Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GMPPA	29926	broad.mit.edu	37	2	220370460	220370460	+	Missense_Mutation	SNP	G	G	A	rs151043830		TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr2:220370460G>A	ENST00000358215.3	+	10	1246	c.877G>A	c.(877-879)Gcc>Acc	p.A293T	AC053503.11_ENST00000429882.1_RNA|GMPPA_ENST00000341142.3_Missense_Mutation_p.A293T|GMPPA_ENST00000373908.1_Missense_Mutation_p.A293T|GMPPA_ENST00000373917.3_Missense_Mutation_p.A346T|GMPPA_ENST00000313597.5_Missense_Mutation_p.A293T	NM_205847.2	NP_995319.1	Q96IJ6	GMPPA_HUMAN	GDP-mannose pyrophosphorylase A	293					dolichol-linked oligosaccharide biosynthetic process|GDP-mannose biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine		GTP binding|mannose-1-phosphate guanylyltransferase activity			breast(2)|central_nervous_system(1)|endometrium(2)|large_intestine(7)|lung(6)|prostate(1)|skin(1)	20		Renal(207;0.0183)		Epithelial(149;3.82e-10)|all cancers(144;6.25e-08)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00807)|READ - Rectum adenocarcinoma(5;0.148)		CCACCCGACCGCCAAGGTGGC	0.607000													18	27					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21245884	21245884	+	Missense_Mutation	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr2:21245884C>T	ENST00000233242.1	-	18	2762	c.2635G>A	c.(2635-2637)Gtg>Atg	p.V879M		NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	879					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	TCCACAGACACGGAGGGTTTT	0.478000													25	43					0	0	1	0	0
TPO	7173	broad.mit.edu	37	2	1457506	1457506	+	Nonsense_Mutation	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr2:1457506C>T	ENST00000345913.4	+	6	614	c.523C>T	c.(523-525)Cga>Tga	p.R175*	TPO_ENST00000382198.1_Nonsense_Mutation_p.R175*|TPO_ENST00000497517.2_Intron|TPO_ENST00000382201.3_Nonsense_Mutation_p.R175*|TPO_ENST00000329066.4_Nonsense_Mutation_p.R175*|TPO_ENST00000349624.3_Nonsense_Mutation_p.R175*|TPO_ENST00000346956.3_Nonsense_Mutation_p.R175*|TPO_ENST00000337415.3_Nonsense_Mutation_p.R175*	NM_000547.5	NP_000538.3	P07202	PERT_HUMAN	thyroid peroxidase	175					cellular nitrogen compound metabolic process|hormone biosynthetic process|hydrogen peroxide catabolic process	cell surface|cytoplasm|integral to plasma membrane	calcium ion binding|heme binding|iodide peroxidase activity			breast(1)|central_nervous_system(3)|endometrium(8)|kidney(4)|large_intestine(14)|liver(2)|lung(33)|ovary(8)|pancreas(6)|prostate(4)|skin(7)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	95	all_hematologic(175;0.0487)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.0338)		all cancers(51;0.0356)|OV - Ovarian serous cystadenocarcinoma(76;0.0748)|Epithelial(75;0.12)	Carbimazole(DB00389)|Methimazole(DB00763)|Propylthiouracil(DB00550)	GGCCCTGGCACGATGGCTCCC	0.602000													31	40					0	0	1	0	0
RP11-262H14.1	0	broad.mit.edu	37	9	66457535	66457535	+	RNA	SNP	T	T	C	rs74360065		TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr9:66457535T>C	ENST00000424345.1	+	0	67																											TGTTTGCTTCTTTCTGTCTCC	0.562000													3	7					0	0	1	0	0
ACSF3	197322	broad.mit.edu	37	16	89167646	89167646	+	Missense_Mutation	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr16:89167646C>T	ENST00000317447.4	+	3	934	c.557C>T	c.(556-558)cCg>cTg	p.P186L	ACSF3_ENST00000378345.4_Intron|ACSF3_ENST00000406948.3_Missense_Mutation_p.P186L	NM_001127214.2|NM_001243279.1|NM_174917.3	NP_001120686.1|NP_001230208.1|NP_777577.2	Q4G176	ACSF3_HUMAN	acyl-CoA synthetase family member 3	186					fatty acid metabolic process	mitochondrion	acid-thiol ligase activity|ATP binding			central_nervous_system(1)|endometrium(1)|kidney(2)|lung(9)|prostate(1)|urinary_tract(1)	15				BRCA - Breast invasive adenocarcinoma(80;0.0281)		GCAGAGGTCCCGGTCCCAGAG	0.642000													9	7					0	0	1	0	0
RP11-85G18.6	0	broad.mit.edu	37	10	27537159	27537159	+	RNA	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr10:27537159C>T	ENST00000574842.1	+	0	255				LRRC37A6P_ENST00000284414.4_RNA																							GCTCAGTGCTCGTGTGCTTCT	0.493000													45	57					0	0	1	0	0
ZNF655	79027	broad.mit.edu	37	7	99171161	99171161	+	Missense_Mutation	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr7:99171161C>T	ENST00000424881.1	+	4	1755	c.1535C>T	c.(1534-1536)gCa>gTa	p.A512V	ZNF655_ENST00000419215.2_3'UTR|ZNF655_ENST00000425063.1_3'UTR|ZNF655_ENST00000394163.2_Missense_Mutation_p.A477V|ZNF655_ENST00000252713.4_Missense_Mutation_p.A477V|ZNF655_ENST00000493277.1_Missense_Mutation_p.A512V	NM_001083956.1|NM_001085368.1	NP_001077425.1|NP_001078837.1	Q8N720	ZN655_HUMAN	zinc finger protein 655	477					G1 phase|regulation of mitotic cell cycle|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleolus	DNA binding|protein binding|zinc ion binding			NS(1)|kidney(1)|large_intestine(3)|lung(5)|ovary(1)|upper_aerodigestive_tract(1)|urinary_tract(4)	16	all_epithelial(64;3.19e-09)|Lung NSC(181;0.0066)|all_lung(186;0.011)|Esophageal squamous(72;0.0166)					AGTCAGAGAGCACATCTAGTT	0.393000													34	50					0	0	1	0	0
PLEKHA2	59339	broad.mit.edu	37	8	38775463	38775463	+	Missense_Mutation	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr8:38775463C>T	ENST00000420274.1	+	2	250	c.16C>T	c.(16-18)Cgg>Tgg	p.R6W	PLEKHA2_ENST00000388745.4_3'UTR|PLEKHA2_ENST00000521746.1_Missense_Mutation_p.R6W	NM_021623.1	NP_067636.1	Q9HB19	PKHA2_HUMAN	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 2	6					positive regulation of cell-matrix adhesion	cytoplasm|nucleus|plasma membrane|protein complex	fibronectin binding|laminin binding			breast(2)|endometrium(2)|kidney(2)|large_intestine(2)|lung(4)|upper_aerodigestive_tract(1)	13		all_lung(54;0.0413)|Lung NSC(58;0.115)|Hepatocellular(245;0.152)	LUSC - Lung squamous cell carcinoma(45;4.68e-08)|COAD - Colon adenocarcinoma(9;0.235)			TTATGTGGATCGGCAGAACCG	0.562000													24	25					0	0	1	0	0
CALCR	799	broad.mit.edu	37	7	93065414	93065414	+	Silent	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr7:93065414C>T	ENST00000359558.2	-	14	1400	c.1101G>A	c.(1099-1101)gcG>gcA	p.A367A	CALCR_ENST00000394441.1_Silent_p.A333A|CALCR_ENST00000421592.1_Silent_p.A349A|CALCR_ENST00000426151.1_Silent_p.A333A|CALCR_ENST00000360249.4_Silent_p.A349A	NM_001164737.1	NP_001158209.1	P30988	CALCR_HUMAN	calcitonin receptor	349					activation of adenylate cyclase activity by G-protein signaling pathway|elevation of cytosolic calcium ion concentration|positive regulation of adenylate cyclase activity|response to glucocorticoid stimulus	integral to plasma membrane	calcitonin binding|calcitonin receptor activity|protein binding			NS(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(27)|ovary(3)|pancreas(1)|skin(3)	45	all_cancers(62;3.18e-12)|all_epithelial(64;1.34e-11)|Breast(17;0.000675)|Lung NSC(181;0.207)		STAD - Stomach adenocarcinoma(171;0.000244)		Salmon Calcitonin(DB00017)	TGTGGGATTCCGCCTCATGGG	0.478000													12	23					0	0	1	0	0
STK10	6793	broad.mit.edu	37	5	171509417	171509417	+	Silent	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr5:171509417G>A	ENST00000176763.5	-	12	2245	c.1902C>T	c.(1900-1902)cgC>cgT	p.R634R		NM_005990.3	NP_005981.3	O94804	STK10_HUMAN	serine/threonine kinase 10	634							ATP binding|protein serine/threonine kinase activity			breast(2)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(8)|lung(15)|ovary(6)|pancreas(1)|prostate(1)|testis(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	47	Renal(175;0.000159)|Lung NSC(126;0.0056)|all_lung(126;0.0094)	Medulloblastoma(196;0.00868)|all_neural(177;0.026)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CCTCCCGGCGGCGCACGGCAT	0.552000													50	104					0	0	1	0	0
AFF3	3899	broad.mit.edu	37	2	100266099	100266099	+	Silent	SNP	A	A	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr2:100266099A>T	ENST00000317233.4	-	12	1408	c.1173T>A	c.(1171-1173)gcT>gcA	p.A391A	AFF3_ENST00000409579.1_Silent_p.A416A|AFF3_ENST00000409236.1_Silent_p.A391A|AFF3_ENST00000356421.2_Silent_p.A416A	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	391					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						TGTCAGAGAGAGCGCGGAGAG	0.368000													19	59					0	0	1	0	0
FCRL4	83417	broad.mit.edu	37	1	157551320	157551320	+	Splice_Site	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr1:157551320C>T	ENST00000271532.1	-	7	1385		c.e7+1		FCRL4_ENST00000448509.2_Splice_Site	NM_031282.2	NP_112572.1	Q96PJ5	FCRL4_HUMAN	Fc receptor-like 4							integral to membrane|plasma membrane	receptor activity			breast(2)|central_nervous_system(2)|endometrium(1)|kidney(3)|large_intestine(5)|lung(20)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	40	all_hematologic(112;0.0378)|Hepatocellular(266;0.178)	Prostate(1639;0.245)				AGAGCACAAACCTGACTTCCT	0.597000													24	29					0	0	1	0	0
UBE2NL	389898	broad.mit.edu	37	X	142967368	142967368	+	Missense_Mutation	SNP	G	G	C			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chrX:142967368G>C	ENST00000370494.1	+	1	196	c.166G>C	c.(166-168)Gaa>Caa	p.E56Q		NM_001012989.1	NP_001013007.1	Q5JXB2	UE2NL_HUMAN	ubiquitin-conjugating enzyme E2N-like	56							acid-amino acid ligase activity			breast(1)|endometrium(1)|large_intestine(8)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	24	Acute lymphoblastic leukemia(192;6.56e-05)					TTTTAAACGTGAACTATTACT	0.408000													49	79					0	0	1	0	0
FLT1	2321	broad.mit.edu	37	13	28896990	28896990	+	Missense_Mutation	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr13:28896990C>T	ENST00000282397.4	-	21	3141	c.2890G>A	c.(2890-2892)Gaa>Aaa	p.E964K	FLT1_ENST00000540678.1_Missense_Mutation_p.E182K	NM_002019.4	NP_002010.2	P17948	VGFR1_HUMAN	fms-related tyrosine kinase 1	964	Protein kinase.				cell differentiation|female pregnancy|positive regulation of vascular endothelial growth factor receptor signaling pathway	extracellular space|Golgi apparatus|integral to plasma membrane|nucleus	ATP binding|growth factor binding|vascular endothelial growth factor receptor activity			NS(1)|breast(2)|central_nervous_system(5)|endometrium(8)|kidney(3)|large_intestine(20)|lung(55)|ovary(3)|prostate(1)|skin(12)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	115	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0262)|Breast(139;0.188)	Colorectal(13;0.000674)	all cancers(112;0.0301)|Epithelial(112;0.155)|GBM - Glioblastoma multiforme(144;0.184)|OV - Ovarian serous cystadenocarcinoma(117;0.205)|Lung(94;0.207)	Sunitinib(DB01268)	GCAAAGCTTTCGCTGCTGGTG	0.478000													40	75					0	0	1	0	0
PHOSPHO2	493911	broad.mit.edu	37	2	170557640	170557640	+	Silent	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr2:170557640G>A	ENST00000359744.3	+	4	547	c.159G>A	c.(157-159)aaG>aaA	p.K53K	KLHL23_ENST00000602521.1_Intron|KLHL23_ENST00000272797.4_Intron	NM_001008489.3|NM_001199285.1|NM_001199286.1|NM_001199288.1	NP_001008489.1|NP_001186214.1|NP_001186215.1|NP_001186217.1	Q8TCD6	PHOP2_HUMAN	phosphatase, orphan 2	53							metal ion binding|pyridoxal phosphatase activity			breast(1)|large_intestine(1)|lung(6)|skin(2)	10						GAGTCTTTAAGTATTTGGGAG	0.383000													30	32					0	0	1	0	0
HERPUD2	64224	broad.mit.edu	37	7	35674870	35674870	+	Missense_Mutation	SNP	G	G	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr7:35674870G>T	ENST00000396081.1	-	6	1620	c.816C>A	c.(814-816)ttC>ttA	p.F272L	HERPUD2_ENST00000311350.3_Missense_Mutation_p.F272L|HERPUD2_ENST00000426180.1_5'UTR	NM_022373.4	NP_071768.3	Q9BSE4	HERP2_HUMAN	HERPUD family member 2	272					response to unfolded protein	integral to membrane				kidney(3)|large_intestine(5)|lung(6)|ovary(3)|prostate(1)	18						AGTCTCGATTGAAGTCTTCTT	0.438000													37	46					3.62531e-18	3.85393e-18	1	1	0
REG3G	130120	broad.mit.edu	37	2	79254978	79254978	+	Missense_Mutation	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr2:79254978G>A	ENST00000272324.5	+	5	563	c.379G>A	c.(379-381)Gtg>Atg	p.V127M	REG3G_ENST00000409471.1_Missense_Mutation_p.V81M|REG3G_ENST00000393897.2_Missense_Mutation_p.V127M	NM_001008387.2	NP_001008388.1	Q6UW15	REG3G_HUMAN	regenerating islet-derived 3 gamma	127	C-type lectin.				acute-phase response	extracellular region	sugar binding			NS(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(3)|lung(27)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						TAGCACTGATGTGATGAATTA	0.498000													47	73					0	0	1	0	0
