Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut	init_n_lod
KCNA10	3744	broad.mit.edu	37	1	111061291	111061291	+	Missense_Mutation	SNP	C	T	T	rs139383016		TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr1:111061291C>T	uc001dzt.1	-	1	507	c.119G>A	c.(118-120)CGG>CAG	p.R40Q		NM_005549	NP_005540	Q16322	KCA10_HUMAN	potassium voltage-gated channel, shaker-related	40						voltage-gated potassium channel complex	intracellular cyclic nucleotide activated cation channel activity|voltage-gated potassium channel activity			ovary(3)|large_intestine(1)	4		all_cancers(81;4.57e-06)|all_epithelial(167;1.52e-05)|all_lung(203;0.000152)|Lung NSC(277;0.000301)		Lung(183;0.0238)|all cancers(265;0.0874)|Colorectal(144;0.103)|Epithelial(280;0.116)|LUSC - Lung squamous cell carcinoma(189;0.134)		GCCCCCAGGCCGGCCTTTTGG	0.532000													19	91					0	0	0.008871	0	0	
SYT6	148281	broad.mit.edu	37	1	114682265	114682265	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr1:114682265G>A	uc001eev.2	-	2	479	c.229C>T	c.(229-231)CAA>TAA	p.Q77*		NM_205848	NP_995320	Q5T7P8	SYT6_HUMAN	synaptotagmin VI	162	Cytoplasmic (Potential).				acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		TCTGTAGTTTGCCGCTGCAGC	0.592000													20	54					0	0	0.014323	0	0	
UBAP2L	9898	broad.mit.edu	37	1	154223741	154223741	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr1:154223741C>T	uc001fep.3	+	13	1605	c.1438C>T	c.(1438-1440)CCG>TCG	p.P480S	UBAP2L_uc009wot.2_Missense_Mutation_p.P480S|UBAP2L_uc010pek.1_Missense_Mutation_p.P472S|UBAP2L_uc010pel.1_Missense_Mutation_p.P490S|UBAP2L_uc010pen.1_Missense_Mutation_p.P394S	NM_014847	NP_055662	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like isoform a	480					binding of sperm to zona pellucida		protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			TAGCCCTCAGCCGGCTCAGCA	0.502000													4	171					0	0	0.009096	0	0	
RGS7	6000	broad.mit.edu	37	1	240966205	240966205	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr1:240966205T>G	uc001hyv.2	-	16	1688	c.1358A>C	c.(1357-1359)AAG>ACG	p.K453T	RGS7_uc010pyh.1_Missense_Mutation_p.K427T|RGS7_uc010pyj.1_Missense_Mutation_p.K369T|RGS7_uc001hyu.2_Missense_Mutation_p.K453T|RGS7_uc009xgn.1_Missense_Mutation_p.K400T|RGS7_uc001hyw.2_Missense_Mutation_p.K453T|RGS7_uc001hyt.2_Missense_Mutation_p.K285T	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	453					G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			AACCAGTACCTTTTTCTTTGC	0.363000													9	216					0	0	0.010729	0	0	
SPAG6	9576	broad.mit.edu	37	10	22657513	22657513	+	Silent	SNP	A	C	C			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr10:22657513A>C	uc001iri.2	+	4	520	c.378A>C	c.(376-378)GCA>GCC	p.A126A	SPAG6_uc001irj.2_Silent_p.A126A|SPAG6_uc010qct.1_Silent_p.A96A|SPAG6_uc009xkh.2_Silent_p.A104A	NM_012443	NP_036575	O75602	SPAG6_HUMAN	sperm associated antigen 6 isoform 1	126	ARM 3.				cell projection organization|spermatid development	axoneme|cilium|cytoplasm|flagellum|microtubule	binding			breast(1)	1						ATTGTGGAGCACTGGATACGC	0.478000													38	129					0	0	0.005524	0	0	
COX15	1355	broad.mit.edu	37	10	101483725	101483725	+	Silent	SNP	G	A	A			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr10:101483725G>A	uc001kqb.3	-	5	1355	c.738C>T	c.(736-738)CTC>CTT	p.L246L	COX15_uc001kqc.3_Silent_p.L246L|COX15_uc010qpj.1_Silent_p.L67L	NM_078470	NP_510870	Q7KZN9	COX15_HUMAN	COX15 homolog isoform 1	246	Helical; (Potential).				heme a biosynthetic process|respiratory chain complex IV assembly|respiratory gaseous exchange	integral to membrane|mitochondrial respiratory chain	cytochrome-c oxidase activity			ovary(1)	1		Colorectal(252;0.234)		Epithelial(162;3.08e-10)|all cancers(201;2.43e-08)		TGTGCGGAGGGAGTAGCAGTG	0.338000													46	150					0	0	0.014410	0	0	
HSPA12A	259217	broad.mit.edu	37	10	118434813	118434813	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr10:118434813G>A	uc001lct.2	-	12	1612	c.1507C>T	c.(1507-1509)CGG>TGG	p.R503W	HSPA12A_uc001lcu.2_Missense_Mutation_p.R420W	NM_025015	NP_079291	O43301	HS12A_HUMAN	heat shock 70kDa protein 12A	503							ATP binding			ovary(1)	1				all cancers(201;0.0158)		ATGATGATCCGGCACTGGTCC	0.672000													15	45					0	0	0.008871	0	0	
TUBGCP2	10844	broad.mit.edu	37	10	135096623	135096623	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr10:135096623T>C	uc001lmg.1	-	15	2605	c.2248A>G	c.(2248-2250)AAG>GAG	p.K750E	TUBGCP2_uc001lmf.1_Missense_Mutation_p.K343E|TUBGCP2_uc010qvc.1_Missense_Mutation_p.K778E|TUBGCP2_uc009ybk.1_Missense_Mutation_p.K773E|TUBGCP2_uc010qvd.1_Missense_Mutation_p.K620E|TUBGCP2_uc001lmh.1_RNA	NM_006659	NP_006650	Q9BSJ2	GCP2_HUMAN	tubulin, gamma complex associated protein 2	750					G2/M transition of mitotic cell cycle|microtubule nucleation|protein complex assembly	centrosome|cytoplasmic microtubule|cytosol|spindle pole	protein binding				0		all_cancers(35;1.14e-09)|all_epithelial(44;5.79e-08)|Lung NSC(174;0.00263)|all_lung(145;0.0039)|all_neural(114;0.0299)|Melanoma(40;0.123)|Colorectal(31;0.172)|Glioma(114;0.203)		OV - Ovarian serous cystadenocarcinoma(35;8.87e-06)|all cancers(32;8.98e-06)|Epithelial(32;1.15e-05)		GACATGAGCTTGGAGAAGACC	0.607000													3	159					0	0	0.004672	0	0	
OR4C16	219428	broad.mit.edu	37	11	55339628	55339628	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr11:55339628G>A	uc010rih.1	+	1	25	c.25G>A	c.(25-27)GAG>AAG	p.E9K		NM_001004701	NP_001004701	Q8NGL9	OR4CG_HUMAN	olfactory receptor, family 4, subfamily C,	9	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		all_epithelial(135;0.0748)				TAATGTGACTGAGTTCATTCT	0.373000													45	150					0	0	0.014410	0	0	
RASGRP2	10235	broad.mit.edu	37	11	64510268	64510268	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr11:64510268A>G	uc009ypu.2	-	2	298	c.71T>C	c.(70-72)TTC>TCC	p.F24S	RASGRP2_uc001oat.2_5'Flank|RASGRP2_uc001oau.2_5'Flank|RASGRP2_uc009ypv.2_Missense_Mutation_p.F24S|RASGRP2_uc009ypw.2_Missense_Mutation_p.F24S|RASGRP2_uc001oaw.1_Missense_Mutation_p.S327P	NM_001098671	NP_001092141	Q7LDG7	GRP2_HUMAN	RAS guanyl releasing protein 2	24	N-terminal Ras-GEF.				platelet activation|Ras protein signal transduction|regulation of cell growth|regulation of small GTPase mediated signal transduction	cell junction|cytosol|ruffle membrane|synapse|synaptosome	calcium ion binding|diacylglycerol binding|guanyl-nucleotide exchange factor activity				0						CCACTCACCGAAGGCTTCGAT	0.726000													3	14					0	0	0.001984	0	0	
