A2 precursor	262					apoptosis|cell redox homeostasis|glycerol ether metabolic process|protein folding|protein retention in ER lumen|response to hypoxia	endoplasmic reticulum lumen	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity|steroid binding			central_nervous_system(1)|skin(1)	2		all_cancers(16;6.71e-07)|all_epithelial(16;1.59e-06)|Hepatocellular(16;0.000105)|Lung NSC(18;0.00769)|all_lung(18;0.0186)				TCACGGAGTTCAACAGCCAGG	0.662		NaN											0	0	0	0.001984	0	7	29									
CHTF18	63922	broad.mit.edu	37	16	844108	844108	+	Silent	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr16:844108C>T	uc002cke.3	+	15	1920	c.1857C>T	c.(1855-1857)GAC>GAT	p.D619D	CHTF18_uc002ckf.3_Silent_p.D647D|CHTF18_uc010brf.2_Silent_p.D201D|CHTF18_uc002ckg.3_Silent_p.D137D	NM_022092	NP_071375	Q8WVB6	CTF18_HUMAN	CTF18, chromosome transmission fidelity factor	619					cell cycle|DNA replication	nucleus	ATP binding|DNA binding|nucleoside-triphosphatase activity			kidney(1)	1		Hepatocellular(780;0.00335)				TGCTGGGTGACGGGGACGCGG	0.662		NaN											0	0	0	0.001855	0	13	56									
TBC1D24	57465	broad.mit.edu	37	16	2546212	2546212	+	Silent	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr16:2546212C>T	uc002cql.2	+	2	203	c.63C>T	c.(61-63)GAC>GAT	p.D21D	TBC1D24_uc002cqk.2_Silent_p.D21D|TBC1D24_uc002cqm.2_Silent_p.D21D|TBC1D24_uc010bsm.2_5'Flank	NM_020705	NP_065756	Q9ULP9	TBC24_HUMAN	TBC1 domain family, member 24	21					neuron projection development	cytoplasm	protein binding|Rab GTPase activator activity				0						CCATCCAGGACCTGGGGCCCA	0.637		NaN											0	0	0	0.008871	0	20	36									
TBC1D24	57465	broad.mit.edu	37	16	2546956	2546956	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr16:2546956C>G	uc002cql.2	+	2	947	c.807C>G	c.(805-807)ATC>ATG	p.I269M	TBC1D24_uc002cqk.2_Missense_Mutation_p.I269M|TBC1D24_uc002cqm.2_Missense_Mutation_p.I269M|TBC1D24_uc010bsm.2_5'Flank	NM_020705	NP_065756	Q9ULP9	TBC24_HUMAN	TBC1 domain family, member 24	269					neuron projection development	cytoplasm	protein binding|Rab GTPase activator activity				0						AGCAGGACATCCGCACGTTCG	0.622		NaN											0	0	0	0.006122	0	14	54									
TBC1D24	57465	broad.mit.edu	37	16	2546965	2546965	+	Silent	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr16:2546965C>T	uc002cql.2	+	2	956	c.816C>T	c.(814-816)TTC>TTT	p.F272F	TBC1D24_uc002cqk.2_Silent_p.F272F|TBC1D24_uc002cqm.2_Silent_p.F272F|TBC1D24_uc010bsm.2_5'Flank	NM_020705	NP_065756	Q9ULP9	TBC24_HUMAN	TBC1 domain family, member 24	272					neuron projection development	cytoplasm	protein binding|Rab GTPase activator activity				0						TCCGCACGTTCGTCAGAGACA	0.622		NaN											0	0	0	0.004007	0	14	50									
TNRC6A	27327	broad.mit.edu	37	16	24816470	24816470	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr16:24816470C>T	uc002dmm.2	+	14	4234	c.4120C>T	c.(4120-4122)CAG>TAG	p.Q1374*	TNRC6A_uc010bxs.2_Nonsense_Mutation_p.Q1121*|TNRC6A_uc002dmn.2_Nonsense_Mutation_p.Q1072*|TNRC6A_uc002dmo.2_Nonsense_Mutation_p.Q1013*|TNRC6A_uc002dmp.2_5'UTR|TNRC6A_uc002dmq.2_Nonsense_Mutation_p.Q41*	NM_014494	NP_055309	Q8NDV7	TNR6A_HUMAN	trinucleotide repeat containing 6A	1374					negative regulation of translation involved in gene silencing by miRNA	cytoplasmic mRNA processing body|micro-ribonucleoprotein complex	nucleotide binding|RNA binding			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0394)		ACTCTCCCCTCAGGTAAATAA	0.438		NaN											0	0	0	0.007291	0	27	76									
GTF3C1	2975	broad.mit.edu	37	16	27475748	27475748	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr16:27475748G>A	uc002dov.1	-	34	5805	c.5765C>T	c.(5764-5766)GCG>GTG	p.A1922V	GTF3C1_uc002dou.2_Missense_Mutation_p.A1922V	NM_001520	NP_001511	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide	1922						transcription factor TFIIIC complex	DNA binding|protein binding			ovary(2)|pancreas(1)|breast(1)|skin(1)	5						TGCTGCTCCCGCTGCAGCGGT	0.642		NaN											0	0	0	0.00361	0	46	120									
SH2B1	25970	broad.mit.edu	37	16	28878727	28878727	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr16:28878727G>C	uc002dri.2	+	5	1454	c.1015G>C	c.(1015-1017)GAC>CAC	p.D339H	uc010vct.1_Intron|SH2B1_uc010vdc.1_Missense_Mutation_p.D29H|SH2B1_uc002drj.2_Missense_Mutation_p.D339H|SH2B1_uc002drk.2_Missense_Mutation_p.D339H|SH2B1_uc002drl.2_Missense_Mutation_p.D339H|SH2B1_uc010vdd.1_Missense_Mutation_p.D3H|SH2B1_uc010vde.1_Missense_Mutation_p.D339H|SH2B1_uc002drm.2_Missense_Mutation_p.D339H	NM_001145795	NP_001139267	Q9NRF2	SH2B1_HUMAN	SH2B adaptor protein 1 isoform 1	339	Interaction with JAK2 (low-affinity binding; independent of JAK2 phosphorylation) (By similarity).|PH.				blood coagulation|intracellular signal transduction	cytosol|membrane|nucleus	signal transducer activity			ovary(2)	2						GGAGATGCCTGACCGGGAGAA	0.547		NaN											0	0	0	0.00361	0	53	145									
MVP	9961	broad.mit.edu	37	16	29852959	29852959	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr16:29852959G>A	uc002dui.2	+	9	1318	c.1234G>A	c.(1234-1236)GAA>AAA	p.E412K	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|MVP_uc010vdz.1_RNA|MVP_uc002duj.2_Missense_Mutation_p.E412K|MVP_uc010vea.1_Missense_Mutation_p.E6K	NM_005115	NP_005106	Q14764	MVP_HUMAN	major vault protein	412	MVP 8.				mRNA transport|protein transport|response to drug|transmembrane transport	cytoplasm|nuclear pore|ribonucleoprotein complex	protein binding			skin(2)|ovary(1)|central_nervous_system(1)	4						GACCCAGGACGAAGTCCTGTG	0.617		NaN											0	0	0	0.001368	0	12	20									
ZNF768	79724	broad.mit.edu	37	16	30535908	30535908	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr16:30535908C>T	uc002dyk.3	-	2	1729	c.1553G>A	c.(1552-1554)TGC>TAC	p.C518Y	ZNF768_uc010vex.1_Missense_Mutation_p.C487Y|uc002dyl.1_5'Flank|ZNF768_uc010vew.1_Missense_Mutation_p.C487Y	NM_024671	NP_078947	Q9H5H4	ZN768_HUMAN	zinc finger protein 768	518	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	DNA-directed RNA polymerase II, core complex	DNA binding|zinc ion binding				0						GGCCTTTCCGCAGTCATCGCA	0.692		NaN											0	0	0	0.001368	0	11	32									
OGFOD1	55239	broad.mit.edu	37	16	56509430	56509430	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr16:56509430G>A	uc002ejb.2	+	12	1521	c.1420G>A	c.(1420-1422)GAA>AAA	p.E474K	OGFOD1_uc002ejc.2_Missense_Mutation_p.E334K	NM_018233	NP_060703	Q8N543	OGFD1_HUMAN	2-oxoglutarate and iron-dependent oxygenase	474							iron ion binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			skin(1)	1					Vitamin C(DB00126)	CTGGGAGCCAGAATATGGCGG	0.383		NaN											0	0	0	0.00361	0	41	63									
SLC9A5	6553	broad.mit.edu	37	16	67298323	67298323	+	Silent	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr16:67298323C>T	uc002esm.2	+	13	1974	c.1911C>T	c.(1909-1911)TTC>TTT	p.F637F	SLC9A5_uc010cee.2_Silent_p.F342F|SLC9A5_uc010vji.1_Silent_p.F141F	NM_004594	NP_004585	Q14940	SL9A5_HUMAN	solute carrier family 9 (sodium/hydrogen	637					regulation of pH	integral to membrane|plasma membrane	sodium:hydrogen antiporter activity			ovary(1)|pancreas(1)	2		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.00376)|Epithelial(162;0.0173)|all cancers(182;0.116)		AGGAGGTCTTCCAGCAGAACA	0.587		NaN											0	0	0	0.006214	0	8	20									
CTCF	10664	broad.mit.edu	37	16	67654676	67654676	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr16:67654676G>A	uc002etl.2	+	6	1453	c.1163G>A	c.(1162-1164)AGC>AAC	p.S388N	CTCF_uc010cek.2_Missense_Mutation_p.S60N	NM_006565	NP_006556	P49711	CTCF_HUMAN	CCCTC-binding factor	388	C2H2-type 5.				chromatin modification|chromosome segregation|negative regulation of transcription, DNA-dependent|nucleosome positioning|positive regulation of transcription, DNA-dependent|regulation of centromeric sister chromatid cohesion|regulation of molecular function, epigenetic	chromosome, centromeric region|condensed chromosome|nucleolus|nucleoplasm	chromatin insulator sequence binding|protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0166)|Epithelial(162;0.0577)		AGTTATGCCAGCAGGGACACA	0.443		NaN											0	0	0	0.001523	0	22	52									
ACD	65057	broad.mit.edu	37	16	67692069	67692069	+	Silent	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr16:67692069C>T	uc002etq.3	-	10	1621	c.1284G>A	c.(1282-1284)CAG>CAA	p.Q428Q	ACD_uc002etp.3_Silent_p.Q425Q|ACD_uc002etr.3_Silent_p.Q425Q|ACD_uc010vjt.1_3'UTR|PARD6A_uc002ets.2_5'Flank|PARD6A_uc002ett.2_5'Flank	NM_001082486	NP_001075955	Q96AP0	ACD_HUMAN	adrenocortical dysplasia homolog isoform 1	428	Ser-rich.				intracellular protein transport|negative regulation of telomere maintenance via telomerase|positive regulation of single-stranded telomeric DNA binding|positive regulation of telomerase activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|telomere assembly	nuclear telomere cap complex|nucleoplasm	DNA binding|DNA polymerase binding			pancreas(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		GAGTGCAGCTCTGGAGTGGGG	0.642		NaN											0	0	0	0.00499	0	13	29									
SPIRE2	84501	broad.mit.edu	37	16	89895104	89895104	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr16:89895104G>A	uc002foz.1	+	1	198	c.146G>A	c.(145-147)CGC>CAC	p.R49H	SPIRE2_uc010civ.1_5'UTR|SPIRE2_uc010ciw.1_Missense_Mutation_p.R49H	NM_032451	NP_115827	Q8WWL2	SPIR2_HUMAN	spire homolog 2	49	KIND.				transport	cytoplasm|cytoskeleton	actin binding			central_nervous_system(1)	1		Lung NSC(15;5.15e-06)|all_lung(18;8.38e-06)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0286)		CAGGGCTGCCGCGGGCTGCGG	0.552		NaN											0	0	0	0.000602	0	4	8									
ITGAE	3682	broad.mit.edu	37	17	3661136	3661136	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr17:3661136G>C	uc002fwo.3	-	9	983	c.884C>G	c.(883-885)TCA>TGA	p.S295*		NM_002208	NP_002199	P38570	ITAE_HUMAN	integrin, alpha E precursor	295	VWFA.|Extracellular (Potential).				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			large_intestine(2)|breast(1)|pancreas(1)	4				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		GCCGTGGCTTGAGGTGAAGAT	0.522		NaN											0	0	0	0.002522	0	44	56									
TP53	7157	broad.mit.edu	37	17	7577548	7577548	+	Missense_Mutation	SNP	C	C	T	rs28934575		TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08			C	T	C	C		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr17:7577548C>T	uc002gim.2	-	7	927	c.733G>A	c.(733-735)GGC>AGC	p.G245S	TP53_uc002gig.1_Missense_Mutation_p.G245S|TP53_uc002gih.2_Missense_Mutation_p.G245S|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.G113S|TP53_uc010cng.1_Missense_Mutation_p.G113S|TP53_uc002gii.1_Missense_Mutation_p.G113S|TP53_uc010cnh.1_Missense_Mutation_p.G245S|TP53_uc010cni.1_Missense_Mutation_p.G245S|TP53_uc002gij.2_Missense_Mutation_p.G245S|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.G152S|TP53_uc002gio.2_Missense_Mutation_p.G113S	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	245	|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.|Interaction with AXIN1 (By similarity).		G -> N (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> A (in sporadic cancers; somatic mutation).|G -> V (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> F (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> R (in sporadic cancers; somatic mutation).|G -> E (in a sporadic cancer; somatic mutation).|G -> D (in LFS; germline mutation and in sporadic cancers; somatic mutation).|G -> H (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|G -> L (in sporadic cancers; somatic mutation; requires 2 nucleotide substitutions).|G -> C (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.G245S(274)|p.G245D(93)|p.G245V(50)|p.G245C(47)|p.G245R(10)|p.G245A(8)|p.0?(7)|p.G245G(3)|p.G245fs*2(3)|p.G245N(2)|p.G245H(1)|p.G245L(1)|p.G244fs*17(1)|p.G245F(1)|p.G245E(1)|p.C242_M246>L(1)|p.C238_M246delCNSSCMGGM(1)|p.S241_G245delSCMGG(1)|p.C242fs*98(1)|p.G245fs*22(1)|p.M243fs*18(1)|p.G245del(1)|p.G245fs*14(1)|p.G245fs*17(1)|p.G245fs*16(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CGGTTCATGCCGCCCATGCAG	0.577	G245S(SKLMS1_SOFT_TISSUE)|G245S(LS1034_LARGE_INTESTINE)|G245S(NUGC2_STOMACH)|G245S(PANC0403_PANCREAS)|G245S(SKMEL2_SKIN)	111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			0	0	0	0.007291	0	25	23									
MAP2K3	5606	broad.mit.edu	37	17	21204234	21204234	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr17:21204234G>A	uc002gys.2	+	5	593	c.328G>A	c.(328-330)GAC>AAC	p.D110N	MAP2K3_uc002gyt.2_Missense_Mutation_p.D81N|MAP2K3_uc002gyu.2_Missense_Mutation_p.D81N	NM_145109	NP_659731	P46734	MP2K3_HUMAN	mitogen-activated protein kinase kinase 3	110	Protein kinase.				activation of MAPK activity|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of transcription, DNA-dependent|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|MAP kinase kinase activity|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity				0				COAD - Colon adenocarcinoma(3;0.0131)|Colorectal(15;0.0553)		GCTGCTCATGGACCTGGACAT	0.587		NaN											0	0	0	0.008291	0	11	80									
CSF3	1440	broad.mit.edu	37	17	38173107	38173107	+	Silent	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr17:38173107C>T	uc002htp.2	+	5	559	c.519C>T	c.(517-519)TTC>TTT	p.F173F	CSF3_uc002hto.2_Silent_p.F170F|CSF3_uc002htq.2_Silent_p.F166F|CSF3_uc010wep.1_Silent_p.F130F	NM_000759	NP_000750	P09919	CSF3_HUMAN	colony stimulating factor 3 isoform a precursor	173					cytokine-mediated signaling pathway|granulocyte differentiation|immune response|positive regulation of cell proliferation	extracellular space	cytokine activity|enzyme binding|granulocyte colony-stimulating factor receptor binding|growth factor activity			ovary(1)	1	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Filgrastim(DB00099)|Pegfilgrastim(DB00019)	TGCCGGCCTTCGCCTCTGCTT	0.647		NaN											0	0	0	0.004656	0	25	45									
NR1D1	9572	broad.mit.edu	37	17	38253437	38253437	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr17:38253437G>C	uc002htz.1	-	2	877	c.251C>G	c.(250-252)TCA>TGA	p.S84*	NR1D1_uc010cwq.1_RNA|NR1D1_uc010cwr.1_5'Flank	NM_021724	NP_068370	P20393	NR1D1_HUMAN	nuclear receptor subfamily 1, group D, member 1	84	Poly-Ser.				cellular response to lipopolysaccharide|negative regulation of receptor biosynthetic process|negative regulation of toll-like receptor 4 signaling pathway|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nuclear chromatin|nucleoplasm	sequence-specific DNA binding|steroid hormone receptor activity|transcription corepressor activity|transcription regulatory region DNA binding|zinc ion binding			skin(1)	1	Colorectal(19;0.000442)					cgaggaagatgaggaagaagg	0.478		NaN											0	0	0	0.00245	0	15	38									
TNS4	84951	broad.mit.edu	37	17	38645050	38645050	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr17:38645050G>C	uc010cxb.2	-	3	775	c.611C>G	c.(610-612)TCT>TGT	p.S204C		NM_032865	NP_116254	Q8IZW8	TENS4_HUMAN	tensin 4 precursor	204	Ser-rich.				apoptosis|protein localization	cytoplasm|cytoskeleton|focal adhesion	actin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(5;5.91e-05)			CTGGTTCCCAGAGAAGATGAG	0.647		NaN											0	0	0	0.00278	0	22	44									
KRTAP9-8	83901	broad.mit.edu	37	17	39394660	39394660	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr17:39394660G>C	uc002hwh.3	+	1	391	c.357G>C	c.(355-357)CAG>CAC	p.Q119H	KRTAP9-9_uc010wfq.1_Intron	NM_031963	NP_114169	Q9BYQ0	KRA98_HUMAN	keratin associated protein 9.8	119	15 X 5 AA repeats of C-C-[RQVSGE]- [SPSNQ]-[TASPI].					keratin filament				ovary(1)	1		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000397)			GCCTAAACCAGAGCTGTGGCT	0.622		NaN											0	0	0	0.005524	0	30	66									
BRIP1	83990	broad.mit.edu	37	17	59763374	59763374	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr17:59763374C>G	uc002izk.1	-	19	2869	c.2728G>C	c.(2728-2730)GAA>CAA	p.E910Q	BRIP1_uc002izl.1_Missense_Mutation_p.E291Q	NM_032043	NP_114432	Q9BX63	FANCJ_HUMAN	BRCA1 interacting protein C-terminal helicase 1	910	Interaction with BRCA1.				DNA damage checkpoint|double-strand break repair|regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	ATP binding|ATP-dependent DNA helicase activity|DNA binding|protein binding			ovary(1)	1						GAGGTCACTTCAAGTGTAGAC	0.368		NaN	F|N|Mis			AML|leukemia|breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia				0	0	0	0.00361	0	83	101									
MED13	9969	broad.mit.edu	37	17	60111268	60111268	+	Missense_Mutation	SNP	A	A	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr17:60111268A>T	uc002izo.2	-	5	771	c.694T>A	c.(694-696)TTA>ATA	p.L232I		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	232					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						TCACCAATTAATTTTTTTGTA	0.383		NaN											0	0	0	0.00499	0	17	49									
ABCA9	10350	broad.mit.edu	37	17	66988371	66988371	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr17:66988371G>A	uc002jhu.2	-	28	3804	c.3661C>T	c.(3661-3663)CGA>TGA	p.R1221*	ABCA9_uc010dez.2_Nonsense_Mutation_p.R1183*	NM_080283	NP_525022	Q8IUA7	ABCA9_HUMAN	ATP-binding cassette, sub-family A, member 9	1221					transport	integral to membrane	ATP binding|ATPase activity			ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6	Breast(10;1.47e-12)					TCTAGGCATCGCAGAATGAAA	0.318		NaN											0	0	0	0.001168	0	6	20									
OTOP3	347741	broad.mit.edu	37	17	72937560	72937560	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr17:72937560G>A	uc010wrr.1	+	2	146	c.146G>A	c.(145-147)CGA>CAA	p.R49Q	OTOP3_uc010wrq.1_Missense_Mutation_p.R31Q	NM_178233	NP_839947	Q7RTS5	OTOP3_HUMAN	otopetrin 3	49						integral to membrane|intracellular	zinc ion binding			ovary(1)	1	all_lung(278;0.151)|Lung NSC(278;0.185)					AAGGAGAACCGAGTGGATGTG	0.552		NaN											0	0	0	0.000602	0	4	14									
MIF4GD	57409	broad.mit.edu	37	17	73263627	73263627	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr17:73263627C>G	uc002jnr.2	-	5	562	c.433G>C	c.(433-435)GAG>CAG	p.E145Q	MIF4GD_uc002jno.2_Missense_Mutation_p.E186Q|MIF4GD_uc002jnp.2_Missense_Mutation_p.E179Q|MIF4GD_uc002jnq.2_Missense_Mutation_p.E186Q			A9UHW6	MI4GD_HUMAN	RecName: Full=MIF4G domain-containing protein; AltName: Full=SLBP-interacting protein 1;          Short=hSLIP1;	145	MIF4G.				regulation of translation|RNA metabolic process	cytoplasm|nucleus	protein C-terminus binding			ovary(1)	1	all_cancers(13;1.25e-07)|all_epithelial(9;2.63e-08)|Breast(9;1.06e-07)		all cancers(21;3.02e-07)|Epithelial(20;2.92e-06)			ACCTCCTCCTCCTTGCTCAAA	0.612		NaN											0	0	0	0.008871	0	19	62									
TRIM65	201292	broad.mit.edu	37	17	73887139	73887139	+	Silent	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr17:73887139G>C	uc002jpx.2	-	6	1311	c.1275C>G	c.(1273-1275)CTC>CTG	p.L425L		NM_173547	NP_775818	Q6PJ69	TRI65_HUMAN	tripartite motif-containing 65	425	B30.2/SPRY.					intracellular	zinc ion binding				0			Epithelial(20;7.53e-06)|all cancers(21;9.11e-06)|BRCA - Breast invasive adenocarcinoma(9;0.00092)|LUSC - Lung squamous cell carcinoma(166;0.154)			CCTGGACGCAGAGCCCCCAGG	0.687		NaN											0	0	0	0.004482	0	9	19									
