Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut	init_n_lod
ZBTB8A	653121	broad.mit.edu	37	1	33060694	33060694	+	Missense_Mutation	SNP	C	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr1:33060694C>A	uc001bvn.2	+	4	1348	c.863C>A	c.(862-864)ACA>AAA	p.T288K	ZBTB8A_uc001bvk.2_RNA|ZBTB8A_uc001bvm.2_Missense_Mutation_p.T288K	NM_001040441	NP_001035531	Q96BR9	ZBT8A_HUMAN	zinc finger and BTB domain containing 8A	288	C2H2-type 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCGTACTGCACACATGTGGTG	0.453000													28	67					1.42536e-11	1.62692e-11	0.099896	1	0	
TMEM125	128218	broad.mit.edu	37	1	43738884	43738884	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr1:43738884G>A	uc001cir.2	+	4	1061	c.491G>A	c.(490-492)GGC>GAC	p.G164D	EBNA1BP2_uc001cio.2_5'Flank|TMEM125_uc001cis.2_Missense_Mutation_p.G164D	NM_144626	NP_653227	Q96AQ2	TM125_HUMAN	transmembrane protein 125	164	Helical; (Potential).					integral to membrane				breast(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				TTGCTGCTGGGCCTGCTGCTG	0.677000													5	38					0	0	0.014758	0	0	
NASP	4678	broad.mit.edu	37	1	46073520	46073520	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr1:46073520G>A	uc001coi.1	+	6	1039	c.937G>A	c.(937-939)GAG>AAG	p.E313K	NASP_uc010olq.1_Missense_Mutation_p.E276K|NASP_uc001coh.1_Missense_Mutation_p.E315K|NASP_uc001coj.1_Intron|NASP_uc010olr.1_Missense_Mutation_p.E249K|NASP_uc001cok.1_Missense_Mutation_p.E196K	NM_002482	NP_002473	P49321	NASP_HUMAN	nuclear autoantigenic sperm protein isoform 2	313	Glu-rich (acidic).				blastocyst development|cell cycle|cell proliferation|DNA replication|histone exchange|protein transport	cytoplasm|nucleus	Hsp90 protein binding			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.211)					GGGTGGGGACGAGCCAGAGGA	0.532000													12	55					0	0	0.080935	0	0	
IFI44L	10964	broad.mit.edu	37	1	79093939	79093939	+	Silent	SNP	G	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr1:79093939G>T	uc010oro.1	+	2	518	c.339G>T	c.(337-339)GTG>GTT	p.V113V	IFI44L_uc010orp.1_Intron|IFI44L_uc010orq.1_Intron	NM_006820	NP_006811	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like	113						cytoplasm					0						AGCAACTGGTGTGTCGTTTAT	0.299000													4	41					0.00024832	0.000253938	0.150653	1	0	
EVI5	7813	broad.mit.edu	37	1	92979379	92979379	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr1:92979379C>T	uc001dox.2	-	18	2277	c.2267G>A	c.(2266-2268)GGT>GAT	p.G756D	EVI5_uc010otf.1_Missense_Mutation_p.G767D	NM_005665	NP_005656	O60447	EVI5_HUMAN	ecotropic viral integration site 5	756	Targeting to the centrosomes.|Interaction with AURKB and INCENP.				cell cycle|cell division|cell proliferation|multicellular organismal development	microtubule organizing center|nucleus|spindle	protein binding|Rab GTPase activator activity			ovary(1)|breast(1)	2		all_lung(203;0.00146)|Lung NSC(277;0.00565)|all_neural(321;0.185)|Melanoma(281;0.193)|Glioma(108;0.203)		Epithelial(280;8.09e-25)|OV - Ovarian serous cystadenocarcinoma(397;1.27e-22)|all cancers(265;1.74e-21)|GBM - Glioblastoma multiforme(16;0.00233)|BRCA - Breast invasive adenocarcinoma(282;0.211)		CAAAGGAAAACCAACACCAGT	0.438000													9	96					0	0	0.047766	0	0	
VAV3	10451	broad.mit.edu	37	1	108145689	108145689	+	Silent	SNP	T	C	C			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr1:108145689T>C	uc001dvk.1	-	23	2166	c.2112A>G	c.(2110-2112)GGA>GGG	p.G704G	VAV3_uc010ouu.1_Silent_p.G108G|VAV3_uc001dvj.1_Silent_p.G144G|VAV3_uc010ouv.1_Silent_p.G108G|VAV3_uc010ouw.1_Silent_p.G704G	NM_006113	NP_006104	Q9UKW4	VAV3_HUMAN	vav 3 guanine nucleotide exchange factor isoform	704	SH2.				angiogenesis|apoptosis|B cell receptor signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|platelet activation|positive regulation of B cell proliferation|regulation of Rho protein signal transduction|response to DNA damage stimulus|response to drug|small GTPase mediated signal transduction	cytosol	GTPase activator activity|metal ion binding|SH3/SH2 adaptor activity			ovary(5)|lung(2)|breast(2)	9		all_epithelial(167;5.38e-05)|all_lung(203;0.000314)|Lung NSC(277;0.000594)		Colorectal(144;0.0331)|Lung(183;0.128)|Epithelial(280;0.204)		TTGCATATTCTCCTGACTCTT	0.373000													22	91					0	0	0.083992	0	0	
KCND3	3752	broad.mit.edu	37	1	112525240	112525240	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr1:112525240G>A	uc001ebu.1	-	2	589	c.109C>T	c.(109-111)CGG>TGG	p.R37W	KCND3_uc001ebv.1_Missense_Mutation_p.R37W	NM_004980	NP_004971	Q9UK17	KCND3_HUMAN	potassium voltage-gated channel, Shal-related	37	Cytoplasmic (Potential).					sarcolemma|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|metal ion binding			ovary(2)|large_intestine(1)	3		all_cancers(81;8.52e-06)|all_epithelial(167;5.65e-06)|all_lung(203;2.72e-05)|Lung NSC(69;4.56e-05)		all cancers(265;0.056)|Lung(183;0.0576)|Colorectal(144;0.1)|Epithelial(280;0.104)|COAD - Colon adenocarcinoma(174;0.222)|LUSC - Lung squamous cell carcinoma(189;0.231)		TCATCCTGCCGCTTGTTCTTG	0.682000													12	41					0	0	0.105934	0	0	
SYT6	148281	broad.mit.edu	37	1	114640394	114640394	+	Silent	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr1:114640394G>A	uc001eev.2	-	6	1465	c.1215C>T	c.(1213-1215)ATC>ATT	p.I405I	SYT6_uc001eeu.2_Silent_p.I50I	NM_205848	NP_995320	Q5T7P8	SYT6_HUMAN	synaptotagmin VI	490	Cytoplasmic (Potential).|Necessary for cell membrane association (isoform 2) (By similarity).				acrosomal vesicle exocytosis	cell junction|cytosol|integral to membrane|perinuclear endoplasmic reticulum|peripheral to membrane of membrane fraction|synaptic vesicle membrane	clathrin binding|metal ion binding|protein homodimerization activity|syntaxin binding|transporter activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5	Lung SC(450;0.184)	all_cancers(81;4.41e-08)|all_epithelial(167;5.18e-08)|all_lung(203;1.58e-05)|Lung NSC(69;2.82e-05)		Lung(183;0.0234)|Colorectal(144;0.0686)|all cancers(265;0.0792)|Epithelial(280;0.0866)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GCCAGTGTGCGATGGGCTTCC	0.577000													17	77					0	0	0.175082	0	0	
SPAG17	200162	broad.mit.edu	37	1	118538991	118538991	+	Splice_Site	SNP	A	C	C	rs140829839		TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr1:118538991A>C	uc001ehk.2	-	34	5121	c.5053_splice	c.e34+1	p.G1685_splice		NM_206996	NP_996879	Q6Q759	SPG17_HUMAN	sperm associated antigen 17							cilium|flagellar axoneme|microtubule				upper_aerodigestive_tract(2)|ovary(2)|large_intestine(1)|skin(1)	6	Esophageal squamous(2;0.0106)	all_cancers(81;0.0204)|all_lung(203;9.46e-05)|Lung NSC(69;0.000675)|all_epithelial(167;0.01)		Lung(183;0.0858)		TGGGTCCTCTACCTGGCTGTT	0.423000													20	63					0	0	0.043863	0	0	
PPIAL4E	730262	broad.mit.edu	37	1	148644440	148644440	+	Missense_Mutation	SNP	A	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr1:148644440A>T	uc010paz.1	+	1	430	c.355A>T	c.(355-357)ACT>TCT	p.T119S		NM_001144032	NP_001137504	F5H284	F5H284_HUMAN	peptidylprolyl isomerase A (cyclophilin A)-like	119					protein folding		peptidyl-prolyl cis-trans isomerase activity				0						TGCTGCCAAGACTGAGTGGTT	0.488000													43	122					0	0	0.139131	0	0	
FLG	2312	broad.mit.edu	37	1	152275264	152275264	+	Missense_Mutation	SNP	T	C	C			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr1:152275264T>C	uc001ezu.1	-	3	12134	c.12098A>G	c.(12097-12099)AAT>AGT	p.N4033S		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	4033					keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGGGTCCTTATTAATATACGT	0.353000									Ichthyosis				18	73					0	0	0.043863	0	0	
OR6K6	128371	broad.mit.edu	37	1	158725554	158725554	+	Missense_Mutation	SNP	T	C	C			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr1:158725554T>C	uc001fsw.1	+	1	949	c.949T>C	c.(949-951)TAT>CAT	p.Y317H		NM_001005184	NP_001005184	Q8NGW6	OR6K6_HUMAN	olfactory receptor, family 6, subfamily K,	317	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_hematologic(112;0.0378)					CCCCATCATCTATAGCCTGAA	0.443000													5	82					0	0	0.021553	0	0	
OR10J1	26476	broad.mit.edu	37	1	159410409	159410409	+	Silent	SNP	C	G	G			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr1:159410409C>G	uc010piv.1	+	1	861	c.861C>G	c.(859-861)ACC>ACG	p.T287T	uc001fts.3_Intron	NM_012351	NP_036483	P30954	O10J1_HUMAN	olfactory receptor, family 10, subfamily J,	287	Helical; Name=7; (Potential).				sensory perception of smell|single fertilization	integral to plasma membrane	olfactory receptor activity			ovary(1)	1	all_hematologic(112;0.0429)					TCTCGGTGACCTACACTGTCA	0.507000													19	82					0	0	0.043863	0	0	
NME7	29922	broad.mit.edu	37	1	169200055	169200055	+	Silent	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr1:169200055G>A	uc001gfu.2	-	10	1129	c.891C>T	c.(889-891)GAC>GAT	p.D297D	NME7_uc010plq.1_RNA|NME7_uc001gft.2_Silent_p.D261D	NM_013330	NP_037462	Q9Y5B8	NDK7_HUMAN	nucleoside diphosphate kinase 7 isoform a	297					CTP biosynthetic process|GTP biosynthetic process|UTP biosynthetic process	centrosome	ATP binding|metal ion binding|nucleoside diphosphate kinase activity			central_nervous_system(1)	1	all_hematologic(923;0.208)					CTGTCACCATGTCCTATGATA	0.249000													8	37					0	0	0.038147	0	0	
KIFAP3	22920	broad.mit.edu	37	1	170015873	170015873	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr1:170015873C>T	uc001ggv.2	-	3	570	c.299G>A	c.(298-300)CGT>CAT	p.R100H	KIFAP3_uc010ply.1_Translation_Start_Site|KIFAP3_uc001ggw.1_Missense_Mutation_p.R56H	NM_014970	NP_055785	Q92845	KIFA3_HUMAN	kinesin-associated protein 3	100					blood coagulation|plus-end-directed vesicle transport along microtubule|protein complex assembly|signal transduction	centrosome|condensed nuclear chromosome|cytosol|endoplasmic reticulum|kinesin II complex|spindle microtubule	kinesin binding			skin(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CAATGAATCACGGCGGTTCTG	0.368000													23	126					0	0	0.091800	0	0	
ESRRG	2104	broad.mit.edu	37	1	216692635	216692635	+	Missense_Mutation	SNP	T	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr1:216692635T>A	uc001hkw.1	-	6	1157	c.991A>T	c.(991-993)ATA>TTA	p.I331L	ESRRG_uc001hky.1_Missense_Mutation_p.I308L|ESRRG_uc009xdp.1_Missense_Mutation_p.I308L|ESRRG_uc001hkz.1_Missense_Mutation_p.I269L|ESRRG_uc010puc.1_Missense_Mutation_p.I308L|ESRRG_uc001hla.1_Missense_Mutation_p.I308L|ESRRG_uc001hlb.1_Missense_Mutation_p.I308L|ESRRG_uc010pud.1_Missense_Mutation_p.I139L|ESRRG_uc001hlc.1_Missense_Mutation_p.I308L|ESRRG_uc001hld.1_Missense_Mutation_p.I308L|ESRRG_uc001hkx.1_Missense_Mutation_p.I343L|ESRRG_uc009xdo.1_Missense_Mutation_p.I308L|ESRRG_uc001hle.1_Missense_Mutation_p.I308L	NM_001438	NP_001429	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 1	331					positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|kidney(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	TCGTCCATTATATAATCGTCT	0.418000													5	67					0	0	0.014758	0	0	
ARID4B	51742	broad.mit.edu	37	1	235403717	235403717	+	Missense_Mutation	SNP	T	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr1:235403717T>A	uc001hwq.2	-	8	994	c.496A>T	c.(496-498)AGG>TGG	p.R166W	ARID4B_uc001hwr.2_Missense_Mutation_p.R166W|ARID4B_uc001hws.3_Missense_Mutation_p.R166W|ARID4B_uc001hwu.1_Missense_Mutation_p.R166W|ARID4B_uc001hwt.3_5'UTR	NM_016374	NP_057458	Q4LE39	ARI4B_HUMAN	AT rich interactive domain 4B isoform 1	166					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|protein binding			ovary(2)|lung(1)	3	Ovarian(103;0.0473)|Breast(184;0.23)	all_cancers(173;0.000782)|Prostate(94;0.0132)|all_epithelial(177;0.0808)|Lung SC(1967;0.24)	OV - Ovarian serous cystadenocarcinoma(106;2.86e-05)			ATCTGTTTCCTATCATCCTCA	0.368000													9	36					0	0	0.047766	0	0	
WDR64	128025	broad.mit.edu	37	1	241912907	241912907	+	Silent	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr1:241912907G>A	uc001hzf.1	+	8	936	c.783G>A	c.(781-783)GGG>GGA	p.G261G	WDR64_uc001hzg.1_Silent_p.G7G	NM_144625	NP_653226	B1ANS9	WDR64_HUMAN	WD repeat domain 64	541										skin(1)	1	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			TGCCGGAGGGGAAAGACTGGA	0.522000													15	75					0	0	0.119110	0	0	
PCDH15	65217	broad.mit.edu	37	10	55581798	55581798	+	Silent	SNP	T	G	G			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr10:55581798T>G	uc001jju.1	-	33	6083	c.5688A>C	c.(5686-5688)GTA>GTC	p.V1896V	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qhs.1_Intron|PCDH15_uc010qht.1_Intron|PCDH15_uc010qhu.1_Intron|PCDH15_uc001jjv.1_Silent_p.V750V|PCDH15_uc010qhv.1_Silent_p.V1893V|PCDH15_uc010qhw.1_Silent_p.V1856V|PCDH15_uc010qhx.1_Silent_p.V1827V|PCDH15_uc010qhy.1_Silent_p.V1903V|PCDH15_uc010qhz.1_Silent_p.V1898V|PCDH15_uc010qia.1_Silent_p.V1876V|PCDH15_uc010qib.1_Silent_p.V1873V	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1896	Cytoplasmic (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				ACATGTTAGCTACTGATTTTT	0.368000										HNSCC(58;0.16)			28	153					0	0	0.108266	0	0	
PCDH15	65217	broad.mit.edu	37	10	55581808	55581808	+	Missense_Mutation	SNP	T	C	C			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr10:55581808T>C	uc001jju.1	-	33	6073	c.5678A>G	c.(5677-5679)GAA>GGA	p.E1893G	PCDH15_uc010qhq.1_Intron|PCDH15_uc010qhr.1_Intron|PCDH15_uc010qhs.1_Intron|PCDH15_uc010qht.1_Intron|PCDH15_uc010qhu.1_Intron|PCDH15_uc001jjv.1_Missense_Mutation_p.E747G|PCDH15_uc010qhv.1_Missense_Mutation_p.E1890G|PCDH15_uc010qhw.1_Missense_Mutation_p.E1853G|PCDH15_uc010qhx.1_Missense_Mutation_p.E1824G|PCDH15_uc010qhy.1_Missense_Mutation_p.E1900G|PCDH15_uc010qhz.1_Missense_Mutation_p.E1895G|PCDH15_uc010qia.1_Missense_Mutation_p.E1873G|PCDH15_uc010qib.1_Missense_Mutation_p.E1870G	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	1893	Cytoplasmic (Potential).				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				TACTGATTTTTCAAGTTCTGC	0.373000										HNSCC(58;0.16)			26	164					0	0	0.099896	0	0	
ANK3	288	broad.mit.edu	37	10	61894095	61894095	+	Missense_Mutation	SNP	C	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr10:61894095C>A	uc001jky.2	-	25	2967	c.2775G>T	c.(2773-2775)TTG>TTT	p.L925F	ANK3_uc001jkw.2_Missense_Mutation_p.L59F|ANK3_uc009xpa.2_Missense_Mutation_p.L59F|ANK3_uc001jkx.2_Missense_Mutation_p.L103F|ANK3_uc010qih.1_Missense_Mutation_p.L926F|ANK3_uc001jkz.3_Missense_Mutation_p.L919F|ANK3_uc001jla.1_5'UTR|ANK3_uc001jlb.1_Missense_Mutation_p.L432F	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	925					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						AGCTTCTGTTCAAGGTGTAAG	0.403000													10	35					1.58986e-06	1.711e-06	0.069234	1	0	
TET1	80312	broad.mit.edu	37	10	70450738	70450738	+	Missense_Mutation	SNP	G	C	C			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr10:70450738G>C	uc001jok.3	+	12	6083	c.5578G>C	c.(5578-5580)GCT>CCT	p.A1860P		NM_030625	NP_085128	Q8NFU7	TET1_HUMAN	CXXC finger 6	1860					DNA demethylation|inner cell mass cell differentiation|negative regulation of methylation-dependent chromatin silencing|stem cell maintenance		iron ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|structure-specific DNA binding|zinc ion binding			ovary(5)|lung(2)|prostate(1)|breast(1)	9						AGCCACACCAGCTCCACTGAA	0.542000													30	76					0	0	0.144211	0	0	
HELLS	3070	broad.mit.edu	37	10	96354483	96354483	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr10:96354483G>A	uc001kjt.2	+	19	2225	c.2120G>A	c.(2119-2121)AGA>AAA	p.R707K	HELLS_uc001kjs.2_Missense_Mutation_p.R691K|HELLS_uc009xul.2_Missense_Mutation_p.R609K|HELLS_uc009xum.2_Missense_Mutation_p.R577K|HELLS_uc009xun.2_Missense_Mutation_p.R583K|HELLS_uc009xuo.2_Missense_Mutation_p.R753K|HELLS_uc001kju.2_Missense_Mutation_p.R346K|HELLS_uc009xup.2_RNA|HELLS_uc009xuq.2_Missense_Mutation_p.R569K|HELLS_uc009xur.2_RNA	NM_018063	NP_060533	Q9NRZ9	HELLS_HUMAN	helicase, lymphoid-specific	707	Helicase C-terminal.				cell division|centromeric heterochromatin formation|lymphocyte proliferation|maintenance of DNA methylation|methylation-dependent chromatin silencing|mitosis|transcription, DNA-dependent	centromeric heterochromatin|nucleus	ATP binding|DNA binding|helicase activity			ovary(1)|kidney(1)	2		Colorectal(252;0.0429)		all cancers(201;2.13e-05)		GCCCAGGATAGATGTCATAGA	0.358000													32	35					0	0	0.069456	0	0	
DHDPSL	112817	broad.mit.edu	37	10	99371384	99371384	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr10:99371384C>T	uc001kny.2	+	7	1311	c.952C>T	c.(952-954)CGC>TGC	p.R318C	DHDPSL_uc001knz.2_Missense_Mutation_p.R155C|PI4K2A_uc010qoy.1_Intron	NM_138413	NP_612422	Q86XE5	HOGA1_HUMAN	DHDPS-like protein isoform 1	318					glyoxylate catabolic process	mitochondrion	4-hydroxy-2-oxoglutarate aldolase activity				0						GGAGGCACTGCGCATGGATTT	0.632000													5	22					0	0	0.014758	0	0	
OR6A2	8590	broad.mit.edu	37	11	6816802	6816802	+	Silent	SNP	G	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr11:6816802G>T	uc001mes.1	-	1	338	c.138C>A	c.(136-138)ATC>ATA	p.I46I		NM_003696	NP_003687	O95222	OR6A2_HUMAN	olfactory receptor, family 6, subfamily A,	46	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|central_nervous_system(1)|pancreas(1)	5		Medulloblastoma(188;0.0523)|all_neural(188;0.236)		Epithelial(150;4.78e-08)|BRCA - Breast invasive adenocarcinoma(625;0.129)		TTGCCATAATGATGAGTGTGT	0.458000													26	99					2.65835e-16	3.12909e-16	0.125774	1	0	
