Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
AC016995.3	0	broad.mit.edu	37	2	38709067	38709067	+	RNA	SNP	A	A	G	rs113173138		TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr2:38709067A>G	ENST00000417039.1	-	0	696																											ATGATTATCCAAAATGTTTCA	0.537000													22	143					0	0	1	0	0
CC2D2A	57545	broad.mit.edu	37	4	15572024	15572024	+	Missense_Mutation	SNP	G	G	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr4:15572024G>T	ENST00000424120.1	+	28	3753	c.3499G>T	c.(3499-3501)Gac>Tac	p.D1167Y	CC2D2A_ENST00000389652.5_Missense_Mutation_p.D1118Y|CC2D2A_ENST00000503292.1_Missense_Mutation_p.D1167Y|CC2D2A_ENST00000413206.1_Missense_Mutation_p.D1167Y			Q9P2K1	C2D2A_HUMAN	coiled-coil and C2 domain containing 2A	1167	C2.				cell projection organization	cilium|microtubule basal body				NS(1)|breast(2)|central_nervous_system(1)|endometrium(6)|kidney(1)|large_intestine(8)|lung(5)|ovary(1)|pancreas(2)|prostate(2)|skin(1)|urinary_tract(2)	32						CCTTTAGGATGACCGTGAAAG	0.408000													10	42					1.58986e-06	1.62573e-06	1	1	0
ZNF615	284370	broad.mit.edu	37	19	52497760	52497760	+	Missense_Mutation	SNP	T	T	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr19:52497760T>C	ENST00000602063.1	-	6	918	c.569A>G	c.(568-570)cAg>cGg	p.Q190R	ZNF615_ENST00000598071.1_Missense_Mutation_p.Q201R|ZNF615_ENST00000391795.3_Missense_Mutation_p.Q195R|ZNF615_ENST00000376716.5_Missense_Mutation_p.Q190R|ZNF615_ENST00000594083.1_Missense_Mutation_p.Q201R			Q8N8J6	ZN615_HUMAN	zinc finger protein 615	190					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(5)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	42		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		CTTAATGAACTGGGACTTATT	0.363000													119	854					0	0	1	0	0
ZNF514	84874	broad.mit.edu	37	2	95815575	95815575	+	Missense_Mutation	SNP	G	G	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr2:95815575G>T	ENST00000295208.2	-	5	1117	c.655C>A	c.(655-657)Ctt>Att	p.L219I	ZNF514_ENST00000411425.1_Missense_Mutation_p.L219I	NM_032788.1	NP_116177.1	Q96K75	ZN514_HUMAN	zinc finger protein 514	219					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(4)|lung(6)|urinary_tract(1)	11						TGGCGCCTAAGTTCTGACTGG	0.443000													26	783					4.06085e-26	4.4182e-26	1	1	0
TRAV6	0	broad.mit.edu	37	14	22236771	22236771	+	RNA	SNP	C	C	T	rs11623408	by1000genomes	TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr14:22236771C>T	ENST00000390428.3	+	0	43																											GTCTACATTTCAGGCCACATT	0.468000													27	906					0	0	1	0	0
CHD8	57680	broad.mit.edu	37	14	21861651	21861651	+	Silent	SNP	C	C	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr14:21861651C>T	ENST00000399982.2	-	31	6367	c.6303G>A	c.(6301-6303)gaG>gaA	p.E2101E	CHD8_ENST00000557364.1_Silent_p.E2101E|CHD8_ENST00000430710.3_Silent_p.E1822E	NM_001170629.1	NP_001164100.1	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	2101					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			NS(2)|breast(1)|central_nervous_system(1)|cervix(4)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(8)|lung(33)|ovary(6)|prostate(7)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(2)	85	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		TCTCTTCCTTCTCATCCTCAC	0.498000													7	37					0	0	1	0	0
C1orf162	128346	broad.mit.edu	37	1	112020662	112020662	+	Missense_Mutation	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr1:112020662G>A	ENST00000343534.5	+	6	635	c.385G>A	c.(385-387)Gaa>Aaa	p.E129K	C1orf162_ENST00000464591.1_3'UTR|C1orf162_ENST00000369718.3_Missense_Mutation_p.E104K	NM_174896.2	NP_777556.1	Q8NEQ5	CA162_HUMAN	chromosome 1 open reading frame 162	129						integral to membrane				NS(1)|kidney(1)|large_intestine(1)|lung(1)|ovary(1)	5		all_cancers(81;0.00116)|all_epithelial(167;0.000761)|all_lung(203;0.00277)|Lung NSC(277;0.0043)		Lung(183;0.0236)|Colorectal(144;0.0286)|all cancers(265;0.0572)|Epithelial(280;0.0862)|COAD - Colon adenocarcinoma(174;0.112)|LUSC - Lung squamous cell carcinoma(189;0.134)		CAAACTCTCAGAAGAAAAGAG	0.433000													67	339					0	0	1	0	0
DNAH9	1770	broad.mit.edu	37	17	11650939	11650939	+	Missense_Mutation	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr17:11650939G>A	ENST00000262442.3	+	32	6534	c.6466G>A	c.(6466-6468)Ggc>Agc	p.G2156S	DNAH9_ENST00000454412.2_Missense_Mutation_p.G2156S	NM_001372.3	NP_001363.2	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9	2156	AAA 2 (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			NS(2)|autonomic_ganglia(1)|breast(15)|central_nervous_system(5)|endometrium(17)|haematopoietic_and_lymphoid_tissue(6)|kidney(17)|large_intestine(49)|liver(2)|lung(123)|ovary(6)|pancreas(1)|prostate(6)|skin(21)|stomach(2)|upper_aerodigestive_tract(13)|urinary_tract(4)	290		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		CGCTGGTACCGGCAAGTCACA	0.572000													43	334					0	0	1	0	0
SPATA2L	124044	broad.mit.edu	37	16	89764126	89764126	+	Silent	SNP	C	C	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr16:89764126C>T	ENST00000289805.5	-	3	959	c.891G>A	c.(889-891)gaG>gaA	p.E297E	SPATA2L_ENST00000335360.7_Intron	NM_152339.3	NP_689552.2	Q8IUW3	SPA2L_HUMAN	spermatogenesis associated 2-like	297										breast(1)|cervix(1)|endometrium(1)|lung(2)|skin(1)	6		Lung NSC(15;0.00043)|all_lung(18;0.000665)|all_hematologic(23;0.0355)		BRCA - Breast invasive adenocarcinoma(80;0.0272)		CCAGCCCCTCCTCCAAGGCCC	0.682000													15	104					0	0	1	0	0
LSM14A	26065	broad.mit.edu	37	19	34685499	34685499	+	Missense_Mutation	SNP	C	C	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr19:34685499C>T	ENST00000544216.3	+	2	315	c.238C>T	c.(238-240)Cca>Tca	p.P80S	LSM14A_ENST00000540746.2_Missense_Mutation_p.P80S|LSM14A_ENST00000433627.5_Missense_Mutation_p.P80S	NM_015578.2	NP_056393.2	Q8ND56	LS14A_HUMAN	LSM14A, SCD6 homolog A (S. cerevisiae)	80					cytoplasmic mRNA processing body assembly|multicellular organismal development|regulation of translation	cytoplasmic mRNA processing body|intracellular membrane-bounded organelle|stress granule				breast(1)|endometrium(4)|kidney(1)|large_intestine(8)|lung(7)|skin(1)	22	Esophageal squamous(110;0.162)					TGTTTGTGAGCCACCAAAACC	0.438000													90	611					0	0	1	0	0
MT-RNR2	0	broad.mit.edu	37	MT	1719	1719	+	RNA	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:1719G>A	ENST00000387347.2	+	0	49					NR_039705.1																						CAGACAACCTTAGCCAAACCA	0.418000													18	62					0	0	1	0	0
CLCN2	1181	broad.mit.edu	37	3	184079221	184079221	+	Missense_Mutation	SNP	T	T	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr3:184079221T>G	ENST00000265593.4	-	1	218	c.47A>C	c.(46-48)cAg>cCg	p.Q16P	CLCN2_ENST00000344937.7_Missense_Mutation_p.Q16P|CLCN2_ENST00000457512.1_Missense_Mutation_p.Q16P|CLCN2_ENST00000434054.2_Missense_Mutation_p.Q16P|EIF2B5_ENST00000444495.1_Intron|CLCN2_ENST00000423355.2_5'UTR	NM_004366.5	NP_004357.3	P51788	CLCN2_HUMAN	chloride channel, voltage-sensitive 2	16						chloride channel complex	voltage-gated chloride channel activity			breast(2)|central_nervous_system(4)|endometrium(1)|kidney(3)|large_intestine(4)|lung(9)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	27	all_cancers(143;6.66e-11)|Ovarian(172;0.0339)		Epithelial(37;2.22e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)		Lubiprostone(DB01046)	CTGCTCGTACTGCAGCGCCCG	0.706000													44	298					0	0	1	0	0
MT-ATP6	4508	broad.mit.edu	37	MT	8697	8697	+	Missense_Mutation	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:8697G>A	ENST00000361899.2	+	1	171	c.171G>A	c.(169-171)atG>atA	p.M57I						mitochondrially encoded ATP synthase 6											breast(2)|endometrium(7)|kidney(8)|prostate(1)	18						TCAAAACAAATGATAGCCATA	0.403000													24	83					0	0	1	0	0
MT-CO3	4514	broad.mit.edu	37	MT	9540	9540	+	Missense_Mutation	SNP	T	T	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:9540T>C	ENST00000362079.2	+	1	334	c.334T>C	c.(334-336)Tta>Cta	p.112_112insL						mitochondrially encoded cytochrome c oxidase III											breast(1)|endometrium(10)|kidney(14)|lung(1)|urinary_tract(1)	27						CTACCCCCCAACTAGGAGGGC	0.493000													6	80					0	0	1	0	0
NOL6	65083	broad.mit.edu	37	9	33468069	33468069	+	Missense_Mutation	SNP	C	C	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr9:33468069C>T	ENST00000379471.2	-	11	1470	c.1383G>A	c.(1381-1383)atG>atA	p.M461I	NOL6_ENST00000455041.2_Missense_Mutation_p.M409I|NOL6_ENST00000464829.1_Intron			Q9H6R4	NOL6_HUMAN	nucleolar protein 6 (RNA-associated)	461					rRNA processing	condensed nuclear chromosome|nucleolus	RNA binding			endometrium(4)|kidney(4)|large_intestine(5)|lung(8)|ovary(2)|prostate(2)|skin(2)	27			LUSC - Lung squamous cell carcinoma(29;0.00788)	GBM - Glioblastoma multiforme(74;0.152)		GTTTGGGAGTCATCAACAGCA	0.567000													29	590					0	0	1	0	0
SLC2A13	114134	broad.mit.edu	37	12	40499348	40499348	+	Missense_Mutation	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr12:40499348G>A	ENST00000280871.4	-	1	313	c.263C>T	c.(262-264)tCc>tTc	p.S88F	SLC2A13_ENST00000380858.1_Missense_Mutation_p.S88F	NM_052885.3	NP_443117.3	Q96QE2	MYCT_HUMAN	solute carrier family 2 (facilitated glucose transporter), member 13	88						integral to membrane|plasma membrane	myo-inositol:hydrogen symporter activity			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(12)|ovary(1)|prostate(1)|upper_aerodigestive_tract(4)|urinary_tract(1)	29		Lung NSC(34;0.105)|all_lung(34;0.123)				GCCCAGCGCGGAGAAGACGGC	0.721000										HNSCC(50;0.14)			6	34					0	0	1	0	0
CD58	965	broad.mit.edu	37	1	117087113	117087113	+	Missense_Mutation	SNP	T	T	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr1:117087113T>C	ENST00000457047.2	-	2	237	c.184A>G	c.(184-186)Aaa>Gaa	p.K62E	CD58_ENST00000369487.3_Missense_Mutation_p.K62E|CD58_ENST00000369489.5_Missense_Mutation_p.K62E	NM_001144822.1	NP_001138294.1	P19256	LFA3_HUMAN	CD58 molecule	62					blood coagulation|cell-cell adhesion|leukocyte migration	anchored to membrane|integral to plasma membrane	protein binding			endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(3)|urinary_tract(1)	9	Lung SC(450;0.225)	all_cancers(81;0.000363)|all_lung(203;0.000118)|all_epithelial(167;0.000149)|Lung NSC(69;0.000577)		Lung(183;0.0086)|LUSC - Lung squamous cell carcinoma(189;0.0528)|Colorectal(144;0.0775)|all cancers(265;0.109)|Epithelial(280;0.118)|COAD - Colon adenocarcinoma(174;0.121)		TCTGCAACTTTATCCTTTTGT	0.348000													38	168					0	0	1	0	0
RFX3	5991	broad.mit.edu	37	9	3271027	3271027	+	Missense_Mutation	SNP	T	T	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr9:3271027T>C	ENST00000382004.3	-	11	1489	c.1178A>G	c.(1177-1179)gAt>gGt	p.D393G	RFX3_ENST00000358730.2_Missense_Mutation_p.D393G|RFX3_ENST00000302303.1_Missense_Mutation_p.D393G	NM_134428.1	NP_602304.1	P48380	RFX3_HUMAN	regulatory factor X, 3 (influences HLA class II expression)	393					cell maturation|ciliary cell motility|cilium assembly|cilium movement involved in determination of left/right asymmetry|endocrine pancreas development|negative regulation of transcription, DNA-dependent|positive regulation of transcription from RNA polymerase II promoter|positive regulation of type B pancreatic cell development|regulation of insulin secretion	nuclear chromatin	protein binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription regulatory region DNA binding			central_nervous_system(1)|cervix(2)|endometrium(2)|kidney(11)|large_intestine(3)|lung(14)|ovary(2)|pancreas(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	40				GBM - Glioblastoma multiforme(50;0.00124)|Lung(2;0.0337)		GGTAGTGCCATCAGTTGGAGT	0.368000													48	362					0	0	1	0	0
MT-ATP6	4508	broad.mit.edu	37	MT	9080	9080	+	Missense_Mutation	SNP	A	A	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:9080A>G	ENST00000361899.2	+	1	554	c.554A>G	c.(553-555)aAc>aGc	p.N185S						mitochondrially encoded ATP synthase 6											breast(2)|endometrium(7)|kidney(8)|prostate(1)	18						ATCAACCATTAACCTTCCCTC	0.453000													4	60					0	0	1	0	0
MT-CYB	4519	broad.mit.edu	37	MT	15043	15043	+	Missense_Mutation	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:15043G>A	ENST00000361789.2	+	1	297	c.297G>A	c.(295-297)ggG>ggA	p.99_99insG						mitochondrially encoded cytochrome b											breast(6)|endometrium(25)|kidney(33)|prostate(1)	65						CTACACATCGGGCGAGGCCTA	0.468000													4	38					0	0	1	0	0
NCAM1	4684	broad.mit.edu	37	11	113105776	113105776	+	Missense_Mutation	SNP	C	C	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr11:113105776C>A	ENST00000316851.7	+	13	1685	c.1685C>A	c.(1684-1686)aCc>aAc	p.T562N	NCAM1_ENST00000397957.4_3'UTR|NCAM1_ENST00000401611.2_Missense_Mutation_p.T571N|NCAM1_ENST00000533760.1_Missense_Mutation_p.T444N	NM_001242607.1|NM_181351.4	NP_001229536.1|NP_851996.2	P13591	NCAM1_HUMAN	neural cell adhesion molecule 1	572	Fibronectin type-III 1.				axon guidance|interferon-gamma-mediated signaling pathway	anchored to membrane|extracellular region|Golgi membrane|integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		GGCATCGTCACCATCGTGGGC	0.547000													10	35					0.000442599	0.000447535	1	1	0
MYO3B	140469	broad.mit.edu	37	2	171323216	171323216	+	Silent	SNP	G	G	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr2:171323216G>C	ENST00000334231.6	+	25	3036	c.3036G>C	c.(3034-3036)gtG>gtC	p.V1012V	MYO3B_ENST00000408978.4_Silent_p.V1003V|MYO3B_ENST00000602629.1_Intron|MYO3B_ENST00000409044.3_Silent_p.V1003V			Q8WXR4	MYO3B_HUMAN	myosin IIIB	1003	Myosin head-like.				response to stimulus|visual perception	cytoplasm|myosin complex	actin binding|ATP binding|motor activity|protein serine/threonine kinase activity			breast(1)|central_nervous_system(3)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(9)|lung(25)|ovary(6)|pancreas(1)|prostate(1)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	59						AAGAATTTGTGAAAAGGTCAG	0.532000													59	385					0	0	1	0	0
NFKBIA	4792	broad.mit.edu	37	14	35873637	35873637	+	Missense_Mutation	SNP	C	C	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr14:35873637C>G	ENST00000216797.5	-	1	315	c.214G>C	c.(214-216)Gag>Cag	p.E72Q	NFKBIA_ENST00000557140.1_Missense_Mutation_p.E72Q|NFKBIA_ENST00000557100.1_5'UTR	NM_020529.2	NP_065390.1	P25963	IKBA_HUMAN	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	72					anti-apoptosis|apoptosis|cellular response to cold|cytoplasmic sequestering of NF-kappaB|innate immune response|interspecies interaction between organisms|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of DNA binding|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|negative regulation of NF-kappaB transcription factor activity|nerve growth factor receptor signaling pathway|positive regulation of cellular protein metabolic process|positive regulation of cholesterol efflux|positive regulation of NF-kappaB transcription factor activity|positive regulation of transcription from RNA polymerase II promoter|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|I-kappaB/NF-kappaB complex|nucleus|plasma membrane	identical protein binding|NF-kappaB binding|nuclear localization sequence binding|ubiquitin protein ligase binding			breast(3)|endometrium(1)|large_intestine(2)|liver(1)	7	Breast(36;0.0484)|Hepatocellular(127;0.158)		Lung(238;9.25e-06)|LUAD - Lung adenocarcinoma(48;1.53e-05)|Epithelial(34;0.00314)|all cancers(34;0.00891)	GBM - Glioblastoma multiforme(112;0.0222)		TCCCCGTCCTCGGTGAGCTGC	0.741000													11	71					0	0	1	0	0
PIGO	84720	broad.mit.edu	37	9	35095294	35095294	+	Missense_Mutation	SNP	A	A	T	rs148704151		TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr9:35095294A>T	ENST00000378617.3	-	2	663	c.269T>A	c.(268-270)gTg>gAg	p.V90E	PIGO_ENST00000298004.5_Missense_Mutation_p.V90E|PIGO_ENST00000492770.1_5'UTR|PIGO_ENST00000361778.2_Missense_Mutation_p.V90E|PIGO_ENST00000341666.3_Missense_Mutation_p.V90E	NM_032634.3	NP_116023.2	Q8TEQ8	PIGO_HUMAN	phosphatidylinositol glycan anchor biosynthesis, class O	90					C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane	transferase activity			endometrium(3)|kidney(2)|large_intestine(8)|lung(13)|ovary(3)|prostate(2)|skin(3)|stomach(1)|upper_aerodigestive_tract(3)	38			LUSC - Lung squamous cell carcinoma(32;0.00343)|Lung(28;0.00778)			CTCTCTAGGCACGTGTGAATG	0.577000													48	717					0	0	1	0	0
ZNF556	80032	broad.mit.edu	37	19	2877458	2877458	+	Missense_Mutation	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr19:2877458G>A	ENST00000586426.1	+	4	586	c.499G>A	c.(499-501)Gct>Act	p.A167T	ZNF556_ENST00000307635.2_Missense_Mutation_p.A168T			Q9HAH1	ZN556_HUMAN	zinc finger protein 556	168					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(2)|kidney(1)|large_intestine(7)|lung(10)|pancreas(1)|prostate(3)|skin(7)	31				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCACAAAAGAGCTCACTCTGG	0.438000													87	440					0	0	1	0	0
PTDSS1	9791	broad.mit.edu	37	8	97311970	97311970	+	Missense_Mutation	SNP	C	C	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr8:97311970C>G	ENST00000517309.1	+	6	975	c.649C>G	c.(649-651)Caa>Gaa	p.Q217E	PTDSS1_ENST00000455950.2_Missense_Mutation_p.Q71E|PTDSS1_ENST00000518776.1_3'UTR|PTDSS1_ENST00000522072.1_Missense_Mutation_p.Q14E	NM_014754.1	NP_055569.1	P48651	PTSS1_HUMAN	phosphatidylserine synthase 1	217					phosphatidylserine biosynthetic process	integral to membrane	transferase activity			endometrium(2)|kidney(2)|large_intestine(8)|lung(14)|ovary(1)|prostate(1)|stomach(1)	29	Breast(36;6.18e-05)				Phosphatidylserine(DB00144)	CTGGTGGGATCAAGTCATTCT	0.493000													64	841					0	0	1	0	0
TAMM41	132001	broad.mit.edu	37	3	11851103	11851103	+	Silent	SNP	G	G	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr3:11851103G>C	ENST00000444133.2	-	6	904	c.762C>G	c.(760-762)acC>acG	p.T254T	TAMM41_ENST00000455809.1_Silent_p.T254T|TAMM41_ENST00000273037.5_Silent_p.T254T			Q96BW9	MMP37_HUMAN	TAM41, mitochondrial translocator assembly and maintenance protein, homolog (S. cerevisiae)	254					protein import into mitochondrial matrix	extrinsic to mitochondrial inner membrane											GTTGCTGTAAGGTTTTGGGCA	0.418000													39	457					0	0	1	0	0
MT-RNR2	0	broad.mit.edu	37	MT	1736	1736	+	RNA	SNP	A	A	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:1736A>G	ENST00000387347.2	+	0	66					NR_039705.1																						ACCATTTACCCAAATAAAGTA	0.403000													19	68					0	0	1	0	0
VPS13B	157680	broad.mit.edu	37	8	100155279	100155279	+	Missense_Mutation	SNP	C	C	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr8:100155279C>G	ENST00000395996.1	+	13	1840	c.1729C>G	c.(1729-1731)Ctt>Gtt	p.L577V	VPS13B_ENST00000357162.2_Missense_Mutation_p.L577V|VPS13B_ENST00000358544.2_Missense_Mutation_p.L577V|VPS13B_ENST00000355155.1_Missense_Mutation_p.L577V			Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13 homolog B (yeast)	577					protein transport					NS(1)|autonomic_ganglia(1)|breast(6)|central_nervous_system(4)|cervix(3)|endometrium(11)|haematopoietic_and_lymphoid_tissue(4)|kidney(10)|large_intestine(37)|lung(78)|ovary(8)|pancreas(3)|prostate(5)|skin(9)|upper_aerodigestive_tract(4)|urinary_tract(9)	193	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CACCAAAAGCCTTGTTATAGG	0.373000													143	335					0	0	1	0	0
MT-CO3	4514	broad.mit.edu	37	MT	9656	9656	+	Missense_Mutation	SNP	T	T	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:9656T>C	ENST00000362079.2	+	1	450	c.450T>C	c.(448-450)agT>agC	p.150_150insS						mitochondrially encoded cytochrome c oxidase III											breast(1)|endometrium(10)|kidney(14)|lung(1)|urinary_tract(1)	27						GCTCACCATAGTCTAATAGAA	0.443000													7	105					0	0	1	0	0
OR1J2	26740	broad.mit.edu	37	9	125273681	125273681	+	Missense_Mutation	SNP	A	A	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr9:125273681A>G	ENST00000335302.5	+	1	601	c.601A>G	c.(601-603)Aca>Gca	p.T201A		NM_054107.1	NP_473448.1	Q8NGS2	OR1J2_HUMAN	olfactory receptor, family 1, subfamily J, member 2	201					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(3)|lung(8)|pancreas(1)|skin(7)|stomach(1)	26						GGTCATGTTCACAGTAGGGGT	0.517000													74	330					0	0	1	0	0