MPRIP	23164	broad.mit.edu	37	17	17078626	17078626	+	Missense_Mutation	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr17:17078626C>T	ENST00000395811.5	+	19	2698	c.2609C>T	c.(2608-2610)gCt>gTt	p.A870V	MPRIP_ENST00000395804.3_Missense_Mutation_p.A870V|MPRIP_ENST00000341712.4_Missense_Mutation_p.A870V|MPRIP_ENST00000444976.1_Missense_Mutation_p.A832V|RP11-45M22.3_ENST00000584203.1_RNA	NM_015134.3|NM_201274.3	NP_055949.2|NP_958431.2	Q6WCQ1	MPRIP_HUMAN	myosin phosphatase Rho interacting protein	870	Interaction with PPP1R12A.					cytoplasm|cytoskeleton	actin binding			biliary_tract(1)|breast(1)|endometrium(4)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	31						AACCGCCTGGCTGCAGAGATC	0.622000													7	46					0	0	1	0	0
KIAA1324L	222223	broad.mit.edu	37	7	86542401	86542401	+	Silent	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr7:86542401C>T	ENST00000450689.2	-	14	2036	c.1851G>A	c.(1849-1851)tcG>tcA	p.S617S	KIAA1324L_ENST00000297222.6_Silent_p.S377S|KIAA1324L_ENST00000490995.1_5'UTR|KIAA1324L_ENST00000444627.1_Intron|KIAA1324L_ENST00000416314.1_Silent_p.S450S	NM_001142749.2	NP_001136221.1	A8MWY0	K132L_HUMAN	KIAA1324-like	617						integral to membrane		p.S377S(1)		breast(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(14)|ovary(6)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)	44	Esophageal squamous(14;0.0058)					AGGGGACACACGATGAACCCG	0.522000													14	25					0	0	1	0	0
RP1L1	94137	broad.mit.edu	37	8	10467031	10467031	+	Missense_Mutation	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr8:10467031G>A	ENST00000382483.3	-	4	4800	c.4577C>T	c.(4576-4578)aCg>aTg	p.T1526M		NM_178857.5	NP_849188.4	A6NKC6	A6NKC6_HUMAN	retinitis pigmentosa 1-like 1	1526					intracellular signal transduction					breast(5)|central_nervous_system(2)|cervix(2)|endometrium(6)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(16)|lung(82)|ovary(8)|prostate(5)|skin(6)|upper_aerodigestive_tract(4)|urinary_tract(3)	148				COAD - Colon adenocarcinoma(149;0.0811)		GGCCTTCTCCGTCTTCTTCAG	0.662000													29	42					0	0	1	0	0
AXL	558	broad.mit.edu	37	19	41743930	41743930	+	Missense_Mutation	SNP	G	G	A	rs141302305		TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr19:41743930G>A	ENST00000301178.4	+	7	1055	c.865G>A	c.(865-867)Gtg>Atg	p.V289M	AXL_ENST00000359092.3_Missense_Mutation_p.V289M|AXL_ENST00000593513.1_Missense_Mutation_p.V21M	NM_001278599.1|NM_021913.3	NP_001265528.1|NP_068713.2	P30530	UFO_HUMAN	AXL receptor tyrosine kinase	289	Fibronectin type-III 1.					integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity	p.V289M(2)		breast(3)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(9)|lung(12)|ovary(3)|pancreas(1)|prostate(4)|skin(3)|stomach(3)|upper_aerodigestive_tract(1)	48						GCAAGCATCCGTGCCCCCCCA	0.647000													43	67					0	0	1	0	0
CIC	23152	broad.mit.edu	37	19	42794634	42794634	+	Missense_Mutation	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr19:42794634C>T	ENST00000572681.2	+	11	4509	c.4441C>T	c.(4441-4443)Cgg>Tgg	p.R1481W	CIC_ENST00000160740.3_Missense_Mutation_p.R572W|CIC_ENST00000575354.2_Missense_Mutation_p.R572W			Q96RK0	CIC_HUMAN	capicua transcriptional repressor	572					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding			autonomic_ganglia(1)|breast(5)|central_nervous_system(32)|endometrium(10)|kidney(2)|large_intestine(7)|lung(9)|ovary(7)|prostate(3)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(2)	82		Prostate(69;0.00682)				GGGCCCCCTACGGCCCCCACC	0.672000			"""Mis, F, S"""		oligodendroglioma								35	50					0	0	1	0	0
SLC16A2	6567	broad.mit.edu	37	X	73744511	73744511	+	Missense_Mutation	SNP	C	C	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chrX:73744511C>A	ENST00000276033.5	+	3	1281	c.1115C>A	c.(1114-1116)aCc>aAc	p.T372N	SLC16A2_ENST00000587091.1_Missense_Mutation_p.T298N			P36021	MOT8_HUMAN	solute carrier family 16, member 2 (thyroid hormone transporter)	298						integral to plasma membrane|membrane fraction	monocarboxylic acid transmembrane transporter activity|symporter activity			breast(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(4)|ovary(1)|skin(2)	21					Pyruvic acid(DB00119)	GGTGTCCGCACCCTGCACCAG	0.572000													39	47					2.91434e-09	3.04329e-09	1	1	0
FBXW7	0	broad.mit.edu	37	4	153247366	153247366	+	Missense_Mutation	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr4:153247366C>T	ENST00000281708.4	-	10	2665	c.1436G>A	c.(1435-1437)cGa>cAa	p.R479Q	FBXW7_ENST00000603548.1_Missense_Mutation_p.R479Q|FBXW7_ENST00000263981.5_Missense_Mutation_p.R399Q|FBXW7_ENST00000296555.5_Missense_Mutation_p.R361Q|FBXW7_ENST00000603841.1_Missense_Mutation_p.R479Q|FBXW7_ENST00000393956.3_Missense_Mutation_p.R303Q	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	479					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding	p.R479Q(29)|p.R479L(5)|p.R399Q(3)|p.R479P(2)|p.R240L(1)|p.R361P(1)|p.R399P(1)|p.?(1)|p.R361Q(1)|p.R399L(1)|p.R240Q(1)|p.R240P(1)		NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				AGTGGCATCTCGAGAACCGCT	0.403000			"""Mis, N, D, F"""		"""colorectal, endometrial, T-ALL"""								21	27					0	0	1	0	0
FMN2	56776	broad.mit.edu	37	1	240371620	240371620	+	Missense_Mutation	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr1:240371620G>A	ENST00000319653.9	+	5	3738	c.3508G>A	c.(3508-3510)Gga>Aga	p.G1170R		NM_020066.4	NP_064450.3	Q9NZ56	FMN2_HUMAN	formin 2	1170	FH1.|Pro-rich.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			NS(1)|breast(7)|central_nervous_system(6)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(1)|kidney(10)|large_intestine(13)|lung(87)|ovary(6)|pancreas(3)|prostate(12)|skin(7)|stomach(2)|upper_aerodigestive_tract(6)|urinary_tract(2)	178	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CCCTCTACCCGGAGCGGGCAT	0.692000													6	15					0	0	1	0	0
GSTA3	2940	broad.mit.edu	37	6	52762720	52762720	+	Missense_Mutation	SNP	C	C	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr6:52762720C>A	ENST00000211122.3	-	6	514	c.449G>T	c.(448-450)gGc>gTc	p.G150V	GSTA3_ENST00000370968.1_Missense_Mutation_p.G100V	NM_000847.4	NP_000838.3	Q16772	GSTA3_HUMAN	glutathione S-transferase alpha 3	150	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			cervix(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(2)	10	Lung NSC(77;0.0912)				Glutathione(DB00143)	CAGCTTGTTGCCAACAAGGTA	0.517000													58	66					1.13205e-32	1.21438e-32	1	1	0
SPTA1	6708	broad.mit.edu	37	1	158618428	158618428	+	Silent	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr1:158618428C>T	ENST00000368148.3	-	26	3765	c.3585G>A	c.(3583-3585)acG>acA	p.T1195T	SPTA1_ENST00000368147.3_Silent_p.T1195T	NM_003126.2	NP_003117.2	P02549	SPTA1_HUMAN	spectrin, alpha, erythrocytic 1 (elliptocytosis 2)	1195					actin filament capping|actin filament organization|axon guidance|regulation of cell shape	cytosol|intrinsic to internal side of plasma membrane|spectrin|spectrin-associated cytoskeleton	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			NS(3)|breast(7)|cervix(1)|endometrium(22)|kidney(9)|large_intestine(29)|liver(2)|lung(183)|ovary(5)|prostate(18)|skin(11)|soft_tissue(1)|stomach(1)|upper_aerodigestive_tract(9)|urinary_tract(6)	307	all_hematologic(112;0.0378)					TCTGCTCCTTCGTGTCATCTG	0.498000													37	39					0	0	1	0	0
OCEL1	79629	broad.mit.edu	37	19	17338751	17338751	+	Silent	SNP	T	T	C			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr19:17338751T>C	ENST00000215061.4	+	4	599	c.555T>C	c.(553-555)tgT>tgC	p.C185C	OCEL1_ENST00000601576.1_3'UTR|OCEL1_ENST00000597836.1_Silent_p.C129C|OCEL1_ENST00000601529.1_Intron	NM_024578.1	NP_078854.1	Q9H607	OCEL1_HUMAN	occludin/ELL domain containing 1	185										central_nervous_system(2)|endometrium(2)|kidney(1)|lung(2)	7						AGGTGGGGTGTGCACAGGCAA	0.637000													25	46					0	0	1	0	0
ALS2CL	259173	broad.mit.edu	37	3	46713390	46713390	+	Missense_Mutation	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr3:46713390C>T	ENST00000318962.4	-	24	2751	c.2668G>A	c.(2668-2670)Gtg>Atg	p.V890M	ALS2CL_ENST00000415953.1_Missense_Mutation_p.V890M|ALS2CL_ENST00000383742.3_Missense_Mutation_p.V237M	NM_147129.3	NP_667340.2	Q60I27	AL2CL_HUMAN	ALS2 C-terminal like	890	VPS9.				endosome organization|regulation of Rho protein signal transduction		GTPase activator activity|identical protein binding|Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(2)|central_nervous_system(3)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(1)|lung(7)|skin(3)|stomach(2)	29				BRCA - Breast invasive adenocarcinoma(193;0.000726)|KIRC - Kidney renal clear cell carcinoma(197;0.0171)|Kidney(197;0.0202)		CGCGACACCACGTAGATGAGA	0.627000													15	24					0	0	1	0	0
FBXO24	26261	broad.mit.edu	37	7	100187923	100187923	+	Missense_Mutation	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr7:100187923C>T	ENST00000241071.6	+	3	587	c.265C>T	c.(265-267)Cgc>Tgc	p.R89C	FBXO24_ENST00000498195.1_3'UTR|FBXO24_ENST00000427939.2_Missense_Mutation_p.R127C|FBXO24_ENST00000468962.1_Missense_Mutation_p.R77C|FBXO24_ENST00000465843.1_Missense_Mutation_p.R89C|FBXO24_ENST00000360609.2_Missense_Mutation_p.R89C|PCOLCE-AS1_ENST00000442166.2_RNA	NM_033506.2	NP_277041.1	O75426	FBX24_HUMAN	F-box protein 24	89						ubiquitin ligase complex	ubiquitin-protein ligase activity			NS(2)|breast(2)|cervix(1)|endometrium(5)|kidney(1)|large_intestine(5)|lung(3)|ovary(3)|skin(4)|urinary_tract(2)	28	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					ACTCAGTCCGCGCCTCCAAGA	0.602000													22	22					0	0	1	0	0
PLXNB2	23654	broad.mit.edu	37	22	50728775	50728775	+	Missense_Mutation	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr22:50728775G>A	ENST00000449103.1	-	3	379	c.239C>T	c.(238-240)cCg>cTg	p.P80L	PLXNB2_ENST00000359337.4_Missense_Mutation_p.P80L			O15031	PLXB2_HUMAN	plexin B2	80	Sema.				regulation of small GTPase mediated signal transduction	integral to membrane|intracellular	GTPase activator activity|protein binding|receptor activity	p.P123L(1)		breast(2)|central_nervous_system(4)|cervix(2)|endometrium(11)|kidney(4)|large_intestine(3)|liver(1)|lung(20)|ovary(5)|prostate(6)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(2)	66		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.205)|LUAD - Lung adenocarcinoma(64;0.247)		CTCGATGGGCGGCGTGCACTT	0.652000													20	6					0	0	1	0	0
TBC1D1	23216	broad.mit.edu	37	4	38138875	38138875	+	Silent	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr4:38138875G>A	ENST00000261439.4	+	20	3781	c.3426G>A	c.(3424-3426)acG>acA	p.T1142T	TBC1D1_ENST00000407365.1_3'UTR|TBC1D1_ENST00000508802.1_Silent_p.T1133T	NM_001253914.1|NM_001253915.1|NM_015173.3	NP_001240843.1|NP_001240844.1|NP_055988.2	Q86TI0	TBCD1_HUMAN	TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1	1142						nucleus	Rab GTPase activator activity			NS(1)|breast(3)|kidney(1)|large_intestine(5)|lung(19)|ovary(2)|prostate(2)|skin(2)|urinary_tract(1)	36						TGCTGCAGACGGTGGAGGAGC	0.642000													29	27					0	0	1	0	0
TMEM62	80021	broad.mit.edu	37	15	43441229	43441229	+	Missense_Mutation	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr15:43441229C>T	ENST00000260403.2	+	7	1025	c.746C>T	c.(745-747)tCg>tTg	p.S249L		NM_024956.3	NP_079232.3	Q0P6H9	TMM62_HUMAN	transmembrane protein 62	249						integral to membrane				breast(1)|cervix(1)|endometrium(3)|large_intestine(3)|lung(4)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	18		all_cancers(109;1.16e-10)|all_epithelial(112;2.01e-09)|Lung NSC(122;8.91e-07)|all_lung(180;8.8e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;4.23e-07)		TTGGTTAGTTCGGCTATAGCT	0.408000													27	30					0	0	1	0	0
RRAGB	10325	broad.mit.edu	37	X	55757849	55757849	+	Nonsense_Mutation	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chrX:55757849C>T	ENST00000374941.4	+	5	935	c.346C>T	c.(346-348)Cga>Tga	p.R116*	RRAGB_ENST00000474757.1_3'UTR|RRAGB_ENST00000262850.7_Nonsense_Mutation_p.R144*	NM_006064.4	NP_006055.3	Q5VZM2	RRAGB_HUMAN	Ras-related GTP binding B	144					cellular protein localization|cellular response to amino acid stimulus|positive regulation of TOR signaling cascade|signal transduction	Golgi apparatus|lysosome|nucleus	GTP binding|protein binding			breast(1)|endometrium(3)|large_intestine(5)|lung(3)|pancreas(1)|prostate(1)	14						CAACATCTTCCGAAATGTGGA	0.403000													7	13					0	0	1	0	0