HIPK3	10114	broad.mit.edu	37	11	33375082	33375082	+	Missense_Mutation	SNP	C	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr11:33375082C>A	uc001mul.1	+	17	3886	c.3616C>A	c.(3616-3618)CCA>ACA	p.P1206T	HIPK3_uc001mum.1_Missense_Mutation_p.P1185T|HIPK3_uc009yjv.1_Missense_Mutation_p.P1185T	NM_005734	NP_005725	Q9H422	HIPK3_HUMAN	homeodomain interacting protein kinase 3 isoform	1206					anti-apoptosis|apoptosis|negative regulation of JUN kinase activity|peptidyl-serine phosphorylation|peptidyl-threonine phosphorylation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm	ATP binding|protein serine/threonine kinase activity			large_intestine(1)|skin(1)|stomach(1)|ovary(1)|pancreas(1)	5						TCCACTGAGTCCAACAAAACT	0.363000													8	82					0.000157383	0.000162414	0.038147	1	0	
F2	2147	broad.mit.edu	37	11	46750965	46750965	+	Missense_Mutation	SNP	G	C	C			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr11:46750965G>C	uc001ndf.3	+	12	1551	c.1508G>C	c.(1507-1509)GGC>GCC	p.G503A	F2_uc001ndg.3_RNA	NM_000506	NP_000497	P00734	THRB_HUMAN	coagulation factor II preproprotein	503	Peptidase S1.				activation of caspase activity|acute-phase response|blood coagulation, intrinsic pathway|cell surface receptor linked signaling pathway|cytosolic calcium ion homeostasis|fibrinolysis|leukocyte migration|negative regulation of astrocyte differentiation|negative regulation of fibrinolysis|negative regulation of platelet activation|negative regulation of proteolysis|peptidyl-glutamic acid carboxylation|platelet activation|positive regulation of collagen biosynthetic process|positive regulation of protein phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of release of sequestered calcium ion into cytosol|post-translational protein modification|proteolysis|STAT protein import into nucleus|tyrosine phosphorylation of STAT protein	cytosol|endoplasmic reticulum lumen|extracellular space|Golgi lumen|plasma membrane|soluble fraction	calcium ion binding|growth factor activity|serine-type endopeptidase activity|thrombospondin receptor activity			ovary(3)	3		all_lung(304;0.000414)|Lung NSC(402;0.0011)		BRCA - Breast invasive adenocarcinoma(625;0.146)	Antihemophilic Factor(DB00025)|Argatroban(DB00278)|Bivalirudin(DB00006)|Coagulation Factor IX(DB00100)|Drotrecogin alfa(DB00055)|Enoxaparin(DB01225)|Heparin(DB01109)|Lepirudin(DB00001)|Menadione(DB00170)|Proflavine(DB01123)|Simvastatin(DB00641)|Suramin(DB04786)|Warfarin(DB00682)|Ximelagatran(DB04898)	CGGGTGACAGGCTGGGGCAAC	0.647000													20	75					0	0	0.083992	0	0	
LRP4	4038	broad.mit.edu	37	11	46912013	46912013	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr11:46912013G>A	uc001ndn.3	-	14	1876	c.1730C>T	c.(1729-1731)CCC>CTC	p.P577L		NM_002334	NP_002325	O75096	LRP4_HUMAN	low density lipoprotein receptor-related protein	577	Extracellular (Potential).|LDL-receptor class B 3.				endocytosis|negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	integral to membrane	calcium ion binding|receptor activity			skin(2)|upper_aerodigestive_tract(1)|ovary(1)	4				Lung(87;0.159)		CTCAATACGGGGGGTGTTGCC	0.537000											OREG0020948	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	38					0	0	0.038147	0	0	
TNKS1BP1	85456	broad.mit.edu	37	11	57080878	57080878	+	Silent	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr11:57080878G>A	uc001njr.2	-	4	1596	c.1284C>T	c.(1282-1284)TTC>TTT	p.F428F	TNKS1BP1_uc001njs.2_Silent_p.F428F|TNKS1BP1_uc009ymd.1_5'UTR	NM_033396	NP_203754	Q9C0C2	TB182_HUMAN	tankyrase 1-binding protein 1	428	Pro-rich.|Acidic.				nuclear-transcribed mRNA poly(A) tail shortening|telomere maintenance via telomerase	cytoskeleton|cytosol|nuclear telomeric heterochromatin	ankyrin binding|enzyme binding			skin(1)	1		all_epithelial(135;0.21)				CACCTTCAGAGAATCGGCGCT	0.657000													9	40					0	0	0.047766	0	0	
IGHMBP2	3508	broad.mit.edu	37	11	68679026	68679026	+	Silent	SNP	G	C	C			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr11:68679026G>C	uc001ook.1	+	5	768	c.666G>C	c.(664-666)ACG>ACC	p.T222T	IGHMBP2_uc001ooj.1_RNA	NM_002180	NP_002171	P38935	SMBP2_HUMAN	immunoglobulin mu binding protein 2	222					cell death|DNA recombination|DNA repair|DNA replication|protein homooligomerization|transcription, DNA-dependent|translation	axon|growth cone|nucleus|ribonucleoprotein complex	ATP binding|ATP-dependent 5'-3' DNA helicase activity|ATP-dependent 5'-3' RNA helicase activity|ribosome binding|single-stranded DNA binding|transcription factor binding|tRNA binding|zinc ion binding				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GGAAAACCACGACTGTGGTTG	0.527000													13	64					0	0	0.093190	0	0	
C11orf30	56946	broad.mit.edu	37	11	76255390	76255390	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr11:76255390C>T	uc001oxl.2	+	19	2940	c.2797C>T	c.(2797-2799)CCT>TCT	p.P933S	C11orf30_uc001oxm.2_Missense_Mutation_p.P835S|C11orf30_uc010rsb.1_Missense_Mutation_p.P948S|C11orf30_uc010rsc.1_Missense_Mutation_p.P934S|C11orf30_uc001oxn.2_Missense_Mutation_p.P934S|C11orf30_uc010rsd.1_Missense_Mutation_p.P842S|C11orf30_uc001oxo.1_Missense_Mutation_p.P287S|C11orf30_uc010rse.1_Missense_Mutation_p.P180S|C11orf30_uc001oxp.2_Missense_Mutation_p.P33S	NM_020193	NP_064578	Q7Z589	EMSY_HUMAN	EMSY protein	933					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6						CACTTTAGACCCTCAGACAGG	0.493000													26	68					0	0	0.099896	0	0	
FAT3	120114	broad.mit.edu	37	11	92087849	92087849	+	Missense_Mutation	SNP	C	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr11:92087849C>A	uc001pdj.3	+	1	2588	c.2571C>A	c.(2569-2571)GAC>GAA	p.D857E		NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	857	Cadherin 8.|Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				AAGCCAGAGACAAAGACTTAG	0.398000										TCGA Ovarian(4;0.039)			19	45					3.32936e-07	3.63495e-07	0.175082	1	0	
CNTN5	53942	broad.mit.edu	37	11	99690317	99690317	+	Missense_Mutation	SNP	C	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr11:99690317C>A	uc001pga.2	+	4	437	c.98C>A	c.(97-99)GCT>GAT	p.A33D	CNTN5_uc009ywv.1_Missense_Mutation_p.A33D|CNTN5_uc001pfz.2_Missense_Mutation_p.A33D|CNTN5_uc001pgb.2_Intron	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	33					cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		TCATATGCTGCTTTGTTAAGA	0.348000													8	90					3.09899e-07	3.39986e-07	0.047766	1	0	
GRIA4	2893	broad.mit.edu	37	11	105850358	105850358	+	Silent	SNP	G	C	C			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr11:105850358G>C	uc001pix.2	+	17	3047	c.2601G>C	c.(2599-2601)GTG>GTC	p.V867V	GRIA4_uc001piw.2_3'UTR|GRIA4_uc009yxl.1_RNA	NM_000829	NP_000820	P48058	GRIA4_HUMAN	glutamate receptor, ionotrophic, AMPA 4 isoform	867	Cytoplasmic (Potential).				glutamate signaling pathway|synaptic transmission	cell junction|endocytic vesicle membrane|integral to membrane|postsynaptic membrane	alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity|extracellular-glutamate-gated ion channel activity			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8		Melanoma(852;0.000902)|Acute lymphoblastic leukemia(157;0.000994)|all_hematologic(158;0.0017)|Breast(348;0.0323)		BRCA - Breast invasive adenocarcinoma(274;0.000147)|Epithelial(105;0.0291)|all cancers(92;0.0899)	L-Glutamic Acid(DB00142)	CTGGGAGTGTGGGAGAGAATG	0.507000													22	71					0	0	0.069288	0	0	
CUL5	8065	broad.mit.edu	37	11	107965145	107965145	+	Missense_Mutation	SNP	A	G	G			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr11:107965145A>G	uc001pjv.2	+	14	2138	c.1471A>G	c.(1471-1473)AAC>GAC	p.N491D	CUL5_uc001pju.2_RNA	NM_003478	NP_003469	Q93034	CUL5_HUMAN	Vasopressin-activated calcium-mobilizing	491					cell cycle arrest|cell proliferation|G1/S transition of mitotic cell cycle|induction of apoptosis by intracellular signals|interspecies interaction between organisms|negative regulation of cell proliferation|ubiquitin-dependent protein catabolic process|viral reproduction	cullin-RING ubiquitin ligase complex|cytosol	calcium channel activity|receptor activity|ubiquitin protein ligase binding			ovary(1)	1		all_cancers(61;7.09e-10)|all_epithelial(67;2.97e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|Melanoma(852;4.48e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		BRCA - Breast invasive adenocarcinoma(274;3.58e-05)|Epithelial(105;4.68e-05)|all cancers(92;0.00122)|OV - Ovarian serous cystadenocarcinoma(223;0.217)		GGATTATGTAAACAAGCTTGC	0.299000													17	54					0	0	0.160694	0	0	
BUD13	84811	broad.mit.edu	37	11	116619288	116619288	+	Silent	SNP	G	C	C			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr11:116619288G>C	uc001ppn.2	-	10	1804	c.1770C>G	c.(1768-1770)TCC>TCG	p.S590S	BUD13_uc001ppo.2_Silent_p.S456S	NM_032725	NP_116114	Q9BRD0	BUD13_HUMAN	BUD13 homolog isoform 1	590										large_intestine(1)|pancreas(1)	2	all_hematologic(175;0.0487)	all_cancers(61;1.72e-06)|all_epithelial(67;0.000735)|Melanoma(852;0.022)|Acute lymphoblastic leukemia(157;0.0255)|Medulloblastoma(222;0.0523)|Breast(348;0.056)|all_hematologic(158;0.0588)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|Epithelial(105;5.81e-06)|all cancers(92;0.000144)|OV - Ovarian serous cystadenocarcinoma(223;0.154)		CAAATCCATTGGATCTGCAAT	0.433000													18	50					0	0	0.049695	0	0	
ARHGEF12	23365	broad.mit.edu	37	11	120352120	120352120	+	Silent	SNP	C	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr11:120352120C>A	uc001pxl.1	+	39	4396	c.4389C>A	c.(4387-4389)TCC>TCA	p.S1463S	ARHGEF12_uc009zau.1_Silent_p.S1360S	NM_015313	NP_056128	Q9NZN5	ARHGC_HUMAN	Rho guanine nucleotide exchange factor (GEF) 12	1463					apoptosis|axon guidance|G-protein coupled receptor protein signaling pathway|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|membrane	G-protein-coupled receptor binding|GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			lung(2)|breast(2)|skin(2)|ovary(1)	7		Breast(109;0.000813)|Medulloblastoma(222;0.0425)|Hepatocellular(160;0.0831)|all_hematologic(192;0.107)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(223;0.231)		ATACTCACTCCGATGGGGCAA	0.537000			T	MLL	AML								26	64					7.92952e-12	9.09681e-12	0.091800	1	0	
OR8B3	390271	broad.mit.edu	37	11	124266663	124266663	+	Silent	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr11:124266663G>A	uc010saj.1	-	1	585	c.585C>T	c.(583-585)AAC>AAT	p.N195N	OR8B2_uc001qab.3_Intron	NM_001005467	NP_001005467	Q8NGG8	OR8B3_HUMAN	olfactory receptor, family 8, subfamily B,	195	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2		Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0277)		CAACCACCTCGTTGACATAGG	0.428000													28	101					0	0	0.144211	0	0	
GLB1L2	89944	broad.mit.edu	37	11	134238567	134238567	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr11:134238567G>A	uc001qhp.2	+	10	1107	c.919G>A	c.(919-921)GAC>AAC	p.D307N	GLB1L2_uc009zdg.1_RNA	NM_138342	NP_612351	Q8IW92	GLBL2_HUMAN	galactosidase, beta 1-like 2 precursor	307					carbohydrate metabolic process	extracellular region	cation binding|hydrolase activity, hydrolyzing O-glycosyl compounds			ovary(1)|pancreas(1)|skin(1)	3	all_hematologic(175;0.127)	all_cancers(12;2.85e-18)|all_epithelial(12;1.21e-12)|all_lung(97;0.000276)|Lung NSC(97;0.000518)|Breast(109;0.00122)|Medulloblastoma(222;0.0399)|all_neural(223;0.0412)|Esophageal squamous(93;0.0844)		Epithelial(10;1.37e-11)|all cancers(11;2.2e-10)|BRCA - Breast invasive adenocarcinoma(10;3.09e-10)|OV - Ovarian serous cystadenocarcinoma(99;0.000885)|Lung(977;0.223)		TGCCATTGTGGACGCCGGCTC	0.527000													15	74					0	0	0.119110	0	0	
KCNA5	3741	broad.mit.edu	37	12	5154411	5154411	+	Missense_Mutation	SNP	C	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr12:5154411C>A	uc001qni.2	+	1	1327	c.1098C>A	c.(1096-1098)TTC>TTA	p.F366L		NM_002234	NP_002225	P22460	KCNA5_HUMAN	potassium voltage-gated channel, shaker-related	366	Helical; Name=Segment S3; (Potential).					Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity			ovary(2)|breast(2)	4						TGGCCATCTTCCCCTACTTCA	0.622000													31	96					1.38854e-25	1.66037e-25	0.134883	1	0	
LOH12CR1	118426	broad.mit.edu	37	12	12588569	12588569	+	Missense_Mutation	SNP	G	C	C			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr12:12588569G>C	uc001ral.2	+	3	576	c.210G>C	c.(208-210)TTG>TTC	p.L70F	LOH12CR1_uc009zhu.2_Missense_Mutation_p.L22F	NM_058169	NP_477517	Q969J3	L12R1_HUMAN	LOH1CR12	70										ovary(1)	1		Prostate(47;0.0802)		BRCA - Breast invasive adenocarcinoma(232;0.0205)		AAGGGCTATTGAGTGGCCAGA	0.403000													8	56					0	0	0.038147	0	0	
GPRC5A	9052	broad.mit.edu	37	12	13061936	13061936	+	Silent	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr12:13061936C>T	uc001rba.2	+	2	1403	c.753C>T	c.(751-753)GCC>GCT	p.A251A	GPRC5A_uc001raz.2_Silent_p.A251A	NM_003979	NP_003970	Q8NFJ5	RAI3_HUMAN	G protein-coupled receptor, family C, group 5,	251	Helical; Name=7; (Potential).					cytoplasmic vesicle membrane|Golgi apparatus|integral to plasma membrane	G-protein coupled receptor activity				0		Prostate(47;0.141)		BRCA - Breast invasive adenocarcinoma(232;0.0708)	Tretinoin(DB00755)	CCTTGGCTGCCAATGGCTGGG	0.537000													13	72					0	0	0.093190	0	0	
CASC1	55259	broad.mit.edu	37	12	25263069	25263069	+	Missense_Mutation	SNP	C	T	T	rs150985883		TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr12:25263069C>T	uc001rgl.2	-	14	1949	c.1867G>A	c.(1867-1869)GTA>ATA	p.V623I	CASC1_uc001rgk.2_Missense_Mutation_p.V629I|CASC1_uc001rgm.3_Missense_Mutation_p.V687I|CASC1_uc001rgj.2_Missense_Mutation_p.V583I|CASC1_uc010sje.1_Missense_Mutation_p.V564I|CASC1_uc010sjf.1_Missense_Mutation_p.V511I	NM_001082973	NP_001076442	Q6TDU7	CASC1_HUMAN	cancer susceptibility candidate 1 isoform b	623										ovary(2)	2	Acute lymphoblastic leukemia(6;0.00112)|all_hematologic(7;0.00152)|Melanoma(3;0.0301)|Colorectal(261;0.11)		OV - Ovarian serous cystadenocarcinoma(3;7.42e-20)|Epithelial(3;7.58e-16)|all cancers(3;1.07e-13)			ACCTTAAATACGACTTTTGTA	0.373000													13	47					0	0	0.105934	0	0	
CPNE8	144402	broad.mit.edu	37	12	39047804	39047804	+	Silent	SNP	T	C	C			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr12:39047804T>C	uc001rls.1	-	20	1659	c.1575A>G	c.(1573-1575)AAA>AAG	p.K525K	CPNE8_uc001rlr.1_Silent_p.K184K	NM_153634	NP_705898	Q86YQ8	CPNE8_HUMAN	copine VIII	525										pancreas(1)	1	Esophageal squamous(101;0.187)	Lung NSC(34;0.137)|Melanoma(24;0.152)|all_lung(34;0.157)				CTAGGACATCTTTAGCCAATC	0.463000													9	48					0	0	0.047766	0	0	
CSRNP2	81566	broad.mit.edu	37	12	51470289	51470289	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr12:51470289C>T	uc001rxu.1	-	2	354	c.56G>A	c.(55-57)GGC>GAC	p.G19D		NM_030809	NP_110436	Q9H175	CSRN2_HUMAN	TGF-beta induced apoptosis protein 12	19					apoptosis|positive regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity				0						AACTGATGAGCCCACATCCAC	0.532000													17	101					0	0	0.160694	0	0	
KRT73	319101	broad.mit.edu	37	12	53009973	53009973	+	Missense_Mutation	SNP	T	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr12:53009973T>A	uc001sas.2	-	2	674	c.639A>T	c.(637-639)GAA>GAT	p.E213D		NM_175068	NP_778238	Q86Y46	K2C73_HUMAN	keratin 73	213	Coil 1B.|Rod.					keratin filament	structural molecule activity			large_intestine(2)|ovary(2)|skin(2)	6				BRCA - Breast invasive adenocarcinoma(357;0.189)		CCTCCACCACTTCGCGCACGC	0.622000													26	83					0	0	0.091800	0	0	
ESYT1	23344	broad.mit.edu	37	12	56525997	56525997	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr12:56525997C>T	uc001sjq.2	+	8	915	c.865C>T	c.(865-867)CTC>TTC	p.L289F	ESYT1_uc001sjr.2_Missense_Mutation_p.L289F	NM_015292	NP_056107	Q9BSJ8	ESYT1_HUMAN	extended synaptotagmin-like protein 1	289						integral to membrane				ovary(4)|skin(1)	5						ATTCAGCTCACTCTCTGACAC	0.507000													52	221					0	0	0.139131	0	0	
COQ10A	93058	broad.mit.edu	37	12	56664067	56664067	+	Missense_Mutation	SNP	G	A	A	rs148374703	by1000genomes	TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr12:56664067G>A	uc001sko.3	+	5	971	c.710G>A	c.(709-711)CGT>CAT	p.R237H	COQ10A_uc001skp.3_Missense_Mutation_p.R205H|COQ10A_uc001skq.3_Missense_Mutation_p.R220H	NM_144576	NP_653177	Q96MF6	CQ10A_HUMAN	coenzyme Q10 homolog A isoform a	237						mitochondrial inner membrane				ovary(1)	1						GCCATCCCCCGTGAACTGATG	0.507000													22	105					0	0	0.069288	0	0	
NAV3	89795	broad.mit.edu	37	12	78513117	78513117	+	Silent	SNP	T	C	C			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr12:78513117T>C	uc001syp.2	+	15	3314	c.3141T>C	c.(3139-3141)GAT>GAC	p.D1047D	NAV3_uc001syo.2_Silent_p.D1047D|NAV3_uc010sub.1_Silent_p.D547D|NAV3_uc009zsf.2_Silent_p.D55D	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1047	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity	p.D1047N(1)		large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						GCAGTGGAGATGAAGGGAAAA	0.478000										HNSCC(70;0.22)			27	117					0	0	0.091800	0	0	
UBE3B	89910	broad.mit.edu	37	12	109972568	109972568	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr12:109972568C>T	uc001top.2	+	28	3791	c.3188C>T	c.(3187-3189)ACG>ATG	p.T1063M	UBE3B_uc001toq.2_Missense_Mutation_p.T1063M|UBE3B_uc001tos.2_Missense_Mutation_p.T490M|UBE3B_uc001tot.2_Missense_Mutation_p.T181M|UBE3B_uc010sxp.1_3'UTR	NM_130466	NP_569733	Q7Z3V4	UBE3B_HUMAN	ubiquitin protein ligase E3B	1063	HECT.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			ovary(2)|lung(2)	4						AGCATGAACACGGGCTTTGAA	0.617000													7	60					0	0	0.038147	0	0	
