Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	filter
CCDC27	148870	broad.mit.edu	37	1	3670758	3670758	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr1:3670758C>A	uc001akv.2	+	2	476	c.395C>A	c.(394-396)CCT>CAT	p.P132H		NM_152492	NP_689705	Q2M243	CCD27_HUMAN	coiled-coil domain containing 27	132										skin(1)	1	all_cancers(77;0.0385)|Ovarian(185;0.0634)|Lung NSC(156;0.21)|all_lung(157;0.218)	all_epithelial(116;5.52e-17)|all_lung(118;1.04e-06)|Lung NSC(185;0.000214)|Renal(390;0.00357)|Breast(487;0.00446)|Hepatocellular(190;0.0218)|Lung SC(97;0.0367)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.127)		Epithelial(90;1.11e-38)|OV - Ovarian serous cystadenocarcinoma(86;1.35e-22)|GBM - Glioblastoma multiforme(42;3.46e-16)|Colorectal(212;1.17e-05)|COAD - Colon adenocarcinoma(227;5.76e-05)|Kidney(185;0.00036)|BRCA - Breast invasive adenocarcinoma(365;0.000696)|KIRC - Kidney renal clear cell carcinoma(229;0.00558)|STAD - Stomach adenocarcinoma(132;0.00645)|Lung(427;0.203)		CCCACGCATCCTGACTGCCCC	0.602													93	94	---	---	---	---	PASS
PIK3CD	5293	broad.mit.edu	37	1	9782144	9782144	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr1:9782144G>A	uc001aqb.3	+	17	2375	c.2167G>A	c.(2167-2169)GCC>ACC	p.A723T	PIK3CD_uc010oaf.1_Missense_Mutation_p.A722T|PIK3CD_uc001aqe.3_Missense_Mutation_p.A747T	NM_005026	NP_005017	O00329	PK3CD_HUMAN	catalytic phosphatidylinositol 3-kinase delta	723					phosphatidylinositol-mediated signaling|protein phosphorylation	phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(4)|skin(2)|central_nervous_system(1)	7	all_lung(157;0.222)	all_lung(118;2.44e-05)|Lung NSC(185;4.08e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00314)|Hepatocellular(190;0.00825)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0231)|Colorectal(212;7.52e-08)|COAD - Colon adenocarcinoma(227;1.78e-05)|Kidney(185;0.000322)|KIRC - Kidney renal clear cell carcinoma(229;0.00114)|BRCA - Breast invasive adenocarcinoma(304;0.0021)|STAD - Stomach adenocarcinoma(132;0.00395)|READ - Rectum adenocarcinoma(331;0.0419)		GCGGCAGGAGGCCTACCTAGA	0.622											OREG0013082	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	40	---	---	---	---	PASS
PTCHD2	57540	broad.mit.edu	37	1	11562836	11562836	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr1:11562836C>A	uc001ash.3	+	3	1336	c.1198C>A	c.(1198-1200)CTG>ATG	p.L400M	PTCHD2_uc001asi.1_Missense_Mutation_p.L400M	NM_020780	NP_065831	Q9P2K9	PTHD2_HUMAN	patched domain containing 2	400	Extracellular (Potential).				cholesterol homeostasis|regulation of lipid transport|smoothened signaling pathway	endoplasmic reticulum|integral to membrane|nuclear membrane	hedgehog receptor activity			skin(3)|ovary(2)|pancreas(1)|breast(1)	7	Ovarian(185;0.249)	Lung NSC(185;4.16e-05)|all_lung(284;4.76e-05)|Renal(390;0.000147)|Breast(348;0.00093)|Colorectal(325;0.00205)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.13e-07)|COAD - Colon adenocarcinoma(227;4.83e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000325)|Kidney(185;0.000877)|KIRC - Kidney renal clear cell carcinoma(229;0.00273)|STAD - Stomach adenocarcinoma(313;0.00766)|READ - Rectum adenocarcinoma(331;0.0549)		CAGTGAGATCCTGTTTGGAGC	0.562													47	38	---	---	---	---	PASS
ARID1A	8289	broad.mit.edu	37	1	27106599	27106599	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr1:27106599G>T	uc001bmv.1	+	20	6583	c.6210G>T	c.(6208-6210)CAG>CAT	p.Q2070H	ARID1A_uc001bmu.1_Missense_Mutation_p.Q1853H|ARID1A_uc001bmx.1_Missense_Mutation_p.Q916H|ARID1A_uc009vsm.1_Missense_Mutation_p.Q398H|ARID1A_uc009vsn.1_Missense_Mutation_p.Q312H	NM_006015	NP_006006	O14497	ARI1A_HUMAN	AT rich interactive domain 1A isoform a	2070					androgen receptor signaling pathway|chromatin-mediated maintenance of transcription|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|nervous system development|nucleosome mobilization|transcription, DNA-dependent	nBAF complex|npBAF complex|SWI/SNF complex	DNA binding|protein binding			ovary(124)|pancreas(5)|central_nervous_system(3)|endometrium(3)|kidney(3)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	142		all_cancers(24;6.36e-27)|all_epithelial(13;5.93e-24)|Colorectal(325;3.46e-05)|all_lung(284;4.76e-05)|Lung NSC(340;5.83e-05)|Breast(348;9.7e-05)|Renal(390;0.0007)|Ovarian(437;0.00473)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0178)|all cancers(4;2.61e-56)|Epithelial(14;7.53e-55)|OV - Ovarian serous cystadenocarcinoma(117;4.5e-30)|Colorectal(126;2.07e-09)|COAD - Colon adenocarcinoma(152;4.29e-07)|BRCA - Breast invasive adenocarcinoma(304;4.13e-05)|STAD - Stomach adenocarcinoma(196;0.000279)|KIRC - Kidney renal clear cell carcinoma(1967;0.000794)|GBM - Glioblastoma multiforme(114;0.0132)|READ - Rectum adenocarcinoma(331;0.0469)|Lung(427;0.167)|LUSC - Lung squamous cell carcinoma(448;0.242)		TCTCGGGGCAGTTGGACCTAT	0.572			Mis|N|F|S|D		clear cell ovarian carcinoma|RCC								57	52	---	---	---	---	PASS
KIAA0494	9813	broad.mit.edu	37	1	47150268	47150268	+	Missense_Mutation	SNP	C	G	G			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr1:47150268C>G	uc001cqk.3	-	9	2058	c.1081G>C	c.(1081-1083)GAT>CAT	p.D361H	KIAA0494_uc010omh.1_Missense_Mutation_p.D297H|KIAA0494_uc010omj.1_Missense_Mutation_p.D153H|KIAA0494_uc001cql.1_Missense_Mutation_p.D361H	NM_014774	NP_055589	O75071	K0494_HUMAN	hypothetical protein LOC9813	361							calcium ion binding				0	Acute lymphoblastic leukemia(166;0.155)					TTTGAACTATCTTCTTTCTGC	0.343													3	86	---	---	---	---	PASS
ASB17	127247	broad.mit.edu	37	1	76397808	76397808	+	Missense_Mutation	SNP	A	G	G			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr1:76397808A>G	uc001dhe.1	-	1	309	c.169T>C	c.(169-171)TAT>CAT	p.Y57H	ASB17_uc001dhf.1_RNA	NM_080868	NP_543144	Q8WXJ9	ASB17_HUMAN	ankyrin repeat and SOCS box-containing 17	57					intracellular signal transduction					ovary(1)	1						AAGTCCACATACCTCAGAATT	0.398													50	36	---	---	---	---	PASS
LPAR3	23566	broad.mit.edu	37	1	85331494	85331494	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr1:85331494G>A	uc001dkl.2	-	1	349	c.310C>T	c.(310-312)CTC>TTC	p.L104F	LPAR3_uc009wcj.1_Missense_Mutation_p.L104F	NM_012152	NP_036284	Q9UBY5	LPAR3_HUMAN	lysophosphatidic acid receptor 3	104	Helical; Name=3; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|synaptic transmission	integral to plasma membrane|intracellular membrane-bounded organelle				lung(3)|ovary(2)	5						CCCTGACGGAGAAACCAGCGG	0.493													110	85	---	---	---	---	PASS
EVI5	7813	broad.mit.edu	37	1	93163484	93163484	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr1:93163484C>A	uc001dox.2	-	6	840	c.830G>T	c.(829-831)CGT>CTT	p.R277L	EVI5_uc010otf.1_Missense_Mutation_p.R277L	NM_005665	NP_005656	O60447	EVI5_HUMAN	ecotropic viral integration site 5	277	Dimerization.|Interaction with alpha-tubulin, gamma- tubulin, BIRC5 and FBXO5.|Rab-GAP TBC.				cell cycle|cell division|cell proliferation|multicellular organismal development	microtubule organizing center|nucleus|spindle	protein binding|Rab GTPase activator activity			ovary(1)|breast(1)	2		all_lung(203;0.00146)|Lung NSC(277;0.00565)|all_neural(321;0.185)|Melanoma(281;0.193)|Glioma(108;0.203)		Epithelial(280;8.09e-25)|OV - Ovarian serous cystadenocarcinoma(397;1.27e-22)|all cancers(265;1.74e-21)|GBM - Glioblastoma multiforme(16;0.00233)|BRCA - Breast invasive adenocarcinoma(282;0.211)		AAAAAGTTCACGAAGTCTATA	0.328													76	58	---	---	---	---	PASS
NUP210L	91181	broad.mit.edu	37	1	154067592	154067592	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr1:154067592G>T	uc001fdw.2	-	15	2078	c.2006C>A	c.(2005-2007)TCT>TAT	p.S669Y	NUP210L_uc009woq.2_Translation_Start_Site|NUP210L_uc010peh.1_Missense_Mutation_p.S669Y	NM_207308	NP_997191	Q5VU65	P210L_HUMAN	nucleoporin 210kDa-like isoform 1	669						integral to membrane				skin(5)|ovary(4)|large_intestine(1)|central_nervous_system(1)	11	all_lung(78;9.35e-31)|Lung NSC(65;1.33e-28)|Hepatocellular(266;0.0877)|Melanoma(130;0.128)		LUSC - Lung squamous cell carcinoma(543;0.151)|Colorectal(543;0.198)			TTCCTTCACAGACTGCCATGT	0.403													18	83	---	---	---	---	PASS
HDGF	3068	broad.mit.edu	37	1	156713634	156713634	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr1:156713634C>T	uc001fpy.3	-	5	848	c.526G>A	c.(526-528)GAA>AAA	p.E176K	MRPL24_uc001fpw.1_5'Flank|MRPL24_uc001fpx.1_5'Flank|HDGF_uc009wsd.2_Missense_Mutation_p.E144K|HDGF_uc001fpz.3_Missense_Mutation_p.E169K|HDGF_uc009wse.2_Missense_Mutation_p.E192K|HDGF_uc010phr.1_Missense_Mutation_p.E199K|HDGF_uc009wsf.2_Missense_Mutation_p.E144K|HDGF_uc009wsg.2_Missense_Mutation_p.E176K	NM_004494	NP_004485	P51858	HDGF_HUMAN	hepatoma-derived growth factor isoform a	176	Glu-rich.				cell proliferation|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|extracellular space|nucleus	DNA binding|growth factor activity|heparin binding|nucleotide binding			lung(1)	1	all_hematologic(923;0.088)|Hepatocellular(266;0.158)	Breast(1374;0.198)		Colorectal(1306;0.018)		TCCTCTCCTTCAGGGTTTTCT	0.612													6	97	---	---	---	---	PASS
OR10R2	343406	broad.mit.edu	37	1	158450081	158450081	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr1:158450081G>T	uc010pik.1	+	1	414	c.414G>T	c.(412-414)ATG>ATT	p.M138I	uc001fso.1_RNA	NM_001004472	NP_001004472	Q8NGX6	O10R2_HUMAN	olfactory receptor, family 10, subfamily R,	138	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			pancreas(2)|skin(1)	3	all_hematologic(112;0.0378)					TGGGTGTGATGGGTTATGATC	0.483													74	495	---	---	---	---	PASS
PAPPA2	60676	broad.mit.edu	37	1	176679237	176679237	+	Silent	SNP	T	G	G			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr1:176679237T>G	uc001gkz.2	+	11	4740	c.3576T>G	c.(3574-3576)GCT>GCG	p.A1192A	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1192					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						ATCAATGGGCTACCCGGGCTT	0.443													96	61	---	---	---	---	PASS
RASAL2	9462	broad.mit.edu	37	1	178427316	178427316	+	Silent	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr1:178427316G>A	uc001glr.2	+	12	2591	c.2466G>A	c.(2464-2466)AAG>AAA	p.K822K	RASAL2_uc001glq.2_Silent_p.K963K|RASAL2_uc009wxc.2_Silent_p.K336K	NM_004841	NP_004832	Q9UJF2	NGAP_HUMAN	RAS protein activator like 2 isoform 1	822					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity			ovary(2)|breast(2)|large_intestine(1)	5						AAGACTTCAAGCTCAGTGGAC	0.483													80	76	---	---	---	---	PASS
CACNA1S	779	broad.mit.edu	37	1	201047035	201047035	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr1:201047035G>A	uc001gvv.2	-	11	1818	c.1591C>T	c.(1591-1593)CGC>TGC	p.R531C		NM_000069	NP_000060	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type,	531	II.|Helical; Name=S4 of repeat II; (Potential).				axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			ovary(3)|central_nervous_system(1)|skin(1)	5					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	CTCAGGAGGCGGATGCAGCGG	0.647													4	68	---	---	---	---	PASS
FAIM3	9214	broad.mit.edu	37	1	207087143	207087143	+	Silent	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr1:207087143G>T	uc001hey.2	-	2	513	c.334C>A	c.(334-336)CGG>AGG	p.R112R	FAIM3_uc010prz.1_Intron|FAIM3_uc010psa.1_Intron|FAIM3_uc010psb.1_Silent_p.R112R	NM_005449	NP_005440	O60667	FAIM3_HUMAN	Fas apoptotic inhibitory molecule 3 isoform a	112	Extracellular (Potential).				anti-apoptosis|cellular defense response	integral to membrane				central_nervous_system(1)	1	Breast(84;0.201)					GTCTTTCCCCGGTCTGTGTTC	0.517													73	89	---	---	---	---	PASS
RYR2	6262	broad.mit.edu	37	1	237532900	237532900	+	Missense_Mutation	SNP	A	G	G			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr1:237532900A>G	uc001hyl.1	+	6	496	c.376A>G	c.(376-378)AGT>GGT	p.S126G		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	126	Cytoplasmic (By similarity).|MIR 1.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			CCATTCCTATAGTGGCATGGT	0.413													5	4	---	---	---	---	PASS
RYR2	6262	broad.mit.edu	37	1	237936851	237936851	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr1:237936851C>A	uc001hyl.1	+	87	11798	c.11678C>A	c.(11677-11679)TCT>TAT	p.S3893Y	RYR2_uc010pya.1_Missense_Mutation_p.S308Y	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3893					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TGGTATTACTCTGGGAAAGAT	0.333													18	69	---	---	---	---	PASS
MAP1LC3C	440738	broad.mit.edu	37	1	242159552	242159552	+	Silent	SNP	G	A	A	rs147920150	byFrequency	TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr1:242159552G>A	uc001hzk.2	-	4	432	c.357C>T	c.(355-357)TAC>TAT	p.Y119Y		NM_001004343	NP_001004343	Q9BXW4	MLP3C_HUMAN	microtubule-associated protein 1 light chain 3	119					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|endomembrane system|microtubule	protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(106;0.0188)			CCTGGGAGGCGTAGGTCATGT	0.562													6	176	---	---	---	---	PASS
OR2M2	391194	broad.mit.edu	37	1	248343796	248343796	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr1:248343796G>T	uc010pzf.1	+	1	509	c.509G>T	c.(508-510)GGG>GTG	p.G170V		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	170	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			TCCTTTTGTGGGTCTCGGGAA	0.423													98	314	---	---	---	---	PASS
OR2M2	391194	broad.mit.edu	37	1	248343797	248343797	+	Silent	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr1:248343797G>T	uc010pzf.1	+	1	510	c.510G>T	c.(508-510)GGG>GGT	p.G170G		NM_001004688	NP_001004688	Q96R28	OR2M2_HUMAN	olfactory receptor, family 2, subfamily M,	170	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|skin(1)	4	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0245)			CCTTTTGTGGGTCTCGGGAAA	0.423													96	315	---	---	---	---	PASS
LHCGR	3973	broad.mit.edu	37	2	48915452	48915452	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr2:48915452G>A	uc002rwu.3	-	11	1554	c.1484C>T	c.(1483-1485)TCT>TTT	p.S495F	GTF2A1L_uc002rwt.2_Intron	NM_000233	NP_000224	P22888	LSHR_HUMAN	luteinizing hormone/choriogonadotropin receptor	495	Helical; Name=4; (Potential).				male genitalia development|male gonad development	endosome|integral to plasma membrane	luteinizing hormone receptor activity			ovary(3)|lung(2)|breast(2)|skin(1)	8		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.176)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Cetrorelix(DB00050)|Choriogonadotropin alfa(DB00097)|Goserelin(DB00014)|Lutropin alfa(DB00044)|Menotropins(DB00032)	AGCAATTAGAGAAGAAAAGAG	0.438									Familial_Male-Limited_Precocious_Puberty				64	64	---	---	---	---	PASS
DYSF	8291	broad.mit.edu	37	2	71886131	71886131	+	Missense_Mutation	SNP	T	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr2:71886131T>C	uc002sie.2	+	43	5138	c.4762T>C	c.(4762-4764)TTT>CTT	p.F1588L	DYSF_uc010feg.2_Missense_Mutation_p.F1619L|DYSF_uc010feh.2_Missense_Mutation_p.F1595L|DYSF_uc002sig.3_Missense_Mutation_p.F1574L|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.F1609L|DYSF_uc010fef.2_Missense_Mutation_p.F1626L|DYSF_uc010fei.2_Missense_Mutation_p.F1605L|DYSF_uc010fek.2_Missense_Mutation_p.F1606L|DYSF_uc010fej.2_Missense_Mutation_p.F1596L|DYSF_uc010fel.2_Missense_Mutation_p.F1575L|DYSF_uc010feo.2_Missense_Mutation_p.F1620L|DYSF_uc010fem.2_Missense_Mutation_p.F1610L|DYSF_uc010fen.2_Missense_Mutation_p.F1627L|DYSF_uc002sif.2_Missense_Mutation_p.F1589L|DYSF_uc010yqy.1_Missense_Mutation_p.F469L|DYSF_uc010yqz.1_Missense_Mutation_p.F349L	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	1588	Cytoplasmic (Potential).|C2 5.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						TGTCCGAGCATTTGGCCTGCA	0.592													21	144	---	---	---	---	PASS
REG1B	5968	broad.mit.edu	37	2	79313940	79313940	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr2:79313940C>A	uc002sny.2	-	3	293	c.181G>T	c.(181-183)GAT>TAT	p.D61Y	REG1B_uc010ffv.1_Missense_Mutation_p.D61Y|REG1B_uc010ffw.2_Missense_Mutation_p.D61Y	NM_006507	NP_006498	P48304	REG1B_HUMAN	regenerating islet-derived 1 beta precursor	61	C-type lectin.				cell proliferation	extracellular region	sugar binding			central_nervous_system(1)|skin(1)	2						TCACTCACATCTGCATCAACC	0.507													48	142	---	---	---	---	PASS
Unknown	0	broad.mit.edu	37	2	89475835	89475835	+	RNA	SNP	A	G	G			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr2:89475835A>G	uc010ytr.1	-	28		c.3646T>C			uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																		GCTTGCATGCAGTAATAAACC	0.522													83	42	---	---	---	---	PASS
TEKT4	150483	broad.mit.edu	37	2	95539813	95539813	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr2:95539813G>A	uc002stw.1	+	3	766	c.673G>A	c.(673-675)GAG>AAG	p.E225K	uc002stv.1_Intron|TEKT4_uc010fhr.1_RNA	NM_144705	NP_653306	Q8WW24	TEKT4_HUMAN	tektin 4	225					cell projection organization|microtubule cytoskeleton organization	cilium axoneme|flagellar axoneme|microtubule				ovary(1)|breast(1)|skin(1)	3						CCAGAGCACCGAGGTGCAGGC	0.642													61	54	---	---	---	---	PASS
ACTR1B	10120	broad.mit.edu	37	2	98275028	98275028	+	Silent	SNP	G	C	C	rs147014229		TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr2:98275028G>C	uc002syb.2	-	6	727	c.519C>G	c.(517-519)GGC>GGG	p.G173G		NM_005735	NP_005726	P42025	ACTY_HUMAN	ARP1 actin-related protein 1 homolog B,	173						centrosome|dynactin complex	ATP binding|protein binding			skin(1)	1						GCATGGCAAAGCCCTCATAGA	0.607													5	212	---	---	---	---	PASS
REV1	51455	broad.mit.edu	37	2	100065857	100065857	+	Missense_Mutation	SNP	A	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr2:100065857A>T	uc002tad.2	-	4	503	c.291T>A	c.(289-291)AAT>AAA	p.N97K	REV1_uc002tac.2_Missense_Mutation_p.N97K|REV1_uc002tae.1_Missense_Mutation_p.N76K	NM_016316	NP_057400	Q9UBZ9	REV1_HUMAN	REV1-like isoform 1	97	BRCT.				DNA replication|error-prone translesion synthesis|response to UV	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|magnesium ion binding|protein binding			ovary(2)	2						TAATTTTGGCATTGGGAAGAT	0.289								DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					150	105	---	---	---	---	PASS
AFF3	3899	broad.mit.edu	37	2	100203674	100203674	+	Missense_Mutation	SNP	G	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr2:100203674G>C	uc002tag.2	-	15	2769	c.2533C>G	c.(2533-2535)CTG>GTG	p.L845V	AFF3_uc002taf.2_Missense_Mutation_p.L870V|AFF3_uc010fiq.1_Missense_Mutation_p.L845V|AFF3_uc010yvr.1_Missense_Mutation_p.L998V|AFF3_uc002tah.1_Missense_Mutation_p.L870V	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	845					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						GAGGTGGCCAGTCTTGAAGAG	0.473													77	315	---	---	---	---	PASS
IL1R2	7850	broad.mit.edu	37	2	102636197	102636197	+	Missense_Mutation	SNP	A	G	G			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr2:102636197A>G	uc002tbm.2	+	5	840	c.611A>G	c.(610-612)TAT>TGT	p.Y204C	IL1R2_uc002tbn.2_Missense_Mutation_p.Y204C|IL1R2_uc002tbo.1_Missense_Mutation_p.Y204C	NM_004633	NP_004624	P27930	IL1R2_HUMAN	interleukin 1 receptor, type II precursor	204	Extracellular (Potential).|Ig-like C2-type 2.				immune response	integral to membrane|plasma membrane	interleukin-1, Type II, blocking receptor activity			ovary(1)|breast(1)	2					Anakinra(DB00026)	GATGCTGGCTATTACCGCTGT	0.458													15	80	---	---	---	---	PASS
SLC35F5	80255	broad.mit.edu	37	2	114512814	114512814	+	Silent	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr2:114512814C>T	uc002tku.1	-	3	625	c.201G>A	c.(199-201)AGG>AGA	p.R67R	SLC35F5_uc002tkt.2_RNA|SLC35F5_uc002tkv.2_Silent_p.R61R|SLC35F5_uc002tkw.2_Silent_p.R67R	NM_025181	NP_079457	Q8WV83	S35F5_HUMAN	solute carrier family 35, member F5	67					transport	integral to membrane					0						GAGCCATTCGCCTGCGCTGAG	0.413													22	84	---	---	---	---	PASS
GYPC	2995	broad.mit.edu	37	2	127447886	127447886	+	Silent	SNP	A	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr2:127447886A>C	uc002tnq.2	+	2	261	c.105A>C	c.(103-105)GCA>GCC	p.A35A	GYPC_uc002tnr.2_Intron|GYPC_uc010flv.2_RNA	NM_002101	NP_002092	P04921	GLPC_HUMAN	glycophorin C isoform 1	35	Extracellular.					cortical cytoskeleton|integral to plasma membrane	protein binding			central_nervous_system(1)	1	Colorectal(110;0.0533)			BRCA - Breast invasive adenocarcinoma(221;0.075)		CCACCATTGCAGGTGAGTTCT	0.527													62	30	---	---	---	---	PASS
NCKAP5	344148	broad.mit.edu	37	2	133489454	133489454	+	Nonsense_Mutation	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr2:133489454G>A	uc002ttp.2	-	17	5673	c.5299C>T	c.(5299-5301)CAA>TAA	p.Q1767*	NCKAP5_uc002ttq.2_Nonsense_Mutation_p.Q448*	NM_207363	NP_997246	O14513	NCKP5_HUMAN	Nck-associated protein 5 isoform 1	1767							protein binding				0						TCAAGGGTTTGGGCTCTCATG	0.592													51	51	---	---	---	---	PASS
SLC4A10	57282	broad.mit.edu	37	2	162751258	162751258	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr2:162751258G>A	uc002ubx.3	+	11	1448	c.1264G>A	c.(1264-1266)GAT>AAT	p.D422N	SLC4A10_uc010fpa.1_Missense_Mutation_p.D434N|SLC4A10_uc010zcr.1_RNA|SLC4A10_uc002uby.3_Missense_Mutation_p.D392N|SLC4A10_uc010zcs.1_Missense_Mutation_p.D403N	NM_022058	NP_071341	Q6U841	S4A10_HUMAN	solute carrier family 4, sodium bicarbonate	422	Cytoplasmic (Potential).				bicarbonate transport|chloride transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity|symporter activity			ovary(2)|lung(2)|pancreas(1)	5						TGAGTTTCTGGATCAGGTTAC	0.358													15	46	---	---	---	---	PASS
SCN2A	6326	broad.mit.edu	37	2	166165901	166165901	+	Silent	SNP	G	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr2:166165901G>C	uc002udc.2	+	6	935	c.645G>C	c.(643-645)GCG>GCC	p.A215A	SCN2A_uc002udd.2_Silent_p.A215A|SCN2A_uc002ude.2_Intron	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	215	Helical; Voltage-sensor; Name=S4 of repeat I; (Potential).|I.				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	ATGTCTCAGCGTTGAGAACAT	0.438													52	52	---	---	---	---	PASS
CIR1	9541	broad.mit.edu	37	2	175213308	175213308	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr2:175213308G>A	uc002uim.2	-	10	1363	c.1270C>T	c.(1270-1272)CAT>TAT	p.H424Y	CIR1_uc002uin.2_Missense_Mutation_p.H298Y|CIR1_uc002uio.2_Missense_Mutation_p.H251Y|CIR1_uc002uip.2_Missense_Mutation_p.H313Y	NM_004882	NP_004873	Q86X95	CIR1_HUMAN	CBF1 interacting corepressor	424	Arg/Ser-rich (RS domain).				mRNA processing|negative regulation of transcription, DNA-dependent|RNA splicing	nuclear speck	protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			large_intestine(1)	1						TCTGTGCCATGGCTTCTGCTG	0.463													165	270	---	---	---	---	PASS
WIPF1	7456	broad.mit.edu	37	2	175436784	175436784	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr2:175436784G>A	uc002uiy.2	-	6	1081	c.749C>T	c.(748-750)CCT>CTT	p.P250L	uc002uiw.2_Intron|uc002uix.1_Intron|WIPF1_uc002uja.2_Missense_Mutation_p.P250L|WIPF1_uc010fqt.1_Missense_Mutation_p.P250L|WIPF1_uc002ujc.1_Missense_Mutation_p.P250L|WIPF1_uc002uiz.2_Missense_Mutation_p.P250L|WIPF1_uc002ujb.1_Missense_Mutation_p.P250L|WIPF1_uc010zep.1_Missense_Mutation_p.P250L	NM_003387	NP_003378	O43516	WIPF1_HUMAN	WAS/WASL interacting protein family, member 1	250					actin polymerization or depolymerization|protein complex assembly	cytoplasmic membrane-bounded vesicle	actin binding|profilin binding			ovary(1)|skin(1)	2						CGGCAGGGGAGGCCGGTTGGA	0.657													9	8	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179588322	179588322	+	Missense_Mutation	SNP	T	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr2:179588322T>A	uc010zfg.1	-	71	17997	c.17773A>T	c.(17773-17775)AAC>TAC	p.N5925Y	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.N2586Y	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6852							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			CTGAACCAGTTGACTTTGAAT	0.418													27	35	---	---	---	---	PASS
