Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PTPN2	5771	broad.mit.edu	37	18	12802000	12802000	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr18:12802000T>C	ENST00000309660.5	-	8	1102	c.1009A>G	c.(1009-1011)Atg>Gtg	p.M337V	PTPN2_ENST00000591497.1_Missense_Mutation_p.M308V|PTPN2_ENST00000353319.4_Missense_Mutation_p.M337V|PTPN2_ENST00000591115.1_Missense_Mutation_p.M360V|PTPN2_ENST00000327283.3_Missense_Mutation_p.M337V	NM_002828.3	NP_002819.2	P17706	PTN2_HUMAN	protein tyrosine phosphatase, non-receptor type 2	337					interferon-gamma-mediated signaling pathway|regulation of interferon-gamma-mediated signaling pathway	endoplasmic reticulum|nucleoplasm	protein binding			breast(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(2)|prostate(1)|skin(3)	13		Lung NSC(161;8.94e-06)				GTATCTTGCATTTTAGAGGAA	0.348000													122	110					0	0	0.048971	0	0
FAT3	120114	broad.mit.edu	37	11	92533470	92533470	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr11:92533470T>C	ENST00000298047.6	+	9	7308	c.7291T>C	c.(7291-7293)Tat>Cat	p.Y2431H	FAT3_ENST00000409404.2_Missense_Mutation_p.Y2431H|FAT3_ENST00000525166.1_Missense_Mutation_p.Y2281H			Q8TDW7	FAT3_HUMAN	FAT atypical cadherin 3	2431	Cadherin 22.				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|endometrium(10)|kidney(4)|large_intestine(11)|liver(2)|lung(37)|ovary(5)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	85		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				CCGGTTGGAATATAGCATTTT	0.478000										TCGA Ovarian(4;0.039)			45	60					0	0	0.048971	0	0
SYNJ1	8867	broad.mit.edu	37	21	34067407	34067407	+	Missense_Mutation	SNP	T	T	G			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr21:34067407T>G	ENST00000382499.2	-	5	781	c.782A>C	c.(781-783)aAt>aCt	p.N261T	SYNJ1_ENST00000382491.3_Missense_Mutation_p.N222T|SYNJ1_ENST00000357345.3_Missense_Mutation_p.N222T|SYNJ1_ENST00000322229.7_Missense_Mutation_p.N222T|SYNJ1_ENST00000433931.2_Missense_Mutation_p.N261T	NM_203446.2	NP_982271.2	O43426	SYNJ1_HUMAN	synaptojanin 1	222	SAC.						inositol-polyphosphate 5-phosphatase activity|nucleotide binding|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|RNA binding			breast(1)|cervix(1)|endometrium(13)|kidney(5)|large_intestine(13)|lung(11)|ovary(4)|pancreas(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(2)	57						ACCATCATCATTTGTTCCCCG	0.358000													48	80					0	0	0.048971	0	0
ITGA6	0	broad.mit.edu	37	2	173330368	173330368	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr2:173330368C>A	ENST00000375221.2	+	2	487	c.284C>A	c.(283-285)aCg>aAg	p.T95K	AC078883.3_ENST00000417539.1_RNA|ITGA6_ENST00000409080.1_Missense_Mutation_p.T95K|ITGA6_ENST00000409532.1_5'UTR|ITGA6_ENST00000264107.7_Missense_Mutation_p.T95K|ITGA6_ENST00000264106.6_Missense_Mutation_p.T95K|ITGA6_ENST00000343713.4_Missense_Mutation_p.T95K|AC078883.3_ENST00000458314.1_RNA			P23229	ITA6_HUMAN	integrin, alpha 6	95					blood coagulation|cell adhesion|hemidesmosome assembly|integrin-mediated signaling pathway|leukocyte migration|negative regulation of apoptosis|positive regulation of apoptosis|positive regulation of phosphorylation|positive regulation of transcription from RNA polymerase II promoter	integrin complex	protein binding|receptor activity			NS(1)|breast(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(8)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	44			OV - Ovarian serous cystadenocarcinoma(117;0.0979)			GGGCCATGCACGCGGATCGAG	0.622000											OREG0015066	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	39	17					6.97489e-18	1.00438e-17	0.074837	1	0
ATP6V1A	523	broad.mit.edu	37	3	113507676	113507676	+	Missense_Mutation	SNP	G	G	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr3:113507676G>T	ENST00000273398.3	+	7	941	c.833G>T	c.(832-834)gGt>gTt	p.G278V	ATP6V1A_ENST00000538620.1_Missense_Mutation_p.G245V	NM_001690.3	NP_001681.2	P38606	VATA_HUMAN	ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A	278					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|insulin receptor signaling pathway|transferrin transport	cytosol|integral to plasma membrane|proton-transporting V-type ATPase, V1 domain	ATP binding|hydrogen ion transporting ATP synthase activity, rotational mechanism|proton-transporting ATPase activity, rotational mechanism			breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(17)|ovary(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						GTAGGATGTGGTGAAAGAGGA	0.418000													37	61					3.38236e-24	4.96999e-24	0.092188	1	0
DIP2B	57609	broad.mit.edu	37	12	51138473	51138473	+	Nonsense_Mutation	SNP	G	G	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr12:51138473G>T	ENST00000301180.5	+	38	4616	c.4582G>T	c.(4582-4584)Gaa>Taa	p.E1528*		NM_173602.2	NP_775873.2	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B (Drosophila)	1528						nucleus	catalytic activity|transcription factor binding			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(4)|large_intestine(15)|lung(18)|ovary(4)|pancreas(1)|prostate(1)|skin(6)|urinary_tract(2)	60						CGTGGTCCTGGAAGAGCATTA	0.547000													16	55					6.72482e-11	9.13561e-11	0.024245	1	0