FNBP1	23048	broad.mit.edu	37	9	132662705	132662705	+	Splice_Site	SNP	C	C	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr9:132662705C>T	ENST00000420781.1	-	14	1741	c.1523_splice	c.e14+1	p.S508_splice	FNBP1_ENST00000355681.3_Splice_Site_p.S488_splice|FNBP1_ENST00000446176.2_Splice_Site_p.S517_splice|FNBP1_ENST00000478129.1_5'UTR|FNBP1_ENST00000443566.2_Splice_Site_p.S145_splice			Q96RU3	FNBP1_HUMAN	formin binding protein 1	517	Interaction with PDE6G (By similarity).|Interaction with RND2 (By similarity).|Required for self-association and induction of membrane tubulation.				endocytosis	cell cortex|cytoplasmic membrane-bounded vesicle|cytoskeleton|lysosome|plasma membrane	identical protein binding|lipid binding						Ovarian(14;0.000536)		GBM - Glioblastoma multiforme(294;0.0378)		GATACTGTACCTCTCACGGTC	0.572000			T	MLL	AML								9	73					0	0	1	0	0
CTD-2066L21.3	0	broad.mit.edu	37	5	33162639	33162639	+	RNA	SNP	T	T	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr5:33162639T>C	ENST00000510327.1	-	0	346																											TCCCACTACGTGCTGCCCCTG	0.463000													9	157					0	0	1	0	0
GLI3	2737	broad.mit.edu	37	7	42012195	42012195	+	Missense_Mutation	SNP	G	G	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr7:42012195G>C	ENST00000395925.3	-	13	1928	c.1844C>G	c.(1843-1845)aCt>aGt	p.T615S	GLI3_ENST00000479210.1_5'UTR	NM_000168.5	NP_000159.3	P10071	GLI3_HUMAN	GLI family zinc finger 3	615					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			NS(2)|biliary_tract(1)|breast(4)|central_nervous_system(2)|endometrium(12)|kidney(7)|large_intestine(25)|lung(49)|ovary(3)|pancreas(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	112						GTAACGCTTAGTGCAGCCTGG	0.507000									Pallister-Hall syndrome;Greig Cephalopolysyndactyly				40	226					0	0	1	0	0
MT-CO1	4512	broad.mit.edu	37	MT	6293	6293	+	Missense_Mutation	SNP	T	T	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:6293T>C	ENST00000361624.2	+	1	390	c.390T>C	c.(388-390)ccT>ccC	p.130_130insP						mitochondrially encoded cytochrome c oxidase I											breast(4)|endometrium(25)|kidney(19)|lung(3)|prostate(3)	54						ACAGTCTACCCTCCCTTAGCA	0.517000													23	118					0	0	1	0	0
KIAA1467	57613	broad.mit.edu	37	12	13219646	13219646	+	Missense_Mutation	SNP	G	G	A	rs145573782	by1000genomes	TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr12:13219646G>A	ENST00000197268.8	+	6	1045	c.925G>A	c.(925-927)Gtt>Att	p.V309I		NM_020853.1	NP_065904.1	A2RU67	K1467_HUMAN	KIAA1467	309						integral to membrane				NS(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|lung(13)|ovary(1)|prostate(1)|skin(4)	36		Prostate(47;0.184)		BRCA - Breast invasive adenocarcinoma(232;0.157)		GTACAACATCGTTGGAGTTGG	0.507000													18	399					0	0	1	0	0
MT-ND4	4538	broad.mit.edu	37	MT	11251	11251	+	Missense_Mutation	SNP	A	A	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:11251A>G	ENST00000361381.2	+	1	492	c.492A>G	c.(490-492)ctA>ctG	p.164_164insL						mitochondrially encoded NADH dehydrogenase 4											breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|prostate(1)	13						CTCATCGCACTAATTTACACT	0.473000													17	70					0	0	1	0	0
FRYL	285527	broad.mit.edu	37	4	48605373	48605373	+	Missense_Mutation	SNP	C	C	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr4:48605373C>G	ENST00000358350.4	-	12	1471	c.867G>C	c.(865-867)ttG>ttC	p.L289F	FRYL_ENST00000507711.1_Missense_Mutation_p.L289F|FRYL_ENST00000264319.7_5'UTR|FRYL_ENST00000506685.1_5'UTR|FRYL_ENST00000503238.1_Missense_Mutation_p.L289F|FRYL_ENST00000537810.1_Missense_Mutation_p.L289F	NM_015030.1	NP_055845.1	O94915	FRYL_HUMAN	FRY-like	289					regulation of transcription, DNA-dependent|transcription, DNA-dependent		protein binding			breast(2)|central_nervous_system(2)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(21)|lung(38)|ovary(1)|pancreas(1)|prostate(3)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	91						CAAAATTTTTCAAACAGGGAA	0.289000													46	318					0	0	1	0	0
NOS2	4843	broad.mit.edu	37	17	26108128	26108128	+	Silent	SNP	G	G	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr17:26108128G>T	ENST00000313735.6	-	8	1031	c.798C>A	c.(796-798)cgC>cgA	p.R266R		NM_000625.4	NP_000616.3	P35228	NOS2_HUMAN	nitric oxide synthase 2, inducible	266				R -> H (in Ref. 8; AAC19133).	arginine catabolic process|defense response to Gram-negative bacterium|innate immune response in mucosa|nitric oxide biosynthetic process|peptidyl-cysteine S-nitrosylation|platelet activation|positive regulation of killing of cells of other organism|positive regulation of leukocyte mediated cytotoxicity|regulation of cellular respiration|regulation of insulin secretion|superoxide metabolic process	cytosol|nucleus	arginine binding|calmodulin binding|flavin adenine dinucleotide binding|FMN binding|heme binding|NADP binding|nitric-oxide synthase activity|protein homodimerization activity|tetrahydrobiopterin binding			autonomic_ganglia(1)|breast(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(8)|lung(28)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	56					Dexamethasone(DB01234)|Hydrocortisone(DB00741)|L-Arginine(DB00125)|L-Citrulline(DB00155)	AGCCAGCATAGCGGATGAGCT	0.612000													13	406					1.05317e-09	1.08508e-09	1	1	0
KRT39	390792	broad.mit.edu	37	17	39114945	39114945	+	Missense_Mutation	SNP	A	A	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr17:39114945A>G	ENST00000355612.2	-	7	1419	c.1384T>C	c.(1384-1386)Tgc>Cgc	p.C462R	AC004231.2_ENST00000418393.1_RNA	NM_213656.3	NP_998821.3	Q6A163	K1C39_HUMAN	keratin 39	462	Tail.					intermediate filament	structural molecule activity			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(8)|upper_aerodigestive_tract(1)	17		Breast(137;0.00043)|Ovarian(249;0.15)				GTGATGGTGCAAATTTTAACC	0.507000													16	513					0	0	1	0	0
HBE1	3046	broad.mit.edu	37	11	5289744	5289744	+	Missense_Mutation	SNP	C	C	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr11:5289744C>G	ENST00000380237.1	-	5	743	c.399G>C	c.(397-399)aaG>aaC	p.K133N	HBE1_ENST00000292896.2_Missense_Mutation_p.K133N|HBG2_ENST00000380252.1_Intron|HBG2_ENST00000380259.2_Intron			P02100	HBE_HUMAN	hemoglobin, epsilon 1	133					blood coagulation	hemoglobin complex	heme binding|oxygen binding|oxygen transporter activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(12)|skin(1)	20		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;1.34e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		CAGACACCAGCTTCTGCCAGG	0.532000													109	531					0	0	1	0	0
WDR45	11152	broad.mit.edu	37	X	48932560	48932560	+	Missense_Mutation	SNP	C	C	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrX:48932560C>G	ENST00000356463.3	-	12	1426	c.988G>C	c.(988-990)Gat>Cat	p.D330H	WDR45_ENST00000396681.4_Missense_Mutation_p.D315H|WDR45_ENST00000376358.3_Intron|WDR45_ENST00000376368.2_Missense_Mutation_p.D330H|WDR45_ENST00000376372.3_Missense_Mutation_p.D329H|WDR45_ENST00000322995.8_Missense_Mutation_p.D340H|WDR45_ENST00000485908.1_Missense_Mutation_p.D294H|WDR45_ENST00000473974.1_Missense_Mutation_p.R246T|WDR45_ENST00000470270.1_Intron|WDR45_ENST00000553851.1_Intron	NM_007075.3	NP_009006.2	Q9Y484	WIPI4_HUMAN	WD repeat domain 45	329					autophagy|response to starvation	organelle membrane	phosphatidylinositol-3,5-bisphosphate binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|ovary(1)|skin(1)	19						AAGGTCCCATCTACGCAGATG	0.537000													18	278					0	0	1	0	0
EOMES	8320	broad.mit.edu	37	3	27759190	27759190	+	Nonsense_Mutation	SNP	C	C	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr3:27759190C>A	ENST00000295743.4	-	6	1635	c.1432G>T	c.(1432-1434)Gag>Tag	p.E478*	EOMES_ENST00000537516.1_Nonsense_Mutation_p.E202*|EOMES_ENST00000449599.1_Nonsense_Mutation_p.E497*			O95936	EOMES_HUMAN	eomesodermin	478					CD8-positive, alpha-beta T cell differentiation involved in immune response|cell differentiation involved in embryonic placenta development|endoderm formation|mesoderm formation|mesodermal to mesenchymal transition involved in gastrulation|positive regulation of transcription, DNA-dependent	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)|endometrium(1)|kidney(1)|large_intestine(6)|lung(7)|ovary(3)|prostate(1)	21						ACAAAGGGCTCCGGGAAGAAG	0.527000													40	435					1.96642e-18	2.09751e-18	1	1	0
CACNA1C	775	broad.mit.edu	37	12	2760901	2760901	+	Silent	SNP	G	G	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr12:2760901G>C	ENST00000399655.1	+	32	4306	c.4041G>C	c.(4039-4041)cgG>cgC	p.R1347R	CACNA1C_ENST00000399621.1_Silent_p.R1347R|CACNA1C_ENST00000399591.1_Silent_p.R1336R|CACNA1C_ENST00000344100.3_Silent_p.R1369R|CACNA1C_ENST00000399637.1_Silent_p.R1347R|CACNA1C_ENST00000399595.1_Silent_p.R1336R|CACNA1C_ENST00000399617.1_Silent_p.R1347R|CACNA1C_ENST00000399597.1_Silent_p.R1347R|CACNA1C_ENST00000399649.1_Silent_p.R1334R|CACNA1C_ENST00000347598.4_Silent_p.R1395R|CACNA1C_ENST00000399606.1_Silent_p.R1367R|CACNA1C_ENST00000399634.1_Silent_p.R1347R|CACNA1C_ENST00000399641.1_Silent_p.R1347R|CACNA1C_ENST00000402845.3_Silent_p.R1347R|CACNA1C_ENST00000327702.7_Silent_p.R1347R|CACNA1C_ENST00000399629.1_Silent_p.R1364R|CACNA1C_ENST00000399601.1_Silent_p.R1347R|CACNA1C_ENST00000335762.5_Silent_p.R1372R|CACNA1C_ENST00000399644.1_Silent_p.R1347R|CACNA1C_ENST00000399638.1_Silent_p.R1375R|CACNA1C_ENST00000399603.1_Silent_p.R1347R|CACNA1C_ENST00000406454.3_Silent_p.R1347R	NM_000719.6|NM_001129829.1|NM_001129834.1	NP_000710.5|NP_001123301.1|NP_001123306.1	Q13936	CAC1C_HUMAN	calcium channel, voltage-dependent, L type, alpha 1C subunit	1395					axon guidance|calcium ion transport into cytosol|energy reserve metabolic process|regulation of insulin secretion	cytoplasm|postsynaptic density|voltage-gated calcium channel complex	calmodulin binding|voltage-gated calcium channel activity			NS(3)|breast(4)|central_nervous_system(4)|cervix(2)|endometrium(12)|kidney(9)|large_intestine(20)|lung(55)|ovary(10)|pancreas(1)|prostate(5)|skin(3)|upper_aerodigestive_tract(4)	132			OV - Ovarian serous cystadenocarcinoma(31;0.00256)	LUAD - Lung adenocarcinoma(1;0.134)	Ibutilide(DB00308)|Isradipine(DB00270)|Magnesium Sulfate(DB00653)|Mibefradil(DB01388)|Nicardipine(DB00622)|Verapamil(DB00661)	AGGGCATCCGGACGCTGCTGT	0.637000													39	205					0	0	1	0	0
MYO9B	4650	broad.mit.edu	37	19	17311139	17311139	+	Missense_Mutation	SNP	G	G	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr19:17311139G>C	ENST00000595618.1	+	25	4428	c.4276G>C	c.(4276-4278)Gat>Cat	p.D1426H	MYO9B_ENST00000594824.1_Missense_Mutation_p.D1426H|MYO9B_ENST00000397274.2_Missense_Mutation_p.D1426H	NM_001130065.1|NM_004145.3	NP_001123537.1|NP_004136.2	Q13459	MYO9B_HUMAN	myosin IXB	1426	Tail.				actin filament-based movement	cell cortex|cytosol|filamentous actin|myosin complex|perinuclear region of cytoplasm	actin binding|ADP binding|ATP binding|ATPase activity|calmodulin binding|metal ion binding|microfilament motor activity|Rho GTPase activator activity			breast(3)|endometrium(9)|kidney(2)|large_intestine(1)|lung(19)|soft_tissue(1)|urinary_tract(4)	39						TAAAACCAAGGATAAAAAATA	0.507000													9	105					0	0	1	0	0
MT-CO1	4512	broad.mit.edu	37	MT	6249	6249	+	Missense_Mutation	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:6249G>A	ENST00000361624.2	+	1	346	c.346G>A	c.(346-348)Gct>Act	p.116_116insT						mitochondrially encoded cytochrome c oxidase I											breast(4)|endometrium(25)|kidney(19)|lung(3)|prostate(3)	54						TGCTCGCATCTGCTATAGTGG	0.532000													7	109					0	0	1	0	0
PDE8B	8622	broad.mit.edu	37	5	76507011	76507011	+	Silent	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr5:76507011G>A	ENST00000264917.5	+	1	306	c.261G>A	c.(259-261)gcG>gcA	p.A87A	PDE8B_ENST00000340978.3_Silent_p.A87A|PDE8B_ENST00000346042.3_Silent_p.A87A|PDE8B_ENST00000342343.4_Silent_p.A87A|PDE8B_ENST00000333194.4_Silent_p.A87A	NM_003719.3	NP_003710.1	O95263	PDE8B_HUMAN	phosphodiesterase 8B	87					cyclic nucleotide metabolic process|regulation of transcription, DNA-dependent	cytosol	3',5'-cyclic-AMP phosphodiesterase activity|metal ion binding|two-component response regulator activity		GMDS/PDE8B(2)	NS(1)|autonomic_ganglia(2)|breast(1)|central_nervous_system(1)|endometrium(4)|large_intestine(10)|lung(15)|ovary(1)|prostate(2)|skin(3)	40		all_lung(232;0.00043)|Lung NSC(167;0.00114)|Ovarian(174;0.0107)|Prostate(461;0.0605)		OV - Ovarian serous cystadenocarcinoma(54;2.21e-49)|Epithelial(54;5.82e-43)|all cancers(79;4.06e-38)		CCCCCGCCGCGACCACCAGCA	0.751000													7	10					0	0	1	0	0
MT-ND4	4538	broad.mit.edu	37	MT	10873	10873	+	Missense_Mutation	SNP	T	T	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:10873T>C	ENST00000361381.2	+	1	114	c.114T>C	c.(112-114)ccT>ccC	p.38_38insP						mitochondrially encoded NADH dehydrogenase 4											breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|prostate(1)	13						AGCATCATCCCCCTACTATTT	0.403000													10	62					0	0	1	0	0
TAOK1	57551	broad.mit.edu	37	17	27857472	27857472	+	Silent	SNP	C	C	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr17:27857472C>T	ENST00000261716.3	+	18	2715	c.2196C>T	c.(2194-2196)atC>atT	p.I732I	TAOK1_ENST00000536202.1_Silent_p.I584I	NM_020791.2	NP_065842.1	Q7L7X3	TAOK1_HUMAN	TAO kinase 1	732					mitotic prometaphase	cytosol|intracellular membrane-bounded organelle	ATP binding|protein serine/threonine kinase activity			NS(1)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(1)|large_intestine(4)|lung(14)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	28			Colorectal(6;0.198)			CCTGCAAAATCCAAACCAGAC	0.393000													27	198					0	0	1	0	0
GLOD5	392465	broad.mit.edu	37	X	48624245	48624245	+	Missense_Mutation	SNP	G	G	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrX:48624245G>T	ENST00000303227.6	+	2	110	c.69G>T	c.(67-69)tgG>tgT	p.W23C	GLOD5_ENST00000470676.1_3'UTR	NM_001080489.2	NP_001073958.2			glyoxalase domain containing 5											endometrium(1)|lung(2)	3						TTTAGTCATGGAGGGACAGCA	0.473000													5	65					1	1	1	1	0
MT-ND6	4541	broad.mit.edu	37	MT	14233	14233	+	Silent	SNP	A	A	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:14233A>G	ENST00000361681.2	-	1	440	c.441T>C	c.(439-441)gaT>gaC	p.D147D						mitochondrially encoded NADH dehydrogenase 6											breast(1)|endometrium(10)|kidney(17)|urinary_tract(1)	29						CAACGCCCATAATCATACAAA	0.408000													7	35					0	0	1	0	0
TMOD1	7111	broad.mit.edu	37	9	100328234	100328234	+	Silent	SNP	G	G	A	rs142987399		TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr9:100328234G>A	ENST00000395211.2	+	7	859	c.723G>A	c.(721-723)gcG>gcA	p.A241A	TMOD1_ENST00000259365.3_Silent_p.A241A|TMOD1_ENST00000375175.1_Silent_p.A114A	NM_001166116.1	NP_001159588.1	P28289	TMOD1_HUMAN	tropomodulin 1	241					muscle filament sliding	cytosol	actin binding			breast(1)|central_nervous_system(1)|kidney(3)|large_intestine(3)|lung(2)|urinary_tract(1)	11		Acute lymphoblastic leukemia(62;0.154)		STAD - Stomach adenocarcinoma(157;0.105)		ACCCCGTGGCGTATGTATGTA	0.493000													59	300					0	0	1	0	0
FLT4	2324	broad.mit.edu	37	5	180056837	180056837	+	Splice_Site	SNP	T	T	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr5:180056837T>A	ENST00000261937.6	-	6	755		c.e6-2		FLT4_ENST00000424276.2_Splice_Site|FLT4_ENST00000502649.1_Splice_Site|FLT4_ENST00000393347.3_Splice_Site	NM_182925.4	NP_891555.2	P35916	VGFR3_HUMAN	fms-related tyrosine kinase 4						positive regulation of cell proliferation	integral to plasma membrane	ATP binding|protein phosphatase binding|vascular endothelial growth factor receptor activity			NS(1)|breast(3)|central_nervous_system(2)|endometrium(1)|kidney(6)|large_intestine(5)|liver(2)|lung(37)|ovary(6)|prostate(1)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	71	all_cancers(89;2.21e-05)|all_epithelial(37;5.29e-06)|Renal(175;0.000159)|Lung NSC(126;0.00199)|all_lung(126;0.00351)|Breast(19;0.114)	all_cancers(40;0.00245)|Medulloblastoma(196;0.0133)|all_neural(177;0.0199)|all_hematologic(541;0.163)|Ovarian(839;0.238)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.134)	Sorafenib(DB00398)|Sunitinib(DB01268)	GCTCGTTGCCTGTTGACACGC	0.607000													70	93					0	0	1	0	0
TRMT61A	115708	broad.mit.edu	37	14	103996579	103996579	+	Silent	SNP	C	C	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr14:103996579C>T	ENST00000389749.4	+	2	371	c.264C>T	c.(262-264)taC>taT	p.Y88Y		NM_152307.2	NP_689520.2	Q96FX7	TRM61_HUMAN	tRNA methyltransferase 61 homolog A (S. cerevisiae)	88						nucleus	protein binding|tRNA (adenine-N1-)-methyltransferase activity			skin(1)	1						AGATCCTCTACTCCACAGACA	0.622000													91	444					0	0	1	0	0
KMT2A	4297	broad.mit.edu	37	11	118375783	118375783	+	Missense_Mutation	SNP	C	C	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr11:118375783C>T	ENST00000534358.1	+	27	9199	c.9176C>T	c.(9175-9177)cCg>cTg	p.P3059L	KMT2A_ENST00000389506.5_Missense_Mutation_p.P3056L|KMT2A_ENST00000354520.4_Missense_Mutation_p.P3018L	NM_001197104.1|NM_005933.3	NP_001184033.1|NP_005924.2			lysine (K)-specific methyltransferase 2A																		AGTCCTGGCCCGTCTCAGATT	0.507000													30	753					0	0	1	0	0
LSS	4047	broad.mit.edu	37	21	47614458	47614458	+	Silent	SNP	G	G	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr21:47614458G>T	ENST00000397728.3	-	20	2013	c.1935C>A	c.(1933-1935)gcC>gcA	p.A645A	LSS_ENST00000522411.1_Silent_p.A634A|LSS_ENST00000356396.4_Silent_p.A645A|LSS_ENST00000457828.2_Silent_p.A565A	NM_001145436.1|NM_002340.5	NP_001138908.1|NP_002331.3	P48449	ERG7_HUMAN	lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)	645					cholesterol biosynthetic process	endoplasmic reticulum membrane	lanosterol synthase activity			cervix(1)|endometrium(6)|kidney(1)|large_intestine(3)|liver(1)|lung(7)|skin(1)|urinary_tract(1)	21	Breast(49;0.214)					TCTGGGACTGGGCACTCTGCA	0.632000													41	147					4.92203e-23	5.31266e-23	1	1	0
MT-ND5	4540	broad.mit.edu	37	MT	12705	12705	+	Silent	SNP	C	C	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:12705C>T	ENST00000361567.2	+	1	369	c.369C>T	c.(367-369)atC>atT	p.I123I				P03915	NU5M_HUMAN	mitochondrially encoded NADH dehydrogenase 5	123					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(4)|endometrium(29)|kidney(33)|pancreas(1)|prostate(7)	74					NADH(DB00157)	TATCTACTCATTTTCCTAATT	0.373000													5	33					0	0	1	0	0
AGTR2	186	broad.mit.edu	37	X	115303595	115303595	+	Missense_Mutation	SNP	G	G	T	rs121917810	byFrequency	TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrX:115303595G>T	ENST00000371906.4	+	3	252	c.62G>T	c.(61-63)gGg>gTg	p.G21V		NM_000686.4	NP_000677.2	P50052	AGTR2_HUMAN	angiotensin II receptor, type 2	21					behavior|blood vessel remodeling|brain development|G-protein signaling, coupled to cGMP nucleotide second messenger|intracellular protein kinase cascade|negative regulation of blood vessel endothelial cell migration|negative regulation of cell growth|negative regulation of heart rate|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of apoptosis|positive regulation of nitric-oxide synthase activity|positive regulation of phosphoprotein phosphatase activity|positive regulation of vasodilation|regulation of systemic arterial blood pressure by circulatory renin-angiotensin		angiotensin type II receptor activity|receptor antagonist activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|skin(1)	24						CTTCACTTCGGGCTTGTGAAC	0.413000													34	228					2.42023e-17	2.5715e-17	1	1	0
DMAP1	55929	broad.mit.edu	37	1	44680376	44680376	+	Splice_Site	SNP	G	G	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr1:44680376G>C	ENST00000372289.2	+	3	462	c.197_splice	c.e3-1	p.D67_splice	DMAP1_ENST00000315913.5_Splice_Site_p.D67_splice|DMAP1_ENST00000361745.6_Splice_Site_p.D67_splice	NM_019100.4	NP_061973.1	Q9NPF5	DMAP1_HUMAN	DNA methyltransferase 1 associated protein 1	67					DNA methylation|histone H2A acetylation|histone H4 acetylation|negative regulation of transcription, DNA-dependent|regulation of growth|transcription, DNA-dependent	NuA4 histone acetyltransferase complex	DNA binding|protein binding			breast(1)|cervix(1)|endometrium(6)|large_intestine(1)|lung(4)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	16	Acute lymphoblastic leukemia(166;0.155)					CCCTGCCAGGGATGCACCCCC	0.537000													58	390					0	0	1	0	0
TAPT1-AS1	0	broad.mit.edu	37	4	16258050	16258050	+	RNA	SNP	C	C	T	rs203448	by1000genomes	TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr4:16258050C>T	ENST00000570786.1	+	0	405				TAPT1-AS1_ENST00000573308.1_RNA|TAPT1-AS1_ENST00000573950.1_RNA	NR_027696.1																						TAAACCTGCCCGTGACCTTGT	0.542000													13	216					0	0	1	0	0
