Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
ZNF461	92283	broad.mit.edu	37	19	37129608	37129608	+	Missense_Mutation	SNP	C	C	T			TCGA-ET-A3BV-01A-11D-A19J-08	TCGA-ET-A3BV-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a91d8c86-def8-41d7-b05e-d94b9c9303ac	21a53d88-27f7-4d6a-8667-cdb3580062eb	g.chr19:37129608C>T	uc002oem.3	-	5	1867	c.1639G>A	c.(1639-1641)Gag>Aag	p.E547K	ZNF461_uc002oen.3_Missense_Mutation_p.E516K|ZNF461_uc010xtj.2_Missense_Mutation_p.E524K	NM_153257	NP_694989	Q8TAF7	ZN461_HUMAN	Homo sapiens zinc finger protein 461 (ZNF461), mRNA.	547					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(4)|lung(17)|prostate(1)|urinary_tract(2)	29	Esophageal squamous(110;0.198)		COAD - Colon adenocarcinoma(19;0.0454)|Colorectal(19;0.065)			ACTGGCTTCTCGCCAGTATGA	0.383000													3	27					0	0	1	0	0
RAPGEFL1	51195	broad.mit.edu	37	17	38345558	38345558	+	Missense_Mutation	SNP	C	C	G			TCGA-ET-A3BV-01A-11D-A19J-08	TCGA-ET-A3BV-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a91d8c86-def8-41d7-b05e-d94b9c9303ac	21a53d88-27f7-4d6a-8667-cdb3580062eb	g.chr17:38345558C>G	uc010cwu.1	+	5	917	c.427C>G	c.(427-429)Ctt>Gtt	p.L143V	RAPGEFL1_uc010wfd.1_Missense_Mutation_p.L79V	NM_016339	NP_057423	Q9UHV5	RPGFL_HUMAN	Homo sapiens Rap guanine nucleotide exchange factor (GEF)-like 1 (RAPGEFL1), mRNA.	349					G-protein coupled receptor protein signaling pathway|nervous system development|small GTPase mediated signal transduction	intracellular|membrane fraction	guanyl-nucleotide exchange factor activity			breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(2)|lung(5)|ovary(1)|prostate(2)|skin(1)	15						GACGGAGAAACTTCAATATTC	0.552000													54	185					0	0	1	0	0
IGFN1	91156	broad.mit.edu	37	1	201183351	201183351	+	Silent	SNP	G	G	A			TCGA-ET-A3BV-01A-11D-A19J-08	TCGA-ET-A3BV-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a91d8c86-def8-41d7-b05e-d94b9c9303ac	21a53d88-27f7-4d6a-8667-cdb3580062eb	g.chr1:201183351G>A	uc001gwc.3	+	12	8905	c.8775G>A	c.(8773-8775)caG>caA	p.Q2925Q	IGFN1_uc001gwb.3_Non-coding_Transcript	NM_001164586	NP_001158058			Homo sapiens immunoglobulin-like and fibronectin type III domain containing 1 (IGFN1), mRNA.											autonomic_ganglia(2)|cervix(1)|endometrium(3)|kidney(1)|large_intestine(6)|lung(21)|ovary(2)|pancreas(1)|prostate(1)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	45						TGGAAGTGCAGCCGGGGGAGG	0.657000													10	28					0	0	1	0	0
ACSL3	2181	broad.mit.edu	37	2	223789308	223789308	+	Silent	SNP	C	C	T			TCGA-ET-A3BV-01A-11D-A19J-08	TCGA-ET-A3BV-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a91d8c86-def8-41d7-b05e-d94b9c9303ac	21a53d88-27f7-4d6a-8667-cdb3580062eb	g.chr2:223789308C>T	uc002vni.3	+	10	1738	c.1287C>T	c.(1285-1287)tgC>tgT	p.C429C	ACSL3_uc002vnj.3_Silent_p.C429C	NM_004457	NP_976251	O95573	ACSL3_HUMAN	Homo sapiens acyl-CoA synthetase long-chain family member 3 (ACSL3), transcript variant 1, mRNA.	429					long-chain fatty-acyl-CoA biosynthetic process|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane|microsome|mitochondrial outer membrane|peroxisomal membrane	ATP binding|fatty-acyl-CoA synthase activity|long-chain fatty acid-CoA ligase activity|protein binding			cervix(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(5)|ovary(2)|prostate(1)|skin(2)	22		Renal(207;0.0183)		Epithelial(121;1.28e-10)|all cancers(144;8.06e-08)|Lung(261;0.00834)|LUSC - Lung squamous cell carcinoma(224;0.00864)	Icosapent(DB00159)	CTCCACTGTGCGACAGGTAAG	0.323000			T	ETV1	prostate								3	54					0	0	1	0	0