DNAH7	56171	broad.mit.edu	37	2	196737067	196737067	+	Silent	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr2:196737067G>T	uc002utj.3	-	40	6641	c.6540C>A	c.(6538-6540)CTC>CTA	p.L2180L		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	2180	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						AGAAATCACGGAGGTTGAACA	0.393													4	137	---	---	---	---	PASS
DNAH7	56171	broad.mit.edu	37	2	196849409	196849409	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr2:196849409C>A	uc002utj.3	-	15	1881	c.1780G>T	c.(1780-1782)GCT>TCT	p.A594S		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	594	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						GCTTTTTCAGCTATCCTCTCA	0.308													26	81	---	---	---	---	PASS
SATB2	23314	broad.mit.edu	37	2	200137310	200137310	+	Missense_Mutation	SNP	T	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr2:200137310T>C	uc002uuy.1	-	11	2643	c.1826A>G	c.(1825-1827)GAC>GGC	p.D609G	SATB2_uc010fsq.1_Missense_Mutation_p.D491G|SATB2_uc002uuz.1_Missense_Mutation_p.D609G|SATB2_uc002uva.1_Missense_Mutation_p.D609G	NM_015265	NP_056080	Q9UPW6	SATB2_HUMAN	SATB homeobox 2	609						cytoplasm|nuclear matrix	sequence-specific DNA binding transcription factor activity			ovary(1)	1						GGCACAACTGTCTTCAGTCGG	0.527													33	109	---	---	---	---	PASS
AOX1	316	broad.mit.edu	37	2	201521602	201521602	+	Missense_Mutation	SNP	T	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr2:201521602T>C	uc002uvx.2	+	27	3214	c.3113T>C	c.(3112-3114)GTG>GCG	p.V1038A	AOX1_uc010zhf.1_Missense_Mutation_p.V594A|AOX1_uc010fsu.2_Missense_Mutation_p.V404A	NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	1038					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	GATGGCTCTGTGCTGGTCACT	0.423													21	59	---	---	---	---	PASS
ACADL	33	broad.mit.edu	37	2	211082716	211082716	+	Missense_Mutation	SNP	T	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr2:211082716T>A	uc002vdz.3	-	3	572	c.344A>T	c.(343-345)TAC>TTC	p.Y115F	ACADL_uc010zjg.1_Missense_Mutation_p.Y115F	NM_001608	NP_001599	P28330	ACADL_HUMAN	long-chain acyl-CoA dehydrogenase precursor	115					carnitine catabolic process|carnitine metabolic process, CoA-linked|fatty acid beta-oxidation using acyl-CoA dehydrogenase|negative regulation of fatty acid biosynthetic process|negative regulation of fatty acid oxidation|regulation of cholesterol metabolic process|temperature homeostasis	mitochondrial matrix	long-chain-acyl-CoA dehydrogenase activity|palmitoyl-CoA oxidase activity				0		Renal(323;0.202)		Epithelial(149;0.00631)|Lung(261;0.0438)|LUSC - Lung squamous cell carcinoma(261;0.0466)|all cancers(144;0.0621)		AGCTGCGGAGTACAGATCCCC	0.438													12	70	---	---	---	---	PASS
ERBB4	2066	broad.mit.edu	37	2	212989624	212989624	+	Nonsense_Mutation	SNP	A	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr2:212989624A>T	uc002veg.1	-	2	185	c.87T>A	c.(85-87)TGT>TGA	p.C29*	ERBB4_uc002veh.1_Nonsense_Mutation_p.C29*|ERBB4_uc010zji.1_Nonsense_Mutation_p.C29*|ERBB4_uc010zjj.1_Nonsense_Mutation_p.C29*|ERBB4_uc010fut.1_Nonsense_Mutation_p.C29*	NM_005235	NP_005226	Q15303	ERBB4_HUMAN	v-erb-a erythroblastic leukemia viral oncogene	29	Extracellular (Potential).				cell proliferation|regulation of transcription, DNA-dependent|transcription, DNA-dependent|transmembrane receptor protein tyrosine kinase signaling pathway	basolateral plasma membrane|cytoplasm|integral to membrane|nucleus	ATP binding|protein binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			lung(21)|skin(5)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	33		Renal(323;0.06)|Lung NSC(271;0.197)		UCEC - Uterine corpus endometrioid carcinoma (47;0.214)|Epithelial(149;5.86e-06)|all cancers(144;2.95e-05)|Lung(261;0.00244)|LUSC - Lung squamous cell carcinoma(224;0.00266)		CCGTTCCTGCACACACTGCAA	0.423										TSP Lung(8;0.080)			19	19	---	---	---	---	PASS
FN1	2335	broad.mit.edu	37	2	216274441	216274441	+	Missense_Mutation	SNP	G	A	A	rs144664306		TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr2:216274441G>A	uc002vfa.2	-	15	2410	c.2144C>T	c.(2143-2145)ACG>ATG	p.T715M	FN1_uc002vfb.2_Missense_Mutation_p.T715M|FN1_uc002vfc.2_Missense_Mutation_p.T715M|FN1_uc002vfd.2_Missense_Mutation_p.T715M|FN1_uc002vfe.2_Missense_Mutation_p.T715M|FN1_uc002vff.2_Missense_Mutation_p.T715M|FN1_uc002vfg.2_Missense_Mutation_p.T715M|FN1_uc002vfh.2_Missense_Mutation_p.T715M|FN1_uc002vfi.2_Missense_Mutation_p.T715M|FN1_uc002vfj.2_Missense_Mutation_p.T715M	NM_212482	NP_997647	P02751	FINC_HUMAN	fibronectin 1 isoform 1 preproprotein	715					acute-phase response|angiogenesis|leukocyte migration|peptide cross-linking|platelet activation|platelet degranulation|regulation of cell shape|substrate adhesion-dependent cell spreading	ER-Golgi intermediate compartment|fibrinogen complex|platelet alpha granule lumen|proteinaceous extracellular matrix	collagen binding|extracellular matrix structural constituent|heparin binding			central_nervous_system(7)|large_intestine(2)|breast(2)|ovary(1)|pancreas(1)	13		Renal(323;0.127)		Epithelial(149;9.59e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)	Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	AAAGGGAGTCGTCTCTCCTGT	0.502													11	28	---	---	---	---	PASS
ASB18	401036	broad.mit.edu	37	2	237149976	237149976	+	Missense_Mutation	SNP	T	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr2:237149976T>C	uc010znh.1	-	2	275	c.275A>G	c.(274-276)AAT>AGT	p.N92S	ASB18_uc010fyp.1_Missense_Mutation_p.N63S	NM_212556	NP_997721	Q6ZVZ8	ASB18_HUMAN	ankyrin repeat and SOCS box-containing 18	92					intracellular signal transduction					ovary(1)	1		all_hematologic(139;0.00615)|Renal(207;0.00963)|Breast(86;0.0126)|Acute lymphoblastic leukemia(138;0.0815)		Epithelial(121;2.04e-26)|OV - Ovarian serous cystadenocarcinoma(60;1.47e-11)|BRCA - Breast invasive adenocarcinoma(100;2.88e-05)|Lung(119;0.000383)|LUSC - Lung squamous cell carcinoma(224;0.00644)|GBM - Glioblastoma multiforme(43;0.244)		CTCATCCTTATTGATCTCAAA	0.498													16	42	---	---	---	---	PASS
GPR35	2859	broad.mit.edu	37	2	241569781	241569781	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr2:241569781G>A	uc002vzs.1	+	1	987	c.412G>A	c.(412-414)GCG>ACG	p.A138T	GPR35_uc010fzh.1_Missense_Mutation_p.A169T|GPR35_uc010fzi.1_Missense_Mutation_p.A169T	NM_005301	NP_005292	Q9HC97	GPR35_HUMAN	G protein-coupled receptor 35	138	Helical; Name=4; (Potential).					integral to plasma membrane	G-protein coupled receptor activity			skin(2)|pancreas(1)	3		all_epithelial(40;7.49e-12)|Breast(86;0.000148)|Renal(207;0.00571)|Ovarian(221;0.104)|all_neural(83;0.107)|all_hematologic(139;0.182)|all_lung(227;0.186)|Melanoma(123;0.238)		Epithelial(32;5.29e-32)|all cancers(36;1.38e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.13e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;5.02e-06)|Lung(119;0.00163)|Colorectal(34;0.00463)|LUSC - Lung squamous cell carcinoma(224;0.008)|COAD - Colon adenocarcinoma(134;0.031)		GGCCGTGTGCGCGGTCCTCTG	0.706													8	10	---	---	---	---	PASS
GADL1	339896	broad.mit.edu	37	3	30842566	30842566	+	Missense_Mutation	SNP	T	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr3:30842566T>A	uc003cep.2	-	12	1112	c.1065A>T	c.(1063-1065)AAA>AAT	p.K355N	GADL1_uc003ceq.1_Missense_Mutation_p.K355N	NM_207359	NP_997242	Q6ZQY3	GADL1_HUMAN	glutamate decarboxylase-like 1	355					carboxylic acid metabolic process		carboxy-lyase activity|pyridoxal phosphate binding				0					Pyridoxal Phosphate(DB00114)	CAGAGTAGCATTTTTTAAGAA	0.368													37	27	---	---	---	---	PASS
ZNF502	91392	broad.mit.edu	37	3	44761767	44761767	+	Missense_Mutation	SNP	A	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr3:44761767A>T	uc011baa.1	+	3	269	c.14A>T	c.(13-15)CAA>CTA	p.Q5L	ZNF502_uc003cns.2_Missense_Mutation_p.Q5L|ZNF502_uc011bab.1_Missense_Mutation_p.Q5L|ZNF502_uc003cnt.2_Missense_Mutation_p.Q5L	NM_001134440	NP_001127912	Q8TBZ5	ZN502_HUMAN	zinc finger protein 502	5					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00855)|KIRC - Kidney renal clear cell carcinoma(197;0.0471)|Kidney(197;0.0589)		TTGAATATGCAAGGAGCTGAA	0.478													41	28	---	---	---	---	PASS
IQCF3	401067	broad.mit.edu	37	3	51864598	51864598	+	Silent	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr3:51864598G>T	uc010hlx.1	+	5	587	c.246G>T	c.(244-246)CTG>CTT	p.L82L	IQCF1_uc003dbq.3_Intron|IQCF3_uc010hlw.1_RNA|IQCF3_uc011bdw.1_RNA	NM_001085479	NP_001078948	P0C7M6	IQCF3_HUMAN	IQ motif containing F3	82										ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000539)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		GGCAGGCCCTGTTGAGGGTCT	0.622													26	21	---	---	---	---	PASS
C3orf64	285203	broad.mit.edu	37	3	69054327	69054327	+	Missense_Mutation	SNP	T	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr3:69054327T>C	uc003dnl.2	-	7	884	c.479A>G	c.(478-480)TAT>TGT	p.Y160C	C3orf64_uc003dnk.2_Missense_Mutation_p.Y160C|C3orf64_uc011bfw.1_RNA|C3orf64_uc003dnm.1_RNA	NM_173654	NP_775925	Q5NDL2	AER61_HUMAN	AER61 glycosyltransferase	160						extracellular region	transferase activity, transferring glycosyl groups			ovary(1)	1		Lung NSC(201;0.126)		BRCA - Breast invasive adenocarcinoma(55;4.61e-05)|Epithelial(33;0.000291)|LUSC - Lung squamous cell carcinoma(21;0.0127)|KIRC - Kidney renal clear cell carcinoma(39;0.216)		TAAATCAAGATAGAGATTGGT	0.353													3	95	---	---	---	---	PASS
PAQR9	344838	broad.mit.edu	37	3	142681325	142681325	+	Missense_Mutation	SNP	A	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr3:142681325A>T	uc003evg.2	-	1	854	c.854T>A	c.(853-855)GTG>GAG	p.V285E	PAQR9_uc003evf.1_RNA	NM_198504	NP_940906	Q6ZVX9	PAQR9_HUMAN	progestin and adipoQ receptor family member IX	285	Extracellular (Potential).					integral to membrane	receptor activity				0						GGCGGCCACCACCAGCCAGAA	0.597													8	147	---	---	---	---	PASS
PAQR9	344838	broad.mit.edu	37	3	142681705	142681705	+	Nonsense_Mutation	SNP	G	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr3:142681705G>C	uc003evg.2	-	1	474	c.474C>G	c.(472-474)TAC>TAG	p.Y158*	PAQR9_uc003evf.1_5'Flank	NM_198504	NP_940906	Q6ZVX9	PAQR9_HUMAN	progestin and adipoQ receptor family member IX	158	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						TGATGGACGCGTAGTCCAGGT	0.612													14	63	---	---	---	---	PASS
PAQR9	344838	broad.mit.edu	37	3	142681846	142681846	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr3:142681846G>T	uc003evg.2	-	1	333	c.333C>A	c.(331-333)GAC>GAA	p.D111E	PAQR9_uc003evf.1_5'Flank	NM_198504	NP_940906	Q6ZVX9	PAQR9_HUMAN	progestin and adipoQ receptor family member IX	111	Extracellular (Potential).					integral to membrane	receptor activity				0						GGAAGGGCACGTCGCCGCCGC	0.622													14	60	---	---	---	---	PASS
CHST2	9435	broad.mit.edu	37	3	142841059	142841059	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr3:142841059G>T	uc003evm.2	+	2	2290	c.1401G>T	c.(1399-1401)AAG>AAT	p.K467N		NM_004267	NP_004258	Q9Y4C5	CHST2_HUMAN	carbohydrate (N-acetylglucosamine-6-O)	467	Lumenal (Potential).				inflammatory response|multicellular organismal development|N-acetylglucosamine metabolic process|sulfur compound metabolic process	integral to membrane|intrinsic to Golgi membrane|trans-Golgi network	N-acetylglucosamine 6-O-sulfotransferase activity			ovary(3)	3						CCTCCTCCAAGCCTTTCGTGG	0.577													22	118	---	---	---	---	PASS
DHX36	170506	broad.mit.edu	37	3	154010470	154010470	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr3:154010470C>T	uc003ezy.3	-	15	1765	c.1684G>A	c.(1684-1686)GAT>AAT	p.D562N	DHX36_uc010hvq.2_Missense_Mutation_p.D548N|DHX36_uc003ezz.3_Missense_Mutation_p.D562N	NM_020865	NP_065916	Q9H2U1	DHX36_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 36	562	Helicase C-terminal.					cytoplasm|nucleus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1			LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.173)			TAAACGACATCATCTATGGTA	0.274													7	320	---	---	---	---	PASS
GOLIM4	27333	broad.mit.edu	37	3	167750570	167750570	+	Missense_Mutation	SNP	T	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr3:167750570T>C	uc003ffe.2	-	9	1258	c.914A>G	c.(913-915)TAT>TGT	p.Y305C	GOLIM4_uc011bpe.1_Missense_Mutation_p.Y305C|GOLIM4_uc011bpf.1_Missense_Mutation_p.Y277C|GOLIM4_uc011bpg.1_Missense_Mutation_p.Y277C	NM_014498	NP_055313	O00461	GOLI4_HUMAN	golgi integral membrane protein 4	305	Lumenal (Potential).				transport	cis-Golgi network|endocytic vesicle|endosome membrane|Golgi cisterna membrane|Golgi lumen|integral to membrane|nucleus				breast(4)|skin(1)	5						GGTGGGAGCATAGAGTTTTGT	0.507													78	247	---	---	---	---	PASS
TNIK	23043	broad.mit.edu	37	3	170811627	170811627	+	Splice_Site	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr3:170811627C>T	uc003fhh.2	-	23	3066	c.2721_splice	c.e23+1	p.E907_splice	TNIK_uc003fhi.2_Splice_Site_p.E852_splice|TNIK_uc003fhj.2_Splice_Site_p.E878_splice|TNIK_uc003fhk.2_Splice_Site_p.E899_splice|TNIK_uc003fhl.2_Splice_Site_p.E823_splice|TNIK_uc003fhm.2_Splice_Site_p.E844_splice|TNIK_uc003fhn.2_Splice_Site_p.E870_splice|TNIK_uc003fho.2_Splice_Site_p.E815_splice|TNIK_uc003fhg.2_Splice_Site_p.E85_splice	NM_015028	NP_055843	Q9UKE5	TNIK_HUMAN	TRAF2 and NCK interacting kinase isoform 1						actin cytoskeleton reorganization|activation of JNKK activity|protein autophosphorylation|regulation of dendrite morphogenesis|Wnt receptor signaling pathway	cytoskeleton|nucleus|recycling endosome	ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(4)|large_intestine(1)	5	all_cancers(22;2.55e-19)|all_lung(20;2.22e-14)|Ovarian(172;0.00197)|Breast(254;0.122)		LUSC - Lung squamous cell carcinoma(14;3.57e-14)|Lung(28;9.39e-14)			TACCAACTTACCTCTCTAATC	0.423													11	142	---	---	---	---	PASS
DCUN1D1	54165	broad.mit.edu	37	3	182683507	182683507	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr3:182683507C>T	uc003fld.1	-	2	87	c.38G>A	c.(37-39)CGT>CAT	p.R13H	DCUN1D1_uc011bqn.1_5'UTR	NM_020640	NP_065691	Q96GG9	DCNL1_HUMAN	RP42 homolog	13	UBA-like.					ubiquitin ligase complex	protein binding			ovary(1)	1	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;2.54e-44)|Epithelial(37;4.71e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;7.41e-21)			CATAAACTGACGAACTTTATC	0.303													44	400	---	---	---	---	PASS
MUC4	4585	broad.mit.edu	37	3	195517097	195517097	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr3:195517097G>A	uc011bto.1	-	2	1814	c.1354C>T	c.(1354-1356)CAC>TAC	p.H452Y	MUC4_uc003fvo.2_Intron|MUC4_uc003fvp.2_Intron|MUC4_uc010hzu.1_Missense_Mutation_p.H334Y	NM_018406	NP_060876	Q99102	MUC4_HUMAN	mucin 4 isoform a	457					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity				0	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TGCTGGGTGTGGAAAGCTGTG	0.473													485	187	---	---	---	---	PASS
SENP5	205564	broad.mit.edu	37	3	196654678	196654678	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr3:196654678G>T	uc003fwz.3	+	8	2283	c.2034G>T	c.(2032-2034)AAG>AAT	p.K678N	SENP5_uc011bty.1_Missense_Mutation_p.K632N	NM_152699	NP_689912	Q96HI0	SENP5_HUMAN	SUMO1/sentrin specific peptidase 5	678	Protease.				cell cycle|cell division|proteolysis	nucleolus	cysteine-type peptidase activity			breast(2)|lung(1)	3	all_cancers(143;1.8e-08)|Ovarian(172;0.0634)|Breast(254;0.135)		Epithelial(36;3.14e-24)|all cancers(36;2.1e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.03e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.004)		ATATAAGAAAGTATTTGCTGA	0.403													99	44	---	---	---	---	PASS
LMLN	89782	broad.mit.edu	37	3	197762799	197762799	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr3:197762799G>A	uc011buo.1	+	15	1774	c.1752G>A	c.(1750-1752)ATG>ATA	p.M584I	LMLN_uc003fyt.2_Missense_Mutation_p.M569I|LMLN_uc010iar.2_Missense_Mutation_p.M621I|LMLN_uc010ias.2_Missense_Mutation_p.M532I|LMLN_uc003fyu.2_Missense_Mutation_p.M381I	NM_033029	NP_149018	Q96KR4	LMLN_HUMAN	leishmanolysin-like isoform 2	584					cell adhesion|cell division|mitosis|proteolysis	cytoplasm|membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1	all_cancers(143;1.15e-09)|Ovarian(172;0.0418)|Breast(254;0.0976)	Lung NSC(153;0.132)	Epithelial(36;9.84e-24)|all cancers(36;3.18e-22)|OV - Ovarian serous cystadenocarcinoma(49;5.35e-19)|LUSC - Lung squamous cell carcinoma(58;6.94e-07)|Lung(62;9.92e-07)	GBM - Glioblastoma multiforme(93;0.111)		GTATCCAGATGAATGGCTGGA	0.502													247	92	---	---	---	---	PASS
GBA3	57733	broad.mit.edu	37	4	22820400	22820400	+	Missense_Mutation	SNP	A	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr4:22820400A>T	uc003gqp.3	+	5	1355	c.1264A>T	c.(1264-1266)AAC>TAC	p.N422Y	GBA3_uc010iep.2_Missense_Mutation_p.N115Y|GBA3_uc011bxo.1_Missense_Mutation_p.N423Y	NM_020973	NP_066024	Q9H227	GBA3_HUMAN	cytosolic beta-glucosidase isoform a	422					glycoside catabolic process|glycosylceramide catabolic process	cytosol	beta-galactosidase activity|beta-glucosidase activity|cation binding|glycosylceramidase activity				0						TCTTCTGGATAACTTTGAGTG	0.423													5	14	---	---	---	---	PASS
SLAIN2	57606	broad.mit.edu	37	4	48422177	48422177	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr4:48422177C>T	uc003gya.3	+	7	1540	c.1396C>T	c.(1396-1398)CCA>TCA	p.P466S		NM_020846	NP_065897	Q9P270	SLAI2_HUMAN	SLAIN motif family, member 2	466						centrosome					0						CCCTGCAGCACCATCTCCTTT	0.448													48	25	---	---	---	---	PASS
HERC3	8916	broad.mit.edu	37	4	89527029	89527029	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr4:89527029C>A	uc003hrw.1	+	3	221	c.55C>A	c.(55-57)CAG>AAG	p.Q19K	HERC3_uc003hrv.2_Missense_Mutation_p.Q19K|HERC3_uc011cdn.1_Intron	NM_014606	NP_055421	Q15034	HERC3_HUMAN	hect domain and RLD 3	19	RCC1 1.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasmic membrane-bounded vesicle	ubiquitin-protein ligase activity			lung(2)|prostate(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(123;0.000319)		CACCAACCTGCAGGGAATTGT	0.493													49	24	---	---	---	---	PASS
GRID2	2895	broad.mit.edu	37	4	94006266	94006266	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr4:94006266C>T	uc011cdt.1	+	3	623	c.365C>T	c.(364-366)TCA>TTA	p.S122L	GRID2_uc010ikx.2_Missense_Mutation_p.S122L|GRID2_uc011cdu.1_Intron|GRID2_uc011cdv.1_RNA	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	122	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	ATTCAGCGCTCAACAGCTGGG	0.567													59	37	---	---	---	---	PASS
EMCN	51705	broad.mit.edu	37	4	101342458	101342458	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr4:101342458C>A	uc003hvr.2	-	8	824	c.645G>T	c.(643-645)ATG>ATT	p.M215I	EMCN_uc011cel.1_Missense_Mutation_p.M202I|EMCN_uc011cem.1_Intron	NM_016242	NP_057326	Q9ULC0	MUCEN_HUMAN	endomucin isoform 1	215	Cytoplasmic (Potential).					extracellular region|integral to membrane|plasma membrane					0				OV - Ovarian serous cystadenocarcinoma(123;2.49e-08)		CCTTCCAGCACATTCGGTACA	0.358													58	33	---	---	---	---	PASS
C4orf21	55345	broad.mit.edu	37	4	113538950	113538950	+	Missense_Mutation	SNP	A	G	G			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr4:113538950A>G	uc003iau.2	-	6	2459	c.2248T>C	c.(2248-2250)TGT>CGT	p.C750R	C4orf21_uc003iaw.2_Missense_Mutation_p.C750R	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	Error:Variant_position_missing_in_Q6ZU11_after_alignment						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		AGTGCAATACATTCATAGTGA	0.343													97	39	---	---	---	---	PASS
C4orf31	79625	broad.mit.edu	37	4	121957867	121957867	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr4:121957867C>T	uc003idq.1	-	4	1786	c.1259G>A	c.(1258-1260)CGA>CAA	p.R420Q		NM_024574	NP_078850	Q8TB73	CD031_HUMAN	hypothetical protein LOC79625 precursor	420											0						TCCTTTCAGTCGAACGAGGTA	0.418													123	81	---	---	---	---	PASS
RXFP1	59350	broad.mit.edu	37	4	159514595	159514595	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr4:159514595C>A	uc003ipz.2	+	3	312	c.230C>A	c.(229-231)GCC>GAC	p.A77D	RXFP1_uc010iqj.1_5'UTR|RXFP1_uc011cja.1_5'UTR|RXFP1_uc010iqo.2_Missense_Mutation_p.A77D|RXFP1_uc011cjb.1_5'UTR|RXFP1_uc010iqk.2_5'UTR|RXFP1_uc011cjc.1_5'UTR|RXFP1_uc011cjd.1_5'UTR|RXFP1_uc010iql.2_5'UTR|RXFP1_uc011cje.1_Missense_Mutation_p.A77D|RXFP1_uc010iqm.2_Intron|RXFP1_uc011cjf.1_Intron|RXFP1_uc010iqn.2_5'UTR	NM_021634	NP_067647	Q9HBX9	RXFP1_HUMAN	relaxin/insulin-like family peptide receptor 1	77	Extracellular (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|metal ion binding				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.0219)		AAATATTTTGCCAGTTACTAC	0.333													24	25	---	---	---	---	PASS
C4orf39	152756	broad.mit.edu	37	4	165878495	165878495	+	Silent	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr4:165878495G>T	uc003iqx.1	+	1	396	c.321G>T	c.(319-321)ACG>ACT	p.T107T	TRIM61_uc003iqw.2_Intron	NM_153027	NP_694572	Q96MZ4	CD039_HUMAN	hypothetical protein LOC152756	107											0	all_hematologic(180;0.221)	Prostate(90;0.109)		GBM - Glioblastoma multiforme(119;0.146)		CGGCTGTCACGCCACCGAAAT	0.547													23	24	---	---	---	---	PASS
DDX60L	91351	broad.mit.edu	37	4	169392938	169392938	+	Missense_Mutation	SNP	A	G	G			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr4:169392938A>G	uc003irq.3	-	4	445	c.224T>C	c.(223-225)CTT>CCT	p.L75P	DDX60L_uc003irr.1_Missense_Mutation_p.L75P|DDX60L_uc003irt.1_Missense_Mutation_p.L75P	NM_001012967	NP_001012985	Q5H9U9	DDX6L_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like	75							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.175)		GTTACTCAGAAGATCCACAAG	0.373													46	50	---	---	---	---	PASS
SH3RF1	57630	broad.mit.edu	37	4	170057544	170057544	+	Silent	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr4:170057544G>A	uc003isa.1	-	5	1328	c.993C>T	c.(991-993)CTC>CTT	p.L331L	SH3RF1_uc010irc.1_Missense_Mutation_p.H54Y	NM_020870	NP_065921	Q7Z6J0	SH3R1_HUMAN	SH3 domain containing ring finger 1	331						Golgi apparatus|lamellipodium|perinuclear region of cytoplasm	ligase activity|zinc ion binding			breast(2)|lung(1)	3		Prostate(90;0.00267)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)		TGGAGCTGATGAGGACAGGGG	0.562													97	145	---	---	---	---	PASS
PLEKHG4B	153478	broad.mit.edu	37	5	163559	163559	+	Silent	SNP	G	T	T	rs114260538	byFrequency	TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr5:163559G>T	uc003jak.2	+	11	2354	c.2304G>T	c.(2302-2304)CCG>CCT	p.P768P		NM_052909	NP_443141	Q96PX9	PKH4B_HUMAN	pleckstrin homology domain containing, family G	768					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			skin(2)	2			all cancers(22;0.0253)|Lung(60;0.113)	Kidney(1;0.119)		AGAAGCTCCCGCTGTGGCAGC	0.652													19	15	---	---	---	---	PASS