UBAP2	55833	broad.mit.edu	37	9	33989021	33989021	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr9:33989021C>T	ENST00000379238.1	-	5	509	c.392G>A	c.(391-393)gGa>gAa	p.G131E	UBAP2_ENST00000360802.1_Missense_Mutation_p.G131E|UBAP2_ENST00000449054.1_Missense_Mutation_p.G131E|UBAP2_ENST00000418786.2_Missense_Mutation_p.G131E|UBAP2_ENST00000379239.4_5'UTR|UBAP2_ENST00000539807.1_Intron			Q5T6F2	UBAP2_HUMAN	ubiquitin associated protein 2	131										endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(7)|lung(13)|ovary(3)|stomach(1)	32			LUSC - Lung squamous cell carcinoma(29;0.00575)	GBM - Glioblastoma multiforme(74;0.168)		GTTTCCACGTCCACGACTCGA	0.403000													6	183					0	0	0.029380	0	0
SEC14L5	9717	broad.mit.edu	37	16	5038269	5038269	+	Missense_Mutation	SNP	C	C	G			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr16:5038269C>G	ENST00000251170.7	+	4	513	c.333C>G	c.(331-333)caC>caG	p.H111Q		NM_014692.1	NP_055507.1	O43304	S14L5_HUMAN	SEC14-like 5 (S. cerevisiae)	111	PRELI/MSF1.					integral to membrane|intracellular	transporter activity			NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(7)|lung(9)|ovary(1)|skin(1)	29						TGAACGAGCACTGCAGCTACA	0.632000													10	31					0	0	0.069234	0	0
TRPV2	51393	broad.mit.edu	37	17	16321003	16321003	+	Silent	SNP	T	T	C			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr17:16321003T>C	ENST00000338560.7	+	2	420	c.21T>C	c.(19-21)tcT>tcC	p.S7S	TRPV2_ENST00000577397.1_5'UTR	NM_016113.4	NP_057197.2	Q9Y5S1	TRPV2_HUMAN	transient receptor potential cation channel, subfamily V, member 2	7	Required for interaction with SLC50A1 (By similarity).				sensory perception	integral to plasma membrane|melanosome	calcium channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(7)|lung(9)|ovary(1)|pancreas(1)|prostate(2)|stomach(3)	28				UCEC - Uterine corpus endometrioid carcinoma (92;0.0837)		CCTCCAGCTCTCCAGTTTTCA	0.577000													3	76					0	0	0.004672	0	0
CDK17	5128	broad.mit.edu	37	12	96677410	96677410	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr12:96677410C>T	ENST00000261211.3	-	14	1939	c.1336G>A	c.(1336-1338)Gga>Aga	p.G446R	CDK17_ENST00000543119.2_Missense_Mutation_p.G446R|CDK17_ENST00000542666.1_Missense_Mutation_p.G393R	NM_001170464.2|NM_002595.4	NP_001163935.1|NP_002586.2	Q00537	CDK17_HUMAN	cyclin-dependent kinase 17	446	Protein kinase.						ATP binding|cyclin-dependent protein kinase activity			breast(1)|central_nervous_system(1)|endometrium(8)|kidney(3)|large_intestine(6)|lung(11)|ovary(4)|prostate(2)|skin(1)	37						AACTCAATTCCTTCAGAGTCT	0.313000													6	95					0	0	0.021553	0	0
ARHGEF10	9639	broad.mit.edu	37	8	1844605	1844605	+	Missense_Mutation	SNP	A	A	C			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr8:1844605A>C	ENST00000518288.1	+	15	1785	c.1622A>C	c.(1621-1623)gAa>gCa	p.E541A	ARHGEF10_ENST00000520359.1_Missense_Mutation_p.E478A|ARHGEF10_ENST00000262112.6_Missense_Mutation_p.E541A|ARHGEF10_ENST00000398564.1_Missense_Mutation_p.E541A|ARHGEF10_ENST00000398560.1_Missense_Mutation_p.E502A|ARHGEF10_ENST00000349830.3_Missense_Mutation_p.E516A			O15013	ARHGA_HUMAN	Rho guanine nucleotide exchange factor (GEF) 10	541	DH.				centrosome duplication|myelination in peripheral nervous system|positive regulation of GTP catabolic process|positive regulation of stress fiber assembly|regulation of Rho protein signal transduction|spindle assembly involved in mitosis	centrosome|cytosol|soluble fraction	kinesin binding|Rho guanyl-nucleotide exchange factor activity			endometrium(3)|large_intestine(11)|lung(11)|prostate(3)|skin(3)|stomach(3)|urinary_tract(1)	35		Colorectal(14;3.46e-05)|Renal(68;0.000518)|Ovarian(12;0.00409)|Myeloproliferative disorder(644;0.0255)|Hepatocellular(245;0.0834)		COAD - Colon adenocarcinoma(149;1.62e-05)|BRCA - Breast invasive adenocarcinoma(11;1.68e-05)|KIRC - Kidney renal clear cell carcinoma(542;0.00361)|READ - Rectum adenocarcinoma(644;0.0718)		GCTTTTCTTGAATTTTTAAAG	0.388000													4	82					0	0	0.009096	0	0
DGKH	160851	broad.mit.edu	37	13	42742922	42742922	+	Silent	SNP	A	A	G			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr13:42742922A>G	ENST00000379274.2	+	11	1356	c.927A>G	c.(925-927)aaA>aaG	p.K309K	DGKH_ENST00000538674.1_Silent_p.K200K|DGKH_ENST00000536612.1_Silent_p.K309K|DGKH_ENST00000337343.4_Silent_p.K445K|DGKH_ENST00000540693.1_Silent_p.K445K|DGKH_ENST00000498255.2_3'UTR|DGKH_ENST00000261491.4_Silent_p.K445K			Q86XP1	DGKH_HUMAN	diacylglycerol kinase, eta	445					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation|protein oligomerization	endosome|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			breast(2)|endometrium(3)|kidney(5)|large_intestine(11)|lung(9)|ovary(4)|pancreas(1)|prostate(1)|skin(2)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	43		Lung NSC(96;1.02e-05)|Prostate(109;0.0168)|Lung SC(185;0.0262)|Breast(139;0.0709)|Hepatocellular(98;0.114)		OV - Ovarian serous cystadenocarcinoma(117;5.88e-05)|GBM - Glioblastoma multiforme(144;0.000935)|BRCA - Breast invasive adenocarcinoma(63;0.109)		TCCTAGAGAAACTGGAACGAG	0.423000													37	15					0	0	0.074837	0	0