GLTP	51228	broad.mit.edu	37	12	110318161	110318161	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr12:110318161G>A	uc001tpm.2	-	1	133	c.19C>T	c.(19-21)CAC>TAC	p.H7Y	GLTP_uc010sxt.1_RNA	NM_016433	NP_057517	Q9NZD2	GLTP_HUMAN	glycolipid transfer protein	7						cytoplasm	glycolipid binding|glycolipid transporter activity				0		Lung NSC(355;2.38e-06)|Breast(359;0.00354)|Myeloproliferative disorder(1001;0.0122)		BRCA - Breast invasive adenocarcinoma(302;0.0025)		TTCAGCAAGTGTTCGGCCAGC	0.483000													5	19					0	0	0.021553	0	0	
TCHP	84260	broad.mit.edu	37	12	110350867	110350867	+	Missense_Mutation	SNP	T	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr12:110350867T>A	uc001tpn.2	+	10	1277	c.1124T>A	c.(1123-1125)CTG>CAG	p.L375Q	TCHP_uc001tpo.1_RNA|TCHP_uc001tpp.2_Missense_Mutation_p.L375Q	NM_001143852	NP_001137324	Q9BT92	TCHP_HUMAN	trichoplein	375	Trichohyalin/plectin homology domain.|Glu-rich.|Interaction with keratin proteins.				apoptosis|negative regulation of cell growth	apical cortex|centrosome|keratin filament|mitochondrion|plasma membrane	protein binding			skin(1)	1						CGGGACAGACTGATGAGCGAG	0.607000													7	31					0	0	0.038147	0	0	
RPLP0	6175	broad.mit.edu	37	12	120635143	120635143	+	Silent	SNP	G	C	C			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr12:120635143G>C	uc001txp.2	-	7	1011	c.774C>G	c.(772-774)ACC>ACG	p.T258T	GCN1L1_uc001txo.2_5'Flank|RPLP0_uc001txq.2_Silent_p.T258T|RPLP0_uc001txr.2_Silent_p.T196T	NM_053275	NP_444505	P05388	RLA0_HUMAN	ribosomal protein P0	258					endocrine pancreas development|interspecies interaction between organisms|ribosome biogenesis|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleus	protein binding|RNA binding|structural constituent of ribosome			ovary(1)	1	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CAAGTGGGAAGGTGTAATCCG	0.498000													12	40					0	0	0.080935	0	0	
PCDH9	5101	broad.mit.edu	37	13	67800353	67800353	+	Silent	SNP	T	C	C			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr13:67800353T>C	uc001vik.2	-	2	2912	c.2220A>G	c.(2218-2220)AAA>AAG	p.K740K	PCDH9_uc001vil.2_Silent_p.K740K|PCDH9_uc010thl.1_Silent_p.K740K|PCDH9_uc001vin.3_Silent_p.K740K	NM_203487	NP_982354	Q9HC56	PCDH9_HUMAN	protocadherin 9 isoform 1 precursor	740	Extracellular (Potential).|Cadherin 7.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)|skin(1)	6		Hepatocellular(98;0.0906)|Breast(118;0.107)		GBM - Glioblastoma multiforme(99;0.00819)		TAGGTGCTGGTTTTTCTTCCA	0.423000													18	91					0	0	0.160694	0	0	
LMO7	4008	broad.mit.edu	37	13	76381790	76381790	+	Silent	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr13:76381790C>T	uc001vjv.2	+	7	1432	c.672C>T	c.(670-672)GAC>GAT	p.D224D	LMO7_uc010thv.1_Intron|LMO7_uc001vjt.1_Intron|LMO7_uc010thw.1_Intron|LMO7_uc001vjw.1_Silent_p.D130D	NM_015842	NP_056667	Q8WWI1	LMO7_HUMAN	LIM domain only 7 isoform 2	509						cytoplasm|nucleus|ubiquitin ligase complex	ubiquitin-protein ligase activity|zinc ion binding			large_intestine(2)|ovary(1)|prostate(1)|skin(1)	5		Breast(118;0.0992)		GBM - Glioblastoma multiforme(99;0.0109)		TGGATCCTGACTTAGAGAATG	0.463000													18	72					0	0	0.160694	0	0	
SLITRK6	84189	broad.mit.edu	37	13	86370408	86370408	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr13:86370408A>C	uc001vll.1	-	2	695	c.236T>G	c.(235-237)CTT>CGT	p.L79R	SLITRK6_uc010afe.1_5'Flank	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	79	Extracellular (Potential).					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		ATTTGTGTGAAGCATCGTCAA	0.373000													32	158					0	0	0.163468	0	0	
GPC5	2262	broad.mit.edu	37	13	93518574	93518574	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr13:93518574T>G	uc010tif.1	+	8	1967	c.1601T>G	c.(1600-1602)ATC>AGC	p.I534S		NM_004466	NP_004457	P78333	GPC5_HUMAN	glypican 5 precursor	534						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding			ovary(2)|skin(2)|upper_aerodigestive_tract(1)	5	all_cancers(3;1.43e-07)|all_neural(89;0.0804)|Medulloblastoma(90;0.163)	Lung NSC(4;0.00454)				GTAAAGCAAATCCATCAAACA	0.428000													19	96					0	0	0.043863	0	0	
NALCN	259232	broad.mit.edu	37	13	101717887	101717887	+	Silent	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr13:101717887C>T	uc001vox.1	-	40	4662	c.4473G>A	c.(4471-4473)AAG>AAA	p.K1491K		NM_052867	NP_443099	Q8IZF0	NALCN_HUMAN	voltage gated channel like 1	1491	Cytoplasmic (Potential).					integral to membrane	sodium channel activity|voltage-gated ion channel activity			ovary(8)|breast(4)|skin(2)|pancreas(1)|central_nervous_system(1)	16	all_neural(89;0.0438)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)					GCAGCAGGAACTTGACGCGGA	0.532000													20	57					0	0	0.055883	0	0	
CHD8	57680	broad.mit.edu	37	14	21862288	21862288	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr14:21862288C>T	uc001was.1	-	32	4923	c.4829G>A	c.(4828-4830)CGT>CAT	p.R1610H	CHD8_uc001war.1_Missense_Mutation_p.R1506H|SNORD9_uc001wat.1_5'Flank	NM_020920	NP_065971	Q9HCK8	CHD8_HUMAN	chromodomain helicase DNA binding protein 8	1889					ATP-dependent chromatin remodeling|canonical Wnt receptor signaling pathway|negative regulation of transcription, DNA-dependent|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase III promoter|transcription, DNA-dependent	MLL1 complex	ATP binding|beta-catenin binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity|methylated histone residue binding|p53 binding			ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|breast(1)|skin(1)	10	all_cancers(95;0.00121)		Epithelial(56;2.55e-06)|all cancers(55;1.73e-05)	GBM - Glioblastoma multiforme(265;0.00424)		CAATTCTATACGGTAGAGAGT	0.512000													17	56					0	0	0.160694	0	0	
NUBPL	80224	broad.mit.edu	37	14	32034253	32034253	+	Missense_Mutation	SNP	C	T	T	rs35433432		TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr14:32034253C>T	uc001wrk.3	+	3	345	c.290C>T	c.(289-291)TCG>TTG	p.S97L	NUBPL_uc010amj.2_RNA	NM_025152	NP_079428	Q8TB37	NUBPL_HUMAN	nucleotide binding protein-like	97					mitochondrial respiratory chain complex I assembly|mitochondrion morphogenesis	mitochondrion	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding				0	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.214)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0677)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0102)		GCGAACGATTCGGTAGGTGtt	0.244000													18	51					0	0	0.043863	0	0	
SRP54	6729	broad.mit.edu	37	14	35483028	35483028	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr14:35483028C>T	uc001wso.2	+	10	1157	c.806C>T	c.(805-807)CCG>CTG	p.P269L	SRP54_uc010tpp.1_Missense_Mutation_p.P220L|SRP54_uc010tpq.1_Missense_Mutation_p.P205L	NM_003136	NP_003127	P61011	SRP54_HUMAN	signal recognition particle 54kDa isoform 1	269	G-domain.				GTP catabolic process|response to drug|SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition|SRP-dependent cotranslational protein targeting to membrane, translocation	cytosol|nuclear speck|signal recognition particle, endoplasmic reticulum targeting	7S RNA binding|drug binding|endoplasmic reticulum signal peptide binding|GDP binding|GTP binding|nucleoside-triphosphatase activity|ribonucleoprotein binding			ovary(1)	1	Breast(36;0.0545)|Hepatocellular(127;0.158)		LUAD - Lung adenocarcinoma(48;2.48e-05)|Lung(238;3.13e-05)|Epithelial(34;0.0314)|all cancers(34;0.0797)|BRCA - Breast invasive adenocarcinoma(188;0.243)	GBM - Glioblastoma multiforme(112;0.0396)		ACAAAAAGTCCGATTATTTTC	0.368000													17	81					0	0	0.160694	0	0	
SPTB	6710	broad.mit.edu	37	14	65251009	65251009	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr14:65251009C>T	uc001xht.2	-	18	4012	c.3958G>A	c.(3958-3960)GCA>ACA	p.A1320T	SPTB_uc001xhr.2_Missense_Mutation_p.A1320T|SPTB_uc001xhs.2_Missense_Mutation_p.A1320T|SPTB_uc001xhu.2_Missense_Mutation_p.A1320T|SPTB_uc010aqi.2_5'Flank	NM_000347	NP_000338	P11277	SPTB1_HUMAN	spectrin beta isoform b	1320	Spectrin 10.				actin filament capping|axon guidance	cell surface|cytosol|intrinsic to internal side of plasma membrane|protein complex|spectrin|spectrin-associated cytoskeleton	actin filament binding|structural constituent of cytoskeleton			ovary(7)|skin(2)|lung(1)|central_nervous_system(1)	11		all_lung(585;4.15e-09)		all cancers(60;4.33e-34)|OV - Ovarian serous cystadenocarcinoma(108;8.32e-20)|BRCA - Breast invasive adenocarcinoma(234;0.0628)		GCCAGCTCTGCCACAAACGCC	0.522000													25	76					0	0	0.076483	0	0	
OR4N3P	390539	broad.mit.edu	37	15	22413849	22413849	+	Missense_Mutation	SNP	C	G	G			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr15:22413849C>G	uc001yuf.2	+	1	148	c.148C>G	c.(148-150)CTG>GTG	p.L50V		NM_001080841	NP_001074310			RecName: Full=Olfactory receptor 4N2; AltName: Full=Olfactory receptor OR14-8; AltName: Full=Olfactory receptor OR14-13;												0						CTGCCTGCCTCTGCAGTATTC	0.502000													15	271					0	0	0.146539	0	0	
OCA2	4948	broad.mit.edu	37	15	28260028	28260028	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr15:28260028G>A	uc001zbh.3	-	9	1048	c.938C>T	c.(937-939)GCT>GTT	p.A313V	OCA2_uc010ayv.2_Missense_Mutation_p.A313V	NM_000275	NP_000266	Q04671	P_HUMAN	oculocutaneous albinism II	313	Extracellular (Potential).				eye pigment biosynthetic process	endoplasmic reticulum membrane|endosome membrane|integral to membrane|lysosomal membrane|melanosome membrane	arsenite transmembrane transporter activity|citrate transmembrane transporter activity|L-tyrosine transmembrane transporter activity|protein binding			ovary(3)|breast(1)|pancreas(1)	5		all_lung(180;2.93e-12)|Breast(32;0.000315)|Colorectal(260;0.234)		all cancers(64;5.03e-07)|Epithelial(43;2.13e-06)|BRCA - Breast invasive adenocarcinoma(123;0.045)		AAGAGGGACAGCCTGGGTCTG	0.577000									Oculocutaneous_Albinism				8	30					0	0	0.047766	0	0	
TJP1	7082	broad.mit.edu	37	15	30019161	30019161	+	Missense_Mutation	SNP	G	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr15:30019161G>T	uc001zcr.2	-	17	2610	c.2135C>A	c.(2134-2136)GCA>GAA	p.A712E	TJP1_uc010azl.2_Missense_Mutation_p.A700E|TJP1_uc001zcq.2_Missense_Mutation_p.A716E|TJP1_uc001zcs.2_Missense_Mutation_p.A712E	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	712	Guanylate kinase-like.				cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		ACGATCAACTGCATTTGGTGT	0.328000													23	112					6.36457e-07	6.88227e-07	0.091800	1	0	
FBN1	2200	broad.mit.edu	37	15	48829849	48829849	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr15:48829849C>T	uc001zwx.1	-	7	1023	c.695G>A	c.(694-696)CGC>CAC	p.R232H		NM_000138	NP_000129	P35555	FBN1_HUMAN	fibrillin 1 precursor	232	TB 1.				heart development|negative regulation of BMP signaling pathway by extracellular sequestering of BMP|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|skeletal system development	basement membrane|extracellular space|microfibril	calcium ion binding|extracellular matrix structural constituent|protein binding			ovary(2)|large_intestine(1)	3		all_lung(180;0.00279)		all cancers(107;4.24e-07)|GBM - Glioblastoma multiforme(94;1.41e-05)		GAAGCCACGGCGGCAGGGGTG	0.552000													19	95					0	0	0.043863	0	0	
GABPB1	2553	broad.mit.edu	37	15	50570977	50570977	+	Missense_Mutation	SNP	C	G	G			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr15:50570977C>G	uc001zyb.2	-	9	1464	c.1040G>C	c.(1039-1041)AGA>ACA	p.R347T	GABPB1_uc001zya.2_Missense_Mutation_p.R335T|GABPB1_uc010ufg.1_Missense_Mutation_p.R271T	NM_005254	NP_005245	Q06547	GABP1_HUMAN	GA binding protein transcription factor, beta	347					positive regulation of transcription from RNA polymerase II promoter	nucleus	protein binding|protein heterodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			large_intestine(1)	1						AAGAGCTTCTCTCTCCTAATT	0.338000													5	66					0	0	0.014758	0	0	
HERC1	8925	broad.mit.edu	37	15	63984726	63984726	+	Missense_Mutation	SNP	C	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr15:63984726C>A	uc002amp.2	-	31	5862	c.5714G>T	c.(5713-5715)GGG>GTG	p.G1905V		NM_003922	NP_003913	Q15751	HERC1_HUMAN	hect domain and RCC1-like domain 1	1905					protein modification process|transport	cytosol|Golgi apparatus|membrane	acid-amino acid ligase activity|ARF guanyl-nucleotide exchange factor activity			ovary(6)|breast(6)|lung(5)|central_nervous_system(2)	19						TAAAAAATCCCCTAGATGGAG	0.388000													12	28					6.40141e-05	6.63633e-05	0.080935	1	0	
SNUPN	10073	broad.mit.edu	37	15	75901916	75901916	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr15:75901916C>T	uc002ban.2	-	5	575	c.485G>A	c.(484-486)CGA>CAA	p.R162Q	SNUPN_uc002bao.2_Missense_Mutation_p.R162Q|SNUPN_uc002bap.2_Missense_Mutation_p.R204Q|SNUPN_uc002baq.2_Missense_Mutation_p.R162Q|SNUPN_uc002bar.2_Missense_Mutation_p.R162Q|SNUPN_uc002bas.2_Missense_Mutation_p.R162Q	NM_005701	NP_005692	O95149	SPN1_HUMAN	snurportin 1	162					ncRNA metabolic process|protein import into nucleus|spliceosomal snRNP assembly	cytosol|nuclear pore	protein transporter activity|RNA cap binding			pancreas(1)	1						TGTTGAGTTTCGCCTGTTGCC	0.403000													5	76					0	0	0.014758	0	0	
CCNF	899	broad.mit.edu	37	16	2482985	2482985	+	Silent	SNP	G	C	C			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr16:2482985G>C	uc002cqd.1	+	3	283	c.195G>C	c.(193-195)CTG>CTC	p.L65L	CCNF_uc002cqe.1_Intron	NM_001761	NP_001752	P41002	CCNF_HUMAN	cyclin F	65	F-box.				cell division|mitosis|negative regulation of centrosome duplication|protein ubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	centriole|nucleus|SCF ubiquitin ligase complex	protein binding			central_nervous_system(1)|kidney(1)	2		Ovarian(90;0.17)				TGAAGGACCTGGTGGACAACC	0.612000													4	17					0	0	0.014758	0	0	
SRRM2	23524	broad.mit.edu	37	16	2814071	2814071	+	Missense_Mutation	SNP	C	G	G			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr16:2814071C>G	uc002crk.2	+	11	4091	c.3542C>G	c.(3541-3543)CCT>CGT	p.P1181R	SRRM2_uc002crj.1_Missense_Mutation_p.P1085R|SRRM2_uc002crl.1_Missense_Mutation_p.P1181R|SRRM2_uc010bsu.1_Missense_Mutation_p.P1085R	NM_016333	NP_057417	Q9UQ35	SRRM2_HUMAN	splicing coactivator subunit SRm300	1181	Ser-rich.					Cajal body|catalytic step 2 spliceosome|nuclear speck	C2H2 zinc finger domain binding|protein N-terminus binding|RNA binding			ovary(1)|pancreas(1)|central_nervous_system(1)|skin(1)	4						GCATCACCTCCTAGACAGAAA	0.473000													8	159					0	0	0.038147	0	0	
KIAA0430	9665	broad.mit.edu	37	16	15719275	15719275	+	Missense_Mutation	SNP	G	C	C			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr16:15719275G>C	uc002ddr.2	-	8	2100	c.1907C>G	c.(1906-1908)GCA>GGA	p.A636G	KIAA0430_uc002ddq.2_Intron|KIAA0430_uc010uzv.1_Missense_Mutation_p.A632G|KIAA0430_uc010uzw.1_Missense_Mutation_p.A634G	NM_014647	NP_055462	Q9Y4F3	LKAP_HUMAN	limkain b1	635						peroxisome	nucleotide binding|RNA binding				0						TCCAGAATTTGCCTGTGACCC	0.373000													17	83					0	0	0.043863	0	0	
DNAH3	55567	broad.mit.edu	37	16	21108730	21108730	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr16:21108730G>A	uc010vbe.1	-	18	2611	c.2611C>T	c.(2611-2613)CAG>TAG	p.Q871*		NM_017539	NP_060009	Q8TD57	DYH3_HUMAN	dynein, axonemal, heavy chain 3	871	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(10)|skin(3)|large_intestine(2)|central_nervous_system(2)|upper_aerodigestive_tract(1)	18				GBM - Glioblastoma multiforme(48;0.207)		GACCACAGCTGCTCATAAGGT	0.483000													29	120					0	0	0.134883	0	0	
CDH1	999	broad.mit.edu	37	16	68847282	68847282	+	Missense_Mutation	SNP	G	C	C			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr16:68847282G>C	uc002ewg.1	+	9	1328	c.1204G>C	c.(1204-1206)GAT>CAT	p.D402H	CDH1_uc010vlj.1_RNA|CDH1_uc010cfg.1_Intron	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	402	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding	p.Y380_K440del(5)|p.D402N(2)		breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		GACTGATGCTGATGCCCCCAA	0.473000			Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer				14	170					0	0	0.105934	0	0	
GLG1	2734	broad.mit.edu	37	16	74524978	74524978	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr16:74524978C>T	uc002fcy.3	-	8	1420	c.1370G>A	c.(1369-1371)CGA>CAA	p.R457Q	GLG1_uc002fcx.2_Missense_Mutation_p.R457Q|GLG1_uc002fcw.3_Missense_Mutation_p.R446Q|GLG1_uc002fcz.3_Intron	NM_001145667	NP_001139139	Q92896	GSLG1_HUMAN	golgi apparatus protein 1 isoform 3	457	Extracellular (Potential).|Cys-rich GLG1 6.					Golgi membrane|integral to membrane	receptor binding			ovary(1)|breast(1)	2						CCGCCCTTTTCGATGTAATCC	0.507000													35	117					0	0	0.163468	0	0	
SCARF1	8578	broad.mit.edu	37	17	1538386	1538386	+	Missense_Mutation	SNP	G	T	T	rs144425748	byFrequency	TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr17:1538386G>T	uc002fsz.1	-	11	2209	c.2159C>A	c.(2158-2160)GCG>GAG	p.A720E	SCARF1_uc002fsy.1_3'UTR|SCARF1_uc002fta.1_RNA|SCARF1_uc010cjv.1_Missense_Mutation_p.A634E	NM_003693	NP_003684	Q14162	SREC_HUMAN	scavenger receptor class F, member 1 isoform 1	720	Gly-rich.|Cytoplasmic (Potential).				cell adhesion|neuron remodeling|positive regulation of axon regeneration|receptor-mediated endocytosis	integral to membrane	low-density lipoprotein particle binding|scavenger receptor activity			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.0822)		CTTGGCTTCCGCCTGGCCTTT	0.632000													15	40					2.23348e-06	2.39226e-06	0.146539	1	0	