TNRC18	84629	broad.mit.edu	37	7	5427483	5427483	+	Missense_Mutation	SNP	G	G	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr7:5427483G>T	ENST00000399537.4	-	5	2320	c.1972C>A	c.(1972-1974)Ccc>Acc	p.P658T	TNRC18_ENST00000430969.1_Missense_Mutation_p.P658T			O15417	TNC18_HUMAN	trinucleotide repeat containing 18	658							DNA binding	p.P658T(2)		central_nervous_system(1)|endometrium(1)|large_intestine(1)|lung(8)	11		Ovarian(82;0.142)		UCEC - Uterine corpus endometrioid carcinoma (126;0.195)|OV - Ovarian serous cystadenocarcinoma(56;5.32e-15)		GCGCTCTCGGGCCTCTCGGGG	0.736000													13	95					1.61879e-10	1.68058e-10	1	1	0
KLHL11	55175	broad.mit.edu	37	17	40010103	40010103	+	Silent	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr17:40010103G>A	ENST00000319121.3	-	2	2076	c.2016C>T	c.(2014-2016)taC>taT	p.Y672Y		NM_018143.1	NP_060613.1	Q9NVR0	KLH11_HUMAN	kelch-like family member 11	672						extracellular region				NS(2)|breast(2)|endometrium(1)|large_intestine(2)|lung(5)|ovary(2)|prostate(1)|skin(1)|urinary_tract(1)	17		Breast(137;0.00156)				GAGGCATAGGGTATCTCTGTG	0.527000													97	574					0	0	1	0	0
EDAR	10913	broad.mit.edu	37	2	109524464	109524464	+	Missense_Mutation	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr2:109524464G>A	ENST00000409271.1	-	10	1354	c.911C>T	c.(910-912)gCc>gTc	p.A304V	EDAR_ENST00000376651.1_Missense_Mutation_p.A304V|EDAR_ENST00000258443.2_Missense_Mutation_p.A272V			Q9UNE0	EDAR_HUMAN	ectodysplasin A receptor	272					apoptosis|cell differentiation	integral to membrane	protein binding|transmembrane receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(3)|lung(6)|prostate(1)|skin(1)	16						CTCGGATGAGGCATCGTTCTC	0.607000													25	173					0	0	1	0	0
RNF38	152006	broad.mit.edu	37	9	36390574	36390574	+	Translation_Start_Site	SNP	G	G	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr9:36390574G>C	ENST00000357058.3	-	0	409				RNF38_ENST00000350199.4_Intron|RNF38_ENST00000353739.4_Intron|RNF38_ENST00000377877.4_Intron|RNF38_ENST00000377885.2_De_novo_Start_OutOfFrame|RNF38_ENST00000259605.6_Missense_Mutation_p.P18A|RNF38_ENST00000491349.1_5'UTR	NM_194328.2	NP_919309.1	Q9H0F5	RNF38_HUMAN	ring finger protein 38								zinc ion binding			breast(1)|central_nervous_system(2)|kidney(1)|large_intestine(2)|liver(1)|lung(3)|stomach(1)	11			STAD - Stomach adenocarcinoma(86;0.228)			ACCTTGTTAGGATGGCCAGGT	0.488000													74	488					0	0	1	0	0
FOXI3	344167	broad.mit.edu	37	2	88751603	88751603	+	RNA	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr2:88751603G>A	ENST00000398142.3	-	0	528							A8MTJ6	FOXI3_HUMAN	forkhead box I3						epidermal cell fate specification|otic placode formation|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			NS(1)|endometrium(1)	2						GATGAGCGCCGAATACGAGTA	0.682000													13	33					0	0	1	0	0
CCDC6	8030	broad.mit.edu	37	10	61552865	61552865	+	Missense_Mutation	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr10:61552865G>A	ENST00000263102.6	-	9	1466	c.1235C>T	c.(1234-1236)cCt>cTt	p.P412L		NM_005436.4	NP_005427.2	Q16204	CCDC6_HUMAN	coiled-coil domain containing 6	412						cytoplasm|cytoskeleton	SH3 domain binding|structural constituent of cytoskeleton		CCDC6/RET(4)	breast(3)|central_nervous_system(1)|endometrium(1)|large_intestine(3)|lung(6)|ovary(3)|stomach(1)	18				Kidney(211;0.0597)		CCGTGGTGAAGGCCTCTGCAG	0.562000			T	RET	NSCLC								21	134					0	0	1	0	0
ADPGK	83440	broad.mit.edu	37	15	73045100	73045100	+	Missense_Mutation	SNP	A	A	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr15:73045100A>G	ENST00000311669.8	-	7	1166	c.1073T>C	c.(1072-1074)cTc>cCc	p.L358P	ADPGK_ENST00000456471.2_Missense_Mutation_p.L84P	NM_031284.4	NP_112574.3	Q9BRR6	ADPGK_HUMAN	ADP-dependent glucokinase	359	ADPK.				glycolysis	extracellular region	ADP-specific glucokinase activity|metal ion binding			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|lung(2)|skin(1)	7						GATCCAGAAGAGGATGTCACT	0.517000													84	390					0	0	1	0	0
PITRM1	10531	broad.mit.edu	37	10	3185639	3185639	+	Missense_Mutation	SNP	C	C	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr10:3185639C>A	ENST00000380989.2	-	23	2628	c.2590G>T	c.(2590-2592)Gtg>Ttg	p.V864L	PITRM1-AS1_ENST00000601046.1_RNA|PITRM1_ENST00000451104.2_Missense_Mutation_p.V765L|PITRM1-AS1_ENST00000441377.1_RNA|PITRM1_ENST00000380994.1_Missense_Mutation_p.V421L|PITRM1_ENST00000224949.4_Missense_Mutation_p.V863L|PITRM1_ENST00000464395.1_5'UTR|PITRM1-AS1_ENST00000598280.1_RNA	NM_001242307.1|NM_014889.3	NP_001229236.1|NP_055704.2	E7ES23	E7ES23_HUMAN	pitrilysin metallopeptidase 1	765					proteolysis		metalloendopeptidase activity|zinc ion binding			breast(2)|cervix(1)|endometrium(2)|kidney(5)|large_intestine(5)|liver(1)|lung(5)|ovary(1)|pancreas(1)|prostate(4)|skin(1)|stomach(2)|urinary_tract(3)	33						ACGTAATTCACCGGGAAGGGC	0.592000													18	272					0.000566183	0.000570377	1	1	0
MT-CO1	4512	broad.mit.edu	37	MT	6776	6776	+	Missense_Mutation	SNP	T	T	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:6776T>C	ENST00000361624.2	+	1	873	c.873T>C	c.(871-873)caT>caC	p.291_291insH						mitochondrially encoded cytochrome c oxidase I											breast(4)|endometrium(25)|kidney(19)|lung(3)|prostate(3)	54						TGAGCACACCATATATTTACA	0.423000													8	60					0	0	1	0	0
MT-CYB	4519	broad.mit.edu	37	MT	15452	15452	+	Missense_Mutation	SNP	C	C	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:15452C>A	ENST00000361789.2	+	1	706	c.706C>A	c.(706-708)Ctt>Att	p.236_236insI						mitochondrially encoded cytochrome b											breast(6)|endometrium(25)|kidney(33)|prostate(1)	65						TACTTCTCTTCCTTCTCTCCT	0.478000											OREG0007583	type=REGULATORY REGION|TFbs=ESR1|Dataset=Estrogen Receptor Alpha Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	9	50					5.68852e-11	5.92827e-11	1	1	0
SPG7	6687	broad.mit.edu	37	16	89611106	89611106	+	Missense_Mutation	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr16:89611106G>A	ENST00000268704.2	+	10	1390	c.1375G>A	c.(1375-1377)Gac>Aac	p.D459N		NM_003119.2	NP_003110.1	Q9UQ90	SPG7_HUMAN	spastic paraplegia 7 (pure and complicated autosomal recessive)	459					cell death|nervous system development|protein catabolic process|proteolysis	integral to membrane|mitochondrial membrane	ATP binding|metalloendopeptidase activity|nucleoside-triphosphatase activity|unfolded protein binding|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|ovary(2)|urinary_tract(1)	20		all_hematologic(23;0.00824)|Colorectal(91;0.102)		all cancers(4;1.39e-07)|OV - Ovarian serous cystadenocarcinoma(4;5.64e-06)|BRCA - Breast invasive adenocarcinoma(80;0.015)		GAACCGAGCTGACATTTTGGA	0.602000													68	428					0	0	1	0	0
PRR22	163154	broad.mit.edu	37	19	5783339	5783339	+	Missense_Mutation	SNP	A	A	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr19:5783339A>T	ENST00000419421.2	-	3	1023	c.919T>A	c.(919-921)Tgc>Agc	p.C307S		NM_001134316.1	NP_001127788.1	Q8IZ63	PRR22_HUMAN	proline rich 22	305										endometrium(2)|large_intestine(1)|prostate(1)|urinary_tract(1)	5						GGGACCTCGCACAGGGTACCC	0.642000													39	290					0	0	1	0	0
MCM3	4172	broad.mit.edu	37	6	52146932	52146932	+	Missense_Mutation	SNP	A	A	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr6:52146932A>G	ENST00000596288.1	-	4	604	c.577T>C	c.(577-579)Tgt>Cgt	p.C193R	MCM3_ENST00000419835.2_Missense_Mutation_p.C102R|MCM3_ENST00000229854.7_Missense_Mutation_p.C148R	NM_002388.4	NP_002379.3	P25205	MCM3_HUMAN	minichromosome maintenance complex component 3	148					cell cycle checkpoint|DNA strand elongation involved in DNA replication|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|S phase of mitotic cell cycle	alpha DNA polymerase:primase complex|centrosome|MCM complex|perinuclear region of cytoplasm	ATP binding|DNA binding|helicase activity|protein binding			endometrium(4)|kidney(1)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(1)	20	Lung NSC(77;0.0931)					GTAGCAGGACAGTAGTGGACA	0.488000													69	465					0	0	1	0	0
TUBB8P7	0	broad.mit.edu	37	16	90162368	90162368	+	RNA	SNP	T	T	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr16:90162368T>C	ENST00000567960.1	+	0	1104				TUBB8P7_ENST00000564451.1_RNA																							GCCACCTTCATTGGGAATAAT	0.512000													79	435					0	0	1	0	0
MROH6	642475	broad.mit.edu	37	8	144650380	144650380	+	Missense_Mutation	SNP	G	G	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr8:144650380G>T	ENST00000398882.3	-	11	1952	c.1696C>A	c.(1696-1698)Ctg>Atg	p.L566M	MROH6_ENST00000533679.1_Intron|MROH6_ENST00000534459.1_De_novo_Start_InFrame|MROH6_ENST00000524906.1_De_novo_Start_InFrame	NM_001100878.1	NP_001094348.1			maestro heat-like repeat family member 6																		AACTCCTCCAGCAGGCCCCAG	0.652000													16	95					1.00905e-13	1.05562e-13	1	1	0
ABCB1	5243	broad.mit.edu	37	7	87178760	87178760	+	Silent	SNP	A	A	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr7:87178760A>G	ENST00000265724.3	-	15	2046	c.1629T>C	c.(1627-1629)cgT>cgC	p.R543R	ABCB1_ENST00000543898.1_Silent_p.R479R	NM_000927.4	NP_000918.2	P08183	MDR1_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 1	543	ABC transporter 1.				G2/M transition of mitotic cell cycle|stem cell proliferation	apical plasma membrane|cell surface|Golgi membrane|integral to membrane|intercellular canaliculus|membrane fraction	ATP binding|protein binding|xenobiotic-transporting ATPase activity			NS(1)|breast(6)|central_nervous_system(2)|endometrium(14)|kidney(9)|large_intestine(14)|lung(48)|ovary(4)|prostate(6)|skin(6)|upper_aerodigestive_tract(1)	111	Esophageal squamous(14;0.00164)				Adenosine triphosphate(DB00171)|Alfentanil(DB00802)|Arsenic trioxide(DB01169)|Atazanavir(DB01072)|Carvedilol(DB01136)|Colchicine(DB01394)|Cyclosporine(DB00091)|Daunorubicin(DB00694)|Dipyridamole(DB00975)|Estramustine(DB01196)|Flupenthixol(DB00875)|Imatinib(DB00619)|Itraconazole(DB01167)|Nicardipine(DB00622)|Propafenone(DB01182)|Quinacrine(DB01103)|Quinidine(DB00908)|Ranolazine(DB00243)|Rifampin(DB01045)|Roxithromycin(DB00778)|Saquinavir(DB01232)|Tamoxifen(DB00675)|Vinblastine(DB00570)	GAACCAGGGCACGTGCAATGG	0.547000													76	392					0	0	1	0	0
CTC-435M10.3	0	broad.mit.edu	37	19	41884321	41884321	+	Missense_Mutation	SNP	G	G	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr19:41884321G>C	ENST00000540732.1	+	2	234	c.107G>C	c.(106-108)aGa>aCa	p.R36T	TMEM91_ENST00000604123.1_Missense_Mutation_p.R93T|TMEM91_ENST00000392002.2_Missense_Mutation_p.R36T|TMEM91_ENST00000542945.1_Missense_Mutation_p.R36T|BCKDHA_ENST00000595085.1_Missense_Mutation_p.R36T|TMEM91_ENST00000356385.4_Missense_Mutation_p.R36T|TMEM91_ENST00000544232.1_Missense_Mutation_p.R36T|TMEM91_ENST00000539627.1_Missense_Mutation_p.R36T|TMEM91_ENST00000447302.2_Missense_Mutation_p.R36T|TMEM91_ENST00000436170.2_Missense_Mutation_p.R36T|TMEM91_ENST00000413014.2_Missense_Mutation_p.R36T																							TCCCCCTTAAGAGAGATAGCC	0.612000													32	601					0	0	1	0	0
TBX18	9096	broad.mit.edu	37	6	85457659	85457659	+	Silent	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr6:85457659G>A	ENST00000369663.5	-	5	1255	c.918C>T	c.(916-918)gtC>gtT	p.V306V	TBX18_ENST00000606784.1_Silent_p.V148V|TBX18_ENST00000606521.1_5'UTR	NM_001080508.1	NP_001073977.1	O95935	TBX18_HUMAN	T-box 18	306					multicellular organismal development	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			NS(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(9)|liver(1)|lung(31)|ovary(2)|pancreas(3)|prostate(6)|skin(3)	61		all_cancers(76;0.000283)|Acute lymphoblastic leukemia(125;3.66e-08)|all_hematologic(105;8.61e-05)|all_epithelial(107;0.0858)		BRCA - Breast invasive adenocarcinoma(108;0.0267)		GATAGGCAGTGACGGTTGTGA	0.438000													30	190					0	0	1	0	0
MT-ND4	4538	broad.mit.edu	37	MT	11119	11119	+	Missense_Mutation	SNP	C	C	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:11119C>T	ENST00000361381.2	+	1	360	c.360C>T	c.(358-360)atC>atT	p.120_120insI						mitochondrially encoded NADH dehydrogenase 4											breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|prostate(1)	13						ATATTTTATATCTTCTTCGAA	0.418000													8	79					0	0	1	0	0
MT-CO3	4514	broad.mit.edu	37	MT	9804	9804	+	Missense_Mutation	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:9804G>A	ENST00000362079.2	+	1	598	c.598G>A	c.(598-600)Gcc>Acc	p.200_200insT						mitochondrially encoded cytochrome c oxidase III											breast(1)|endometrium(10)|kidney(14)|lung(1)|urinary_tract(1)	27						CATTTTTTGTAGCCACAGGCT	0.443000													15	85					0	0	1	0	0
MT-CYB	4519	broad.mit.edu	37	MT	14869	14869	+	Missense_Mutation	SNP	G	G	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:14869G>C	ENST00000361789.2	+	1	123	c.123G>C	c.(121-123)ctG>ctC	p.41_41insL						mitochondrially encoded cytochrome b											breast(6)|endometrium(25)|kidney(33)|prostate(1)	65						GGCGCCTGCCTGATCCTCCAA	0.493000													3	35					0	0	1	0	0
MT-ATP6	4508	broad.mit.edu	37	MT	8701	8701	+	Missense_Mutation	SNP	A	A	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:8701A>G	ENST00000361899.2	+	1	175	c.175A>G	c.(175-177)Acc>Gcc	p.T59A						mitochondrially encoded ATP synthase 6											breast(2)|endometrium(7)|kidney(8)|prostate(1)	18						AACAAATGATAGCCATACACA	0.403000													8	97					0	0	1	0	0
MT-CO1	4512	broad.mit.edu	37	MT	5999	5999	+	Missense_Mutation	SNP	T	T	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:5999T>C	ENST00000361624.2	+	1	96	c.96T>C	c.(94-96)gcT>gcC	p.32_32insA						mitochondrially encoded cytochrome c oxidase I											breast(4)|endometrium(25)|kidney(19)|lung(3)|prostate(3)	54						CTAGGCACAGCTCTAAGCCTC	0.493000													7	77					0	0	1	0	0
HMCN1	83872	broad.mit.edu	37	1	185966578	185966578	+	Missense_Mutation	SNP	G	G	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr1:185966578G>C	ENST00000271588.4	+	25	4025	c.3796G>C	c.(3796-3798)Gat>Cat	p.D1266H	HMCN1_ENST00000367492.2_Missense_Mutation_p.D1266H	NM_031935.2	NP_114141.2	Q96RW7	HMCN1_HUMAN	hemicentin 1	1266	Ig-like C2-type 10.				response to stimulus|visual perception	basement membrane	calcium ion binding			NS(2)|autonomic_ganglia(1)|breast(10)|central_nervous_system(2)|cervix(1)|endometrium(28)|haematopoietic_and_lymphoid_tissue(4)|kidney(13)|large_intestine(58)|liver(3)|lung(101)|ovary(23)|pancreas(4)|prostate(20)|skin(8)|stomach(1)|upper_aerodigestive_tract(11)|urinary_tract(18)	308						CACAGTGGAAGATCTAGAACC	0.383000													50	282					0	0	1	0	0
DYRK3	8444	broad.mit.edu	37	1	206822032	206822032	+	Missense_Mutation	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr1:206822032G>A	ENST00000367106.1	+	4	1902	c.1429G>A	c.(1429-1431)Gag>Aag	p.E477K	DYRK3_ENST00000367109.2_Missense_Mutation_p.E497K|DYRK3_ENST00000489878.1_Intron|DYRK3_ENST00000367108.3_Missense_Mutation_p.E477K			O43781	DYRK3_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3	497	Protein kinase.				erythrocyte differentiation	nucleus	ATP binding|magnesium ion binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(2)|endometrium(1)|kidney(2)|large_intestine(9)|lung(8)|skin(1)|stomach(2)	25	Breast(84;0.183)		BRCA - Breast invasive adenocarcinoma(75;0.166)			CTTGTTTATAGAGTTCTTGAA	0.547000													19	575					0	0	1	0	0
STK4	6789	broad.mit.edu	37	20	43703783	43703783	+	Missense_Mutation	SNP	T	T	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr20:43703783T>A	ENST00000372806.3	+	11	1525	c.1430T>A	c.(1429-1431)aTa>aAa	p.I477K	STK4_ENST00000372801.1_3'UTR|STK4_ENST00000499879.2_Missense_Mutation_p.I422K	NM_006282.2	NP_006273.1	Q13043	STK4_HUMAN	serine/threonine kinase 4	477	SARAH.				apoptosis|cell morphogenesis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of apoptosis|protein autophosphorylation	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein homodimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity|transcription factor binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(2)|lung(5)|ovary(1)|prostate(1)|skin(2)	20		Myeloproliferative disorder(115;0.0122)				CTGGATGCCATAGAGGCTAAG	0.572000													11	216					0	0	1	0	0
C3orf37	0	broad.mit.edu	37	3	129020839	129020839	+	Missense_Mutation	SNP	G	G	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr3:129020839G>C	ENST00000383463.4	+	6	771	c.682G>C	c.(682-684)Gac>Cac	p.D228H	C3orf37_ENST00000389735.3_Missense_Mutation_p.D228H|C3orf37_ENST00000502878.2_Missense_Mutation_p.D228H|C3orf37_ENST00000417226.2_Missense_Mutation_p.D186H	NM_020187.2	NP_064572.2	Q96FZ2	CC037_HUMAN		228										breast(1)|endometrium(1)|kidney(2)|lung(5)|ovary(1)|urinary_tract(4)	14						TAAATGGCTTGACTTTGGTGA	0.463000													86	455					0	0	1	0	0
SLC17A9	63910	broad.mit.edu	37	20	61591929	61591929	+	Silent	SNP	C	C	T	rs144534537	by1000genomes	TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr20:61591929C>T	ENST00000370349.3	+	5	657	c.453C>T	c.(451-453)agC>agT	p.S151S	SLC17A9_ENST00000370351.4_Silent_p.S157S|SLC17A9_ENST00000488738.1_3'UTR			Q9BYT1	S17A9_HUMAN	solute carrier family 17 (vesicular nucleotide transporter), member 9	157					exocytosis|transmembrane transport	integral to membrane	transporter activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	23						TCACCTACAGCATCGTGGGCG	0.652000													17	157					0	0	1	0	0
MLLT3	4300	broad.mit.edu	37	9	20414340	20414340	+	Silent	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr9:20414340G>A	ENST00000380338.4	-	5	790	c.504C>T	c.(502-504)agC>agT	p.S168S	MLLT3_ENST00000429426.2_Silent_p.S165S|MLLT3_ENST00000355930.6_5'UTR|MLLT3_ENST00000475957.1_5'UTR	NM_004529.2	NP_004520.2	P42568	AF9_HUMAN	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3	168	Poly-Ser.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding	p.S168S(5)		central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(6)|lung(24)|ovary(1)|prostate(4)|skin(1)|urinary_tract(7)	66				GBM - Glioblastoma multiforme(3;4.35e-105)|Lung(42;3.48e-06)|LUSC - Lung squamous cell carcinoma(42;7.92e-05)		tgctgctgctgctactgctgc	0.537000			T	MLL	ALL								16	313					0	0	1	0	0
MT-ND5	4540	broad.mit.edu	37	MT	13368	13368	+	Silent	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:13368G>A	ENST00000361567.2	+	1	1032	c.1032G>A	c.(1030-1032)ggG>ggA	p.G344G				P03915	NU5M_HUMAN	mitochondrially encoded NADH dehydrogenase 5	344					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(4)|endometrium(29)|kidney(33)|pancreas(1)|prostate(7)	74					NADH(DB00157)	ATGTGCTCCGGGTCCATCATC	0.448000													4	29					0	0	1	0	0
BCAM	4059	broad.mit.edu	37	19	45315574	45315574	+	Missense_Mutation	SNP	A	A	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr19:45315574A>C	ENST00000391955.1	+	3	403	c.359A>C	c.(358-360)gAg>gCg	p.E120A	BCAM_ENST00000270233.6_Missense_Mutation_p.E120A			P50895	BCAM_HUMAN	basal cell adhesion molecule (Lutheran blood group)	120	Ig-like V-type 1.				cell-matrix adhesion	integral to plasma membrane	laminin binding|laminin receptor activity			central_nervous_system(1)|kidney(3)|large_intestine(4)|lung(9)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	22	Lung NSC(12;0.000789)|all_lung(12;0.00218)	Ovarian(192;0.0728)|all_neural(266;0.112)				GTGGGCGACGAGCGAGACTAC	0.682000													13	208					0	0	1	0	0
FBXW7	0	broad.mit.edu	37	4	153332931	153332931	+	Missense_Mutation	SNP	C	C	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr4:153332931C>T	ENST00000281708.4	-	2	1254	c.25G>A	c.(25-27)Ggc>Agc	p.G9S	FBXW7_ENST00000604872.1_Missense_Mutation_p.G9S|FBXW7_ENST00000603548.1_Missense_Mutation_p.G9S|FBXW7_ENST00000603841.1_Missense_Mutation_p.G9S	NM_033632.3	NP_361014.1	Q969H0	FBXW7_HUMAN	F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase	9					interspecies interaction between organisms|lipid homeostasis|negative regulation of DNA endoreduplication|negative regulation of hepatocyte proliferation|negative regulation of Notch signaling pathway|negative regulation of triglyceride biosynthetic process|positive regulation of epidermal growth factor receptor activity|positive regulation of ERK1 and ERK2 cascade|positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process|protein stabilization|protein ubiquitination|regulation of lipid storage|regulation of protein localization|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|sister chromatid cohesion|vasculature development	nucleolus|nucleoplasm|SCF ubiquitin ligase complex	protein binding			NS(1)|biliary_tract(8)|bone(1)|breast(5)|central_nervous_system(6)|cervix(2)|endometrium(36)|haematopoietic_and_lymphoid_tissue(159)|kidney(6)|large_intestine(155)|lung(31)|ovary(10)|pancreas(3)|prostate(2)|skin(6)|stomach(16)|upper_aerodigestive_tract(9)|urinary_tract(6)	462	all_hematologic(180;0.093)	Acute lymphoblastic leukemia(8;0.000629)|all_hematologic(8;0.067)				CTTTTGCTGCCCACAGAGAGC	0.483000			"""Mis, N, D, F"""		"""colorectal, endometrial, T-ALL"""								37	171					0	0	1	0	0
