Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
IRF2BP1	26145	broad.mit.edu	37	19	46388153	46388153	+	Missense_Mutation	SNP	G	G	A			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr19:46388153G>A	ENST00000302165.3	-	1	1223	c.880C>T	c.(880-882)Cgc>Tgc	p.R294C		NM_015649.1	NP_056464.1	Q8IU81	I2BP1_HUMAN	interferon regulatory factor 2 binding protein 1	294					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				cervix(1)|kidney(1)|lung(2)	4		all_neural(266;0.113)|Ovarian(192;0.127)		OV - Ovarian serous cystadenocarcinoma(262;0.00442)|GBM - Glioblastoma multiforme(486;0.0402)|Epithelial(262;0.231)		AACATCTGGCGAGCCACTGCC	0.592000													5	167					0	0	1	0	0
ZNF750	79755	broad.mit.edu	37	17	80788321	80788321	+	Silent	SNP	C	C	T			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr17:80788321C>T	ENST00000269394.3	-	3	2702	c.1869G>A	c.(1867-1869)gcG>gcA	p.A623A	TBCD_ENST00000539345.2_Intron|TBCD_ENST00000397466.2_Intron|TBCD_ENST00000355528.4_Intron|ZNF750_ENST00000572562.1_Silent_p.A224A	NM_024702.2	NP_078978.2	Q32MQ0	ZN750_HUMAN	zinc finger protein 750	623						intracellular	zinc ion binding			NS(3)|breast(2)|central_nervous_system(1)|cervix(1)|endometrium(4)|large_intestine(4)|lung(12)|prostate(1)|skin(1)|upper_aerodigestive_tract(2)	31	Breast(20;0.000523)|all_neural(118;0.0779)	all_cancers(8;0.0514)|all_epithelial(8;0.0748)	OV - Ovarian serous cystadenocarcinoma(97;0.0868)|BRCA - Breast invasive adenocarcinoma(99;0.149)			TGCTGTCCACCGCGCATGCGT	0.711000													17	58					0	0	1	0	0
SDK2	54549	broad.mit.edu	37	17	71344825	71344825	+	Silent	SNP	C	C	G	rs150319493	byFrequency	TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr17:71344825C>G	ENST00000392650.3	-	44	6078	c.6078G>C	c.(6076-6078)tcG>tcC	p.S2026S	SDK2_ENST00000410094.1_5'UTR|SDK2_ENST00000388726.3_Silent_p.S2007S	NM_001144952.1	NP_001138424.1	Q58EX2	SDK2_HUMAN	sidekick cell adhesion molecule 2	2026					cell adhesion	integral to membrane				breast(4)|central_nervous_system(2)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(15)|lung(31)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	86						CATCCTCATCCGAGTAGTGCA	0.642000													4	56					0	0	1	0	0
SLC9C2	284525	broad.mit.edu	37	1	173506126	173506126	+	Missense_Mutation	SNP	C	C	A			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr1:173506126C>A	ENST00000367714.3	-	14	2032	c.1610G>T	c.(1609-1611)cGg>cTg	p.R537L	SLC9C2_ENST00000536496.1_Missense_Mutation_p.R435L|SLC9C2_ENST00000466087.1_5'UTR	NM_178527.3	NP_848622.2	Q5TAH2	S9A11_HUMAN	solute carrier family 9, member C2 (putative)	537					sodium ion transport	integral to membrane	ion channel activity|solute:hydrogen antiporter activity										AATTAATATCCGGGCTGCCTC	0.308000													24	132					6.32553e-13	7.18211e-13	1	1	0
PRLR	5618	broad.mit.edu	37	5	35084594	35084594	+	Silent	SNP	A	A	C			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr5:35084594A>C	ENST00000382002.5	-	5	777	c.351T>G	c.(349-351)ctT>ctG	p.L117L	PRLR_ENST00000231423.3_Silent_p.L117L|PRLR_ENST00000348262.3_Silent_p.L117L|PRLR_ENST00000310101.5_Silent_p.L117L|PRLR_ENST00000397391.3_Silent_p.L46L|PRLR_ENST00000513753.1_Silent_p.L117L|PRLR_ENST00000542609.1_Silent_p.L117L|PRLR_ENST00000511486.1_Intron|PRLR_ENST00000342362.5_Intron|PRLR_ENST00000509934.1_5'UTR	NM_000949.5	NP_000940.1	P16471	PRLR_HUMAN	prolactin receptor	117	Fibronectin type-III 1.				activation of JAK2 kinase activity|activation of transmembrane receptor protein tyrosine kinase activity|anti-apoptosis|embryo implantation|lactation|steroid biosynthetic process|T cell activation	cell surface|extracellular region|integral to membrane	metal ion binding|ornithine decarboxylase activator activity|peptide hormone binding|prolactin receptor activity|protein homodimerization activity			central_nervous_system(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(5)|lung(29)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(2)	48	all_lung(31;3.83e-05)		COAD - Colon adenocarcinoma(61;0.174)|Colorectal(62;0.229)		Dromostanolone(DB00858)|Fluoxymesterone(DB01185)|Pegvisomant(DB00082)|Somatropin recombinant(DB00052)	CGTCCACATAAAGTTCATCCG	0.453000													4	190					0	0	1	0	0
C5orf38	153571	broad.mit.edu	37	5	2752842	2752842	+	Missense_Mutation	SNP	G	G	T			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr5:2752842G>T	ENST00000515640.1	+	2	326	c.307G>T	c.(307-309)Gcg>Tcg	p.A103S	C5orf38_ENST00000505778.1_Missense_Mutation_p.A103S|C5orf38_ENST00000457752.2_Intron|C5orf38_ENST00000334000.3_Missense_Mutation_p.A103S|C5orf38_ENST00000397835.4_Missense_Mutation_p.A103S|IRX2_ENST00000502957.1_5'UTR			Q86SI9	CEI_HUMAN	chromosome 5 open reading frame 38	103						extracellular region				endometrium(2)|large_intestine(1)|lung(1)	4				GBM - Glioblastoma multiforme(108;0.205)		GCTCAGGTTGGCGCCGCCGGT	0.637000													58	63					1.64591e-14	1.88847e-14	1	1	0
SLC5A8	160728	broad.mit.edu	37	12	101561910	101561910	+	Silent	SNP	G	G	A			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr12:101561910G>A	ENST00000536262.2	-	11	1842	c.1284C>T	c.(1282-1284)ttC>ttT	p.F428F		NM_145913.3	NP_666018.3	Q8N695	SC5A8_HUMAN	solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8	428					apoptosis|sodium ion transport	apical plasma membrane|integral to membrane	monocarboxylic acid transmembrane transporter activity|passive transmembrane transporter activity|symporter activity			breast(1)|endometrium(3)|kidney(1)|large_intestine(9)|lung(29)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	47						TGCCCAAAGCGAACAGGCCCA	0.398000													4	16					0	0	1	0	0
ZNF174	7727	broad.mit.edu	37	16	3452156	3452156	+	Missense_Mutation	SNP	G	G	A			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr16:3452156G>A	ENST00000268655.4	+	1	737	c.152G>A	c.(151-153)cGc>cAc	p.R51H	ZNF174_ENST00000575752.1_Missense_Mutation_p.R51H|ZNF174_ENST00000571936.1_Missense_Mutation_p.R51H|ZNF174_ENST00000344823.5_Missense_Mutation_p.R51H|ZNF174_ENST00000572544.1_Missense_Mutation_p.R51H|LA16c-306E5.2_ENST00000575785.1_RNA	NM_003450.2	NP_003441.1	Q15697	ZN174_HUMAN	zinc finger protein 174	51					negative regulation of transcription from RNA polymerase II promoter|viral reproduction	actin cytoskeleton|cytoplasm|nucleus	protein homodimerization activity|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			endometrium(2)|large_intestine(3)|lung(3)|prostate(2)|urinary_tract(2)	12						AGCTTCAGACGCTTTTGTTAT	0.547000													8	388					0	0	1	0	0
TBX2	6909	broad.mit.edu	37	17	59485535	59485535	+	Missense_Mutation	SNP	G	G	A			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr17:59485535G>A	ENST00000240328.3	+	7	2088	c.1807G>A	c.(1807-1809)Gcc>Acc	p.A603T	RP11-332H18.4_ENST00000592009.1_RNA	NM_005994.3	NP_005985.3	Q13207	TBX2_HUMAN	T-box 2	603	Ala-rich.				cell aging|positive regulation of cell proliferation		sequence-specific DNA binding			endometrium(1)|lung(7)|ovary(1)	9						cgccgcagccgccgGCTCCCT	0.701000													5	59					0	0	1	0	0
FCGBP	8857	broad.mit.edu	37	19	40411752	40411752	+	Silent	SNP	G	G	A			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr19:40411752G>A	ENST00000221347.6	-	7	3883	c.3876C>T	c.(3874-3876)gcC>gcT	p.A1292A		NM_003890.2	NP_003881.2	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein	1292	VWFD 3.					extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CCTGCAGGACGGCAAACCGAT	0.632000													75	137					0	0	1	0	0
TMX4	56255	broad.mit.edu	37	20	7963214	7963214	+	Missense_Mutation	SNP	T	T	C			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr20:7963214T>C	ENST00000246024.2	-	8	949	c.734A>G	c.(733-735)gAg>gGg	p.E245G		NM_021156.2	NP_066979.2	Q9H1E5	TMX4_HUMAN	thioredoxin-related transmembrane protein 4	245	Glu-rich.				cell redox homeostasis|electron transport chain|transport	integral to membrane				endometrium(3)|large_intestine(2)|lung(11)|skin(1)	17						tttttcctcctcCGCATCCTG	0.423000													9	25					0	0	1	0	0
MT-CYB	4519	broad.mit.edu	37	MT	15617	15617	+	Missense_Mutation	SNP	G	G	A			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chrM:15617G>A	ENST00000361789.2	+	1	871	c.871G>A	c.(871-873)Gtc>Atc	p.291_291insI						mitochondrially encoded cytochrome b											breast(6)|endometrium(25)|kidney(33)|prostate(1)	65						AACTAGGAGGCGTCCTTGCCC	0.468000											OREG0007583	type=REGULATORY REGION|TFbs=ESR1|Dataset=Estrogen Receptor Alpha Binding Sites|EvidenceSubtype=Chromatin immunoprecipitation with tag sequencing (ChIP-TS)	4	170					0	0	1	0	0
ABCB9	23457	broad.mit.edu	37	12	123435080	123435080	+	Missense_Mutation	SNP	C	C	A			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr12:123435080C>A	ENST00000542678.1	-	3	3472	c.634G>T	c.(634-636)Gcc>Tcc	p.A212S	ABCB9_ENST00000346530.5_Missense_Mutation_p.A212S|ABCB9_ENST00000442028.2_Missense_Mutation_p.A212S|ABCB9_ENST00000344275.7_Missense_Mutation_p.A212S|ABCB9_ENST00000540285.1_Missense_Mutation_p.A212S|ABCB9_ENST00000280560.8_Missense_Mutation_p.A212S|ABCB9_ENST00000392439.3_Missense_Mutation_p.A212S|ABCB9_ENST00000442833.2_Missense_Mutation_p.A212S			Q9NP78	ABCB9_HUMAN	ATP-binding cassette, sub-family B (MDR/TAP), member 9	212	ABC transmembrane type-1.				positive regulation of T cell mediated cytotoxicity|protein transport	lysosomal membrane|plasma membrane|TAP complex	ATP binding|MHC class I protein binding|oligopeptide-transporting ATPase activity|peptide antigen binding|protein homodimerization activity|TAP1 binding|TAP2 binding|tapasin binding	p.A212T(1)		central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(9)|ovary(2)|prostate(1)|skin(1)	18	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;6.84e-05)|Epithelial(86;0.000152)|BRCA - Breast invasive adenocarcinoma(302;0.111)		CCATCAATGGCGCGGCCCGTG	0.632000													3	45					0.115264	0.117418	1	1	0
