Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
PPP2R5E	5529	broad.mit.edu	37	14	63858584	63858584	+	Splice_Site	SNP	A	A	G			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr14:63858584A>G	ENST00000337537.3	-	10	1507	c.903_splice	c.e10-1	p.V302_splice	PPP2R5E_ENST00000553266.1_5'UTR|PPP2R5E_ENST00000422769.2_Splice_Site_p.V226_splice|PPP2R5E_ENST00000555899.1_Splice_Site_p.V302_splice	NM_006246.2	NP_006237.1	Q16537	2A5E_HUMAN	protein phosphatase 2, regulatory subunit B', epsilon isoform	302					signal transduction	cytoplasm|intracellular membrane-bounded organelle|protein phosphatase type 2A complex	protein binding|protein phosphatase type 2A regulator activity			endometrium(1)|large_intestine(2)|lung(5)|ovary(1)|pancreas(1)|prostate(3)|skin(1)|soft_tissue(1)	15				OV - Ovarian serous cystadenocarcinoma(108;0.00197)|all cancers(60;0.0153)|BRCA - Breast invasive adenocarcinoma(234;0.128)		CCCCCTAATAACCTAAAATGA	0.299000													13	40					0	0	1	0	0
FAM65A	79567	broad.mit.edu	37	16	67579900	67579900	+	Nonsense_Mutation	SNP	C	C	T			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr16:67579900C>T	ENST00000540839.3	+	21	3713	c.3493C>T	c.(3493-3495)Cga>Tga	p.R1165*	FAM65A_ENST00000379312.3_Nonsense_Mutation_p.R1150*|FAM65A_ENST00000428437.2_Nonsense_Mutation_p.R1160*|FAM65A_ENST00000422602.2_Nonsense_Mutation_p.R1166*|FAM65A_ENST00000042381.4_Nonsense_Mutation_p.R1146*			Q6ZS17	FA65A_HUMAN	family with sequence similarity 65, member A	1150						cytoplasm	binding			central_nervous_system(2)|endometrium(3)|kidney(2)|large_intestine(12)|lung(12)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(1)	39		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0474)|Epithelial(162;0.117)		CGTGCAGACTCGAGTGGCTGG	0.657000													57	37					0	0	1	0	0
MYPN	84665	broad.mit.edu	37	10	69918245	69918245	+	Missense_Mutation	SNP	G	G	T			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr10:69918245G>T	ENST00000358913.5	+	7	1808	c.1320G>T	c.(1318-1320)atG>atT	p.M440I	MYPN_ENST00000373675.3_Missense_Mutation_p.M440I|MYPN_ENST00000540630.1_Missense_Mutation_p.M440I|MYPN_ENST00000354393.2_Missense_Mutation_p.M165I	NM_001256267.1|NM_032578.3	NP_001243196.1|NP_115967.2	Q86TC9	MYPN_HUMAN	myopalladin	440	Ig-like 2.|Interaction with CARP.					nucleus|sarcomere	actin binding			breast(2)|central_nervous_system(1)|endometrium(13)|kidney(6)|large_intestine(13)|liver(1)|lung(43)|ovary(3)|prostate(1)|skin(6)|upper_aerodigestive_tract(5)	94						CATTATAGATGCTACAAAATT	0.363000													4	37					0.000602214	0.000634476	1	1	0
MTIF2	4528	broad.mit.edu	37	2	55463904	55463904	+	Silent	SNP	C	C	A	rs138084091	byFrequency	TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr2:55463904C>A	ENST00000394600.3	-	17	2800	c.2064G>T	c.(2062-2064)acG>acT	p.T688T	MTIF2_ENST00000263629.4_Silent_p.T688T|MTIF2_ENST00000403721.1_Silent_p.T688T	NM_001005369.1	NP_001005369.1	P46199	IF2M_HUMAN	mitochondrial translational initiation factor 2	688					regulation of translational initiation	mitochondrion	GTP binding|GTPase activity|ribosomal small subunit binding|translation initiation factor activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(5)|ovary(1)|prostate(1)|skin(1)|stomach(2)|upper_aerodigestive_tract(2)	24						AATCCATTCCCGTTTTGACAA	0.313000													5	17					0.184627	0.184627	1	1	0
PTPRA	0	broad.mit.edu	37	20	2985712	2985712	+	Missense_Mutation	SNP	C	C	T			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr20:2985712C>T	ENST00000216877.6	+	9	1122	c.722C>T	c.(721-723)gCa>gTa	p.A241V	PTPRA_ENST00000425918.2_Missense_Mutation_p.A261V|PTPRA_ENST00000399903.2_Missense_Mutation_p.A250V|PTPRA_ENST00000380393.3_Missense_Mutation_p.A250V|PTPRA_ENST00000358719.4_Missense_Mutation_p.A106V|PTPRA_ENST00000318266.5_Missense_Mutation_p.A241V|PTPRA_ENST00000356147.3_Missense_Mutation_p.A241V	NM_080840.2	NP_543030.1	P18433	PTPRA_HUMAN	protein tyrosine phosphatase, receptor type, A	250	Tyrosine-protein phosphatase 1.				axon guidance|protein phosphorylation	integral to plasma membrane	transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(1)|endometrium(3)|large_intestine(3)|lung(5)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	17						GCTCTCCCTGCATGTCCTATC	0.438000													5	244					0	0	1	0	0
NELFCD	51497	broad.mit.edu	37	20	57564966	57564966	+	Silent	SNP	C	C	T			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr20:57564966C>T	ENST00000602795.1	+	7	813	c.765C>T	c.(763-765)tcC>tcT	p.S255S	NELFCD_ENST00000344018.3_Silent_p.S246S					negative elongation factor complex member C/D																		CCATGATGTCCGTGCTGGCCC	0.617000													24	102					0	0	1	0	0
INADL	10207	broad.mit.edu	37	1	62582864	62582864	+	Missense_Mutation	SNP	G	G	A			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr1:62582864G>A	ENST00000371158.2	+	37	4978	c.4864G>A	c.(4864-4866)Gca>Aca	p.A1622T	INADL_ENST00000543708.1_Missense_Mutation_p.A436T	NM_176877.2	NP_795352.2	Q8NI35	INADL_HUMAN	InaD-like (Drosophila)	1622					intracellular signal transduction|tight junction assembly	apical plasma membrane|perinuclear region of cytoplasm|tight junction	protein binding			breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(11)|large_intestine(8)|liver(1)|lung(51)|ovary(3)|pancreas(1)|prostate(7)|skin(5)|stomach(1)|upper_aerodigestive_tract(3)	103						CTGGACCTCCGCAAGGACGAC	0.483000													3	30					0	0	1	0	0
SMARCA5	8467	broad.mit.edu	37	4	144445586	144445586	+	Silent	SNP	C	C	T			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr4:144445586C>T	ENST00000283131.3	+	4	948	c.486C>T	c.(484-486)acC>acT	p.T162T		NM_003601.3	NP_003592.3	O60264	SMCA5_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	162					CenH3-containing nucleosome assembly at centromere|nucleosome positioning|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	condensed chromosome|nucleolus|nucleoplasm|NURF complex|RSF complex	ATP binding|ATPase activity|DNA binding|helicase activity|nucleosome binding|protein binding		EWSR1/SMARCA5(2)	endometrium(2)|kidney(2)|large_intestine(9)|lung(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21	all_hematologic(180;0.158)					CCAAAGCAACCAATGTTTGCA	0.363000													12	25					0	0	1	0	0
HMGB3	3149	broad.mit.edu	37	X	150156360	150156360	+	Silent	SNP	G	G	A			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chrX:150156360G>A	ENST00000325307.7	+	5	672	c.576G>A	c.(574-576)gaG>gaA	p.E192E	HMGB3_ENST00000448905.2_Silent_p.E192E	NM_005342.2	NP_005333.2	O15347	HMGB3_HUMAN	high mobility group box 3	192	Asp/Glu-rich (acidic).				DNA recombination|multicellular organismal development	chromosome|nucleus	DNA bending activity|double-stranded DNA binding	p.E192E(1)		endometrium(3)|large_intestine(2)|lung(2)|skin(1)	8	Acute lymphoblastic leukemia(192;6.56e-05)					aggaagaagaggaggaggagg	0.443000													3	31					0	0	1	0	0
RCSD1	92241	broad.mit.edu	37	1	167663457	167663457	+	Missense_Mutation	SNP	G	G	A			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr1:167663457G>A	ENST00000367854.3	+	5	723	c.392G>A	c.(391-393)cGa>cAa	p.R131Q	RCSD1_ENST00000537350.1_Missense_Mutation_p.R101Q	NM_052862.3	NP_443094.3	Q6JBY9	CPZIP_HUMAN	RCSD domain containing 1	131										NS(1)|breast(3)|central_nervous_system(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(6)|lung(2)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	24	all_hematologic(923;0.215)					CCTGGTGTGCGATCTAGGCCC	0.592000													9	84					0	0	1	0	0
RPRD2	23248	broad.mit.edu	37	1	150444176	150444176	+	Missense_Mutation	SNP	G	G	A			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr1:150444176G>A	ENST00000401000.4	+	10	2739	c.2674G>A	c.(2674-2676)Gta>Ata	p.V892I	RPRD2_ENST00000539519.1_Missense_Mutation_p.V892I|RPRD2_ENST00000492220.1_3'UTR|RPRD2_ENST00000369068.4_Missense_Mutation_p.V918I			Q5VT52	RPRD2_HUMAN	regulation of nuclear pre-mRNA domain containing 2	918	Ser-rich.						protein binding			central_nervous_system(1)|endometrium(2)|kidney(4)|large_intestine(4)|lung(20)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	37						TGCCTTCAGCGTAAGAGGGAA	0.507000													5	367					0	0	1	0	0
TM9SF1	10548	broad.mit.edu	37	14	24679649	24679649	+	Missense_Mutation	SNP	T	T	A			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr14:24679649T>A	ENST00000556387.1	-	5	548	c.515A>T	c.(514-516)gAa>gTa	p.E172V	AL136419.6_ENST00000565988.1_RNA|CHMP4A_ENST00000542700.2_5'UTR|CHMP4A_ENST00000347519.6_Missense_Mutation_p.E215V|TM9SF1_ENST00000530611.1_Missense_Mutation_p.E172V			O15321	TM9S1_HUMAN	transmembrane 9 superfamily member 1	0					autophagy	autophagic vacuole membrane|cytoplasmic vesicle|integral to membrane|lysosomal membrane				NS(1)|breast(4)|endometrium(3)|large_intestine(11)|lung(4)|ovary(1)	24				GBM - Glioblastoma multiforme(265;0.0183)		CTGGGCCAATTCCTCCTGCTC	0.483000													106	141					0	0	1	0	0
ADCK4	79934	broad.mit.edu	37	19	41220036	41220036	+	Silent	SNP	C	C	G			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr19:41220036C>G	ENST00000324464.3	-	4	526	c.225G>C	c.(223-225)ctG>ctC	p.L75L	ADCK4_ENST00000243583.6_Silent_p.L75L|ADCK4_ENST00000450541.1_Silent_p.L75L	NM_024876.3	NP_079152.3	Q96D53	ADCK4_HUMAN	aarF domain containing kinase 4	75						integral to membrane	protein serine/threonine kinase activity			NS(1)|breast(1)|endometrium(3)|large_intestine(3)|lung(6)|stomach(2)|urinary_tract(1)	17			Lung(22;9.49e-05)|LUSC - Lung squamous cell carcinoma(20;0.000219)			AGCGGTCACTCAGCTGGGAAA	0.617000													4	89					0	0	1	0	0
AC009264.1	0	broad.mit.edu	37	7	136849062	136849062	+	RNA	SNP	C	C	T			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr7:136849062C>T	ENST00000439694.1	-	0	164				AC009264.1_ENST00000592183.1_RNA|AC009264.1_ENST00000425981.2_RNA																							TAACGGATGACGTACGGGTTC	0.597000													18	58					0	0	1	0	0