MT-CYB	4519	broad.mit.edu	37	MT	14905	14905	+	Missense_Mutation	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:14905G>A	ENST00000361789.2	+	1	159	c.159G>A	c.(157-159)atG>atA	p.53_53insI						mitochondrially encoded cytochrome b											breast(6)|endometrium(25)|kidney(33)|prostate(1)	65						TTCCTAGCCATACACTACTCA	0.532000													6	26					0	0	1	0	0
TAF1L	138474	broad.mit.edu	37	9	32634851	32634851	+	Silent	SNP	A	A	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr9:32634851A>G	ENST00000242310.4	-	1	816	c.727T>C	c.(727-729)Ttg>Ctg	p.L243L	RP11-555J4.4_ENST00000430787.1_RNA	NM_153809.2	NP_722516.1	Q8IZX4	TAF1L_HUMAN	TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 210kDa-like	243					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			breast(6)|central_nervous_system(4)|endometrium(14)|kidney(11)|large_intestine(32)|liver(2)|lung(68)|ovary(2)|pancreas(2)|prostate(7)|skin(9)|stomach(1)|upper_aerodigestive_tract(1)	159			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		ACACTTGGCAACAGCTTGGTG	0.488000													46	523					0	0	1	0	0
TNXB	7148	broad.mit.edu	37	6	32020759	32020759	+	Missense_Mutation	SNP	C	C	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr6:32020759C>G	ENST00000375244.3	-	26	9004	c.8803G>C	c.(8803-8805)Gaa>Caa	p.E2935Q	TNXB_ENST00000375247.2_Missense_Mutation_p.E2933Q			P22105	TENX_HUMAN	tenascin XB	2980	Fibronectin type-III 21.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding			endometrium(1)|kidney(1)|large_intestine(1)|lung(4)|prostate(1)	8						GCGGGAGTTTCTTCCTCTGCA	0.637000													47	209					0	0	1	0	0
DPP8	54878	broad.mit.edu	37	15	65793003	65793003	+	Silent	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr15:65793003G>A	ENST00000341861.5	-	4	2115	c.535C>T	c.(535-537)Ctg>Ttg	p.L179L	DPP8_ENST00000358939.4_Silent_p.L163L|DPP8_ENST00000559233.1_Silent_p.L179L|DPP8_ENST00000321118.7_Silent_p.L179L|DPP8_ENST00000339244.5_Silent_p.L179L|DPP8_ENST00000321147.6_Silent_p.L179L|DPP8_ENST00000300141.6_Silent_p.L163L	NM_197960.2	NP_932064.1	Q6V1X1	DPP8_HUMAN	dipeptidyl-peptidase 8	179					immune response|proteolysis	cytoplasm|membrane|nucleus	aminopeptidase activity|dipeptidyl-peptidase activity|serine-type peptidase activity	p.L163V(1)		NS(1)|breast(2)|endometrium(3)|large_intestine(11)|lung(11)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	36						GCTTGAAACAGAAATGTTCCA	0.403000													102	757					0	0	1	0	0
MT-ATP6	4508	broad.mit.edu	37	MT	8684	8684	+	Missense_Mutation	SNP	C	C	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:8684C>T	ENST00000361899.2	+	1	158	c.158C>T	c.(157-159)aCc>aTc	p.T53I						mitochondrially encoded ATP synthase 6											breast(2)|endometrium(7)|kidney(8)|prostate(1)	18						AATCAAACTAACCTCAAAACA	0.398000													7	110					0	0	1	0	0
ARHGAP15	55843	broad.mit.edu	37	2	143959733	143959733	+	Missense_Mutation	SNP	C	C	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr2:143959733C>T	ENST00000409869.1	+	4	373	c.196C>T	c.(196-198)Cat>Tat	p.H66Y	ARHGAP15_ENST00000295095.6_Missense_Mutation_p.H66Y			Q53QZ3	RHG15_HUMAN	Rho GTPase activating protein 15	66					regulation of cell shape|small GTPase mediated signal transduction	cytosol|membrane	protein binding|Rac GTPase activator activity			endometrium(1)|kidney(5)|large_intestine(8)|liver(2)|lung(15)|ovary(1)|skin(2)	34				BRCA - Breast invasive adenocarcinoma(221;0.151)		TCATTCACAGCATATCTTGAA	0.303000													66	306					0	0	1	0	0
LARS2	23395	broad.mit.edu	37	3	45533136	45533136	+	Missense_Mutation	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr3:45533136G>A	ENST00000415258.1	+	12	1508	c.1367G>A	c.(1366-1368)gGc>gAc	p.G456D	LARS2_ENST00000414984.1_Missense_Mutation_p.G413D|LARS2-AS1_ENST00000442534.2_RNA|LARS2_ENST00000265537.3_Missense_Mutation_p.G456D			Q15031	SYLM_HUMAN	leucyl-tRNA synthetase 2, mitochondrial	456					leucyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|leucine-tRNA ligase activity			endometrium(1)|large_intestine(5)|lung(8)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	18				BRCA - Breast invasive adenocarcinoma(193;0.0122)|KIRC - Kidney renal clear cell carcinoma(197;0.0313)|Kidney(197;0.0372)	L-Leucine(DB00149)	CGGTACTGGGGCACACCAATC	0.582000													65	298					0	0	1	0	0
CDCA5	113130	broad.mit.edu	37	11	64847203	64847203	+	Silent	SNP	C	C	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr11:64847203C>T	ENST00000275517.3	-	5	472	c.300G>A	c.(298-300)gaG>gaA	p.E100E	CDCA5_ENST00000404147.3_Silent_p.E100E	NM_080668.3	NP_542399.1	Q96FF9	CDCA5_HUMAN	cell division cycle associated 5	100					cell division|double-strand break repair|G1/S transition of mitotic cell cycle|mitotic chromosome condensation|mitotic metaphase plate congression|mitotic sister chromatid cohesion|regulation of cohesin localization to chromatin	cytoplasm|nuclear chromatin|plasma membrane	chromatin binding|identical protein binding			large_intestine(1)|lung(2)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	7						TGAAAAGGTCCTCCTTAGTAA	0.567000													4	67					0	0	1	0	0
CTD-2066L21.3	0	broad.mit.edu	37	5	33162549	33162549	+	RNA	SNP	T	T	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr5:33162549T>C	ENST00000510327.1	-	0	346																											CATCTAATAATGAGCTGGTTC	0.522000													36	299					0	0	1	0	0
PET112	5188	broad.mit.edu	37	4	152638043	152638043	+	Missense_Mutation	SNP	C	C	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr4:152638043C>T	ENST00000263985.6	-	4	665	c.625G>A	c.(625-627)Gat>Aat	p.D209N	PET112_ENST00000512306.1_Missense_Mutation_p.D209N|PET112_ENST00000515812.1_Missense_Mutation_p.D209N	NM_004564.2	NP_004555.1	O75879	GATB_HUMAN	PET112 homolog (yeast)	209						mitochondrion	ATP binding|carbon-nitrogen ligase activity, with glutamine as amido-N-donor|translation factor activity, nucleic acid binding			breast(1)|endometrium(5)|kidney(1)|large_intestine(7)|lung(5)|ovary(1)|prostate(1)|upper_aerodigestive_tract(2)	23					L-Glutamic Acid(DB00142)|L-Glutamine(DB00130)	CTGTTCAAATCAATGAGCGTC	0.493000													58	462					0	0	1	0	0
MT-CO1	4512	broad.mit.edu	37	MT	6047	6047	+	Missense_Mutation	SNP	A	A	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:6047A>G	ENST00000361624.2	+	1	144	c.144A>G	c.(142-144)ctA>ctG	p.48_48insL						mitochondrially encoded cytochrome c oxidase I											breast(4)|endometrium(25)|kidney(19)|lung(3)|prostate(3)	54						GGCAACCTTCTAGGTAACGAC	0.473000													9	74					0	0	1	0	0
CTD-2066L21.3	0	broad.mit.edu	37	5	33162637	33162637	+	RNA	SNP	C	C	T	rs1842247		TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr5:33162637C>T	ENST00000510327.1	-	0	346																											TGTCCCACTACGTGCTGCCCC	0.468000													7	162					0	0	1	0	0
OCRL	4952	broad.mit.edu	37	X	128696369	128696369	+	Silent	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrX:128696369G>A	ENST00000371113.4	+	11	1113	c.948G>A	c.(946-948)ctG>ctA	p.L316L	OCRL_ENST00000357121.5_Silent_p.L316L	NM_000276.3	NP_000267.2	Q01968	OCRL_HUMAN	oculocerebrorenal syndrome of Lowe	316					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	clathrin-coated vesicle|cytosol|early endosome|Golgi stack|Golgi-associated vesicle	GTPase activator activity|phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity|protein binding			breast(1)|endometrium(3)|kidney(4)|large_intestine(11)|lung(24)|ovary(2)|upper_aerodigestive_tract(3)	48						AGGTTCAACTGGTGCGCCTTG	0.403000													85	328					0	0	1	0	0
PRKDC	5591	broad.mit.edu	37	8	48744458	48744458	+	Silent	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr8:48744458G>A	ENST00000314191.2	-	61	8235	c.8179C>T	c.(8179-8181)Ctg>Ttg	p.L2727L	PRKDC_ENST00000523565.1_5'UTR|PRKDC_ENST00000338368.3_Silent_p.L2727L	NM_006904.6	NP_008835.5	P78527	PRKDC_HUMAN	protein kinase, DNA-activated, catalytic polypeptide	2728	KIP-binding.				cellular response to insulin stimulus|double-strand break repair via nonhomologous end joining|peptidyl-serine phosphorylation|positive regulation of transcription from RNA polymerase II promoter	DNA-dependent protein kinase-DNA ligase 4 complex|transcription factor complex	ATP binding|DNA binding|DNA-dependent protein kinase activity|transcription factor binding			NS(1)|autonomic_ganglia(1)|breast(2)|central_nervous_system(9)|cervix(3)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(6)|large_intestine(30)|lung(56)|ovary(6)|pancreas(1)|prostate(8)|skin(7)	147		all_cancers(86;0.0336)|all_epithelial(80;0.00111)|Lung NSC(129;0.00363)|all_lung(136;0.00391)				CGTCTGCGCAGTCGTAGTAGG	0.552000								Non-homologous end-joining					142	774					0	0	1	0	0
ZNF318	24149	broad.mit.edu	37	6	43305986	43305986	+	Missense_Mutation	SNP	C	C	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr6:43305986C>A	ENST00000361428.2	-	10	5827	c.5750G>T	c.(5749-5751)aGt>aTt	p.S1917I	ZNF318_ENST00000318149.3_Intron	NM_014345.2	NP_055160.2	Q5VUA4	ZN318_HUMAN	zinc finger protein 318	1917					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|zinc ion binding			autonomic_ganglia(1)|breast(8)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(11)|lung(21)|ovary(3)|prostate(1)|skin(1)|stomach(1)|urinary_tract(1)	61			Colorectal(64;0.00245)|COAD - Colon adenocarcinoma(64;0.00536)|all cancers(41;0.0171)|OV - Ovarian serous cystadenocarcinoma(102;0.0579)			CCCCTCCTCACTAACAACTGA	0.438000													75	509					3.66258e-25	3.96901e-25	1	1	0
AC016995.3	0	broad.mit.edu	37	2	38709239	38709239	+	RNA	SNP	T	T	C	rs112834477		TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr2:38709239T>C	ENST00000417039.1	-	0	696																											GCCTCATATCTGGGGGAATGT	0.567000													55	336					0	0	1	0	0
CHRNB2	1141	broad.mit.edu	37	1	154544140	154544140	+	Missense_Mutation	SNP	C	C	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr1:154544140C>G	ENST00000368476.3	+	5	1105	c.841C>G	c.(841-843)Ctg>Gtg	p.L281V		NM_000748.2	NP_000739.1	P17787	ACHB2_HUMAN	cholinergic receptor, nicotinic, beta 2 (neuronal)	281					B cell activation|behavioral response to nicotine|calcium ion transport|central nervous system projection neuron axonogenesis|lateral geniculate nucleus development|locomotory behavior|membrane depolarization|memory|negative regulation of action potential|optic nerve morphogenesis|positive regulation of B cell proliferation|positive regulation of dopamine secretion|regulation of circadian sleep/wake cycle, REM sleep|regulation of dendrite morphogenesis|regulation of dopamine metabolic process|regulation of synaptogenesis|response to cocaine|response to ethanol|response to hypoxia|sensory perception of pain|sensory perception of sound|smooth muscle contraction|social behavior|synaptic transmission involved in micturition|synaptic transmission, cholinergic|vestibulocochlear nerve development|visual learning|visual perception	cell junction|external side of plasma membrane|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			cervix(1)|endometrium(2)|kidney(1)|large_intestine(8)|lung(12)|skin(1)|urinary_tract(3)	28	all_lung(78;2.22e-29)|Lung NSC(65;3.66e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)		Nicotine(DB00184)	GGTCTTCCTGCTGCTCATCTC	0.577000													71	623					0	0	1	0	0
RP11-798G7.5	0	broad.mit.edu	37	17	43587730	43587730	+	RNA	SNP	A	A	C	rs142536398	by1000genomes	TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr17:43587730A>C	ENST00000253803.2	+	0	267				LRRC37A4P_ENST00000579913.1_RNA																							GTATTGATTCATTTTATTCAT	0.343000													6	127					0	0	1	0	0
ITGAE	3682	broad.mit.edu	37	17	3661083	3661083	+	Missense_Mutation	SNP	C	C	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr17:3661083C>A	ENST00000263087.4	-	9	1035	c.937G>T	c.(937-939)Ggt>Tgt	p.G313C		NM_002208.4	NP_002199.3	P38570	ITAE_HUMAN	integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide)	313	VWFA.				cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			NS(1)|breast(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(13)|lung(14)|ovary(1)|pancreas(1)|prostate(1)|skin(1)|stomach(1)|upper_aerodigestive_tract(1)	41				UCEC - Uterine corpus endometrioid carcinoma (3;0.0813)		AATATGCCACCATCGGTGAGC	0.542000													186	981					2.29838e-65	2.56212e-65	1	1	0
KIF4B	285643	broad.mit.edu	37	5	154395716	154395716	+	Missense_Mutation	SNP	A	A	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr5:154395716A>C	ENST00000435029.4	+	1	2457	c.2297A>C	c.(2296-2298)gAc>gCc	p.D766A		NM_001099293.1	NP_001092763.1	Q2VIQ3	KIF4B_HUMAN	kinesin family member 4B	766	Interaction with PRC1 (By similarity).				axon guidance|blood coagulation|microtubule-based movement	cytosol|microtubule|nuclear matrix	ATP binding|DNA binding|microtubule motor activity			breast(1)|central_nervous_system(1)|endometrium(7)|kidney(6)|large_intestine(13)|lung(27)|ovary(2)|upper_aerodigestive_tract(1)	58	Renal(175;0.00488)	Medulloblastoma(196;0.0523)	KIRC - Kidney renal clear cell carcinoma(527;0.00112)			CATCTGAATGACCTCCTTGAA	0.458000													41	255					0	0	1	0	0
IGF2R	3482	broad.mit.edu	37	6	160492963	160492963	+	Missense_Mutation	SNP	A	A	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr6:160492963A>C	ENST00000356956.1	+	32	4613	c.4465A>C	c.(4465-4467)Agc>Cgc	p.S1489R		NM_000876.2	NP_000867.2	P11717	MPRI_HUMAN	insulin-like growth factor 2 receptor	1489				S -> N (in Ref. 2; AAA59866).	receptor-mediated endocytosis	cell surface|endocytic vesicle|endosome|integral to plasma membrane|lysosomal membrane|trans-Golgi network transport vesicle	glycoprotein binding|insulin-like growth factor receptor activity|phosphoprotein binding|transporter activity			breast(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(27)|lung(31)|ovary(3)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	95		Breast(66;0.000777)|Ovarian(120;0.0305)		OV - Ovarian serous cystadenocarcinoma(65;2.45e-17)|BRCA - Breast invasive adenocarcinoma(81;1.09e-05)		CATGTTCATCAGCGCCGTGGA	0.517000													24	589					0	0	1	0	0
MT-ND1	4535	broad.mit.edu	37	MT	3438	3438	+	Missense_Mutation	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:3438G>A	ENST00000361390.2	+	1	132	c.132G>A	c.(130-132)ggG>ggA	p.44_44insG						mitochondrially encoded NADH dehydrogenase 1											breast(1)|endometrium(13)|kidney(17)|lung(2)|prostate(1)	34						GGCCCCTACGGGCTACTACAA	0.498000													4	31					0	0	1	0	0
SLC3A2	6520	broad.mit.edu	37	11	62648627	62648627	+	Missense_Mutation	SNP	G	G	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr11:62648627G>C	ENST00000377892.1	+	5	752	c.528G>C	c.(526-528)aaG>aaC	p.K176N	SLC3A2_ENST00000377891.2_Missense_Mutation_p.K146N|SLC3A2_ENST00000377890.2_Missense_Mutation_p.K145N|SLC3A2_ENST00000338663.7_Missense_Mutation_p.K44N|SLC3A2_ENST00000535296.1_Missense_Mutation_p.K114N|SLC3A2_ENST00000377889.2_Missense_Mutation_p.K83N			P08195	4F2_HUMAN	solute carrier family 3 (amino acid transporter heavy chain), member 2	145					blood coagulation|carbohydrate metabolic process|cell growth|cellular nitrogen compound metabolic process|leucine import|leukocyte migration|tryptophan transport	apical plasma membrane|cell surface|integral to membrane|melanosome	calcium:sodium antiporter activity|catalytic activity|cation binding|neutral amino acid transmembrane transporter activity|protein binding			endometrium(1)|kidney(3)|large_intestine(2)|lung(12)|ovary(1)|prostate(1)|skin(2)	22						GTCTGGTGAAGATCAAGGTGG	0.657000											OREG0021031	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	44					0	0	1	0	0
MAP3K10	4294	broad.mit.edu	37	19	40711993	40711993	+	Missense_Mutation	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr19:40711993G>A	ENST00000253055.3	+	5	1652	c.1364G>A	c.(1363-1365)cGc>cAc	p.R455H		NM_002446.3	NP_002437.2	Q02779	M3K10_HUMAN	mitogen-activated protein kinase kinase kinase 10	455	Arg/Lys-rich (basic).				activation of JUN kinase activity|induction of apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription, DNA-dependent|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|positive regulation of JNK cascade|protein autophosphorylation|smoothened signaling pathway	cytoplasm	ATP binding|bHLH transcription factor binding|JUN kinase kinase kinase activity|protein homodimerization activity|transcription corepressor activity			NS(1)|breast(1)|endometrium(4)|kidney(3)|large_intestine(4)|lung(5)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	24						GTCCGCAAGCGCAAGGGCAAC	0.672000													31	128					0	0	1	0	0
MT-ND5	4540	broad.mit.edu	37	MT	13743	13743	+	Silent	SNP	T	T	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:13743T>C	ENST00000361567.2	+	1	1407	c.1407T>C	c.(1405-1407)acT>acC	p.T469T				P03915	NU5M_HUMAN	mitochondrially encoded NADH dehydrogenase 5	469					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(4)|endometrium(29)|kidney(33)|pancreas(1)|prostate(7)	74					NADH(DB00157)	TTTCTCATTACTAACAACATT	0.493000													3	21					0	0	1	0	0
ZSCAN5B	342933	broad.mit.edu	37	19	56701318	56701318	+	Missense_Mutation	SNP	C	C	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr19:56701318C>T	ENST00000586855.2	-	5	1679	c.1366G>A	c.(1366-1368)Gtt>Att	p.V456I	ZSCAN5B_ENST00000358992.3_Missense_Mutation_p.V456I			A6NJL1	ZSA5B_HUMAN	zinc finger and SCAN domain containing 5B	456					viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(1)|endometrium(5)|large_intestine(3)|lung(23)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	37						CGCTGGTGAACGTTCAGGTTC	0.537000													11	248					0	0	1	0	0
ADAMTS10	81794	broad.mit.edu	37	19	8661292	8661292	+	Silent	SNP	C	C	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr19:8661292C>A	ENST00000270328.4	-	9	1355	c.1089G>T	c.(1087-1089)ctG>ctT	p.L363L	ADAMTS10_ENST00000597188.1_Silent_p.L363L			Q9H324	ATS10_HUMAN	ADAM metallopeptidase with thrombospondin type 1 motif, 10	363	Peptidase M12B.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(16)|large_intestine(5)|lung(9)|ovary(1)|pancreas(2)|prostate(3)|skin(10)|urinary_tract(1)	53						CCACCGGGGCCAGGCCTGGGA	0.657000													15	137					3.45872e-05	3.51034e-05	1	1	0
LRRC6	23639	broad.mit.edu	37	8	133595976	133595976	+	Silent	SNP	A	A	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr8:133595976A>T	ENST00000519595.1	-	11	1289	c.1191T>A	c.(1189-1191)acT>acA	p.T397T	LRRC6_ENST00000518642.1_Silent_p.T394T|LRRC6_ENST00000250173.1_Silent_p.T397T			Q86X45	LRRC6_HUMAN	leucine rich repeat containing 6	397						cytoplasm				breast(2)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(18)|ovary(1)|prostate(1)|urinary_tract(2)	34	Ovarian(258;0.00352)|Esophageal squamous(12;0.00507)|all_neural(3;0.0052)|Medulloblastoma(3;0.0922)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000311)			TGTCCGAGGTAGTTTTCATAG	0.403000													32	325					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197404147	197404147	+	Missense_Mutation	SNP	C	C	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr1:197404147C>G	ENST00000367397.1	+	5	2155	c.1297C>G	c.(1297-1299)Caa>Gaa	p.Q433E	CRB1_ENST00000544212.1_Missense_Mutation_p.Q533E|CRB1_ENST00000367400.3_Missense_Mutation_p.Q1052E|CRB1_ENST00000367399.2_Missense_Mutation_p.Q940E|CRB1_ENST00000538660.1_Intron|CRB1_ENST00000535699.1_Missense_Mutation_p.Q1028E			P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)	1052	EGF-like 10; calcium-binding (Potential).		Y -> C (in RP12).		cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						CTCCAGGTGGCAAATGGAAGT	0.453000													22	492					0	0	1	0	0