URGCP	55665	broad.mit.edu	37	7	43918018	43918018	+	Missense_Mutation	SNP	A	A	C			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr7:43918018A>C	ENST00000336086.6	-	4	3151	c.915T>G	c.(913-915)ttT>ttG	p.F305L	URGCP_ENST00000497914.1_5'UTR|URGCP_ENST00000443736.1_Missense_Mutation_p.F305L|URGCP_ENST00000402306.3_Missense_Mutation_p.F339L|URGCP_ENST00000447717.3_Missense_Mutation_p.F305L|RP5-1165K10.1_ENST00000603700.1_Intron|URGCP_ENST00000453200.1_Missense_Mutation_p.F348L|URGCP_ENST00000223341.7_Missense_Mutation_p.F305L			Q8TCY9	URGCP_HUMAN	upregulator of cell proliferation	348					cell cycle	centrosome|nucleus	GTP binding			breast(3)|endometrium(4)|kidney(2)|large_intestine(3)|liver(1)|lung(13)|ovary(2)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	34						TCAAGAGCTTAAACTGCAGCC	0.463000													48	65					0	0	1	0	0
CASR	846	broad.mit.edu	37	3	122003445	122003445	+	Missense_Mutation	SNP	A	A	C			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr3:122003445A>C	ENST00000498619.1	+	7	3112	c.2674A>C	c.(2674-2676)Aag>Cag	p.K892Q	CASR_ENST00000296154.5_Missense_Mutation_p.K882Q|CASR_ENST00000490131.1_Missense_Mutation_p.K882Q	NM_001178065.1	NP_001171536.1	P41180	CASR_HUMAN	calcium-sensing receptor	882	Interaction with RNF19A.				anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	TCACGCTTTCAAGGTGGCTGC	0.622000													28	37					0	0	1	0	0
ZNF267	10308	broad.mit.edu	37	16	31927691	31927691	+	Silent	SNP	G	G	T			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr16:31927691G>T	ENST00000300870.10	+	4	2330	c.2121G>T	c.(2119-2121)cgG>cgT	p.R707R	RP11-170L3.8_ENST00000575471.1_RNA	NM_001265588.1|NM_003414.5	NP_001252517.1|NP_003405.3	Q14586	ZN267_HUMAN	zinc finger protein 267	707					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(3)|endometrium(5)|kidney(1)|large_intestine(14)|lung(11)|ovary(2)|skin(3)|upper_aerodigestive_tract(2)	41						CTACACATCGGAGAAGTCATA	0.438000													25	17					1.1804e-14	1.36876e-14	1	1	0
UBA1	7317	broad.mit.edu	37	X	47074220	47074220	+	Silent	SNP	G	G	A			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chrX:47074220G>A	ENST00000335972.6	+	26	3252	c.3069G>A	c.(3067-3069)tcG>tcA	p.S1023S	UBA1_ENST00000377351.4_Silent_p.S1023S|UBA1_ENST00000377269.3_Silent_p.S471S	NM_003334.3	NP_003325.2	P22314	UBA1_HUMAN	ubiquitin-like modifier activating enzyme 1	1023					cell death|protein modification process		ATP binding|ligase activity|protein binding|small protein activating enzyme activity			breast(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(7)|ovary(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	31						GCCGTGTGTCGAAGCGAAAGC	0.602000													7	215					0	0	1	0	0
ARSK	153642	broad.mit.edu	37	5	94891003	94891003	+	Silent	SNP	G	G	C			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr5:94891003G>C	ENST00000380009.4	+	1	226	c.21G>C	c.(19-21)tcG>tcC	p.S7S	ARSK_ENST00000504763.1_Silent_p.S7S	NM_198150.2	NP_937793.1	Q6UWY0	ARSK_HUMAN	arylsulfatase family, member K	7						extracellular region	arylsulfatase activity|metal ion binding			endometrium(2)|kidney(1)|large_intestine(3)|lung(8)|pancreas(1)|skin(1)	16		all_cancers(142;3.38e-06)|all_epithelial(76;6.57e-09)|all_lung(232;0.00307)|Lung NSC(167;0.00452)|Ovarian(225;0.00473)		all cancers(79;6.5e-16)		TGTGGGTGTCGGTGGTCGCAG	0.692000													3	11					0	0	1	0	0
PTPRZ1	5803	broad.mit.edu	37	7	121652768	121652768	+	Missense_Mutation	SNP	A	A	G			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr7:121652768A>G	ENST00000393386.2	+	12	4079	c.3668A>G	c.(3667-3669)cAt>cGt	p.H1223R	PTPRZ1_ENST00000449182.1_Intron|PTPRZ1_ENST00000483028.1_Intron	NM_001206838.1|NM_002851.2	NP_001193767.1|NP_002842.2	P23471	PTPRZ_HUMAN	protein tyrosine phosphatase, receptor-type, Z polypeptide 1	1223					central nervous system development	integral to plasma membrane	protein binding|protein tyrosine/threonine phosphatase activity|transmembrane receptor protein tyrosine phosphatase activity			NS(1)|breast(3)|central_nervous_system(4)|cervix(1)|endometrium(4)|kidney(12)|large_intestine(17)|liver(1)|lung(42)|ovary(4)|prostate(5)|skin(8)|upper_aerodigestive_tract(2)|urinary_tract(2)	106						ACAATGTTGCATCTCATTGTA	0.398000													5	140					0	0	1	0	0
ADIPOR1	51094	broad.mit.edu	37	1	202915580	202915580	+	Nonsense_Mutation	SNP	C	C	T			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr1:202915580C>T	ENST00000340990.5	-	4	715	c.417G>A	c.(415-417)tgG>tgA	p.W139*	ADIPOR1_ENST00000367254.3_Nonsense_Mutation_p.W139*|ADIPOR1_ENST00000436244.1_Nonsense_Mutation_p.W139*	NM_015999.4	NP_057083.2	Q96A54	ADR1_HUMAN	adiponectin receptor 1	139					fatty acid oxidation|hormone-mediated signaling pathway	integral to membrane|plasma membrane	hormone binding|protein kinase binding|receptor activity			breast(1)|central_nervous_system(1)|endometrium(2)|large_intestine(2)|lung(7)|prostate(2)|skin(1)	16			BRCA - Breast invasive adenocarcinoma(75;0.141)			GCAGATGGGTCCAGATGTTGC	0.478000													34	145					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628282	29628282	+	Missense_Mutation	SNP	G	G	A			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr20:29628282G>A	ENST00000278882.3	+	6	664	c.284G>A	c.(283-285)gGg>gAg	p.G95E	FRG1B_ENST00000439954.2_Missense_Mutation_p.G100E|FRG1B_ENST00000358464.4_Missense_Mutation_p.G95E																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						AATGAAGCAGGGGACATAGAA	0.373000													4	81					0	0	1	0	0
OR51T1	401665	broad.mit.edu	37	11	4903359	4903359	+	Missense_Mutation	SNP	T	T	C			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr11:4903359T>C	ENST00000380378.1	+	1	311	c.311T>C	c.(310-312)aTt>aCt	p.I104T	MMP26_ENST00000380390.1_Intron|MMP26_ENST00000477339.1_Intron|OR51T1_ENST00000322049.1_Missense_Mutation_p.I77T	NM_001004759.1	NP_001004759.1	Q8NGJ9	O51T1_HUMAN	olfactory receptor, family 51, subfamily T, member 1	77					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|endometrium(4)|kidney(2)|large_intestine(5)|lung(16)|ovary(2)|skin(3)|upper_aerodigestive_tract(1)	34		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGTCTGACCATTACGACCCTT	0.443000													20	20					0	0	1	0	0
C16orf90	646174	broad.mit.edu	37	16	3543946	3543946	+	Nonsense_Mutation	SNP	G	G	A			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr16:3543946G>A	ENST00000437192.3	-	3	444	c.442C>T	c.(442-444)Cag>Tag	p.Q148*	LA16c-306E5.3_ENST00000574423.2_RNA	NM_001080524.1	NP_001073993.1	A8MZG2	CP090_HUMAN	chromosome 16 open reading frame 90	138										large_intestine(1)	1						GGACTAGGCTGGGGGAGGGCA	0.627000													6	13					0	0	1	0	0
PPP1R3A	5506	broad.mit.edu	37	7	113518383	113518383	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr7:113518383C>T	ENST00000284601.3	-	4	2832	c.2764G>A	c.(2764-2766)Gaa>Aaa	p.E922K		NM_002711.3	NP_002702.2	Q16821	PPR3A_HUMAN	protein phosphatase 1, regulatory subunit 3A	922					glycogen metabolic process	integral to membrane				NS(2)|breast(8)|cervix(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(14)|liver(1)|lung(43)|ovary(10)|pancreas(7)|prostate(3)|skin(15)|stomach(1)|upper_aerodigestive_tract(2)	121						ACTGAAATTTCAGTATGATGT	0.378000													41	71					0	0	1	0	0
DFNB31	25861	broad.mit.edu	37	9	117240804	117240804	+	Missense_Mutation	SNP	G	G	T			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr9:117240804G>T	ENST00000374057.3	-	2	1514	c.866C>A	c.(865-867)cCt>cAt	p.P289H	DFNB31_ENST00000362057.3_Intron|DFNB31_ENST00000265134.6_Intron			Q9P202	WHRN_HUMAN	deafness, autosomal recessive 31	289	PDZ 2.				inner ear receptor stereocilium organization|retina homeostasis|sensory perception of light stimulus|sensory perception of sound	cytoplasm|growth cone|stereocilium				central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(9)|liver(1)|lung(14)|ovary(5)|pancreas(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	38						GTGTCTGAGAGGCTGGCCTCC	0.612000													16	2					4.14922e-12	4.61495e-12	1	1	0
KNTC1	9735	broad.mit.edu	37	12	123075167	123075167	+	Missense_Mutation	SNP	G	G	A			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr12:123075167G>A	ENST00000333479.7	+	41	4190	c.4013G>A	c.(4012-4014)cGc>cAc	p.R1338H	KNTC1_ENST00000450485.2_Intron	NM_014708.4	NP_055523.1	P50748	KNTC1_HUMAN	kinetochore associated 1	1338					cell division|mitotic cell cycle checkpoint|mitotic prometaphase|protein complex assembly|regulation of exit from mitosis	condensed chromosome kinetochore|cytosol|kinetochore microtubule|nucleus|spindle pole	protein binding			breast(1)|central_nervous_system(1)|cervix(2)|endometrium(12)|kidney(8)|large_intestine(12)|lung(20)|ovary(7)|prostate(1)|skin(1)|upper_aerodigestive_tract(3)|urinary_tract(4)	72	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;7.21e-05)|Epithelial(86;0.000178)|BRCA - Breast invasive adenocarcinoma(302;0.217)		TTTAATTGTCGCTTGGTAGAT	0.368000													5	124					0	0	1	0	0
F9	2158	broad.mit.edu	37	X	138642950	138642950	+	Missense_Mutation	SNP	T	T	G			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chrX:138642950T>G	ENST00000218099.2	+	7	781	c.774T>G	c.(772-774)aaT>aaG	p.N258K	F9_ENST00000394090.2_Missense_Mutation_p.N220K	NM_000133.3	NP_000124.1	P00740	FA9_HUMAN	coagulation factor IX	258	Peptidase S1.				blood coagulation, extrinsic pathway|blood coagulation, intrinsic pathway|peptidyl-glutamic acid carboxylation|post-translational protein modification|proteolysis	endoplasmic reticulum lumen|extracellular region|Golgi lumen|plasma membrane	calcium ion binding|serine-type endopeptidase activity			breast(1)|central_nervous_system(2)|endometrium(4)|large_intestine(7)|lung(19)|ovary(1)|skin(1)	35	Acute lymphoblastic leukemia(192;0.000127)				Antihemophilic Factor(DB00025)|Coagulation Factor IX(DB00100)|Heparin(DB01109)|Menadione(DB00170)	CTATCGTTAATGAAAAATGGA	0.353000													4	108					0	0	1	0	0