ZZEF1	23140	broad.mit.edu	37	17	3920947	3920947	+	Silent	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr17:3920947G>A	uc002fxe.2	-	48	7783	c.7719C>T	c.(7717-7719)AGC>AGT	p.S2573S	ZZEF1_uc002fxg.1_5'Flank	NM_015113	NP_055928	O43149	ZZEF1_HUMAN	zinc finger, ZZ type with EF hand domain 1	2573							calcium ion binding|zinc ion binding			ovary(2)|central_nervous_system(1)|pancreas(1)	4						GCTGCAGTTCGCTCTCTGTGC	0.592000													19	74					0	0	0.043863	0	0	
ALOXE3	59344	broad.mit.edu	37	17	8012632	8012632	+	Silent	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr17:8012632G>A	uc010cnr.2	-	12	1792	c.1422C>T	c.(1420-1422)ATC>ATT	p.I474I	ALOXE3_uc002gka.2_Silent_p.I630I|ALOXE3_uc010vuo.1_Silent_p.I606I	NM_021628	NP_067641	Q9BYJ1	LOXE3_HUMAN	arachidonate lipoxygenase 3 isoform 2	474	Lipoxygenase.				leukotriene biosynthetic process		iron ion binding|lipoxygenase activity			skin(3)|lung(1)|central_nervous_system(1)	5						TCATGAGGTAGATGAGGCCTT	0.652000													12	28					0	0	0.093190	0	0	
COX10	1352	broad.mit.edu	37	17	14110524	14110524	+	Silent	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr17:14110524C>T	uc002gof.3	+	7	1530	c.1326C>T	c.(1324-1326)CCC>CCT	p.P442P	COX10_uc010vvs.1_Silent_p.P225P|COX10_uc010vvt.1_Silent_p.P250P	NM_001303	NP_001294	Q12887	COX10_HUMAN	heme A:farnesyltransferase precursor	442					heme a biosynthetic process|heme O biosynthetic process|respiratory chain complex IV assembly	integral to membrane|mitochondrial membrane	protoheme IX farnesyltransferase activity				0		all_lung(20;0.06)|Lung SC(565;0.168)		UCEC - Uterine corpus endometrioid carcinoma (92;0.106)		GGCCCCCTCCCAGCTGAGAGC	0.632000													15	16					0	0	0.146539	0	0	
FLCN	201163	broad.mit.edu	37	17	17119728	17119728	+	Silent	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr17:17119728C>T	uc002gra.3	-	11	1770	c.1266G>A	c.(1264-1266)CCG>CCA	p.P422P	PLD6_uc010cpn.2_RNA	NM_144997	NP_659434	Q8NFG4	FLCN_HUMAN	folliculin isoform 1	422					regulation of protein phosphorylation	cytoplasm|nucleus|plasma membrane	protein binding			thyroid(1)|haematopoietic_and_lymphoid_tissue(1)|lung(1)	3						TCTGCACGTGCGGGCTGAGCC	0.677000									Birt-Hogg-Dub__syndrome|Familial_Non-VHL_Clear_Cell_Renal_Cancer				3	22					0	0	0.115264	0	0	
MLLT6	4302	broad.mit.edu	37	17	36865461	36865461	+	Missense_Mutation	SNP	C	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr17:36865461C>A	uc002hqi.3	+	5	403	c.390C>A	c.(388-390)AGC>AGA	p.S130R	MLLT6_uc010wdr.1_Missense_Mutation_p.S130R|MLLT6_uc010cvm.1_Missense_Mutation_p.S130R	NM_005937	NP_005928	P55198	AF17_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	130	PHD-type 2.				regulation of transcription, DNA-dependent	nucleus	protein binding|zinc ion binding			breast(3)|prostate(1)|lung(1)|skin(1)	6	Breast(7;4.43e-21)					GCCGGGAGAGCAAGGCGGCCT	0.642000			T	MLL	AL								36	173					7.53189e-24	8.95899e-24	0.098360	1	0	
KRTAP4-7	100132476	broad.mit.edu	37	17	39240780	39240780	+	Missense_Mutation	SNP	A	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr17:39240780A>T	uc010wfn.1	+	1	322	c.322A>T	c.(322-324)ACC>TCC	p.T108S		NM_033061	NP_149050			keratin associated protein 4-7												0						ctgccagcccacctgctgccg	0.184000													8	13					0	0	0.038147	0	0	
STAT3	6774	broad.mit.edu	37	17	40476813	40476813	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr17:40476813C>T	uc002hzl.1	-	17	1756	c.1516G>A	c.(1516-1518)GAG>AAG	p.E506K	STAT3_uc002hzk.1_Missense_Mutation_p.E506K|STAT3_uc002hzm.1_Missense_Mutation_p.E506K|STAT3_uc010wgh.1_Missense_Mutation_p.E408K|STAT3_uc002hzn.1_Missense_Mutation_p.E506K	NM_139276	NP_644805	P40763	STAT3_HUMAN	signal transducer and activator of transcription	506					cellular component movement|eating behavior|eye photoreceptor cell differentiation|glucose homeostasis|interleukin-6-mediated signaling pathway|interspecies interaction between organisms|JAK-STAT cascade involved in growth hormone signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein import into nucleus|response to estradiol stimulus|sexual reproduction|temperature homeostasis	cytosol|nucleus|plasma membrane	calcium ion binding|ligand-regulated transcription factor activity|protein dimerization activity|protein kinase binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			ovary(1)|lung(1)|breast(1)|central_nervous_system(1)	4		all_cancers(22;1.39e-06)|all_epithelial(22;2.95e-05)|Breast(137;0.000135)		BRCA - Breast invasive adenocarcinoma(366;0.139)		CTCAGGACCTCGGCCACTTGA	0.502000									Hyperimmunoglobulin_E_Recurrent_Infection_Syndrome				5	73					0	0	0.029380	0	0	
PTRF	284119	broad.mit.edu	37	17	40557205	40557205	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr17:40557205C>T	uc002hzo.2	-	2	832	c.673G>A	c.(673-675)GGC>AGC	p.G225S	PTRF_uc010wgi.1_Missense_Mutation_p.G207S	NM_012232	NP_036364	Q6NZI2	PTRF_HUMAN	polymerase I and transcript release factor	225	Potential.				regulation of transcription, DNA-dependent|termination of RNA polymerase I transcription|transcription initiation from RNA polymerase I promoter	caveola|cytosol|endoplasmic reticulum|microsome|mitochondrion|nucleoplasm	protein binding|rRNA primary transcript binding			breast(1)	1		all_cancers(22;0.00146)|Breast(137;0.00116)|all_epithelial(22;0.0134)		BRCA - Breast invasive adenocarcinoma(366;0.193)		CGCCGCAGGCCGCTGCGCTTG	0.632000													29	132					0	0	0.125774	0	0	
DNAH17	8632	broad.mit.edu	37	17	76563093	76563093	+	Missense_Mutation	SNP	G	C	C			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr17:76563093G>C	uc002jvv.1	-	6	652	c.546C>G	c.(544-546)GAC>GAG	p.D182E						RecName: Full=Dynein heavy chain 17, axonemal; AltName: Full=Axonemal beta dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain 17; AltName: Full=Ciliary dynein heavy chain-like protein 1; AltName: Full=Axonemal dynein heavy chain-like protein 1; AltName: Full=Dynein light chain 2, axonemal;											ovary(6)|breast(2)|skin(1)	9			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			AGTCTCCAGGGTCCAAGGGAT	0.582000													5	18					0	0	0.021553	0	0	
OSBPL1A	114876	broad.mit.edu	37	18	21751427	21751427	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr18:21751427C>T	uc002kve.2	-	23	2411	c.2237G>A	c.(2236-2238)TGT>TAT	p.C746Y	OSBPL1A_uc002kvd.2_Missense_Mutation_p.C233Y|OSBPL1A_uc010xbc.1_Missense_Mutation_p.C364Y	NM_080597	NP_542164	Q9BXW6	OSBL1_HUMAN	oxysterol-binding protein-like 1A isoform B	746					cholesterol metabolic process|lipid transport|vesicle-mediated transport		phospholipid binding			ovary(4)	4	all_cancers(21;0.000396)|all_epithelial(16;4.36e-06)|Lung NSC(20;0.00171)|all_lung(20;0.0055)|Colorectal(14;0.0505)|Ovarian(20;0.17)					AAAAAGGCCACATGGCTTAAA	0.303000													9	126					0	0	0.058154	0	0	
DSC2	1824	broad.mit.edu	37	18	28651610	28651610	+	Missense_Mutation	SNP	C	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr18:28651610C>A	uc002kwl.3	-	13	2540	c.2086G>T	c.(2086-2088)GCC>TCC	p.A696S	DSC2_uc002kwk.3_Missense_Mutation_p.A696S	NM_024422	NP_077740	Q02487	DSC2_HUMAN	desmocollin 2 isoform Dsc2a preproprotein	696	Helical; (Potential).				homophilic cell adhesion	desmosome|integral to membrane	calcium ion binding			ovary(2)|skin(1)	3			OV - Ovarian serous cystadenocarcinoma(10;0.0241)			GCAAGGATGGCCCACTTTCCA	0.403000													14	48					1.05317e-09	1.1783e-09	0.119110	1	0	
ZNF397	84307	broad.mit.edu	37	18	32822695	32822695	+	Silent	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr18:32822695G>A	uc010dmp.2	+	2	417	c.261G>A	c.(259-261)GAG>GAA	p.E87E	ZNF397_uc002kyi.2_Silent_p.E87E|ZNF397_uc010dmq.2_Silent_p.E87E|ZNF397_uc010dmr.2_Intron|ZNF397_uc002kyj.2_Silent_p.E87E|ZNF397_uc002kyk.1_Silent_p.E87E	NM_001135178	NP_001128650	Q8NF99	ZN397_HUMAN	zinc finger protein 397 isoform 1	87	SCAN box.				viral reproduction	cytoplasm|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0						ACACAAAGGAGCAGATCTTAG	0.532000													23	53					0	0	0.069288	0	0	
DCC	1630	broad.mit.edu	37	18	50734058	50734058	+	Missense_Mutation	SNP	G	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr18:50734058G>T	uc002lfe.1	+	11	2319	c.1732G>T	c.(1732-1734)GTT>TTT	p.V578F	DCC_uc010xdr.1_Missense_Mutation_p.V426F|DCC_uc010dpf.1_Missense_Mutation_p.V233F	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	578	Extracellular (Potential).|Fibronectin type-III 2.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GAATATAGAGGTTGATGGACT	0.383000													15	83					1.49906e-05	1.56846e-05	0.119110	1	0	
STXBP2	6813	broad.mit.edu	37	19	7704638	7704638	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr19:7704638G>A	uc002mha.3	+	4	236	c.191G>A	c.(190-192)CGG>CAG	p.R64Q	STXBP2_uc002mhb.3_Missense_Mutation_p.R64Q|STXBP2_uc010dvj.2_RNA|STXBP2_uc010xjr.1_Missense_Mutation_p.R64Q|STXBP2_uc010dvk.2_Missense_Mutation_p.R32Q|STXBP2_uc002mhc.3_5'UTR|STXBP2_uc010dvl.1_5'Flank	NM_006949	NP_008880	Q15833	STXB2_HUMAN	syntaxin binding protein 2 isoform a	64					leukocyte mediated cytotoxicity|neutrophil degranulation|protein transport|regulation of mast cell degranulation|vesicle docking involved in exocytosis	azurophil granule|cytolytic granule|cytosol|specific granule|tertiary granule	syntaxin-3 binding			central_nervous_system(1)	1						ATCAACAAACGGCGGGAACCC	0.498000													6	19					0	0	0.047766	0	0	
OR7D2	162998	broad.mit.edu	37	19	9297113	9297113	+	Nonsense_Mutation	SNP	C	G	G			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr19:9297113C>G	uc002mkz.1	+	1	844	c.656C>G	c.(655-657)TCA>TGA	p.S219*		NM_175883	NP_787079	Q96RA2	OR7D2_HUMAN	olfactory receptor, family 7, subfamily D,	219	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent|sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|upper_aerodigestive_tract(1)	3						TTCTCTTATTCACGAATTGCT	0.458000													29	96					0	0	0.116897	0	0	
LDLR	3949	broad.mit.edu	37	19	11224398	11224398	+	Missense_Mutation	SNP	G	A	A	rs141673997	byFrequency	TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr19:11224398G>A	uc002mqk.3	+	10	1714	c.1546G>A	c.(1546-1548)GGC>AGC	p.G516S	LDLR_uc010xlk.1_Missense_Mutation_p.G516S|LDLR_uc010xll.1_Missense_Mutation_p.G475S|LDLR_uc010xlm.1_Missense_Mutation_p.G369S|LDLR_uc010xln.1_Missense_Mutation_p.G389S|LDLR_uc010xlo.1_Missense_Mutation_p.G348S	NM_000527	NP_000518	P01130	LDLR_HUMAN	low density lipoprotein receptor precursor	516	Extracellular (Potential).|LDL-receptor class B 3.				cholesterol homeostasis|cholesterol metabolic process|interspecies interaction between organisms|intestinal cholesterol absorption|low-density lipoprotein particle clearance|receptor-mediated endocytosis	clathrin-coated endocytic vesicle membrane|coated pit|early endosome|endosome membrane|external side of plasma membrane|integral to plasma membrane|low-density lipoprotein particle|lysosome	calcium ion binding|low-density lipoprotein receptor activity|protein binding|very-low-density lipoprotein particle receptor activity			ovary(2)|skin(2)	4		Lung NSC(9;0.000245)|Renal(1328;0.0007)|Hepatocellular(1079;0.0524)		GBM - Glioblastoma multiforme(1328;1.36e-05)|STAD - Stomach adenocarcinoma(1328;0.000766)|Lung(535;0.197)	Methyl aminolevulinate(DB00992)|Porfimer(DB00707)	CAGGGAGAACGGCTCCAAGCC	0.572000													14	49					0	0	0.132662	0	0	
NR2F6	2063	broad.mit.edu	37	19	17355924	17355924	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr19:17355924G>A	uc002nfq.2	-	1	228	c.106C>T	c.(106-108)CCC>TCC	p.P36S		NM_005234	NP_005225	P10588	NR2F6_HUMAN	nuclear receptor subfamily 2, group F, member 6	36					negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|thyroid hormone receptor activity|zinc ion binding				0						GCGGCACCGGGGGGCGAGGCC	0.771000													3	4					0	0	0.115264	0	0	
ZNF431	170959	broad.mit.edu	37	19	21365482	21365482	+	Missense_Mutation	SNP	T	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr19:21365482T>A	uc002npp.2	+	5	523	c.376T>A	c.(376-378)TTT>ATT	p.F126I	ZNF431_uc010ecq.2_Missense_Mutation_p.F35I|ZNF431_uc010ecr.2_Missense_Mutation_p.F127I	NM_133473	NP_597730	Q8TF32	ZN431_HUMAN	zinc finger protein 431	126					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(2)	2						AAAAGATTCTTTTCAACAAGT	0.338000													15	49					0	0	0.146539	0	0	
UBA2	10054	broad.mit.edu	37	19	34935939	34935939	+	Silent	SNP	A	C	C			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr19:34935939A>C	uc002nvk.2	+	8	754	c.684A>C	c.(682-684)GCA>GCC	p.A228A	UBA2_uc010xrx.1_Silent_p.A101A|UBA2_uc002nvl.2_Silent_p.A132A	NM_005499	NP_005490	Q9UBT2	SAE2_HUMAN	SUMO-1 activating enzyme subunit 2	228					protein sumoylation	nucleus	ATP binding|enzyme activator activity|ligase activity|metal ion binding|protein heterodimerization activity|SUMO activating enzyme activity			ovary(1)	1	Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.211)			GAGCTAGAGCATCTAATGAAG	0.358000													28	90					0	0	0.144211	0	0	
RYR1	6261	broad.mit.edu	37	19	38986957	38986957	+	Silent	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr19:38986957C>T	uc002oit.2	+	40	6781	c.6651C>T	c.(6649-6651)GGC>GGT	p.G2217G	RYR1_uc002oiu.2_Silent_p.G2217G|RYR1_uc002oiv.1_5'UTR	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	2217	Cytoplasmic.|6 X approximate repeats.				muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TCCTCGGGGGCGGCGAGTCCA	0.637000													7	91					0	0	0.029380	0	0	
PNMAL2	57469	broad.mit.edu	37	19	46998642	46998642	+	Silent	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr19:46998642C>T	uc002pes.2	-	1	528	c.81G>A	c.(79-81)CCG>CCA	p.P27P	uc002peu.1_3'UTR	NM_020709	NP_065760	Q9ULN7	PNML2_HUMAN	PNMA-like 2	27										central_nervous_system(1)	1		Ovarian(192;0.00965)|all_neural(266;0.0459)		OV - Ovarian serous cystadenocarcinoma(262;0.000322)|all cancers(93;0.00233)|GBM - Glioblastoma multiforme(486;0.0421)|Epithelial(262;0.0427)		ccaggccctccgggatgccgg	0.065000													6	71					0	0	0.021553	0	0	
SCAF1	58506	broad.mit.edu	37	19	50156700	50156700	+	Silent	SNP	A	C	C			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr19:50156700A>C	uc002poq.2	+	7	3178	c.3054A>C	c.(3052-3054)CGA>CGC	p.R1018R		NM_021228	NP_067051	Q9H7N4	SFR19_HUMAN	SR-related CTD-associated factor 1	1018	Glu-rich.				mRNA processing|RNA splicing	nucleus	RNA binding				0		all_lung(116;1.05e-05)|Lung NSC(112;3.77e-05)|all_neural(266;0.196)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.00113)|GBM - Glioblastoma multiforme(134;0.0204)		CTGGGGTCCGAGGTGGGGCgg	0.498000													5	10					0	0	0.021553	0	0	
ZNF415	55786	broad.mit.edu	37	19	53612111	53612111	+	Missense_Mutation	SNP	G	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr19:53612111G>T	uc002qax.2	-	7	1680	c.1331C>A	c.(1330-1332)ACT>AAT	p.T444N	ZNF415_uc002qat.2_Missense_Mutation_p.T408N|ZNF415_uc002qaw.2_Missense_Mutation_p.T396N|ZNF415_uc010yds.1_Missense_Mutation_p.T396N|ZNF415_uc010ydt.1_Missense_Mutation_p.T396N|ZNF415_uc002qau.2_Missense_Mutation_p.T383N|ZNF415_uc002qav.2_Missense_Mutation_p.T408N|ZNF415_uc002qba.2_Missense_Mutation_p.T166N|ZNF415_uc002qay.2_Missense_Mutation_p.T383N|ZNF415_uc002qaz.2_Missense_Mutation_p.T444N	NR_028343		Q09FC8	ZN415_HUMAN	RecName: Full=Zinc finger protein 415;	444	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton|nucleolus	DNA binding|zinc ion binding			ovary(1)	1				GBM - Glioblastoma multiforme(134;0.0191)		AAGGCTTGAAGTCTGACTGAA	0.413000													18	68					5.01169e-05	5.21955e-05	0.160694	1	0	
ZNF813	126017	broad.mit.edu	37	19	53994018	53994018	+	Missense_Mutation	SNP	C	G	G			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr19:53994018C>G	uc002qbu.2	+	4	660	c.532C>G	c.(532-534)CAA>GAA	p.Q178E	ZNF813_uc010eqq.1_Intron	NM_001004301	NP_001004301	Q6ZN06	ZN813_HUMAN	zinc finger protein 813	178					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			large_intestine(1)	1				GBM - Glioblastoma multiforme(134;0.00619)		TTCAACATCCCAAAGAATTTC	0.398000													36	175					0	0	0.069456	0	0	
MZF1	7593	broad.mit.edu	37	19	59073782	59073782	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr19:59073782C>T	uc002qto.2	-	6	2423	c.1862G>A	c.(1861-1863)GGC>GAC	p.G621D	LOC100131691_uc002qtm.2_Intron|MZF1_uc002qtn.2_Missense_Mutation_p.G621D	NM_198055	NP_932172	P28698	MZF1_HUMAN	zinc finger protein 42 isoform 2	621					viral reproduction	nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			ovary(1)	1		all_cancers(17;4.4e-22)|all_epithelial(17;2.15e-16)|Lung NSC(17;1.24e-06)|all_lung(17;5.41e-06)|Colorectal(82;3.46e-05)|Renal(17;0.00179)|all_neural(62;0.00607)|Ovarian(87;0.0443)|Breast(46;0.0928)|Medulloblastoma(540;0.184)		UCEC - Uterine corpus endometrioid carcinoma (67;0.0443)|all cancers(4;7.92e-14)|Epithelial(4;5.57e-11)|OV - Ovarian serous cystadenocarcinoma(4;1.13e-09)|GBM - Glioblastoma multiforme(193;0.0108)|Lung(386;0.182)		GGGCTTTTCGCCGGTGTGTGT	0.672000													3	7					0	0	0.150653	0	0	
WDR35	57539	broad.mit.edu	37	2	20166586	20166586	+	Missense_Mutation	SNP	T	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr2:20166586T>A	uc002rdi.2	-	10	1201	c.1093A>T	c.(1093-1095)AAC>TAC	p.N365Y	WDR35_uc002rdj.2_Missense_Mutation_p.N365Y|WDR35_uc010ext.2_RNA|WDR35_uc002rdh.2_5'UTR	NM_001006657	NP_001006658	Q9P2L0	WDR35_HUMAN	WD repeat domain 35 isoform 1	365										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TTTTCATTGTTTTTCGTATCC	0.368000													16	56					0	0	0.160694	0	0	