MEF2C	4208	broad.mit.edu	37	5	88027604	88027604	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr5:88027604C>T	ENST00000504921.2	-	7	1424	c.752G>A	c.(751-753)cGt>cAt	p.R251H	MEF2C_ENST00000514015.1_Missense_Mutation_p.R251H|MEF2C_ENST00000510942.1_Missense_Mutation_p.R251H|MEF2C_ENST00000508569.1_Missense_Mutation_p.R251H|MEF2C_ENST00000424173.2_Missense_Mutation_p.R249H|MEF2C_ENST00000437473.2_Missense_Mutation_p.R251H|MEF2C_ENST00000340208.5_Missense_Mutation_p.R269H|MEF2C_ENST00000539796.1_Missense_Mutation_p.R203H|MEF2C_ENST00000514028.1_Missense_Mutation_p.R251H|MEF2C_ENST00000506554.1_Missense_Mutation_p.R251H			Q06413	MEF2C_HUMAN	myocyte enhancer factor 2C	251					apoptosis|B cell proliferation|innate immune response|learning or memory|muscle cell differentiation|muscle organ development|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|neuron development|positive regulation of muscle cell differentiation|positive regulation of survival gene product expression|positive regulation of transcription from RNA polymerase II promoter|regulation of germinal center formation|regulation of megakaryocyte differentiation|regulation of synaptic activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	nuclear speck	activating transcription factor binding|protein heterodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			breast(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(9)|lung(9)|ovary(2)|pancreas(1)|prostate(4)|skin(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	40		all_cancers(142;6.67e-05)|all_epithelial(76;7.77e-07)|Lung NSC(167;0.00566)|all_lung(232;0.00732)|Colorectal(57;0.0959)|Ovarian(174;0.1)		OV - Ovarian serous cystadenocarcinoma(54;1.04e-33)|Epithelial(54;1.6e-28)|all cancers(79;2.9e-25)		ATCTGGTTTACGGTTATTCAT	0.388000										HNSCC(66;0.2)			19	30					0	0	0.062417	0	0
TUBB8P7	0	broad.mit.edu	37	16	90161926	90161926	+	RNA	SNP	T	T	C	rs8061283	by1000genomes	TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr16:90161926T>C	ENST00000567960.1	+	0	662				TUBB8P7_ENST00000564451.1_RNA														p.I221T(3)									CCCACACCCATCTATGGTGAC	0.527000													3	49					0	0	0.009096	0	0
RP11-156P1.3	0	broad.mit.edu	37	17	45127107	45127107	+	RNA	SNP	C	C	G	rs147409399	by1000genomes	TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr17:45127107C>G	ENST00000575173.1	-	0	418																											CCTTCGTTCACCCAAGAGCAT	0.592000													4	116					0	0	0.009096	0	0
ATOH1	474	broad.mit.edu	37	4	94750645	94750645	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr4:94750645A>G	ENST00000306011.3	+	1	604	c.568A>G	c.(568-570)Aac>Gac	p.N190D		NM_005172.1	NP_005163.1	Q92858	ATOH1_HUMAN	atonal homolog 1 (Drosophila)	190	Helix-loop-helix motif.				transcription from RNA polymerase II promoter	nucleus	sequence-specific DNA binding transcription factor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(2)|skin(1)|upper_aerodigestive_tract(1)	11		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;3.57e-07)		CCCGTCGTTCAACAACGACAA	0.577000													31	39					0	0	0.037714	0	0
ZFPM2	23414	broad.mit.edu	37	8	106813420	106813420	+	Silent	SNP	C	C	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr8:106813420C>T	ENST00000407775.2	+	8	1360	c.1110C>T	c.(1108-1110)ttC>ttT	p.F370F	ZFPM2_ENST00000378472.4_Silent_p.F101F|RP11-152P17.2_ENST00000521622.1_RNA|RP11-152P17.2_ENST00000524045.2_RNA|ZFPM2_ENST00000522296.1_3'UTR|ZFPM2_ENST00000520492.1_Silent_p.F238F|RP11-152P17.2_ENST00000518932.1_RNA|RP11-152P17.2_ENST00000509144.2_RNA|RP11-152P17.2_ENST00000520433.1_RNA|ZFPM2_ENST00000517361.1_Silent_p.F238F|RP11-152P17.2_ENST00000520594.1_RNA	NM_012082.3	NP_036214.2	Q8WW38	FOG2_HUMAN	zinc finger protein, FOG family member 2	370					blood coagulation|negative regulation of fat cell differentiation|outflow tract septum morphogenesis|right ventricular cardiac muscle tissue morphogenesis|ventricular septum morphogenesis	nucleoplasm	DNA binding|RNA polymerase II transcription coactivator activity|transcription corepressor activity|transcription factor binding|zinc ion binding			NS(4)|breast(6)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(11)|liver(2)|lung(48)|ovary(4)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	99			OV - Ovarian serous cystadenocarcinoma(57;8.28e-08)			ACTGCCATTTCGGCTTCCAGA	0.512000													9	196					0	0	0.069234	0	0
