Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	filter
MTOR	2475	broad.mit.edu	37	1	11181422	11181422	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr1:11181422C>A	uc001asd.2	-	49	6935	c.6814G>T	c.(6814-6816)GCT>TCT	p.A2272S	MTOR_uc001asc.2_Missense_Mutation_p.A477S	NM_004958	NP_004949	P42345	MTOR_HUMAN	FK506 binding protein 12-rapamycin associated	2272	PI3K/PI4K.				cell growth|cellular response to hypoxia|insulin receptor signaling pathway|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|phosphatidylinositol-mediated signaling|protein autophosphorylation|protein catabolic process|response to amino acid stimulus|response to nutrient|T cell costimulation|TOR signaling cascade	endoplasmic reticulum membrane|Golgi membrane|lysosome|mitochondrial outer membrane|phosphatidylinositol 3-kinase complex|PML body|TORC1 complex|TORC2 complex	ATP binding|phosphoprotein binding|protein serine/threonine kinase activity			central_nervous_system(7)|lung(6)|ovary(6)|skin(3)|kidney(3)|large_intestine(2)|breast(2)	29						TAGTCCGGAGCCATCTGCATC	0.527													14	57	---	---	---	---	PASS
SESN2	83667	broad.mit.edu	37	1	28599167	28599167	+	Missense_Mutation	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr1:28599167C>T	uc001bps.2	+	5	966	c.613C>T	c.(613-615)CAC>TAC	p.H205Y		NM_031459	NP_113647	P58004	SESN2_HUMAN	sestrin 2	205					cell cycle arrest	cytoplasm|nucleus				skin(3)|ovary(2)|pancreas(1)|lung(1)	7		Colorectal(325;3.46e-05)|Lung NSC(340;4.37e-05)|all_lung(284;4.76e-05)|Renal(390;0.00121)|Breast(348;0.00345)|all_neural(195;0.0208)|Myeloproliferative disorder(586;0.0255)|Ovarian(437;0.0261)		OV - Ovarian serous cystadenocarcinoma(117;2.98e-22)|Colorectal(126;3.04e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|KIRC - Kidney renal clear cell carcinoma(1967;0.00279)|STAD - Stomach adenocarcinoma(196;0.00303)|BRCA - Breast invasive adenocarcinoma(304;0.00595)|READ - Rectum adenocarcinoma(331;0.0649)		CACCCACTGCCACTCGCTCTC	0.637													18	61	---	---	---	---	PASS
MACF1	23499	broad.mit.edu	37	1	39905023	39905023	+	Missense_Mutation	SNP	T	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr1:39905023T>C	uc010oiu.1	+	37	13758	c.13627T>C	c.(13627-13629)TTT>CTT	p.F4543L	MACF1_uc010ois.1_Missense_Mutation_p.F4041L	NM_033044	NP_149033	Q9UPN3	MACF1_HUMAN	microfilament and actin filament cross-linker	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					cell cycle arrest|Golgi to plasma membrane protein transport|positive regulation of Wnt receptor signaling pathway|regulation of epithelial cell migration|regulation of focal adhesion assembly|regulation of microtubule-based process|Wnt receptor signaling pathway|wound healing	Golgi apparatus|microtubule|ruffle membrane	actin filament binding|ATPase activity|calcium ion binding|microtubule binding			ovary(8)|breast(3)|central_nervous_system(3)|skin(2)	16	Lung NSC(20;5.57e-06)|Ovarian(52;0.00769)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;7.78e-19)|Epithelial(16;1.73e-17)|all cancers(16;2.49e-16)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			AGAAATCAAATTTCTTGATGT	0.418													15	54	---	---	---	---	PASS
DNAJC6	9829	broad.mit.edu	37	1	65854059	65854059	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr1:65854059G>T	uc001dcd.1	+	9	1147	c.983G>T	c.(982-984)GGA>GTA	p.G328V	DNAJC6_uc001dcc.1_Missense_Mutation_p.G359V|DNAJC6_uc010opc.1_Missense_Mutation_p.G315V|DNAJC6_uc001dce.1_Missense_Mutation_p.G385V	NM_014787	NP_055602	O75061	AUXI_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 6	328	C2 tensin-type.				cellular membrane organization|post-Golgi vesicle-mediated transport	cytosol	heat shock protein binding|protein tyrosine phosphatase activity|SH3 domain binding			large_intestine(1)|lung(1)|ovary(1)	3						TTTCACACTGGATTCATACCA	0.393													35	70	---	---	---	---	PASS
LRRC7	57554	broad.mit.edu	37	1	70446061	70446061	+	Splice_Site	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr1:70446061G>A	uc001dep.2	+	7	628	c.598_splice	c.e7-1	p.P200_splice	LRRC7_uc009wbg.2_Splice_Site	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7							centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						TTCTCTCCCAGCCTGAAGTTC	0.343													37	141	---	---	---	---	PASS
LRRC7	57554	broad.mit.edu	37	1	70451935	70451935	+	Missense_Mutation	SNP	A	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr1:70451935A>T	uc001dep.2	+	8	713	c.683A>T	c.(682-684)AAG>ATG	p.K228M	LRRC7_uc009wbg.2_Translation_Start_Site	NM_020794	NP_065845	Q96NW7	LRRC7_HUMAN	leucine rich repeat containing 7	228	LRR 9.					centrosome|focal adhesion|nucleolus	protein binding			ovary(9)|breast(2)|central_nervous_system(2)|liver(1)	14						TCTATAGGGAAGTTAAAGATG	0.358													6	33	---	---	---	---	PASS
C1orf173	127254	broad.mit.edu	37	1	75038652	75038652	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr1:75038652C>A	uc001dgg.2	-	14	2961	c.2742G>T	c.(2740-2742)GAG>GAT	p.E914D		NM_001002912	NP_001002912	Q5RHP9	CA173_HUMAN	hypothetical protein LOC127254	914	Glu-rich.									ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)	5						CATGAAGATGCTCCAAGTTCA	0.542													40	212	---	---	---	---	PASS
IFI44	10561	broad.mit.edu	37	1	79125075	79125075	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr1:79125075G>T	uc001dip.3	+	6	1043	c.919G>T	c.(919-921)GTG>TTG	p.V307L	IFI44_uc010orr.1_Missense_Mutation_p.V307L|IFI44_uc010ors.1_Missense_Mutation_p.V24L	NM_006417	NP_006408	Q8TCB0	IFI44_HUMAN	interferon-induced, hepatitis C-associated	307					response to virus	cytoplasm				ovary(1)|central_nervous_system(1)	2						AATTCATTGTGTGGCATTTGT	0.378													21	88	---	---	---	---	PASS
ELTD1	64123	broad.mit.edu	37	1	79383532	79383532	+	Nonsense_Mutation	SNP	A	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr1:79383532A>T	uc001diq.3	-	11	1821	c.1665T>A	c.(1663-1665)TAT>TAA	p.Y555*		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	555	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		TTGTGCCATAATATCTGTATC	0.343													29	141	---	---	---	---	PASS
TTLL7	79739	broad.mit.edu	37	1	84399338	84399338	+	Nonsense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr1:84399338C>A	uc001djc.2	-	9	1396	c.1000G>T	c.(1000-1002)GGA>TGA	p.G334*	TTLL7_uc001djb.2_RNA|TTLL7_uc001djd.2_RNA|TTLL7_uc001dje.2_RNA|TTLL7_uc001djf.2_RNA|TTLL7_uc001djg.2_RNA	NM_024686	NP_078962	Q6ZT98	TTLL7_HUMAN	tubulin tyrosine ligase-like family, member 7	334	TTL.				cell differentiation|nervous system development|protein modification process	cilium|dendrite|microtubule basal body|perikaryon	tubulin-tyrosine ligase activity			ovary(1)	1				all cancers(265;0.0126)|Epithelial(280;0.0372)|OV - Ovarian serous cystadenocarcinoma(397;0.16)		ATATCAAATCCCAGGACTTCA	0.413													22	125	---	---	---	---	PASS
COL11A1	1301	broad.mit.edu	37	1	103352377	103352377	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr1:103352377G>T	uc001dul.2	-	63	5162	c.4844C>A	c.(4843-4845)CCT>CAT	p.P1615H	COL11A1_uc001duk.2_Missense_Mutation_p.P811H|COL11A1_uc001dum.2_Missense_Mutation_p.P1627H|COL11A1_uc001dun.2_Missense_Mutation_p.P1576H|COL11A1_uc009weh.2_Missense_Mutation_p.P1499H	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1615	Fibrillar collagen NC1.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TGGGAAGTCAGGATGGCTGAG	0.433													32	138	---	---	---	---	PASS
ANKRD34A	284615	broad.mit.edu	37	1	145474235	145474235	+	Missense_Mutation	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr1:145474235G>A	uc001enq.1	+	4	2200	c.907G>A	c.(907-909)GAG>AAG	p.E303K	NBPF10_uc001emp.3_Intron|LIX1L_uc001enr.2_5'Flank	NM_001039888	NP_001034977	Q69YU3	AN34A_HUMAN	ankyrin repeat domain 34	303	Pro-rich.										0	all_hematologic(18;0.0187)|Acute lymphoblastic leukemia(18;0.0786)					CCCATGGGCGGAGAAAGTGAC	0.632													11	42	---	---	---	---	PASS
LYSMD1	388695	broad.mit.edu	37	1	151134303	151134303	+	Missense_Mutation	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr1:151134303G>A	uc001ewy.2	-	2	1090	c.454C>T	c.(454-456)CTC>TTC	p.L152F	LYSMD1_uc010pcr.1_Missense_Mutation_p.L104F	NM_212551	NP_997716	Q96S90	LYSM1_HUMAN	LysM, putative peptidoglycan-binding, domain	152					cell wall macromolecule catabolic process						0	Lung SC(34;0.00471)|Ovarian(49;0.0147)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			GAGGCAGAGAGGTCATGGATG	0.517													63	148	---	---	---	---	PASS
PSMB4	5692	broad.mit.edu	37	1	151372951	151372951	+	Silent	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr1:151372951C>T	uc001eyc.1	+	3	404	c.381C>T	c.(379-381)AGC>AGT	p.S127S	PSMB4_uc010pda.1_Silent_p.S127S|PSMB4_uc001eyb.1_3'UTR	NM_002796	NP_002787	P28070	PSB4_HUMAN	proteasome beta 4 subunit	127					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex	threonine-type endopeptidase activity			ovary(2)	2	Lung SC(34;0.00471)|Ovarian(49;0.00871)|Hepatocellular(266;0.0997)|all_hematologic(923;0.127)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.112)|LUSC - Lung squamous cell carcinoma(543;0.181)			ATGGACACAGCTATAGTCCTA	0.498													19	207	---	---	---	---	PASS
TCHHL1	126637	broad.mit.edu	37	1	152057612	152057612	+	Missense_Mutation	SNP	A	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr1:152057612A>C	uc001ezo.1	-	3	2611	c.2546T>G	c.(2545-2547)TTT>TGT	p.F849C		NM_001008536	NP_001008536	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	849							calcium ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			GTAGTTGAAAAAGACAGAACA	0.507													48	90	---	---	---	---	PASS
TCHHL1	126637	broad.mit.edu	37	1	152057616	152057616	+	Missense_Mutation	SNP	C	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr1:152057616C>G	uc001ezo.1	-	3	2607	c.2542G>C	c.(2542-2544)GTC>CTC	p.V848L		NM_001008536	NP_001008536	Q5QJ38	TCHL1_HUMAN	trichohyalin-like 1	848							calcium ion binding			ovary(1)|skin(1)	2	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			TTGAAAAAGACAGAACAATCT	0.502													50	89	---	---	---	---	PASS
FLG	2312	broad.mit.edu	37	1	152283855	152283855	+	Silent	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr1:152283855C>T	uc001ezu.1	-	3	3543	c.3507G>A	c.(3505-3507)CCG>CCA	p.P1169P	uc001ezv.2_5'Flank	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1169	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TCCTTGACCCCGGGTGTGCAC	0.597									Ichthyosis				17	796	---	---	---	---	PASS
ATP8B2	57198	broad.mit.edu	37	1	154304496	154304496	+	Missense_Mutation	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr1:154304496G>A	uc001fey.1	+	7	751	c.562G>A	c.(562-564)GAT>AAT	p.D188N	ATP8B2_uc001few.2_Missense_Mutation_p.D169N|ATP8B2_uc001fex.2_Missense_Mutation_p.D202N	NM_001005855	NP_001005855	P98198	AT8B2_HUMAN	ATPase, class I, type 8B, member 2 isoform b	188	Cytoplasmic (Potential).				ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(1)|skin(1)	2	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			AGCAGAACTTGATGGGTAAGT	0.483													50	100	---	---	---	---	PASS
PKLR	5313	broad.mit.edu	37	1	155264485	155264485	+	Silent	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr1:155264485G>A	uc001fkb.3	-	6	792	c.753C>T	c.(751-753)GGC>GGT	p.G251G	RAG1AP1_uc010pey.1_Intron|PKLR_uc001fka.3_Silent_p.G220G	NM_000298	NP_000289	P30613	KPYR_HUMAN	pyruvate kinase, liver and RBC isoform 1	251					endocrine pancreas development|energy reserve metabolic process|glycolysis|positive regulation of cellular metabolic process	cytosol	ATP binding|magnesium ion binding|potassium ion binding|pyruvate kinase activity	p.G251S(2)		skin(4)|ovary(1)	5	all_lung(78;6.99e-23)|Hepatocellular(266;0.0877)|all_hematologic(923;0.145)		Epithelial(20;3.18e-10)|all cancers(21;7.9e-10)|BRCA - Breast invasive adenocarcinoma(34;0.00116)|LUSC - Lung squamous cell carcinoma(543;0.127)		Pyruvic acid(DB00119)	GCAAGTTCACGCCCTTCCGGC	0.672													4	50	---	---	---	---	PASS
FCRL5	83416	broad.mit.edu	37	1	157514826	157514826	+	Silent	SNP	A	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr1:157514826A>G	uc001fqu.2	-	4	512	c.354T>C	c.(352-354)TCT>TCC	p.S118S	FCRL5_uc009wsm.2_Silent_p.S118S|FCRL5_uc010phv.1_Silent_p.S118S|FCRL5_uc010phw.1_Silent_p.S33S|FCRL5_uc001fqv.1_Silent_p.S118S|FCRL5_uc010phx.1_5'UTR	NM_031281	NP_112571	Q96RD9	FCRL5_HUMAN	Fc receptor-like 5	118	Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(2)|central_nervous_system(1)	6	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.231)				TCAGAACCACAGAGTCTCCTT	0.413													50	77	---	---	---	---	PASS
SLAMF9	89886	broad.mit.edu	37	1	159922310	159922310	+	Missense_Mutation	SNP	G	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr1:159922310G>C	uc001fus.2	-	3	523	c.406C>G	c.(406-408)CCC>GCC	p.P136A	SLAMF9_uc009wtd.2_Intron|SLAMF9_uc001fut.2_Intron	NM_033438	NP_254273	Q96A28	SLAF9_HUMAN	SLAM family member 9 isoform 1	136	Ig-like C2-type.|Extracellular (Potential).					integral to membrane				ovary(1)	1	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GTGATCTGGGGCTCTGACAGC	0.517													38	117	---	---	---	---	PASS
FCGR2B	2213	broad.mit.edu	37	1	161647118	161647118	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr1:161647118C>A	uc001gaz.1	+	7	910	c.818C>A	c.(817-819)GCC>GAC	p.A273D	FCGR2B_uc001gay.1_Missense_Mutation_p.A272D|FCGR2B_uc001gba.1_Missense_Mutation_p.A253D|FCGR2B_uc001gbb.1_Missense_Mutation_p.A254D|FCGR2B_uc009wun.1_Missense_Mutation_p.A266D	NM_004001	NP_003992	P31994	FCG2B_HUMAN	Fc fragment of IgG, low affinity IIb, receptor	273	Cytoplasmic (Potential).				immune response|interspecies interaction between organisms|regulation of immune response	integral to membrane|plasma membrane	IgG binding|receptor activity				0	all_cancers(52;4.89e-16)|all_hematologic(112;0.0207)		BRCA - Breast invasive adenocarcinoma(70;0.00376)		Abciximab(DB00054)|Adalimumab(DB00051)|Alefacept(DB00092)|Alemtuzumab(DB00087)|Basiliximab(DB00074)|Bevacizumab(DB00112)|Cetuximab(DB00002)|Daclizumab(DB00111)|Efalizumab(DB00095)|Etanercept(DB00005)|Gemtuzumab ozogamicin(DB00056)|Ibritumomab(DB00078)|Immune globulin(DB00028)|Muromonab(DB00075)|Natalizumab(DB00108)|Palivizumab(DB00110)|Rituximab(DB00073)|Tositumomab(DB00081)|Trastuzumab(DB00072)	TTTCCCACAGCCAATCCCACT	0.532			T	?	ALL								26	70	---	---	---	---	PASS
ALDH9A1	223	broad.mit.edu	37	1	165649797	165649797	+	Missense_Mutation	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr1:165649797G>A	uc001gdh.1	-	5	821	c.716C>T	c.(715-717)ACA>ATA	p.T239I	ALDH9A1_uc010pky.1_Missense_Mutation_p.T145I|ALDH9A1_uc010pkz.1_Missense_Mutation_p.T229I|ALDH9A1_uc010pla.1_Missense_Mutation_p.T145I	NM_000696	NP_000687	P49189	AL9A1_HUMAN	aldehyde dehydrogenase 9A1	215					carnitine biosynthetic process|cellular aldehyde metabolic process|hormone metabolic process|neurotransmitter biosynthetic process	cytosol|plasma membrane	3-chloroallyl aldehyde dehydrogenase activity|4-trimethylammoniobutyraldehyde dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|aminobutyraldehyde dehydrogenase activity				0	all_hematologic(923;0.0773)|Acute lymphoblastic leukemia(8;0.155)				NADH(DB00157)	AAACTGGCCTGTGGCAGCCCC	0.532													83	127	---	---	---	---	PASS
TNN	63923	broad.mit.edu	37	1	175054540	175054540	+	Splice_Site	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr1:175054540G>T	uc001gkl.1	+	6	1348	c.1235_splice	c.e6-1	p.G412_splice	TNN_uc010pmx.1_Splice_Site_p.G412_splice	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor						cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CTTGTTTCCAGGTCTGCACCC	0.597													9	18	---	---	---	---	PASS
RFWD2	64326	broad.mit.edu	37	1	176132955	176132955	+	Missense_Mutation	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr1:176132955C>T	uc001gku.1	-	4	894	c.638G>A	c.(637-639)AGC>AAC	p.S213N	RFWD2_uc001gkv.1_Intron|RFWD2_uc001gkw.1_Intron|RFWD2_uc009wwv.2_5'Flank|RFWD2_uc001gkt.1_Missense_Mutation_p.S72N	NM_022457	NP_071902	Q8NHY2	RFWD2_HUMAN	ring finger and WD repeat domain 2 isoform a	213					DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest	centrosome|cytosol|focal adhesion|nuclear speck	protein binding|ubiquitin-protein ligase activity|zinc ion binding				0						ACATACGGTGCTACTCACTGA	0.274													35	43	---	---	---	---	PASS
PAPPA2	60676	broad.mit.edu	37	1	176564618	176564618	+	Silent	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr1:176564618G>A	uc001gkz.2	+	3	3042	c.1878G>A	c.(1876-1878)GGG>GGA	p.G626G	PAPPA2_uc001gky.1_Silent_p.G626G|PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	626	Metalloprotease.				cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GCAGGGATGGGCTCTGTCACG	0.602													12	83	---	---	---	---	PASS
FAM5C	339479	broad.mit.edu	37	1	190423895	190423895	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr1:190423895G>T	uc001gse.1	-	2	358	c.126C>A	c.(124-126)AGC>AGA	p.S42R	FAM5C_uc010pot.1_Missense_Mutation_p.A4D	NM_199051	NP_950252	Q76B58	FAM5C_HUMAN	family with sequence similarity 5, member C	42						extracellular region				lung(2)|ovary(1)|kidney(1)|skin(1)	5	Prostate(682;0.198)					AGTCGAAGGGGCTTGTGGCAT	0.502													25	49	---	---	---	---	PASS
RGS18	64407	broad.mit.edu	37	1	192150519	192150519	+	Silent	SNP	A	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr1:192150519A>T	uc001gsg.2	+	4	557	c.381A>T	c.(379-381)GGA>GGT	p.G127G		NM_130782	NP_570138	Q9NS28	RGS18_HUMAN	regulator of G-protein signalling 18	127	RGS.				negative regulation of signal transduction	cytoplasm|plasma membrane	GTPase activator activity|signal transducer activity			ovary(3)	3						AAAGCAAGGGACCTCAACAAA	0.328													4	98	---	---	---	---	PASS
USH2A	7399	broad.mit.edu	37	1	216260067	216260067	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr1:216260067C>A	uc001hku.1	-	24	5368	c.4981G>T	c.(4981-4983)GAT>TAT	p.D1661Y		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1661	Laminin G-like 1.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TCACCAGGATCCTTCCTGAGG	0.383										HNSCC(13;0.011)			33	58	---	---	---	---	PASS
ACTN2	88	broad.mit.edu	37	1	236883405	236883405	+	Missense_Mutation	SNP	A	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr1:236883405A>C	uc001hyf.2	+	4	566	c.362A>C	c.(361-363)GAA>GCA	p.E121A	ACTN2_uc001hyg.2_5'UTR|ACTN2_uc009xgi.1_Missense_Mutation_p.E121A	NM_001103	NP_001094	P35609	ACTN2_HUMAN	actinin, alpha 2	121	CH 1.|Actin-binding.				focal adhesion assembly|microspike assembly|muscle filament sliding|platelet activation|platelet degranulation|protein homotetramerization|regulation of apoptosis|synaptic transmission	actin filament|cytosol|dendritic spine|extracellular region|filopodium|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|Z disc	actin binding|calcium ion binding|FATZ 1 binding|identical protein binding|integrin binding|protein dimerization activity|structural constituent of muscle|titin binding|titin Z domain binding|ZASP binding			ovary(4)|skin(1)	5	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;0.00661)|Acute lymphoblastic leukemia(190;0.109)|Prostate(94;0.174)	OV - Ovarian serous cystadenocarcinoma(106;0.00168)			TTACCTGCAGAAATTGTTGAT	0.353													34	74	---	---	---	---	PASS
RYR2	6262	broad.mit.edu	37	1	237893559	237893559	+	Splice_Site	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr1:237893559G>T	uc001hyl.1	+	77	10959	c.10839_splice	c.e77-1	p.R3613_splice	RYR2_uc010pya.1_Splice_Site_p.R9_splice	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor						cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TTACCTTTCAGGCATCGGGCT	0.338													30	33	---	---	---	---	PASS
RYR2	6262	broad.mit.edu	37	1	237893560	237893560	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr1:237893560G>T	uc001hyl.1	+	77	10959	c.10839G>T	c.(10837-10839)AGG>AGT	p.R3613S	RYR2_uc010pya.1_Missense_Mutation_p.R9S	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3613					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			TACCTTTCAGGCATCGGGCTG	0.338													29	34	---	---	---	---	PASS
ZP4	57829	broad.mit.edu	37	1	238048518	238048518	+	Missense_Mutation	SNP	A	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr1:238048518A>C	uc001hym.2	-	9	1258	c.1258T>G	c.(1258-1260)TTC>GTC	p.F420V	LOC100130331_uc010pyc.1_Intron	NM_021186	NP_067009	Q12836	ZP4_HUMAN	zona pellucida glycoprotein 4 preproprotein	420	ZP.|Extracellular (Potential).				acrosomal vesicle exocytosis|negative regulation of binding of sperm to zona pellucida|positive regulation of acrosome reaction|positive regulation of humoral immune response|positive regulation of protein kinase activity|positive regulation of T cell proliferation|protein kinase A signaling cascade|protein kinase C signaling cascade	integral to membrane|intracellular|plasma membrane|proteinaceous extracellular matrix	acrosin binding|receptor activity			ovary(2)|skin(1)	3	Ovarian(103;0.103)	all_cancers(173;0.00175)|all_epithelial(177;0.162)|all_neural(198;0.164)|Melanoma(53;0.211)|Prostate(94;0.214)	OV - Ovarian serous cystadenocarcinoma(106;0.00989)			CTGAAGGTGAAGATGCTGAAG	0.547													27	86	---	---	---	---	PASS
CAD	790	broad.mit.edu	37	2	27448094	27448094	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr2:27448094G>T	uc002rji.2	+	11	1765	c.1603G>T	c.(1603-1605)GCA>TCA	p.A535S	CAD_uc010eyw.2_Missense_Mutation_p.A535S	NM_004341	NP_004332	P27708	PYR1_HUMAN	carbamoylphosphate synthetase 2/aspartate	535	CPSase (Carbamoyl-phosphate synthase).|CPSase A.|ATP-grasp 1.			A -> G (in Ref. 1; BAA11423).	'de novo' pyrimidine base biosynthetic process|drug metabolic process|glutamine metabolic process|peptidyl-threonine phosphorylation|protein autophosphorylation|pyrimidine nucleoside biosynthetic process|pyrimidine nucleotide biosynthetic process	cytosol|neuronal cell body|nuclear matrix|terminal button	aspartate binding|aspartate carbamoyltransferase activity|ATP binding|carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity|dihydroorotase activity|enzyme binding|identical protein binding|metal ion binding|protein kinase activity			ovary(4)|large_intestine(2)|kidney(2)|lung(1)|pancreas(1)	10	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				L-Aspartic Acid(DB00128)|L-Glutamine(DB00130)	GAGCGAGGCAGCAAATTCTCT	0.463													17	24	---	---	---	---	PASS