C3orf67	200844	broad.mit.edu	37	3	58849302	58849302	+	Silent	SNP	G	G	T	rs148755922		TCGA-ET-A3BV-01A-11D-A19J-08	TCGA-ET-A3BV-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a91d8c86-def8-41d7-b05e-d94b9c9303ac	21a53d88-27f7-4d6a-8667-cdb3580062eb	g.chr3:58849302G>T	uc003dkt.1	-	11	1609	c.1200C>A	c.(1198-1200)ggC>ggA	p.G400G	C3orf67_uc003dks.1_Silent_p.G215G|AK090895_uc003dku.1_Intron|C3orf67_uc003dkv.1_Silent_p.G215G|C3orf67_uc003dkw.3_Silent_p.G295G	NM_198463	NP_940865	Q6ZVT6	CC067_HUMAN	Homo sapiens chromosome 3 open reading frame 67 (C3orf67), mRNA.	400										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(3)|prostate(2)|skin(1)	19		all_cancers(2;0.000156)|all_epithelial(2;0.000493)|Breast(2;0.00446)|all_lung(2;0.074)|Lung NSC(2;0.248)		BRCA - Breast invasive adenocarcinoma(55;5.93e-06)|Kidney(10;0.00155)|KIRC - Kidney renal clear cell carcinoma(10;0.00172)|OV - Ovarian serous cystadenocarcinoma(275;0.23)		TGCTGTCGCCGCCGTAAAAAT	0.423000													6	35					0	0	1	0	0
TRIP11	9321	broad.mit.edu	37	14	92471796	92471796	+	Missense_Mutation	SNP	C	C	T			TCGA-ET-A3BV-01A-11D-A19J-08	TCGA-ET-A3BV-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a91d8c86-def8-41d7-b05e-d94b9c9303ac	21a53d88-27f7-4d6a-8667-cdb3580062eb	g.chr14:92471796C>T	uc001xzy.3	-	10	2898	c.2524G>A	c.(2524-2526)Gaa>Aaa	p.E842K	TRIP11_uc010auf.2_Missense_Mutation_p.E578K	NM_004239	NP_004230	Q15643	TRIPB_HUMAN	Homo sapiens thyroid hormone receptor interactor 11 (TRIP11), mRNA.	842					transcription from RNA polymerase II promoter	Golgi apparatus|cytoskeleton|membrane|nucleus	protein binding|transcription coactivator activity			breast(3)|central_nervous_system(2)|endometrium(1)|kidney(8)|large_intestine(12)|lung(17)|ovary(7)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	58				COAD - Colon adenocarcinoma(157;0.223)		CTTAAAATTTCATTTTTTCTT	0.333000			T	PDGFRB	AML								5	74					0	0	1	0	0
SRCAP	10847	broad.mit.edu	37	16	30744989	30744989	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A3BV-01A-11D-A19J-08	TCGA-ET-A3BV-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a91d8c86-def8-41d7-b05e-d94b9c9303ac	21a53d88-27f7-4d6a-8667-cdb3580062eb	g.chr16:30744989G>A	uc002dze.1	+	28	6749	c.6364G>A	c.(6364-6366)Ggt>Agt	p.G2122S	SRCAP_uc002dzf.3_Non-coding_Transcript|SRCAP_uc002dzg.1_Missense_Mutation_p.G1917S	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Homo sapiens Snf2-related CREBBP activator protein (SRCAP), mRNA.	2122	Helicase C-terminal.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			NS(1)|breast(3)|cervix(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(22)|liver(3)|lung(62)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(5)	136			Colorectal(24;0.198)			TCGGAGTGGGGGTGTGGGCGT	0.502000													10	114					0	0	1	0	0
SPTBN2	6712	broad.mit.edu	37	11	66472833	66472833	+	Silent	SNP	C	C	T			TCGA-ET-A3BV-01A-11D-A19J-08	TCGA-ET-A3BV-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a91d8c86-def8-41d7-b05e-d94b9c9303ac	21a53d88-27f7-4d6a-8667-cdb3580062eb	g.chr11:66472833C>T	uc001ojd.3	-	13	1986	c.1914G>A	c.(1912-1914)gaG>gaA	p.E638E		NM_006946	NP_008877	O15020	SPTN2_HUMAN	Homo sapiens spectrin, beta, non-erythrocytic 2 (SPTBN2), mRNA.	638					actin filament capping|axon guidance|cell death|vesicle-mediated transport	cytosol|spectrin	actin binding|structural constituent of cytoskeleton			autonomic_ganglia(1)|breast(1)|central_nervous_system(4)|cervix(1)|endometrium(10)|kidney(5)|large_intestine(15)|liver(1)|lung(22)|ovary(2)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(1)	74						GCCGTGATTCCTCCAGCCGGG	0.697000													5	33					0	0	1	0	0