CDH18	1016	broad.mit.edu	37	5	19473725	19473725	+	Missense_Mutation	SNP	T	G	G			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr5:19473725T>G	uc003jgc.2	-	12	2360	c.1983A>C	c.(1981-1983)GAA>GAC	p.E661D	CDH18_uc003jgd.2_Missense_Mutation_p.E661D|CDH18_uc011cnm.1_3'UTR	NM_004934	NP_004925	Q13634	CAD18_HUMAN	cadherin 18, type 2 preproprotein	661	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|large_intestine(1)|skin(1)	7	Lung NSC(1;0.00734)|all_lung(1;0.0197)					CTCCGCCTCCTTCATCATCAT	0.498													76	109	---	---	---	---	PASS
CDH10	1008	broad.mit.edu	37	5	24537623	24537623	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr5:24537623G>T	uc003jgr.1	-	3	724	c.392C>A	c.(391-393)GCT>GAT	p.A131D	CDH10_uc011cnu.1_RNA	NM_006727	NP_006718	Q9Y6N8	CAD10_HUMAN	cadherin 10, type 2 preproprotein	131	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(6)|pancreas(4)|breast(2)	12				STAD - Stomach adenocarcinoma(35;0.0556)		TCTGTTAATAGCTTGTGCGCG	0.403										HNSCC(23;0.051)			28	116	---	---	---	---	PASS
CDH9	1007	broad.mit.edu	37	5	26903886	26903886	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr5:26903886G>A	uc003jgs.1	-	6	1028	c.859C>T	c.(859-861)CTT>TTT	p.L287F	CDH9_uc010iug.2_Missense_Mutation_p.L287F	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	287	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						ATCCTTCCAAGATGAGTTCCA	0.378													20	108	---	---	---	---	PASS
TTC33	23548	broad.mit.edu	37	5	40716530	40716530	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr5:40716530G>A	uc003jma.2	-	5	654	c.506C>T	c.(505-507)TCT>TTT	p.S169F	TTC33_uc011cpm.1_Missense_Mutation_p.S61F|TTC33_uc010ivg.2_3'UTR	NM_012382	NP_036514	Q6PID6	TTC33_HUMAN	tetratricopeptide repeat domain 33	169							binding			ovary(1)	1						TCTTGCCCAAGAGAGGTCTTC	0.408													101	115	---	---	---	---	PASS
RAB3C	115827	broad.mit.edu	37	5	58021831	58021831	+	Missense_Mutation	SNP	C	G	G			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr5:58021831C>G	uc003jrp.2	+	3	352	c.255C>G	c.(253-255)GAC>GAG	p.D85E		NM_138453	NP_612462	Q96E17	RAB3C_HUMAN	RAB3C, member RAS oncogene family	85	GTP (By similarity).				protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding			ovary(1)|central_nervous_system(1)	2		all_cancers(5;9.93e-10)|all_epithelial(5;1.49e-10)|all_lung(5;8.97e-05)|Lung NSC(5;0.000139)|Prostate(74;0.0664)		OV - Ovarian serous cystadenocarcinoma(10;1.8e-34)		TTCTTTAGGACACAGCAGGCC	0.338													43	79	---	---	---	---	PASS
MAP1B	4131	broad.mit.edu	37	5	71491608	71491608	+	Missense_Mutation	SNP	T	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr5:71491608T>A	uc003kbw.3	+	5	2667	c.2426T>A	c.(2425-2427)ATG>AAG	p.M809K	MAP1B_uc010iyw.1_Missense_Mutation_p.M826K|MAP1B_uc010iyx.1_Missense_Mutation_p.M683K|MAP1B_uc010iyy.1_Missense_Mutation_p.M683K	NM_005909	NP_005900	P46821	MAP1B_HUMAN	microtubule-associated protein 1B	809						microtubule|microtubule associated complex	structural molecule activity			large_intestine(2)|ovary(1)|central_nervous_system(1)|pancreas(1)	5		Lung NSC(167;0.00202)|Ovarian(174;0.0175)|Prostate(461;0.142)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;7.99e-54)		GCAGCTGTCATGGCGGCAGCT	0.537													7	1	---	---	---	---	PASS
IQGAP2	10788	broad.mit.edu	37	5	75950040	75950040	+	Nonsense_Mutation	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr5:75950040C>T	uc003kek.2	+	19	2416	c.2194C>T	c.(2194-2196)CGA>TGA	p.R732*	IQGAP2_uc010izv.2_Nonsense_Mutation_p.R285*|IQGAP2_uc011csv.1_Nonsense_Mutation_p.R228*|IQGAP2_uc003kel.2_Nonsense_Mutation_p.R228*	NM_006633	NP_006624	Q13576	IQGA2_HUMAN	IQ motif containing GTPase activating protein 2	732	IQ 2.				small GTPase mediated signal transduction	actin cytoskeleton	actin binding|calmodulin binding|GTPase inhibitor activity|Ras GTPase activator activity			ovary(6)|central_nervous_system(1)	7		all_lung(232;0.000514)|Lung NSC(167;0.00135)|Prostate(461;0.00838)|Ovarian(174;0.0149)		all cancers(79;1.38e-36)		GTCCTGGTTCCGAATGGCAAC	0.348													15	74	---	---	---	---	PASS
PCDHA13	56136	broad.mit.edu	37	5	140262150	140262150	+	Silent	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr5:140262150C>T	uc003lif.2	+	1	297	c.297C>T	c.(295-297)AGC>AGT	p.S99S	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc003lhq.2_Intron|PCDHA8_uc003lhs.2_Intron|PCDHA9_uc003lhu.2_Intron|PCDHA10_uc003lhw.2_Intron|PCDHA10_uc003lhx.2_Intron|PCDHA11_uc003lia.2_Intron|PCDHA12_uc003lic.2_Intron|PCDHA13_uc003lie.1_Silent_p.S99S|PCDHA13_uc003lid.2_Silent_p.S99S	NM_018904	NP_061727	Q9Y5I0	PCDAD_HUMAN	protocadherin alpha 13 isoform 1 precursor	99	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|skin(2)|central_nervous_system(1)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GTGGGCGGAGCGCGGAGTGCA	0.557													46	194	---	---	---	---	PASS
FAT2	2196	broad.mit.edu	37	5	150928931	150928931	+	Missense_Mutation	SNP	T	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr5:150928931T>C	uc003lue.3	-	8	4727	c.4714A>G	c.(4714-4716)ACA>GCA	p.T1572A	GM2A_uc011dcs.1_Intron	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	1572	Extracellular (Potential).|Cadherin 14.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			AGCAGCTCTGTGCCGGGGGCT	0.592													4	28	---	---	---	---	PASS
DOCK2	1794	broad.mit.edu	37	5	169145667	169145667	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr5:169145667G>T	uc003maf.2	+	22	2219	c.2139G>T	c.(2137-2139)TTG>TTT	p.L713F	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.L205F	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	713					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			TCAGGAAATTGATGACAGTGC	0.373													20	28	---	---	---	---	PASS
NRN1	51299	broad.mit.edu	37	6	5999430	5999430	+	Missense_Mutation	SNP	C	G	G			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr6:5999430C>G	uc003mwu.2	-	3	859	c.208G>C	c.(208-210)GAG>CAG	p.E70Q	NRN1_uc003mwt.2_Missense_Mutation_p.E96Q	NM_016588	NP_057672	Q9NPD7	NRN1_HUMAN	neuritin precursor	70						anchored to membrane|plasma membrane					0	Ovarian(93;0.0816)	all_hematologic(90;0.151)		OV - Ovarian serous cystadenocarcinoma(45;0.00415)		TGGAAATCCTCCCAGTATCTG	0.557													18	39	---	---	---	---	PASS
NUP153	9972	broad.mit.edu	37	6	17649457	17649457	+	Silent	SNP	A	G	G			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr6:17649457A>G	uc003ncd.1	-	12	1670	c.1470T>C	c.(1468-1470)AGT>AGC	p.S490S	NUP153_uc011dje.1_Silent_p.S521S|NUP153_uc010jpl.1_Silent_p.S490S	NM_005124	NP_005115	P49790	NU153_HUMAN	nucleoporin 153kDa	490					carbohydrate metabolic process|glucose transport|interspecies interaction between organisms|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	cytoplasm|nuclear membrane|nuclear pore|nucleolus|nucleoplasm	DNA binding|protein binding|transporter activity|zinc ion binding			lung(4)|ovary(2)|breast(2)|skin(1)	9	Breast(50;0.0259)|Ovarian(93;0.0584)	all_hematologic(90;0.125)	all cancers(50;0.0981)|Epithelial(50;0.112)			TCTCAGGGGAACTAAAATTAA	0.368													31	124	---	---	---	---	PASS
SLC17A4	10050	broad.mit.edu	37	6	25773531	25773531	+	Silent	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr6:25773531C>T	uc003nfe.2	+	7	854	c.735C>T	c.(733-735)CTC>CTT	p.L245L	SLC17A4_uc011djx.1_Intron|SLC17A4_uc003nff.1_Intron|SLC17A4_uc003nfg.2_Silent_p.L182L|SLC17A4_uc010jqa.2_5'Flank	NM_005495	NP_005486	Q9Y2C5	S17A4_HUMAN	solute carrier family 17 (sodium phosphate),	245	Helical; (Potential).				phosphate metabolic process	integral to plasma membrane|membrane fraction	sodium:phosphate symporter activity			skin(1)	1						GTTGTCCTCTCTGGTTTCCTC	0.433													26	94	---	---	---	---	PASS
SKIV2L	6499	broad.mit.edu	37	6	31929803	31929803	+	Missense_Mutation	SNP	A	G	G			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr6:31929803A>G	uc003nyn.1	+	10	1425	c.1036A>G	c.(1036-1038)ATT>GTT	p.I346V	RDBP_uc003nyk.2_5'Flank|RDBP_uc011dot.1_5'Flank|RDBP_uc003nym.1_5'Flank|SKIV2L_uc011dou.1_Missense_Mutation_p.I188V|SKIV2L_uc011dov.1_Missense_Mutation_p.I153V	NM_006929	NP_008860	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like homolog	346	Helicase ATP-binding.					nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						TGAATATGCCATTGCCCTGGC	0.502													31	42	---	---	---	---	PASS
DNAH8	1769	broad.mit.edu	37	6	38790651	38790651	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr6:38790651G>T	uc003ooe.1	+	25	3510	c.2910G>T	c.(2908-2910)AAG>AAT	p.K970N		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						GGAAGCTGAAGAATTTTTACC	0.388													12	35	---	---	---	---	PASS
UBR2	23304	broad.mit.edu	37	6	42625796	42625796	+	Missense_Mutation	SNP	A	G	G	rs138557643		TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr6:42625796A>G	uc011dur.1	+	27	2907	c.2907A>G	c.(2905-2907)ATA>ATG	p.I969M	UBR2_uc011dus.1_Missense_Mutation_p.I614M|UBR2_uc003osh.2_RNA	NM_015255	NP_056070	Q8IWV8	UBR2_HUMAN	ubiquitin protein ligase E3 component n-recognin	969					cellular response to leucine|chromatin silencing|histone H2A ubiquitination|negative regulation of TOR signaling cascade	nucleus|plasma membrane	leucine binding|zinc ion binding			ovary(3)|pancreas(1)	4	Colorectal(47;0.196)		Colorectal(64;0.00062)|COAD - Colon adenocarcinoma(64;0.00152)|all cancers(41;0.004)|KIRC - Kidney renal clear cell carcinoma(15;0.02)|Kidney(15;0.0388)|OV - Ovarian serous cystadenocarcinoma(102;0.196)			CTCCTAGCATACTAGCTATGC	0.393													197	158	---	---	---	---	PASS
XPO5	57510	broad.mit.edu	37	6	43498432	43498432	+	Missense_Mutation	SNP	T	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr6:43498432T>A	uc003ovp.2	-	23	2882	c.2671A>T	c.(2671-2673)ATG>TTG	p.M891L		NM_020750	NP_065801	Q9HAV4	XPO5_HUMAN	exportin 5	891					gene silencing by RNA	cytosol|nucleoplasm	protein binding|tRNA binding			skin(2)|breast(1)|kidney(1)	4	all_cancers(18;2.08e-05)|Lung NSC(15;0.000907)|all_lung(25;0.00243)		all cancers(41;0.000321)|Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|OV - Ovarian serous cystadenocarcinoma(102;0.0524)			ATATGAAGCATGGGTCTGAGT	0.448													17	126	---	---	---	---	PASS
SLC29A1	2030	broad.mit.edu	37	6	44199199	44199199	+	Splice_Site	SNP	G	C	C	rs75037270		TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr6:44199199G>C	uc003owu.1	+	9	1193	c.864_splice	c.e9+1	p.N288_splice	SLC29A1_uc003owv.1_Splice_Site_p.N288_splice|SLC29A1_uc003oww.1_Splice_Site_p.N367_splice|SLC29A1_uc003owx.1_Splice_Site_p.N288_splice|SLC29A1_uc003owy.1_Splice_Site_p.N288_splice|SLC29A1_uc003owz.1_Splice_Site_p.N288_splice	NM_004955	NP_004946	Q99808	S29A1_HUMAN	equilibrative nucleoside transporter 1						nucleobase, nucleoside and nucleotide metabolic process	apical plasma membrane|basolateral plasma membrane|integral to plasma membrane|membrane fraction	nucleoside transmembrane transporter activity|protein binding			large_intestine(2)|skin(1)	3	all_cancers(18;3.19e-06)|Lung NSC(15;0.00108)|all_lung(25;0.00278)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)		Troglitazone(DB00197)	CCTGAAAAATGTACGTAGGGG	0.512													9	34	---	---	---	---	PASS
PKHD1	5314	broad.mit.edu	37	6	51613404	51613404	+	Missense_Mutation	SNP	C	G	G			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr6:51613404C>G	uc003pah.1	-	58	9286	c.9010G>C	c.(9010-9012)GTT>CTT	p.V3004L	PKHD1_uc010jzn.1_Missense_Mutation_p.V987L|PKHD1_uc003pai.2_Missense_Mutation_p.V3004L	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1	3004	Extracellular (Potential).				cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CTGAATTCAACAGATGAGTAC	0.458													94	148	---	---	---	---	PASS
BAI3	577	broad.mit.edu	37	6	70049245	70049245	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr6:70049245G>T	uc003pev.3	+	26	3756	c.3308G>T	c.(3307-3309)TGT>TTT	p.C1103F	BAI3_uc010kak.2_Missense_Mutation_p.C1103F|BAI3_uc011dxx.1_Missense_Mutation_p.C309F|BAI3_uc003pex.1_Missense_Mutation_p.C233F	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	1103	Helical; Name=6; (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				TGGAGCTCCTGTGTGGTGTTG	0.468													166	187	---	---	---	---	PASS
TTK	7272	broad.mit.edu	37	6	80750394	80750394	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr6:80750394C>T	uc003pjc.2	+	21	2538	c.2464C>T	c.(2464-2466)CCT>TCT	p.P822S	TTK_uc003pjb.3_Missense_Mutation_p.P821S	NM_003318	NP_003309	P33981	TTK_HUMAN	TTK protein kinase	822					mitotic cell cycle spindle assembly checkpoint|mitotic spindle organization|positive regulation of cell proliferation|positive regulation of pathway-restricted SMAD protein phosphorylation	spindle	ATP binding|identical protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(4)|stomach(2)|lung(2)|large_intestine(2)|pancreas(1)	11		all_cancers(76;0.00177)|Acute lymphoblastic leukemia(125;1.24e-05)|all_hematologic(105;0.00223)|all_epithelial(107;0.2)		BRCA - Breast invasive adenocarcinoma(397;0.0321)		TCTGAATTCTCCTAACTCCAT	0.318													4	114	---	---	---	---	PASS
SYNCRIP	10492	broad.mit.edu	37	6	86324670	86324670	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr6:86324670C>T	uc003pla.2	-	11	2217	c.1676G>A	c.(1675-1677)GGA>GAA	p.G559E	SYNCRIP_uc003pku.2_Intron|SYNCRIP_uc003pkw.2_Intron|SYNCRIP_uc003pky.2_Intron|SYNCRIP_uc003pkv.2_Intron|SYNCRIP_uc003pkx.2_Intron|SYNCRIP_uc003pkz.2_Missense_Mutation_p.G524E	NM_006372	NP_006363	O60506	HNRPQ_HUMAN	synaptotagmin binding, cytoplasmic RNA	559	1-8.|Interaction with APOBEC1.|8 X 3 AA repeats of R-G-G.				CRD-mediated mRNA stabilization|interspecies interaction between organisms	catalytic step 2 spliceosome|CRD-mediated mRNA stability complex|endoplasmic reticulum|histone pre-mRNA 3'end processing complex|microsome|nucleoplasm	nucleotide binding|protein binding			ovary(2)	2		all_cancers(76;0.000137)|Acute lymphoblastic leukemia(125;3.66e-08)|Prostate(29;8.2e-07)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0297)		BRCA - Breast invasive adenocarcinoma(108;0.0389)		TCCTACATTTCCACCGCGGCC	0.597													79	208	---	---	---	---	PASS
C6orf162	57150	broad.mit.edu	37	6	88046835	88046835	+	Missense_Mutation	SNP	G	A	A	rs140990223		TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr6:88046835G>A	uc003plp.1	+	3	175	c.86G>A	c.(85-87)CGC>CAC	p.R29H	C6orf164_uc003plr.2_RNA|C6orf162_uc003plq.1_Missense_Mutation_p.R29H	NM_001042493	NP_001035958	Q96KF7	CF162_HUMAN	hypothetical protein LOC57150	29						integral to membrane					0		all_cancers(76;3.81e-09)|Prostate(29;1.34e-10)|Acute lymphoblastic leukemia(125;2.15e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;5.3e-05)		BRCA - Breast invasive adenocarcinoma(108;0.0164)		AGAGGGGTGCGCACAACAACC	0.438													17	137	---	---	---	---	PASS
MDN1	23195	broad.mit.edu	37	6	90497611	90497611	+	Silent	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr6:90497611C>T	uc003pnn.1	-	8	1412	c.1296G>A	c.(1294-1296)CTG>CTA	p.L432L	MDN1_uc003pno.1_5'Flank|MDN1_uc003pnp.1_Silent_p.L432L	NM_014611	NP_055426	Q9NU22	MDN1_HUMAN	MDN1, midasin homolog	432					protein complex assembly|regulation of protein complex assembly	nucleus	ATP binding|ATPase activity|unfolded protein binding			ovary(8)|skin(2)	10		all_cancers(76;1.47e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.00246)		BRCA - Breast invasive adenocarcinoma(108;0.0193)		GTGCCACTTTCAGACAGTCAC	0.453													35	37	---	---	---	---	PASS
CASP8AP2	9994	broad.mit.edu	37	6	90575901	90575901	+	Silent	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr6:90575901G>A	uc003pnr.2	+	8	3088	c.2892G>A	c.(2890-2892)CGG>CGA	p.R964R	CASP8AP2_uc003pns.2_Intron|CASP8AP2_uc003pnt.2_Silent_p.R964R|CASP8AP2_uc011dzz.1_Silent_p.R964R	NM_001137667	NP_001131139	Q9UKL3	C8AP2_HUMAN	caspase 8 associated protein 2	964					cell cycle|cellular response to mechanical stimulus|induction of apoptosis via death domain receptors|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	cytoplasm|nucleus	caspase activator activity|death receptor binding|transcription corepressor activity			ovary(2)	2		all_cancers(76;3.64e-09)|Prostate(29;1.16e-10)|Acute lymphoblastic leukemia(125;1.45e-10)|all_hematologic(105;7.74e-07)|all_epithelial(107;4.69e-05)|Lung NSC(302;0.238)		BRCA - Breast invasive adenocarcinoma(108;0.0953)		CTGATGTGCGGAAGTCAAAGA	0.363													14	10	---	---	---	---	PASS
MCHR2	84539	broad.mit.edu	37	6	100368871	100368871	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr6:100368871C>A	uc003pqh.1	-	6	1283	c.968G>T	c.(967-969)AGA>ATA	p.R323I	MCHR2_uc003pqi.1_Missense_Mutation_p.R323I	NM_001040179	NP_001035269	Q969V1	MCHR2_HUMAN	melanin-concentrating hormone receptor 2	323	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|skin(1)	8		all_cancers(76;4.87e-05)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.0309)|Colorectal(196;0.069)		BRCA - Breast invasive adenocarcinoma(108;0.0429)		CTCAGTCGCTCTTCTTTGGAT	0.423													33	106	---	---	---	---	PASS
AKD1	221264	broad.mit.edu	37	6	109980541	109980541	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr6:109980541C>T	uc003ptn.2	-	7	597	c.520G>A	c.(520-522)GAC>AAC	p.D174N	AKD1_uc003ptr.3_Missense_Mutation_p.D174N|AKD1_uc003pts.1_RNA	NM_001145128	NP_001138600	Q5TCS8	AKD1_HUMAN	adenylate kinase domain containing 1 isoform 1	174					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|nucleoside-triphosphatase activity			ovary(1)	1						TCCCACTGGTCTCTACTGTAT	0.259													18	63	---	---	---	---	PASS
CDK19	23097	broad.mit.edu	37	6	110944071	110944071	+	Silent	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr6:110944071C>A	uc003puh.1	-	10	1051	c.978G>T	c.(976-978)TCG>TCT	p.S326S	CDK19_uc003pui.1_Silent_p.S266S|CDK19_uc011eax.1_Silent_p.S202S	NM_015076	NP_055891	Q9BWU1	CDK19_HUMAN	cell division cycle 2-like 6 (CDK8-like)	326	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4						GAGCTTGCTCCGAGGTAATTC	0.458													25	82	---	---	---	---	PASS
MIR588	693173	broad.mit.edu	37	6	126805844	126805844	+	RNA	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr6:126805844C>T	hsa-mir-588|MI0003597	+			c.68C>T			uc003qaq.1_Intron																	0						ccaccatggccaaaattgggc	0.000													6	12	---	---	---	---	PASS
SYNE1	23345	broad.mit.edu	37	6	152540290	152540290	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr6:152540290C>A	uc010kiw.2	-	120	22494	c.21892G>T	c.(21892-21894)GAT>TAT	p.D7298Y	SYNE1_uc010kiv.2_Missense_Mutation_p.D1822Y|SYNE1_uc003qos.3_Missense_Mutation_p.D1822Y|SYNE1_uc003qot.3_Missense_Mutation_p.D7227Y|SYNE1_uc003qou.3_Missense_Mutation_p.D7298Y|SYNE1_uc003qor.3_Missense_Mutation_p.D198Y	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7298	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		AAGAGGGAATCTTTAACTGTG	0.448										HNSCC(10;0.0054)			14	78	---	---	---	---	PASS
SYNE1	23345	broad.mit.edu	37	6	152651824	152651824	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr6:152651824C>T	uc010kiw.2	-	78	14598	c.13996G>A	c.(13996-13998)GTC>ATC	p.V4666I	SYNE1_uc003qot.3_Missense_Mutation_p.V4595I|SYNE1_uc003qou.3_Missense_Mutation_p.V4666I|SYNE1_uc010kiz.2_Missense_Mutation_p.V421I	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4666	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		GCTTCCTGGACTTTATAGAAC	0.413										HNSCC(10;0.0054)			11	56	---	---	---	---	PASS
MRPL18	29074	broad.mit.edu	37	6	160218358	160218358	+	Silent	SNP	T	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr6:160218358T>C	uc003qsw.3	+	3	407	c.279T>C	c.(277-279)CTT>CTC	p.L93L	MRPL18_uc010kkb.2_RNA|PNLDC1_uc003qsx.1_5'Flank|PNLDC1_uc003qsy.1_5'Flank	NM_014161	NP_054880	Q9H0U6	RM18_HUMAN	mitochondrial ribosomal protein L18 precursor	93					rRNA transport|translation	mitochondrial ribosome	5S rRNA binding|structural constituent of ribosome				0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.44e-18)|BRCA - Breast invasive adenocarcinoma(81;5.79e-06)		TAGAAGCACTTGTGGAGCATC	0.413													23	30	---	---	---	---	PASS
UNC93A	54346	broad.mit.edu	37	6	167728822	167728822	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr6:167728822G>A	uc003qvq.2	+	8	1431	c.1256G>A	c.(1255-1257)AGC>AAC	p.S419N	UNC93A_uc003qvr.2_Missense_Mutation_p.S377N	NM_018974	NP_061847	Q86WB7	UN93A_HUMAN	unc-93 homolog A isoform 1	419						integral to membrane|plasma membrane					0		Breast(66;7.62e-05)|Ovarian(120;0.105)		OV - Ovarian serous cystadenocarcinoma(33;2.22e-20)|BRCA - Breast invasive adenocarcinoma(81;6.17e-07)|GBM - Glioblastoma multiforme(31;0.00492)		GGGGTCCTGAGCCTGACCATG	0.577													5	306	---	---	---	---	PASS
GPR141	353345	broad.mit.edu	37	7	37780147	37780147	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr7:37780147C>A	uc003tfm.1	+	1	152	c.152C>A	c.(151-153)ACC>AAC	p.T51N	uc003tfl.2_Intron	NM_181791	NP_861456	Q7Z602	GP141_HUMAN	G protein-coupled receptor 141	51	Helical; Name=2; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)	3						CGGTCAGTGACCACCATGGCG	0.498													6	157	---	---	---	---	PASS
SFRP4	6424	broad.mit.edu	37	7	37956067	37956067	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr7:37956067C>T	uc003tfo.3	-	1	459	c.73G>A	c.(73-75)GAG>AAG	p.E25K		NM_003014	NP_003005	Q6FHJ7	SFRP4_HUMAN	secreted frizzled-related  protein 4 precursor	25	FZ.				brain development|cell differentiation|decidualization|embryo development|epithelium development|gonad development|mammary gland involution|menstrual cycle phase|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell proliferation|negative regulation of JNK cascade|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of sodium-dependent phosphate transport|phosphate ion homeostasis|positive regulation of apoptosis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epidermal cell differentiation|positive regulation of gene expression|positive regulation of receptor internalization|vasculature development|Wnt receptor signaling pathway	cell surface|cytoplasm|extracellular space|nucleus	PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(1)	1						CGCACCGCCTCGCAGGGCGCG	0.687													47	50	---	---	---	---	PASS
OGDH	4967	broad.mit.edu	37	7	44747291	44747291	+	Silent	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr7:44747291G>T	uc003tln.2	+	22	3016	c.2907G>T	c.(2905-2907)GTG>GTT	p.V969V	OGDH_uc011kbx.1_Silent_p.V965V|OGDH_uc011kby.1_Silent_p.V819V|OGDH_uc003tlp.2_Silent_p.V980V|OGDH_uc011kbz.1_Silent_p.V764V	NM_002541	NP_002532	Q02218	ODO1_HUMAN	oxoglutarate dehydrogenase isoform 1 precursor	969					glycolysis|lysine catabolic process|tricarboxylic acid cycle	mitochondrial matrix|mitochondrial membrane	oxoglutarate dehydrogenase (succinyl-transferring) activity|thiamine pyrophosphate binding			upper_aerodigestive_tract(1)|ovary(1)	2					NADH(DB00157)	ATGACTACGTGAAGCCAAGAC	0.602													37	142	---	---	---	---	PASS
ZPBP	11055	broad.mit.edu	37	7	50097646	50097646	+	Silent	SNP	G	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr7:50097646G>C	uc003tou.2	-	4	496	c.426C>G	c.(424-426)CTC>CTG	p.L142L	ZPBP_uc011kci.1_Silent_p.L68L|ZPBP_uc010kyw.2_Silent_p.L141L	NM_007009	NP_008940	Q9BS86	ZPBP1_HUMAN	zona pellucida binding protein isoform 1	142					binding of sperm to zona pellucida	extracellular region					0	Glioma(55;0.08)|all_neural(89;0.245)					GTTTATATTCGAGGAAACATG	0.323													6	170	---	---	---	---	PASS