BRE	9577	broad.mit.edu	37	2	28521252	28521252	+	Nonsense_Mutation	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr2:28521252C>T	uc002rlr.2	+	12	1300	c.982C>T	c.(982-984)CAG>TAG	p.Q328*	BRE_uc002rlp.1_Nonsense_Mutation_p.Q328*|BRE_uc002rlq.2_Nonsense_Mutation_p.Q328*|BRE_uc002rls.2_Nonsense_Mutation_p.Q328*|BRE_uc002rlt.2_Nonsense_Mutation_p.Q328*|BRE_uc002rlu.2_Nonsense_Mutation_p.Q328*|BRE_uc002rlv.2_Nonsense_Mutation_p.Q190*|BRE_uc002rlx.2_RNA	NM_199194	NP_954664	Q9NXR7	BRE_HUMAN	brain and reproductive organ-expressed (TNFRSF1A	328	UEV-like 2.				apoptosis|chromatin modification|double-strand break repair|G2/M transition DNA damage checkpoint|positive regulation of anti-apoptosis|positive regulation of DNA repair|response to ionizing radiation|signal transduction	BRCA1-A complex|BRISC complex|cytoplasm|nuclear ubiquitin ligase complex	peroxisome targeting sequence binding|polyubiquitin binding|tumor necrosis factor receptor binding			lung(1)|kidney(1)|skin(1)	3	Acute lymphoblastic leukemia(172;0.155)					TCTCACATTTCAGTCCGTTTA	0.428													9	288	---	---	---	---	PASS
BIRC6	57448	broad.mit.edu	37	2	32664696	32664696	+	Missense_Mutation	SNP	A	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr2:32664696A>T	uc010ezu.2	+	16	3886	c.3752A>T	c.(3751-3753)CAC>CTC	p.H1251L		NM_016252	NP_057336	Q9NR09	BIRC6_HUMAN	baculoviral IAP repeat-containing 6	1251					anti-apoptosis|apoptosis	intracellular	acid-amino acid ligase activity|cysteine-type endopeptidase inhibitor activity|protein binding			ovary(5)|skin(4)|lung(2)|central_nervous_system(1)|breast(1)|pancreas(1)	14	Acute lymphoblastic leukemia(172;0.155)					TCCCTAAAACACCAGAGTAAC	0.388													11	52	---	---	---	---	PASS
FSHR	2492	broad.mit.edu	37	2	49190433	49190433	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr2:49190433G>T	uc002rww.2	-	10	1601	c.1527C>A	c.(1525-1527)AGC>AGA	p.S509R	FSHR_uc002rwx.2_Missense_Mutation_p.S447R|FSHR_uc010fbn.2_Missense_Mutation_p.S483R	NM_000145	NP_000136	P23945	FSHR_HUMAN	follicle stimulating hormone receptor isoform 1	509	Extracellular (Potential).				female gamete generation|male gonad development|spermatogenesis	integral to membrane|plasma membrane	follicle-stimulating hormone receptor activity|protein binding			ovary(4)|lung(2)|central_nervous_system(1)|skin(1)	8		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.181)	Lung(47;0.101)|LUSC - Lung squamous cell carcinoma(58;0.151)		Choriogonadotropin alfa(DB00097)|Follitropin beta(DB00066)|Menotropins(DB00032)|Urofollitropin(DB00094)	TCATGTAGCTGCTGATGCCAA	0.532									Gonadal_Dysgenesis_46_XX				6	24	---	---	---	---	PASS
CHAC2	494143	broad.mit.edu	37	2	54001636	54001636	+	Missense_Mutation	SNP	G	C	C	rs74780760	byFrequency	TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr2:54001636G>C	uc002rxk.1	+	3	624	c.529G>C	c.(529-531)GGG>CGG	p.G177R	ASB3_uc002rxg.1_Intron|ASB3_uc002rxh.1_Intron|ASB3_uc002rxi.3_Intron|ASB3_uc010yoo.1_Intron	NM_001008708	NP_001008708	Q8WUX2	CHAC2_HUMAN	ChaC, cation transport regulator-like 2	177											0			Lung(47;0.125)|LUSC - Lung squamous cell carcinoma(58;0.181)			ACGTTTAGAAGGGAAACAGAA	0.323													24	45	---	---	---	---	PASS
CLEC4F	165530	broad.mit.edu	37	2	71046962	71046962	+	Silent	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr2:71046962G>A	uc002shf.2	-	2	200	c.123C>T	c.(121-123)ACC>ACT	p.T41T	CLEC4F_uc010yqv.1_Silent_p.T41T	NM_173535	NP_775806	Q8N1N0	CLC4F_HUMAN	C-type lectin, superfamily member 13	41	Helical; Signal-anchor for type II membrane protein; (Potential).				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(5)	5						TAAATGCCGGGGTAGCCTGAA	0.552													8	49	---	---	---	---	PASS
LRRTM4	80059	broad.mit.edu	37	2	77745534	77745534	+	Silent	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr2:77745534G>A	uc002snr.2	-	3	1876	c.1461C>T	c.(1459-1461)GAC>GAT	p.D487D	LRRTM4_uc002snq.2_Silent_p.D487D|LRRTM4_uc002sns.2_Silent_p.D487D|LRRTM4_uc002snt.2_Silent_p.D488D	NM_001134745	NP_001128217	Q86VH4	LRRT4_HUMAN	leucine rich repeat transmembrane neuronal 4	487	Cytoplasmic (Potential).					integral to membrane				pancreas(3)|ovary(1)	4				Colorectal(11;0.059)		TAGGCTTGTAGTCCACATAAT	0.458													11	39	---	---	---	---	PASS
REG3A	5068	broad.mit.edu	37	2	79385824	79385824	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr2:79385824G>T	uc002sod.1	-	2	403	c.148C>A	c.(148-150)CAC>AAC	p.H50N	REG3A_uc002soe.1_Missense_Mutation_p.H50N|REG3A_uc002sof.1_Missense_Mutation_p.H50N	NM_138938	NP_620355	Q06141	REG3A_HUMAN	pancreatitis-associated protein precursor	50	C-type lectin.				acute-phase response|cell proliferation|heterophilic cell-cell adhesion|multicellular organismal development	cytoplasm|extracellular space|soluble fraction	sugar binding			skin(1)	1						GCATAGCAGTGGGAGCCATAG	0.567													23	43	---	---	---	---	PASS
Unknown	0	broad.mit.edu	37	2	89384752	89384752	+	RNA	SNP	G	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr2:89384752G>C	uc010ytr.1	-	50		c.5388C>G			uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																		AGTGAACTCTGTCCCAGACCC	0.522													11	79	---	---	---	---	PASS
FAHD2B	151313	broad.mit.edu	37	2	97749943	97749943	+	Missense_Mutation	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr2:97749943C>T	uc002sxm.2	-	6	908	c.757G>A	c.(757-759)GTA>ATA	p.V253I		NM_199336	NP_955368	Q6P2I3	FAH2B_HUMAN	fumarylacetoacetate hydrolase domain containing	253							hydrolase activity|metal ion binding				0						GTCTTGAATACCATCTGGTTG	0.542													25	104	---	---	---	---	PASS
ST6GAL2	84620	broad.mit.edu	37	2	107423321	107423321	+	Missense_Mutation	SNP	T	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr2:107423321T>C	uc002tdq.2	-	6	1522	c.1403A>G	c.(1402-1404)TAC>TGC	p.Y468C	ST6GAL2_uc002tdr.2_Missense_Mutation_p.Y468C	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	468	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						CAGCTCGTGGTAGTGGCACAG	0.562													12	48	---	---	---	---	PASS
SLC35F5	80255	broad.mit.edu	37	2	114503904	114503904	+	Missense_Mutation	SNP	C	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr2:114503904C>G	uc002tku.1	-	5	854	c.430G>C	c.(430-432)GAA>CAA	p.E144Q	SLC35F5_uc002tkt.2_RNA|SLC35F5_uc002tkv.2_Missense_Mutation_p.E138Q|SLC35F5_uc002tkw.2_Missense_Mutation_p.E144Q	NM_025181	NP_079457	Q8WV83	S35F5_HUMAN	solute carrier family 35, member F5	144					transport	integral to membrane					0						AAGTAACCTTCAGCATCTGCA	0.368													39	51	---	---	---	---	PASS
FAM123C	205147	broad.mit.edu	37	2	131520539	131520539	+	Silent	SNP	C	A	A	rs140458255		TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr2:131520539C>A	uc002trw.2	+	2	1084	c.894C>A	c.(892-894)CCC>CCA	p.P298P	FAM123C_uc010fmv.2_Silent_p.P298P|FAM123C_uc010fms.1_Silent_p.P298P|FAM123C_uc010fmt.1_Silent_p.P298P|FAM123C_uc010fmu.1_Silent_p.P298P	NM_152698	NP_689911	Q8N944	F123C_HUMAN	hypothetical protein LOC205147	298										pancreas(2)|ovary(1)	3	Colorectal(110;0.1)			BRCA - Breast invasive adenocarcinoma(221;0.13)		TGGCCTCGCCCGCCCAGAATG	0.657													21	31	---	---	---	---	PASS
POTEE	445582	broad.mit.edu	37	2	132021476	132021476	+	Silent	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr2:132021476C>T	uc002tsn.2	+	15	2500	c.2448C>T	c.(2446-2448)CGC>CGT	p.R816R	PLEKHB2_uc002tsh.2_Intron|POTEE_uc002tsk.2_Silent_p.R416R|POTEE_uc002tsl.2_Silent_p.R398R|POTEE_uc010fmy.1_Silent_p.R280R	NM_001083538	NP_001077007	Q6S8J3	POTEE_HUMAN	protein expressed in prostate, ovary, testis,	816	Actin-like.						ATP binding				0						AGGCCAACCGCGAGAAGATGA	0.607													25	191	---	---	---	---	PASS
LYPD1	116372	broad.mit.edu	37	2	133427492	133427492	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr2:133427492C>A	uc002ttn.2	-	1	990	c.14G>T	c.(13-15)GGC>GTC	p.G5V	LYPD1_uc002ttm.3_Missense_Mutation_p.S21I|LYPD1_uc002tto.2_Intron	NM_144586	NP_653187	Q8N2G4	LYPD1_HUMAN	LY6/PLAUR domain containing 1 isoform a	5						anchored to membrane|plasma membrane					0						TGCCGCGATGCCTAGGACCCA	0.657													3	33	---	---	---	---	PASS
LRP1B	53353	broad.mit.edu	37	2	141707967	141707967	+	Silent	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr2:141707967G>A	uc002tvj.1	-	20	3945	c.2973C>T	c.(2971-2973)GAC>GAT	p.D991D	LRP1B_uc010fnl.1_Silent_p.D173D	NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	991	Extracellular (Potential).|LDL-receptor class A 6.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		CCCCACAGTCGTCATCTGGAA	0.438										TSP Lung(27;0.18)			15	36	---	---	---	---	PASS
NEB	4703	broad.mit.edu	37	2	152520262	152520262	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr2:152520262C>A	uc010fnx.2	-	45	5754	c.5563G>T	c.(5563-5565)GAC>TAC	p.D1855Y		NM_004543	NP_004534	P20929	NEBU_HUMAN	nebulin isoform 3	1855	Nebulin 48.				muscle filament sliding|muscle organ development|regulation of actin filament length|somatic muscle development	actin cytoskeleton|cytosol|Z disc	actin binding|structural constituent of muscle			ovary(8)|large_intestine(5)|breast(3)|central_nervous_system(2)|skin(1)|pancreas(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.219)		TATTCCCGGTCTGACTGCATC	0.532													27	51	---	---	---	---	PASS
ACVR1C	130399	broad.mit.edu	37	2	158401074	158401074	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr2:158401074C>A	uc002tzk.3	-	5	1069	c.826G>T	c.(826-828)GGC>TGC	p.G276C	ACVR1C_uc002tzl.3_Missense_Mutation_p.G196C|ACVR1C_uc010fof.2_Missense_Mutation_p.G119C|ACVR1C_uc010foe.2_Missense_Mutation_p.G226C	NM_145259	NP_660302	Q8NER5	ACV1C_HUMAN	activin A receptor, type IC isoform 1	276	Protein kinase.|Cytoplasmic (Potential).				apoptosis|cell differentiation|regulation of apoptosis	activin receptor complex	activin receptor activity, type I|ATP binding|transforming growth factor beta receptor activity			lung(3)|ovary(2)|skin(2)	7						TATAAGGAGCCCTGTTCATGA	0.378													30	48	---	---	---	---	PASS
SCN3A	6328	broad.mit.edu	37	2	165970326	165970326	+	Silent	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr2:165970326C>T	uc002ucx.2	-	20	4161	c.3669G>A	c.(3667-3669)TTG>TTA	p.L1223L	SCN3A_uc002ucy.2_Silent_p.L1174L|SCN3A_uc002ucz.2_Silent_p.L1174L|SCN3A_uc002uda.1_Silent_p.L1043L|SCN3A_uc002udb.1_Silent_p.L1043L	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	1223	Helical; Name=S1 of repeat III; (Potential).					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	TTTCACTTACCAATGCACCAC	0.378													13	77	---	---	---	---	PASS
SCN1A	6323	broad.mit.edu	37	2	166847771	166847771	+	Missense_Mutation	SNP	T	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr2:166847771T>G	uc010zcz.1	-	26	5999	c.5981A>C	c.(5980-5982)AAA>ACA	p.K1994T		NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	2005						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	CCCTTTGGCTTTTTCATCTTT	0.378													6	35	---	---	---	---	PASS
SCN1A	6323	broad.mit.edu	37	2	166847856	166847856	+	Missense_Mutation	SNP	T	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr2:166847856T>C	uc010zcz.1	-	26	5914	c.5896A>G	c.(5896-5898)ATG>GTG	p.M1966V		NM_006920	NP_008851	P35498	SCN1A_HUMAN	sodium channel, voltage-gated, type I, alpha	1977						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|skin(6)|large_intestine(1)	13					Lamotrigine(DB00555)|Levetiracetam(DB01202)|Phenacemide(DB01121)|Phenytoin(DB00252)|Topiramate(DB00273)|Zonisamide(DB00909)	GCAGTGGACATGGTCAGATCA	0.368													15	67	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179393123	179393123	+	Missense_Mutation	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr2:179393123C>T	uc010zfg.1	-	310	99775	c.99551G>A	c.(99550-99552)CGC>CAC	p.R33184H	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.R26879H|TTN_uc010zfi.1_Missense_Mutation_p.R26812H|TTN_uc010zfj.1_Missense_Mutation_p.R26687H|TTN_uc002umq.2_Missense_Mutation_p.R201H	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	34111							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ATTTCTGGAGCGGCTTATGCT	0.378													35	50	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179473493	179473493	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr2:179473493G>T	uc010zfg.1	-	223	44765	c.44541C>A	c.(44539-44541)GAC>GAA	p.D14847E	uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.D8542E|TTN_uc010zfi.1_Missense_Mutation_p.D8475E|TTN_uc010zfj.1_Missense_Mutation_p.D8350E	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	15774							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCCATTCTGAGTCGGGTTTTG	0.393													14	79	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179613239	179613239	+	Missense_Mutation	SNP	G	T	T	rs139103966		TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr2:179613239G>T	uc002unb.2	-	46	14112	c.13888C>A	c.(13888-13890)CTG>ATG	p.L4630M	TTN_uc010zfg.1_Intron|TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Intron	NM_133379	NP_596870	Q8WZ42	TITIN_HUMAN	titin isoform novex-3	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGGAACTCCAGAGCTGGATCT	0.373													61	110	---	---	---	---	PASS
TTN	7273	broad.mit.edu	37	2	179637971	179637971	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr2:179637971G>T	uc010zfg.1	-	33	7944	c.7720C>A	c.(7720-7722)CCC>ACC	p.P2574T	TTN_uc010zfh.1_Missense_Mutation_p.P2528T|TTN_uc010zfi.1_Missense_Mutation_p.P2528T|TTN_uc010zfj.1_Missense_Mutation_p.P2528T|TTN_uc002unb.2_Missense_Mutation_p.P2574T	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	2574							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TTAGAACTGGGCTTGATTTCC	0.358													7	34	---	---	---	---	PASS
NEUROD1	4760	broad.mit.edu	37	2	182543312	182543312	+	Silent	SNP	A	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr2:182543312A>T	uc002uof.2	-	2	512	c.276T>A	c.(274-276)ACT>ACA	p.T92T	CERKL_uc002uod.1_Intron	NM_002500	NP_002491	Q13562	NDF1_HUMAN	neurogenic differentiation 1	92	Nuclear localization signal (Potential).				amacrine cell differentiation|cerebellum development|dentate gyrus development|embryonic organ morphogenesis|enteroendocrine cell differentiation|glucose homeostasis|inner ear development|insulin secretion|negative regulation of apoptosis|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of neuron differentiation|positive regulation of sequence-specific DNA binding transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|regulation of cell cycle arrest|regulation of intestinal epithelial structure maintenance|response to glucose stimulus	cytoplasm|nucleus	chromatin binding|E-box binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.088)			GGCGAGCCTTAGTCATCTTCT	0.418													13	63	---	---	---	---	PASS
CCDC150	284992	broad.mit.edu	37	2	197577399	197577399	+	Splice_Site	SNP	A	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr2:197577399A>T	uc002utp.1	+	17	1939	c.1804_splice	c.e17-2	p.A602_splice	CCDC150_uc010zgs.1_Intron|CCDC150_uc010zgt.1_Intron	NM_001080539	NP_001074008	Q8NCX0	CC150_HUMAN	coiled-coil domain containing 150												0						TTTGAATTAAAGGCAAACTCA	0.388													8	13	---	---	---	---	PASS
ZDBF2	57683	broad.mit.edu	37	2	207171597	207171597	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr2:207171597G>T	uc002vbp.2	+	5	2595	c.2345G>T	c.(2344-2346)AGC>ATC	p.S782I		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	782							nucleic acid binding|zinc ion binding			ovary(3)	3						GAAGATGAGAGCTGTGAGTCA	0.408													55	106	---	---	---	---	PASS
SPEG	10290	broad.mit.edu	37	2	220332025	220332025	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr2:220332025G>T	uc010fwg.2	+	10	3011	c.3011G>T	c.(3010-3012)CGT>CTT	p.R1004L		NM_005876	NP_005867	Q15772	SPEG_HUMAN	SPEG complex locus	1004	Ig-like 4.				muscle organ development|negative regulation of cell proliferation	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(9)|ovary(4)|central_nervous_system(1)	14		Renal(207;0.0183)		Epithelial(149;4.5e-10)|all cancers(144;7.93e-08)|Lung(261;0.00639)|LUSC - Lung squamous cell carcinoma(224;0.00829)|READ - Rectum adenocarcinoma(5;0.163)		TGGCTGTGCCGTGGCCGCCTG	0.627													18	90	---	---	---	---	PASS
SH3BP4	23677	broad.mit.edu	37	2	235950095	235950095	+	Missense_Mutation	SNP	G	T	T	rs138703238		TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr2:235950095G>T	uc002vvp.2	+	4	1075	c.682G>T	c.(682-684)GCA>TCA	p.A228S	SH3BP4_uc010fym.2_Missense_Mutation_p.A228S|SH3BP4_uc002vvq.2_Missense_Mutation_p.A228S	NM_014521	NP_055336	Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	228					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			skin(3)|ovary(1)	4		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		CGGACTCCACGCAGAGCCGCC	0.572													31	131	---	---	---	---	PASS
ESPNL	339768	broad.mit.edu	37	2	239013419	239013419	+	Missense_Mutation	SNP	T	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr2:239013419T>C	uc002vxq.3	+	3	718	c.608T>C	c.(607-609)CTC>CCC	p.L203P		NM_194312	NP_919288	Q6ZVH7	ESPNL_HUMAN	espin-like	203										pancreas(1)	1		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_hematologic(139;0.158)|all_lung(227;0.198)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;4.71e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.02e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.63e-08)|BRCA - Breast invasive adenocarcinoma(100;0.000109)|Lung(119;0.0108)|LUSC - Lung squamous cell carcinoma(224;0.0253)		CTTCGTGCTCTCGATGGCATG	0.672													7	7	---	---	---	---	PASS
COLQ	8292	broad.mit.edu	37	3	15499735	15499735	+	Silent	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr3:15499735G>A	uc003bzx.2	-	13	1038	c.912C>T	c.(910-912)TAC>TAT	p.Y304Y	COLQ_uc003bzv.2_Silent_p.Y294Y|COLQ_uc003bzz.2_Silent_p.Y295Y|COLQ_uc010heo.2_Silent_p.Y270Y|COLQ_uc003cac.1_RNA|COLQ_uc003cae.1_Silent_p.Y163Y|COLQ_uc003cad.1_RNA	NM_005677	NP_005668	Q9Y215	COLQ_HUMAN	acetylcholinesterase collagen-like tail subunit	304					acetylcholine catabolic process in synaptic cleft|asymmetric protein localization	basal lamina|cell junction|collagen|extracellular space|synaptic cleft					0						CAGATTCCCCGTAGGAAGGGT	0.527													38	85	---	---	---	---	PASS
KBTBD5	131377	broad.mit.edu	37	3	42728190	42728190	+	Silent	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr3:42728190G>A	uc003clv.1	+	1	1180	c.1080G>A	c.(1078-1080)CAG>CAA	p.Q360Q		NM_152393	NP_689606	Q2TBA0	KBTB5_HUMAN	kelch repeat and BTB (POZ) domain containing 5	360	Kelch 1.									ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.214)		AGGAGAACCAGGTCTTCGTGG	0.592													19	27	---	---	---	---	PASS
VPRBP	9730	broad.mit.edu	37	3	51475085	51475085	+	Silent	SNP	T	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr3:51475085T>C	uc003dbe.1	-	9	1197	c.1029A>G	c.(1027-1029)CTA>CTG	p.L343L		NM_014703	NP_055518	Q9Y4B6	VPRBP_HUMAN	HIV-1 Vpr binding protein	343					interspecies interaction between organisms	cytoplasm|nucleus	protein binding			ovary(1)|skin(1)	2				BRCA - Breast invasive adenocarcinoma(193;0.000272)|Kidney(197;0.000729)|KIRC - Kidney renal clear cell carcinoma(197;0.000875)		ATATGGGAAGTAGCTGAAATG	0.378													9	6	---	---	---	---	PASS
CADPS	8618	broad.mit.edu	37	3	62636531	62636531	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr3:62636531G>T	uc003dll.2	-	5	1554	c.1194C>A	c.(1192-1194)TTC>TTA	p.F398L	CADPS_uc003dlm.2_Missense_Mutation_p.F398L|CADPS_uc003dln.2_Missense_Mutation_p.F398L	NM_003716	NP_003707	Q9ULU8	CAPS1_HUMAN	Ca2+-dependent secretion activator isoform 1	398					exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|cytosol|synapse	lipid binding|metal ion binding			central_nervous_system(2)|ovary(1)	3		Lung SC(41;0.0452)		BRCA - Breast invasive adenocarcinoma(55;5.98e-05)|KIRC - Kidney renal clear cell carcinoma(15;0.0246)|Kidney(15;0.0334)		CCTCCAATGAGAAAGACAGCA	0.483													15	52	---	---	---	---	PASS
RYBP	23429	broad.mit.edu	37	3	72427648	72427648	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr3:72427648C>A	uc003dpe.2	-	4	662	c.545G>T	c.(544-546)GGG>GTG	p.G182V		NM_012234	NP_036366	Q8N488	RYBP_HUMAN	RING1 and YY1 binding protein	192	Interaction with E4TF1B.|Ser-rich.				apoptosis|histone H2A monoubiquitination|multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|nucleoplasm	DNA binding|protein binding|transcription corepressor activity|zinc ion binding				0		Prostate(10;0.00174)|Lung NSC(201;0.0659)|Myeloproliferative disorder(1037;0.204)		BRCA - Breast invasive adenocarcinoma(55;0.000197)|Epithelial(33;0.00068)|LUSC - Lung squamous cell carcinoma(21;0.00228)|Lung(16;0.00677)|KIRC - Kidney renal clear cell carcinoma(39;0.198)|Kidney(39;0.232)		CTGTTCTGACCCTGCACTGGA	0.542													19	9	---	---	---	---	PASS
ROBO1	6091	broad.mit.edu	37	3	78987941	78987941	+	Missense_Mutation	SNP	T	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr3:78987941T>G	uc003dqe.2	-	4	517	c.309A>C	c.(307-309)AAA>AAC	p.K103N	ROBO1_uc003dqb.2_Missense_Mutation_p.K64N|ROBO1_uc003dqc.2_Missense_Mutation_p.K64N|ROBO1_uc003dqd.2_Missense_Mutation_p.K64N	NM_002941	NP_002932	Q9Y6N7	ROBO1_HUMAN	roundabout 1 isoform a	103	Extracellular (Potential).|Ig-like C2-type 1.				activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			large_intestine(2)	2		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		TCTCTCCCCCTTTGTACCATT	0.478													12	55	---	---	---	---	PASS