PUM2	23369	broad.mit.edu	37	2	20507793	20507793	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr2:20507793T>G	uc002rds.1	-	6	852	c.829A>C	c.(829-831)ACT>CCT	p.T277P	PUM2_uc002rdt.1_Missense_Mutation_p.T277P|PUM2_uc002rdr.2_Missense_Mutation_p.T216P|PUM2_uc010yjy.1_Missense_Mutation_p.T277P|PUM2_uc002rdu.1_Missense_Mutation_p.T277P|PUM2_uc010yjz.1_Missense_Mutation_p.T216P	NM_015317	NP_056132	Q8TB72	PUM2_HUMAN	pumilio homolog 2	277					regulation of translation	perinuclear region of cytoplasm|stress granule	protein binding|RNA binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGAGCTGCAGTTAACTGTTGA	0.358000													18	71					0	0	0.175082	0	0	
Unknown	0	broad.mit.edu	37	2	89246993	89246993	+	RNA	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr2:89246993C>T	uc010ytr.1	-	101		c.8066G>A			uc002stl.2_Intron					Parts of antibodies, mostly variable regions.																		CTGGTTTCTGCTGATACCAGG	0.527000													38	125					0	0	0.074837	0	0	
MFSD9	84804	broad.mit.edu	37	2	103335079	103335079	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr2:103335079C>T	uc002tcb.2	-	6	1293	c.1225G>A	c.(1225-1227)GGC>AGC	p.G409S	MFSD9_uc010fja.2_RNA	NM_032718	NP_116107	Q8NBP5	MFSD9_HUMAN	major facilitator superfamily domain containing	409					transmembrane transport	integral to membrane|plasma membrane	transporter activity			ovary(2)|breast(2)	4						ATAAGGGTGCCGCTGGCCTGG	0.667000													12	40					0	0	0.132662	0	0	
CKAP2L	150468	broad.mit.edu	37	2	113514603	113514603	+	Silent	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr2:113514603C>T	uc002tie.2	-	4	424	c.345G>A	c.(343-345)AAG>AAA	p.K115K	CKAP2L_uc002tif.2_5'UTR|CKAP2L_uc010yxp.1_5'UTR|CKAP2L_uc010yxq.1_5'UTR	NM_152515	NP_689728	Q8IYA6	CKP2L_HUMAN	cytoskeleton associated protein 2-like	115						centrosome					0						TGCTAGAAGGCTTAGAGTATG	0.448000													48	191					0	0	0.139131	0	0	
SCN3A	6328	broad.mit.edu	37	2	166011006	166011006	+	Missense_Mutation	SNP	G	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr2:166011006G>T	uc002ucx.2	-	11	1828	c.1336C>A	c.(1336-1338)CAG>AAG	p.Q446K	SCN3A_uc002ucy.2_Missense_Mutation_p.Q446K|SCN3A_uc002ucz.2_Missense_Mutation_p.Q446K|SCN3A_uc002uda.1_Missense_Mutation_p.Q315K|SCN3A_uc002udb.1_Missense_Mutation_p.Q315K	NM_006922	NP_008853	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha	446						voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(4)|breast(3)|skin(2)|central_nervous_system(1)	10					Lamotrigine(DB00555)	AGCATCTGCTGAAATTCGGCC	0.398000													14	83					1.49906e-05	1.56846e-05	0.119110	1	0	
STK39	27347	broad.mit.edu	37	2	169018346	169018346	+	Missense_Mutation	SNP	C	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr2:169018346C>A	uc002uea.2	-	5	739	c.579G>T	c.(577-579)TTG>TTT	p.L193F		NM_013233	NP_037365	Q9UEW8	STK39_HUMAN	serine threonine kinase 39 (STE20/SPS1 homolog,	193	Protein kinase.				response to stress	cytoplasm|nucleus	ATP binding|protein binding|receptor signaling protein serine/threonine kinase activity			central_nervous_system(1)|skin(1)	2						TACCAGCTTTCAAATCCCTAT	0.308000													5	37					1.23904e-05	1.30852e-05	0.014758	1	0	
ECEL1	9427	broad.mit.edu	37	2	233350955	233350955	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr2:233350955G>A	uc002vsv.2	-	2	614	c.409C>T	c.(409-411)CGC>TGC	p.R137C	ECEL1_uc010fya.1_Missense_Mutation_p.R137C|ECEL1_uc010fyb.1_5'UTR	NM_004826	NP_004817	O95672	ECEL1_HUMAN	endothelin converting enzyme-like 1	137	Lumenal (Potential).				neuropeptide signaling pathway|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity			central_nervous_system(2)	2		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;7.17e-17)|BRCA - Breast invasive adenocarcinoma(100;0.000771)|Lung(119;0.00213)|LUSC - Lung squamous cell carcinoma(224;0.00746)		ATGGCGTGGCGCCGCAGCCAA	0.642000													6	18					0	0	0.029380	0	0	
PDCD1	5133	broad.mit.edu	37	2	242794972	242794972	+	Silent	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr2:242794972C>T	uc002wcq.3	-	2	305	c.237G>A	c.(235-237)CTG>CTA	p.L79L	PDCD1_uc010fzs.2_Silent_p.L10L|PDCD1_uc010fzt.2_Intron	NM_005018	NP_005009	Q15116	PDCD1_HUMAN	programmed cell death 1 precursor	79	Ig-like V-type.|Extracellular (Potential).				apoptosis|humoral immune response|multicellular organismal development|T cell costimulation	integral to membrane	protein tyrosine phosphatase activity|signal transducer activity			ovary(1)	1		all_cancers(19;1.09e-40)|all_epithelial(40;2.03e-18)|Breast(86;1.53e-05)|all_lung(227;0.00338)|Renal(207;0.00502)|Ovarian(221;0.00716)|Lung NSC(271;0.012)|Esophageal squamous(248;0.129)|Melanoma(123;0.144)|all_hematologic(139;0.158)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;3.84e-33)|all cancers(36;8.08e-31)|OV - Ovarian serous cystadenocarcinoma(60;7.41e-15)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;3.23e-08)|BRCA - Breast invasive adenocarcinoma(100;1.63e-06)|Lung(119;0.000152)|LUSC - Lung squamous cell carcinoma(224;0.00154)|Colorectal(34;0.0129)|COAD - Colon adenocarcinoma(134;0.0219)		GGAAGGCGGCCAGCTTGTCCG	0.632000													8	33					0	0	0.038147	0	0	
ENTPD6	955	broad.mit.edu	37	20	25187932	25187932	+	Missense_Mutation	SNP	G	A	A	rs140692182	byFrequency	TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr20:25187932G>A	uc002wuj.2	+	3	455	c.275G>A	c.(274-276)GGG>GAG	p.G92E	ENTPD6_uc010zsy.1_Missense_Mutation_p.G92E|ENTPD6_uc010gdj.1_Missense_Mutation_p.G64E|ENTPD6_uc010zsz.1_Intron|ENTPD6_uc002wum.2_Missense_Mutation_p.G75E|ENTPD6_uc010zta.1_Missense_Mutation_p.G92E|ENTPD6_uc002wun.2_Missense_Mutation_p.G92E|ENTPD6_uc002wuk.2_Missense_Mutation_p.G91E|ENTPD6_uc002wul.2_Missense_Mutation_p.G91E|ENTPD6_uc010ztb.1_Missense_Mutation_p.G64E|ENTPD6_uc010ztc.1_Missense_Mutation_p.G64E|ENTPD6_uc002wuo.2_Intron|ENTPD6_uc010ztd.1_5'Flank	NM_001247	NP_001238	O75354	ENTP6_HUMAN	ectonucleoside triphosphate diphosphohydrolase 6	92	Lumenal (Potential).					Golgi membrane|integral to membrane	nucleoside-diphosphatase activity				0						AGCCCCCTGGGGACAGCTGCA	0.662000													6	36					0	0	0.029380	0	0	
C20orf160	140706	broad.mit.edu	37	20	30605902	30605902	+	Missense_Mutation	SNP	C	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr20:30605902C>A	uc002wxf.2	+	4	416	c.403C>A	c.(403-405)CAC>AAC	p.H135N		NM_080625	NP_542192	Q9NUG4	CT160_HUMAN	hypothetical protein LOC140706	135										central_nervous_system(3)|ovary(1)	4						AATCCCTACGCACGAGATCGC	0.552000													7	19					0.00198382	0.00200153	0.029380	1	0	
CEP250	11190	broad.mit.edu	37	20	34063452	34063452	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr20:34063452T>G	uc002xcm.2	+	16	2368	c.1697T>G	c.(1696-1698)GTG>GGG	p.V566G	CEP250_uc010zve.1_5'UTR|CEP250_uc010zvd.1_Intron	NM_007186	NP_009117	Q9BV73	CP250_HUMAN	centrosomal protein 2	566	Gln/Glu-rich.|Potential.				centriole-centriole cohesion|G2/M transition of mitotic cell cycle|protein localization|regulation of centriole-centriole cohesion	centriole|cilium|cytosol|microtubule basal body|perinuclear region of cytoplasm|protein complex	protein C-terminus binding|protein kinase binding			ovary(4)|central_nervous_system(1)	5	Lung NSC(9;0.00156)|all_lung(11;0.00243)		BRCA - Breast invasive adenocarcinoma(18;0.0106)			CAAACGGAAGTGACCGCAGCG	0.567000													22	115					0	0	0.083992	0	0	
SEMG2	6407	broad.mit.edu	37	20	43851491	43851491	+	Missense_Mutation	SNP	A	G	G			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr20:43851491A>G	uc010ggz.2	+	2	1275	c.1218A>G	c.(1216-1218)ATA>ATG	p.I406M	SEMG2_uc002xnk.2_Missense_Mutation_p.I406M|SEMG2_uc002xnl.2_Intron	NM_003008	NP_002999	Q02383	SEMG2_HUMAN	semenogelin II precursor	406	Repeat-rich region.|4 X 60 AA tandem repeats, type I.				sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(1)	1		Myeloproliferative disorder(115;0.0122)				AAAATAAAATATCATACCAAT	0.383000													12	120					0	0	0.105934	0	0	
SEMG2	6407	broad.mit.edu	37	20	43851686	43851686	+	Silent	SNP	A	G	G			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr20:43851686A>G	uc010ggz.2	+	2	1470	c.1413A>G	c.(1411-1413)TCA>TCG	p.S471S	SEMG2_uc002xnk.2_Silent_p.S471S|SEMG2_uc002xnl.2_Intron	NM_003008	NP_002999	Q02383	SEMG2_HUMAN	semenogelin II precursor	471	Repeat-rich region.|4 X 60 AA tandem repeats, type I.				sexual reproduction	extracellular space|stored secretory granule	structural molecule activity			skin(1)	1		Myeloproliferative disorder(115;0.0122)				ACCAATCTTCAAGTACAGAAG	0.383000													8	134					0	0	0.038147	0	0	
CHRNA4	1137	broad.mit.edu	37	20	61990948	61990948	+	Missense_Mutation	SNP	G	T	T	rs112051150		TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr20:61990948G>T	uc002yes.2	-	2	358	c.180C>A	c.(178-180)GAC>GAA	p.D60E	CHRNA4_uc002yet.1_Intron|CHRNA4_uc011aaw.1_RNA|CHRNA4_uc010gke.1_5'UTR|CHRNA4_uc002yev.1_5'UTR|CHRNA4_uc010gkf.1_5'UTR	NM_000744	NP_000735	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 subunit	60	Extracellular (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	CGAGGACCACGTCCGAGATGT	0.632000													20	40					3.5997e-14	4.17196e-14	0.069288	1	0	
KRTAP24-1	643803	broad.mit.edu	37	21	31654953	31654953	+	Missense_Mutation	SNP	C	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr21:31654953C>A	uc002ynv.2	-	1	324	c.298G>T	c.(298-300)GCA>TCA	p.A100S		NM_001085455	NP_001078924	Q3LI83	KR241_HUMAN	keratin associated protein 24-1	100						keratin filament	structural molecule activity				0						ACTTGGCCTGCTGATGGGGAG	0.403000													21	59					6.33239e-15	7.3769e-15	0.055883	1	0	
KRTAP27-1	643812	broad.mit.edu	37	21	31709591	31709591	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr21:31709591T>G	uc002ynx.1	-	1	422	c.396A>C	c.(394-396)CAA>CAC	p.Q132H		NM_001077711	NP_001071179	Q3LI81	KR271_HUMAN	keratin associated protein 27-1	132						intermediate filament				ovary(2)	2						GGCTTGCAGGTTGGCAGCTCT	0.493000													44	180					0	0	0.111260	0	0	
TIAM1	7074	broad.mit.edu	37	21	32624274	32624274	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr21:32624274C>T	uc002yow.1	-	6	1667	c.1195G>A	c.(1195-1197)GAG>AAG	p.E399K	TIAM1_uc011adk.1_Missense_Mutation_p.E399K|TIAM1_uc011adl.1_Missense_Mutation_p.E399K|TIAM1_uc002yox.1_Missense_Mutation_p.E7K	NM_003253	NP_003244	Q13009	TIAM1_HUMAN	T-cell lymphoma invasion and metastasis 1	399					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cell-cell junction|cytosol	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			lung(3)|breast(3)|ovary(2)|large_intestine(2)	10						TCCAGGCTCTCGCTGTTGGTG	0.692000													11	68					0	0	0.093190	0	0	
HLCS	3141	broad.mit.edu	37	21	38128941	38128941	+	Silent	SNP	G	T	T	rs150263699	byFrequency	TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr21:38128941G>T	uc010gnb.2	-	10	3112	c.1911C>A	c.(1909-1911)ATC>ATA	p.I637I	HLCS_uc002yvs.2_Silent_p.I637I	NM_000411	NP_000402	P50747	BPL1_HUMAN	holocarboxylase synthetase	637					cell proliferation|histone biotinylation|response to biotin	chromatin|cytosol|mitochondrion|nuclear lamina|nuclear matrix	ATP binding|biotin binding|biotin-[acetyl-CoA-carboxylase] ligase activity|biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity|biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity|biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity|enzyme binding			ovary(2)|breast(1)|kidney(1)|liver(1)	5		Myeloproliferative disorder(46;0.0422)			Biotin(DB00121)	CGACTCTGGCGATGAGATAAT	0.473000													24	117					4.26978e-12	4.92331e-12	0.083992	1	0	
BRWD1	54014	broad.mit.edu	37	21	40590130	40590130	+	Missense_Mutation	SNP	A	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr21:40590130A>T	uc002yxk.1	-	31	3746	c.3607T>A	c.(3607-3609)TAT>AAT	p.Y1203N	BRWD1_uc010goc.1_Intron|BRWD1_uc002yxl.2_Missense_Mutation_p.Y1203N|BRWD1_uc010god.1_Missense_Mutation_p.Y169N	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	1203	Bromo 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				TCGGTTGGATAAGCTACTACA	0.368000													5	60					0	0	0.014758	0	0	
U2AF1	7307	broad.mit.edu	37	21	44514835	44514835	+	Nonsense_Mutation	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr21:44514835G>A	uc002zda.1	-	6	496	c.412C>T	c.(412-414)CAG>TAG	p.Q138*	U2AF1_uc002zcy.1_Nonsense_Mutation_p.Q65*|U2AF1_uc002zcz.1_Nonsense_Mutation_p.Q65*|U2AF1_uc002zdb.1_Nonsense_Mutation_p.Q138*|U2AF1_uc010gpi.1_Nonsense_Mutation_p.Q138*	NM_001025203	NP_001020374	Q01081	U2AF1_HUMAN	U2 small nuclear RNA auxillary factor 1 isoform	138	RRM.				mRNA 3'-end processing|mRNA export from nucleus|termination of RNA polymerase II transcription	Cajal body|catalytic step 2 spliceosome|nuclear speck	nucleotide binding|RNA binding|zinc ion binding				0						TGGATCGGCTGTCCATTAAAC	0.532000													12	39					0	0	0.080935	0	0	
SLC7A4	6545	broad.mit.edu	37	22	21385491	21385491	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr22:21385491A>C	uc002zud.2	-	2	679	c.611T>G	c.(610-612)CTT>CGT	p.L204R	SLC7A4_uc002zue.2_Missense_Mutation_p.L204R	NM_004173	NP_004164	O43246	CTR4_HUMAN	solute carrier family 7 (cationic amino acid	204	Helical; (Potential).				cellular amino acid metabolic process	integral to membrane	basic amino acid transmembrane transporter activity			ovary(1)|lung(1)	2	all_cancers(11;2.85e-22)|Lung NSC(8;4.21e-14)|all_lung(8;6.08e-13)|Melanoma(16;0.000465)|Ovarian(15;0.0028)|Colorectal(54;0.0968)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.000204)|Lung(15;0.00494)|Epithelial(17;0.195)		L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	GAGAATGACAAGCAGGCTGAT	0.602000													7	52					0	0	0.038147	0	0	
DDT	1652	broad.mit.edu	37	22	24313812	24313812	+	Silent	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr22:24313812C>T	uc002zyz.3	-	3	362	c.285G>A	c.(283-285)CGG>CGA	p.R95R	DDT_uc011ajf.1_Intron|DDTL_uc002zyy.3_3'UTR|DDT_uc002zza.3_Silent_p.R95R	NM_001084392	NP_001077861	P30046	DOPD_HUMAN	D-dopachrome tautomerase	95					melanin biosynthetic process	cytoplasm	D-dopachrome decarboxylase activity|dopachrome isomerase activity|protein binding				0						GGATAAGTATCCTTCAGGAGA	0.507000													7	33					0	0	0.029380	0	0	
GRAP2	9402	broad.mit.edu	37	22	40365500	40365500	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr22:40365500G>A	uc003ayh.1	+	7	1039	c.776G>A	c.(775-777)CGG>CAG	p.R259Q	GRAP2_uc003ayi.2_RNA|GRAP2_uc011aom.1_Missense_Mutation_p.R233Q|GRAP2_uc011aon.1_Missense_Mutation_p.R193Q|GRAP2_uc010gya.1_Missense_Mutation_p.R259Q|GRAP2_uc011aoo.1_Missense_Mutation_p.R187Q|GRAP2_uc011aop.1_Missense_Mutation_p.R219Q|GRAP2_uc011aoq.1_Missense_Mutation_p.R146Q|GRAP2_uc003ayj.1_Missense_Mutation_p.R259Q	NM_004810	NP_004801	O75791	GRAP2_HUMAN	GRB2-related adaptor protein 2	259					cell-cell signaling|Ras protein signal transduction|T cell costimulation|T cell receptor signaling pathway	cytosol	SH3/SH2 adaptor activity			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						CTCATGCATCGGAGACACACA	0.572000													18	47					0	0	0.160694	0	0	
CRBN	51185	broad.mit.edu	37	3	3192625	3192625	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr3:3192625G>A	uc003bpq.2	-	11	1272	c.1253C>T	c.(1252-1254)ACG>ATG	p.T418M	CRBN_uc003bpr.2_Missense_Mutation_p.T417M|CRBN_uc010hbw.2_Missense_Mutation_p.T374M	NM_016302	NP_057386	Q96SW2	CRBN_HUMAN	cereblon	418	Thalidomide-binding.				proteasomal ubiquitin-dependent protein catabolic process|protein ubiquitination	Cul4A-RING ubiquitin ligase complex|cytoplasm|membrane|nucleus	ATP-dependent peptidase activity|protein binding			ovary(1)	1				Epithelial(13;0.00244)|OV - Ovarian serous cystadenocarcinoma(96;0.00617)|all cancers(10;0.0079)		AGCAGATCGCGTTAAGCCCCA	0.428000													9	36					0	0	0.047766	0	0	
JAGN1	84522	broad.mit.edu	37	3	9934908	9934908	+	Silent	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr3:9934908C>T	uc003btt.3	+	2	535	c.399C>T	c.(397-399)GGC>GGT	p.G133G	CIDEC_uc003bto.2_Intron	NM_032492	NP_115881	Q8N5M9	JAGN1_HUMAN	jagunal homolog 1	133	Lumenal (Potential).					endoplasmic reticulum membrane|integral to membrane				ovary(1)	1	Medulloblastoma(99;0.227)					ACCGCCATGGCAAGGCCTACC	0.522000													13	81					0	0	0.105934	0	0	
SUSD5	26032	broad.mit.edu	37	3	33194911	33194911	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr3:33194911C>T	uc003cfo.1	-	5	1631	c.1213G>A	c.(1213-1215)GTC>ATC	p.V405I		NM_015551	NP_056366	O60279	SUSD5_HUMAN	sushi domain containing 5 precursor	405	Extracellular (Potential).				cell adhesion	integral to membrane	hyaluronic acid binding			ovary(1)|central_nervous_system(1)	2						GTAACTAGGACGTTTTCATCC	0.532000													7	24					0	0	0.029380	0	0	
LRRFIP2	9209	broad.mit.edu	37	3	37114295	37114295	+	Missense_Mutation	SNP	C	G	G			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr3:37114295C>G	uc003cgp.2	-	22	1873	c.1450G>C	c.(1450-1452)GAT>CAT	p.D484H	LRRFIP2_uc011ayf.1_Missense_Mutation_p.D300H|LRRFIP2_uc003cgr.2_Intron|LRRFIP2_uc003cgs.3_Intron|LRRFIP2_uc003cgt.3_Intron	NM_006309	NP_006300	Q9Y608	LRRF2_HUMAN	leucine rich repeat (in FLII) interacting	484	Potential.				Wnt receptor signaling pathway		LRR domain binding			ovary(1)	1						ATTTTTTTATCTTTCCAAAGA	0.418000													8	60					0	0	0.047766	0	0	