CD3E	916	broad.mit.edu	37	11	118178014	118178014	+	Missense_Mutation	SNP	G	G	A			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr11:118178014G>A	ENST00000361763.4	+	3	352	c.61G>A	c.(61-63)Ggg>Agg	p.G21R	CD3E_ENST00000528600.1_Missense_Mutation_p.G21R	NM_000733.3	NP_000724.1	P07766	CD3E_HUMAN	CD3e molecule, epsilon (CD3-TCR complex)	21					G-protein coupled receptor protein signaling pathway|signal complex assembly|T cell costimulation|T cell receptor signaling pathway|transmembrane receptor protein tyrosine kinase signaling pathway	external side of plasma membrane|integral to plasma membrane	protein heterodimerization activity|protein kinase binding|receptor signaling complex scaffold activity|receptor signaling protein activity|SH3 domain binding|T cell receptor binding|transmembrane receptor activity			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(1)|ovary(2)|stomach(1)	8	all_hematologic(175;0.046)	Medulloblastoma(222;0.0425)|Breast(348;0.181)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;3.09e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0251)	Muromonab(DB00075)	TGGCGTTTGGGGGCAAGATGG	0.378000													13	9					0	0	1	0	0
MFSD8	256471	broad.mit.edu	37	4	128878655	128878655	+	Splice_Site	SNP	C	C	A			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr4:128878655C>A	ENST00000296468.3	-	3	282		c.e3+1		MFSD8_ENST00000513559.1_Splice_Site|MFSD8_ENST00000541133.1_Splice_Site|MFSD8_ENST00000515130.1_Splice_Site	NM_152778.2	NP_689991.1	Q8NHS3	MFSD8_HUMAN	major facilitator superfamily domain containing 8						cell death|transmembrane transport	integral to membrane|lysosomal membrane				cervix(2)|endometrium(1)|large_intestine(4)|liver(1)|lung(11)|ovary(1)|prostate(2)|skin(1)	23						CTAATACTTACCTACACTGCT	0.299000													13	33					5.50884e-06	5.9637e-06	1	1	0
TMPRSS4	56649	broad.mit.edu	37	11	117969704	117969704	+	Silent	SNP	C	C	G			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr11:117969704C>G	ENST00000534111.1	+	3	307	c.42C>G	c.(40-42)gtC>gtG	p.V14V	TMPRSS4_ENST00000522824.1_Silent_p.V16V|TMPRSS4_ENST00000522307.1_5'UTR|TMPRSS4_ENST00000437212.3_Silent_p.V16V|TMPRSS4_ENST00000523251.1_Intron	NM_001083947.1|NM_001173551.1|NM_019894.3	NP_001077416.1|NP_001167022.1|NP_063947.1	Q9NRS4	TMPS4_HUMAN	transmembrane protease, serine 4	16					proteolysis	integral to membrane	scavenger receptor activity|serine-type endopeptidase activity			breast(2)|central_nervous_system(2)|large_intestine(3)|lung(8)|ovary(1)|prostate(2)|skin(1)	19	all_hematologic(175;0.0487)	Medulloblastoma(222;0.0431)|all_hematologic(192;0.164)|Breast(348;0.183)|all_neural(223;0.238)		BRCA - Breast invasive adenocarcinoma(274;4.16e-05)|Epithelial(105;0.00204)		TTGCAGATGTCAAACCCCTGC	0.557000													17	48					0	0	1	0	0
DOPEY1	23033	broad.mit.edu	37	6	83846928	83846928	+	Missense_Mutation	SNP	G	G	T			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr6:83846928G>T	ENST00000349129.2	+	21	3427	c.3167G>T	c.(3166-3168)gGt>gTt	p.G1056V	DOPEY1_ENST00000237163.5_Missense_Mutation_p.G1037V|DOPEY1_ENST00000369739.3_Missense_Mutation_p.G1047V	NM_015018.3	NP_055833.2	Q5JWR5	DOP1_HUMAN	dopey family member 1	1056					protein transport					breast(4)|central_nervous_system(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(16)|ovary(5)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	67		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		AAAGGAAATGGTGAAAAGCCA	0.338000													9	47					0.00621372	0.00637581	1	1	0
SORCS3	22986	broad.mit.edu	37	10	107007067	107007067	+	Missense_Mutation	SNP	T	T	A			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr10:107007067T>A	ENST00000369701.3	+	22	3310	c.3083T>A	c.(3082-3084)gTc>gAc	p.V1028D	SORCS3_ENST00000369699.4_3'UTR	NM_014978.1	NP_055793.1	Q9UPU3	SORC3_HUMAN	sortilin-related VPS10 domain containing receptor 3	1028						integral to membrane	neuropeptide receptor activity			autonomic_ganglia(1)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(19)|lung(63)|ovary(6)|pancreas(1)|prostate(6)|skin(8)|stomach(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	131		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		ATTGGCAATGTCATCAAGCGA	0.393000													9	34					0	0	1	0	0
FBXW7	0	broad.mit.edu	37	4	153247366	153247366	+	Missense_Mutation	SNP	C	C	T			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr4:153247366C>T	ENST00000281708.4	-	10	2665	c.1436G>A	c.(1435-1437)cGa>cAa	p.R479Q	FBXW7_ENST00000603548.1_Missense_Mutation_p.R479Q|FBXW7_ENST00000393956.3_Missense_Mutation_p.R303Q|FBXW7_ENST00000263981.5_Missense_Mutation_p.R399Q|FBXW7_ENST00000603841.1_Missense_Mutation_p.R479Q|FBXW7_ENST00000296555.5_Missense_Mutation_p.R361Q	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	479					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.R479Q(29)|p.R479L(5)|p.R399Q(3)|p.R479P(2)|p.R240L(1)|p.R361P(1)|p.R399P(1)|p.?(1)|p.R361Q(1)|p.R399L(1)|p.R240Q(1)|p.R240P(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				AGTGGCATCTCGAGAACCGCT	0.403000			"""Mis, N, D, F"""		"""colorectal, endometrial, T-ALL"""								53	46					0	0	1	0	0
ROBO1	6091	broad.mit.edu	37	3	78683127	78683127	+	Missense_Mutation	SNP	C	C	T			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr3:78683127C>T	ENST00000436010.2	-	22	4319	c.3322G>A	c.(3322-3324)Gga>Aga	p.G1108R	ROBO1_ENST00000464233.1_Missense_Mutation_p.G1147R|ROBO1_ENST00000495273.1_Missense_Mutation_p.G1102R|ROBO1_ENST00000467549.1_Missense_Mutation_p.G1047R			Q9Y6N7	ROBO1_HUMAN	roundabout, axon guidance receptor, homolog 1 (Drosophila)	1147					activation of caspase activity|axon midline choice point recognition|cell migration involved in sprouting angiogenesis|chemorepulsion involved in postnatal olfactory bulb interneuron migration|homophilic cell adhesion|negative regulation of chemokine-mediated signaling pathway|negative regulation of mammary gland epithelial cell proliferation|negative regulation of negative chemotaxis|positive regulation of axonogenesis|Roundabout signaling pathway	cell surface|cytoplasm|integral to plasma membrane	axon guidance receptor activity|identical protein binding|LRR domain binding			breast(1)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(2)|lung(25)|urinary_tract(1)	44		Lung SC(41;0.0257)|Lung NSC(201;0.0439)		LUSC - Lung squamous cell carcinoma(21;0.008)|Epithelial(33;0.00999)|Lung(72;0.0177)|BRCA - Breast invasive adenocarcinoma(55;0.0274)		TAGGATCCTCCTGTGTTCTGG	0.393000													14	32					0	0	1	0	0
HSD17B7P2	0	broad.mit.edu	37	10	38654432	38654432	+	RNA	SNP	A	A	G	rs2257765		TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr10:38654432A>G	ENST00000494540.1	+	0	599					NR_003086.1																						TCATCTCGCAATGCAAGGAAA	0.453000													3	18					0	0	1	0	0
NOTCH4	4855	broad.mit.edu	37	6	32169084	32169084	+	Missense_Mutation	SNP	G	G	A			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr6:32169084G>A	ENST00000375023.3	-	22	4087	c.3949C>T	c.(3949-3951)Cgg>Tgg	p.R1317W		NM_004557.3	NP_004548.3	Q99466	NOTC4_HUMAN	notch 4	1317					cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			NS(1)|autonomic_ganglia(1)|breast(4)|central_nervous_system(4)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|lung(47)|ovary(5)|prostate(4)|skin(10)|upper_aerodigestive_tract(1)|urinary_tract(1)	100						GACAGCACCCGGGCCAGGGCA	0.642000													17	85					0	0	1	0	0
MUC16	94025	broad.mit.edu	37	19	9073782	9073782	+	Missense_Mutation	SNP	A	A	G			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr19:9073782A>G	ENST00000397910.4	-	3	13867	c.13664T>C	c.(13663-13665)cTc>cCc	p.L4555P		NM_024690.2	NP_078966.2	Q8WXI7	MUC16_HUMAN	mucin 16, cell surface associated	4557	Thr-rich.				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			NS(9)|autonomic_ganglia(1)|breast(26)|central_nervous_system(11)|cervix(1)|endometrium(46)|haematopoietic_and_lymphoid_tissue(5)|kidney(35)|large_intestine(91)|liver(1)|lung(278)|ovary(17)|pancreas(2)|prostate(17)|skin(18)|soft_tissue(1)|stomach(8)|upper_aerodigestive_tract(16)|urinary_tract(7)	590						GCTGACTGGGAGAGTGGAATG	0.493000													13	18					0	0	1	0	0
CREBBP	1387	broad.mit.edu	37	16	3778746	3778746	+	Missense_Mutation	SNP	A	A	G			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr16:3778746A>G	ENST00000262367.5	-	31	7111	c.6302T>C	c.(6301-6303)aTc>aCc	p.I2101T	CREBBP_ENST00000382070.3_Missense_Mutation_p.I2063T	NM_004380.2	NP_004371.2	Q92793	CBP_HUMAN	CREB binding protein	2101					cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|central_nervous_system(4)|cervix(3)|endometrium(12)|haematopoietic_and_lymphoid_tissue(125)|kidney(5)|large_intestine(32)|lung(43)|ovary(18)|pancreas(2)|prostate(6)|skin(9)|soft_tissue(1)|stomach(3)|upper_aerodigestive_tract(5)|urinary_tract(21)	295		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		GCGCTGTTTGATGAAAGCTGC	0.612000			"""T, N, F, Mis, O"""	"""MLL, MORF, RUNXBP2"""	"""ALL, AML, DLBCL, B-NHL """		Rubinstein-Taybi syndrome						195	20					0	0	1	0	0
ADAMTS3	9508	broad.mit.edu	37	4	73188778	73188778	+	Missense_Mutation	SNP	G	G	A			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr4:73188778G>A	ENST00000286657.4	-	6	934	c.898C>T	c.(898-900)Cat>Tat	p.H300Y	RP11-373J21.1_ENST00000503918.1_RNA	NM_014243.2	NP_055058.2	O15072	ATS3_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 3	300	Peptidase M12B.				collagen catabolic process|collagen fibril organization|proteolysis	proteinaceous extracellular matrix	heparin binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(5)|kidney(6)|large_intestine(21)|lung(33)|ovary(1)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	76			Epithelial(6;4.97e-05)|OV - Ovarian serous cystadenocarcinoma(6;5.66e-05)|all cancers(17;0.000486)|Lung(101;0.103)|LUSC - Lung squamous cell carcinoma(112;0.154)			ACATTTATATGCACTCCGAGG	0.363000													36	122					0	0	1	0	0
DCT	1638	broad.mit.edu	37	13	95114274	95114274	+	Missense_Mutation	SNP	A	A	T			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr13:95114274A>T	ENST00000377028.5	-	5	1446	c.1033T>A	c.(1033-1035)Ttc>Atc	p.F345I	DCT_ENST00000446125.1_Missense_Mutation_p.F345I	NM_001922.3	NP_001913.2	P40126	TYRP2_HUMAN	dopachrome tautomerase	345					epidermis development|melanin biosynthetic process from tyrosine	cytosol|integral to membrane|melanosome membrane|microsome	copper ion binding|dopachrome isomerase activity|oxidoreductase activity			NS(1)|breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|liver(1)|lung(16)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)	50	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;3.71e-42)|all_epithelial(2;3.76e-31)|all_lung(2;5.16e-14)|Lung NSC(4;1.33e-13)|Breast(118;0.0013)|Hepatocellular(115;0.00886)|Renal(2;0.00988)		COAD - Colon adenocarcinoma(199;7.07e-05)|GBM - Glioblastoma multiforme(99;0.000472)		CTGAAACTGAAGGTAGAGTTC	0.458000													11	25					0	0	1	0	0