CD226	10666	broad.mit.edu	37	18	67563152	67563152	+	Missense_Mutation	SNP	C	C	T	rs79158855	byFrequency	TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr18:67563152C>T	ENST00000280200.4	-	4	780	c.512G>A	c.(511-513)cGt>cAt	p.R171H	CD226_ENST00000577287.1_Missense_Mutation_p.R16H|CD226_ENST00000581982.1_Missense_Mutation_p.R16H|CD226_ENST00000582621.1_Missense_Mutation_p.R171H	NM_006566.2	NP_006557.2	Q15762	CD226_HUMAN	CD226 molecule	171	Ig-like C2-type 2.				cell adhesion|cell recognition|positive regulation of Fc receptor mediated stimulatory signaling pathway|positive regulation of immunoglobulin mediated immune response|positive regulation of mast cell activation|positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	cell surface|integral to plasma membrane|membrane raft	cell adhesion molecule binding|integrin binding|protein kinase binding|receptor activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(5)|lung(14)|prostate(1)|urinary_tract(1)	24		Esophageal squamous(42;0.129)				GTCGATCTGACGGGGCTGGAT	0.512000													26	28					0	0	1	0	0
PRL	5617	broad.mit.edu	37	6	22290511	22290511	+	Silent	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr6:22290511C>T	ENST00000306482.1	-	4	902	c.384G>A	c.(382-384)acG>acA	p.T128T	RP3-404K8.2_ENST00000561912.1_RNA	NM_000948.5|NM_001163558.2	NP_000939.1|NP_001157030.1	P01236	PRL_HUMAN	prolactin	128					cell proliferation|cell surface receptor linked signaling pathway|female pregnancy|lactation|positive regulation of JAK-STAT cascade|regulation of multicellular organism growth	cytosol|extracellular region	hormone activity|prolactin receptor binding			NS(1)|endometrium(2)|large_intestine(6)|lung(6)|prostate(1)	16	Ovarian(93;0.163)					CACGTACTTCCGTGACCAGAT	0.463000													29	40					0	0	1	0	0
TAB3	257397	broad.mit.edu	37	X	30872877	30872877	+	Missense_Mutation	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chrX:30872877G>A	ENST00000378933.1	-	3	1082	c.905C>T	c.(904-906)tCa>tTa	p.S302L	TAB3_ENST00000288422.2_Missense_Mutation_p.S302L|TAB3_ENST00000378932.2_Missense_Mutation_p.S302L|TAB3_ENST00000378930.3_Missense_Mutation_p.S302L	NM_152787.3	NP_690000.2	Q8N5C8	TAB3_HUMAN	TGF-beta activated kinase 1/MAP3K7 binding protein 3	302	Pro-rich.				activation of MAPK activity|I-kappaB kinase/NF-kappaB cascade|innate immune response|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|positive regulation of NF-kappaB transcription factor activity|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|endosome membrane|plasma membrane	protein binding|zinc ion binding			NS(1)|breast(1)|endometrium(8)|kidney(1)|large_intestine(6)|lung(6)|ovary(2)|pancreas(1)|skin(1)	27						GCTGAAGGGTGAAGGACATTG	0.488000													21	18					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56569658	56569658	+	Missense_Mutation	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr19:56569658C>T	ENST00000390649.3	+	14	3352	c.3352C>T	c.(3352-3354)Ctt>Ttt	p.L1118F		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	1118						mitochondrion|nucleolus	ATP binding	p.L1118I(1)		breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CTCCTTGGCCCTTTCCTGCAA	0.517000													23	32					0	0	1	0	0
SPIRE2	84501	broad.mit.edu	37	16	89922602	89922602	+	Silent	SNP	C	C	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr16:89922602C>A	ENST00000378247.3	+	7	1103	c.1060C>A	c.(1060-1062)Cgg>Agg	p.R354R	SPIRE2_ENST00000393062.2_Silent_p.R354R	NM_032451.1	NP_115827.1	Q8WWL2	SPIR2_HUMAN	spire-type actin nucleation factor 2	354	WH2 3.				transport	cytoplasm|cytoskeleton	actin binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(10)|upper_aerodigestive_tract(2)|urinary_tract(1)	21		Lung NSC(15;5.15e-06)|all_lung(18;8.38e-06)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0286)		CAAGCAGGAGCGGAGGCTGCG	0.682000													7	11					1	1	1	1	0
IGHG4	0	broad.mit.edu	37	14	106092291	106092291	+	RNA	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr14:106092291G>A	ENST00000390543.2	-	0	112																											CCACGACACCGTCACCGGTTC	0.672000													21	23					0	0	1	0	0
PLK3	1263	broad.mit.edu	37	1	45268952	45268952	+	Missense_Mutation	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr1:45268952G>A	ENST00000372201.4	+	8	1200	c.961G>A	c.(961-963)Gat>Aat	p.D321N	PLK3_ENST00000465443.1_3'UTR	NM_004073.2	NP_004064.2	Q9H4B4	PLK3_HUMAN	polo-like kinase 3	321						membrane	ATP binding|protein binding|protein serine/threonine kinase activity			endometrium(4)|large_intestine(2)|lung(8)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	Acute lymphoblastic leukemia(166;0.155)					CTACACCCCCGATCGACTCCC	0.577000													29	45					0	0	1	0	0
SLC28A3	64078	broad.mit.edu	37	9	86894919	86894919	+	Missense_Mutation	SNP	A	A	G			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr9:86894919A>G	ENST00000376238.4	-	16	1848	c.1799T>C	c.(1798-1800)gTg>gCg	p.V600A	SLC28A3_ENST00000537648.1_Missense_Mutation_p.V531A|RP11-380F14.2_ENST00000419815.1_RNA	NM_001199633.1|NM_022127.2	NP_001186562.1|NP_071410.1	Q9HAS3	S28A3_HUMAN	solute carrier family 28 (concentrative nucleoside transporter), member 3	600					nucleobase, nucleoside and nucleotide metabolic process	integral to membrane|plasma membrane	nucleoside binding			endometrium(2)|large_intestine(6)|lung(17)|ovary(1)|pancreas(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	31						GAAGCAGGCCACGGTCCCCGC	0.587000													11	23					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178952085	178952085	+	Missense_Mutation	SNP	A	A	G	rs121913279		TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr3:178952085A>G	ENST00000263967.3	+	21	3297	c.3140A>G	c.(3139-3141)cAt>cGt	p.H1047R		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	1047	PI3K/PI4K.		H -> L (in cancer).|H -> R (in KERSEB; shows an increase in lipid kinase activity; oncogenic in vivo; requires binding to p85 regulatory subunit to induce cellular transformation but not interaction with RAS; may mimic the conformatitonal change triggered by the interaction with RAS; enhances invadopodia-mediated extracellular matrix degradation and invasion in breast cancer cells; increases lipid kinase activity; may alter the interaction of the PI3K/ PI4K kinase domain with the cell membrane).|H -> Y (in cancer).		epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.H1047R(1387)|p.H1047L(194)|p.H1047P(1)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			AATGATGCACATCATGGTGGC	0.378000	H1047L(EFM19_BREAST)|H1047R(BT20_BREAST)|H1047R(CAL29_URINARY_TRACT)|H1047R(CAL33_UPPER_AERODIGESTIVE_TRACT)|H1047R(DETROIT562_UPPER_AERODIGESTIVE_TRACT)|H1047R(HCC1954_BREAST)|H1047R(HCT116_LARGE_INTESTINE)|H1047R(HSC2_UPPER_AERODIGESTIVE_TRACT)|H1047R(LS180_LARGE_INTESTINE)|H1047R(MCAS_OVARY)|H1047R(MDAMB453_BREAST)|H1047R(NCIH1048_LUNG)|H1047R(RKO_LARGE_INTESTINE)|H1047R(SKOV3_OVARY)|H1047R(T47D_BREAST)	57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			44	9					0	0	1	0	0
SUV39H1	6839	broad.mit.edu	37	X	48558921	48558921	+	Missense_Mutation	SNP	A	A	C			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chrX:48558921A>C	ENST00000376687.3	+	3	795	c.605A>C	c.(604-606)aAg>aCg	p.K202T	SUV39H1_ENST00000337852.6_Missense_Mutation_p.K213T|SUV39H1_ENST00000453214.2_Intron|AF196970.3_ENST00000416061.1_RNA	NM_003173.2	NP_003164.1	O43463	SUV91_HUMAN	suppressor of variegation 3-9 homolog 1 (Drosophila)	202	Pre-SET.				cell cycle|cell differentiation|chromatin silencing at rDNA|interspecies interaction between organisms|rRNA processing|transcription, DNA-dependent	chromatin silencing complex|chromosome, centromeric region|condensed nuclear chromosome|rDNA heterochromatin	chromatin binding|histone methyltransferase activity (H3-K9 specific)|protein N-terminus binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(4)|lung(5)|prostate(1)|upper_aerodigestive_tract(1)	14						TCACTGCACAAGTTTGCCTAC	0.652000													22	46					0	0	1	0	0
ADAM12	8038	broad.mit.edu	37	10	127724804	127724804	+	Nonsense_Mutation	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr10:127724804G>A	ENST00000368679.4	-	21	2758	c.2449C>T	c.(2449-2451)Cga>Tga	p.R817*		NM_003474.4	NP_003465.3	O43184	ADA12_HUMAN	ADAM metallopeptidase domain 12	817					cell adhesion|epidermal growth factor receptor signaling pathway|myoblast fusion|proteolysis	extracellular region|integral to membrane|plasma membrane	metalloendopeptidase activity|protein binding|SH3 domain binding|zinc ion binding	p.R817*(2)		biliary_tract(1)|breast(7)|central_nervous_system(4)|endometrium(5)|kidney(3)|large_intestine(11)|liver(1)|lung(24)|ovary(2)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	69		all_epithelial(44;7.06e-05)|all_lung(145;0.00563)|Lung NSC(174;0.00834)|Colorectal(57;0.102)|all_neural(114;0.107)|Breast(234;0.22)		COAD - Colon adenocarcinoma(40;0.141)|Colorectal(40;0.216)		GGAAGCACTCGCTGAGTTGAC	0.597000													31	44					0	0	1	0	0
FGD6	55785	broad.mit.edu	37	12	95531317	95531317	+	Missense_Mutation	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr12:95531317G>A	ENST00000343958.4	-	7	3198	c.2975C>T	c.(2974-2976)gCt>gTt	p.A992V	FGD6_ENST00000546711.1_Missense_Mutation_p.A992V|FGD6_ENST00000549499.1_Missense_Mutation_p.A992V	NM_018351.3	NP_060821.3	Q6ZV73	FGD6_HUMAN	FYVE, RhoGEF and PH domain containing 6	992	DH.			A -> T (in Ref. 2; AAH13319).	actin cytoskeleton organization|filopodium assembly|regulation of Cdc42 GTPase activity|regulation of cell shape	cytoskeleton|Golgi apparatus|lamellipodium|ruffle	metal ion binding|Rho guanyl-nucleotide exchange factor activity|small GTPase binding			breast(3)|cervix(1)|endometrium(6)|kidney(3)|large_intestine(14)|liver(1)|lung(12)|ovary(3)|prostate(3)|skin(6)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	56						TCTAACAACAGCAGCAAAACC	0.328000													21	33					0	0	1	0	0
NRG1	3084	broad.mit.edu	37	8	32505335	32505335	+	Silent	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr8:32505335G>A	ENST00000520502.2	+	1	99	c.99G>A	c.(97-99)ccG>ccA	p.P33P	NRG1_ENST00000523079.1_Intron|NRG1_ENST00000521670.1_Intron|NRG1_ENST00000405005.2_Intron|NRG1_ENST00000520407.1_Intron|NRG1_ENST00000287845.5_Intron|NRG1_ENST00000287840.5_Intron|NRG1_ENST00000356819.4_Intron|NRG1_ENST00000519301.1_Intron|NRG1_ENST00000287842.3_Intron|NRG1_ENST00000338921.4_Intron|NRG1_ENST00000341377.5_Intron	NM_013959.3	NP_039253.1	Q02297	NRG1_HUMAN	neuregulin 1	0					activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|cardiac muscle cell differentiation|cell communication|cell proliferation|cellular protein complex disassembly|embryo development|mammary gland development|negative regulation of cardiac muscle cell apoptosis|negative regulation of secretion|negative regulation of transcription, DNA-dependent|nervous system development|neural crest cell development|Notch signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell adhesion|positive regulation of cell growth|positive regulation of striated muscle cell differentiation|regulation of protein heterodimerization activity|regulation of protein homodimerization activity|transmembrane receptor protein tyrosine kinase signaling pathway|ventricular cardiac muscle cell differentiation|wound healing	apical plasma membrane|extracellular region|extracellular space|integral to membrane|nucleus|plasma membrane	cytokine activity|ErbB-3 class receptor binding|growth factor activity|protein binding|protein tyrosine kinase activator activity|receptor tyrosine kinase binding|transcription cofactor activity|transmembrane receptor protein tyrosine kinase activator activity			endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(12)|lung(18)|ovary(1)|prostate(1)|skin(1)	39		Breast(100;0.203)		KIRC - Kidney renal clear cell carcinoma(67;0.0768)|Kidney(114;0.0943)		ATGGGCTTCCGGCAGCAGAAG	0.622000													18	34					0	0	1	0	0