CASR	846	broad.mit.edu	37	3	122002609	122002609	+	Missense_Mutation	SNP	T	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr3:122002609T>C	uc003eev.3	+	7	2180	c.1808T>C	c.(1807-1809)ATC>ACC	p.I603T	CASR_uc003eew.3_Missense_Mutation_p.I613T	NM_000388	NP_000379	P41180	CASR_HUMAN	calcium-sensing receptor precursor	603	Extracellular (Potential).				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			ovary(4)|skin(2)|upper_aerodigestive_tract(1)	7				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	GCCAAGGAGATCGAGTTTCTG	0.522													25	53	---	---	---	---	PASS
RUVBL1	8607	broad.mit.edu	37	3	127842517	127842517	+	Silent	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr3:127842517G>A	uc003ekh.2	-	1	155	c.51C>T	c.(49-51)TCC>TCT	p.S17S	RUVBL1_uc003ekf.2_Intron|RUVBL1_uc010hss.2_Silent_p.S17S	NM_003707	NP_003698	Q9Y265	RUVB1_HUMAN	RuvB-like 1	17					cell division|CenH3-containing nucleosome assembly at centromere|DNA recombination|DNA repair|histone H2A acetylation|histone H4 acetylation|mitosis|regulation of growth|regulation of transcription from RNA polymerase II promoter|spermatogenesis|transcription, DNA-dependent	Golgi apparatus|Ino80 complex|membrane|microtubule organizing center|MLL1 complex|NuA4 histone acetyltransferase complex|nuclear matrix	ATP binding|DNA helicase activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.181)		CGTGGCTGTGGGAGGCGATGC	0.622													4	85	---	---	---	---	PASS
CPNE4	131034	broad.mit.edu	37	3	131283166	131283166	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr3:131283166C>A	uc003eok.2	-	11	1390	c.955G>T	c.(955-957)GGG>TGG	p.G319W	CPNE4_uc011blq.1_Missense_Mutation_p.G337W|CPNE4_uc003eol.2_Missense_Mutation_p.G337W|CPNE4_uc003eom.2_Missense_Mutation_p.G319W	NM_130808	NP_570720	Q96A23	CPNE4_HUMAN	copine IV	319	VWFA.									upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	3						CTGGGGTCCCCGTTTGAGGCA	0.428													27	62	---	---	---	---	PASS
LRRIQ4	344657	broad.mit.edu	37	3	169539929	169539929	+	Missense_Mutation	SNP	A	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr3:169539929A>G	uc003fgb.2	+	1	220	c.220A>G	c.(220-222)AGG>GGG	p.R74G		NM_001080460	NP_001073929	A6NIV6	LRIQ4_HUMAN	leucine-rich repeats and IQ motif containing 4	74	LRR 3.										0						AAAGAACATCAGGGTCCTCTA	0.498													54	103	---	---	---	---	PASS
SPATA16	83893	broad.mit.edu	37	3	172674469	172674469	+	Missense_Mutation	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr3:172674469G>A	uc003fin.3	-	6	1237	c.1079C>T	c.(1078-1080)ACA>ATA	p.T360I		NM_031955	NP_114161	Q9BXB7	SPT16_HUMAN	spermatogenesis associated 16	360					cell differentiation|multicellular organismal development|spermatogenesis	Golgi apparatus	binding			ovary(2)|skin(1)	3	Ovarian(172;0.00319)|Breast(254;0.197)		LUSC - Lung squamous cell carcinoma(14;1.48e-14)|Lung(28;6.63e-14)			AATCTTACCTGTGTACATATA	0.294													13	48	---	---	---	---	PASS
ATP11B	23200	broad.mit.edu	37	3	182615170	182615170	+	Missense_Mutation	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr3:182615170C>T	uc003flb.2	+	27	3385	c.3128C>T	c.(3127-3129)TCC>TTC	p.S1043F	ATP11B_uc003flc.2_Missense_Mutation_p.S627F|ATP11B_uc010hxf.1_Missense_Mutation_p.S205F|ATP11B_uc010hxg.2_RNA|ATP11B_uc010hxh.1_5'Flank	NM_014616	NP_055431	Q9Y2G3	AT11B_HUMAN	ATPase, class VI, type 11B	1043	Helical; (Potential).				aminophospholipid transport|ATP biosynthetic process	integral to membrane|nuclear inner membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3	all_cancers(143;9.04e-15)|Ovarian(172;0.0355)		all cancers(12;1.2e-42)|Epithelial(37;2.77e-36)|LUSC - Lung squamous cell carcinoma(7;7.58e-24)|Lung(8;4.66e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.35e-20)			TTTGTATTTTCCTTGTTTTAT	0.294													31	167	---	---	---	---	PASS
CLCN2	1181	broad.mit.edu	37	3	184074816	184074816	+	Silent	SNP	C	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr3:184074816C>G	uc003foi.2	-	10	1174	c.1050G>C	c.(1048-1050)CGG>CGC	p.R350R	CLCN2_uc003foh.2_5'UTR|CLCN2_uc010hya.1_Silent_p.R350R|CLCN2_uc011brl.1_Silent_p.R350R|CLCN2_uc011brm.1_Silent_p.R306R|CLCN2_uc011brn.1_Silent_p.R350R	NM_004366	NP_004357	P51788	CLCN2_HUMAN	chloride channel 2	350						chloride channel complex	voltage-gated chloride channel activity				0	all_cancers(143;6.66e-11)|Ovarian(172;0.0339)		Epithelial(37;2.22e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Lubiprostone(DB01046)	TTTTCTGCTTCCGCATCACCT	0.532													6	29	---	---	---	---	PASS
PROM1	8842	broad.mit.edu	37	4	16035000	16035000	+	Nonsense_Mutation	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr4:16035000G>A	uc003goo.2	-	4	648	c.436C>T	c.(436-438)CGA>TGA	p.R146*	PROM1_uc003gor.2_Nonsense_Mutation_p.R146*|PROM1_uc003gos.2_Nonsense_Mutation_p.R137*|PROM1_uc003got.2_Nonsense_Mutation_p.R146*|PROM1_uc003gou.2_Nonsense_Mutation_p.R137*|PROM1_uc003gop.2_Nonsense_Mutation_p.R137*|PROM1_uc003goq.3_Nonsense_Mutation_p.R137*|PROM1_uc010iec.1_Nonsense_Mutation_p.R24*	NM_006017	NP_006008	O43490	PROM1_HUMAN	prominin 1 isoform 1	146	Cytoplasmic (Potential).				camera-type eye photoreceptor cell differentiation|photoreceptor cell maintenance|retina layer formation	apical plasma membrane|cell surface|integral to plasma membrane|microvillus membrane|photoreceptor outer segment membrane|plasma membrane	beta-actinin binding|cadherin binding			ovary(3)|upper_aerodigestive_tract(1)|lung(1)|kidney(1)|central_nervous_system(1)	7						TCCTTCTGTCGCTGGTGCATT	0.433													9	56	---	---	---	---	PASS
YIPF7	285525	broad.mit.edu	37	4	44638039	44638039	+	Silent	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr4:44638039C>A	uc010ifx.1	-	3	269	c.252G>T	c.(250-252)TCG>TCT	p.S84S	YIPF7_uc010ify.1_Silent_p.S84S	NM_182592	NP_872398	Q8N8F6	YIPF7_HUMAN	Yip1 domain family, member 7	84						endoplasmic reticulum membrane|integral to membrane					0						CTGCGTAACCCGATGACATGA	0.413													24	25	---	---	---	---	PASS
ATP10D	57205	broad.mit.edu	37	4	47514670	47514670	+	Missense_Mutation	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr4:47514670G>A	uc003gxk.1	+	2	277	c.113G>A	c.(112-114)CGC>CAC	p.R38H	ATP10D_uc003gxj.3_Missense_Mutation_p.R38H	NM_020453	NP_065186	Q9P241	AT10D_HUMAN	ATPase, class V, type 10D	38	Cytoplasmic (Potential).				ATP biosynthetic process|cation transport	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|pancreas(1)	3						GCCTGTGGGCGCAAGTCCTCT	0.542													4	71	---	---	---	---	PASS
CWH43	80157	broad.mit.edu	37	4	49005812	49005812	+	Missense_Mutation	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr4:49005812G>A	uc003gyv.2	+	7	1045	c.863G>A	c.(862-864)TGT>TAT	p.C288Y	CWH43_uc011bzl.1_Missense_Mutation_p.C261Y	NM_025087	NP_079363	Q9H720	PG2IP_HUMAN	cell wall biogenesis 43 C-terminal homolog	288	Helical; (Potential).				GPI anchor biosynthetic process	integral to membrane				skin(2)|ovary(1)	3						GTGTCTGGCTGTGTCTTCGCC	0.502													52	49	---	---	---	---	PASS
TECRL	253017	broad.mit.edu	37	4	65180419	65180419	+	Silent	SNP	T	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr4:65180419T>C	uc003hcv.2	-	5	607	c.498A>G	c.(496-498)CCA>CCG	p.P166P	TECRL_uc003hcw.2_Silent_p.P166P	NM_001010874	NP_001010874	Q5HYJ1	TECRL_HUMAN	steroid 5 alpha-reductase 2-like 2	166					lipid metabolic process	cytoplasm|integral to membrane	oxidoreductase activity, acting on the CH-CH group of donors				0						CATATATACATGGGATCCTCA	0.289													3	77	---	---	---	---	PASS
MIR1269	100302177	broad.mit.edu	37	4	67142549	67142549	+	RNA	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr4:67142549C>A	hsa-mir-1269|MI0006406	+			c.8C>A																				0						cactggattgcctagaccagg	0.000													80	83	---	---	---	---	PASS
SLC4A4	8671	broad.mit.edu	37	4	72316958	72316958	+	Missense_Mutation	SNP	A	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr4:72316958A>G	uc003hfy.2	+	11	1379	c.1262A>G	c.(1261-1263)CAT>CGT	p.H421R	SLC4A4_uc010iic.2_Missense_Mutation_p.H421R|SLC4A4_uc010iib.2_Missense_Mutation_p.H421R|SLC4A4_uc003hfz.2_Missense_Mutation_p.H421R|SLC4A4_uc003hgc.3_Missense_Mutation_p.H377R|SLC4A4_uc010iid.2_5'UTR|SLC4A4_uc003hga.2_Missense_Mutation_p.H299R|SLC4A4_uc003hgb.3_Missense_Mutation_p.H377R	NM_001098484	NP_001091954	Q9Y6R1	S4A4_HUMAN	solute carrier family 4, sodium bicarbonate	421	Cytoplasmic (Potential).					basolateral plasma membrane|integral to plasma membrane	inorganic anion exchanger activity|protein binding|sodium:bicarbonate symporter activity			ovary(3)|kidney(1)|skin(1)	5			Lung(101;0.0739)|LUSC - Lung squamous cell carcinoma(112;0.225)			GATACGCCCCATGATGGAGGT	0.443													45	41	---	---	---	---	PASS
MTTP	4547	broad.mit.edu	37	4	100522794	100522794	+	Missense_Mutation	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr4:100522794G>A	uc003hvc.3	+	11	1523	c.1267G>A	c.(1267-1269)GAC>AAC	p.D423N	MTTP_uc011cej.1_Missense_Mutation_p.D450N	NM_000253	NP_000244	P55157	MTP_HUMAN	microsomal triglyceride transfer protein large	423	Vitellogenin.				lipid metabolic process|lipoprotein metabolic process	endoplasmic reticulum lumen	lipid binding|lipid transporter activity			ovary(3)|central_nervous_system(1)	4				OV - Ovarian serous cystadenocarcinoma(123;6.04e-09)	Hesperetin(DB01094)	TGGTAGCAGTGACATCAGAGA	0.358													60	76	---	---	---	---	PASS
AGXT2L1	64850	broad.mit.edu	37	4	109674095	109674095	+	Missense_Mutation	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr4:109674095C>T	uc003hzc.2	-	6	755	c.574G>A	c.(574-576)GAA>AAA	p.E192K	AGXT2L1_uc010imc.2_Missense_Mutation_p.E186K|AGXT2L1_uc011cfm.1_Missense_Mutation_p.E152K|AGXT2L1_uc011cfn.1_Missense_Mutation_p.E119K|AGXT2L1_uc011cfo.1_Missense_Mutation_p.E134K	NM_031279	NP_112569	Q8TBG4	AT2L1_HUMAN	alanine-glyoxylate aminotransferase 2-like 1	192					cellular amino acid metabolic process	mitochondrion	alanine-glyoxylate transaminase activity|pyridoxal phosphate binding			ovary(1)	1				OV - Ovarian serous cystadenocarcinoma(123;0.000281)		TTCTTCACTTCATCTGCATAA	0.363													42	44	---	---	---	---	PASS
ANP32C	23520	broad.mit.edu	37	4	165118178	165118178	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr4:165118178C>A	uc011cjk.1	-	1	686	c.686G>T	c.(685-687)AGG>ATG	p.R229M	MARCH1_uc003iqs.1_Intron	NM_012403	NP_036535	O43423	AN32C_HUMAN	acidic nuclear phosphoprotein 32C	229											0	all_hematologic(180;0.203)	Prostate(90;0.0138)|Melanoma(52;0.18)|all_neural(102;0.223)		KIRC - Kidney renal clear cell carcinoma(143;0.242)		cttctgacccctttcttcttc	0.050													20	16	---	---	---	---	PASS
DDX60	55601	broad.mit.edu	37	4	169204618	169204618	+	Silent	SNP	C	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr4:169204618C>G	uc003irp.2	-	13	1993	c.1701G>C	c.(1699-1701)GGG>GGC	p.G567G		NM_017631	NP_060101	Q8IY21	DDX60_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	567							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3		Prostate(90;0.00876)|Renal(120;0.0183)|all_neural(102;0.0837)|Melanoma(52;0.132)		GBM - Glioblastoma multiforme(119;0.0485)		TGCTCTTGGGCCCACTAAAAT	0.343													3	70	---	---	---	---	PASS
WDR17	116966	broad.mit.edu	37	4	177017731	177017731	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr4:177017731C>A	uc003iuj.2	+	2	217	c.61C>A	c.(61-63)CAA>AAA	p.Q21K	WDR17_uc003iuk.2_Intron|WDR17_uc003ium.3_Intron|WDR17_uc003iul.1_Intron	NM_170710	NP_733828	Q8IZU2	WDR17_HUMAN	WD repeat domain 17 isoform 1	21										ovary(2)|skin(2)|pancreas(1)|central_nervous_system(1)	6		Breast(14;0.00015)|Melanoma(52;0.00886)|Prostate(90;0.00996)|Renal(120;0.0183)|all_hematologic(60;0.107)|all_neural(102;0.164)		all cancers(43;2.21e-20)|Epithelial(43;9.71e-18)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-09)|GBM - Glioblastoma multiforme(59;0.000295)|STAD - Stomach adenocarcinoma(60;0.000703)|LUSC - Lung squamous cell carcinoma(193;0.0232)		TGAAGGACTACAAAGAGTAAG	0.338													22	34	---	---	---	---	PASS
KIAA0947	23379	broad.mit.edu	37	5	5465333	5465333	+	Silent	SNP	A	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr5:5465333A>C	uc003jdm.3	+	13	6108	c.5886A>C	c.(5884-5886)ACA>ACC	p.T1962T		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	1962										ovary(1)|central_nervous_system(1)	2						TTAGCACAACAAAAAAGGTAT	0.383													7	5	---	---	---	---	PASS
CDH12	1010	broad.mit.edu	37	5	22078744	22078744	+	Silent	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr5:22078744C>A	uc010iuc.2	-	2	500	c.42G>T	c.(40-42)CTG>CTT	p.L14L	CDH12_uc011cno.1_Silent_p.L14L|CDH12_uc003jgk.2_Silent_p.L14L	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	14					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						CTCCATCAAACAGAACCCAGA	0.453										HNSCC(59;0.17)			87	174	---	---	---	---	PASS
GDNF	2668	broad.mit.edu	37	5	37816199	37816199	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr5:37816199C>A	uc011cpi.1	-	3	390	c.190G>T	c.(190-192)GTC>TTC	p.V64F	GDNF_uc011cpc.1_Intron|GDNF_uc011cpd.1_Missense_Mutation_p.V12F|GDNF_uc011cpe.1_Missense_Mutation_p.V38F|GDNF_uc011cpf.1_Missense_Mutation_p.V38F|GDNF_uc011cpg.1_Missense_Mutation_p.V81F|GDNF_uc011cph.1_Missense_Mutation_p.V55F	NM_000514	NP_000505	P39905	GDNF_HUMAN	glial cell derived neurotrophic factor isoform 1	64					adult locomotory behavior|anti-apoptosis|axon guidance|branching involved in ureteric bud morphogenesis|enteric nervous system development|mRNA stabilization|negative regulation of neuron apoptosis|neural crest cell migration|peristalsis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of dopamine secretion|positive regulation of monooxygenase activity|positive regulation of transcription from RNA polymerase II promoter|positive regulation of ureteric bud formation|postganglionic parasympathetic nervous system development|regulation of dopamine uptake|signal transduction|sympathetic nervous system development	extracellular region	growth factor activity|protein homodimerization activity				0	all_lung(31;0.00118)					AAATCCATGACATCATCGAAC	0.413													35	59	---	---	---	---	PASS
IPO11	51194	broad.mit.edu	37	5	61779058	61779058	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr5:61779058G>T	uc003jtc.2	+	10	1149	c.959G>T	c.(958-960)TGT>TTT	p.C320F	IPO11_uc011cqr.1_Missense_Mutation_p.C360F|IPO11_uc003jtb.1_Missense_Mutation_p.C320F	NM_016338	NP_057422	Q9UI26	IPO11_HUMAN	Ran binding protein 11 isoform 2	320	HEAT 3.					cytoplasm|nucleus	protein binding			lung(2)|skin(2)	4		Lung NSC(810;8.99e-06)|Prostate(74;0.0235)|Ovarian(174;0.0511)|Breast(144;0.077)		Lung(70;0.0613)		ATTGTCCAATGTATGAATCTT	0.294													22	23	---	---	---	---	PASS
ADAMTS6	11174	broad.mit.edu	37	5	64483906	64483906	+	Silent	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr5:64483906G>T	uc003jtp.2	-	22	3661	c.2847C>A	c.(2845-2847)GTC>GTA	p.V949V	ADAMTS6_uc003jto.2_RNA|ADAMTS6_uc003jtq.2_RNA	NM_197941	NP_922932	Q9UKP5	ATS6_HUMAN	ADAM metallopeptidase with thrombospondin type 1	949	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		GCTCTTTTTCGACAGGCCGGT	0.507													66	74	---	---	---	---	PASS
KCNN2	3781	broad.mit.edu	37	5	113740157	113740157	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr5:113740157C>A	uc003kqo.2	+	3	1062	c.605C>A	c.(604-606)GCA>GAA	p.A202E		NM_021614	NP_067627	Q9H2S1	KCNN2_HUMAN	small conductance calcium-activated potassium	202						integral to membrane	calmodulin binding|small conductance calcium-activated potassium channel activity			ovary(2)	2		all_cancers(142;2.86e-05)|all_epithelial(76;9.33e-06)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Breast(839;0.159)|Lung NSC(810;0.174)|all_lung(232;0.206)		OV - Ovarian serous cystadenocarcinoma(64;1.89e-08)|Epithelial(69;2.04e-08)|all cancers(49;3.74e-06)|COAD - Colon adenocarcinoma(37;0.142)|Colorectal(14;0.195)		GACAATGGAGCAGATGACTGG	0.383													58	66	---	---	---	---	PASS
PCDHGA2	56113	broad.mit.edu	37	5	140720231	140720231	+	Missense_Mutation	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr5:140720231C>T	uc003ljk.1	+	1	1878	c.1693C>T	c.(1693-1695)CCT>TCT	p.P565S	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc011dao.1_Missense_Mutation_p.P565S	NM_018915	NP_061738	Q9Y5H1	PCDG2_HUMAN	protocadherin gamma subfamily A, 2 isoform 1	565	Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			skin(2)|ovary(1)	3			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATCCTGTACCCTGCCTTCCC	0.632													73	63	---	---	---	---	PASS
FAM71B	153745	broad.mit.edu	37	5	156590281	156590281	+	Missense_Mutation	SNP	C	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr5:156590281C>G	uc003lwn.2	-	2	1095	c.995G>C	c.(994-996)GGT>GCT	p.G332A		NM_130899	NP_570969	Q8TC56	FA71B_HUMAN	family with sequence similarity 71, member B	332						nucleus				ovary(4)|pancreas(1)|skin(1)	6	Renal(175;0.00212)	Medulloblastoma(196;0.0523)|all_neural(177;0.21)	Kidney(164;0.000171)|KIRC - Kidney renal clear cell carcinoma(164;0.000785)			GTTGGCAGCACCTGCCATGGA	0.562													9	159	---	---	---	---	PASS
DPCR1	135656	broad.mit.edu	37	6	30919763	30919763	+	Silent	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr6:30919763G>A	uc003nsg.2	+	2	3522	c.3522G>A	c.(3520-3522)ACG>ACA	p.T1174T		NM_080870	NP_543146	Q3MIW9	DPCR1_HUMAN	diffuse panbronchiolitis critical region 1	305	Extracellular (Potential).|Thr-rich.					integral to membrane					0						AAAAGACCACGTCAACCACAG	0.468													5	63	---	---	---	---	PASS
SLC26A8	116369	broad.mit.edu	37	6	35922948	35922948	+	Missense_Mutation	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr6:35922948C>T	uc003olm.2	-	17	2324	c.2213G>A	c.(2212-2214)GGG>GAG	p.G738E	SLC26A8_uc010jwa.2_RNA|SLC26A8_uc003olk.2_Missense_Mutation_p.G320E|SLC26A8_uc003oln.2_Missense_Mutation_p.G738E|SLC26A8_uc003oll.2_Missense_Mutation_p.G633E	NM_052961	NP_443193	Q96RN1	S26A8_HUMAN	solute carrier family 26, member 8 isoform a	738	Interaction with RACGAP1.|STAS.|Cytoplasmic (Potential).				cell differentiation|meiosis|multicellular organismal development|spermatogenesis	integral to membrane|plasma membrane	anion:anion antiporter activity|chloride channel activity|oxalate transmembrane transporter activity|protein binding|sulfate transmembrane transporter activity			ovary(2)	2						TACGACTAACCCCCGTGAATC	0.527													37	43	---	---	---	---	PASS
PRIM2	5558	broad.mit.edu	37	6	57467142	57467142	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr6:57467142C>A	uc003pdx.2	+	12	1170	c.1083C>A	c.(1081-1083)GAC>GAA	p.D361E		NM_000947	NP_000938	P49643	PRI2_HUMAN	DNA primase polypeptide 2	361					DNA replication, synthesis of RNA primer|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication	alpha DNA polymerase:primase complex|nucleoplasm	4 iron, 4 sulfur cluster binding|DNA binding|DNA primase activity|metal ion binding				0				Colorectal(6;0.041)|READ - Rectum adenocarcinoma(7;0.193)		AGAGGACAGACTATACACCTT	0.438													9	103	---	---	---	---	PASS
B3GAT2	135152	broad.mit.edu	37	6	71666003	71666003	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr6:71666003C>A	uc003pfv.2	-	1	786	c.130G>T	c.(130-132)GCG>TCG	p.A44S	B3GAT2_uc011dxz.1_RNA|B3GAT2_uc003pfw.2_Missense_Mutation_p.A44S	NM_080742	NP_542780	Q9NPZ5	B3GA2_HUMAN	beta-1,3-glucuronyltransferase 2	44	Lumenal (Potential).				carbohydrate biosynthetic process	Golgi membrane|integral to membrane	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity|metal ion binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						CGGCCCACCGCGTAGGGAGAG	0.706													6	6	---	---	---	---	PASS
SNAP91	9892	broad.mit.edu	37	6	84417641	84417641	+	Silent	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr6:84417641C>A	uc011dze.1	-	2	323	c.6G>T	c.(4-6)TCG>TCT	p.S2S	SNAP91_uc003pkb.2_5'UTR|SNAP91_uc003pkc.2_Silent_p.S2S|SNAP91_uc003pkd.2_Silent_p.S2S|SNAP91_uc003pka.2_Silent_p.S2S|SNAP91_uc011dzf.1_5'UTR	NM_014841	NP_055656	O60641	AP180_HUMAN	synaptosomal-associated protein, 91kDa homolog	2					clathrin coat assembly	clathrin coat|coated pit|plasma membrane	1-phosphatidylinositol binding|clathrin binding			ovary(1)	1		all_cancers(76;0.000243)|Acute lymphoblastic leukemia(125;2.91e-07)|all_hematologic(105;0.000337)|all_epithelial(107;0.0575)		BRCA - Breast invasive adenocarcinoma(397;0.0967)		GCGTTTGGCCCGACATCTTCT	0.587													24	13	---	---	---	---	PASS
GPRC6A	222545	broad.mit.edu	37	6	117113452	117113452	+	Silent	SNP	G	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr6:117113452G>C	uc003pxj.1	-	6	2656	c.2634C>G	c.(2632-2634)GTC>GTG	p.V878V	GPRC6A_uc003pxk.1_Silent_p.V703V|GPRC6A_uc003pxl.1_Silent_p.V807V	NM_148963	NP_683766	Q5T6X5	GPC6A_HUMAN	G protein-coupled receptor, family C, group 6,	878	Cytoplasmic (Potential).				response to amino acid stimulus		G-protein coupled receptor activity			ovary(4)|skin(2)	6		all_cancers(87;0.0314)|all_epithelial(87;0.0216)|Colorectal(196;0.234)		GBM - Glioblastoma multiforme(226;0.0265)|all cancers(137;0.0554)|OV - Ovarian serous cystadenocarcinoma(136;0.07)		TGGTCATTGTGACATTGCCGC	0.478													56	47	---	---	---	---	PASS
LAMA2	3908	broad.mit.edu	37	6	129612857	129612857	+	Missense_Mutation	SNP	A	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr6:129612857A>G	uc003qbn.2	+	20	2953	c.2848A>G	c.(2848-2850)AAA>GAA	p.K950E	LAMA2_uc003qbo.2_Missense_Mutation_p.K950E	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	950	Laminin EGF-like 9.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GAGATGTGACAAATGCAAGGT	0.443													28	22	---	---	---	---	PASS