DEPDC5	9681	broad.mit.edu	37	22	32232998	32232998	+	Silent	SNP	T	T	C			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr22:32232998T>C	ENST00000400246.1	+	26	2353	c.2211T>C	c.(2209-2211)tgT>tgC	p.C737C	DEPDC5_ENST00000382105.2_Silent_p.C659C|DEPDC5_ENST00000382112.3_Silent_p.C728C|DEPDC5_ENST00000382111.2_Silent_p.C737C|DEPDC5_ENST00000400249.2_Silent_p.C728C|DEPDC5_ENST00000400248.1_Silent_p.C728C|DEPDC5_ENST00000266091.3_Silent_p.C737C|DEPDC5_ENST00000535622.1_Silent_p.C659C			O75140	DEPD5_HUMAN	DEP domain containing 5	728					intracellular signal transduction					breast(1)|central_nervous_system(5)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(24)|ovary(5)|pancreas(2)|prostate(3)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	63						CAGGCTTCTGTTGCACAGTTG	0.577000													30	36					0	0	1	0	0
CPOX	1371	broad.mit.edu	37	3	98304286	98304286	+	Splice_Site	SNP	G	G	C			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr3:98304286G>C	ENST00000264193.2	-	5	1389	c.1172_splice	c.e5+1	p.R391_splice		NM_000097.5	NP_000088.3	P36551	HEM6_HUMAN	coproporphyrinogen oxidase	391						mitochondrial intermembrane space	coproporphyrinogen oxidase activity|protein homodimerization activity			endometrium(1)|large_intestine(3)|lung(8)|ovary(1)|prostate(1)|skin(1)|stomach(1)	16						GTCACTTACCGTCCTCTTCTG	0.478000													47	144					0	0	1	0	0
SLC35G3	146861	broad.mit.edu	37	17	33521054	33521054	+	Silent	SNP	G	G	A			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr17:33521054G>A	ENST00000297307.5	-	1	358	c.273C>T	c.(271-273)ggC>ggT	p.G91G		NM_152462.2	NP_689675.1	Q8N808	AMAC1_HUMAN	solute carrier family 35, member G3	91	DUF6 1.					integral to membrane											GAAGGGGGTCGCCACGCAGTT	0.587000													123	13					0	0	1	0	0
LRRCC1	85444	broad.mit.edu	37	8	86038971	86038971	+	Silent	SNP	T	T	G			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr8:86038971T>G	ENST00000414626.2	+	8	2149	c.1260T>G	c.(1258-1260)gcT>gcG	p.A420A	LRRCC1_ENST00000360375.3_Silent_p.A440A			Q9C099	LRCC1_HUMAN	leucine rich repeat and coiled-coil centrosomal protein 1	440					cell division|mitosis	centriole|nucleus				breast(3)|central_nervous_system(1)|endometrium(4)|kidney(9)|large_intestine(7)|lung(16)|skin(1)|upper_aerodigestive_tract(2)	43						GATGGAGAGCTGAGCAAGCCG	0.373000													13	24					0	0	1	0	0
CCDC39	339829	broad.mit.edu	37	3	180337633	180337633	+	Missense_Mutation	SNP	A	A	T			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr3:180337633A>T	ENST00000442201.2	-	15	2243	c.2124T>A	c.(2122-2124)aaT>aaA	p.N708K	CCDC39_ENST00000273654.4_Intron	NM_181426.1	NP_852091.1	Q9UFE4	CCD39_HUMAN	coiled-coil domain containing 39	708					axonemal dynein complex assembly|ciliary cell motility|cilium movement involved in determination of left/right asymmetry|flagellar cell motility	cilium axoneme|cytoplasm|cytoskeleton				NS(1)|breast(1)|endometrium(4)|large_intestine(9)|lung(22)|ovary(6)|prostate(2)	45	all_cancers(143;9.31e-15)|Ovarian(172;0.0212)		OV - Ovarian serous cystadenocarcinoma(80;5.62e-23)|GBM - Glioblastoma multiforme(14;0.000558)			ATTGCTTATAATTGTTGTTAC	0.338000													4	16					0	0	1	0	0
STAG1	10274	broad.mit.edu	37	3	136342011	136342011	+	Missense_Mutation	SNP	T	T	C			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr3:136342011T>C	ENST00000383202.2	-	3	365	c.109A>G	c.(109-111)Agg>Ggg	p.R37G	STAG1_ENST00000236698.5_Missense_Mutation_p.R37G|STAG1_ENST00000434713.2_5'UTR|STAG1_ENST00000480733.1_Missense_Mutation_p.R37G	NM_005862.2	NP_005853.2	Q8WVM7	STAG1_HUMAN	stromal antigen 1	37					cell division|chromosome segregation|mitotic metaphase/anaphase transition|mitotic prometaphase	cell junction|chromatin|chromosome, centromeric region|nucleoplasm	protein binding			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(16)|lung(16)|ovary(2)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	58						GGACGACCCCTTTTTCTTTTT	0.388000													4	207					0	0	1	0	0
ZNF33B	7582	broad.mit.edu	37	10	43088129	43088129	+	Missense_Mutation	SNP	T	T	G			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr10:43088129T>G	ENST00000359467.3	-	5	2383	c.2269A>C	c.(2269-2271)Acc>Ccc	p.T757P	ZNF33B_ENST00000486187.1_RNA	NM_006955.1	NP_008886.1	Q06732	ZN33B_HUMAN	zinc finger protein 33B	757						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(15)|skin(1)|stomach(1)	29						TGAGAGAAGGTTTTCCTGCAT	0.358000													27	116					0	0	1	0	0
ATP4A	495	broad.mit.edu	37	19	36044045	36044045	+	Missense_Mutation	SNP	G	G	A			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr19:36044045G>A	ENST00000262623.3	-	18	2673	c.2645C>T	c.(2644-2646)aCg>aTg	p.T882M		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	882					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	GGCCATTGCCGTGAAGTAGTC	0.602000													4	132					0	0	1	0	0
PTPRM	5797	broad.mit.edu	37	18	8380347	8380347	+	Silent	SNP	A	A	C			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr18:8380347A>C	ENST00000332175.8	+	27	4838	c.3801A>C	c.(3799-3801)acA>acC	p.T1267T	PTPRM_ENST00000444013.1_Silent_p.T1054T|PTPRM_ENST00000400053.4_Silent_p.T1205T|PTPRM_ENST00000400060.4_Silent_p.T1281T|PTPRM_ENST00000580170.1_Silent_p.T1280T	NM_002845.3	NP_002836.3	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	1267	Tyrosine-protein phosphatase 2.				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			breast(3)|central_nervous_system(1)|cervix(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(32)|lung(25)|ovary(2)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)	90		Colorectal(10;0.234)				TGCCAAACACAGTGAAAGACT	0.443000													16	84					0	0	1	0	0
LINGO4	339398	broad.mit.edu	37	1	151774911	151774911	+	Missense_Mutation	SNP	G	G	T			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr1:151774911G>T	ENST00000368820.3	-	2	1207	c.270C>A	c.(268-270)gaC>gaA	p.D90E		NM_001004432.2	NP_001004432.1	Q6UY18	LIGO4_HUMAN	leucine rich repeat and Ig domain containing 4	90						integral to membrane				breast(2)|cervix(1)|endometrium(4)|large_intestine(5)|lung(4)|ovary(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	21	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			TGTAGCTGAGGTCCAATTCCT	0.612000													10	68					0.00621372	0.00637581	1	1	0
MCM3	4172	broad.mit.edu	37	6	52143605	52143605	+	Missense_Mutation	SNP	C	C	A			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr6:52143605C>A	ENST00000596288.1	-	6	976	c.949G>T	c.(949-951)Gct>Tct	p.A317S	MCM3_ENST00000419835.2_Missense_Mutation_p.A226S|MCM3_ENST00000476448.1_5'UTR|MCM3_ENST00000229854.7_Missense_Mutation_p.A272S	NM_002388.4	NP_002379.3	P25205	MCM3_HUMAN	minichromosome maintenance complex component 3	272	MCM.				cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	alpha DNA polymerase:primase complex|centrosome|MCM complex|perinuclear region of cytoplasm	ATP binding|DNA binding|helicase activity|protein binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	20	Lung NSC(77;0.0931)					GAGGGCTGAGCATCCTTGCTC	0.438000													10	109					0.0581538	0.0591564	1	1	0
PLCL1	5334	broad.mit.edu	37	2	198949947	198949947	+	Missense_Mutation	SNP	C	C	T			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr2:198949947C>T	ENST00000428675.1	+	2	2104	c.1706C>T	c.(1705-1707)tCg>tTg	p.S569L	PLCL1_ENST00000437704.2_Missense_Mutation_p.S471L	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	569					intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	CGAAGGATGTCGGTAGATTAC	0.398000													21	45					0	0	1	0	0
SUPT5H	6829	broad.mit.edu	37	19	39962347	39962347	+	Silent	SNP	C	C	T			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr19:39962347C>T	ENST00000599117.1	+	21	2294	c.1927C>T	c.(1927-1929)Ctg>Ttg	p.L643L	SUPT5H_ENST00000359191.6_Silent_p.L639L|SUPT5H_ENST00000402194.2_Silent_p.L639L|SUPT5H_ENST00000598725.1_Silent_p.L643L|SUPT5H_ENST00000432763.2_Silent_p.L643L			O00267	SPT5H_HUMAN	suppressor of Ty 5 homolog (S. cerevisiae)	643					cell cycle|chromatin remodeling|mRNA capping|negative regulation of transcription elongation, DNA-dependent|negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription elongation from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|positive regulation of viral transcription|response to organic substance|retroviral genome replication|transcription elongation from RNA polymerase II promoter	nucleoplasm	enzyme binding|protein heterodimerization activity			breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(13)|lung(12)|ovary(3)|pancreas(1)|prostate(5)|skin(1)|upper_aerodigestive_tract(1)	51	all_cancers(60;6.69e-07)|all_lung(34;2.66e-08)|Lung NSC(34;3e-08)|all_epithelial(25;1.57e-06)|Ovarian(47;0.159)		Epithelial(26;3.9e-26)|all cancers(26;1.35e-23)|LUSC - Lung squamous cell carcinoma(53;0.000657)			GACCCGCCACCTGGTGCTGGC	0.602000													10	47					0	0	1	0	0
RP11-571M6.15	0	broad.mit.edu	37	12	58177020	58177020	+	Nonstop_Mutation	SNP	T	T	C			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr12:58177020T>C	ENST00000471530.1	+	2	229	c.229T>C	c.(229-231)Taa>Caa	p.*77Q	TSFM_ENST00000548851.1_Missense_Mutation_p.V62A|TSFM_ENST00000543727.1_Missense_Mutation_p.V62A|TSFM_ENST00000350762.5_5'UTR|TSFM_ENST00000454289.3_Missense_Mutation_p.V62A|TSFM_ENST00000550559.1_Missense_Mutation_p.V62A|TSFM_ENST00000540550.1_Missense_Mutation_p.V62A|TSFM_ENST00000323833.8_Missense_Mutation_p.V62A|TSFM_ENST00000497617.1_3'UTR|RP11-571M6.15_ENST00000553083.1_3'UTR																							TACTCCTTTGTAAATTGCAAG	0.567000											OREG0021954	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	59	101					0	0	1	0	0