TMC6	11322	broad.mit.edu	37	17	76113638	76113638	+	Silent	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr17:76113638C>T	uc002juj.1	-	16	2235	c.2109G>A	c.(2107-2109)GCG>GCA	p.A703A	TMC6_uc002jui.1_Silent_p.A282A|TMC6_uc010dhf.1_Silent_p.A536A|TMC6_uc002juk.2_Silent_p.A703A|TMC6_uc010dhg.1_Intron|TMC6_uc002jul.1_Silent_p.A703A	NM_007267	NP_009198	Q7Z403	TMC6_HUMAN	transmembrane channel-like 6	703	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane					0			BRCA - Breast invasive adenocarcinoma(99;0.00269)|Lung(188;0.0973)			TGGGGCCTGCCGCCTCCAGGT	0.667		NaN							Epidermodysplasia_Verruciformis_Familial_Clustering_of				0	0	0	0.000602	0	4	9									
ACTG1	71	broad.mit.edu	37	17	79479123	79479123	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr17:79479123C>T	uc002kaj.1	-	2	194	c.169G>A	c.(169-171)GAG>AAG	p.E57K	ACTG1_uc002kah.1_5'Flank|ACTG1_uc002kai.1_Missense_Mutation_p.E14K|ACTG1_uc002kak.1_Missense_Mutation_p.E57K|ACTG1_uc010wun.1_Missense_Mutation_p.E57K|ACTG1_uc002kal.1_Missense_Mutation_p.E57K|ACTG1_uc002kag.2_RNA	NM_001614	NP_001605	P63261	ACTG_HUMAN	actin, gamma 1 propeptide	57					adherens junction organization|axon guidance|blood coagulation|cell junction assembly|cellular component movement	cytoskeleton|cytosol	ATP binding|identical protein binding			ovary(1)|central_nervous_system(1)	2	all_neural(118;0.0878)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0282)|OV - Ovarian serous cystadenocarcinoma(97;0.0547)			CTCTGGGCCTCGTCGCCCACG	0.642		NaN											0	0	0	0.00361	0	50	27									
ZNF750	79755	broad.mit.edu	37	17	80788479	80788479	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr17:80788479G>A	uc002kga.2	-	3	2022	c.1711C>T	c.(1711-1713)CGA>TGA	p.R571*	TBCD_uc002kfx.1_Intron|TBCD_uc002kfy.1_Intron|TBCD_uc002kfz.2_Intron	NM_024702	NP_078978	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	571						intracellular	zinc ion binding			central_nervous_system(1)	1	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			GCTCGTGGTCGACCGGGGAAG	0.622		NaN											0	0	0	0.008361	0	23	36									
LAMA3	3909	broad.mit.edu	37	18	21508633	21508633	+	Silent	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr18:21508633C>T	uc002kuq.2	+	64	8426	c.8340C>T	c.(8338-8340)TTC>TTT	p.F2780F	LAMA3_uc002kur.2_Silent_p.F2724F|LAMA3_uc002kus.3_Silent_p.F1171F|LAMA3_uc002kut.3_Silent_p.F1115F	NM_198129	NP_937762	Q16787	LAMA3_HUMAN	laminin alpha 3 subunit isoform 1	2780	Laminin G-like 3.				cell adhesion|epidermis development|hemidesmosome assembly|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|skin(2)|central_nervous_system(1)	11	all_cancers(21;7.81e-05)|all_epithelial(16;4.45e-07)|Lung NSC(20;0.00156)|all_lung(20;0.00508)|Colorectal(14;0.0202)|Ovarian(20;0.17)				Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AATTGAGTTTCACTGATTTGG	0.423		NaN											0	0	0	0.00361	0	50	72									
CD226	10666	broad.mit.edu	37	18	67563226	67563226	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr18:67563226C>G	uc010dqo.2	-	3	885	c.438G>C	c.(436-438)AAG>AAC	p.K146N	CD226_uc002lkm.3_Missense_Mutation_p.K146N	NM_006566	NP_006557	Q15762	CD226_HUMAN	CD226 molecule precursor	146	Ig-like C2-type 2.|Extracellular (Potential).				cell adhesion|cell recognition|positive regulation of Fc receptor mediated stimulatory signaling pathway|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	cell surface|integral to plasma membrane|membrane raft	cell adhesion molecule binding|integrin binding|protein kinase binding|receptor activity				0		Esophageal squamous(42;0.129)				GTGTGACATTCTTTCCAGGTT	0.458		NaN											0	0	0	0.001882	0	18	32									
ADNP2	22850	broad.mit.edu	37	18	77894028	77894028	+	Silent	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr18:77894028G>A	uc002lnw.2	+	4	1187	c.732G>A	c.(730-732)GAG>GAA	p.E244E		NM_014913	NP_055728	Q6IQ32	ADNP2_HUMAN	ADNP homeobox 2	244					cellular response to oxidative stress|cellular response to retinoic acid|negative regulation of cell death|neuron differentiation|positive regulation of cell growth	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|breast(3)|central_nervous_system(1)	8		all_cancers(4;1.06e-15)|all_epithelial(4;2.36e-10)|all_lung(4;0.000302)|Lung NSC(4;0.000518)|Esophageal squamous(42;0.0212)|Ovarian(4;0.0256)|all_hematologic(56;0.15)|Melanoma(33;0.2)		Epithelial(2;1.1e-11)|OV - Ovarian serous cystadenocarcinoma(15;7.54e-09)|BRCA - Breast invasive adenocarcinoma(31;0.00247)|STAD - Stomach adenocarcinoma(84;0.164)		GAGATTTGGAGAATAAGCTTA	0.423		NaN											0	0	0	0.001855	0	14	40									
APC2	10297	broad.mit.edu	37	19	1456894	1456894	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:1456894G>A	uc002lsr.1	+	9	1067	c.859G>A	c.(859-861)GAC>AAC	p.D287N	APC2_uc002lss.1_5'UTR|APC2_uc002lst.1_Missense_Mutation_p.D287N|APC2_uc002lsu.1_Missense_Mutation_p.D286N	NM_005883	NP_005874	O95996	APC2_HUMAN	adenomatosis polyposis coli 2	287					negative regulation of canonical Wnt receptor signaling pathway|negative regulation of catenin import into nucleus|Wnt receptor signaling pathway	actin filament|catenin complex|cytoplasmic microtubule|Golgi membrane|lamellipodium membrane|perinuclear region of cytoplasm	beta-catenin binding|microtubule binding			breast(3)|pancreas(1)	4		Acute lymphoblastic leukemia(61;3.02e-13)|all_hematologic(61;4.32e-09)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GGCGACGCGCGACCAGGAGGA	0.677		NaN											0	0	0	0.000602	0	5	1									
C19orf36	113177	broad.mit.edu	37	19	2097472	2097472	+	Silent	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:2097472C>T	uc002luw.1	+	3	425	c.348C>T	c.(346-348)CTC>CTT	p.L116L	C19orf36_uc002lux.1_Silent_p.L116L|C19orf36_uc010xgw.1_Silent_p.L116L	NM_001039846	NP_001034935	Q1ZYL8	IZUM4_HUMAN	hypothetical protein LOC113177 isoform 3	116						extracellular region					0		Ovarian(11;1.78e-06)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		AGGTGCACCTCATCCAGAACG	0.607		NaN									OREG0025135	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	0	0	0	0.004007	0	15	42									
UHRF1	29128	broad.mit.edu	37	19	4941939	4941939	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:4941939G>C	uc002mbo.2	+	7	1237	c.1069G>C	c.(1069-1071)GAG>CAG	p.E357Q	UHRF1_uc010xik.1_RNA|UHRF1_uc010duf.2_RNA|UHRF1_uc002mbp.2_Missense_Mutation_p.E370Q	NM_001048201	NP_001041666	Q96T88	UHRF1_HUMAN	ubiquitin-like with PHD and ring finger domains	357	PHD-type.				cell cycle|cell proliferation|DNA repair|regulation of transcription from RNA polymerase II promoter	nucleus	acid-amino acid ligase activity|methyl-CpG binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0276)		CAGCGAGGACGAGTGGTGAGT	0.612		NaN											0	0	0	0.004672	0	2	4									
HNRNPM	4670	broad.mit.edu	37	19	8533687	8533687	+	Silent	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:8533687C>T	uc010dwe.2	+	9	944	c.864C>T	c.(862-864)TTC>TTT	p.F288F	HNRNPM_uc010dwc.1_Silent_p.F288F|HNRNPM_uc010xke.1_Silent_p.F249F|HNRNPM_uc010dwd.2_Silent_p.F249F|HNRNPM_uc002mka.2_Silent_p.F168F	NM_005968	NP_005959	P52272	HNRPM_HUMAN	heterogeneous nuclear ribonucleoprotein M	288					alternative nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|integral to plasma membrane|nuclear matrix|nucleolus|paraspeckles	nucleotide binding|protein domain specific binding|RNA binding				0						AAGGAGATTTCTTCCCTCCTG	0.323		NaN											0	0	0	0.00632	0	24	47									
COL5A3	50509	broad.mit.edu	37	19	10116382	10116382	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:10116382C>G	uc002mmq.1	-	4	532	c.446G>C	c.(445-447)CGT>CCT	p.R149P		NM_015719	NP_056534	P25940	CO5A3_HUMAN	collagen, type V, alpha 3 preproprotein	149	TSP N-terminal.				collagen fibril organization|skin development	collagen type V	collagen binding|extracellular matrix structural constituent			ovary(7)|lung(1)|central_nervous_system(1)|skin(1)	10			Epithelial(33;7.11e-05)			GACGGCCACACGGTGCCACCT	0.627		NaN											0	0	0	0.001984	0	7	23									
KEAP1	9817	broad.mit.edu	37	19	10602630	10602630	+	Silent	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:10602630C>T	uc002moq.1	-	3	1104	c.948G>A	c.(946-948)GTG>GTA	p.V316V	KEAP1_uc002mop.1_Silent_p.V34V|KEAP1_uc002mor.1_Silent_p.V316V	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	316					regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding			lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			GGCAGGGCATCACCTGCGTGG	0.637		NaN											0	0	0	0.008291	0	10	36									
KEAP1	9817	broad.mit.edu	37	19	10602926	10602926	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:10602926C>G	uc002moq.1	-	3	808	c.652G>C	c.(652-654)GAG>CAG	p.E218Q	KEAP1_uc002mop.1_5'UTR|KEAP1_uc002mor.1_Missense_Mutation_p.E218Q	NM_012289	NP_036421	Q14145	KEAP1_HUMAN	kelch-like ECH-associated protein 1	218	BACK.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	centrosome|midbody|nucleus	protein binding	p.E218Q(1)		lung(12)|breast(3)|ovary(1)|pancreas(1)	17			OV - Ovarian serous cystadenocarcinoma(20;2.71e-09)|Epithelial(33;2.32e-06)|all cancers(31;1.42e-05)			AAGAACTCCTCTTGCTTGGCC	0.557		NaN											0	0	0	0.000602	0	4	16									
ZNF439	90594	broad.mit.edu	37	19	11978815	11978815	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:11978815C>T	uc002mss.2	+	3	1059	c.931C>T	c.(931-933)CGT>TGT	p.R311C	ZNF439_uc002msr.2_Missense_Mutation_p.R175C	NM_152262	NP_689475	Q8NDP4	ZN439_HUMAN	zinc finger protein 439	311	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						CATGTGTCCCCGTTATGTTCG	0.413		NaN											0	0	0	0.008871	0	17	66									
CRLF1	9244	broad.mit.edu	37	19	18705144	18705144	+	Silent	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:18705144C>T	uc010ebt.1	-	7	1319	c.1125G>A	c.(1123-1125)AAG>AAA	p.K375K		NM_004750	NP_004741	O75462	CRLF1_HUMAN	cytokine receptor-like factor 1 precursor	375					negative regulation of neuron apoptosis|positive regulation of cell proliferation|positive regulation of tyrosine phosphorylation of Stat3 protein	extracellular space	cytokine binding|protein heterodimerization activity|receptor activity			central_nervous_system(1)	1						ACGCGTGCTTCTTGAGCCAGC	0.577		NaN											0	0	0	0.00308	0	8	22									
SF4	57794	broad.mit.edu	37	19	19407889	19407889	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:19407889C>G	uc002nmh.2	-	8	1154	c.1152G>C	c.(1150-1152)AAG>AAC	p.K384N	SF4_uc002nmf.2_5'UTR|SF4_uc002nmg.2_5'UTR|SF4_uc002nmi.2_Missense_Mutation_p.K174N|SF4_uc002nmj.2_Missense_Mutation_p.K174N|SF4_uc010xqr.1_RNA	NM_172231	NP_757386	Q8IWZ8	SUGP1_HUMAN	splicing factor 4	384	Nuclear localization signal (Potential).				nuclear mRNA splicing, via spliceosome	nucleoplasm|spliceosomal complex	RNA binding				0						CCCACCGGCTCTTCCGCTTCC	0.667		NaN											0	0	0	0.007413	0	17	27									
NPHS1	4868	broad.mit.edu	37	19	36322242	36322242	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:36322242C>T	uc002oby.2	-	26	3343	c.3343G>A	c.(3343-3345)GAG>AAG	p.E1115K	NPHS1_uc010eem.1_RNA	NM_004646	NP_004637	O60500	NPHN_HUMAN	nephrin precursor	1115	Cytoplasmic (Potential).				cell adhesion|excretion|muscle organ development	integral to plasma membrane				ovary(4)|skin(1)	5	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TGGCTCTCCTCATATTCGTTC	0.627		NaN											0	0	0	0.002445	0	32	52									
CATSPERG	57828	broad.mit.edu	37	19	38851428	38851428	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:38851428G>A	uc002oih.3	+	16	1912	c.1825G>A	c.(1825-1827)GAG>AAG	p.E609K	CATSPERG_uc002oig.3_Missense_Mutation_p.E569K|CATSPERG_uc002oif.3_Missense_Mutation_p.E249K|CATSPERG_uc010efw.2_RNA	NM_021185	NP_067008	Q6ZRH7	CTSRG_HUMAN	cation channel, sperm-associated, gamma	609	Extracellular (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(1)|skin(1)	2						CGTGCCCGTGGAGCAGCTTCT	0.577		NaN											0	0	0	0.001168	0	4	11									
RYR1	6261	broad.mit.edu	37	19	39071143	39071143	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:39071143C>T	uc002oit.2	+	101	14775	c.14645C>T	c.(14644-14646)ACG>ATG	p.T4882M	RYR1_uc002oiu.2_Missense_Mutation_p.T4877M	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	4882	Helical; Name=M9; (Potential).				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	GACATGATGACGGTGAGCCCC	0.313		NaN											0	0	0	0.002299	0	23	34									
DLL3	10683	broad.mit.edu	37	19	39995950	39995950	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:39995950G>C	uc002olx.2	+	6	1010	c.952G>C	c.(952-954)GAT>CAT	p.D318H	DLL3_uc010egq.2_Missense_Mutation_p.D318H|DLL3_uc002olw.2_Missense_Mutation_p.D318H	NM_016941	NP_058637	Q9NYJ7	DLL3_HUMAN	delta-like 3 protein isoform 1 precursor	318	EGF-like 3.|Extracellular (Potential).				Notch signaling pathway|skeletal system development	integral to membrane	Notch binding			central_nervous_system(2)|breast(1)	3	all_cancers(60;4.04e-06)|all_lung(34;1.77e-07)|Lung NSC(34;2.09e-07)|all_epithelial(25;1.13e-05)|Ovarian(47;0.159)		Epithelial(26;5.89e-26)|all cancers(26;1.96e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GACATGTGCAGATGGACCCTG	0.617		NaN											0	0	0	0.006999	0	35	61									
CYP2B6	1555	broad.mit.edu	37	19	41522600	41522600	+	Silent	SNP	C	C	A	rs138937514		TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:41522600C>A	uc002opr.1	+	9	1351	c.1344C>A	c.(1342-1344)CTC>CTA	p.L448L	CYP2A7_uc002opo.2_Intron|CYP2B6_uc010xvu.1_Silent_p.L248L	NM_000767	NP_000758	P20813	CP2B6_HUMAN	cytochrome P450, family 2, subfamily B,	448					cellular ketone metabolic process|exogenous drug catabolic process|steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(1)|skin(1)	2			LUSC - Lung squamous cell carcinoma(20;0.00322)		Bupropion(DB01156)|Butalbital(DB00241)|Carbamazepine(DB00564)|Clopidogrel(DB00758)|Cyclophosphamide(DB00531)|Efavirenz(DB00625)|Ifosfamide(DB01181)|Memantine(DB01043)|Meperidine(DB00454)|Mephenytoin(DB00532)|Methadone(DB00333)|Methylphenobarbital(DB00849)|Midazolam(DB00683)|Nelfinavir(DB00220)|Nevirapine(DB00238)|Nicotine(DB00184)|Orphenadrine(DB01173)|Phenytoin(DB00252)|Propofol(DB00818)|Ritonavir(DB00503)|Selegiline(DB01037)|Sertraline(DB01104)|Ticlopidine(DB00208)|Troleandomycin(DB01361)	AATTGTTCCTCTTCTTCACCA	0.572		NaN											1	0	4.68919e-08	0.008291	8.46595e-08	11	15									
CEACAM8	1088	broad.mit.edu	37	19	43097693	43097693	+	Missense_Mutation	SNP	G	G	A	rs146875157	byFrequency	TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:43097693G>A	uc002oud.2	-	2	526	c.424C>T	c.(424-426)CCG>TCG	p.P142S	uc010eif.1_Intron|uc010eig.1_Intron|uc010eih.1_Intron	NM_001816	NP_001807	P31997	CEAM8_HUMAN	carcinoembryonic antigen-related cell adhesion	142	Ig-like V-type.				immune response	anchored to membrane|extracellular space|integral to plasma membrane				ovary(1)	1		Prostate(69;0.00899)				AATCACTCACGATGTACGCTG	0.498		NaN											0	0	0	0.002096	0	33	64									
RTN2	6253	broad.mit.edu	37	19	45998201	45998201	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:45998201C>A	uc002pcb.2	-	3	370	c.142G>T	c.(142-144)GAG>TAG	p.E48*	RTN2_uc002pcc.2_Nonsense_Mutation_p.E48*|RTN2_uc002pcd.2_RNA	NM_005619	NP_005610	O75298	RTN2_HUMAN	reticulon 2 isoform A	48						integral to endoplasmic reticulum membrane	signal transducer activity			ovary(3)	3		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00829)|Epithelial(262;0.184)|GBM - Glioblastoma multiforme(486;0.246)		GTCTCCTCCTCGTCCTCCTCT	0.617		NaN											1	0	4.72057e-08	0.003954	8.50167e-08	25	31									
GPR4	2828	broad.mit.edu	37	19	46094676	46094676	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:46094676G>C	uc002pcm.2	-	2	1394	c.449C>G	c.(448-450)TCG>TGG	p.S150W	OPA3_uc010xxk.1_Intron	NM_005282	NP_005273	P46093	GPR4_HUMAN	G protein-coupled receptor 4	150	Helical; Name=4; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(262;0.0071)|GBM - Glioblastoma multiforme(486;0.128)|Epithelial(262;0.223)		CAGGGGCGCCGAGTTGGCGCC	0.667		NaN											0	0	0	0.00333	0	23	65									
IRF2BP1	26145	broad.mit.edu	37	19	46388452	46388452	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:46388452G>C	uc002pds.1	-	1	925	c.581C>G	c.(580-582)TCC>TGC	p.S194C		NM_015649	NP_056464	Q8IU81	I2BP1_HUMAN	interferon regulatory factor 2 binding protein	194					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0402)|Epithelial(262;0.231)		CTCGAAATCGGAGCCGAAGAG	0.647		NaN											0	0	0	0.002096	0	29	85									
PRRG2	5639	broad.mit.edu	37	19	50086939	50086939	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:50086939G>A	uc002pon.3	+	3	391	c.226G>A	c.(226-228)GAG>AAG	p.E76K	PRRG2_uc010yaz.1_Missense_Mutation_p.E53K	NM_000951	NP_000942	O14669	TMG2_HUMAN	proline rich Gla (G-carboxyglutamic acid) 2	76	Gla.|Extracellular (Potential).					extracellular region|integral to plasma membrane	calcium ion binding			skin(1)	1		all_lung(116;7.84e-06)|Lung NSC(112;2.8e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00295)|GBM - Glioblastoma multiforme(134;0.0121)		TTCCTGGGAAGAGGCCAGGGA	0.577		NaN											0	0	0	0.005443	0	26	60									
GPR32	2854	broad.mit.edu	37	19	51274256	51274256	+	Silent	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:51274256C>G	uc010ycf.1	+	1	399	c.399C>G	c.(397-399)GTC>GTG	p.V133V		NM_001506	NP_001497	O75388	GPR32_HUMAN	G protein-coupled receptor 32	133	Helical; Name=3; (Potential).					integral to plasma membrane	N-formyl peptide receptor activity			upper_aerodigestive_tract(1)	1		all_neural(266;0.131)		OV - Ovarian serous cystadenocarcinoma(262;0.00641)|GBM - Glioblastoma multiforme(134;0.028)		GCCTCCTTGTCTTCATCTCTG	0.577		NaN											0	0	0	0.003214	0	42	106									
KLK6	5653	broad.mit.edu	37	19	51470546	51470546	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:51470546C>T	uc002pui.2	-	4	336	c.76G>A	c.(76-78)GGA>AGA	p.G26R	KLK6_uc010eoj.2_Missense_Mutation_p.G26R|KLK6_uc002puh.2_Missense_Mutation_p.G35R|KLK6_uc002puj.2_5'UTR|KLK6_uc010ycn.1_Intron|KLK6_uc002pul.2_Missense_Mutation_p.G26R|KLK6_uc002pum.2_Intron	NM_001012964	NP_001012982	Q92876	KLK6_HUMAN	kallikrein-related peptidase 6 isoform A	26	Peptidase S1.				amyloid precursor protein metabolic process|central nervous system development|collagen catabolic process|hormone metabolic process|myelination|positive regulation of G-protein coupled receptor protein signaling pathway|protein autoprocessing|proteolysis|regulation of cell differentiation|tissue regeneration	endoplasmic reticulum|extracellular region|microsome|mitochondrion|nucleolus	protein binding|serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00372)|GBM - Glioblastoma multiforme(134;0.00871)		TCGCAGGGTCCGCCATGCACC	0.572		NaN											0	0	0	0.003271	0	34	16									
SIGLEC6	946	broad.mit.edu	37	19	52023405	52023405	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:52023405G>T	uc002pwy.2	-	8	1455	c.1293C>A	c.(1291-1293)TTC>TTA	p.F431L	SIGLEC6_uc002pwz.2_Missense_Mutation_p.F415L|SIGLEC6_uc002pxa.2_3'UTR|SIGLEC6_uc010ydb.1_Missense_Mutation_p.F368L|SIGLEC6_uc010ydc.1_3'UTR|SIGLEC6_uc010eoz.1_3'UTR	NM_001245	NP_001236	O43699	SIGL6_HUMAN	sialic acid binding Ig-like lectin 6 isoform 1	431	Cytoplasmic (Potential).				cell adhesion|cell-cell signaling	cytoplasm|extracellular region|integral to plasma membrane|membrane fraction|nucleus				ovary(1)	1		all_neural(266;0.0199)		GBM - Glioblastoma multiforme(134;0.00115)|OV - Ovarian serous cystadenocarcinoma(262;0.0165)		GCACCTTGTGGAAGTGTAGGA	0.502		NaN											1	0	9.84934e-19	0.002522	1.86071e-18	42	141									