CDC42BPB	9578	broad.mit.edu	37	14	103442221	103442221	+	Splice_Site	SNP	T	T	G			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr14:103442221T>G	ENST00000361246.2	-	10	1674	c.1387_splice	c.e10+1	p.Q462_splice		NM_006035.3	NP_006026.3	Q9Y5S2	MRCKB_HUMAN	CDC42 binding protein kinase beta (DMPK-like)	462					actin cytoskeleton reorganization|establishment or maintenance of cell polarity|intracellular signal transduction	cell leading edge|cell-cell junction|cytoplasm|cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity|small GTPase regulator activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(6)|kidney(3)|large_intestine(11)|liver(1)|lung(14)|ovary(2)|prostate(2)|skin(3)|stomach(1)	49		Melanoma(154;0.155)		Colorectal(3;0.0129)|READ - Rectum adenocarcinoma(2;0.0419)|Epithelial(152;0.0474)|all cancers(159;0.199)		TGCCCTCACCTTGCAGCTTCC	0.662000													8	128					0	0	0.038147	0	0
LRP4	4038	broad.mit.edu	37	11	46889635	46889635	+	Missense_Mutation	SNP	G	G	C			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr11:46889635G>C	ENST00000378623.1	-	34	5224	c.4982C>G	c.(4981-4983)gCt>gGt	p.A1661G	LRP4-AS1_ENST00000531719.1_RNA|LRP4-AS1_ENST00000502049.2_RNA	NM_002334.3	NP_002325.2	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein 4	1661					endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			breast(7)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(13)|lung(24)|ovary(3)|pancreas(2)|prostate(5)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)	70				Lung(87;0.159)		CATGCCAGTAGCCCTAGGAGC	0.537000													4	85					0	0	0.009096	0	0
CCDC180	100499483	broad.mit.edu	37	9	100128910	100128910	+	Missense_Mutation	SNP	G	G	A	rs147885690		TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr9:100128910G>A	ENST00000375202.2	+	45	5601	c.4249G>A	c.(4249-4251)Gcc>Acc	p.A1417T	RP11-23J9.4_ENST00000534123.1_RNA|CCDC180_ENST00000395220.1_3'UTR|CCDC180_ENST00000357054.1_Missense_Mutation_p.A1362T|CCDC180_ENST00000529487.1_Missense_Mutation_p.A1417T					coiled-coil domain containing 180																		TGACCAGTGCGCCGAGAACAT	0.532000													4	46					0	0	0.014758	0	0
COL11A1	1301	broad.mit.edu	37	1	103404601	103404601	+	Missense_Mutation	SNP	T	T	G			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr1:103404601T>G	ENST00000358392.2	-	44	3781	c.3464A>C	c.(3463-3465)aAg>aCg	p.K1155T	COL11A1_ENST00000512756.1_Missense_Mutation_p.K1027T|COL11A1_ENST00000353414.4_Missense_Mutation_p.K1104T|COL11A1_ENST00000370096.3_Missense_Mutation_p.K1143T	NM_080629.2	NP_542196.2	P12107	COBA1_HUMAN	collagen, type XI, alpha 1	1143	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			NS(3)|biliary_tract(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(17)|kidney(8)|large_intestine(28)|lung(157)|ovary(6)|pancreas(2)|prostate(6)|skin(9)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(1)	258		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		ATTTTCTCCCTTGTCACCCTT	0.338000													4	63					0	0	0.014758	0	0
OR10J1	26476	broad.mit.edu	37	1	159409943	159409943	+	Missense_Mutation	SNP	A	A	G			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr1:159409943A>G	ENST00000423932.3	+	1	432	c.395A>G	c.(394-396)gAc>gGc	p.D132G	RP11-550P17.5_ENST00000431862.1_RNA	NM_012351.2	NP_036483.2	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J, member 1	132					sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			endometrium(2)|kidney(1)|large_intestine(5)|lung(13)|ovary(1)|skin(2)|stomach(1)	25	all_hematologic(112;0.0429)					ATGGGATATGACCGCTATGTG	0.498000													3	130					0	0	0.004672	0	0
SENP7	57337	broad.mit.edu	37	3	101047392	101047392	+	Splice_Site	SNP	T	T	C			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr3:101047392T>C	ENST00000394095.2	-	22	2849		c.e22-2		SENP7_ENST00000348610.3_Splice_Site|SENP7_ENST00000358203.3_Splice_Site|SENP7_ENST00000394085.3_Splice_Site|SENP7_ENST00000314261.7_Splice_Site|SENP7_ENST00000394094.2_Splice_Site|SENP7_ENST00000394091.1_Splice_Site	NM_020654.3	NP_065705.3	Q9BQF6	SENP7_HUMAN	SUMO1/sentrin specific peptidase 7						proteolysis	nucleus	cysteine-type peptidase activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(16)|lung(15)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	44						ATACATGGCCTATGAAAAGCA	0.318000													3	173					0	0	0.004672	0	0
SOBP	55084	broad.mit.edu	37	6	107824969	107824969	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr6:107824969G>A	ENST00000317357.5	+	2	864	c.205G>A	c.(205-207)Gag>Aag	p.E69K		NM_018013.3	NP_060483.3	A7XYQ1	SOBP_HUMAN	sine oculis binding protein homolog (Drosophila)	69							metal ion binding			endometrium(1)|kidney(2)|large_intestine(4)|lung(15)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	26		all_cancers(87;5.26e-06)|Acute lymphoblastic leukemia(125;2.87e-08)|all_hematologic(75;1.14e-06)|all_epithelial(87;0.00193)|Colorectal(196;0.156)		BRCA - Breast invasive adenocarcinoma(108;0.026)|all cancers(137;0.087)|Epithelial(106;0.104)|OV - Ovarian serous cystadenocarcinoma(136;0.154)		TACAGATGGGGAGAGCCGGCA	0.403000													6	94					0	0	0.029380	0	0