RTL1	388015	broad.mit.edu	37	14	101349485	101349485	+	Missense_Mutation	SNP	G	G	C			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr14:101349485G>C	ENST00000534062.1	-	1	1699	c.1641C>G	c.(1639-1641)caC>caG	p.H547Q		NM_001134888.2	NP_001128360.1	E9PKS8	E9PKS8_HUMAN	retrotransposon-like 1	547										breast(1)|endometrium(5)|kidney(4)|large_intestine(1)|lung(5)|pancreas(1)|prostate(2)|skin(2)	21						GGCTCATGCCGTGCCTCTCTA	0.602000													8	1					0	0	1	0	0
ZSWIM8	23053	broad.mit.edu	37	10	75554072	75554072	+	Silent	SNP	C	C	T			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr10:75554072C>T	ENST00000604729.1	+	13	3090	c.2793C>T	c.(2791-2793)gaC>gaT	p.D931D	ZSWIM8_ENST00000431225.1_3'UTR|ZSWIM8_ENST00000603114.1_Silent_p.D898D|ZSWIM8_ENST00000605216.1_Silent_p.D931D|ZSWIM8_ENST00000604524.1_Silent_p.D931D|ZSWIM8_ENST00000398706.2_Silent_p.D931D					zinc finger, SWIM-type containing 8																		TCATCTTTGACGTTCTCTGTG	0.537000													110	43					0	0	1	0	0
GAREM	64762	broad.mit.edu	37	18	29850241	29850241	+	Missense_Mutation	SNP	G	G	A	rs144218911	byFrequency	TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr18:29850241G>A	ENST00000399218.4	-	5	1727	c.1672C>T	c.(1672-1674)Cgg>Tgg	p.R558W	GAREM_ENST00000269209.6_Missense_Mutation_p.R558W	NM_001242409.1|NM_022751.2	NP_001229338.1|NP_073588.1			GRB2 associated, regulator of MAPK1																		GTCTGTTGCCGCGCTGGCTTG	0.582000													16	67					0	0	1	0	0
CDCP2	200008	broad.mit.edu	37	1	54605311	54605311	+	Missense_Mutation	SNP	C	C	T	rs138436244	byFrequency	TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr1:54605311C>T	ENST00000371330.1	-	4	2079	c.1232G>A	c.(1231-1233)gGt>gAt	p.G411D	CDCP2_ENST00000530059.1_Intron	NM_201546.2	NP_963840.2	Q5VXM1	CDCP2_HUMAN	CUB domain containing protein 2	411						extracellular region				kidney(1)|large_intestine(6)|lung(13)|ovary(1)|prostate(2)|stomach(1)	24						CTGGAGAAGACCATTCATGGG	0.597000													50	23					0	0	1	0	0
EP400	57634	broad.mit.edu	37	12	132489700	132489700	+	Missense_Mutation	SNP	C	C	T			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr12:132489700C>T	ENST00000333577.4	+	14	3123	c.3014C>T	c.(3013-3015)cCt>cTt	p.P1005L	EP400_ENST00000389562.2_Missense_Mutation_p.P968L|EP400_ENST00000330386.6_Missense_Mutation_p.P969L|EP400_ENST00000389561.2_Missense_Mutation_p.P969L|EP400_ENST00000332482.4_Missense_Mutation_p.P932L			Q96L91	EP400_HUMAN	E1A binding protein p400	1005	Interactions with RUVBL1 and RUVBL2.				histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity			NS(1)|breast(6)|central_nervous_system(10)|cervix(1)|endometrium(21)|kidney(13)|large_intestine(25)|lung(56)|ovary(5)|prostate(8)|skin(6)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(3)	161	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		CGGCCGAAGCCTGATGGGGAG	0.567000													6	7					0	0	1	0	0
IGKV2D-30	0	broad.mit.edu	37	2	89976340	89976340	+	RNA	SNP	C	C	T			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr2:89976340C>T	ENST00000474213.1	+	0	246																											ATCTCCAAGGCGCCTAATTTA	0.517000													47	6					0	0	1	0	0
RAB33A	9363	broad.mit.edu	37	X	129306073	129306073	+	Missense_Mutation	SNP	C	C	A			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chrX:129306073C>A	ENST00000257017.4	+	1	451	c.37C>A	c.(37-39)Ccc>Acc	p.P13T		NM_004794.2	NP_004785.1	Q14088	RB33A_HUMAN	RAB33A, member RAS oncogene family	13					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding|GTPase activity|protein binding			breast(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(5)	11						GAGCCTGCAGCCCGCCTCGGC	0.647000													19	18					5.35267e-07	5.84828e-07	1	1	0
TRMT13	54482	broad.mit.edu	37	1	100613620	100613620	+	Missense_Mutation	SNP	A	A	G			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr1:100613620A>G	ENST00000370141.2	+	10	994	c.988A>G	c.(988-990)Att>Gtt	p.I330V		NM_019083.2	NP_061956.2			tRNA methyltransferase 13 homolog (S. cerevisiae)																		TGTGGCTGGCATTGTTATTGC	0.413000													18	39					0	0	1	0	0
MUC4	4585	broad.mit.edu	37	3	195508194	195508194	+	Silent	SNP	T	T	G			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr3:195508194T>G	ENST00000463781.3	-	2	10716	c.10257A>C	c.(10255-10257)acA>acC	p.T3419T	MUC4_ENST00000475231.1_Silent_p.T3419T|MUC4_ENST00000349607.4_Intron|MUC4_ENST00000346145.4_Intron	NM_018406.6	NP_060876.5	Q99102	MUC4_HUMAN	mucin 4, cell surface associated	187					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		TGGCGTGACCTGTGGATGCTG	0.587000													4	11					0	0	1	0	0
KIF26B	55083	broad.mit.edu	37	1	245775144	245775144	+	Missense_Mutation	SNP	T	T	G			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr1:245775144T>G	ENST00000366518.4	+	6	925	c.821T>G	c.(820-822)tTt>tGt	p.F274C	KIF26B_ENST00000407071.2_Missense_Mutation_p.F655C			Q2KJY2	KI26B_HUMAN	kinesin family member 26B	655					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			breast(1)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(4)|lung(21)|ovary(4)|prostate(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			AAGGCTGCCTTTTTCCTGGAT	0.602000													19	52					0	0	1	0	0
IMPG1	3617	broad.mit.edu	37	6	76715225	76715225	+	Missense_Mutation	SNP	G	G	A			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr6:76715225G>A	ENST00000369950.3	-	10	1103	c.914C>T	c.(913-915)aCg>aTg	p.T305M	IMPG1_ENST00000369963.3_3'UTR	NM_001563.2	NP_001554.2	Q17R60	IMPG1_HUMAN	interphotoreceptor matrix proteoglycan 1	305	SEA 1.				visual perception	proteinaceous extracellular matrix	extracellular matrix structural constituent|receptor activity			breast(5)|cervix(1)|endometrium(7)|kidney(2)|large_intestine(8)|lung(27)|ovary(2)|pancreas(1)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	63		Acute lymphoblastic leukemia(125;0.0418)|all_hematologic(105;0.222)				AAAGATGGCCGTAAGTTGCAT	0.448000													17	94					0	0	1	0	0
OR1N2	138882	broad.mit.edu	37	9	125315642	125315642	+	Missense_Mutation	SNP	C	C	A			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr9:125315642C>A	ENST00000373688.2	+	1	252	c.194C>A	c.(193-195)gCc>gAc	p.A65D		NM_001004457.1	NP_001004457.1	Q8NGR9	OR1N2_HUMAN	olfactory receptor, family 1, subfamily N, member 2	65					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|large_intestine(6)|lung(10)|ovary(2)|skin(3)|stomach(3)	26						ATTATCCTGGCCATCAGCTCT	0.522000													45	44					2.43468e-25	2.81659e-25	1	1	0
BCL11A	53335	broad.mit.edu	37	2	60773229	60773229	+	Missense_Mutation	SNP	A	A	G			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr2:60773229A>G	ENST00000335712.6	-	2	489	c.262T>C	c.(262-264)Tca>Cca	p.S88P	BCL11A_ENST00000537768.1_5'UTR|BCL11A_ENST00000358510.4_Missense_Mutation_p.S88P|BCL11A_ENST00000356842.4_Missense_Mutation_p.S88P|BCL11A_ENST00000538214.1_Missense_Mutation_p.S88P|BCL11A_ENST00000359629.5_Missense_Mutation_p.S88P	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	88	Required for nuclear body formation and for SUMO1 recruitment (By similarity).				negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			TCGATTGGTGAAGGGGAAGGT	0.463000			T	IGH@	B-CLL								20	46					0	0	1	0	0
SLC14A2	8170	broad.mit.edu	37	18	43248429	43248429	+	Missense_Mutation	SNP	A	A	T			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr18:43248429A>T	ENST00000255226.6	+	15	2839	c.2023A>T	c.(2023-2025)Atg>Ttg	p.M675L	SLC14A2_ENST00000589658.1_Missense_Mutation_p.M152L|SLC14A2_ENST00000586448.1_Missense_Mutation_p.M675L	NM_007163.3	NP_009094.3	Q15849	UT2_HUMAN	solute carrier family 14 (urea transporter), member 2	675						apical plasma membrane|integral to membrane|membrane fraction	protein binding|urea transmembrane transporter activity			NS(1)|central_nervous_system(1)|endometrium(5)|kidney(4)|large_intestine(8)|lung(35)|ovary(1)|prostate(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	63						CGTCATCATCATGTCCATGTC	0.498000													16	88					0	0	1	0	0
RAD54B	25788	broad.mit.edu	37	8	95403998	95403998	+	Nonsense_Mutation	SNP	G	G	A			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr8:95403998G>A	ENST00000336148.5	-	10	1772	c.1648C>T	c.(1648-1650)Cga>Tga	p.R550*		NM_012415.3	NP_036547.1	O95073	FSBP_HUMAN	RAD54 homolog B (S. cerevisiae)	0					double-strand break repair via homologous recombination|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA translocase activity|protein binding			breast(1)|central_nervous_system(1)|endometrium(3)|kidney(4)|large_intestine(10)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	39	Breast(36;4.5e-05)		BRCA - Breast invasive adenocarcinoma(8;0.00217)			GCTCCTGGTCGGCAAAAGACA	0.393000								Direct reversal of damage;Homologous recombination					40	96					0	0	1	0	0
GAST	2520	broad.mit.edu	37	17	39872040	39872040	+	Missense_Mutation	SNP	G	G	C			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr17:39872040G>C	ENST00000329402.3	+	3	289	c.222G>C	c.(220-222)aaG>aaC	p.K74N	JUP_ENST00000540235.1_Intron	NM_000805.4	NP_000796.1	P01350	GAST_HUMAN	gastrin	74						extracellular region	hormone activity			endometrium(1)|kidney(1)|large_intestine(2)|lung(3)	7		Breast(137;0.000307)	BRCA - Breast invasive adenocarcinoma(4;0.0677)			ACCCGTCCAAGAAGCAGGGAC	0.557000													23	114					0	0	1	0	0
KANSL2	54934	broad.mit.edu	37	12	49054403	49054403	+	Splice_Site	SNP	C	C	A			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr12:49054403C>A	ENST00000550347.1	-	7	1566		c.e7-1		KANSL2_ENST00000548701.1_Splice_Site|KANSL2_ENST00000420613.2_Splice_Site|KANSL2_ENST00000553086.1_Splice_Site			Q9H9L4	CL041_HUMAN	KAT8 regulatory NSL complex subunit 2																		TGACAAATATCTGTAGAAAAA	0.403000													3	11					0.150653	0.151941	1	1	0
KIR3DX1	0	broad.mit.edu	37	19	55045110	55045110	+	Missense_Mutation	SNP	A	A	G			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr19:55045110A>G	ENST00000335056.3	+	3	268	c.230A>G	c.(229-231)aAc>aGc	p.N77S																	endometrium(1)|kidney(2)|large_intestine(4)|lung(14)|ovary(1)|pancreas(1)|skin(1)	24				GBM - Glioblastoma multiforme(193;0.099)		GGCCTTTCCAACAACATCACC	0.507000													10	48					0	0	1	0	0