POM121L12	285877	broad.mit.edu	37	7	53104039	53104039	+	Silent	SNP	G	T	T	rs114283332	by1000genomes	TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr7:53104039G>T	uc003tpz.2	+	1	691	c.675G>T	c.(673-675)GCG>GCT	p.A225A		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	225											0						AAAATGGAGCGGTTGCTTCCT	0.637													34	87	---	---	---	---	PASS
CALN1	83698	broad.mit.edu	37	7	71743678	71743678	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr7:71743678C>A	uc003twa.3	-	2	638	c.111G>T	c.(109-111)GAG>GAT	p.E37D	CALN1_uc003twb.3_Missense_Mutation_p.E79D|CALN1_uc003twc.3_Missense_Mutation_p.E37D	NM_001017440	NP_001017440	Q9BXU9	CABP8_HUMAN	calneuron 1 isoform 2	37	EF-hand 1.|Cytoplasmic (Potential).					Golgi apparatus|integral to membrane|perinuclear region of cytoplasm|plasma membrane	calcium ion binding			skin(1)	1		all_cancers(73;0.069)|Lung NSC(55;0.0658)|all_lung(88;0.0912)|all_epithelial(88;0.161)				TACCATCGAGCTCCTCCACGG	0.562													33	41	---	---	---	---	PASS
GTF2IRD1	9569	broad.mit.edu	37	7	73944172	73944172	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr7:73944172G>A	uc003uaq.2	+	9	1592	c.1199G>A	c.(1198-1200)CGC>CAC	p.R400H	GTF2IRD1_uc010lbq.2_Missense_Mutation_p.R432H|GTF2IRD1_uc003uap.2_Missense_Mutation_p.R400H|GTF2IRD1_uc003uar.1_Missense_Mutation_p.R400H	NM_016328	NP_057412	Q9UHL9	GT2D1_HUMAN	GTF2I repeat domain containing 1 isoform 1	400	GTF2I-like 2.					nucleus	DNA binding|protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity			ovary(4)	4						CCCTTCAAGCGCCCCTGCACT	0.562													10	51	---	---	---	---	PASS
TRRAP	8295	broad.mit.edu	37	7	98580986	98580986	+	Missense_Mutation	SNP	A	G	G			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr7:98580986A>G	uc003upp.2	+	59	9114	c.8905A>G	c.(8905-8907)ACG>GCG	p.T2969A	TRRAP_uc011kis.1_Missense_Mutation_p.T2951A|TRRAP_uc003upr.2_Missense_Mutation_p.T2668A	NM_003496	NP_003487	Q9Y4A5	TRRAP_HUMAN	transformation/transcription domain-associated	2969	FAT.				histone deubiquitination|histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	NuA4 histone acetyltransferase complex|PCAF complex|STAGA complex|transcription factor TFTC complex	phosphotransferase activity, alcohol group as acceptor|protein binding|transcription cofactor activity			ovary(9)|large_intestine(8)|central_nervous_system(6)|skin(6)|stomach(5)|upper_aerodigestive_tract(1)|lung(1)|liver(1)	37	all_cancers(62;6.96e-09)|all_epithelial(64;4.86e-09)|Lung NSC(181;0.01)|all_lung(186;0.016)|Esophageal squamous(72;0.0274)		STAD - Stomach adenocarcinoma(171;0.215)			CGACATGAAGACGGTGGTGAA	0.522													31	58	---	---	---	---	PASS
SLC12A9	56996	broad.mit.edu	37	7	100454632	100454632	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr7:100454632C>A	uc003uwp.2	+	5	733	c.591C>A	c.(589-591)TTC>TTA	p.F197L	SLC12A9_uc003uwo.1_Missense_Mutation_p.F108L|SLC12A9_uc003uwq.2_Missense_Mutation_p.F108L|SLC12A9_uc011kki.1_Intron|SLC12A9_uc003uwr.2_5'UTR|SLC12A9_uc003uws.2_5'UTR|SLC12A9_uc003uwt.2_5'UTR|SLC12A9_uc003uwv.2_5'Flank	NM_020246	NP_064631	Q9BXP2	S12A9_HUMAN	solute carrier family 12 (potassium/chloride	197	Helical; (Potential).					integral to membrane|plasma membrane	cation:chloride symporter activity				0	Lung NSC(181;0.041)|all_lung(186;0.0581)					TCCTCACATTCCTGCTGGTCT	0.642													43	110	---	---	---	---	PASS
PRKAR2B	5577	broad.mit.edu	37	7	106710740	106710740	+	Nonsense_Mutation	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr7:106710740C>T	uc003vdx.2	+	2	497	c.322C>T	c.(322-324)CGA>TGA	p.R108*		NM_002736	NP_002727	P31323	KAP3_HUMAN	cAMP-dependent protein kinase, regulatory	108	Dimerization and phosphorylation.				activation of phospholipase C activity|activation of protein kinase A activity|blood coagulation|cellular response to glucagon stimulus|energy reserve metabolic process|G2/M transition of mitotic cell cycle|intracellular signal transduction|nerve growth factor receptor signaling pathway|regulation of insulin secretion|transmembrane transport|water transport	centrosome|cytosol|plasma membrane	cAMP binding|cAMP-dependent protein kinase regulator activity			ovary(1)	1						AGTAATAAACCGATTCACAAG	0.308													34	85	---	---	---	---	PASS
IMMP2L	83943	broad.mit.edu	37	7	110303734	110303734	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr7:110303734C>A	uc003vfq.1	-	6	895	c.452G>T	c.(451-453)TGG>TTG	p.W151L	IMMP2L_uc010ljr.1_Missense_Mutation_p.W151L	NM_032549	NP_115938	Q96T52	IMP2L_HUMAN	IMP2 inner mitochondrial membrane protease-like	151					protein processing involved in protein targeting to mitochondrion|proteolysis	integral to membrane|mitochondrial inner membrane peptidase complex|nucleus	serine-type peptidase activity				0				UCEC - Uterine corpus endometrioid carcinoma (4;0.053)|Epithelial(3;2.27e-07)|all cancers(3;1.36e-05)|STAD - Stomach adenocarcinoma(3;0.00148)|KIRC - Kidney renal clear cell carcinoma(11;0.0339)|Lung(3;0.0375)|Kidney(11;0.0415)|LUSC - Lung squamous cell carcinoma(290;0.173)		CTCTGGGGGCCACAGGATATG	0.438													29	67	---	---	---	---	PASS
KIAA1549	57670	broad.mit.edu	37	7	138604033	138604033	+	Silent	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr7:138604033C>T	uc011kql.1	-	2	388	c.339G>A	c.(337-339)CCG>CCA	p.P113P	KIAA1549_uc003vuk.3_Silent_p.P63P|KIAA1549_uc011kqj.1_Silent_p.P113P	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	113						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						TAGTGGCAGACGGCGGGGCTG	0.517			O	BRAF	pilocytic astrocytoma								17	108	---	---	---	---	PASS
HIPK2	28996	broad.mit.edu	37	7	139257806	139257806	+	Nonsense_Mutation	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr7:139257806G>T	uc003vvf.3	-	15	3638	c.3464C>A	c.(3463-3465)TCG>TAG	p.S1155*	HIPK2_uc003vvd.3_Nonsense_Mutation_p.S1128*	NM_022740	NP_073577	Q9H2X6	HIPK2_HUMAN	homeodomain interacting protein kinase 2 isoform	1155	Autoinhibitory domain (AID).				apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|negative regulation of BMP signaling pathway|positive regulation of JNK cascade|positive regulation of transforming growth factor beta receptor signaling pathway|SMAD protein signal transduction|transcription, DNA-dependent|virus-host interaction	centrosome|nuclear membrane|PML body	ATP binding|protein serine/threonine kinase activity|SMAD binding|transcription corepressor activity|virion binding			ovary(3)|central_nervous_system(3)|skin(1)	7	Melanoma(164;0.205)					GATGGTGGGCGAGGGCAGGAC	0.662													8	10	---	---	---	---	PASS
DENND2A	27147	broad.mit.edu	37	7	140259565	140259565	+	Missense_Mutation	SNP	A	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr7:140259565A>C	uc010lnj.2	-	8	1977	c.1832T>G	c.(1831-1833)ATT>AGT	p.I611S	DENND2A_uc011kre.1_RNA|DENND2A_uc010lnk.2_Missense_Mutation_p.I611S|DENND2A_uc003vvw.2_Missense_Mutation_p.I611S|DENND2A_uc003vvx.2_Missense_Mutation_p.I611S	NM_015689	NP_056504	Q9ULE3	DEN2A_HUMAN	DENN/MADD domain containing 2A	611	UDENN.									ovary(3)|breast(1)	4	Melanoma(164;0.00956)					GAACTGGGGAATGGCCTTCAG	0.512													10	41	---	---	---	---	PASS
CNTNAP2	26047	broad.mit.edu	37	7	146741040	146741040	+	Silent	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr7:146741040C>T	uc003weu.1	+	4	960	c.444C>T	c.(442-444)CAC>CAT	p.H148H		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	148	F5/8 type C.|Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			TGGTCCGGCACGAATTACAGC	0.423										HNSCC(39;0.1)			18	150	---	---	---	---	PASS
MLL3	58508	broad.mit.edu	37	7	151891602	151891602	+	Missense_Mutation	SNP	T	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr7:151891602T>C	uc003wla.2	-	29	4649	c.4430A>G	c.(4429-4431)AAT>AGT	p.N1477S	MLL3_uc003wkz.2_Missense_Mutation_p.N538S	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1477					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TGAACTCTGATTGACATTTGG	0.388			N		medulloblastoma								72	53	---	---	---	---	PASS
ZNF596	169270	broad.mit.edu	37	8	196171	196171	+	Missense_Mutation	SNP	A	G	G			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr8:196171A>G	uc003wot.2	+	6	1612	c.1324A>G	c.(1324-1326)ACT>GCT	p.T442A	ZNF596_uc003wou.2_Missense_Mutation_p.T341A|ZNF596_uc003wov.2_Missense_Mutation_p.T442A|ZNF596_uc003wow.2_Missense_Mutation_p.T442A	NM_173539	NP_775810	Q8TC21	ZN596_HUMAN	zinc finger protein 596	442					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(2;4.81e-29)|all_epithelial(2;5.03e-19)|Lung NSC(2;8.68e-08)|all_lung(2;1.52e-07)|Ovarian(12;0.00965)|Colorectal(14;0.0367)|all_neural(12;0.0837)|Myeloproliferative disorder(644;0.116)|all_hematologic(2;0.138)|Acute lymphoblastic leukemia(644;0.242)		Epithelial(5;3.77e-18)|all cancers(2;5.2e-17)|OV - Ovarian serous cystadenocarcinoma(5;5.37e-09)|BRCA - Breast invasive adenocarcinoma(11;1.7e-06)|Colorectal(2;6.51e-05)|READ - Rectum adenocarcinoma(2;0.0276)|COAD - Colon adenocarcinoma(149;0.0702)		GAGAACTCACACTGGAGAGAA	0.393													14	47	---	---	---	---	PASS
MYOM2	9172	broad.mit.edu	37	8	2020527	2020527	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr8:2020527G>T	uc003wpx.3	+	9	1034	c.896G>T	c.(895-897)TGC>TTC	p.C299F	MYOM2_uc011kwi.1_Intron	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	299	Ig-like C2-type 2.				muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		ACTCTCAAGTGCACCATGCTG	0.622													14	23	---	---	---	---	PASS
CSMD1	64478	broad.mit.edu	37	8	2964165	2964165	+	Splice_Site	SNP	T	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr8:2964165T>C	uc011kwk.1	-	46	7229	c.6839_splice	c.e46-1	p.G2280_splice	CSMD1_uc011kwj.1_Splice_Site_p.G1672_splice|CSMD1_uc010lrg.2_Splice_Site_p.G348_splice	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor							integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		CAAAATCTCCTAGAAGAGTCA	0.463													6	23	---	---	---	---	PASS
GATA4	2626	broad.mit.edu	37	8	11607646	11607646	+	Silent	SNP	C	G	G			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr8:11607646C>G	uc003wuc.2	+	4	1364	c.810C>G	c.(808-810)TCC>TCG	p.S270S	GATA4_uc003wub.1_Silent_p.S64S|GATA4_uc011kxc.1_Silent_p.S271S	NM_002052	NP_002043	P43694	GATA4_HUMAN	GATA binding protein 4	270					atrial septum primum morphogenesis|atrial septum secundum morphogenesis|blood coagulation|cardiac right ventricle morphogenesis|cell-cell signaling|embryonic foregut morphogenesis|embryonic heart tube anterior/posterior pattern formation|endocardial cushion development|endoderm development|heart looping|intestinal epithelial cell differentiation|male gonad development|positive regulation of angiogenesis|positive regulation of cardioblast differentiation|positive regulation of transcription from RNA polymerase II promoter|positive regulation vascular endothelial growth factor production|response to drug|transcription from RNA polymerase II promoter|ventricular septum development	nucleoplasm	activating transcription factor binding|sequence-specific DNA binding|transcription regulatory region DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(15;0.0839)		STAD - Stomach adenocarcinoma(15;0.00225)	COAD - Colon adenocarcinoma(149;0.199)		TGGGCCTCTCCTGTGCCAACT	0.627													9	32	---	---	---	---	PASS
PNMA2	10687	broad.mit.edu	37	8	26365833	26365833	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr8:26365833C>T	uc003xez.2	-	3	1209	c.439G>A	c.(439-441)GGA>AGA	p.G147R		NM_007257	NP_009188	Q9UL42	PNMA2_HUMAN	paraneoplastic antigen MA2	147					apoptosis	nucleolus	protein binding				0		all_cancers(63;0.109)|Ovarian(32;2.61e-05)|all_epithelial(46;0.105)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0196)|Epithelial(17;3.13e-11)|Colorectal(74;0.123)		attgcctgtcccaacaaatgg	0.000													5	56	---	---	---	---	PASS
PCMTD1	115294	broad.mit.edu	37	8	52732941	52732941	+	Missense_Mutation	SNP	T	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr8:52732941T>A	uc003xqx.3	-	6	1385	c.1044A>T	c.(1042-1044)AAA>AAT	p.K348N	PCMTD1_uc011ldm.1_Missense_Mutation_p.K218N|PCMTD1_uc003xqw.3_Missense_Mutation_p.K348N|PCMTD1_uc011ldn.1_Missense_Mutation_p.K160N|PCMTD1_uc010lya.2_Missense_Mutation_p.K272N	NM_052937	NP_443169	Q96MG8	PCMD1_HUMAN	protein-L-isoaspartate (D-aspartate)	348						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity				0		Lung NSC(129;0.0795)|all_lung(136;0.144)				TCAAGTAAGCTTTTAAAGATT	0.328													3	66	---	---	---	---	PASS
CHD7	55636	broad.mit.edu	37	8	61735246	61735246	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr8:61735246G>T	uc003xue.2	+	12	3619	c.3142G>T	c.(3142-3144)GGG>TGG	p.G1048W	CHD7_uc003xuf.2_Missense_Mutation_p.G161W	NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	1048	Helicase ATP-binding.				central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			TGTGTATCATGGGAGTCAAGC	0.448													60	116	---	---	---	---	PASS
CHD7	55636	broad.mit.edu	37	8	61774820	61774820	+	Silent	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr8:61774820C>T	uc003xue.2	+	36	8373	c.7896C>T	c.(7894-7896)AAC>AAT	p.N2632N		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2632					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			GATGTCGAAACCCTAATAAAT	0.363													4	14	---	---	---	---	PASS
PI15	51050	broad.mit.edu	37	8	75737636	75737636	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr8:75737636C>T	uc003yal.2	+	2	331	c.152C>T	c.(151-153)GCG>GTG	p.A51V	uc003yak.1_Intron|PI15_uc003yam.2_Missense_Mutation_p.A51V	NM_015886	NP_056970	O43692	PI15_HUMAN	protease inhibitor 15 preproprotein	51						extracellular region	peptidase inhibitor activity			central_nervous_system(2)|ovary(1)	3	Breast(64;0.137)		BRCA - Breast invasive adenocarcinoma(89;0.104)|Epithelial(68;0.118)			TTAGATTCAGCGGATATCCCC	0.468													26	55	---	---	---	---	PASS
RIMS2	9699	broad.mit.edu	37	8	105263326	105263326	+	Missense_Mutation	SNP	A	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr8:105263326A>T	uc003yls.2	+	27	4061	c.3820A>T	c.(3820-3822)ACG>TCG	p.T1274S	RIMS2_uc003ylp.2_Missense_Mutation_p.T1256S|RIMS2_uc003ylw.2_Missense_Mutation_p.T1263S|RIMS2_uc003ylq.2_Missense_Mutation_p.T1070S|RIMS2_uc003ylr.2_Missense_Mutation_p.T1095S	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1318	C2 2.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			GGCAAGAAAAACGCTGGAACC	0.378										HNSCC(12;0.0054)			21	38	---	---	---	---	PASS
TM7SF4	81501	broad.mit.edu	37	8	105361446	105361446	+	Silent	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr8:105361446C>A	uc003ylx.1	+	2	715	c.666C>A	c.(664-666)CTC>CTA	p.L222L		NM_030788	NP_110415	Q9H295	TM7S4_HUMAN	dendritic cell-specific transmembrane protein	222	Helical; (Potential).				osteoclast differentiation	cell surface|integral to membrane|plasma membrane				pancreas(2)|large_intestine(1)|ovary(1)	4			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			GGCTTTCGCTCGTCCTGCTTG	0.502													65	103	---	---	---	---	PASS
CSMD3	114788	broad.mit.edu	37	8	113256633	113256633	+	Silent	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr8:113256633G>T	uc003ynu.2	-	65	10551	c.10392C>A	c.(10390-10392)CCC>CCA	p.P3464P	CSMD3_uc003yns.2_Silent_p.P2666P|CSMD3_uc003ynt.2_Silent_p.P3424P|CSMD3_uc011lhx.1_Silent_p.P3295P	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3464	Extracellular (Potential).|Sushi 28.					integral to membrane|plasma membrane		p.P3464S(1)		ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CTTCACAAATGGGAACTTTTC	0.348										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			24	85	---	---	---	---	PASS
CSMD3	114788	broad.mit.edu	37	8	113569047	113569047	+	Silent	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr8:113569047G>A	uc003ynu.2	-	25	4338	c.4179C>T	c.(4177-4179)CTC>CTT	p.L1393L	CSMD3_uc003yns.2_Silent_p.L665L|CSMD3_uc003ynt.2_Silent_p.L1353L|CSMD3_uc011lhx.1_Silent_p.L1289L	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1393	Extracellular (Potential).|Sushi 7.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						TCATGCACTTGAGAAGGCTAC	0.448										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			25	69	---	---	---	---	PASS
TRPS1	7227	broad.mit.edu	37	8	116599281	116599281	+	Missense_Mutation	SNP	A	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr8:116599281A>T	uc003ynz.2	-	4	3067	c.2608T>A	c.(2608-2610)TAT>AAT	p.Y870N	TRPS1_uc011lhy.1_Missense_Mutation_p.Y874N|TRPS1_uc003yny.2_Missense_Mutation_p.Y883N|TRPS1_uc010mcy.2_Missense_Mutation_p.Y870N	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	870					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			GATGCAGGATACTGCTGGGGG	0.517									Langer-Giedion_syndrome				51	80	---	---	---	---	PASS
NSMCE2	286053	broad.mit.edu	37	8	126369499	126369499	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr8:126369499G>A	uc003yrw.2	+	6	685	c.457G>A	c.(457-459)GGA>AGA	p.G153R		NM_173685	NP_775956	Q96MF7	NSE2_HUMAN	non-SMC element 2, MMS21 homolog	153					DNA recombination|DNA repair	nucleus	ligase activity|zinc ion binding			breast(1)	1	Ovarian(258;0.0028)|all_neural(195;0.00294)|Hepatocellular(40;0.108)		STAD - Stomach adenocarcinoma(47;0.000918)			CGGAACAGAAGGAGTGGATGA	0.458													33	58	---	---	---	---	PASS
FAM135B	51059	broad.mit.edu	37	8	139163694	139163694	+	Silent	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr8:139163694G>T	uc003yuy.2	-	13	3195	c.3024C>A	c.(3022-3024)TCC>TCA	p.S1008S	FAM135B_uc003yux.2_Silent_p.S909S|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Silent_p.S570S|FAM135B_uc003yvb.2_Silent_p.S570S	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	1008										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			ACCCCATGATGGAAGTGCCTG	0.522										HNSCC(54;0.14)			27	51	---	---	---	---	PASS
FAM135B	51059	broad.mit.edu	37	8	139207519	139207519	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr8:139207519C>A	uc003yuy.2	-	9	1026	c.855G>T	c.(853-855)CAG>CAT	p.Q285H	FAM135B_uc003yux.2_Missense_Mutation_p.Q186H|FAM135B_uc003yuz.2_RNA	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	285										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			CTGAGCACAGCTGAGAAAGTG	0.418										HNSCC(54;0.14)			34	100	---	---	---	---	PASS
LRRC14	9684	broad.mit.edu	37	8	145746733	145746733	+	Silent	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr8:145746733C>T	uc003zdk.1	+	4	1499	c.1353C>T	c.(1351-1353)TCC>TCT	p.S451S	LRRC14_uc003zdl.1_Silent_p.S451S|LRRC14_uc003zdo.2_5'Flank	NM_014665	NP_055480	Q15048	LRC14_HUMAN	leucine rich repeat containing 14	451											0	all_cancers(97;5.56e-11)|all_epithelial(106;3.54e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;1.48e-41)|Epithelial(56;1.85e-40)|all cancers(56;3.59e-35)|BRCA - Breast invasive adenocarcinoma(115;0.0483)|Colorectal(110;0.055)			TGGAGGCCTCCATCAATGAGG	0.627													8	35	---	---	---	---	PASS
FREM1	158326	broad.mit.edu	37	9	14824964	14824964	+	Silent	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr9:14824964C>A	uc003zlm.2	-	11	2498	c.1908G>T	c.(1906-1908)GTG>GTT	p.V636V	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	636	CSPG 4.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		GCTGGTCATCCACTGGAGTTA	0.388													45	26	---	---	---	---	PASS
ZCCHC7	84186	broad.mit.edu	37	9	37356933	37356933	+	Missense_Mutation	SNP	T	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr9:37356933T>C	uc003zzq.2	+	9	1473	c.1300T>C	c.(1300-1302)TGG>CGG	p.W434R	ZCCHC7_uc011lqh.1_Missense_Mutation_p.W144R|ZCCHC7_uc011lqi.1_Missense_Mutation_p.W433R|ZCCHC7_uc010mlt.2_Missense_Mutation_p.W433R	NM_032226	NP_115602	Q8N3Z6	ZCHC7_HUMAN	zinc finger, CCHC domain containing 7	434							nucleic acid binding|zinc ion binding			ovary(1)|central_nervous_system(1)|skin(1)	3				GBM - Glioblastoma multiforme(29;0.0137)		CCGTGCCTCATGGAAAAGCAA	0.433													23	17	---	---	---	---	PASS
FRMPD1	22844	broad.mit.edu	37	9	37745120	37745120	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr9:37745120C>A	uc004aag.1	+	16	3135	c.3091C>A	c.(3091-3093)CCA>ACA	p.P1031T	FRMPD1_uc004aah.1_Missense_Mutation_p.P1031T	NM_014907	NP_055722	Q5SYB0	FRPD1_HUMAN	FERM and PDZ domain containing 1	1031						cytoskeleton|cytosol|plasma membrane				ovary(4)|central_nervous_system(2)|skin(2)|breast(1)	9				GBM - Glioblastoma multiforme(29;0.00655)		GGCCAGCAACCCAGGACTAAA	0.502													51	69	---	---	---	---	PASS
C9orf125	84302	broad.mit.edu	37	9	104238559	104238559	+	Silent	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr9:104238559C>A	uc004bbm.2	-	2	1138	c.816G>T	c.(814-816)CTG>CTT	p.L272L	uc004bbl.1_5'Flank	NM_032342	NP_115718	Q9BRR3	CI125_HUMAN	hypothetical protein LOC84302	272	Helical; (Potential).					integral to membrane					0		Acute lymphoblastic leukemia(62;0.0527)				GTAAGGGCCCCAGCAACATGC	0.537													113	61	---	---	---	---	PASS
ZFP37	7539	broad.mit.edu	37	9	115818955	115818955	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr9:115818955C>T	uc004bgm.1	-	1	42	c.14G>A	c.(13-15)AGC>AAC	p.S5N	ZFP37_uc011lwz.1_Missense_Mutation_p.S5N|ZFP37_uc011lxa.1_Missense_Mutation_p.S5N	NM_003408	NP_003399	Q9Y6Q3	ZFP37_HUMAN	zinc finger protein 37 homolog	5						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						CTGGACGCCGCTGGAGACCGA	0.672													40	32	---	---	---	---	PASS
TLR4	7099	broad.mit.edu	37	9	120475457	120475457	+	Nonsense_Mutation	SNP	A	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr9:120475457A>T	uc004bjz.2	+	3	1342	c.1051A>T	c.(1051-1053)AAA>TAA	p.K351*	TLR4_uc004bka.2_Nonsense_Mutation_p.K311*|TLR4_uc004bkb.2_Nonsense_Mutation_p.K151*	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	351	LRR 9.|Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						ATTGAAACTCAAATCTCTCAA	0.353													48	41	---	---	---	---	PASS
OR1J4	26219	broad.mit.edu	37	9	125281783	125281783	+	Missense_Mutation	SNP	C	G	G			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr9:125281783C>G	uc011lyw.1	+	1	364	c.364C>G	c.(364-366)CGG>GGG	p.R122G		NM_001004452	NP_001004452	Q8NGS1	OR1J4_HUMAN	olfactory receptor, family 1, subfamily J,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						GGCATACGATCGGTATGTGGC	0.433													94	71	---	---	---	---	PASS
OR1N2	138882	broad.mit.edu	37	9	125315489	125315489	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr9:125315489G>T	uc011lyx.1	+	1	41	c.41G>T	c.(40-42)GGG>GTG	p.G14V		NM_001004457	NP_001004457	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N,	14	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4						GAACTACAAGGGATGGGAAAA	0.368													71	35	---	---	---	---	PASS
STXBP1	6812	broad.mit.edu	37	9	130430389	130430389	+	Silent	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr9:130430389G>T	uc004brl.2	+	10	1022	c.825G>T	c.(823-825)CGG>CGT	p.R275R	STXBP1_uc004brk.2_Silent_p.R275R	NM_001032221	NP_001027392	P61764	STXB1_HUMAN	syntaxin binding protein 1 isoform b	275					axon target recognition|energy reserve metabolic process|glutamate secretion|negative regulation of synaptic transmission, GABAergic|neurotransmitter secretion|platelet aggregation|platelet degranulation|protein transport|regulation of insulin secretion|regulation of synaptic vesicle priming|synaptic vesicle maturation|vesicle docking involved in exocytosis	cytosol|mitochondrion|plasma membrane|platelet alpha granule|protein complex	identical protein binding|syntaxin-1 binding|syntaxin-2 binding			skin(1)	1						GGGAGGCACGGGTGAAGGAGG	0.592													4	36	---	---	---	---	PASS