AGPAT4	56895	broad.mit.edu	37	6	161587397	161587397	+	Silent	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr6:161587397C>T	uc003qtr.1	-	3	458	c.231G>A	c.(229-231)ACG>ACA	p.T77T	AGPAT4_uc003qts.1_Intron|AGPAT4_uc011egb.1_Intron|AGPAT4_uc003qtt.1_RNA|AGPAT4_uc011egc.1_Silent_p.T77T|AGPAT4_uc011egd.1_Silent_p.T15T|AGPAT4_uc011ege.1_Intron	NM_020133	NP_064518	Q9NRZ5	PLCD_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 4	77					phospholipid biosynthetic process	integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity|protein binding				0		Breast(66;0.000289)|Ovarian(120;0.0266)|Prostate(117;0.0285)		OV - Ovarian serous cystadenocarcinoma(65;2.23e-17)|BRCA - Breast invasive adenocarcinoma(81;3.58e-05)		CGCGCGGGTCCGTGAAGATGG	0.527													23	32	---	---	---	---	PASS
INTS1	26173	broad.mit.edu	37	7	1527456	1527456	+	Missense_Mutation	SNP	T	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr7:1527456T>C	uc003skn.2	-	19	2557	c.2456A>G	c.(2455-2457)AAG>AGG	p.K819R	INTS1_uc003skp.1_Missense_Mutation_p.K166R	NM_001080453	NP_001073922	Q8N201	INT1_HUMAN	integrator complex subunit 1	819					snRNA processing	integral to membrane|integrator complex|nuclear membrane					0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0181)|OV - Ovarian serous cystadenocarcinoma(56;6.99e-15)		GATGGTCTGCTTGGTGGACGC	0.692													18	62	---	---	---	---	PASS
STK31	56164	broad.mit.edu	37	7	23757098	23757098	+	Splice_Site	SNP	A	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr7:23757098A>G	uc003sws.3	+	4	218	c.151_splice	c.e4-2	p.S51_splice	STK31_uc003swt.3_Splice_Site_p.S28_splice|STK31_uc011jze.1_Splice_Site_p.S51_splice|STK31_uc010kuq.2_Splice_Site_p.S28_splice	NM_031414	NP_113602	Q9BXU1	STK31_HUMAN	serine/threonine kinase 31 isoform a								ATP binding|nucleic acid binding|protein serine/threonine kinase activity			skin(3)|lung(2)|ovary(2)|stomach(2)	9						TAATCTTTCTAGAGTATCAAT	0.353													13	28	---	---	---	---	PASS
NFE2L3	9603	broad.mit.edu	37	7	26224208	26224208	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr7:26224208C>A	uc003sxq.2	+	4	1162	c.890C>A	c.(889-891)TCT>TAT	p.S297Y		NM_004289	NP_004280	Q9Y4A8	NF2L3_HUMAN	nuclear factor erythroid 2-like 3	297					transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			skin(3)|ovary(1)	4						GGCATGAATTCTTCAGCACAT	0.403													18	166	---	---	---	---	PASS
PLEKHA8	84725	broad.mit.edu	37	7	30101578	30101578	+	Silent	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr7:30101578C>T	uc003tam.1	+	11	1255	c.1164C>T	c.(1162-1164)CAC>CAT	p.H388H	PLEKHA8_uc003tao.2_Silent_p.H272H|PLEKHA8_uc003tap.1_Silent_p.H388H|PLEKHA8_uc003tan.2_Silent_p.H388H	NM_032639	NP_116028	Q96JA3	PKHA8_HUMAN	pleckstrin homology domain containing, family A	388					protein transport	cytoplasm	glycolipid binding|glycolipid transporter activity			breast(3)|ovary(1)	4						TAGTGCTGCACGAAGTGGAGG	0.473											OREG0017934	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	30	---	---	---	---	PASS
INMT	11185	broad.mit.edu	37	7	30793447	30793447	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr7:30793447C>A	uc003tbs.1	+	2	271	c.255C>A	c.(253-255)GAC>GAA	p.D85E	FAM188B_uc010kwe.2_5'UTR|INMT_uc010kwc.1_RNA|INMT_uc010kwd.1_Missense_Mutation_p.D84E	NM_006774	NP_006765	O95050	INMT_HUMAN	indolethylamine N-methyltransferase	85	S-adenosyl-L-methionine binding.					cytoplasm	amine N-methyltransferase activity				0						CTCTCTCCGACTTTACCGACC	0.567													105	172	---	---	---	---	PASS
BBS9	27241	broad.mit.edu	37	7	33407434	33407434	+	Missense_Mutation	SNP	A	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr7:33407434A>T	uc003tdn.1	+	17	2262	c.1749A>T	c.(1747-1749)TTA>TTT	p.L583F	BBS9_uc003tdo.1_Missense_Mutation_p.L548F|BBS9_uc003tdp.1_Missense_Mutation_p.L578F|BBS9_uc003tdq.1_Missense_Mutation_p.L543F|BBS9_uc010kwn.1_RNA|BBS9_uc003tdr.1_Missense_Mutation_p.L107F|BBS9_uc003tds.1_Missense_Mutation_p.L6F|BBS9_uc011kao.1_Missense_Mutation_p.L461F	NM_198428	NP_940820	Q3SYG4	PTHB1_HUMAN	parathyroid hormone-responsive B1 isoform 2	583					fat cell differentiation|response to stimulus|visual perception	BBSome|cilium membrane|microtubule organizing center|nucleus	protein binding			ovary(3)|upper_aerodigestive_tract(1)|skin(1)	5			GBM - Glioblastoma multiforme(11;0.0894)			TTCACTTCTTAGGAGGTGCTC	0.363									Bardet-Biedl_syndrome				22	111	---	---	---	---	PASS
ADCY1	107	broad.mit.edu	37	7	45725649	45725649	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr7:45725649C>A	uc003tne.3	+	13	2180	c.2162C>A	c.(2161-2163)ACC>AAC	p.T721N		NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	721					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GCCCTGCCCACCCTGCCCTGC	0.637													17	34	---	---	---	---	PASS
UPP1	7378	broad.mit.edu	37	7	48146663	48146663	+	Silent	SNP	C	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr7:48146663C>G	uc003toj.2	+	8	1159	c.630C>G	c.(628-630)ACC>ACG	p.T210T	UPP1_uc003tok.2_Silent_p.T210T|UPP1_uc003tol.2_Silent_p.T210T|UPP1_uc011kch.1_Silent_p.T3T|UPP1_uc003ton.2_Silent_p.T73T|UPP1_uc003too.2_Silent_p.T73T	NM_181597	NP_853628	Q16831	UPP1_HUMAN	uridine phosphorylase 1	210					nucleotide catabolic process|pyrimidine base metabolic process|pyrimidine nucleoside catabolic process|pyrimidine nucleoside salvage	cytosol	uridine phosphorylase activity				0						CCATGTGCACCTTGGACTTCT	0.577													26	42	---	---	---	---	PASS
GRB10	2887	broad.mit.edu	37	7	50680468	50680468	+	Silent	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr7:50680468C>A	uc003tpi.2	-	10	1195	c.1164G>T	c.(1162-1164)ACG>ACT	p.T388T	GRB10_uc003tph.3_Silent_p.T330T|GRB10_uc003tpj.2_Silent_p.T342T|GRB10_uc003tpk.2_Silent_p.T388T|GRB10_uc010kzb.2_Silent_p.T330T|GRB10_uc003tpl.2_Silent_p.T382T|GRB10_uc003tpm.2_Silent_p.T330T|GRB10_uc003tpn.2_Silent_p.T330T	NM_005311	NP_005302	Q13322	GRB10_HUMAN	growth factor receptor-bound protein 10 isoform	388	PH.				insulin receptor signaling pathway|insulin receptor signaling pathway|negative regulation of glucose import|negative regulation of glycogen biosynthetic process|negative regulation of insulin receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of phosphorylation|positive regulation of vascular endothelial growth factor receptor signaling pathway	cytosol|plasma membrane	insulin receptor binding|insulin receptor binding|SH3/SH2 adaptor activity			lung(3)|ovary(2)|upper_aerodigestive_tract(1)	6	Glioma(55;0.08)|all_neural(89;0.245)					TCATCCAGCACGTCCTGGTTT	0.473									Russell-Silver_syndrome				8	35	---	---	---	---	PASS
HIP1	3092	broad.mit.edu	37	7	75228545	75228545	+	Silent	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr7:75228545G>A	uc003uds.1	-	2	182	c.141C>T	c.(139-141)GCC>GCT	p.A47A		NM_005338	NP_005329	O00291	HIP1_HUMAN	huntingtin interacting protein 1	47	ENTH.				activation of caspase activity|cell differentiation|clathrin coat assembly|endocytosis|induction of apoptosis|positive regulation of receptor-mediated endocytosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	clathrin coated vesicle membrane|cytoskeleton|Golgi apparatus|membrane fraction|nucleus	actin binding|clathrin binding|phosphatidylinositol binding|structural constituent of cytoskeleton			lung(3)|pancreas(2)|ovary(1)|breast(1)|central_nervous_system(1)	8						GCGTATTAATGGCCTTATTGA	0.502			T	PDGFRB	CMML								29	142	---	---	---	---	PASS
ZAN	7455	broad.mit.edu	37	7	100364844	100364844	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr7:100364844C>A	uc003uwj.2	+	25	4989	c.4824C>A	c.(4822-4824)GAC>GAA	p.D1608E	ZAN_uc003uwk.2_Missense_Mutation_p.D1608E|ZAN_uc003uwl.2_RNA|ZAN_uc010lhh.2_RNA|ZAN_uc010lhi.2_RNA|ZAN_uc011kkd.1_Missense_Mutation_p.D185E	NM_003386	NP_003377	Q9Y493	ZAN_HUMAN	zonadhesin isoform 3	1608	Extracellular (Potential).|VWFD 2.				binding of sperm to zona pellucida|cell-cell adhesion	integral to membrane|plasma membrane				ovary(4)|large_intestine(3)|central_nervous_system(2)|pancreas(2)	11	Lung NSC(181;0.041)|all_lung(186;0.0581)		STAD - Stomach adenocarcinoma(171;0.19)			CAGTCTTTGACCTCAGCATCT	0.577													9	45	---	---	---	---	PASS
ATXN7L1	222255	broad.mit.edu	37	7	105516902	105516902	+	Missense_Mutation	SNP	T	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr7:105516902T>C	uc003vde.2	-	1	130	c.103A>G	c.(103-105)AAA>GAA	p.K35E	ATXN7L1_uc003vdi.2_Missense_Mutation_p.K35E|CDHR3_uc003vdk.2_5'Flank|uc003vdj.1_5'Flank	NM_020725	NP_065776	Q9ULK2	AT7L1_HUMAN	ataxin 7-like 1 isoform 1	35											0						CTGGGCACTTTGCGATCCAGT	0.582													5	29	---	---	---	---	PASS
PIK3CG	5294	broad.mit.edu	37	7	106508148	106508148	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr7:106508148C>A	uc003vdv.3	+	2	227	c.142C>A	c.(142-144)CAG>AAG	p.Q48K	PIK3CG_uc003vdu.2_Missense_Mutation_p.Q48K|PIK3CG_uc003vdw.2_Missense_Mutation_p.Q48K	NM_002649	NP_002640	P48736	PK3CG_HUMAN	phosphoinositide-3-kinase, catalytic, gamma	48					G-protein coupled receptor protein signaling pathway|phosphatidylinositol-mediated signaling|platelet activation	phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity|protein binding			lung(16)|central_nervous_system(8)|breast(5)|pancreas(3)|stomach(2)|ovary(2)|upper_aerodigestive_tract(1)|skin(1)	38						GCCCACCAGCCAGCGCAAATG	0.672													8	53	---	---	---	---	PASS
FAM3C	10447	broad.mit.edu	37	7	121004196	121004196	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr7:121004196C>A	uc003vjx.2	-	6	567	c.319G>T	c.(319-321)GCC>TCC	p.A107S	FAM3C_uc010lkm.2_Missense_Mutation_p.A107S	NM_014888	NP_055703	Q92520	FAM3C_HUMAN	family with sequence similarity 3, member C	107					multicellular organismal development	cytoplasmic membrane-bounded vesicle|extracellular region	cytokine activity				0	all_neural(327;0.117)					TTTGCCAAGGCAACATTGATC	0.318													6	48	---	---	---	---	PASS
PTPRZ1	5803	broad.mit.edu	37	7	121651116	121651116	+	Silent	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr7:121651116C>T	uc003vjy.2	+	12	2411	c.2016C>T	c.(2014-2016)AGC>AGT	p.S672S	PTPRZ1_uc003vjz.2_Silent_p.S672S|PTPRZ1_uc011knt.1_Silent_p.S122S	NM_002851	NP_002842	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type,	672	Extracellular (Potential).				central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			ovary(3)|large_intestine(2)|lung(2)|central_nervous_system(1)|kidney(1)	9						GCAGAGAGAGCTTTCTCCAGA	0.463													13	64	---	---	---	---	PASS
IQUB	154865	broad.mit.edu	37	7	123152383	123152383	+	Missense_Mutation	SNP	T	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr7:123152383T>A	uc003vkn.2	-	2	589	c.12A>T	c.(10-12)CAA>CAT	p.Q4H	IQUB_uc003vko.2_Missense_Mutation_p.Q4H|IQUB_uc010lkt.2_RNA|IQUB_uc003vkp.1_Missense_Mutation_p.Q4H|IQUB_uc003vkq.2_Missense_Mutation_p.Q4H	NM_178827	NP_849149	Q8NA54	IQUB_HUMAN	IQ motif and ubiquitin domain containing	4				Q -> R (in Ref. 1; BAC04074).						ovary(3)|large_intestine(1)	4						ACTTCTCCTGTTGATTAGACA	0.328													6	39	---	---	---	---	PASS
GRM8	2918	broad.mit.edu	37	7	126173479	126173479	+	Missense_Mutation	SNP	C	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr7:126173479C>G	uc003vlr.2	-	8	2268	c.1957G>C	c.(1957-1959)GTC>CTC	p.V653L	GRM8_uc003vls.2_RNA|GRM8_uc011kof.1_RNA|GRM8_uc003vlt.2_Missense_Mutation_p.V653L|GRM8_uc010lkz.1_RNA	NM_000845	NP_000836	O00222	GRM8_HUMAN	glutamate receptor, metabotropic 8 isoform a	653	Helical; Name=3; (Potential).				negative regulation of cAMP biosynthetic process|sensory perception of smell|visual perception	integral to plasma membrane				lung(15)|ovary(5)|pancreas(1)|breast(1)|skin(1)	23		Prostate(267;0.186)			L-Glutamic Acid(DB00142)	CCTAGGAAGACCCGTCGGAAG	0.448										HNSCC(24;0.065)			37	65	---	---	---	---	PASS
EXOC4	60412	broad.mit.edu	37	7	133059665	133059665	+	Missense_Mutation	SNP	A	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr7:133059665A>T	uc003vrk.2	+	7	1126	c.1091A>T	c.(1090-1092)CAG>CTG	p.Q364L	EXOC4_uc011kpo.1_Missense_Mutation_p.Q263L|EXOC4_uc003vri.2_Missense_Mutation_p.Q364L|EXOC4_uc003vrj.2_Missense_Mutation_p.Q364L	NM_021807	NP_068579	Q96A65	EXOC4_HUMAN	SEC8 protein isoform a	364					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			ovary(4)|large_intestine(3)|upper_aerodigestive_tract(1)|skin(1)	9		Esophageal squamous(399;0.129)				GGATACCTGCAGGACACTGTA	0.458													10	71	---	---	---	---	PASS
MLL3	58508	broad.mit.edu	37	7	151884527	151884527	+	Missense_Mutation	SNP	C	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr7:151884527C>G	uc003wla.2	-	33	5047	c.4828G>C	c.(4828-4830)GAT>CAT	p.D1610H	MLL3_uc003wkz.2_Missense_Mutation_p.D671H	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	1610					intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		TTGTTAGGATCACTTGCCATT	0.363			N		medulloblastoma								104	200	---	---	---	---	PASS
ST18	9705	broad.mit.edu	37	8	53084559	53084559	+	Missense_Mutation	SNP	C	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr8:53084559C>G	uc003xqz.2	-	5	1018	c.862G>C	c.(862-864)GTA>CTA	p.V288L	ST18_uc011ldq.1_5'UTR|ST18_uc011ldr.1_Missense_Mutation_p.V253L|ST18_uc011lds.1_Missense_Mutation_p.V193L|ST18_uc003xra.2_Missense_Mutation_p.V288L|ST18_uc003xrb.2_Missense_Mutation_p.V288L	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	288						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TCCGTCATTACTGCCAGGCTC	0.537													54	57	---	---	---	---	PASS
RB1CC1	9821	broad.mit.edu	37	8	53570240	53570240	+	Missense_Mutation	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr8:53570240C>T	uc003xre.3	-	15	2707	c.2149G>A	c.(2149-2151)GTT>ATT	p.V717I	RB1CC1_uc003xrf.3_Missense_Mutation_p.V717I	NM_014781	NP_055596	Q8TDY2	RBCC1_HUMAN	Rb1-inducible coiled coil protein 1 isoform 1	717					autophagy|cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding			ovary(8)|upper_aerodigestive_tract(1)|large_intestine(1)|skin(1)	11		all_cancers(86;0.137)|all_epithelial(80;0.00494)|Lung NSC(129;0.011)|all_lung(136;0.023)				TCTAAAGAAACTTGGTGAATA	0.348													54	36	---	---	---	---	PASS
PREX2	80243	broad.mit.edu	37	8	68934375	68934375	+	Missense_Mutation	SNP	G	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr8:68934375G>C	uc003xxv.1	+	4	468	c.441G>C	c.(439-441)TTG>TTC	p.L147F	PREX2_uc003xxu.1_Missense_Mutation_p.L147F|PREX2_uc011lez.1_Missense_Mutation_p.L82F	NM_024870	NP_079146	Q70Z35	PREX2_HUMAN	DEP domain containing 2 isoform a	147	DH.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction	intracellular	protein binding|Rac GTPase activator activity|Rac guanyl-nucleotide exchange factor activity			skin(6)|large_intestine(4)|pancreas(3)|lung(2)|ovary(1)|kidney(1)	17						CATTTCTTTTGGTAAGTGTAT	0.338													24	30	---	---	---	---	PASS
DCAF4L2	138009	broad.mit.edu	37	8	88885462	88885462	+	Silent	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr8:88885462C>A	uc003ydz.2	-	1	835	c.738G>T	c.(736-738)GGG>GGT	p.G246G		NM_152418	NP_689631	Q8NA75	DC4L2_HUMAN	WD repeat domain 21C	246										ovary(1)	1						CAAAGATCTCCCCAGAGCGAC	0.522													65	48	---	---	---	---	PASS
RIPK2	8767	broad.mit.edu	37	8	90798854	90798854	+	Missense_Mutation	SNP	A	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr8:90798854A>G	uc003yee.2	+	9	1377	c.1063A>G	c.(1063-1065)AGT>GGT	p.S355G	RIPK2_uc003yef.2_Missense_Mutation_p.S218G	NM_003821	NP_003812	O43353	RIPK2_HUMAN	receptor-interacting serine-threonine kinase 2	355					activation of MAPK activity|anti-apoptosis|apoptosis|inflammatory response|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of protein ubiquitination|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol	ATP binding|CARD domain binding|LIM domain binding|protein homodimerization activity|protein serine/threonine kinase activity|signal transducer activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(11;0.0474)			CCATGAAAATAGTGGTTCTCC	0.318													11	140	---	---	---	---	PASS
VPS13B	157680	broad.mit.edu	37	8	100454784	100454784	+	Missense_Mutation	SNP	G	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr8:100454784G>C	uc003yiv.2	+	23	3477	c.3366G>C	c.(3364-3366)AAG>AAC	p.K1122N	VPS13B_uc003yiw.2_Missense_Mutation_p.K1122N|VPS13B_uc003yiu.1_Missense_Mutation_p.K1122N|VPS13B_uc003yix.1_Missense_Mutation_p.K592N	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1122					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CTCAAATAAAGATTATTAGTG	0.418													55	49	---	---	---	---	PASS
GRHL2	79977	broad.mit.edu	37	8	102656426	102656426	+	Missense_Mutation	SNP	C	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr8:102656426C>G	uc010mbu.2	+	13	1915	c.1585C>G	c.(1585-1587)CAG>GAG	p.Q529E		NM_024915	NP_079191	Q6ISB3	GRHL2_HUMAN	transcription factor CP2-like 3	529						cytoplasm|nucleus	DNA binding			ovary(2)|skin(1)	3	all_cancers(14;4.39e-08)|all_epithelial(15;4.09e-10)|Lung NSC(17;7.11e-06)|all_lung(17;1.44e-05)		Epithelial(11;5.81e-09)|all cancers(13;3.81e-07)|OV - Ovarian serous cystadenocarcinoma(57;0.000213)			GCCTTCAAAGCAGATGAAAGA	0.502													3	47	---	---	---	---	PASS
EIF3E	3646	broad.mit.edu	37	8	109241415	109241415	+	Missense_Mutation	SNP	T	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr8:109241415T>C	uc003ymu.2	-	6	509	c.481A>G	c.(481-483)ACA>GCA	p.T161A	EIF3E_uc003ymt.2_Missense_Mutation_p.T112A|EIF3E_uc003ymv.2_Missense_Mutation_p.T68A|EIF3E_uc010mci.1_Missense_Mutation_p.T161A	NM_001568	NP_001559	P60228	EIF3E_HUMAN	eukaryotic translation initiation factor 3,	161	Sufficient for interaction with TRIM27.				negative regulation of translational initiation|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|eukaryotic translation initiation factor 3 complex|PML body	protein N-terminus binding			ovary(2)|kidney(1)	3			OV - Ovarian serous cystadenocarcinoma(57;6.84e-10)			TTTCTATCTGTTGCTGGAACC	0.363													40	45	---	---	---	---	PASS
FAM135B	51059	broad.mit.edu	37	8	139163936	139163936	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr8:139163936C>A	uc003yuy.2	-	13	2953	c.2782G>T	c.(2782-2784)GGT>TGT	p.G928C	FAM135B_uc003yux.2_Missense_Mutation_p.G829C|FAM135B_uc003yuz.2_RNA|FAM135B_uc003yva.2_Missense_Mutation_p.G490C|FAM135B_uc003yvb.2_Missense_Mutation_p.G490C	NM_015912	NP_056996	Q49AJ0	F135B_HUMAN	hypothetical protein LOC51059	928										ovary(7)|skin(2)	9	all_epithelial(106;8.29e-14)|Lung NSC(106;6.88e-06)|all_lung(105;1.44e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0805)			TGAGAGAGACCCTCAACCTCT	0.502										HNSCC(54;0.14)			91	75	---	---	---	---	PASS
ZNF517	340385	broad.mit.edu	37	8	146033405	146033405	+	Silent	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr8:146033405C>T	uc003zed.1	+	5	1211	c.1104C>T	c.(1102-1104)CAC>CAT	p.H368H	ZNF517_uc010mgd.1_Silent_p.H274H|ZNF517_uc003zee.1_RNA|ZNF517_uc011llm.1_Silent_p.H274H|ZNF517_uc003zef.1_Intron	NM_213605	NP_998770	Q6ZMY9	ZN517_HUMAN	zinc finger protein 517	368	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;1.03e-11)|all_epithelial(106;6.69e-11)|Lung NSC(106;4.08e-05)|all_lung(105;0.000125)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		Epithelial(56;5.47e-39)|OV - Ovarian serous cystadenocarcinoma(54;6.38e-39)|all cancers(56;5.47e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0355)|Colorectal(110;0.055)			ACCCGCCCCACGAGTGCCCGG	0.746													10	4	---	---	---	---	PASS
MLLT3	4300	broad.mit.edu	37	9	20414379	20414379	+	Silent	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr9:20414379G>A	uc003zoe.2	-	5	724	c.465C>T	c.(463-465)AGC>AGT	p.S155S	MLLT3_uc011lne.1_Silent_p.S123S|MLLT3_uc011lnf.1_Silent_p.S152S|MLLT3_uc003zof.2_5'UTR|MLLT3_uc011lng.1_Silent_p.S123S	NM_004529	NP_004520	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	155	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding			lung(2)|ovary(1)	3				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctactgctgctgctgc	0.149			T	MLL	ALL								5	69	---	---	---	---	PASS
GCNT1	2650	broad.mit.edu	37	9	79117766	79117766	+	Missense_Mutation	SNP	A	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr9:79117766A>G	uc010mpf.2	+	3	810	c.469A>G	c.(469-471)AAA>GAA	p.K157E	GCNT1_uc010mpg.2_Missense_Mutation_p.K157E|GCNT1_uc010mph.2_Missense_Mutation_p.K157E|GCNT1_uc004akf.3_Missense_Mutation_p.K157E|GCNT1_uc010mpi.2_Missense_Mutation_p.K157E|GCNT1_uc004akh.3_Missense_Mutation_p.K157E	NM_001490	NP_001481	Q02742	GCNT1_HUMAN	beta-1,3-galactosyl-O-glycosyl-glycoprotein	157	Lumenal (Potential).|Catalytic (By similarity).				protein O-linked glycosylation	Golgi membrane|integral to membrane	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity				0						TGTGGACACAAAATCCGAGGA	0.438													105	31	---	---	---	---	PASS
KIAA1529	57653	broad.mit.edu	37	9	100139102	100139102	+	Nonsense_Mutation	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr9:100139102C>T	uc011lut.1	+	49	6222	c.5449C>T	c.(5449-5451)CAG>TAG	p.Q1817*	KIAA1529_uc004axe.1_Nonsense_Mutation_p.Q1623*|KIAA1529_uc004axg.1_Nonsense_Mutation_p.Q1678*|KIAA1529_uc004axh.1_RNA|KIAA1529_uc011luw.1_Nonsense_Mutation_p.Q771*	NM_020893	NP_065944			hypothetical protein LOC57653											ovary(4)|large_intestine(2)|skin(1)	7		Acute lymphoblastic leukemia(62;0.154)				CTGTACATCTCAGATAAAGGA	0.502													47	36	---	---	---	---	PASS
ABCA1	19	broad.mit.edu	37	9	107549168	107549168	+	Silent	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr9:107549168C>T	uc004bcl.2	-	47	6607	c.6294G>A	c.(6292-6294)GTG>GTA	p.V2098V	NIPSNAP3B_uc004bcj.1_Intron	NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	2098	ABC transporter 2.				Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	GAGATGTAAGCACTACTGATC	0.433													74	61	---	---	---	---	PASS
IKBKAP	8518	broad.mit.edu	37	9	111640380	111640380	+	Silent	SNP	T	C	C	rs149038322		TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr9:111640380T>C	uc004bdm.3	-	35	4270	c.3750A>G	c.(3748-3750)GAA>GAG	p.E1250E	IKBKAP_uc004bdl.2_Silent_p.E901E|IKBKAP_uc011lwc.1_Silent_p.E1136E|IKBKAP_uc010mtq.2_Silent_p.E901E|IKBKAP_uc004bdk.2_Silent_p.E254E|IKBKAP_uc010mtp.2_RNA	NM_003640	NP_003631	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene	1250					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	7						CCCTTCCTTGTTCATCAAACT	0.378													66	30	---	---	---	---	PASS