OR52I2	143502	broad.mit.edu	37	11	4608812	4608812	+	Missense_Mutation	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr11:4608812G>A	ENST00000312614.4	+	1	792	c.770G>A	c.(769-771)gGt>gAt	p.G257D		NM_001005170.2	NP_001005170.1	Q8NH67	O52I2_HUMAN	olfactory receptor, family 52, subfamily I, member 2	257					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			endometrium(3)|kidney(1)|large_intestine(2)|lung(11)|pancreas(1)|skin(1)	19		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		GCAGTATTTGGTCTCTCCTCA	0.473000													42	69					0	0	1	0	0
C2orf54	79919	broad.mit.edu	37	2	241829466	241829466	+	Missense_Mutation	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr2:241829466G>A	ENST00000307486.8	-	3	501	c.403C>T	c.(403-405)Cgt>Tgt	p.R135C	C2orf54_ENST00000402775.2_Missense_Mutation_p.R116C|C2orf54_ENST00000388934.4_Missense_Mutation_p.R284C			Q08AI8	CB054_HUMAN	chromosome 2 open reading frame 54	284										haematopoietic_and_lymphoid_tissue(1)|lung(4)|prostate(1)	6		all_epithelial(40;3.99e-16)|Breast(86;2.35e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0294)|Lung NSC(271;0.094)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;8.14e-32)|all cancers(36;4.77e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.38e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;4.88e-06)|Lung(119;0.000452)|LUSC - Lung squamous cell carcinoma(224;0.00415)|Colorectal(34;0.021)|COAD - Colon adenocarcinoma(134;0.15)		CCACTGTCACGCCAGCTCTCG	0.662000													20	37					0	0	1	0	0
PLEKHS1	79949	broad.mit.edu	37	10	115540379	115540379	+	Missense_Mutation	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr10:115540379G>A	ENST00000354462.3	+	6	594	c.436G>A	c.(436-438)Ggc>Agc	p.G146S	PLEKHS1_ENST00000369312.4_Missense_Mutation_p.G314S|PLEKHS1_ENST00000369309.1_Missense_Mutation_p.G230S|PLEKHS1_ENST00000361048.1_3'UTR					pleckstrin homology domain containing, family S member 1																		GCTTACCATCGGCAGGATCCC	0.403000													20	33					0	0	1	0	0
PDGFRB	5159	broad.mit.edu	37	5	149497300	149497300	+	Silent	SNP	G	G	A	rs2229559		TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr5:149497300G>A	ENST00000261799.4	-	22	3487	c.3018C>T	c.(3016-3018)tcC>tcT	p.S1006S		NM_002609.3	NP_002600.1	P09619	PGFRB_HUMAN	platelet-derived growth factor receptor, beta polypeptide	1006					aorta morphogenesis|cardiac myofibril assembly|hemopoiesis|metanephric glomerular capillary formation|metanephric glomerular mesangial cell proliferation involved in metanephros development|peptidyl-tyrosine phosphorylation|positive regulation of calcium ion import|positive regulation of chemotaxis|positive regulation of DNA biosynthetic process|positive regulation of ERK1 and ERK2 cascade|positive regulation of MAP kinase activity|positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway|positive regulation of mitosis|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of reactive oxygen species metabolic process|positive regulation of smooth muscle cell migration|positive regulation of smooth muscle cell proliferation|protein autophosphorylation|regulation of actin cytoskeleton organization|retina vasculature development in camera-type eye|smooth muscle cell chemotaxis	apical plasma membrane|cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet activating factor receptor activity|platelet-derived growth factor beta-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|vascular endothelial growth factor receptor activity			breast(3)|central_nervous_system(5)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(9)|kidney(3)|large_intestine(12)|lung(20)|ovary(3)|prostate(3)|skin(3)|stomach(6)|urinary_tract(1)	75		all_hematologic(541;0.224)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)		Becaplermin(DB00102)|Dasatinib(DB01254)|Imatinib(DB00619)|Sorafenib(DB00398)|Sunitinib(DB01268)	TATAGAGGACGGAGCTGGTGT	0.617000			T	"""ETV6, TRIP11, HIP1, RAB5EP, H4, NIN, HCMOGT-1, PDE4DIP"""	"""MPD, AML, CMML, CML"""								24	47					0	0	1	0	0
PPP2R1A	5518	broad.mit.edu	37	19	52716212	52716212	+	Missense_Mutation	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr19:52716212C>T	ENST00000322088.6	+	6	714	c.656C>T	c.(655-657)tCg>tTg	p.S219L	PPP2R1A_ENST00000444322.2_Missense_Mutation_p.S164L|PPP2R1A_ENST00000462990.1_Missense_Mutation_p.S40L	NM_014225.5	NP_055040.2	P30153	2AAA_HUMAN	protein phosphatase 2, regulatory subunit A, alpha	219	PP2A subunit B binding.|Polyoma small and medium T antigens Binding.|SV40 small T antigen binding.				ceramide metabolic process|chromosome segregation|G2/M transition of mitotic cell cycle|inactivation of MAPK activity|induction of apoptosis|negative regulation of cell growth|negative regulation of tyrosine phosphorylation of Stat3 protein|protein complex assembly|protein dephosphorylation|regulation of cell adhesion|regulation of cell differentiation|regulation of DNA replication|regulation of transcription, DNA-dependent|regulation of Wnt receptor signaling pathway|response to organic substance|RNA splicing|second-messenger-mediated signaling	chromosome, centromeric region|cytosol|membrane|microtubule cytoskeleton|mitochondrion|nucleus|protein phosphatase type 2A complex|soluble fraction	antigen binding|protein heterodimerization activity|protein phosphatase type 2A regulator activity			NS(1)|breast(4)|cervix(2)|endometrium(62)|kidney(1)|large_intestine(7)|lung(21)|ovary(32)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	135				GBM - Glioblastoma multiforme(134;0.00456)|OV - Ovarian serous cystadenocarcinoma(262;0.015)		CCCTAGGACTCGGTGCGGCTG	0.647000			Mis		clear cell ovarian carcinoma								22	22					0	0	1	0	0
CDX2	1045	broad.mit.edu	37	13	28537414	28537414	+	Silent	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr13:28537414C>T	ENST00000381020.7	-	3	2912	c.780G>A	c.(778-780)ccG>ccA	p.P260P	CDX2_ENST00000548877.1_5'UTR	NM_001265.4	NP_001256.3	Q99626	CDX2_HUMAN	caudal type homeobox 2	260	Poly-Pro.				organ morphogenesis|transcription from RNA polymerase II promoter		sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			endometrium(2)|large_intestine(1)|lung(6)	9	all_cancers(110;0.191)|all_hematologic(3;0.0447)|Acute lymphoblastic leukemia(6;0.155)	Lung SC(185;0.0156)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	GBM - Glioblastoma multiforme(144;0.0407)|all cancers(112;0.0491)|OV - Ovarian serous cystadenocarcinoma(117;0.199)		GCGGCGGAGGCGGCTGTGGTG	0.567000			T	ETV6	AML								25	23					0	0	1	0	0
SMOC1	64093	broad.mit.edu	37	14	70346406	70346406	+	Missense_Mutation	SNP	C	C	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr14:70346406C>A	ENST00000381280.4	+	1	264	c.11C>A	c.(10-12)gCg>gAg	p.A4E	SMOC1_ENST00000555917.1_Intron|SMOC1_ENST00000361956.3_Missense_Mutation_p.A4E	NM_001034852.2|NM_022137.5	NP_001030024.1|NP_071420.1	Q9H4F8	SMOC1_HUMAN	SPARC related modular calcium binding 1	4					cell differentiation|eye development|limb development|regulation of osteoblast differentiation|signal transduction	basement membrane	calcium ion binding			breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	21				all cancers(60;0.00417)|BRCA - Breast invasive adenocarcinoma(234;0.0119)|OV - Ovarian serous cystadenocarcinoma(108;0.028)		ATGCTGCCCGCGCGCTGCGCC	0.751000													6	3					3.59834e-05	3.66038e-05	1	1	0
MAGEB6	158809	broad.mit.edu	37	X	26212339	26212339	+	Missense_Mutation	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chrX:26212339G>A	ENST00000379034.1	+	2	525	c.376G>A	c.(376-378)Gtg>Atg	p.V126M		NM_173523.2	NP_775794.2	Q8N7X4	MAGB6_HUMAN	melanoma antigen family B, 6	126	Ser-rich.									breast(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(18)|ovary(3)|prostate(2)	33						AAAATATGATGTGGCTGCCAA	0.557000													48	71					0	0	1	0	0
PCDHA2	0	broad.mit.edu	37	5	140176114	140176114	+	Missense_Mutation	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr5:140176114C>T	ENST00000526136.1	+	1	1565	c.1565C>T	c.(1564-1566)cCg>cTg	p.P522L	PCDHA1_ENST00000394633.3_Intron|PCDHA2_ENST00000520672.2_Missense_Mutation_p.P522L|PCDHA2_ENST00000378132.1_Missense_Mutation_p.P522L|PCDHA1_ENST00000504120.2_Intron	NM_018905.2	NP_061728.1														NS(1)|breast(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(16)|lung(26)|ovary(4)|prostate(6)|skin(2)|upper_aerodigestive_tract(1)	71			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GCGCTGCAGCCGCTGGACCAC	0.687000													149	114					0	0	1	0	0
ZFHX4	79776	broad.mit.edu	37	8	77766792	77766792	+	Silent	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr8:77766792G>A	ENST00000521891.2	+	10	8083	c.7635G>A	c.(7633-7635)ccG>ccA	p.P2545P	ZFHX4_ENST00000050961.6_Silent_p.P2500P|ZFHX4_ENST00000455469.2_Silent_p.P2500P|ZFHX4_ENST00000518282.1_Silent_p.P2519P	NM_024721.4	NP_078997.4	Q86UP3	ZFHX4_HUMAN	zinc finger homeobox 4	2500						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.P2529P(1)		NS(3)|breast(11)|central_nervous_system(1)|endometrium(36)|haematopoietic_and_lymphoid_tissue(2)|kidney(15)|large_intestine(66)|liver(2)|lung(245)|ovary(11)|pancreas(3)|prostate(11)|skin(7)|upper_aerodigestive_tract(13)|urinary_tract(6)	432			BRCA - Breast invasive adenocarcinoma(89;0.0895)			CCAACAATCCGCTGATGACTG	0.537000										HNSCC(33;0.089)			46	84					0	0	1	0	0
ARHGEF25	115557	broad.mit.edu	37	12	58009072	58009072	+	Missense_Mutation	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr12:58009072C>T	ENST00000286494.4	+	11	1473	c.1013C>T	c.(1012-1014)aCg>aTg	p.T338M	AC025165.8_ENST00000444467.1_RNA|ARHGEF25_ENST00000333972.7_Missense_Mutation_p.T377M|AC025165.8_ENST00000356672.3_RNA|AC025165.8_ENST00000593846.1_RNA	NM_182947.3	NP_891992.2	Q86VW2	ARHGP_HUMAN	Rho guanine nucleotide exchange factor (GEF) 25	338					regulation of Rho protein signal transduction	cytosol|plasma membrane|sarcomere	Rho guanyl-nucleotide exchange factor activity			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(7)|lung(10)|pancreas(1)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	28						GATATGATGACGCTGGGGAGA	0.562000													16	33					0	0	1	0	0
CTC-340A15.2	0	broad.mit.edu	37	5	164028103	164028103	+	RNA	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr5:164028103C>T	ENST00000486913.3	+	0	281				CTC-340A15.2_ENST00000522646.1_RNA|CTC-340A15.2_ENST00000522303.1_RNA|CTC-340A15.2_ENST00000519570.1_RNA|CTC-340A15.2_ENST00000517508.1_RNA|CTC-340A15.2_ENST00000523704.1_RNA																							TCGCCCAGGTCGTGGCCGATC	0.597000													4	9					0	0	1	0	0
SLC35A2	7355	broad.mit.edu	37	X	48762195	48762195	+	Missense_Mutation	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chrX:48762195C>T	ENST00000376521.1	-	4	1312	c.991G>A	c.(991-993)Gtc>Atc	p.V331I	SLC35A2_ENST00000413561.2_Missense_Mutation_p.V270I|SLC35A2_ENST00000247138.5_Missense_Mutation_p.V331I|SLC35A2_ENST00000452555.2_Missense_Mutation_p.V359I|SLC35A2_ENST00000376515.3_Intron|SLC35A2_ENST00000445167.2_Intron|SLC35A2_ENST00000376529.3_Intron	NM_001042498.2	NP_001035963.1	P78381	S35A2_HUMAN	solute carrier family 35 (UDP-galactose transporter), member A2	331					galactose metabolic process	Golgi membrane|integral to membrane|nucleus	sugar:hydrogen symporter activity|UDP-galactose transmembrane transporter activity			breast(1)|endometrium(4)|kidney(2)|large_intestine(1)|lung(5)|upper_aerodigestive_tract(2)	15						GCACCAATGACGAGTCCAGCG	0.612000													10	20					0	0	1	0	0
STK16	8576	broad.mit.edu	37	2	220112473	220112473	+	Missense_Mutation	SNP	T	T	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr2:220112473T>A	ENST00000409638.3	+	6	823	c.651T>A	c.(649-651)gaT>gaA	p.D217E	STK16_ENST00000409260.1_Missense_Mutation_p.D262E|STK16_ENST00000409743.1_Intron|STK16_ENST00000396738.2_Missense_Mutation_p.D217E|STK16_ENST00000409516.3_Missense_Mutation_p.D99E	NM_001008910.2	NP_001008910.1	O75716	STK16_HUMAN	serine/threonine kinase 16	217	Protein kinase.				protein complex assembly	membrane	ATP binding|protein binding|protein serine/threonine kinase activity			skin(1)	1		Renal(207;0.0474)		Epithelial(149;1.2e-06)|all cancers(144;0.000197)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		AGCGGACTGATGTCTGGGTGA	0.587000													5	4					0	0	1	0	0