CELSR3	1951	broad.mit.edu	37	3	48683606	48683606	+	Silent	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr3:48683606C>T	uc003cul.2	-	22	7661	c.7380G>A	c.(7378-7380)GAG>GAA	p.E2460E	CELSR3_uc003cuf.1_Silent_p.E2530E|CELSR3_uc010hkf.2_5'Flank|CELSR3_uc010hkg.2_Silent_p.E443E	NM_001407	NP_001398	Q9NYQ7	CELR3_HUMAN	cadherin EGF LAG seven-pass G-type receptor 3	2460	Extracellular (Potential).				homophilic cell adhesion|multicellular organismal development|neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity|protein binding			ovary(5)|upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)	11				BRCA - Breast invasive adenocarcinoma(193;0.000292)|KIRC - Kidney renal clear cell carcinoma(197;0.00549)|Kidney(197;0.00619)		TGATGGGGGACTCCAGGATTC	0.602000													9	25					0	0	0.047766	0	0	
NISCH	11188	broad.mit.edu	37	3	52521725	52521725	+	Silent	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr3:52521725C>T	uc011beg.1	+	17	2289	c.2217C>T	c.(2215-2217)TTC>TTT	p.F739F	NISCH_uc003ded.3_Silent_p.F739F|NISCH_uc003dee.3_Silent_p.F228F|NISCH_uc003deg.1_RNA	NM_007184	NP_009115	Q9Y2I1	NISCH_HUMAN	nischarin	739	Interaction with LIMK (By similarity).|Interaction with ITGA5 (By similarity).|Interaction with PAK1 (By similarity).				apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			ovary(3)|central_nervous_system(1)	4				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		TCGCAGTCTTCGAGATCCCGC	0.612000													22	72					0	0	0.069288	0	0	
ARL13B	200894	broad.mit.edu	37	3	93768322	93768322	+	Missense_Mutation	SNP	A	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr3:93768322A>T	uc003drc.2	+	8	1383	c.1097A>T	c.(1096-1098)GAC>GTC	p.D366V	ARL13B_uc010hop.2_Missense_Mutation_p.D217V|ARL13B_uc003drd.2_Missense_Mutation_p.D259V|ARL13B_uc003dre.2_Missense_Mutation_p.D351V|ARL13B_uc003drf.2_Missense_Mutation_p.D366V|ARL13B_uc003drg.2_Missense_Mutation_p.D263V	NM_182896	NP_878899	Q3SXY8	AR13B_HUMAN	ADP-ribosylation factor-like 2-like 1 isoform 1	366							GTP binding				0						AATATAGATGACTGTGCTCCT	0.378000													21	58					0	0	0.076483	0	0	
SMC4	10051	broad.mit.edu	37	3	160148502	160148502	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr3:160148502G>A	uc003fdh.2	+	19	3024	c.2911G>A	c.(2911-2913)GAG>AAG	p.E971K	IFT80_uc003fda.2_Intron|SMC4_uc003fdi.2_Missense_Mutation_p.E946K|SMC4_uc003fdj.2_Missense_Mutation_p.E971K|SMC4_uc010hwd.2_Missense_Mutation_p.E971K|SMC4_uc003fdl.2_Missense_Mutation_p.E674K	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes	971	Potential.				cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			CAAAGCAGCAGAGGTCGTAAA	0.408000													11	60					0	0	0.093190	0	0	
SMC4	10051	broad.mit.edu	37	3	160150896	160150896	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr3:160150896T>G	uc003fdh.2	+	23	3726	c.3613T>G	c.(3613-3615)TTT>GTT	p.F1205V	IFT80_uc003fda.2_Intron|SMC4_uc003fdi.2_Missense_Mutation_p.F1180V|SMC4_uc003fdj.2_Missense_Mutation_p.F1205V|SMC4_uc010hwd.2_Missense_Mutation_p.F1147V|SMC4_uc003fdl.2_Missense_Mutation_p.F908V	NM_001002800	NP_001002800	Q9NTJ3	SMC4_HUMAN	SMC4 structural maintenance of chromosomes	1205	Ala/Asp-rich (DA-box).				cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			ovary(1)|breast(1)	2			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			GGCTTTAGTATTTGCTCTTCA	0.368000													24	109					0	0	0.083992	0	0	
MCCC1	56922	broad.mit.edu	37	3	182733324	182733324	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr3:182733324C>T	uc003fle.2	-	19	2217	c.2080G>A	c.(2080-2082)GTA>ATA	p.V694I	MCCC1_uc010hxi.2_RNA|MCCC1_uc011bqo.1_RNA|MCCC1_uc003flf.2_Missense_Mutation_p.V577I|MCCC1_uc003flg.2_Missense_Mutation_p.V585I	NM_020166	NP_064551	Q96RQ3	MCCA_HUMAN	methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)	694	Biotinyl-binding.				biotin metabolic process|leucine catabolic process	mitochondrial inner membrane|mitochondrial matrix	ATP binding|biotin binding|biotin carboxylase activity|metal ion binding|methylcrotonoyl-CoA carboxylase activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(143;1.84e-14)|Ovarian(172;0.0355)		all cancers(12;1.8e-44)|Epithelial(37;3.23e-38)|LUSC - Lung squamous cell carcinoma(7;5.04e-25)|Lung(8;5.03e-23)|OV - Ovarian serous cystadenocarcinoma(80;5.07e-21)		Biotin(DB00121)	ACTTTCTTTACTGTGCCATCC	0.433000													37	147					0	0	0.080422	0	0	
C3orf70	285382	broad.mit.edu	37	3	184801261	184801261	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr3:184801261T>G	uc003fpd.2	-	2	478	c.287A>C	c.(286-288)CAG>CCG	p.Q96P		NM_001025266	NP_001020437	A6NLC5	CC070_HUMAN	hypothetical protein LOC285382	96											0						GACTGAGATCTGAATGGTGTT	0.502000													21	100					0	0	0.055883	0	0	
BCL6	604	broad.mit.edu	37	3	187447510	187447510	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr3:187447510C>T	uc003frp.3	-	5	1140	c.683G>A	c.(682-684)CGG>CAG	p.R228Q	BCL6_uc011bsf.1_Missense_Mutation_p.R228Q|BCL6_uc010hza.2_Missense_Mutation_p.R126Q|BCL6_uc003frq.1_Missense_Mutation_p.R228Q	NM_001130845	NP_001124317	P41182	BCL6_HUMAN	B-cell lymphoma 6 protein isoform 1	228					negative regulation of B cell apoptosis|negative regulation of cell growth|negative regulation of S phase of mitotic cell cycle|negative regulation of transcription from RNA polymerase II promoter|positive regulation of apoptosis|protein import into nucleus, translocation|regulation of germinal center formation|response to DNA damage stimulus	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|lung(2)|central_nervous_system(1)	5	all_cancers(143;9.45e-12)|Ovarian(172;0.0418)		OV - Ovarian serous cystadenocarcinoma(80;1.76e-18)	GBM - Glioblastoma multiforme(93;0.0141)		TGGGAGTGCCCGCTCCTTGGG	0.587000			T|Mis	IG loci|ZNFN1A1|LCP1|PIM1|TFRC|MHC2TA|NACA|HSPCB|HSPCA|HIST1H4I|IL21R| POU2AF1|ARHH|EIF4A2|SFRS3	NHL|CLL								9	29					0	0	0.047766	0	0	
PDGFRA	5156	broad.mit.edu	37	4	55133725	55133725	+	Missense_Mutation	SNP	G	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr4:55133725G>T	uc003han.3	+	7	1269	c.938G>T	c.(937-939)GGT>GTT	p.G313V	PDGFRA_uc003haa.2_Intron|PDGFRA_uc010igq.1_Missense_Mutation_p.G207V|PDGFRA_uc003ham.2_RNA	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	313	Extracellular (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	ACAGAGAAAGGTTTCATTGAA	0.448000			Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			9	78					0.000673444	0.000685578	0.069234	1	0	
TMEM165	55858	broad.mit.edu	37	4	56277800	56277800	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr4:56277800C>T	uc003hax.2	+	2	494	c.227C>T	c.(226-228)GCT>GTT	p.A76V	TMEM165_uc011bzy.1_Missense_Mutation_p.A13V	NM_018475	NP_060945	Q9HC07	TM165_HUMAN	transmembrane protein 165	76						integral to membrane					0	Lung NSC(11;0.00545)|Glioma(25;0.08)|all_neural(26;0.101)|all_epithelial(27;0.135)		LUSC - Lung squamous cell carcinoma(4;1.62e-07)|Lung(4;1.34e-06)|Epithelial(7;0.0103)			ACACCAGCAGCTCCAGTTCAT	0.289000													11	52					0	0	0.069234	0	0	
HERC5	51191	broad.mit.edu	37	4	89388332	89388332	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr4:89388332C>T	uc003hrt.2	+	7	1187	c.1034C>T	c.(1033-1035)TCA>TTA	p.S345L	HERC5_uc011cdm.1_5'Flank	NM_016323	NP_057407	Q9UII4	HERC5_HUMAN	hect domain and RLD 5	345	RCC1 5.				innate immune response|ISG15-protein conjugation|negative regulation of type I interferon production|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|regulation of cyclin-dependent protein kinase activity|regulation of defense response to virus|response to virus	cytosol|perinuclear region of cytoplasm	ISG15 ligase activity|protein binding|ubiquitin-protein ligase activity			ovary(4)|lung(3)|skin(2)	9		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000209)		GTGAAAGTATCATCAAGTGAA	0.393000													22	72					0	0	0.062417	0	0	
MMRN1	22915	broad.mit.edu	37	4	90856716	90856716	+	Missense_Mutation	SNP	G	C	C			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr4:90856716G>C	uc003hst.2	+	6	1956	c.1885G>C	c.(1885-1887)GAC>CAC	p.D629H	MMRN1_uc010iku.2_Intron|MMRN1_uc011cds.1_Missense_Mutation_p.D371H	NM_007351	NP_031377	Q13201	MMRN1_HUMAN	multimerin 1	629	Potential.				cell adhesion|platelet activation|platelet degranulation	extracellular region|platelet alpha granule lumen				ovary(4)	4		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;6.96e-05)		CTTTCCAATGGACAATAAGAT	0.363000													21	111					0	0	0.076483	0	0	
PDHA2	5161	broad.mit.edu	37	4	96762399	96762399	+	Silent	SNP	C	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr4:96762399C>A	uc003htr.3	+	1	1161	c.1098C>A	c.(1096-1098)ATC>ATA	p.I366I		NM_005390	NP_005381	P29803	ODPAT_HUMAN	pyruvate dehydrogenase E1 alpha 2 precursor	366					glycolysis	mitochondrial matrix	pyruvate dehydrogenase (acetyl-transferring) activity			central_nervous_system(1)	1		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;1.23e-06)	NADH(DB00157)	GCCATCACATCTACAGCAGTG	0.433000													23	76					2.70639e-06	2.88512e-06	0.069288	1	0	
PRDM9	56979	broad.mit.edu	37	5	23521209	23521209	+	Missense_Mutation	SNP	T	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr5:23521209T>A	uc003jgo.2	+	6	611	c.429T>A	c.(427-429)AGT>AGA	p.S143R		NM_020227	NP_064612	Q9NQV7	PRDM9_HUMAN	PR domain containing 9	143					meiosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleoplasm	histone-lysine N-methyltransferase activity|nucleic acid binding|zinc ion binding			ovary(3)|large_intestine(2)|pancreas(1)	6						TGAATGCAAGTGGCTCAGAGC	0.423000										HNSCC(3;0.000094)			12	68					0	0	0.093190	0	0	
PRKAA1	5562	broad.mit.edu	37	5	40764627	40764627	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr5:40764627C>T	uc003jmc.2	-	8	1430	c.1424G>A	c.(1423-1425)CGT>CAT	p.R475H	PRKAA1_uc003jmb.2_Missense_Mutation_p.R490H	NM_006251	NP_006242	Q13131	AAPK1_HUMAN	protein kinase, AMP-activated, alpha 1 catalytic	475					activation of MAPK activity|cell cycle arrest|cholesterol biosynthetic process|fatty acid biosynthetic process|insulin receptor signaling pathway|negative regulation of glucosylceramide biosynthetic process|positive regulation of anti-apoptosis|positive regulation of cholesterol biosynthetic process|regulation of fatty acid oxidation|response to hypoxia	cytosol	ATP binding|cAMP-dependent protein kinase activity|metal ion binding|protein binding			breast(1)	1					Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)|Phenformin(DB00914)	ATCAATACTACGGAAATCCAG	0.368000													7	32					0	0	0.029380	0	0	
PIK3R1	5295	broad.mit.edu	37	5	67589663	67589663	+	Splice_Site	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr5:67589663G>A	uc003jva.2	+	11	1985	c.1425_splice	c.e11+1	p.Q475_splice	PIK3R1_uc003jvb.2_Splice_Site_p.Q475_splice|PIK3R1_uc003jvc.2_Splice_Site_p.Q175_splice|PIK3R1_uc003jvd.2_Splice_Site_p.Q205_splice|PIK3R1_uc003jve.2_Splice_Site_p.Q154_splice|PIK3R1_uc011crb.1_Splice_Site_p.Q145_splice	NM_181523	NP_852664	P27986	P85A_HUMAN	phosphoinositide-3-kinase, regulatory subunit 1						epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|growth hormone receptor signaling pathway|insulin receptor signaling pathway|insulin-like growth factor receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol phosphorylation|phosphatidylinositol-mediated signaling|platelet activation|positive regulation of establishment of protein localization in plasma membrane|positive regulation of glucose import|T cell costimulation|T cell receptor signaling pathway	1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex	1-phosphatidylinositol binding|ErbB-3 class receptor binding|insulin binding|insulin receptor binding|insulin receptor substrate binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase regulator activity|protein phosphatase binding	p.D434_Q475del(1)|p.?(1)		endometrium(34)|central_nervous_system(27)|large_intestine(20)|breast(7)|ovary(5)|haematopoietic_and_lymphoid_tissue(3)|lung(2)|urinary_tract(1)|skin(1)|pancreas(1)	101		Lung NSC(167;1.99e-05)|Prostate(74;0.00308)|Ovarian(174;0.00473)|Colorectal(97;0.0176)		OV - Ovarian serous cystadenocarcinoma(47;3.76e-51)|Lung(70;0.0211)	Isoproterenol(DB01064)	CACATCCCAGGTGAGTTTTCT	0.294000			Mis|F|O		gliobastoma|ovarian|colorectal					TCGA GBM(4;<1E-08)			16	61					0	0	0.132662	0	0	
RAD17	5884	broad.mit.edu	37	5	68692242	68692242	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr5:68692242G>A	uc003jwo.2	+	13	1536	c.1474G>A	c.(1474-1476)GAA>AAA	p.E492K	RAD17_uc003jwg.2_Missense_Mutation_p.E481K|RAD17_uc003jwh.2_Missense_Mutation_p.E481K|RAD17_uc003jwi.2_Missense_Mutation_p.E481K|RAD17_uc003jwj.2_Missense_Mutation_p.E481K|RAD17_uc003jwk.2_Missense_Mutation_p.E481K|RAD17_uc003jwl.2_Missense_Mutation_p.E481K|RAD17_uc003jwm.2_Missense_Mutation_p.E316K|RAD17_uc003jwn.2_Missense_Mutation_p.E395K|RAD17_uc003jwp.2_Missense_Mutation_p.E52K	NM_133339	NP_579917	O75943	RAD17_HUMAN	RAD17 homolog isoform 2	492	Interaction with MCM7.				cell cycle|DNA damage checkpoint|DNA repair|DNA replication|DNA replication checkpoint|mitotic cell cycle checkpoint|negative regulation of DNA replication|regulation of phosphorylation	nucleoplasm	ATP binding|nucleoside-triphosphatase activity|protein binding				0		Lung NSC(167;5.19e-05)|Prostate(74;0.0143)|Ovarian(174;0.0448)|Breast(144;0.198)		OV - Ovarian serous cystadenocarcinoma(47;9.36e-57)|Epithelial(20;1.21e-52)|all cancers(19;3.34e-48)|Lung(70;0.0183)		TTTACTCAGGGAATATAGCAC	0.383000								Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					4	30					0	0	0.150653	0	0	
ACOT12	134526	broad.mit.edu	37	5	80655815	80655815	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr5:80655815C>T	uc003khl.3	-	5	458	c.403G>A	c.(403-405)GTG>ATG	p.V135M	RNU5E_uc011cto.1_Intron|ACOT12_uc003khm.2_Missense_Mutation_p.V135M	NM_130767	NP_570123	Q8WYK0	ACO12_HUMAN	acyl-CoA thioesterase 12	135					acyl-CoA metabolic process|fatty acid metabolic process	cytosol	acetyl-CoA hydrolase activity|carboxylesterase activity			ovary(1)|kidney(1)	2		Lung NSC(167;0.0176)|all_lung(232;0.0205)|Ovarian(174;0.135)		OV - Ovarian serous cystadenocarcinoma(54;1.37e-45)|Epithelial(54;1.25e-39)|all cancers(79;5.01e-34)		TTATGTTCCACATGATCTTGT	0.323000													10	47					0	0	0.069234	0	0	
PKD2L2	27039	broad.mit.edu	37	5	137271538	137271538	+	Missense_Mutation	SNP	A	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr5:137271538A>T	uc003lby.2	+	13	1780	c.1724A>T	c.(1723-1725)AAG>ATG	p.K575M	PKD2L2_uc003lbw.1_Missense_Mutation_p.K575M|PKD2L2_uc003lbx.2_Missense_Mutation_p.K474M|PKD2L2_uc011cyi.1_Missense_Mutation_p.K183M	NM_014386	NP_055201	Q9NZM6	PK2L2_HUMAN	polycystic kidney disease 2-like 2	575	Cytoplasmic (Potential).|Potential.					integral to membrane	calcium ion binding|ion channel activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			CTTGAGAAAAAGTATTATTCT	0.378000													15	61					0	0	0.132662	0	0	
PCDHA1	56147	broad.mit.edu	37	5	140167716	140167716	+	Missense_Mutation	SNP	C	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr5:140167716C>A	uc003lhb.2	+	1	1841	c.1841C>A	c.(1840-1842)GCA>GAA	p.A614E	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lgz.2_Missense_Mutation_p.A614E	NM_018900	NP_061723	Q9Y5I3	PCDA1_HUMAN	protocadherin alpha 1 isoform 1 precursor	614	Cadherin 6.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	extracellular region|integral to plasma membrane	calcium ion binding|protein binding			skin(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CTGCAGCCGGCAGCAGGCGGC	0.677000													21	84					9.95505e-16	1.16572e-15	0.069288	1	0	
ARAP3	64411	broad.mit.edu	37	5	141053171	141053171	+	Splice_Site	SNP	C	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr5:141053171C>A	uc003llm.2	-	5	980	c.902_splice	c.e5+1	p.G301_splice	ARAP3_uc011dbe.1_5'Flank|ARAP3_uc003lln.2_Splice_Site_p.G223_splice|ARAP3_uc003llo.1_Splice_Site_p.G301_splice	NM_022481	NP_071926	Q8WWN8	ARAP3_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH						cytoskeleton organization|negative regulation of cell migration|negative regulation of Rho protein signal transduction|regulation of ARF GTPase activity|regulation of cell shape|small GTPase mediated signal transduction|vesicle-mediated transport	cytoskeleton|cytosol|lamellipodium|plasma membrane|ruffle	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|phosphatidylinositol-3,4-bisphosphate binding|Rho GTPase activator activity|zinc ion binding			breast(5)|ovary(1)|large_intestine(1)	7						CCAGCACCCACCCCTGAGGGG	0.622000													15	74					0.000219431	0.000225416	0.119110	1	0	
FAF2	23197	broad.mit.edu	37	5	175919208	175919208	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr5:175919208T>G	uc003mej.3	+	5	411	c.358T>G	c.(358-360)TTT>GTT	p.F120V		NM_014613	NP_055428	Q96CS3	FAF2_HUMAN	UBX domain containing 8	120					response to unfolded protein	endoplasmic reticulum|lipid particle	protein binding			ovary(1)	1						TGCTCTTCGTTTTATACGGCC	0.473000													33	110					0	0	0.173368	0	0	
CAGE1	285782	broad.mit.edu	37	6	7373629	7373629	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr6:7373629G>A	uc003mxi.2	-	4	1736	c.1015C>T	c.(1015-1017)CGG>TGG	p.R339W	CAGE1_uc003mxh.2_RNA|CAGE1_uc003mxj.2_Missense_Mutation_p.R230W|CAGE1_uc003mxk.1_Missense_Mutation_p.R230W	NM_205864	NP_995586	Q8TC20	CAGE1_HUMAN	cancer antigen 1	475	Potential.										0	Ovarian(93;0.0418)					TCTTTTTCCCGTTTCAACAAG	0.403000													12	30					0	0	0.093190	0	0	