ZFP37	7539	broad.mit.edu	37	9	115805750	115805750	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr9:115805750C>A	uc004bgm.1	-	4	1176	c.1148G>T	c.(1147-1149)GGG>GTG	p.G383V	ZFP37_uc011lwz.1_Missense_Mutation_p.G398V|ZFP37_uc011lxa.1_Missense_Mutation_p.G384V	NM_003408	NP_003399	Q9Y6Q3	ZFP37_HUMAN	zinc finger protein 37 homolog	383	C2H2-type 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						GAAGGTTTTCCCACATTCAGC	0.413													116	64	---	---	---	---	PASS
ZFP37	7539	broad.mit.edu	37	9	115805751	115805751	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr9:115805751C>A	uc004bgm.1	-	4	1175	c.1147G>T	c.(1147-1149)GGG>TGG	p.G383W	ZFP37_uc011lwz.1_Missense_Mutation_p.G398W|ZFP37_uc011lxa.1_Missense_Mutation_p.G384W	NM_003408	NP_003399	Q9Y6Q3	ZFP37_HUMAN	zinc finger protein 37 homolog	383	C2H2-type 4.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						AAGGTTTTCCCACATTCAGCA	0.413													117	64	---	---	---	---	PASS
COL5A1	1289	broad.mit.edu	37	9	137674557	137674557	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr9:137674557G>T	uc004cfe.2	+	29	2857	c.2475G>T	c.(2473-2475)AAG>AAT	p.K825N		NM_000093	NP_000084	P20908	CO5A1_HUMAN	alpha 1 type V collagen preproprotein	825	Triple-helical region.				axon guidance|cell adhesion|collagen biosynthetic process|collagen fibril organization|eye morphogenesis|fibril organization|integrin biosynthetic process|skin development|wound healing, spreading of epidermal cells	collagen type V	heparin binding|integrin binding|platelet-derived growth factor binding|proteoglycan binding			skin(4)|ovary(3)|pancreas(2)|central_nervous_system(1)|kidney(1)	11		Myeloproliferative disorder(178;0.0341)		all cancers(34;2.28e-08)|OV - Ovarian serous cystadenocarcinoma(145;6.03e-08)|Epithelial(140;6.4e-08)|GBM - Glioblastoma multiforme(294;0.131)		TGGGCATCAAGGGTGATCGGG	0.597													157	78	---	---	---	---	PASS
SNAPC4	6621	broad.mit.edu	37	9	139289762	139289762	+	Missense_Mutation	SNP	C	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr9:139289762C>G	uc004chh.2	-	4	468	c.459G>C	c.(457-459)AAG>AAC	p.K153N		NM_003086	NP_003077	Q5SXM2	SNPC4_HUMAN	small nuclear RNA activating complex,	153					snRNA transcription from RNA polymerase II promoter|snRNA transcription from RNA polymerase III promoter	snRNA-activating protein complex	DNA binding|sequence-specific DNA binding transcription factor activity				0		Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;5.31e-06)|Epithelial(140;7.13e-06)		CGCCCGTGACCTTGTCCTTGA	0.592													8	63	---	---	---	---	PASS
TAF3	83860	broad.mit.edu	37	10	7860771	7860771	+	Silent	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr10:7860771C>T	uc010qbd.1	+	1	99	c.99C>T	c.(97-99)CTC>CTT	p.L33L		NM_031923	NP_114129	Q5VWG9	TAF3_HUMAN	RNA polymerase II transcription factor TAFII140	33					maintenance of protein location in nucleus|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	transcription factor TFIID complex	protein binding|zinc ion binding			ovary(1)	1						CCTGCCACCTCCTCACGGACG	0.672													5	7	---	---	---	---	PASS
USP6NL	9712	broad.mit.edu	37	10	11504657	11504657	+	Missense_Mutation	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr10:11504657C>T	uc001ikt.3	-	15	2591	c.2270G>A	c.(2269-2271)AGC>AAC	p.S757N	USP6NL_uc001iks.1_Missense_Mutation_p.S774N	NM_014688	NP_055503	Q92738	US6NL_HUMAN	USP6 N-terminal like isoform 1	757						intracellular	Rab GTPase activator activity				0						ATTGCCACGGCTAGCATCTCG	0.468													85	127	---	---	---	---	PASS
ZWINT	11130	broad.mit.edu	37	10	58119839	58119839	+	Missense_Mutation	SNP	T	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr10:58119839T>C	uc001jjx.1	-	3	233	c.196A>G	c.(196-198)ATC>GTC	p.I66V	ZWINT_uc001jjy.1_Missense_Mutation_p.I66V|ZWINT_uc001jka.1_Missense_Mutation_p.I66V|ZWINT_uc009xoy.1_Intron	NM_007057	NP_008988	O95229	ZWINT_HUMAN	ZW10 interactor isoform a	66					cell division|establishment of localization in cell|mitotic cell cycle checkpoint|mitotic prometaphase|mitotic sister chromatid segregation|phosphatidylinositol-mediated signaling|spindle organization	condensed chromosome kinetochore|cytosol|nucleus	protein N-terminus binding				0						TGAGCCAGGATGTTCTGCAGG	0.557													26	41	---	---	---	---	PASS
CYP2C18	1562	broad.mit.edu	37	10	96495057	96495057	+	Missense_Mutation	SNP	G	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr10:96495057G>C	uc001kjv.3	+	9	1655	c.1329G>C	c.(1327-1329)ATG>ATC	p.M443I	CYP2C18_uc001kjw.3_Missense_Mutation_p.M384I|CYP2C19_uc009xus.1_Intron|CYP2C19_uc010qny.1_Intron	NM_000772	NP_000763	P33260	CP2CI_HUMAN	cytochrome P450 family 2 subfamily C polypeptide	443					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding|oxygen binding			ovary(3)|lung(1)|skin(1)	5		Colorectal(252;0.09)		all cancers(201;2.8e-06)|KIRC - Kidney renal clear cell carcinoma(50;0.0646)|Kidney(138;0.0805)		TGGCCCGCATGGAGCTGTTTT	0.443													52	66	---	---	---	---	PASS
SORCS1	114815	broad.mit.edu	37	10	108469059	108469059	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr10:108469059C>A	uc001kym.2	-	7	1073	c.1065G>T	c.(1063-1065)GAG>GAT	p.E355D	SORCS1_uc001kyl.2_Missense_Mutation_p.E355D|SORCS1_uc009xxs.2_Missense_Mutation_p.E355D|SORCS1_uc001kyn.1_Missense_Mutation_p.E355D|SORCS1_uc001kyo.2_Missense_Mutation_p.E355D	NM_052918	NP_443150	Q8WY21	SORC1_HUMAN	SORCS receptor 1 isoform a	355	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity|protein binding			breast(1)|central_nervous_system(1)	2		Breast(234;0.0256)|Colorectal(252;0.09)|Lung NSC(174;0.168)		Epithelial(162;1.66e-05)|all cancers(201;0.000689)		TCCTGTTGGCCTCTGTACAGT	0.373													9	51	---	---	---	---	PASS
MUC5B	727897	broad.mit.edu	37	11	1264226	1264226	+	Missense_Mutation	SNP	C	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr11:1264226C>G	uc009ycr.1	+	47	8321	c.8195C>G	c.(8194-8196)CCC>CGC	p.P2732R	MUC5B_uc001ltb.2_Missense_Mutation_p.P2042R	NM_017511	NP_059981	Q9HC84	MUC5B_HUMAN	SubName: Full=Mucin 5AC, oligomeric mucus/gel-forming;	2039	7 X Cys-rich subdomain repeats.|11 X approximate tandem repeats, Ser/Thr- rich.|Thr-rich.				cell adhesion	extracellular region	extracellular matrix structural constituent|protein binding				0		all_cancers(49;6.97e-08)|all_epithelial(84;3.45e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00141)|Lung(200;0.0853)|LUSC - Lung squamous cell carcinoma(625;0.1)		GTGGCCACCCCCTCCTCCACC	0.652													46	84	---	---	---	---	PASS
TRIM6-TRIM34	445372	broad.mit.edu	37	11	5664869	5664869	+	Missense_Mutation	SNP	A	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr11:5664869A>T	uc001mbf.2	+	14	2703	c.2459A>T	c.(2458-2460)CAG>CTG	p.Q820L	HBG2_uc001mak.1_Intron|TRIM34_uc001mbh.2_Missense_Mutation_p.Q466L|TRIM34_uc009yeq.2_Missense_Mutation_p.Q221L|TRIM34_uc001mbi.2_Missense_Mutation_p.Q466L|TRIM78P_uc009yer.2_Intron	NM_001003819	NP_001003819	B2RNG4	B2RNG4_HUMAN	tripartite motif-containing 6 and tripartite	820						intracellular	zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.00225)|Breast(177;0.0204)|all_neural(188;0.0212)		Epithelial(150;1.01e-08)|BRCA - Breast invasive adenocarcinoma(625;0.145)		TGCTTTTCTCAGCCTGTTTAT	0.423													92	258	---	---	---	---	PASS
CCKBR	887	broad.mit.edu	37	11	6291981	6291981	+	Silent	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr11:6291981C>T	uc001mcp.2	+	4	952	c.759C>T	c.(757-759)GGC>GGT	p.G253G	CCKBR_uc001mcq.2_Silent_p.G181G|CCKBR_uc001mcr.2_Silent_p.G253G|CCKBR_uc001mcs.2_Silent_p.G253G|CCKBR_uc001mct.1_5'Flank	NM_176875	NP_795344	P32239	GASR_HUMAN	cholecystokinin B receptor	253	Cytoplasmic (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|cell proliferation|digestion|elevation of cytosolic calcium ion concentration|feeding behavior|positive regulation of cell proliferation|sensory perception		1-phosphatidylinositol-3-kinase regulator activity|gastrin receptor activity|phosphatidylinositol phospholipase C activity|type B gastrin/cholecystokinin receptor binding			lung(5)|ovary(2)|breast(1)	8		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.029)		Epithelial(150;2.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.139)	Pentagastrin(DB00183)	GCTTTGACGGCGACAGTGACA	0.597													28	87	---	---	---	---	PASS
MUC15	143662	broad.mit.edu	37	11	26584686	26584686	+	Missense_Mutation	SNP	A	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr11:26584686A>T	uc001mqx.2	-	3	1087	c.821T>A	c.(820-822)CTT>CAT	p.L274H	ANO3_uc010rdr.1_Intron|ANO3_uc001mqt.3_Intron|ANO3_uc010rds.1_Intron|ANO3_uc010rdt.1_Intron|MUC15_uc001mqw.2_Missense_Mutation_p.L301H|MUC15_uc001mqy.2_Intron	NM_145650	NP_663625	Q8N387	MUC15_HUMAN	mucin 15 isoform b	274	Cytoplasmic (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						GTCGTCATAAAGTCGCCGATG	0.423													46	101	---	---	---	---	PASS
FIBIN	387758	broad.mit.edu	37	11	27016499	27016499	+	Silent	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr11:27016499C>T	uc001mrd.2	+	1	872	c.426C>T	c.(424-426)AGC>AGT	p.S142S		NM_203371	NP_976249	Q8TAL6	FIBIN_HUMAN	fin bud initiation factor homolog precursor	142						extracellular region|Golgi apparatus					0						AGCTGGAGAGCAAGTTCAAGC	0.592													39	63	---	---	---	---	PASS
OR10AG1	282770	broad.mit.edu	37	11	55735108	55735108	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr11:55735108G>T	uc010rit.1	-	1	832	c.832C>A	c.(832-834)CCT>ACT	p.P278T		NM_001005491	NP_001005491	Q8NH19	O10AG_HUMAN	olfactory receptor, family 10, subfamily AG,	278	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.0137)					TATATAATAGGATTCAAAGTT	0.343													33	56	---	---	---	---	PASS
OR5F1	338674	broad.mit.edu	37	11	55761176	55761176	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr11:55761176C>A	uc010riv.1	-	1	926	c.926G>T	c.(925-927)AGG>ATG	p.R309M		NM_003697	NP_003688	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F,	309	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					GGAAGAGGTCCTTTTCCTGCT	0.353													15	45	---	---	---	---	PASS
OR5M3	219482	broad.mit.edu	37	11	56237489	56237489	+	Missense_Mutation	SNP	T	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr11:56237489T>C	uc010rjk.1	-	1	485	c.485A>G	c.(484-486)TAC>TGC	p.Y162C		NM_001004742	NP_001004742	Q8NGP4	OR5M3_HUMAN	olfactory receptor, family 5, subfamily M,	162	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2	Esophageal squamous(21;0.00448)					GTACAAGCCGTAAGTCCATAA	0.403													5	185	---	---	---	---	PASS
OR9G4	283189	broad.mit.edu	37	11	56511019	56511019	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr11:56511019G>T	uc010rjo.1	-	1	269	c.269C>A	c.(268-270)TCT>TAT	p.S90Y		NM_001005284	NP_001005284	Q8NGQ1	OR9G4_HUMAN	olfactory receptor, family 9, subfamily G,	90	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						GGTATACACAGAGGTATACCA	0.433													38	116	---	---	---	---	PASS
SERPING1	710	broad.mit.edu	37	11	57373646	57373646	+	Silent	SNP	C	T	T	rs143760635	byFrequency	TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr11:57373646C>T	uc001nkp.1	+	5	1040	c.849C>T	c.(847-849)TCC>TCT	p.S283S	SERPING1_uc001nkq.1_Silent_p.S283S|SERPING1_uc010rju.1_Silent_p.S231S|SERPING1_uc010rjv.1_Silent_p.S288S|SERPING1_uc001nkr.1_Silent_p.S283S|SERPING1_uc009ymi.1_Silent_p.S283S|SERPING1_uc009ymj.1_Silent_p.S283S|SERPING1_uc001nks.1_5'UTR	NM_000062	NP_000053	P05155	IC1_HUMAN	serpin peptidase inhibitor, clade G, member 1	283					blood circulation|blood coagulation, intrinsic pathway|complement activation, classical pathway|innate immune response|negative regulation of complement activation, lectin pathway|platelet activation|platelet degranulation	extracellular space|platelet alpha granule lumen	protein binding|serine-type endopeptidase inhibitor activity			central_nervous_system(1)	1						GTCTGCCCTCCGATACCCGCC	0.542									Hereditary_Angioedema				13	166	---	---	---	---	PASS
MPEG1	219972	broad.mit.edu	37	11	58978608	58978608	+	Silent	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr11:58978608G>A	uc001nnu.3	-	1	1887	c.1731C>T	c.(1729-1731)TGC>TGT	p.C577C		NM_001039396	NP_001034485	Q2M385	MPEG1_HUMAN	macrophage expressed gene 1 precursor	577	Extracellular (Potential).					integral to membrane				ovary(1)|skin(1)	2		all_epithelial(135;0.125)				CGGATTTGACGCAATAGGACA	0.597													14	200	---	---	---	---	PASS
CD248	57124	broad.mit.edu	37	11	66082542	66082542	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr11:66082542G>T	uc001ohm.1	-	1	1974	c.1957C>A	c.(1957-1959)CCC>ACC	p.P653T		NM_020404	NP_065137	Q9HCU0	CD248_HUMAN	tumor endothelial marker 1 precursor	653	Pro-rich.|Extracellular (Potential).					integral to membrane|proteinaceous extracellular matrix	calcium ion binding|sugar binding			large_intestine(3)	3					Cefalotin(DB00456)	GCCAACTTGGGACTGGGGCCA	0.642													35	66	---	---	---	---	PASS
IGHMBP2	3508	broad.mit.edu	37	11	68707096	68707096	+	Missense_Mutation	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr11:68707096C>T	uc001ook.1	+	15	2981	c.2879C>T	c.(2878-2880)TCC>TTC	p.S960F	IGHMBP2_uc001ool.1_Missense_Mutation_p.S584F	NM_002180	NP_002171	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	960					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			AAGAACGGATCCCTGGACCCA	0.657													115	65	---	---	---	---	PASS
MYEOV	26579	broad.mit.edu	37	11	69063258	69063258	+	Missense_Mutation	SNP	G	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr11:69063258G>C	uc001oov.2	+	3	791	c.341G>C	c.(340-342)GGT>GCT	p.G114A	MYEOV_uc001oox.2_Intron|MYEOV_uc009ysl.2_Missense_Mutation_p.G114A|MYEOV_uc001oow.2_Missense_Mutation_p.G56A	NM_138768	NP_620123	Q96EZ4	MYEOV_HUMAN	myeloma overexpressed	114											0	all_lung(4;2.21e-19)|Lung NSC(4;6.13e-19)|Melanoma(5;0.00128)		LUSC - Lung squamous cell carcinoma(11;3.33e-11)|STAD - Stomach adenocarcinoma(18;0.00654)|LUAD - Lung adenocarcinoma(13;0.0713)	Kidney(183;2.99e-09)|KIRC - Kidney renal clear cell carcinoma(183;3.23e-08)|Lung(977;0.00361)|LUSC - Lung squamous cell carcinoma(976;0.0153)		GGAGACAAGGGTGCCCAGACA	0.617													13	898	---	---	---	---	PASS
MIR548K	100302272	broad.mit.edu	37	11	70130106	70130106	+	RNA	SNP	A	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr11:70130106A>G	hsa-mir-548k|MI0006354	+			c.46A>G			PPFIA1_uc001opn.1_Intron|PPFIA1_uc001opo.2_Intron|PPFIA1_uc001opp.2_Intron																	0						gtacttgcggattttgcttta	0.144													13	355	---	---	---	---	PASS
GRM5	2915	broad.mit.edu	37	11	88300727	88300727	+	Silent	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr11:88300727G>T	uc001pcq.2	-	7	2324	c.2124C>A	c.(2122-2124)ATC>ATA	p.I708I	GRM5_uc009yvm.2_Silent_p.I708I	NM_001143831	NP_001137303	P41594	GRM5_HUMAN	glutamate receptor, metabotropic 5 isoform a	708	Helical; Name=4; (Potential).				activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway|synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			central_nervous_system(4)|ovary(2)|lung(2)|breast(1)	9		Acute lymphoblastic leukemia(157;2.54e-05)|all_hematologic(158;0.00834)			Acamprosate(DB00659)	AGAGGGCAACGATGATGCCCA	0.463													37	52	---	---	---	---	PASS
UBASH3B	84959	broad.mit.edu	37	11	122669743	122669743	+	Splice_Site	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr11:122669743G>A	uc001pyi.3	+	10	1810	c.1450_splice	c.e10+1	p.G484_splice		NM_032873	NP_116262	Q8TF42	UBS3B_HUMAN	ubiquitin associated and SH3 domain containing,							cytoplasm|nucleus	protein tyrosine phosphatase activity			central_nervous_system(1)	1		Breast(109;0.00254)|Medulloblastoma(222;0.00877)|Lung NSC(97;0.0183)|all_lung(97;0.0186)|all_neural(223;0.0381)|all_hematologic(192;0.104)		BRCA - Breast invasive adenocarcinoma(274;1.37e-05)|OV - Ovarian serous cystadenocarcinoma(99;0.0463)		ATCTTGAAAGGTAAGACTTGC	0.443													14	32	---	---	---	---	PASS
OR6X1	390260	broad.mit.edu	37	11	123624792	123624792	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr11:123624792G>T	uc010rzy.1	-	1	435	c.435C>A	c.(433-435)AGC>AGA	p.S145R		NM_001005188	NP_001005188	Q8NH79	OR6X1_HUMAN	olfactory receptor, family 6, subfamily X,	145	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3		Breast(109;0.0109)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0279)		CCACCCAGGAGCTCAGGGCCA	0.507													19	43	---	---	---	---	PASS
OR8B8	26493	broad.mit.edu	37	11	124310747	124310747	+	Missense_Mutation	SNP	G	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr11:124310747G>C	uc010sal.1	-	1	235	c.235C>G	c.(235-237)CCC>GCC	p.P79A		NM_012378	NP_036510	Q15620	OR8B8_HUMAN	olfactory receptor, family 8, subfamily B,	79	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		AGCATTTTGGGAGTGATAACA	0.418													26	36	---	---	---	---	PASS
EFCAB4B	84766	broad.mit.edu	37	12	3806114	3806114	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr12:3806114C>A	uc001qmj.2	-	4	624	c.52G>T	c.(52-54)GGG>TGG	p.G18W	EFCAB4B_uc010sen.1_Missense_Mutation_p.G18W|EFCAB4B_uc010seo.1_Missense_Mutation_p.G18W	NM_032680	NP_116069	Q9BSW2	EFC4B_HUMAN	EF-hand calcium binding domain 4B isoform c	18					activation of store-operated calcium channel activity|store-operated calcium entry	cytoplasm	calcium ion binding|protein binding			ovary(1)|pancreas(1)	2			OV - Ovarian serous cystadenocarcinoma(31;0.00287)|COAD - Colon adenocarcinoma(12;0.0264)			TGGCCAGACCCCTGACCAAGT	0.572													12	23	---	---	---	---	PASS
SLCO1B1	10599	broad.mit.edu	37	12	21355459	21355459	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr12:21355459G>T	uc001req.3	+	10	1274	c.1170G>T	c.(1168-1170)ATG>ATT	p.M390I		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,	390	Helical; Name=8; (Potential).				bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	CAAGTGGAATGTTTTTAGGAG	0.299													12	37	---	---	---	---	PASS
LRRK2	120892	broad.mit.edu	37	12	40749984	40749984	+	Missense_Mutation	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr12:40749984G>A	uc001rmg.3	+	46	6959	c.6838G>A	c.(6838-6840)GTT>ATT	p.V2280I	LRRK2_uc009zjw.2_Missense_Mutation_p.V1118I|LRRK2_uc001rmi.2_Missense_Mutation_p.V1113I	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	2280					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				AGATAAGACTGTTAAGGTAAA	0.204													9	27	---	---	---	---	PASS
PUS7L	83448	broad.mit.edu	37	12	44124214	44124214	+	Missense_Mutation	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr12:44124214C>T	uc001rnq.3	-	9	2560	c.2071G>A	c.(2071-2073)GTT>ATT	p.V691I	PUS7L_uc001rnr.3_Missense_Mutation_p.V691I|PUS7L_uc001rns.3_Missense_Mutation_p.V691I|PUS7L_uc009zkb.2_Missense_Mutation_p.V378I	NM_001098615	NP_001092085	Q9H0K6	PUS7L_HUMAN	pseudouridylate synthase 7 homolog (S.	691					pseudouridine synthesis|tRNA processing		pseudouridine synthase activity|RNA binding			pancreas(1)	1	all_cancers(12;0.00027)	Lung NSC(34;0.114)|all_lung(34;0.24)		GBM - Glioblastoma multiforme(48;0.0402)		TTCAGACAAACGGTAGCATAG	0.353													21	36	---	---	---	---	PASS
NCKAP1L	3071	broad.mit.edu	37	12	54901665	54901665	+	Missense_Mutation	SNP	T	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr12:54901665T>G	uc001sgc.3	+	4	414	c.335T>G	c.(334-336)ATT>AGT	p.I112S	NCKAP1L_uc010sox.1_5'UTR|NCKAP1L_uc010soy.1_Missense_Mutation_p.I62S	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	112					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						CTCAACACCATTGATGCCTGC	0.423													58	126	---	---	---	---	PASS
NEUROD4	58158	broad.mit.edu	37	12	55420899	55420899	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr12:55420899C>A	uc001sgp.3	+	2	1054	c.676C>A	c.(676-678)CCC>ACC	p.P226T		NM_021191	NP_067014	Q9HD90	NDF4_HUMAN	neurogenic differentiation 4	226					amacrine cell differentiation|positive regulation of cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(3)|skin(1)	4						TCATCTCAAGCCCCAAGTATT	0.517													42	99	---	---	---	---	PASS
OR6C75	390323	broad.mit.edu	37	12	55759054	55759054	+	Missense_Mutation	SNP	C	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr12:55759054C>G	uc010spk.1	+	1	160	c.160C>G	c.(160-162)CAG>GAG	p.Q54E		NM_001005497	NP_001005497	A6NL08	O6C75_HUMAN	olfactory receptor, family 6, subfamily C,	54	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|large_intestine(1)	3						TCCCCATCTGCAGACTCCCAT	0.433													59	166	---	---	---	---	PASS
STAB2	55576	broad.mit.edu	37	12	104054499	104054499	+	Silent	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr12:104054499G>A	uc001tjw.2	+	17	2013	c.1827G>A	c.(1825-1827)AGG>AGA	p.R609R		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	609	Extracellular (Potential).|FAS1 2.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						CTCACATCAGGAGCATGGCCA	0.483													31	112	---	---	---	---	PASS
DDX54	79039	broad.mit.edu	37	12	113603449	113603449	+	Silent	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr12:113603449C>A	uc001tup.2	-	14	1747	c.1719G>T	c.(1717-1719)GCG>GCT	p.A573A	DDX54_uc001tuq.3_Silent_p.A573A	NM_024072	NP_076977	Q8TDD1	DDX54_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 54	573					estrogen receptor signaling pathway|regulation of transcription, DNA-dependent|RNA processing|transcription, DNA-dependent	nucleolus	ATP binding|ATP-dependent RNA helicase activity|estrogen receptor binding|RNA binding|transcription corepressor activity			skin(2)|central_nervous_system(1)	3						CCCCACTCACCGCCCGGGAGC	0.458													9	17	---	---	---	---	PASS