STAT3	6774	broad.mit.edu	37	17	40481653	40481653	+	Missense_Mutation	SNP	A	A	C			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr17:40481653A>C	ENST00000264657.5	-	13	1464	c.1152T>G	c.(1150-1152)ttT>ttG	p.F384L	STAT3_ENST00000389272.3_Missense_Mutation_p.F286L|STAT3_ENST00000585517.1_Missense_Mutation_p.F384L|STAT3_ENST00000404395.3_Missense_Mutation_p.F384L|STAT3_ENST00000588969.1_Missense_Mutation_p.F384L	NM_003150.3|NM_139276.2	NP_003141.2|NP_644805.1	P40763	STAT3_HUMAN	signal transducer and activator of transcription 3 (acute-phase response factor)	384			F -> L (in AD-HIES).|F -> S (in AD-HIES).		cellular component movement|eating behavior|eye photoreceptor cell differentiation|glucose homeostasis|interleukin-6-mediated signaling pathway|interspecies interaction between organisms|JAK-STAT cascade involved in growth hormone signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein import into nucleus|response to estradiol stimulus|sexual reproduction|temperature homeostasis	cytosol|nucleus|plasma membrane	calcium ion binding|ligand-regulated transcription factor activity|protein dimerization activity|protein kinase binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		all_cancers(22;1.39e-06)|all_epithelial(22;2.95e-05)|Breast(137;0.000135)		BRCA - Breast invasive adenocarcinoma(366;0.139)		CCAGAATGTTAAATTTCCGGG	0.458000									Hyperimmunoglobulin E Recurrent Infection Syndrome				36	39					0	0	1	0	0
KCNS2	3788	broad.mit.edu	37	8	99441462	99441462	+	Missense_Mutation	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr8:99441462C>T	ENST00000287042.4	+	2	1605	c.1255C>T	c.(1255-1257)Cgc>Tgc	p.R419C	KCNS2_ENST00000521839.1_Missense_Mutation_p.R419C	NM_020697.2	NP_065748.1	Q9ULS6	KCNS2_HUMAN	potassium voltage-gated channel, delayed-rectifier, subfamily S, member 2	419						voltage-gated potassium channel complex	voltage-gated potassium channel activity	p.R419C(1)		autonomic_ganglia(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(11)|ovary(1)|prostate(1)|skin(1)|urinary_tract(2)	31	Breast(36;2.4e-06)		OV - Ovarian serous cystadenocarcinoma(57;0.0448)			CTTTTACCGGCGCCAAAAGCA	0.512000													47	101					0	0	1	0	0
DCP2	167227	broad.mit.edu	37	5	112312615	112312615	+	Translation_Start_Site	SNP	G	G	A	rs2416298		TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr5:112312615G>A	ENST00000543319.1	+	0	137				DCP2_ENST00000504961.1_3'UTR|DCP2_ENST00000515408.1_De_novo_Start_InFrame|DCP2_ENST00000389063.2_De_novo_Start_InFrame			Q8IU60	DCP2_HUMAN	decapping mRNA 2						exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|histone mRNA catabolic process|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasmic mRNA processing body|cytosol|nucleus|RNA-induced silencing complex	exoribonuclease activity, producing 5'-phosphomonoesters|manganese ion binding|protein binding|RNA binding			endometrium(3)|large_intestine(6)|lung(1)	10		all_cancers(142;4.41e-05)|all_epithelial(76;3.65e-07)|Colorectal(10;0.00115)|Prostate(80;0.00133)|Ovarian(225;0.0443)		OV - Ovarian serous cystadenocarcinoma(64;6.98e-08)|Epithelial(69;7.87e-08)|all cancers(49;1.06e-05)|COAD - Colon adenocarcinoma(37;0.0123)|Colorectal(14;0.0171)		CACTGTTCCTGCTGTGGGTCC	0.682000													52	86					0	0	1	0	0
HIST1H2AL	8332	broad.mit.edu	37	6	27833147	27833147	+	Silent	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr6:27833147C>T	ENST00000357320.2	+	1	114	c.15C>T	c.(13-15)ggC>ggT	p.G5G		NM_003511.2	NP_003502.1	P0C0S8	H2A1_HUMAN	histone cluster 1, H2al	5					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding			breast(1)|endometrium(1)|large_intestine(2)|lung(3)|urinary_tract(2)	9						CGGGACGCGGCAAGCAGGGAG	0.587000													45	76					0	0	1	0	0
CD36	948	broad.mit.edu	37	7	80290415	80290415	+	Silent	SNP	C	C	T	rs146796766		TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr7:80290415C>T	ENST00000435819.1	+	8	1002	c.318C>T	c.(316-318)gaC>gaT	p.D106D	CD36_ENST00000447544.2_Silent_p.D106D|CD36_ENST00000394788.3_Silent_p.D106D|CD36_ENST00000309881.7_Silent_p.D106D|CD36_ENST00000534394.1_Silent_p.D30D|CD36_ENST00000432207.1_Silent_p.D106D|CD36_ENST00000538969.1_Silent_p.D106D|CD36_ENST00000544133.1_Silent_p.D106D|CD36_ENST00000433696.2_Silent_p.D106D			P16671	CD36_HUMAN	CD36 molecule (thrombospondin receptor)	106	Required for interaction with thrombospondins, THBS1 and THBS2.				cell adhesion|cGMP-mediated signaling|cholesterol transport|lipid metabolic process|lipid storage|lipoprotein transport|low-density lipoprotein particle clearance|nitric oxide mediated signal transduction|plasma membrane long-chain fatty acid transport|platelet activation|platelet degranulation|positive regulation of cell-matrix adhesion|positive regulation of macrophage derived foam cell differentiation	integral to plasma membrane|membrane fraction|platelet alpha granule membrane	lipid binding|low-density lipoprotein receptor activity|thrombospondin receptor activity|transforming growth factor beta binding			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(10)|large_intestine(1)|lung(6)|ovary(1)	21						TAACCCAGGACGCTGAGGACA	0.408000													18	43					0	0	1	0	0
APOB	338	broad.mit.edu	37	2	21256329	21256329	+	Silent	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr2:21256329G>A	ENST00000233242.1	-	9	1093	c.966C>T	c.(964-966)gcC>gcT	p.A322A	APOB_ENST00000399256.4_Silent_p.A322A	NM_000384.2	NP_000375.2	P04114	APOB_HUMAN	apolipoprotein B	322	Vitellogenin.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			NS(5)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(19)|kidney(10)|large_intestine(63)|liver(5)|lung(125)|ovary(16)|pancreas(1)|prostate(5)|skin(31)|stomach(1)|upper_aerodigestive_tract(4)|urinary_tract(6)	305	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	AAACAGCTTCGGCCTGCTTTG	0.438000													39	52					0	0	1	0	0
FLNA	0	broad.mit.edu	37	X	153581007	153581007	+	Missense_Mutation	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chrX:153581007C>T	ENST00000422373.1	-	39	6640	c.6392G>A	c.(6391-6393)cGg>cAg	p.R2131Q	FLNA_ENST00000360319.4_Missense_Mutation_p.R2131Q|FLNA_ENST00000344736.4_Missense_Mutation_p.R2099Q|FLNA_ENST00000369856.3_Missense_Mutation_p.R272Q|FLNA_ENST00000369850.3_Missense_Mutation_p.R2139Q	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	2139					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					CTCTTTCACCCGGCCCTCGCC	0.617000													25	37					0	0	1	0	0
CSMD3	114788	broad.mit.edu	37	8	113254010	113254010	+	Silent	SNP	A	A	G			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr8:113254010A>G	ENST00000297405.5	-	66	10651	c.10407T>C	c.(10405-10407)ggT>ggC	p.G3469G	CSMD3_ENST00000343508.3_Silent_p.G3429G|CSMD3_ENST00000352409.3_Silent_p.G3399G|CSMD3_ENST00000455883.2_Silent_p.G3300G	NM_198123.1	NP_937756.1	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3	3469						integral to membrane|plasma membrane				breast(7)|central_nervous_system(6)|endometrium(44)|haematopoietic_and_lymphoid_tissue(8)|kidney(36)|large_intestine(72)|liver(5)|lung(389)|ovary(24)|prostate(6)|skin(23)|upper_aerodigestive_tract(19)|urinary_tract(7)	646						ATATTTTAGAACCAGCTATGA	0.388000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			26	47					0	0	1	0	0
SLC6A9	6536	broad.mit.edu	37	1	44474144	44474144	+	Silent	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr1:44474144G>A	ENST00000372310.3	-	5	636	c.471C>T	c.(469-471)gcC>gcT	p.A157A	SLC6A9_ENST00000372306.3_Silent_p.A157A|SLC6A9_ENST00000475075.2_Silent_p.A46A|SLC6A9_ENST00000372307.3_Silent_p.A92A|SLC6A9_ENST00000360584.2_Silent_p.A230A|SLC6A9_ENST00000537678.1_Silent_p.A92A|SLC6A9_ENST00000357730.2_Silent_p.A176A	NM_001024845.2	NP_001020016.1	P48067	SC6A9_HUMAN	solute carrier family 6 (neurotransmitter transporter, glycine), member 9	230						integral to plasma membrane|membrane fraction	glycine:sodium symporter activity|neurotransmitter:sodium symporter activity	p.A230A(1)|p.A157A(1)		endometrium(3)|large_intestine(8)|lung(7)|ovary(1)|skin(1)|urinary_tract(2)	22	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)			Glycine(DB00145)	CCAGTACACCGGCGCAGTCAT	0.607000													34	58					0	0	1	0	0
CD28	940	broad.mit.edu	37	2	204571286	204571286	+	Missense_Mutation	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr2:204571286G>A	ENST00000458610.2	+	1	40	c.40G>A	c.(40-42)Ggg>Agg	p.G14R	CD28_ENST00000324106.7_5'UTR|CD28_ENST00000374481.3_5'UTR			P10747	CD28_HUMAN	CD28 molecule	0					cell surface receptor linked signaling pathway|cytokine biosynthetic process|humoral immune response|positive regulation of anti-apoptosis|positive regulation of interleukin-2 biosynthetic process|positive regulation of mitosis|positive regulation of translation|positive regulation of viral genome replication|regulation of defense response to virus by virus|regulatory T cell differentiation|T cell costimulation|viral reproduction	cytosol|external side of plasma membrane|integral to plasma membrane	coreceptor activity|protease binding|SH3/SH2 adaptor activity			endometrium(1)|kidney(2)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)|upper_aerodigestive_tract(1)	13						GTGCCCTAAGGGGATGGTGGC	0.532000													3	9					0	0	1	0	0
CHST12	55501	broad.mit.edu	37	7	2473140	2473140	+	Missense_Mutation	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr7:2473140G>A	ENST00000258711.6	+	2	1001	c.866G>A	c.(865-867)cGc>cAc	p.R289H		NM_001243794.1|NM_001243795.1|NM_018641.4	NP_001230723.1|NP_001230724.1|NP_061111.1	Q9NRB3	CHSTC_HUMAN	carbohydrate (chondroitin 4) sulfotransferase 12	289					dermatan sulfate biosynthetic process	integral to Golgi membrane	3'-phosphoadenosine 5'-phosphosulfate binding|chondroitin 4-sulfotransferase activity|protein binding			NS(1)|breast(1)|endometrium(1)|kidney(1)|large_intestine(6)|liver(1)|lung(7)|prostate(1)|skin(1)|urinary_tract(1)	21		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0847)|OV - Ovarian serous cystadenocarcinoma(56;2.25e-13)		GCCTCGGCGCGCGAGGCCTTC	0.652000													35	35					0	0	1	0	0
ITIH3	3699	broad.mit.edu	37	3	52833799	52833799	+	Missense_Mutation	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr3:52833799G>A	ENST00000449956.2	+	9	943	c.937G>A	c.(937-939)Gat>Aat	p.D313N	ITIH3_ENST00000465243.2_3'UTR|ITIH3_ENST00000416872.2_Missense_Mutation_p.D313N	NM_002217.3	NP_002208.3	Q06033	ITIH3_HUMAN	inter-alpha-trypsin inhibitor heavy chain 3	313	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(6)|liver(1)|lung(6)|ovary(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	25				BRCA - Breast invasive adenocarcinoma(193;7e-05)|Kidney(197;0.000656)|KIRC - Kidney renal clear cell carcinoma(197;0.000794)|OV - Ovarian serous cystadenocarcinoma(275;0.0496)		AATCCTGGAAGATATGCAAGA	0.537000													5	15					0	0	1	0	0
GLB1L3	112937	broad.mit.edu	37	11	134179612	134179612	+	Missense_Mutation	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr11:134179612G>A	ENST00000431683.2	+	11	1054	c.1054G>A	c.(1054-1056)Ggg>Agg	p.G352R		NM_001080407.2	NP_001073876.2	Q8NCI6	GLBL3_HUMAN	galactosidase, beta 1-like 3	352					carbohydrate metabolic process		cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			endometrium(4)|kidney(1)|large_intestine(3)|lung(4)|pancreas(1)	13	all_hematologic(175;0.127)	all_cancers(12;5.52e-23)|all_epithelial(12;2.15e-16)|all_lung(97;1.19e-05)|Lung NSC(97;2.76e-05)|Breast(109;0.000162)|all_neural(223;0.0182)|Medulloblastoma(222;0.0208)|Esophageal squamous(93;0.0559)		Epithelial(10;1.3e-11)|all cancers(11;2.07e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000873)|Lung(977;0.222)		TTTCATGAACGGGGCCACATA	0.483000													3	12					0	0	1	0	0
KIRREL3	84623	broad.mit.edu	37	11	126306737	126306737	+	Silent	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr11:126306737G>A	ENST00000525144.2	-	12	1770	c.1521C>T	c.(1519-1521)tcC>tcT	p.S507S	KIRREL3_ENST00000416561.2_5'UTR|KIRREL3_ENST00000525704.2_Silent_p.S507S|KIRREL3_ENST00000529097.2_Silent_p.S507S	NM_032531.3	NP_115920.1	Q8IZU9	KIRR3_HUMAN	kin of IRRE like 3 (Drosophila)	507	Ig-like C2-type 5.				hemopoiesis	extracellular region|integral to membrane|plasma membrane	protein binding	p.S466S(1)		central_nervous_system(1)|endometrium(5)|large_intestine(11)|lung(8)|ovary(3)|prostate(1)	29	all_hematologic(175;0.145)	Lung NSC(97;0.0484)|all_lung(97;0.0522)|Medulloblastoma(222;0.0523)|Breast(109;0.0949)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;6.03e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.12)		TCTCAGTGTCGGAGCCGAAGC	0.607000													16	22					0	0	1	0	0