PAK1	5058	broad.mit.edu	37	11	77070042	77070042	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr11:77070042C>G	uc001oyh.3	-	6	1031	c.498G>C	c.(496-498)GAG>GAC	p.E166D	PAK1_uc010rso.1_Missense_Mutation_p.E68D|PAK1_uc001oyg.3_Missense_Mutation_p.E166D|PAK1_uc001oyi.1_Missense_Mutation_p.E166D|PAK1_uc010rsn.1_5'UTR	NM_002576	NP_002567	Q13153	PAK1_HUMAN	p21-activated kinase 1 isoform 2	166	Interaction with CRIPAK.				apoptosis|axon guidance|cytoskeleton organization|ER-nucleus signaling pathway|positive regulation of JUN kinase activity|positive regulation of peptidyl-serine phosphorylation|protein autophosphorylation|T cell costimulation|T cell receptor signaling pathway	cytosol|focal adhesion|Golgi apparatus	ATP binding|collagen binding|protein binding|protein serine/threonine kinase activity			skin(2)|stomach(1)|lung(1)	4	all_cancers(14;1.75e-18)					CTGCAGGAGTCTCAGACACAG	0.443000													27	89					0	0	0.004656	0	0	
FOLH1B	219595	broad.mit.edu	37	11	89403629	89403629	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr11:89403629G>A	uc001pda.2	+	4	693	c.167G>A	c.(166-168)GGA>GAA	p.G56E		NM_153696	NP_710163	Q9HBA9	FOH1B_HUMAN	folate hydrolase 1B	56					proteolysis	cytoplasm	dipeptidase activity|metal ion binding|metallopeptidase activity			ovary(3)|skin(2)|central_nervous_system(1)	6						ACTCTCAGAGGAGCAGTGGAA	0.239000													14	177					0	0	0.004007	0	0	
TMCC3	57458	broad.mit.edu	37	12	94976263	94976263	+	Missense_Mutation	SNP	C	T	T	rs151064246		TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr12:94976263C>T	uc001tdj.2	-	2	248	c.130G>A	c.(130-132)GGG>AGG	p.G44R	TMCC3_uc001tdi.2_Missense_Mutation_p.G13R	NM_020698	NP_065749	Q9ULS5	TMCC3_HUMAN	transmembrane and coiled-coil domain family 3	44						integral to membrane				ovary(1)|skin(1)	2						TCTGACCCCCCTCGGCGTATG	0.453000													56	195					0	0	0.014410	0	0	
GPR133	283383	broad.mit.edu	37	12	131569149	131569149	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr12:131569149G>A	uc001uit.3	+	15	2171	c.1612G>A	c.(1612-1614)GTC>ATC	p.V538I	GPR133_uc010tbm.1_Missense_Mutation_p.V570I|GPR133_uc009zyo.2_5'UTR|GPR133_uc001uiv.1_Missense_Mutation_p.V57I	NM_198827	NP_942122	Q6QNK2	GP133_HUMAN	G protein-coupled receptor 133 precursor	538	GPS.|Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			pancreas(5)|ovary(3)|skin(2)	10	all_neural(191;0.0982)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.68e-06)|all cancers(50;2.71e-06)|Epithelial(86;6.75e-06)		CACCTACTCCGTCTGCCGCTG	0.622000													32	35					0	0	0.006999	0	0	
EP400	57634	broad.mit.edu	37	12	132551418	132551418	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr12:132551418G>A	uc001ujn.2	+	48	8688	c.8653G>A	c.(8653-8655)GTC>ATC	p.V2885I	EP400_uc001ujl.2_Missense_Mutation_p.V2884I|EP400_uc001ujm.2_Missense_Mutation_p.V2804I|EP400_uc001ujp.2_Missense_Mutation_p.V95I	NM_015409	NP_056224	Q96L91	EP400_HUMAN	E1A binding protein p400	2921					histone H2A acetylation|histone H4 acetylation|regulation of transcription, DNA-dependent	NuA4 histone acetyltransferase complex|nuclear speck	ATP binding|DNA binding|helicase activity	p.P2885P(1)		central_nervous_system(4)|ovary(3)|breast(3)|skin(2)	12	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.198)		OV - Ovarian serous cystadenocarcinoma(86;3.01e-08)|Epithelial(86;3.43e-07)|all cancers(50;2.01e-06)		GGTGGTGTCCGTCCCGGCAGC	0.682000													4	96					0	0	0.009096	0	0	
FAM124A	220108	broad.mit.edu	37	13	51854758	51854758	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr13:51854758C>T	uc001vfg.1	+	4	1138	c.1007C>T	c.(1006-1008)CCT>CTT	p.P336L	FAM124A_uc001vff.1_Missense_Mutation_p.P372L	NM_145019	NP_659456	Q86V42	F124A_HUMAN	hypothetical protein LOC220108	336										central_nervous_system(1)	1		Acute lymphoblastic leukemia(7;0.000334)|Breast(56;0.00156)|Prostate(109;0.00538)|Lung NSC(96;0.0216)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;4.25e-07)		ACAGGCCTGCCTCCTGGGCAC	0.617000													3	67					0	0	0.004672	0	0	
CCNK	8812	broad.mit.edu	37	14	99976540	99976540	+	Silent	SNP	G	C	C			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr14:99976540G>C	uc001ygi.3	+	11	1294	c.1164G>C	c.(1162-1164)CCG>CCC	p.P388P	CCNK_uc001ygg.3_Intron	NM_001099402	NP_001092872	O75909	CCNK_HUMAN	cyclin K isoform 1	388					cell division|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter		protein kinase binding				0		all_cancers(154;0.224)|all_epithelial(191;0.0643)|Melanoma(154;0.0866)				CTGAGCCGCCGGGCCCTGTGG	0.692000													2	6					0	0	0.004672	0	0	
OR4N4	283694	broad.mit.edu	37	15	22383082	22383082	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr15:22383082G>C	uc001yuc.1	+	7	1591	c.610G>C	c.(610-612)GGC>CGC	p.G204R	LOC727924_uc001yub.1_Intron|OR4N4_uc010tzv.1_Missense_Mutation_p.G204R	NM_001005241	NP_001005241	Q8N0Y3	OR4N4_HUMAN	olfactory receptor, family 4, subfamily N,	204	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_cancers(20;1.94e-20)|all_epithelial(15;3.94e-18)|Lung NSC(15;8.53e-15)|all_lung(15;2.87e-14)|Breast(32;0.00519)|Colorectal(260;0.101)	GBM - Glioblastoma multiforme(6;0.124)	all cancers(64;1.64e-11)|Epithelial(43;5.81e-10)|BRCA - Breast invasive adenocarcinoma(123;0.000255)|Kidney(6;0.00736)|KIRC - Kidney renal clear cell carcinoma(6;0.0135)|GBM - Glioblastoma multiforme(186;0.0963)		CTTCAACAGTGGCCTGATGAC	0.522000													41	441					0	0	0.014410	0	0	
AP3B2	8120	broad.mit.edu	37	15	83349607	83349607	+	Silent	SNP	G	A	A			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr15:83349607G>A	uc010uoh.1	-	7	930	c.753C>T	c.(751-753)TTC>TTT	p.F251F	AP3B2_uc010uoi.1_Silent_p.F251F|AP3B2_uc010uoj.1_Silent_p.F219F|AP3B2_uc010uog.1_5'Flank	NM_004644	NP_004635	Q13367	AP3B2_HUMAN	adaptor-related protein complex 3, beta 2	251					endocytosis|intracellular protein transport|post-Golgi vesicle-mediated transport	clathrin coated vesicle membrane|COPI-coated vesicle|membrane coat	binding|protein transporter activity			ovary(3)|breast(1)|pancreas(1)	5			BRCA - Breast invasive adenocarcinoma(143;0.229)			TGGGGCTCAGGAACTGCGTGC	0.647000													12	37					0	0	0.013537	0	0	
AKAP13	11214	broad.mit.edu	37	15	86077059	86077059	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr15:86077059C>G	uc002blv.1	+	4	596	c.426C>G	c.(424-426)CAC>CAG	p.H142Q	AKAP13_uc002bls.2_Missense_Mutation_p.H142Q|AKAP13_uc002blt.1_Missense_Mutation_p.H142Q|AKAP13_uc002blu.1_Missense_Mutation_p.H142Q	NM_007200	NP_009131	Q12802	AKP13_HUMAN	A-kinase anchor protein 13 isoform 2	142					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane|membrane fraction|nucleus	cAMP-dependent protein kinase activity|metal ion binding|protein binding|Rho guanyl-nucleotide exchange factor activity|signal transducer activity			central_nervous_system(3)|kidney(2)|urinary_tract(1)|liver(1)|skin(1)|ovary(1)	9						CATTCAGGCACCTGAAGCTGC	0.448000													22	115					0	0	0.012319	0	0	
SPSB3	90864	broad.mit.edu	37	16	1831391	1831391	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr16:1831391A>G	uc002cmr.2	-	1	127	c.94T>C	c.(94-96)TCC>CCC	p.S32P	NUBP2_uc002cmw.3_5'Flank|NUBP2_uc002cmx.3_5'Flank|NUBP2_uc010brx.2_5'Flank|SPSB3_uc002cms.2_5'UTR|SPSB3_uc002cmt.2_5'UTR|SPSB3_uc002cmu.2_Missense_Mutation_p.S32P|SPSB3_uc002cmv.2_5'UTR|SPSB3_uc010uvm.1_Missense_Mutation_p.S32P	NM_080861	NP_543137	Q6PJ21	SPSB3_HUMAN	splA/ryanodine receptor domain and SOCS box	32					intracellular signal transduction						0						CAGTTAGTGGAGCCTGCTAGA	0.672000													25	76					0	0	0.006320	0	0	