COQ5	84274	broad.mit.edu	37	12	120960138	120960138	+	Silent	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr12:120960138C>T	uc001tyn.2	-	2	251	c.231G>A	c.(229-231)AAG>AAA	p.K77K	COQ5_uc001tyo.2_5'UTR|COQ5_uc010szj.1_Silent_p.K77K	NM_032314	NP_115690	Q5HYK3	COQ5_HUMAN	coenzyme Q5 homolog, methyltransferase	77					ubiquinone biosynthetic process	mitochondrion	methyltransferase activity			ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CATCATACTTCTTAGCCACAC	0.423													16	106	---	---	---	---	PASS
MTUS2	23281	broad.mit.edu	37	13	29855875	29855875	+	Silent	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr13:29855875G>A	uc001usl.3	+	4	2767	c.2709G>A	c.(2707-2709)CTG>CTA	p.L903L		NM_001033602	NP_001028774	Q5JR59	MTUS2_HUMAN	hypothetical protein LOC23281 isoform a	893	Localization to the growing distal tip of microtubules.|Mediates interaction with MAPRE1.					cytoplasm|microtubule	microtubule binding|protein homodimerization activity				0						AGCCAGTTCTGAAGGCATCTC	0.542													22	12	---	---	---	---	PASS
STARD13	90627	broad.mit.edu	37	13	33704302	33704302	+	Missense_Mutation	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr13:33704302G>A	uc001uuw.2	-	5	638	c.512C>T	c.(511-513)TCA>TTA	p.S171L	STARD13_uc001uuu.2_Missense_Mutation_p.S163L|STARD13_uc001uuv.2_Missense_Mutation_p.S53L|STARD13_uc001uux.2_Missense_Mutation_p.S136L|STARD13_uc010tec.1_RNA|STARD13_uc010abh.1_Missense_Mutation_p.S156L	NM_178006	NP_821074	Q9Y3M8	STA13_HUMAN	StAR-related lipid transfer (START) domain	171					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|lipid particle|mitochondrial membrane	GTPase activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4	all_epithelial(80;0.155)	Lung SC(185;0.0367)		all cancers(112;1.31e-05)|Epithelial(112;0.000142)|BRCA - Breast invasive adenocarcinoma(63;0.00936)|OV - Ovarian serous cystadenocarcinoma(117;0.0533)|Lung(94;0.143)|GBM - Glioblastoma multiforme(144;0.143)		GCCTCCCGGTGACCCATTTCT	0.567													5	37	---	---	---	---	PASS
NBEA	26960	broad.mit.edu	37	13	35923291	35923291	+	Nonsense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr13:35923291G>T	uc001uvb.2	+	37	6156	c.5950G>T	c.(5950-5952)GAA>TAA	p.E1984*	NBEA_uc010abi.2_Nonsense_Mutation_p.E640*	NM_015678	NP_056493	Q8NFP9	NBEA_HUMAN	neurobeachin	1984						cytosol|endomembrane system|plasma membrane|trans-Golgi network	protein binding			ovary(9)|large_intestine(2)	11		Breast(139;0.0141)|Lung SC(185;0.0548)|Prostate(109;0.207)		all cancers(112;1.93e-08)|Epithelial(112;1.62e-07)|BRCA - Breast invasive adenocarcinoma(63;0.00033)|OV - Ovarian serous cystadenocarcinoma(117;0.00109)|KIRC - Kidney renal clear cell carcinoma(186;0.00575)|Kidney(163;0.00656)|GBM - Glioblastoma multiforme(144;0.191)|Lung(94;0.199)		TGTTGCAAATGAAGCTGAGTT	0.358													42	33	---	---	---	---	PASS
OR4Q3	441669	broad.mit.edu	37	14	20216282	20216282	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr14:20216282G>T	uc010tkt.1	+	1	696	c.696G>T	c.(694-696)CAG>CAT	p.Q232H		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	232	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		ACTTCTGCCAGGGCCAGAACA	0.488													45	125	---	---	---	---	PASS
OR4N2	390429	broad.mit.edu	37	14	20296286	20296286	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr14:20296286G>T	uc010tkv.1	+	1	679	c.679G>T	c.(679-681)GGG>TGG	p.G227W		NM_001004723	NP_001004723	Q8NGD1	OR4N2_HUMAN	olfactory receptor, family 4, subfamily N,	227	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|central_nervous_system(1)|skin(1)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCGCATACGAGGGTCTTCTTC	0.488													38	109	---	---	---	---	PASS
ACTN1	87	broad.mit.edu	37	14	69346758	69346758	+	Missense_Mutation	SNP	T	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr14:69346758T>C	uc001xkl.2	-	18	2511	c.2201A>G	c.(2200-2202)CAG>CGG	p.Q734R	ACTN1_uc001xkk.2_Missense_Mutation_p.Q330R|ACTN1_uc010ttb.1_Missense_Mutation_p.Q669R|ACTN1_uc001xkm.2_Missense_Mutation_p.Q734R|ACTN1_uc001xkn.2_Missense_Mutation_p.Q734R|ACTN1_uc010ttc.1_Missense_Mutation_p.Q319R	NM_001102	NP_001093	P12814	ACTN1_HUMAN	actinin, alpha 1 isoform b	734					focal adhesion assembly|negative regulation of cellular component movement|platelet activation|platelet degranulation|regulation of apoptosis	actin cytoskeleton|cytosol|extracellular region|focal adhesion|nucleolus|platelet alpha granule lumen|pseudopodium|sarcomere	actin binding|calcium ion binding|integrin binding|vinculin binding			central_nervous_system(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00605)|all cancers(60;0.00846)|OV - Ovarian serous cystadenocarcinoma(108;0.0654)		GGTCAGGATCTGGTTCTCTAC	0.607													16	69	---	---	---	---	PASS
ADAM20	8748	broad.mit.edu	37	14	70990703	70990703	+	Missense_Mutation	SNP	C	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr14:70990703C>G	uc001xme.2	-	2	1167	c.922G>C	c.(922-924)GAT>CAT	p.D308H		NM_003814	NP_003805	O43506	ADA20_HUMAN	ADAM metallopeptidase domain 20 preproprotein	258	Peptidase M12B.|Extracellular (Potential).				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		GTCCATATATCAATTCCAGTC	0.348													31	61	---	---	---	---	PASS
YLPM1	56252	broad.mit.edu	37	14	75269278	75269278	+	Missense_Mutation	SNP	C	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr14:75269278C>G	uc001xqj.3	+	6	4544	c.4420C>G	c.(4420-4422)CAA>GAA	p.Q1474E	YLPM1_uc001xql.3_RNA	NM_019589	NP_062535	P49750	YLPM1_HUMAN	YLP motif containing 1	1279					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nuclear speck				ovary(2)|pancreas(1)	3			KIRC - Kidney renal clear cell carcinoma(43;0.238)	BRCA - Breast invasive adenocarcinoma(234;0.00162)		AGAACAGCTTCAAAAGATGAA	0.368													6	91	---	---	---	---	PASS
VRK1	7443	broad.mit.edu	37	14	97312478	97312478	+	Missense_Mutation	SNP	A	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr14:97312478A>T	uc001yft.2	+	4	369	c.263A>T	c.(262-264)CAA>CTA	p.Q88L		NM_003384	NP_003375	Q99986	VRK1_HUMAN	vaccinia related kinase 1	88	Protein kinase.					cytoplasm|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity			large_intestine(1)|stomach(1)	2		Melanoma(154;0.155)		COAD - Colon adenocarcinoma(157;0.234)		AAGTTCTACCAACGAGCTGCA	0.328													57	96	---	---	---	---	PASS
ATP10A	57194	broad.mit.edu	37	15	25959388	25959388	+	Missense_Mutation	SNP	C	A	A	rs114091283	byFrequency	TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr15:25959388C>A	uc010ayu.2	-	10	1883	c.1777G>T	c.(1777-1779)GTG>TTG	p.V593L		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	593	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		CTCACCCTCACCTGCAAGAGA	0.587													19	35	---	---	---	---	PASS
TGM5	9333	broad.mit.edu	37	15	43525446	43525446	+	Missense_Mutation	SNP	G	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr15:43525446G>C	uc001zrd.1	-	13	2114	c.2106C>G	c.(2104-2106)AGC>AGG	p.S702R	TGM5_uc001zrc.1_Missense_Mutation_p.S359R|TGM5_uc001zre.1_Missense_Mutation_p.S620R	NM_201631	NP_963925	O43548	TGM5_HUMAN	transglutaminase 5 isoform 1	702					epidermis development|peptide cross-linking	cytoplasm	acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			central_nervous_system(1)	1		all_cancers(109;1.37e-14)|all_epithelial(112;1.26e-12)|Lung NSC(122;2.46e-08)|all_lung(180;2.75e-07)|Melanoma(134;0.0476)|Colorectal(260;0.216)		GBM - Glioblastoma multiforme(94;4e-07)	L-Glutamine(DB00130)	TAAACTTGTTGCTTCTCATAT	0.448													16	34	---	---	---	---	PASS
SEMA6D	80031	broad.mit.edu	37	15	48056400	48056400	+	Missense_Mutation	SNP	G	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr15:48056400G>C	uc010bek.2	+	11	1355	c.995G>C	c.(994-996)AGC>ACC	p.S332T	SEMA6D_uc001zvw.2_Missense_Mutation_p.S332T|SEMA6D_uc001zvx.1_Missense_Mutation_p.S332T|SEMA6D_uc001zvy.2_Missense_Mutation_p.S332T|SEMA6D_uc001zvz.2_Missense_Mutation_p.S332T|SEMA6D_uc001zwa.2_Missense_Mutation_p.S332T|SEMA6D_uc001zwb.2_Missense_Mutation_p.S332T|SEMA6D_uc001zwc.2_Missense_Mutation_p.S332T	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	332	Sema.|Extracellular (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		TGTGCATTTAGCATGGATGAC	0.458													13	130	---	---	---	---	PASS
GNB5	10681	broad.mit.edu	37	15	52420404	52420404	+	Missense_Mutation	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr15:52420404C>T	uc002abt.1	-	10	966	c.901G>A	c.(901-903)GAT>AAT	p.D301N	GNB5_uc002abr.1_Missense_Mutation_p.D259N|GNB5_uc002abs.1_Missense_Mutation_p.D189N	NM_016194	NP_057278	O14775	GBB5_HUMAN	guanine nucleotide-binding protein, beta-5	301	WD 5.					heterotrimeric G-protein complex	GTPase activity|signal transducer activity			lung(1)	1				all cancers(107;0.0163)		GTAGCGTCATCTGACCCTGAA	0.423													5	60	---	---	---	---	PASS
PRTG	283659	broad.mit.edu	37	15	55932011	55932011	+	Missense_Mutation	SNP	A	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr15:55932011A>T	uc002adg.2	-	13	2201	c.2153T>A	c.(2152-2154)ATG>AAG	p.M718K		NM_173814	NP_776175	Q2VWP7	PRTG_HUMAN	protogenin precursor	718					multicellular organismal development	integral to membrane				large_intestine(1)|ovary(1)|skin(1)	3				all cancers(107;0.00891)|GBM - Glioblastoma multiforme(80;0.135)		AGGAGGGACCATGCGATCACG	0.433													35	45	---	---	---	---	PASS
TEX9	374618	broad.mit.edu	37	15	56680680	56680680	+	Missense_Mutation	SNP	C	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr15:56680680C>G	uc002adp.2	+	5	279	c.274C>G	c.(274-276)CCA>GCA	p.P92A	TEX9_uc002ado.1_Missense_Mutation_p.P92A|TEX9_uc010ugl.1_Missense_Mutation_p.P17A|TEX9_uc002adq.1_Missense_Mutation_p.P17A	NM_198524	NP_940926	Q8N6V9	TEX9_HUMAN	testis expressed 9	92											0				all cancers(107;0.0394)|GBM - Glioblastoma multiforme(80;0.056)		AGGTCTGTTACCATCTGAAGG	0.308													10	94	---	---	---	---	PASS
SPESP1	246777	broad.mit.edu	37	15	69238793	69238793	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr15:69238793G>T	uc002arn.1	+	2	1048	c.920G>T	c.(919-921)AGA>ATA	p.R307I	NOX5_uc002arp.1_Intron|NOX5_uc002arq.1_Intron|NOX5_uc010bid.1_Intron|NOX5_uc002aro.2_Intron	NM_145658	NP_663633	Q6UW49	SPESP_HUMAN	sperm equatorial segment protein 1 precursor	307					multicellular organismal development	acrosomal vesicle					0						TGTAATTCTAGATCTAAACTC	0.294													23	70	---	---	---	---	PASS
ADAMTS7	11173	broad.mit.edu	37	15	79051886	79051886	+	Silent	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr15:79051886G>A	uc002bej.3	-	24	5149	c.4938C>T	c.(4936-4938)TGC>TGT	p.C1646C		NM_014272	NP_055087	Q9UKP4	ATS7_HUMAN	ADAM metallopeptidase with thrombospondin type 1	1646	PLAC.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0						GCAGCGTCTCGCAGAACCCGA	0.701													3	20	---	---	---	---	PASS
SLC28A1	9154	broad.mit.edu	37	15	85438313	85438313	+	Silent	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr15:85438313C>T	uc002blg.2	+	6	622	c.420C>T	c.(418-420)CTC>CTT	p.L140L	SLC28A1_uc010upd.1_Silent_p.L62L|SLC28A1_uc010bnb.2_Silent_p.L140L|SLC28A1_uc010upe.1_Silent_p.L140L|SLC28A1_uc010upf.1_Silent_p.L140L|SLC28A1_uc010upg.1_Silent_p.L140L|SLC28A1_uc002blf.2_Silent_p.L140L	NM_004213	NP_004204	O00337	S28A1_HUMAN	solute carrier family 28, member 1 isoform 1	140			L -> LV (in A).		nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GGAGGTTTCTCAAGCCTCAGG	0.637													13	60	---	---	---	---	PASS
SLC28A1	9154	broad.mit.edu	37	15	85438320	85438320	+	Nonsense_Mutation	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr15:85438320C>T	uc002blg.2	+	6	629	c.427C>T	c.(427-429)CAG>TAG	p.Q143*	SLC28A1_uc010upd.1_Nonsense_Mutation_p.Q65*|SLC28A1_uc010bnb.2_Nonsense_Mutation_p.Q143*|SLC28A1_uc010upe.1_Nonsense_Mutation_p.Q143*|SLC28A1_uc010upf.1_Nonsense_Mutation_p.Q143*|SLC28A1_uc010upg.1_Nonsense_Mutation_p.Q143*|SLC28A1_uc002blf.2_Nonsense_Mutation_p.Q143*	NM_004213	NP_004204	O00337	S28A1_HUMAN	solute carrier family 28, member 1 isoform 1	143					nucleobase, nucleoside and nucleotide metabolic process	integral to plasma membrane|membrane fraction	nucleoside binding			skin(2)|ovary(1)	3			BRCA - Breast invasive adenocarcinoma(143;0.0587)			TCTCAAGCCTCAGGGCCATCC	0.637													13	59	---	---	---	---	PASS
HN1L	90861	broad.mit.edu	37	16	1748833	1748833	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr16:1748833G>T	uc002cmg.2	+	5	443	c.407G>T	c.(406-408)GGA>GTA	p.G136V	HN1L_uc010uvi.1_Missense_Mutation_p.G164V|HN1L_uc010brt.2_RNA|HN1L_uc010bru.2_3'UTR|HN1L_uc010uvj.1_3'UTR|HN1L_uc010uvk.1_Missense_Mutation_p.G123V	NM_144570	NP_653171	Q9H910	HN1L_HUMAN	hematological and neurological expressed 1-like	136						cytoplasm|nucleus				upper_aerodigestive_tract(1)	1						ATCCCGGCTGGAGCAGAGCCA	0.597													12	38	---	---	---	---	PASS
RPL3L	6123	broad.mit.edu	37	16	1997365	1997365	+	Missense_Mutation	SNP	A	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr16:1997365A>G	uc002cnh.2	-	5	565	c.518T>C	c.(517-519)TTC>TCC	p.F173S		NM_005061	NP_005052	Q92901	RL3L_HUMAN	ribosomal protein L3-like	173					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosol|ribosome	RNA binding|structural constituent of ribosome				0						CTTCTGCCGGAAGGGCAGCAG	0.657													6	17	---	---	---	---	PASS
GRIN2A	2903	broad.mit.edu	37	16	9862767	9862767	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr16:9862767G>T	uc002czo.3	-	12	3084	c.2536C>A	c.(2536-2538)CGC>AGC	p.R846S	GRIN2A_uc010uym.1_Missense_Mutation_p.R846S|GRIN2A_uc010uyn.1_Missense_Mutation_p.R689S|GRIN2A_uc002czr.3_Missense_Mutation_p.R846S	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	846	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	AAACAGAAGCGCAGCTTCCAG	0.582													21	78	---	---	---	---	PASS
GP2	2813	broad.mit.edu	37	16	20334224	20334224	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr16:20334224C>A	uc002dgv.2	-	5	705	c.622G>T	c.(622-624)GGC>TGC	p.G208C	GP2_uc002dgw.2_Missense_Mutation_p.G205C|GP2_uc002dgx.2_Missense_Mutation_p.G61C|GP2_uc002dgy.2_Missense_Mutation_p.G58C	NM_001007240	NP_001007241	P55259	GP2_HUMAN	zymogen granule membrane glycoprotein 2 isoform	208	EGF-like.					anchored to membrane|extracellular region|plasma membrane				ovary(3)|skin(1)	4						CAGAAACAGCCCCAGGTGCTG	0.592													18	50	---	---	---	---	PASS
ACSM2A	123876	broad.mit.edu	37	16	20480940	20480940	+	Silent	SNP	A	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr16:20480940A>G	uc010bwe.2	+	5	734	c.495A>G	c.(493-495)CAA>CAG	p.Q165Q	ACSM2A_uc010bwd.1_RNA|ACSM2A_uc010vax.1_Silent_p.Q86Q|ACSM2A_uc002dhf.3_Silent_p.Q165Q|ACSM2A_uc002dhg.3_Silent_p.Q165Q|ACSM2A_uc010vay.1_Silent_p.Q86Q	NM_001010845	NP_001010845	Q08AH3	ACS2A_HUMAN	acyl-CoA synthetase medium-chain family member	165					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			skin(2)|breast(1)	3						AAGTCATCCAAGAAGTGGACA	0.443													48	100	---	---	---	---	PASS
ERN2	10595	broad.mit.edu	37	16	23713476	23713476	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr16:23713476C>A	uc002dma.3	-	11	1513	c.1344G>T	c.(1342-1344)TTG>TTT	p.L448F	ERN2_uc010bxp.2_Missense_Mutation_p.L448F|ERN2_uc010bxq.1_Missense_Mutation_p.L256F	NM_033266	NP_150296	Q76MJ5	ERN2_HUMAN	endoplasmic reticulum to nucleus signalling 2	400	Lumenal (Potential).				apoptosis|induction of apoptosis|mRNA processing|negative regulation of transcription, DNA-dependent|rRNA catabolic process|transcription, DNA-dependent	endoplasmic reticulum membrane|integral to membrane	ATP binding|endoribonuclease activity, producing 5'-phosphomonoesters|magnesium ion binding|protein serine/threonine kinase activity			large_intestine(2)|lung(2)|ovary(2)	6				GBM - Glioblastoma multiforme(48;0.0156)		CACTGACCTCCAAGAAGAAGG	0.592													20	58	---	---	---	---	PASS
SLC5A11	115584	broad.mit.edu	37	16	24921722	24921722	+	Silent	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr16:24921722C>T	uc002dmu.2	+	15	1978	c.1746C>T	c.(1744-1746)AAC>AAT	p.N582N	SLC5A11_uc002dms.2_Silent_p.N518N|SLC5A11_uc010vcd.1_Silent_p.N547N|SLC5A11_uc002dmt.2_Silent_p.N426N|SLC5A11_uc010vce.1_Silent_p.N512N|SLC5A11_uc010bxt.2_Silent_p.N518N|SLC5A11_uc002dmv.2_Silent_p.N205N	NM_052944	NP_443176	Q8WWX8	SC5AB_HUMAN	solute carrier family 5 (sodium/glucose	582	Cytoplasmic (Potential).				apoptosis|carbohydrate transport|sodium ion transport	integral to membrane|plasma membrane	polyol transmembrane transporter activity|symporter activity			ovary(2)	2				GBM - Glioblastoma multiforme(48;0.0365)		TCTCTCAGAACGGGATGCCAG	0.547													15	58	---	---	---	---	PASS
MYLK3	91807	broad.mit.edu	37	16	46771994	46771994	+	Silent	SNP	T	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr16:46771994T>A	uc002eei.3	-	3	746	c.630A>T	c.(628-630)TCA>TCT	p.S210S	MYLK3_uc010vge.1_Intron|MYLK3_uc002eej.1_5'UTR	NM_182493	NP_872299	Q32MK0	MYLK3_HUMAN	myosin light chain kinase 3	210					cardiac myofibril assembly|cellular response to interleukin-1|positive regulation of sarcomere organization|regulation of vascular permeability involved in acute inflammatory response|sarcomere organization|sarcomerogenesis	cytosol	ATP binding|calmodulin-dependent protein kinase activity|myosin light chain kinase activity			stomach(2)|skin(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	7		all_cancers(37;0.00023)|all_epithelial(9;0.000543)|all_lung(18;0.00585)|Lung NSC(13;0.0496)|Breast(268;0.116)				CTCCCAGCCCTGACGCTCTGA	0.657													6	12	---	---	---	---	PASS
ABCC11	85320	broad.mit.edu	37	16	48201277	48201277	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr16:48201277C>A	uc002eff.1	-	29	4407	c.4057G>T	c.(4057-4059)GTG>TTG	p.V1353L	ABCC11_uc002efg.1_Missense_Mutation_p.V1353L|ABCC11_uc002efh.1_Missense_Mutation_p.V1315L|ABCC11_uc010cbg.1_RNA	NM_033151	NP_149163	Q96J66	ABCCB_HUMAN	ATP-binding cassette, sub-family C, member 11	1353	ABC transporter 2.|Cytoplasmic (Potential).					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(3)|skin(2)|central_nervous_system(1)	6		all_cancers(37;0.127)|all_lung(18;0.132)|Breast(268;0.166)				AATTCTACCACCTGGAGGGTA	0.567									Cerumen_Type				7	44	---	---	---	---	PASS
N4BP1	9683	broad.mit.edu	37	16	48576971	48576971	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr16:48576971C>A	uc002efp.2	-	7	2772	c.2535G>T	c.(2533-2535)ATG>ATT	p.M845I		NM_153029	NP_694574	O75113	N4BP1_HUMAN	Nedd4 binding protein 1	845					negative regulation of proteasomal ubiquitin-dependent protein catabolic process|negative regulation of protein ubiquitination	nucleolus|PML body					0		all_cancers(37;0.179)|all_lung(18;0.11)				TCTGAGCTGGCATGGGCAGGT	0.577													10	47	---	---	---	---	PASS
GPR97	222487	broad.mit.edu	37	16	57719655	57719655	+	Missense_Mutation	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr16:57719655G>A	uc002emh.2	+	11	1460	c.1357G>A	c.(1357-1359)GTG>ATG	p.V453M	GPR97_uc010vhv.1_Missense_Mutation_p.V333M|GPR97_uc010cdd.2_RNA|GPR97_uc010cde.2_Missense_Mutation_p.V61M	NM_170776	NP_740746	Q86Y34	GPR97_HUMAN	G protein-coupled receptor 97 precursor	453	Helical; Name=5; (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)	1						CCTGGCCCTGGTGGTCTGGAA	0.592													14	50	---	---	---	---	PASS
CA7	766	broad.mit.edu	37	16	66887337	66887337	+	Missense_Mutation	SNP	T	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr16:66887337T>A	uc002eqi.2	+	7	840	c.731T>A	c.(730-732)GTG>GAG	p.V244E	uc002eqh.2_RNA|CA7_uc002eqj.2_Missense_Mutation_p.V188E	NM_005182	NP_005173	P43166	CAH7_HUMAN	carbonic anhydrase VII isoform 1	244					one-carbon metabolic process	cytoplasm	carbonate dehydratase activity|zinc ion binding				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.088)|Epithelial(162;0.204)		ATCCACATGGTGAACAACTTC	0.602													16	48	---	---	---	---	PASS
CLEC3A	10143	broad.mit.edu	37	16	78064718	78064718	+	Missense_Mutation	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr16:78064718G>A	uc002ffh.3	+	3	655	c.574G>A	c.(574-576)GAG>AAG	p.E192K		NM_005752	NP_005743	O75596	CLC3A_HUMAN	C-type lectin domain family 3 member A	192	C-type lectin.				skeletal system development	extracellular region	sugar binding				0						ATACATATGCGAGTTCACCAT	0.453													4	76	---	---	---	---	PASS
TP53	7157	broad.mit.edu	37	17	7579311	7579311	+	Splice_Site	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr17:7579311C>A	uc002gim.2	-	4	569	c.375_splice	c.e4+1	p.T125_splice	TP53_uc002gig.1_Splice_Site_p.T125_splice|TP53_uc002gih.2_Splice_Site_p.T125_splice|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Splice_Site_p.T125_splice|TP53_uc010cni.1_Splice_Site_p.T125_splice|TP53_uc002gij.2_Splice_Site_p.T125_splice|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Splice_Site_p.T86_splice	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a						activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.?(11)|p.0?(7)|p.V73fs*9(1)|p.Y126fs*11(1)|p.P13fs*18(1)|p.T125_Y126insX(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GGGCAACTGACCGTGCAAGTC	0.532		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			44	48	---	---	---	---	PASS
DNAH2	146754	broad.mit.edu	37	17	7696018	7696018	+	Missense_Mutation	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr17:7696018C>T	uc002giu.1	+	46	7203	c.7189C>T	c.(7189-7191)CGC>TGC	p.R2397C		NM_020877	NP_065928	Q9P225	DYH2_HUMAN	dynein heavy chain domain 3	2397	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(6)|skin(6)|central_nervous_system(1)	13		all_cancers(10;4.66e-07)|Prostate(122;0.081)				CGACACTGTTCGCTACAACTA	0.607													3	45	---	---	---	---	PASS
TMEM107	84314	broad.mit.edu	37	17	8079345	8079345	+	Splice_Site	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr17:8079345C>A	uc002gkg.3	-	2	198	c.88_splice	c.e2-1	p.D30_splice	TMEM107_uc002gkh.3_Splice_Site_p.D30_splice|TMEM107_uc002gki.3_Splice_Site_p.D30_splice|TMEM107_uc002gkj.3_Intron|TMEM107_uc002gkk.2_Splice_Site_p.D30_splice	NM_183065	NP_898888	Q6UX40	TM107_HUMAN	transmembrane protein 107 isoform 2							integral to membrane					0						TGTTGCTGTCCTGGGAGCAGG	0.597													38	34	---	---	---	---	PASS