CHI3L1	1116	broad.mit.edu	37	1	203148632	203148632	+	Missense_Mutation	SNP	C	C	G			TCGA-ET-A3BV-01A-11D-A19J-08	TCGA-ET-A3BV-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a91d8c86-def8-41d7-b05e-d94b9c9303ac	21a53d88-27f7-4d6a-8667-cdb3580062eb	g.chr1:203148632C>G	uc001gzi.2	-	9	1264	c.1093G>C	c.(1093-1095)Ggc>Cgc	p.G365R	CHI3L1_uc001gzk.1_3'UTR|CHI3L1_uc001gzj.2_Missense_Mutation_p.G304R|CHI3L1_uc001gzl.3_5'Flank	NM_001276	NP_001267	P36222	CH3L1_HUMAN	Homo sapiens chitinase 3-like 1 (cartilage glycoprotein-39) (CHI3L1), mRNA.	365					chitin catabolic process	extracellular space|proteinaceous extracellular matrix	cation binding|chitinase activity|extracellular matrix structural constituent|sugar binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(3)|ovary(1)|pancreas(1)|skin(1)	18						AGATCCTGGCCACAGAAGGAG	0.637000													4	65					0	0	1	0	0
MTBP	27085	broad.mit.edu	37	8	121457748	121457748	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A3BV-01A-11D-A19J-08	TCGA-ET-A3BV-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a91d8c86-def8-41d7-b05e-d94b9c9303ac	21a53d88-27f7-4d6a-8667-cdb3580062eb	g.chr8:121457748G>A	uc003ypc.1	+	0	83	c.38G>A	c.(37-39)gGa>gAa	p.G13E	MRPL13_uc003ypa.3_5'Flank|MRPL13_uc010mdf.3_5'Flank|MTBP_uc003ypb.1_Missense_Mutation_p.G13E|MTBP_uc011lie.1_Non-coding_Transcript	NM_022045	NP_071328	Q96DY7	MTBP_HUMAN	Homo sapiens Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa (MTBP), mRNA.	13					cell cycle arrest					NS(1)|breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	30	Lung NSC(37;5.68e-08)|Ovarian(258;0.00769)|all_neural(195;0.0804)|Hepatocellular(40;0.161)		STAD - Stomach adenocarcinoma(47;0.00503)			TGGGGGGAAGGAAAATTCCCG	0.582000													11	89					0	0	1	0	0
UBN1	29855	broad.mit.edu	37	16	4924499	4924499	+	Silent	SNP	T	T	G			TCGA-ET-A3BV-01A-11D-A19J-08	TCGA-ET-A3BV-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a91d8c86-def8-41d7-b05e-d94b9c9303ac	21a53d88-27f7-4d6a-8667-cdb3580062eb	g.chr16:4924499T>G	uc002cyb.3	+	14	2427	c.2088T>G	c.(2086-2088)ccT>ccG	p.P696P	UBN1_uc010uxw.2_Silent_p.P696P|UBN1_uc002cyc.3_Silent_p.P696P	NM_001079514	NP_058632	Q9NPG3	UBN1_HUMAN	Homo sapiens ubinuclein 1 (UBN1), transcript variant 2, mRNA.	696					chromatin modification|interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter	PML body|tight junction	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(6)|kidney(4)|large_intestine(10)|lung(12)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38						TCACACTGCCTGCACCCTCAA	0.498000													26	266					0	0	1	0	0
PTPN21	11099	broad.mit.edu	37	14	88945377	88945377	+	Missense_Mutation	SNP	C	C	G			TCGA-ET-A3BV-01A-11D-A19J-08	TCGA-ET-A3BV-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a91d8c86-def8-41d7-b05e-d94b9c9303ac	21a53d88-27f7-4d6a-8667-cdb3580062eb	g.chr14:88945377C>G	uc001xwv.4	-	12	2729	c.2398G>C	c.(2398-2400)Gac>Cac	p.D800H	PTPN21_uc010twc.2_Missense_Mutation_p.D596H	NM_007039	NP_008970	Q16825	PTN21_HUMAN	Homo sapiens protein tyrosine phosphatase, non-receptor type 21 (PTPN21), mRNA.	800						cytoplasm|cytoskeleton	binding|protein tyrosine phosphatase activity			breast(1)|central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(13)|liver(1)|lung(7)|ovary(4)|prostate(3)|skin(6)|upper_aerodigestive_tract(1)|urinary_tract(1)	45						GTGGTGAGGTCGGACTCCGAC	0.647000													8	62					0	0	1	0	0