OR51Q1	390061	broad.mit.edu	37	11	5443752	5443752	+	Nonsense_Mutation	SNP	G	G	T			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr11:5443752G>T	ENST00000300778.4	+	1	412	c.322G>T	c.(322-324)Gga>Tga	p.G108*	HBE1_ENST00000380237.1_Intron|HBG2_ENST00000380252.1_Intron|HBG2_ENST00000380259.2_Intron|AC104389.28_ENST00000415970.1_RNA	NM_001004757.2	NP_001004757.1	Q8NH59	O51Q1_HUMAN	olfactory receptor, family 51, subfamily Q, member 1 (gene/pseudogene)	108					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(2)|large_intestine(3)|liver(2)|lung(21)|ovary(1)|prostate(1)|skin(1)|stomach(1)|urinary_tract(2)	37		Medulloblastoma(188;0.0075)|all_neural(188;0.0572)|Breast(177;0.0675)		Epithelial(150;2.18e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CTTCCTTCATGGATTCTCCTT	0.502000													57	38					2.14674e-31	2.50807e-31	1	1	0
SYNGAP1	8831	broad.mit.edu	37	6	33391325	33391325	+	Missense_Mutation	SNP	C	C	T			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr6:33391325C>T	ENST00000418600.2	+	2	240	c.139C>T	c.(139-141)Cgg>Tgg	p.R47W	SYNGAP1_ENST00000496374.1_3'UTR|SYNGAP1_ENST00000293748.5_Missense_Mutation_p.R47W	NM_006772.2	NP_006763.2	Q96PV0	SYGP1_HUMAN	synaptic Ras GTPase activating protein 1	47					negative regulation of Ras protein signal transduction|signal transduction	cytoplasm|intrinsic to internal side of plasma membrane	Ras GTPase activator activity|SH3 domain binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(9)|lung(15)|ovary(7)|pancreas(1)|stomach(1)|urinary_tract(1)	43						TTGGAACCCTCGGTTCTGCAT	0.542000													43	172					0	0	1	0	0
KLHDC2	23588	broad.mit.edu	37	14	50249133	50249133	+	Silent	SNP	T	T	G			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr14:50249133T>G	ENST00000298307.5	+	11	1863	c.1002T>G	c.(1000-1002)gtT>gtG	p.V334V	KLHDC2_ENST00000554589.1_Silent_p.V334V|KLHDC2_ENST00000557247.1_3'UTR	NM_014315.2	NP_055130.1	Q9Y2U9	KLDC2_HUMAN	kelch domain containing 2	334						nucleus	protein binding			endometrium(3)|large_intestine(3)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	16	all_epithelial(31;0.000959)|Breast(41;0.0117)					AAGTAATTGTTTTTGGTGGAT	0.403000													16	42					0	0	1	0	0
RPSAP52	0	broad.mit.edu	37	12	66152702	66152702	+	RNA	SNP	C	C	T			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr12:66152702C>T	ENST00000489520.2	-	0	241					NR_026825.2																						TTTGGTGCCACCTAATTGGAT	0.433000													3	8					0	0	1	0	0
RAD54L	8438	broad.mit.edu	37	1	46714224	46714224	+	Missense_Mutation	SNP	C	C	A			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr1:46714224C>A	ENST00000371975.4	+	2	718	c.44C>A	c.(43-45)cCt>cAt	p.P15H	RAD54L_ENST00000442598.1_Missense_Mutation_p.P15H	NM_003579.3	NP_003570.2	Q92698	RAD54_HUMAN	RAD54-like (S. cerevisiae)	15					meiosis	nucleus	ATP binding|DNA binding|helicase activity	p.P15H(1)		breast(2)|cervix(1)|kidney(3)|large_intestine(5)|liver(1)|lung(6)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	25	Acute lymphoblastic leukemia(166;0.155)	Breast(1374;0.0634)		KIRC - Kidney renal clear cell carcinoma(1967;0.000896)		AAGAGAAAACCTGAAGGCAGG	0.547000								Direct reversal of damage;Homologous recombination					18	35					5.35267e-07	5.84828e-07	1	1	0
RPS6KA6	27330	broad.mit.edu	37	X	83403058	83403058	+	Missense_Mutation	SNP	G	G	A			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chrX:83403058G>A	ENST00000262752.2	-	4	339	c.332C>T	c.(331-333)tCt>tTt	p.S111F	RPS6KA6_ENST00000543399.1_Missense_Mutation_p.S111F	NM_014496.4	NP_055311.1	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 6	111	Protein kinase 1.				axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity	p.S111F(1)		NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(26)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	46						ACCTTTTAAAGAGGCTTTTTT	0.299000													9	14					0	0	1	0	0
CELF6	60677	broad.mit.edu	37	15	72608246	72608246	+	Silent	SNP	G	G	A			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr15:72608246G>A	ENST00000287202.5	-	2	539	c.285C>T	c.(283-285)tgC>tgT	p.C95C	RP11-106M3.2_ENST00000379915.4_RNA|CELF6_ENST00000539635.1_5'UTR|RP11-106M3.3_ENST00000570175.1_RNA|CELF6_ENST00000567083.1_Silent_p.C95C	NM_052840.4	NP_443072.3	Q96J87	CELF6_HUMAN	CUGBP, Elav-like family member 6	95	RRM 1.				mRNA processing|regulation of alternative nuclear mRNA splicing, via spliceosome	cytoplasm|nucleus	nucleotide binding|RNA binding			breast(1)|central_nervous_system(2)|kidney(2)|large_intestine(2)|lung(2)|ovary(1)|prostate(1)|skin(2)	13						AGTCCCGGGCGCAGTAGGTGA	0.587000													3	18					0	0	1	0	0
SYNE1	23345	broad.mit.edu	37	6	152823805	152823805	+	Missense_Mutation	SNP	T	T	A			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr6:152823805T>A	ENST00000367255.5	-	10	1452	c.851A>T	c.(850-852)gAc>gTc	p.D284V	SYNE1_ENST00000367248.3_Missense_Mutation_p.D291V|SYNE1_ENST00000466159.2_Missense_Mutation_p.D284V|SYNE1_ENST00000423061.1_Missense_Mutation_p.D291V|SYNE1_ENST00000265368.4_Missense_Mutation_p.D284V|SYNE1_ENST00000448038.1_Missense_Mutation_p.D291V|SYNE1_ENST00000341594.5_Missense_Mutation_p.D284V|SYNE1_ENST00000367253.4_Missense_Mutation_p.D284V|SYNE1_ENST00000413186.2_Missense_Mutation_p.D284V	NM_182961.3	NP_892006.3	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	284	Actin-binding.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			NS(3)|biliary_tract(1)|breast(17)|central_nervous_system(21)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(4)|kidney(16)|large_intestine(138)|liver(1)|lung(190)|ovary(11)|pancreas(5)|prostate(12)|skin(20)|stomach(3)|upper_aerodigestive_tract(33)|urinary_tract(19)	524		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		ATTGTGGATGTCAGGATAATG	0.373000										HNSCC(10;0.0054)			9	44					0	0	1	0	0
HCFC2	29915	broad.mit.edu	37	12	104492131	104492131	+	Missense_Mutation	SNP	C	C	T			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr12:104492131C>T	ENST00000229330.4	+	13	1855	c.1751C>T	c.(1750-1752)cCt>cTt	p.P584L	HCFC2_ENST00000550335.1_3'UTR	NM_013320.2	NP_037452.1	Q9Y5Z7	HCFC2_HUMAN	host cell factor C2	584	Fibronectin type-III 2.				regulation of transcription from RNA polymerase II promoter|viral reproduction	cytoplasm|nucleus	transcription coactivator activity			breast(3)|central_nervous_system(1)|endometrium(4)|large_intestine(6)|lung(14)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	35						AAAGAGACTCCTTCAAATCCA	0.343000													8	27					0	0	1	0	0
CDH22	64405	broad.mit.edu	37	20	44856148	44856148	+	Splice_Site	SNP	G	G	T			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr20:44856148G>T	ENST00000372262.3	-	3	1069	c.670_splice	c.e3+1	p.T223_splice	CDH22_ENST00000537909.1_Splice_Site_p.T223_splice	NM_021248.1	NP_067071.1	Q9UJ99	CAD22_HUMAN	cadherin 22, type 2	223	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			endometrium(3)|kidney(1)|large_intestine(9)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(4)|urinary_tract(3)	44		Myeloproliferative disorder(115;0.0122)				gccccTCACCGGTCTTGGGGT	0.716000													6	20					0.00198382	0.0020716	1	1	0
KCNK5	8645	broad.mit.edu	37	6	39162482	39162482	+	Missense_Mutation	SNP	T	T	C			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr6:39162482T>C	ENST00000359534.3	-	3	691	c.353A>G	c.(352-354)tAt>tGt	p.Y118C		NM_003740.3	NP_003731.1	O95279	KCNK5_HUMAN	potassium channel, subfamily K, member 5	118					excretion	integral to plasma membrane	potassium channel activity|voltage-gated ion channel activity			central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(6)|lung(4)|skin(3)	19						GAAGAGACCATAGAAAACACA	0.582000													39	177					0	0	1	0	0
RP11-262H14.1	0	broad.mit.edu	37	9	66466226	66466226	+	RNA	SNP	A	A	G			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr9:66466226A>G	ENST00000424345.1	+	0	859																											cctagcggagagagagccgga	0.453000													4	5					0	0	1	0	0
PXDN	7837	broad.mit.edu	37	2	1652752	1652752	+	Missense_Mutation	SNP	C	C	T			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr2:1652752C>T	ENST00000252804.4	-	17	2850	c.2800G>A	c.(2800-2802)Ggc>Agc	p.G934S		NM_012293.1	NP_036425.1	Q92626	PXDN_HUMAN	peroxidasin homolog (Drosophila)	934					extracellular matrix organization|hydrogen peroxide catabolic process|immune response	endoplasmic reticulum|extracellular space|proteinaceous extracellular matrix	extracellular matrix structural constituent|heme binding|interleukin-1 receptor antagonist activity|peroxidase activity			breast(1)|cervix(3)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(24)|lung(48)|ovary(3)|pancreas(8)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	112	Acute lymphoblastic leukemia(172;0.0627)|all_hematologic(175;0.0797)	all_cancers(51;0.0845)|Lung NSC(108;0.00641)|all_epithelial(98;0.00716)		all cancers(51;0.0492)|OV - Ovarian serous cystadenocarcinoma(76;0.0973)|Epithelial(75;0.17)|GBM - Glioblastoma multiforme(21;0.228)		CGCAGCAGGCCGCGGTGGCTG	0.692000													18	28					0	0	1	0	0
FAM92B	339145	broad.mit.edu	37	16	85135890	85135890	+	Missense_Mutation	SNP	G	G	A			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr16:85135890G>A	ENST00000539556.1	-	7	736	c.581C>T	c.(580-582)gCc>gTc	p.A194V		NM_198491.1	NP_940893.1	Q6ZTR7	FA92B_HUMAN	family with sequence similarity 92, member B	194										breast(1)|central_nervous_system(1)|kidney(1)|large_intestine(5)|lung(6)|ovary(1)|prostate(1)	16						CACCGCTTTGGCATGGAAAAC	0.473000													12	35					0	0	1	0	0
ZNF680	340252	broad.mit.edu	37	7	63981662	63981662	+	Silent	SNP	G	G	A			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr7:63981662G>A	ENST00000309683.6	-	4	1621	c.1470C>T	c.(1468-1470)taC>taT	p.Y490Y		NM_178558.4	NP_848653.2	Q8NEM1	ZN680_HUMAN	zinc finger protein 680	490					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(11)|ovary(1)|prostate(1)	27		Lung NSC(55;0.118)|all_lung(88;0.243)				CTTCACATTTGTAGGGTTTCT	0.383000													6	102					0	0	1	0	0