ZNF175	7728	broad.mit.edu	37	19	52090205	52090205	+	Silent	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:52090205G>A	uc002pxb.2	+	5	999	c.621G>A	c.(619-621)CTG>CTA	p.L207L		NM_007147	NP_009078	Q9Y473	ZN175_HUMAN	zinc finger protein 175	207					response to virus	cytoplasm|intermediate filament cytoskeleton|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000426)|OV - Ovarian serous cystadenocarcinoma(262;0.0257)		GTTTGAAGCTGAACCTAGAAG	0.443		NaN											0	0	0	0.008871	0	18	61									
LILRA2	11027	broad.mit.edu	37	19	55086014	55086014	+	Nonsense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:55086014C>G	uc002qgg.3	+	3	406	c.317C>G	c.(316-318)TCA>TGA	p.S106*	LILRA2_uc010ern.2_Nonsense_Mutation_p.S106*|LILRA2_uc002qgf.2_Nonsense_Mutation_p.S106*|LILRA2_uc010yfe.1_Nonsense_Mutation_p.S106*|LILRA2_uc010yff.1_Nonsense_Mutation_p.S94*|LILRA2_uc010ero.2_Nonsense_Mutation_p.S94*|LILRA2_uc010yfg.1_Nonsense_Mutation_p.S106*	NM_001130917	NP_001124389	Q8N149	LIRA2_HUMAN	leukocyte immunoglobulin-like receptor,	106	Extracellular (Potential).|Ig-like C2-type 1.				defense response	integral to membrane	antigen binding|receptor activity			ovary(1)	1				GBM - Glioblastoma multiforme(193;0.0963)		AATCACTCATCAGAGTACAGT	0.592		NaN											0	0	0	0.00245	0	15	30									
PPP1R12C	54776	broad.mit.edu	37	19	55607503	55607503	+	Nonsense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr19:55607503G>A	uc002qix.2	-	8	1085	c.1069C>T	c.(1069-1071)CAG>TAG	p.Q357*	PPP1R12C_uc010yfs.1_Nonsense_Mutation_p.Q283*|PPP1R12C_uc002qiy.2_Nonsense_Mutation_p.Q357*	NM_017607	NP_060077	Q9BZL4	PP12C_HUMAN	protein phosphatase 1, regulatory subunit 12C	357						cytoplasm				ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.0449)		GACAAGTCCTGGAGGGAAATC	0.672		NaN											0	0	0	0.008871	0	19	40									
ADAM17	6868	broad.mit.edu	37	2	9642368	9642368	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:9642368C>T	uc002qzu.2	-	13	1765	c.1582G>A	c.(1582-1584)GAG>AAG	p.E528K	ADAM17_uc010ewy.2_Missense_Mutation_p.E528K|ADAM17_uc010ewz.2_Intron	NM_003183	NP_003174	P78536	ADA17_HUMAN	a disintegrin and metalloprotease domain 17	528	Disintegrin.|Extracellular (Potential).				B cell differentiation|cell adhesion mediated by integrin|epidermal growth factor receptor signaling pathway|epidermal growth factor receptor transactivation by G-protein coupled receptor signaling pathway|germinal center formation|membrane protein intracellular domain proteolysis|negative regulation of interleukin-8 production|nerve growth factor receptor signaling pathway|Notch signaling pathway|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell growth|positive regulation of cell proliferation|positive regulation of chemokine production|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of protein phosphorylation|positive regulation of T cell chemotaxis|positive regulation of transforming growth factor beta receptor signaling pathway|regulation of mast cell apoptosis|response to drug|response to high density lipoprotein particle stimulus|response to hypoxia|response to lipopolysaccharide|spleen development|T cell differentiation in thymus|wound healing, spreading of epidermal cells	actin cytoskeleton|apical plasma membrane|cell surface|cytoplasm|integral to plasma membrane|membrane raft	integrin binding|interleukin-6 receptor binding|metalloendopeptidase activity|PDZ domain binding|SH3 domain binding|zinc ion binding			lung(1)|kidney(1)	2	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)			Epithelial(75;0.225)		TGGGCAGTCTCAAACTGACAG	0.468		NaN											0	0	0	0.00361	0	57	123									
NOL10	79954	broad.mit.edu	37	2	10712233	10712233	+	Silent	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:10712233C>T	uc002raq.2	-	21	2156	c.2031G>A	c.(2029-2031)CTG>CTA	p.L677L	NOL10_uc010yje.1_Silent_p.L651L|NOL10_uc010yjf.1_Silent_p.L627L|NOL10_uc002rap.2_Silent_p.L627L	NM_024894	NP_079170	Q9BSC4	NOL10_HUMAN	nucleolar protein 10	677						nucleolus					0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.172)|OV - Ovarian serous cystadenocarcinoma(76;0.207)		GTCTTGACTTCAGGTGTCCGG	0.478		NaN											0	0	0	0.00361	0	88	203									
APOB	338	broad.mit.edu	37	2	21228217	21228217	+	Silent	SNP	A	A	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:21228217A>G	uc002red.2	-	26	11651	c.11523T>C	c.(11521-11523)AAT>AAC	p.N3841N		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	3841					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TGGCTACTGCATTTAGATCCA	0.458		NaN											0	0	0	0.003271	0	32	71									
CIB4	130106	broad.mit.edu	37	2	26806690	26806690	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:26806690C>A	uc002rhm.2	-	5	434	c.405G>T	c.(403-405)ATG>ATT	p.M135I		NM_001029881	NP_001025052	A0PJX0	CIB4_HUMAN	calcium and integrin binding family member 4	135							calcium ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGTCCTCAGACATGTCATCAC	0.567		NaN											1	0	7.41945e-09	0.005443	1.34283e-08	22	69									
DPYSL5	56896	broad.mit.edu	37	2	27162914	27162914	+	Silent	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:27162914C>T	uc002rhu.3	+	9	1121	c.963C>T	c.(961-963)ATC>ATT	p.I321I	DPYSL5_uc002rhv.3_Silent_p.I321I	NM_020134	NP_064519	Q9BPU6	DPYL5_HUMAN	dihydropyrimidinase-like 5	321					axon guidance|pyrimidine base catabolic process|signal transduction	cytosol	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides			ovary(2)	2	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CTCTGAACATCGTGGCATCAG	0.527		NaN											0	0	0	0.007835	0	36	87									
SLC30A6	55676	broad.mit.edu	37	2	32419022	32419022	+	Missense_Mutation	SNP	C	C	G	rs148435831		TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:32419022C>G	uc002roe.1	+	8	503	c.466C>G	c.(466-468)CGG>GGG	p.R156G	SLC30A6_uc002rof.1_Missense_Mutation_p.R196G|SLC30A6_uc010ymw.1_Missense_Mutation_p.R127G|SLC30A6_uc010ezr.1_Missense_Mutation_p.R156G|SLC30A6_uc002rog.1_5'UTR|SLC30A6_uc010ezs.1_Missense_Mutation_p.R82G|SLC30A6_uc002roh.1_5'UTR	NM_017964	NP_060434	Q6NXT4	ZNT6_HUMAN	solute carrier family 30 (zinc transporter),	156	Cytoplasmic (Potential).					Golgi membrane|integral to membrane	zinc ion transmembrane transporter activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.208)					GCTTTCTATTCGGAATAAACC	0.303		NaN											0	0	0	0.002836	0	29	87									
CEBPZ	10153	broad.mit.edu	37	2	37441016	37441016	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:37441016C>G	uc002rpz.2	-	10	2566	c.2536G>C	c.(2536-2538)GAG>CAG	p.E846Q		NM_005760	NP_005751	Q03701	CEBPZ_HUMAN	CCAAT/enhancer binding protein zeta	846					regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	nucleus	DNA binding			pancreas(1)	1		all_hematologic(82;0.21)				CCAATCAGCTCTTCAAATTCT	0.318		NaN											0	0	0	0.000978	0	12	16									
EPAS1	2034	broad.mit.edu	37	2	46583348	46583348	+	Silent	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:46583348G>A	uc002ruv.2	+	3	764	c.276G>A	c.(274-276)CTG>CTA	p.L92L		NM_001430	NP_001421	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	92	PAS 1.				angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			ovary(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			ACTTGTACCTGAAAGCCTTGG	0.517		NaN											0	0	0	0.00278	0	22	57									
EPAS1	2034	broad.mit.edu	37	2	46583934	46583934	+	Silent	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:46583934G>C	uc002ruv.2	+	4	929	c.441G>C	c.(439-441)CTG>CTC	p.L147L		NM_001430	NP_001421	Q99814	EPAS1_HUMAN	endothelial PAS domain protein 1	147	PAS 1.				angiogenesis|myoblast cell fate commitment|positive regulation of transcription from RNA polymerase II promoter|response to hypoxia	transcription factor complex	histone acetyltransferase binding|protein heterodimerization activity|sequence-specific enhancer binding RNA polymerase II transcription factor activity|signal transducer activity|transcription coactivator activity|transcription factor binding			ovary(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	LUSC - Lung squamous cell carcinoma(58;0.151)			GTGAGAACCTGAGTCTCAAAA	0.458		NaN											0	0	0	0.00499	0	16	33									
GPR75	10936	broad.mit.edu	37	2	54080793	54080793	+	Silent	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:54080793G>A	uc002rxo.3	-	2	1372	c.1101C>T	c.(1099-1101)TTC>TTT	p.F367F	ASB3_uc002rxi.3_Intron	NM_006794	NP_006785	O95800	GPR75_HUMAN	G protein-coupled receptor 75	367	Helical; Name=7; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			ovary(1)|skin(1)	2			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			ATCCTGACTTGAAAAATATAA	0.428		NaN											0	0	0	0.001855	0	14	57									
EHBP1	23301	broad.mit.edu	37	2	63175857	63175857	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:63175857G>A	uc002sby.2	+	14	2463	c.1981G>A	c.(1981-1983)GGA>AGA	p.G661R	EHBP1_uc010fcp.2_Missense_Mutation_p.G626R|EHBP1_uc002sbz.2_Missense_Mutation_p.G626R|EHBP1_uc002scb.2_Missense_Mutation_p.G626R	NM_015252	NP_056067	Q8NDI1	EHBP1_HUMAN	EH domain binding protein 1 isoform 1	661						cytoplasm|membrane				ovary(1)|breast(1)	2	Lung NSC(7;0.0951)|all_lung(7;0.169)		LUSC - Lung squamous cell carcinoma(7;7.74e-05)|Epithelial(17;0.189)			GCAGAGCTCTGGAAGGACTTC	0.468		NaN							Hereditary_Prostate_Cancer				0	0	0	0.004007	0	17	24									
SFTPB	6439	broad.mit.edu	37	2	85890579	85890579	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:85890579C>T	uc002sqh.2	-	8	898	c.892G>A	c.(892-894)GAG>AAG	p.E298K	SFTPB_uc002sqi.2_Missense_Mutation_p.E306K|SFTPB_uc002sqj.2_Missense_Mutation_p.E298K|SFTPB_uc010ysw.1_5'Flank	NM_198843	NP_942140	P07988	PSPB_HUMAN	surfactant, pulmonary-associated protein B	298	Saposin B-type 3.				organ morphogenesis|respiratory gaseous exchange|sphingolipid metabolic process	extracellular space|lysosome				ovary(1)|central_nervous_system(1)	2						AGGTGGCACTCAGAGTCTCGC	0.612		NaN											0	0	0	0.004007	0	14	28									
AFF3	3899	broad.mit.edu	37	2	100170988	100170988	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:100170988C>T	uc002tag.2	-	23	3580	c.3344G>A	c.(3343-3345)GGA>GAA	p.G1115E	AFF3_uc002taf.2_Missense_Mutation_p.G1140E	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	1115					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						GGATGGGGTTCCAGTGCTCCT	0.652		NaN											0	0	0	0.000248	0	4	7									
CCDC138	165055	broad.mit.edu	37	2	109411023	109411023	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:109411023C>G	uc002ten.1	+	5	482	c.422C>G	c.(421-423)TCG>TGG	p.S141W	CCDC138_uc002teo.1_Missense_Mutation_p.S141W|CCDC138_uc002tep.1_Translation_Start_Site|CCDC138_uc010fjm.1_Translation_Start_Site	NM_144978	NP_659415	Q96M89	CC138_HUMAN	coiled-coil domain containing 138	141											0						ACGACCTCATCGAGACCTCGG	0.383		NaN											0	0	0	0.004289	0	32	58									
MERTK	10461	broad.mit.edu	37	2	112705072	112705072	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:112705072A>G	uc002thk.1	+	4	807	c.685A>G	c.(685-687)ATT>GTT	p.I229V	MERTK_uc002thl.1_Missense_Mutation_p.I53V	NM_006343	NP_006334	Q12866	MERTK_HUMAN	MER receptor tyrosine kinase precursor	229	Extracellular (Potential).|Ig-like C2-type 2.				cell surface receptor linked signaling pathway|cell-cell signaling|leukocyte migration	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|upper_aerodigestive_tract(1)|stomach(1)|kidney(1)	9						GCCCGTCAACATTTTCTGGGT	0.507		NaN											0	0	0	0.007413	0	19	56									
IWS1	55677	broad.mit.edu	37	2	128255777	128255777	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:128255777C>A	uc002ton.2	-	6	1807	c.1504G>T	c.(1504-1506)GAA>TAA	p.E502*	IWS1_uc010yzl.1_Intron	NM_017969	NP_060439	Q96ST2	IWS1_HUMAN	IWS1 homolog	502	Glu-rich.				transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.0735)		ACCTGTGTTTCACCTTTTTCT	0.299		NaN											1	0	2.39556e-15	0.00278	4.50243e-15	23	61									
SCN9A	6335	broad.mit.edu	37	2	167168028	167168028	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:167168028G>A	uc010fpl.2	-	2	580	c.239C>T	c.(238-240)CCC>CTC	p.P80L		NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	80						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	TGCATAGTAGGGGTCCAAGTC	0.448		NaN											0	0	0	0.005524	0	38	28									
TTN	7273	broad.mit.edu	37	2	179431057	179431057	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:179431057C>A	uc010zfg.1	-	275	72322	c.72098G>T	c.(72097-72099)GGA>GTA	p.G24033V	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.G17728V|TTN_uc010zfi.1_Missense_Mutation_p.G17661V|TTN_uc010zfj.1_Missense_Mutation_p.G17536V	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	24960							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TACAACAATTCCTTTTCTTAA	0.438		NaN											1	0	2.73381e-35	0.00361	5.25953e-35	55	127									
TTN	7273	broad.mit.edu	37	2	179622543	179622543	+	Silent	SNP	G	G	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:179622543G>T	uc010zfi.1	-	44	10490	c.10266C>A	c.(10264-10266)ATC>ATA	p.I3422I	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron|TTN_uc002unb.2_Intron	NM_133432	NP_597676	Q8WZ42	TITIN_HUMAN	titin isoform novex-1	3506							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACAGAGGCTGGATGAAGCTGG	0.458		NaN											1	0	1.21457e-23	0.00361	2.30643e-23	86	62									
DNAH7	56171	broad.mit.edu	37	2	196698996	196698996	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:196698996C>A	uc002utj.3	-	48	9135	c.9034G>T	c.(9034-9036)GTG>TTG	p.V3012L		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	3012	AAA 5 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						AGTTTAATCACATAAAGACTA	0.383		NaN											1	0	3.11337e-16	0.002836	5.86659e-16	35	14									
ABCA12	26154	broad.mit.edu	37	2	215875186	215875186	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:215875186A>G	uc002vew.2	-	18	2561	c.2341T>C	c.(2341-2343)TGC>CGC	p.C781R	ABCA12_uc002vev.2_Missense_Mutation_p.C463R|ABCA12_uc010zjn.1_5'UTR	NM_173076	NP_775099	Q86UK0	ABCAC_HUMAN	ATP-binding cassette, sub-family A, member 12	781					cellular homeostasis|lipid transport	integral to membrane	ATP binding|ATPase activity			ovary(6)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	11		Renal(323;0.127)		Epithelial(149;1.01e-05)|all cancers(144;0.00112)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.011)		AGGGAGAAGCAAAATGGTGCT	0.368		NaN											0	0	0	0.00245	0	14	11									
HDLBP	3069	broad.mit.edu	37	2	242186257	242186257	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:242186257C>G	uc002waz.2	-	16	2088	c.1860G>C	c.(1858-1860)GAG>GAC	p.E620D	HDLBP_uc002wba.2_Missense_Mutation_p.E620D|HDLBP_uc002wbb.2_Missense_Mutation_p.E572D	NM_203346	NP_976221	Q00341	VIGLN_HUMAN	high density lipoprotein binding protein	620	KH 7.				cholesterol metabolic process|lipid transport	cytoplasm|high-density lipoprotein particle|nucleus|plasma membrane	lipid binding|protein binding|RNA binding			breast(3)|skin(1)	4		all_cancers(19;7.77e-41)|all_epithelial(40;1.74e-18)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00338)|Ovarian(221;0.00556)|Lung NSC(271;0.0121)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;8.13e-34)|all cancers(36;4.71e-31)|OV - Ovarian serous cystadenocarcinoma(60;2.34e-15)|Kidney(56;3.72e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.76e-08)|BRCA - Breast invasive adenocarcinoma(100;3.38e-06)|Lung(119;0.000109)|LUSC - Lung squamous cell carcinoma(224;0.000964)|Colorectal(34;0.0132)|COAD - Colon adenocarcinoma(134;0.0928)		AATTGCTATTCTCTGCTGGAA	0.488		NaN											0	0	0	0.00361	0	61	144									
TGM6	343641	broad.mit.edu	37	20	2377244	2377244	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr20:2377244C>T	uc002wfy.1	+	4	578	c.517C>T	c.(517-519)CGA>TGA	p.R173*	TGM6_uc010gal.1_Nonsense_Mutation_p.R173*	NM_198994	NP_945345	O95932	TGM3L_HUMAN	transglutaminase 6	173					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(3)|skin(1)	4					L-Glutamine(DB00130)	GAAGCACATACGAGCCCAGGG	0.612		NaN											0	0	0	0.001984	0	7	39									
CDS2	8760	broad.mit.edu	37	20	5170443	5170443	+	Silent	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr20:5170443G>C	uc002wls.2	+	12	1421	c.1164G>C	c.(1162-1164)CTG>CTC	p.L388L	CDS2_uc010zqt.1_RNA|CDS2_uc002wlu.2_Nonstop_Mutation_p.*340S|CDS2_uc010zqu.1_Silent_p.L268L|CDS2_uc002wlv.2_Silent_p.L290L|CDS2_uc010zqv.1_Silent_p.L158L	NM_003818	NP_003809	O95674	CDS2_HUMAN	phosphatidate cytidylyltransferase 2	388					phospholipid biosynthetic process	integral to membrane|mitochondrial inner membrane	phosphatidate cytidylyltransferase activity				0						GCCAGTATCTGATGGCCACCT	0.468		NaN											0	0	0	0.003214	0	45	157									
HAO1	54363	broad.mit.edu	37	20	7866353	7866353	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr20:7866353C>G	uc002wmw.1	-	6	996	c.972G>C	c.(970-972)CAG>CAC	p.Q324H	HAO1_uc010gbu.2_Missense_Mutation_p.Q324H	NM_017545	NP_060015	Q9UJM8	HAOX1_HUMAN	hydroxyacid oxidase 1	324	FMN hydroxy acid dehydrogenase.				cellular nitrogen compound metabolic process|fatty acid alpha-oxidation|glycolate catabolic process|glyoxylate metabolic process	peroxisomal matrix	FMN binding|glycolate oxidase activity|glyoxylate oxidase activity			ovary(3)	3						GTCCAGTTACCTGGAAAGCTA	0.428		NaN											0	0	0	0.00361	0	77	98									
PAK7	57144	broad.mit.edu	37	20	9561234	9561234	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr20:9561234G>C	uc002wnl.2	-	5	1093	c.548C>G	c.(547-549)TCT>TGT	p.S183C	PAK7_uc002wnk.2_Missense_Mutation_p.S183C|PAK7_uc002wnj.2_Missense_Mutation_p.S183C|PAK7_uc010gby.1_Missense_Mutation_p.S183C	NM_020341	NP_065074	Q9P286	PAK7_HUMAN	p21-activated kinase 7	183	Linker.						ATP binding|protein binding|protein serine/threonine kinase activity			lung(11)|skin(5)|central_nervous_system(3)|ovary(2)|large_intestine(1)|stomach(1)	23			COAD - Colon adenocarcinoma(9;0.194)			CTTCACCTCAGAATAGTAGGC	0.458		NaN											0	0	0	0.00361	0	70	102									
FLRT3	23767	broad.mit.edu	37	20	14307438	14307438	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr20:14307438C>T	uc002wov.1	-	3	1182	c.715G>A	c.(715-717)GCT>ACT	p.A239T	MACROD2_uc002wot.2_Intron|MACROD2_uc002wou.2_Intron|FLRT3_uc002wow.1_Missense_Mutation_p.A239T	NM_198391	NP_938205	Q9NZU0	FLRT3_HUMAN	fibronectin leucine rich transmembrane protein 3	239	Extracellular (Potential).|LRR 8.				cell adhesion	integral to plasma membrane|proteinaceous extracellular matrix	protein binding, bridging|receptor signaling protein activity			kidney(1)	1		Colorectal(1;0.0464)	COAD - Colon adenocarcinoma(2;0.129)	Colorectal(1;0.0393)		ACTGGTGCAGCAGTCAGGGAA	0.438		NaN											0	0	0	0.007413	0	18	36									
PLAGL2	5326	broad.mit.edu	37	20	30784504	30784504	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr20:30784504G>T	uc002wxn.2	-	3	1459	c.1242C>A	c.(1240-1242)TTC>TTA	p.F414L		NM_002657	NP_002648	Q9UPG8	PLAL2_HUMAN	pleiomorphic adenoma gene-like 2	414						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			GTAGGTGGGAGAAGTCCACAT	0.642		NaN											1	0	0.000151284	0.001855	0.0002634	14	16									