ZNF711	7552	broad.mit.edu	37	X	84526455	84526455	+	Missense_Mutation	SNP	A	A	T			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chrX:84526455A>T	ENST00000360700.4	+	10	2931	c.2045A>T	c.(2044-2046)aAg>aTg	p.K682M	ZNF711_ENST00000373165.3_Missense_Mutation_p.K636M|ZNF711_ENST00000276123.3_Missense_Mutation_p.K636M|ZNF711_ENST00000395402.1_Missense_Mutation_p.K644M|ZNF711_ENST00000542798.1_Missense_Mutation_p.K478M			Q9Y462	ZN711_HUMAN	zinc finger protein 711	636				RCK -> GCT (in Ref. 4; CAA39837).	positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(2)|liver(1)|lung(14)|ovary(3)|skin(4)	28						GAGCTCAAAAAGCATAGTGAT	0.403000													7	45					0	0	1	0	0
TULP4	56995	broad.mit.edu	37	6	158923248	158923248	+	Silent	SNP	G	G	C			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr6:158923248G>C	ENST00000367097.3	+	13	3910	c.2553G>C	c.(2551-2553)ccG>ccC	p.P851P	TULP4_ENST00000367094.2_Intron	NM_020245.4	NP_064630.2	Q9NRJ4	TULP4_HUMAN	tubby like protein 4	851					intracellular signal transduction|response to nutrient	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity			endometrium(7)|kidney(2)|large_intestine(15)|lung(17)|ovary(1)|pancreas(1)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	49		Breast(66;0.000781)|Ovarian(120;0.0308)|Lung SC(201;0.164)|Prostate(117;0.171)		OV - Ovarian serous cystadenocarcinoma(65;1.64e-18)|BRCA - Breast invasive adenocarcinoma(81;2.67e-05)		CAGCACCCCCGCCCCCTCTGC	0.657000													5	17					0	0	1	0	0
DAAM1	23002	broad.mit.edu	37	14	59826213	59826213	+	Missense_Mutation	SNP	C	C	A			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr14:59826213C>A	ENST00000395125.1	+	21	2677	c.2654C>A	c.(2653-2655)gCg>gAg	p.A885E	DAAM1_ENST00000553966.1_3'UTR|DAAM1_ENST00000360909.3_Missense_Mutation_p.A875E|DAAM1_ENST00000351081.1_Missense_Mutation_p.A885E	NM_014992.2	NP_055807.1	Q9Y4D1	DAAM1_HUMAN	dishevelled associated activator of morphogenesis 1	885	FH2.				actin cytoskeleton organization	cytoplasm|plasma membrane	actin binding|Rho GTPase binding			breast(3)|cervix(3)|endometrium(5)|kidney(5)|large_intestine(4)|lung(7)|ovary(2)|prostate(1)|skin(2)|upper_aerodigestive_tract(4)|urinary_tract(1)	37				OV - Ovarian serous cystadenocarcinoma(108;0.165)		CCTCAAGCTGCGAAAGTAAAG	0.378000													6	13					3.59834e-05	3.92219e-05	1	1	0
NTRK1	4914	broad.mit.edu	37	1	156843598	156843598	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr1:156843598C>T	ENST00000368196.3	+	8	1144	c.1024C>T	c.(1024-1026)Cgg>Tgg	p.R342W	NTRK1_ENST00000524377.1_Missense_Mutation_p.R342W|NTRK1_ENST00000392302.2_Missense_Mutation_p.R312W|NTRK1_ENST00000358660.3_Missense_Mutation_p.R342W	NM_001012331.1	NP_001012331.1	P04629	NTRK1_HUMAN	neurotrophic tyrosine kinase, receptor, type 1	342	Ig-like C2-type 2.				activation of adenylate cyclase activity|activation of MAPKK activity|activation of phospholipase C activity|cell differentiation|nerve growth factor receptor signaling pathway|nervous system development|phosphatidylinositol-mediated signaling|Ras protein signal transduction	endosome|integral to plasma membrane	ATP binding|neurotrophin receptor activity|transmembrane receptor protein serine/threonine kinase activity|transmembrane receptor protein tyrosine kinase activity			breast(3)|central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(7)|lung(35)|ovary(8)|prostate(2)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(3)	74	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)				Imatinib(DB00619)	TGAGACCGTGCGGCACGGGTG	0.632000			T	"""TPM3, TPR, TFG"""	papillary thyroid					TSP Lung(10;0.080)			23	17					0	0	1	0	0
CACNA1S	779	broad.mit.edu	37	1	201047049	201047049	+	Missense_Mutation	SNP	A	A	G			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr1:201047049A>G	ENST00000362061.3	-	11	1803	c.1577T>C	c.(1576-1578)gTg>gCg	p.V526A	CACNA1S_ENST00000367338.3_Missense_Mutation_p.V526A	NM_000069.2	NP_000060.2	Q13698	CAC1S_HUMAN	calcium channel, voltage-dependent, L type, alpha 1S subunit	526					axon guidance	I band|T-tubule|voltage-gated calcium channel complex	high voltage-gated calcium channel activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(19)|lung(37)|ovary(6)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	102					Magnesium Sulfate(DB00653)|Verapamil(DB00661)	GCAGCGGAGCACGGAGATGCC	0.627000													5	91					0	0	1	0	0
MAGEB2	4113	broad.mit.edu	37	X	30236701	30236701	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chrX:30236701C>T	ENST00000378988.4	+	2	105	c.4C>T	c.(4-6)Cct>Tct	p.P2S		NM_002364.4	NP_002355.2	O15479	MAGB2_HUMAN	melanoma antigen family B, 2	2							protein binding			breast(1)|large_intestine(3)|lung(17)|ovary(1)|skin(1)	23						AGCCATCATGCCTCGTGGTCA	0.527000													6	38					0	0	1	0	0
ZNF814	730051	broad.mit.edu	37	19	58385546	58385546	+	Missense_Mutation	SNP	G	G	T			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr19:58385546G>T	ENST00000435989.2	-	3	1446	c.1212C>A	c.(1210-1212)gaC>gaA	p.D404E	ZNF814_ENST00000597342.1_Intron|ZNF814_ENST00000595295.1_Intron|ZNF814_ENST00000596604.1_Intron|ZNF814_ENST00000597832.1_Intron|ZNF814_ENST00000600634.1_Intron	NM_001144989.1	NP_001138461.1	B7Z6K7	ZN814_HUMAN	zinc finger protein 814	404					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding	p.D404E(10)		NS(1)|central_nervous_system(2)|endometrium(3)|kidney(9)|lung(2)|prostate(4)|skin(1)|urinary_tract(3)	25						AATGTTTTTTGTCAGTGTGAA	0.393000													3	15					2.56e-06	2.81859e-06	1	1	0
PITPNM2	57605	broad.mit.edu	37	12	123494604	123494604	+	Missense_Mutation	SNP	C	C	A			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr12:123494604C>A	ENST00000280562.5	-	5	641	c.436G>T	c.(436-438)Gac>Tac	p.D146Y	PITPNM2_ENST00000546049.1_Missense_Mutation_p.D146Y|PITPNM2_ENST00000392428.1_Intron|PITPNM2_ENST00000320201.4_Missense_Mutation_p.D146Y|PITPNM2_ENST00000451868.2_5'UTR|PITPNM2_ENST00000542749.1_Missense_Mutation_p.D146Y			Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein, membrane-associated 2	146					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			NS(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(8)|lung(10)|ovary(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)	39	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		GGCACAGGGTCTTTGACAATG	0.567000													62	54					7.92265e-33	9.48976e-33	1	1	0
ZNF280B	140883	broad.mit.edu	37	22	22842866	22842866	+	Silent	SNP	A	A	G			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr22:22842866A>G	ENST00000360412.2	-	4	1633	c.858T>C	c.(856-858)agT>agC	p.S286S	ZNF280B_ENST00000406426.1_Silent_p.S286S	NM_080764.2	NP_542942.1	Q86YH2	Z280B_HUMAN	zinc finger protein 280B	286					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			autonomic_ganglia(1)|endometrium(2)|kidney(1)|large_intestine(6)|liver(1)|lung(9)|ovary(2)	22	all_hematologic(9;0.0135)|Acute lymphoblastic leukemia(84;0.17)	all_hematologic(6;1.74e-30)|Acute lymphoblastic leukemia(6;7.75e-22)		READ - Rectum adenocarcinoma(21;0.145)		AGTAAAAGTCACTAAGTAACA	0.383000													4	81					0	0	1	0	0
DOCK5	80005	broad.mit.edu	37	8	25258522	25258522	+	Missense_Mutation	SNP	G	G	T			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr8:25258522G>T	ENST00000276440.7	+	47	4910	c.4866G>T	c.(4864-4866)ttG>ttT	p.L1622F		NM_024940.6	NP_079216.4	Q9H7D0	DOCK5_HUMAN	dedicator of cytokinesis 5	1622	DHR-2.					cytoplasm	GTP binding|GTPase binding|guanyl-nucleotide exchange factor activity			NS(1)|breast(4)|central_nervous_system(1)|endometrium(12)|kidney(9)|large_intestine(13)|lung(20)|ovary(3)|prostate(1)|skin(4)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	72		all_cancers(63;0.0361)|Ovarian(32;0.000711)|all_epithelial(46;0.0153)|Hepatocellular(4;0.115)|Prostate(55;0.13)|Breast(100;0.143)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0267)|Epithelial(17;1.07e-11)|Colorectal(74;0.0276)|COAD - Colon adenocarcinoma(73;0.0828)		ATGAGCGGTTGTCTTCTTGCT	0.483000													6	140					0.00116845	0.00124863	1	1	0
MT-ND1	4535	broad.mit.edu	37	MT	3745	3745	+	Missense_Mutation	SNP	G	G	A			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chrM:3745G>A	ENST00000361390.2	+	1	439	c.439G>A	c.(439-441)Gcc>Acc	p.147_147insT						mitochondrially encoded NADH dehydrogenase 1											breast(1)|endometrium(13)|kidney(17)|lung(2)|prostate(1)	34						AAGTCACCCTAGCCATCATTC	0.453000													19	163					0	0	1	0	0
ANO4	121601	broad.mit.edu	37	12	101295429	101295429	+	Missense_Mutation	SNP	A	A	C			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr12:101295429A>C	ENST00000538618.1	+	4	364	c.364A>C	c.(364-366)Agt>Cgt	p.S122R	ANO4_ENST00000392977.3_5'UTR|ANO4_ENST00000299222.9_5'UTR|ANO4_ENST00000392979.3_5'UTR|ANO4_ENST00000551148.1_3'UTR			Q32M45	ANO4_HUMAN	anoctamin 4	0						chloride channel complex	chloride channel activity			NS(1)|biliary_tract(1)|breast(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(14)|lung(33)|ovary(4)|prostate(5)|skin(7)|stomach(2)|urinary_tract(1)	78						TCCAGGTTTAAGTTTATCTAT	0.488000										HNSCC(74;0.22)			6	47					0	0	1	0	0
LRRC36	55282	broad.mit.edu	37	16	67400946	67400946	+	Missense_Mutation	SNP	T	T	C			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr16:67400946T>C	ENST00000329956.6	+	8	800	c.781T>C	c.(781-783)Tcc>Ccc	p.S261P	LRRC36_ENST00000541146.1_Intron|LRRC36_ENST00000435835.3_Missense_Mutation_p.S140P|LRRC36_ENST00000563189.1_Missense_Mutation_p.S140P|LRRC36_ENST00000290940.7_5'UTR	NM_018296.5	NP_060766.5	Q1X8D7	LRC36_HUMAN	leucine rich repeat containing 36	261										endometrium(4)|kidney(2)|large_intestine(5)|lung(4)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	24		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0669)|Epithelial(162;0.161)		GCCTCGTCAGTCCACAGTCCG	0.433000													5	102					0	0	1	0	0