MRPL36	64979	broad.mit.edu	37	5	1798835	1798835	+	Missense_Mutation	SNP	A	A	G			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr5:1798835A>G	ENST00000508987.1	-	2	351	c.215T>C	c.(214-216)cTt>cCt	p.L72P	MRPL36_ENST00000382647.7_Missense_Mutation_p.L72P|MRPL36_ENST00000505818.1_Missense_Mutation_p.L72P|MRPL36_ENST00000505059.2_Missense_Mutation_p.L72P			Q9P0J6	RM36_HUMAN	mitochondrial ribosomal protein L36	72					translation	mitochondrial large ribosomal subunit	structural constituent of ribosome			breast(1)|lung(2)	3				GBM - Glioblastoma multiforme(108;0.241)		GCGCTTCTTAAGGACAGTCTT	0.592000													8	365					0	0	1	0	0
RGPD3	653489	broad.mit.edu	37	2	107049681	107049681	+	Missense_Mutation	SNP	T	T	C			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr2:107049681T>C	ENST00000409886.3	-	16	2353	c.2266A>G	c.(2266-2268)Aac>Gac	p.N756D	RGPD3_ENST00000304514.7_Missense_Mutation_p.N756D	NM_001144013.1	NP_001137485.1	A6NKT7	RGPD3_HUMAN	RANBP2-like and GRIP domain containing 3	756					intracellular transport		binding	p.N756D(6)		breast(2)|central_nervous_system(1)|endometrium(50)|kidney(4)|lung(11)|ovary(1)|urinary_tract(2)	71						TCACTATAGTTTTCGAGTTCC	0.373000													4	194					0	0	1	0	0
NR1H3	10062	broad.mit.edu	37	11	47282969	47282969	+	Missense_Mutation	SNP	G	G	A			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr11:47282969G>A	ENST00000467728.1	+	4	1915	c.677G>A	c.(676-678)cGg>cAg	p.R226Q	NR1H3_ENST00000481889.2_Missense_Mutation_p.R181Q|NR1H3_ENST00000405853.3_Missense_Mutation_p.R226Q|NR1H3_ENST00000527949.1_Missense_Mutation_p.R135Q|NR1H3_ENST00000405576.1_Missense_Mutation_p.R181Q|NR1H3_ENST00000529540.1_3'UTR|NR1H3_ENST00000441012.2_Missense_Mutation_p.R226Q|NR1H3_ENST00000395397.3_Missense_Mutation_p.R181Q|NR1H3_ENST00000407404.1_Missense_Mutation_p.R226Q			Q13133	NR1H3_HUMAN	nuclear receptor subfamily 1, group H, member 3	226	Ligand-binding (Potential).				apoptotic cell clearance|cellular response to lipopolysaccharide|cholesterol homeostasis|negative regulation of cholesterol storage|negative regulation of inflammatory response|negative regulation of interferon-gamma-mediated signaling pathway|negative regulation of lipid transport|negative regulation of macrophage activation|negative regulation of pancreatic juice secretion|negative regulation of pinocytosis|negative regulation of secretion of lysosomal enzymes|negative regulation of transcription from RNA polymerase II promoter|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of cholesterol homeostasis|positive regulation of fatty acid biosynthetic process|positive regulation of lipoprotein lipase activity|positive regulation of receptor biosynthetic process|positive regulation of toll-like receptor 4 signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of triglyceride biosynthetic process|regulation of circadian rhythm|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|response to progesterone stimulus|triglyceride homeostasis	nuclear chromatin|nucleoplasm	cholesterol binding|steroid hormone receptor activity|sterol response element binding|transcription coactivator activity|zinc ion binding	p.R226Q(1)		endometrium(1)|kidney(2)|large_intestine(6)|lung(6)|ovary(5)	20						CAGTGTAACCGGCGCTCCTTT	0.622000													25	60					0	0	1	0	0
UGT3A1	133688	broad.mit.edu	37	5	35954581	35954581	+	Splice_Site	SNP	C	C	T			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr5:35954581C>T	ENST00000274278.3	-	7	1653		c.e7-1			NM_152404.3	NP_689617.3	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1							integral to membrane	glucuronosyltransferase activity			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(8)|lung(28)|ovary(2)|skin(4)	46	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			CGACTTGTACCTGTTGGCGGA	0.547000													6	26					0	0	1	0	0
MAEL	84944	broad.mit.edu	37	1	166962019	166962019	+	Missense_Mutation	SNP	G	G	A			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr1:166962019G>A	ENST00000367872.4	+	4	666	c.422G>A	c.(421-423)tGt>tAt	p.C141Y	MAEL_ENST00000491055.1_3'UTR|MAEL_ENST00000367870.2_Missense_Mutation_p.C110Y	NM_032858.1	NP_116247.1	Q96JY0	MAEL_HUMAN	maelstrom spermatogenic transposon silencer	141					cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(12)|skin(4)	28						GAAATTGGCTGTGTTAAGTAT	0.398000													21	87					0	0	1	0	0
PHLPP2	23035	broad.mit.edu	37	16	71701133	71701133	+	Nonsense_Mutation	SNP	G	G	A			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr16:71701133G>A	ENST00000393524.2	-	11	2465	c.1732C>T	c.(1732-1734)Cag>Tag	p.Q578*	PHLPP2_ENST00000360429.3_Nonsense_Mutation_p.Q578*|PHLPP2_ENST00000356272.3_Nonsense_Mutation_p.Q578*|PHLPP2_ENST00000568954.1_Nonsense_Mutation_p.Q578*|PHLPP2_ENST00000567016.1_Nonsense_Mutation_p.Q613*			Q6ZVD8	PHLP2_HUMAN	PH domain and leucine rich repeat protein phosphatase 2	652						cytoplasm|membrane|nucleus	metal ion binding|phosphoprotein phosphatase activity			central_nervous_system(1)|endometrium(5)|kidney(5)|large_intestine(7)|lung(15)|ovary(1)|prostate(1)|skin(1)|stomach(1)	37						GCATTATGCTGAAGATCCAGC	0.463000													24	43					0	0	1	0	0
DCTN2	10540	broad.mit.edu	37	12	57924490	57924490	+	Missense_Mutation	SNP	C	C	T			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr12:57924490C>T	ENST00000548249.1	-	14	1455	c.1188G>A	c.(1186-1188)atG>atA	p.M396I	DCTN2_ENST00000543672.1_Missense_Mutation_p.M401I|DCTN2_ENST00000537439.1_Missense_Mutation_p.M373I|DCTN2_ENST00000434715.3_Missense_Mutation_p.M401I	NM_001261412.1|NM_001261413.1	NP_001248341.1|NP_001248342.1	Q13561	DCTN2_HUMAN	dynactin 2 (p50)	396					cell proliferation|G2/M transition of mitotic cell cycle|mitosis	centrosome|cytosol|dynactin complex|dynein complex|kinetochore|membrane|microtubule|vesicle	motor activity|protein binding			endometrium(1)|large_intestine(4)|lung(2)|ovary(2)|upper_aerodigestive_tract(2)	11						CCAGCTTCTTCATCCGTTCAT	0.478000													58	39					0	0	1	0	0
MT-CO3	4514	broad.mit.edu	37	MT	9367	9367	+	Missense_Mutation	SNP	T	T	C			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chrM:9367T>C	ENST00000362079.2	+	1	161	c.161T>C	c.(160-162)aTa>aCa	p.54_54insT						mitochondrially encoded cytochrome c oxidase III											breast(1)|endometrium(10)|kidney(14)|lung(1)|urinary_tract(1)	27						CACACTAACCATATACCAATG	0.498000													76	68					0	0	1	0	0
RB1	5925	broad.mit.edu	37	13	48881414	48881414	+	Splice_Site	SNP	A	A	G			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr13:48881414A>G	ENST00000267163.4	+	2	275		c.e2-1			NM_000321.2	NP_000312.2	P06400	RB_HUMAN	retinoblastoma 1						androgen receptor signaling pathway|cell cycle arrest|chromatin remodeling|G1 phase of mitotic cell cycle|interspecies interaction between organisms|maintenance of mitotic sister chromatid cohesion|mitotic cell cycle G1/S transition checkpoint|myoblast differentiation|negative regulation of cell growth|negative regulation of protein kinase activity|negative regulation of S phase of mitotic cell cycle|negative regulation of sequence-specific DNA binding transcription factor activity|positive regulation of mitotic metaphase/anaphase transition|protein localization to chromosome, centromeric region|Ras protein signal transduction|regulation of centromere complex assembly|regulation of cohesin localization to chromatin|regulation of lipid kinase activity|regulation of transcription involved in G1/S phase of mitotic cell cycle|S phase of mitotic cell cycle|sister chromatid biorientation	chromatin|PML body|Rb-E2F complex|SWI/SNF complex	androgen receptor binding|DNA binding|kinase binding|phosphoprotein binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription factor binding|ubiquitin protein ligase binding	p.0?(15)|p.?(1)		NS(3)|adrenal_gland(1)|bone(22)|breast(30)|central_nervous_system(48)|cervix(3)|endometrium(14)|eye(95)|gastrointestinal_tract_(site_indeterminate)(1)|haematopoietic_and_lymphoid_tissue(20)|kidney(3)|large_intestine(10)|liver(3)|lung(153)|oesophagus(1)|ovary(13)|pancreas(5)|pituitary(1)|prostate(14)|salivary_gland(2)|skin(9)|soft_tissue(9)|stomach(4)|upper_aerodigestive_tract(1)|urinary_tract(31)	496		all_cancers(8;6.9e-71)|all_epithelial(8;4.61e-22)|Acute lymphoblastic leukemia(8;1.1e-21)|all_hematologic(8;2.3e-21)|all_lung(13;1.51e-09)|Lung NSC(96;7.03e-07)|Breast(56;1.53e-05)|Prostate(109;0.000493)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|all_neural(104;0.0227)|Glioma(44;0.0286)|Lung SC(185;0.0301)		GBM - Glioblastoma multiforme(2;9.98e-18)|LUSC - Lung squamous cell carcinoma(3;0.013)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	TTCATTTGGTAGGCTTGAGTT	0.313000		6	"""D, Mis, N, F, S"""		"""retinoblastoma, sarcoma, breast, small cell lung"""	"""retinoblastoma, sarcoma, breast, small cell lung"""			Hereditary Retinoblastoma	TCGA GBM(7;6.82e-08)|TSP Lung(12;0.097)|TCGA Ovarian(6;0.080)			21	2					0	0	1	0	0
SERPINA6	866	broad.mit.edu	37	14	94770860	94770860	+	Silent	SNP	C	C	T			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr14:94770860C>T	ENST00000341584.3	-	5	1259	c.1113G>A	c.(1111-1113)acG>acA	p.T371T		NM_001756.3	NP_001747.2	P08185	CBG_HUMAN	serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6	371					regulation of proteolysis|transport	extracellular space	serine-type endopeptidase inhibitor activity|steroid binding			central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(11)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	26		all_cancers(154;0.0482)|all_epithelial(191;0.166)		COAD - Colon adenocarcinoma(157;0.211)	Alclometasone(DB00240)|Beclomethasone(DB00394)|Ciclesonide(DB01410)|Flumethasone Pivalate(DB00663)|Flunisolide(DB00180)|Fluocinolone Acetonide(DB00591)|Fluocinonide(DB01047)|Fluorometholone(DB00324)|Flurandrenolide(DB00846)|Fluticasone Propionate(DB00588)|Halobetasol Propionate(DB00596)|Medrysone(DB00253)|Mitotane(DB00648)|Paramethasone(DB01384)|Prednisolone(DB00860)|Rimexolone(DB00896)|Triamcinolone(DB00620)	TAGGCTTGGACGTCAGGTTTA	0.522000													36	19					0	0	1	0	0