OTOP3	347741	broad.mit.edu	37	17	72938090	72938090	+	Silent	SNP	C	C	T			TCGA-ET-A3BV-01A-11D-A19J-08	TCGA-ET-A3BV-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a91d8c86-def8-41d7-b05e-d94b9c9303ac	21a53d88-27f7-4d6a-8667-cdb3580062eb	g.chr17:72938090C>T	uc010wrr.2	+	2	585	c.585C>T	c.(583-585)gaC>gaT	p.D195D	OTOP3_uc010wrq.2_Silent_p.D177D	NM_178233	NP_839947	Q7RTS5	OTOP3_HUMAN	Homo sapiens otopetrin 3 (OTOP3), mRNA.	195						integral to membrane|intracellular	zinc ion binding			breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	23	all_lung(278;0.151)|Lung NSC(278;0.185)					CACAGCTGGACCTTGTCTTCT	0.567000													4	41					0	0	1	0	0
SGK223	157285	broad.mit.edu	37	8	8176174	8176174	+	Silent	SNP	G	G	A			TCGA-ET-A3BV-01A-11D-A19J-08	TCGA-ET-A3BV-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a91d8c86-def8-41d7-b05e-d94b9c9303ac	21a53d88-27f7-4d6a-8667-cdb3580062eb	g.chr8:8176174G>A	uc003wsh.4	-	4	3711	c.3711C>T	c.(3709-3711)ccC>ccT	p.P1237P		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	Homo sapiens homolog of rat pragma of Rnd2 (SGK223), mRNA.	1237	Protein kinase.						ATP binding|non-membrane spanning protein tyrosine kinase activity										ACACGATCTCGGGGGCCAGCC	0.612000													3	30					0	0	1	0	0
THEG	51298	broad.mit.edu	37	19	371211	371211	+	Missense_Mutation	SNP	C	C	T			TCGA-ET-A3BV-01A-11D-A19J-08	TCGA-ET-A3BV-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a91d8c86-def8-41d7-b05e-d94b9c9303ac	21a53d88-27f7-4d6a-8667-cdb3580062eb	g.chr19:371211C>T	uc002lol.3	-	5	790	c.747G>A	c.(745-747)atG>atA	p.M249I	THEG_uc002lom.3_Missense_Mutation_p.M225I	NM_016585	NP_057669	Q9P2T0	THEG_HUMAN	Homo sapiens Theg homolog (mouse) (THEG), transcript variant 1, mRNA.	249					cell differentiation|chaperone-mediated protein complex assembly|multicellular organismal development|spermatogenesis	nucleus	protein binding	p.P248L(1)		NS(1)|breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(6)|lung(9)|ovary(1)|prostate(1)|skin(2)|soft_tissue(1)	29		all_cancers(10;1.13e-36)|all_epithelial(18;1.46e-23)|Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.1e-06)|all_lung(49;1.55e-06)|Breast(49;4.08e-05)|Hepatocellular(1079;0.137)|Renal(1328;0.228)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CCACCTCAGACATGGGCATGC	0.642000													26	147					0	0	1	0	0
CDC42	998	broad.mit.edu	37	1	22412941	22412941	+	Missense_Mutation	SNP	A	A	T			TCGA-ET-A3BV-01A-11D-A19J-08	TCGA-ET-A3BV-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a91d8c86-def8-41d7-b05e-d94b9c9303ac	21a53d88-27f7-4d6a-8667-cdb3580062eb	g.chr1:22412941A>T	uc010odr.2	+	4	489	c.323A>T	c.(322-324)gAt>gTt	p.D108V	CDC42_uc009vqg.1_Missense_Mutation_p.D63V|CDC42_uc001bfp.3_Missense_Mutation_p.D63V|CDC42_uc009vqh.3_Missense_Mutation_p.D22V|CDC42_uc001bfq.3_Missense_Mutation_p.D63V|CDC42_uc001bfr.3_Missense_Mutation_p.D63V|CDC42_uc010ods.2_Missense_Mutation_p.D105V	NM_001039802	NP_001782	P60953	CDC42_HUMAN	Homo sapiens cell division cycle 42 (GTP binding protein, 25kDa) (CDC42), transcript variant 3, mRNA.	63					T cell costimulation|actin cytoskeleton organization|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|establishment or maintenance of cell polarity|macrophage differentiation|muscle cell differentiation|negative regulation of