BMP6	654	broad.mit.edu	37	6	7880471	7880471	+	Silent	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr6:7880471G>A	uc003mxu.3	+	7	1615	c.1437G>A	c.(1435-1437)GCG>GCA	p.A479A		NM_001718	NP_001709	P22004	BMP6_HUMAN	bone morphogenetic protein 6 preproprotein	479					BMP signaling pathway|cartilage development|growth|immune response|positive regulation of aldosterone biosynthetic process|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription from RNA polymerase II promoter|SMAD protein signal transduction	extracellular space	BMP receptor binding|cytokine activity|growth factor activity|protein heterodimerization activity			large_intestine(2)|ovary(1)	3	Ovarian(93;0.0721)					CGTGCTGTGCGCCAACTAAGC	0.448000													38	147					0	0	0.086207	0	0	
HIST1H2AG	8969	broad.mit.edu	37	6	27100904	27100904	+	Silent	SNP	C	G	G	rs147278636		TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr6:27100904C>G	uc003niw.2	+	1	88	c.54C>G	c.(52-54)CGC>CGG	p.R18R	HIST1H2BJ_uc003niu.1_5'Flank|HIST1H2BJ_uc003niv.2_5'Flank	NM_021064	NP_066408	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ag	18					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding				0						CCAAGACTCGCTCTTCTAGGG	0.647000													20	46					0	0	0.043863	0	0	
OR5V1	81696	broad.mit.edu	37	6	29323142	29323142	+	Missense_Mutation	SNP	C	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr6:29323142C>A	uc011dlo.1	-	1	913	c.831G>T	c.(829-831)TTG>TTT	p.L277F		NM_030876	NP_110503	Q9UGF6	OR5V1_HUMAN	olfactory receptor, family 5, subfamily V,	277	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(3)|kidney(1)	4						CAACACTGTACAACACTGAAA	0.418000													34	159					9.17885e-22	1.08608e-21	0.183431	1	0	
DNAH8	1769	broad.mit.edu	37	6	38835970	38835970	+	Missense_Mutation	SNP	C	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr6:38835970C>A	uc003ooe.1	+	46	6775	c.6175C>A	c.(6175-6177)CTG>ATG	p.L2059M		NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						CCTTTCCAAACTGGTATCTTC	0.388000													14	45					2.61681e-11	2.957e-11	0.119110	1	0	
BAI3	577	broad.mit.edu	37	6	69348940	69348940	+	Missense_Mutation	SNP	A	G	G			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr6:69348940A>G	uc003pev.3	+	3	821	c.373A>G	c.(373-375)AAA>GAA	p.K125E	BAI3_uc010kak.2_Missense_Mutation_p.K125E	NM_001704	NP_001695	O60242	BAI3_HUMAN	brain-specific angiogenesis inhibitor 3	125	CUB.|Extracellular (Potential).				negative regulation of angiogenesis|neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			lung(27)|ovary(8)|skin(6)|pancreas(4)|central_nervous_system(3)|urinary_tract(1)|breast(1)	50		all_lung(197;0.212)				ACAGTATGATAAAAATTTTAT	0.289000													16	42					0	0	0.146539	0	0	
RIMS1	22999	broad.mit.edu	37	6	72678732	72678732	+	Missense_Mutation	SNP	A	G	G			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr6:72678732A>G	uc003pga.2	+	2	288	c.211A>G	c.(211-213)AGA>GGA	p.R71G		NM_014989	NP_055804	Q86UR5	RIMS1_HUMAN	regulating synaptic membrane exocytosis 1	71	RabBD.				calcium ion-dependent exocytosis|cellular membrane fusion|glutamate secretion|intracellular protein transport|protein complex assembly|regulated secretory pathway|response to stimulus|synaptic vesicle exocytosis|visual perception	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(7)|pancreas(2)|breast(1)	10		all_epithelial(107;0.179)|all_hematologic(105;0.212)				CAAAACACCAAGAAATGCTGA	0.453000													28	97					0	0	0.116897	0	0	
DDX43	55510	broad.mit.edu	37	6	74123758	74123758	+	Missense_Mutation	SNP	G	C	C	rs139170485		TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr6:74123758G>C	uc003pgw.2	+	13	1906	c.1562G>C	c.(1561-1563)AGA>ACA	p.R521T		NM_018665	NP_061135	Q9NXZ2	DDX43_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 43	521	Helicase C-terminal.					intracellular	ATP binding|ATP-dependent RNA helicase activity|RNA binding			ovary(2)|upper_aerodigestive_tract(1)|skin(1)	4						CATGGAGATAGAGAACAGAGA	0.363000													12	45					0	0	0.093190	0	0	
SLC17A5	26503	broad.mit.edu	37	6	74351547	74351547	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr6:74351547C>T	uc003phn.3	-	3	520	c.392G>A	c.(391-393)AGC>AAC	p.S131N	SLC17A5_uc010kay.2_RNA|SLC17A5_uc011dyo.1_Silent_p.Q29Q	NM_012434	NP_036566	Q9NRA2	S17A5_HUMAN	sialin	131					anion transport	integral to plasma membrane|lysosomal membrane|membrane fraction	sialic acid:hydrogen symporter activity			skin(5)|central_nervous_system(1)	6						CCCTATTTTGCTGGCAACATA	0.473000													40	164					0	0	0.086207	0	0	
PGM3	5238	broad.mit.edu	37	6	83900610	83900610	+	Missense_Mutation	SNP	C	G	G			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr6:83900610C>G	uc003pjv.2	-	2	162	c.122G>C	c.(121-123)CGC>CCC	p.R41P	PGM3_uc003pjw.2_Intron|PGM3_uc011dyz.1_Missense_Mutation_p.R69P|RWDD2A_uc003pjx.3_5'Flank|RWDD2A_uc011dza.1_5'Flank	NM_015599	NP_056414	O95394	AGM1_HUMAN	phosphoglucomutase 3	41					dolichol-linked oligosaccharide biosynthetic process|embryo development ending in birth or egg hatching|glucose 1-phosphate metabolic process|hemopoiesis|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol	magnesium ion binding|phosphoacetylglucosamine mutase activity|phosphoglucomutase activity				0		all_cancers(76;0.000504)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.068)		BRCA - Breast invasive adenocarcinoma(397;0.0478)		TAATCCCATGCGAAACATGAC	0.458000													24	85					0	0	0.076483	0	0	
ASCC3	10973	broad.mit.edu	37	6	101094585	101094585	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr6:101094585G>A	uc003pqk.2	-	22	3868	c.3539C>T	c.(3538-3540)CCT>CTT	p.P1180L		NM_006828	NP_006819	Q8N3C0	HELC1_HUMAN	activating signal cointegrator 1 complex subunit	1180	SEC63 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|microtubule cytoskeleton	ATP binding|ATP-dependent helicase activity|nucleic acid binding			ovary(5)|skin(1)	6		all_cancers(76;1.45e-07)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(87;0.00149)|Hepatocellular(1;0.0893)|Colorectal(196;0.13)		BRCA - Breast invasive adenocarcinoma(108;0.0539)|all cancers(137;0.103)|GBM - Glioblastoma multiforme(226;0.199)		CATAACAGAAGGAATCTGATG	0.403000													8	47					0	0	0.038147	0	0	
QRSL1	55278	broad.mit.edu	37	6	107100220	107100220	+	Missense_Mutation	SNP	A	G	G	rs144191952		TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr6:107100220A>G	uc003prm.2	+	6	810	c.694A>G	c.(694-696)ATC>GTC	p.I232V	QRSL1_uc003prl.2_Missense_Mutation_p.I232V	NM_018292	NP_060762	Q9H0R6	QRSL1_HUMAN	glutaminyl-tRNA synthase	232					translation		ATP binding|carbon-nitrogen ligase activity, with glutamine as amido-N-donor				0	Breast(9;0.0107)|all_epithelial(6;0.14)	all_cancers(87;0.00768)|Acute lymphoblastic leukemia(125;2.27e-07)|all_hematologic(75;1.38e-05)|all_epithelial(87;0.248)	Epithelial(6;0.000334)|all cancers(7;0.00157)|BRCA - Breast invasive adenocarcinoma(8;0.00721)|OV - Ovarian serous cystadenocarcinoma(5;0.0152)	BRCA - Breast invasive adenocarcinoma(108;0.118)|all cancers(137;0.167)|Epithelial(106;0.176)		TGTGCCAGGAATCTTAACCAG	0.413000													24	99					0	0	0.091800	0	0	
SEC63	11231	broad.mit.edu	37	6	108234618	108234618	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr6:108234618C>T	uc003psc.3	-	5	735	c.466G>A	c.(466-468)GAG>AAG	p.E156K	SEC63_uc003psb.3_Missense_Mutation_p.E16K	NM_007214	NP_009145	Q9UGP8	SEC63_HUMAN	SEC63-like protein	156	J.|Lumenal (Potential).				protein folding|protein targeting to membrane	endoplasmic reticulum membrane|integral to membrane	heat shock protein binding|receptor activity|unfolded protein binding			ovary(1)|skin(1)	2		all_cancers(87;5.35e-06)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.00225)|Colorectal(196;0.0294)		BRCA - Breast invasive adenocarcinoma(108;0.0079)|Epithelial(106;0.0356)|all cancers(137;0.0525)|OV - Ovarian serous cystadenocarcinoma(136;0.054)		TTCCGGGACTCTTCATCCGTT	0.343000													34	123					0	0	0.064281	0	0	
TUBE1	51175	broad.mit.edu	37	6	112393234	112393234	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr6:112393234C>T	uc003pvq.2	-	11	1254	c.1140G>A	c.(1138-1140)TGG>TGA	p.W380*	TUBE1_uc003pvr.2_Nonsense_Mutation_p.W305*	NM_016262	NP_057346	Q9UJT0	TBE_HUMAN	tubulin, epsilon 1	380					centrosome cycle|microtubule-based movement|protein polymerization	microtubule|pericentriolar material	GTP binding|GTPase activity|structural constituent of cytoskeleton			ovary(1)	1		all_cancers(87;0.0101)|all_hematologic(75;0.000258)|Colorectal(196;0.0466)|all_epithelial(87;0.1)		all cancers(137;0.0217)|OV - Ovarian serous cystadenocarcinoma(136;0.0613)|Epithelial(106;0.0636)|GBM - Glioblastoma multiforme(226;0.0972)|BRCA - Breast invasive adenocarcinoma(108;0.246)		GGCTGGTCTTCCAGCCTTCTT	0.398000													18	78					0	0	0.049695	0	0	
SERINC1	57515	broad.mit.edu	37	6	122766247	122766247	+	Missense_Mutation	SNP	A	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr6:122766247A>T	uc003pyy.1	-	10	1374	c.1304T>A	c.(1303-1305)GTG>GAG	p.V435E	SERINC1_uc003pyx.1_RNA	NM_020755	NP_065806	Q9NRX5	SERC1_HUMAN	serine incorporator 1	435	Helical; (Potential).				phosphatidylserine metabolic process|phospholipid biosynthetic process|positive regulation of transferase activity|sphingolipid metabolic process	endoplasmic reticulum membrane|integral to membrane|plasma membrane	L-serine transmembrane transporter activity|protein binding			ovary(1)	1				GBM - Glioblastoma multiforme(226;0.126)		AACATACAGCACGATGCCAAT	0.413000													10	49					0	0	0.080935	0	0	
HDAC9	9734	broad.mit.edu	37	7	18631206	18631206	+	Missense_Mutation	SNP	A	C	C			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr7:18631206A>C	uc003suh.2	+	4	515	c.474A>C	c.(472-474)AAA>AAC	p.K158N	HDAC9_uc003sue.2_Missense_Mutation_p.K158N|HDAC9_uc011jyd.1_Missense_Mutation_p.K158N|HDAC9_uc003sui.2_Missense_Mutation_p.K161N|HDAC9_uc003suj.2_Missense_Mutation_p.K161N|HDAC9_uc011jya.1_Missense_Mutation_p.K199N|HDAC9_uc003sua.1_Missense_Mutation_p.K180N|HDAC9_uc011jyb.1_Missense_Mutation_p.K158N|HDAC9_uc003sud.1_Missense_Mutation_p.K158N|HDAC9_uc011jyc.1_Missense_Mutation_p.K161N|HDAC9_uc003suf.1_Missense_Mutation_p.K189N|HDAC9_uc010kud.1_Missense_Mutation_p.K161N|HDAC9_uc011jye.1_Missense_Mutation_p.K130N|HDAC9_uc011jyf.1_Missense_Mutation_p.K127N|HDAC9_uc010kue.1_5'UTR	NM_058176	NP_478056	Q9UKV0	HDAC9_HUMAN	histone deacetylase 9 isoform 1	158					B cell differentiation|cellular response to insulin stimulus|heart development|histone H3 deacetylation|histone H4 deacetylation|inflammatory response|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription, DNA-dependent|peptidyl-lysine deacetylation|positive regulation of cell migration involved in sprouting angiogenesis|regulation of skeletal muscle fiber development|transcription, DNA-dependent	cytoplasm|histone deacetylase complex|histone methyltransferase complex|transcription factor complex	histone deacetylase activity (H3-K16 specific)|histone deacetylase binding|histone deacetylase binding|NAD-dependent histone deacetylase activity (H3-K14 specific)|NAD-dependent histone deacetylase activity (H3-K9 specific)|NAD-dependent histone deacetylase activity (H4-K16 specific)|protein binding|protein kinase C binding|repressing transcription factor binding|transcription corepressor activity			lung(2)|central_nervous_system(2)|kidney(1)	5	all_lung(11;0.187)				Valproic Acid(DB00313)	CAGCAACGAAAGACACTCCAA	0.383000													11	30					0	0	0.080935	0	0	
WBSCR17	64409	broad.mit.edu	37	7	71036364	71036364	+	Missense_Mutation	SNP	G	C	C			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr7:71036364G>C	uc003tvy.2	+	6	1057	c.1057G>C	c.(1057-1059)GAA>CAA	p.E353Q	WBSCR17_uc003tvz.2_Missense_Mutation_p.E52Q	NM_022479	NP_071924	Q6IS24	GLTL3_HUMAN	UDP-GalNAc:polypeptide	353	Catalytic subdomain B.|Lumenal (Potential).					Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			skin(3)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)|central_nervous_system(1)	7		all_cancers(73;0.2)|Lung NSC(55;0.094)|all_lung(88;0.125)				ATACGGAGGAGAAAATATTGA	0.507000													22	84					0	0	0.062417	0	0	
MAGI2	9863	broad.mit.edu	37	7	77797390	77797390	+	Silent	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr7:77797390G>A	uc003ugx.2	-	15	2693	c.2439C>T	c.(2437-2439)GCC>GCT	p.A813A	MAGI2_uc003ugy.2_Silent_p.A799A|MAGI2_uc010ldx.1_Silent_p.A406A	NM_012301	NP_036433	Q86UL8	MAGI2_HUMAN	membrane associated guanylate kinase, WW and PDZ	813	PDZ 4.					cell junction|synapse|synaptosome	phosphatase binding			ovary(5)|lung(4)|breast(1)|skin(1)	11		all_cancers(73;0.0064)|all_epithelial(88;0.087)|all_neural(109;0.0936)|Medulloblastoma(109;0.166)|Melanoma(862;0.236)				CATCTCTGTCGGCTGAGCCCA	0.453000													27	87					0	0	0.108266	0	0	
SEMA3E	9723	broad.mit.edu	37	7	82997332	82997332	+	Missense_Mutation	SNP	A	G	G			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr7:82997332A>G	uc003uhy.1	-	17	2364	c.1898T>C	c.(1897-1899)GTT>GCT	p.V633A		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	633	Ig-like C2-type.				axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				GTCCATCTTAACCACTCTGTC	0.418000													16	76					0	0	0.160694	0	0	
CYP51A1	1595	broad.mit.edu	37	7	91743061	91743061	+	Missense_Mutation	SNP	C	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr7:91743061C>A	uc003ulm.3	-	10	1610	c.1448G>T	c.(1447-1449)GGA>GTA	p.G483V	CYP51A1_uc011khn.1_Missense_Mutation_p.G378V|CYP51A1_uc003uln.3_Missense_Mutation_p.G420V	NM_000786	NP_000777	Q16850	CP51A_HUMAN	cytochrome P450, family 51, subfamily A,	477					cholesterol biosynthetic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	electron carrier activity|heme binding|sterol 14-demethylase activity				0	all_cancers(62;2.16e-09)|all_epithelial(64;3.86e-08)|Breast(17;0.00206)|all_lung(186;0.169)|all_hematologic(106;0.215)|Lung NSC(181;0.227)		STAD - Stomach adenocarcinoma(171;6.16e-05)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)		Fluconazole(DB00196)|Itraconazole(DB01167)|Ketoconazole(DB01026)|Miconazole(DB01110)|Terconazole(DB00251)	GGGAAAGTATCCATCAATGAG	0.368000													21	77					1.50039e-11	1.70396e-11	0.062417	1	0	
FLNC	2318	broad.mit.edu	37	7	128478750	128478750	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr7:128478750C>T	uc003vnz.3	+	8	1513	c.1304C>T	c.(1303-1305)ACG>ATG	p.T435M	FLNC_uc003voa.3_Missense_Mutation_p.T435M	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	435	Filamin 2.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						GGTGACAGCACGTTCCGCTGC	0.657000													9	127					0	0	0.047766	0	0	
TRIM24	8805	broad.mit.edu	37	7	138265374	138265374	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr7:138265374C>T	uc003vuc.2	+	16	2868	c.2653C>T	c.(2653-2655)CCC>TCC	p.P885S	TRIM24_uc003vub.2_Missense_Mutation_p.P851S	NM_015905	NP_056989	O15164	TIF1A_HUMAN	transcriptional intermediary factor 1 alpha	885					cellular response to estrogen stimulus|protein catabolic process|regulation of apoptosis|regulation of protein stability|transcription from RNA polymerase II promoter	cytoplasm	chromatin binding|estrogen response element binding|histone acetyl-lysine binding|p53 binding|transcription coactivator activity|ubiquitin-protein ligase activity|zinc ion binding			central_nervous_system(3)|ovary(2)|stomach(1)|breast(1)|skin(1)	8						TTGTGATGCTCCCAGTCACAA	0.368000													37	112					0	0	0.064281	0	0	
MKRN1	23608	broad.mit.edu	37	7	140171773	140171773	+	Missense_Mutation	SNP	C	G	G			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr7:140171773C>G	uc003vvt.2	-	2	449	c.224G>C	c.(223-225)TGT>TCT	p.C75S	MKRN1_uc003vvs.2_Missense_Mutation_p.C11S|MKRN1_uc011krd.1_5'UTR|MKRN1_uc003vvv.3_Missense_Mutation_p.C75S|MKRN1_uc003vvu.3_Missense_Mutation_p.C11S	NM_013446	NP_038474	Q9UHC7	MKRN1_HUMAN	makorin ring finger protein 1 isoform 1	75	C3H1-type 1.						ligase activity|nucleic acid binding|protein binding|zinc ion binding			ovary(1)	1	Melanoma(164;0.00956)					CGAGTAGCGACAGTTGTCTCC	0.403000													16	67					0	0	0.146539	0	0	
CNTNAP2	26047	broad.mit.edu	37	7	146471365	146471365	+	Missense_Mutation	SNP	A	G	G			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr7:146471365A>G	uc003weu.1	+	2	616	c.100A>G	c.(100-102)AAA>GAA	p.K34E		NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	34	Extracellular (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GTTTTCAGAAAAATGTGATGA	0.428000										HNSCC(39;0.1)			4	18					0	0	0.150653	0	0	
SGK223	157285	broad.mit.edu	37	8	8185863	8185863	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr8:8185863G>A	uc003wsh.3	-	4	2429	c.2429C>T	c.(2428-2430)CCC>CTC	p.P810L		NM_001080826	NP_001074295	Q86YV5	SG223_HUMAN	pragmin	810							ATP binding|non-membrane spanning protein tyrosine kinase activity				0						GAGTGGAGGGGGCTGCTGGGG	0.637000													14	66					0	0	0.105934	0	0	
ESCO2	157570	broad.mit.edu	37	8	27634042	27634042	+	Nonsense_Mutation	SNP	C	T	T	rs141222001		TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr8:27634042C>T	uc003xgg.2	+	3	300	c.217C>T	c.(217-219)CAA>TAA	p.Q73*	ESCO2_uc010luy.1_RNA|ESCO2_uc003xgh.2_Nonsense_Mutation_p.Q73*	NM_001017420	NP_001017420	Q56NI9	ESCO2_HUMAN	establishment of cohesion 1 homolog 2	73					cell cycle|post-translational protein acetylation|regulation of DNA replication	chromatin|nucleus	acyltransferase activity|metal ion binding			central_nervous_system(1)	1		Ovarian(32;0.000953)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0204)|KIRC - Kidney renal clear cell carcinoma(542;0.0955)|Kidney(114;0.115)|Colorectal(74;0.132)		ATCAGCAAATCAAGGCTCACC	0.378000									SC_Phocomelia_syndrome				9	45					0	0	0.058154	0	0	