TRIML1	339976	broad.mit.edu	37	4	189065010	189065010	+	Missense_Mutation	SNP	G	G	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr4:189065010G>C	ENST00000332517.3	+	4	894	c.754G>C	c.(754-756)Gaa>Caa	p.E252Q	TRIML1_ENST00000507581.1_3'UTR	NM_178556.3	NP_848651.2	Q8N9V2	TRIML_HUMAN	tripartite motif family-like 1	252					multicellular organismal development		ligase activity|zinc ion binding			NS(3)|breast(2)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(30)|ovary(2)|pancreas(1)|skin(3)|upper_aerodigestive_tract(1)	60		all_cancers(14;1.33e-43)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)|all_hematologic(60;0.062)		OV - Ovarian serous cystadenocarcinoma(60;1.52e-11)|BRCA - Breast invasive adenocarcinoma(30;4.19e-06)|GBM - Glioblastoma multiforme(59;0.000232)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.00902)|READ - Rectum adenocarcinoma(43;0.156)		AGGAGCCCTGGAAAGGTAGGC	0.488000													155	741					0	0	1	0	0
CHD4	1108	broad.mit.edu	37	12	6692545	6692545	+	Splice_Site	SNP	C	C	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr12:6692545C>A	ENST00000309577.6	-	26	4043		c.e26-1		CHD4_ENST00000544484.1_Splice_Site|CHD4_ENST00000544040.1_Splice_Site|CHD4_ENST00000357008.2_Splice_Site|RP5-940J5.6_ENST00000501075.2_RNA|CHD4_ENST00000540960.1_Intron			Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4						chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						CCTCTTCCTCCTGGGACAGAG	0.532000													24	660					3.5997e-14	3.78038e-14	1	1	0
BCL11A	53335	broad.mit.edu	37	2	60688255	60688255	+	Missense_Mutation	SNP	C	C	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr2:60688255C>A	ENST00000335712.6	-	4	2019	c.1792G>T	c.(1792-1794)Gac>Tac	p.D598Y	BCL11A_ENST00000477659.1_5'UTR|BCL11A_ENST00000538214.1_Missense_Mutation_p.D564Y|BCL11A_ENST00000358510.4_Missense_Mutation_p.D564Y|BCL11A_ENST00000356842.4_Missense_Mutation_p.D598Y|BCL11A_ENST00000537768.1_Missense_Mutation_p.D267Y|BCL11A_ENST00000359629.5_Intron	NM_022893.3	NP_075044.2	Q9H165	BC11A_HUMAN	B-cell CLL/lymphoma 11A (zinc finger protein)	598					negative regulation of axon extension|negative regulation of collateral sprouting|negative regulation of dendrite development|positive regulation of collateral sprouting|positive regulation of neuron projection development|positive regulation of transcription from RNA polymerase II promoter|protein sumoylation|regulation of dendrite development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	nucleic acid binding|protein heterodimerization activity|protein homodimerization activity|zinc ion binding			NS(1)|breast(6)|central_nervous_system(6)|endometrium(4)|kidney(1)|large_intestine(8)|lung(25)|ovary(2)|pancreas(1)|prostate(2)|skin(3)	59			LUSC - Lung squamous cell carcinoma(5;9.29e-08)|Lung(5;1.34e-06)|Epithelial(17;0.0562)|all cancers(80;0.199)			GTGCCATCGTCTATGCGGTCC	0.697000			T	IGH@	B-CLL								34	188					2.09667e-21	2.24525e-21	1	1	0
DLG5	9231	broad.mit.edu	37	10	79589222	79589222	+	Silent	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr10:79589222G>A	ENST00000372391.2	-	12	2081	c.2076C>T	c.(2074-2076)atC>atT	p.I692I	DLG5_ENST00000372388.2_Silent_p.I692I	NM_004747.3	NP_004738.3	Q8TDM6	DLG5_HUMAN	discs, large homolog 5 (Drosophila)	692	PDZ 1.				cell-cell adhesion|intracellular signal transduction|negative regulation of cell proliferation|regulation of apoptosis	cell junction|cytoplasm	beta-catenin binding|cytoskeletal protein binding|receptor signaling complex scaffold activity			breast(9)|central_nervous_system(3)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(8)|lung(17)|ovary(5)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(2)	60	all_cancers(46;0.0316)|all_epithelial(25;0.00147)|Breast(12;0.0015)|Prostate(51;0.0146)		Epithelial(14;0.00105)|OV - Ovarian serous cystadenocarcinoma(4;0.00151)|all cancers(16;0.00446)			GGAGCGCCTTGATGGCCTGCT	0.587000													25	750					0	0	1	0	0
ESPNP	0	broad.mit.edu	37	1	17033708	17033708	+	RNA	SNP	A	A	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr1:17033708A>G	ENST00000492551.1	-	0	696					NR_026567.1																						ccttggtaaaaggggtgacga	0.612000													5	20					0	0	1	0	0
SHARPIN	81858	broad.mit.edu	37	8	145154701	145154701	+	Missense_Mutation	SNP	C	C	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr8:145154701C>G	ENST00000398712.2	-	4	1000	c.564G>C	c.(562-564)gaG>gaC	p.E188D	SHARPIN_ENST00000533948.1_5'UTR	NM_030974.3	NP_112236.3	Q9H0F6	SHRPN_HUMAN	SHANK-associated RH domain interactor	188	Interaction with SHANK1 (By similarity).				negative regulation of inflammatory response|positive regulation of I-kappaB kinase/NF-kappaB cascade|protein linear polyubiquitination|regulation of CD40 signaling pathway|regulation of tumor necrosis factor-mediated signaling pathway	cytosol|LUBAC complex	polyubiquitin binding|zinc ion binding			breast(1)|endometrium(1)|kidney(1)|lung(2)|ovary(2)	7	all_cancers(97;2.87e-11)|all_epithelial(106;2.16e-09)|Lung NSC(106;5.89e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.1e-42)|Epithelial(56;1.58e-40)|all cancers(56;6.12e-36)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			CTGCCCCCTTCTCGTCTCCAC	0.637000													44	379					0	0	1	0	0
SLITRK3	22865	broad.mit.edu	37	3	164908435	164908435	+	Missense_Mutation	SNP	C	C	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr3:164908435C>T	ENST00000475390.1	-	2	627	c.184G>A	c.(184-186)Gac>Aac	p.D62N	SLITRK3_ENST00000241274.3_Missense_Mutation_p.D62N			O94933	SLIK3_HUMAN	SLIT and NTRK-like family, member 3	62						integral to membrane				NS(1)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(14)|lung(66)|ovary(6)|pancreas(1)|prostate(4)|skin(5)|upper_aerodigestive_tract(5)	119						CCTTTACTGTCACAATGTATA	0.373000										HNSCC(40;0.11)			61	505					0	0	1	0	0
SLC45A4	57210	broad.mit.edu	37	8	142222650	142222650	+	Missense_Mutation	SNP	G	G	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr8:142222650G>C	ENST00000519067.1	-	7	2097	c.1794C>G	c.(1792-1794)atC>atG	p.I598M	SLC45A4_ENST00000517878.1_Missense_Mutation_p.I649M|SLC45A4_ENST00000024061.3_Missense_Mutation_p.I598M|SLC45A4_ENST00000433583.2_Missense_Mutation_p.I591M			Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	649					transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			GGCTGTGGTGGATGTACTGCA	0.567000													11	204					0	0	1	0	0
C17orf47	284083	broad.mit.edu	37	17	56620313	56620313	+	Missense_Mutation	SNP	G	G	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr17:56620313G>T	ENST00000321691.3	-	1	1416	c.1235C>A	c.(1234-1236)cCc>cAc	p.P412H	RP11-112H10.4_ENST00000578022.1_RNA|RP11-112H10.4_ENST00000580769.1_RNA|RP11-112H10.4_ENST00000580589.1_RNA	NM_001038704.2	NP_001033793.2	Q8NEP4	CQ047_HUMAN	chromosome 17 open reading frame 47	412										NS(1)|breast(2)|endometrium(1)|kidney(4)|large_intestine(4)|lung(9)|prostate(1)|skin(1)|urinary_tract(1)	24	Medulloblastoma(34;0.127)|all_neural(34;0.237)					AGGAGGCAAGGGCCTAGGGGT	0.547000													58	567					1.19403e-26	1.30959e-26	1	1	0
OPRL1	4987	broad.mit.edu	37	20	62729444	62729444	+	Missense_Mutation	SNP	T	T	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr20:62729444T>A	ENST00000349451.3	+	5	935	c.523T>A	c.(523-525)Tgg>Agg	p.W175R	OPRL1_ENST00000355631.4_Missense_Mutation_p.W175R|OPRL1_ENST00000336866.2_Missense_Mutation_p.W175R	NM_001200019.1	NP_001186948.1	P41146	OPRX_HUMAN	opiate receptor-like 1	175					elevation of cytosolic calcium ion concentration|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception	integral to plasma membrane	protein binding|X-opioid receptor activity			central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(2)|lung(10)|ovary(1)|skin(2)|urinary_tract(1)	19	all_cancers(38;4.74e-11)|all_epithelial(29;1.33e-12)|Lung NSC(23;3.27e-09)|all_lung(23;1.02e-08)					TGTGGCCATCTGGGCCCTGGC	0.627000													49	488					0	0	1	0	0
C1QL3	389941	broad.mit.edu	37	10	16562659	16562659	+	Nonsense_Mutation	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr10:16562659G>A	ENST00000298943.3	-	1	1345	c.406C>T	c.(406-408)Cag>Tag	p.Q136*		NM_001010908.1	NP_001010908.1	Q5VWW1	C1QL3_HUMAN	complement component 1, q subcomponent-like 3	136	C1q.					collagen				breast(1)|endometrium(3)|kidney(1)|lung(4)|ovary(1)|prostate(1)|stomach(1)|upper_aerodigestive_tract(1)	13						CCTTCATGCTGCCGCTTGAGG	0.687000													12	318					0	0	1	0	0
SMARCA1	6594	broad.mit.edu	37	X	128624058	128624058	+	Missense_Mutation	SNP	C	C	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrX:128624058C>T	ENST00000371122.4	-	15	2056	c.1927G>A	c.(1927-1929)Gat>Aat	p.D643N	SMARCA1_ENST00000371123.1_Missense_Mutation_p.D631N|SMARCA1_ENST00000371121.3_Missense_Mutation_p.D631N	NM_003069.3	NP_003060.2	P28370	SMCA1_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1	643	Helicase C-terminal.				ATP-dependent chromatin remodeling|brain development|neuron differentiation|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	NURF complex	ATP binding|DNA binding|helicase activity|nucleosome binding|protein binding			biliary_tract(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(11)|liver(1)|lung(13)|ovary(5)|prostate(1)|skin(1)	45						ACAATTGAATCGAGTCTCAGT	0.328000													26	84					0	0	1	0	0
SNX24	28966	broad.mit.edu	37	5	122272452	122272452	+	Missense_Mutation	SNP	G	G	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr5:122272452G>C	ENST00000261369.4	+	2	269	c.84G>C	c.(82-84)atG>atC	p.M28I	SNX24_ENST00000511211.1_3'UTR|SNX24_ENST00000395451.4_Missense_Mutation_p.M61I|SNX24_ENST00000513881.1_Missense_Mutation_p.M28I|SNX24_ENST00000506996.1_Missense_Mutation_p.M28I	NM_014035.2	NP_054754.1	Q9Y343	SNX24_HUMAN	sorting nexin 24	28	PX.				cell communication|protein transport	cytoplasmic vesicle membrane	phosphatidylinositol binding			lung(5)	5		Prostate(80;0.0387)	KIRC - Kidney renal clear cell carcinoma(527;0.0897)|Kidney(363;0.137)	OV - Ovarian serous cystadenocarcinoma(64;0.000654)|Epithelial(69;0.0016)|all cancers(49;0.0139)		AAGTGCTAATGAATGGAAGAA	0.313000													49	172					0	0	1	0	0
MT-CYB	4519	broad.mit.edu	37	MT	15607	15607	+	Missense_Mutation	SNP	A	A	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:15607A>G	ENST00000361789.2	+	1	861	c.861A>G	c.(859-861)aaA>aaG	p.287_287insK						mitochondrially encoded cytochrome b											breast(6)|endometrium(25)|kidney(33)|prostate(1)	65						GTCCCTAACAAACTAGGAGGC	0.453000											OREG0007583	type=REGULATORY REGION|TFbs=ESR1|Dataset=Estrogen Receptor Alpha Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	10	60					0	0	1	0	0
TAPT1-AS1	0	broad.mit.edu	37	4	16258063	16258063	+	RNA	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr4:16258063G>A	ENST00000570786.1	+	0	418				TAPT1-AS1_ENST00000573308.1_RNA|TAPT1-AS1_ENST00000573950.1_RNA	NR_027696.1																						GACCTTGTCAGCCTCGGCCAC	0.547000													16	218					0	0	1	0	0
MT-ND4	4538	broad.mit.edu	37	MT	11764	11764	+	Missense_Mutation	SNP	A	A	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:11764A>G	ENST00000361381.2	+	1	1005	c.1005A>G	c.(1003-1005)gaA>gaG	p.335_335insE						mitochondrially encoded NADH dehydrogenase 4											breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|prostate(1)	13						TCAAACTACGAACGCACTCAC	0.483000													11	115					0	0	1	0	0
MT-ATP6	4508	broad.mit.edu	37	MT	9117	9117	+	Silent	SNP	T	T	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:9117T>C	ENST00000361899.2	+	1	591	c.591T>C	c.(589-591)atT>atC	p.I197I						mitochondrially encoded ATP synthase 6											breast(2)|endometrium(7)|kidney(8)|prostate(1)	18						ACAATTCTAATTCTACTGACT	0.443000													5	60					0	0	1	0	0
ZRANB3	84083	broad.mit.edu	37	2	135988368	135988368	+	Missense_Mutation	SNP	T	T	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr2:135988368T>C	ENST00000401392.1	-	13	1881	c.1669A>G	c.(1669-1671)Aca>Gca	p.T557A	ZRANB3_ENST00000264159.6_Missense_Mutation_p.T557A|ZRANB3_ENST00000536680.1_Missense_Mutation_p.T557A|ZRANB3_ENST00000412849.1_5'UTR			Q5FWF4	ZRAB3_HUMAN	zinc finger, RAN-binding domain containing 3	557						intracellular	ATP binding|DNA binding|endonuclease activity|helicase activity|zinc ion binding			NS(2)|endometrium(2)|kidney(2)|large_intestine(3)|lung(10)|upper_aerodigestive_tract(1)	20				BRCA - Breast invasive adenocarcinoma(221;0.135)		GCTGTTTTTGTAGGGTCTGAT	0.413000													33	415					0	0	1	0	0
COMMD8	54951	broad.mit.edu	37	4	47462175	47462175	+	Missense_Mutation	SNP	A	A	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr4:47462175A>C	ENST00000381571.4	-	2	275	c.208T>G	c.(208-210)Tta>Gta	p.L70V		NM_017845.3	NP_060315.1	Q9NX08	COMD8_HUMAN	COMM domain containing 8	70							protein binding			large_intestine(2)|lung(5)|prostate(1)	8						TCATCAGGTAAGTTTTTACCA	0.343000													58	397					0	0	1	0	0
RRN3P1	0	broad.mit.edu	37	16	21817457	21817457	+	RNA	SNP	G	G	A	rs150520281	by1000genomes	TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr16:21817457G>A	ENST00000546471.1	-	0	1601																											CTTACATCCAGCTTGAGTAGT	0.259000													10	104					0	0	1	0	0
MT-RNR2	0	broad.mit.edu	37	MT	1811	1811	+	RNA	SNP	A	A	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:1811A>G	ENST00000387347.2	+	0	141					NR_039705.1																						TGAAAAATTATAACCAAGCAT	0.378000													7	87					0	0	1	0	0
TDG	6996	broad.mit.edu	37	12	104373759	104373759	+	Missense_Mutation	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr12:104373759G>A	ENST00000392872.3	+	3	551	c.317G>A	c.(316-318)aGa>aAa	p.R106K	TDG_ENST00000544861.1_5'UTR|TDG_ENST00000542036.1_5'UTR|TDG_ENST00000266775.9_Missense_Mutation_p.R102K	NM_003211.4	NP_003202.3	Q13569	TDG_HUMAN	thymine-DNA glycosylase	106					depyrimidination|mismatch repair	nucleoplasm	damaged DNA binding|mismatched DNA binding|protein binding|pyrimidine-specific mismatch base pair DNA N-glycosylase activity			large_intestine(2)|lung(14)|ovary(4)|skin(1)|stomach(2)|upper_aerodigestive_tract(1)	24				BRCA - Breast invasive adenocarcinoma(302;0.00114)		AAAGTAAAAAGAAAAGTAGAC	0.353000								Base excision repair (BER), DNA glycosylases					29	294					0	0	1	0	0
FASN	2194	broad.mit.edu	37	17	80049208	80049208	+	Missense_Mutation	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr17:80049208G>A	ENST00000306749.2	-	9	1600	c.1382C>T	c.(1381-1383)cCc>cTc	p.P461L		NM_004104.4	NP_004095.4	P49327	FAS_HUMAN	fatty acid synthase	461	Acyl and malonyl transferases (By similarity).			AVPA -> LSPT (in Ref. 2; AAA73576).	energy reserve metabolic process|fatty acid biosynthetic process|long-chain fatty-acyl-CoA biosynthetic process|pantothenate metabolic process|positive regulation of cellular metabolic process|triglyceride biosynthetic process	cytosol|Golgi apparatus|melanosome|plasma membrane	3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity|3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity|3-oxoacyl-[acyl-carrier-protein] synthase activity|[acyl-carrier-protein] S-acetyltransferase activity|[acyl-carrier-protein] S-malonyltransferase activity|acyl carrier activity|cofactor binding|enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity|myristoyl-[acyl-carrier-protein] hydrolase activity|oleoyl-[acyl-carrier-protein] hydrolase activity|palmitoyl-[acyl-carrier-protein] hydrolase activity|phosphopantetheine binding|protein binding|zinc ion binding			central_nervous_system(3)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(12)|prostate(3)|skin(2)|urinary_tract(1)	34	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		OV - Ovarian serous cystadenocarcinoma(97;0.0211)|BRCA - Breast invasive adenocarcinoma(99;0.0237)		Cerulenin(DB01034)|Orlistat(DB01083)|Pyrazinamide(DB00339)	GGCGGTGGCGGGGACAGCCGC	0.701000													15	87					0	0	1	0	0
SLC25A13	10165	broad.mit.edu	37	7	95818665	95818665	+	Silent	SNP	G	G	T	rs142308242		TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr7:95818665G>T	ENST00000416240.2	-	9	1064	c.874C>A	c.(874-876)Cgg>Agg	p.R292R	SLC25A13_ENST00000265631.5_Silent_p.R292R|SLC25A13_ENST00000542654.1_Silent_p.R184R	NM_001160210.1|NM_014251.2	NP_001153682.1|NP_055066.1	Q9UJS0	CMC2_HUMAN	solute carrier family 25 (aspartate/glutamate carrier), member 13	292					ATP biosynthetic process|gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to plasma membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity			breast(4)|central_nervous_system(3)|endometrium(4)|kidney(2)|large_intestine(8)|liver(2)|lung(14)|prostate(1)|skin(4)	42	all_cancers(62;7.75e-08)|all_epithelial(64;1.16e-07)		STAD - Stomach adenocarcinoma(171;0.194)		L-Aspartic Acid(DB00128)	GGAGCAATCCGTTCAATGTCT	0.408000													31	148					9.17885e-22	9.86817e-22	1	1	0
EHBP1L1	254102	broad.mit.edu	37	11	65351822	65351822	+	Missense_Mutation	SNP	C	C	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr11:65351822C>G	ENST00000309295.4	+	10	3469	c.3204C>G	c.(3202-3204)aaC>aaG	p.N1068K		NM_001099409.1	NP_001092879.1	Q8N3D4	EH1L1_HUMAN	EH domain binding protein 1-like 1	1068	CH.									central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(3)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)	23						CCTGGCGCAACGGCTTGGCCT	0.622000													16	415					0	0	1	0	0
MT-ND4	4538	broad.mit.edu	37	MT	11812	11812	+	Missense_Mutation	SNP	A	A	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:11812A>G	ENST00000361381.2	+	1	1053	c.1053A>G	c.(1051-1053)ctA>ctG	p.351_351insL						mitochondrially encoded NADH dehydrogenase 4											breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|prostate(1)	13						CTTCAAACTCTACTCCCACTA	0.473000													38	85					0	0	1	0	0
PPOX	5498	broad.mit.edu	37	1	161139773	161139773	+	Missense_Mutation	SNP	G	G	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr1:161139773G>T	ENST00000367999.4	+	9	1212	c.946G>T	c.(946-948)Gtg>Ttg	p.V316L	PPOX_ENST00000535223.1_Intron|PPOX_ENST00000352210.5_Missense_Mutation_p.V316L|PPOX_ENST00000544598.1_Intron|PPOX_ENST00000432542.2_Intron|PPOX_ENST00000495483.1_3'UTR	NM_001122764.1	NP_001116236.1	P50336	PPOX_HUMAN	protoporphyrinogen oxidase	316					heme biosynthetic process	intrinsic to mitochondrial inner membrane|mitochondrial intermembrane space	flavin adenine dinucleotide binding|oxygen-dependent protoporphyrinogen oxidase activity			breast(1)|cervix(1)|endometrium(1)|large_intestine(3)|lung(5)|ovary(1)|urinary_tract(3)	15	all_cancers(52;3.73e-19)|Breast(13;0.000577)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00275)			GTCTGTAGCTGTGGTGAATCT	0.577000													19	187					8.28177e-16	8.73117e-16	1	1	0
NACA2	342538	broad.mit.edu	37	17	59668536	59668536	+	Silent	SNP	C	C	G	rs112308210		TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr17:59668536C>G	ENST00000521764.1	-	1	27	c.6G>C	c.(4-6)ccG>ccC	p.P2P		NM_199290.3	NP_954984.1	Q9H009	NACA2_HUMAN	nascent polypeptide-associated complex alpha subunit 2	2					protein transport	cytoplasm|nucleus				large_intestine(1)|lung(5)|ovary(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	12	all_epithelial(1;3.12e-14)					TGGCTTCGCCCGGCATTTTGT	0.577000													13	382					0	0	1	0	0
OR10K2	391107	broad.mit.edu	37	1	158390123	158390123	+	Silent	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr1:158390123G>A	ENST00000314902.2	-	1	533	c.534C>T	c.(532-534)ttC>ttT	p.F178F		NM_001004476.1	NP_001004476.1	Q6IF99	O10K2_HUMAN	olfactory receptor, family 10, subfamily K, member 2	178					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|breast(1)|cervix(2)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(19)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	36	all_hematologic(112;0.0378)					CAATGTCACAGAAGAAGTGAT	0.463000													91	470					0	0	1	0	0
PLK4	0	broad.mit.edu	37	4	128804674	128804674	+	Silent	SNP	A	A	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr4:128804674A>G	ENST00000270861.5	+	4	577	c.303A>G	c.(301-303)ctA>ctG	p.L101L	PLK4_ENST00000513090.1_Silent_p.L69L|PLK4_ENST00000514379.1_Silent_p.L60L|PLK4_ENST00000515069.1_Silent_p.L101L|PLK4_ENST00000507249.1_Silent_p.L101L	NM_014264.4	NP_055079.3	O00444	PLK4_HUMAN	polo-like kinase 4	101	Protein kinase.				G2/M transition of mitotic cell cycle|positive regulation of centriole replication|trophoblast giant cell differentiation	centriole|cleavage furrow|cytosol|nucleolus	ATP binding|protein binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(10)|lung(12)|prostate(1)|upper_aerodigestive_tract(1)	31						ACAGGTATCTAAAGAATAGAG	0.323000													86	257					0	0	1	0	0