EPG5	57724	broad.mit.edu	37	18	43437926	43437926	+	Missense_Mutation	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr18:43437926C>T	ENST00000282041.5	-	42	7368	c.7334G>A	c.(7333-7335)cGa>cAa	p.R2445Q	EPG5_ENST00000585906.1_5'UTR	NM_020964.2	NP_066015.2	Q9HCE0	EPG5_HUMAN	ectopic P-granules autophagy protein 5 homolog (C. elegans)	2445					autophagy					NS(1)|breast(9)|central_nervous_system(3)|cervix(3)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(22)|lung(35)|ovary(2)|pancreas(1)|prostate(3)|skin(1)|stomach(1)|upper_aerodigestive_tract(3)|urinary_tract(2)	95						GAGCAGAATTCGAATGACAGA	0.537000													21	34					0	0	1	0	0
CYLC1	1538	broad.mit.edu	37	X	83128836	83128836	+	Missense_Mutation	SNP	T	T	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chrX:83128836T>A	ENST00000329312.4	+	4	1157	c.1120T>A	c.(1120-1122)Tca>Aca	p.S374T		NM_021118.1	NP_066941.1	P35663	CYLC1_HUMAN	cylicin, basic protein of sperm head cytoskeleton 1	374					cell differentiation|multicellular organismal development|spermatogenesis	acrosomal matrix|cytoskeletal calyx	structural molecule activity			NS(2)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(11)|liver(1)|lung(22)|ovary(4)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(2)	58						TGATACTGAATCAGGAGATGC	0.323000													15	14					0	0	1	0	0
C1orf168	199920	broad.mit.edu	37	1	57206384	57206384	+	Silent	SNP	C	C	T	rs140363025		TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr1:57206384C>T	ENST00000343433.6	-	13	1769	c.1689G>A	c.(1687-1689)tcG>tcA	p.S563S	C1orf168_ENST00000484327.1_5'UTR	NM_001004303.4	NP_001004303.3	Q5VWT5	CA168_HUMAN	chromosome 1 open reading frame 168	563										NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(10)|lung(13)|ovary(3)|skin(6)|stomach(1)|urinary_tract(2)	46						AGTTTTCTTTCGACTTGGTTT	0.363000													7	13					0	0	1	0	0
EPS8L1	54869	broad.mit.edu	37	19	55593930	55593930	+	Missense_Mutation	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr19:55593930G>A	ENST00000201647.6	+	12	1230	c.1174G>A	c.(1174-1176)Gag>Aag	p.E392K	EPS8L1_ENST00000586329.1_Missense_Mutation_p.E374K|EPS8L1_ENST00000540810.1_Missense_Mutation_p.E328K|EPS8L1_ENST00000592824.1_3'UTR|EPS8L1_ENST00000245618.5_Missense_Mutation_p.E265K|EPS8L1_ENST00000588359.1_Missense_Mutation_p.E46K	NM_133180.2	NP_573441.2	Q8TE68	ES8L1_HUMAN	EPS8-like 1	392						cytoplasm				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(2)|lung(3)|ovary(1)|prostate(1)	12			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		ACGTGAAAACGAGCTCTGGAC	0.697000													6	10					0	0	1	0	0
CCDC148	130940	broad.mit.edu	37	2	159215037	159215037	+	Missense_Mutation	SNP	T	T	C			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr2:159215037T>C	ENST00000283233.5	-	2	384	c.71A>G	c.(70-72)tAc>tGc	p.Y24C	CCDC148_ENST00000409187.1_Missense_Mutation_p.Y33C|CCDC148_ENST00000409889.1_Missense_Mutation_p.Y24C|CCDC148_ENST00000536771.1_Intron	NM_138803.3	NP_620158.3	Q8NFR7	CC148_HUMAN	coiled-coil domain containing 148	24										endometrium(2)|kidney(2)|large_intestine(6)|lung(9)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	23						TACTGGTTTGTACTTGATGTT	0.328000													10	14					0	0	1	0	0
CDH26	60437	broad.mit.edu	37	20	58569315	58569315	+	Silent	SNP	G	G	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr20:58569315G>T	ENST00000348616.4	+	11	1737	c.1437G>T	c.(1435-1437)ccG>ccT	p.P479P	CDH26_ENST00000244047.5_Silent_p.P479P|CDH26_ENST00000497614.1_3'UTR	NM_177980.2	NP_817089.1	Q8IXH8	CAD26_HUMAN	cadherin 26	479	Cadherin 4.		P -> L (in dbSNP:rs6071067).		homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding	p.P479P(2)		breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(11)|lung(14)|ovary(4)|pancreas(2)|prostate(2)|skin(2)|urinary_tract(1)	44	all_lung(29;0.00963)		BRCA - Breast invasive adenocarcinoma(7;5.58e-09)			GCTTCCCACCGCAGACTGCTA	0.517000													25	34					9.04412e-07	9.28005e-07	1	1	0
AFF3	3899	broad.mit.edu	37	2	100266101	100266101	+	Missense_Mutation	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr2:100266101C>T	ENST00000317233.4	-	12	1406	c.1171G>A	c.(1171-1173)Gct>Act	p.A391T	AFF3_ENST00000409579.1_Missense_Mutation_p.A416T|AFF3_ENST00000409236.1_Missense_Mutation_p.A391T|AFF3_ENST00000356421.2_Missense_Mutation_p.A416T	NM_002285.2	NP_002276.2	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3	391					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			NS(1)|breast(3)|central_nervous_system(1)|cervix(3)|endometrium(9)|kidney(4)|large_intestine(20)|liver(1)|lung(28)|ovary(3)|pancreas(1)|prostate(4)|skin(5)|urinary_tract(3)	86						TCAGAGAGAGCGCGGAGAGCC	0.363000													18	60					0	0	1	0	0
PLXNB3	5365	broad.mit.edu	37	X	153039479	153039479	+	Missense_Mutation	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chrX:153039479C>T	ENST00000538966.1	+	21	3785	c.3514C>T	c.(3514-3516)Cgc>Tgc	p.R1172C	PLXNB3_ENST00000538282.1_Missense_Mutation_p.R759C|PLXNB3_ENST00000361971.5_Missense_Mutation_p.R1149C|PLXNB3_ENST00000538776.1_Missense_Mutation_p.R802C	NM_001163257.1	NP_001156729.1	Q9ULL4	PLXB3_HUMAN	plexin B3	1149	IPT/TIG 4.				axon guidance	integral to membrane|intracellular|plasma membrane	protein binding|receptor activity			central_nervous_system(1)|endometrium(7)|large_intestine(2)|lung(15)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	32	all_hematologic(71;4.25e-06)|all_lung(58;3.83e-05)|Lung NSC(58;5.54e-05)|Acute lymphoblastic leukemia(192;6.56e-05)					GCCCAACCCCCGCCTGGCACC	0.687000													15	34					0	0	1	0	0
CHM	1121	broad.mit.edu	37	X	85218875	85218875	+	Missense_Mutation	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chrX:85218875G>A	ENST00000357749.2	-	5	526	c.497C>T	c.(496-498)gCg>gTg	p.A166V	CHM_ENST00000537751.1_Missense_Mutation_p.A18V|CHM_ENST00000467744.1_Intron	NM_000390.2	NP_000381.1	P24386	RAE1_HUMAN	choroideremia (Rab escort protein 1)	166					intracellular protein transport|protein geranylgeranylation|response to stimulus|visual perception	Rab-protein geranylgeranyltransferase complex	GTPase activator activity|Rab geranylgeranyltransferase activity	p.A166V(1)		breast(1)|endometrium(1)|kidney(1)|large_intestine(2)|liver(1)|lung(12)|ovary(1)|prostate(1)	20		all_lung(315;5.41e-06)				TACTTCTAGCGCATTCTCTGG	0.443000													30	49					0	0	1	0	0
RHBDL3	162494	broad.mit.edu	37	17	30611720	30611720	+	Missense_Mutation	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr17:30611720C>T	ENST00000269051.4	+	3	192	c.178C>T	c.(178-180)Cgg>Tgg	p.R60W	RHBDL3_ENST00000536287.1_Intron|RHBDL3_ENST00000538145.1_Missense_Mutation_p.R52W	NM_138328.2	NP_612201.1	P58872	RHBL3_HUMAN	rhomboid, veinlet-like 3 (Drosophila)	60	EF-hand 1.				proteolysis	integral to membrane	calcium ion binding|serine-type endopeptidase activity			breast(1)|endometrium(1)|large_intestine(5)|lung(5)|ovary(1)|prostate(2)|skin(1)	16		Breast(31;0.116)|Ovarian(249;0.182)				AGGCAAGTTCCGGAGTCTTCT	0.592000													21	31					0	0	1	0	0
PTEN	5728	broad.mit.edu	37	10	89692980	89692980	+	Missense_Mutation	SNP	A	A	G			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr10:89692980A>G	ENST00000371953.3	+	5	1821	c.464A>G	c.(463-465)tAt>tGt	p.Y155C		NM_000314.4	NP_000305.3	P60484	PTEN_HUMAN	phosphatase and tensin homolog	155	Phosphatase tensin-type.		Y -> C (in CD; loss of phosphatase activity towards Ins(1,3,4,5)P4).		activation of mitotic anaphase-promoting complex activity|apoptosis|canonical Wnt receptor signaling pathway|cell proliferation|central nervous system development|induction of apoptosis|inositol phosphate dephosphorylation|negative regulation of cell migration|negative regulation of cyclin-dependent protein kinase activity involved in G1/S|negative regulation of focal adhesion assembly|negative regulation of G1/S transition of mitotic cell cycle|negative regulation of protein kinase B signaling cascade|negative regulation of protein phosphorylation|nerve growth factor receptor signaling pathway|phosphatidylinositol dephosphorylation|phosphatidylinositol-mediated signaling|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|positive regulation of sequence-specific DNA binding transcription factor activity|protein stabilization|regulation of neuron projection development|T cell receptor signaling pathway	cytosol|internal side of plasma membrane|PML body	anaphase-promoting complex binding|enzyme binding|inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity|lipid binding|magnesium ion binding|PDZ domain binding|phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity|phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity|phosphatidylinositol-3-phosphatase activity|protein serine/threonine phosphatase activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity	p.0?(37)|p.Y155C(7)|p.?(5)|p.R55fs*1(5)|p.Y27fs*1(2)|p.F56fs*2(1)		NS(28)|autonomic_ganglia(2)|biliary_tract(6)|bone(5)|breast(92)|central_nervous_system(676)|cervix(26)|endometrium(1068)|eye(8)|haematopoietic_and_lymphoid_tissue(137)|kidney(24)|large_intestine(98)|liver(20)|lung(91)|meninges(2)|oesophagus(2)|ovary(82)|pancreas(6)|prostate(129)|salivary_gland(5)|skin(127)|soft_tissue(19)|stomach(30)|testis(1)|thyroid(29)|upper_aerodigestive_tract(29)|urinary_tract(12)|vulva(17)	2771		all_cancers(4;3.61e-31)|all_epithelial(4;3.96e-23)|Prostate(4;8.12e-23)|Breast(4;0.000111)|Melanoma(5;0.00146)|all_hematologic(4;0.00227)|Colorectal(252;0.00494)|all_neural(4;0.00513)|Acute lymphoblastic leukemia(4;0.0116)|Glioma(4;0.0274)|all_lung(38;0.132)	KIRC - Kidney renal clear cell carcinoma(1;0.214)	UCEC - Uterine corpus endometrioid carcinoma (6;0.000228)|all cancers(1;4.16e-84)|GBM - Glioblastoma multiforme(1;7.77e-49)|Epithelial(1;7.67e-41)|OV - Ovarian serous cystadenocarcinoma(1;6.22e-15)|BRCA - Breast invasive adenocarcinoma(1;1.1e-06)|Lung(2;3.18e-06)|Colorectal(12;4.88e-06)|LUSC - Lung squamous cell carcinoma(2;4.97e-06)|COAD - Colon adenocarcinoma(12;1.13e-05)|Kidney(1;0.000288)|KIRC - Kidney renal clear cell carcinoma(1;0.00037)|STAD - Stomach adenocarcinoma(243;0.218)		CTAGATTTCTATGGGGAAGTA	0.373000		31	"""D, Mis, N, F, S"""		"""glioma,  prostate, endometrial"""	"""harmartoma, glioma,  prostate, endometrial"""			Proteus syndrome;Juvenile Polyposis;Hereditary Mixed Polyposis Syndrome type 1;Cowden syndrome;Bannayan-Riley-Ruvalcaba syndrome	HNSCC(9;0.0022)|TCGA GBM(2;<1E-08)|TSP Lung(26;0.18)			42	3					0	0	1	0	0
NSF	4905	broad.mit.edu	37	17	44782178	44782178	+	Silent	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr17:44782178G>A	ENST00000398238.4	+	13	1535	c.1428G>A	c.(1426-1428)acG>acA	p.T476T	NSF_ENST00000225282.8_Silent_p.T382T|NSF_ENST00000575068.1_Silent_p.T471T	NM_006178.3	NP_006169.2	P46459	NSF_HUMAN	N-ethylmaleimide-sensitive factor	476			T -> M (in dbSNP:rs155733).		protein transport|synaptic transmission	cytosol	ATP binding|metal ion binding			kidney(2)|large_intestine(1)|liver(2)|lung(7)|ovary(1)|upper_aerodigestive_tract(1)	14		Melanoma(429;0.203)	BRCA - Breast invasive adenocarcinoma(9;0.0257)	BRCA - Breast invasive adenocarcinoma(366;0.241)		TGCAAGTGACGAGAGGAGACT	0.383000													21	34					0	0	1	0	0
BFAR	51283	broad.mit.edu	37	16	14743799	14743799	+	Missense_Mutation	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr16:14743799G>A	ENST00000261658.2	+	4	884	c.607G>A	c.(607-609)Gaa>Aaa	p.E203K	BFAR_ENST00000563971.1_Intron|BFAR_ENST00000426842.2_Missense_Mutation_p.E75K	NM_016561.2	NP_057645.1	Q9NZS9	BFAR_HUMAN	bifunctional apoptosis regulator	203	SAM.				anti-apoptosis|apoptosis	endoplasmic reticulum membrane|integral to plasma membrane|membrane fraction	structural molecule activity|zinc ion binding			endometrium(4)|kidney(1)|large_intestine(2)|lung(1)|ovary(2)|skin(1)	11						TCTTTACAGGGAAAGGTTTTT	0.493000													17	33					0	0	1	0	0