IQGAP1	8826	broad.mit.edu	37	15	90931626	90931626	+	Missense_Mutation	SNP	G	G	A			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr15:90931626G>A	ENST00000268182.5	+	1	177	c.53G>A	c.(52-54)gGc>gAc	p.G18D	IQGAP1_ENST00000560738.1_Missense_Mutation_p.G18D	NM_003870.3	NP_003861.1	P46940	IQGA1_HUMAN	IQ motif containing GTPase activating protein 1	18					energy reserve metabolic process|regulation of insulin secretion|small GTPase mediated signal transduction	actin filament|cytoplasm|midbody|nucleus|plasma membrane	calmodulin binding|GTPase inhibitor activity|protein phosphatase binding|Ras GTPase activator activity			breast(2)|central_nervous_system(3)|endometrium(4)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(14)|liver(1)|lung(18)|ovary(2)|pancreas(1)|prostate(3)|skin(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	59	Melanoma(11;0.00551)|Lung NSC(78;0.0237)|all_lung(78;0.0488)		BRCA - Breast invasive adenocarcinoma(143;0.0745)|KIRC - Kidney renal clear cell carcinoma(17;0.138)|Kidney(142;0.194)			CCGCACTATGGCTGTGAGTGC	0.716000													4	9					0	0	1	0	0
INPP5F	22876	broad.mit.edu	37	10	121586918	121586918	+	Missense_Mutation	SNP	T	T	A	rs140846782		TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr10:121586918T>A	ENST00000361976.2	+	20	3191	c.3025T>A	c.(3025-3027)Tct>Act	p.S1009T	INPP5F_ENST00000369080.3_Missense_Mutation_p.S399T	NM_014937.3	NP_055752.1	Q9Y2H2	SAC2_HUMAN	inositol polyphosphate-5-phosphatase F	1009							phosphoric ester hydrolase activity			breast(1)|cervix(1)|endometrium(7)|kidney(4)|large_intestine(9)|lung(5)|ovary(5)|pancreas(1)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(1)|urinary_tract(3)	42		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.00205)|BRCA - Breast invasive adenocarcinoma(275;0.158)		ACAGACACCTTCTCGGCCATC	0.453000													32	68					0	0	1	0	0
ATP4A	495	broad.mit.edu	37	19	36047934	36047934	+	Missense_Mutation	SNP	C	C	G			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr19:36047934C>G	ENST00000262623.3	-	12	1778	c.1750G>C	c.(1750-1752)Gta>Cta	p.V584L		NM_000704.2	NP_000695.2	P20648	ATP4A_HUMAN	ATPase, H+/K+ exchanging, alpha polypeptide	584					ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			breast(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(12)|lung(26)|ovary(2)|prostate(2)|upper_aerodigestive_tract(1)	53	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	ATGGCCTCTACGTCGAAGGCA	0.592000													41	149					0	0	1	0	0
CRB1	23418	broad.mit.edu	37	1	197411423	197411423	+	Splice_Site	SNP	G	G	T			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr1:197411423G>T	ENST00000367400.3	+	11	4140		c.e11+1		RP11-75C23.1_ENST00000422250.1_RNA|CRB1_ENST00000544212.1_Splice_Site|CRB1_ENST00000538660.1_Splice_Site|CRB1_ENST00000367399.2_Splice_Site|CRB1_ENST00000535699.1_Splice_Site|CRB1_ENST00000367397.1_3'UTR	NM_201253.2	NP_957705.1	P82279	CRUM1_HUMAN	crumbs homolog 1 (Drosophila)						cell-cell signaling|establishment or maintenance of cell polarity	apical plasma membrane|extracellular region|integral to membrane	calcium ion binding|protein binding			NS(1)|breast(4)|central_nervous_system(2)|cervix(3)|endometrium(13)|kidney(4)|large_intestine(21)|lung(58)|ovary(7)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(2)	132						CGAGGTGGACGTAAGCAGCCT	0.478000													9	196					0.000274275	0.000296	1	1	0
TRPM6	140803	broad.mit.edu	37	9	77377523	77377523	+	Missense_Mutation	SNP	G	G	C			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr9:77377523G>C	ENST00000451710.3	-	26	4301	c.4064C>G	c.(4063-4065)cCt>cGt	p.P1355R	TRPM6_ENST00000449912.2_Missense_Mutation_p.P1350R|TRPM6_ENST00000360774.1_Missense_Mutation_p.P1355R|TRPM6_ENST00000376864.4_Missense_Mutation_p.P1355R|TRPM6_ENST00000361255.3_Missense_Mutation_p.P1350R|TRPM6_ENST00000376871.3_Intron|TRPM6_ENST00000376872.3_Intron			Q9BX84	TRPM6_HUMAN	transient receptor potential cation channel, subfamily M, member 6	1355					response to toxin	integral to membrane	ATP binding|calcium channel activity|metal ion binding|protein binding|protein serine/threonine kinase activity			NS(2)|breast(1)|central_nervous_system(1)|cervix(1)|endometrium(13)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(22)|liver(1)|lung(53)|ovary(1)|prostate(7)|skin(12)|stomach(4)|upper_aerodigestive_tract(2)|urinary_tract(1)	126						TGCTGAAAAAGGAACTCGCTT	0.478000													6	144					0	0	1	0	0
FCN3	8547	broad.mit.edu	37	1	27697155	27697155	+	Missense_Mutation	SNP	G	G	T			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr1:27697155G>T	ENST00000270879.4	-	7	595	c.590C>A	c.(589-591)aCc>aAc	p.T197N	FCN3_ENST00000354982.2_Missense_Mutation_p.T186N	NM_003665.2	NP_003656.2	O75636	FCN3_HUMAN	ficolin (collagen/fibrinogen domain containing) 3	197	Fibrinogen C-terminal.				complement activation, lectin pathway|signal transduction	collagen|extracellular space	receptor binding|sugar binding			endometrium(2)|kidney(2)|large_intestine(1)|lung(1)|urinary_tract(1)	7		all_lung(284;1.6e-05)|Lung NSC(340;2.92e-05)|Colorectal(325;3.46e-05)|Renal(390;0.0007)|Breast(348;0.0021)|Ovarian(437;0.0175)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0381)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0415)|OV - Ovarian serous cystadenocarcinoma(117;1.42e-27)|Colorectal(126;1.24e-08)|COAD - Colon adenocarcinoma(152;1.7e-06)|BRCA - Breast invasive adenocarcinoma(304;0.00128)|KIRC - Kidney renal clear cell carcinoma(1967;0.00155)|STAD - Stomach adenocarcinoma(196;0.00303)|READ - Rectum adenocarcinoma(331;0.0419)		GAGGCGGAAGGTCGCATAGTG	0.577000													5	120					0.0215528	0.0221627	1	1	0
CHIAP2	0	broad.mit.edu	37	1	111825692	111825692	+	RNA	SNP	C	C	T			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr1:111825692C>T	ENST00000369743.4	+	0	1237					NR_003928.1																						GCATCTCCAACATCCAGTCTG	0.507000													7	14					0	0	1	0	0
ILKAP	80895	broad.mit.edu	37	2	239103471	239103471	+	Silent	SNP	G	G	A			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr2:239103471G>A	ENST00000254654.3	-	2	271	c.96C>T	c.(94-96)ctC>ctT	p.L32L	ILKAP_ENST00000490837.1_5'UTR	NM_030768.2	NP_110395.1	Q9H0C8	ILKAP_HUMAN	integrin-linked kinase-associated serine/threonine phosphatase	32						cytoplasm|protein serine/threonine phosphatase complex	metal ion binding|protein binding			endometrium(1)|kidney(3)|large_intestine(5)|lung(4)|ovary(3)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	19		Breast(86;7.61e-05)|Renal(207;0.00183)|Ovarian(221;0.0481)|all_lung(227;0.152)|all_hematologic(139;0.158)|Melanoma(123;0.203)|Hepatocellular(293;0.244)		Epithelial(121;5.49e-24)|OV - Ovarian serous cystadenocarcinoma(60;3.93e-12)|Kidney(56;3.04e-09)|KIRC - Kidney renal clear cell carcinoma(57;6.82e-08)|BRCA - Breast invasive adenocarcinoma(100;0.00012)|Lung(119;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0163)		TGGCCGGAGGGAGGTCATCAA	0.473000													13	39					0	0	1	0	0
ZNF282	8427	broad.mit.edu	37	7	148895722	148895722	+	Missense_Mutation	SNP	G	G	T			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr7:148895722G>T	ENST00000262085.3	+	2	568	c.463G>T	c.(463-465)Ggg>Tgg	p.G155W	ZNF282_ENST00000479907.1_Missense_Mutation_p.G155W	NM_003575.2	NP_003566.1	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	155					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(3)|large_intestine(3)|lung(7)|prostate(2)|skin(1)|urinary_tract(1)	17	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		GGCCGTGCTGGGGACCCTGCT	0.647000													5	185					0.014758	0.0154675	1	1	0
RNF151	146310	broad.mit.edu	37	16	2018541	2018541	+	Missense_Mutation	SNP	G	G	T			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr16:2018541G>T	ENST00000569714.1	+	4	361	c.353G>T	c.(352-354)tGc>tTc	p.C118F	RNF151_ENST00000321392.3_Missense_Mutation_p.C117F|RNF151_ENST00000569210.2_3'UTR	NM_174903.4	NP_777563.2	Q2KHN1	RN151_HUMAN	ring finger protein 151	118					cell differentiation|spermatogenesis	cytoplasm|nucleus	ubiquitin-protein ligase activity|zinc ion binding			kidney(1)|lung(1)	2						AACGAGGGCTGCACCTCGCAG	0.697000													3	19					0.004672	0.00494416	1	1	0
TANGO2	128989	broad.mit.edu	37	22	20024591	20024591	+	Silent	SNP	A	A	G			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr22:20024591A>G	ENST00000456048.1	+	1	45	c.45A>G	c.(43-45)gaA>gaG	p.E15E	TANGO2_ENST00000398042.2_Intron|TANGO2_ENST00000327374.4_Intron|TANGO2_ENST00000401833.1_Silent_p.E51E|TANGO2_ENST00000401886.1_Intron|TANGO2_ENST00000447208.2_Intron|TANGO2_ENST00000434570.2_Silent_p.E51E|TANGO2_ENST00000432883.1_Intron|TANGO2_ENST00000479679.1_Intron|TANGO2_ENST00000420290.2_Intron					transport and golgi organization 2 homolog (Drosophila)																		AAAGACGTGAAGACTCAGCCA	0.602000													4	124					0	0	1	0	0
ZFYVE16	9765	broad.mit.edu	37	5	79734554	79734554	+	Missense_Mutation	SNP	G	G	A			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr5:79734554G>A	ENST00000338008.5	+	3	2230	c.2050G>A	c.(2050-2052)Gtt>Att	p.V684I	ZFYVE16_ENST00000505560.1_Missense_Mutation_p.V684I|ZFYVE16_ENST00000510158.1_Missense_Mutation_p.V684I	NM_014733.3	NP_055548.3	Q7Z3T8	ZFY16_HUMAN	zinc finger, FYVE domain containing 16	684					BMP signaling pathway|endosome transport|protein targeting to lysosome|regulation of endocytosis|vesicle organization	early endosome membrane	1-phosphatidylinositol binding|metal ion binding|phosphatidylinositol-3,4,5-trisphosphate binding|protein binding|protein transporter activity			breast(4)|cervix(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(4)|kidney(5)|large_intestine(14)|liver(1)|lung(6)|ovary(2)|prostate(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	51		Lung NSC(167;0.00428)|all_lung(232;0.00455)|Ovarian(174;0.0261)		OV - Ovarian serous cystadenocarcinoma(54;1.6e-46)|Epithelial(54;2.02e-41)|all cancers(79;5.05e-36)		AGCAGATACCGTTGTTCCAAT	0.398000													11	77					0	0	1	0	0
