Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_alt_allele	validation_method	validation_status	validation_tumor_sample	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
FAM47B	170062	broad.mit.edu	37	X	34962328	34962328	+	Silent	SNP	G	G	A			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chrX:34962328G>A	ENST00000329357.5	+	1	1416	c.1380G>A	c.(1378-1380)tcG>tcA	p.S460S		NM_152631.2	NP_689844.2	Q8NA70	FA47B_HUMAN	family with sequence similarity 47, member B	460										breast(3)|central_nervous_system(3)|endometrium(8)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(13)|lung(28)|ovary(4)|prostate(3)|skin(2)|upper_aerodigestive_tract(3)	71						GACACACATCGAGAAAACTCC	0.468000													44	55					0	0	1	0	0
ZC3H6	376940	broad.mit.edu	37	2	113089467	113089467	+	Missense_Mutation	SNP	C	C	T			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr2:113089467C>T	ENST00000409871.1	+	12	3373	c.2972C>T	c.(2971-2973)gCa>gTa	p.A991V	ZC3H6_ENST00000343936.4_Missense_Mutation_p.A991V	NM_198581.2	NP_940983.2	P61129	ZC3H6_HUMAN	zinc finger CCCH-type containing 6	991							nucleic acid binding|zinc ion binding			central_nervous_system(2)|endometrium(3)|kidney(3)|large_intestine(9)|lung(12)|ovary(4)|prostate(2)	35						GATTCACATGCATCAAAGGGT	0.473000													15	18					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628282	29628282	+	Missense_Mutation	SNP	G	G	A			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr20:29628282G>A	ENST00000278882.3	+	6	664	c.284G>A	c.(283-285)gGg>gAg	p.G95E	FRG1B_ENST00000358464.4_Missense_Mutation_p.G95E|FRG1B_ENST00000439954.2_Missense_Mutation_p.G100E																endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						AATGAAGCAGGGGACATAGAA	0.373000													6	104					0	0	1	0	0
FAM171B	165215	broad.mit.edu	37	2	187615972	187615972	+	Missense_Mutation	SNP	G	G	A			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr2:187615972G>A	ENST00000304698.5	+	5	1039	c.836G>A	c.(835-837)cGt>cAt	p.R279H		NM_177454.3	NP_803237.3	Q6P995	F171B_HUMAN	family with sequence similarity 171, member B	279						integral to membrane	DNA binding			NS(1)|breast(6)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(10)|lung(22)|ovary(6)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	54						CCTCTTCTACGTCTGAATGAT	0.363000													9	27					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11058340	11058340	+	RNA	SNP	A	A	C	rs28617310	by1000genomes	TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr21:11058340A>C	ENST00000470054.1	-	0	324									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		GGGGTAAAGGAGAGAAATCTC	0.363000													4	80					0	0	1	0	0
ARHGEF10L	55160	broad.mit.edu	37	1	17966763	17966763	+	Missense_Mutation	SNP	G	G	T			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr1:17966763G>T	ENST00000361221.3	+	21	2397	c.2238G>T	c.(2236-2238)tgG>tgT	p.W746C	ARHGEF10L_ENST00000375415.1_Missense_Mutation_p.W707C|ARHGEF10L_ENST00000452522.1_Missense_Mutation_p.W707C|ARHGEF10L_ENST00000167825.4_Missense_Mutation_p.W449C|ARHGEF10L_ENST00000434513.1_Missense_Mutation_p.W741C|ARHGEF10L_ENST00000469726.1_3'UTR|ARHGEF10L_ENST00000375408.3_Missense_Mutation_p.W519C	NM_018125.3	NP_060595.3	Q9HCE6	ARGAL_HUMAN	Rho guanine nucleotide exchange factor (GEF) 10-like	746					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(4)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|liver(2)|lung(16)|ovary(4)|pancreas(1)|prostate(3)|skin(1)|upper_aerodigestive_tract(1)	43		Colorectal(325;3.46e-05)|Breast(348;0.000162)|all_lung(284;0.000337)|Lung NSC(340;0.000419)|Renal(390;0.000518)|Ovarian(437;0.00409)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00598)|COAD - Colon adenocarcinoma(227;1.62e-05)|BRCA - Breast invasive adenocarcinoma(304;1.68e-05)|Kidney(64;0.000269)|KIRC - Kidney renal clear cell carcinoma(64;0.00361)|STAD - Stomach adenocarcinoma(196;0.00656)|READ - Rectum adenocarcinoma(331;0.0718)|Lung(427;0.204)		AGATTTCCTGGGTCAACAGGT	0.572000													12	0					2.27111e-07	2.52038e-07	1	1	0