MYH13	8735	broad.mit.edu	37	17	10235418	10235418	+	Nonsense_Mutation	SNP	T	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr17:10235418T>A	uc002gmk.1	-	20	2386	c.2296A>T	c.(2296-2298)AAG>TAG	p.K766*		NM_003802	NP_003793	Q9UKX3	MYH13_HUMAN	myosin, heavy polypeptide 13, skeletal muscle	766	Myosin head-like.|Actin-binding (By similarity).				muscle contraction	muscle myosin complex|myofibril|myosin filament	actin binding|ATP binding|calmodulin binding|microfilament motor activity			ovary(4)|skin(2)	6						GTGCTCACCTTGGTGTTGCCG	0.547													32	28	---	---	---	---	PASS
C17orf79	55352	broad.mit.edu	37	17	30179203	30179203	+	Silent	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr17:30179203G>A	uc002hgp.2	-	4	618	c.510C>T	c.(508-510)TCC>TCT	p.S170S	C17orf79_uc010css.2_RNA	NM_018405	NP_060875	Q9NQ92	COPR5_HUMAN	chromosome 17 open reading frame 79	170					histone H4-R3 methylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	histone binding				0		all_cancers(10;4.54e-07)|all_hematologic(16;0.0216)|Acute lymphoblastic leukemia(14;0.0255)|Myeloproliferative disorder(56;0.0393)|Ovarian(249;0.1)				AGACCATCTTGGAATAATAGG	0.502													41	38	---	---	---	---	PASS
KRTAP1-5	83895	broad.mit.edu	37	17	39183145	39183145	+	Missense_Mutation	SNP	A	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr17:39183145A>G	uc002hvu.2	-	1	310	c.263T>C	c.(262-264)ATC>ACC	p.I88T		NM_031957	NP_114163	Q9BYS1	KRA15_HUMAN	keratin associated protein 1.5	88	15 X 5 AA repeats of C-C-[QEPVRC]- [TPIVLE]-[SRHVP].					keratin filament					0		Breast(137;0.00043)	STAD - Stomach adenocarcinoma(17;0.000371)			GCAGGAGCTGATCTGGCAGCA	0.632													7	49	---	---	---	---	PASS
CRHR1	1394	broad.mit.edu	37	17	43908281	43908281	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr17:43908281G>T	uc010dap.2	+	9	1097	c.832G>T	c.(832-834)GGG>TGG	p.G278W	CRHR1_uc010wjx.1_Missense_Mutation_p.G74W|CRHR1_uc002ijp.2_Missense_Mutation_p.G148W|CRHR1_uc002ijm.2_Missense_Mutation_p.G249W|CRHR1_uc002ijn.2_Missense_Mutation_p.G209W|CRHR1_uc010dar.2_Missense_Mutation_p.G249W|CRHR1_uc010dao.2_Missense_Mutation_p.G148W|CRHR1_uc010daq.2_Missense_Mutation_p.G74W	NM_001145146	NP_001138618	P34998	CRFR1_HUMAN	corticotropin releasing hormone receptor 1	278	Helical; Name=4; (Potential).				female pregnancy|immune response|parturition	integral to plasma membrane	corticotrophin-releasing factor receptor activity|protein binding			lung(3)	3	Colorectal(2;0.0416)			BRCA - Breast invasive adenocarcinoma(366;0.161)		CTGGGCCATTGGGAAGCTGTA	0.463													33	42	---	---	---	---	PASS
NME1	4830	broad.mit.edu	37	17	49239125	49239125	+	Silent	SNP	A	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr17:49239125A>G	uc002iti.1	+	5	486	c.378A>G	c.(376-378)GCA>GCG	p.A126A	NME1_uc002ith.1_Silent_p.A151A|NME1-NME2_uc002itj.2_Intron|NME1-NME2_uc002itk.2_Intron	NM_000269	NP_000260	P15531	NDKA_HUMAN	non-metastatic cells 1, protein (NM23A)	126					cell differentiation|CTP biosynthetic process|endocytosis|GTP biosynthetic process|negative regulation of cell proliferation|nervous system development|nucleobase, nucleoside and nucleotide interconversion|positive regulation of DNA binding|positive regulation of epithelial cell proliferation|regulation of apoptosis|UTP biosynthetic process	cytosol|nucleus	ATP binding|deoxyribonuclease activity|GTP binding|identical protein binding|magnesium ion binding|nucleoside diphosphate kinase activity				0			BRCA - Breast invasive adenocarcinoma(22;1.54e-08)		Gemcitabine(DB00441)|Progesterone(DB00396)	TGGAGAGTGCAGAGAAGGAGA	0.483													57	39	---	---	---	---	PASS
KIF2B	84643	broad.mit.edu	37	17	51901317	51901317	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr17:51901317G>T	uc002iua.2	+	1	1079	c.923G>T	c.(922-924)GGG>GTG	p.G308V	uc010wna.1_RNA	NM_032559	NP_115948	Q8N4N8	KIF2B_HUMAN	kinesin family member 2B	308	ATP (By similarity).|Kinesin-motor.				blood coagulation|cell division|microtubule depolymerization|microtubule-based movement|mitotic prometaphase|regulation of chromosome segregation	condensed chromosome kinetochore|cytosol|microtubule|microtubule organizing center|nucleolus|spindle	ATP binding|microtubule motor activity			ovary(5)|skin(3)	8						ACGGGAAGTGGGAAGACGTAC	0.552													39	37	---	---	---	---	PASS
CEP192	55125	broad.mit.edu	37	18	13092463	13092463	+	Missense_Mutation	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr18:13092463G>A	uc010xac.1	+	34	6271	c.6191G>A	c.(6190-6192)AGA>AAA	p.R2064K	CEP192_uc010dlf.1_RNA|CEP192_uc010xad.1_Missense_Mutation_p.R1589K|CEP192_uc002kru.2_RNA|CEP192_uc002krv.2_Missense_Mutation_p.R486K|CEP192_uc002krw.2_Missense_Mutation_p.R213K|CEP192_uc002krx.2_Missense_Mutation_p.R68K|CEP192_uc002kry.2_RNA	NM_032142	NP_115518	E9PF99	E9PF99_HUMAN	centrosomal protein 192kDa	2064										ovary(4)|pancreas(1)	5						GGAGAATTCAGAGATTGCATT	0.343													22	49	---	---	---	---	PASS
MC5R	4161	broad.mit.edu	37	18	13826480	13826480	+	Missense_Mutation	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr18:13826480C>T	uc010xaf.1	+	1	716	c.716C>T	c.(715-717)ACC>ATC	p.T239I		NM_005913	NP_005904	P33032	MC5R_HUMAN	melanocortin 5 receptor	239	Cytoplasmic (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			ovary(3)|lung(2)|breast(1)	6						GGCGCGGTCACCGTCACCATG	0.617													17	160	---	---	---	---	PASS
DSG4	147409	broad.mit.edu	37	18	28993359	28993359	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr18:28993359C>A	uc002kwq.2	+	16	3059	c.2924C>A	c.(2923-2925)CCT>CAT	p.P975H	DSG4_uc002kwr.2_Missense_Mutation_p.P994H	NM_177986	NP_817123	Q86SJ6	DSG4_HUMAN	desmoglein 4 isoform 2 preproprotein	975	Cytoplasmic (Potential).				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			central_nervous_system(5)|ovary(3)	8			OV - Ovarian serous cystadenocarcinoma(10;0.00504)			CCTGGTGTGCCTGACATGAGC	0.433													77	144	---	---	---	---	PASS
PIK3C3	5289	broad.mit.edu	37	18	39609304	39609304	+	Nonsense_Mutation	SNP	A	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr18:39609304A>T	uc002lap.2	+	15	1664	c.1606A>T	c.(1606-1608)AGA>TGA	p.R536*	PIK3C3_uc010xcl.1_Nonsense_Mutation_p.R473*|PIK3C3_uc002laq.2_Nonsense_Mutation_p.R21*	NM_002647	NP_002638	Q8NEB9	PK3C3_HUMAN	catalytic phosphatidylinositol 3-kinase 3	536					cell cycle|cytokinesis|fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	midbody|phosphatidylinositol 3-kinase complex	1-phosphatidylinositol-3-kinase activity|ATP binding|protein binding			lung(8)|ovary(1)|breast(1)	10						TAAGTCTGTCAGAGTTATGCG	0.388										TSP Lung(28;0.18)			32	60	---	---	---	---	PASS
TCEB3C	162699	broad.mit.edu	37	18	44549187	44549187	+	Missense_Mutation	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr18:44549187G>A	uc010dnr.2	-	1	1112	c.1112C>T	c.(1111-1113)ACG>ATG	p.T371M	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_001100817	NP_001094287	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide	371	Activation domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding				0						CTGATCGGGCGTCCACCCTTC	0.587													36	441	---	---	---	---	PASS
TCEB3C	162699	broad.mit.edu	37	18	44555055	44555055	+	Missense_Mutation	SNP	G	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr18:44555055G>C	uc010xdb.1	-	1	1395	c.1159C>G	c.(1159-1161)CGA>GGA	p.R387G	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_145653	NP_663628	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide	387	Activation domain (By similarity).				regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding				0						TCTGTCTCTCGAGCGAGTGCG	0.567													33	625	---	---	---	---	PASS
ALPK2	115701	broad.mit.edu	37	18	56184260	56184260	+	Missense_Mutation	SNP	G	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr18:56184260G>C	uc002lhj.3	-	9	6034	c.5820C>G	c.(5818-5820)CAC>CAG	p.H1940Q		NM_052947	NP_443179	Q86TB3	ALPK2_HUMAN	heart alpha-kinase	1940	Alpha-type protein kinase.						ATP binding|protein serine/threonine kinase activity	p.H1301H(1)		ovary(7)|skin(5)|lung(1)|central_nervous_system(1)	14						GCATGAGGCCGTGCATCACTG	0.557													46	109	---	---	---	---	PASS
CDH20	28316	broad.mit.edu	37	18	59157860	59157860	+	Missense_Mutation	SNP	T	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr18:59157860T>C	uc010dps.1	+	1	86	c.74T>C	c.(73-75)CTG>CCG	p.L25P	CDH20_uc002lif.2_Missense_Mutation_p.L19P	NM_031891	NP_114097	Q9HBT6	CAD20_HUMAN	cadherin 20, type 2 preproprotein	25					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			breast(3)|ovary(1)|pancreas(1)	5		Colorectal(73;0.186)				TTCTGGGGGCTGATGGACCTT	0.502													40	96	---	---	---	---	PASS
ZNF236	7776	broad.mit.edu	37	18	74587471	74587471	+	Missense_Mutation	SNP	G	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr18:74587471G>C	uc002lmi.2	+	6	883	c.685G>C	c.(685-687)GAA>CAA	p.E229Q	ZNF236_uc002lmj.2_RNA|ZNF236_uc002lmk.1_Missense_Mutation_p.E229Q	NM_007345	NP_031371	Q9UL36	ZN236_HUMAN	zinc finger protein 236	229	C2H2-type 7.				cellular response to glucose stimulus	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)	4		Prostate(75;0.0405)|Esophageal squamous(42;0.129)|Melanoma(33;0.132)		OV - Ovarian serous cystadenocarcinoma(15;4.36e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0686)		CAAATGTAGTGAATGTGGAAA	0.448											OREG0025069	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	30	84	---	---	---	---	PASS
MIDN	90007	broad.mit.edu	37	19	1255030	1255030	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr19:1255030G>T	uc002lrp.2	+	6	1341	c.826G>T	c.(826-828)GCC>TCC	p.A276S		NM_177401	NP_796375	Q504T8	MIDN_HUMAN	midnolin	276						nucleolus					0		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;7.93e-06)|all_lung(49;1.25e-05)|Breast(49;0.000172)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		TGTGAATCACGCCCCGGGGGT	0.632													31	58	---	---	---	---	PASS
ADAMTSL5	339366	broad.mit.edu	37	19	1506294	1506294	+	Missense_Mutation	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr19:1506294C>T	uc002ltd.2	-	12	1580	c.1136G>A	c.(1135-1137)GGC>GAC	p.G379D	ADAMTSL5_uc010dsl.2_Missense_Mutation_p.G148D|ADAMTSL5_uc010xgq.1_Missense_Mutation_p.G389D	NM_213604	NP_998769	Q6ZMM2	ATL5_HUMAN	ADAMTS-like 5 precursor	379	NTR.					proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding				0		Acute lymphoblastic leukemia(61;5.61e-13)|all_hematologic(61;2.65e-08)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGGTGGTGGCCCAGCACTCG	0.647													13	30	---	---	---	---	PASS
ZNRF4	148066	broad.mit.edu	37	19	5455728	5455728	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr19:5455728C>A	uc002mca.3	+	1	303	c.226C>A	c.(226-228)CCG>ACG	p.P76T		NM_181710	NP_859061	Q8WWF5	ZNRF4_HUMAN	zinc and ring finger 4 precursor	76	Extracellular (Potential).					integral to membrane	zinc ion binding			large_intestine(2)	2				UCEC - Uterine corpus endometrioid carcinoma (162;0.0002)		GTGGCCACGGCCGGGCCGAGC	0.672													18	65	---	---	---	---	PASS
VAV1	7409	broad.mit.edu	37	19	6825111	6825111	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr19:6825111G>T	uc002mfu.1	+	7	799	c.702G>T	c.(700-702)GAG>GAT	p.E234D	VAV1_uc010xjh.1_Missense_Mutation_p.E202D|VAV1_uc010dva.1_Missense_Mutation_p.E234D|VAV1_uc002mfv.1_Missense_Mutation_p.E179D	NM_005428	NP_005419	P15498	VAV_HUMAN	vav 1 guanine nucleotide exchange factor	234	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|regulation of Rho protein signal transduction|small GTPase mediated signal transduction|T cell costimulation	cytosol|plasma membrane	metal ion binding|protein binding|sequence-specific DNA binding transcription factor activity			lung(4)|ovary(4)|breast(3)|central_nervous_system(2)|kidney(2)|skin(1)	16						AAGACATTGAGATCATCTTTA	0.542													35	113	---	---	---	---	PASS
FBN3	84467	broad.mit.edu	37	19	8130938	8130938	+	Silent	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr19:8130938C>A	uc002mjf.2	-	63	8316	c.8295G>T	c.(8293-8295)CGG>CGT	p.R2765R	FBN3_uc002mje.2_Silent_p.R561R	NM_032447	NP_115823	Q75N90	FBN3_HUMAN	fibrillin 3 precursor	2765						proteinaceous extracellular matrix	calcium ion binding|extracellular matrix structural constituent			ovary(6)|skin(3)|pancreas(1)|central_nervous_system(1)	11						CCGGCCGCCTCCGCCCCAGCT	0.682													38	104	---	---	---	---	PASS
MUC16	94025	broad.mit.edu	37	19	9046849	9046849	+	Missense_Mutation	SNP	G	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr19:9046849G>C	uc002mkp.2	-	5	34986	c.34782C>G	c.(34780-34782)AAC>AAG	p.N11594K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	11596	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TATGGGAAAAGTTGGGAATTG	0.517													31	61	---	---	---	---	PASS
MUC16	94025	broad.mit.edu	37	19	9070865	9070865	+	Silent	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr19:9070865G>A	uc002mkp.2	-	3	16785	c.16581C>T	c.(16579-16581)AGC>AGT	p.S5527S		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	5529	Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGGATGTTCTGCTAGAGGAGA	0.493													48	74	---	---	---	---	PASS
MUC16	94025	broad.mit.edu	37	19	9085224	9085224	+	Missense_Mutation	SNP	G	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr19:9085224G>C	uc002mkp.2	-	1	6795	c.6591C>G	c.(6589-6591)AAC>AAG	p.N2197K		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2197	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						ATGGATCCTTGTTCATTCTAA	0.483													31	50	---	---	---	---	PASS
ZNF709	163051	broad.mit.edu	37	19	12577614	12577614	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr19:12577614C>A	uc002mtv.3	-	2	215	c.54G>T	c.(52-54)TGG>TGT	p.W18C	ZNF709_uc002mtw.3_5'UTR|ZNF709_uc002mtx.3_Missense_Mutation_p.W18C	NM_152601	NP_689814	Q8N972	ZN709_HUMAN	zinc finger protein 709 isoform a	18	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCAGCAAAGCCCACTCCTCCT	0.478													52	109	---	---	---	---	PASS
PKN1	5585	broad.mit.edu	37	19	14578739	14578739	+	Missense_Mutation	SNP	C	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr19:14578739C>G	uc002myp.2	+	15	2104	c.1936C>G	c.(1936-1938)CTG>GTG	p.L646V	PKN1_uc002myq.2_Missense_Mutation_p.L652V|PKN1_uc002myr.2_5'UTR	NM_002741	NP_002732	Q16512	PKN1_HUMAN	protein kinase N1 isoform 2	646	Protein kinase.				activation of JUN kinase activity|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription, DNA-dependent	endosome|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|GTP-Rho binding|histone binding|histone deacetylase binding|histone kinase activity (H3-T11 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|Rac GTPase binding			ovary(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)	8						CATCAAGGCTCTGAAGAAAGG	0.607													20	42	---	---	---	---	PASS
NDUFB7	4713	broad.mit.edu	37	19	14682710	14682710	+	Nonsense_Mutation	SNP	T	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr19:14682710T>A	uc002mzg.2	-	1	177	c.103A>T	c.(103-105)AAG>TAG	p.K35*		NM_004146	NP_004137	P17568	NDUB7_HUMAN	NADH dehydrogenase (ubiquinone) 1 beta	35					mitochondrial electron transport, NADH to ubiquinone|transport	mitochondrial intermembrane space|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			ovary(1)	1					NADH(DB00157)	CCGCGCTCCTTGCGTTCGGGG	0.736													7	20	---	---	---	---	PASS
JAK3	3718	broad.mit.edu	37	19	17945801	17945801	+	Missense_Mutation	SNP	T	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr19:17945801T>C	uc002nhn.3	-	16	2159	c.2059A>G	c.(2059-2061)AGG>GGG	p.R687G	JAK3_uc010ebh.2_Intron|JAK3_uc002nho.2_Missense_Mutation_p.R687G	NM_000215	NP_000206	P52333	JAK3_HUMAN	Janus kinase 3	687	Protein kinase 1.				B cell differentiation|cytokine-mediated signaling pathway|enzyme linked receptor protein signaling pathway|intracellular protein kinase cascade|negative regulation of dendritic cell cytokine production|negative regulation of FasL biosynthetic process|negative regulation of interleukin-10 production|negative regulation of interleukin-12 production|negative regulation of T-helper 1 cell differentiation|negative regulation of thymocyte apoptosis|peptidyl-tyrosine phosphorylation|positive regulation of anti-apoptosis|response to interleukin-15|response to interleukin-2|response to interleukin-4|response to interleukin-9|T cell homeostasis	cytoskeleton|cytosol|endomembrane system|membrane	ATP binding|non-membrane spanning protein tyrosine kinase activity|protein binding			haematopoietic_and_lymphoid_tissue(40)|lung(5)|breast(5)|ovary(3)|stomach(2)|upper_aerodigestive_tract(1)	56						CAGGGGATCCTGTCGGTGAGC	0.612		2	Mis		acute megakaryocytic leukemia|								45	80	---	---	---	---	PASS
ZNF93	81931	broad.mit.edu	37	19	20044384	20044384	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr19:20044384G>T	uc002non.2	+	4	731	c.620G>T	c.(619-621)GGC>GTC	p.G207V		NM_031218	NP_112495	P35789	ZNF93_HUMAN	zinc finger protein 93	207	C2H2-type 3.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			pancreas(1)	1						GAAGAATGTGGCAAAGCCTTT	0.363													7	37	---	---	---	---	PASS
ZNF566	84924	broad.mit.edu	37	19	36940165	36940165	+	Missense_Mutation	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr19:36940165G>A	uc002oea.3	-	5	1053	c.971C>T	c.(970-972)TCA>TTA	p.S324L	ZNF566_uc010xte.1_Missense_Mutation_p.S324L|ZNF566_uc010xtf.1_Missense_Mutation_p.S325L|ZNF566_uc002oeb.3_Missense_Mutation_p.S324L|ZNF566_uc002oec.3_Missense_Mutation_p.S220L|ZNF566_uc010xtg.1_Missense_Mutation_p.S220L	NM_032838	NP_116227	Q969W8	ZN566_HUMAN	zinc finger protein 566 isoform 1	324	C2H2-type 5.|C2H2-type 6.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Esophageal squamous(110;0.162)					AATAAGTTGTGAGCTCTGACT	0.393													22	65	---	---	---	---	PASS
LGALS13	29124	broad.mit.edu	37	19	40097920	40097920	+	Missense_Mutation	SNP	G	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr19:40097920G>C	uc002omb.2	+	4	401	c.361G>C	c.(361-363)GTG>CTG	p.V121L		NM_013268	NP_037400	Q9UHV8	PP13_HUMAN	galectin-13	121	Galectin.				lipid catabolic process|phospholipid metabolic process		carboxylesterase activity|lysophospholipase activity|sugar binding			ovary(1)	1	all_cancers(60;1.77e-05)|all_lung(34;5.38e-08)|Lung NSC(34;6.37e-08)|Ovarian(47;0.116)		Epithelial(26;3.28e-26)|OV - Ovarian serous cystadenocarcinoma(5;7.31e-25)|all cancers(26;1.15e-23)|LUSC - Lung squamous cell carcinoma(53;0.00281)			GCCATCATTTGTGAAGATGGT	0.448													35	69	---	---	---	---	PASS
FCGBP	8857	broad.mit.edu	37	19	40362888	40362888	+	Missense_Mutation	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr19:40362888G>A	uc002omp.3	-	32	15190	c.15182C>T	c.(15181-15183)GCG>GTG	p.A5061V		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	5061	VWFD 12.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CTGGCAGGTCGCGAAGGGGCC	0.652													7	183	---	---	---	---	PASS
SHKBP1	92799	broad.mit.edu	37	19	41086788	41086788	+	Missense_Mutation	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr19:41086788G>A	uc002oob.2	+	9	839	c.790G>A	c.(790-792)GGC>AGC	p.G264S	SHKBP1_uc002ooc.2_Missense_Mutation_p.G264S|SHKBP1_uc002ood.2_Missense_Mutation_p.G264S|SHKBP1_uc010xvl.1_Missense_Mutation_p.G187S|SHKBP1_uc002ooe.2_Missense_Mutation_p.G101S|SHKBP1_uc002oof.2_Missense_Mutation_p.G101S|SHKBP1_uc010xvm.1_Missense_Mutation_p.G101S|SHKBP1_uc010xvn.1_Missense_Mutation_p.G142S	NM_138392	NP_612401	Q8TBC3	SHKB1_HUMAN	SH3KBP1 binding protein 1	264	WD 1.					voltage-gated potassium channel complex	voltage-gated potassium channel activity			ovary(1)|pancreas(1)	2			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			AGCAGCCACCGGCAGCGAGAT	0.607													20	113	---	---	---	---	PASS
CYP2A13	1553	broad.mit.edu	37	19	41594547	41594547	+	Silent	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr19:41594547C>A	uc002opt.2	+	1	180	c.171C>A	c.(169-171)TCC>TCA	p.S57S		NM_000766	NP_000757	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A,	57					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			ovary(2)|skin(1)	3					Clomipramine(DB01242)|Nicotine(DB00184)	TGTACAACTCCCTCATGAAGG	0.612													26	82	---	---	---	---	PASS
ZNF229	7772	broad.mit.edu	37	19	44932887	44932887	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr19:44932887C>A	uc002oze.1	-	6	2503	c.2069G>T	c.(2068-2070)GGC>GTC	p.G690V	ZNF229_uc010ejk.1_Missense_Mutation_p.G344V|ZNF229_uc010ejl.1_Missense_Mutation_p.G684V	NM_014518	NP_055333	Q9UJW7	ZN229_HUMAN	zinc finger protein 229	690	C2H2-type 14.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(2)|ovary(1)|pancreas(1)	4		Prostate(69;0.0352)				GAATCCCTTGCCACACTGATC	0.488													53	120	---	---	---	---	PASS
GEMIN7	79760	broad.mit.edu	37	19	45593579	45593579	+	Silent	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr19:45593579C>T	uc002pap.1	+	3	358	c.207C>T	c.(205-207)AGC>AGT	p.S69S	uc002pas.2_5'Flank|GEMIN7_uc002paq.1_Silent_p.S69S|GEMIN7_uc002par.1_Silent_p.S69S	NM_001007270	NP_001007271	Q9H840	GEMI7_HUMAN	gemin 7	69					ncRNA metabolic process|spliceosomal snRNP assembly	Cajal body|cytosol|spliceosomal complex	protein binding			ovary(1)	1		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0131)		ACCTCCGCAGCCTGCTGGCCA	0.617													11	29	---	---	---	---	PASS
ZNF114	163071	broad.mit.edu	37	19	48789058	48789058	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr19:48789058G>T	uc002pil.1	+	6	674	c.177G>T	c.(175-177)CAG>CAT	p.Q59H	ZNF114_uc010elv.1_Missense_Mutation_p.Q59H|ZNF114_uc002pim.1_Missense_Mutation_p.Q59H|ZNF114_uc002pin.2_Missense_Mutation_p.Q25H	NM_153608	NP_705836	Q8NC26	ZN114_HUMAN	zinc finger protein 114	59	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_epithelial(76;8.01e-05)|all_lung(116;0.000112)|Lung NSC(112;0.000192)|Prostate(7;0.0187)|all_neural(266;0.0228)|Ovarian(192;0.113)		OV - Ovarian serous cystadenocarcinoma(262;7.56e-05)|all cancers(93;0.000113)|Epithelial(262;0.00962)|GBM - Glioblastoma multiforme(486;0.0153)		CAACCCCTCAGCCGGATATTC	0.438													44	92	---	---	---	---	PASS