NCOA6	23054	broad.mit.edu	37	20	33345756	33345756	+	Silent	SNP	T	T	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr20:33345756T>C	uc002xav.2	-	8	3366	c.795A>G	c.(793-795)CAA>CAG	p.Q265Q	NCOA6_uc002xaw.2_Silent_p.Q265Q|NCOA6_uc010gew.1_Silent_p.Q222Q	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	265	TBP/GTF2A-binding region.|NCOA1-binding region.|Gln-rich.|CREBBP-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						gttgttgttgttgctgctgct	0.313		NaN											0	0	0	0.000602	0	4	63									
KCNQ2	3785	broad.mit.edu	37	20	62065242	62065242	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr20:62065242G>C	uc002yey.1	-	8	1215	c.1038C>G	c.(1036-1038)TTC>TTG	p.F346L	KCNQ2_uc002yez.1_Missense_Mutation_p.F346L|KCNQ2_uc002yfa.1_Missense_Mutation_p.F346L|KCNQ2_uc002yfb.1_Missense_Mutation_p.F346L|KCNQ2_uc011aax.1_Missense_Mutation_p.F346L|KCNQ2_uc002yfc.1_Missense_Mutation_p.F346L	NM_172107	NP_742105	O43526	KCNQ2_HUMAN	potassium voltage-gated channel KQT-like protein	346	Cytoplasmic (Potential).				axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)|ovary(1)	2	all_cancers(38;1.24e-11)		BRCA - Breast invasive adenocarcinoma(10;1.04e-05)		Amitriptyline(DB00321)	TGGTGGCGTAGAATCTCCAGG	0.692		NaN											0	0	0	0.006214	0	10	51									
IFNAR1	3454	broad.mit.edu	37	21	34721714	34721714	+	Silent	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr21:34721714C>G	uc002yrn.2	+	8	1155	c.1008C>G	c.(1006-1008)GTC>GTG	p.V336V	IFNAR1_uc011adv.1_Silent_p.V267V	NM_000629	NP_000620	P17181	INAR1_HUMAN	interferon-alpha receptor 1 precursor	336	Fibronectin type-III 3.|Extracellular (Potential).				JAK-STAT cascade|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	integral to plasma membrane	type I interferon receptor activity			central_nervous_system(1)|skin(1)	2					Interferon Alfa-2a, Recombinant(DB00034)|Interferon Alfa-2b, Recombinant(DB00105)|Interferon alfa-n1(DB00011)|Interferon alfa-n3(DB00018)|Interferon alfacon-1(DB00069)|Interferon beta-1b(DB00068)|Peginterferon alfa-2a(DB00008)|Peginterferon alfa-2b(DB00022)	TTCCTCCAGTCTTTAACATTA	0.343		NaN											0	0	0	0.000978	0	12	20									
ITSN1	6453	broad.mit.edu	37	21	35144562	35144562	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr21:35144562G>C	uc002yta.1	+	12	1508	c.1240G>C	c.(1240-1242)GAA>CAA	p.E414Q	DONSON_uc002ysn.1_Intron|ITSN1_uc002yth.3_RNA|ITSN1_uc002ysz.2_Missense_Mutation_p.E414Q|ITSN1_uc010gmg.2_Missense_Mutation_p.E377Q|ITSN1_uc010gmh.2_RNA|ITSN1_uc002ysw.2_Missense_Mutation_p.E414Q|ITSN1_uc010gmi.2_Missense_Mutation_p.E377Q|ITSN1_uc010gmj.2_Missense_Mutation_p.E298Q|ITSN1_uc002ysy.2_Missense_Mutation_p.E414Q|ITSN1_uc002ysx.2_Missense_Mutation_p.E377Q|ITSN1_uc002ytb.1_Missense_Mutation_p.E414Q|ITSN1_uc002ytc.1_Missense_Mutation_p.E414Q|ITSN1_uc002ytd.2_RNA|ITSN1_uc010gmk.2_Missense_Mutation_p.E377Q|ITSN1_uc010gml.2_RNA|ITSN1_uc002ytj.2_Missense_Mutation_p.E414Q|ITSN1_uc010gmm.1_RNA|ITSN1_uc002yte.2_Missense_Mutation_p.E348Q	NM_003024	NP_003015	Q15811	ITSN1_HUMAN	intersectin 1 isoform ITSN-l	414	Potential.|KLERQ.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|synaptic vesicle endocytosis	cell junction|coated pit|cytosol|lamellipodium|synapse|synaptosome	calcium ion binding|proline-rich region binding|protein complex scaffold|Rho guanyl-nucleotide exchange factor activity			ovary(3)|skin(1)	4						gaagcaactggaaaagcagcg	0.383		NaN											0	0	0	0.001168	0	6	1									
PFKL	5211	broad.mit.edu	37	21	45726580	45726580	+	Silent	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr21:45726580C>G	uc002zel.2	+	2	161	c.102C>G	c.(100-102)GTC>GTG	p.V34V	PFKL_uc002zek.2_Silent_p.V81V|PFKL_uc011afd.1_Silent_p.V81V	NM_002626	NP_002617	P17858	K6PL_HUMAN	liver phosphofructokinase	34					fructose 6-phosphate metabolic process|glycolysis|protein oligomerization	6-phosphofructokinase complex	6-phosphofructokinase activity|ATP binding|fructose-6-phosphate binding|identical protein binding|kinase binding|metal ion binding				0				Colorectal(79;0.0811)		ACGCTGCTGTCCGGGCTGTGA	0.602		NaN											0	0	0	0.00308	0	7	8									
GNB1L	54584	broad.mit.edu	37	22	19799811	19799811	+	Silent	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr22:19799811G>A	uc002zqe.1	-	4	808	c.414C>T	c.(412-414)GAC>GAT	p.D138D	GNB1L_uc002zqd.1_Translation_Start_Site|GNB1L_uc002zqf.1_Silent_p.D138D	NM_053004	NP_443730	Q9BYB4	GNB1L_HUMAN	guanine nucleotide binding protein	138					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	internal side of plasma membrane|intracellular				breast(1)	1	Colorectal(54;0.0993)					CTCTCACCTCGTCGCTGCCCC	0.647		NaN											0	0	0	0.001368	0	10	15									
PPM1F	9647	broad.mit.edu	37	22	22280017	22280017	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr22:22280017C>T	uc002zvp.1	-	7	1024	c.910G>A	c.(910-912)GAA>AAA	p.E304K	PPM1F_uc011aik.1_Missense_Mutation_p.E200K|PPM1F_uc002zvq.2_Missense_Mutation_p.E304K	NM_014634	NP_055449	P49593	PPM1F_HUMAN	protein phosphatase 1F	304					apoptosis|protein dephosphorylation	protein serine/threonine phosphatase complex	metal ion binding|protein serine/threonine phosphatase activity			ovary(2)|large_intestine(1)|breast(1)|kidney(1)	5	Colorectal(54;0.105)			READ - Rectum adenocarcinoma(21;0.155)		CCCAATGCTTCAATGCGCGCC	0.622		NaN											0	0	0	0.00499	0	14	22									
GAS2L1	10634	broad.mit.edu	37	22	29708459	29708459	+	Silent	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr22:29708459G>A	uc003afa.1	+	7	2218	c.2019G>A	c.(2017-2019)CCG>CCA	p.P673P	GAS2L1_uc010gvm.1_Silent_p.P446P|GAS2L1_uc003afb.1_3'UTR|GAS2L1_uc003afc.1_Silent_p.P673P|GAS2L1_uc003afd.1_3'UTR|GAS2L1_uc003afe.1_3'UTR	NM_152236	NP_689422	Q99501	GA2L1_HUMAN	growth arrest-specific 2 like 1 isoform a	673					cell cycle arrest	cytoplasm|cytoskeleton					0						CAGTCACCCCGAGGGCTGAGC	0.637		NaN											0	0	0	0.000602	0	5	18									
EIF4ENIF1	56478	broad.mit.edu	37	22	31838041	31838041	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr22:31838041G>T	uc003akz.1	-	17	2434	c.2270C>A	c.(2269-2271)TCC>TAC	p.S757Y	EIF4ENIF1_uc003akx.1_Missense_Mutation_p.S412Y|EIF4ENIF1_uc003aky.1_Missense_Mutation_p.S437Y|EIF4ENIF1_uc003ala.1_Missense_Mutation_p.S757Y|EIF4ENIF1_uc003alb.1_Missense_Mutation_p.S583Y|EIF4ENIF1_uc003akw.1_Missense_Mutation_p.S247Y	NM_019843	NP_062817	Q9NRA8	4ET_HUMAN	eukaryotic translation initiation factor 4E	757						nucleus	protein binding|protein transporter activity			ovary(1)	1						TGACAGTTTGGAATTTGTAGT	0.468		NaN											1	0	5.48756e-27	0.002852	1.05298e-26	42	113									
FOXRED2	80020	broad.mit.edu	37	22	36892254	36892254	+	Missense_Mutation	SNP	T	T	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr22:36892254T>G	uc003apn.3	-	6	1492	c.1384A>C	c.(1384-1386)AAT>CAT	p.N462H	FOXRED2_uc003apm.3_Missense_Mutation_p.N14H|FOXRED2_uc003apo.3_Missense_Mutation_p.N462H|FOXRED2_uc003app.3_Missense_Mutation_p.N462H	NM_024955	NP_079231	Q8IWF2	FXRD2_HUMAN	FAD-dependent oxidoreductase domain containing 2	462					ER-associated protein catabolic process	endoplasmic reticulum lumen	flavin adenine dinucleotide binding|oxidoreductase activity|protein binding			lung(1)|kidney(1)	2						GCCGTGGAATTCCTGGGAGAA	0.617		NaN											0	0	0	0.00245	0	14	49									
EP300	2033	broad.mit.edu	37	22	41545045	41545045	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08			A	G	A	A		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr22:41545045A>G	uc003azl.3	+	13	2640	c.2245A>G	c.(2245-2247)ATG>GTG	p.M749V		NM_001429	NP_001420	Q09472	EP300_HUMAN	E1A binding protein p300	749					apoptosis|cell cycle|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|histone H4 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of androgen receptor signaling pathway|response to estrogen stimulus|response to hypoxia	centrosome|histone acetyltransferase complex	androgen receptor binding|beta-catenin binding|DNA binding|histone acetyltransferase activity|RNA polymerase II activating transcription factor binding|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(22)|large_intestine(13)|breast(9)|central_nervous_system(5)|upper_aerodigestive_tract(4)|pancreas(4)|lung(3)|ovary(2)|stomach(1)|skin(1)	64						TTTTCAGCCTATGGGCTATGG	0.393		NaN	T| N|F|Mis|O	MLL|RUNXBP2	colorectal|breast|pancreatic|AML|ALL|DLBCL				Rubinstein-Taybi_syndrome				0	0	0	0.003163	0	15	34									
CCDC134	79879	broad.mit.edu	37	22	42209302	42209302	+	Silent	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr22:42209302C>T	uc003bbh.1	+	5	454	c.345C>T	c.(343-345)TTC>TTT	p.F115F	WBP2NL_uc011ape.1_Intron|LOC339674_uc003bba.1_Intron|CCDC134_uc011apg.1_Intron	NM_024821	NP_079097	Q9H6E4	CC134_HUMAN	coiled-coil domain containing 134 precursor	115						extracellular region				ovary(2)	2						CGGCCTTCTTCGGCGATGTGG	0.592		NaN											0	0	0	0.002445	0	28	83									
CCR3	1232	broad.mit.edu	37	3	46306696	46306696	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr3:46306696A>G	uc003cpg.1	+	4	590	c.47A>G	c.(46-48)TAC>TGC	p.Y16C	CCR3_uc003cpi.1_Missense_Mutation_p.Y16C|CCR3_uc003cpj.1_Missense_Mutation_p.Y16C|CCR3_uc003cpk.1_Missense_Mutation_p.Y37C|CCR3_uc010hjb.1_Missense_Mutation_p.Y34C|CCR3_uc003cpl.1_Missense_Mutation_p.Y49C	NM_178329	NP_847899	P51677	CCR3_HUMAN	CC chemokine receptor 3 isoform 1	16	Extracellular (Potential).				cell adhesion|cellular defense response|chemotaxis|elevation of cytosolic calcium ion concentration|G-protein signaling, coupled to cAMP nucleotide second messenger|inflammatory response|interspecies interaction between organisms|positive regulation of angiogenesis	integral to plasma membrane				ovary(3)|lung(3)|breast(1)|kidney(1)	8				BRCA - Breast invasive adenocarcinoma(193;0.00119)|KIRC - Kidney renal clear cell carcinoma(197;0.0183)|Kidney(197;0.0216)		ACCACATCCTACTATGATGAC	0.478		NaN											0	0	0	0.002299	0	19	21									
CCR5	1234	broad.mit.edu	37	3	46414985	46414985	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr3:46414985A>G	uc003cpo.3	+	3	714	c.592A>G	c.(592-594)ATA>GTA	p.I198V	CCR5_uc010hjd.2_Missense_Mutation_p.I198V	NM_001100168	NP_001093638	P51681	CCR5_HUMAN	chemokine (C-C motif) receptor 5	198	Extracellular (Potential).				cell-cell signaling|cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|entry into host cell|immune response|inflammatory response|initiation of viral infection	endosome|external side of plasma membrane|integral to plasma membrane	actin binding|C-C chemokine receptor activity|coreceptor activity|phosphatidylinositol phospholipase C activity			lung(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)	6				BRCA - Breast invasive adenocarcinoma(193;0.00112)|KIRC - Kidney renal clear cell carcinoma(197;0.017)|Kidney(197;0.02)	Maraviroc(DB04835)	GACATTAAAGATAGTCATCTT	0.438		NaN											0	0	0	0.00361	0	110	127									
FLNB	2317	broad.mit.edu	37	3	58120443	58120443	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr3:58120443G>T	uc003djj.2	+	27	4780	c.4615G>T	c.(4615-4617)GAC>TAC	p.D1539Y	FLNB_uc010hne.2_Missense_Mutation_p.D1570Y|FLNB_uc003djk.2_Missense_Mutation_p.D1539Y|FLNB_uc010hnf.2_Missense_Mutation_p.D1539Y|FLNB_uc003djl.2_Missense_Mutation_p.D1370Y|FLNB_uc003djm.2_Missense_Mutation_p.D1370Y	NM_001457	NP_001448	O75369	FLNB_HUMAN	filamin B isoform 2	1539	Filamin 14.				actin cytoskeleton organization|cell differentiation|cytoskeletal anchoring at plasma membrane|signal transduction	cell cortex|integral to membrane|nucleus|sarcomere	actin binding			breast(8)|ovary(5)|lung(3)|skin(2)|central_nervous_system(1)	19				BRCA - Breast invasive adenocarcinoma(55;0.000335)|KIRC - Kidney renal clear cell carcinoma(284;0.0726)|Kidney(284;0.0898)		TCTACCTGTGGACTTTGCAAT	0.507		NaN											1	0	4.17463e-26	0.00361	7.98956e-26	52	70									
IQCB1	9657	broad.mit.edu	37	3	121507259	121507259	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr3:121507259G>A	uc010hre.1	-	12	1365	c.1150C>T	c.(1150-1152)CGG>TGG	p.R384W	IQCB1_uc003eek.2_Missense_Mutation_p.R251W|IQCB1_uc010hrf.1_RNA	NM_001023570	NP_001018864	Q15051	IQCB1_HUMAN	IQ motif containing B1 isoform a	384					cilium assembly|maintenance of organ identity|photoreceptor cell maintenance	centrosome|photoreceptor connecting cilium	calmodulin binding				0				GBM - Glioblastoma multiforme(114;0.0983)		TCCATTTCCCGATAGTGTTTC	0.388		NaN											0	0	0	0.00361	0	50	211									
SEMA5B	54437	broad.mit.edu	37	3	122646791	122646791	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr3:122646791G>C	uc003efz.1	-	8	1000	c.696C>G	c.(694-696)GAC>GAG	p.D232E	SEMA5B_uc011bju.1_Missense_Mutation_p.D174E|SEMA5B_uc003ega.1_RNA|SEMA5B_uc003egb.1_Missense_Mutation_p.D232E|SEMA5B_uc010hro.1_Missense_Mutation_p.D174E|SEMA5B_uc010hrp.1_RNA	NM_001031702	NP_001026872	Q9P283	SEM5B_HUMAN	semaphorin 5B isoform 1	232	Extracellular (Potential).|Sema.				cell differentiation|nervous system development	integral to membrane	receptor activity			ovary(2)|breast(2)|pancreas(2)|central_nervous_system(1)	7				GBM - Glioblastoma multiforme(114;0.0367)		TGTGGCGTGGGTCATAGGGGC	0.612		NaN											0	0	0	0.001855	0	13	87									
DNAJC13	23317	broad.mit.edu	37	3	132185188	132185188	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr3:132185188G>C	uc003eor.2	+	19	2079	c.2014G>C	c.(2014-2016)GAG>CAG	p.E672Q	DNAJC13_uc010htq.1_Missense_Mutation_p.E672Q	NM_015268	NP_056083	O75165	DJC13_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 13	672							heat shock protein binding			ovary(1)|breast(1)	2						TCTCGTACCTGAGAAGGATGC	0.393		NaN											0	0	0	0.007413	0	17	63									
XRN1	54464	broad.mit.edu	37	3	142151723	142151723	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr3:142151723C>G	uc003eus.2	-	2	155	c.88G>C	c.(88-90)GAC>CAC	p.D30H	XRN1_uc003eut.2_Missense_Mutation_p.D30H|XRN1_uc003euu.2_Missense_Mutation_p.D30H|XRN1_uc003euw.2_Missense_Mutation_p.D30H|XRN1_uc011bnh.1_5'UTR	NM_019001	NP_061874	Q8IZH2	XRN1_HUMAN	5'-3' exoribonuclease 1 isoform a	30					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear mRNA surveillance|rRNA catabolic process	cytosol|Golgi apparatus|intermediate filament cytoskeleton|plasma membrane	5'-3' exonuclease activity|DNA binding|protein binding|RNA binding			ovary(3)	3						TACAAGTTGTCAAATTCAGGA	0.308		NaN											0	0	0	0.006214	0	10	45									
GFM1	85476	broad.mit.edu	37	3	158363446	158363446	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr3:158363446C>T	uc003fce.2	+	2	217	c.110C>T	c.(109-111)TCA>TTA	p.S37L	GFM1_uc003fcd.2_Missense_Mutation_p.S37L|GFM1_uc003fcf.2_RNA|GFM1_uc003fcg.2_5'Flank	NM_024996	NP_079272	Q96RP9	EFGM_HUMAN	G elongation factor, mitochondrial 1 precursor	37					mitochondrial translational elongation	mitochondrion	GTP binding|GTPase activity|translation elongation factor activity			ovary(3)|central_nervous_system(1)	4			Lung(72;0.00309)|LUSC - Lung squamous cell carcinoma(72;0.0043)			CGATGGTCTTCATCAGGGGTG	0.368		NaN											0	0	0	0.002299	0	22	65									
SLC7A14	57709	broad.mit.edu	37	3	170216488	170216488	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr3:170216488C>T	uc003fgz.2	-	4	1043	c.727G>A	c.(727-729)GAG>AAG	p.E243K	CLDN11_uc011bpt.1_Intron|uc003fha.1_Intron	NM_020949	NP_066000	Q8TBB6	S7A14_HUMAN	solute carrier family 7 (cationic amino acid	243						integral to membrane	amino acid transmembrane transporter activity			ovary(2)|upper_aerodigestive_tract(1)|liver(1)|central_nervous_system(1)	5	all_cancers(22;2.41e-22)|all_epithelial(15;4.2e-27)|all_lung(20;1.17e-16)|Lung NSC(18;4.91e-16)|Ovarian(172;0.000902)|Breast(254;0.137)		Lung(28;6.23e-13)|LUSC - Lung squamous cell carcinoma(14;1.48e-12)			AACTGGCCCTCCGCCCAGTAT	0.517		NaN											0	0	0	0.003163	0	15	44									
PIK3CA	5290	broad.mit.edu	37	3	178928074	178928074	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08			G	T	G	G		Valid	Somatic	Phase_I	WXS	Fluidigm;RNASeq			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr3:178928074G>T	uc003fjk.2	+	8	1509	c.1352G>T	c.(1351-1353)GGA>GTA	p.G451V		NM_006218	NP_006209	P42336	PK3CA_HUMAN	phosphoinositide-3-kinase, catalytic, alpha	451	C2 PI3K-type.				epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.G451_L456>V(1)|p.P449_L455del(1)		breast(1564)|large_intestine(776)|endometrium(246)|urinary_tract(195)|ovary(141)|skin(112)|stomach(98)|thyroid(77)|central_nervous_system(69)|lung(65)|upper_aerodigestive_tract(58)|haematopoietic_and_lymphoid_tissue(27)|cervix(25)|biliary_tract(22)|liver(20)|oesophagus(17)|pancreas(11)|penis(8)|pituitary(8)|autonomic_ganglia(4)|prostate(3)|kidney(2)|meninges(1)|eye(1)|NS(1)|soft_tissue(1)|bone(1)	3553	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			GTACCTCATGGATTAGAAGAT	0.348		57	Mis		colorectal|gastric|gliobastoma|breast					HNSCC(19;0.045)|TSP Lung(28;0.18)			1	0	9.65021e-13	0.002096	1.78626e-12	30	102									
ECE2	9718	broad.mit.edu	37	3	184001650	184001650	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr3:184001650G>C	uc003fni.3	+	8	1286	c.1248G>C	c.(1246-1248)CAG>CAC	p.Q416H	ECE2_uc011brh.1_Missense_Mutation_p.Q269H|ECE2_uc003fnl.3_Missense_Mutation_p.Q344H|ECE2_uc003fnm.3_Missense_Mutation_p.Q298H|ECE2_uc003fnk.3_Missense_Mutation_p.Q269H|ECE2_uc011bri.1_Missense_Mutation_p.Q331H|ECE2_uc010hxv.2_Missense_Mutation_p.Q60H	NM_014693	NP_055508	O60344	ECE2_HUMAN	endothelin converting enzyme 2 isoform A	416	Lumenal (Potential).|Endothelin-converting enzyme 2 region.				brain development|cardioblast differentiation|cell-cell signaling|peptide hormone processing	cytoplasmic vesicle membrane|Golgi membrane|integral to membrane	metal ion binding|metalloendopeptidase activity|methyltransferase activity			ovary(2)|skin(2)	4	all_cancers(143;1.39e-10)|Ovarian(172;0.0339)		Epithelial(37;8.28e-34)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			CGAGGGAGCAGATGCAGCAGG	0.597		NaN											0	0	0	0.001984	0	7	27									
C3orf59	151963	broad.mit.edu	37	3	192516720	192516720	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr3:192516720G>C	uc011bsp.1	-	2	1252	c.931C>G	c.(931-933)CAG>GAG	p.Q311E		NM_178496	NP_848591	Q8IYB1	M21D2_HUMAN	hypothetical protein LOC151963	311											0	all_cancers(143;1.56e-08)|Ovarian(172;0.0634)		OV - Ovarian serous cystadenocarcinoma(49;2.8e-18)|LUSC - Lung squamous cell carcinoma(58;8.04e-06)|Lung(62;8.62e-06)	GBM - Glioblastoma multiforme(46;3.86e-05)		TTGCAGGCCTGATAGGCCTGC	0.557		NaN											0	0	0	0.000978	0	11	44									
SMR3B	10879	broad.mit.edu	37	4	71255498	71255498	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr4:71255498G>C	uc011cas.1	+	3	254	c.173G>C	c.(172-174)AGA>ACA	p.R58T	SMR3B_uc003hfh.2_Missense_Mutation_p.R58T	NM_006685	NP_006676	P02814	SMR3B_HUMAN	submaxillary gland androgen regulated protein 3	58	Pro-rich.					extracellular space		p.R58K(1)		skin(1)	1		all_hematologic(202;0.196)				GGTCCAGGGAGAATCCCACCT	0.602		NaN											0	0	0	0.003755	0	33	47									
PDLIM5	10611	broad.mit.edu	37	4	95561504	95561504	+	Missense_Mutation	SNP	A	A	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr4:95561504A>C	uc003hti.2	+	9	1337	c.1186A>C	c.(1186-1188)ACC>CCC	p.T396P	PDLIM5_uc011cdx.1_Missense_Mutation_p.T293P|PDLIM5_uc003hth.2_Missense_Mutation_p.T287P|PDLIM5_uc003htj.2_Missense_Mutation_p.T71P|PDLIM5_uc003htk.2_Missense_Mutation_p.T425P|PDLIM5_uc011cdy.1_Missense_Mutation_p.T274P|PDLIM5_uc003htl.2_Missense_Mutation_p.T71P	NM_006457	NP_006448	Q96HC4	PDLI5_HUMAN	PDZ and LIM domain 5 isoform a	396					regulation of dendritic spine morphogenesis|regulation of synaptogenesis	actin cytoskeleton|cell junction|cytosol|postsynaptic density|postsynaptic membrane|synaptosome	actin binding|actinin binding|protein kinase C binding|zinc ion binding			ovary(1)|skin(1)	2		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.84e-09)		TTTGGGACAAACCCAGCCAAG	0.493		NaN											0	0	0	0.002445	0	33	42									