KIAA0100	9703	broad.mit.edu	37	17	26965392	26965392	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr17:26965392C>T	uc002hbu.2	-	13	1489	c.1390G>A	c.(1390-1392)GTC>ATC	p.V464I		NM_014680	NP_055495	Q14667	K0100_HUMAN	hypothetical protein LOC9703 precursor	464						extracellular region				ovary(2)|breast(1)|skin(1)	4	Lung NSC(42;0.00431)					ACAGTTAGGACGCCCCGCTGA	0.567000													8	114					0	0	0.003080	0	0	
TOP2A	7153	broad.mit.edu	37	17	38560458	38560458	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr17:38560458C>A	uc002huq.2	-	19	2355	c.2229G>T	c.(2227-2229)AAG>AAT	p.K743N		NM_001067	NP_001058	P11388	TOP2A_HUMAN	DNA topoisomerase II, alpha isozyme	743					apoptotic chromosome condensation|DNA ligation|DNA repair|DNA topological change|DNA-dependent DNA replication|mitotic cell cycle G2/M transition decatenation checkpoint|mitotic recombination|phosphatidylinositol-mediated signaling|positive regulation of apoptosis|positive regulation of retroviral genome replication|resolution of meiotic recombination intermediates|sister chromatid segregation	cytoplasm|DNA topoisomerase complex (ATP-hydrolyzing)|nucleolus|nucleoplasm|synaptonemal complex	ATP binding|chromatin binding|DNA topoisomerase (ATP-hydrolyzing) activity|DNA-dependent ATPase activity|drug binding|histone deacetylase binding|protein C-terminus binding|protein heterodimerization activity|protein homodimerization activity|protein kinase C binding|sequence-specific DNA binding transcription factor activity|ubiquitin binding			ovary(4)|large_intestine(1)|central_nervous_system(1)|skin(1)	7		Breast(137;0.00328)	STAD - Stomach adenocarcinoma(5;0.00183)		Amsacrine(DB00276)|Ciprofloxacin(DB00537)|Dexrazoxane(DB00380)|Doxorubicin(DB00997)|Enoxacin(DB00467)|Epirubicin(DB00445)|Etoposide(DB00773)|Fleroxacin(DB04576)|Gatifloxacin(DB01044)|Idarubicin(DB01177)|Levofloxacin(DB01137)|Lomefloxacin(DB00978)|Lucanthone(DB04967)|Mitoxantrone(DB01204)|Moxifloxacin(DB00218)|Norfloxacin(DB01059)|Ofloxacin(DB01165)|Pefloxacin(DB00487)|Podofilox(DB01179)|Sparfloxacin(DB01208)|Teniposide(DB00444)|Trovafloxacin(DB00685)|Valrubicin(DB00385)	ATTGGGCAACCTTTACTTCTC	0.378000													108	285					1.22908e-42	1.44689e-42	0.014410	1	0	
STAT3	6774	broad.mit.edu	37	17	40498723	40498723	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr17:40498723G>A	uc002hzl.1	-	3	377	c.137C>T	c.(136-138)GCG>GTG	p.A46V	STAT3_uc002hzk.1_Missense_Mutation_p.A46V|STAT3_uc002hzm.1_Missense_Mutation_p.A46V|STAT3_uc010wgh.1_5'UTR|STAT3_uc002hzn.1_Missense_Mutation_p.A46V	NM_139276	NP_644805	P40763	STAT3_HUMAN	signal transducer and activator of transcription	46					cellular component movement|eating behavior|eye photoreceptor cell differentiation|glucose homeostasis|interleukin-6-mediated signaling pathway|interspecies interaction between organisms|JAK-STAT cascade involved in growth hormone signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein import into nucleus|response to estradiol stimulus|sexual reproduction|temperature homeostasis	cytosol|nucleus|plasma membrane	calcium ion binding|ligand-regulated transcription factor activity|protein dimerization activity|protein kinase binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)|lung(1)|breast(1)|central_nervous_system(1)	4		all_cancers(22;1.39e-06)|all_epithelial(22;2.95e-05)|Breast(137;0.000135)		BRCA - Breast invasive adenocarcinoma(366;0.139)		TTTGCTGGCCGCATATGCCCT	0.433000									Hyperimmunoglobulin_E_Recurrent_Infection_Syndrome				6	420					0	0	0.001168	0	0	
CDH2	1000	broad.mit.edu	37	18	25585844	25585844	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr18:25585844C>A	uc002kwg.2	-	6	1275	c.816G>T	c.(814-816)TGG>TGT	p.W272C	CDH2_uc010xbn.1_Missense_Mutation_p.W241C	NM_001792	NP_001783	P19022	CADH2_HUMAN	cadherin 2, type 1 preproprotein	272	Extracellular (Potential).|Cadherin 2.				adherens junction organization|cell junction assembly|positive regulation of muscle cell differentiation	catenin complex|integral to membrane	alpha-catenin binding|beta-catenin binding|calcium ion binding|gamma-catenin binding	p.W272R(1)		ovary(3)|lung(1)	4						CTGTCCCATTCCAAACCTGGT	0.388000													62	201					3.13743e-37	3.64726e-37	0.014410	1	0	
ZNF554	115196	broad.mit.edu	37	19	2834817	2834817	+	Silent	SNP	G	A	A			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr19:2834817G>A	uc002lwm.2	+	5	1782	c.1584G>A	c.(1582-1584)GCG>GCA	p.A528A	ZNF554_uc002lwl.2_Silent_p.A477A	NM_001102651	NP_001096121	Q86TJ5	ZN554_HUMAN	zinc finger protein 554	528					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GTGGGAAAGCGTTCTACCAGA	0.428000													48	140					0	0	0.014410	0	0	
RANBP3	8498	broad.mit.edu	37	19	5917945	5917945	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr19:5917945C>T	uc002mdw.2	-	16	1747	c.1520G>A	c.(1519-1521)CGC>CAC	p.R507H	RANBP3_uc002mdv.2_Missense_Mutation_p.R226H|RANBP3_uc002mdx.2_Missense_Mutation_p.R502H|RANBP3_uc002mdy.2_Missense_Mutation_p.R439H|RANBP3_uc002mdz.2_Missense_Mutation_p.R434H|RANBP3_uc010duq.2_Missense_Mutation_p.R412H|RANBP3_uc002mea.2_Missense_Mutation_p.R374H|RANBP3_uc010xix.1_Missense_Mutation_p.R379H	NM_007322	NP_015561	Q9H6Z4	RANB3_HUMAN	RAN binding protein 3 isoform RANBP3-d	507	RanBD1.				intracellular transport|protein transport	cytoplasm|nucleus	Ran GTPase binding			breast(1)	1						GGCCAGGATGCGGTGGTGCAG	0.682000													5	165					0	0	0.014758	0	0	
MAST1	22983	broad.mit.edu	37	19	12969492	12969492	+	Silent	SNP	C	T	T			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr19:12969492C>T	uc002mvm.2	+	12	1433	c.1305C>T	c.(1303-1305)GTC>GTT	p.V435V	MAST1_uc002mvk.2_Silent_p.V431V	NM_014975	NP_055790	Q9Y2H9	MAST1_HUMAN	microtubule associated serine/threonine kinase	435	Protein kinase.				cytoskeleton organization|intracellular protein kinase cascade	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|large_intestine(1)|skin(1)	7						CGTTTGTGGTCGGCATGTTCT	0.567000													5	78					0	0	0.001168	0	0	
ZNF626	199777	broad.mit.edu	37	19	20807373	20807373	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr19:20807373G>A	uc002npb.1	-	4	1460	c.1310C>T	c.(1309-1311)TCC>TTC	p.S437F	ZNF626_uc002npc.1_Missense_Mutation_p.S361F	NM_001076675	NP_001070143	Q68DY1	ZN626_HUMAN	zinc finger protein 626 isoform 1	437	C2H2-type 10.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1						AAGGATTGAGGACTGGTTGAA	0.378000													11	230					0	0	0.008291	0	0	