MRGPRX3	117195	broad.mit.edu	37	11	18159005	18159005	+	Missense_Mutation	SNP	C	C	T	rs141255495		TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr11:18159005C>T	ENST00000396275.2	+	3	617	c.256C>T	c.(256-258)Cgc>Tgc	p.R86C		NM_054031.3	NP_473372.3	Q96LB0	MRGX3_HUMAN	MAS-related GPR, member X3	86						integral to membrane|plasma membrane	G-protein coupled receptor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(5)|lung(10)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	27						TTCGCCGTTACGCCTCATCAA	0.547000													45	67					0	0	1	0	0
ADCY6	112	broad.mit.edu	37	12	49169177	49169177	+	Missense_Mutation	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr12:49169177C>T	ENST00000307885.4	-	10	2583	c.1889G>A	c.(1888-1890)cGt>cAt	p.R630H	ADCY6_ENST00000550422.1_Missense_Mutation_p.R630H|ADCY6_ENST00000357869.3_Missense_Mutation_p.R630H|ADCY6_ENST00000552090.1_5'UTR	NM_015270.3	NP_056085.1	O43306	ADCY6_HUMAN	adenylate cyclase 6	630					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane	ATP binding|metal ion binding			breast(1)|endometrium(6)|kidney(1)|large_intestine(2)|lung(16)|prostate(1)|skin(1)|urinary_tract(1)	29						ATCGATGGCACGGCTCAGGAA	0.587000													35	37					0	0	1	0	0
RHOXF1	158800	broad.mit.edu	37	X	119249405	119249405	+	Missense_Mutation	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chrX:119249405C>T	ENST00000217999.2	-	1	442	c.368G>A	c.(367-369)cGa>cAa	p.R123Q	RP4-755D9.1_ENST00000553843.1_RNA	NM_139282.1	NP_644811.1	Q8NHV9	RHXF1_HUMAN	Rhox homeobox family, member 1	123					gamete generation|multicellular organismal development|steroid hormone receptor signaling pathway	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|endometrium(1)|large_intestine(1)|lung(5)|ovary(1)|prostate(1)	10						TTGAGTGTGTCGGAAAACACT	0.577000													37	51					0	0	1	0	0
KIAA1217	56243	broad.mit.edu	37	10	24810839	24810839	+	Missense_Mutation	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr10:24810839G>A	ENST00000376451.2	+	7	1746	c.1486G>A	c.(1486-1488)Gtc>Atc	p.V496I	KIAA1217_ENST00000458595.1_Missense_Mutation_p.V778I|KIAA1217_ENST00000376454.3_Missense_Mutation_p.V813I|KIAA1217_ENST00000430453.2_Intron|KIAA1217_ENST00000376452.3_Missense_Mutation_p.V778I|KIAA1217_ENST00000396445.1_Missense_Mutation_p.V496I|KIAA1217_ENST00000396446.1_Missense_Mutation_p.V496I|KIAA1217_ENST00000376462.1_Missense_Mutation_p.V733I|KIAA1217_ENST00000307544.6_Missense_Mutation_p.V496I			Q5T5P2	SKT_HUMAN	KIAA1217	813					embryonic skeletal system development	cytoplasm				breast(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(4)|kidney(3)|large_intestine(19)|lung(19)|ovary(5)|prostate(3)|skin(3)|urinary_tract(1)	70						CATGACAGACGTCCTGACCAT	0.632000													29	35					0	0	1	0	0
TPTE2P6	0	broad.mit.edu	37	13	25161397	25161397	+	RNA	SNP	C	C	G	rs3874227	by1000genomes	TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr13:25161397C>G	ENST00000453498.1	+	0	921																											TGAAACATCTCTACAACTGGA	0.343000													3	16					0	0	1	0	0
OR4C6	219432	broad.mit.edu	37	11	55432696	55432696	+	Missense_Mutation	SNP	C	C	G			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr11:55432696C>G	ENST00000314259.3	+	1	83	c.54C>G	c.(52-54)aaC>aaG	p.N18K		NM_001004704.1	NP_001004704.1	Q8NH72	OR4C6_HUMAN	olfactory receptor, family 4, subfamily C, member 6	18					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(2)|cervix(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(4)|lung(49)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	71						TCACAGAGAACCTGGAGCTGT	0.383000													33	50					0	0	1	0	0
PGS1	9489	broad.mit.edu	37	17	76395556	76395556	+	Silent	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr17:76395556C>T	ENST00000262764.6	+	5	665	c.639C>T	c.(637-639)aaC>aaT	p.N213N	PGS1_ENST00000588281.1_3'UTR|PGS1_ENST00000329897.7_Silent_p.N78N	NM_024419.3	NP_077733.3	Q32NB8	PGPS1_HUMAN	phosphatidylglycerophosphate synthase 1	213					phospholipid biosynthetic process	endoplasmic reticulum|mitochondrion	ATP binding|CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity			cervix(2)|endometrium(1)|large_intestine(1)|lung(3)|prostate(1)|skin(1)|urinary_tract(1)	10			BRCA - Breast invasive adenocarcinoma(99;0.00144)|OV - Ovarian serous cystadenocarcinoma(97;0.031)			AGCGCTTCAACGAGACCATCG	0.607000													38	60					0	0	1	0	0
RPS6KC1	26750	broad.mit.edu	37	1	213302876	213302876	+	Missense_Mutation	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr1:213302876C>T	ENST00000366960.3	+	6	629	c.479C>T	c.(478-480)tCc>tTc	p.S160F	RPS6KC1_ENST00000366959.3_Missense_Mutation_p.S148F|RPS6KC1_ENST00000543354.1_Intron|RPS6KC1_ENST00000490299.1_3'UTR|RPS6KC1_ENST00000543470.1_5'UTR	NM_012424.3	NP_036556.2	Q96S38	KS6C1_HUMAN	ribosomal protein S6 kinase, 52kDa, polypeptide 1	160					cell communication|signal transduction	early endosome|membrane	ATP binding|phosphatidylinositol binding|protein binding|protein serine/threonine kinase activity			breast(1)|endometrium(6)|kidney(4)|large_intestine(8)|liver(2)|lung(15)|ovary(3)|prostate(1)|urinary_tract(3)	43				OV - Ovarian serous cystadenocarcinoma(81;0.00705)|all cancers(67;0.016)|GBM - Glioblastoma multiforme(131;0.0663)|Epithelial(68;0.145)		CTAGGCTTCTCCAGTGACAGT	0.333000													21	43					0	0	1	0	0
PCDHB5	0	broad.mit.edu	37	5	140515028	140515028	+	Silent	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr5:140515028G>A	ENST00000231134.5	+	1	229	c.12G>A	c.(10-12)gcG>gcA	p.A4A		NM_015669.2	NP_056484.1	Q9Y5E4	PCDB5_HUMAN		4					calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			breast(2)|central_nervous_system(1)|cervix(1)|endometrium(12)|kidney(1)|large_intestine(18)|lung(25)|ovary(3)|prostate(6)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(2)	81			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGGAGACTGCGCTAGCAAAAA	0.463000													24	57					0	0	1	0	0
ADAT3	113179	broad.mit.edu	37	19	1912242	1912242	+	Missense_Mutation	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr19:1912242G>A	ENST00000329478.2	+	2	416	c.196G>A	c.(196-198)Gtc>Atc	p.V66I	ADAT3_ENST00000602400.1_Missense_Mutation_p.V50I|SCAMP4_ENST00000414057.2_Intron|SCAMP4_ENST00000409472.1_Intron|SCAMP4_ENST00000316097.8_Intron			Q96EY9	ADAT3_HUMAN	adenosine deaminase, tRNA-specific 3	50					tRNA processing		hydrolase activity|zinc ion binding			breast(1)|kidney(3)|pancreas(1)|skin(2)	7		Ovarian(11;2.11e-07)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		CGCCGCGCCCGTCCTGGACAA	0.736000													8	7					0	0	1	0	0
AFF2	2334	broad.mit.edu	37	X	147924917	147924917	+	Missense_Mutation	SNP	C	C	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chrX:147924917C>A	ENST00000370460.2	+	7	1701	c.1222C>A	c.(1222-1224)Cca>Aca	p.P408T	AFF2_ENST00000370457.5_Missense_Mutation_p.P375T|AFF2_ENST00000342251.3_Missense_Mutation_p.P375T|AFF2_ENST00000370458.1_Missense_Mutation_p.P375T|AFF2_ENST00000286437.5_Missense_Mutation_p.P49T	NM_001169123.1|NM_002025.3	NP_001162594.1|NP_002016.2	P51816	AFF2_HUMAN	AF4/FMR2 family, member 2	408					brain development|mRNA processing|regulation of RNA splicing|RNA splicing	nuclear speck	G-quadruplex RNA binding|protein binding			breast(5)|central_nervous_system(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(29)|liver(2)|lung(39)|ovary(4)|pancreas(5)|prostate(1)|skin(7)|upper_aerodigestive_tract(1)|urinary_tract(1)	109	Acute lymphoblastic leukemia(192;6.56e-05)					GTGGAATGACCCAACCACCAG	0.388000													23	36					2.21704e-12	2.3358e-12	1	1	0
DMBT1	1755	broad.mit.edu	37	10	124389946	124389946	+	Nonsense_Mutation	SNP	C	C	T	rs143073434	by1000genomes	TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr10:124389946C>T	ENST00000338354.3	+	45	5684	c.5578C>T	c.(5578-5580)Cga>Tga	p.R1860*	DMBT1_ENST00000368955.3_Nonsense_Mutation_p.R1850*|DMBT1_ENST00000368909.3_Nonsense_Mutation_p.R1860*|DMBT1_ENST00000368956.2_Nonsense_Mutation_p.R1232*|DMBT1_ENST00000330163.4_Nonsense_Mutation_p.R1232*|DMBT1_ENST00000359586.6_Nonsense_Mutation_p.R580*|DMBT1_ENST00000344338.3_Nonsense_Mutation_p.R1850*			Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1	1860	CUB 1.		R -> L (in dbSNP:rs7099177).		epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			breast(2)|central_nervous_system(7)|cervix(3)|endometrium(8)|kidney(1)|large_intestine(1)|lung(46)|prostate(1)|urinary_tract(3)	72		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				CATTCACTTTCGAAGTGACAT	0.428000													42	8					0	0	1	0	0
EXOC4	60412	broad.mit.edu	37	7	133692545	133692545	+	Missense_Mutation	SNP	A	A	G			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr7:133692545A>G	ENST00000253861.4	+	17	2673	c.2644A>G	c.(2644-2646)Acc>Gcc	p.T882A	EXOC4_ENST00000541309.1_Missense_Mutation_p.T170A|EXOC4_ENST00000545148.1_Missense_Mutation_p.T492A|EXOC4_ENST00000539845.1_Missense_Mutation_p.T781A	NM_021807.3	NP_068579.3	Q96A65	EXOC4_HUMAN	exocyst complex component 4	882					vesicle docking involved in exocytosis	exocyst	protein N-terminus binding			NS(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(10)|lung(16)|ovary(4)|prostate(1)|skin(5)|upper_aerodigestive_tract(2)	50		Esophageal squamous(399;0.129)				GCAGAATTTGACCAACATCAC	0.473000													14	26					0	0	1	0	0
EXOC3L1	283849	broad.mit.edu	37	16	67219060	67219060	+	Silent	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr16:67219060G>A	ENST00000314586.6	-	11	1968	c.1728C>T	c.(1726-1728)cgC>cgT	p.R576R		NM_178516.3	NP_848611.2	Q86VI1	EX3L1_HUMAN	exocyst complex component 3-like 1	576					exocytosis|peptide hormone secretion	exocyst|stored secretory granule|transport vesicle				breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(6)|ovary(1)|skin(3)|upper_aerodigestive_tract(1)	21						GGTTCCGCACGCGCCAGAAGT	0.677000													51	53					0	0	1	0	0
CDC42EP2	10435	broad.mit.edu	37	11	65088659	65088659	+	Missense_Mutation	SNP	C	C	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr11:65088659C>T	ENST00000544348.1	+	2	896	c.290C>T	c.(289-291)cCg>cTg	p.P97L	CDC42EP2_ENST00000533419.1_Missense_Mutation_p.P97L|CDC42EP2_ENST00000279249.2_Missense_Mutation_p.P97L			O14613	BORG1_HUMAN	CDC42 effector protein (Rho GTPase binding) 2	97					actin filament organization|positive regulation of actin filament polymerization|positive regulation of pseudopodium assembly|regulation of cell shape	cytoplasm|cytoskeleton|endomembrane system|plasma membrane	GTP-Rho binding|Rho GTPase activator activity			lung(1)	1						CGGGAGCTCCCGGACGGCCCA	0.682000													29	44					0	0	1	0	0
CCR6	1235	broad.mit.edu	37	6	167550589	167550589	+	Missense_Mutation	SNP	G	G	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr6:167550589G>A	ENST00000341935.5	+	3	1423	c.871G>A	c.(871-873)Gaa>Aaa	p.E291K	CCR6_ENST00000349984.4_Missense_Mutation_p.E291K|CCR6_ENST00000400926.2_Missense_Mutation_p.E291K	NM_031409.3	NP_113597.2	P51684	CCR6_HUMAN	chemokine (C-C motif) receptor 6	291					cellular defense response|dendritic cell chemotaxis|elevation of cytosolic calcium ion concentration|humoral immune response	integral to plasma membrane	C-C chemokine receptor activity			endometrium(3)|kidney(2)|large_intestine(2)|lung(5)|ovary(1)|prostate(1)	14		Breast(66;1.53e-05)|Ovarian(120;0.0606)		OV - Ovarian serous cystadenocarcinoma(33;8.21e-20)|BRCA - Breast invasive adenocarcinoma(81;4.55e-06)|GBM - Glioblastoma multiforme(31;0.00507)		CTGCCAGAGCGAAAAGCTAAT	0.483000													35	66					0	0	1	0	0
SEC22B	9554	broad.mit.edu	37	1	145116147	145116148	+	RNA	INS	-	-	A	rs138980379		TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr1:145116147_145116148insA	ENST00000453618.1	+	0	1233_1234							O75396	SC22B_HUMAN	SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)						ER to Golgi vesicle-mediated transport|protein transport	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|integral to membrane|melanosome	protein binding										AGTAGATTGTTATTTCGTTTTT	0.416													3	5	---	---	---	---					