CENPE	1062	broad.mit.edu	37	4	104082504	104082504	+	Silent	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr4:104082504C>G	uc003hxb.1	-	19	2043	c.1953G>C	c.(1951-1953)CTG>CTC	p.L651L	CENPE_uc003hxc.1_Silent_p.L626L	NM_001813	NP_001804	Q02224	CENPE_HUMAN	centromere protein E	651	Potential.				blood coagulation|cell division|kinetochore assembly|microtubule-based movement|mitotic chromosome movement towards spindle pole|mitotic metaphase|mitotic metaphase plate congression|mitotic prometaphase|multicellular organismal development|positive regulation of protein kinase activity	condensed chromosome kinetochore|cytosol|microtubule|nucleus|spindle	ATP binding|kinetochore binding|microtubule motor activity			ovary(5)|breast(4)	9				OV - Ovarian serous cystadenocarcinoma(123;2.95e-08)		TTTTCTCCTTCAGCTCCAGAT	0.333		NaN											0	0	0	0.000248	0	4	43									
TET2	54790	broad.mit.edu	37	4	106157172	106157172	+	Silent	SNP	T	T	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr4:106157172T>G	uc003hxk.2	+	3	2459	c.2073T>G	c.(2071-2073)ACT>ACG	p.T691T	TET2_uc011cez.1_Silent_p.T712T|TET2_uc003hxj.2_RNA|TET2_uc010ilp.1_Silent_p.T691T|TET2_uc003hxi.1_Silent_p.T691T	NM_001127208	NP_001120680	Q6N021	TET2_HUMAN	tet oncogene family member 2 isoform a	691	Gln-rich.				cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			haematopoietic_and_lymphoid_tissue(732)|pancreas(1)	733		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		ATTCCCAAACTGAAAAACTTA	0.418		NaN	Mis N|F		MDS								0	0	0	0.00245	0	13	69									
CAMK2D	817	broad.mit.edu	37	4	114434999	114434999	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr4:114434999C>G	uc003ibi.2	-	11	1749	c.890G>C	c.(889-891)AGA>ACA	p.R297T	CAMK2D_uc003ibj.2_Missense_Mutation_p.R297T|CAMK2D_uc003ibk.2_Missense_Mutation_p.R297T|CAMK2D_uc003ibo.3_Missense_Mutation_p.R297T|CAMK2D_uc003ibm.2_Missense_Mutation_p.R297T|CAMK2D_uc003ibn.2_Missense_Mutation_p.R297T|CAMK2D_uc003ibl.2_Missense_Mutation_p.R297T	NM_001221	NP_001212	Q13557	KCC2D_HUMAN	calcium/calmodulin-dependent protein kinase II	297	Calmodulin-binding (By similarity).				interferon-gamma-mediated signaling pathway|regulation of cell growth|synaptic transmission	calcium- and calmodulin-dependent protein kinase complex|cytosol|endocytic vesicle membrane|nucleoplasm|plasma membrane	ATP binding|calmodulin binding|calmodulin-dependent protein kinase activity			ovary(1)	1		Ovarian(17;0.00369)|Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;0.000271)		TAGTTTTCTTCTAGCATTAAA	0.353		NaN											0	0	0	0.000248	0	4	33									
INPP4B	8821	broad.mit.edu	37	4	142949964	142949964	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr4:142949964C>G	uc003iix.3	-	27	3341	c.2746G>C	c.(2746-2748)GAG>CAG	p.E916Q	INPP4B_uc003iiw.3_Missense_Mutation_p.E916Q|INPP4B_uc011chm.1_RNA	NM_003866	NP_003857	O15327	INP4B_HUMAN	inositol polyphosphate-4-phosphatase, type II,	916					signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			ovary(1)|lung(1)	2	all_hematologic(180;0.158)					TAAGTCCCCTCTGGAGGTCTG	0.393		NaN											0	0	0	0.002522	0	40	17									
DCLK2	166614	broad.mit.edu	37	4	151153948	151153948	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr4:151153948G>A	uc003ilm.3	+	10	1634	c.1534G>A	c.(1534-1536)GTG>ATG	p.V512M	DCLK2_uc003iln.3_Missense_Mutation_p.V511M|DCLK2_uc003ilo.3_Missense_Mutation_p.V529M|DCLK2_uc003ilp.3_RNA	NM_001040260	NP_001035350	Q8N568	DCLK2_HUMAN	doublecortin-like kinase 2 isoform a	512	Protein kinase.				intracellular signal transduction	cytoplasm|cytoskeleton	ATP binding|protein serine/threonine kinase activity			ovary(3)	3	all_hematologic(180;0.151)					CCTCAGCATCGTGCACAGAGA	0.458		NaN											0	0	0	0.00361	0	93	67									
DCHS2	54798	broad.mit.edu	37	4	155226351	155226351	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr4:155226351G>A	uc003inw.2	-	16	3928	c.3928C>T	c.(3928-3930)CCA>TCA	p.P1310S		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1310	Cadherin 11.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		GAAGCACCTGGCATGATTTCA	0.343		NaN											0	0	0	0.006122	0	17	15									
C4orf27	54969	broad.mit.edu	37	4	170674911	170674911	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr4:170674911C>T	uc003isl.3	-	2	189	c.124G>A	c.(124-126)GAA>AAA	p.E42K		NM_017867	NP_060337	Q9NWY4	CD027_HUMAN	hypothetical protein LOC54969	42						nucleus				ovary(1)|pancreas(1)	2		Prostate(90;0.00601)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.018)|LUSC - Lung squamous cell carcinoma(193;0.116)		TAATGATTTTCTACTTCTTTT	0.368		NaN											0	0	0	0.008871	0	21	12									
FAT1	2195	broad.mit.edu	37	4	187525001	187525001	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr4:187525001G>C	uc003izf.2	-	19	10867	c.10679C>G	c.(10678-10680)TCA>TGA	p.S3560*		NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	3560	Extracellular (Potential).|Cadherin 33.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						GACGCCACCTGAGTATTCTTC	0.473		NaN								HNSCC(5;0.00058)			0	0	0	0.008361	0	29	19									
ADAMTS16	170690	broad.mit.edu	37	5	5182156	5182156	+	Splice_Site	SNP	G	G	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr5:5182156G>T	uc003jdl.2	+	4	640	c.502_splice	c.e4-1	p.S168_splice	ADAMTS16_uc003jdk.1_Splice_Site_p.S168_splice|ADAMTS16_uc003jdj.1_Splice_Site_p.S168_splice	NM_139056	NP_620687	Q8TE57	ATS16_HUMAN	ADAM metallopeptidase with thrombospondin type 1						proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			ovary(3)|lung(2)|large_intestine(1)|breast(1)|pancreas(1)	8						ATTTTTTCCAGTCAGGCATGA	0.448		NaN											1	0	1.01871e-10	0.008871	1.87147e-10	19	69									
DNAH5	1767	broad.mit.edu	37	5	13916475	13916475	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr5:13916475G>C	uc003jfd.2	-	9	1221	c.1179C>G	c.(1177-1179)ATC>ATG	p.I393M	DNAH5_uc003jfe.1_RNA	NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	393	Stem (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					ACAGAGATGTGATCTTCTCAG	0.303		NaN							Kartagener_syndrome				0	0	0	0.00308	0	7	36									
ANKH	56172	broad.mit.edu	37	5	14746024	14746024	+	Silent	SNP	G	G	A	rs111688928		TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr5:14746024G>A	uc003jfm.3	-	7	1201	c.870C>T	c.(868-870)TAC>TAT	p.Y290Y	ANKH_uc003jfl.3_Silent_p.Y3Y	NM_054027	NP_473368	Q9HCJ1	ANKH_HUMAN	progressive ankylosis protein	290	Cytoplasmic (Potential).				locomotory behavior|regulation of bone mineralization|skeletal system development	integral to plasma membrane|outer membrane	inorganic diphosphate transmembrane transporter activity|inorganic phosphate transmembrane transporter activity			upper_aerodigestive_tract(1)	1						TCAACCAGCCGTATGGCATGT	0.522		NaN											0	0	0	0.008871	0	18	31									
C5orf22	55322	broad.mit.edu	37	5	31535946	31535946	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr5:31535946G>C	uc003jhj.3	+	3	450	c.323G>C	c.(322-324)AGA>ACA	p.R108T	C5orf22_uc011cnw.1_RNA|C5orf22_uc003jhk.3_5'UTR	NM_018356	NP_060826	Q49AR2	CE022_HUMAN	hypothetical protein LOC55322	108										ovary(2)	2						CAGCAGATCAGAGAGGGCAGA	0.383		NaN											0	0	0	0.001855	0	13	37									
UGT3A1	133688	broad.mit.edu	37	5	35954391	35954391	+	Silent	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr5:35954391G>A	uc003jjv.1	-	7	1642	c.1485C>T	c.(1483-1485)CTC>CTT	p.L495L	UGT3A1_uc003jjw.1_RNA	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	495	Helical; (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			TGCCCAGAGTGAGCCCCAGCA	0.587		NaN											0	0	0	0.001168	0	5	27									
SLC1A3	6507	broad.mit.edu	37	5	36671303	36671303	+	Silent	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr5:36671303G>A	uc003jkj.3	+	4	968	c.492G>A	c.(490-492)GTG>GTA	p.V164V	SLC1A3_uc011cox.1_Silent_p.V57V|SLC1A3_uc010iuy.2_Silent_p.V164V	NM_004172	NP_004163	P43003	EAA1_HUMAN	solute carrier family 1 (glial high affinity	164	Extracellular (Potential).				D-aspartate import|L-glutamate import|neurotransmitter uptake	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity				0	all_lung(31;0.000245)		Epithelial(62;0.0444)|Lung(74;0.111)|all cancers(62;0.128)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)		L-Glutamic Acid(DB00142)	TTGTACGAGTGACAGCTGCAG	0.473		NaN											0	0	0	0.006214	0	9	23									
C9	735	broad.mit.edu	37	5	39306727	39306727	+	Missense_Mutation	SNP	T	T	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr5:39306727T>C	uc003jlv.3	-	9	1497	c.1408A>G	c.(1408-1410)AGT>GGT	p.S470G		NM_001737	NP_001728	P02748	CO9_HUMAN	complement component 9 precursor	470	MACPF.				complement activation, alternative pathway|complement activation, classical pathway|cytolysis|hemolysis by symbiont of host erythrocytes	extracellular region|membrane attack complex					0	all_lung(31;0.000197)	all_neural(839;7.57e-10)|Lung NSC(810;2.62e-08)|Ovarian(839;0.00384)|Breast(839;0.0184)|Myeloproliferative disorder(839;0.0511)	Epithelial(62;0.158)			ACTTTTTGACTAATGAGAACA	0.363		NaN											0	0	0	0.007413	0	15	41									
SSBP2	23635	broad.mit.edu	37	5	80911377	80911377	+	Splice_Site	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr5:80911377C>G	uc003kho.2	-	4	409	c.198_splice	c.e4-1	p.C66_splice	SSBP2_uc003khn.2_Splice_Site|SSBP2_uc003khp.2_Splice_Site_p.C66_splice|SSBP2_uc011ctp.1_Splice_Site_p.C66_splice|SSBP2_uc011ctq.1_Splice_Site_p.C66_splice|SSBP2_uc011ctr.1_Splice_Site_p.C66_splice	NM_012446	NP_036578	P81877	SSBP2_HUMAN	single-stranded DNA binding protein 2						regulation of transcription, DNA-dependent	cytoplasm|nucleus	single-stranded DNA binding		SSBP2/JAK2(4)	haematopoietic_and_lymphoid_tissue(4)|skin(1)	5		Lung NSC(167;0.00154)|all_lung(232;0.00179)|Ovarian(174;0.0338)		OV - Ovarian serous cystadenocarcinoma(54;1.07e-41)|Epithelial(54;2.79e-35)|all cancers(79;1.18e-29)		CCAAAATACACTAAAAAAGTA	0.328		NaN											0	0	0	0.001882	0	23	25									
GPR98	84059	broad.mit.edu	37	5	90049511	90049511	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr5:90049511G>C	uc003kju.2	+	54	11338	c.11242G>C	c.(11242-11244)GAG>CAG	p.E3748Q	GPR98_uc003kjt.2_Missense_Mutation_p.E1454Q|GPR98_uc003kjv.2_Missense_Mutation_p.E1348Q	NM_032119	NP_115495	Q8WXG9	GPR98_HUMAN	G protein-coupled receptor 98 precursor	3748	Extracellular (Potential).				cell communication|cell-cell adhesion|maintenance of organ identity|neuropeptide signaling pathway|photoreceptor cell maintenance	cell surface|cytoplasm|integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(11)|central_nervous_system(3)|pancreas(2)	16		all_cancers(142;1.05e-09)|all_epithelial(76;1.81e-12)|all_lung(232;5.41e-06)|Lung NSC(167;1.72e-05)|Ovarian(174;0.00948)|Colorectal(57;0.133)|Breast(839;0.192)		OV - Ovarian serous cystadenocarcinoma(54;7.01e-30)|Epithelial(54;6.79e-25)|all cancers(79;1.88e-20)		AGAAGGGGTTGAGGACTCATA	0.448		NaN											0	0	0	0.001984	0	7	32									
SLCO4C1	353189	broad.mit.edu	37	5	101596009	101596009	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr5:101596009G>C	uc003knm.2	-	6	1323	c.1036C>G	c.(1036-1038)CAA>GAA	p.Q346E		NM_180991	NP_851322	Q6ZQN7	SO4C1_HUMAN	solute carrier organic anion transporter family,	346	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			upper_aerodigestive_tract(1)|ovary(1)|central_nervous_system(1)|pancreas(1)	4		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		TTTCCAGCTTGAATTTCTGCT	0.209		NaN											0	0	0	0.00308	0	8	6									
FBXL17	64839	broad.mit.edu	37	5	107216802	107216802	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr5:107216802C>T	uc011cvc.1	-	8	2308	c.1901G>A	c.(1900-1902)GGA>GAA	p.G634E	FBXL17_uc003kon.3_Missense_Mutation_p.G236E	NM_001163315	NP_001156787	Q9UF56	FXL17_HUMAN	F-box and leucine-rich repeat protein 17	634											0		all_cancers(142;0.00273)|all_epithelial(76;0.000362)|Prostate(80;0.0115)|Myeloproliferative disorder(839;0.0393)|Ovarian(225;0.232)		OV - Ovarian serous cystadenocarcinoma(64;9.63e-11)|Epithelial(69;4.02e-10)		CAGGGTGGCTCCTTGGTCTGT	0.453		NaN											0	0	0	0.001786	0	30	103									
FER	2241	broad.mit.edu	37	5	108516519	108516519	+	Missense_Mutation	SNP	G	G	A	rs151332661		TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr5:108516519G>A	uc003kop.1	+	18	2504	c.2120G>A	c.(2119-2121)CGT>CAT	p.R707H	FER_uc011cvg.1_Missense_Mutation_p.R532H	NM_005246	NP_005237	P16591	FER_HUMAN	fer (fps/fes related) tyrosine kinase	707	Protein kinase.				intracellular signal transduction|peptidyl-tyrosine phosphorylation	cytoplasm|nucleus	ATP binding|non-membrane spanning protein tyrosine kinase activity			lung(2)|stomach(1)|ovary(1)|kidney(1)	5		all_cancers(142;2.86e-06)|all_epithelial(76;9.81e-08)|Prostate(80;0.00972)|Lung NSC(167;0.039)|Ovarian(225;0.0448)|all_lung(232;0.0496)|Colorectal(57;0.0986)|Breast(839;0.152)		OV - Ovarian serous cystadenocarcinoma(64;6.77e-10)|Epithelial(69;4.13e-08)|COAD - Colon adenocarcinoma(37;0.0174)		GGAATGTCTCGTCAAGAGGAT	0.423		NaN											0	0	0	0.002299	0	23	62									
IRF1	3659	broad.mit.edu	37	5	131819667	131819667	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr5:131819667G>C	uc003kxa.2	-	10	1188	c.954C>G	c.(952-954)ATC>ATG	p.I318M	C5orf56_uc010jds.1_Intron|IRF1_uc003kxd.2_Intron|IRF1_uc003kxb.2_Missense_Mutation_p.I318M	NM_002198	NP_002189	P10914	IRF1_HUMAN	interferon regulatory factor 1	318					blood coagulation|cellular response to mechanical stimulus|interferon-gamma-mediated signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	nucleoplasm					0		all_cancers(142;0.026)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)	LUAD - Lung adenocarcinoma(142;0.247)		GAATGGCCTGGATGGAGGGCA	0.587		NaN											0	0	0	0.008291	0	10	25									
PCDHGA6	56109	broad.mit.edu	37	5	140755384	140755384	+	Silent	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr5:140755384G>C	uc003ljy.1	+	1	1734	c.1734G>C	c.(1732-1734)GCG>GCC	p.A578A	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc011dau.1_Silent_p.A578A	NM_018919	NP_061742	Q9Y5G7	PCDG6_HUMAN	protocadherin gamma subfamily A, 6 isoform 1	578	Extracellular (Potential).|Cadherin 6.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGGAGCTGGCGCCCCGCTCCG	0.657		NaN											0	0	0	0.00361	0	46	108									
PCDHGC5	56097	broad.mit.edu	37	5	140890566	140890566	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr5:140890566G>C	uc003lla.1	+	4	2661	c.2661G>C	c.(2659-2661)TTG>TTC	p.L887F	PCDHGA1_uc003lji.1_Missense_Mutation_p.L874F|PCDHGA2_uc003ljk.1_Missense_Mutation_p.L875F|PCDHGA3_uc003ljm.1_Missense_Mutation_p.L875F|PCDHGA3_uc010jfx.1_Missense_Mutation_p.L635F|PCDHGB1_uc003ljo.1_Missense_Mutation_p.L870F|PCDHGA4_uc003ljq.1_Missense_Mutation_p.L874F|PCDHGB2_uc003ljs.1_Missense_Mutation_p.L874F|PCDHGA5_uc003lju.1_Missense_Mutation_p.L874F|PCDHGB3_uc003ljw.1_Missense_Mutation_p.L872F|PCDHGA6_uc003ljy.1_Missense_Mutation_p.L875F|PCDHGA7_uc003lka.1_Missense_Mutation_p.L875F|PCDHGB4_uc003lkc.1_Missense_Mutation_p.L866F|PCDHGA8_uc003lkd.1_Missense_Mutation_p.L875F|PCDHGB5_uc003lkf.1_Missense_Mutation_p.L866F|PCDHGA9_uc003lkh.1_Missense_Mutation_p.L875F|PCDHGB6_uc003lkj.1_Missense_Mutation_p.L873F|PCDHGA10_uc003lkl.1_Missense_Mutation_p.L879F|PCDHGB7_uc003lkn.1_Missense_Mutation_p.L872F|PCDHGA11_uc003lkp.1_Missense_Mutation_p.L693F|PCDHGA11_uc003lkq.1_Missense_Mutation_p.L878F|PCDHGA12_uc003lkt.1_Missense_Mutation_p.L875F|PCDHGC3_uc003lkv.1_Missense_Mutation_p.L877F|PCDHGC3_uc003lkw.1_Missense_Mutation_p.L77F|PCDHGC4_uc003lky.1_Missense_Mutation_p.L881F	NM_018929	NP_061752	Q9Y5F6	PCDGM_HUMAN	protocadherin gamma subfamily C, 5 isoform 1	887	Cytoplasmic (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCATGGGATTGAGCGCCCGCT	0.612		NaN											0	0	0	0.00623	0	37	129									
AFAP1L1	134265	broad.mit.edu	37	5	148709287	148709287	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr5:148709287G>T	uc003lqh.2	+	16	2000	c.1869G>T	c.(1867-1869)TTG>TTT	p.L623F	AFAP1L1_uc010jgy.2_Missense_Mutation_p.L623F|AFAP1L1_uc003lqi.1_Missense_Mutation_p.L238F	NM_152406	NP_689619	Q8TED9	AF1L1_HUMAN	actin filament associated protein 1-like 1	623	Potential.						protein binding			breast(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GGAGGTACTTGGTAGAAAAAG	0.498		NaN											1	0	7.03913e-09	0.001368	1.27715e-08	10	23									
JARID2	3720	broad.mit.edu	37	6	15496706	15496706	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:15496706C>T	uc003nbj.2	+	7	1494	c.1250C>T	c.(1249-1251)TCA>TTA	p.S417L	JARID2_uc011diu.1_Missense_Mutation_p.S281L|JARID2_uc011div.1_Missense_Mutation_p.S245L|JARID2_uc011diw.1_Missense_Mutation_p.S379L	NM_004973	NP_004964	Q92833	JARD2_HUMAN	jumonji, AT rich interactive domain 2 protein	417					central nervous system development|chromatin modification|negative regulation of histone methylation|positive regulation of histone H3-K9 methylation|stem cell differentiation|transcription, DNA-dependent		chromatin binding			ovary(2)|lung(1)|pancreas(1)	4	Breast(50;0.0142)|Ovarian(93;0.103)	all_hematologic(90;0.00612)				AACCCAAAGTCATGCACTAAG	0.652		NaN											0	0	0	0.00499	0	16	47									
LY6G6F	259215	broad.mit.edu	37	6	31685471	31685471	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:31685471C>G	uc003nwb.1	+	6	1039	c.1039C>G	c.(1039-1041)CTG>GTG	p.L347V	LY6G6D_uc003nwf.1_Missense_Mutation_p.L98V|LY6G6D_uc003nwg.1_Missense_Mutation_p.L77V	NM_001003693	NP_001003693	Q5SQ64	LY66F_HUMAN	G6f protein precursor	Error:Variant_position_missing_in_Q5SQ64_after_alignment						integral to membrane|plasma membrane				breast(1)|central_nervous_system(1)	2						GGACTGCTACCTGGGAGACCT	0.597		NaN											0	0	0	0.005524	0	39	109									
RPS18	6222	broad.mit.edu	37	6	33243622	33243622	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:33243622G>A	uc003odp.1	+	3	196	c.151G>A	c.(151-153)GAC>AAC	p.D51N	RPS18_uc010jum.1_RNA|RPS18_uc003odq.1_RNA|B3GALT4_uc003odr.2_5'Flank	NM_022551	NP_072045	P62269	RS18_HUMAN	ribosomal protein S18	51					endocrine pancreas development|ribosome biogenesis|translational elongation|translational termination|viral transcription	cytosolic small ribosomal subunit	rRNA binding|structural constituent of ribosome				0						AGCAGACATTGACCTCACCAA	0.512		NaN											0	0	0	0.006999	0	36	82									
FTSJD2	23070	broad.mit.edu	37	6	37414099	37414099	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:37414099G>T	uc003ons.2	+	4	571	c.318G>T	c.(316-318)TTG>TTT	p.L106F	FTSJD2_uc010jwu.2_Missense_Mutation_p.L106F	NM_015050	NP_055865	Q8N1G2	MTR1_HUMAN	FtsJ methyltransferase domain containing 2	106	G-patch.				mRNA capping	cytoplasm|nucleus	mRNA (nucleoside-2'-O-)-methyltransferase activity|nucleic acid binding			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	5						GTGAAGGATTGGGTAAATACA	0.433		NaN											1	0	0.000673444	0.008291	0.00116149	10	161									