SLC1A5	6510	broad.mit.edu	37	19	47281994	47281994	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr19:47281994G>T	uc002pfs.2	-	5	1616	c.996C>A	c.(994-996)AAC>AAA	p.N332K	SLC1A5_uc010xyh.1_Missense_Mutation_p.N130K|SLC1A5_uc002pfq.2_Missense_Mutation_p.N156K|SLC1A5_uc002pfr.2_Missense_Mutation_p.N104K	NM_005628	NP_005619	Q15758	AAAT_HUMAN	solute carrier family 1 member 5 isoform 1	332					cellular nitrogen compound metabolic process	integral to plasma membrane|melanosome|membrane fraction	neutral amino acid transmembrane transporter activity|protein binding|receptor activity|sodium:dicarboxylate symporter activity				0		all_epithelial(76;0.00314)|Ovarian(192;0.0798)|all_neural(266;0.107)		OV - Ovarian serous cystadenocarcinoma(262;0.000338)|all cancers(93;0.000882)|Epithelial(262;0.0211)|GBM - Glioblastoma multiforme(486;0.0341)	L-Asparagine(DB00174)|L-Glutamine(DB00130)	AGCGGTAGGGGTTTTTGCGGG	0.602000													32	65					3.76114e-14	4.16411e-14	0.004289	1	0	
IRF3	3661	broad.mit.edu	37	19	50163007	50163007	+	Silent	SNP	G	A	A			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr19:50163007G>A	uc010end.1	-	8	1564	c.1182C>T	c.(1180-1182)CAC>CAT	p.H394H	IRF3_uc002pos.1_RNA|IRF3_uc002pot.1_Silent_p.H267H|IRF3_uc002pox.1_Missense_Mutation_p.H356Y|IRF3_uc002poy.1_Silent_p.H394H|IRF3_uc002pou.2_Silent_p.H394H|IRF3_uc002pov.2_Silent_p.H248H|IRF3_uc002pow.2_Missense_Mutation_p.H400Y	NM_001571	NP_001562	Q14653	IRF3_HUMAN	interferon regulatory factor 3	394					interferon-gamma-mediated signaling pathway|interspecies interaction between organisms|MyD88-independent toll-like receptor signaling pathway|negative regulation of type I interferon production|response to virus|Toll signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway|transcription from RNA polymerase II promoter|type I interferon-mediated signaling pathway	cytosol|endosome membrane|nucleoplasm|plasma membrane	DNA binding|protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription cofactor activity			ovary(2)	2		all_lung(116;3.24e-07)|Lung NSC(112;1.6e-06)|all_neural(266;0.0459)|Ovarian(192;0.0728)		OV - Ovarian serous cystadenocarcinoma(262;0.0011)|GBM - Glioblastoma multiforme(134;0.02)		TGTTGGAAATGTGCAGGTCCA	0.622000													33	98					0	0	0.005524	0	0	
CNOT3	4849	broad.mit.edu	37	19	54646728	54646728	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr19:54646728G>A	uc002qdj.1	+	2	325	c.14G>A	c.(13-15)CGC>CAC	p.R5H	CNOT3_uc010yel.1_Missense_Mutation_p.R5H|CNOT3_uc002qdi.2_5'UTR|CNOT3_uc002qdk.1_Missense_Mutation_p.R5H|CNOT3_uc010ere.1_5'Flank	NM_014516	NP_055331	O75175	CNOT3_HUMAN	CCR4-NOT transcription complex, subunit 3	5					nuclear-transcribed mRNA poly(A) tail shortening|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|nucleus	protein binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					GCGGACAAGCGCAAACTCCAA	0.527000													4	208					0	0	0.009096	0	0	
PDIA6	10130	broad.mit.edu	37	2	10930895	10930895	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr2:10930895G>C	uc002rau.2	-	7	787	c.649C>G	c.(649-651)CTG>GTG	p.L217V	PDIA6_uc010yjg.1_Missense_Mutation_p.L214V|PDIA6_uc002rav.2_Missense_Mutation_p.L269V|PDIA6_uc010yjh.1_Missense_Mutation_p.L222V|PDIA6_uc002raw.2_Missense_Mutation_p.L265V	NM_005742	NP_005733	Q15084	PDIA6_HUMAN	protein disulfide isomerase A6 precursor	217	Thioredoxin 2.				cell redox homeostasis|glycerol ether metabolic process|protein folding	endoplasmic reticulum lumen|ER-Golgi intermediate compartment|melanosome|plasma membrane	electron carrier activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.191)			Epithelial(75;0.149)|OV - Ovarian serous cystadenocarcinoma(76;0.15)		ACAGCTGCCAGTTTCACTTTT	0.413000													28	124					0	0	0.008740	0	0	
APOB	338	broad.mit.edu	37	2	21233527	21233527	+	Silent	SNP	G	A	A			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr2:21233527G>A	uc002red.2	-	26	6341	c.6213C>T	c.(6211-6213)CTC>CTT	p.L2071L		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	2071	Heparin-binding.				cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CAAAAAATGGGAGGTTAATGG	0.363000													48	144					0	0	0.013114	0	0	
APOB	338	broad.mit.edu	37	2	21241934	21241934	+	Silent	SNP	G	A	A			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr2:21241934G>A	uc002red.2	-	20	3179	c.3051C>T	c.(3049-3051)AGC>AGT	p.S1017S		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1017					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CATAGGTTGCGCTGACAGAAT	0.448000													52	186					0	0	0.014410	0	0	
LRPPRC	10128	broad.mit.edu	37	2	44139618	44139618	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr2:44139618T>G	uc002rtr.2	-	30	3286	c.3228A>C	c.(3226-3228)TTA>TTC	p.L1076F	LRPPRC_uc010yob.1_Missense_Mutation_p.L976F	NM_133259	NP_573566	P42704	LPPRC_HUMAN	leucine-rich PPR motif-containing protein	1076	PPR 16.				mitochondrion transport along microtubule|mRNA transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	condensed nuclear chromosome|cytoskeleton|mitochondrial nucleoid|nuclear inner membrane|nuclear outer membrane|nucleoplasm|perinuclear region of cytoplasm	beta-tubulin binding|microtubule binding|RNA binding			ovary(2)|skin(1)	3		all_hematologic(82;0.166)|Acute lymphoblastic leukemia(82;0.17)				CTGACATCAGTAATTTAATGA	0.323000													31	92					0	0	0.008361	0	0	
NRXN1	9378	broad.mit.edu	37	2	50765393	50765393	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr2:50765393C>G	uc010fbq.2	-	10	3738	c.2261G>C	c.(2260-2262)AGA>ACA	p.R754T	NRXN1_uc002rxb.3_Missense_Mutation_p.R386T|NRXN1_uc002rxe.3_Missense_Mutation_p.R714T|NRXN1_uc002rxc.1_RNA	NM_001135659	NP_001129131	P58400	NRX1B_HUMAN	neurexin 1 isoform alpha2 precursor	Error:Variant_position_missing_in_P58400_after_alignment					angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			AATCCTACCTCTCTCACAGGA	0.448000													44	155					0	0	0.008740	0	0	
GGT8P	645367	broad.mit.edu	37	2	91969019	91969019	+	RNA	SNP	A	G	G			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr2:91969019A>G	uc010fho.1	+	2		c.1350A>G				NR_003503				Homo sapiens cDNA FLJ31276 fis, clone KIDNE2006376, weakly similar to GAMMA-GLUTAMYLTRANSPEPTIDASE 1 PRECURSOR (EC 2.3.2.2).												0						CCTCTGCCCCAGTGAGGTGTT	0.622000													3	38					0	0	0.004672	0	0	
MAP1D	254042	broad.mit.edu	37	2	172926348	172926348	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr2:172926348C>T	uc002uhk.2	+	2	236	c.163C>T	c.(163-165)CCG>TCG	p.P55S	MAP1D_uc010zdw.1_5'UTR	NM_199227	NP_954697	Q6UB28	AMP1D_HUMAN	methionine aminopeptidase 1D precursor	55					N-terminal protein amino acid modification|peptidyl-methionine modification|proteolysis	mitochondrion	aminopeptidase activity|metal ion binding|metalloexopeptidase activity				0			OV - Ovarian serous cystadenocarcinoma(117;0.216)			TATAGTTTTGCCGGCTGCAGT	0.398000													6	578					0	0	0.001984	0	0	