PCDH11X	27328	broad.mit.edu	37	X	91090729	91090729	+	Nonsense_Mutation	SNP	C	C	T			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chrX:91090729C>T	ENST00000373094.1	+	1	1071	c.226C>T	c.(226-228)Cga>Tga	p.R76*	PCDH11X_ENST00000373097.1_Nonsense_Mutation_p.R76*|PCDH11X_ENST00000361655.2_Nonsense_Mutation_p.R76*|PCDH11X_ENST00000395337.2_Nonsense_Mutation_p.R76*|PCDH11X_ENST00000504220.1_Nonsense_Mutation_p.R76*|PCDH11X_ENST00000361724.1_Nonsense_Mutation_p.R76*|PCDH11X_ENST00000373088.1_Nonsense_Mutation_p.R76*|PCDH11X_ENST00000298274.8_Nonsense_Mutation_p.R76*|PCDH11X_ENST00000406881.1_Nonsense_Mutation_p.R76*	NM_032968.3	NP_116750.1	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked	76	Cadherin 1.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			NS(1)|autonomic_ganglia(1)|biliary_tract(1)|central_nervous_system(1)|cervix(1)|endometrium(12)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(30)|liver(4)|lung(92)|prostate(2)|skin(1)|stomach(1)|upper_aerodigestive_tract(5)|urinary_tract(1)	159						GCCACTGATTCGAATTGAAGA	0.443000													52	102					0	0	1	0	0
USP11	8237	broad.mit.edu	37	X	47101057	47101057	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chrX:47101057G>T	ENST00000377107.2	+	9	1492	c.1138G>T	c.(1138-1140)Gag>Tag	p.E380*	USP11_ENST00000218348.3_Nonsense_Mutation_p.E423*			P51784	UBP11_HUMAN	ubiquitin specific peptidase 11	423					protein deubiquitination|ubiquitin-dependent protein catabolic process	cytoplasm|nucleus	cysteine-type endopeptidase activity|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			breast(2)|central_nervous_system(2)|cervix(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(9)|lung(14)|ovary(3)|pancreas(1)|stomach(1)	40						GAAGAAGAAGGAGTATGTGGA	0.567000													23	23					1.9806e-07	2.22512e-07	1	1	0
C3	718	broad.mit.edu	37	19	6678426	6678426	+	Silent	SNP	G	G	A			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr19:6678426G>A	ENST00000245907.6	-	39	4763	c.4671C>T	c.(4669-4671)gaC>gaT	p.D1557D	C3_ENST00000599668.1_5'UTR	NM_000064.2	NP_000055.2	P01024	CO3_HUMAN	complement component 3	1557	NTR.				complement activation, alternative pathway|complement activation, classical pathway|G-protein coupled receptor protein signaling pathway|inflammatory response|positive regulation vascular endothelial growth factor production	extracellular space	endopeptidase inhibitor activity|receptor binding			breast(5)|endometrium(7)|kidney(6)|large_intestine(18)|liver(1)|lung(18)|ovary(1)|pancreas(1)|prostate(5)|skin(7)|upper_aerodigestive_tract(3)	72				GBM - Glioblastoma multiforme(1328;1.36e-05)|Lung(535;0.00661)		ACTCGTCAAAGTCATTGGACA	0.582000													14	12					0	0	1	0	0
SEMA3D	223117	broad.mit.edu	37	7	84628909	84628909	+	Silent	SNP	G	G	A			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr7:84628909G>A	ENST00000284136.6	-	17	2224	c.2181C>T	c.(2179-2181)ctC>ctT	p.L727L	SEMA3D_ENST00000484038.1_5'UTR	NM_152754.2	NP_689967.2	O95025	SEM3D_HUMAN	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D	727					cell differentiation|nervous system development	extracellular region|membrane	receptor activity			NS(1)|breast(2)|cervix(1)|endometrium(9)|kidney(2)|large_intestine(19)|lung(29)|ovary(3)|pancreas(1)|prostate(4)|skin(2)	73						AGTACTGGTCGAGGCTGAAGT	0.512000													20	42					0	0	1	0	0