IARS2	55699	broad.mit.edu	37	1	220287663	220287664	+	Frame_Shift_Ins	INS	-	-	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr1:220287663_220287664insA	ENST00000366922.1	+	12	1602_1603	c.1271_1272insA	c.(1270-1272)taafs	p.*424fs	IARS2_ENST00000302637.5_Frame_Shift_Ins_p.*496fs			Q9NSE4	SYIM_HUMAN	isoleucyl-tRNA synthetase 2, mitochondrial	496					isoleucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|isoleucine-tRNA ligase activity			NS(1)|breast(1)|cervix(2)|endometrium(7)|kidney(4)|large_intestine(7)|lung(17)|ovary(2)|prostate(4)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)	51				GBM - Glioblastoma multiforme(131;0.0554)	L-Isoleucine(DB00167)	CAGGAATTGTTAAAAAAGGTGA	0.366													22	59	---	---	---	---					
SCN5A	6331	broad.mit.edu	37	3	38592967	38592977	+	Frame_Shift_Del	DEL	GCGGCCTATTC	GCGGCCTATTC	-			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr3:38592967_38592977delGCGGCCTATTC	ENST00000413689.1	-	28	5079_5089	c.4886_4896delGAATAGGCCGC	c.(4885-4896)cfs	p.RIGR1629fs	SCN5A_ENST00000455624.2_Frame_Shift_Del_p.RIGR1596fs|SCN5A_ENST00000425664.1_Frame_Shift_Del_p.RIGR1611fs|SCN5A_ENST00000414099.2_Frame_Shift_Del_p.RIGR1611fs|SCN5A_ENST00000451551.2_Frame_Shift_Del_p.RIGR1575fs|SCN5A_ENST00000333535.4_Frame_Shift_Del_p.RIGR1629fs|SCN5A_ENST00000450102.2_Frame_Shift_Del_p.RIGR1575fs|SCN5A_ENST00000449557.2_Frame_Shift_Del_p.RIGR1575fs|SCN5A_ENST00000423572.2_Frame_Shift_Del_p.RIGR1628fs|SCN5A_ENST00000443581.1_Frame_Shift_Del_p.RIGR1628fs	NM_001099404.1|NM_001160160.1	NP_001092874.1|NP_001153632.1	Q14524	SCN5A_HUMAN	sodium channel, voltage-gated, type V, alpha subunit	1629					blood circulation|cellular response to calcium ion|muscle contraction|regulation of heart contraction	sarcolemma|voltage-gated sodium channel complex	protein binding|voltage-gated sodium channel activity	p.I1630I(2)		NS(3)|breast(2)|central_nervous_system(3)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(25)|lung(27)|ovary(6)|pancreas(3)|prostate(10)|skin(9)|upper_aerodigestive_tract(4)	107	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0822)|Kidney(284;0.1)	Benzonatate(DB00868)|Bepridil(DB01244)|Carbamazepine(DB00564)|Cocaine(DB00907)|Dibucaine(DB00527)|Disopyramide(DB00280)|Encainide(DB01228)|Ethotoin(DB00754)|Flecainide(DB01195)|Fosphenytoin(DB01320)|Hexylcaine(DB00473)|Indecainide(DB00192)|Lamotrigine(DB00555)|Lidocaine(DB00281)|Mephenytoin(DB00532)|Mexiletine(DB00379)|Mibefradil(DB01388)|Moricizine(DB00680)|Oxcarbazepine(DB00776)|Phenytoin(DB00252)|Prilocaine(DB00750)|Procainamide(DB01035)|Propafenone(DB01182)|Quinidine(DB00908)|Riluzole(DB00740)|Tocainide(DB01056)|Verapamil(DB00661)	GTCTGAGGATGCGGCCTATTCGGGCCAGGCG	0.592													13	116	---	---	---	---					
SOGA3	387104	broad.mit.edu	37	6	127836020	127836021	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr6:127836020_127836021delTG	ENST00000556132.1	-	3	2137_2138	c.1273_1274delCA	c.(1273-1275)gfs	p.Q425fs	SOGA3_ENST00000481848.2_Frame_Shift_Del_p.Q425fs|SOGA3_ENST00000465909.2_Frame_Shift_Del_p.Q425fs|SOGA3_ENST00000368268.2_Frame_Shift_Del_p.Q425fs|SOGA3_ENST00000525778.1_Frame_Shift_Del_p.Q425fs	NM_001012279.2	NP_001012279.1	Q5TF21	CF174_HUMAN	SOGA family member 3	425						integral to membrane											TTCCCCGGTCTGGGCGTAGCGG	0.663													30	52	---	---	---	---					
ERICH1-AS1	0	broad.mit.edu	37	8	844731	844732	+	RNA	INS	-	-	G			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr8:844731_844732insG	ENST00000524139.1	+	0	151				ERICH1-AS1_ENST00000577187.1_RNA|ERICH1-AS1_ENST00000578889.1_RNA|ERICH1-AS1_ENST00000522092.1_RNA																							GGTGGCTGGCAGGGCAGGGTGG	0.713													4	2	---	---	---	---					
CTD-2281E23.3	0	broad.mit.edu	37	8	1197168	1197168	+	RNA	DEL	G	G	-	rs67975971		TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr8:1197168delG	ENST00000517950.1	-	0	278																											AGATCAGTGTGGGAGTGATGG	0.592													2	4	---	---	---	---					
MIRLET7DHG	0	broad.mit.edu	37	9	96941099	96941100	+	RNA	INS	-	-	A			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr9:96941099_96941100insA	ENST00000416309.2	-	0	164				RP11-2B6.3_ENST00000602703.1_lincRNA	NR_046163.1																						AGACCAGCAAGAAAAAAAAAAT	0.376													2	4	---	---	---	---					
CEL	1056	broad.mit.edu	37	9	135946658	135946658	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr9:135946658delC	ENST00000372080.4	+	11	1794	c.1778delC	c.(1777-1779)gcfs	p.A593fs	CEL_ENST00000351304.7_Frame_Shift_Del_p.A524fs	NM_001807.3	NP_001798.2	P19835	CEL_HUMAN	carboxyl ester lipase	590	17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type).				cholesterol catabolic process|fatty acid catabolic process|intestinal cholesterol absorption|intestinal lipid catabolic process|pancreatic juice secretion|protein esterification	cytosol|extracellular space	acylglycerol lipase activity|carboxylesterase activity|heparin binding|sterol esterase activity|triglyceride lipase activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|pancreas(2)|skin(1)	20				OV - Ovarian serous cystadenocarcinoma(145;1.03e-40)|Epithelial(140;3.58e-37)|GBM - Glioblastoma multiforme(294;0.00164)|READ - Rectum adenocarcinoma(205;0.196)		GACTCCGGGGCCCCCCCCGTG	0.816													2	4	---	---	---	---					
RP11-229P13.22	0	broad.mit.edu	37	9	139954080	139954080	+	RNA	DEL	T	T	-			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr9:139954080delT	ENST00000435463.2	+	0	167																											ATTGCTTTAATTTTTTTTAAA	0.418													2	4	---	---	---	---					
NET1	10276	broad.mit.edu	37	10	5496339	5496341	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr10:5496339_5496341delCTC	ENST00000355029.4	+	9	1022_1024	c.880_882delCTC	c.(880-882)del	p.L294del	NET1_ENST00000380359.3_In_Frame_Del_p.L240del|NET1_ENST00000542715.1_In_Frame_Del_p.L113del	NM_001047160.1	NP_001040625.1	Q7Z628	ARHG8_HUMAN	neuroepithelial cell transforming 1	294	DH.				apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of cell growth|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|nucleus	Rho guanyl-nucleotide exchange factor activity	p.L240I(1)|p.L294I(1)		breast(4)|kidney(2)|large_intestine(9)|lung(5)|prostate(2)|skin(1)	23						CCAGCGATGTCTCGAGTCTCCCT	0.433													22	27	---	---	---	---					
DGKZ	8525	broad.mit.edu	37	11	46388900	46388900	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr11:46388900delC	ENST00000454345.1	+	3	913	c.788delC	c.(787-789)gcfs	p.A263fs	DGKZ_ENST00000528615.1_Intron|DGKZ_ENST00000543978.1_Intron|DGKZ_ENST00000395574.3_Frame_Shift_Del_p.A40fs|DGKZ_ENST00000525434.1_3'UTR|DGKZ_ENST00000532868.2_Frame_Shift_Del_p.A79fs|DGKZ_ENST00000318201.8_Frame_Shift_Del_p.A74fs|DGKZ_ENST00000421244.2_Frame_Shift_Del_p.A74fs|DGKZ_ENST00000456247.2_Frame_Shift_Del_p.A74fs|DGKZ_ENST00000343674.6_Frame_Shift_Del_p.A91fs|DGKZ_ENST00000527911.1_Frame_Shift_Del_p.A74fs	NM_001105540.1	NP_001099010.1	Q13574	DGKZ_HUMAN	diacylglycerol kinase, zeta	263					activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|cell migration|intracellular signal transduction|mitotic cell cycle G1/S transition DNA damage checkpoint|negative regulation of mitotic cell cycle|platelet activation	cytoplasm|lamellipodium|nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|lipid kinase activity|metal ion binding|protein binding|protein C-terminus binding			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(5)|lung(12)|pancreas(1)|prostate(1)|skin(1)	25				GBM - Glioblastoma multiforme(35;0.0259)|Lung(87;0.141)		ACCCCTGGGGCCCCGTGCAGC	0.662													21	29	---	---	---	---					
DCP1B	196513	broad.mit.edu	37	12	2062350	2062351	+	In_Frame_Ins	INS	-	-	TGG			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr12:2062350_2062351insTGG	ENST00000280665.6	-	7	834_835	c.755_756insCCA	c.(754-756)cca>cCCAca	p.252_253insT	DCP1B_ENST00000540622.1_In_Frame_Ins_p.126_127insT|DCP1B_ENST00000397173.4_In_Frame_Ins_p.150_151insT|DCP1B_ENST00000541700.1_5'UTR	NM_152640.3	NP_689853.3	Q8IZD4	DCP1B_HUMAN	decapping mRNA 1B	252	Poly-Gln.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytosol|nucleus	hydrolase activity|protein binding	p.Q252H(8)		NS(1)|breast(1)|endometrium(6)|kidney(2)|large_intestine(3)|lung(10)|skin(1)	24			OV - Ovarian serous cystadenocarcinoma(31;0.00193)			gctgctgctgctgGTGGAGAGT	0.550													22	34	---	---	---	---					
BCL11B	64919	broad.mit.edu	37	14	99641543	99641544	+	In_Frame_Ins	INS	-	-	CTC			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr14:99641543_99641544insCTC	ENST00000345514.2	-	3	1682_1683	c.1416_1417insGAG	c.(1414-1419)gatgct>gaGAGtgct	p.472_472D>ES	BCL11B_ENST00000443726.2_In_Frame_Ins_p.349_349D>ES|BCL11B_ENST00000357195.3_In_Frame_Ins_p.543_543D>ES	NM_022898.1	NP_075049.1	Q9C0K0	BC11B_HUMAN	B-cell CLL/lymphoma 11B (zinc finger protein)	543						nucleus	zinc ion binding			NS(3)|breast(1)|central_nervous_system(9)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(2)|lung(9)|prostate(2)|skin(2)	34		Melanoma(154;0.0866)|all_epithelial(191;0.241)		COAD - Colon adenocarcinoma(157;0.103)		TCCAGTAGCAGctcctcctcct	0.698			T	TLX3	T-ALL								3	5	---	---	---	---					
ULK4P3	0	broad.mit.edu	37	15	30406088	30406089	+	RNA	INS	-	-	T			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr15:30406088_30406089insT	ENST00000568486.1	+	0	402					NR_026859.1																						TGCCTCAAAAGTTTTTTTTTTT	0.297													4	8	---	---	---	---					
SPIRE2	84501	broad.mit.edu	37	16	89895123	89895123	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chr16:89895123delG	ENST00000378247.3	+	1	208	c.165delG	c.(163-165)ccfs	p.P55fs	SPIRE2_ENST00000564878.1_Intron|SPIRE2_ENST00000563972.1_Frame_Shift_Del_p.P55fs|SPIRE2_ENST00000393062.2_Frame_Shift_Del_p.P55fs	NM_032451.1	NP_115827.1	Q8WWL2	SPIR2_HUMAN	spire-type actin nucleation factor 2	55	KIND.				transport	cytoplasm|cytoskeleton	actin binding			central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(1)|lung(10)|upper_aerodigestive_tract(2)|urinary_tract(1)	21		Lung NSC(15;5.15e-06)|all_lung(18;8.38e-06)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0286)		GGGGCTCGCCGGGCCGGCGCC	0.781													2	4	---	---	---	---					
BCORL1	63035	broad.mit.edu	37	X	129149592	129149592	+	Frame_Shift_Del	DEL	G	G	-			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chrX:129149592delG	ENST00000540052.1	+	3	2888	c.2844delG	c.(2842-2844)cafs	p.Q948fs	BCORL1_ENST00000218147.7_Frame_Shift_Del_p.Q948fs|BCORL1_ENST00000303743.5_Frame_Shift_Del_p.Q948fs|BCORL1_ENST00000359304.2_Frame_Shift_Del_p.Q948fs	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	948					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						GAATGAATCAGGGGCCTGAGG	0.577													39	79	---	---	---	---					
BCORL1	63035	broad.mit.edu	37	X	129190033	129190034	+	Frame_Shift_Del	DEL	TG	TG	-			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chrX:129190033_129190034delTG	ENST00000540052.1	+	12	5102_5103	c.5058_5059delTG	c.(5056-5061)actgfs	p.TV1686fs	BCORL1_ENST00000218147.7_Frame_Shift_Del_p.TV1686fs|BCORL1_ENST00000303743.5_Frame_Shift_Del_p.TV1760fs|BCORL1_ENST00000359304.2_Frame_Shift_Del_p.TV1556fs	NM_021946.4	NP_068765.3	Q5H9F3	BCORL_HUMAN	BCL6 corepressor-like 1	1686					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				breast(4)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(9)|liver(3)|lung(30)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	75						CCTCTGAGACTGTGGAGCTGGT	0.619													26	67	---	---	---	---					
MAMLD1	10046	broad.mit.edu	37	X	149639633	149639635	+	In_Frame_Del	DEL	GCA	GCA	-			TCGA-N6-A4VD-01A-11D-A28R-08	TCGA-N6-A4VD-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	2d33a481-d2dd-4205-86a8-bf35b0de3a71	cda4ae33-d178-4d5d-8f91-aa585bcf4a79	g.chrX:149639633_149639635delGCA	ENST00000370401.2	+	4	2098_2100	c.1788_1790delGCA	c.(1786-1791)ctg>ct	p.LQ596del	MAMLD1_ENST00000426613.2_In_Frame_Del_p.LQ571del|MAMLD1_ENST00000432680.2_In_Frame_Del_p.LQ571del|MAMLD1_ENST00000262858.5_In_Frame_Del_p.LQ596del|MAMLD1_ENST00000455522.2_In_Frame_Del_p.LQ77del			Q13495	MAMD1_HUMAN	mastermind-like domain containing 1	596	Poly-Gln.				male gonad development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				breast(1)|endometrium(4)|kidney(3)|large_intestine(12)|lung(14)|ovary(1)|prostate(2)	37	Acute lymphoblastic leukemia(192;6.56e-05)					CCTTgcagctgcagcagcagcag	0.611													7	155	---	---	---	---					