CHRNA1	1134	broad.mit.edu	37	2	175622707	175622707	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr2:175622707C>A	uc002ujd.2	-	4	354	c.276G>T	c.(274-276)TTG>TTT	p.L92F	uc002uiw.2_Intron|CHRNA1_uc002uje.2_Intron|CHRNA1_uc002ujf.3_Intron	NM_001039523	NP_001034612	P02708	ACHA_HUMAN	nicotinic cholinergic receptor alpha 1 isoform a	92	Extracellular.				muscle cell homeostasis|neuromuscular junction development|neuromuscular process|neuromuscular synaptic transmission|neuron homeostasis|regulation of action potential in neuron|skeletal muscle contraction|skeletal muscle tissue growth	cell junction|cell surface|neuromuscular junction|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			ovary(2)|central_nervous_system(1)|skin(1)	4						aaggaactcccaaagtcacgc	0.174000													3	56					0.004672	0.00482773	0.004672	1	0	
TTN	7273	broad.mit.edu	37	2	179422480	179422480	+	Missense_Mutation	SNP	T	G	G			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr2:179422480T>G	uc010zfg.1	-	277	80121	c.79897A>C	c.(79897-79899)AAA>CAA	p.K26633Q	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.K20328Q|TTN_uc010zfi.1_Missense_Mutation_p.K20261Q|TTN_uc010zfj.1_Missense_Mutation_p.K20136Q	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	27560							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGGTCAGTTTCATGACTTTC	0.418000													63	608					0	0	0.014410	0	0	
SH3BP4	23677	broad.mit.edu	37	2	235951699	235951699	+	Silent	SNP	C	A	A			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr2:235951699C>A	uc002vvp.2	+	4	2679	c.2286C>A	c.(2284-2286)CTC>CTA	p.L762L	SH3BP4_uc010fym.2_Silent_p.L762L|SH3BP4_uc002vvq.2_Silent_p.L762L	NM_014521	NP_055336	Q9P0V3	SH3B4_HUMAN	SH3-domain binding protein 4	762					endocytosis	clathrin-coated vesicle|coated pit|nucleus	protein binding			skin(3)|ovary(1)	4		Breast(86;0.000332)|Renal(207;0.00339)|all_lung(227;0.00458)|all_hematologic(139;0.0296)|Lung NSC(271;0.0419)		Epithelial(121;7.66e-20)|BRCA - Breast invasive adenocarcinoma(100;0.000402)|Lung(119;0.00299)|LUSC - Lung squamous cell carcinoma(224;0.00645)|GBM - Glioblastoma multiforme(43;0.237)		GGACCCTGCTCATGGAGAACA	0.627000													13	55					4.3838e-07	4.79639e-07	0.001855	1	0	
BTBD3	22903	broad.mit.edu	37	20	11899738	11899738	+	Missense_Mutation	SNP	G	T	T			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr20:11899738G>T	uc002wnz.2	+	2	690	c.331G>T	c.(331-333)GCG>TCG	p.A111S	BTBD3_uc002wny.2_Missense_Mutation_p.A50S|BTBD3_uc002woa.2_Missense_Mutation_p.A50S|BTBD3_uc010zrf.1_Intron|BTBD3_uc010zrg.1_5'Flank|BTBD3_uc010zrh.1_5'Flank	NM_014962	NP_055777	Q9Y2F9	BTBD3_HUMAN	BTB/POZ domain containing protein 3 isoform a	111										ovary(2)|central_nervous_system(1)	3						TTATAGAAATGCGATGATGTT	0.438000													11	27					6.40141e-05	6.76513e-05	0.010729	1	0	
BTBD3	22903	broad.mit.edu	37	20	11900476	11900476	+	Silent	SNP	T	A	A			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr20:11900476T>A	uc002wnz.2	+	3	887	c.528T>A	c.(526-528)GCT>GCA	p.A176A	BTBD3_uc002wny.2_Silent_p.A115A|BTBD3_uc002woa.2_Silent_p.A115A|BTBD3_uc010zrf.1_Silent_p.A25A|BTBD3_uc010zrg.1_Silent_p.A25A|BTBD3_uc010zrh.1_Silent_p.A25A	NM_014962	NP_055777	Q9Y2F9	BTBD3_HUMAN	BTB/POZ domain containing protein 3 isoform a	176	BTB.									ovary(2)|central_nervous_system(1)	3						CTTTTCTCGCTATGCTGAAGT	0.418000													36	149					0	0	0.006999	0	0	
BPIL1	80341	broad.mit.edu	37	20	31609144	31609144	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr20:31609144C>T	uc002wyj.2	+	14	1446	c.1252C>T	c.(1252-1254)CTC>TTC	p.L418F		NM_025227	NP_079503	Q8N4F0	BPIL1_HUMAN	bactericidal/permeability-increasing	418						extracellular region	lipid binding			skin(2)|large_intestine(1)|ovary(1)	4						GCTGGACCATCTCAATGGTAA	0.652000													7	42					0	0	0.003080	0	0	
C20orf117	140710	broad.mit.edu	37	20	35422968	35422968	+	Missense_Mutation	SNP	T	C	C			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr20:35422968T>C	uc002xgd.1	-	14	3130	c.2803A>G	c.(2803-2805)AGT>GGT	p.S935G	C20orf117_uc002xge.1_RNA	NM_199181	NP_954650	O94964	K0889_HUMAN	hypothetical protein LOC140710 isoform 2	935											0		Myeloproliferative disorder(115;0.00874)				TCGAGCAAACTTTCAAACTCA	0.507000													70	183					0	0	0.014410	0	0	
SAMHD1	25939	broad.mit.edu	37	20	35555588	35555588	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr20:35555588C>A	uc002xgh.1	-	6	823	c.693G>T	c.(691-693)TGG>TGT	p.W231C		NM_015474	NP_056289	Q9Y3Z3	SAMH1_HUMAN	SAM domain- and HD domain-containing protein 1	231	HD.				defense response to virus|innate immune response|regulation of innate immune response	nucleus	metal ion binding|phosphoric diester hydrolase activity				0		Myeloproliferative disorder(115;0.00878)				TACATACCGTCCATTTCACCT	0.353000													50	149					2.01807e-28	2.31704e-28	0.014410	1	0	
PCNT	5116	broad.mit.edu	37	21	47754527	47754527	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr21:47754527A>G	uc002zji.3	+	3	591	c.484A>G	c.(484-486)AGT>GGT	p.S162G	PCNT_uc002zjj.2_Missense_Mutation_p.S44G|PCNT_uc010gqk.1_RNA	NM_006031	NP_006022	O95613	PCNT_HUMAN	pericentrin	162					cilium assembly|G2/M transition of mitotic cell cycle	cytosol|microtubule	calmodulin binding			ovary(4)|breast(2)|pancreas(2)	8	Breast(49;0.112)					GTTCACAGTCAGTGACCACCC	0.552000													4	162					0	0	0.009096	0	0	
LOC96610	96610	broad.mit.edu	37	22	22664743	22664743	+	RNA	SNP	G	A	A			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr22:22664743G>A	uc011aim.1	+	31		c.2258G>A			LOC96610_uc011aiq.1_RNA					Parts of antibodies, mostly variable regions.												0						CAGACTAAAGGCAAACAAGGA	0.498000													4	49					0	0	0.009096	0	0	
SLC25A20	788	broad.mit.edu	37	3	48896993	48896993	+	Silent	SNP	T	A	A			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr3:48896993T>A	uc003cva.3	-	6	778	c.603A>T	c.(601-603)GGA>GGT	p.G201G	SLC25A20_uc011bbw.1_Silent_p.G151G|SLC25A20_uc010hkj.2_Silent_p.G128G	NM_000387	NP_000378	O43772	MCAT_HUMAN	carnitine/acylcarnitine translocase	201	Cytoplasmic (Potential).				carnitine shuttle|cellular lipid metabolic process|regulation of fatty acid oxidation	integral to membrane|mitochondrial inner membrane	acyl carnitine transporter activity				0				BRCA - Breast invasive adenocarcinoma(193;0.000168)|Kidney(197;0.00231)|KIRC - Kidney renal clear cell carcinoma(197;0.00258)	L-Carnitine(DB00583)	CTCACCTCTTTCCCTCCGGAG	0.433000													12	180					0	0	0.013537	0	0	
RAB6B	51560	broad.mit.edu	37	3	133553468	133553468	+	Silent	SNP	C	A	A			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr3:133553468C>A	uc003epy.2	-	7	894	c.513G>T	c.(511-513)GCG>GCT	p.A171A	RAB6B_uc011blu.1_Silent_p.A158A	NM_016577	NP_057661	Q9NRW1	RAB6B_HUMAN	RAB6B, member RAS oncogene family	171					protein transport|retrograde vesicle-mediated transport, Golgi to ER|small GTPase mediated signal transduction	cytoplasmic membrane-bounded vesicle|Golgi membrane	GTP binding|GTPase activity|protein binding			pancreas(1)	1						GTAGAGCCGACGCCACACGTC	0.502000													36	157					9.62906e-15	1.09208e-14	0.006230	1	0	