RAB3GAP2	25782	broad.mit.edu	37	1	220326745	220326745	+	Missense_Mutation	SNP	A	A	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr1:220326745A>C	ENST00000358951.2	-	33	3765	c.3649T>G	c.(3649-3651)Tta>Gta	p.L1217V		NM_012414.3	NP_036546.2	Q9H2M9	RBGPR_HUMAN	RAB3 GTPase activating protein subunit 2 (non-catalytic)	1217					intracellular protein transport	cytoplasm|soluble fraction	GTPase activator activity|protein heterodimerization activity	p.L1217V(1)		breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(8)|lung(13)|ovary(1)|pancreas(1)|prostate(4)|skin(1)|urinary_tract(1)	39				GBM - Glioblastoma multiforme(131;0.0443)		ACTTTCAATAAGAACTTGAAA	0.408000													80	370					0	0	1	0	0
KAT6A	7994	broad.mit.edu	37	8	41834718	41834718	+	Missense_Mutation	SNP	C	C	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr8:41834718C>G	ENST00000396930.3	-	8	1714	c.1171G>C	c.(1171-1173)Gac>Cac	p.D391H	KAT6A_ENST00000485568.1_Missense_Mutation_p.D391H|KAT6A_ENST00000265713.2_Missense_Mutation_p.D391H|KAT6A_ENST00000406337.1_Missense_Mutation_p.D391H	NM_001099412.1	NP_001092882.1	Q92794	MYST3_HUMAN	K(lysine) acetyltransferase 6A	391	Interaction with RUNX1-1.				histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding										CTGCAGAAGTCCAAGCCATCT	0.453000													47	491					0	0	1	0	0
MT-RNR2	0	broad.mit.edu	37	MT	2141	2141	+	RNA	SNP	T	T	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:2141T>C	ENST00000387347.2	+	0	471					NR_039705.1																						GAAAAAACCTTGTAGAGAGAG	0.383000													13	104					0	0	1	0	0
AC016995.3	0	broad.mit.edu	37	2	38709079	38709079	+	RNA	SNP	C	C	T	rs111340107		TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr2:38709079C>T	ENST00000417039.1	-	0	696																											AATGTTTCATCGTGGGAGCAG	0.537000													20	171					0	0	1	0	0
ZIC5	85416	broad.mit.edu	37	13	100617947	100617947	+	Missense_Mutation	SNP	T	T	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr13:100617947T>A	ENST00000267294.4	-	2	1909	c.1676A>T	c.(1675-1677)gAc>gTc	p.D559V		NM_033132.3	NP_149123.2	Q96T25	ZIC5_HUMAN	Zic family member 5	559					cell differentiation	nucleus	DNA binding|zinc ion binding			endometrium(3)|kidney(1)|lung(2)|prostate(1)|skin(2)	9	all_neural(89;0.0837)|Medulloblastoma(90;0.18)|Lung SC(71;0.184)					GTAGGATTTGTCACAGCCTCG	0.522000													140	394					0	0	1	0	0
ANKRD13D	338692	broad.mit.edu	37	11	67067334	67067334	+	Missense_Mutation	SNP	C	C	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr11:67067334C>T	ENST00000447274.2	+	9	1831	c.656C>T	c.(655-657)gCg>gTg	p.A219V	ANKRD13D_ENST00000308440.6_Missense_Mutation_p.A219V|ANKRD13D_ENST00000511455.2_Missense_Mutation_p.A306V|ANKRD13D_ENST00000514166.1_Missense_Mutation_p.A219V			Q6ZTN6	AN13D_HUMAN	ankyrin repeat domain 13 family, member D	219										endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(3)|ovary(1)	9			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			CTGGGGATGGCGCAGCAGCAT	0.687000													27	291					0	0	1	0	0
SERPINB1	1992	broad.mit.edu	37	6	2838132	2838132	+	Silent	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr6:2838132G>A	ENST00000380739.5	-	4	610	c.408C>T	c.(406-408)gtC>gtT	p.V136V	SERPINB1_ENST00000537185.1_5'UTR|SERPINB1_ENST00000476896.1_5'UTR			P30740	ILEU_HUMAN	serpin peptidase inhibitor, clade B (ovalbumin), member 1	136					regulation of proteolysis	cytoplasm|extracellular space	serine-type endopeptidase inhibitor activity			breast(4)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(1)|lung(2)|ovary(2)	13	Ovarian(93;0.0412)			OV - Ovarian serous cystadenocarcinoma(45;0.0717)		TCTGTCCTTTGACCCACTGGT	0.488000													90	936					0	0	1	0	0
MT-ND5	4540	broad.mit.edu	37	MT	13966	13966	+	Missense_Mutation	SNP	A	A	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:13966A>G	ENST00000361567.2	+	1	1630	c.1630A>G	c.(1630-1632)Acg>Gcg	p.T544A				P03915	NU5M_HUMAN	mitochondrially encoded NADH dehydrogenase 5	544					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(4)|endometrium(29)|kidney(33)|pancreas(1)|prostate(7)	74					NADH(DB00157)	TAGGCCTTCTTACGAGCCAAA	0.428000													6	32					0	0	1	0	0
SCGN	10590	broad.mit.edu	37	6	25670278	25670278	+	Nonsense_Mutation	SNP	A	A	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr6:25670278A>T	ENST00000377961.2	+	6	613	c.445A>T	c.(445-447)Aaa>Taa	p.K149*	SCGN_ENST00000334979.6_3'UTR	NM_006998.3	NP_008929.2	O76038	SEGN_HUMAN	secretagogin, EF-hand calcium binding protein	149	EF-hand 4.					extracellular region|transport vesicle membrane	calcium ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	24						TTCTGAGGCTAAACTGGAAGA	0.463000													101	544					0	0	1	0	0
SCGN	10590	broad.mit.edu	37	6	25670281	25670281	+	Missense_Mutation	SNP	C	C	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr6:25670281C>A	ENST00000377961.2	+	6	616	c.448C>A	c.(448-450)Ctg>Atg	p.L150M	SCGN_ENST00000334979.6_3'UTR	NM_006998.3	NP_008929.2	O76038	SEGN_HUMAN	secretagogin, EF-hand calcium binding protein	150	EF-hand 4.					extracellular region|transport vesicle membrane	calcium ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(2)|pancreas(1)|prostate(1)|skin(2)	24						TGAGGCTAAACTGGAAGAATA	0.463000													97	533					2.44874e-31	2.70755e-31	1	1	0
WDR45	11152	broad.mit.edu	37	X	48932556	48932556	+	Nonsense_Mutation	SNP	C	C	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrX:48932556C>T	ENST00000473974.1	-	9	879	c.741G>A	c.(739-741)tgG>tgA	p.W247*	WDR45_ENST00000356463.3_Missense_Mutation_p.G331E|WDR45_ENST00000396681.4_Missense_Mutation_p.G316E|WDR45_ENST00000376358.3_Intron|WDR45_ENST00000376368.2_Missense_Mutation_p.G331E|WDR45_ENST00000376372.3_Missense_Mutation_p.G330E|WDR45_ENST00000322995.8_Missense_Mutation_p.G341E|WDR45_ENST00000485908.1_Missense_Mutation_p.G295E|WDR45_ENST00000470270.1_Intron|WDR45_ENST00000553851.1_Intron			Q9Y484	WIPI4_HUMAN	WD repeat domain 45	247					autophagy|response to starvation	organelle membrane	phosphatidylinositol-3,5-bisphosphate binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(7)|ovary(1)|skin(1)	19						GTGGAAGGTCCCATCTACGCA	0.537000													20	291					0	0	1	0	0
TSNARE1	203062	broad.mit.edu	37	8	143427196	143427196	+	Missense_Mutation	SNP	T	T	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr8:143427196T>G	ENST00000524325.1	-	3	321	c.146A>C	c.(145-147)gAg>gCg	p.E49A	TSNARE1_ENST00000520166.1_Missense_Mutation_p.E49A|TSNARE1_ENST00000307180.3_Missense_Mutation_p.E49A|TSNARE1_ENST00000519651.1_Intron			Q96NA8	TSNA1_HUMAN	t-SNARE domain containing 1	49					vesicle-mediated transport	integral to membrane				breast(1)|endometrium(3)|kidney(4)|large_intestine(1)|lung(6)|ovary(2)|stomach(2)|urinary_tract(1)	20	all_cancers(97;7.39e-11)|all_epithelial(106;8.98e-09)|Lung NSC(106;0.000167)|all_lung(105;0.000332)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					CAGCTTGCTCTCTGGCGACGG	0.597000													22	329					0	0	1	0	0
EML4	27436	broad.mit.edu	37	2	42511790	42511790	+	Missense_Mutation	SNP	G	G	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr2:42511790G>T	ENST00000318522.5	+	9	1220	c.958G>T	c.(958-960)Gac>Tac	p.D320Y	EML4_ENST00000402711.2_Missense_Mutation_p.D262Y|EML4_ENST00000401738.3_Missense_Mutation_p.D331Y	NM_019063.3	NP_061936.2	Q9HC35	EMAL4_HUMAN	echinoderm microtubule associated protein like 4	320					microtubule-based process|mitosis	cytoplasm|microtubule	protein binding		EML4/ALK(543)	NS(2)|breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	12						TATACATCCTGACAAAATTAG	0.378000			T	ALK	NSCLC								43	274					1.23103e-26	1.34474e-26	1	1	0
MESDC1	59274	broad.mit.edu	37	15	81295381	81295381	+	Missense_Mutation	SNP	G	G	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr15:81295381G>T	ENST00000267984.2	+	1	2087	c.769G>T	c.(769-771)Gca>Tca	p.A257S		NM_022566.2	NP_072088.1	Q9H1K6	MESD1_HUMAN	mesoderm development candidate 1	257										endometrium(1)|lung(2)	3						CCTGGTGCAGGCAGTGAGCGC	0.736000													4	40					0.00909568	0.00912924	1	1	0
DSE	29940	broad.mit.edu	37	6	116580008	116580008	+	Silent	SNP	A	A	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr6:116580008A>G	ENST00000540275.1	+	2	523	c.402A>G	c.(400-402)gcA>gcG	p.A134A				Q9UL01	DSE_HUMAN	dermatan sulfate epimerase	63					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)		TTGACGATGCACACAGTCATG	0.552000													7	157					0	0	1	0	0
RHOBTB2	23221	broad.mit.edu	37	8	22864416	22864416	+	Missense_Mutation	SNP	C	C	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr8:22864416C>G	ENST00000251822.6	+	5	1195	c.658C>G	c.(658-660)Cac>Gac	p.H220D	RP11-875O11.1_ENST00000523884.1_RNA|RP11-875O11.1_ENST00000502083.2_RNA|RHOBTB2_ENST00000522948.1_Missense_Mutation_p.H227D|RHOBTB2_ENST00000519685.1_Missense_Mutation_p.H242D	NM_015178.2	NP_055993.2	Q9BYZ6	RHBT2_HUMAN	Rho-related BTB domain containing 2	220					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|plasma membrane	GTP binding			breast(1)|central_nervous_system(1)|endometrium(5)|kidney(1)|large_intestine(6)|lung(11)|ovary(2)|prostate(2)|skin(1)|urinary_tract(1)	31		Prostate(55;0.0513)|Breast(100;0.214)		Colorectal(74;0.0157)|COAD - Colon adenocarcinoma(73;0.064)		CTGGAAGTCCCACCTCCGCAA	0.652000													82	529					0	0	1	0	0
PLB1	151056	broad.mit.edu	37	2	28849295	28849295	+	Splice_Site	SNP	G	G	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr2:28849295G>T	ENST00000422425.2	+	50	3591	c.3546_splice	c.e50-1	p.D1183_splice	PLB1_ENST00000541605.1_Splice_Site_p.D159_splice|PLB1_ENST00000327757.5_Splice_Site_p.D1194_splice	NM_001170585.1	NP_001164056.1	Q6P1J6	PLB1_HUMAN	phospholipase B1	1194	4 X 308-326 AA approximate repeats.				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			NS(2)|breast(1)|central_nervous_system(1)|endometrium(6)|kidney(2)|large_intestine(10)|lung(31)|ovary(6)|prostate(1)|skin(7)|stomach(2)	69	Acute lymphoblastic leukemia(172;0.155)					GTCCCCTCAGGACATCAACCT	0.547000													33	246					3.11337e-16	3.29509e-16	1	1	0
DSE	29940	broad.mit.edu	37	6	116579984	116579984	+	Silent	SNP	C	C	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr6:116579984C>T	ENST00000540275.1	+	2	499	c.378C>T	c.(376-378)gaC>gaT	p.D126D				Q9UL01	DSE_HUMAN	dermatan sulfate epimerase	55					dermatan sulfate biosynthetic process	endoplasmic reticulum|Golgi apparatus|integral to membrane	chondroitin-glucuronate 5-epimerase activity			NS(1)|breast(2)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(12)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(1)	35		all_cancers(87;0.00019)|all_epithelial(87;0.000416)|Ovarian(999;0.133)|Colorectal(196;0.234)		Epithelial(106;0.00915)|OV - Ovarian serous cystadenocarcinoma(136;0.0149)|GBM - Glioblastoma multiforme(226;0.0189)|all cancers(137;0.0262)		AGGTGTATGACCTCGAAGGCA	0.577000													19	178					0	0	1	0	0
MT-ND5	4540	broad.mit.edu	37	MT	14139	14139	+	Silent	SNP	A	A	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:14139A>G	ENST00000361567.2	+	1	1803	c.1803A>G	c.(1801-1803)ctA>ctG	p.L601L				P03915	NU5M_HUMAN	mitochondrially encoded NADH dehydrogenase 5	601					mitochondrial electron transport, NADH to ubiquinone|transport	integral to membrane|mitochondrial respiratory chain complex I	NADH dehydrogenase (ubiquinone) activity			breast(4)|endometrium(29)|kidney(33)|pancreas(1)|prostate(7)	74					NADH(DB00157)	ACCCTACTCCTAATCACATAA	0.398000													4	42					0	0	1	0	0
SCAF8	22828	broad.mit.edu	37	6	155123170	155123170	+	Silent	SNP	C	C	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr6:155123170C>T	ENST00000367178.3	+	7	1248	c.672C>T	c.(670-672)gcC>gcT	p.A224A	SCAF8_ENST00000417268.1_Silent_p.A224A|SCAF8_ENST00000367186.4_Silent_p.A290A	NM_014892.3	NP_055707.3	Q9UPN6	SCAF8_HUMAN	SR-related CTD-associated factor 8	224	Gln-rich.				mRNA processing|RNA splicing	nuclear matrix|spliceosomal complex	nucleotide binding|RNA binding|RNA polymerase core enzyme binding			breast(4)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(14)|lung(15)|ovary(1)|prostate(3)|upper_aerodigestive_tract(1)	46						TTCTGCAGGCCCTAGATGCTG	0.443000													81	276					0	0	1	0	0
WDR83	84292	broad.mit.edu	37	19	12786384	12786384	+	Silent	SNP	G	G	A	rs142130654	by1000genomes	TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr19:12786384G>A	ENST00000418543.3	+	11	1195	c.846G>A	c.(844-846)tcG>tcA	p.S282S	WDR83_ENST00000242796.4_Silent_p.S282S	NM_001099737.2	NP_001093207.1	Q9BRX9	WDR83_HUMAN	WD repeat domain 83	282					nuclear mRNA splicing, via spliceosome	catalytic step 2 spliceosome|cytoplasm				breast(2)|large_intestine(1)|lung(1)	4						TGGTGCAGTCGCTGGCCTACC	0.657000											OREG0025272	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	33	226					0	0	1	0	0
LHB	3972	broad.mit.edu	37	19	49520322	49520322	+	Splice_Site	SNP	A	A	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr19:49520322A>C	ENST00000221421.2	-	1	15		c.e1+1			NM_000894.2	NP_000885.1	P01229	LSHB_HUMAN	luteinizing hormone beta polypeptide						cell-cell signaling|cellular nitrogen compound metabolic process|male gonad development|peptide hormone processing|progesterone biosynthetic process|signal transduction	extracellular region|soluble fraction	hormone activity			cervix(1)|endometrium(1)|large_intestine(1)|lung(4)|prostate(1)	8		all_epithelial(76;9.62e-07)|all_lung(116;1.7e-06)|Lung NSC(112;3.55e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		all cancers(93;0.000371)|OV - Ovarian serous cystadenocarcinoma(262;0.000503)|GBM - Glioblastoma multiforme(486;0.00518)|Epithelial(262;0.0427)	Lutropin alfa(DB00044)|Menotropins(DB00032)	CTGTAGTCTTACCTGGAGCAT	0.602000													80	921					0	0	1	0	0
CSPP1	79848	broad.mit.edu	37	8	68062034	68062034	+	Missense_Mutation	SNP	G	G	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr8:68062034G>C	ENST00000262210.5	+	16	2008	c.1977G>C	c.(1975-1977)atG>atC	p.M659I	CSPP1_ENST00000412460.1_Intron	NM_024790.6	NP_079066.5	Q1MSJ5	CSPP1_HUMAN	centrosome and spindle pole associated protein 1	694						centrosome|microtubule|spindle				NS(1)|breast(3)|endometrium(4)|kidney(3)|large_intestine(11)|lung(17)|ovary(5)|prostate(3)|skin(1)|urinary_tract(1)	49	Breast(64;0.214)	Lung NSC(129;0.0908)|all_lung(136;0.152)	Epithelial(68;0.00145)|OV - Ovarian serous cystadenocarcinoma(28;0.00589)|all cancers(69;0.0069)|BRCA - Breast invasive adenocarcinoma(89;0.153)			TGAATAGGATGCACAGACAAA	0.328000													111	851					0	0	1	0	0
ZSWIM5	57643	broad.mit.edu	37	1	45486422	45486422	+	Missense_Mutation	SNP	G	G	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr1:45486422G>T	ENST00000359600.5	-	12	2693	c.2488C>A	c.(2488-2490)Cag>Aag	p.Q830K		NM_020883.1	NP_065934.1	Q9P217	ZSWM5_HUMAN	zinc finger, SWIM-type containing 5	830							zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(2)|kidney(3)|large_intestine(2)|liver(1)|lung(13)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	28	Acute lymphoblastic leukemia(166;0.155)					ATGTGCTTCTGTATTGCTTCC	0.448000													160	990					4.16832e-71	4.66577e-71	1	1	0
CTC-457E21.3	0	broad.mit.edu	37	19	22785299	22785299	+	RNA	SNP	T	T	G	rs11670278	by1000genomes	TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr19:22785299T>G	ENST00000600260.1	+	0	1475					NR_033899.1																						CCCTGCAGGGTGCCATGGAGA	0.632000													8	121					0	0	1	0	0
KLK8	11202	broad.mit.edu	37	19	51503919	51503919	+	Silent	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr19:51503919G>A	ENST00000391806.2	-	3	206	c.126C>T	c.(124-126)gtC>gtT	p.V42V	KLK8_ENST00000593490.1_Intron|CTB-147C22.9_ENST00000594512.1_RNA|KLK9_ENST00000376832.4_Intron|KLK9_ENST00000250366.6_Intron|KLK8_ENST00000600767.1_Intron|KLK8_ENST00000320838.5_Intron|KLK8_ENST00000291726.7_Intron|KLK8_ENST00000347619.4_Intron			O60259	KLK8_HUMAN	kallikrein-related peptidase 8	23	Peptidase S1.				cell death|keratinocyte proliferation|memory|negative regulation of axon regeneration|negative regulation of myelination|neuron projection morphogenesis|proteolysis|regulation of synapse organization|response to wounding	cytoplasm|extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|lung(8)|prostate(1)	15		all_neural(266;0.026)		OV - Ovarian serous cystadenocarcinoma(262;0.0033)|GBM - Glioblastoma multiforme(134;0.00888)		GGTTCAAATGGACACACGGCA	0.587000													38	401					0	0	1	0	0
DYM	54808	broad.mit.edu	37	18	46783384	46783384	+	Missense_Mutation	SNP	T	T	A	rs61758455		TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr18:46783384T>A	ENST00000269445.6	-	13	1913	c.1456A>T	c.(1456-1458)Atc>Ttc	p.I486F	DYM_ENST00000442713.2_Missense_Mutation_p.I296F	NM_017653.3	NP_060123.3	Q7RTS9	DYM_HUMAN	dymeclin	486						Golgi apparatus				NS(1)|cervix(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(6)|skin(1)|upper_aerodigestive_tract(1)	18						ATTTACCTGATGATCCTCTGG	0.403000													34	181					0	0	1	0	0
MT-ND4	4538	broad.mit.edu	37	MT	12007	12007	+	Nonsense_Mutation	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:12007G>A	ENST00000361381.2	+	1	1248	c.1248G>A	c.(1246-1248)tgG>tgA	p.416_416ins*						mitochondrially encoded NADH dehydrogenase 4											breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|prostate(1)	13						ACAACACAATGGGGCTCACTC	0.448000													5	68					0	0	1	0	0
BSX	390259	broad.mit.edu	37	11	122850021	122850021	+	Missense_Mutation	SNP	G	G	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr11:122850021G>C	ENST00000343035.2	-	2	455	c.407C>G	c.(406-408)tCc>tGc	p.S136C		NM_001098169.1	NP_001091639.1	Q3C1V8	BSH_HUMAN	brain-specific homeobox	136										endometrium(1)|kidney(1)|large_intestine(3)|lung(3)|prostate(2)	10		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0361)		TTCTGGCGTGGACAGGTAGCG	0.657000													24	459					0	0	1	0	0
TRAV16	0	broad.mit.edu	37	14	22458938	22458938	+	RNA	SNP	C	C	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr14:22458938C>T	ENST00000390444.1	+	0	90																											AGAAGCTCCTCTCTGTCTTTA	0.483000													16	77					0	0	1	0	0
MT-CO1	4512	broad.mit.edu	37	MT	6827	6827	+	Missense_Mutation	SNP	T	T	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:6827T>C	ENST00000361624.2	+	1	924	c.924T>C	c.(922-924)gcT>gcC	p.308_308insA						mitochondrially encoded cytochrome c oxidase I											breast(4)|endometrium(25)|kidney(19)|lung(3)|prostate(3)	54						TTCACCTCCGCTACCATAATC	0.463000													5	77					0	0	1	0	0
NLRP5	126206	broad.mit.edu	37	19	56565133	56565133	+	Silent	SNP	C	C	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr19:56565133C>T	ENST00000390649.3	+	13	3258	c.3258C>T	c.(3256-3258)tgC>tgT	p.C1086C		NM_153447.4	NP_703148.4	P59047	NALP5_HUMAN	NLR family, pyrin domain containing 5	1086						mitochondrion|nucleolus	ATP binding			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(8)|ovary(5)|skin(2)|stomach(4)|upper_aerodigestive_tract(2)	25		Colorectal(82;3.46e-05)|Ovarian(87;0.0481)|Renal(1328;0.157)		GBM - Glioblastoma multiforme(193;0.0326)		CTGCGCTGTGCGAGGGACTGA	0.622000													47	308					0	0	1	0	0
AC016995.3	0	broad.mit.edu	37	2	38709678	38709678	+	RNA	SNP	C	C	T	rs148735877	by1000genomes	TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr2:38709678C>T	ENST00000417039.1	-	0	696																											TGTCTGCAGACTGGCTACCCA	0.512000													39	288					0	0	1	0	0
ARID2	196528	broad.mit.edu	37	12	46245520	46245520	+	Missense_Mutation	SNP	G	G	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr12:46245520G>C	ENST00000334344.6	+	15	3786	c.3614G>C	c.(3613-3615)gGa>gCa	p.G1205A	ARID2_ENST00000479608.1_3'UTR|ARID2_ENST00000422737.1_Missense_Mutation_p.G1056A|ARID2_ENST00000444670.1_Missense_Mutation_p.G815A	NM_152641.2	NP_689854.2	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	1205					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			NS(1)|autonomic_ganglia(1)|breast(7)|central_nervous_system(3)|cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(21)|liver(20)|lung(34)|ovary(7)|pancreas(1)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(2)	116	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		ACCATGAGCGGAACGCAGACA	0.483000			"""N, S, F"""		hepatocellular carcinoma								50	249					0	0	1	0	0