AGMO	392636	broad.mit.edu	37	7	15405139	15405139	+	Splice_Site	SNP	C	C	A			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr7:15405139C>A	ENST00000342526.3	-	12	1432	c.1263_splice	c.e12+1	p.E421_splice		NM_001004320.1	NP_001004320.1	Q6ZNB7	ALKMO_HUMAN	alkylglycerol monooxygenase	421					ether lipid metabolic process|fatty acid biosynthetic process|membrane lipid metabolic process	endoplasmic reticulum membrane|integral to membrane	glyceryl-ether monooxygenase activity|iron ion binding			breast(1)|kidney(1)|large_intestine(6)|liver(1)|lung(30)|prostate(1)|skin(2)	42						AATGTCTTACCTCAAAAGCAG	0.408000													30	34					7.26314e-15	8.16239e-15	1	1	0
IRX2	153572	broad.mit.edu	37	5	2749656	2749656	+	Missense_Mutation	SNP	G	G	C			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr5:2749656G>C	ENST00000382611.6	-	2	743	c.495C>G	c.(493-495)ttC>ttG	p.F165L	IRX2_ENST00000302057.5_Missense_Mutation_p.F165L|IRX2_ENST00000502957.1_5'UTR	NM_001134222.1	NP_001127694.1	Q9BZI1	IRX2_HUMAN	iroquois homeobox 2	165						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(1)|central_nervous_system(3)|endometrium(4)|kidney(1)|large_intestine(2)|lung(12)|prostate(1)|skin(2)	26				GBM - Glioblastoma multiforme(108;0.204)		GCGCGTTGGCGAACCAGGTGG	0.597000													47	873					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577097	7577097	+	Missense_Mutation	SNP	C	C	T			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr17:7577097C>T	ENST00000420246.2	-	8	973	c.841G>A	c.(841-843)Gac>Aac	p.D281N	TP53_ENST00000269305.4_Missense_Mutation_p.D281N|TP53_ENST00000455263.2_Missense_Mutation_p.D281N|TP53_ENST00000359597.4_Missense_Mutation_p.D281N|TP53_ENST00000445888.2_Missense_Mutation_p.D281N|TP53_ENST00000413465.2_Intron	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	281	Interaction with AXIN1 (By similarity).|Interaction with E4F1.|Interaction with HIPK1 (By similarity).		D -> A (in sporadic cancers; somatic mutation).|D -> E (in sporadic cancers; somatic mutation).|D -> G (in a brain tumor with no family history; germline mutation and in sporadic cancers; somatic mutation).|D -> H (in sporadic cancers; somatic mutation).|D -> N (in LFS; germline mutation and in sporadic cancers; somatic mutation).|D -> R (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|D -> V (in a familial cancer not matching LFS; germline mutation and in sporadic cancers; somatic mutation).|D -> Y (in sporadic cancers; somatic mutation).|DR -> EW (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.D281N(25)|p.D281H(19)|p.D281Y(16)|p.0?(8)|p.?(2)|p.R280_D281delRD(2)|p.D281>AGPY(2)|p.A276_R283delACPGRDRR(1)|p.D281R(1)|p.C275fs*20(1)|p.A276fs*64(1)|p.L265_K305del41(1)|p.D281_R282delDR(1)|p.F270_D281del12(1)|p.G279fs*59(1)|p.R280fs*62(1)|p.S269fs*21(1)|p.V272_K292del21(1)|p.C275_R283delCACPGRDRR(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GTGCGCCGGTCTCTCCCAGGA	0.547000		111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			18	5					0	0	1	0	0
HIST1H2BJ	8970	broad.mit.edu	37	6	27100485	27100485	+	Silent	SNP	G	G	A	rs115912638	by1000genomes	TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr6:27100485G>A	ENST00000607124.1	-	1	44	c.45C>T	c.(43-45)tcC>tcT	p.S15S	HIST1H2BJ_ENST00000339812.2_Silent_p.S15S|HIST1H2BJ_ENST00000541790.1_Silent_p.S15S			P06899	H2B1J_HUMAN	histone cluster 1, H2bj	15					defense response to bacterium|nucleosome assembly	nucleosome|nucleus	DNA binding			breast(1)|kidney(2)|lung(5)|ovary(1)|prostate(1)	10						CCGCCTTCTTGGAGCCCTTTT	0.537000													41	160					0	0	1	0	0
APCDD1	147495	broad.mit.edu	37	18	10487757	10487757	+	Missense_Mutation	SNP	G	G	A			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr18:10487757G>A	ENST00000355285.4	+	5	1621	c.1267G>A	c.(1267-1269)Gag>Aag	p.E423K		NM_153000.4	NP_694545.1	Q8J025	APCD1_HUMAN	adenomatosis polyposis coli down-regulated 1	423					hair follicle development|negative regulation of Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to plasma membrane	Wnt-protein binding			NS(1)|breast(1)|endometrium(3)|large_intestine(5)|lung(7)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	22				READ - Rectum adenocarcinoma(15;0.08)		CACGGAGTACGAGATCTTCAA	0.627000													27	167					0	0	1	0	0
ZBTB11	27107	broad.mit.edu	37	3	101395550	101395550	+	Missense_Mutation	SNP	C	C	T			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr3:101395550C>T	ENST00000312938.4	-	1	789	c.209G>A	c.(208-210)cGa>cAa	p.R70Q	ZBTB11_ENST00000461821.1_Missense_Mutation_p.R70Q|ZBTB11-AS1_ENST00000536865.1_Missense_Mutation_p.S21L	NM_014415.3	NP_055230.2	O95625	ZBT11_HUMAN	zinc finger and BTB domain containing 11	70					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(7)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	37						GTCCCGGCGTCGCTCCGGCTG	0.692000													13	1					0	0	1	0	0
C10orf2	56652	broad.mit.edu	37	10	102748377	102748377	+	Missense_Mutation	SNP	G	G	T			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr10:102748377G>T	ENST00000370228.1	+	1	595	c.410G>T	c.(409-411)aGg>aTg	p.R137M	C10orf2_ENST00000311916.2_Missense_Mutation_p.R137M|C10orf2_ENST00000473656.1_Intron	NM_001163812.1|NM_001163814.1	NP_001157284.1|NP_001157286.1	Q96RR1	PEO1_HUMAN	chromosome 10 open reading frame 2	137					cell death|mitochondrial DNA replication|protein hexamerization|protein homooligomerization|transcription from mitochondrial promoter	mitochondrial nucleoid	5'-3' DNA helicase activity|ATP binding|protease binding|single-stranded DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(10)|ovary(1)|skin(1)|stomach(1)	24		Colorectal(252;0.122)|all_hematologic(284;0.152)		Epithelial(162;7.18e-11)|all cancers(201;8.75e-09)|BRCA - Breast invasive adenocarcinoma(275;0.224)		GATGGGGCCAGGGAGGGGTTT	0.592000													15	255					0.000422831	0.000449496	1	1	0
TOX	9760	broad.mit.edu	37	8	59728107	59728107	+	Missense_Mutation	SNP	C	C	A			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr8:59728107C>A	ENST00000361421.1	-	7	1402	c.1182G>T	c.(1180-1182)agG>agT	p.R394S		NM_014729.2	NP_055544.1	O94900	TOX_HUMAN	thymocyte selection-associated high mobility group box	394						nucleus	DNA binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(13)|prostate(1)|skin(2)|stomach(1)	33		all_cancers(86;0.165)|Myeloproliferative disorder(644;0.00452)|all_lung(136;0.036)|Lung NSC(129;0.0464)|all_epithelial(80;0.0607)				GGGCTATGTTCCTGGGGAGAC	0.567000													25	50					1.55469e-16	1.76398e-16	1	1	0
CNTNAP4	85445	broad.mit.edu	37	16	76587181	76587181	+	Splice_Site	SNP	A	A	G			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr16:76587181A>G	ENST00000307431.8	+	23	3826	c.3439_splice	c.e23-1	p.E1147_splice	CNTNAP4_ENST00000469589.1_3'UTR|CNTNAP4_ENST00000377504.4_Splice_Site_p.E1099_splice|CNTNAP4_ENST00000476707.1_Splice_Site_p.E1151_splice|CNTNAP4_ENST00000478060.1_Splice_Site_p.E1075_splice	NM_033401.3	NP_207837.2	Q9C0A0	CNTP4_HUMAN	contactin associated protein-like 4	1148	Laminin G-like 4.				cell adhesion|signal transduction	integral to membrane	receptor binding			breast(4)|central_nervous_system(1)|cervix(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(6)|lung(33)|ovary(2)|pancreas(1)|prostate(3)|upper_aerodigestive_tract(1)	64						AATTTCTAGAACACAGTGATG	0.478000													6	8					0	0	1	0	0
OR9G1	390174	broad.mit.edu	37	11	56468604	56468604	+	Silent	SNP	C	C	A			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr11:56468604C>A	ENST00000312153.1	+	1	741	c.741C>A	c.(739-741)gtC>gtA	p.V247V		NM_001005213.1	NP_001005213.1			olfactory receptor, family 9, subfamily G, member 1											breast(2)|kidney(1)|lung(25)|stomach(2)|upper_aerodigestive_tract(1)	31						TGACCTCTGTCACTTTATACT	0.453000													36	211					2.20474e-14	2.45433e-14	1	1	0
GTF3C1	2975	broad.mit.edu	37	16	27503992	27503992	+	Silent	SNP	G	G	A			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr16:27503992G>A	ENST00000356183.4	-	18	2934	c.2919C>T	c.(2917-2919)tgC>tgT	p.C973C	GTF3C1_ENST00000561623.1_Silent_p.C973C	NM_001520.3	NP_001511.2	Q12789	TF3C1_HUMAN	general transcription factor IIIC, polypeptide 1, alpha 220kDa	973						transcription factor TFIIIC complex	DNA binding|protein binding			breast(2)|central_nervous_system(4)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(14)|liver(3)|lung(28)|ovary(2)|pancreas(1)|prostate(2)|skin(5)|upper_aerodigestive_tract(2)	80						GCCCCATGTAGCACAGCCTCT	0.512000													83	80					0	0	1	0	0
SPTBN4	57731	broad.mit.edu	37	19	41072112	41072112	+	Silent	SNP	T	T	C			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr19:41072112T>C	ENST00000352632.3	+	30	6269	c.6183T>C	c.(6181-6183)gaT>gaC	p.D2061D	SPTBN4_ENST00000338932.3_Silent_p.D2061D|SPTBN4_ENST00000392025.1_Silent_p.D804D|SPTBN4_ENST00000598249.1_Silent_p.D2061D			Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4	2061					actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			breast(4)|central_nervous_system(1)|endometrium(6)|kidney(7)|large_intestine(9)|lung(32)|ovary(3)|prostate(2)|skin(5)|upper_aerodigestive_tract(3)|urinary_tract(1)	73			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			TGGTGGCTGATGCCTGGCTGA	0.667000													4	4					0	0	1	0	0
RP11-417J8.6	0	broad.mit.edu	37	1	142648461	142648462	+	RNA	INS	-	-	T	rs149586890		TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr1:142648461_142648462insT	ENST00000369381.2	-	0	2507				RP11-417J8.3_ENST00000426408.1_lincRNA																							taatttttgtattttttttttg	0.475													4	2	---	---	---	---					
RP11-403I13.4	0	broad.mit.edu	37	1	149250552	149250553	+	RNA	INS	-	-	A			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr1:149250552_149250553insA	ENST00000325963.8	+	0	597_598																											AAACTGAGAAGAAAAAAAAAGA	0.416													2	4	---	---	---	---					
KIF14	9928	broad.mit.edu	37	1	200584490	200584491	+	Frame_Shift_Ins	INS	-	-	T			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr1:200584490_200584491insT	ENST00000367350.4	-	3	1797_1798	c.1359_1360insA	c.(1357-1362)aacatafs	p.NI453fs		NM_014875.2	NP_055690.1	Q15058	KIF14_HUMAN	kinesin family member 14	453	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			NS(1)|breast(5)|central_nervous_system(2)|endometrium(8)|kidney(8)|large_intestine(15)|lung(13)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	61						TACGTATATGATTTTCCAGAGC	0.381													38	50	---	---	---	---					