C5orf42	65250	broad.mit.edu	37	5	37173906	37173906	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr5:37173906G>A	uc011cpa.1	-	32	6353	c.6122C>T	c.(6121-6123)TCG>TTG	p.S2041L	C5orf42_uc011coy.1_Missense_Mutation_p.S541L|C5orf42_uc003jks.2_RNA|C5orf42_uc011coz.1_Missense_Mutation_p.S1116L|C5orf42_uc003jkr.1_Missense_Mutation_p.S74L	NM_023073	NP_075561	E9PH94	E9PH94_HUMAN	hypothetical protein LOC65250	2041										ovary(4)|breast(2)|skin(1)	7	all_lung(31;0.000616)		COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.177)|Colorectal(62;0.202)			AACGGACTCCGAACAATCTGG	0.403000													33	217					0	0	0.015359	0	0	
SFRS12	140890	broad.mit.edu	37	5	65465970	65465970	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr5:65465970C>T	uc003juo.2	+	9	1405	c.745C>T	c.(745-747)CGG>TGG	p.R249W	SFRS12_uc003jun.2_Missense_Mutation_p.R365W|SFRS12_uc010iwy.2_Missense_Mutation_p.R249W	NM_139168	NP_631907	Q8WXA9	SREK1_HUMAN	splicing factor, arginine/serine-rich 12 isoform	249	Arg/Glu/Lys/Ser-rich.				mRNA processing|RNA splicing	spliceosomal complex	nucleic acid binding|nucleotide binding|protein binding				0		Lung NSC(167;9.34e-06)|Prostate(74;0.00187)|Ovarian(174;0.0545)|Breast(144;0.0928)|Colorectal(97;0.234)		Lung(70;0.00449)		AAGGGAGAGACGGAAGTCAAG	0.368000													16	44					0	0	0.008871	0	0	
TRPC7	57113	broad.mit.edu	37	5	135692752	135692752	+	Silent	SNP	G	A	A			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr5:135692752G>A	uc003lbn.1	-	1	324	c.321C>T	c.(319-321)GAC>GAT	p.D107D	TRPC7_uc010jef.1_Silent_p.D99D|TRPC7_uc010jeg.1_RNA|TRPC7_uc010jeh.1_Silent_p.D99D|TRPC7_uc010jei.1_Silent_p.D99D|TRPC7_uc010jej.1_Translation_Start_Site	NM_020389	NP_065122	Q9HCX4	TRPC7_HUMAN	transient receptor potential cation channel,	108	Cytoplasmic (Potential).|ANK 3.				axon guidance|platelet activation	integral to membrane|plasma membrane	calcium channel activity|protein binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GCAGCAGCGCGTCCCCCACCC	0.667000													41	88					0	0	0.008740	0	0	
ANKHD1-EIF4EBP3	404734	broad.mit.edu	37	5	139838894	139838894	+	Silent	SNP	A	G	G			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr5:139838894A>G	uc003lfs.1	+	9	1750	c.1626A>G	c.(1624-1626)GCA>GCG	p.A542A	ANKHD1_uc003lfq.1_Silent_p.A542A|ANKHD1_uc003lfr.2_Silent_p.A542A|ANKHD1_uc003lft.1_Silent_p.A3A|ANKHD1_uc003lfu.1_Silent_p.A3A|ANKHD1_uc003lfp.2_Silent_p.A531A|ANKHD1_uc003lfo.2_Silent_p.A542A|ANKHD1_uc010jfk.2_Silent_p.A542A	NM_020690	NP_065741	Q8IWZ2	Q8IWZ2_HUMAN	ANKHD1-EIF4EBP3 protein	542						cytoplasm|nucleus	RNA binding			ovary(6)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TGATGGAGGCATCTCAGGAGG	0.383000													20	134					0	0	0.012319	0	0	
PCDHB18	54660	broad.mit.edu	37	5	140615963	140615963	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr5:140615963G>A	uc003ljc.1	+	1	2026	c.1678G>A	c.(1678-1680)GGG>AGG	p.G560R		NR_001281				SubName: Full=Similar to protocadherin-3 (Pcdh3);											ovary(1)	1						CACGGAGCCCGGGCTGTTCGG	0.711000													33	136					0	0	0.007835	0	0	
NOTCH4	4855	broad.mit.edu	37	6	32163246	32163246	+	Missense_Mutation	SNP	G	A	A			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr6:32163246G>A	uc003obb.2	-	30	6119	c.5980C>T	c.(5980-5982)CCC>TCC	p.P1994S	GPSM3_uc003oax.3_5'Flank|GPSM3_uc003oay.3_5'Flank|GPSM3_uc003oaz.2_5'UTR|NOTCH4_uc011dpt.1_3'UTR|NOTCH4_uc003oba.2_Missense_Mutation_p.P654S|NOTCH4_uc011dpu.1_RNA|NOTCH4_uc011dpv.1_RNA	NM_004557	NP_004548	Q99466	NOTC4_HUMAN	notch4 preproprotein	1994	Cytoplasmic (Potential).				cell fate determination|embryo development|hemopoiesis|mammary gland development|negative regulation of endothelial cell differentiation|Notch receptor processing|Notch signaling pathway|patterning of blood vessels|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cell surface|cytosol|endoplasmic reticulum lumen|extracellular region|Golgi lumen|integral to plasma membrane|nucleoplasm	calcium ion binding|protein heterodimerization activity|receptor activity			lung(8)|ovary(5)|breast(4)|central_nervous_system(3)|upper_aerodigestive_tract(1)|skin(1)	22						TGGTTTATGGGCATTTCTTGG	0.512000													4	219					0	0	0.009096	0	0	
TEAD3	7005	broad.mit.edu	37	6	35443212	35443212	+	Silent	SNP	C	T	T			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr6:35443212C>T	uc003oku.3	-	12	1331	c.1095G>A	c.(1093-1095)TCG>TCA	p.S365S	TEAD3_uc003okt.2_Silent_p.S254S|TEAD3_uc010jvx.2_Silent_p.S305S	NM_003214	NP_003205	Q99594	TEAD3_HUMAN	TEA domain family member 3	365	Transcriptional activation (Potential).				female pregnancy|hippo signaling cascade		DNA binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						CGCACATGGGCGAGCGGTGGA	0.562000													18	81					0	0	0.012319	0	0	
MUT	4594	broad.mit.edu	37	6	49399498	49399498	+	Silent	SNP	G	T	T			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr6:49399498G>T	uc003ozg.3	-	13	2451	c.2196C>A	c.(2194-2196)GCC>GCA	p.A732A		NM_000255	NP_000246	P22033	MUTA_HUMAN	methylmalonyl Coenzyme A mutase precursor	732	B12-binding.				fatty acid beta-oxidation	mitochondrial matrix	cobalamin binding|metal ion binding|methylmalonyl-CoA mutase activity				0	Lung NSC(77;0.0376)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	GCACCTGAACGGCAGCCTTTG	0.333000													11	398					0.00010058	0.0001051	0.013537	1	0	
MUT	4594	broad.mit.edu	37	6	49399501	49399501	+	Silent	SNP	A	C	C			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr6:49399501A>C	uc003ozg.3	-	13	2448	c.2193T>G	c.(2191-2193)GCT>GCG	p.A731A		NM_000255	NP_000246	P22033	MUTA_HUMAN	methylmalonyl Coenzyme A mutase precursor	731	B12-binding.				fatty acid beta-oxidation	mitochondrial matrix	cobalamin binding|metal ion binding|methylmalonyl-CoA mutase activity				0	Lung NSC(77;0.0376)				Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	CCTGAACGGCAGCCTTTGGAA	0.338000													12	398					0	0	0.013537	0	0	
BMP5	653	broad.mit.edu	37	6	55638953	55638953	+	Silent	SNP	C	T	T			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr6:55638953C>T	uc003pcq.2	-	4	1633	c.921G>A	c.(919-921)GCG>GCA	p.A307A	BMP5_uc011dxf.1_Silent_p.A307A	NM_021073	NP_066551	P22003	BMP5_HUMAN	bone morphogenetic protein 5 preproprotein	307					cartilage development|cell differentiation|growth|ossification	extracellular space	BMP receptor binding|cytokine activity|growth factor activity			ovary(2)	2	Lung NSC(77;0.0462)		LUSC - Lung squamous cell carcinoma(124;0.181)			GTACCTCACTCGCCTTGAAGA	0.468000													20	204					0	0	0.008871	0	0	
ABCA13	154664	broad.mit.edu	37	7	48313582	48313582	+	Nonsense_Mutation	SNP	G	A	A			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr7:48313582G>A	uc003toq.2	+	17	4344	c.4319G>A	c.(4318-4320)TGG>TAG	p.W1440*	ABCA13_uc010kyr.2_Nonsense_Mutation_p.W943*	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	1440					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						ATTGTAACTTGGGTGTTAAAT	0.269000													6	38					0	0	0.001168	0	0	