epidermal growth factor receptor signaling pathway|negative regulation of protein complex assembly|positive regulation of muscle cell differentiation|positive regulation of pseudopodium assembly|regulation of filopodium assembly|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|plasma membrane	GTP binding|GTPase activity|protein binding|thioesterase binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(1)|lung(4)	12		Colorectal(325;3.46e-05)|all_lung(284;5.94e-05)|Lung NSC(340;6.55e-05)|Renal(390;0.000219)|Breast(348;0.00222)|Ovarian(437;0.00308)|Myeloproliferative disorder(586;0.0255)|Prostate(1639;0.0792)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0452)|OV - Ovarian serous cystadenocarcinoma(117;7.32e-26)|Colorectal(126;1.35e-07)|COAD - Colon adenocarcinoma(152;7.73e-06)|GBM - Glioblastoma multiforme(114;8.62e-06)|BRCA - Breast invasive adenocarcinoma(304;0.000649)|STAD - Stomach adenocarcinoma(196;0.00644)|KIRC - Kidney renal clear cell carcinoma(1967;0.00767)|READ - Rectum adenocarcinoma(331;0.0419)|Lung(427;0.207)		GGGCAAGAGGATTATGACAGA	0.373000													14	69					0	0	1	0	0
VMO1	284013	broad.mit.edu	37	17	4689488	4689488	+	Missense_Mutation	SNP	G	G	A	rs147226483		TCGA-ET-A3BV-01A-11D-A19J-08	TCGA-ET-A3BV-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a91d8c86-def8-41d7-b05e-d94b9c9303ac	21a53d88-27f7-4d6a-8667-cdb3580062eb	g.chr17:4689488G>A	uc002fyx.3	-	0	242	c.160C>T	c.(160-162)Ccc>Tcc	p.P54S	VMO1_uc010vsh.2_Missense_Mutation_p.P54S|VMO1_uc010vsi.2_Missense_Mutation_p.P54S|VMO1_uc002fyy.3_Missense_Mutation_p.P54S|GLTPD2_uc002fza.2_5'Flank	NM_182566	NP_872372	Q7Z5L0	VMO1_HUMAN	Homo sapiens vitelline membrane outer layer 1 homolog (chicken) (VMO1), transcript variant 1, mRNA.	54					vitelline membrane formation	extracellular region				kidney(2)|large_intestine(3)|liver(1)|lung(3)|ovary(1)|pancreas(1)	11						AATCCATCGGGACACATCTCA	0.622000													8	32					0	0	1	0	0
DLG5	9231	broad.mit.edu	37	10	79581669	79581669	+	Missense_Mutation	SNP	G	G	T			TCGA-ET-A3BV-01A-11D-A19J-08	TCGA-ET-A3BV-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a91d8c86-def8-41d7-b05e-d94b9c9303ac	21a53d88-27f7-4d6a-8667-cdb3580062eb	g.chr10:79581669G>T	uc001jzk.3	-	14	2643	c.2573C>A	c.(2572-2574)cCa>cAa	p.P858Q	DLG5_uc001jzi.3_5'Flank|DLG5_uc001jzj.3_Intron|DLG5_uc009xru.1_Non-coding_Transcript|DLG5_uc001jzl.4_Missense_Mutation_p.P462Q	NM_004747	NP_004738	Q8TDM6	DLG5_HUMAN	Homo sapiens discs, large homolog 5 (Drosophila) (DLG5), mRNA.	858					cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			TGGGGGGCCTGGCTCCTTCCT	0.592000													10	94					0	0	1	0	0
ZNF585B	92285	broad.mit.edu	37	19	37676134	37676134	+	Missense_Mutation	SNP	C	C	G			TCGA-ET-A3BV-01A-11D-A19J-08	TCGA-ET-A3BV-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a91d8c86-def8-41d7-b05e-d94b9c9303ac	21a53d88-27f7-4d6a-8667-cdb3580062eb	g.chr19:37676134C>G	uc002ofq.3	-	4	2557	c.2305G>C	c.(2305-2307)Gct>Cct	p.A769P	ZNF585B_uc002ofr.1_Missense_Mutation_p.A583P	NM_152279	NP_689492	Q52M93	Z585B_HUMAN	Homo sapiens zinc finger protein 585B (ZNF585B), mRNA.	769					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)	29			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			TTCTCTCAAGCGTGGCTGCTC	0.448000													8	91					0	0	1	0	0