FIG4	9896	broad.mit.edu	37	6	110081456	110081456	+	Missense_Mutation	SNP	C	C	G			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr6:110081456C>G	ENST00000230124.3	+	11	1265	c.1141C>G	c.(1141-1143)Cga>Gga	p.R381G	FIG4_ENST00000441478.2_Missense_Mutation_p.R104G	NM_014845.5	NP_055660.1	Q92562	FIG4_HUMAN	FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)	381	SAC.				cell death	endosome membrane	protein binding			central_nervous_system(2)|cervix(1)|endometrium(4)|kidney(4)|large_intestine(3)|lung(14)|ovary(2)|prostate(2)	32		all_cancers(87;8.63e-07)|Acute lymphoblastic leukemia(125;2.66e-08)|all_hematologic(75;1.13e-06)|all_epithelial(87;0.000124)|all_lung(197;0.0187)|Colorectal(196;0.0492)|Lung SC(18;0.0548)		OV - Ovarian serous cystadenocarcinoma(136;0.0355)|Epithelial(106;0.038)|all cancers(137;0.0425)|BRCA - Breast invasive adenocarcinoma(108;0.079)		GATAAAGGAACGAGAGAAAAG	0.333000													11	44					0	0	1	0	0
GALNT2	2590	broad.mit.edu	37	1	230415077	230415077	+	Missense_Mutation	SNP	A	A	C			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr1:230415077A>C	ENST00000366672.4	+	16	1661	c.1589A>C	c.(1588-1590)aAg>aCg	p.K530T	GALNT2_ENST00000543760.1_Missense_Mutation_p.K492T|GALNT2_ENST00000485438.1_3'UTR	NM_004481.3	NP_004472.1	Q10471	GALT2_HUMAN	UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2 (GalNAc-T2)	530	Ricin B-type lectin.				immunoglobulin biosynthetic process|protein O-linked glycosylation via serine|protein O-linked glycosylation via threonine	extracellular region|Golgi cisterna membrane|integral to Golgi membrane|perinuclear region of cytoplasm	manganese ion binding|polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			breast(2)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(6)|lung(10)|ovary(2)|prostate(5)|skin(2)	32	Breast(184;0.193)|Ovarian(103;0.249)	all_cancers(173;0.156)|Prostate(94;0.179)				GGCAACTCCAAGCTGAGGCAC	0.582000													33	40					0	0	1	0	0
DMRT3	58524	broad.mit.edu	37	9	990202	990202	+	Missense_Mutation	SNP	G	G	A			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr9:990202G>A	ENST00000190165.2	+	2	654	c.616G>A	c.(616-618)Gct>Act	p.A206T		NM_021240.2	NP_067063.1	Q9NQL9	DMRT3_HUMAN	doublesex and mab-3 related transcription factor 3	206					cell differentiation|multicellular organismal development|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity	p.A206T(1)|p.A69T(1)		NS(1)|breast(1)|central_nervous_system(2)|endometrium(1)|large_intestine(5)|lung(11)|ovary(2)|skin(2)|upper_aerodigestive_tract(1)	26		all_lung(10;1.39e-08)|Lung NSC(10;1.42e-08)		Lung(218;0.0196)		AGGGGGATACGCTGTCCAGAA	0.597000													12	109					0	0	1	0	0
CTD-2049J23.2	0	broad.mit.edu	37	3	159818733	159818733	+	RNA	SNP	C	C	T			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr3:159818733C>T	ENST00000497452.1	-	0	517																											TAGGAGGGAACGAAGTCACCG	0.507000													9	134					0	0	1	0	0
TTC30B	150737	broad.mit.edu	37	2	178416032	178416032	+	Missense_Mutation	SNP	T	T	C			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr2:178416032T>C	ENST00000408939.2	-	1	1710	c.1460A>G	c.(1459-1461)aAg>aGg	p.K487R		NM_152517.2	NP_689730.2	Q8N4P2	TT30B_HUMAN	tetratricopeptide repeat domain 30B	487					cell projection organization	cilium	binding			cervix(1)|endometrium(1)|kidney(4)|large_intestine(7)|lung(6)|prostate(1)|skin(2)|urinary_tract(1)	23			OV - Ovarian serous cystadenocarcinoma(117;0.00151)|Epithelial(96;0.00931)|all cancers(119;0.0362)			ATAATGCTTCTTGACTATGGG	0.383000													23	84					0	0	1	0	0
CTD-2207O23.3	0	broad.mit.edu	37	19	7516088	7516088	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr19:7516088C>T	ENST00000593531.1	+	9	1100	c.1100C>T	c.(1099-1101)tCc>tTc	p.S367F	ARHGEF18_ENST00000319670.9_Silent_p.L251L|ARHGEF18_ENST00000359920.6_Silent_p.L409L																							AGTGCATTCTCCTGGTTACAC	0.542000													16	14					0	0	1	0	0
SLC7A6	9057	broad.mit.edu	37	16	68308894	68308894	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr16:68308894C>T	ENST00000566454.1	+	4	534	c.265C>T	c.(265-267)Ctc>Ttc	p.L89F	SLC7A6_ENST00000219343.6_Missense_Mutation_p.L89F	NM_001076785.2	NP_001070253.1	Q92536	YLAT2_HUMAN	solute carrier family 7 (amino acid transporter light chain, y+L system), member 6	89					blood coagulation|cellular amino acid metabolic process|ion transport|leukocyte migration|protein complex assembly	basolateral plasma membrane|integral to plasma membrane	amino acid transmembrane transporter activity|antiporter activity			breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(3)|lung(4)|prostate(1)|skin(1)	16		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.034)|Epithelial(162;0.0948)		CATTGGTGGGCTCTTCTCTGT	0.552000													4	97					0	0	1	0	0
RPL12P38	0	broad.mit.edu	37	17	58512711	58512711	+	RNA	SNP	G	G	C			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr17:58512711G>C	ENST00000588627.1	-	0	646																											AGCAGGTTTAGCAGACAACCT	0.522000													4	30					0	0	1	0	0
PCDHGA7	0	broad.mit.edu	37	5	140764737	140764737	+	Silent	SNP	C	C	G			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr5:140764737C>G	ENST00000518325.1	+	1	2271	c.2271C>G	c.(2269-2271)gtC>gtG	p.V757V	PCDHGA4_ENST00000571252.1_Intron|PCDHGA5_ENST00000518069.1_Intron|PCDHGB1_ENST00000523390.1_Intron|PCDHGB2_ENST00000522605.1_Intron|PCDHGA3_ENST00000253812.6_Intron|PCDHGA6_ENST00000517434.1_Intron|PCDHGB3_ENST00000576222.1_Intron|PCDHGA1_ENST00000517417.1_Intron|PCDHGA2_ENST00000394576.2_Intron	NM_018920.2	NP_061743.1														NS(1)|biliary_tract(1)|endometrium(8)|kidney(4)|large_intestine(10)|lung(19)|ovary(1)|skin(1)|stomach(3)|urinary_tract(1)	49			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CCCATGAGGTCTCCCTCACCG	0.562000													90	33					0	0	1	0	0
MGAM	8972	broad.mit.edu	37	7	141736743	141736743	+	Nonsense_Mutation	SNP	C	C	T			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr7:141736743C>T	ENST00000475668.2	+	18	2251	c.2197C>T	c.(2197-2199)Cga>Tga	p.R733*	MGAM_ENST00000549489.2_Nonsense_Mutation_p.R733*			O43451	MGA_HUMAN	maltase-glucoamylase (alpha-glucosidase)	733	Maltase.				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			cervix(1)|endometrium(1)|large_intestine(4)|lung(3)|ovary(2)|skin(2)	13	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	TGCTCACAGCCGAGGGGACAC	0.468000													53	193					0	0	1	0	0
FAM5B	0	broad.mit.edu	37	1	177247778	177247778	+	Missense_Mutation	SNP	G	G	A			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr1:177247778G>A	ENST00000361539.4	+	7	1404	c.1092G>A	c.(1090-1092)atG>atA	p.M364I	FAM5B_ENST00000478325.1_3'UTR	NM_021165.2	NP_066988.1	Q9C0B6	FAM5B_HUMAN		364						extracellular region				breast(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(3)|kidney(4)|large_intestine(21)|liver(1)|lung(41)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(2)|urinary_tract(1)	94						TCTGGGCCATGGACACCAGCC	0.567000													15	579					0	0	1	0	0
MTUS2	23281	broad.mit.edu	37	13	29600313	29600313	+	Missense_Mutation	SNP	G	G	A			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr13:29600313G>A	ENST00000431530.3	+	1	1566	c.1508G>A	c.(1507-1509)cGc>cAc	p.R503H		NM_001033602.2	NP_001028774.2	Q5JR59	MTUS2_HUMAN	microtubule associated tumor suppressor candidate 2	493						cytoplasm|microtubule	microtubule binding|protein homodimerization activity			NS(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(6)|lung(3)|prostate(1)|skin(1)	20						CAAAGTGGCCGCTCAGAAGCA	0.498000													21	11					0	0	1	0	0
SYCP2	10388	broad.mit.edu	37	20	58489063	58489063	+	Missense_Mutation	SNP	T	T	C			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr20:58489063T>C	ENST00000357552.3	-	12	1022	c.797A>G	c.(796-798)aAc>aGc	p.N266S	SYCP2_ENST00000371001.2_Missense_Mutation_p.N266S			Q9BX26	SYCP2_HUMAN	synaptonemal complex protein 2	266					cell division|meiotic prophase I|synaptonemal complex assembly		DNA binding			NS(4)|breast(2)|central_nervous_system(1)|endometrium(7)|kidney(1)|large_intestine(14)|lung(12)|ovary(4)|prostate(1)|skin(2)|stomach(2)|upper_aerodigestive_tract(2)|urinary_tract(1)	53	all_lung(29;0.00344)		BRCA - Breast invasive adenocarcinoma(7;1.19e-09)			ATTTACAAGGTTGAGAAATAT	0.299000													4	17					0	0	1	0	0
MYO1F	4542	broad.mit.edu	37	19	8609289	8609289	+	Silent	SNP	G	G	A			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr19:8609289G>A	ENST00000338257.8	-	14	1683	c.1416C>T	c.(1414-1416)ggC>ggT	p.G472G		NM_012335.3	NP_036467.2	O00160	MYO1F_HUMAN	myosin IF	472	Myosin head-like.					unconventional myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(3)|kidney(6)|large_intestine(7)|lung(13)|ovary(3)|prostate(3)|skin(3)|urinary_tract(1)	42						CTGCTCCCCCGCCCGTGGCGT	0.667000													13	19					0	0	1	0	0
PKHD1L1	93035	broad.mit.edu	37	8	110467013	110467013	+	Missense_Mutation	SNP	G	G	C			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr8:110467013G>C	ENST00000378402.5	+	45	6910	c.6806G>C	c.(6805-6807)cGa>cCa	p.R2269P		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	2269	G8 1.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GGTCACCTGCGATCTCCTGAG	0.493000										HNSCC(38;0.096)			34	42					0	0	1	0	0