Unknown	0	broad.mit.edu	37	7	64528850	64528850	+	RNA	SNP	T	G	G	rs2949472	by1000genomes	TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr7:64528850T>G	uc003ttt.1	+	5		c.644T>G			uc010kzt.1_RNA|uc003ttu.1_5'Flank					Homo sapiens cDNA clone IMAGE:4215179, partial cds.																		GAATTCTGGCTTTTTTTACAA	0.284000													3	35					0	0	0.009096	0	0	
FAM115C	285966	broad.mit.edu	37	7	143417214	143417214	+	Silent	SNP	T	G	G			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr7:143417214T>G	uc003wdf.2	+	3	1145	c.1062T>G	c.(1060-1062)GGT>GGG	p.G354G	FAM115C_uc003wdg.2_Silent_p.G73G|FAM115C_uc011ktk.1_Silent_p.G354G|FAM115C_uc003wdh.2_Silent_p.G354G|FAM115C_uc011ktm.1_Silent_p.G354G|uc011ktn.1_Intron|uc011kto.1_Intron|uc011ktp.1_Intron|LOC154761_uc011ktq.1_Intron|LOC154761_uc011ktr.1_Intron|LOC154761_uc011kts.1_Intron|FAM115C_uc011ktt.1_Silent_p.G190G|FAM115C_uc003wdi.1_Silent_p.G73G	NM_001130025	NP_001123497	A6NFQ2	F115C_HUMAN	hypothetical protein LOC285966 isoform A	354											0						TGGCTGAGGGTGGGGGGCTGC	0.617000													6	81					0	0	0.013537	0	0	
CSMD1	64478	broad.mit.edu	37	8	3165968	3165968	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr8:3165968C>T	uc011kwk.1	-	24	4082	c.3692G>A	c.(3691-3693)CGT>CAT	p.R1231H	CSMD1_uc011kwj.1_Missense_Mutation_p.R623H|CSMD1_uc003wqe.2_Missense_Mutation_p.R387H	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1231	Extracellular (Potential).|Sushi 7.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GCCTTCATCACGGATCCTATA	0.512000													18	42					0	0	0.007413	0	0	
NEFM	4741	broad.mit.edu	37	8	24771859	24771859	+	Missense_Mutation	SNP	C	A	A			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr8:24771859C>A	uc003xed.3	+	1	586	c.553C>A	c.(553-555)CTC>ATC	p.L185I	NEFM_uc011lac.1_Missense_Mutation_p.L185I|NEFM_uc010lue.2_5'Flank|uc010luc.1_Missense_Mutation_p.S70I	NM_005382	NP_005373	P07197	NFM_HUMAN	neurofilament, medium polypeptide 150kDa isoform	185	Rod.|Coil 1B.					neurofilament	protein binding|structural constituent of cytoskeleton			breast(1)	1		Prostate(55;0.157)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0197)|Epithelial(17;2.44e-10)|Colorectal(74;0.0108)|COAD - Colon adenocarcinoma(73;0.0375)		CATCCACCGGCTCAAGGAGCG	0.657000													7	67					1.12685e-05	1.21857e-05	0.004482	1	0	
KCNU1	157855	broad.mit.edu	37	8	36768479	36768479	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr8:36768479C>T	uc010lvw.2	+	22	2450	c.2363C>T	c.(2362-2364)GCG>GTG	p.A788V	KCNU1_uc003xjw.2_RNA	NM_001031836	NP_001027006	A8MYU2	KCNU1_HUMAN	potassium channel, subfamily U, member 1	788	Cytoplasmic (Potential).					voltage-gated potassium channel complex	binding|large conductance calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(67;0.0504)|Kidney(114;0.0634)		GACCTCCATGCGGCCAACATA	0.522000													58	165					0	0	0.014410	0	0	
EFR3A	23167	broad.mit.edu	37	8	132980566	132980566	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr8:132980566C>G	uc003yte.2	+	9	1081	c.880C>G	c.(880-882)CAG>GAG	p.Q294E		NM_015137	NP_055952	Q14156	EFR3A_HUMAN	EFR3 homolog A	294						plasma membrane	binding			ovary(3)|breast(1)|central_nervous_system(1)	5	Esophageal squamous(12;0.00693)|Ovarian(258;0.00769)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000805)|LUAD - Lung adenocarcinoma(14;0.102)			CCATGTGATCCAGGAGATTCT	0.413000													13	41					0	0	0.013537	0	0	
SLC45A4	57210	broad.mit.edu	37	8	142228731	142228731	+	Silent	SNP	G	A	A			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr8:142228731G>A	uc003ywd.1	-	4	1163	c.855C>T	c.(853-855)CAC>CAT	p.H285H	SLC45A4_uc003ywc.1_Silent_p.H285H|SLC45A4_uc010meq.1_Silent_p.H283H	NM_001080431	NP_001073900	Q5BKX6	S45A4_HUMAN	solute carrier family 45, member 4	336					transport	integral to membrane				ovary(2)	2	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			AGGAGGCGTCGTGGAAGATGG	0.677000													50	94					0	0	0.014410	0	0	
ZNF484	83744	broad.mit.edu	37	9	95608610	95608610	+	Missense_Mutation	SNP	C	G	G			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr9:95608610C>G	uc004asu.1	-	5	2608	c.2459G>C	c.(2458-2460)AGT>ACT	p.S820T	ANKRD19_uc004asr.3_Intron|ZNF484_uc011lub.1_Missense_Mutation_p.S822T|ZNF484_uc010mrb.1_Missense_Mutation_p.S784T|ZNF484_uc004asv.1_Missense_Mutation_p.S784T	NM_031486	NP_113674	Q5JVG2	ZN484_HUMAN	zinc finger protein 484 isoform a	820					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTGAGGCATACTGAGTTGTGG	0.423000													27	457					0	0	0.008740	0	0	
LMX1B	4010	broad.mit.edu	37	9	129455583	129455583	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr9:129455583C>T	uc004bqj.2	+	4	703	c.653C>T	c.(652-654)TCG>TTG	p.S218L	LMX1B_uc004bqi.2_Missense_Mutation_p.S218L|LMX1B_uc011maa.1_Missense_Mutation_p.S218L	NM_002316	NP_002307	O60663	LMX1B_HUMAN	LIM homeobox transcription factor 1, beta	218	Homeobox.		S -> P (in NPS).		dorsal/ventral pattern formation|in utero embryonic development	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						TTCGAGGTCTCGTCGAAGCCT	0.587000									Nail-Patella_Syndrome				7	29					0	0	0.003080	0	0	
SH3KBP1	30011	broad.mit.edu	37	X	19560206	19560206	+	Missense_Mutation	SNP	A	G	G			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chrX:19560206A>G	uc004czm.2	-	16	2045	c.1729T>C	c.(1729-1731)TCT>CCT	p.S577P	SH3KBP1_uc011mje.1_Missense_Mutation_p.S316P|SH3KBP1_uc011mjf.1_Missense_Mutation_p.S339P|SH3KBP1_uc004czl.2_Missense_Mutation_p.S540P|SH3KBP1_uc010nfm.2_Missense_Mutation_p.S22P	NM_031892	NP_114098	Q96B97	SH3K1_HUMAN	SH3-domain kinase binding protein 1 isoform a	577					apoptosis|cell-cell signaling|endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	cytoplasmic vesicle membrane|cytoskeleton|cytosol|focal adhesion|nucleus|synapse|synaptosome	SH3 domain binding				0						GTTCCCAAAGAGGATGACAGG	0.657000													31	164					0	0	0.003755	0	0	
KLHL15	80311	broad.mit.edu	37	X	24024572	24024572	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chrX:24024572G>C	uc004dba.3	-	3	495	c.239C>G	c.(238-240)ACC>AGC	p.T80S		NM_030624	NP_085127	Q96M94	KLH15_HUMAN	kelch-like 15	80	BTB.									ovary(1)|breast(1)	2						GCTGAAACCGGTAGCTGTTAG	0.413000													32	211					0	0	0.009535	0	0	
DMD	1756	broad.mit.edu	37	X	31152236	31152236	+	Missense_Mutation	SNP	G	C	C			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chrX:31152236G>C	uc004dda.1	-	77	11241	c.10997C>G	c.(10996-10998)TCC>TGC	p.S3666C	DMD_uc004dcq.1_Missense_Mutation_p.S937C|DMD_uc004dcr.1_Missense_Mutation_p.S1086C|DMD_uc004dcs.1_Missense_Mutation_p.S1096C|DMD_uc004dct.1_Missense_Mutation_p.S1206C|DMD_uc004dcu.1_Missense_Mutation_p.S1206C|DMD_uc004dcv.1_Missense_Mutation_p.S1193C|DMD_uc004dcw.2_Missense_Mutation_p.S2322C|DMD_uc004dcx.2_Missense_Mutation_p.S2325C|DMD_uc004dcz.2_Missense_Mutation_p.S3543C|DMD_uc004dcy.1_Missense_Mutation_p.S3662C|DMD_uc004ddb.1_Missense_Mutation_p.S3658C|DMD_uc004dcm.1_Missense_Mutation_p.S598C|DMD_uc004dcn.1_Missense_Mutation_p.S585C|DMD_uc004dco.1_Missense_Mutation_p.S598C|DMD_uc004dcp.1_Missense_Mutation_p.S585C|DMD_uc011mkb.1_Missense_Mutation_p.S488C	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	3666					muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				ACTAGGGAAGGAGTTGTTGAG	0.468000													14	58					0	0	0.006122	0	0	