SPAG9	9043	broad.mit.edu	37	17	49052246	49052246	+	Missense_Mutation	SNP	C	C	G			TCGA-ET-A3BV-01A-11D-A19J-08	TCGA-ET-A3BV-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a91d8c86-def8-41d7-b05e-d94b9c9303ac	21a53d88-27f7-4d6a-8667-cdb3580062eb	g.chr17:49052246C>G	uc002itc.3	-	27	3795	c.3586G>C	c.(3586-3588)Gaa>Caa	p.E1196Q	SPAG9_uc002itd.3_Missense_Mutation_p.E1186Q|SPAG9_uc002itb.3_Missense_Mutation_p.E1182Q|SPAG9_uc002ita.3_Missense_Mutation_p.E1052Q	NM_001130528	NP_001124000	O60271	JIP4_HUMAN	Homo sapiens sperm associated antigen 9 (SPAG9), transcript variant 1, mRNA.	1196					positive regulation of cell migration|positive regulation of muscle cell differentiation|retrograde transport, endosome to Golgi|spermatogenesis	acrosomal vesicle|integral to membrane|perinuclear region of cytoplasm				NS(1)|breast(3)|endometrium(3)|kidney(4)|large_intestine(8)|lung(14)|ovary(1)|prostate(1)|skin(1)|stomach(1)	37			BRCA - Breast invasive adenocarcinoma(22;4.24e-07)			TCACTGTTTTCATCACCATAT	0.418000													5	61					0	0	1	0	0
TFPI	7035	broad.mit.edu	37	2	188332580	188332580	+	Silent	SNP	A	A	G			TCGA-ET-A3BV-01A-11D-A19J-08	TCGA-ET-A3BV-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a91d8c86-def8-41d7-b05e-d94b9c9303ac	21a53d88-27f7-4d6a-8667-cdb3580062eb	g.chr2:188332580A>G	uc002upy.3	-	6	1003	c.708T>C	c.(706-708)aaT>aaC	p.N236N		NM_006287	NP_006278	P10646	TFPI1_HUMAN	Homo sapiens tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) (TFPI), transcript variant 1, mRNA.	236	BPTI/Kunitz inhibitor 3.				blood coagulation, extrinsic pathway	extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			breast(1)|endometrium(1)|kidney(1)|large_intestine(3)|lung(2)|skin(1)	9			OV - Ovarian serous cystadenocarcinoma(117;0.0554)		Coagulation factor VIIa(DB00036)	CAATGACTGAATTGTAGTAGA	0.413000													17	69					0	0	1	0	0
CHEK1	1111	broad.mit.edu	37	11	125513996	125513996	+	Missense_Mutation	SNP	G	G	A	rs34097480		TCGA-ET-A3BV-01A-11D-A19J-08	TCGA-ET-A3BV-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a91d8c86-def8-41d7-b05e-d94b9c9303ac	21a53d88-27f7-4d6a-8667-cdb3580062eb	g.chr11:125513996G>A	uc010sbh.2	+	8	1607	c.982G>A	c.(982-984)Gtg>Atg	p.V328M	CHEK1_uc009zbo.3_Missense_Mutation_p.V312M|CHEK1_uc010sbi.2_Missense_Mutation_p.V312M|CHEK1_uc001qcf.4_Missense_Mutation_p.V312M|CHEK1_uc009zbp.3_Missense_Mutation_p.V312M|CHEK1_uc001qcg.4_Missense_Mutation_p.V312M			O14757	CHK1_HUMAN	Homo sapiens checkpoint kinase 1 (CHEK1), transcript variant 5, non-coding RNA.	312					DNA repair|DNA replication|cellular response to mechanical stimulus|gamete generation|negative regulation of cell proliferation|reciprocal meiotic recombination|regulation of cyclin-dependent protein kinase activity|replicative senescence	condensed nuclear chromosome|microtubule organizing center|nucleoplasm	ATP binding|protein binding|protein serine/threonine kinase activity	p.W328L(1)		central_nervous_system(3)|endometrium(3)|large_intestine(2)|lung(16)|skin(1)|upper_aerodigestive_tract(1)	26	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0748)		TGAAGAAAATGTGAAGTACTC	0.388000								Other conserved DNA damage response genes					8	96					0	0	1	0	0
IMPDH2	3615	broad.mit.edu	37	3	49064023	49064023	+	Missense_Mutation	SNP	G	G	C			TCGA-ET-A3BV-01A-11D-A19J-08	TCGA-ET-A3BV-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a91d8c86-def8-41d7-b05e-d94b9c9303ac	21a53d88-27f7-4d6a-8667-cdb3580062eb	g.chr3:49064023G>C	uc003cvt.3	-	7	931	c.839C>G	c.(838-840)tCc>tGc	p.S280C		NM_000884	NP_000875	P12268	IMDH2_HUMAN	Homo sapiens IMP (inosine 5'-monophosphate) dehydrogenase 2 (IMPDH2), mRNA.	280					GMP biosynthetic process|purine base metabolic process	cytosol|nucleus	IMP dehydrogenase activity|metal ion binding|nucleotide binding|protein binding			breast(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(2)|stomach(1)|urinary_tract(1)	16				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)	Mycophenolate mofetil(DB00688)|Mycophenolic acid(DB01024)|NADH(DB00157)	CTGGAAGATGGAATTTCCCTG	0.468000													5	78					0	0	1	0	0