TP53	7157	broad.mit.edu	37	17	7577538	7577538	+	Missense_Mutation	SNP	C	C	T	rs11540652		TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr17:7577538C>T	ENST00000420246.2	-	7	875	c.743G>A	c.(742-744)cGg>cAg	p.R248Q	TP53_ENST00000269305.4_Missense_Mutation_p.R248Q|TP53_ENST00000455263.2_Missense_Mutation_p.R248Q|TP53_ENST00000413465.2_Missense_Mutation_p.R248Q|TP53_ENST00000359597.4_Missense_Mutation_p.R248Q|TP53_ENST00000445888.2_Missense_Mutation_p.R248Q	NM_001126114.2|NM_001276696.1	NP_001119586.1|NP_001263625.1	P04637	P53_HUMAN	tumor protein p53	248	Interaction with AXIN1 (By similarity).|Interaction with HIPK1 (By similarity).|Interacts with the 53BP2 SH3 domain.		NR -> IP (in a sporadic cancer; somatic mutation).|NR -> KW (in sporadic cancers; somatic mutation).|R -> C (in a sporadic cancer; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> L (in sporadic cancers; somatic mutation).|R -> P (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation; dbSNP:rs11540652).|R -> W (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R248Q(580)|p.R248L(75)|p.R248P(19)|p.R155Q(18)|p.0?(8)|p.?(5)|p.R155L(3)|p.R155P(2)|p.N247_R248delNR(2)|p.R248fs*16(2)|p.M246_P250delMNRRP(2)|p.R248_P250delRRP(1)|p.unknown(1)|p.N247_R249delNRR(1)|p.N247_P250delNRRP(1)|p.R249fs*96(1)|p.R248fs*>39(1)|p.R248C(1)|p.G245fs*14(1)|p.N247_R248>IP(1)		NS(16)|adrenal_gland(37)|autonomic_ganglia(16)|biliary_tract(273)|bone(108)|breast(2530)|central_nervous_system(1264)|cervix(68)|endometrium(223)|eye(24)|fallopian_tube(1)|gastrointestinal_tract_(site_indeterminate)(1)|genital_tract(16)|haematopoietic_and_lymphoid_tissue(1301)|kidney(96)|large_intestine(5124)|liver(897)|lung(2388)|meninges(5)|oesophagus(1473)|ovary(1659)|pancreas(452)|penis(10)|peritoneum(33)|pituitary(4)|placenta(1)|pleura(3)|prostate(235)|salivary_gland(43)|skin(791)|small_intestine(14)|soft_tissue(220)|stomach(1158)|testis(11)|thymus(21)|thyroid(54)|upper_aerodigestive_tract(2271)|urinary_tract(1259)|vagina(6)|vulva(79)	24185		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GATGGGCCTCCGGTTCATGCC	0.572000	R248Q(BL41_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CA46_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(CI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(DB_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(EM2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(HCC1143_BREAST)|R248Q(HCC70_BREAST)|R248Q(HEC1A_ENDOMETRIUM)|R248Q(HS683_CENTRAL_NERVOUS_SYSTEM)|R248Q(HSC4_UPPER_AERODIGESTIVE_TRACT)|R248Q(KASUMI1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KOPN8_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KYO1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(KYSE150_OESOPHAGUS)|R248Q(MOLM6_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NAMALWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NB4_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(NCIH211_LUNG)|R248Q(NCIN87_STOMACH)|R248Q(NIHOVCAR3_OVARY)|R248Q(NUDHL1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(P12ICHIKAWA_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(PANC0203_PANCREAS)|R248Q(PC14_LUNG)|R248Q(PF382_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(RT112_URINARY_TRACT)|R248Q(SEM_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SF295_CENTRAL_NERVOUS_SYSTEM)|R248Q(SKUT1_SOFT_TISSUE)|R248Q(SUPT1_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|R248Q(SW1463_LARGE_INTESTINE)|R248Q(WSUDLCL2_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)	111	"""Mis, N, F"""		"""breast, colorectal, lung, sarcoma, adrenocortical, glioma, multiple other tumour types"""	"""breast, sarcoma, adrenocortical carcinoma, glioma, multiple other tumour types"""		Other conserved DNA damage response genes	Osteosarcoma, Familial Clustering of;Li-Fraumeni syndrome;Hereditary Breast-Ovarian Cancer, non-BRCA1/2;Hereditary Adrenocortical Cancer;Endometrial Cancer, Familial Clustering of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			36	5					0	0	1	0	0
RRN3P2	0	broad.mit.edu	37	16	29110458	29110458	+	RNA	SNP	T	T	C	rs151074589	by1000genomes	TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr16:29110458T>C	ENST00000564580.1	+	0	1131																		p.W375R(25)									GAATTTTGAGTGGATAGTGAT	0.328000													3	31					0	0	1	0	0
KLHL34	257240	broad.mit.edu	37	X	21674488	21674488	+	Silent	SNP	G	G	A			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chrX:21674488G>A	ENST00000379499.2	-	1	1960	c.1419C>T	c.(1417-1419)cgC>cgT	p.R473R		NM_153270.1	NP_695002.1	Q8N239	KLH34_HUMAN	kelch-like family member 34	473										cervix(1)|endometrium(7)|kidney(1)|large_intestine(3)|lung(11)|ovary(2)|urinary_tract(1)	26						ACACAACACCGCGGTCCCCGA	0.701000													13	7					0	0	1	0	0
SLC17A9	63910	broad.mit.edu	37	20	61588851	61588851	+	Missense_Mutation	SNP	G	G	A			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr20:61588851G>A	ENST00000370349.3	+	4	502	c.298G>A	c.(298-300)Gtc>Atc	p.V100I	SLC17A9_ENST00000488738.1_3'UTR|SLC17A9_ENST00000370351.4_Missense_Mutation_p.V106I			Q9BYT1	S17A9_HUMAN	solute carrier family 17 (vesicular nucleotide transporter), member 9	106					exocytosis|transmembrane transport	integral to membrane	transporter activity			endometrium(2)|kidney(1)|large_intestine(6)|lung(8)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	23						CATCACGGCCGTCACCCCACT	0.632000													6	81					0	0	1	0	0
PCYT1A	5130	broad.mit.edu	37	3	195974349	195974349	+	Silent	SNP	C	C	T			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr3:195974349C>T	ENST00000292823.2	-	6	547	c.375G>A	c.(373-375)acG>acA	p.T125T	PCYT1A_ENST00000419333.1_Silent_p.T125T|PCYT1A_ENST00000431016.1_Silent_p.T125T|PCYT1A_ENST00000491544.1_5'UTR	NM_005017.2	NP_005008.2	P49585	PCY1A_HUMAN	phosphate cytidylyltransferase 1, choline, alpha	125	Catalytic (Potential).					cytosol|soluble fraction	choline-phosphate cytidylyltransferase activity			cervix(1)|endometrium(3)|large_intestine(8)|lung(5)|ovary(1)	18	all_cancers(143;1.19e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;1.28e-24)|all cancers(36;1.01e-22)|OV - Ovarian serous cystadenocarcinoma(49;3.88e-19)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00259)	Choline(DB00122)	CGTTCATCACCGTGAAGCCTT	0.537000													30	106					0	0	1	0	0
REV3L	5980	broad.mit.edu	37	6	111694285	111694285	+	Missense_Mutation	SNP	A	A	G			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr6:111694285A>G	ENST00000435970.1	-	15	5855	c.5039T>C	c.(5038-5040)aTa>aCa	p.I1680T	REV3L_ENST00000368802.3_Missense_Mutation_p.I1758T|REV3L_ENST00000358835.3_Missense_Mutation_p.I1758T|REV3L_ENST00000368805.1_Missense_Mutation_p.I1758T			O60673	DPOLZ_HUMAN	REV3-like, polymerase (DNA directed), zeta, catalytic subunit	1758					DNA-dependent DNA replication|translesion synthesis	nucleus|zeta DNA polymerase complex	DNA binding|DNA-directed DNA polymerase activity|metal ion binding|nucleotide binding			NS(2)|breast(1)|endometrium(6)|kidney(7)|large_intestine(30)|lung(25)|ovary(3)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	88		all_cancers(87;7.57e-06)|Acute lymphoblastic leukemia(125;2.46e-08)|all_hematologic(75;1.08e-06)|all_epithelial(87;0.00138)|Colorectal(196;0.021)		OV - Ovarian serous cystadenocarcinoma(136;0.0314)|Epithelial(106;0.057)|all cancers(137;0.0663)		AGAATCCATTATTGAGTTAGA	0.393000								DNA polymerases (catalytic subunits)					5	195					0	0	1	0	0
SSTR5	0	broad.mit.edu	37	16	1129080	1129080	+	Missense_Mutation	SNP	T	T	C			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr16:1129080T>C	ENST00000293897.4	+	1	300	c.212T>C	c.(211-213)aTg>aCg	p.M71T	SSTR5_ENST00000562758.1_Missense_Mutation_p.M71T|SSTR5_ENST00000397547.2_Missense_Mutation_p.M71T	NM_001053.3	NP_001044.1	P35346	SSR5_HUMAN	somatostatin receptor 5	71					negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			endometrium(2)|lung(5)|prostate(1)|skin(1)	9		Hepatocellular(780;0.00369)			Octreotide(DB00104)	TTCGCCAAGATGAAGACCGTC	0.647000													15	22					0	0	1	0	0
FLYWCH1	84256	broad.mit.edu	37	16	2983818	2983818	+	Missense_Mutation	SNP	A	A	C			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr16:2983818A>C	ENST00000399667.2	+	6	1714	c.1351A>C	c.(1351-1353)Acc>Ccc	p.T451P	FLYWCH1_ENST00000253928.9_Missense_Mutation_p.T451P|FLYWCH1_ENST00000416288.2_Missense_Mutation_p.T450P			Q4VC44	FWCH1_HUMAN	FLYWCH-type zinc finger 1	451						nucleus	DNA binding|metal ion binding			kidney(1)|lung(3)	4						GGTGTATTGGACCTGCCGGGA	0.692000													4	12					0	0	1	0	0
MED12	9968	broad.mit.edu	37	X	70360623	70360623	+	Silent	SNP	A	A	G			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chrX:70360623A>G	ENST00000333646.6	+	42	6391	c.6192A>G	c.(6190-6192)caA>caG	p.Q2064Q	MED12_ENST00000374080.3_Silent_p.Q2061Q|MED12_ENST00000374102.1_Silent_p.Q2060Q|MED12_ENST00000478889.1_3'UTR	NM_005120.2	NP_005111.2	Q93074	MED12_HUMAN	mediator complex subunit 12	2061	Gln-rich.				androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			breast(6)|central_nervous_system(2)|endometrium(22)|kidney(5)|large_intestine(8)|lung(31)|ovary(2)|pancreas(1)|prostate(11)|skin(5)|soft_tissue(323)|upper_aerodigestive_tract(1)|urinary_tract(3)	420	Renal(35;0.156)					agcaacagcaacagcagcagc	0.602000			"""M, S"""		uterine leiomyoma		Opitz-Kaveggia Syndrome						4	110					0	0	1	0	0
ABCA7	10347	broad.mit.edu	37	19	1044627	1044627	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr19:1044627C>T	ENST00000263094.6	+	11	1330	c.1099C>T	c.(1099-1101)Cgg>Tgg	p.R367W	ABCA7_ENST00000435683.2_Missense_Mutation_p.R229W|ABCA7_ENST00000433129.1_Missense_Mutation_p.R367W	NM_019112.3	NP_061985.2	Q8IZY2	ABCA7_HUMAN	ATP-binding cassette, sub-family A (ABC1), member 7	367					phagocytosis|transmembrane transport	ATP-binding cassette (ABC) transporter complex|endosome membrane|Golgi membrane|integral to membrane|plasma membrane	ATP binding|ATPase activity|transporter activity			NS(1)|central_nervous_system(1)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(8)|large_intestine(7)|lung(22)|ovary(1)|pancreas(7)|prostate(4)|skin(3)|upper_aerodigestive_tract(1)	65		Acute lymphoblastic leukemia(61;2.53e-14)|all_hematologic(61;8.18e-10)|Lung NSC(49;1.04e-05)|all_lung(49;1.53e-05)|Breast(49;9.42e-05)|Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		ACCTGGAGGCCGGGACCACAT	0.657000													21	21					0	0	1	0	0
TIMELESS	8914	broad.mit.edu	37	12	56817131	56817131	+	Missense_Mutation	SNP	G	G	C			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr12:56817131G>C	ENST00000229201.4	-	18	2370	c.2216C>G	c.(2215-2217)gCc>gGc	p.A739G	TIMELESS_ENST00000554616.1_Intron|TIMELESS_ENST00000553532.1_Missense_Mutation_p.A740G	NM_003920.3	NP_003911.2	Q9UNS1	TIM_HUMAN	timeless circadian clock	740					cell division|circadian rhythm|detection of abiotic stimulus|mitosis|morphogenesis of an epithelium|negative regulation of transcription, DNA-dependent|regulation of S phase|response to DNA damage stimulus|transcription, DNA-dependent	nuclear chromatin				NS(1)|breast(2)|cervix(3)|endometrium(3)|kidney(3)|large_intestine(8)|lung(14)|ovary(7)|pancreas(2)|prostate(3)|skin(1)|stomach(1)|urinary_tract(1)	49						AAAAAGTAGGGCTTCCATTTT	0.502000													28	82					0	0	1	0	0