CCNB3	85417	broad.mit.edu	37	X	50052274	50052274	+	Missense_Mutation	SNP	T	A	A			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chrX:50052274T>A	uc004dox.3	+	6	1403	c.1105T>A	c.(1105-1107)TTT>ATT	p.F369I	CCNB3_uc004doy.2_Missense_Mutation_p.F369I|CCNB3_uc004doz.2_Intron|CCNB3_uc010njq.2_Intron	NM_033031	NP_149020	Q8WWL7	CCNB3_HUMAN	cyclin B3 isoform 3	369					cell division|meiosis|regulation of cyclin-dependent protein kinase activity|regulation of G2/M transition of mitotic cell cycle	nucleus	protein kinase binding			ovary(4)|lung(3)|large_intestine(1)|pancreas(1)	9	Ovarian(276;0.236)					GTCGTTAGCCTTTAAGAAGAA	0.458000													17	126					0	0	0.014323	0	0	
TSIX	9383	broad.mit.edu	37	X	73043833	73043833	+	RNA	SNP	G	C	C			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chrX:73043833G>C	uc004ebn.2	+	1		c.31794G>C			XIST_uc004ebm.1_RNA	NR_003255				Homo sapiens XIST antisense RNA (non-protein coding) (TSIX), non-coding RNA.												0						TCTACACATAGATCTCTGTTG	0.363000													3	25					0	0	0.004672	0	0	
ATP7A	538	broad.mit.edu	37	X	77245137	77245137	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chrX:77245137C>T	uc004ecx.3	+	4	1179	c.1019C>T	c.(1018-1020)CCG>CTG	p.P340L	ATP7A_uc004ecw.2_Missense_Mutation_p.P340L	NM_000052	NP_000043	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	340	HMA 3.|Cytoplasmic (Potential).				ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity				0						GCTGTATCACCGGGGCTATAT	0.423000													27	349					0	0	0.003954	0	0	
RPS6KA6	27330	broad.mit.edu	37	X	83351320	83351320	+	Splice_Site	SNP	C	T	T			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chrX:83351320C>T	uc004eej.1	-	20	1931	c.1854_splice	c.e20-1	p.G618_splice	RPS6KA6_uc011mqt.1_Splice_Site_p.G618_splice|RPS6KA6_uc011mqu.1_Splice_Site_p.G515_splice	NM_014496	NP_055311	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase polypeptide 6						axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			lung(5)|stomach(1)|central_nervous_system(1)|skin(1)	8						TGGAGTGTAGCTATTAATAAA	0.348000													15	51					0	0	0.004007	0	0	
GABRA3	2556	broad.mit.edu	37	X	151424320	151424320	+	Missense_Mutation	SNP	C	T	T			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chrX:151424320C>T	uc010ntk.1	-	5	721	c.481G>A	c.(481-483)GCT>ACT	p.A161T		NM_000808	NP_000799	P34903	GBRA3_HUMAN	gamma-aminobutyric acid A receptor, alpha 3	161	Extracellular (Probable).				gamma-aminobutyric acid signaling pathway	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|protein binding			ovary(1)	1	Acute lymphoblastic leukemia(192;6.56e-05)				Alprazolam(DB00404)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	ATGTTATGAGCCACTGATTTC	0.493000													72	245					0	0	0.014410	0	0	
ACVR1B	91	broad.mit.edu	37	12	52377884	52377884	+	Frame_Shift_Del	DEL	A	-	-			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr12:52377884delA	uc001rzn.2	+	5	955	c.913delA	c.(913-915)ATTfs	p.I305fs	ACVR1B_uc001rzl.2_Frame_Shift_Del_p.I305fs|ACVR1B_uc001rzm.2_Frame_Shift_Del_p.I305fs|ACVR1B_uc010snn.1_Frame_Shift_Del_p.I346fs	NM_004302	NP_004293	P36896	ACV1B_HUMAN	activin A receptor, type IB isoform a precursor	305	Protein kinase.|Cytoplasmic (Potential).				G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|peptidyl-threonine phosphorylation|positive regulation of activin receptor signaling pathway|positive regulation of erythrocyte differentiation|protein autophosphorylation|transmembrane receptor protein serine/threonine kinase signaling pathway	cell surface	activin receptor activity, type I|ATP binding|metal ion binding|SMAD binding|transforming growth factor beta receptor activity|ubiquitin protein ligase binding			pancreas(4)|breast(2)|ovary(1)|lung(1)|kidney(1)	9				BRCA - Breast invasive adenocarcinoma(357;0.104)	Adenosine triphosphate(DB00171)	TGAGGGGATGATTAAGCTGGC	0.547													23	53	---	---	---	---						.
DUOXA1	90527	broad.mit.edu	37	15	45409999	45409999	+	Frame_Shift_Del	DEL	C	-	-			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr15:45409999delC	uc001zup.2	-	11	1566	c.1166delG	c.(1165-1167)CGCfs	p.R389fs	DUOXA2_uc001zuo.2_Frame_Shift_Del_p.S285fs|DUOXA2_uc010beb.2_RNA|DUOXA1_uc010uem.1_Frame_Shift_Del_p.R344fs|DUOXA1_uc010bec.2_Frame_Shift_Del_p.R389fs	NM_144565	NP_653166	Q1HG43	DOXA1_HUMAN	Numb-interacting protein	Error:Variant_position_missing_in_Q1HG43_after_alignment					protein transport	endoplasmic reticulum membrane|integral to membrane				ovary(1)	1		all_cancers(109;6.02e-08)|all_epithelial(112;1.83e-06)|Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;3.82e-18)|GBM - Glioblastoma multiforme(94;4.39e-07)|COAD - Colon adenocarcinoma(120;0.0676)|Colorectal(133;0.0686)		TGGACCAAAGCGCCAAGGACT	0.617											OREG0023102	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	69	132	---	---	---	---						.
STX10	8677	broad.mit.edu	37	19	13259888	13259889	+	Frame_Shift_Ins	INS	-	ATAT	ATAT			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr19:13259888_13259889insATAT	uc010xnb.1	-	4	317_318	c.317_318insATAT	c.(316-318)ATGfs	p.M106fs	STX10_uc002mwn.2_Frame_Shift_Ins_p.M5fs|STX10_uc002mwo.2_Frame_Shift_Ins_p.M5fs|STX10_uc010xna.1_Intron|STX10_uc010xnc.1_Intron|IER2_uc002mwr.2_5'Flank	NM_003765	NP_003756	O60499	STX10_HUMAN	syntaxin 10	106	Cytoplasmic (Potential).				Golgi vesicle transport|intracellular protein transport|retrograde transport, endosome to Golgi	Golgi membrane|integral to membrane	SNAP receptor activity				0			OV - Ovarian serous cystadenocarcinoma(19;3.41e-21)			TTGGGCTGACCATATGGTCCTT	0.416													11	20	---	---	---	---						.
THBD	7056	broad.mit.edu	37	20	23029226	23029229	+	Frame_Shift_Del	DEL	AGGA	-	-			TCGA-CG-4477-01A-01D-1158-08	TCGA-CG-4477-10A-01D-1158-08									Somatic	Phase_I	Capture				Illumina GAIIx	b90e44b2-1ae5-47dd-b979-81612daaf3db	02d6b265-8620-4a55-b3c5-84d930b65532	g.chr20:23029226_23029229delAGGA	uc002wss.2	-	1	1073_1076	c.913_916delTCCT	c.(913-918)TCCTACfs	p.S305fs	THBD_uc002wst.1_5'Flank|THBD_uc002wsu.1_Frame_Shift_Del_p.S246fs	NM_000361	NP_000352	P07204	TRBM_HUMAN	thrombomodulin precursor	305_306	EGF-like 2.|Extracellular (Potential).				blood coagulation|leukocyte migration|negative regulation of fibrinolysis|negative regulation of platelet activation	cell surface|integral to plasma membrane	calcium ion binding|protein binding|transmembrane receptor activity				0	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)				Drotrecogin alfa(DB00055)	ATGCACGAGTAGGAGCCCGGCTGG	0.686													18	38	---	---	---	---						.