ADAM9	8754	broad.mit.edu	37	8	38874807	38874807	+	Silent	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr8:38874807C>T	uc003xmr.2	+	6	558	c.480C>T	c.(478-480)CAC>CAT	p.H160H	ADAM9_uc011lcf.1_RNA|ADAM9_uc011lcg.1_RNA|ADAM9_uc010lwr.2_RNA	NM_003816	NP_003807	Q13443	ADAM9_HUMAN	ADAM metallopeptidase domain 9 isoform 1	160	Extracellular (Potential).				activation of MAPKK activity|cell-cell adhesion mediated by integrin|cell-matrix adhesion|keratinocyte differentiation|monocyte activation|PMA-inducible membrane protein ectodomain proteolysis|PMA-inducible membrane protein ectodomain proteolysis|positive regulation of cell adhesion mediated by integrin|positive regulation of keratinocyte migration|positive regulation of macrophage fusion|positive regulation of membrane protein ectodomain proteolysis|positive regulation of protein secretion|response to calcium ion|response to glucocorticoid stimulus|response to hydrogen peroxide|response to manganese ion|response to tumor necrosis factor|transforming growth factor beta receptor signaling pathway	extracellular space|extracellular space|integral to membrane|intrinsic to external side of plasma membrane	collagen binding|integrin binding|laminin binding|metalloendopeptidase activity|protein kinase C binding|SH3 domain binding|zinc ion binding			ovary(1)|central_nervous_system(1)	2		all_lung(54;0.00292)|Lung NSC(58;0.0115)|Hepatocellular(245;0.0153)	LUSC - Lung squamous cell carcinoma(45;2.74e-07)			ATTTTGAGCACATCATTTATC	0.398000													13	63					0	0	0.105934	0	0	
MYST3	7994	broad.mit.edu	37	8	41798853	41798853	+	Missense_Mutation	SNP	T	C	C			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr8:41798853T>C	uc010lxb.2	-	16	3090	c.2546A>G	c.(2545-2547)CAA>CGA	p.Q849R	MYST3_uc010lxc.2_Missense_Mutation_p.Q849R|MYST3_uc003xon.3_Missense_Mutation_p.Q849R	NM_001099412	NP_001092882	Q92794	MYST3_HUMAN	MYST histone acetyltransferase (monocytic	849					histone H3 acetylation|myeloid cell differentiation|negative regulation of transcription, DNA-dependent|nucleosome assembly|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	MOZ/MORF histone acetyltransferase complex|nucleosome	DNA binding|histone acetyltransferase activity|transcription coactivator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7	all_epithelial(6;1.12e-27)|all_lung(13;3.94e-12)|Lung NSC(13;6.54e-11)|Ovarian(28;0.00744)|Prostate(17;0.0119)|Colorectal(14;0.0221)|Lung SC(25;0.211)	all_lung(54;0.000294)|Lung NSC(58;0.00105)|Hepatocellular(245;0.0524)|Esophageal squamous(32;0.0954)|Renal(179;0.0983)	Epithelial(1;2.82e-19)|all cancers(1;1.15e-16)|BRCA - Breast invasive adenocarcinoma(8;9.17e-11)|OV - Ovarian serous cystadenocarcinoma(14;9.4e-05)|Colorectal(10;0.000728)|Lung(22;0.00153)|LUSC - Lung squamous cell carcinoma(45;0.00741)|COAD - Colon adenocarcinoma(11;0.0171)			AGGAAGGACTTGTTTGCTCAA	0.443000													14	62					0	0	0.105934	0	0	
KCNB2	9312	broad.mit.edu	37	8	73849089	73849089	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr8:73849089C>T	uc003xzb.2	+	3	2087	c.1499C>T	c.(1498-1500)TCG>TTG	p.S500L		NM_004770	NP_004761	Q92953	KCNB2_HUMAN	potassium voltage-gated channel, Shab-related	500	Cytoplasmic (Potential).				regulation of smooth muscle contraction	voltage-gated potassium channel complex	delayed rectifier potassium channel activity|protein binding			skin(3)|large_intestine(1)|pancreas(1)|ovary(1)|central_nervous_system(1)	7	Breast(64;0.137)		Epithelial(68;0.105)			AAGGCTCTGTCGGAAACAAGC	0.557000													23	121					0	0	0.069288	0	0	
STAU2	27067	broad.mit.edu	37	8	74526145	74526145	+	Missense_Mutation	SNP	C	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr8:74526145C>A	uc003xzm.2	-	9	961	c.725G>T	c.(724-726)CGA>CTA	p.R242L	STAU2_uc011lfg.1_Missense_Mutation_p.R70L|STAU2_uc003xzn.2_Missense_Mutation_p.R210L|STAU2_uc011lfh.1_Missense_Mutation_p.R138L|STAU2_uc003xzo.2_Missense_Mutation_p.R242L|STAU2_uc003xzp.2_Missense_Mutation_p.R210L|STAU2_uc011lfi.1_Missense_Mutation_p.R204L|STAU2_uc003xzq.2_Missense_Mutation_p.R22L|STAU2_uc010lzk.2_Missense_Mutation_p.R210L|STAU2_uc010lzl.1_Missense_Mutation_p.R70L	NM_014393	NP_055208	Q9NUL3	STAU2_HUMAN	staufen homolog 2 isoform e	242	DRBM 3.				transport	endoplasmic reticulum|microtubule|nucleolus	double-stranded RNA binding				0	Breast(64;0.0138)		Epithelial(68;0.026)|BRCA - Breast invasive adenocarcinoma(89;0.0483)|all cancers(69;0.0972)			TACTGACACTCGAGTAACAAA	0.378000													10	29					9.31168e-06	9.88e-06	0.105934	1	0	
ZFHX4	79776	broad.mit.edu	37	8	77690554	77690554	+	Silent	SNP	G	C	C			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr8:77690554G>C	uc003yav.2	+	4	3513	c.3126G>C	c.(3124-3126)TCG>TCC	p.S1042S	ZFHX4_uc003yau.1_Silent_p.S1068S|ZFHX4_uc003yaw.1_Silent_p.S1042S	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1042	C2H2-type 7.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			ATGTCCGTTCGGTGAAGCATC	0.512000										HNSCC(33;0.089)			13	168					0	0	0.093190	0	0	
CSMD3	114788	broad.mit.edu	37	8	113318256	113318256	+	Missense_Mutation	SNP	T	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr8:113318256T>A	uc003ynu.2	-	51	8210	c.8051A>T	c.(8050-8052)AAC>ATC	p.N2684I	CSMD3_uc003yns.2_Missense_Mutation_p.N1886I|CSMD3_uc003ynt.2_Missense_Mutation_p.N2644I|CSMD3_uc011lhx.1_Missense_Mutation_p.N2580I	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2684	Extracellular (Potential).|Sushi 15.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AGGGGTCTTGTTATGATTGCT	0.363000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			37	135					0	0	0.092188	0	0	
CSMD3	114788	broad.mit.edu	37	8	113348959	113348959	+	Missense_Mutation	SNP	C	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr8:113348959C>A	uc003ynu.2	-	44	7100	c.6941G>T	c.(6940-6942)AGA>ATA	p.R2314I	CSMD3_uc003yns.2_Missense_Mutation_p.R1516I|CSMD3_uc003ynt.2_Missense_Mutation_p.R2274I|CSMD3_uc011lhx.1_Missense_Mutation_p.R2210I|CSMD3_uc003ynw.1_Missense_Mutation_p.R25I	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2314	Extracellular (Potential).|CUB 13.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AGGGGGTACTCTTACAAGCCA	0.373000										HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			22	115					6.44725e-10	7.24915e-10	0.069288	1	0	
POU5F1B	5462	broad.mit.edu	37	8	128428897	128428897	+	Silent	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr8:128428897C>T	uc003ysf.2	+	1	1041	c.786C>T	c.(784-786)ATC>ATT	p.I262I	uc003ysc.1_Intron|uc003ysd.1_Intron|LOC727677_uc003yse.1_Intron|uc011liu.1_5'Flank	NM_001159542	NP_001153014	Q06416	P5F1B_HUMAN	POU class 5 homeobox 1B	262	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0						TCAGCCACATCGCCCAGCAGC	0.567000													3	11					0	0	0.115264	0	0	
JAK2	3717	broad.mit.edu	37	9	5069141	5069141	+	Silent	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr9:5069141G>A	uc010mhm.2	+	10	1559	c.1446G>A	c.(1444-1446)CAG>CAA	p.Q482Q	JAK2_uc003ziw.2_Silent_p.Q482Q	NM_004972	NP_004963	O60674	JAK2_HUMAN	Janus kinase 2	482	SH2; atypical.				actin filament polymerization|activation of caspase activity by protein phosphorylation|activation of JAK2 kinase activity|blood coagulation|cellular component movement|erythrocyte differentiation|interferon-gamma-mediated signaling pathway|interleukin-12-mediated signaling pathway|JAK-STAT cascade involved in growth hormone signaling pathway|mammary gland epithelium development|mesoderm development|negative regulation of cell proliferation|negative regulation of DNA binding|positive regulation of apoptosis|positive regulation of cell-substrate adhesion|positive regulation of growth hormone receptor signaling pathway|positive regulation of nitric-oxide synthase 2 biosynthetic process|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of tumor necrosis factor production|positive regulation of tyrosine phosphorylation of Stat3 protein|positive regulation of tyrosine phosphorylation of Stat5 protein|protein autophosphorylation|regulation of inflammatory response|regulation of interferon-gamma-mediated signaling pathway|response to antibiotic|response to lipopolysaccharide|STAT protein import into nucleus|tumor necrosis factor-mediated signaling pathway|tyrosine phosphorylation of STAT protein	caveola|cytoskeleton|cytosol|endomembrane system|nucleus	ATP binding|growth hormone receptor binding|heme binding|histone binding|histone kinase activity (H3-Y41 specific)|interleukin-12 receptor binding|non-membrane spanning protein tyrosine kinase activity|protein kinase binding|SH2 domain binding		PCM1/JAK2(30)|PAX5/JAK2(18)|ETV6/JAK2(11)|BCR/JAK2(6)|SSBP2/JAK2(4)|SEC31A/JAK2(4)	haematopoietic_and_lymphoid_tissue(28629)|lung(5)|breast(5)|ovary(1)|liver(1)	28641	all_hematologic(13;0.137)	Acute lymphoblastic leukemia(23;0.0198)|Breast(48;0.147)		GBM - Glioblastoma multiforme(50;0.0237)|Lung(218;0.133)		ATTGTTACCAGATGGAAACTG	0.323000		1	T|Mis|O	ETV6|PCM1|BCR	ALL|AML|MPD| CML				Polycythemia_Vera_Familial				12	53					0	0	0.080935	0	0	
IFNA10	3446	broad.mit.edu	37	9	21206570	21206570	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr9:21206570G>A	uc003zoq.1	-	1	573	c.527C>T	c.(526-528)TCG>TTG	p.S176L	IFNA14_uc003zoo.1_Intron	NM_002171	NP_002162	P01566	IFN10_HUMAN	interferon, alpha 10 precursor	176					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding				0				Lung(24;1.26e-23)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.17)		TGTTGAAAACGAGAGGGATCT	0.388000													25	355					0	0	0.108266	0	0	
IFNA6	3443	broad.mit.edu	37	9	21350353	21350353	+	Silent	SNP	T	C	C			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr9:21350353T>C	uc011lni.1	-	1	534	c.534A>G	c.(532-534)TCA>TCG	p.S178S		NM_021002	NP_066282	P05013	IFNA6_HUMAN	interferon, alpha 6 precursor	178					blood coagulation|regulation of type I interferon-mediated signaling pathway|response to virus|type I interferon-mediated signaling pathway	extracellular space	cytokine activity|cytokine receptor binding				0				Lung(24;7.66e-27)|LUSC - Lung squamous cell carcinoma(38;1.4e-13)|OV - Ovarian serous cystadenocarcinoma(39;0.116)		GCAAGTTTCTTGATGAAGAGA	0.438000													67	259					0	0	0.139131	0	0	
HNRNPK	3190	broad.mit.edu	37	9	86585140	86585140	+	Missense_Mutation	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr9:86585140C>T	uc004ang.3	-	16	1522	c.1298G>A	c.(1297-1299)CGG>CAG	p.R433Q	HNRNPK_uc011lsw.1_Missense_Mutation_p.R193Q|HNRNPK_uc004and.3_Missense_Mutation_p.R193Q|HNRNPK_uc004ank.3_Missense_Mutation_p.R432Q|HNRNPK_uc004anf.3_Missense_Mutation_p.R433Q|HNRNPK_uc004anh.3_Missense_Mutation_p.R409Q|HNRNPK_uc011lsx.1_Missense_Mutation_p.R409Q|HNRNPK_uc004ani.3_Missense_Mutation_p.R432Q|HNRNPK_uc004anj.3_Missense_Mutation_p.R432Q|HNRNPK_uc004ann.3_Missense_Mutation_p.R408Q|HNRNPK_uc004anl.3_Missense_Mutation_p.R433Q|HNRNPK_uc004anm.3_Missense_Mutation_p.R433Q|uc004ano.1_5'Flank|MIR7-1_hsa-mir-7-1|MI0000263_5'Flank	NM_031262	NP_112552	P61978	HNRPK_HUMAN	heterogeneous nuclear ribonucleoprotein K	433	KH 3.				interspecies interaction between organisms|positive regulation of low-density lipoprotein particle receptor biosynthetic process|positive regulation of receptor-mediated endocytosis|regulation of lipid transport by positive regulation of transcription from an RNA polymerase II promoter|regulation of low-density lipoprotein particle clearance|signal transduction	catalytic step 2 spliceosome|cytoplasm|heterogeneous nuclear ribonucleoprotein complex|nuclear chromatin|nucleoplasm	protein binding|RNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|single-stranded DNA binding			skin(1)	1						GGTAATGATCCGATCTTCGGA	0.413000													18	71					0	0	0.175082	0	0	
Unknown	0	broad.mit.edu	37	9	99884567	99884567	+	RNA	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr9:99884567G>A	uc004aww.1	-	2		c.1227C>T								Homo sapiens cDNA FLJ34611 fis, clone KIDNE2014112.																		GAGACAAAACGCATTTTCCTT	0.463000													14	65					0	0	0.119110	0	0	
ZNF79	7633	broad.mit.edu	37	9	130206660	130206660	+	Silent	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr9:130206660G>A	uc004bqw.3	+	5	1095	c.681G>A	c.(679-681)GGG>GGA	p.G227G	ZNF79_uc011maf.1_Silent_p.G203G|ZNF79_uc011mag.1_Silent_p.G203G	NM_007135	NP_009066	Q15937	ZNF79_HUMAN	zinc finger protein 79	227	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1						GTGAATGTGGGAAGGCCTTCA	0.493000													20	84					0	0	0.043863	0	0	
BAT2L1	84726	broad.mit.edu	37	9	134321941	134321941	+	Missense_Mutation	SNP	G	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr9:134321941G>A	uc004can.3	+	6	822	c.767G>A	c.(766-768)CGC>CAC	p.R256H	BAT2L1_uc010mzj.1_5'Flank|BAT2L1_uc004cam.1_Missense_Mutation_p.R256H	NM_013318	NP_037450	Q5JSZ5	PRC2B_HUMAN	HLA-B associated transcript 2-like	256							protein binding				0						CCCTCTCTCCGCCCGGCTCAG	0.562000													6	31					0	0	0.038147	0	0	
IL1RAPL1	11141	broad.mit.edu	37	X	28807512	28807512	+	Missense_Mutation	SNP	A	G	G			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chrX:28807512A>G	uc004dby.2	+	2	560	c.52A>G	c.(52-54)AGT>GGT	p.S18G		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	18					innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						TTTTACTCAGAGTTTGAAGGT	0.378000													16	27					0	0	0.146539	0	0	
WNK3	65267	broad.mit.edu	37	X	54263436	54263436	+	Missense_Mutation	SNP	G	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chrX:54263436G>T	uc004dtd.1	-	20	4861	c.4422C>A	c.(4420-4422)AGC>AGA	p.S1474R	WNK3_uc004dtc.1_Missense_Mutation_p.S1521R	NM_001002838	NP_001002838	Q9BYP7	WNK3_HUMAN	WNK lysine deficient protein kinase 3 isoform 2	1474					intracellular protein kinase cascade|positive regulation of establishment of protein localization in plasma membrane|positive regulation of peptidyl-threonine phosphorylation|positive regulation of rubidium ion transmembrane transporter activity|positive regulation of rubidium ion transport|positive regulation of sodium ion transmembrane transporter activity|positive regulation of sodium ion transport|protein autophosphorylation	adherens junction|tight junction	ATP binding|protein binding|protein serine/threonine kinase activity|rubidium ion transmembrane transporter activity|sodium ion transmembrane transporter activity			lung(4)|ovary(3)|kidney(2)|central_nervous_system(2)	11						CATCATCACTGCTCATTGGGG	0.423000													53	86					1.77205e-36	2.13023e-36	0.139131	1	0	
ZXDA	7789	broad.mit.edu	37	X	57934628	57934628	+	Missense_Mutation	SNP	T	G	G			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chrX:57934628T>G	uc004dve.2	-	1	2440	c.2227A>C	c.(2227-2229)AGT>CGT	p.S743R		NM_007156	NP_009087	P98168	ZXDA_HUMAN	zinc finger, X-linked, duplicated A	743					positive regulation of transcription, DNA-dependent	nucleus	C2H2 zinc finger domain binding|identical protein binding|nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						TCTGAGACACTGTTTTCACAA	0.498000													22	31					0	0	0.055883	0	0	
KLHL4	56062	broad.mit.edu	37	X	86880644	86880644	+	Missense_Mutation	SNP	C	A	A			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chrX:86880644C>A	uc004efb.2	+	6	1354	c.1172C>A	c.(1171-1173)ACT>AAT	p.T391N	KLHL4_uc004efa.2_Missense_Mutation_p.T391N	NM_019117	NP_061990	Q9C0H6	KLHL4_HUMAN	kelch-like 4 isoform 1	391						cytoplasm|microtubule cytoskeleton|nucleolus	actin binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5						TCCATGTTTACTGGTGATCTT	0.408000													20	16					4.96729e-08	5.47613e-08	0.049695	1	0	
CT47B1	643311	broad.mit.edu	37	X	120008811	120008811	+	Silent	SNP	C	T	T			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chrX:120008811C>T	uc011muc.1	-	1	969	c.714G>A	c.(712-714)GAG>GAA	p.E238E		NM_001145718	NP_001139190	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 147, member B1	238											0						ctgtggcctcctctgtgagct	0.552000													45	62					0	0	0.117977	0	0	
CD40LG	959	broad.mit.edu	37	X	135741443	135741443	+	Missense_Mutation	SNP	G	A	A	rs148594123	byFrequency	TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chrX:135741443G>A	uc004faa.2	+	5	727	c.655G>A	c.(655-657)GGG>AGG	p.G219R	CD40LG_uc010nsd.2_Missense_Mutation_p.G198R	NM_000074	NP_000065	P29965	CD40L_HUMAN	CD40 ligand	219	Extracellular (Potential).		G -> R.		anti-apoptosis|B cell proliferation|inflammatory response|isotype switching|leukocyte cell-cell adhesion|platelet activation|positive regulation of endothelial cell apoptosis|positive regulation of interleukin-12 production	extracellular space|integral to plasma membrane|soluble fraction	CD40 receptor binding|cytokine activity|tumor necrosis factor receptor binding			skin(1)	1	Acute lymphoblastic leukemia(192;0.000127)				Atorvastatin(DB01076)	CAAACCTTGCGGGCAACAATC	0.498000									Immune_Deficiency_with_Hyper-IgM				10	170					0	0	0.080935	0	0	
Unknown	0	broad.mit.edu	37	1	4014714	4014714	+	RNA	DEL	C	-	-			TCGA-D7-8572-01A-11D-2340-08	TCGA-D7-8572-10A-01D-2341-08									Somatic	Phase_I	Capture				Illumina GAIIx	584e46d6-280d-4aaa-b03e-5fd7ece08d77	a0e40acf-0a3e-4b8d-b504-22a3001b1191	g.chr1:4014714delC	uc001ali.1	+	3		c.2634delC								Homo sapiens cDNA FLJ42718 fis, clone BRAMY3010411.																		GTTTCCTCTTCGTTGCTTTTC	0.552													2	4	---	---	---	---						.