UBE2Q1	55585	broad.mit.edu	37	1	154525225	154525225	+	Missense_Mutation	SNP	C	C	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr1:154525225C>G	ENST00000292211.4	-	6	880	c.801G>C	c.(799-801)caG>caC	p.Q267H	UBE2Q1_ENST00000497453.1_5'UTR	NM_017582.6	NP_060052.3	Q7Z7E8	UB2Q1_HUMAN	ubiquitin-conjugating enzyme E2Q family member 1	267							ATP binding|protein binding|ubiquitin-protein ligase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(3)|lung(6)|upper_aerodigestive_tract(1)	16	all_lung(78;1.72e-29)|Lung NSC(65;2.96e-27)|Hepatocellular(266;0.0877)|all_hematologic(923;0.088)		LUSC - Lung squamous cell carcinoma(543;0.185)			CTTTGAAACTCTGTGATCGGT	0.572000													20	465					0	0	1	0	0
CTD-2066L21.3	0	broad.mit.edu	37	5	33162435	33162435	+	RNA	SNP	A	A	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr5:33162435A>G	ENST00000510327.1	-	0	346																											TGTGCAGGGAAGTAACAAGAA	0.537000													13	265					0	0	1	0	0
CELA3A	10136	broad.mit.edu	37	1	22331987	22331987	+	Silent	SNP	C	C	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr1:22331987C>T	ENST00000290122.3	+	3	196	c.177C>T	c.(175-177)ggC>ggT	p.G59G	CELA3A_ENST00000374663.1_Silent_p.G59G	NM_005747.4	NP_005738.4			chymotrypsin-like elastase family, member 3A											endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(8)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						ACACGTGTGGCGGTAGCCTCA	0.622000											OREG0013211	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	51	504					0	0	1	0	0
ZHX1	11244	broad.mit.edu	37	8	124267697	124267697	+	Missense_Mutation	SNP	C	C	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr8:124267697C>T	ENST00000395571.3	-	3	1107	c.490G>A	c.(490-492)Gag>Aag	p.E164K	ZHX1_ENST00000522655.1_Missense_Mutation_p.E164K|ZHX1-C8ORF76_ENST00000357082.4_Intron|ZHX1_ENST00000297857.2_Missense_Mutation_p.E164K	NM_001017926.2|NM_007222.4	NP_001017926.1|NP_009153.3	Q9UKY1	ZHX1_HUMAN	zinc fingers and homeoboxes 1	164					negative regulation of transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(3)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(6)|liver(1)|lung(5)|ovary(1)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	29	Lung NSC(37;1.25e-09)|Ovarian(258;0.0154)		STAD - Stomach adenocarcinoma(47;0.00527)			TCTGCTTGCTCTGCATTCTCC	0.323000													29	636					0	0	1	0	0
MT-CO2	4513	broad.mit.edu	37	MT	8027	8027	+	Missense_Mutation	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:8027G>A	ENST00000361739.1	+	1	442	c.442G>A	c.(442-444)Gcc>Acc	p.A148T						mitochondrially encoded cytochrome c oxidase II											endometrium(5)|kidney(8)|lung(2)|pancreas(3)|prostate(1)	19						TCCCGATTGAAGCCCCCATTC	0.468000													11	85					0	0	1	0	0
NEK10	152110	broad.mit.edu	37	3	27297832	27297832	+	Missense_Mutation	SNP	T	T	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr3:27297832T>C	ENST00000429845.2	-	24	2407	c.2045A>G	c.(2044-2046)gAa>gGa	p.E682G	NEK10_ENST00000357467.2_Missense_Mutation_p.E79G|NEK10_ENST00000341435.5_Missense_Mutation_p.E682G			Q6ZWH5	NEK10_HUMAN	NIMA-related kinase 10	682	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			NS(2)|breast(1)|central_nervous_system(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(9)|ovary(5)|pancreas(1)|prostate(1)|skin(4)|stomach(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	41						TTTACTGTTTTCTTGTTTTTG	0.358000													12	117					0	0	1	0	0
NTMT1	28989	broad.mit.edu	37	9	132395107	132395107	+	Missense_Mutation	SNP	T	T	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr9:132395107T>A	ENST00000372486.1	+	2	474	c.125T>A	c.(124-126)aTc>aAc	p.I42N	NTMT1_ENST00000482347.1_Intron|NTMT1_ENST00000372483.4_Missense_Mutation_p.I42N|NTMT1_ENST00000459968.2_Missense_Mutation_p.I42N|NTMT1_ENST00000486391.2_Intron|NTMT1_ENST00000372480.1_Missense_Mutation_p.I42N|NTMT1_ENST00000372481.3_Missense_Mutation_p.I42N					N-terminal Xaa-Pro-Lys N-methyltransferase 1																		AGCATCGACATCAACAGCTCC	0.567000													108	569					0	0	1	0	0
STK4	6789	broad.mit.edu	37	20	43703792	43703792	+	Missense_Mutation	SNP	A	A	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr20:43703792A>T	ENST00000372806.3	+	11	1534	c.1439A>T	c.(1438-1440)aAg>aTg	p.K480M	STK4_ENST00000372801.1_3'UTR|STK4_ENST00000499879.2_Missense_Mutation_p.K425M	NM_006282.2	NP_006273.1	Q13043	STK4_HUMAN	serine/threonine kinase 4	480	SARAH.				apoptosis|cell morphogenesis|hippo signaling cascade|intracellular protein kinase cascade|negative regulation of canonical Wnt receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of apoptosis|protein autophosphorylation	cytoplasm|nucleus	ATP binding|magnesium ion binding|protein homodimerization activity|protein serine/threonine kinase activator activity|protein serine/threonine kinase activity|transcription factor binding			NS(1)|breast(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|liver(2)|lung(5)|ovary(1)|prostate(1)|skin(2)	20		Myeloproliferative disorder(115;0.0122)				ATAGAGGCTAAGAAGAGACGG	0.562000													10	211					0	0	1	0	0
OR6Y1	391112	broad.mit.edu	37	1	158517108	158517108	+	Missense_Mutation	SNP	G	G	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr1:158517108G>T	ENST00000302617.3	-	1	787	c.788C>A	c.(787-789)aCc>aAc	p.T263N		NM_001005189.1	NP_001005189.1	Q8NGX8	OR6Y1_HUMAN	olfactory receptor, family 6, subfamily Y, member 1	263					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|kidney(1)|large_intestine(5)|lung(16)|ovary(1)|prostate(2)|upper_aerodigestive_tract(2)|urinary_tract(2)	30	all_hematologic(112;0.0378)					ACGGGCATAGGTGAAAAGTGT	0.483000													98	608					9.86815e-39	1.09557e-38	1	1	0
AC009499.1	0	broad.mit.edu	37	2	33952621	33952621	+	RNA	SNP	G	G	A	rs11684598	by1000genomes	TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr2:33952621G>A	ENST00000366209.2	+	0	68				MYADML_ENST00000474610.1_RNA																							CTTCGGTGGCGTAAGCCACAC	0.647000													6	153					0	0	1	0	0
CTSF	8722	broad.mit.edu	37	11	66331559	66331559	+	Splice_Site	SNP	C	C	T			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr11:66331559C>T	ENST00000310325.5	-	12	1489	c.1380_splice	c.e12+1	p.K460_splice		NM_003793.3	NP_003784.2	Q9UBX1	CATF_HUMAN	cathepsin F	460				SDVPFWAIKNSWGTDWGEKGYYYLHRGSGACGVNTMASSAV VD -> EFRCLSCIQPGHRQGWDHSISGPLEGK (in Ref. 9).	proteolysis	lysosome	cysteine-type endopeptidase activity			endometrium(1)|large_intestine(7)|lung(8)|ovary(1)|stomach(1)|upper_aerodigestive_tract(1)	19						CAAGACTCACCTTCTCACCCC	0.612000													14	112					0	0	1	0	0
FAM180A	389558	broad.mit.edu	37	7	135418815	135418815	+	Missense_Mutation	SNP	G	G	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr7:135418815G>C	ENST00000338588.3	-	3	695	c.430C>G	c.(430-432)Cag>Gag	p.Q144E	FAM180A_ENST00000415751.1_Missense_Mutation_p.Q144E	NM_205855.3	NP_995327.1	Q6UWF9	F180A_HUMAN	family with sequence similarity 180, member A	144						extracellular region				endometrium(1)|kidney(2)|large_intestine(2)|lung(6)|ovary(2)|pancreas(1)	14						ATGTCCTTCTGATGGCCGTGG	0.607000													39	281					0	0	1	0	0
MT-RNR2	0	broad.mit.edu	37	MT	1888	1888	+	RNA	SNP	G	G	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrM:1888G>A	ENST00000387347.2	+	0	218					NR_039705.1																						TTTGCAAGGAGAGCCAAAGCT	0.398000													14	110					0	0	1	0	0
C19orf59	199675	broad.mit.edu	37	19	7743463	7743463	+	Missense_Mutation	SNP	A	A	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr19:7743463A>G	ENST00000333598.3	+	5	914	c.460A>G	c.(460-462)Att>Gtt	p.I154V	CTD-3214H19.16_ENST00000597959.1_Missense_Mutation_p.D26G|C19orf59_ENST00000597445.1_Missense_Mutation_p.I111V	NM_174918.2	NP_777578.2	Q8IX19	MCEM1_HUMAN	chromosome 19 open reading frame 59	154						integral to membrane				endometrium(1)|lung(2)|skin(1)|stomach(1)	5						CAGGAGCAAGATTGATAGATT	0.522000											OREG0025208	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	43	236					0	0	1	0	0
TIMP1	7076	broad.mit.edu	37	X	47446054	47446054	+	Silent	SNP	G	G	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrX:47446054G>C	ENST00000218388.4	+	6	758	c.588G>C	c.(586-588)ctG>ctC	p.L196L	SYN1_ENST00000295987.7_Intron|TIMP1_ENST00000377017.1_Silent_p.L132L|SYN1_ENST00000340666.4_Intron	NM_003254.2	NP_003245.1	P01033	TIMP1_HUMAN	TIMP metallopeptidase inhibitor 1	196					erythrocyte maturation|negative regulation of membrane protein ectodomain proteolysis|platelet activation|platelet degranulation|positive regulation of cell proliferation	platelet alpha granule lumen	metal ion binding|metalloendopeptidase inhibitor activity|protein binding			endometrium(1)|large_intestine(2)	3						AGCCAGGGCTGTGCACCTGGC	0.612000													12	201					0	0	1	0	0
BRD4	23476	broad.mit.edu	37	19	15354198	15354198	+	Missense_Mutation	SNP	C	C	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr19:15354198C>G	ENST00000263377.2	-	14	2903	c.2682G>C	c.(2680-2682)ttG>ttC	p.L894F		NM_058243.2	NP_490597.1	O60885	BRD4_HUMAN	bromodomain containing 4	894					interspecies interaction between organisms|positive regulation of G2/M transition of mitotic cell cycle|positive regulation of transcription elongation from RNA polymerase II promoter|regulation of transcription involved in G1 phase of mitotic cell cycle	condensed nuclear chromosome|cytoplasm	protein binding			breast(1)|cervix(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(2)|lung(7)|ovary(2)|urinary_tract(1)	21			OV - Ovarian serous cystadenocarcinoma(3;3.02e-24)|Epithelial(3;4.71e-20)|all cancers(3;2.26e-18)			GTGTTTGGGTCAAGGCTGGTG	0.682000			T	C15orf55	lethal midline carcinoma of young people								5	65					0	0	1	0	0
CDCP2	200008	broad.mit.edu	37	1	54605517	54605517	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr1:54605517delT	ENST00000371330.1	-	4	1873	c.1026delA	c.(1024-1026)ccfs	p.P343fs	CDCP2_ENST00000530059.1_5'UTR	NM_201546.2	NP_963840.2	Q5VXM1	CDCP2_HUMAN	CUB domain containing protein 2	343	CUB 3.					extracellular region				kidney(1)|large_intestine(6)|lung(13)|ovary(1)|prostate(2)|stomach(1)	24						AGGTCACGGGTGGTGGCAGGT	0.632													43	270	---	---	---	---					
KCNC4	3749	broad.mit.edu	37	1	110768648	110768664	+	Frame_Shift_Del	DEL	CTGGCCTCACCCAACCC	CTGGCCTCACCCAACCC	-			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr1:110768648_110768664delCTGGCCTCACCCAACCC	ENST00000369787.3	+	3	1694_1710	c.1667_1683delCTGGCCTCACCCAACCC	c.(1666-1683)gfs	p.AGLTQP556fs	KCNC4_ENST00000438661.2_Frame_Shift_Del_p.AGLTQP556fs|KCNC4_ENST00000413138.3_Frame_Shift_Del_p.AGLTQP556fs|KCNC4_ENST00000412512.2_Intron	NM_004978.4	NP_004969.2	Q03721	KCNC4_HUMAN	potassium voltage-gated channel, Shaw-related subfamily, member 4	556					synaptic transmission	voltage-gated potassium channel complex	voltage-gated potassium channel activity			central_nervous_system(1)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(3)|liver(2)|lung(11)|ovary(1)|skin(2)	32		all_cancers(81;9.88e-06)|all_epithelial(167;3.23e-06)|all_lung(203;0.000116)|Lung NSC(277;0.000233)		Lung(183;0.0238)|all cancers(265;0.0693)|Epithelial(280;0.0748)|Colorectal(144;0.112)|LUSC - Lung squamous cell carcinoma(189;0.135)		GAGGAGGGAGCTGGCCTCACCCAACCCCTGGCCTCCT	0.641													51	300	---	---	---	---					
SRGAP2B	0	broad.mit.edu	37	1	144043905	144043906	+	RNA	INS	-	-	G			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr1:144043905_144043906insG	ENST00000467933.1	+	0	1108																											tcgctcacgctggagctgtaga	0.535													9	91	---	---	---	---					
OTUD7B	56957	broad.mit.edu	37	1	149920861	149920869	+	Splice_Site	DEL	CCTGGCTTA	CCTGGCTTA	-			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr1:149920861_149920869delCCTGGCTTA	ENST00000369135.3	-	10	1533		c.e10+1			NM_020205.2	NP_064590.2	Q6GQQ9	OTU7B_HUMAN	OTU domain containing 7B						negative regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|microtubule cytoskeleton|nucleus	cysteine-type peptidase activity|DNA binding|protein binding|zinc ion binding			breast(1)|endometrium(6)|kidney(2)|large_intestine(5)|lung(18)|ovary(1)|prostate(2)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	39	Breast(34;0.0009)|Ovarian(49;0.0265)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)|STAD - Stomach adenocarcinoma(528;0.247)			AAAGACTAGGCCTGGCTTACCTGGCCAAT	0.498													26	353	---	---	---	---					
RPL31P11	0	broad.mit.edu	37	1	161654767	161654768	+	RNA	INS	-	-	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr1:161654767_161654768insC	ENST00000426558.1	-	0	274_275					NR_002595.1																						TATGGGACATTCTTATTCCTTT	0.465													7	192	---	---	---	---					
IPO9	55705	broad.mit.edu	37	1	201843998	201844000	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr1:201843998_201844000delGAG	ENST00000361565.4	+	22	2941_2943	c.2872_2874delGAG	c.(2872-2874)del	p.E962del		NM_018085.4	NP_060555.2	Q96P70	IPO9_HUMAN	importin 9	962					protein import into nucleus	cytoplasm|nucleus	histone binding|protein transporter activity			cervix(1)|endometrium(5)|kidney(4)|large_intestine(5)|lung(16)|ovary(2)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	38						ggaggaggaagaggaggaggagg	0.443													8	602	---	---	---	---					
PIK3C2B	5287	broad.mit.edu	37	1	204438072	204438072	+	Frame_Shift_Del	DEL	G	G	-	rs115574296	by1000genomes	TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr1:204438072delG	ENST00000367187.3	-	3	1415	c.859delC	c.(859-861)gcfs	p.R287fs	PIK3C2B_ENST00000424712.2_Frame_Shift_Del_p.R287fs	NM_002646.3	NP_002637.3	O00750	P3C2B_HUMAN	phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta	287	Interaction with GRB2.				cell communication|phosphatidylinositol-mediated signaling	endoplasmic reticulum|microsome|nucleus|phosphatidylinositol 3-kinase complex|plasma membrane	1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol binding|phosphatidylinositol-4-phosphate 3-kinase activity|protein binding	p.R287fs*92(1)		breast(3)|central_nervous_system(1)|cervix(2)|endometrium(4)|large_intestine(11)|lung(24)|prostate(3)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	52	all_cancers(21;0.00347)|all_neural(3;0.0218)|Glioma(3;0.0382)|all_epithelial(62;0.171)|Breast(84;0.179)|Prostate(682;0.227)		GBM - Glioblastoma multiforme(2;2.69e-45)|all cancers(3;1.66e-30)|KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)|Epithelial(59;0.193)			GCATAGGTGCGGGGGGGCACC	0.622													8	699	---	---	---	---					
HIBCH	26275	broad.mit.edu	37	2	191161629	191161629	+	Frame_Shift_Del	DEL	T	T	-			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr2:191161629delT	ENST00000392332.3	-	3	268	c.129delA	c.(127-129)aafs	p.K43fs	HIBCH_ENST00000359678.5_Frame_Shift_Del_p.K43fs			Q6NVY1	HIBCH_HUMAN	3-hydroxyisobutyryl-CoA hydrolase	43					branched chain family amino acid catabolic process	mitochondrial matrix	3-hydroxyisobutyryl-CoA hydrolase activity|protein binding			NS(1)|breast(2)|endometrium(1)|large_intestine(1)|lung(5)|skin(1)|soft_tissue(1)|upper_aerodigestive_tract(1)	13			OV - Ovarian serous cystadenocarcinoma(117;0.000586)|Epithelial(96;0.0286)|all cancers(119;0.0814)			CCGTGCAACCTTTTTTTTCCA	0.353													7	339	---	---	---	---					
ERC2	26059	broad.mit.edu	37	3	55733470	55733472	+	In_Frame_Del	DEL	TGG	TGG	-			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr3:55733470_55733472delTGG	ENST00000288221.6	-	16	3036_3038	c.2781_2783delCCA	c.(2779-2784)cat>ca	p.HH931del		NM_015576.1	NP_056391.1	O15083	ERC2_HUMAN	ELKS/RAB6-interacting/CAST family member 2	931	Poly-His.					cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			breast(2)|endometrium(5)|large_intestine(6)|liver(1)|lung(14)|ovary(2)|urinary_tract(1)	31				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		gtggtggtgatggtggtggtggt	0.502													11	1103	---	---	---	---					
VGLL3	389136	broad.mit.edu	37	3	87027857	87027859	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr3:87027857_87027859delCTC	ENST00000398399.2	-	2	583_585	c.220_222delGAG	c.(220-222)del	p.E74del	VGLL3_ENST00000383698.3_In_Frame_Del_p.E74del	NM_016206.2	NP_057290.2	A8MV65	VGLL3_HUMAN	vestigial like 3 (Drosophila)	74					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				NS(1)|breast(1)|endometrium(4)|large_intestine(2)|lung(11)	19	all_cancers(8;0.109)|Lung SC(3;0.184)	Lung NSC(201;0.0777)		LUSC - Lung squamous cell carcinoma(29;0.00241)|Lung(72;0.00712)		GCTGGtctttctcctcctcctcc	0.502													7	324	---	---	---	---					
GOLIM4	27333	broad.mit.edu	37	3	167747642	167747644	+	In_Frame_Del	DEL	CTG	CTG	-	rs61743912	byFrequency	TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr3:167747642_167747644delCTG	ENST00000470487.1	-	10	2046_2048	c.1357_1359delCAG	c.(1357-1359)del	p.Q453del	GOLIM4_ENST00000309027.4_In_Frame_Del_p.Q425del	NM_014498.3	NP_055313.1	O00461	GOLI4_HUMAN	golgi integral membrane protein 4	453	Gln-rich.|Glu-rich.				transport	cis-Golgi network|endocytic vesicle|endosome membrane|Golgi cisterna membrane|Golgi lumen|integral to membrane|nucleus				breast(5)|endometrium(2)|large_intestine(8)|lung(26)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	47						CTCTTGCCACctgctgctgctgc	0.640													7	289	---	---	---	---					
ZNF876P	0	broad.mit.edu	37	4	212236	212236	+	RNA	DEL	A	A	-	rs80061878		TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr4:212236delA	ENST00000356347.3	+	0	172					NR_027481.1																						ctaaaaatacaaaaaaaaaaa	0.493													5	9	---	---	---	---					
FAT4	79633	broad.mit.edu	37	4	126408614	126408614	+	Frame_Shift_Del	DEL	A	A	-			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr4:126408614delA	ENST00000394329.3	+	16	12944	c.12931delA	c.(12931-12933)aafs	p.K4311fs	FAT4_ENST00000335110.5_Frame_Shift_Del_p.K2552fs	NM_024582.4	NP_078858.4	Q6V0I7	FAT4_HUMAN	FAT atypical cadherin 4	4311	Laminin G-like 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						TCTAATTGGGAAAAATGGAAC	0.403													8	677	---	---	---	---					
CTD-2066L21.3	0	broad.mit.edu	37	5	33162470	33162470	+	RNA	DEL	G	G	-			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr5:33162470delG	ENST00000510327.1	-	0	346																											GGTTGGACGTGGGGGAATTTC	0.527													23	327	---	---	---	---					
CTD-2066L21.3	0	broad.mit.edu	37	5	33162627	33162627	+	RNA	DEL	T	T	-			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr5:33162627delT	ENST00000510327.1	-	0	346																											AGTGGTAAGATGTCCCACTAC	0.473													10	181	---	---	---	---					
PPARGC1B	133522	broad.mit.edu	37	5	149216457	149216459	+	In_Frame_Del	DEL	GGA	GGA	-			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr5:149216457_149216459delGGA	ENST00000309241.5	+	8	2471_2473	c.2439_2441delGGA	c.(2437-2442)ggg>gg	p.GE813del	PPARGC1B_ENST00000403750.1_In_Frame_Del_p.GE749del|PPARGC1B_ENST00000394320.3_In_Frame_Del_p.GE813del|PPARGC1B_ENST00000360453.4_In_Frame_Del_p.GE774del	NM_133263.3	NP_573570.3	Q86YN6	PRGC2_HUMAN	peroxisome proliferator-activated receptor gamma, coactivator 1 beta	813	Glu-rich.				estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter	mediator complex	AF-2 domain binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|nucleotide binding|receptor activator activity|RNA binding|RNA polymerase II transcription cofactor activity			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(1)|liver(2)|lung(15)|ovary(3)|prostate(2)|stomach(1)	30			KIRC - Kidney renal clear cell carcinoma(527;0.000962)|Kidney(363;0.00147)			aggaagaaggggaggaggaggag	0.606													13	539	---	---	---	---					
GCM1	8521	broad.mit.edu	37	6	52996784	52996811	+	Splice_Site	DEL	TAACTAACTCAAAAATCCAACCTGGAAA	TAACTAACTCAAAAATCCAACCTGGAAA	-			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr6:52996784_52996811delTAACTAACTCAAAAATCCAACCTGGAAA	ENST00000259803.7	-	4	646_653	c.441_splice	c.e4+1	p.F145_splice		NM_003643.3	NP_003634.2	Q9NP62	GCM1_HUMAN	glial cells missing homolog 1 (Drosophila)	145						transcription factor complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding	p.?(1)		central_nervous_system(1)|endometrium(2)|kidney(1)|large_intestine(2)|liver(1)|lung(15)|ovary(1)|skin(1)	24	Lung NSC(77;0.0755)					AACTCTCACGTAACTAACTCAAAAATCCAACCTGGAAAAATATAAAGC	0.518													8	161	---	---	---	---					
KLHL38	340359	broad.mit.edu	37	8	124664765	124664792	+	Frame_Shift_Del	DEL	GCTGGGGGCCAACTGGCTCTGCAAGTAC	GCTGGGGGCCAACTGGCTCTGCAAGTAC	-	rs7387544	by1000genomes	TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr8:124664765_124664792delGCTGGGGGCCAACTGGCTCTGCAAGTAC	ENST00000325995.7	-	1	398_425	c.375_402delGTACTTGCAGAGCCAGTTGGCCCCCAGC	c.(373-402)tcfs	p.SYLQSQLAPS125fs	CTD-2552K11.2_ENST00000524355.1_RNA	NM_001081675.2	NP_001075144.2	Q2WGJ6	KLH38_HUMAN	kelch-like family member 38	125								p.S134R(1)		breast(1)|central_nervous_system(1)|endometrium(3)|kidney(3)|large_intestine(9)|lung(16)|pancreas(1)|prostate(3)|stomach(1)	38						CCAGGCAGTTGCTGGGGGCCAACTGGCTCTGCAAGTACGAGGAGCAGG	0.575													15	279	---	---	---	---					