TCAP	8557	broad.mit.edu	37	17	37821715	37821715	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr17:37821715G>A	ENST00000309889.2	+	1	1276	c.103G>A	c.(103-105)Gag>Aag	p.E35K	TCAP_ENST00000578283.1_Missense_Mutation_p.E35K			O15273	TELT_HUMAN	titin-cap	35					adult heart development|cardiac muscle contraction|cardiac muscle fiber development|cardiac muscle tissue morphogenesis|detection of mechanical stimulus|muscle filament sliding|response to stress|sarcomere organization|skeletal muscle contraction|skeletal muscle myosin thick filament assembly|skeletal muscle thin filament assembly	cytosol|Z disc	structural constituent of muscle|titin binding|titin Z domain binding			kidney(1)|lung(1)	2	all_cancers(6;6.59e-85)|all_epithelial(6;2.89e-103)|Breast(7;1.05e-86)|Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;3.87e-45)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CACACGGCCCGAGGAGGGGTG	0.617000													29	43					0	0	0.037714	0	0
LILRA3	0	broad.mit.edu	37	19	54802486	54802486	+	Missense_Mutation	SNP	T	T	C			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr19:54802486T>C	ENST00000391745.1	-	9	1322	c.1006A>G	c.(1006-1008)Aca>Gca	p.T336A	LILRA3_ENST00000251390.3_Missense_Mutation_p.T319A|LILRA3_ENST00000391744.3_Missense_Mutation_p.T255A					leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3											NS(3)|breast(1)|kidney(1)|large_intestine(3)|lung(12)|ovary(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	28	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(193;0.105)		TCCTCACCTGTGATCAGGATG	0.682000													3	45					0	0	0.014758	0	0
ROBO1	6091	broad.mit.edu	37	3	78667056	78667056	+	Silent	SNP	C	C	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr3:78667056C>T	ENST00000436010.2	-	25	4891	c.3894G>A	c.(3892-3894)gaG>gaA	p.E1298E	ROBO1_ENST00000464233.1_Silent_p.E1337E|ROBO1_ENST00000467549.1_Silent_p.E1237E|ROBO1_ENST00000495273.1_Silent_p.E1292E			Q9Y6N7	ROBO1_HUMAN	roundabout, axon guidance receptor, homolog 1 (Drosophila)	1337					activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(25)|urinary_tract(1)	44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		TCTTGGCTACCTCCATGTCGG	0.547000													41	45					0	0	0.042209	0	0
SLC50A1	55974	broad.mit.edu	37	1	155110477	155110477	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr1:155110477C>T	ENST00000368404.4	+	5	529	c.467C>T	c.(466-468)tCa>tTa	p.S156L	SLC50A1_ENST00000368405.3_3'UTR|SLC50A1_ENST00000368401.5_Missense_Mutation_p.S101L|SLC50A1_ENST00000303343.8_Missense_Mutation_p.S102L|SLC50A1_ENST00000484157.1_Missense_Mutation_p.S91L	NM_018845.3	NP_061333.2	Q9BRV3	SWET1_HUMAN	solute carrier family 50 (sugar efflux transporter), member 1	156	Mediates interaction with TRPV2 (By similarity).|MtN3/slv 2.				positive regulation of gene expression, epigenetic	Golgi membrane|integral to membrane|plasma membrane	glucoside transmembrane transporter activity			endometrium(1)|lung(1)|ovary(1)|skin(1)	4						CAAACTAAATCAACCCAATGT	0.463000													56	62					0	0	0.048971	0	0
TNXB	7148	broad.mit.edu	37	6	32053654	32053654	+	Silent	SNP	C	C	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr6:32053654C>A	ENST00000375244.3	-	7	3222	c.3021G>T	c.(3019-3021)gtG>gtT	p.V1007V	TNXB_ENST00000375247.2_Silent_p.V1007V			P22105	TENX_HUMAN	tenascin XB	1094	Fibronectin type-III 2.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						CCCCTGGCAGCACTTCCTCAT	0.682000													5	109					0.000602214	0.000788353	0.014758	1	0
MFI2	4241	broad.mit.edu	37	3	196744089	196744089	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr3:196744089C>T	ENST00000296350.5	-	7	898	c.785G>A	c.(784-786)cGg>cAg	p.R262Q		NM_005929.5	NP_005920.2	P08582	TRFM_HUMAN	antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5	262	Transferrin-like 1.				cellular iron ion homeostasis|iron ion transport	anchored to membrane|extracellular region|integral to plasma membrane	ferric iron binding|protein binding			breast(2)|endometrium(3)|kidney(2)|large_intestine(2)|lung(10)|prostate(1)	20	all_cancers(143;3.95e-09)|Ovarian(172;0.0634)|Breast(254;0.0838)		Epithelial(36;4.55e-24)|all cancers(36;2.87e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00536)		GACATCGGCCCGGCTACCATC	0.687000													10	14					0	0	0.058154	0	0
TMPRSS11D	9407	broad.mit.edu	37	4	68719844	68719844	+	Missense_Mutation	SNP	T	T	G			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr4:68719844T>G	ENST00000283916.6	-	3	289	c.191A>C	c.(190-192)cAg>cCg	p.Q64P	TMPRSS11D_ENST00000545541.1_5'UTR|RP11-453E17.1_ENST00000500538.2_RNA|TMPRSS11D_ENST00000509584.1_5'UTR	NM_004262.2	NP_004253.1	O60235	TM11D_HUMAN	transmembrane protease, serine 11D	64	SEA.				proteolysis|respiratory gaseous exchange	extracellular region|integral to plasma membrane	serine-type endopeptidase activity			cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23						TGAATTTAACTGACTATTATA	0.303000													6	79					0	0	0.021553	0	0