NOTCH1	4851	broad.mit.edu	37	9	139393588	139393588	+	Missense_Mutation	SNP	C	G	G			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr9:139393588C>G	uc004chz.2	-	32	6058	c.6058G>C	c.(6058-6060)GAC>CAC	p.D2020H		NM_017617	NP_060087	P46531	NOTC1_HUMAN	notch1 preproprotein	2020	ANK 3.|Cytoplasmic (Potential).				aortic valve morphogenesis|immune response|negative regulation of BMP signaling pathway|negative regulation of cell-substrate adhesion|negative regulation of myoblast differentiation|negative regulation of osteoblast differentiation|negative regulation of transcription, DNA-dependent|Notch receptor processing	cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to membrane|nucleoplasm|plasma membrane	calcium ion binding|protein binding|receptor activity			haematopoietic_and_lymphoid_tissue(791)|upper_aerodigestive_tract(29)|lung(13)|central_nervous_system(10)|breast(9)|large_intestine(1)|skin(1)|oesophagus(1)|pancreas(1)	856	all_cancers(76;0.223)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.34e-06)|Epithelial(140;7.77e-06)		GCGTTGACGTCGGCGTGTGAG	0.677			T|Mis|O	TRB@	T-ALL					HNSCC(8;0.001)			34	27	---	---	---	---	PASS
FAM107B	83641	broad.mit.edu	37	10	14572388	14572388	+	Missense_Mutation	SNP	A	G	G			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr10:14572388A>G	uc001imx.1	-	2	316	c.71T>C	c.(70-72)GTA>GCA	p.V24A	FAM107B_uc001ina.1_Missense_Mutation_p.V199A|FAM107B_uc010qbu.1_RNA|FAM107B_uc009xjg.1_Missense_Mutation_p.V24A|FAM107B_uc001imy.1_Missense_Mutation_p.V24A|FAM107B_uc001imz.1_Missense_Mutation_p.V24A	NM_031453	NP_113641	Q9H098	F107B_HUMAN	hypothetical protein LOC83641	24										breast(4)	4						GGAGGTTTTTACAGGATTGAT	0.373													3	162	---	---	---	---	PASS
RSU1	6251	broad.mit.edu	37	10	16796963	16796963	+	Nonsense_Mutation	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr10:16796963G>A	uc001iok.2	-	4	609	c.307C>T	c.(307-309)CGA>TGA	p.R103*	RSU1_uc001iol.2_Nonsense_Mutation_p.R103*|RSU1_uc001iom.2_Nonsense_Mutation_p.R50*|RSU1_uc001ion.2_Nonsense_Mutation_p.R103*	NM_152724	NP_689937	Q15404	RSU1_HUMAN	ras suppressor protein 1 isoform 2	103	LRR 3.				cell junction assembly|signal transduction	cytosol	protein binding			central_nervous_system(1)	1				GBM - Glioblastoma multiforme(1;7.54e-08)		CCGAAGCCTCGTGGCAAAGTG	0.468													13	99	---	---	---	---	PASS
CUBN	8029	broad.mit.edu	37	10	16960671	16960671	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr10:16960671C>A	uc001ioo.2	-	45	7002	c.6950G>T	c.(6949-6951)CGA>CTA	p.R2317L		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	2317	CUB 16.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GTTGTCAGATCGAAATCTCAA	0.348													5	45	---	---	---	---	PASS
SLC39A12	221074	broad.mit.edu	37	10	18292099	18292099	+	Splice_Site	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr10:18292099G>T	uc001ipo.2	+	12	2033	c.1760_splice	c.e12-1	p.G587_splice	SLC39A12_uc001ipn.2_Splice_Site_p.G550_splice|SLC39A12_uc001ipp.2_Splice_Site_p.G586_splice|SLC39A12_uc010qck.1_Splice_Site_p.G453_splice|uc001ipq.1_RNA	NM_001145195	NP_001138667	Q504Y0	S39AC_HUMAN	solute carrier family 39 (zinc transporter),						zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			ovary(1)|breast(1)	2						TTAAACTTCAGGAGACTTTGC	0.393													27	130	---	---	---	---	PASS
PTCHD3	374308	broad.mit.edu	37	10	27702888	27702888	+	Nonsense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr10:27702888C>A	uc001itu.2	-	1	410	c.292G>T	c.(292-294)GAG>TAG	p.E98*		NM_001034842	NP_001030014	Q3KNS1	PTHD3_HUMAN	patched domain containing 3	98					spermatid development	integral to membrane	hedgehog receptor activity			ovary(2)|pancreas(1)|skin(1)	4						GTTTCCTCCTCCGGCAGGGGT	0.706													11	18	---	---	---	---	PASS
C10orf71	118461	broad.mit.edu	37	10	50532472	50532472	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr10:50532472G>T	uc010qgp.1	+	3	2221	c.1882G>T	c.(1882-1884)GCC>TCC	p.A628S		NM_199459	NP_955629	Q711Q0	CJ071_HUMAN	hypothetical protein LOC118461 isoform 2	628											0						GATGGGTCCTGCCGGATCCAG	0.572													6	10	---	---	---	---	PASS
ERCC6	2074	broad.mit.edu	37	10	50678601	50678601	+	Silent	SNP	T	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr10:50678601T>C	uc001jhs.3	-	18	3559	c.3405A>G	c.(3403-3405)ACA>ACG	p.T1135T	ERCC6_uc009xod.2_Silent_p.T295T|ERCC6_uc010qgr.1_Silent_p.T505T|ERCC6_uc001jhr.3_Silent_p.T503T	NM_000124	NP_000115	Q03468	ERCC6_HUMAN	excision repair cross-complementing rodent	1135					base-excision repair|positive regulation of transcription elongation, DNA-dependent|transcription from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair	nucleolus|soluble fraction|transcription elongation factor complex	ATP binding|chromatin binding|DNA binding|DNA-dependent ATPase activity|helicase activity|protein C-terminus binding|protein complex binding|protein N-terminus binding			lung(5)|breast(5)|ovary(3)|large_intestine(2)|skin(1)	16						AAGTTTTGCCTGTTCCTGAAG	0.408								Direct_reversal_of_damage|NER					56	77	---	---	---	---	PASS
ANK3	288	broad.mit.edu	37	10	61834414	61834414	+	Silent	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr10:61834414C>T	uc001jky.2	-	37	6417	c.6225G>A	c.(6223-6225)CAG>CAA	p.Q2075Q	ANK3_uc001jkw.2_Intron|ANK3_uc009xpa.2_Intron|ANK3_uc001jkx.2_Intron|ANK3_uc010qih.1_Intron|ANK3_uc001jkz.3_Intron|ANK3_uc001jkv.2_Intron|ANK3_uc009xpb.1_Intron	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	2075					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						GTTTGTGTTCCTGCAAAGCAA	0.393													20	103	---	---	---	---	PASS
TTC18	118491	broad.mit.edu	37	10	75113471	75113471	+	Silent	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr10:75113471G>A	uc009xrc.2	-	3	214	c.93C>T	c.(91-93)ACC>ACT	p.T31T	TTC18_uc001jty.2_Silent_p.T31T|TTC18_uc009xrd.1_5'UTR	NM_145170	NP_660153	Q5T0N1	TTC18_HUMAN	tetratricopeptide repeat domain 18	31							binding			ovary(2)|central_nervous_system(1)	3	Prostate(51;0.0119)					CTCGAATAAAGGTAACTGGAG	0.373													18	38	---	---	---	---	PASS
DLG5	9231	broad.mit.edu	37	10	79552268	79552268	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr10:79552268C>A	uc001jzk.2	-	32	5760	c.5690G>T	c.(5689-5691)TGC>TTC	p.C1897F	DLG5_uc001jzi.2_Missense_Mutation_p.C652F|DLG5_uc001jzj.2_Missense_Mutation_p.C1312F	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	discs large homolog 5	1897	Guanylate kinase-like.				cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			ovary(5)|breast(3)	8	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			GATCTGAGTGCAAATGCTTGA	0.527													4	146	---	---	---	---	PASS
NRG3	10718	broad.mit.edu	37	10	84745221	84745221	+	Nonsense_Mutation	SNP	G	T	T	rs138878772	byFrequency	TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr10:84745221G>T	uc001kco.2	+	9	1978	c.1951G>T	c.(1951-1953)GAA>TAA	p.E651*	NRG3_uc010qlz.1_Nonsense_Mutation_p.E650*|NRG3_uc001kcp.2_Nonsense_Mutation_p.E454*|NRG3_uc001kcq.2_Nonsense_Mutation_p.E301*|NRG3_uc001kcr.2_Nonsense_Mutation_p.E325*	NM_001010848	NP_001010848	P56975	NRG3_HUMAN	neuregulin 3 isoform 1	675	Cytoplasmic (Potential).				regulation of cell growth	extracellular region|integral to plasma membrane	growth factor activity|receptor tyrosine kinase binding|transmembrane receptor protein tyrosine kinase activator activity			lung(5)|breast(1)	6				GBM - Glioblastoma multiforme(1;2.5e-18)|all cancers(1;2.85e-09)		AGAAGACTACGAACTGGCCAG	0.483													4	38	---	---	---	---	PASS
CYP2C8	1558	broad.mit.edu	37	10	96798718	96798718	+	Silent	SNP	A	G	G			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr10:96798718A>G	uc001kkb.2	-	8	1322	c.1227T>C	c.(1225-1227)CCT>CCC	p.P409P	CYP2C8_uc001kkc.2_RNA|CYP2C8_uc010qoa.1_Silent_p.P339P|CYP2C8_uc010qob.1_Silent_p.P323P|CYP2C8_uc010qoc.1_Silent_p.P307P|CYP2C8_uc010qod.1_3'UTR	NM_000770	NP_000761	P10632	CP2C8_HUMAN	cytochrome P450, family 2, subfamily C,	409					exogenous drug catabolic process|organic acid metabolic process|oxidative demethylation|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|caffeine oxidase activity|electron carrier activity|heme binding|oxygen binding				0		Colorectal(252;0.0397)		all cancers(201;6.21e-05)	Aminophenazone(DB01424)|Amiodarone(DB01118)|Amodiaquine(DB00613)|Benzphetamine(DB00865)|Carbamazepine(DB00564)|Cerivastatin(DB00439)|Diclofenac(DB00586)|Fluvastatin(DB01095)|Fosphenytoin(DB01320)|Gemfibrozil(DB01241)|Ketoconazole(DB01026)|Lapatinib(DB01259)|Lovastatin(DB00227)|Midazolam(DB00683)|Montelukast(DB00471)|Nicardipine(DB00622)|Paclitaxel(DB01229)|Phenytoin(DB00252)|Pioglitazone(DB01132)|Repaglinide(DB00912)|Rifampin(DB01045)|Rosiglitazone(DB00412)|Simvastatin(DB00641)|Sitagliptin(DB01261)|Tolbutamide(DB01124)|Torasemide(DB00214)|Tretinoin(DB00755)|Trimethoprim(DB00440)|Warfarin(DB00682)|Zafirlukast(DB00549)|Zopiclone(DB01198)	GAAAGTGGCCAGGGTCAAAGA	0.368													41	59	---	---	---	---	PASS
PDCD11	22984	broad.mit.edu	37	10	105172873	105172873	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr10:105172873G>A	uc001kwy.1	+	9	1066	c.979G>A	c.(979-981)GTG>ATG	p.V327M		NM_014976	NP_055791	Q14690	RRP5_HUMAN	programmed cell death 11	327	S1 motif 3.				mRNA processing|rRNA processing	nucleolus	RNA binding|transcription factor binding			ovary(2)|breast(2)|skin(2)|central_nervous_system(1)	7		Colorectal(252;0.0747)|Breast(234;0.128)		Epithelial(162;7.21e-09)|all cancers(201;1.17e-08)|BRCA - Breast invasive adenocarcinoma(275;0.208)		TTTTGTCTAGGTGAGGGCCTG	0.587													10	73	---	---	---	---	PASS
SLK	9748	broad.mit.edu	37	10	105762780	105762780	+	Missense_Mutation	SNP	A	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr10:105762780A>T	uc001kxo.1	+	9	1878	c.1844A>T	c.(1843-1845)AAA>ATA	p.K615I	SLK_uc001kxp.1_Missense_Mutation_p.K615I	NM_014720	NP_055535	Q9H2G2	SLK_HUMAN	serine/threonine kinase 2	615	Glu-rich.				apoptosis|nucleotide-excision repair	cytoplasm|plasma membrane	ATP binding|DNA binding|nuclease activity|protein serine/threonine kinase activity			ovary(2)|stomach(2)|skin(2)|lung(1)|kidney(1)	8		Colorectal(252;0.178)		Epithelial(162;5.81e-10)|all cancers(201;2.35e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0165)		GAAGAAGGTAAAAATAAGGAA	0.368													7	29	---	---	---	---	PASS
FAM160B1	57700	broad.mit.edu	37	10	116602761	116602761	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr10:116602761G>T	uc001lcb.2	+	6	927	c.592G>T	c.(592-594)GAT>TAT	p.D198Y	FAM160B1_uc001lcc.2_Missense_Mutation_p.D198Y	NM_020940	NP_065991	Q5W0V3	F16B1_HUMAN	hypothetical protein LOC57700 isoform a	198										lung(1)	1						AAAAGGTCAGGATTCCTTGTC	0.378													11	79	---	---	---	---	PASS
MMP21	118856	broad.mit.edu	37	10	127464382	127464382	+	Silent	SNP	G	A	A	rs149511576		TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr10:127464382G>A	uc001liu.2	-	1	9	c.9C>T	c.(7-9)GCC>GCT	p.A3A		NM_147191	NP_671724	Q8N119	MMP21_HUMAN	matrix metalloproteinase 21 preproprotein	3					proteolysis	extracellular matrix	calcium ion binding|metalloendopeptidase activity|zinc ion binding			ovary(2)	2		all_lung(145;0.0096)|Lung NSC(174;0.0145)|Colorectal(57;0.0846)|all_neural(114;0.0936)				AGATGGAGGCGGCGAGCATTG	0.647													7	36	---	---	---	---	PASS
DHX32	55760	broad.mit.edu	37	10	127529443	127529443	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr10:127529443C>A	uc001ljf.1	-	8	2157	c.1666G>T	c.(1666-1668)GAC>TAC	p.D556Y	BCCIP_uc001ljd.3_Intron|DHX32_uc001lje.1_Missense_Mutation_p.D180Y|DHX32_uc001ljg.1_Missense_Mutation_p.D556Y|BCCIP_uc010qui.1_Intron|BCCIP_uc001ljc.3_Intron|BCCIP_uc010quj.1_Intron	NM_018180	NP_060650	Q7L7V1	DHX32_HUMAN	DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 32	556						mitochondrion|nucleus	ATP binding|helicase activity			breast(2)|ovary(1)|lung(1)	4		all_lung(145;0.00751)|Lung NSC(174;0.0115)|Colorectal(57;0.0846)|all_neural(114;0.0936)				AGAGTTGTGTCTTGGTAAGCC	0.423													80	76	---	---	---	---	PASS
TCERG1L	256536	broad.mit.edu	37	10	133058677	133058677	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr10:133058677C>T	uc001lkp.2	-	4	787	c.701G>A	c.(700-702)AGC>AAC	p.S234N	TCERG1L_uc009yax.1_RNA	NM_174937	NP_777597	Q5VWI1	TCRGL_HUMAN	transcription elongation regulator 1-like	234										large_intestine(2)|ovary(2)	4		all_cancers(35;1.22e-10)|all_epithelial(44;2.65e-09)|Lung NSC(174;0.00188)|all_lung(145;0.00307)|Melanoma(40;0.0179)|all_neural(114;0.0424)|Breast(234;0.0743)|Colorectal(57;0.09)		all cancers(32;0.000899)|OV - Ovarian serous cystadenocarcinoma(35;0.0021)|Epithelial(32;0.00276)		ggcggGGCTGCTGGTCACCTT	0.547													2	1	---	---	---	---	PASS
ARNTL	406	broad.mit.edu	37	11	13391207	13391207	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr11:13391207G>A	uc001mkr.2	+	12	1121	c.713G>A	c.(712-714)CGA>CAA	p.R238Q	ARNTL_uc001mko.2_Missense_Mutation_p.R195Q|ARNTL_uc001mkp.2_Missense_Mutation_p.R238Q|ARNTL_uc001mkq.2_Missense_Mutation_p.R238Q|ARNTL_uc001mks.2_Missense_Mutation_p.R195Q|ARNTL_uc001mkt.2_Missense_Mutation_p.R238Q|ARNTL_uc001mku.2_RNA|ARNTL_uc009ygm.1_Missense_Mutation_p.R195Q|ARNTL_uc001mkv.1_Missense_Mutation_p.R195Q|ARNTL_uc001mkw.2_Missense_Mutation_p.R195Q|ARNTL_uc001mkx.2_Missense_Mutation_p.R236Q	NM_001178	NP_001169	O00327	BMAL1_HUMAN	aryl hydrocarbon receptor nuclear	238					circadian rhythm|positive regulation of transcription from RNA polymerase II promoter	transcription factor complex	aryl hydrocarbon receptor binding|DNA binding|Hsp90 protein binding|sequence-specific DNA binding transcription factor activity|signal transducer activity				0				Epithelial(150;0.0243)		GGGCCATCTCGATTATGTTCT	0.453													23	101	---	---	---	---	PASS
SLC6A5	9152	broad.mit.edu	37	11	20625906	20625906	+	Silent	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr11:20625906G>T	uc001mqd.2	+	3	888	c.615G>T	c.(613-615)GTG>GTT	p.V205V	SLC6A5_uc009yic.2_Intron	NM_004211	NP_004202	Q9Y345	SC6A5_HUMAN	solute carrier family 6 (neurotransmitter	205	Helical; Name=1; (Potential).				synaptic transmission	integral to membrane|plasma membrane	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity			ovary(2)|breast(1)|skin(1)	4					Glycine(DB00145)	TGTCCATGGTGGGGTACGCAG	0.607													17	185	---	---	---	---	PASS
ANO5	203859	broad.mit.edu	37	11	22261201	22261201	+	Silent	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr11:22261201C>T	uc001mqi.2	+	9	1166	c.849C>T	c.(847-849)TTC>TTT	p.F283F	ANO5_uc001mqj.2_Silent_p.F282F	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	283	Cytoplasmic (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						TTTCCTATTTCTACAAGGAGC	0.368													21	142	---	---	---	---	PASS
OR4C11	219429	broad.mit.edu	37	11	55371517	55371517	+	Missense_Mutation	SNP	A	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr11:55371517A>C	uc010rii.1	-	1	333	c.333T>G	c.(331-333)TTT>TTG	p.F111L		NM_001004700	NP_001004700	Q6IEV9	OR4CB_HUMAN	olfactory receptor, family 4, subfamily C,	111	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						GAATGAGGACAAAGATCTCCA	0.433													8	98	---	---	---	---	PASS
OR10AG1	282770	broad.mit.edu	37	11	55735200	55735200	+	Missense_Mutation	SNP	G	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr11:55735200G>C	uc010rit.1	-	1	740	c.740C>G	c.(739-741)ACT>AGT	p.T247S		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	247	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.0137)					ATAAGTGATAGTACCTGCTCC	0.383													29	33	---	---	---	---	PASS
OR8J3	81168	broad.mit.edu	37	11	55904834	55904834	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr11:55904834C>A	uc010riz.1	-	1	361	c.361G>T	c.(361-363)GAC>TAC	p.D121Y		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	121	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					ACATAGCGGTCATAGGCCATC	0.498													15	114	---	---	---	---	PASS
OR8K3	219473	broad.mit.edu	37	11	56086669	56086669	+	Missense_Mutation	SNP	T	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr11:56086669T>A	uc010rjf.1	+	1	887	c.887T>A	c.(886-888)GTA>GAA	p.V296E		NM_001005202	NP_001005202	Q8NH51	OR8K3_HUMAN	olfactory receptor, family 8, subfamily K,	296	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)|central_nervous_system(1)	4	Esophageal squamous(21;0.00448)					AACAAAGATGTAAAATATGCC	0.323													29	29	---	---	---	---	PASS
OR8J1	219477	broad.mit.edu	37	11	56127868	56127868	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr11:56127868C>A	uc010rjh.1	+	1	146	c.146C>A	c.(145-147)ACC>AAC	p.T49N		NM_001005205	NP_001005205	Q8NGP2	OR8J1_HUMAN	olfactory receptor, family 8, subfamily J,	49	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					ATCACCCTCACCAGTGTTGAC	0.507													57	59	---	---	---	---	PASS
AHNAK	79026	broad.mit.edu	37	11	62298396	62298396	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr11:62298396C>T	uc001ntl.2	-	5	3793	c.3493G>A	c.(3493-3495)GAA>AAA	p.E1165K	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	1165					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				TCTGGGGCTTCGATGTCCACC	0.552													99	97	---	---	---	---	PASS
SYVN1	84447	broad.mit.edu	37	11	64898161	64898161	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr11:64898161G>A	uc001odb.2	-	11	1170	c.1076C>T	c.(1075-1077)CCC>CTC	p.P359L	SYVN1_uc001odc.2_Missense_Mutation_p.P359L|SYVN1_uc009yqc.2_Missense_Mutation_p.P308L	NM_172230	NP_757385	Q86TM6	SYVN1_HUMAN	synoviolin 1 isoform b	359	Pro-rich.|Cytoplasmic (Potential).				ER-associated protein catabolic process|response to stress	endoplasmic reticulum membrane|integral to membrane|nucleus	acid-amino acid ligase activity|protein binding|zinc ion binding			ovary(1)	1						GAGTGGTGGGGGGTGGGGGGC	0.657													8	10	---	---	---	---	PASS
EFEMP2	30008	broad.mit.edu	37	11	65634506	65634506	+	Silent	SNP	C	T	T	rs3182964		TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr11:65634506C>T	uc001ofy.3	-	11	1409	c.1215G>A	c.(1213-1215)GTG>GTA	p.V405V	EFEMP2_uc001ofz.2_RNA|EFEMP2_uc001oga.2_Intron	NM_016938	NP_058634	O95967	FBLN4_HUMAN	EGF-containing fibulin-like extracellular matrix	405					blood coagulation	basement membrane|membrane	calcium ion binding|extracellular matrix structural constituent|protein binding|transmembrane receptor activity			ovary(1)	1				READ - Rectum adenocarcinoma(159;0.169)		GGGGGCCCGTCACCGGCCGGG	0.607													72	30	---	---	---	---	PASS
MTL5	9633	broad.mit.edu	37	11	68518014	68518014	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr11:68518014C>A	uc001ooc.2	-	2	255	c.115G>T	c.(115-117)GTG>TTG	p.V39L	MTL5_uc001ood.1_Missense_Mutation_p.V39L|MTL5_uc009ysi.1_Missense_Mutation_p.V39L|MTL5_uc001ooe.2_Missense_Mutation_p.V39L	NM_004923	NP_004914	Q9Y4I5	MTL5_HUMAN	metallothionein-like 5, testis-specific isoform	39					cell differentiation|cellular metal ion homeostasis|multicellular organismal development|response to metal ion|spermatogenesis	cytoplasm|nucleus|soluble fraction	metal ion binding			ovary(2)|breast(1)	3	Esophageal squamous(3;4.37e-12)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.185)			TCGTACTTCACGGGGGCCTTC	0.667													14	12	---	---	---	---	PASS
IGHMBP2	3508	broad.mit.edu	37	11	68685319	68685319	+	Missense_Mutation	SNP	C	G	G			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr11:68685319C>G	uc001ook.1	+	7	1130	c.1028C>G	c.(1027-1029)ACT>AGT	p.T343S	IGHMBP2_uc001ooj.1_RNA	NM_002180	NP_002171	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	343	Leu-rich.				cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GAGAGCCTCACTTCGGCAAAC	0.378													98	41	---	---	---	---	PASS
NAALAD2	10003	broad.mit.edu	37	11	89883651	89883651	+	Missense_Mutation	SNP	G	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr11:89883651G>C	uc001pdf.3	+	5	594	c.485G>C	c.(484-486)GGA>GCA	p.G162A	NAALAD2_uc009yvx.2_Missense_Mutation_p.G162A|NAALAD2_uc009yvy.2_Missense_Mutation_p.G162A|NAALAD2_uc001pdd.2_Missense_Mutation_p.G162A|NAALAD2_uc001pde.2_Missense_Mutation_p.G162A	NM_005467	NP_005458	Q9Y3Q0	NALD2_HUMAN	N-acetylated alpha-linked acidic dipeptidase 2	162	Extracellular (Potential).				proteolysis	integral to membrane	carboxypeptidase activity|dipeptidase activity|dipeptidyl-peptidase activity|metal ion binding|metallopeptidase activity|serine-type peptidase activity			pancreas(1)|skin(1)	2		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00556)				TCCCTATAGGGAGATCTTGTA	0.299													64	39	---	---	---	---	PASS
ALKBH8	91801	broad.mit.edu	37	11	107422636	107422636	+	Missense_Mutation	SNP	G	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr11:107422636G>C	uc010rvr.1	-	6	673	c.598C>G	c.(598-600)CTT>GTT	p.L200V	ALKBH8_uc001pjk.2_5'UTR|ALKBH8_uc010rvq.1_Missense_Mutation_p.L63V|ALKBH8_uc009yxp.2_Missense_Mutation_p.L200V|ALKBH8_uc001pjl.2_RNA	NM_138775	NP_620130	Q96BT7	ALKB8_HUMAN	alkB, alkylation repair homolog 8	200					response to DNA damage stimulus	cytosol|nucleus	metal ion binding|nucleotide binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|protein binding|RNA binding|tRNA (uracil) methyltransferase activity				0		Melanoma(852;0.000288)|Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00301)|all_epithelial(67;0.00512)|Breast(348;0.104)		BRCA - Breast invasive adenocarcinoma(274;3.53e-05)|Epithelial(105;0.00029)|all cancers(92;0.00518)		ATGTCAGGAAGACCTACAATG	0.313													37	30	---	---	---	---	PASS
DRD2	1813	broad.mit.edu	37	11	113281606	113281606	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr11:113281606G>T	uc001pnz.2	-	7	1496	c.1175C>A	c.(1174-1176)ACA>AAA	p.T392K	DRD2_uc010rwv.1_Missense_Mutation_p.T391K|DRD2_uc001poa.3_Missense_Mutation_p.T392K|DRD2_uc001pob.3_Missense_Mutation_p.T363K	NM_000795	NP_000786	P14416	DRD2_HUMAN	dopamine receptor D2 isoform long	392	Agonist binding (By similarity).|Helical; Name=6; (By similarity).				activation of phospholipase C activity by dopamine receptor signaling pathway|adenohypophysis development|adult walking behavior|arachidonic acid secretion|axonogenesis|behavioral response to cocaine|behavioral response to ethanol|branching morphogenesis of a nerve|cerebral cortex GABAergic interneuron migration|circadian regulation of gene expression|elevation of cytosolic calcium ion concentration involved in G-protein signaling coupled to IP3 second messenger|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|intracellular protein kinase cascade|negative regulation of blood pressure|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of cell migration|negative regulation of cell proliferation|negative regulation of dopamine receptor signaling pathway|negative regulation of protein kinase B signaling cascade|negative regulation of protein secretion|negative regulation of synaptic transmission, glutamatergic|neurological system process involved in regulation of systemic arterial blood pressure|peristalsis|phosphatidylinositol metabolic process|positive regulation of dopamine uptake|positive regulation of growth hormone secretion|positive regulation of neuroblast proliferation|prepulse inhibition|protein localization|regulation of heart rate|regulation of long-term neuronal synaptic plasticity|regulation of potassium ion transport|regulation of sodium ion transport|regulation of synaptic transmission, GABAergic|release of sequestered calcium ion into cytosol|response to amphetamine|response to drug|response to histamine|response to morphine|sensory perception of smell|synapse assembly|temperature homeostasis|visual learning	integral to plasma membrane	dopamine D2 receptor activity|dopamine receptor activity, coupled via Gi/Go|drug binding|potassium channel regulator activity|protein binding			pancreas(1)|skin(1)	2		all_cancers(61;3.91e-16)|all_epithelial(67;2.95e-09)|Melanoma(852;1.46e-05)|all_hematologic(158;0.00014)|Acute lymphoblastic leukemia(157;0.000977)|Breast(348;0.0101)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Prostate(24;0.0494)		BRCA - Breast invasive adenocarcinoma(274;5.77e-06)|Epithelial(105;6.66e-05)|all cancers(92;0.000307)|OV - Ovarian serous cystadenocarcinoma(223;0.216)	Acetophenazine(DB01063)|Amantadine(DB00915)|Apomorphine(DB00714)|Aripiprazole(DB01238)|Bromocriptine(DB01200)|Buspirone(DB00490)|Cabergoline(DB00248)|Carphenazine(DB01038)|Chlorpromazine(DB00477)|Chlorprothixene(DB01239)|Cinnarizine(DB00568)|Clozapine(DB00363)|Domperidone(DB01184)|Droperidol(DB00450)|Ergotamine(DB00696)|Flupenthixol(DB00875)|Fluphenazine(DB00623)|Fluspirilene(DB04842)|Haloperidol(DB00502)|Levodopa(DB01235)|Lisuride(DB00589)|Loxapine(DB00408)|Mesoridazine(DB00933)|Metoclopramide(DB01233)|Minaprine(DB00805)|Molindone(DB01618)|Olanzapine(DB00334)|Paliperidone(DB01267)|Pergolide(DB01186)|Perphenazine(DB00850)|Pimozide(DB01100)|Pramipexole(DB00413)|Prochlorperazine(DB00433)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Quetiapine(DB01224)|Remoxipride(DB00409)|Risperidone(DB00734)|Ropinirole(DB00268)|Sertindole(DB06144)|Sulpiride(DB00391)|Thiethylperazine(DB00372)|Thioridazine(DB00679)|Tranylcypromine(DB00752)|Trifluoperazine(DB00831)|Triflupromazine(DB00508)|Ziprasidone(DB00246)|Zuclopenthixol(DB01624)	CAGGATGTGTGTGATGAAGAA	0.607													9	76	---	---	---	---	PASS