NLRP6	171389	broad.mit.edu	37	11	281553	281555	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr11:281553_281555delGAG	ENST00000534750.1	+	4	2024_2026	c.1819_1821delGAG	c.(1819-1821)del	p.E611del	NLRP6_ENST00000312165.5_In_Frame_Del_p.E611del	NM_001276700.1	NP_001263629.1	P59044	NALP6_HUMAN	NLR family, pyrin domain containing 6	611	Poly-Glu.					cytoplasm	ATP binding			breast(1)|skin(1)|upper_aerodigestive_tract(2)	4		all_cancers(49;1.12e-06)|all_epithelial(84;0.000375)|Breast(177;0.00122)|Ovarian(85;0.0228)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.28e-28)|Epithelial(43;2.47e-27)|OV - Ovarian serous cystadenocarcinoma(40;4.66e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.0485)|LUSC - Lung squamous cell carcinoma(625;0.122)		CGAAGAGCCAGAGGAGGAGGAGG	0.670													7	563	---	---	---	---					
RARRES3	5920	broad.mit.edu	37	11	63313709	63313709	+	Frame_Shift_Del	DEL	A	A	-			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr11:63313709delA	ENST00000255688.3	+	4	524	c.476delA	c.(475-477)cafs	p.Q159fs	RARRES3_ENST00000354445.2_Frame_Shift_Del_p.Q159fs|RARRES3_ENST00000537871.1_3'UTR	NM_004585.3	NP_004576.2	Q9UL19	TIG3_HUMAN	retinoic acid receptor responder (tazarotene induced) 3	159					lipid catabolic process|negative regulation of cell proliferation		hydrolase activity			kidney(1)|large_intestine(1)|lung(2)|ovary(1)|upper_aerodigestive_tract(1)	6						AGGAGATACCAAAAAAAAGCG	0.537													7	758	---	---	---	---					
SSH3	54961	broad.mit.edu	37	11	67076881	67076899	+	Frame_Shift_Del	DEL	TTGAACATGGCCCGGGAGA	TTGAACATGGCCCGGGAGA	-	rs74859815	by1000genomes	TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr11:67076881_67076899delTTGAACATGGCCCGGGAGA	ENST00000308127.4	+	11	1253_1271	c.1075_1093delTTGAACATGGCCCGGGAGA	c.(1075-1095)ttfs	p.LNMAREI359fs	SSH3_ENST00000532181.1_3'UTR|SSH3_ENST00000376757.5_Frame_Shift_Del_p.LNMAREI359fs|SSH3_ENST00000308298.7_Intron	NM_017857.3	NP_060327.3	Q8TE77	SSH3_HUMAN	slingshot protein phosphatase 3	359	Tyrosine-protein phosphatase.				regulation of actin polymerization or depolymerization|regulation of axonogenesis|regulation of lamellipodium assembly	cytoplasm|cytoskeleton|nucleus	actin binding|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			NS(1)|breast(2)|cervix(1)|kidney(1)|large_intestine(3)|lung(6)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	19			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)			CACCCACATCTTGAACATGGCCCGGGAGATTGACAACTT	0.635													24	415	---	---	---	---					
MRPL48	51642	broad.mit.edu	37	11	73555970	73555980	+	Frame_Shift_Del	DEL	CCCAGTATGTT	CCCAGTATGTT	-			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr11:73555970_73555980delCCCAGTATGTT	ENST00000314282.7	+	2	1374_1384	c.23_33delCCCAGTATGTT	c.(22-33)gfs	p.AQYV8fs	MRPL48_ENST00000411840.2_Frame_Shift_Del_p.AQYV8fs|MRPL48_ENST00000310614.7_Frame_Shift_Del_p.AQYV107fs|MRPL48_ENST00000535529.1_Frame_Shift_Del_p.AQYV89fs|MRPL48_ENST00000542303.1_Intron|MRPL48_ENST00000398483.3_Frame_Shift_Del_p.AQYV8fs			Q96GC5	RM48_HUMAN	mitochondrial ribosomal protein L48	107					translation	mitochondrial ribosome	protein binding|structural constituent of ribosome			kidney(1)	1						GAGAGTTATGCCCAGTATGTTCACAACCTCT	0.403													40	241	---	---	---	---					
PHC1	1911	broad.mit.edu	37	12	9087018	9087032	+	In_Frame_Del	DEL	ATTCTCACCCACATC	ATTCTCACCCACATC	-			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr12:9087018_9087032delATTCTCACCCACATC	ENST00000433083.2	+	9	2207_2221	c.2062_2076delATTCTCACCCACATC	c.(2062-2076)del	p.ILTHI688del	PHC1_ENST00000544916.1_In_Frame_Del_p.ILTHI733del|PHC1_ENST00000536844.1_In_Frame_Del_p.ILTHI339del|PHC1_ENST00000543824.1_In_Frame_Del_p.ILTHI733del			P78364	PHC1_HUMAN	polyhomeotic homolog 1 (Drosophila)	733					multicellular organismal development	PcG protein complex	DNA binding|zinc ion binding			breast(2)|cervix(1)|endometrium(5)|large_intestine(8)|liver(2)|lung(3)|ovary(2)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	27						GAAGCCCCAGATTCTCACCCACATCATTGAAGGCT	0.544													8	507	---	---	---	---					
SMARCC2	6601	broad.mit.edu	37	12	56558379	56558381	+	In_Frame_Del	DEL	AGG	AGG	-			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr12:56558379_56558381delAGG	ENST00000550164.1	-	28	3381_3383	c.3367_3369delCCT	c.(3367-3369)del	p.P1123del	SMARCC2_ENST00000347471.4_Intron|SMARCC2_ENST00000267064.4_In_Frame_Del_p.P1092del|SMARCC2_ENST00000394023.3_Intron|RP11-977G19.5_ENST00000553176.1_RNA			Q8TAQ2	SMRC2_HUMAN	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2	1092	Pro-rich.			HGHHHHLPFA -> MGSPPSPVR (in Ref. 1; AAC50694).	chromatin remodeling|negative regulation of transcription, DNA-dependent|nervous system development|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nBAF complex|npBAF complex|nucleoplasm|SWI/SNF complex	DNA binding|protein binding|transcription coactivator activity			breast(1)|central_nervous_system(3)|endometrium(6)|kidney(3)|large_intestine(3)|lung(20)|ovary(1)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)	41			OV - Ovarian serous cystadenocarcinoma(18;0.123)			TGGATGGAGCAGGAGGAGGAGGA	0.591													7	216	---	---	---	---					
SNRNP35	11066	broad.mit.edu	37	12	123950763	123950764	+	Frame_Shift_Del	DEL	GA	GA	-			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr12:123950763_123950764delGA	ENST00000526639.2	+	2	1255_1256	c.676_677delGA	c.(676-678)gfs	p.E226fs	SNRNP35_ENST00000527158.2_Intron|SNRNP35_ENST00000412157.2_Frame_Shift_Del_p.E231fs|SNRNP35_ENST00000350887.5_Frame_Shift_Del_p.E226fs	NM_022717.2	NP_073208.1	Q16560	U1SBP_HUMAN	small nuclear ribonucleoprotein 35kDa (U11/U12)	226	Arg-rich.				mRNA processing	U12-type spliceosomal complex	nucleotide binding|RNA binding	p.E226*(1)		NS(1)|large_intestine(1)|lung(4)|prostate(1)|skin(1)	8						CAATGACTGGGAGAGAGAGAGG	0.554													7	344	---	---	---	---					
MIR4500HG	0	broad.mit.edu	37	13	88157968	88157969	+	RNA	DEL	AG	AG	-			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr13:88157968_88157969delAG	ENST00000436290.2	-	0	233					NR_033829.1																						acagagaggcagagagagagag	0.450													2	4	---	---	---	---					
COCH	1690	broad.mit.edu	37	14	31355263	31355270	+	Frame_Shift_Del	DEL	GCTGTACA	GCTGTACA	-			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr14:31355263_31355270delGCTGTACA	ENST00000460581.2	+	9	1432_1439	c.886_893delGCTGTACA	c.(886-894)gfs	p.AVQ296fs	RP11-829H16.3_ENST00000555108.1_RNA|COCH_ENST00000396618.3_Frame_Shift_Del_p.AVQ408fs|COCH_ENST00000382493.4_Frame_Shift_Del_p.AVQ259fs|COCH_ENST00000475087.1_Frame_Shift_Del_p.AVQ408fs|COCH_ENST00000216361.4_Frame_Shift_Del_p.AVQ408fs			O43405	COCH_HUMAN	cochlin	408	VWFA 1.				sensory perception of sound	proteinaceous extracellular matrix				central_nervous_system(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)|lung(7)|pancreas(1)|skin(3)	19	Hepatocellular(127;0.0877)|Breast(36;0.148)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.0119)|BRCA - Breast invasive adenocarcinoma(188;0.0805)	GBM - Glioblastoma multiforme(265;0.00645)		CAAGATAGCTGCTGTACAGTTTACTTAT	0.442													38	417	---	---	---	---					
FOXN3	1112	broad.mit.edu	37	14	89629149	89629151	+	In_Frame_Del	DEL	GAG	GAG	-	rs139532153		TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr14:89629149_89629151delGAG	ENST00000345097.4	-	7	1196_1198	c.1080_1082delCTC	c.(1078-1083)tca>tc	p.SS360del	FOXN3_ENST00000557258.1_In_Frame_Del_p.SS338del|FOXN3_ENST00000261302.5_In_Frame_Del_p.SS360del|FOXN3_ENST00000555353.1_In_Frame_Del_p.SS338del	NM_001085471.1	NP_001078940.1	O00409	FOXN3_HUMAN	forkhead box N3	360					DNA damage checkpoint|embryo development|G2 phase of mitotic cell cycle|negative regulation of transcription, DNA-dependent|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|promoter binding|protein C-terminus binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding			endometrium(4)|large_intestine(4)|lung(5)|ovary(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	18						GTCGTCGGCTGAGGAGGAGGAGG	0.650													8	274	---	---	---	---					
CHGA	1113	broad.mit.edu	37	14	93397924	93397926	+	In_Frame_Del	DEL	GAG	GAG	-			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr14:93397924_93397926delGAG	ENST00000216492.5	+	6	965_967	c.685_687delGAG	c.(685-687)del	p.E236del	CHGA_ENST00000334654.4_Intron|CHGA_ENST00000553866.1_3'UTR	NM_001275.3	NP_001266.1	P10645	CMGA_HUMAN	chromogranin A (parathyroid secretory protein 1)	236					regulation of blood pressure	extracellular region|stored secretory granule				cervix(1)|large_intestine(1)|lung(3)|skin(3)	8		all_cancers(154;0.0843)		Epithelial(152;0.102)|COAD - Colon adenocarcinoma(157;0.208)|all cancers(159;0.224)		AAAGAGAgaagaggaggaggagg	0.645													7	219	---	---	---	---					
DDX24	57062	broad.mit.edu	37	14	94545821	94545823	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr14:94545821_94545823delCCT	ENST00000330836.5	-	2	397_399	c.266_268delAGG	c.(265-270)gga>g	p.EG89del	DDX24_ENST00000544005.1_Intron|DDX24_ENST00000555054.1_In_Frame_Del_p.EG46del	NM_020414.3	NP_065147.1	Q9GZR7	DDX24_HUMAN	DEAD (Asp-Glu-Ala-Asp) box helicase 24	89	Poly-Glu.				RNA metabolic process	cytoplasm|nucleolus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			cervix(3)|endometrium(4)|kidney(4)|large_intestine(5)|lung(3)|ovary(2)|skin(1)|urinary_tract(1)	23		all_cancers(154;0.12)		Epithelial(152;0.114)|all cancers(159;0.19)|COAD - Colon adenocarcinoma(157;0.207)		CTAGACTTTCCCTCCTCCTCCTC	0.443													9	818	---	---	---	---					
GOLGA8DP	0	broad.mit.edu	37	15	22709778	22709779	+	RNA	DEL	TC	TC	-			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr15:22709778_22709779delTC	ENST00000314246.8	-	0	1069																											CATGCTACCATCTCTCTCTCTG	0.535													8	1237	---	---	---	---					
HERC2P2	0	broad.mit.edu	37	15	23312380	23312380	+	RNA	DEL	T	T	-			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr15:23312380delT	ENST00000560464.1	-	0	3118																											TGTTAttttcttttttttttt	0.398													8	53	---	---	---	---					
RP11-23E10.4	0	broad.mit.edu	37	16	33365793	33365793	+	RNA	DEL	T	T	-			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr16:33365793delT	ENST00000568520.1	-	0	84																											TTTCTCTCCCTTATGGCTTCT	0.368													3	4	---	---	---	---					
RP11-51O6.1	0	broad.mit.edu	37	16	61089598	61089599	+	RNA	INS	-	-	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr16:61089598_61089599insC	ENST00000591758.1	-	0	269_270																											TAGCACCACCAGAAGTCTCAAC	0.426													7	333	---	---	---	---					
NPIPB15	440348	broad.mit.edu	37	16	74425400	74425402	+	In_Frame_Del	DEL	CAA	CAA	-			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr16:74425400_74425402delCAA	ENST00000429990.1	+	7	850_852	c.754_756delCAA	c.(754-756)del	p.Q253del						nuclear pore complex interacting protein family, member B15																		TCCTCCAACTCAACAACATTCTA	0.517													11	473	---	---	---	---					
RP1-37N7.4	0	broad.mit.edu	37	17	18345812	18345812	+	RNA	DEL	G	G	-			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr17:18345812delG	ENST00000580052.1	+	0	43																											AGGCTCCTGAGGCTCCCCGGC	0.617													5	8	---	---	---	---					
RNF135	84282	broad.mit.edu	37	17	29325974	29325984	+	Frame_Shift_Del	DEL	GCCAGCTCTCT	GCCAGCTCTCT	-			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr17:29325974_29325984delGCCAGCTCTCT	ENST00000328381.5	+	5	1937_1947	c.1064_1074delGCCAGCTCTCT	c.(1063-1074)afs	p.SQLS355fs	RNF135_ENST00000324689.4_3'UTR|RNF135_ENST00000535306.2_3'UTR|RNF135_ENST00000443677.2_3'UTR	NM_032322.3	NP_115698.3	Q8IUD6	RN135_HUMAN	ring finger protein 135	355	B30.2/SPRY.				innate immune response|negative regulation of type I interferon production|positive regulation of interferon-beta production|regulation of innate immune response	cytosol	protein binding|ribonucleoprotein binding|ubiquitin-protein ligase activity|zinc ion binding	p.?(1)		breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(1)|skin(2)|urinary_tract(1)	10		all_cancers(10;8.65e-08)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Myeloproliferative disorder(56;0.0255)				AAGGGGACTAGCCAGCTCTCTGCATGGCACA	0.573													35	308	---	---	---	---					
WIPF2	147179	broad.mit.edu	37	17	38421174	38421176	+	In_Frame_Del	DEL	CTC	CTC	-	rs151273872	byFrequency	TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr17:38421174_38421176delCTC	ENST00000323571.4	+	5	986_988	c.746_748delCTC	c.(745-750)gct>g	p.AP249del	WIPF2_ENST00000394103.3_Intron|WIPF2_ENST00000583130.1_In_Frame_Del_p.AP249del|WIPF2_ENST00000585043.1_In_Frame_Del_p.AP249del|WIPF2_ENST00000536600.1_Intron|WIPF2_ENST00000494757.1_3'UTR	NM_133264.4	NP_573571.1	Q8TF74	WIPF2_HUMAN	WAS/WASL interacting protein family, member 2	249						cytoplasm|cytoskeleton	actin binding			NS(1)|breast(1)|endometrium(2)|kidney(2)|large_intestine(4)|lung(6)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(5)	30						CAGTCTCTGGCTCCTCCTCCTCC	0.596										HNSCC(43;0.11)			7	1163	---	---	---	---					
SEH1L	81929	broad.mit.edu	37	18	12986927	12986929	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr18:12986927_12986929delTCC	ENST00000399892.2	+	9	1238_1240	c.1137_1139delTCC	c.(1135-1140)ctt>ct	p.LP379del	SEH1L_ENST00000262124.11_3'UTR|RP11-773H22.4_ENST00000588211.1_RNA	NM_001013437.1	NP_001013455.1	Q96EE3	SEH1_HUMAN	SEH1-like (S. cerevisiae)	0					attachment of spindle microtubules to kinetochore involved in mitotic sister chromatid segregation|carbohydrate metabolic process|cell division|glucose transport|mitotic metaphase plate congression|mitotic prometaphase|mRNA transport|nuclear pore organization|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex				central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(5)|pancreas(1)|prostate(1)	11						CCCAGCTCCTtcctcctcctcct	0.522													7	284	---	---	---	---					
ZNF812	729648	broad.mit.edu	37	19	9801486	9801489	+	Frame_Shift_Del	DEL	AGTG	AGTG	-			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr19:9801486_9801489delAGTG	ENST00000457674.2	-	5	1208_1211	c.690_693delCACT	c.(688-693)ttfs	p.FT230fs	ZNF812_ENST00000536819.1_5'UTR	NM_001199814.1	NP_001186743.1	P0C7V5	ZN812_HUMAN	zinc finger protein 812	230					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						GAGAAAAATTAGTGAAGGATTTCC	0.353													19	186	---	---	---	---					
SPRED3	399473	broad.mit.edu	37	19	38882864	38882866	+	In_Frame_Del	DEL	CCT	CCT	-			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr19:38882864_38882866delCCT	ENST00000587013.1	+	3	569_571	c.491_493delCCT	c.(490-495)ccc>c	p.PS164del	SPRED3_ENST00000587564.2_3'UTR|SPRED3_ENST00000338502.4_In_Frame_Del_p.PS120del|SPRED3_ENST00000586301.1_In_Frame_Del_p.PS120del			Q2MJR0	SPRE3_HUMAN	sprouty-related, EVH1 domain containing 3	120					multicellular organismal development					central_nervous_system(2)|large_intestine(1)|lung(5)|skin(1)	9	all_cancers(60;3.4e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)			TCACTCAccccctcctcctcctc	0.645													9	128	---	---	---	---					
SLC8A2	6543	broad.mit.edu	37	19	47935681	47935683	+	In_Frame_Del	DEL	TCC	TCC	-			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr19:47935681_47935683delTCC	ENST00000236877.6	-	9	2525_2527	c.2130_2132delGGA	c.(2128-2133)gac>ga	p.ED710del	SLC8A2_ENST00000539381.1_In_Frame_Del_p.ED173del|SLC8A2_ENST00000601757.1_5'UTR|SLC8A2_ENST00000542837.1_In_Frame_Del_p.ED466del	NM_015063.2	NP_055878.1	Q9UPR5	NAC2_HUMAN	solute carrier family 8 (sodium/calcium exchanger), member 2	710					cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			breast(1)|endometrium(4)|kidney(2)|large_intestine(4)|lung(10)|ovary(2)|prostate(2)|skin(5)|stomach(1)	31		all_cancers(25;3.05e-07)|all_lung(116;4.19e-06)|Lung NSC(112;7.16e-06)|all_epithelial(76;7.65e-06)|all_neural(266;0.0652)|Ovarian(192;0.086)|Breast(70;0.173)		OV - Ovarian serous cystadenocarcinoma(262;0.000501)|all cancers(93;0.00058)|Epithelial(262;0.0181)|GBM - Glioblastoma multiforme(486;0.0457)		CCGGGACCCGTCCTCCTCCTCCT	0.616													21	759	---	---	---	---					
EPS8L1	54869	broad.mit.edu	37	19	55597500	55597501	+	Frame_Shift_Ins	INS	-	-	A			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr19:55597500_55597501insA	ENST00000201647.6	+	16	1646_1647	c.1590_1591insA	c.(1588-1593)aatcctfs	p.NP530fs	EPS8L1_ENST00000245618.5_Frame_Shift_Ins_p.NP403fs|EPS8L1_ENST00000588359.1_Frame_Shift_Ins_p.NP216fs|EPS8L1_ENST00000586329.1_Intron|EPS8L1_ENST00000540810.1_Frame_Shift_Ins_p.NP466fs	NM_133180.2	NP_573441.2	Q8TE68	ES8L1_HUMAN	EPS8-like 1	530	SH3.					cytoplasm				NS(1)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|liver(2)|lung(3)|ovary(1)|prostate(1)	12			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.044)		TGCCCTACAACATCCTGACACC	0.629													22	492	---	---	---	---					
DNAAF3	352909	broad.mit.edu	37	19	55670960	55670961	+	In_Frame_Ins	INS	-	-	AGA			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr19:55670960_55670961insAGA	ENST00000527223.2	-	11	1380_1381	c.1379_1380insTCT	c.(1378-1380)cat>cTCTat	p.460_460H>LY	CTD-2587H24.4_ENST00000587871.1_In_Frame_Ins_p.54_55SS>SLS|DNAAF3_ENST00000524407.2_In_Frame_Ins_p.393_393H>LY|CTD-2587H24.5_ENST00000591665.1_RNA|DNAAF3_ENST00000391720.4_In_Frame_Ins_p.440_440H>LY|DNAAF3_ENST00000587789.2_5'UTR|DNAAF3_ENST00000455045.1_In_Frame_Ins_p.339_339H>LY	NM_001256714.1	NP_001243643.1	Q8N9W5	CS051_HUMAN	dynein, axonemal, assembly factor 3	393																	GCTCAGGGATGAGAAGATGGAC	0.599													9	813	---	---	---	---					
DGCR5	0	broad.mit.edu	37	22	19001654	19001655	+	RNA	DEL	AA	AA	-	rs79891328		TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr22:19001654_19001655delAA	ENST00000440005.2	+	0	684				DGCR5_ENST00000424407.1_RNA																							actctatatcaaaaaaaaaaaa	0.446													2	4	---	---	---	---					
SF3A1	10291	broad.mit.edu	37	22	30742328	30742330	+	In_Frame_Del	DEL	CTG	CTG	-	rs141985009	byFrequency	TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chr22:30742328_30742330delCTG	ENST00000215793.7	-	3	518_520	c.364_366delCAG	c.(364-366)del	p.Q122del	SF3A1_ENST00000439242.1_Intron	NM_005877.4	NP_005868.1	Q15459	SF3A1_HUMAN	splicing factor 3a, subunit 1, 120kDa	122	Poly-Gln.				nuclear mRNA 3'-splice site recognition	catalytic step 2 spliceosome|nucleoplasm|U2-type spliceosomal complex	protein binding|RNA binding			endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(9)|ovary(4)|pancreas(1)|prostate(1)|urinary_tract(1)	29						GCTGGGTGGTCTGCTGCTGCTGC	0.606													8	677	---	---	---	---					
TRPC5	7224	broad.mit.edu	37	X	111090417	111090418	+	Frame_Shift_Ins	INS	-	-	C			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrX:111090417_111090418insC	ENST00000262839.2	-	6	2542_2543	c.1624_1625insG	c.(1624-1626)tgafs	p.*542fs		NM_012471.2	NP_036603.1	Q9UL62	TRPC5_HUMAN	transient receptor potential cation channel, subfamily C, member 5	542					axon guidance	calcium channel complex|integral to plasma membrane	protein binding|store-operated calcium channel activity			biliary_tract(1)|breast(4)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(6)|lung(38)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	62						TCTGGTTTCATAATAGAAGTAA	0.441													7	486	---	---	---	---					
PASD1	139135	broad.mit.edu	37	X	150817142	150817144	+	In_Frame_Del	DEL	GCT	GCT	-			TCGA-HZ-7918-01A-11D-2154-08	TCGA-HZ-7918-10A-01D-2154-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37fb4f51-7109-4ef2-9ef5-9524ff4162dd	c38bb93b-3f01-430e-8066-dad94b77cb5a	g.chrX:150817142_150817144delGCT	ENST00000370357.4	+	9	930_932	c.685_687delGCT	c.(685-687)del	p.A236del		NM_173493.2	NP_775764.2	Q8IV76	PASD1_HUMAN	PAS domain containing 1	236	Poly-Ala.					nucleus	signal transducer activity	p.A229A(2)		breast(2)|cervix(1)|endometrium(5)|kidney(2)|large_intestine(3)|liver(1)|lung(25)|ovary(3)|pancreas(1)|prostate(1)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	48	Acute lymphoblastic leukemia(192;6.56e-05)					CGTTGAACCCgctgctgctgctg	0.433													8	518	---	---	---	---					