TAF1B	9014	broad.mit.edu	37	2	9989571	9989571	+	Frame_Shift_Del	DEL	A	A	-			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr2:9989571delA	ENST00000263663.5	+	3	375	c.187delA	c.(187-189)aafs	p.K65fs	TAF1B_ENST00000402170.1_3'UTR|TAF1B_ENST00000396242.3_5'UTR	NM_005680.2	NP_005671.2	Q53T94	TAF1B_HUMAN	TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa	65					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	nucleoplasm	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|lung(4)|ovary(2)|pancreas(1)|prostate(1)|upper_aerodigestive_tract(1)	14	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					CCGGGGGCTTAAAAAAAAAAA	0.333													4	7	---	---	---	---					
HAT1	8520	broad.mit.edu	37	2	172822005	172822007	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr2:172822005_172822007delAGG	ENST00000264108.4	+	5	492_494	c.456_458delAGG	c.(454-459)aca>ac	p.TG152del	HAT1_ENST00000392584.1_In_Frame_Del_p.TG67del|SLC25A12_ENST00000472748.1_Intron	NM_003642.3	NP_003633.1	O14929	HAT1_HUMAN	histone acetyltransferase 1	152					chromatin silencing at telomere|DNA packaging	cytoplasm|nuclear matrix|nucleoplasm	histone acetyltransferase activity|protein binding			breast(1)|kidney(1)|large_intestine(5)|liver(2)|lung(8)|ovary(1)|prostate(1)	19			OV - Ovarian serous cystadenocarcinoma(117;0.216)			TCAGTCCAACAGGAGGAGAAAAC	0.335													8	22	---	---	---	---					
AC128709.2	0	broad.mit.edu	37	3	197186847	197186847	+	RNA	DEL	G	G	-			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr3:197186847delG	ENST00000420213.1	+	0	138																											GCGGTCGGGAGGGGATGCAGT	0.607													2	4	---	---	---	---					
TET2	54790	broad.mit.edu	37	4	106157271	106157271	+	Frame_Shift_Del	DEL	T	T	-			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr4:106157271delT	ENST00000513237.1	+	3	3032	c.2235delT	c.(2233-2235)cafs	p.H745fs	TET2_ENST00000380013.4_Frame_Shift_Del_p.H724fs|TET2_ENST00000305737.2_Frame_Shift_Del_p.H724fs|TET2_ENST00000413648.2_Frame_Shift_Del_p.H724fs|TET2_ENST00000545826.1_Frame_Shift_Del_p.H724fs|TET2_ENST00000394764.1_Frame_Shift_Del_p.H724fs|TET2_ENST00000540549.1_Frame_Shift_Del_p.H724fs			Q6N021	TET2_HUMAN	tet methylcytosine dioxygenase 2	724	Gln-rich.				cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	p.H724fs*29(1)		NS(1)|breast(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1272)|kidney(3)|large_intestine(11)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	1314		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		ATAAGCCTCATAAACAGGCAG	0.408			"""Mis N, F"""		MDS								20	22	---	---	---	---					
CTD-2587M23.1	0	broad.mit.edu	37	5	1726293	1726293	+	RNA	DEL	G	G	-	rs60032713		TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr5:1726293delG	ENST00000565428.1	+	0	1030																											GCCCTCCTCCGCCGTTCCGCC	0.612													7	0	---	---	---	---					
GUSBP1	0	broad.mit.edu	37	5	21481564	21481564	+	RNA	DEL	G	G	-	rs139480853	by1000genomes	TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr5:21481564delG	ENST00000607545.1	+	0	179					NR_027026.1																						GCAGGTGTGAGGGGGGCAGGA	0.527													2	4	---	---	---	---					
HOXA1	3198	broad.mit.edu	37	7	27135314	27135316	+	In_Frame_Del	DEL	CGA	CGA	-	rs10951154	byFrequency	TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr7:27135314_27135316delCGA	ENST00000343060.4	-	1	277_279	c.216_218delTCG	c.(214-219)cac>ca	p.HR72del	HOTAIRM1_ENST00000495032.1_RNA|HOXA1_ENST00000355633.5_In_Frame_Del_p.HR72del	NM_005522.4	NP_005513.1	P49639	HXA1_HUMAN	homeobox A1	72	Poly-His.					nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|kidney(2)|large_intestine(4)|liver(1)|lung(14)|ovary(4)|prostate(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						Ctgggggtggcgatggtggtggt	0.650											OREG0003750	type=REGULATORY REGION|Gene=BC031342|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	7	167	---	---	---	---					
HOXA11-AS	0	broad.mit.edu	37	7	27228108	27228108	+	RNA	DEL	T	T	-			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr7:27228108delT	ENST00000522863.1	+	0	1156				HOXA11-AS_ENST00000522674.1_RNA|HOXA11-AS_ENST00000479766.1_RNA|HOXA11-AS_ENST00000520360.1_RNA|RP1-170O19.14_ENST00000523331.1_lincRNA																							GGGCGAGGGGTGGGCGCAGCT	0.567													2	4	---	---	---	---					
FOXD4	2298	broad.mit.edu	37	9	117406	117407	+	Frame_Shift_Ins	INS	-	-	G			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr9:117406_117407insG	ENST00000382500.2	-	1	1010_1011	c.713_714insC	c.(712-714)cccfs	p.P238fs		NM_207305.4	NP_997188.2	Q12950	FOXD4_HUMAN	forkhead box D4	238	Pro-rich.				axon extension involved in axon guidance|cartilage development|dichotomous subdivision of terminal units involved in ureteric bud branching|embryo development|enteric nervous system development|iridophore differentiation|lateral line nerve glial cell development|melanocyte differentiation|neural crest cell migration|pattern specification process|peripheral nervous system development|positive regulation of BMP signaling pathway|positive regulation of kidney development|positive regulation of transcription from RNA polymerase II promoter|regulation of sequence-specific DNA binding transcription factor activity|sympathetic nervous system development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(5)|large_intestine(2)|lung(3)|prostate(1)|skin(3)	14	all_lung(41;0.218)	all_cancers(5;0.0395)|Acute lymphoblastic leukemia(5;1.91e-07)|all_hematologic(5;1.95e-06)	Kidney(42;0.112)|KIRC - Kidney renal clear cell carcinoma(5;0.157)	all cancers(5;0.000704)|Lung(218;0.00755)|GBM - Glioblastoma multiforme(5;0.0149)|Epithelial(6;0.0154)		CTGGCTGCGGCGGGGCAGGGGC	0.743													7	125	---	---	---	---					
RP11-262H14.1	0	broad.mit.edu	37	9	66460027	66460027	+	RNA	DEL	T	T	-	rs112286776		TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr9:66460027delT	ENST00000424345.1	+	0	224																											ttgggaaggcttttcacatat	0.343													2	4	---	---	---	---					
RP11-764K9.1	0	broad.mit.edu	37	9	68406251	68406251	+	RNA	DEL	A	A	-			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr9:68406251delA	ENST00000417843.2	-	0	224																											atcaatggggaaaagattccc	0.378													3	5	---	---	---	---					
SEC23IP	11196	broad.mit.edu	37	10	121668600	121668601	+	Frame_Shift_Del	DEL	AG	AG	-			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr10:121668600_121668601delAG	ENST00000369075.3	+	5	1221_1222	c.1149_1150delAG	c.(1147-1152)ttagfs	p.LE383fs	SEC23IP_ENST00000543134.1_Frame_Shift_Del_p.LE172fs	NM_007190.3	NP_009121.1	Q9Y6Y8	S23IP_HUMAN	SEC23 interacting protein	383					Golgi organization|intracellular protein transport	endoplasmic reticulum|ER to Golgi transport vesicle membrane|ER-Golgi intermediate compartment	metal ion binding			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(12)|ovary(3)|prostate(1)|stomach(3)|urinary_tract(1)	36		Lung NSC(174;0.109)|all_lung(145;0.142)|all_neural(114;0.234)		all cancers(201;0.00515)		ACCGAAGATTAGAGTTTCCAAG	0.327													11	49	---	---	---	---					
RP11-1028N23.4	0	broad.mit.edu	37	12	116058638	116058638	+	RNA	DEL	G	G	-			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr12:116058638delG	ENST00000551940.1	-	0	90																											AGGCCAGGCTGGGGCTCATGG	0.537													2	4	---	---	---	---					
LINC00511	0	broad.mit.edu	37	17	70623821	70623821	+	RNA	DEL	A	A	-			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr17:70623821delA	ENST00000581549.1	-	0	206					NR_033876.1																						aaactgcctgaaaaaaaaaga	0.423													2	4	---	---	---	---					
LINC00669	0	broad.mit.edu	37	18	36841508	36841509	+	RNA	DEL	AC	AC	-			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr18:36841508_36841509delAC	ENST00000591629.1	-	0	440					NR_024391.1																						atattgaagtacacagaccagt	0.376													2	4	---	---	---	---					
RP4-777D9.2	0	broad.mit.edu	37	20	21142454	21142455	+	RNA	INS	-	-	C	rs45603533	by1000genomes	TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr20:21142454_21142455insC	ENST00000591761.1	-	0	5142				PLK1S1_ENST00000457464.1_RNA|RP5-872K7.7_ENST00000425746.2_RNA																							AAAAAAAAAAACCCCACCTAAT	0.376													7	13	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11046071	11046078	+	RNA	DEL	AAAAAAAC	AAAAAAAC	-	rs144620563		TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr21:11046071_11046078delAAAAAAAC	ENST00000470054.1	-	0	774									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GCACAACTTAAAAAAAACAAAGTTATTC	0.264													2	4	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11065194	11065197	+	RNA	DEL	AGAG	AGAG	-			TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr21:11065194_11065197delAGAG	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		gaccttaaacagagagcacagttg	0.426													4	8	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11072706	11072706	+	RNA	DEL	A	A	-	rs150219169		TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr21:11072706delA	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		tgaactgattaaaaaaaaaaa	0.393													4	6	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11072716	11072717	+	RNA	INS	-	-	C	rs80212457	by1000genomes	TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr21:11072716_11072717insC	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		aaaaaaaaaaaaaaacagtggc	0.421													6	6	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11080670	11080673	+	RNA	DEL	AGAG	AGAG	-	rs3954670		TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr21:11080670_11080673delAGAG	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GTAAAGACACAGAGAGAGAGACTT	0.485													5	4	---	---	---	---					
AP003900.6	0	broad.mit.edu	37	21	11175282	11175283	+	RNA	INS	-	-	G	rs56073885		TCGA-N5-A4RN-01A-12D-A28R-08	TCGA-N5-A4RN-10A-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	16e9dbc9-970e-4862-ae7b-385f9cff0a1e	d81a5759-35b0-4357-9879-2ef15a12f84b	g.chr21:11175282_11175283insG	ENST00000603265.1	+	0	231																											GATCATCTGTAGTGTACGGTGG	0.391													6	0	---	---	---	---					