OTOA	146183	broad.mit.edu	37	16	21726417	21726417	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr16:21726417G>A	ENST00000388958.3	+	13	1433	c.1432G>A	c.(1432-1434)Gtc>Atc	p.V478I	OTOA_ENST00000388956.4_Missense_Mutation_p.V399I|OTOA_ENST00000286149.4_Missense_Mutation_p.V492I|OTOA_ENST00000388957.3_Missense_Mutation_p.V154I	NM_144672.3	NP_653273.3	Q7RTW8	OTOAN_HUMAN	otoancorin	492					sensory perception of sound	anchored to membrane|apical plasma membrane|proteinaceous extracellular matrix		p.V478I(1)		breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(9)|liver(2)|lung(23)|ovary(1)|prostate(1)|skin(5)|stomach(1)	46				GBM - Glioblastoma multiforme(48;0.0414)		GAGAAGTGCCGTCTCCCAGTA	0.577000													18	252					0	0	0.055883	0	0
ATG14	22863	broad.mit.edu	37	14	55848836	55848836	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr14:55848836G>A	ENST00000247178.5	-	6	756	c.721C>T	c.(721-723)Cgg>Tgg	p.R241W		NM_014924.4	NP_055739.2	Q6ZNE5	BAKOR_HUMAN	autophagy related 14	241					autophagic vacuole assembly|positive regulation of autophagy	autophagic vacuole|endoplasmic reticulum|pre-autophagosomal structure membrane	protein binding			central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(6)|prostate(2)	13						GTTGTCCTCCGGGCTTCAGCA	0.527000													56	62					0	0	0.048971	0	0
TUBB8P7	0	broad.mit.edu	37	16	90161902	90161902	+	RNA	SNP	A	A	G	rs6500471	by1000genomes	TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr16:90161902A>G	ENST00000567960.1	+	0	638				TUBB8P7_ENST00000564451.1_RNA														p.K213R(8)									ATATGTTCCAAGACCCTAAAA	0.537000													3	51					0	0	0.009096	0	0
INTS1	26173	broad.mit.edu	37	7	1542704	1542704	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr7:1542704G>A	ENST00000389470.4	-	4	565	c.566C>T	c.(565-567)gCg>gTg	p.A189V	INTS1_ENST00000404767.3_Missense_Mutation_p.A61V			Q8N201	INT1_HUMAN	integrator complex subunit 1	61					snRNA processing	integral to membrane|integrator complex|nuclear membrane				autonomic_ganglia(1)|cervix(1)|endometrium(14)|kidney(3)|large_intestine(7)|lung(24)|ovary(1)|prostate(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	62		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		CGCGGCCGCCGCATCCCGCTT	0.657000													5	110					0	0	0.014758	0	0
KIR3DX1	0	broad.mit.edu	37	19	55046936	55046936	+	Missense_Mutation	SNP	C	C	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr19:55046936C>A	ENST00000335056.3	+	4	519	c.481C>A	c.(481-483)Cat>Aat	p.H161N	KIR3DX1_ENST00000482404.1_3'UTR																endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|skin(1)	24				GBM - Glioblastoma multiforme(193;0.099)		GCACATACAGCATTCCCAGCA	0.557000													20	44					4.96729e-08	6.62305e-08	0.049695	1	0
SPOP	8405	broad.mit.edu	37	17	47696432	47696432	+	Missense_Mutation	SNP	A	A	C			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr17:47696432A>C	ENST00000393331.3	-	7	861	c.391T>G	c.(391-393)Tgg>Ggg	p.W131G	SPOP_ENST00000393328.2_Missense_Mutation_p.W131G|SPOP_ENST00000347630.2_Missense_Mutation_p.W131G|SPOP_ENST00000504102.1_Missense_Mutation_p.W131G|SPOP_ENST00000503676.1_Missense_Mutation_p.W131G	NM_001007226.1|NM_001007227.1	NP_001007227.1|NP_001007228.1	O43791	SPOP_HUMAN	speckle-type POZ protein	131	MATH.|Required for nuclear localization.				mRNA processing	nucleus	protein binding	p.W131G(2)|p.W131R(1)		endometrium(18)|kidney(1)|large_intestine(3)|liver(1)|lung(4)|ovary(3)|prostate(33)	63						TTGAATCCCCAGTCTTTGCCT	0.458000										Prostate(2;0.17)			79	106					0	0	0.048971	0	0
GLI1	2735	broad.mit.edu	37	12	57864192	57864192	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr12:57864192C>T	ENST00000228682.2	+	12	1760	c.1669C>T	c.(1669-1671)Cgc>Tgc	p.R557C	GLI1_ENST00000546141.1_Missense_Mutation_p.R516C|GLI1_ENST00000543426.1_Missense_Mutation_p.R429C	NM_005269.2	NP_005260.1	P08151	GLI1_HUMAN	GLI family zinc finger 1	557					epidermal cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|osteoblast differentiation|positive regulation of DNA replication|positive regulation of smoothened signaling pathway|positive regulation of transcription from RNA polymerase II promoter	cytosol|nucleus	transcription regulatory region DNA binding|zinc ion binding			NS(1)|breast(7)|central_nervous_system(1)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(8)|lung(22)|ovary(6)|pancreas(2)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	69			GBM - Glioblastoma multiforme(3;3.99e-32)			TACTGTCAGCCGCCGCTCCTC	0.647000													43	74					0	0	0.045515	0	0
TBC1D14	57533	broad.mit.edu	37	4	6995922	6995922	+	Silent	SNP	C	C	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr4:6995922C>T	ENST00000409757.4	+	4	979	c.855C>T	c.(853-855)gaC>gaT	p.D285D	TBC1D14_ENST00000451522.2_Silent_p.D5D|TBC1D14_ENST00000410031.1_Silent_p.D57D|TBC1D14_ENST00000448507.1_Silent_p.D285D	NM_020773.2	NP_065824.2	Q9P2M4	TBC14_HUMAN	TBC1 domain family, member 14	285						intracellular	Rab GTPase activator activity			breast(1)|endometrium(5)|large_intestine(4)|lung(9)|ovary(1)|pancreas(1)|upper_aerodigestive_tract(1)	22						aatatgaagacaaggctggaa	0.458000													8	94					0	0	0.038147	0	0