TECTA	7007	broad.mit.edu	37	11	121016448	121016448	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr11:121016448G>A	uc010rzo.1	+	11	3728	c.3728G>A	c.(3727-3729)CGC>CAC	p.R1243H		NM_005422	NP_005413	O75443	TECTA_HUMAN	tectorin alpha precursor	1243	VWFD 3.				cell-matrix adhesion|sensory perception of sound	anchored to membrane|plasma membrane|proteinaceous extracellular matrix				breast(6)|ovary(2)|skin(2)	10	all_hematologic(175;0.208)	Breast(109;0.000766)|Medulloblastoma(222;0.0427)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;8.04e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.166)		CTGTGTGGCCGCTACAACGGC	0.532													18	89	---	---	---	---	PASS
OR10G9	219870	broad.mit.edu	37	11	123894283	123894283	+	Nonsense_Mutation	SNP	T	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr11:123894283T>A	uc010sad.1	+	1	564	c.564T>A	c.(562-564)TGT>TGA	p.C188*		NM_001001953	NP_001001953	Q8NGN4	O10G9_HUMAN	olfactory receptor, family 10, subfamily G,	188	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0399)		AACTGGCCTGTGCAGACACCT	0.522													24	229	---	---	---	---	PASS
SIAE	54414	broad.mit.edu	37	11	124524593	124524593	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr11:124524593C>T	uc001qan.2	-	4	615	c.502G>A	c.(502-504)GAC>AAC	p.D168N		NM_170601	NP_733746	Q9HAT2	SIAE_HUMAN	sialate O-acetylesterase precursor	168						extracellular region|lysosome	carboxylesterase activity|sialate O-acetylesterase activity				0	all_hematologic(175;0.215)	Breast(109;0.00109)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.63e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0243)		GCAACAAGGTCCTCCAGCTCC	0.502													31	177	---	---	---	---	PASS
PRDM10	56980	broad.mit.edu	37	11	129772364	129772364	+	Missense_Mutation	SNP	T	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr11:129772364T>A	uc001qfm.2	-	22	3559	c.3327A>T	c.(3325-3327)CAA>CAT	p.Q1109H	PRDM10_uc001qfj.2_Missense_Mutation_p.Q1010H|PRDM10_uc001qfk.2_Missense_Mutation_p.Q972H|PRDM10_uc001qfl.2_Missense_Mutation_p.Q1023H|PRDM10_uc010sbx.1_Missense_Mutation_p.Q1019H|PRDM10_uc001qfn.2_Missense_Mutation_p.Q1105H	NM_020228	NP_064613	Q9NQV6	PRD10_HUMAN	PR domain containing 10 isoform 1	1096					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1	all_hematologic(175;0.0537)	Breast(109;0.000496)|Lung NSC(97;0.000693)|all_lung(97;0.00151)|Medulloblastoma(222;0.0425)|all_neural(223;0.0837)		OV - Ovarian serous cystadenocarcinoma(99;0.0174)|Lung(977;0.176)|LUSC - Lung squamous cell carcinoma(976;0.185)		GGGCAGAAGTTTGCTTTTCTT	0.493													15	51	---	---	---	---	PASS
WNK1	65125	broad.mit.edu	37	12	993955	993955	+	Missense_Mutation	SNP	A	G	G			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr12:993955A>G	uc001qio.3	+	19	4492	c.3985A>G	c.(3985-3987)ACA>GCA	p.T1329A	WNK1_uc001qip.3_Missense_Mutation_p.T1082A|WNK1_uc001qir.3_Missense_Mutation_p.T502A	NM_018979	NP_061852	Q9H4A3	WNK1_HUMAN	WNK lysine deficient protein kinase 1	1329					intracellular protein kinase cascade|ion transport|neuron development	cytoplasm	ATP binding|protein binding|protein kinase inhibitor activity|protein serine/threonine kinase activity			stomach(6)|breast(6)|ovary(5)|lung(4)|large_intestine(1)|central_nervous_system(1)	23	all_cancers(10;0.00611)|all_epithelial(11;0.00825)|all_lung(10;0.0331)|Ovarian(42;0.0512)|Lung NSC(10;0.0632)		Epithelial(1;1.74e-08)|all cancers(1;7.04e-08)|OV - Ovarian serous cystadenocarcinoma(31;0.000423)|BRCA - Breast invasive adenocarcinoma(9;0.0149)|Colorectal(1;0.0197)			CTTTAGTCATACAGGACCAAC	0.498													65	53	---	---	---	---	PASS
A2M	2	broad.mit.edu	37	12	9262611	9262611	+	Silent	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr12:9262611G>A	uc001qvk.1	-	6	638	c.525C>T	c.(523-525)ATC>ATT	p.I175I	A2M_uc009zgk.1_Silent_p.I25I	NM_000014	NP_000005	P01023	A2MG_HUMAN	alpha-2-macroglobulin precursor	175					blood coagulation, intrinsic pathway|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|extracellular space|platelet alpha granule lumen	enzyme binding|GTPase activator activity|interleukin-1 binding|interleukin-8 binding|serine-type endopeptidase inhibitor activity|tumor necrosis factor binding			central_nervous_system(4)|skin(1)	5					Bacitracin(DB00626)|Becaplermin(DB00102)	GCCATTGTGCGATGCGATTTC	0.433													99	106	---	---	---	---	PASS
PRB1	5542	broad.mit.edu	37	12	11508439	11508439	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr12:11508439G>T	uc001qzw.1	-	1	86	c.49C>A	c.(49-51)CAG>AAG	p.Q17K	PRB1_uc001qzu.1_Missense_Mutation_p.Q17K|PRB1_uc001qzv.1_Missense_Mutation_p.Q17K	NM_005039	NP_005030	P04280	PRP1_HUMAN	proline-rich protein BstNI subfamily 1 isoform 1	17						extracellular region					0			OV - Ovarian serous cystadenocarcinoma(49;0.185)			TTTAAGTTCTGAGCTGAGCTC	0.517													70	86	---	---	---	---	PASS
ITPR2	3709	broad.mit.edu	37	12	26864171	26864171	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr12:26864171C>T	uc001rhg.2	-	9	1303	c.886G>A	c.(886-888)GCA>ACA	p.A296T		NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	296	Cytoplasmic (Potential).|MIR 4.				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					CACTGTCCTGCACCCCCACGG	0.418													11	123	---	---	---	---	PASS
PDZRN4	29951	broad.mit.edu	37	12	41946553	41946553	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr12:41946553C>A	uc010skn.1	+	6	770	c.702C>A	c.(700-702)AGC>AGA	p.S234R	PDZRN4_uc001rmq.3_Missense_Mutation_p.S175R|PDZRN4_uc009zjz.2_Missense_Mutation_p.S173R|PDZRN4_uc001rmr.2_Missense_Mutation_p.S60R	NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	433	PDZ 2.						ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				TTTATGTCAGCGAGGTAAGAA	0.488													38	37	---	---	---	---	PASS
NCKAP5L	57701	broad.mit.edu	37	12	50190450	50190450	+	Missense_Mutation	SNP	T	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr12:50190450T>C	uc009zlk.2	-	8	1395	c.1193A>G	c.(1192-1194)GAG>GGG	p.E398G	NCKAP5L_uc001rvc.3_5'Flank|NCKAP5L_uc001rvb.2_5'UTR	NM_001037806	NP_001032895	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	394	Pro-rich.									central_nervous_system(1)	1						CCCCTGGCCCTCTGAGGTAGC	0.652													25	19	---	---	---	---	PASS
KRT2	3849	broad.mit.edu	37	12	53038879	53038879	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr12:53038879C>A	uc001sat.2	-	9	1877	c.1844G>T	c.(1843-1845)GGA>GTA	p.G615V		NM_000423	NP_000414	P35908	K22E_HUMAN	keratin 2	615	Tail.				keratinization|keratinocyte activation|keratinocyte migration|keratinocyte proliferation	Golgi apparatus|keratin filament	protein binding|structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.19)		ACCCCCACCTCCAGAGCCATA	0.552													4	152	---	---	---	---	PASS
KRT1	3848	broad.mit.edu	37	12	53071127	53071127	+	Silent	SNP	A	G	G			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr12:53071127A>G	uc001sau.1	-	5	1160	c.1101T>C	c.(1099-1101)GCT>GCC	p.A367A	KRT1_uc001sav.1_Silent_p.A367A	NM_006121	NP_006112	P04264	K2C1_HUMAN	keratin 1	367	Rod.|Coil 2.				complement activation, lectin pathway|epidermis development|fibrinolysis|regulation of angiogenesis|response to oxidative stress	plasma membrane	protein binding|receptor activity|structural constituent of cytoskeleton|sugar binding			ovary(1)|skin(1)	2						ACTCGGCCTCAGCTTTGCTCT	0.507													10	89	---	---	---	---	PASS
ITGA7	3679	broad.mit.edu	37	12	56079052	56079052	+	Silent	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr12:56079052C>T	uc001shh.2	-	25	3436	c.3216G>A	c.(3214-3216)GCG>GCA	p.A1072A	ITGA7_uc001shg.2_Silent_p.A1068A|ITGA7_uc010sps.1_Silent_p.A975A|ITGA7_uc001shf.2_Missense_Mutation_p.R84Q|ITGA7_uc009znw.2_Silent_p.A315A|ITGA7_uc009znx.2_Silent_p.A949A	NM_001144996	NP_001138468	Q13683	ITA7_HUMAN	integrin alpha 7 isoform 1 precursor	1112	Cytoplasmic (Potential).				cell-matrix adhesion|integrin-mediated signaling pathway|muscle organ development|regulation of cell shape	integrin complex	receptor activity			ovary(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	5						CGGGGTGCTTCGCCCGTTTGA	0.607													10	85	---	---	---	---	PASS
NAV3	89795	broad.mit.edu	37	12	78400498	78400498	+	Silent	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr12:78400498C>A	uc001syp.2	+	8	1353	c.1180C>A	c.(1180-1182)CGG>AGG	p.R394R	NAV3_uc001syo.2_Silent_p.R394R	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	394						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						AGTCAATGCCCGGACTGCTTT	0.498										HNSCC(70;0.22)			45	40	---	---	---	---	PASS
C12orf26	84190	broad.mit.edu	37	12	82780745	82780745	+	Silent	SNP	T	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr12:82780745T>C	uc001szq.2	+	2	444	c.423T>C	c.(421-423)ATT>ATC	p.I141I		NM_032230	NP_115606	Q8N6Q8	CL026_HUMAN	hypothetical protein LOC84190	141											0						ACCAGAGAATTGGTATGTCTA	0.333													4	178	---	---	---	---	PASS
SCYL2	55681	broad.mit.edu	37	12	100706354	100706354	+	Missense_Mutation	SNP	G	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr12:100706354G>C	uc001thn.2	+	6	825	c.775G>C	c.(775-777)GTA>CTA	p.V259L	SCYL2_uc009ztw.1_Missense_Mutation_p.V86L|SCYL2_uc001thm.1_Missense_Mutation_p.V259L	NM_017988	NP_060458	Q6P3W7	SCYL2_HUMAN	SCY1-like 2 protein	259	Protein kinase.				endosome to lysosome transport|negative regulation of canonical Wnt receptor signaling pathway|positive regulation of clathrin-mediated endocytosis|positive regulation of receptor internalization	clathrin-coated vesicle|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm	ATP binding|protein kinase activity|receptor binding			lung(3)|ovary(2)|skin(1)	6						TATGTATGCTGTATTTAATAA	0.348													48	43	---	---	---	---	PASS
CCDC62	84660	broad.mit.edu	37	12	123276650	123276650	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr12:123276650G>A	uc001udc.2	+	6	899	c.754G>A	c.(754-756)GAT>AAT	p.D252N	CCDC62_uc010tah.1_RNA|CCDC62_uc001udf.2_Missense_Mutation_p.D252N|CCDC62_uc001ude.2_Intron	NM_201435	NP_958843	Q6P9F0	CCD62_HUMAN	coiled-coil domain containing 62 isoform b	252	Potential.					cytoplasm|nucleus				ovary(2)|large_intestine(1)|pancreas(1)|skin(1)	5	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.51e-06)|Epithelial(86;2.65e-05)|BRCA - Breast invasive adenocarcinoma(302;0.206)		TTGCCTGCACGATGAATTGCT	0.393													5	92	---	---	---	---	PASS
TMEM132D	121256	broad.mit.edu	37	12	129566322	129566322	+	Silent	SNP	A	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr12:129566322A>T	uc009zyl.1	-	7	2233	c.1905T>A	c.(1903-1905)CTT>CTA	p.L635L	TMEM132D_uc001uia.2_Silent_p.L173L	NM_133448	NP_597705	Q14C87	T132D_HUMAN	transmembrane protein 132D precursor	635	Extracellular (Potential).					integral to membrane				ovary(10)|pancreas(2)|upper_aerodigestive_tract(1)|skin(1)	14	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		TGGTCATCCCAAGCTCCTGCC	0.498													8	50	---	---	---	---	PASS
PIWIL1	9271	broad.mit.edu	37	12	130827214	130827214	+	Silent	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr12:130827214C>T	uc001uik.2	+	2	168	c.78C>T	c.(76-78)GCC>GCT	p.A26A	PIWIL1_uc001uij.1_Silent_p.A26A	NM_004764	NP_004755	Q96J94	PIWL1_HUMAN	piwi-like 1	26					gene silencing by RNA|meiosis|multicellular organismal development|regulation of translation|spermatid development	chromatoid body|P granule	mRNA binding|piRNA binding|protein binding			ovary(2)	2	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;3.02e-06)|Epithelial(86;3.85e-05)|all cancers(50;4.65e-05)		GCTCCACTGCCGTGAGTGCTT	0.512													16	15	---	---	---	---	PASS
NOC4L	79050	broad.mit.edu	37	12	132635872	132635872	+	Silent	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr12:132635872C>T	uc001ujz.1	+	11	1073	c.1032C>T	c.(1030-1032)CGC>CGT	p.R344R		NM_024078	NP_076983	Q9BVI4	NOC4L_HUMAN	nucleolar complex associated 4 homolog	344					rRNA processing	integral to membrane|nuclear membrane|nucleolus	protein binding				0	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.2e-08)|Epithelial(86;3.34e-07)|all cancers(50;1.97e-05)		TCAAGTACCGCGCCCGCTTCT	0.657													6	167	---	---	---	---	PASS
TPTE2	93492	broad.mit.edu	37	13	20012295	20012295	+	Splice_Site	SNP	T	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr13:20012295T>C	uc001umd.2	-	15	1185	c.974_splice	c.e15-1	p.G325_splice	TPTE2_uc009zzk.2_Splice_Site|TPTE2_uc009zzl.2_Splice_Site_p.G214_splice|TPTE2_uc001ume.2_Splice_Site_p.G248_splice|TPTE2_uc009zzm.2_Splice_Site|TPTE2_uc010tcm.1_Splice_Site|TPTE2_uc010tcl.1_5'UTR	NM_199254	NP_954863	Q6XPS3	TPTE2_HUMAN	TPTE and PTEN homologous inositol lipid							endoplasmic reticulum membrane|integral to membrane	ion channel activity|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(29;1.23e-20)|all_lung(29;1.97e-20)|all_epithelial(30;5.86e-20)|Lung NSC(5;3.36e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.73e-05)|Epithelial(112;7.42e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.000785)|Lung(94;0.0176)|LUSC - Lung squamous cell carcinoma(192;0.089)		CGGTTCttcctagaaaagaaa	0.234													30	21	---	---	---	---	PASS
ZMYM5	9205	broad.mit.edu	37	13	20412970	20412970	+	Missense_Mutation	SNP	T	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr13:20412970T>C	uc010tcn.1	-	5	1007	c.742A>G	c.(742-744)AAA>GAA	p.K248E	ZMYM5_uc001umm.1_Missense_Mutation_p.K72E|ZMYM5_uc001umn.2_Missense_Mutation_p.K248E|ZMYM5_uc001umo.2_Intron	NM_001142684	NP_001136156	Q9UJ78	ZMYM5_HUMAN	zinc finger protein 237 isoform 3	248						nucleus	zinc ion binding				0		all_cancers(29;2.96e-22)|all_epithelial(30;3.76e-20)|all_lung(29;4.38e-20)|Lung NSC(5;5.8e-17)|Lung SC(185;0.0262)|Ovarian(182;0.162)		all cancers(112;1.61e-05)|Epithelial(112;4.89e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00171)|Lung(94;0.00942)|LUSC - Lung squamous cell carcinoma(192;0.0431)		AAAGGCTTTTTGCAATTTGCA	0.428													43	266	---	---	---	---	PASS
ATP12A	479	broad.mit.edu	37	13	25263440	25263440	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr13:25263440C>T	uc001upp.2	+	5	660	c.473C>T	c.(472-474)ACG>ATG	p.T158M	ATP12A_uc010aaa.2_Missense_Mutation_p.T158M	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	158	Helical; (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	GTCATTTTAACGGGGATCTTT	0.537													13	109	---	---	---	---	PASS
OR11H4	390442	broad.mit.edu	37	14	20711878	20711878	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr14:20711878G>T	uc010tld.1	+	1	928	c.928G>T	c.(928-930)GCT>TCT	p.A310S		NM_001004479	NP_001004479	Q8NGC9	O11H4_HUMAN	olfactory receptor, family 11, subfamily H,	310	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1	all_cancers(95;0.000888)		Epithelial(56;1.75e-06)|all cancers(55;1.22e-05)	GBM - Glioblastoma multiforme(265;0.0146)		CATGAAACTCGCTCTGAGAAA	0.393													21	142	---	---	---	---	PASS
DHRS4L1	728635	broad.mit.edu	37	14	24505724	24505724	+	Silent	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr14:24505724G>A	uc010alc.2	+	1	15	c.15G>A	c.(13-15)CGG>CGA	p.R5R	DHRS4L1_uc010tnu.1_RNA	NM_001082488	NP_001075957	P0CG22	DR4L1_HUMAN	dehydrogenase/reductase (SDR family) member 4	5							binding|oxidoreductase activity				0						ACAAGGCGCGGCTACGAGGCC	0.662													15	14	---	---	---	---	PASS
HSPA2	3306	broad.mit.edu	37	14	65008628	65008628	+	Missense_Mutation	SNP	A	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr14:65008628A>T	uc001xhj.2	+	2	1137	c.1061A>T	c.(1060-1062)CAG>CTG	p.Q354L	HSPA2_uc001xhk.3_Missense_Mutation_p.Q354L	NM_021979	NP_068814	P54652	HSP72_HUMAN	heat shock 70kDa protein 2	354					response to unfolded protein|spermatid development	cell surface	ATP binding|unfolded protein binding			skin(1)	1				all cancers(60;0.00515)|OV - Ovarian serous cystadenocarcinoma(108;0.00584)|BRCA - Breast invasive adenocarcinoma(234;0.045)		AAGCTGCTGCAGGATTTCTTC	0.627													32	38	---	---	---	---	PASS
LTBP2	4053	broad.mit.edu	37	14	74975970	74975970	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr14:74975970C>T	uc001xqa.2	-	22	3761	c.3374G>A	c.(3373-3375)CGG>CAG	p.R1125Q		NM_000428	NP_000419	Q14767	LTBP2_HUMAN	latent transforming growth factor beta binding	1125	EGF-like 10; calcium-binding (Potential).|Cys-rich.				protein secretion|protein targeting|transforming growth factor beta receptor signaling pathway	extracellular space|proteinaceous extracellular matrix	calcium ion binding|growth factor binding			liver(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(234;0.00219)|READ - Rectum adenocarcinoma(1;0.0649)		GGGGCTGGGCCGGTAGCCCCC	0.627													21	107	---	---	---	---	PASS
TTLL5	23093	broad.mit.edu	37	14	76186151	76186151	+	Missense_Mutation	SNP	G	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr14:76186151G>C	uc001xrx.2	+	11	1121	c.916G>C	c.(916-918)GAA>CAA	p.E306Q	TTLL5_uc010ask.1_Missense_Mutation_p.E306Q|TTLL5_uc001xry.1_Intron	NM_015072	NP_055887	Q6EMB2	TTLL5_HUMAN	tubulin tyrosine ligase-like family, member 5	306	TTL.				protein modification process|transcription, DNA-dependent	centrosome|cilium|microtubule basal body|nucleus	tubulin-tyrosine ligase activity			ovary(2)|central_nervous_system(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.029)		CCTGAAACAAGAAGGCAGAGA	0.393													47	36	---	---	---	---	PASS
TMED8	283578	broad.mit.edu	37	14	77808245	77808245	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr14:77808245C>A	uc001xto.1	-	6	847	c.847G>T	c.(847-849)GAC>TAC	p.D283Y	TMED8_uc010ast.1_RNA|TMED8_uc001xtn.1_Missense_Mutation_p.D127Y	NM_213601	NP_998766	Q6PL24	TMED8_HUMAN	transmembrane emp24 protein transport domain	283	GOLD.				transport	integral to membrane					0			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0281)		CGGTGGCTGTCCCGCCGGTAC	0.607													14	11	---	---	---	---	PASS
ZNF839	55778	broad.mit.edu	37	14	102792675	102792675	+	Silent	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr14:102792675G>A	uc001ylo.2	+	2	644	c.294G>A	c.(292-294)CCG>CCA	p.P98P	ZNF839_uc010awk.1_Silent_p.P214P|ZNF839_uc001ylp.2_RNA|ZNF839_uc001ylq.1_Silent_p.P98P|ZNF839_uc001ylr.2_Silent_p.P98P	NM_018335	NP_060805	A8K0R7	ZN839_HUMAN	zinc finger protein 839	98						intracellular	zinc ion binding			ovary(1)|central_nervous_system(1)	2						CCTCTGACCCGCTGGCAGTAA	0.483													10	9	---	---	---	---	PASS
ADSSL1	122622	broad.mit.edu	37	14	105209529	105209529	+	Splice_Site	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr14:105209529G>T	uc001ypd.2	+	10	1147	c.1073_splice	c.e10+1	p.A358_splice	INF2_uc010tyi.1_Intron|ADSSL1_uc001ype.2_Splice_Site_p.A401_splice|ADSSL1_uc001ypf.2_Splice_Site	NM_152328	NP_689541	Q8N142	PURA1_HUMAN	adenylosuccinate synthase like 1 isoform 2						AMP biosynthetic process|immune system process|purine base metabolic process	cytosol	adenylosuccinate synthase activity|GTP binding|magnesium ion binding|phosphate binding			ovary(1)|central_nervous_system(1)	2		all_cancers(154;0.0896)|Melanoma(154;0.155)|all_epithelial(191;0.172)	all cancers(16;0.00153)|OV - Ovarian serous cystadenocarcinoma(23;0.0148)|Epithelial(46;0.0396)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.18)	L-Aspartic Acid(DB00128)	GATTCACTGCGTAAGCAACCC	0.612													68	55	---	---	---	---	PASS
OR4M2	390538	broad.mit.edu	37	15	22369420	22369420	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr15:22369420C>A	uc010tzu.1	+	1	845	c.845C>A	c.(844-846)CCT>CAT	p.P282H	LOC727924_uc001yua.2_Intron|LOC727924_uc001yub.1_Intron|OR4N4_uc001yuc.1_Intron	NM_001004719	NP_001004719	Q8NGB6	OR4M2_HUMAN	olfactory receptor, family 4, subfamily M,	282	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		TTAATATTCCCTTTACGTAAT	0.383													43	98	---	---	---	---	PASS
HERC2	8924	broad.mit.edu	37	15	28483881	28483881	+	Silent	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr15:28483881C>T	uc001zbj.2	-	24	3721	c.3615G>A	c.(3613-3615)GAG>GAA	p.E1205E		NM_004667	NP_004658	O95714	HERC2_HUMAN	hect domain and RLD 2	1205					DNA repair|intracellular protein transport|protein ubiquitination involved in ubiquitin-dependent protein catabolic process	nucleus	guanyl-nucleotide exchange factor activity|heme binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(4)|lung(4)|skin(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	13		all_lung(180;1.3e-11)|Breast(32;0.000194)|Colorectal(260;0.227)		all cancers(64;3.93e-09)|Epithelial(43;9.99e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0271)|GBM - Glioblastoma multiforme(186;0.0497)|Lung(196;0.199)		GTGTCACTTCCTCATTATTTC	0.368													4	116	---	---	---	---	PASS
RYR3	6263	broad.mit.edu	37	15	33938728	33938728	+	Splice_Site	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr15:33938728G>A	uc001zhi.2	+	29	4011	c.3941_splice	c.e29+1	p.R1314_splice	RYR3_uc010bar.2_Splice_Site_p.R1314_splice	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3						cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TCCAGAAAAGGTGAGGGTGAG	0.517													35	117	---	---	---	---	PASS
C15orf55	256646	broad.mit.edu	37	15	34640787	34640787	+	Missense_Mutation	SNP	G	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr15:34640787G>C	uc001zif.2	+	2	789	c.634G>C	c.(634-636)GAG>CAG	p.E212Q	C15orf55_uc010ucc.1_Missense_Mutation_p.E240Q|C15orf55_uc010ucd.1_Missense_Mutation_p.E230Q	NM_175741	NP_786883	Q86Y26	NUT_HUMAN	nuclear protein in testis	212						cytoplasm|nucleus			BRD4_ENST00000263377/C15orf55(24)|BRD3/C15orf55(3)	midline_organs(25)|ovary(2)|lung(2)|skin(1)	30		all_lung(180;2.78e-08)		all cancers(64;4.53e-18)|GBM - Glioblastoma multiforme(113;8.29e-08)|BRCA - Breast invasive adenocarcinoma(123;0.0249)		GGACGTTTATGAGAACTTCCG	0.542			T	BRD3|BRD4	lethal midline carcinoma								61	75	---	---	---	---	PASS