UBE2J1	51465	broad.mit.edu	37	6	90039588	90039588	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:90039588C>T	uc010kcb.2	-	9	940	c.767G>A	c.(766-768)CGG>CAG	p.R256Q	UBE2J1_uc003pnc.2_Missense_Mutation_p.R256Q	NM_016021	NP_057105	Q9Y385	UB2J1_HUMAN	ubiquitin-conjugating enzyme E2, J1	256	Cytoplasmic (Potential).					endoplasmic reticulum membrane|integral to membrane	ATP binding|ubiquitin-protein ligase activity				0		all_cancers(76;1.65e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;2.5e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0139)		CTGCTGGGCCCGGCGCTGTCG	0.517		NaN											0	0	0	0.003163	0	15	40									
MDN1	23195	broad.mit.edu	37	6	90394614	90394614	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:90394614G>A	uc003pnn.1	-	71	11926	c.11810C>T	c.(11809-11811)CCC>CTC	p.P3937L		NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	3937					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		TTTTTCTAGGGGGGAACGAAG	0.388		NaN											0	0	0	0.00245	0	13	30									
C6orf167	253714	broad.mit.edu	37	6	97634396	97634396	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:97634396G>A	uc003ppb.2	-	15	2476	c.2210C>T	c.(2209-2211)TCA>TTA	p.S737L	C6orf167_uc011eaf.1_Missense_Mutation_p.S697L	NM_198468	NP_940870	Q6ZRQ5	MMS22_HUMAN	hypothetical protein LOC253714	737					double-strand break repair via homologous recombination|replication fork processing	nuclear replication fork	protein binding				0		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;7.02e-10)|all_hematologic(75;1.23e-06)|all_epithelial(107;0.148)|Colorectal(196;0.198)		BRCA - Breast invasive adenocarcinoma(108;0.0457)		CGCAAGTTGTGAGAAAGGCAC	0.403		NaN											0	0	0	0.006214	0	9	21									
FYN	2534	broad.mit.edu	37	6	112035566	112035566	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:112035566G>C	uc003pvj.2	-	4	668	c.328C>G	c.(328-330)CAA>GAA	p.Q110E	FYN_uc003pvi.2_Missense_Mutation_p.Q110E|FYN_uc003pvk.2_Missense_Mutation_p.Q110E|FYN_uc003pvh.2_Missense_Mutation_p.Q110E	NM_002037	NP_002028	P06241	FYN_HUMAN	protein-tyrosine kinase fyn isoform a	110	SH3.				axon guidance|calcium ion transport|feeding behavior|interspecies interaction between organisms|intracellular protein kinase cascade|learning|leukocyte migration|platelet activation|regulation of defense response to virus by virus|T cell costimulation|T cell receptor signaling pathway|viral reproduction	cytosol|endosome|plasma membrane	ATP binding|glycoprotein binding|identical protein binding|metal ion binding|non-membrane spanning protein tyrosine kinase activity			lung(5)|central_nervous_system(1)|skin(1)	7		all_cancers(87;1.37e-05)|Acute lymphoblastic leukemia(125;2.15e-07)|all_hematologic(75;5.28e-06)|all_epithelial(87;0.00125)|Colorectal(196;0.0211)		all cancers(137;0.0451)|OV - Ovarian serous cystadenocarcinoma(136;0.0476)|Epithelial(106;0.102)	Dasatinib(DB01254)	TTCAATATTTGAAATTTTTCT	0.438		NaN											0	0	0	0.004482	0	6	33									
ROS1	6098	broad.mit.edu	37	6	117662723	117662723	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:117662723G>C	uc003pxp.1	-	29	4941	c.4742C>G	c.(4741-4743)TCT>TGT	p.S1581C	ROS1_uc011ebi.1_Intron|GOPC_uc003pxq.1_Intron	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	1581	Fibronectin type-III 7.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TGGCTTGTGAGATTCTCTCCA	0.423		NaN	T	GOPC|ROS1	glioblastoma|NSCLC								0	0	0	0.00308	0	8	31									
GRM1	2911	broad.mit.edu	37	6	146708053	146708053	+	Missense_Mutation	SNP	T	T	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:146708053T>A	uc010khw.1	+	7	2100	c.1630T>A	c.(1630-1632)TGC>AGC	p.C544S	GRM1_uc010khv.1_Missense_Mutation_p.C544S|GRM1_uc003qll.2_Missense_Mutation_p.C544S|GRM1_uc011edz.1_Missense_Mutation_p.C544S|GRM1_uc011eea.1_Missense_Mutation_p.C544S	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	544	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	AGTGAGCTGCTGCTGGATTTG	0.408		NaN											0	0	0	0.001984	0	6	21									
MTHFD1L	25902	broad.mit.edu	37	6	151203955	151203955	+	Nonsense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:151203955C>T	uc003qob.2	+	5	743	c.475C>T	c.(475-477)CAG>TAG	p.Q159*	MTHFD1L_uc011een.1_RNA|MTHFD1L_uc011eeo.1_Nonsense_Mutation_p.Q159*|MTHFD1L_uc003qoc.2_Nonsense_Mutation_p.Q106*|MTHFD1L_uc003qoa.1_Nonsense_Mutation_p.Q159*|MTHFD1L_uc010kil.1_RNA	NM_015440	NP_056255	Q6UB35	C1TM_HUMAN	methylenetetrahydrofolate dehydrogenase (NADP+	159	Methylenetetrahydrofolate dehydrogenase and cyclohydrolase.				folic acid-containing compound biosynthetic process|formate metabolic process|one-carbon metabolic process|tetrahydrofolate metabolic process	mitochondrion	ATP binding|formate-tetrahydrofolate ligase activity|protein homodimerization activity			ovary(3)|large_intestine(1)	4		Ovarian(120;0.128)		OV - Ovarian serous cystadenocarcinoma(155;8.7e-12)		CCTTGCCCTTCAGATCTCTGA	0.308		NaN											0	0	0	0.000978	0	11	36									
ZBTB2	57621	broad.mit.edu	37	6	151687786	151687786	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:151687786C>T	uc003qoh.2	-	3	550	c.415G>A	c.(415-417)GAT>AAT	p.D139N		NM_020861	NP_065912	Q8N680	ZBTB2_HUMAN	zinc finger and BTB domain containing 2	139					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1			BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.63e-11)		AACTGATGATCTGCAATCTGA	0.547		NaN											0	0	0	0.008361	0	32	67									
ZDHHC14	79683	broad.mit.edu	37	6	158074650	158074650	+	Silent	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:158074650G>A	uc003qqt.2	+	8	1556	c.1059G>A	c.(1057-1059)CAG>CAA	p.Q353Q	ZDHHC14_uc003qqs.2_Silent_p.Q353Q|ZDHHC14_uc010kjn.2_Silent_p.Q8Q	NM_024630	NP_078906	Q8IZN3	ZDH14_HUMAN	zinc finger, DHHC-type containing 14 isoform 1	353						integral to membrane	acyltransferase activity|zinc ion binding			ovary(1)|skin(1)	2		Breast(66;0.00586)|Ovarian(120;0.123)		OV - Ovarian serous cystadenocarcinoma(65;2.9e-17)|BRCA - Breast invasive adenocarcinoma(81;5.8e-05)		CGCAGTCACAGAGTGACATGG	0.607		NaN											0	0	0	0.001368	0	12	30									
SYTL3	94120	broad.mit.edu	37	6	159166530	159166530	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:159166530G>C	uc003qrp.2	+	11	1118	c.874G>C	c.(874-876)GAC>CAC	p.D292H	SYTL3_uc011efp.1_Missense_Mutation_p.D292H|SYTL3_uc003qro.2_Missense_Mutation_p.D224H|SYTL3_uc003qrq.2_Missense_Mutation_p.D224H|SYTL3_uc003qrr.2_Missense_Mutation_p.D292H|SYTL3_uc003qrs.2_Missense_Mutation_p.D224H|SYTL3_uc011efq.1_Missense_Mutation_p.D18H	NM_001009991	NP_001009991	Q4VX76	SYTL3_HUMAN	synaptotagmin-like 3	292					intracellular protein transport	endomembrane system|membrane	Rab GTPase binding				0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.54e-17)|BRCA - Breast invasive adenocarcinoma(81;8.24e-06)		AATTAGCATTGACAGCACCTG	0.323		NaN											0	0	0	0.00308	0	7	21									
SYTL3	94120	broad.mit.edu	37	6	159166673	159166673	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:159166673G>C	uc003qrp.2	+	11	1261	c.1017G>C	c.(1015-1017)AAG>AAC	p.K339N	SYTL3_uc011efp.1_Missense_Mutation_p.K339N|SYTL3_uc003qro.2_Missense_Mutation_p.K271N|SYTL3_uc003qrq.2_Missense_Mutation_p.K271N|SYTL3_uc003qrr.2_Missense_Mutation_p.K339N|SYTL3_uc003qrs.2_Missense_Mutation_p.K271N|SYTL3_uc011efq.1_Missense_Mutation_p.K65N	NM_001009991	NP_001009991	Q4VX76	SYTL3_HUMAN	synaptotagmin-like 3	339	C2 1.				intracellular protein transport	endomembrane system|membrane	Rab GTPase binding				0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.54e-17)|BRCA - Breast invasive adenocarcinoma(81;8.24e-06)		GAGAAGAAAAGAAGAAAAAGT	0.244		NaN											0	0	0	0.004482	0	7	31									
WTAP	9589	broad.mit.edu	37	6	160169273	160169273	+	Silent	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:160169273G>C	uc003qsl.2	+	6	546	c.324G>C	c.(322-324)CTG>CTC	p.L108L	WTAP_uc010kjx.2_Silent_p.L108L|WTAP_uc003qsk.2_Silent_p.L108L|WTAP_uc003qsm.1_RNA|WTAP_uc003qsn.2_Silent_p.L108L	NM_004906	NP_004897	Q15007	FL2D_HUMAN	Wilms' tumour 1-associating protein isoform 1	108					cell cycle|mRNA processing|RNA splicing	nuclear membrane|nucleolus					0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.75e-18)|BRCA - Breast invasive adenocarcinoma(81;5.93e-06)		TTGCCCAACTGAGATCAACAA	0.418		NaN											0	0	0	0.00245	0	12	39									
MACC1	346389	broad.mit.edu	37	7	20199869	20199869	+	Splice_Site	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:20199869C>T	uc003sus.3	-	5	425	c.116_splice	c.e5-1	p.E39_splice	MACC1_uc010kug.2_Splice_Site_p.E39_splice	NM_182762	NP_877439	Q6ZN28	MACC1_HUMAN	putative binding protein 7a5						positive regulation of cell division|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	growth factor activity			ovary(2)|skin(1)	3						TCCTGGCATTCTTGTTATTTA	0.388		NaN											0	0	0	0.001368	0	13	29									
TRA2A	29896	broad.mit.edu	37	7	23571441	23571441	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:23571441C>T	uc003swi.2	-	1	217	c.3G>A	c.(1-3)ATG>ATA	p.M1I	TRA2A_uc011jzb.1_RNA|TRA2A_uc011jzc.1_5'UTR|TRA2A_uc011jzd.1_5'UTR|TRA2A_uc010kuo.1_RNA	NM_013293	NP_037425	Q13595	TRA2A_HUMAN	transformer-2 alpha	1					nuclear mRNA splicing, via spliceosome	nucleus	nucleotide binding|RNA binding			ovary(1)	1						CCACATCACTCATGTCGACGA	0.582		NaN											0	0	0	0.001882	0	19	40									
NEUROD6	63974	broad.mit.edu	37	7	31378699	31378699	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:31378699C>T	uc003tch.2	-	2	537	c.184G>A	c.(184-186)GAG>AAG	p.E62K		NM_022728	NP_073565	Q96NK8	NDF6_HUMAN	neurogenic differentiation 6	62	Poly-Glu.				cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)	2						ctgtcttcctcctcttcttct	0.323		NaN											0	0	0	0.00361	0	54	83									
NEUROD6	63974	broad.mit.edu	37	7	31378712	31378712	+	Silent	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:31378712C>T	uc003tch.2	-	2	524	c.171G>A	c.(169-171)GAG>GAA	p.E57E		NM_022728	NP_073565	Q96NK8	NDF6_HUMAN	neurogenic differentiation 6	57	Poly-Glu.				cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)	2						cttcttctttctcggtttctt	0.323		NaN											0	0	0	0.00361	0	58	80									
AMPH	273	broad.mit.edu	37	7	38431490	38431490	+	Silent	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:38431490G>A	uc003tgu.2	-	19	1806	c.1737C>T	c.(1735-1737)AGC>AGT	p.S579S	AMPH_uc003tgv.2_Silent_p.S537S|AMPH_uc003tgt.2_Silent_p.S464S|AMPH_uc003tgw.1_Silent_p.S602S|AMPH_uc010kxl.1_RNA	NM_001635	NP_001626	P49418	AMPH_HUMAN	amphiphysin isoform 1	579					endocytosis|synaptic transmission	actin cytoskeleton|cell junction|synaptic vesicle membrane				ovary(3)|liver(1)|skin(1)	5						CCGGTGTCTCGCTGGTGGGGC	0.612		NaN											0	0	0	0.001855	0	13	25									
ZNF479	90827	broad.mit.edu	37	7	57193755	57193755	+	Nonsense_Mutation	SNP	T	T	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:57193755T>A	uc010kzo.2	-	4	503	c.232A>T	c.(232-234)AAG>TAG	p.K78*		NM_033273	NP_150376	Q96JC4	ZN479_HUMAN	zinc finger protein 479	78	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|skin(1)	4			GBM - Glioblastoma multiforme(1;9.18e-12)			TCATTTCTCTTTATATTCTGG	0.408		NaN											0	0	0	0.003755	0	29	90									
HIP1	3092	broad.mit.edu	37	7	75190635	75190635	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:75190635C>G	uc003uds.1	-	13	1230	c.1189G>C	c.(1189-1191)GAG>CAG	p.E397Q	HIP1_uc011kfz.1_Missense_Mutation_p.E274Q	NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	397	Potential.				activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						AGTTATACCTCAGTCTTCATG	0.378		NaN	T	PDGFRB	CMML								0	0	0	0.006999	0	39	125									
PION	54103	broad.mit.edu	37	7	76982908	76982908	+	Silent	SNP	G	G	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:76982908G>T	uc003ugf.2	-	17	1468	c.1389C>A	c.(1387-1389)CTC>CTA	p.L463L	PION_uc003ugg.1_Silent_p.L248L	NM_017439	NP_059135	A4D1B5	GSAP_HUMAN	pigeon homolog	463					beta-amyloid formation|regulation of proteolysis	trans-Golgi network	beta-amyloid binding			central_nervous_system(1)	1						ATTCCTGAATGAGGTCAAATG	0.373		NaN											1	0	6.72482e-11	0.003163	1.23852e-10	15	41									
PCLO	27445	broad.mit.edu	37	7	82390090	82390090	+	Silent	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:82390090C>G	uc003uhx.2	-	24	15442	c.15153G>C	c.(15151-15153)GTG>GTC	p.V5051V		NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4974	C2 2.				cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CATATATTTTCACATATAAAT	0.284		NaN											0	0	0	0.000248	0	4	9									
KIAA1324L	222223	broad.mit.edu	37	7	86548627	86548627	+	Splice_Site	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:86548627C>T	uc011kha.1	-	11	1585	c.1400_splice	c.e11-1	p.G467_splice	KIAA1324L_uc003uif.1_Splice_Site_p.G227_splice|KIAA1324L_uc011kgz.1_Splice_Site_p.G353_splice|KIAA1324L_uc003uie.2_Splice_Site_p.G300_splice	NM_001142749	NP_001136221	A8MWY0	K132L_HUMAN	hypothetical protein LOC222223 isoform 1							integral to membrane				ovary(6)|skin(1)	7	Esophageal squamous(14;0.0058)					ACCTCCCAACCTAGAAGTAAT	0.333		NaN											0	0	0	0.000978	0	11	15									
C7orf63	79846	broad.mit.edu	37	7	89887468	89887468	+	Silent	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:89887468G>A	uc010lep.2	+	3	488	c.237G>A	c.(235-237)CAG>CAA	p.Q79Q	C7orf63_uc003ukf.2_RNA|C7orf63_uc003ukg.2_5'UTR|C7orf63_uc011khj.1_Silent_p.Q79Q|C7orf63_uc010leo.2_Silent_p.Q79Q	NM_001039706	NP_001034795	A5D8W1	CG063_HUMAN	hypothetical protein LOC79846 isoform 1	79							binding			ovary(1)	1						AGTGTTATCAGAATGGACTTG	0.244		NaN											0	0	0	0.008291	0	11	25									
CASD1	64921	broad.mit.edu	37	7	94175012	94175012	+	Silent	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:94175012C>T	uc003uni.3	+	12	1859	c.1632C>T	c.(1630-1632)AAC>AAT	p.N544N	CASD1_uc003unj.3_Silent_p.N544N	NM_022900	NP_075051	Q96PB1	CASD1_HUMAN	CAS1 domain containing 1 precursor	544						integral to membrane				ovary(2)	2	all_cancers(62;6.71e-10)|all_epithelial(64;5e-09)|Lung NSC(181;0.188)|all_lung(186;0.215)		STAD - Stomach adenocarcinoma(171;0.0031)			AAAAAGCAAACGGTAAATATA	0.284		NaN											0	0	0	0.006214	0	10	16									
LMTK2	22853	broad.mit.edu	37	7	97821646	97821646	+	Silent	SNP	C	C	T	rs141759251		TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:97821646C>T	uc003upd.1	+	11	2162	c.1869C>T	c.(1867-1869)CAC>CAT	p.H623H		NM_014916	NP_055731	Q8IWU2	LMTK2_HUMAN	lemur tyrosine kinase 2 precursor	623					early endosome to late endosome transport|endocytic recycling|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|protein autophosphorylation|receptor recycling|transferrin transport	early endosome|Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|recycling endosome	ATP binding|myosin VI binding|protein phosphatase inhibitor activity|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(9)|stomach(3)|pancreas(2)|large_intestine(1)|breast(1)	16	all_cancers(62;3.23e-09)|all_epithelial(64;7.65e-10)|Lung NSC(181;0.00902)|all_lung(186;0.0104)|Esophageal squamous(72;0.0125)					GGGACTTACACGTGACCAGTG	0.468		NaN											0	0	0	0.00499	0	17	48									
ZNF655	79027	broad.mit.edu	37	7	99158255	99158255	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:99158255G>C	uc003urh.2	+	2	466	c.73G>C	c.(73-75)GAG>CAG	p.E25Q	FAM200A_uc003urb.2_5'Flank|ZNF655_uc003urf.2_RNA|ZNF655_uc003urc.2_Missense_Mutation_p.E25Q|ZNF655_uc010lfz.2_Missense_Mutation_p.E25Q|ZNF655_uc003ure.2_RNA|ZNF655_uc010lga.2_Missense_Mutation_p.E25Q|ZNF655_uc010lgb.2_Missense_Mutation_p.E25Q|ZNF655_uc003uri.2_Missense_Mutation_p.E25Q|ZNF655_uc010lgc.2_Missense_Mutation_p.E25Q|ZNF655_uc003urj.2_Missense_Mutation_p.E25Q	NM_138494	NP_612503	Q8N720	ZN655_HUMAN	zinc finger protein 655 isoform a	25					G1 phase|regulation of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			ovary(1)	1	all_epithelial(64;3.19e-09)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					GACCCAGTCTGAGTGTCTGTC	0.562		NaN											0	0	0	0.00333	0	22	49									
CTTNBP2	83992	broad.mit.edu	37	7	117431626	117431626	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:117431626G>A	uc003vjf.2	-	4	1716	c.1624C>T	c.(1624-1626)CCT>TCT	p.P542S		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	542	Pro-rich.									ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		ATAGGAGGAGGATTTCCTCTG	0.547		NaN											0	0	0	0.005524	0	38	104									
CTTNBP2	83992	broad.mit.edu	37	7	117450981	117450981	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:117450981G>C	uc003vjf.2	-	3	344	c.252C>G	c.(250-252)TTC>TTG	p.F84L		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	84										ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		GGAGTGCCAGGAACGGGTCAT	0.458		NaN											0	0	0	0.007413	0	19	57									
FLNC	2318	broad.mit.edu	37	7	128489029	128489029	+	Silent	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:128489029C>T	uc003vnz.3	+	28	5129	c.4920C>T	c.(4918-4920)CTC>CTT	p.L1640L	FLNC_uc003voa.3_Silent_p.L1640L	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	1640	Filamin 15.			L -> T (in Ref. 9; CAA49689).	cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						GCAAGTGCCTCGTCACAGGTG	0.657		NaN											0	0	0	0.002096	0	28	54									
TNPO3	23534	broad.mit.edu	37	7	128614995	128614995	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:128614995G>C	uc003vol.1	-	18	2574	c.2200C>G	c.(2200-2202)CAG>GAG	p.Q734E	TNPO3_uc010llx.1_Missense_Mutation_p.Q145E|TNPO3_uc003vom.1_Missense_Mutation_p.Q668E|TNPO3_uc010lly.1_Missense_Mutation_p.Q768E|TNPO3_uc010llz.1_Missense_Mutation_p.Q670E	NM_012470	NP_036602	Q9Y5L0	TNPO3_HUMAN	transportin 3	734					splicing factor protein import into nucleus	cytoplasm|nucleus	protein binding|receptor activity			ovary(2)|skin(2)|lung(1)	5						TCTAGGAGCTGAAAGGTGGGG	0.428		NaN											0	0	0	0.002299	0	21	50									
TSGA14	95681	broad.mit.edu	37	7	130038848	130038848	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:130038848C>G	uc003vpz.2	-	11	1053	c.1006G>C	c.(1006-1008)GAG>CAG	p.E336Q	TSGA14_uc003vpy.2_Missense_Mutation_p.E98Q|TSGA14_uc010lmf.2_Missense_Mutation_p.E133Q|TSGA14_uc003vqa.2_Missense_Mutation_p.E264Q|TSGA14_uc011kpg.1_Missense_Mutation_p.E248Q	NM_018718	NP_061188	Q9BYV8	CEP41_HUMAN	testis specific, 14	336					G2/M transition of mitotic cell cycle	centrosome|cytosol					0	Melanoma(18;0.0435)					ACCTTGGACTCTCTTCCGGAG	0.587		NaN											0	0	0	0.00361	0	53	128									
MLL3	58508	broad.mit.edu	37	7	151846037	151846037	+	Silent	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr7:151846037C>T	uc003wla.2	-	52	13194	c.12975G>A	c.(12973-12975)CTG>CTA	p.L4325L	MLL3_uc003wkz.2_Silent_p.L3443L|MLL3_uc003wkx.2_Silent_p.L483L|MLL3_uc003wky.2_Silent_p.L1889L	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	4325					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		CTGTCACCTTCAGCTCATCTG	0.542		NaN	N		medulloblastoma								0	0	0	0.000602	0	5	25									
ST18	9705	broad.mit.edu	37	8	53084872	53084872	+	Silent	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr8:53084872C>T	uc003xqz.2	-	5	705	c.549G>A	c.(547-549)CAG>CAA	p.Q183Q	ST18_uc011ldq.1_5'UTR|ST18_uc011ldr.1_Silent_p.Q148Q|ST18_uc011lds.1_Silent_p.Q88Q|ST18_uc003xra.2_Silent_p.Q183Q|ST18_uc003xrb.2_Silent_p.Q183Q	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	183						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				AGAAGGGTGGCTGAGAATCAT	0.448		NaN											0	0	0	0.007291	0	31	74									