RP9	6100	broad.mit.edu	37	7	33138944	33138944	+	Silent	SNP	C	C	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr7:33138944C>T	ENST00000297157.3	-	3	305	c.288G>A	c.(286-288)ctG>ctA	p.L96L		NM_203288.1	NP_976033.1	Q8TA86	RP9_HUMAN	retinitis pigmentosa 9 (autosomal dominant)	96	PIM1-binding (By similarity).				RNA splicing	nucleus	nucleic acid binding|protein binding|zinc ion binding			large_intestine(3)|lung(3)|urinary_tract(1)	7			GBM - Glioblastoma multiforme(11;0.0403)			CTTCTTTCCCCAGTGGCATCC	0.428000													4	151					0	0	0.014758	0	0
TGFA	7039	broad.mit.edu	37	2	70680366	70680366	+	Silent	SNP	G	G	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr2:70680366G>A	ENST00000295400.6	-	5	706	c.459C>T	c.(457-459)tgC>tgT	p.C153C	TGFA_ENST00000445399.1_Silent_p.C152C|TGFA_ENST00000444975.1_Silent_p.C159C|TGFA_ENST00000450929.1_Silent_p.C158C|TGFA_ENST00000418333.2_Silent_p.C152C	NM_001099691.2|NM_003236.3	NP_001093161.1|NP_003227.1	P01135	TGFA_HUMAN	transforming growth factor, alpha	153					activation of MAPK activity|cell proliferation|positive regulation of cell division|positive regulation of epidermal growth factor receptor activity|positive regulation of epithelial cell proliferation|positive regulation of mitosis	cell surface|extracellular space|integral to membrane|plasma membrane	epidermal growth factor receptor binding|growth factor activity|MAP kinase kinase activity|signal transducer activity			haematopoietic_and_lymphoid_tissue(1)|lung(2)|prostate(1)	4						CTGAGTGGCAGCAAGCGGTTC	0.577000													4	171					0	0	0.014758	0	0
APBA1	320	broad.mit.edu	37	9	72131395	72131395	+	Silent	SNP	G	G	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr9:72131395G>A	ENST00000265381.4	-	2	954	c.732C>T	c.(730-732)ggC>ggT	p.G244G		NM_001163.3	NP_001154.2	Q02410	APBA1_HUMAN	amyloid beta (A4) precursor protein-binding, family A, member 1	244	Munc-18-1 binding.				axon cargo transport|cell adhesion|intracellular protein transport|nervous system development|protein complex assembly|synaptic transmission	synaptic vesicle				endometrium(4)|kidney(2)|large_intestine(12)|lung(13)|prostate(3)|skin(3)	37						TGTCGGACTCGCCGTCGGAGC	0.701000													24	23					0	0	0.099896	0	0
KIN	22944	broad.mit.edu	37	10	7808017	7808017	+	Splice_Site	SNP	G	G	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr10:7808017G>T	ENST00000379562.3	-	9	895	c.849_splice	c.e9+1	p.P283_splice	KIN_ENST00000463666.1_5'UTR|KIN_ENST00000535925.1_Splice_Site_p.P283_splice|KIN_ENST00000543003.1_Splice_Site_p.P177_splice			O60870	KIN17_HUMAN	KIN, antigenic determinant of recA protein homolog (mouse)	283					DNA recombination|DNA repair|DNA replication|interspecies interaction between organisms|mRNA processing	cytoplasm|nuclear matrix	double-stranded DNA binding|RNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(3)|lung(9)|ovary(1)|pancreas(1)|skin(2)	19						AATACTTACAGGCTGTAGCCA	0.328000													11	42					6.42651e-13	8.89825e-13	0.080935	1	0
RLBP1	6017	broad.mit.edu	37	15	89760395	89760395	+	Missense_Mutation	SNP	C	C	T			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr15:89760395C>T	ENST00000268125.5	-	5	741	c.302G>A	c.(301-303)cGc>cAc	p.R101H		NM_000326.4	NP_000317.1	P12271	RLBP1_HUMAN	retinaldehyde binding protein 1	101					response to stimulus|visual perception|vitamin A metabolic process	cytoplasm|soluble fraction	retinol binding|transporter activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(1)|prostate(1)|skin(1)	18	Lung NSC(78;0.0472)|all_lung(78;0.089)				Vitamin A(DB00162)	CTTCCGTGCGCGGATGAAGCG	0.667000													22	35					0	0	0.062417	0	0
PDE7A	5150	broad.mit.edu	37	8	66753620	66753620	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr8:66753620G>A	ENST00000401827.3	-	1	567	c.124C>T	c.(124-126)Cgg>Tgg	p.R42W	PDE7A_ENST00000396642.3_Missense_Mutation_p.R42W	NM_001242318.2	NP_001229247.1	Q13946	PDE7A_HUMAN	phosphodiesterase 7A	42						cell fraction|cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding			large_intestine(5)|lung(3)|stomach(1)|urinary_tract(1)	10			Epithelial(68;0.0509)|BRCA - Breast invasive adenocarcinoma(89;0.111)|all cancers(69;0.168)|OV - Ovarian serous cystadenocarcinoma(28;0.238)		Dyphylline(DB00651)|Ketotifen(DB00920)	GAGAGCTGCCGGGGATTGGGG	0.657000													17	32					0	0	0.043863	0	0
EFHC2	80258	broad.mit.edu	37	X	44171919	44171919	+	Silent	SNP	T	T	C			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chrX:44171919T>C	ENST00000420999.1	-	2	209	c.126A>G	c.(124-126)ggA>ggG	p.G42G		NM_025184.3	NP_079460.2	Q5JST6	EFHC2_HUMAN	EF-hand domain (C-terminal) containing 2	42							calcium ion binding			NS(1)|breast(7)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(2)|skin(1)|urinary_tract(1)	29						CTCCACCTATTCCAGGCTTTT	0.418000													24	2					0	0	0.076483	0	0