NPY	4852	broad.mit.edu	37	7	24324969	24324969	+	Missense_Mutation	SNP	G	G	A			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr7:24324969G>A	ENST00000407573.1	+	3	400	c.110G>A	c.(109-111)gGc>gAc	p.G37D	NPY_ENST00000405982.1_Missense_Mutation_p.G37D|NPY_ENST00000242152.2_Missense_Mutation_p.G37D			P01303	NPY_HUMAN	neuropeptide Y	37					adult feeding behavior|calcium ion transport|cell proliferation|cellular component movement|central nervous system neuron development|cerebral cortex development|digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|neuron projection development|neuropeptide signaling pathway|positive regulation of appetite|synaptic transmission	cell|extracellular space	calcium channel regulator activity|G-protein coupled receptor activity|neuropeptide hormone activity			breast(1)|kidney(1)|large_intestine(4)|lung(2)|upper_aerodigestive_tract(1)	9						GACAACCCGGGCGAGGACGCA	0.672000													16	28					0	0	1	0	0
CTC-260E6.6	0	broad.mit.edu	37	19	20369191	20369191	+	RNA	SNP	T	T	C			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr19:20369191T>C	ENST00000593655.1	-	0	199																											GTGGGAAACATTGAAATCAAG	0.408000													25	40					0	0	1	0	0
ZFP90	146198	broad.mit.edu	37	16	68597568	68597568	+	Missense_Mutation	SNP	A	A	G			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr16:68597568A>G	ENST00000570495.1	+	5	1170	c.878A>G	c.(877-879)cAt>cGt	p.H293R	ZFP90_ENST00000563169.2_Missense_Mutation_p.H293R|RP11-615I2.7_ENST00000571720.1_RNA|ZFP90_ENST00000398253.2_Missense_Mutation_p.H293R			Q8TF47	ZFP90_HUMAN	ZFP90 zinc finger protein	293					positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|kidney(2)|large_intestine(7)|lung(10)|ovary(1)|prostate(1)|skin(2)|upper_aerodigestive_tract(2)	27		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00233)|Epithelial(162;0.0184)|all cancers(182;0.0946)		GCCTTCAGGCATAGCTCATCT	0.488000													54	30					0	0	1	0	0
CCDC158	339965	broad.mit.edu	37	4	77290771	77290771	+	Silent	SNP	A	A	G			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr4:77290771A>G	ENST00000388914.3	-	10	1307	c.1155T>C	c.(1153-1155)gaT>gaC	p.D385D		NM_001042784.1	NP_001036249.1	Q5M9N0	CD158_HUMAN	coiled-coil domain containing 158	385										breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(9)|lung(28)|ovary(3)|pancreas(1)|prostate(1)|skin(6)|stomach(1)	56						TTTTGTGTAGATCAGCCTAAA	0.408000													4	60					0	0	1	0	0
TRPM4	54795	broad.mit.edu	37	19	49671542	49671542	+	Silent	SNP	G	G	T			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr19:49671542G>T	ENST00000252826.5	+	5	600	c.474G>T	c.(472-474)ctG>ctT	p.L158L	TRPM4_ENST00000355712.5_Intron|TRPM4_ENST00000427978.2_Silent_p.L158L	NM_017636.3	NP_060106.2	Q8TD43	TRPM4_HUMAN	transient receptor potential cation channel, subfamily M, member 4	158					dendritic cell chemotaxis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cell proliferation|protein sumoylation|regulation of T cell cytokine production	endoplasmic reticulum|Golgi apparatus|integral to membrane|plasma membrane	ATP binding|calcium activated cation channel activity|calmodulin binding			breast(2)|central_nervous_system(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(2)|large_intestine(2)|lung(18)|ovary(2)|prostate(4)|skin(4)|upper_aerodigestive_tract(3)|urinary_tract(2)	49		all_lung(116;8.54e-05)|Lung NSC(112;0.000139)|all_neural(266;0.0506)|Ovarian(192;0.15)		all cancers(93;2.88e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000222)|GBM - Glioblastoma multiforme(486;0.00339)|Epithelial(262;0.00751)		CTGGGGGTCTGCACACGGGCA	0.607000													11	233					0.0167234	0.0173605	1	1	0
WHSC1L1	54904	broad.mit.edu	37	8	38178629	38178629	+	Silent	SNP	G	G	T			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr8:38178629G>T	ENST00000317025.8	-	8	2287	c.1770C>A	c.(1768-1770)tcC>tcA	p.S590S	WHSC1L1_ENST00000527502.1_Silent_p.S590S|WHSC1L1_ENST00000316985.3_Silent_p.S590S|WHSC1L1_ENST00000433384.2_Silent_p.S590S	NM_023034.1	NP_075447.1	Q9BZ95	NSD3_HUMAN	Wolf-Hirschhorn syndrome candidate 1-like 1	590					cell differentiation|cell growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome	histone-lysine N-methyltransferase activity|zinc ion binding			NS(1)|breast(2)|endometrium(3)|kidney(3)|large_intestine(2)|lung(10)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	24	Colorectal(12;0.000442)|Esophageal squamous(3;0.0725)	all_lung(54;0.00787)|Lung NSC(58;0.0295)|Hepatocellular(245;0.065)	Epithelial(3;3.12e-43)|all cancers(3;1.72e-38)|BRCA - Breast invasive adenocarcinoma(5;2.84e-27)|LUSC - Lung squamous cell carcinoma(2;2.79e-25)|Lung(2;5.03e-23)|COAD - Colon adenocarcinoma(9;0.0511)			CAACCTCAGTGGATTTCTCTG	0.358000			T	NUP98	AML								22	37					1.10513e-12	1.24185e-12	1	1	0
CROCCP2	0	broad.mit.edu	37	1	16946336	16946336	+	RNA	SNP	G	G	A	rs11586784	by1000genomes	TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr1:16946336G>A	ENST00000412962.1	-	0	1183																											CAGGGCTCACGAACCTGCTGC	0.662000													4	30					0	0	1	0	0
PRDM8	56978	broad.mit.edu	37	4	81123237	81123237	+	Silent	SNP	C	C	T			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr4:81123237C>T	ENST00000339711.4	+	10	1852	c.621C>T	c.(619-621)ggC>ggT	p.G207G	PRDM8_ENST00000504452.1_Silent_p.G207G|PRDM8_ENST00000415738.2_Silent_p.G207G	NM_020226.3	NP_064611.3	Q9NQV8	PRDM8_HUMAN	PR domain containing 8	207	Gly-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(2)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(2)|skin(2)	10						gcggcggcggcggtggcaaag	0.657000											OREG0016246	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	88					0	0	1	0	0
PASK	23178	broad.mit.edu	37	2	242062240	242062240	+	Silent	SNP	G	G	A			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr2:242062240G>A	ENST00000403638.3	-	12	3070	c.2979C>T	c.(2977-2979)ggC>ggT	p.G993G	PASK_ENST00000539818.1_Silent_p.G777G|PASK_ENST00000405260.1_Silent_p.G993G|PASK_ENST00000544142.1_Silent_p.G807G|PASK_ENST00000234040.4_Silent_p.G993G|PASK_ENST00000358649.4_Silent_p.G993G	NM_001252124.1	NP_001239053.1	Q96RG2	PASK_HUMAN	PAS domain containing serine/threonine kinase	993					regulation of transcription, DNA-dependent	Golgi apparatus	ATP binding|identical protein binding|protein serine/threonine kinase activity|signal transducer activity			NS(1)|breast(1)|central_nervous_system(1)|endometrium(7)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(6)|lung(20)|ovary(4)|prostate(4)|skin(1)|stomach(1)|urinary_tract(2)	53		all_cancers(19;4.46e-39)|all_epithelial(40;1.34e-17)|Breast(86;1.53e-05)|Renal(207;0.00179)|all_lung(227;0.00481)|Lung NSC(271;0.017)|Ovarian(221;0.0228)|Esophageal squamous(248;0.129)|all_hematologic(139;0.158)|Melanoma(123;0.16)|all_neural(83;0.243)|Hepatocellular(293;0.244)		Epithelial(32;1.34e-31)|all cancers(36;1e-28)|OV - Ovarian serous cystadenocarcinoma(60;3.53e-14)|Kidney(56;4.31e-09)|KIRC - Kidney renal clear cell carcinoma(57;4.35e-08)|BRCA - Breast invasive adenocarcinoma(100;5.64e-06)|Lung(119;0.000596)|LUSC - Lung squamous cell carcinoma(224;0.00481)|Colorectal(34;0.014)|COAD - Colon adenocarcinoma(134;0.0968)		GGGAGTACTCGCCCTCACAGG	0.587000													26	71					0	0	1	0	0
ZNF676	163223	broad.mit.edu	37	19	22375867	22375867	+	Silent	SNP	T	T	C			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr19:22375867T>C	ENST00000397121.2	-	2	398	c.81A>G	c.(79-81)ggA>ggG	p.G27G		NM_001001411.2	NP_001001411.2	Q8N7Q3	ZN676_HUMAN	zinc finger protein 676	27	KRAB.		G -> E (in dbSNP:rs8104929).		regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(9)|lung(49)|pancreas(1)|prostate(2)|upper_aerodigestive_tract(2)	67		Lung NSC(12;0.0207)|all_lung(12;0.0214)|all_epithelial(12;0.114)				AGGGCTCTTTTCCTTGCTCCA	0.403000													4	104					0	0	1	0	0
KIRREL3	84623	broad.mit.edu	37	11	126305176	126305176	+	Silent	SNP	G	G	A			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr11:126305176G>A	ENST00000525144.2	-	13	1824	c.1575C>T	c.(1573-1575)gcC>gcT	p.A525A	KIRREL3_ENST00000416561.2_Intron|KIRREL3_ENST00000529097.2_Intron|KIRREL3_ENST00000525704.2_Silent_p.A525A	NM_032531.3	NP_115920.1	Q8IZU9	KIRR3_HUMAN	kin of IRRE like 3 (Drosophila)	525					hemopoiesis	extracellular region|integral to membrane|plasma membrane	protein binding			central_nervous_system(1)|endometrium(5)|large_intestine(11)|lung(8)|ovary(3)|prostate(1)	29	all_hematologic(175;0.145)	Lung NSC(97;0.0484)|all_lung(97;0.0522)|Medulloblastoma(222;0.0523)|Breast(109;0.0949)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;6.03e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.12)		CTTCCAGCCCGGCTCCCGACT	0.607000													32	5					0	0	1	0	0
TPRN	286262	broad.mit.edu	37	9	140086700	140086700	+	Missense_Mutation	SNP	C	C	T			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr9:140086700C>T	ENST00000321773.2	-	3	1900	c.1901G>A	c.(1900-1902)gGg>gAg	p.G634E	TPRN_ENST00000409012.4_Intron			Q4KMQ1	TPRN_HUMAN	taperin	691					sensory perception of sound	stereocilium				breast(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(2)|prostate(2)	8						CTCCACTCCCCCGCATCTCAC	0.662000													53	57					0	0	1	0	0
C7orf50	84310	broad.mit.edu	37	7	1167007	1167007	+	Missense_Mutation	SNP	C	C	A			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr7:1167007C>A	ENST00000397098.3	-	2	941	c.15G>T	c.(13-15)aaG>aaT	p.K5N	C7orf50_ENST00000397100.2_Missense_Mutation_p.K5N|C7orf50_ENST00000357429.6_Missense_Mutation_p.K5N|C7orf50_ENST00000488073.1_5'UTR			Q9BRJ6	CG050_HUMAN	chromosome 7 open reading frame 50	5							protein binding			kidney(1)|large_intestine(1)|lung(3)|ovary(1)	6		Ovarian(82;0.0779)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0216)|OV - Ovarian serous cystadenocarcinoma(56;1.3e-15)		GAACTTTTCTCTTCTGTTTTG	0.443000													4	3					0.150653	0.152048	1	1	0