ARFGEF1	10565	broad.mit.edu	37	8	68112663	68112663	+	Silent	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr8:68112663G>A	uc003xxo.1	-	38	5743	c.5353C>T	c.(5353-5355)CTA>TTA	p.L1785L	ARFGEF1_uc003xxl.1_Silent_p.L1239L|ARFGEF1_uc003xxm.1_Silent_p.L188L|ARFGEF1_uc003xxn.1_Silent_p.L730L|ARFGEF1_uc003xxp.1_Silent_p.L47L	NM_006421	NP_006412	Q9Y6D6	BIG1_HUMAN	brefeldin A-inhibited guanine	1785					exocytosis|regulation of ARF protein signal transduction	cytoplasm	ARF guanyl-nucleotide exchange factor activity|myosin binding			ovary(4)|upper_aerodigestive_tract(1)|large_intestine(1)|lung(1)|kidney(1)	8	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.0043)|OV - Ovarian serous cystadenocarcinoma(28;0.00578)|all cancers(69;0.0173)|BRCA - Breast invasive adenocarcinoma(89;0.206)			ACTTTAGTTAGAAACAAAAGC	0.433		NaN											0	0	0	0.003163	0	15	47									
PREX2	80243	broad.mit.edu	37	8	69030845	69030845	+	Silent	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr8:69030845C>T	uc003xxv.1	+	27	3414	c.3387C>T	c.(3385-3387)TGC>TGT	p.C1129C		NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	1129					G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						GCAGCCAGTGCAGCTCGTATT	0.448		NaN											0	0	0	0.002445	0	31	71									
LRRCC1	85444	broad.mit.edu	37	8	86041588	86041588	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr8:86041588C>A	uc003ycw.2	+	10	1754	c.1600C>A	c.(1600-1602)CAA>AAA	p.Q534K	LRRCC1_uc010lzz.1_Intron|LRRCC1_uc010maa.1_Missense_Mutation_p.Q235K|LRRCC1_uc003ycx.2_Missense_Mutation_p.Q441K|LRRCC1_uc003ycy.2_Missense_Mutation_p.Q514K	NM_033402	NP_208325	Q9C099	LRCC1_HUMAN	sodium channel associated protein 2 isoform a	534	Potential.				cell division|mitosis	centriole|nucleus					0						AATGGAGAGACAAAAAAGGCA	0.328		NaN											1	0	3.69857e-22	0.008361	7.00529e-22	28	84									
KCNQ3	3786	broad.mit.edu	37	8	133153445	133153445	+	Missense_Mutation	SNP	A	A	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr8:133153445A>C	uc003ytj.2	-	10	1621	c.1396T>G	c.(1396-1398)TTA>GTA	p.L466V	KCNQ3_uc010mdt.2_Missense_Mutation_p.L466V	NM_004519	NP_004510	O43525	KCNQ3_HUMAN	potassium voltage-gated channel KQT-like protein	466					axon guidance|synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	5	Esophageal squamous(12;0.00507)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			TTATTGTTTAAGCCAACAGGC	0.443		NaN											0	0	0	0.002836	0	30	78									
PTP4A3	11156	broad.mit.edu	37	8	142437047	142437047	+	Silent	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr8:142437047G>A	uc003ywg.1	+	3	541	c.207G>A	c.(205-207)CCG>CCA	p.P69P	PTP4A3_uc003ywh.1_Silent_p.P69P|PTP4A3_uc010met.1_Intron	NM_032611	NP_116000	O75365	TP4A3_HUMAN	protein tyrosine phosphatase type IVA, member 3	69						early endosome|plasma membrane	identical protein binding|prenylated protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0	all_cancers(97;2.55e-15)|all_epithelial(106;1.39e-13)|Lung NSC(106;2.07e-05)|all_lung(105;2.89e-05)|Ovarian(258;0.0303)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0474)			AGGACTGGCCGTTTGACGATG	0.672		NaN											0	0	0	0.00361	0	61	100									
FAM83H	286077	broad.mit.edu	37	8	144808670	144808670	+	Silent	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr8:144808670G>A	uc003yzk.2	-	5	3030	c.2961C>T	c.(2959-2961)TTC>TTT	p.F987F	FAM83H_uc010mfk.1_RNA	NM_198488	NP_940890	Q6ZRV2	FA83H_HUMAN	FAM83H	987					biomineral tissue development					lung(1)|central_nervous_system(1)|pancreas(1)	3	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;3.38e-41)|Epithelial(56;6.8e-40)|all cancers(56;6.43e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			GCGGCACTGGGAAGCCACCCT	0.697		NaN											0	0	0	0.000602	0	4	20									
PLEC	5339	broad.mit.edu	37	8	144991585	144991585	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr8:144991585G>T	uc003zaf.1	-	32	12985	c.12815C>A	c.(12814-12816)TCC>TAC	p.S4272Y	PLEC_uc003zab.1_Missense_Mutation_p.S4135Y|PLEC_uc003zac.1_Missense_Mutation_p.S4139Y|PLEC_uc003zad.2_Missense_Mutation_p.S4135Y|PLEC_uc003zae.1_Missense_Mutation_p.S4103Y|PLEC_uc003zag.1_Missense_Mutation_p.S4113Y|PLEC_uc003zah.2_Missense_Mutation_p.S4121Y|PLEC_uc003zaj.2_Missense_Mutation_p.S4162Y	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	4272	Binding to intermediate filaments (By similarity).|Globular 2.|Plectin 27.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CTTGCGCACGGAGGACTTGGA	0.617		NaN											1	0	1.15088e-07	0.004007	2.06763e-07	16	34									
PLEC	5339	broad.mit.edu	37	8	145002057	145002057	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr8:145002057G>C	uc003zaf.1	-	26	3945	c.3775C>G	c.(3775-3777)CTC>GTC	p.L1259V	PLEC_uc003zab.1_Missense_Mutation_p.L1122V|PLEC_uc003zac.1_Missense_Mutation_p.L1126V|PLEC_uc003zad.2_Missense_Mutation_p.L1122V|PLEC_uc003zae.1_Missense_Mutation_p.L1090V|PLEC_uc003zag.1_Missense_Mutation_p.L1100V|PLEC_uc003zah.2_Missense_Mutation_p.L1108V|PLEC_uc003zaj.2_Missense_Mutation_p.L1149V	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	1259	Globular 1.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						AGCTCCGGGAGGGTGGCCGGC	0.692		NaN											0	0	0	0.000602	0	4	5									
DOCK8	81704	broad.mit.edu	37	9	328082	328082	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:328082C>T	uc003zgf.2	+	9	1067	c.955C>T	c.(955-957)CAC>TAC	p.H319Y	DOCK8_uc011lls.1_Missense_Mutation_p.H319Y|DOCK8_uc010mgu.2_5'UTR|DOCK8_uc010mgv.2_Missense_Mutation_p.H251Y|DOCK8_uc003zgg.2_Missense_Mutation_p.H251Y|DOCK8_uc003zgh.2_RNA	NM_203447	NP_982272	Q8NF50	DOCK8_HUMAN	dedicator of cytokinesis 8	319					blood coagulation	cytosol	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)	6		all_cancers(5;2.13e-17)|all_epithelial(5;2.15e-12)|all_lung(10;6.69e-11)|Lung NSC(10;1.08e-10)|Acute lymphoblastic leukemia(5;0.000242)|all_hematologic(5;0.00317)|Breast(48;0.0151)|Prostate(43;0.128)		all cancers(5;9.3e-07)|GBM - Glioblastoma multiforme(5;2.41e-06)|Epithelial(6;0.00557)|Lung(218;0.00942)		TCTGCGAGCTCACACGCCTTC	0.458		NaN											0	0	0	0.000978	0	12	71									
RRAGA	10670	broad.mit.edu	37	9	19050318	19050318	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:19050318G>C	uc003znj.2	+	1	947	c.661G>C	c.(661-663)GAG>CAG	p.E221Q		NM_006570	NP_006561	Q7L523	RRAGA_HUMAN	Ras-related GTP binding A	221					apoptosis|cellular protein localization|cellular response to amino acid stimulus|positive regulation of cytolysis|positive regulation of TOR signaling cascade|virus-host interaction	Golgi apparatus|lysosome|nucleus	GTP binding|phosphoprotein binding|protein heterodimerization activity|protein homodimerization activity				0						CCAGTGCAAAGAGCAGCGCGA	0.478		NaN											0	0	0	0.006999	0	36	117									
RUSC2	9853	broad.mit.edu	37	9	35561306	35561306	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:35561306C>T	uc003zww.2	+	12	4733	c.4478C>T	c.(4477-4479)TCT>TTT	p.S1493F	RUSC2_uc010mkq.2_RNA|RUSC2_uc003zwx.3_Missense_Mutation_p.S1493F	NM_014806	NP_055621	Q8N2Y8	RUSC2_HUMAN	RUN and SH3 domain containing 2	1493	SH3.					cytosol				ovary(1)	1			Lung(28;0.000837)|LUSC - Lung squamous cell carcinoma(32;0.00109)|STAD - Stomach adenocarcinoma(86;0.194)			GGCCCCGACTCTGGCCTGGTG	0.647		NaN											0	0	0	0.007291	0	25	87									
RECK	8434	broad.mit.edu	37	9	36110040	36110040	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:36110040G>A	uc003zyv.2	+	15	1938	c.1852G>A	c.(1852-1854)GAG>AAG	p.E618K	RECK_uc003zyw.2_Missense_Mutation_p.E490K|RECK_uc003zyx.2_RNA	NM_021111	NP_066934	O95980	RECK_HUMAN	RECK protein precursor	618						anchored to membrane|peripheral to membrane of membrane fraction|plasma membrane	metalloendopeptidase inhibitor activity|serine-type endopeptidase inhibitor activity			skin(2)|ovary(1)	3			LUSC - Lung squamous cell carcinoma(32;0.112)|STAD - Stomach adenocarcinoma(86;0.228)			TTGCCTCAGTGAGCACAGTTC	0.478		NaN											0	0	0	0.002096	0	34	122									
CEP78	84131	broad.mit.edu	37	9	80881596	80881596	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:80881596C>G	uc004akx.2	+	15	2312	c.2036C>G	c.(2035-2037)TCT>TGT	p.S679C	CEP78_uc004aky.3_Missense_Mutation_p.S696C|CEP78_uc010mpp.2_Missense_Mutation_p.S680C|CEP78_uc004akz.1_Missense_Mutation_p.S167C	NM_032171	NP_115547	Q5JTW2	CEP78_HUMAN	centrosomal protein 78kDa isoform b	679					G2/M transition of mitotic cell cycle	centrosome|cytosol				ovary(1)	1						AGCAGATCTTCTTCAGAGAAA	0.418		NaN											0	0	0	0.001984	0	5	19									
TLE4	7091	broad.mit.edu	37	9	82335206	82335206	+	Silent	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:82335206G>A	uc004ald.2	+	17	2760	c.1911G>A	c.(1909-1911)GTG>GTA	p.V637V	TLE4_uc004alc.2_Silent_p.V612V|TLE4_uc010mpr.2_Silent_p.V491V|TLE4_uc004ale.2_Silent_p.V249V|TLE4_uc011lsq.1_Silent_p.V580V|TLE4_uc010mps.2_Silent_p.V536V|TLE4_uc004alf.2_Silent_p.V551V	NM_007005	NP_008936	O60756	BCE1_HUMAN	transducin-like enhancer protein 4	Error:Variant_position_missing_in_O60756_after_alignment										lung(2)|ovary(1)|breast(1)|skin(1)	5						AGACCTTGGTGAGGTAGGTTA	0.458		NaN											0	0	0	0.000978	0	12	40									
BICD2	23299	broad.mit.edu	37	9	95482616	95482616	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:95482616G>C	uc004aso.1	-	4	1085	c.1028C>G	c.(1027-1029)TCT>TGT	p.S343C	BICD2_uc004asp.1_Missense_Mutation_p.S343C	NM_015250	NP_056065	Q8TD16	BICD2_HUMAN	bicaudal D homolog 2 isoform 2	343	Potential.				microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule	cytoplasmic vesicle|cytoskeleton|Golgi apparatus|plasma membrane	Rab GTPase binding			skin(1)	1						CTGGATCTCAGAGATGTTGAG	0.632		NaN											0	0	0	0.007291	0	29	38									
BICD2	23299	broad.mit.edu	37	9	95482948	95482948	+	Silent	SNP	G	G	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:95482948G>T	uc004aso.1	-	4	753	c.696C>A	c.(694-696)CTC>CTA	p.L232L	BICD2_uc004asp.1_Silent_p.L232L	NM_015250	NP_056065	Q8TD16	BICD2_HUMAN	bicaudal D homolog 2 isoform 2	232	Potential.				microtubule anchoring at microtubule organizing center|minus-end-directed organelle transport along microtubule	cytoplasmic vesicle|cytoskeleton|Golgi apparatus|plasma membrane	Rab GTPase binding			skin(1)	1						AGATCTCCTTGAGGCGGATGG	0.587		NaN											1	0	1.06522e-23	0.003214	2.02807e-23	44	63									
GABBR2	9568	broad.mit.edu	37	9	101125057	101125057	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:101125057G>C	uc004ays.2	-	13	1989	c.1833C>G	c.(1831-1833)ATC>ATG	p.I611M		NM_005458	NP_005449	O75899	GABR2_HUMAN	G protein-coupled receptor 51 precursor	611	Helical; Name=4; (Potential).				negative regulation of adenylate cyclase activity|synaptic transmission	cell junction|integral to plasma membrane|postsynaptic membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(2)|skin(2)	4		Acute lymphoblastic leukemia(62;0.0527)			Baclofen(DB00181)	AGCAGATCAGGATACACAGGT	0.592		NaN											0	0	0	0.00308	0	8	34									
TEX10	54881	broad.mit.edu	37	9	103092428	103092428	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:103092428G>C	uc004bas.2	-	6	1489	c.1274C>G	c.(1273-1275)TCC>TGC	p.S425C	TEX10_uc011lvf.1_Missense_Mutation_p.S264C|TEX10_uc011lvg.1_Missense_Mutation_p.S428C|TEX10_uc011lvh.1_Missense_Mutation_p.S360C	NM_017746	NP_060216	Q9NXF1	TEX10_HUMAN	testis expressed 10 isoform 1	425						integral to membrane|MLL1 complex|nuclear membrane|nucleolus	binding			ovary(1)|skin(1)	2		Acute lymphoblastic leukemia(62;0.0527)		OV - Ovarian serous cystadenocarcinoma(323;0.157)		TATGTTATTGGAGAGAACTGT	0.373		NaN											0	0	0	0.002522	0	38	95									
OR13C3	138803	broad.mit.edu	37	9	107298443	107298443	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:107298443C>A	uc004bcb.1	-	1	652	c.652G>T	c.(652-654)GCC>TCC	p.A218S		NM_001001961	NP_001001961	Q8NGS6	O13C3_HUMAN	olfactory receptor, family 13, subfamily C,	218	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(1)	1						TCAGCACAGGCCAGCTTGAGG	0.383		NaN											1	0	2.44723e-14	0.004656	4.56443e-14	26	76									
SNX30	401548	broad.mit.edu	37	9	115567234	115567234	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:115567234G>C	uc004bgj.3	+	2	483	c.335G>C	c.(334-336)AGG>ACG	p.R112T		NM_001012994	NP_001013012	Q5VWJ9	SNX30_HUMAN	sorting nexin family member 30	112	PX.				cell communication|protein transport	cytoplasm	phosphatidylinositol binding				0						ATCACCTATAGGATCACCACC	0.458		NaN											0	0	0	0.004878	0	31	84									
SLC46A2	57864	broad.mit.edu	37	9	115652749	115652749	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:115652749C>G	uc004bgk.2	-	1	445	c.213G>C	c.(211-213)CAG>CAC	p.Q71H		NM_033051	NP_149040	Q9BY10	TSCOT_HUMAN	solute carrier family 46, member 2	71	Extracellular (Potential).					integral to membrane|plasma membrane	symporter activity			central_nervous_system(1)	1						AGATGGCTCTCTGCTGTTGGT	0.632		NaN											0	0	0	0.00361	0	79	99									
AKNA	80709	broad.mit.edu	37	9	117122258	117122258	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:117122258C>G	uc004biq.3	-	9	2344	c.2209G>C	c.(2209-2211)GAG>CAG	p.E737Q	AKNA_uc004bin.3_5'UTR|AKNA_uc004bio.3_Missense_Mutation_p.E197Q|AKNA_uc004bip.3_Missense_Mutation_p.E656Q|AKNA_uc004bir.3_Missense_Mutation_p.E737Q|AKNA_uc004bis.3_Missense_Mutation_p.E737Q|AKNA_uc010mve.2_Missense_Mutation_p.E618Q|AKNA_uc004biu.1_Missense_Mutation_p.E478Q|AKNA_uc004biv.1_Missense_Mutation_p.E737Q	NM_030767	NP_110394	Q7Z591	AKNA_HUMAN	AT-hook transcription factor	737					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(4)|central_nervous_system(2)	6						GGCCTGTCCTCCACCTCACTG	0.622		NaN											0	0	0	0.000978	0	12	53									
MEGF9	1955	broad.mit.edu	37	9	123476225	123476225	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:123476225G>C	uc004bkj.1	-	1	388	c.388C>G	c.(388-390)CAG>GAG	p.Q130E	MEGF9_uc011lyb.1_Missense_Mutation_p.Q130E|MEGF9_uc004bkk.3_Missense_Mutation_p.Q130E	NM_001080497	NP_001073966	Q9H1U4	MEGF9_HUMAN	multiple EGF-like-domains 9	138	Extracellular (Potential).|Pro-rich.					integral to membrane	calcium ion binding				0						GTCGGCGCCTGAGAGGTGGTC	0.721		NaN											0	0	0	0.008871	0	18	30									
CRB2	286204	broad.mit.edu	37	9	126128232	126128232	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:126128232C>T	uc004bnx.1	+	3	547	c.455C>T	c.(454-456)TCA>TTA	p.S152L	CRB2_uc004bnw.1_Missense_Mutation_p.S152L	NM_173689	NP_775960	Q5IJ48	CRUM2_HUMAN	crumbs homolog 2 precursor	152	Extracellular (Potential).|EGF-like 3; calcium-binding (Potential).					extracellular region|integral to membrane|plasma membrane	calcium ion binding			ovary(1)	1						GAGTGCGCCTCAGCGCCCTGC	0.706		NaN											0	0	0	0.004007	0	11	22									
DNM1	1759	broad.mit.edu	37	9	130984548	130984548	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:130984548G>C	uc011mau.1	+	7	1009	c.922G>C	c.(922-924)GAG>CAG	p.E308Q	DNM1_uc010mxr.2_Missense_Mutation_p.E308Q|DNM1_uc011mat.1_Missense_Mutation_p.E308Q	NM_004408	NP_004399	Q05193	DYN1_HUMAN	dynamin 1 isoform 1	308					receptor-mediated endocytosis	microtubule	GTP binding|GTPase activity			ovary(2)	2						ACTGTCCATTGAGAAGGAGGT	0.582		NaN											0	0	0	0.001523	0	19	66									
SLC27A4	10999	broad.mit.edu	37	9	131115460	131115460	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:131115460G>C	uc004but.2	+	8	1428	c.1144G>C	c.(1144-1146)GAG>CAG	p.E382Q	SLC27A4_uc004buu.2_Intron	NM_005094	NP_005085	Q6P1M0	S27A4_HUMAN	solute carrier family 27 (fatty acid	382					long-chain fatty acid transport|transmembrane transport	integral to membrane	fatty acid transporter activity|nucleotide binding|protein binding				0						CCAGGTGGCTGAGTTCTACGG	0.622		NaN											0	0	0	0.003163	0	15	42									
ZER1	10444	broad.mit.edu	37	9	131504959	131504959	+	Silent	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:131504959G>A	uc004bwa.1	-	9	1858	c.1425C>T	c.(1423-1425)TAC>TAT	p.Y475Y		NM_006336	NP_006327	Q7Z7L7	ZER1_HUMAN	zyg-11 homolog B (C. elegans)-like	475					ATP hydrolysis coupled proton transport|regulation of ubiquitin-protein ligase activity	Cul2-RING ubiquitin ligase complex|vacuolar proton-transporting V-type ATPase, V1 domain	protein binding|proton-transporting ATPase activity, rotational mechanism|ubiquitin-protein ligase activity			ovary(1)	1						TGACCCGGCGGTACTGGAATT	0.632		NaN											0	0	0	0.001855	0	12	18									
ARSD	414	broad.mit.edu	37	X	2836237	2836237	+	Silent	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:2836237G>A	uc004cqy.2	-	5	547	c.471C>T	c.(469-471)TCC>TCT	p.S157S	ARSD_uc004cqz.1_Intron|ARSD_uc004cra.1_Silent_p.S157S	NM_001669	NP_001660	P51689	ARSD_HUMAN	arylsulfatase D isoform a precursor	157						lysosome	arylsulfatase activity|metal ion binding				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GATCCCCGCGGGATGCACAAT	0.557		NaN											0	0	0	0.004672	0	3	6									
APOO	79135	broad.mit.edu	37	X	23898967	23898967	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:23898967C>T	uc004dax.2	-	2	343	c.112G>A	c.(112-114)GAT>AAT	p.D38N	APOO_uc004daw.2_RNA|APOO_uc004day.3_RNA	NM_024122	NP_077027	Q9BUR5	APOO_HUMAN	apolipoprotein O precursor	38					lipid transport	high-density lipoprotein particle|integral to membrane|low-density lipoprotein particle|very-low-density lipoprotein particle					0						GTTACCTCATCAACCTTCACG	0.413		NaN											0	0	0	0.006214	0	10	35									
DCAF8L2	347442	broad.mit.edu	37	X	27766328	27766328	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:27766328C>G	uc011mjy.1	+	1	1403	c.1316C>G	c.(1315-1317)GCC>GGC	p.A439G		NM_001136533	NP_001130005			DDB1 and CUL4 associated factor 8-like 2											central_nervous_system(1)|pancreas(1)	2						GAGCTGCTAGCCAGCTACAAT	0.443		NaN											0	0	0	0.001882	0	21	37									
FAM47A	158724	broad.mit.edu	37	X	34149301	34149301	+	Silent	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:34149301C>T	uc004ddg.2	-	1	1128	c.1095G>A	c.(1093-1095)GCG>GCA	p.A365A		NM_203408	NP_981953	Q5JRC9	FA47A_HUMAN	hypothetical protein LOC158724	365										ovary(4)|central_nervous_system(1)	5						TCTTGGGAGGCGCTAGGCGGA	0.632		NaN											0	0	0	0.00245	0	15	26									
FAM47B	170062	broad.mit.edu	37	X	34962542	34962542	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:34962542C>T	uc004ddi.1	+	1	1612	c.1594C>T	c.(1594-1596)CGC>TGC	p.R532C		NM_152631	NP_689844	Q8NA70	FA47B_HUMAN	hypothetical protein LOC170062	532										ovary(3)|breast(1)	4						GGACAGGAGACGCCGGGCGGC	0.498		NaN											0	0	0	0.002445	0	32	74									
CXorf22	170063	broad.mit.edu	37	X	35974113	35974113	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:35974113G>A	uc004ddj.2	+	8	1269	c.1210G>A	c.(1210-1212)GGC>AGC	p.G404S	CXorf22_uc010ngv.2_RNA	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	404										large_intestine(1)|lung(1)|ovary(1)	3						AGCACTGACAGGCACAGGACT	0.363		NaN											0	0	0	0.00333	0	21	69									
SHROOM4	57477	broad.mit.edu	37	X	50339780	50339780	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:50339780C>G	uc004dpe.2	-	9	4423	c.4397G>C	c.(4396-4398)CGA>CCA	p.R1466P	SHROOM4_uc004dpd.3_RNA	NM_020717	NP_065768	Q9ULL8	SHRM4_HUMAN	shroom family member 4	1466	Potential.|ASD2.				actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)					CTCCAGCTCTCGCTGTTCAAT	0.502		NaN											0	0	0	0.005443	0	26	33									