POSTN	10631	broad.mit.edu	37	13	38166263	38166263	+	Missense_Mutation	SNP	A	A	G			TCGA-ET-A3BV-01A-11D-A19J-08	TCGA-ET-A3BV-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a91d8c86-def8-41d7-b05e-d94b9c9303ac	21a53d88-27f7-4d6a-8667-cdb3580062eb	g.chr13:38166263A>G	uc001uwo.4	-	2	375	c.257T>C	c.(256-258)aTg>aCg	p.M86T	POSTN_uc001uwp.4_Missense_Mutation_p.M86T|POSTN_uc001uwr.3_Missense_Mutation_p.M86T|POSTN_uc001uwq.3_Missense_Mutation_p.M86T|POSTN_uc010teu.1_Missense_Mutation_p.M86T|POSTN_uc010tev.1_Missense_Mutation_p.M86T|POSTN_uc010tew.1_Missense_Mutation_p.M86T|POSTN_uc010tex.1_Missense_Mutation_p.M1T	NM_006475	NP_006466	Q15063	POSTN_HUMAN	Homo sapiens periostin, osteoblast specific factor (POSTN), transcript variant 1, mRNA.	86	EMI.				cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(16)|lung(22)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	59		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		CATTCCTTCCATTCTCATATA	0.333000													4	45					0	0	1	0	0
CTDP1	9150	broad.mit.edu	37	18	77474796	77474796	+	Missense_Mutation	SNP	A	A	G			TCGA-ET-A3BV-01A-11D-A19J-08	TCGA-ET-A3BV-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a91d8c86-def8-41d7-b05e-d94b9c9303ac	21a53d88-27f7-4d6a-8667-cdb3580062eb	g.chr18:77474796A>G	uc002lnh.2	+	7	1483	c.1336A>G	c.(1336-1338)Acg>Gcg	p.T446A	CTDP1_uc002lni.2_Missense_Mutation_p.T446A|CTDP1_uc010drd.2_Missense_Mutation_p.T446A|CTDP1_uc021ult.1_Missense_Mutation_p.T327A	NM_004715	NP_001189433	Q9Y5B0	CTDP1_HUMAN	Homo sapiens CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1 (CTDP1), transcript variant 1, mRNA.	446					positive regulation of viral transcription|protein dephosphorylation|transcription elongation from RNA polymerase II promoter|viral reproduction	nucleoplasm	CTD phosphatase activity|DNA-directed RNA polymerase activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|prostate(2)|urinary_tract(1)	35		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;5.2e-06)|BRCA - Breast invasive adenocarcinoma(31;0.0277)		CCAGGGTGCCACGGGCACTGA	0.677000													4	8					0	0	1	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	A	T	rs121913377		TCGA-ET-A3BV-01A-11D-A19J-08	TCGA-ET-A3BV-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a91d8c86-def8-41d7-b05e-d94b9c9303ac	21a53d88-27f7-4d6a-8667-cdb3580062eb	g.chr7:140453136A>T	uc003vwc.4	-	14	1860	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	Homo sapiens v-raf murine sarcoma viral oncogene homolog B1 (BRAF), mRNA.	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(41204)|p.V600K(615)|p.V600?(377)|p.V600R(99)|p.V600D(40)|p.V600_K601>E(30)|p.V600L(28)|p.V600A(24)|p.V600G(22)|p.V600M(22)|p.A598_T599insV(7)|p.T599_V600insT(7)|p.T599I(5)|p.V600Q(4)|p.T599_R603>I(4)|p.T599_V600insTT(3)|p.T599_V600insDFGLAT(2)|p.T599_V600>IAL(2)|p.V600_S605>EK(2)|p.T599T(2)|p.V600_S605>DV(2)|p.V600_S605>D(2)|p.V600_W604del(1)|p.V600V(1)|p.T599_V600insV(1)|p.V600>DLAT(1)|p.D594_T599del(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome				16	56					0	0	1	0	0