ROBO2	6092	broad.mit.edu	37	3	77595594	77595594	+	Nonsense_Mutation	SNP	G	G	A			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr3:77595594G>A	ENST00000461745.1	+	7	1940	c.1040G>A	c.(1039-1041)tGg>tAg	p.W347*	ROBO2_ENST00000332191.8_Nonsense_Mutation_p.W347*|ROBO2_ENST00000487694.3_Nonsense_Mutation_p.W363*	NM_002942.4	NP_002933.1	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2 (Drosophila)	347	Ig-like C2-type 4.				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			NS(1)|biliary_tract(5)|breast(3)|central_nervous_system(1)|cervix(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(23)|liver(1)|lung(52)|ovary(2)|pancreas(2)|prostate(5)|skin(8)|upper_aerodigestive_tract(1)	117				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		GCTGTTTTTTGGCAGAAAGAA	0.478000													27	179					0	0	1	0	0
PIK3CA	5290	broad.mit.edu	37	3	178916957	178916957	+	Missense_Mutation	SNP	G	G	T			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr3:178916957G>T	ENST00000263967.3	+	2	501	c.344G>T	c.(343-345)cGa>cTa	p.R115L		NM_006218.2	NP_006209.2	P42336	PK3CA_HUMAN	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha	115					epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|platelet activation|T cell costimulation|T cell receptor signaling pathway		1-phosphatidylinositol-3-kinase activity|ATP binding|phosphatidylinositol-4,5-bisphosphate 3-kinase activity	p.R115L(3)		NS(16)|autonomic_ganglia(4)|biliary_tract(22)|bone(1)|breast(2150)|central_nervous_system(110)|cervix(33)|endometrium(473)|eye(1)|haematopoietic_and_lymphoid_tissue(35)|kidney(14)|large_intestine(1202)|liver(42)|lung(202)|meninges(1)|oesophagus(28)|ovary(235)|pancreas(17)|penis(8)|pituitary(12)|prostate(10)|skin(155)|small_intestine(1)|soft_tissue(18)|stomach(121)|thyroid(80)|upper_aerodigestive_tract(70)|urinary_tract(208)	5269	all_cancers(143;1.19e-17)|Ovarian(172;0.00769)|Breast(254;0.155)		OV - Ovarian serous cystadenocarcinoma(80;9.59e-28)|GBM - Glioblastoma multiforme(14;0.003)|BRCA - Breast invasive adenocarcinoma(182;0.0282)			ATCCTCAATCGAGAAATTGGT	0.333000		57	Mis		"""colorectal, gastric, gliobastoma, breast"""					HNSCC(19;0.045)|TSP Lung(28;0.18)			26	36					1.1804e-14	1.36876e-14	1	1	0
NPIPB5	100132247	broad.mit.edu	37	16	22546256	22546256	+	Missense_Mutation	SNP	A	A	T			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr16:22546256A>T	ENST00000424340.1	+	7	2231	c.1952A>T	c.(1951-1953)cAc>cTc	p.H651L	NPIPB5_ENST00000517539.1_Missense_Mutation_p.H651L|NPIPB5_ENST00000415654.1_3'UTR	NM_001135865.1	NP_001129337.1			nuclear pore complex interacting protein family, member B5																		ATATCAAGACACCTGCCGAGC	0.577000													6	162					0	0	1	0	0
PRODH2	58510	broad.mit.edu	37	19	36297437	36297437	+	Missense_Mutation	SNP	C	C	A			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr19:36297437C>A	ENST00000301175.3	-	8	1141	c.1124G>T	c.(1123-1125)gGa>gTa	p.G375V		NM_021232.1	NP_067055.1	Q9UF12	PROD2_HUMAN	proline dehydrogenase (oxidase) 2	375					glutamate biosynthetic process|proline catabolic process		proline dehydrogenase activity			haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(9)|ovary(2)|prostate(2)|skin(2)|upper_aerodigestive_tract(1)	21	all_lung(56;2.87e-07)|Lung NSC(56;4.32e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CAGCTTCACTCCGAAGGCCAG	0.622000													81	223					7.81431e-29	9.25826e-29	1	1	0
RP11-262H14.1	0	broad.mit.edu	37	9	66457330	66457330	+	RNA	SNP	G	G	T			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr9:66457330G>T	ENST00000424345.1	+	0	42																											cagcgacagagccttggagag	0.632000													4	13					1	1	1	1	0
PDE4DIP	9659	broad.mit.edu	37	1	145014238	145014238	+	Frame_Shift_Del	DEL	C	C	-			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr1:145014238delC	ENST00000493130.2	-	4	465	c.304delG	c.(304-306)aafs	p.E102fs	PDE4DIP_ENST00000369359.4_Intron|PDE4DIP_ENST00000313382.9_Intron|PDE4DIP_ENST00000530740.1_Intron|PDE4DIP_ENST00000369348.3_Intron			Q5VU43	MYOME_HUMAN	phosphodiesterase 4D interacting protein	0					cellular protein complex assembly	centrosome|Golgi apparatus|myofibril|nucleus	enzyme binding			NS(1)|breast(3)|central_nervous_system(2)|cervix(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(2)|kidney(9)|large_intestine(12)|lung(106)|ovary(8)|prostate(7)|skin(3)|upper_aerodigestive_tract(4)|urinary_tract(2)	176				Colorectal(2;0.0829)|COAD - Colon adenocarcinoma(2;0.126)		ATCCTTGCTTCCCCCACCAGC	0.443			T	PDGFRB	MPD								2	4	---	---	---	---					
RP11-481J13.1	0	broad.mit.edu	37	2	56259444	56259444	+	RNA	DEL	T	T	-			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr2:56259444delT	ENST00000606639.1	+	0	82				AC011306.2_ENST00000446139.1_lincRNA																							ggctgccatattatttgcatt	0.458													2	4	---	---	---	---					
AC093639.1	0	broad.mit.edu	37	2	184781026	184781026	+	RNA	DEL	C	C	-	rs113400092		TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr2:184781026delC	ENST00000441026.1	+	0	103																											aggaggcctgcctgcctctgt	0.527													3	4	---	---	---	---					
LINC00969	0	broad.mit.edu	37	3	195403822	195403822	+	RNA	DEL	A	A	-			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr3:195403822delA	ENST00000445430.1	+	0	1454																											attccatctcaaaaaaaaaaa	0.483													2	4	---	---	---	---					
RP11-153M7.3	0	broad.mit.edu	37	4	154587193	154587193	+	RNA	DEL	C	C	-			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr4:154587193delC	ENST00000602666.1	+	0	355																											ttggcagcttccacatggtgt	0.517													2	4	---	---	---	---					
CTD-2281E23.3	0	broad.mit.edu	37	8	1197216	1197217	+	RNA	INS	-	-	G	rs66848317	by1000genomes	TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr8:1197216_1197217insG	ENST00000517950.1	-	0	278																											GAGATCAGTGTGGAGTGATGGT	0.584													2	4	---	---	---	---					
RP11-531A24.5	0	broad.mit.edu	37	8	73965434	73965435	+	RNA	INS	-	-	GTTTTGTTTTGTTTT	rs141422515	by1000genomes	TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr8:73965434_73965435insGTTTTGTTTTGTTTT	ENST00000517664.1	+	0	1022_1023																											tgttttttttggttttgttttg	0.436													2	4	---	---	---	---					
CEL	1056	broad.mit.edu	37	9	135946987	135946988	+	Frame_Shift_Ins	INS	-	-	C			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr9:135946987_135946988insC	ENST00000372080.4	+	11	2123_2124	c.2107_2108insC	c.(2107-2109)cccfs	p.P703fs	CEL_ENST00000351304.7_Frame_Shift_Ins_p.P634fs	NM_001807.3	NP_001798.2	P19835	CEL_HUMAN	carboxyl ester lipase	700	17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type).				cholesterol catabolic process|fatty acid catabolic process|intestinal cholesterol absorption|intestinal lipid catabolic process|pancreatic juice secretion|protein esterification	cytosol|extracellular space	acylglycerol lipase activity|carboxylesterase activity|heparin binding|sterol esterase activity|triglyceride lipase activity			NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(9)|pancreas(2)|skin(1)	20				OV - Ovarian serous cystadenocarcinoma(145;1.03e-40)|Epithelial(140;3.58e-37)|GBM - Glioblastoma multiforme(294;0.00164)|READ - Rectum adenocarcinoma(205;0.196)		TGACTCCGGGGCCCCCCCCGTG	0.822													3	4	---	---	---	---					
RP11-282I1.1	0	broad.mit.edu	37	10	125119044	125119044	+	RNA	DEL	A	A	-			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr10:125119044delA	ENST00000448347.1	+	0	95																											cgtctctaccaaaaatacaaa	0.522													2	4	---	---	---	---					
RP11-387D10.2	0	broad.mit.edu	37	15	91190540	91190541	+	RNA	INS	-	-	TTA			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr15:91190540_91190541insTTA	ENST00000559531.1	-	0	294																											ccacaatcctcctccacacccc	0.629													2	4	---	---	---	---					
RP11-19N8.2	0	broad.mit.edu	37	16	33037352	33037352	+	RNA	DEL	T	T	-			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr16:33037352delT	ENST00000567619.1	-	0	499																											TAAATGACAATGAATTTTTTT	0.388													2	4	---	---	---	---					
AC061992.2	0	broad.mit.edu	37	17	76332835	76332835	+	RNA	DEL	T	T	-			TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr17:76332835delT	ENST00000586321.1	+	0	60																											AAATAATAACttttttttttt	0.453													2	4	---	---	---	---					
RP11-78F17.1	0	broad.mit.edu	37	18	983013	983014	+	RNA	INS	-	-	C	rs72094579	by1000genomes	TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr18:983013_983014insC	ENST00000580781.1	+	0	306																											aaccatggccgccccccaccca	0.525													5	4	---	---	---	---					
SEC1P	0	broad.mit.edu	37	19	49177697	49177697	+	RNA	DEL	G	G	-	rs147031859		TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr19:49177697delG	ENST00000430145.2	+	0	368					NR_004401.2																						GTGATGCGGAGGGGCATTTGT	0.612													3	3	---	---	---	---					
RP4-610C12.1	0	broad.mit.edu	37	20	29589297	29589297	+	RNA	DEL	C	C	-	rs73620372	by1000genomes	TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr20:29589297delC	ENST00000432067.1	-	0	152																											cttagcacttcttttgctgca	0.299													4	6	---	---	---	---					
BAGE2	85319	broad.mit.edu	37	21	11066244	11066249	+	RNA	DEL	CAAAAA	CAAAAA	-	rs4039879		TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chr21:11066244_11066249delCAAAAA	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		gactccatctcaaaaacaaaaacaaa	0.403													4	3	---	---	---	---					
RP11-761E20.1	0	broad.mit.edu	37	X	115052547	115052547	+	RNA	DEL	C	C	-	rs60378274		TCGA-N9-A4PZ-01A-22D-A28R-08	TCGA-N9-A4PZ-11A-11D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	890d1036-212b-411e-8b07-36d70d5dd880	54e22e93-595e-4bde-8e35-edcb044c0479	g.chrX:115052547delC	ENST00000430756.1	-	0	200																											gctctcccttcccccagaaca	0.502													3	4	---	---	---	---					