ITPKA	3706	broad.mit.edu	37	15	41793728	41793728	+	Missense_Mutation	SNP	A	T	T	rs143540732		TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr15:41793728A>T	uc001znz.2	+	2	568	c.557A>T	c.(556-558)TAC>TTC	p.Y186F		NM_002220	NP_002211	P23677	IP3KA_HUMAN	1D-myo-inositol-trisphosphate 3-kinase A	186					signal transduction		ATP binding|calmodulin binding|inositol trisphosphate 3-kinase activity				0		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;7.63e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		AAGAAGCGCTACGCCTGGGTG	0.637													5	27	---	---	---	---	PASS
ATP8B4	79895	broad.mit.edu	37	15	50154566	50154566	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr15:50154566G>A	uc001zxu.2	-	27	3315	c.3173C>T	c.(3172-3174)GCA>GTA	p.A1058V	ATP8B4_uc010ber.2_Missense_Mutation_p.A931V|ATP8B4_uc010ufd.1_Missense_Mutation_p.A868V|ATP8B4_uc010ufe.1_RNA|ATP8B4_uc001zxt.2_Missense_Mutation_p.A61V	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	1058	Extracellular (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		GGAATGTCGTGCATTACCTAT	0.358													31	94	---	---	---	---	PASS
ATP8B4	79895	broad.mit.edu	37	15	50158629	50158629	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr15:50158629C>A	uc001zxu.2	-	26	3222	c.3080G>T	c.(3079-3081)GGG>GTG	p.G1027V	ATP8B4_uc010ber.2_Missense_Mutation_p.G900V|ATP8B4_uc010ufd.1_Missense_Mutation_p.G837V|ATP8B4_uc010ufe.1_RNA|ATP8B4_uc001zxt.2_Missense_Mutation_p.G30V	NM_024837	NP_079113	Q8TF62	AT8B4_HUMAN	ATPase class I type 8B member 4	1027	Helical; (Potential).				ATP biosynthetic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			skin(3)|ovary(2)|breast(2)|large_intestine(1)	8		all_lung(180;0.00183)		all cancers(107;2.41e-07)|GBM - Glioblastoma multiforme(94;8.28e-05)		GGCAATGCTCCCCCAGATGAA	0.383													37	61	---	---	---	---	PASS
UACA	55075	broad.mit.edu	37	15	70968849	70968849	+	Missense_Mutation	SNP	T	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr15:70968849T>C	uc002asr.2	-	13	1218	c.1114A>G	c.(1114-1116)AGA>GGA	p.R372G	UACA_uc010uke.1_Missense_Mutation_p.R263G|UACA_uc002asq.2_Missense_Mutation_p.R359G|UACA_uc010bin.1_Missense_Mutation_p.R347G	NM_018003	NP_060473	Q9BZF9	UACA_HUMAN	uveal autoantigen with coiled-coil domains and	372	Potential.					cytoskeleton|extracellular region				ovary(2)|pancreas(1)|skin(1)	4						TATTTAAATCTATTTTTCAGA	0.229													51	59	---	---	---	---	PASS
CD276	80381	broad.mit.edu	37	15	73996604	73996604	+	Missense_Mutation	SNP	G	A	A	rs150186392	byFrequency	TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr15:73996604G>A	uc002avv.1	+	6	1394	c.1160G>A	c.(1159-1161)CGG>CAG	p.R387Q	CD276_uc010bjd.1_Missense_Mutation_p.R241Q|CD276_uc002avu.1_Missense_Mutation_p.R387Q|CD276_uc002avw.1_Missense_Mutation_p.R169Q|CD276_uc010ulb.1_Missense_Mutation_p.R333Q|CD276_uc002avx.2_RNA	NM_001024736	NP_001019907	Q5ZPR3	CD276_HUMAN	CD276 antigen isoform a	387	Extracellular (Potential).|Ig-like C2-type 2.			R -> Q (in Ref. 3; AAQ88709).	cell proliferation|immune response|positive regulation of interferon-gamma biosynthetic process|positive regulation of T cell proliferation|regulation of immune response|T cell activation	external side of plasma membrane|integral to membrane	receptor binding			skin(1)	1						TCCAGCTACCGGGGCTACCCT	0.637													6	70	---	---	---	---	PASS
ST8SIA2	8128	broad.mit.edu	37	15	92981642	92981642	+	Missense_Mutation	SNP	T	G	G			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr15:92981642T>G	uc002bra.2	+	4	505	c.350T>G	c.(349-351)CTG>CGG	p.L117R	ST8SIA2_uc002brb.2_Missense_Mutation_p.L96R	NM_006011	NP_006002	Q92186	SIA8B_HUMAN	ST8 alpha-N-acetyl-neuraminide	117	Lumenal (Potential).				axon guidance|N-glycan processing|oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to Golgi membrane	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity				0	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0355)|OV - Ovarian serous cystadenocarcinoma(32;0.203)			AAGGGAACCCTGAAGCCTGGA	0.468													104	229	---	---	---	---	PASS
A2BP1	54715	broad.mit.edu	37	16	7568163	7568163	+	Silent	SNP	A	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr16:7568163A>C	uc002cys.2	+	5	1030	c.42A>C	c.(40-42)GCA>GCC	p.A14A	A2BP1_uc010buf.1_Silent_p.A14A|A2BP1_uc002cyr.1_Silent_p.A14A|A2BP1_uc002cyt.2_Silent_p.A14A|A2BP1_uc010uxz.1_Silent_p.A57A|A2BP1_uc010uya.1_Silent_p.A50A|A2BP1_uc002cyv.1_Silent_p.A14A|A2BP1_uc010uyb.1_Silent_p.A14A|A2BP1_uc002cyw.2_Silent_p.A34A|A2BP1_uc002cyy.2_Silent_p.A34A|A2BP1_uc002cyx.2_Silent_p.A34A|A2BP1_uc010uyc.1_Silent_p.A34A	NM_018723	NP_061193	Q9NWB1	RFOX1_HUMAN	ataxin 2-binding protein 1 isoform 4	14					mRNA processing|RNA splicing|RNA transport	nucleus|trans-Golgi network	nucleotide binding|protein C-terminus binding|RNA binding				0		all_cancers(2;4.54e-52)|Colorectal(2;6.95e-44)|all_epithelial(2;1.15e-37)|Lung NSC(2;0.000289)|all_lung(2;0.00148)|Myeloproliferative disorder(2;0.0122)|Medulloblastoma(2;0.0354)|all_neural(2;0.0381)|all_hematologic(2;0.0749)|Renal(2;0.0758)|Melanoma(2;0.211)		Colorectal(1;3.55e-51)|COAD - Colon adenocarcinoma(2;1.92e-46)|all cancers(1;5.36e-16)|Epithelial(1;3.98e-15)|READ - Rectum adenocarcinoma(2;3.71e-05)|GBM - Glioblastoma multiforme(1;0.0499)		ATCAGGAAGCAGCCGCTGCCC	0.582													38	110	---	---	---	---	PASS
TRIM72	493829	broad.mit.edu	37	16	31226446	31226446	+	Silent	SNP	C	G	G			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr16:31226446C>G	uc002ebn.1	+	2	616	c.387C>G	c.(385-387)CTC>CTG	p.L129L		NM_001008274	NP_001008275	Q6ZMU5	TRI72_HUMAN	tripartite motif-containing 72	129					exocytosis|muscle organ development|muscle system process|plasma membrane repair|protein homooligomerization	cytoplasmic vesicle membrane|sarcolemma	phosphatidylserine binding|zinc ion binding				0						ACGCACGCCTCAAGGTGCGGG	0.692													6	11	---	---	---	---	PASS
ITGAX	3687	broad.mit.edu	37	16	31382999	31382999	+	Missense_Mutation	SNP	G	A	A	rs146647978	byFrequency	TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr16:31382999G>A	uc002ebu.1	+	17	2121	c.2054G>A	c.(2053-2055)CGC>CAC	p.R685H	ITGAX_uc002ebt.2_Missense_Mutation_p.R685H	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	685	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GACCCTGGCCGCCTGAGTCCC	0.607													28	75	---	---	---	---	PASS
ITGAX	3687	broad.mit.edu	37	16	31383005	31383005	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr16:31383005G>T	uc002ebu.1	+	17	2127	c.2060G>T	c.(2059-2061)AGT>ATT	p.S687I	ITGAX_uc002ebt.2_Missense_Mutation_p.S687I	NM_000887	NP_000878	P20702	ITAX_HUMAN	integrin alpha X precursor	687	Extracellular (Potential).				blood coagulation|cell adhesion|integrin-mediated signaling pathway|leukocyte migration|organ morphogenesis	integrin complex	protein binding|receptor activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GGCCGCCTGAGTCCCCGTGCC	0.617													17	82	---	---	---	---	PASS
ITGAD	3681	broad.mit.edu	37	16	31424157	31424157	+	Splice_Site	SNP	A	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr16:31424157A>T	uc002ebv.1	+	15	1757	c.1708_splice	c.e15-2	p.R570_splice	ITGAD_uc010cap.1_Splice_Site_p.R571_splice	NM_005353	NP_005344	Q13349	ITAD_HUMAN	integrin, alpha D precursor						cell-cell adhesion|cell-matrix adhesion|immune response|integrin-mediated signaling pathway	integrin complex	receptor activity			skin(1)	1						TCTTCTGGCCAGCGGATTGCC	0.567													44	82	---	---	---	---	PASS
PHKB	5257	broad.mit.edu	37	16	47581411	47581411	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr16:47581411G>T	uc002eev.3	+	7	714	c.662G>T	c.(661-663)TGG>TTG	p.W221L	PHKB_uc010vgi.1_Missense_Mutation_p.W214L|PHKB_uc002eeu.3_Missense_Mutation_p.W214L	NM_000293	NP_000284	Q93100	KPBB_HUMAN	phosphorylase kinase, beta isoform a	221					glucose metabolic process|glycogen catabolic process	cytosol|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity			ovary(1)|large_intestine(1)|breast(1)	3		all_cancers(37;0.00447)|all_lung(18;0.00616)|Lung NSC(13;0.0418)|Breast(268;0.203)				TTTGGTGTCTGGGAAAGAGGA	0.333													29	85	---	---	---	---	PASS
RBL2	5934	broad.mit.edu	37	16	53487406	53487406	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr16:53487406C>T	uc002ehi.3	+	6	927	c.809C>T	c.(808-810)TCT>TTT	p.S270F	RBL2_uc010vgv.1_Missense_Mutation_p.S196F|RBL2_uc002ehj.2_5'UTR|RBL2_uc010vgw.1_Missense_Mutation_p.S54F	NM_005611	NP_005602	Q08999	RBL2_HUMAN	retinoblastoma-like 2 (p130)	270					cell cycle|chromatin modification|regulation of cell cycle|regulation of lipid kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding			ovary(2)|lung(2)|upper_aerodigestive_tract(1)	5						AAACCTTCCTCTGACCCCCCT	0.378													6	319	---	---	---	---	PASS
CLEC3A	10143	broad.mit.edu	37	16	78064472	78064472	+	Missense_Mutation	SNP	G	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr16:78064472G>C	uc002ffh.3	+	3	409	c.328G>C	c.(328-330)GAA>CAA	p.E110Q		NM_005752	NP_005743	O75596	CLC3A_HUMAN	C-type lectin domain family 3 member A	110	C-type lectin.				skeletal system development	extracellular region	sugar binding				0						GAACTCCGACGAAATCAACGC	0.478													24	81	---	---	---	---	PASS
INPP5K	51763	broad.mit.edu	37	17	1399417	1399417	+	Silent	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr17:1399417C>T	uc002fsr.2	-	11	1616	c.1227G>A	c.(1225-1227)GAG>GAA	p.E409E	INPP5K_uc002fss.2_Silent_p.E333E|INPP5K_uc002fsq.2_Silent_p.E333E|INPP5K_uc010cjr.2_Silent_p.E333E|INPP5K_uc010vql.1_Silent_p.E317E|INPP5K_uc010vqm.1_Silent_p.E313E	NM_016532	NP_057616	Q9BT40	INP5K_HUMAN	inositol polyphosphate-5-phosphatase K isoform	409	Required for ruffle localization.				actin cytoskeleton organization	cytosol|endoplasmic reticulum|membrane fraction|neuron projection|ruffle	inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity|inositol bisphosphate phosphatase activity|inositol bisphosphate phosphatase activity|inositol trisphosphate phosphatase activity|inositol-1,4,5-trisphosphate 5-phosphatase activity|inositol-polyphosphate 5-phosphatase activity|lipid phosphatase activity|protein binding				0						AGAGGAGAAACTCATCTTCAG	0.308													51	27	---	---	---	---	PASS
OR3A2	4995	broad.mit.edu	37	17	3181346	3181346	+	Missense_Mutation	SNP	T	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr17:3181346T>A	uc002fvg.2	-	1	923	c.884A>T	c.(883-885)AAC>ATC	p.N295I		NM_002551	NP_002542	P47893	OR3A2_HUMAN	olfactory receptor, family 3, subfamily A,	295	Helical; Name=7; (Potential).				sensory perception of smell	integral to plasma membrane	olfactory receptor activity			ovary(1)	1						GATAAGAGGGTTCAGCATAGG	0.478													69	28	---	---	---	---	PASS
TP53	7157	broad.mit.edu	37	17	7578395	7578395	+	Missense_Mutation	SNP	G	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr17:7578395G>C	uc002gim.2	-	5	729	c.535C>G	c.(535-537)CAT>GAT	p.H179D	TP53_uc002gig.1_Missense_Mutation_p.H179D|TP53_uc002gih.2_Missense_Mutation_p.H179D|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.H47D|TP53_uc010cng.1_Missense_Mutation_p.H47D|TP53_uc002gii.1_Missense_Mutation_p.H47D|TP53_uc010cnh.1_Missense_Mutation_p.H179D|TP53_uc010cni.1_Missense_Mutation_p.H179D|TP53_uc002gij.2_Missense_Mutation_p.H179D|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.H86D|TP53_uc002gio.2_Missense_Mutation_p.H47D|TP53_uc010vug.1_Missense_Mutation_p.H140D	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	179	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	H -> Q (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> R (in sporadic cancers; somatic mutation).|HH -> QS (in a sporadic cancer; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> D (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> Y (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H179R(99)|p.H179Y(74)|p.H179L(31)|p.H179Q(17)|p.H179N(13)|p.H179D(10)|p.P177_C182delPHHERC(8)|p.0?(7)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.H179P(3)|p.R175_E180delRCPHHE(3)|p.H179fs*68(2)|p.H179H(2)|p.P177fs*3(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.K164_P219del(1)|p.C176fs*65(1)|p.C176fs*68(1)|p.P177_H179delPHH(1)|p.V173fs*23(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.E171fs*1(1)|p.H179del(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.H178fs*6(1)|p.P177_E180delPHHE(1)|p.R42fs*24(1)|p.R174fs*3(1)|p.H178_H179>QY(1)|p.E171fs*61(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		CAGCGCTCATGGTGGGGGCAG	0.642		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			51	24	---	---	---	---	PASS
MYH4	4622	broad.mit.edu	37	17	10358039	10358039	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr17:10358039G>T	uc002gmn.2	-	22	2635	c.2524C>A	c.(2524-2526)CCC>ACC	p.P842T	uc002gml.1_Intron	NM_017533	NP_060003	Q9Y623	MYH4_HUMAN	myosin, heavy polypeptide 4, skeletal muscle	842					muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(10)|skin(2)|central_nervous_system(1)	13						TTGAGGAGGGGCTTGATCTTG	0.453													47	34	---	---	---	---	PASS
DNAH9	1770	broad.mit.edu	37	17	11797796	11797796	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr17:11797796G>A	uc002gne.2	+	59	11457	c.11389G>A	c.(11389-11391)GCG>ACG	p.A3797T	DNAH9_uc010coo.2_Missense_Mutation_p.A3091T|DNAH9_uc002gnf.2_Missense_Mutation_p.A109T|DNAH9_uc010vvh.1_Missense_Mutation_p.A150T	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	3797					cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CTCCCATCAGGCGTGGGGAGC	0.547													42	33	---	---	---	---	PASS
BRCA1	672	broad.mit.edu	37	17	41245215	41245215	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr17:41245215C>T	uc002icq.2	-	10	2565	c.2333G>A	c.(2332-2334)GGC>GAC	p.G778D	BRCA1_uc010whp.1_Intron|BRCA1_uc010whl.1_Intron|BRCA1_uc010whm.1_Intron|BRCA1_uc002icp.3_Missense_Mutation_p.G707D|BRCA1_uc002icu.2_Intron|BRCA1_uc010cyx.2_Missense_Mutation_p.G731D|BRCA1_uc002ict.2_Missense_Mutation_p.G778D|BRCA1_uc010whn.1_Intron|BRCA1_uc010who.1_Intron|BRCA1_uc010whq.1_Intron|BRCA1_uc002idc.1_Intron|BRCA1_uc010whr.1_Intron|BRCA1_uc002idd.2_Missense_Mutation_p.G778D|BRCA1_uc002ide.1_Missense_Mutation_p.G609D|BRCA1_uc010cyy.1_Missense_Mutation_p.G778D|BRCA1_uc010whs.1_Missense_Mutation_p.G778D|BRCA1_uc010cyz.2_Missense_Mutation_p.G731D|BRCA1_uc010cza.2_Missense_Mutation_p.G752D|BRCA1_uc010wht.1_Missense_Mutation_p.G482D	NM_007294	NP_009225	P38398	BRCA1_HUMAN	breast cancer 1, early onset isoform 1	778			G -> C (in a breast cancer sample; somatic mutation).		androgen receptor signaling pathway|apoptosis|cellular response to indole-3-methanol|chromosome segregation|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|DNA damage response, signal transduction resulting in induction of apoptosis|double-strand break repair via homologous recombination|fatty acid biosynthetic process|G2/M transition DNA damage checkpoint|negative regulation of centriole replication|negative regulation of fatty acid biosynthetic process|negative regulation of histone H3-K9 methylation|negative regulation of transcription, DNA-dependent|positive regulation of cell cycle arrest|positive regulation of DNA repair|positive regulation of histone acetylation|positive regulation of histone H3-K4 methylation|positive regulation of histone H4-K20 methylation|positive regulation of protein ubiquitination|positive regulation of transcription from RNA polymerase II promoter|postreplication repair|protein autoubiquitination|protein K6-linked ubiquitination|regulation of cell motility|regulation of cell proliferation|regulation of transcription from RNA polymerase III promoter|response to estrogen stimulus|response to ionizing radiation|substrate adhesion-dependent cell spreading	BRCA1-A complex|BRCA1-BARD1 complex|gamma-tubulin ring complex|nucleoplasm|plasma membrane|ribonucleoprotein complex|ruffle	androgen receptor binding|identical protein binding|protein binding|RNA binding|transcription coactivator activity|transcription regulatory region DNA binding|tubulin binding|ubiquitin protein ligase binding|ubiquitin-protein ligase activity|zinc ion binding	p.G778C(1)		ovary(24)|breast(21)|lung(4)|central_nervous_system(1)|endometrium(1)|urinary_tract(1)	52		Breast(137;0.000717)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TTCCTGAGTGCCATAATCAGT	0.418			D|Mis|N|F|S		ovarian	breast|ovarian		Homologous_recombination	Hereditary_Breast-Ovarian_Cancer_BRCA1_type	TCGA Ovarian(2;0.000030)			152	221	---	---	---	---	PASS
GRN	2896	broad.mit.edu	37	17	42429094	42429094	+	Silent	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr17:42429094C>T	uc002igp.1	+	10	1329	c.1110C>T	c.(1108-1110)AGC>AGT	p.S370S	GRN_uc002igr.1_Silent_p.S164S	NM_002087	NP_002078	P28799	GRN_HUMAN	granulin precursor	370					signal transduction	extracellular space	cytokine activity|growth factor activity			ovary(2)|central_nervous_system(2)|skin(1)	5		Prostate(33;0.0181)		BRCA - Breast invasive adenocarcinoma(366;0.189)		ATAATGTCAGCAGCTGTCCCT	0.612													62	70	---	---	---	---	PASS
SCRN2	90507	broad.mit.edu	37	17	45915974	45915974	+	Silent	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr17:45915974G>A	uc002imd.2	-	6	987	c.861C>T	c.(859-861)GCC>GCT	p.A287A	SCRN2_uc002imc.2_Silent_p.A295A|SCRN2_uc002imf.2_Silent_p.A287A|SCRN2_uc002ime.2_RNA	NM_138355	NP_612364	Q96FV2	SCRN2_HUMAN	secernin 2 isoform 1	287					proteolysis		dipeptidase activity			ovary(1)	1						ACACCATGCTGGCCGTGGTGC	0.607													46	74	---	---	---	---	PASS
CBX8	57332	broad.mit.edu	37	17	77768640	77768640	+	Missense_Mutation	SNP	G	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr17:77768640G>C	uc002jxd.1	-	5	1057	c.964C>G	c.(964-966)CGG>GGG	p.R322G		NM_020649	NP_065700	Q9HC52	CBX8_HUMAN	chromobox homolog 8	322					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear chromatin|PcG protein complex	methylated histone residue binding				0			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			CCCATGTCCCGGTACAGGCCC	0.701													9	28	---	---	---	---	PASS
CCDC40	55036	broad.mit.edu	37	17	78071154	78071154	+	Silent	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr17:78071154C>T	uc010dht.2	+	19	3159	c.3132C>T	c.(3130-3132)TTC>TTT	p.F1044F	CCDC40_uc002jxm.3_Silent_p.F827F|CCDC40_uc002jxn.3_Silent_p.F440F	NM_017950	NP_060420	Q4G0X9	CCD40_HUMAN	coiled-coil domain containing 40	1044	Potential.				axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium|cytoplasm				ovary(3)	3	all_neural(118;0.167)		OV - Ovarian serous cystadenocarcinoma(97;0.0292)|BRCA - Breast invasive adenocarcinoma(99;0.149)			AGGCAGACTTCGACACACTCG	0.562													12	107	---	---	---	---	PASS
DSC1	1823	broad.mit.edu	37	18	28712547	28712547	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr18:28712547G>T	uc002kwn.2	-	14	2484	c.2222C>A	c.(2221-2223)CCT>CAT	p.P741H	DSC1_uc002kwm.2_Missense_Mutation_p.P741H	NM_024421	NP_077739	Q08554	DSC1_HUMAN	desmocollin 1 isoform Dsc1a preproprotein	741	Cytoplasmic (Potential).				homophilic cell adhesion	desmosome|gap junction|integral to membrane|membrane fraction	calcium ion binding			ovary(3)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(10;0.00778)			TTCTTCTCCAGGTCCTTCAGT	0.343													69	158	---	---	---	---	PASS
KIAA1632	57724	broad.mit.edu	37	18	43458381	43458381	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr18:43458381G>T	uc002lbm.2	-	34	6002	c.5902C>A	c.(5902-5904)CTC>ATC	p.L1968I	KIAA1632_uc010xcq.1_Missense_Mutation_p.L522I|KIAA1632_uc010xcr.1_RNA|KIAA1632_uc010xcs.1_RNA|KIAA1632_uc002lbn.2_Missense_Mutation_p.L843I	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	1968					autophagy						0						GGCTTAAAGAGCTGAATGATT	0.323													35	82	---	---	---	---	PASS
HMHA1	23526	broad.mit.edu	37	19	1068656	1068656	+	Missense_Mutation	SNP	G	T	T	rs138476769		TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr19:1068656G>T	uc002lqz.1	+	2	565	c.334G>T	c.(334-336)GTC>TTC	p.V112F	HMHA1_uc010xgd.1_Missense_Mutation_p.V128F|HMHA1_uc010xge.1_Intron|HMHA1_uc002lra.1_5'UTR|HMHA1_uc002lrb.1_5'Flank	NM_012292	NP_036424	Q92619	HMHA1_HUMAN	minor histocompatibility antigen HA-1	112					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding			lung(1)	1		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGGCCCGGACGTCGTCGAGGA	0.692													11	40	---	---	---	---	PASS
FUT5	2527	broad.mit.edu	37	19	5867472	5867472	+	Missense_Mutation	SNP	C	G	G	rs141356302		TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr19:5867472C>G	uc002mdo.3	-	2	353	c.265G>C	c.(265-267)GTG>CTG	p.V89L	FUT5_uc010duo.2_Missense_Mutation_p.V89L	NM_002034	NP_002025	Q11128	FUT5_HUMAN	fucosyltransferase 5	89	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity|alpha(1,3)-fucosyltransferase activity				0						GGCAGAGCCACGGGTGTGTTA	0.662													18	43	---	---	---	---	PASS
EMR1	2015	broad.mit.edu	37	19	6901981	6901981	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr19:6901981G>A	uc002mfw.2	+	6	648	c.610G>A	c.(610-612)GAA>AAA	p.E204K	EMR1_uc010dvc.2_Missense_Mutation_p.E204K|EMR1_uc010dvb.2_Missense_Mutation_p.E152K|EMR1_uc010xji.1_Intron|EMR1_uc010xjj.1_Intron	NM_001974	NP_001965	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone	204	Extracellular (Potential).|EGF-like 4; calcium-binding (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	all_hematologic(4;0.166)					CCCAGGATTTGAATCCAGCAG	0.473													107	195	---	---	---	---	PASS
EVI5L	115704	broad.mit.edu	37	19	7914140	7914140	+	Splice_Site	SNP	A	G	G			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr19:7914140A>G	uc002min.2	+	5	707	c.553_splice	c.e5-2	p.A185_splice	EVI5L_uc010xjz.1_Splice_Site_p.A185_splice|EVI5L_uc002mio.1_5'Flank	NM_145245	NP_660288	Q96CN4	EVI5L_HUMAN	ecotropic viral integration site 5-like isoform							intracellular	protein binding|Rab GTPase activator activity			ovary(1)	1						GTTCCCTTCTAGGCATACTCG	0.652													25	54	---	---	---	---	PASS
OR2Z1	284383	broad.mit.edu	37	19	8842253	8842253	+	Missense_Mutation	SNP	T	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr19:8842253T>C	uc010xkg.1	+	1	863	c.863T>C	c.(862-864)CTT>CCT	p.L288P		NM_001004699	NP_001004699	Q8NG97	OR2Z1_HUMAN	olfactory receptor, family 2, subfamily Z,	288	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)|skin(1)	2						CTCAACCCCCTTATCTACAGT	0.517													38	58	---	---	---	---	PASS
ZNF266	10781	broad.mit.edu	37	19	9524910	9524910	+	Missense_Mutation	SNP	T	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr19:9524910T>C	uc002mll.2	-	4	957	c.691A>G	c.(691-693)ATG>GTG	p.M231V	ZNF266_uc002mlm.2_Missense_Mutation_p.M231V|ZNF266_uc002mln.2_Missense_Mutation_p.M231V|ZNF266_uc002mlo.2_Missense_Mutation_p.M231V|ZNF266_uc010dwp.2_Missense_Mutation_p.M231V|ZNF266_uc010dwq.2_Missense_Mutation_p.M231V	NM_198058	NP_932175	Q14584	ZN266_HUMAN	zinc finger protein 266	231	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						TGGGTTCCCATGTGAATATTA	0.428													32	56	---	---	---	---	PASS