COL6A3	1293	broad.mit.edu	37	2	238243486	238243486	+	Silent	SNP	G	G	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr2:238243486G>A	ENST00000295550.4	-	41	9464	c.9012C>T	c.(9010-9012)agC>agT	p.S3004S	COL6A3_ENST00000347401.3_Silent_p.S2803S|COL6A3_ENST00000353578.4_Silent_p.S2798S|COL6A3_ENST00000472056.1_Silent_p.S2397S|COL6A3_ENST00000346358.4_Silent_p.S2804S|COL6A3_ENST00000409809.1_Silent_p.S2798S	NM_004369.3	NP_004360.2	P12111	CO6A3_HUMAN	collagen, type VI, alpha 3	3004	Fibronectin type-III.|Nonhelical region.				axon guidance|cell adhesion|muscle organ development	collagen type VI|extracellular space	serine-type endopeptidase inhibitor activity			breast(6)|central_nervous_system(7)|cervix(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(13)|large_intestine(64)|lung(62)|ovary(14)|pancreas(2)|prostate(11)|skin(14)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(4)	217		Breast(86;0.000301)|Renal(207;0.000966)|all_hematologic(139;0.067)|Ovarian(221;0.0694)|all_lung(227;0.0943)|Melanoma(123;0.203)		Epithelial(121;1.23e-21)|OV - Ovarian serous cystadenocarcinoma(60;1.34e-10)|Kidney(56;5.71e-09)|KIRC - Kidney renal clear cell carcinoma(57;1.51e-07)|BRCA - Breast invasive adenocarcinoma(100;0.00025)|Lung(119;0.0142)|LUSC - Lung squamous cell carcinoma(224;0.034)		GGAGTTTGGCGCTGTTCTCTG	0.483000													13	90					0	0	0.020292	0	0
WAPAL	23063	broad.mit.edu	37	10	88232463	88232463	+	Missense_Mutation	SNP	G	G	A			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr10:88232463G>A	ENST00000298767.5	-	6	2271	c.1799C>T	c.(1798-1800)gCa>gTa	p.A600V		NM_015045.2	NP_055860.1	Q7Z5K2	WAPL_HUMAN	wings apart-like homolog (Drosophila)	600	Mediates interaction with the cohesin complex.				cell division|interspecies interaction between organisms|mitosis|negative regulation of chromatin binding|negative regulation of DNA replication|negative regulation of sister chromatid cohesion|protein localization to chromatin|regulation of cohesin localization to chromatin	chromatin|cohesin complex|cytoplasm	protein binding			breast(2)|endometrium(2)|kidney(5)|large_intestine(6)|lung(13)|ovary(2)|stomach(1)	31						GGATGGTGGTGCAGGAGCCTT	0.358000													36	28					0	0	0.080422	0	0
SPINK1	6690	broad.mit.edu	37	5	147204248	147204250	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr5:147204248_147204250delGAG	ENST00000296695.5	-	4	422_424	c.214_216delCTC	c.(214-216)del	p.L72del		NM_003122.3	NP_003113.2	P00995	ISK1_HUMAN	serine peptidase inhibitor, Kazal type 1	72	Kazal-like.					extracellular region	protein binding|serine-type endopeptidase inhibitor activity			endometrium(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			ATTTTTGAATGAGGATAGAAGTC	0.399									Hereditary Pancreatitis				8	85	---	---	---	---					
CC2D2B	387707	broad.mit.edu	37	10	97779073	97779076	+	Frame_Shift_Del	DEL	TTGT	TTGT	-			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr10:97779073_97779076delTTGT	ENST00000344386.3	+	7	800_803	c.636_639delTTGT	c.(634-639)gafs	p.DC212fs	RP11-690P14.4_ENST00000475252.2_Intron|ENTPD1-AS1_ENST00000454638.1_RNA|ENTPD1-AS1_ENST00000416301.1_RNA|CC2D2B_ENST00000371198.2_Intron|ENTPD1-AS1_ENST00000458228.1_RNA|ENTPD1-AS1_ENST00000451364.1_RNA|ENTPD1-AS1_ENST00000452728.1_RNA|CC2D2B_ENST00000410012.2_Frame_Shift_Del_p.DC212fs	NM_001001732.3	NP_001001732.2	Q6DHV5	C2D2B_HUMAN	coiled-coil and C2 domain containing 2B	212										large_intestine(1)|lung(7)|ovary(1)|urinary_tract(1)	10		Colorectal(252;0.158)		Epithelial(162;7.08e-08)|all cancers(201;2.71e-06)		AAAGTGTAGATTGTTTGTTTGATG	0.363													9	130	---	---	---	---					
INSM2	0	broad.mit.edu	37	14	36003785	36003785	+	Frame_Shift_Del	DEL	C	C	-			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr14:36003785delC	ENST00000307169.3	+	1	538	c.327delC	c.(325-327)agfs	p.S109fs		NM_032594.3	NP_115983.3	Q96T92	INSM2_HUMAN	insulinoma-associated 2	109					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(1)|large_intestine(1)|lung(3)|skin(1)|urinary_tract(1)	10	Breast(36;0.122)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(9;2.16e-07)|Lung(238;2.63e-07)|Epithelial(34;0.00145)|all cancers(34;0.00452)	GBM - Glioblastoma multiforme(112;0.0223)		ccagccccagccccagtccAG	0.781													3	5	---	---	---	---					
RP11-252A24.2	0	broad.mit.edu	37	16	74372915	74372915	+	RNA	DEL	T	T	-	rs67181940		TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr16:74372915delT	ENST00000429810.2	-	0	1404																											ACGTAGtttgttttttttttt	0.438													3	5	---	---	---	---					
RP13-329D4.3	0	broad.mit.edu	37	20	26113543	26113543	+	RNA	DEL	A	A	-			TCGA-G9-6369-01A-21D-1961-08	TCGA-G9-6369-10A-01D-1961-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	954243c2-9440-4e7f-950d-ab48dfe1b570	46642782-ebe5-4fd1-8991-d0ee682f5ab5	g.chr20:26113543delA	ENST00000416563.1	-	0	250																											TCTTTGCCTTAACAACATTAT	0.363													2	4	---	---	---	---					