ARHGAP26	23092	broad.mit.edu	37	5	142393652	142393652	+	Missense_Mutation	SNP	A	A	C			TCGA-ET-A3BV-01A-11D-A19J-08	TCGA-ET-A3BV-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a91d8c86-def8-41d7-b05e-d94b9c9303ac	21a53d88-27f7-4d6a-8667-cdb3580062eb	g.chr5:142393652A>C	uc011dbj.2	+	11	1150	c.1115A>C	c.(1114-1116)aAc>aCc	p.N372T	ARHGAP26_uc003lmt.3_Missense_Mutation_p.N372T|ARHGAP26_uc003lmw.3_Missense_Mutation_p.N372T	NM_015071	NP_055886	Q9UNA1	RHG26_HUMAN	Homo sapiens Rho GTPase activating protein 26 (ARHGAP26), transcript variant 1, mRNA.	372					actin cytoskeleton organization|filopodium assembly|nervous system development|small GTPase mediated signal transduction	cytoskeleton|cytosol|focal adhesion	Rho GTPase activator activity|SH3 domain binding|cytoskeletal adaptor activity			autonomic_ganglia(1)|breast(1)|central_nervous_system(2)|endometrium(4)|kidney(3)|large_intestine(6)|lung(7)|ovary(1)	25		all_hematologic(541;0.0416)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CAGGTCTACAACTCGAACAAA	0.423000													15	53					0	0	1	0	0
MGAT5B	146664	broad.mit.edu	37	17	74869018	74869018	+	Missense_Mutation	SNP	G	G	A			TCGA-ET-A3BV-01A-11D-A19J-08	TCGA-ET-A3BV-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a91d8c86-def8-41d7-b05e-d94b9c9303ac	21a53d88-27f7-4d6a-8667-cdb3580062eb	g.chr17:74869018G>A	uc002jti.3	+	0	290	c.187G>A	c.(187-189)Gac>Aac	p.D63N	MGAT5B_uc002jtg.4_Missense_Mutation_p.D52N|MGAT5B_uc002jth.3_Missense_Mutation_p.D52N	NM_198955	NP_945193	Q3V5L5	MGT5B_HUMAN	Homo sapiens mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B (MGAT5B), transcript variant 2, mRNA.	52						Golgi membrane|integral to membrane	alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity|metal ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(2)|lung(15)|ovary(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	29						GCGCCTGGGGGACTCGCCATT	0.602000													16	78					0	0	1	0	0
OR5AR1	219493	broad.mit.edu	37	11	56431736	56431736	+	Missense_Mutation	SNP	C	C	A			TCGA-ET-A3BV-01A-11D-A19J-08	TCGA-ET-A3BV-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a91d8c86-def8-41d7-b05e-d94b9c9303ac	21a53d88-27f7-4d6a-8667-cdb3580062eb	g.chr11:56431736C>A	uc010rjm.2	+	0	575	c.575C>A	c.(574-576)aCc>aAc	p.T192N	OR8U8_uc001nit.2_Intron	NM_001004730	NP_001004730	Q8NGP9	O5AR1_HUMAN	Homo sapiens olfactory receptor, family 5, subfamily AR, member 1 (OR5AR1), mRNA.	192					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(1)|lung(12)|prostate(1)|skin(3)|stomach(1)	26						TGCTCAGACACCTACATCAGT	0.453000													22	150					0	0	1	0	0
TGOLN2	10618	broad.mit.edu	37	2	85552043	85552043	+	Frame_Shift_Del	DEL	G	G	-			TCGA-ET-A3BV-01A-11D-A19J-08	TCGA-ET-A3BV-10A-01D-A19M-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	a91d8c86-def8-41d7-b05e-d94b9c9303ac	21a53d88-27f7-4d6a-8667-cdb3580062eb	g.chr2:85552043delG	uc021vjw.1	-	2	1637	c.1303delC	c.(1303-1305)cagfs	p.Q435fs	TGOLN2_uc002spb.3_Frame_Shift_Del_p.Q377fs|TGOLN2_uc002soz.3_Frame_Shift_Del_p.Q435fs|TGOLN2_uc021vjx.1_Frame_Shift_Del_p.Q435fs|TGOLN2_uc002spa.3_Non-coding_Transcript|TGOLN2_uc002spc.2_Frame_Shift_Del_p.Q435fs	NM_001206840	NP_001193769	O43493	TGON2_HUMAN	Homo sapiens trans-golgi network protein 2 (TGOLN2), transcript variant 2, mRNA.	435						integral to membrane|nucleus|plasma membrane|trans-Golgi network|transport vesicle	protein binding										CTTACCTTCTGGTCCAAACGT	0.502													2	4	---	---	---	---					