SIGLEC14	100049587	broad.mit.edu	37	19	52147192	52147192	+	Silent	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr19:52147192C>A	uc002pxf.3	-	5	972	c.852G>T	c.(850-852)CTG>CTT	p.L284L		NM_001098612	NP_001092082	Q08ET2	SIG14_HUMAN	sialic acid binding Ig-like lectin 14 precursor	284	Extracellular (Potential).|Ig-like C2-type 2.				cell adhesion	integral to membrane|plasma membrane	protein binding|sugar binding			ovary(1)	1		all_neural(266;0.0299)		GBM - Glioblastoma multiforme(134;0.000965)|OV - Ovarian serous cystadenocarcinoma(262;0.0195)		GGAACCAGCTCAGTGAGGCAG	0.602													23	54	---	---	---	---	PASS
LILRA1	11024	broad.mit.edu	37	19	55106308	55106308	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr19:55106308C>A	uc002qgh.1	+	4	431	c.249C>A	c.(247-249)TTC>TTA	p.F83L	LILRA2_uc010yfg.1_Intron|LILRA1_uc010yfh.1_Missense_Mutation_p.F83L	NM_006863	NP_006854	O75019	LIRA1_HUMAN	leukocyte immunoglobulin-like receptor,	83	Ig-like C2-type 1.|Extracellular (Potential).				cell surface receptor linked signaling pathway|defense response|regulation of immune response	integral to membrane|plasma membrane	antigen binding|transmembrane receptor activity			skin(2)|ovary(1)	3				GBM - Glioblastoma multiforme(193;0.0348)		AGGGCCAGTTCCCCATCCCAT	0.567													60	115	---	---	---	---	PASS
NLRP13	126204	broad.mit.edu	37	19	56422082	56422082	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr19:56422082G>T	uc010ygg.1	-	6	2154	c.2129C>A	c.(2128-2130)TCC>TAC	p.S710Y		NM_176810	NP_789780	Q86W25	NAL13_HUMAN	NACHT, leucine rich repeat and PYD containing	710							ATP binding			skin(4)|ovary(3)|pancreas(1)|lung(1)	9		Colorectal(82;3.48e-05)|Ovarian(87;0.0481)|Renal(1328;0.218)		GBM - Glioblastoma multiforme(193;0.0642)		GTGCATCCTGGAATCAAACTT	0.458													62	118	---	---	---	---	PASS
ZNF8	7554	broad.mit.edu	37	19	58806806	58806806	+	Silent	SNP	A	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr19:58806806A>G	uc002qry.1	+	4	1762	c.1632A>G	c.(1630-1632)CAA>CAG	p.Q544Q	ZNF8_uc002qrz.2_RNA	NM_021089	NP_066575	P17098	ZNF8_HUMAN	zinc finger protein 8	544					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;6.46e-05)|Lung NSC(17;0.0233)|all_neural(62;0.0381)|all_epithelial(17;0.0427)|all_lung(17;0.057)|Ovarian(87;0.17)|Colorectal(82;0.227)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.00619)		TTGACATCCAAAAAATCATGC	0.502													10	79	---	---	---	---	PASS
PDYN	5173	broad.mit.edu	37	20	1961487	1961487	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr20:1961487C>A	uc010gaj.2	-	3	489	c.247G>T	c.(247-249)GGG>TGG	p.G83W	uc002wfu.1_Intron|PDYN_uc002wfv.2_Missense_Mutation_p.G83W|PDYN_uc010zpt.1_Intron	NM_024411	NP_077722	P01213	PDYN_HUMAN	beta-neoendorphin-dynorphin preproprotein	83					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			upper_aerodigestive_tract(1)|ovary(1)	2						GACTTGCTCCCCAAGTCCTCC	0.562													63	61	---	---	---	---	PASS
PDYN	5173	broad.mit.edu	37	20	1961488	1961488	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr20:1961488C>A	uc010gaj.2	-	3	488	c.246G>T	c.(244-246)TTG>TTT	p.L82F	uc002wfu.1_Intron|PDYN_uc002wfv.2_Missense_Mutation_p.L82F|PDYN_uc010zpt.1_Intron	NM_024411	NP_077722	P01213	PDYN_HUMAN	beta-neoendorphin-dynorphin preproprotein	82					cell death|neuropeptide signaling pathway|synaptic transmission	extracellular region|plasma membrane	opioid peptide activity			upper_aerodigestive_tract(1)|ovary(1)	2						ACTTGCTCCCCAAGTCCTCCT	0.562													65	58	---	---	---	---	PASS
TGM6	343641	broad.mit.edu	37	20	2375122	2375122	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr20:2375122G>T	uc002wfy.1	+	2	93	c.32G>T	c.(31-33)TGG>TTG	p.W11L	TGM6_uc010gal.1_Missense_Mutation_p.W11L	NM_198994	NP_945345	O95932	TGM3L_HUMAN	transglutaminase 6	11					cell death|peptide cross-linking		acyltransferase activity|metal ion binding|protein-glutamine gamma-glutamyltransferase activity			ovary(3)|skin(1)	4					L-Glutamine(DB00130)	AAGGTGGACTGGCAGCGGTCG	0.637													13	72	---	---	---	---	PASS
SIGLEC1	6614	broad.mit.edu	37	20	3673306	3673306	+	Missense_Mutation	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr20:3673306C>T	uc002wja.2	-	15	3892	c.3892G>A	c.(3892-3894)GGT>AGT	p.G1298S	SIGLEC1_uc002wjb.1_5'UTR|SIGLEC1_uc002wiz.3_Missense_Mutation_p.G1298S	NM_023068	NP_075556	Q9BZZ2	SN_HUMAN	sialoadhesin precursor	1298	Ig-like C2-type 13.|Extracellular (Potential).				cell-cell adhesion|cell-matrix adhesion|endocytosis|inflammatory response	extracellular region|integral to membrane|plasma membrane	sugar binding			pancreas(4)|ovary(2)|skin(2)|breast(1)|central_nervous_system(1)	10						AGCCAACGACCGTTGTGGTAC	0.657													12	83	---	---	---	---	PASS
CST4	1472	broad.mit.edu	37	20	23669511	23669511	+	Silent	SNP	A	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr20:23669511A>T	uc002wto.1	-	1	152	c.96T>A	c.(94-96)GGT>GGA	p.G32G		NM_001899	NP_001890	P01036	CYTS_HUMAN	cystatin S precursor	32		Reactive site.				extracellular region	cysteine-type endopeptidase inhibitor activity			breast(1)	1	Lung NSC(19;0.0789)|Colorectal(13;0.0993)|all_lung(19;0.169)					CATAGATGCCACCTGGGATTA	0.562													24	98	---	---	---	---	PASS
NINL	22981	broad.mit.edu	37	20	25493536	25493536	+	Silent	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr20:25493536C>T	uc002wux.1	-	4	458	c.384G>A	c.(382-384)CCG>CCA	p.P128P	NINL_uc010gdn.1_Silent_p.P128P|NINL_uc010gdo.1_5'UTR|NINL_uc010ztf.1_Silent_p.P144P	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	128					G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						TTTGCTGCTCCGGCACGCGTC	0.627													7	106	---	---	---	---	PASS
CDK5RAP1	51654	broad.mit.edu	37	20	31960462	31960462	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr20:31960462C>A	uc010gek.2	-	11	1413	c.1289G>T	c.(1288-1290)AGA>ATA	p.R430I	CDK5RAP1_uc002wyy.2_Missense_Mutation_p.R326I|CDK5RAP1_uc002wyz.2_Missense_Mutation_p.R416I|CDK5RAP1_uc002wza.2_Missense_Mutation_p.R416I|CDK5RAP1_uc010gel.2_Missense_Mutation_p.R325I|CDK5RAP1_uc010gem.2_Missense_Mutation_p.R339I|CDK5RAP1_uc002wzc.1_Missense_Mutation_p.R416I|CDK5RAP1_uc002wzb.1_Missense_Mutation_p.R51I	NM_016408	NP_057492	Q96SZ6	CK5P1_HUMAN	CDK5 regulatory subunit associated protein 1	430					brain development|negative regulation of cyclin-dependent protein kinase activity|regulation of neuron differentiation|tRNA modification	cytoplasm	4 iron, 4 sulfur cluster binding|metal ion binding|neuronal Cdc2-like kinase binding|transferase activity			ovary(2)|skin(2)|lung(1)	5						AATAGATTCTCTAATATGGTG	0.368													29	75	---	---	---	---	PASS
BPI	671	broad.mit.edu	37	20	36954788	36954788	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr20:36954788C>A	uc002xib.2	+	10	1189	c.1127C>A	c.(1126-1128)GCC>GAC	p.A376D		NM_001725	NP_001716	P17213	BPI_HUMAN	bactericidal/permeability-increasing protein	376					defense response to bacterium|negative regulation of interleukin-6 production|negative regulation of interleukin-8 production|negative regulation of macrophage activation|negative regulation of tumor necrosis factor production	extracellular region|integral to plasma membrane	lipid binding|lipopolysaccharide binding			ovary(4)	4		Myeloproliferative disorder(115;0.00878)				CAGGCCTTTGCCGTCCTCCCC	0.493													8	30	---	---	---	---	PASS
FAM65C	140876	broad.mit.edu	37	20	49218725	49218725	+	Missense_Mutation	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr20:49218725C>T	uc002xvm.2	-	13	1849	c.1531G>A	c.(1531-1533)GTG>ATG	p.V511M	FAM65C_uc010zyt.1_Missense_Mutation_p.V515M|FAM65C_uc010zyu.1_RNA|FAM65C_uc002xvn.1_Missense_Mutation_p.V511M	NM_080829	NP_543019	Q96MK2	FA65C_HUMAN	hypothetical protein LOC140876	511										ovary(2)	2						TCGAGGGCCACGCCAGGCCCG	0.692													5	22	---	---	---	---	PASS
SS18L1	26039	broad.mit.edu	37	20	60738679	60738679	+	Splice_Site	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr20:60738679G>T	uc002ycb.2	+	6	776	c.721_splice	c.e6+1	p.G241_splice	SS18L1_uc011aaa.1_Splice_Site_p.G241_splice|SS18L1_uc002ybz.1_Splice_Site|SS18L1_uc002yca.1_Splice_Site|SS18L1_uc002ycc.1_Splice_Site	NM_198935	NP_945173	O75177	CREST_HUMAN	SS18-like protein 1						chromatin modification|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed chromosome kinetochore				ovary(2)	2	Breast(26;3.97e-09)		BRCA - Breast invasive adenocarcinoma(19;1.92e-08)			TCCCAGCAAGGTAACGCCCGG	0.706			T	SSX1	synovial sarcoma								12	15	---	---	---	---	PASS
TMPRSS15	5651	broad.mit.edu	37	21	19670050	19670050	+	Splice_Site	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr21:19670050C>A	uc002ykw.2	-	19	2292	c.2261_splice	c.e19+1	p.S754_splice		NM_002772	NP_002763	P98073	ENTK_HUMAN	enterokinase precursor						proteolysis	brush border|integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			ovary(5)|upper_aerodigestive_tract(1)|breast(1)|skin(1)	8						TAGGGACCCACCTGGGTGTTA	0.418													8	55	---	---	---	---	PASS
AGPAT3	56894	broad.mit.edu	37	21	45391324	45391324	+	Silent	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr21:45391324G>A	uc002zdv.2	+	7	942	c.720G>A	c.(718-720)CTG>CTA	p.L240L	AGPAT3_uc002zdw.2_Silent_p.L240L|AGPAT3_uc002zdx.2_Silent_p.L327L|AGPAT3_uc002zdy.2_Silent_p.L178L	NM_020132	NP_064517	Q9NRZ7	PLCC_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 3	240	Lumenal (Potential).				phospholipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	1-acylglycerol-3-phosphate O-acyltransferase activity				0				STAD - Stomach adenocarcinoma(101;0.18)|Colorectal(79;0.24)		ACCCGTCCCTGCTGGGGATCC	0.607													26	134	---	---	---	---	PASS
TRPM2	7226	broad.mit.edu	37	21	45811378	45811378	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr21:45811378G>T	uc002zet.1	+	12	1877	c.1664G>T	c.(1663-1665)CGC>CTC	p.R555L	TRPM2_uc002zeu.1_Missense_Mutation_p.R555L|TRPM2_uc002zew.1_Missense_Mutation_p.R555L|TRPM2_uc010gpt.1_Missense_Mutation_p.R555L|TRPM2_uc002zex.1_Missense_Mutation_p.R341L|TRPM2_uc002zey.1_Missense_Mutation_p.R68L	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	555	Cytoplasmic (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						gcggcgccccgccTGCAGATG	0.602													4	12	---	---	---	---	PASS
C21orf29	54084	broad.mit.edu	37	21	45947267	45947267	+	Missense_Mutation	SNP	C	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr21:45947267C>T	uc002zfe.1	-	7	1123	c.1057G>A	c.(1057-1059)GTC>ATC	p.V353I	C21orf29_uc010gpv.1_Missense_Mutation_p.V285I	NM_144991	NP_659428	Q8WU66	TSEAR_HUMAN	chromosome 21 open reading frame 29 precursor	353	EAR 1.				cell adhesion	extracellular region	structural molecule activity				0						CACTTGTAGACGGCGGATGTG	0.552													14	134	---	---	---	---	PASS
CECR2	27443	broad.mit.edu	37	22	17990897	17990897	+	Missense_Mutation	SNP	A	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr22:17990897A>G	uc010gqw.1	+	7	923	c.797A>G	c.(796-798)GAC>GGC	p.D266G	CECR2_uc010gqv.1_Missense_Mutation_p.D145G|CECR2_uc002zml.2_Missense_Mutation_p.D145G|CECR2_uc002zmm.1_Intron	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	308					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)		TGGATGTCTGACCACCTGTCC	0.473													42	130	---	---	---	---	PASS
CECR2	27443	broad.mit.edu	37	22	18020403	18020403	+	Missense_Mutation	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr22:18020403G>A	uc010gqw.1	+	13	1858	c.1732G>A	c.(1732-1734)GAG>AAG	p.E578K	CECR2_uc010gqv.1_Missense_Mutation_p.E437K|CECR2_uc002zml.2_Missense_Mutation_p.E437K	NM_031413	NP_113601	Q9BXF3	CECR2_HUMAN	cat eye syndrome chromosome region, candidate 2	620					chromatin modification|cytokinesis|cytoskeleton organization|DNA fragmentation involved in apoptotic nuclear change|vesicle-mediated transport		protein binding			ovary(1)|skin(1)	2		all_epithelial(15;0.139)		Lung(27;0.146)		GCCCCCGCGGGAGGTGGGCAC	0.592													37	51	---	---	---	---	PASS
DUSP18	150290	broad.mit.edu	37	22	31059940	31059940	+	Silent	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr22:31059940G>A	uc003aiu.2	-	2	552	c.51C>T	c.(49-51)GTC>GTT	p.V17V	SLC35E4_uc003ait.2_Intron|DUSP18_uc010gwa.1_RNA|DUSP18_uc003aiw.1_Silent_p.V17V	NM_152511	NP_689724	Q8NEJ0	DUS18_HUMAN	dual specificity phosphatase 18	17						cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0						AGAGGCCGCTGACTGAGGGCT	0.567													26	43	---	---	---	---	PASS
OSBP2	23762	broad.mit.edu	37	22	31091240	31091240	+	Missense_Mutation	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr22:31091240G>A	uc003aiy.1	+	1	448	c.344G>A	c.(343-345)GGG>GAG	p.G115E	OSBP2_uc011ala.1_Intron|OSBP2_uc010gwc.1_Intron|OSBP2_uc003aix.1_Missense_Mutation_p.G115E|OSBP2_uc011alb.1_Missense_Mutation_p.G115E|OSBP2_uc003aiz.1_Missense_Mutation_p.G115E	NM_030758	NP_110385	Q969R2	OSBP2_HUMAN	oxysterol binding protein 2 isoform a	115					lipid transport	membrane	lipid binding			breast(1)|skin(1)	2						TCAGGTGTAGGGGCTGGGCCC	0.677													29	46	---	---	---	---	PASS
SCUBE1	80274	broad.mit.edu	37	22	43623418	43623418	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr22:43623418G>T	uc003bdt.1	-	10	1257	c.1169C>A	c.(1168-1170)CCG>CAG	p.P390Q		NM_173050	NP_766638	Q8IWY4	SCUB1_HUMAN	signal peptide, CUB domain, EGF-like 1	390	EGF-like 9; calcium-binding (Potential).				adult heart development|blood coagulation|endothelial cell differentiation|inflammatory response|post-embryonic development|protein homooligomerization	external side of plasma membrane|extracellular space|extrinsic to plasma membrane	calcium ion binding|identical protein binding|protein heterodimerization activity			central_nervous_system(2)|ovary(1)|lung(1)|skin(1)	5		all_neural(38;0.0414)|Ovarian(80;0.07)				CCGCCTCCCCGGGGGACAGAC	0.667													12	25	---	---	---	---	PASS
PNPLA3	80339	broad.mit.edu	37	22	44323026	44323026	+	Silent	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr22:44323026G>T	uc003bei.1	+	2	572	c.399G>T	c.(397-399)CGG>CGT	p.R133R	PNPLA3_uc010gzm.1_RNA	NM_025225	NP_079501	Q9NST1	PLPL3_HUMAN	patatin-like phospholipase domain containing 3	133	Lumenal (Potential).|Patatin.				triglyceride biosynthetic process|triglyceride catabolic process	integral to membrane	diolein transacylation activity|mono-olein transacylation activity|phospholipase A2 activity|triglyceride lipase activity				0		Ovarian(80;0.024)|all_neural(38;0.0416)				CTGACTTTCGGTCCAAAGACG	0.418													17	60	---	---	---	---	PASS
REPS2	9185	broad.mit.edu	37	X	17072970	17072970	+	Silent	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chrX:17072970G>T	uc004cxv.1	+	8	1182	c.1011G>T	c.(1009-1011)CTG>CTT	p.L337L	REPS2_uc004cxw.1_Silent_p.L336L|REPS2_uc011miw.1_Silent_p.L196L	NM_004726	NP_004717	Q8NFH8	REPS2_HUMAN	RALBP1 associated Eps domain containing 2	337	EH 2.|EF-hand.|Potential.				epidermal growth factor receptor signaling pathway|protein complex assembly	cytoplasm	calcium ion binding|protein binding			skin(2)|central_nervous_system(1)	3	Hepatocellular(33;0.183)					CCCTGACCCTGCCTGAGTTCT	0.527													24	34	---	---	---	---	PASS
NHS	4810	broad.mit.edu	37	X	17394302	17394302	+	Missense_Mutation	SNP	A	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chrX:17394302A>T	uc004cxx.2	+	1	760	c.422A>T	c.(421-423)GAC>GTC	p.D141V	NHS_uc011mix.1_Missense_Mutation_p.D141V	NM_198270	NP_938011	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome protein isoform 1	141						nucleus				skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	Hepatocellular(33;0.183)					CAGCTCTCGGACGTGGCCCGG	0.602													7	5	---	---	---	---	PASS
FAM47C	442444	broad.mit.edu	37	X	37028600	37028600	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chrX:37028600C>A	uc004ddl.1	+	1	2131	c.2117C>A	c.(2116-2118)CCT>CAT	p.P706H		NM_001013736	NP_001013758	Q5HY64	FA47C_HUMAN	hypothetical protein LOC442444	706										ovary(3)	3						CACCCAGAGCCTCCCAAGACT	0.632													20	26	---	---	---	---	PASS
RLIM	51132	broad.mit.edu	37	X	73811973	73811973	+	Missense_Mutation	SNP	C	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chrX:73811973C>A	uc004ebu.2	-	5	1467	c.1177G>T	c.(1177-1179)GGT>TGT	p.G393C	RLIM_uc004ebw.2_Missense_Mutation_p.G393C	NM_183353	NP_899196	Q9NVW2	RNF12_HUMAN	ring finger protein, LIM domain interacting	393					random inactivation of X chromosome|transcription, DNA-dependent|ubiquitin-dependent protein catabolic process	cytoplasm|transcriptional repressor complex	transcription corepressor activity|ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						TCACTTAAACCAGTATTTAAG	0.413													29	24	---	---	---	---	PASS
SMARCA1	6594	broad.mit.edu	37	X	128650319	128650319	+	Missense_Mutation	SNP	A	C	C			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chrX:128650319A>C	uc004eun.3	-	3	530	c.417T>G	c.(415-417)ATT>ATG	p.I139M	SMARCA1_uc004eup.3_Missense_Mutation_p.I139M|SMARCA1_uc011muk.1_Missense_Mutation_p.I139M|SMARCA1_uc011mul.1_Missense_Mutation_p.I139M	NM_003069	NP_003060	P28370	SMCA1_HUMAN	SWI/SNF-related matrix-associated	139					ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			ovary(3)|skin(1)	4						CTCCAGCAGAAATTAAGCTCT	0.264													42	25	---	---	---	---	PASS
BCORL1	63035	broad.mit.edu	37	X	129148945	129148945	+	Missense_Mutation	SNP	G	A	A			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chrX:129148945G>A	uc004evb.1	+	4	2311	c.2197G>A	c.(2197-2199)GAC>AAC	p.D733N	BCORL1_uc010nrd.1_Missense_Mutation_p.D635N	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	733					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						GCTGAACAAAGACCCCAACCT	0.597													12	19	---	---	---	---	PASS
GPC3	2719	broad.mit.edu	37	X	133087079	133087079	+	Missense_Mutation	SNP	T	G	G			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chrX:133087079T>G	uc004exe.1	-	2	525	c.335A>C	c.(334-336)CAA>CCA	p.Q112P	GPC3_uc010nrn.1_Missense_Mutation_p.Q112P|GPC3_uc011mvh.1_Intron|GPC3_uc010nro.1_Intron|GPC3_uc010nrp.1_5'UTR	NM_004484	NP_004475	P51654	GPC3_HUMAN	glypican 3 isoform 2 precursor	112						extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding|peptidyl-dipeptidase inhibitor activity			lung(2)|prostate(1)|breast(1)|skin(1)	5	Acute lymphoblastic leukemia(192;0.000127)					GAACTCACCTTGGAAAACCGC	0.383			T|D|Mis|N|F|S			Wilms tumour			Simpson-Golabi-Behmel_syndrome				75	53	---	---	---	---	PASS
MAGEC1	9947	broad.mit.edu	37	X	140995924	140995924	+	Missense_Mutation	SNP	G	T	T			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chrX:140995924G>T	uc004fbt.2	+	4	3020	c.2734G>T	c.(2734-2736)GTG>TTG	p.V912L	MAGEC1_uc010nsl.1_5'UTR	NM_005462	NP_005453	O60732	MAGC1_HUMAN	melanoma antigen family C, 1	912	MAGE.						protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4	Acute lymphoblastic leukemia(192;6.56e-05)					GGATGAAAAGGTGGACGAGTT	0.483										HNSCC(15;0.026)			69	78	---	---	---	---	PASS
COL11A2	1302	broad.mit.edu	37	6	33141171	33141171	+	Frame_Shift_Del	DEL	G	-	-			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr6:33141171delG	uc003ocx.1	-	37	2918	c.2690delC	c.(2689-2691)CCTfs	p.P897fs	COL11A2_uc010jul.1_Intron|COL11A2_uc003ocy.1_Frame_Shift_Del_p.P811fs|COL11A2_uc003ocz.1_Frame_Shift_Del_p.P790fs	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	897	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						ATCCTTCCCAGGGGGGCCCTG	0.597													41	28	---	---	---	---	
VPS13B	157680	broad.mit.edu	37	8	100833601	100833602	+	In_Frame_Ins	INS	-	GAC	GAC			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr8:100833601_100833602insGAC	uc003yiv.2	+	50	9260_9261	c.9149_9150insGAC	c.(9148-9150)CTG>CTGACG	p.3051_3052insT	VPS13B_uc003yiw.2_In_Frame_Ins_p.3026_3027insT	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	3051_3052					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			GTCCATAACCTGACATCTCCAA	0.396													74	62	---	---	---	---	
OR5M1	390168	broad.mit.edu	37	11	56380387	56380387	+	Frame_Shift_Del	DEL	C	-	-			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr11:56380387delC	uc001nja.1	-	1	592	c.592delG	c.(592-594)GCAfs	p.A198fs		NM_001004740	NP_001004740	Q8NGP8	OR5M1_HUMAN	olfactory receptor, family 5, subfamily M,	198	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1						ACAAACATTGCCATCTTTTTG	0.443													51	32	---	---	---	---	
VWA3A	146177	broad.mit.edu	37	16	22163889	22163889	+	Frame_Shift_Del	DEL	C	-	-			TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr16:22163889delC	uc010vbq.1	+	31	3435	c.3339delC	c.(3337-3339)TGCfs	p.C1113fs	VWA3A_uc010bxd.2_RNA|VWA3A_uc002dkg.3_Frame_Shift_Del_p.C191fs|VWA3A_uc010bxe.1_Frame_Shift_Del_p.C215fs	NM_173615	NP_775886	A6NCI4	VWA3A_HUMAN	von Willebrand factor A domain containing 3A	1113	VWFA 2.					extracellular region				skin(1)	1				GBM - Glioblastoma multiforme(48;0.0439)		GCTATCACTGCCCTGTGGGTG	0.557													23	10	---	---	---	---	
KANK3	256949	broad.mit.edu	37	19	8398950	8398961	+	In_Frame_Del	DEL	TCGCTGTCGCCA	-	-	rs111751275		TCGA-34-5239-01A-21D-1817-08	TCGA-34-5239-10A-01D-1817-08									Somatic	Phase_I	Capture				Illumina GAIIx	6e596912-2146-4c4f-97b6-70b610f5d4b4	57519424-2b08-4d99-b4a8-d57630c10ab4	g.chr19:8398950_8398961delTCGCTGTCGCCA	uc010dwa.2	-	5	1533_1544	c.1467_1478delTGGCGACAGCGA	c.(1465-1479)GATGGCGACAGCGAG>GAG	p.DGDS489del	KANK3_uc002mjp.1_In_Frame_Del_p.MATA1del	NM_198471	NP_940873	Q6NY19	KANK3_HUMAN	ankyrin repeat domain 47	489_492											0						GCCACCGTTCTCGCTGTCGCCATCGCTGTCGC	0.693													6	3	---	---	---	---	