SMARCA4	6597	broad.mit.edu	37	19	11096052	11096052	+	Missense_Mutation	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr19:11096052C>T	uc002mqf.3	+	3	610	c.326C>T	c.(325-327)CCG>CTG	p.P109L	SMARCA4_uc010dxp.2_Missense_Mutation_p.P109L|SMARCA4_uc010dxo.2_Missense_Mutation_p.P109L|SMARCA4_uc002mqg.1_Missense_Mutation_p.P109L|SMARCA4_uc010dxq.2_Missense_Mutation_p.P109L|SMARCA4_uc010dxr.2_Missense_Mutation_p.P109L|SMARCA4_uc002mqj.3_Missense_Mutation_p.P109L|SMARCA4_uc010dxs.2_Missense_Mutation_p.P109L|SMARCA4_uc002mqe.2_Missense_Mutation_p.P109L	NM_003072	NP_003063	P51532	SMCA4_HUMAN	SWI/SNF-related matrix-associated	109	Necessary for interaction with SS18L1/CREST (By similarity).				chromatin remodeling|negative regulation of androgen receptor signaling pathway|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|nervous system development|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nuclear chromatin|SWI/SNF complex|WINAC complex	androgen receptor binding|ATP binding|DNA binding|DNA-dependent ATPase activity|helicase activity|histone acetyl-lysine binding|identical protein binding|p53 binding|protein N-terminus binding|transcription corepressor activity	p.?(1)		lung(29)|ovary(8)|pancreas(7)|large_intestine(5)|central_nervous_system(5)|skin(3)|prostate(3)|breast(2)|adrenal_gland(1)|stomach(1)|liver(1)|autonomic_ganglia(1)|kidney(1)	67		all_lung(6;0.0512)|Lung NSC(9;0.0568)				ATGGGGCCCCCGCCCAGCCCC	0.587			F|N|Mis		NSCLC				Rhabdoid_Predisposition_syndrome				4	35	---	---	---	---	PASS
CCDC159	126075	broad.mit.edu	37	19	11460627	11460627	+	Silent	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr19:11460627G>A	uc010xlw.1	+	4	397	c.318G>A	c.(316-318)GTG>GTA	p.V106V	CCDC159_uc010xlr.1_Silent_p.V23V|CCDC159_uc010xls.1_Silent_p.V23V|CCDC159_uc010xlt.1_Silent_p.V23V|CCDC159_uc010xlu.1_Silent_p.V22V|CCDC159_uc010xlv.1_Silent_p.V22V	NM_001080503	NP_001073972	P0C7I6	CC159_HUMAN	coiled-coil domain-containing-like	138										ovary(1)	1						AGACCATTGTGATGATTCCCG	0.592													5	41	---	---	---	---	PASS
CCDC151	115948	broad.mit.edu	37	19	11537702	11537702	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr19:11537702C>A	uc002mrs.2	-	4	746	c.603G>T	c.(601-603)GAG>GAT	p.E201D	CCDC151_uc002mrr.2_Missense_Mutation_p.E136D|CCDC151_uc010dxz.2_Missense_Mutation_p.E175D	NM_145045	NP_659482	A5D8V7	CC151_HUMAN	coiled-coil domain containing 151	201	Potential.									ovary(1)	1						CCTTGGCCACCTCCGTGTGTC	0.682													38	69	---	---	---	---	PASS
ZNF91	7644	broad.mit.edu	37	19	23543202	23543202	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr19:23543202C>A	uc002nre.2	-	4	2692	c.2579G>T	c.(2578-2580)GGC>GTC	p.G860V	ZNF91_uc002nrd.2_5'Flank|ZNF91_uc010xrj.1_Missense_Mutation_p.G828V	NM_003430	NP_003421	Q05481	ZNF91_HUMAN	zinc finger protein 91	860	C2H2-type 26.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		all_lung(12;0.0349)|Lung NSC(12;0.0538)|all_epithelial(12;0.0611)				AAAAGCTTTGCCACATTCCTC	0.348													22	56	---	---	---	---	PASS
PSG6	5675	broad.mit.edu	37	19	43414815	43414815	+	Missense_Mutation	SNP	T	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr19:43414815T>C	uc002ovj.1	-	3	675	c.623A>G	c.(622-624)AAG>AGG	p.K208R	PSG3_uc002ouf.2_Intron|PSG11_uc002ouw.2_Intron|PSG7_uc002ous.1_Intron|PSG7_uc002out.1_Intron|PSG10_uc002ouv.1_Intron|PSG6_uc002ovh.1_Missense_Mutation_p.K215R|PSG6_uc002ovi.2_Missense_Mutation_p.K209R|PSG6_uc010xwk.1_Intron|PSG11_uc002ovk.1_Intron|PSG6_uc002ove.1_5'UTR|PSG6_uc002ovf.1_Missense_Mutation_p.K208R|PSG6_uc002ovg.1_Missense_Mutation_p.K208R	NM_002782	NP_002773	Q00889	PSG6_HUMAN	pregnancy specific beta-1-glycoprotein 6 isoform	208	Ig-like C2-type 1.				female pregnancy	extracellular region				ovary(1)|skin(1)	2		Prostate(69;0.00899)				TGCAATATACTTTGTGACACC	0.498													3	280	---	---	---	---	PASS
PSG5	5673	broad.mit.edu	37	19	43680259	43680259	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr19:43680259G>A	uc002ovu.2	-	3	603	c.472C>T	c.(472-474)CCC>TCC	p.P158S	PSG6_uc010xwk.1_Intron|PSG5_uc010eir.2_Intron|PSG5_uc002ovx.2_Missense_Mutation_p.P158S|PSG5_uc002ovv.2_Missense_Mutation_p.P251S|PSG5_uc002ovw.2_Intron	NM_002781	NP_002772	Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	158	Ig-like C2-type 1.				female pregnancy	extracellular region				skin(3)	3		Prostate(69;0.00899)				TTCTCCCTGGGTTTTGAGTTG	0.493													7	336	---	---	---	---	PASS
SULT2A1	6822	broad.mit.edu	37	19	48387031	48387031	+	Missense_Mutation	SNP	A	T	T	rs144058411	byFrequency	TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr19:48387031A>T	uc002phr.2	-	2	288	c.148T>A	c.(148-150)TTG>ATG	p.L50M		NM_003167	NP_003158	Q06520	ST2A1_HUMAN	bile-salt sulfotransferase 2A1	50					3'-phosphoadenosine 5'-phosphosulfate metabolic process|bile acid catabolic process|cellular lipid metabolic process|digestion|sulfation|xenobiotic metabolic process	cytosol	bile-salt sulfotransferase activity			ovary(1)|pancreas(1)	2		all_cancers(25;3.02e-09)|all_lung(116;6.48e-07)|all_epithelial(76;7.35e-07)|Lung NSC(112;1.56e-06)|all_neural(266;0.0146)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;0.000254)|all cancers(93;0.000545)|Epithelial(262;0.0217)|GBM - Glioblastoma multiforme(486;0.0552)		ATCTCAGCCAACCAGTTTGTT	0.358													7	25	---	---	---	---	PASS
KLK7	5650	broad.mit.edu	37	19	51483083	51483083	+	Silent	SNP	C	G	G			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr19:51483083C>G	uc002puo.2	-	5	669	c.567G>C	c.(565-567)CTG>CTC	p.L189L	KLK7_uc002pup.2_Silent_p.L189L|KLK7_uc010yco.1_Silent_p.L63L|KLK7_uc010eok.2_Silent_p.L117L	NM_139277	NP_644806	P49862	KLK7_HUMAN	stratum corneum chymotryptic enzyme	189	Peptidase S1.				epidermis development|proteolysis	extracellular region	serine-type endopeptidase activity				0		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.00382)|GBM - Glioblastoma multiforme(134;0.00895)		TGCCAGCGCACAGCATGGAAT	0.567													6	12	---	---	---	---	PASS
ZNF320	162967	broad.mit.edu	37	19	53383976	53383976	+	Missense_Mutation	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr19:53383976G>T	uc002qag.2	-	4	1594	c.1403C>A	c.(1402-1404)TCT>TAT	p.S468Y	ZNF320_uc010eqh.1_5'Flank|ZNF320_uc010eqi.1_Intron|ZNF320_uc002qah.2_Missense_Mutation_p.S414Y|ZNF320_uc002qai.2_Missense_Mutation_p.S468Y	NM_207333	NP_997216	A2RRD8	ZN320_HUMAN	zinc finger protein 320	468					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				GBM - Glioblastoma multiforme(134;0.0534)		ACATTTGTAAGATTTCTGTCC	0.408													8	73	---	---	---	---	PASS
ZNF677	342926	broad.mit.edu	37	19	53740505	53740505	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr19:53740505C>A	uc002qbf.1	-	5	1660	c.1475G>T	c.(1474-1476)TGT>TTT	p.C492F	ZNF677_uc002qbg.1_Missense_Mutation_p.C492F	NM_182609	NP_872415	Q86XU0	ZN677_HUMAN	zinc finger protein 677	492	C2H2-type 9.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.00352)		GGCTTTGCCACATTCAGTACA	0.363													26	61	---	---	---	---	PASS
CACNG7	59284	broad.mit.edu	37	19	54417765	54417765	+	Missense_Mutation	SNP	G	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr19:54417765G>C	uc002qcr.1	+	2	223	c.208G>C	c.(208-210)GGT>CGT	p.G70R	CACNG7_uc010era.1_Missense_Mutation_p.G70R	NM_031896	NP_114102	P62955	CCG7_HUMAN	voltage-dependent calcium channel gamma-7	70					regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex|voltage-gated calcium channel complex	voltage-gated calcium channel activity			ovary(1)	1	all_cancers(19;0.0462)|all_epithelial(19;0.0258)|all_lung(19;0.185)|Ovarian(34;0.19)|Lung NSC(19;0.218)			GBM - Glioblastoma multiforme(134;0.0711)		TCGGGAGAAAGGTCGCTGTGT	0.552													8	38	---	---	---	---	PASS
NLRP4	147945	broad.mit.edu	37	19	56370090	56370090	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr19:56370090G>A	uc002qmd.3	+	3	1753	c.1331G>A	c.(1330-1332)CGT>CAT	p.R444H	NLRP4_uc002qmf.2_Missense_Mutation_p.R369H|NLRP4_uc010etf.2_Missense_Mutation_p.R275H	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	444	NACHT.						ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		TACGGGGAGCGTGAGAGCTCC	0.532													44	110	---	---	---	---	PASS
ZNF264	9422	broad.mit.edu	37	19	57723617	57723617	+	Silent	SNP	A	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr19:57723617A>T	uc002qob.2	+	4	1565	c.1152A>T	c.(1150-1152)GCA>GCT	p.A384A		NM_003417	NP_003408	O43296	ZN264_HUMAN	zinc finger protein 264	384	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0822)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0135)		TGGAGAGTGCAGCCCTGATTC	0.527													16	40	---	---	---	---	PASS
FAM83D	81610	broad.mit.edu	37	20	37580822	37580822	+	Missense_Mutation	SNP	T	G	G			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr20:37580822T>G	uc002xjg.2	+	4	1548	c.1507T>G	c.(1507-1509)TCC>GCC	p.S503A		NM_030919	NP_112181	Q9H4H8	FA83D_HUMAN	hypothetical protein LOC81610	473	Ser-rich.				cell division|mitosis	cytoplasm|spindle pole				ovary(3)	3		Myeloproliferative disorder(115;0.00878)				ATCGAGATCTTCCAGTTTGAA	0.488													56	62	---	---	---	---	PASS
SEMG2	6407	broad.mit.edu	37	20	43851456	43851456	+	Missense_Mutation	SNP	C	G	G			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr20:43851456C>G	uc010ggz.2	+	2	1240	c.1183C>G	c.(1183-1185)CAA>GAA	p.Q395E	SEMG2_uc002xnk.2_Missense_Mutation_p.Q395E|SEMG2_uc002xnl.2_Intron	NM_003008	NP_002999	Q02383	SEMG2_HUMAN	semenogelin II precursor	395	Repeat-rich region.|4 X 60 AA tandem repeats, type I.				sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(1)	1		Myeloproliferative disorder(115;0.0122)				AATTCCTAGTCAAGCTCAAGA	0.398													6	63	---	---	---	---	PASS
LAMA5	3911	broad.mit.edu	37	20	60901774	60901774	+	Missense_Mutation	SNP	T	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr20:60901774T>C	uc002ycq.2	-	40	5324	c.5257A>G	c.(5257-5259)ACG>GCG	p.T1753A		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	1753	Laminin IV type A.				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGGCCAGGCGTGGGGTATGCC	0.657													33	24	---	---	---	---	PASS
ARFGAP1	55738	broad.mit.edu	37	20	61907461	61907461	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr20:61907461G>A	uc002yem.2	+	3	191	c.79G>A	c.(79-81)GCG>ACG	p.A27T	ARFGAP1_uc011aas.1_Intron|ARFGAP1_uc011aat.1_5'UTR|ARFGAP1_uc002yel.2_Missense_Mutation_p.A27T|ARFGAP1_uc002yen.2_Missense_Mutation_p.A27T	NM_018209	NP_060679	Q8N6T3	ARFG1_HUMAN	ADP-ribosylation factor GTPase activating	27	C4-type.|Arf-GAP.				COPI coating of Golgi vesicle|protein transport|regulation of ARF GTPase activity|retrograde vesicle-mediated transport, Golgi to ER	cytosol|Golgi-associated vesicle membrane	ARF GTPase activator activity|zinc ion binding			pancreas(1)	1	all_cancers(38;1.59e-09)					TGAGTGTGGCGCGTTCAATCC	0.612													10	213	---	---	---	---	PASS
TFF3	7033	broad.mit.edu	37	21	43735446	43735446	+	Silent	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr21:43735446C>T	uc002zav.2	-	1	261	c.189G>A	c.(187-189)CTG>CTA	p.L63L		NM_003226	NP_003217	Q07654	TFF3_HUMAN	trefoil factor 3 precursor	13					defense response|digestion	apical lamina of hyaline layer				skin(1)	1						ACAGCAAGGCCAGGACCAGCC	0.647													30	31	---	---	---	---	PASS
HIRA	7290	broad.mit.edu	37	22	19394780	19394780	+	Missense_Mutation	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr22:19394780G>A	uc002zpf.1	-	4	449	c.229C>T	c.(229-231)CGG>TGG	p.R77W	HIRA_uc011agx.1_5'UTR|HIRA_uc010grn.1_Missense_Mutation_p.R77W|HIRA_uc010gro.1_Missense_Mutation_p.R33W|HIRA_uc010grp.2_RNA	NM_003325	NP_003316	P54198	HIRA_HUMAN	HIR histone cell cycle regulation defective	77	WD 2.				chromatin modification|regulation of transcription from RNA polymerase II promoter	PML body	chromatin binding|protein binding|sequence-specific DNA binding transcription factor activity|transcription corepressor activity			ovary(1)	1	Colorectal(54;0.0993)					TTTGACCACCGCACACAGTTC	0.423													4	125	---	---	---	---	PASS
CCDC116	164592	broad.mit.edu	37	22	21988721	21988721	+	Silent	SNP	T	C	C			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr22:21988721T>C	uc002zve.2	+	3	576	c.483T>C	c.(481-483)CAT>CAC	p.H161H	CCDC116_uc011aih.1_Silent_p.H161H	NM_152612	NP_689825	Q8IYX3	CC116_HUMAN	coiled-coil domain containing 116	161										ovary(1)|skin(1)	2	Colorectal(54;0.105)					CCAACTGCCATAGCAGCCTCA	0.627													46	50	---	---	---	---	PASS
LOC96610	96610	broad.mit.edu	37	22	23063563	23063563	+	RNA	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr22:23063563C>A	uc011aim.1	+	167		c.9762C>A								Parts of antibodies, mostly variable regions.												0						ACACAGCTTCCTTGACCATCA	0.542													29	34	---	---	---	---	PASS
LOC96610	96610	broad.mit.edu	37	22	23237706	23237706	+	RNA	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr22:23237706G>A	uc011aim.1	+	363		c.15109G>A			uc011aiw.1_Silent_p.A159A|uc010gtu.1_RNA|uc002zws.2_Intron					Parts of antibodies, mostly variable regions.												0						CCGTCAAGGCGGGAGTGGAGA	0.592													5	73	---	---	---	---	PASS
ADORA2A	135	broad.mit.edu	37	22	24837046	24837046	+	Silent	SNP	C	G	G			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr22:24837046C>G	uc002zzx.2	+	5	1591	c.828C>G	c.(826-828)CTC>CTG	p.L276L	ADORA2A_uc002zzy.3_Silent_p.L276L|ADORA2A_uc011ajs.1_Silent_p.L137L|ADORA2A_uc010gup.2_Silent_p.L276L|ADORA2A_uc010guq.2_Silent_p.L276L|ADORA2A_uc003aab.2_Silent_p.L276L|ADORA2A_uc003aac.2_Silent_p.L137L|C22orf45_uc003aad.1_Intron	NM_000675	NP_000666	P29274	AA2AR_HUMAN	adenosine A2a receptor	276	Helical; Name=7.				apoptosis|blood coagulation|cAMP biosynthetic process|cellular defense response|inflammatory response|nerve growth factor receptor signaling pathway|phagocytosis|sensory perception	integral to plasma membrane|membrane fraction	enzyme binding				0	Colorectal(2;0.196)				Caffeine(DB00201)|Defibrotide(DB04932)|Pegademase bovine(DB00061)|Theophylline(DB00277)	CCATCGTCCTCTCCCACACCA	0.587													7	103	---	---	---	---	PASS
ADORA2A	135	broad.mit.edu	37	22	24837160	24837160	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr22:24837160C>A	uc002zzx.2	+	5	1705	c.942C>A	c.(940-942)TTC>TTA	p.F314L	ADORA2A_uc002zzy.3_Missense_Mutation_p.F314L|ADORA2A_uc011ajs.1_Missense_Mutation_p.F175L|ADORA2A_uc010gup.2_Missense_Mutation_p.F314L|ADORA2A_uc010guq.2_Missense_Mutation_p.F314L|ADORA2A_uc003aab.2_Missense_Mutation_p.F314L|ADORA2A_uc003aac.2_Missense_Mutation_p.F175L|C22orf45_uc003aad.1_Intron	NM_000675	NP_000666	P29274	AA2AR_HUMAN	adenosine A2a receptor	314	Cytoplasmic.				apoptosis|blood coagulation|cAMP biosynthetic process|cellular defense response|inflammatory response|nerve growth factor receptor signaling pathway|phagocytosis|sensory perception	integral to plasma membrane|membrane fraction	enzyme binding				0	Colorectal(2;0.196)				Caffeine(DB00201)|Defibrotide(DB04932)|Pegademase bovine(DB00061)|Theophylline(DB00277)	AAGAACCTTTCAAGGCAGCTG	0.617													6	72	---	---	---	---	PASS
C22orf36	388886	broad.mit.edu	37	22	24985841	24985841	+	Missense_Mutation	SNP	A	G	G			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr22:24985841A>G	uc003aaq.2	-	2	283	c.254T>C	c.(253-255)ATC>ACC	p.I85T	GGT1_uc003aan.1_Intron|C22orf36_uc003aao.2_5'Flank|C22orf36_uc003aap.2_RNA	NM_207644	NP_997527	Q2VPJ9	LRC6X_HUMAN	hypothetical protein LOC388886	85											0						GTCATGGGAGATGGGGTCGAC	0.562													18	48	---	---	---	---	PASS
ISX	91464	broad.mit.edu	37	22	35463100	35463100	+	Missense_Mutation	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr22:35463100C>A	uc003anj.2	+	1	971	c.20C>A	c.(19-21)CCT>CAT	p.P7H	ISX_uc011amg.1_Translation_Start_Site	NM_001008494	NP_001008494	Q2M1V0	ISX_HUMAN	intestine-specific homeobox	7						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(3)|skin(2)	5						GAGGTGGGCCCTGCTCTCTGC	0.597													28	35	---	---	---	---	PASS
ZC3H7B	23264	broad.mit.edu	37	22	41716691	41716691	+	Silent	SNP	C	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr22:41716691C>T	uc003azw.2	+	2	243	c.27C>T	c.(25-27)GAC>GAT	p.D9D	ZC3H7B_uc003azv.1_Silent_p.D9D|ZC3H7B_uc010gyl.1_Intron	NM_017590	NP_060060	Q9UGR2	Z3H7B_HUMAN	zinc finger CCCH-type containing 7B	9					interspecies interaction between organisms	nucleus	nucleic acid binding|protein binding|zinc ion binding			central_nervous_system(1)	1						GGAAGGCGGACATCGAGAAAG	0.607													26	173	---	---	---	---	PASS
ZBED4	9889	broad.mit.edu	37	22	50278006	50278006	+	Silent	SNP	T	G	G			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr22:50278006T>G	uc003bix.2	+	2	1166	c.696T>G	c.(694-696)TCT>TCG	p.S232S		NM_014838	NP_055653	O75132	ZBED4_HUMAN	zinc finger, BED-type containing 4	232						cytoplasm|nucleus	DNA binding|metal ion binding|protein dimerization activity			ovary(2)	2		all_cancers(38;8.58e-10)|all_epithelial(38;1.15e-08)|all_lung(38;0.000109)|Lung NSC(38;0.0018)|Breast(42;0.00191)|Ovarian(80;0.0164)|Lung SC(80;0.164)		UCEC - Uterine corpus endometrioid carcinoma (28;0.168)|BRCA - Breast invasive adenocarcinoma(115;0.2)|LUAD - Lung adenocarcinoma(64;0.247)		TAGTTTCTTCTGAAGAAATCT	0.527													37	109	---	---	---	---	PASS
RPS6KA6	27330	broad.mit.edu	37	X	83320047	83320047	+	Missense_Mutation	SNP	A	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chrX:83320047A>T	uc004eej.1	-	21	2121	c.2044T>A	c.(2044-2046)TGG>AGG	p.W682R	RPS6KA6_uc011mqt.1_Missense_Mutation_p.W682R|RPS6KA6_uc011mqu.1_Missense_Mutation_p.W579R	NM_014496	NP_055311	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase polypeptide 6	682	Protein kinase 2.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|central_nervous_system(1)|skin(1)	8						TGAGTTATCCATGAGTGCTTT	0.343													32	95	---	---	---	---	PASS
TCEAL2	140597	broad.mit.edu	37	X	101382216	101382216	+	Silent	SNP	C	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chrX:101382216C>A	uc004eip.2	+	3	633	c.414C>A	c.(412-414)GCC>GCA	p.A138A		NM_080390	NP_525129	Q9H3H9	TCAL2_HUMAN	transcription elongation factor A (SII)-like 2	138					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0						CCAGGAAAGCCAAAAGAAAAA	0.358													50	35	---	---	---	---	PASS
NUP62CL	54830	broad.mit.edu	37	X	106410992	106410992	+	Silent	SNP	G	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chrX:106410992G>A	uc004ena.2	-	4	340	c.81C>T	c.(79-81)ACC>ACT	p.T27T	NUP62CL_uc004enb.2_RNA	NM_017681	NP_060151	Q9H1M0	N62CL_HUMAN	nucleoporin 62kDa C-terminal like	27	Thr-rich.				protein transport	nuclear pore	structural constituent of nuclear pore				0						tgaaagtggcggtggtagtcg	0.229													32	105	---	---	---	---	PASS
L1CAM	3897	broad.mit.edu	37	X	153136600	153136600	+	Silent	SNP	G	T	T			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chrX:153136600G>T	uc004fjb.2	-	5	543	c.435C>A	c.(433-435)CCC>CCA	p.P145P	L1CAM_uc004fjc.2_Silent_p.P145P|L1CAM_uc010nuo.2_Silent_p.P140P|L1CAM_uc004fjd.1_5'Flank|L1CAM_uc004fje.1_Silent_p.P140P	NM_000425	NP_000416	P32004	L1CAM_HUMAN	L1 cell adhesion molecule isoform 1 precursor	145	Extracellular (Potential).|Ig-like C2-type 2.				axon guidance|blood coagulation|cell death|leukocyte migration	integral to membrane				ovary(8)|central_nervous_system(1)	9	all_cancers(53;6.72e-15)|all_epithelial(53;3.19e-09)|all_lung(58;3.39e-06)|all_hematologic(71;4.25e-06)|Lung NSC(58;4.7e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					CCACCTCCACGGGCTTCACTG	0.617													39	15	---	---	---	---	PASS
LRRN2	10446	broad.mit.edu	37	1	204588718	204588718	+	Frame_Shift_Del	DEL	G	-	-			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr1:204588718delG	uc001hbe.1	-	3	791	c.403delC	c.(403-405)CACfs	p.H135fs	MDM4_uc001hbd.1_Intron|LRRN2_uc001hbf.1_Frame_Shift_Del_p.H135fs|LRRN2_uc009xbf.1_Frame_Shift_Del_p.H135fs|MDM4_uc001hbc.2_Intron	NM_006338	NP_006329	O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2 precursor	135	LRR 3.|Extracellular (Potential).				cell adhesion	integral to membrane	receptor activity			central_nervous_system(2)	2	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			GCAAAGCTGTGGTCCTCCAGC	0.597													152	116	---	---	---	---	
ZNF804A	91752	broad.mit.edu	37	2	185803334	185803334	+	Frame_Shift_Del	DEL	C	-	-			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr2:185803334delC	uc002uph.2	+	4	3805	c.3211delC	c.(3211-3213)CCAfs	p.P1071fs		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1071						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						TACCTTTCCTCCAGCTGCCCT	0.458													100	48	---	---	---	---	
RFTN1	23180	broad.mit.edu	37	3	16475533	16475534	+	Frame_Shift_Ins	INS	-	A	A			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr3:16475533_16475534insA	uc003cay.2	-	3	438_439	c.156_157insT	c.(154-159)CCTGGGfs	p.P52fs	RFTN1_uc010hes.2_Frame_Shift_Ins_p.P16fs	NM_015150	NP_055965	Q14699	RFTN1_HUMAN	raft-linking protein	52_53						plasma membrane				ovary(3)|central_nervous_system(1)	4						GCTGAGGACCCAGGGAGCTCCG	0.668													21	11	---	---	---	---	
NEIL3	55247	broad.mit.edu	37	4	178272546	178272546	+	Frame_Shift_Del	DEL	T	-	-			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr4:178272546delT	uc003iut.2	+	7	999	c.882delT	c.(880-882)ACTfs	p.T294fs	NEIL3_uc010irs.2_Intron	NM_018248	NP_060718	Q8TAT5	NEIL3_HUMAN	nei endonuclease VIII-like 3	294					base-excision repair|nucleotide-excision repair	nucleus	bubble DNA binding|damaged DNA binding|DNA N-glycosylase activity|DNA-(apurinic or apyrimidinic site) lyase activity|double-stranded DNA binding|single-stranded DNA binding|zinc ion binding			lung(2)|ovary(1)|central_nervous_system(1)	4		Breast(14;6.27e-05)|Melanoma(52;0.00102)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.164)		all cancers(43;1.96e-23)|Epithelial(43;2.52e-20)|OV - Ovarian serous cystadenocarcinoma(60;1.89e-11)|GBM - Glioblastoma multiforme(59;9.49e-05)|Colorectal(24;0.00013)|COAD - Colon adenocarcinoma(29;0.000696)|STAD - Stomach adenocarcinoma(60;0.00308)|LUSC - Lung squamous cell carcinoma(193;0.0398)|READ - Rectum adenocarcinoma(43;0.191)		AGCTACCGACTAGAAATACTA	0.368								BER_DNA_glycosylases					44	51	---	---	---	---	
CNTN5	53942	broad.mit.edu	37	11	99944959	99944959	+	Frame_Shift_Del	DEL	C	-	-			TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr11:99944959delC	uc001pga.2	+	13	1852	c.1513delC	c.(1513-1515)CCCfs	p.P505fs	CNTN5_uc009ywv.1_Frame_Shift_Del_p.P505fs|CNTN5_uc001pfz.2_Frame_Shift_Del_p.P505fs|CNTN5_uc001pgb.2_Frame_Shift_Del_p.P431fs	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	505	Ig-like C2-type 5.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		AGAGTGCAAACCCCAAGGCTC	0.358													18	8	---	---	---	---	
KIAA0284	283638	broad.mit.edu	37	14	105352885	105352890	+	In_Frame_Del	DEL	GCAGGA	-	-	rs60001925		TCGA-39-5037-01A-01D-1441-08	TCGA-39-5037-11A-01D-1441-08									Somatic	Phase_I	Capture				Illumina GAIIx	825bd82c-f8f8-4776-a7f5-713b3a574955	49c61aed-235e-47df-ad64-e31b0a84068f	g.chr14:105352885_105352890delGCAGGA	uc010axb.2	+	12	2533_2538	c.2309_2314delGCAGGA	c.(2308-2316)CGCAGGAGC>CGC	p.RS771del	INF2_uc010tyi.1_Intron|KIAA0284_uc001ypr.2_In_Frame_Del_p.RS701del|KIAA0284_uc001yps.2_In_Frame_Del_p.RS677del|KIAA0284_uc001ypt.2_5'Flank	NM_001112726	NP_001106197	Q9Y4F5	K0284_HUMAN	hypothetical protein LOC283638 isoform 1	771_772						cytoplasm|microtubule				breast(1)	1		all_cancers(154;0.115)|Melanoma(154;0.155)|all_epithelial(191;0.183)	all cancers(16;0.000472)|OV - Ovarian serous cystadenocarcinoma(23;0.00596)|Epithelial(46;0.0149)|GBM - Glioblastoma multiforme(11;0.116)	Epithelial(152;0.178)		GACAGCAGACGCAGGAGCCCCCAGGA	0.694													5	5	---	---	---	---	