SPANXN5	494197	broad.mit.edu	37	X	52825556	52825556	+	Nonsense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:52825556G>C	uc004drc.1	-	2	191	c.191C>G	c.(190-192)TCA>TGA	p.S64*		NM_001009616	NP_001009616	Q5MJ07	SPXN5_HUMAN	SPANX family, member N5	64											0	Ovarian(276;0.236)					CAGTTGATTTGAATGTATTTT	0.423		NaN											0	0	0	0.00623	0	37	95									
ITIH5L	347365	broad.mit.edu	37	X	54777522	54777522	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:54777522C>A	uc004dtj.2	-	12	3674	c.3644G>T	c.(3643-3645)AGG>ATG	p.R1215M		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	1215					hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						ACTGGGATGCCTGTAGCGGTG	0.627		NaN											1	0	3.59834e-05	0.001168	6.32513e-05	6	12									
FAM123B	139285	broad.mit.edu	37	X	63412575	63412575	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:63412575C>T	uc004dvo.2	-	2	865	c.592G>A	c.(592-594)GAG>AAG	p.E198K		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	198					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						CTGACCCTCTCAGGCCCCTTG	0.577		NaN											0	0	0	0.006122	0	18	71									
MTMR8	55613	broad.mit.edu	37	X	63488786	63488786	+	Silent	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:63488786C>G	uc004dvs.2	-	14	1814	c.1746G>C	c.(1744-1746)CTG>CTC	p.L582L	MTMR8_uc011mou.1_Intron	NM_017677	NP_060147	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	582						nuclear envelope	protein tyrosine phosphatase activity			ovary(2)|breast(2)	4						CATTCTCCATCAGGGTATTCA	0.483		NaN											0	0	0	0.00278	0	22	28									
ZMYM3	9203	broad.mit.edu	37	X	70471043	70471043	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:70471043C>G	uc004dzh.1	-	4	850	c.763G>C	c.(763-765)GAT>CAT	p.D255H	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Missense_Mutation_p.D255H|ZMYM3_uc004dzj.1_Missense_Mutation_p.D255H|ZMYM3_uc011mpu.1_5'UTR|ZMYM3_uc004dzk.3_Missense_Mutation_p.D255H|ZMYM3_uc004dzl.3_Missense_Mutation_p.D255H|ZMYM3_uc004dzm.3_Missense_Mutation_p.D255H	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	255					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					TCAGTGGAATCTACAACCTCA	0.537		NaN											0	0	0	0.006122	0	14	61									
ZMYM3	9203	broad.mit.edu	37	X	70471052	70471052	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:70471052C>T	uc004dzh.1	-	4	841	c.754G>A	c.(754-756)GAG>AAG	p.E252K	BCYRN1_uc011mpt.1_Intron|ZMYM3_uc004dzi.1_Missense_Mutation_p.E252K|ZMYM3_uc004dzj.1_Missense_Mutation_p.E252K|ZMYM3_uc011mpu.1_5'UTR|ZMYM3_uc004dzk.3_Missense_Mutation_p.E252K|ZMYM3_uc004dzl.3_Missense_Mutation_p.E252K|ZMYM3_uc004dzm.3_Missense_Mutation_p.E252K	NM_201599	NP_963893	Q14202	ZMYM3_HUMAN	zinc finger protein 261	252					multicellular organismal development	nucleus	DNA binding|zinc ion binding			ovary(1)	1	Renal(35;0.156)					TCTACAACCTCAGGTTTTGGA	0.532		NaN											0	0	0	0.008871	0	14	59									
OGT	8473	broad.mit.edu	37	X	70787373	70787373	+	Silent	SNP	T	T	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:70787373T>C	uc004eaa.1	+	20	2830	c.2613T>C	c.(2611-2613)AGT>AGC	p.S871S	BCYRN1_uc011mpt.1_Intron|OGT_uc004eab.1_Silent_p.S861S|OGT_uc004eac.2_Silent_p.S732S|OGT_uc004ead.2_Silent_p.S490S	NM_181672	NP_858058	O15294	OGT1_HUMAN	O-linked GlcNAc transferase isoform 1	871					cellular response to retinoic acid|positive regulation of granulocyte differentiation|positive regulation of histone H3-K4 methylation|positive regulation of proteolysis|protein O-linked glycosylation|signal transduction	cytosol|MLL5-L complex	enzyme activator activity|protein binding|protein N-acetylglucosaminyltransferase activity			ovary(3)|kidney(1)|pancreas(1)	5	Renal(35;0.156)					TTCCCAATAGTGTACTCTGGC	0.398		NaN											0	0	0	0.001523	0	19	43									
P2RY10	27334	broad.mit.edu	37	X	78216602	78216602	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:78216602G>T	uc004ede.2	+	4	954	c.585G>T	c.(583-585)TTG>TTT	p.L195F	P2RY10_uc004edf.2_Missense_Mutation_p.L195F	NM_014499	NP_055314	O00398	P2Y10_HUMAN	G-protein coupled purinergic receptor P2Y10	195	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(2)|lung(2)|breast(1)	5						CAGTTGCGTTGGTCGGGATGA	0.458		NaN											1	0	1.64113e-05	0.001523	2.89868e-05	22	61									
CPXCR1	53336	broad.mit.edu	37	X	88008581	88008581	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:88008581G>T	uc004efd.3	+	3	425	c.166G>T	c.(166-168)GCA>TCA	p.A56S	CPXCR1_uc004efc.3_Missense_Mutation_p.A56S	NM_033048	NP_149037	Q8N123	CPXCR_HUMAN	CPX chromosome region, candidate 1	56						intracellular	zinc ion binding			ovary(3)	3						GCCAGGCACAGCAACCTCCCA	0.453		NaN											1	0	8.12818e-05	0.001984	0.000142535	7	28									
PCDH11X	27328	broad.mit.edu	37	X	91873589	91873589	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:91873589C>T	uc004efk.1	+	7	4539	c.3694C>T	c.(3694-3696)CAC>TAC	p.H1232Y	PCDH11X_uc004efl.1_Missense_Mutation_p.H1222Y|PCDH11X_uc004efo.1_Missense_Mutation_p.H1195Y|PCDH11X_uc010nmv.1_3'UTR|PCDH11X_uc004efm.1_Missense_Mutation_p.H1224Y|PCDH11X_uc004efn.1_Missense_Mutation_p.H1214Y	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	1232	Cytoplasmic (Potential).				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						TACTGCACTTCACCACAGCCC	0.587		NaN											0	0	0	0.00623	0	39	94									
PCDH19	57526	broad.mit.edu	37	X	99663576	99663576	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:99663576G>A	uc010nmz.2	-	1	1696	c.20C>T	c.(19-21)CCG>CTG	p.P7L	PCDH19_uc004efw.3_Missense_Mutation_p.P7L|PCDH19_uc004efx.3_Missense_Mutation_p.P7L	NM_020766	NP_001098713	Q8TAB3	PCD19_HUMAN	protocadherin 19 isoform b	7					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)|breast(2)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	7						CAGCAGCACCGGCAGCAGGAG	0.682		NaN											0	0	0	0.000248	0	3	5									
TCEAL2	140597	broad.mit.edu	37	X	101382355	101382355	+	Missense_Mutation	SNP	A	A	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:101382355A>G	uc004eip.2	+	3	772	c.553A>G	c.(553-555)AAA>GAA	p.K185E		NM_080390	NP_525129	Q9H3H9	TCAL2_HUMAN	transcription elongation factor A (SII)-like 2	185					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						GAGAAAAAGCAAACAGAAATT	0.453		NaN											0	0	0	0.00361	0	49	143									
IRS4	8471	broad.mit.edu	37	X	107975913	107975913	+	Missense_Mutation	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:107975913C>T	uc004eoc.2	-	1	3695	c.3662G>A	c.(3661-3663)CGG>CAG	p.R1221Q		NM_003604	NP_003595	O14654	IRS4_HUMAN	insulin receptor substrate 4	1221						plasma membrane	insulin receptor binding|SH3/SH2 adaptor activity|signal transducer activity			ovary(4)|large_intestine(2)|lung(1)|breast(1)|skin(1)|pancreas(1)	10						TCTTGGCACCCGGCGACTGCG	0.592		NaN											0	0	0	0.00361	0	75	185									
NKAP	79576	broad.mit.edu	37	X	119077327	119077327	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:119077327C>G	uc004esh.2	-	1	409	c.242G>C	c.(241-243)AGA>ACA	p.R81T		NM_024528	NP_078804	Q8N5F7	NKAP_HUMAN	NFKB activating protein	81	Ser-rich.				negative regulation of transcription, DNA-dependent|Notch signaling pathway|positive regulation of alpha-beta T cell differentiation|transcription, DNA-dependent	cytoplasm|nucleus	chromatin binding|protein binding			ovary(2)	2						GGGCCGCTCTCTAGAACGCGA	0.662		NaN											0	0	0	0.004007	0	15	25									
GLUD2	2747	broad.mit.edu	37	X	120182792	120182792	+	Silent	SNP	G	G	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:120182792G>T	uc004eto.2	+	1	1331	c.1254G>T	c.(1252-1254)CTG>CTT	p.L418L		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2 precursor	418					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)	AGATCTTCCTGGAGAGAAACA	0.438		NaN											1	0	7.89702e-26	0.00361	1.50743e-25	57	187									
DCAF12L1	139170	broad.mit.edu	37	X	125685766	125685766	+	Nonsense_Mutation	SNP	C	C	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:125685766C>A	uc004eul.2	-	1	1077	c.826G>T	c.(826-828)GAA>TAA	p.E276*		NM_178470	NP_848565	Q5VU92	DC121_HUMAN	DDB1 and CUL4 associated factor 12-like 1	276	WD 3.									skin(3)|ovary(1)	4						GCTCCCAGTTCCTGGTTCTTG	0.637		NaN											1	0	0.00010058	0.001368	0.000175955	11	30									
BCORL1	63035	broad.mit.edu	37	X	129148662	129148662	+	Silent	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:129148662G>A	uc004evb.1	+	4	2028	c.1914G>A	c.(1912-1914)CAG>CAA	p.Q638Q	BCORL1_uc010nrd.1_Silent_p.Q540Q	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	638	Pro-rich.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						TGCCGAACCAGCGCAAGACAC	0.612		NaN											0	0	0	0.00632	0	28	65									
ZNF280C	55609	broad.mit.edu	37	X	129370577	129370577	+	Missense_Mutation	SNP	G	G	C			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:129370577G>C	uc004evm.2	-	7	684	c.530C>G	c.(529-531)TCT>TGT	p.S177C	ZNF280C_uc010nrf.1_Missense_Mutation_p.S177C	NM_017666	NP_060136	Q8ND82	Z280C_HUMAN	zinc finger protein 280C	177	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)	3						TTTAGAAGTAGAAGGATGTTT	0.318		NaN											0	0	0	0.007413	0	19	52									
BRS3	680	broad.mit.edu	37	X	135572431	135572431	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:135572431C>G	uc004ezv.1	+	2	723	c.574C>G	c.(574-576)CGA>GGA	p.R192G		NM_001727	NP_001718	P32247	BRS3_HUMAN	bombesin-like receptor 3	192	Extracellular (Potential).				adult feeding behavior|glucose metabolic process|regulation of blood pressure	integral to membrane|plasma membrane	bombesin receptor activity			ovary(1)	1	Acute lymphoblastic leukemia(192;0.000127)					ATACACTTTTCGAGATCCCAA	0.383		NaN											0	0	0	0.003755	0	37	54									
GPR50	9248	broad.mit.edu	37	X	150349467	150349467	+	Missense_Mutation	SNP	C	C	G			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:150349467C>G	uc010ntg.1	+	2	1547	c.1412C>G	c.(1411-1413)TCC>TGC	p.S471C		NM_004224	NP_004215	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	471	Cytoplasmic (Potential).|Pro-rich.				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AAGCCTGCTTCCAGCAACCCC	0.552		NaN											0	0	0	0.00361	0	138	288									
GPR50	9248	broad.mit.edu	37	X	150349531	150349531	+	Missense_Mutation	SNP	C	C	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:150349531C>A	uc010ntg.1	+	2	1611	c.1476C>A	c.(1474-1476)TTC>TTA	p.F492L		NM_004224	NP_004215	Q13585	MTR1L_HUMAN	G protein-coupled receptor 50	492	Cytoplasmic (Potential).|Pro-rich.				cell-cell signaling	integral to plasma membrane	melatonin receptor activity			large_intestine(1)|lung(1)|ovary(1)|pancreas(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					AGTCTGCCTTCAGTGCTGCCA	0.572		NaN											1	0	4.92795e-40	0.00361	9.50575e-40	87	196									
ATP2B3	492	broad.mit.edu	37	X	152818716	152818716	+	Missense_Mutation	SNP	G	G	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:152818716G>T	uc004fht.1	+	11	2173	c.2047G>T	c.(2047-2049)GTG>TTG	p.V683L	ATP2B3_uc004fhs.1_Missense_Mutation_p.V683L	NM_001001344	NP_001001344	Q16720	AT2B3_HUMAN	plasma membrane calcium ATPase 3 isoform 3b	683	Cytoplasmic (Potential).				ATP biosynthetic process|platelet activation	integral to membrane|plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding			pancreas(1)	1	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					TGAGGACCCTGTGCGGCCCGA	0.632		NaN											1	0	0.000219431	0.00245	0.000381145	13	27									
SRPK3	26576	broad.mit.edu	37	X	153048313	153048313	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:153048313G>A	uc004fil.2	+	6	594	c.562G>A	c.(562-564)GTG>ATG	p.V188M	SRPK3_uc004fik.2_Missense_Mutation_p.V254M|SRPK3_uc010nul.2_Missense_Mutation_p.V146M|SRPK3_uc004fin.2_Missense_Mutation_p.V188M|SRPK3_uc004fim.2_Missense_Mutation_p.V188M	NM_014370	NP_055185	Q9UPE1	SRPK3_HUMAN	serine arginine rich protein-specific kinase 3	188	Protein kinase.				cell differentiation|muscle organ development|muscle tissue development		ATP binding|protein serine/threonine kinase activity			pancreas(2)|lung(1)	3	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					CGTGCCCTGCGTGAAGAGCAT	0.642		NaN											0	0	0	0.00245	0	14	20									
FLNA	2316	broad.mit.edu	37	X	153578566	153578566	+	Missense_Mutation	SNP	G	G	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:153578566G>A	uc004fkk.2	-	45	7415	c.7166C>T	c.(7165-7167)GCT>GTT	p.A2389V	FLNA_uc004fki.2_Missense_Mutation_p.A432V|FLNA_uc011mzn.1_Missense_Mutation_p.A522V|FLNA_uc010nuu.1_Missense_Mutation_p.A2381V	NM_001110556	NP_001104026	P21333	FLNA_HUMAN	filamin A, alpha isoform 2	2389	Filamin 22.				actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GAAGCGCACAGCATACTTATC	0.582		NaN											0	0	0	0.003954	0	23	58									
CTAG2	30848	broad.mit.edu	37	X	153880854	153880854	+	Silent	SNP	C	C	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:153880854C>T	uc004fmi.1	-	2	374	c.321G>A	c.(319-321)AGG>AGA	p.R107R	CTAG2_uc004fmh.1_Silent_p.R107R	NM_020994	NP_066274	O75638	CTAG2_HUMAN	cancer/testis antigen 2 isoform LAGE-1b	107						centrosome				pancreas(1)	1	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GGGACAGGATCCTGCGGACCA	0.622		NaN											0	0	0	0.001523	0	18	35									
CAMSAP1L1	23271	broad.mit.edu	37	1	200709041	200709062	+	Frame_Shift_Del	DEL	GGGCCAAAATCGCCTGCAATCT	GGGCCAAAATCGCCTGCAATCT	-			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr1:200709041_200709062delGGGCCAAAATCGCCTGCAATCT	uc001gvl.2	+	1	356_377	c.86_107delGGGCCAAAATCGCCTGCAATCT	c.(85-108)AGGGCCAAAATCGCCTGCAATCTGfs	p.R29fs	CAMSAP1L1_uc001gvk.2_Frame_Shift_Del_p.R29fs|CAMSAP1L1_uc001gvm.2_Frame_Shift_Del_p.R29fs	NM_203459	NP_982284	Q08AD1	CAMP2_HUMAN	calmodulin regulated spectrin-associated protein	29_36						cytoplasm|microtubule	protein binding			ovary(2)|large_intestine(1)|pancreas(1)	4						GATTTCTCCAGGGCCAAAATCGCCTGCAATCTGGCCTGGCTG	0.55		NaN											NaN	NaN	NaN	NaN	NaN	8	71	---	---							
ANKRD36	375248	broad.mit.edu	37	2	97875579	97875580	+	Frame_Shift_Ins	INS	-	-	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr2:97875579_97875580insA	uc010yva.1	+	56	3581_3582	c.3337_3338insA	c.(3337-3339)GAAfs	p.E1113fs		NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	1113											0						TATAGCCAGAGAAAAAAAGGAT	0.317		NaN											NaN	NaN	NaN	NaN	NaN	4	6	---	---							
SAMHD1	25939	broad.mit.edu	37	20	35533895	35533896	+	Frame_Shift_Ins	INS	-	-	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr20:35533895_35533896insA	uc002xgh.1	-	12	1411_1412	c.1281_1282insT	c.(1279-1284)TTTCTGfs	p.F427fs	SAMHD1_uc010gft.1_RNA	NM_015474	NP_056289	Q9Y3Z3	SAMH1_HUMAN	SAM domain- and HD domain-containing protein 1	427_428					defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity				0		Myeloproliferative disorder(115;0.00878)				AAAATCTCCAGAAAAATGTTAT	0.292		NaN											NaN	NaN	NaN	NaN	NaN	41	63	---	---							
CCNL1	57018	broad.mit.edu	37	3	156877198	156877198	+	Frame_Shift_Del	DEL	A	A	-			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr3:156877198delA	uc003fbf.2	-	2	973	c.374delT	c.(373-375)TTCfs	p.F125fs	CCNL1_uc003fbd.1_Frame_Shift_Del_p.F125fs|CCNL1_uc003fbg.2_RNA|CCNL1_uc011bor.1_RNA|CCNL1_uc003fbi.1_5'UTR	NM_020307	NP_064703	Q9UK58	CCNL1_HUMAN	cyclin L1	125	Cyclin-like 1.				regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nuclear speck	protein kinase binding			lung(3)|breast(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(72;0.0295)|Lung(72;0.0308)			GCTTACCTCGAAACTGTGTTT	0.517		NaN											NaN	NaN	NaN	NaN	NaN	17	50	---	---							
ZDHHC19	131540	broad.mit.edu	37	3	195925257	195925257	+	Frame_Shift_Del	DEL	A	A	-			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr3:195925257delA	uc003fwc.2	-	7	953	c.839delT	c.(838-840)CTGfs	p.L280fs	ZDHHC19_uc010hzz.2_RNA|ZDHHC19_uc010iaa.2_RNA|ZDHHC19_uc010iab.2_Intron	NM_001039617	NP_001034706	Q8WVZ1	ZDH19_HUMAN	zinc finger, DHHC domain containing 19	280						integral to membrane	acyltransferase activity|zinc ion binding			ovary(3)	3	all_cancers(143;1.68e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.89e-25)|all cancers(36;1.46e-23)|OV - Ovarian serous cystadenocarcinoma(49;2.1e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.0022)		TGGAGGGTGCAGATTCGGCAT	0.652		NaN											NaN	NaN	NaN	NaN	NaN	12	58	---	---							
ATP10D	57205	broad.mit.edu	37	4	47538490	47538491	+	Frame_Shift_Ins	INS	-	-	T			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr4:47538490_47538491insT	uc003gxk.1	+	8	1216_1217	c.1052_1053insT	c.(1051-1053)CATfs	p.H351fs	ATP10D_uc003gxl.1_5'UTR|ATP10D_uc003gxj.3_Frame_Shift_Ins_p.H351fs	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	351	Extracellular (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						GAAAAGATGCATTTTTTCAATG	0.342		NaN											NaN	NaN	NaN	NaN	NaN	112	80	---	---							
EYA4	2070	broad.mit.edu	37	6	133783839	133783839	+	Frame_Shift_Del	DEL	A	A	-			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr6:133783839delA	uc003qec.3	+	9	1119	c.661delA	c.(661-663)AGTfs	p.S221fs	EYA4_uc011ecq.1_Frame_Shift_Del_p.S167fs|EYA4_uc011ecr.1_Frame_Shift_Del_p.S167fs|EYA4_uc003qed.3_Frame_Shift_Del_p.S221fs|EYA4_uc003qee.3_Frame_Shift_Del_p.S198fs|EYA4_uc011ecs.1_Frame_Shift_Del_p.S221fs|uc003qef.1_Intron	NM_004100	NP_004091	O95677	EYA4_HUMAN	eyes absent 4 isoform a	221					anatomical structure morphogenesis|chromatin modification|DNA repair|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent|visual perception	cytoplasm|nucleus	metal ion binding|protein tyrosine phosphatase activity			large_intestine(2)	2	Colorectal(23;0.221)			GBM - Glioblastoma multiforme(68;0.00457)|OV - Ovarian serous cystadenocarcinoma(155;0.0152)		TGGCTGCCTCAGTTACAGCCC	0.473		NaN											NaN	NaN	NaN	NaN	NaN	23	37	---	---							
GLIS3	169792	broad.mit.edu	37	9	4117765	4117766	+	Splice_Site	INS	-	-	A			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chr9:4117765_4117766insA	uc003zhw.1	-	3	1439	c.1245_splice	c.e3+1	p.T415_splice	GLIS3_uc003zhx.1_Splice_Site_p.T570_splice|GLIS3_uc003zhy.1_Intron|GLIS3_uc003zhz.1_Intron	NM_152629	NP_689842	Q8NEA6	GLIS3_HUMAN	GLIS family zinc finger 3 isoform b						negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|transcription from RNA polymerase II promoter		DNA binding|zinc ion binding			ovary(1)	1		Acute lymphoblastic leukemia(2;0.00464)|Breast(48;0.148)		Lung(2;0.00163)|GBM - Glioblastoma multiforme(50;0.00301)|LUSC - Lung squamous cell carcinoma(2;0.0148)		TTCGGAAACTCACCGTACACTT	0.559		NaN											NaN	NaN	NaN	NaN	NaN	70	76	---	---							
GLUD2	2747	broad.mit.edu	37	X	120182413	120182413	+	Frame_Shift_Del	DEL	T	T	-			TCGA-G2-A2EJ-01A-11D-A17V-08	TCGA-G2-A2EJ-10A-01D-A17V-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	82f98ff9-7161-45c3-8107-033b47e25f21	faac4243-dcb7-4fe7-974f-7c1c97c101b3	g.chrX:120182413delT	uc004eto.2	+	1	952	c.875delT	c.(874-876)ATTfs	p.I292fs		NM_012084	NP_036216	P49448	DHE4_HUMAN	glutamate dehydrogenase 2 precursor	292					glutamate biosynthetic process|glutamate catabolic process	mitochondrial matrix	ADP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|leucine binding			pancreas(1)	1					L-Glutamic Acid(DB00142)|NADH(DB00157)	TACATGAGCATTTTAGGAATG	0.438		NaN											NaN	NaN	NaN	NaN	NaN	36	108	---	---							