KAT2B	8850	broad.mit.edu	37	3	20082165	20082165	+	Nonsense_Mutation	SNP	G	G	T			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr3:20082165G>T	ENST00000263754.4	+	1	651	c.196G>T	c.(196-198)Gga>Tga	p.G66*		NM_003884.4	NP_003875.3	Q92831	KAT2B_HUMAN	K(lysine) acetyltransferase 2B	66					cell cycle arrest|cellular response to insulin stimulus|chromatin remodeling|histone H3 acetylation|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|negative regulation of cell proliferation|transcription initiation from RNA polymerase I promoter	Ada2/Gcn5/Ada3 transcription activator complex|chromatin remodeling complex|PCAF complex	cyclin-dependent protein kinase inhibitor activity|histone acetyltransferase activity|histone deacetylase binding|protein kinase binding|transcription coactivator activity|transcription factor binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(10)|lung(15)|ovary(1)|pancreas(1)|prostate(1)|skin(2)|urinary_tract(1)	40						CACGGCCGAAGGACCGGGAGG	0.746000													5	17					5.9392e-07	6.51165e-07	1	1	0
PLCL1	5334	broad.mit.edu	37	2	198950127	198950127	+	Missense_Mutation	SNP	A	A	T			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr2:198950127A>T	ENST00000428675.1	+	2	2284	c.1886A>T	c.(1885-1887)gAg>gTg	p.E629V	PLCL1_ENST00000437704.2_Missense_Mutation_p.E531V	NM_006226.3	NP_006217.3	Q15111	PLCL1_HUMAN	phospholipase C-like 1	629	PI-PLC Y-box.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			autonomic_ganglia(1)|breast(1)|cervix(1)|endometrium(8)|kidney(1)|large_intestine(14)|lung(44)|ovary(1)|pancreas(2)|prostate(1)|skin(4)|upper_aerodigestive_tract(1)|urinary_tract(1)	80					Quinacrine(DB01103)	GAGTACCCAGAGGATTTTGTT	0.368000													7	24					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628243	29628243	+	Missense_Mutation	SNP	T	T	C			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr20:29628243T>C	ENST00000278882.3	+	6	625	c.245T>C	c.(244-246)tTg>tCg	p.L82S	FRG1B_ENST00000358464.4_Missense_Mutation_p.L82S|FRG1B_ENST00000439954.2_Missense_Mutation_p.L87S														p.L82S(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATGGCTTTGTTGGCCTCAAAT	0.363000													6	132					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29625941	29625941	+	Missense_Mutation	SNP	A	A	T			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr20:29625941A>T	ENST00000278882.3	+	5	565	c.185A>T	c.(184-186)gAt>gTt	p.D62V	FRG1B_ENST00000358464.4_Missense_Mutation_p.D62V|FRG1B_ENST00000439954.2_Missense_Mutation_p.D67V														p.D62V(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGGCATTCAGATGCAATTGGA	0.333000													11	103					0	0	1	0	0
RPS6KA6	27330	broad.mit.edu	37	X	83359667	83359667	+	Splice_Site	SNP	T	T	A			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chrX:83359667T>A	ENST00000262752.2	-	17	1463		c.e17-2		RPS6KA6_ENST00000543399.1_Splice_Site|RPS6KA6_ENST00000495332.1_Splice_Site	NM_014496.4	NP_055311.1	Q9UK32	KS6A6_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide 6						axon guidance|central nervous system development|intracellular protein kinase cascade|synaptic transmission	cytosol|nucleoplasm	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			NS(1)|central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(7)|lung(26)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(2)	46						ATCAAAGACCTACAAAAGAAC	0.294000													10	13					0	0	1	0	0
FLNA	0	broad.mit.edu	37	X	153590696	153590696	+	Missense_Mutation	SNP	G	G	A			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chrX:153590696G>A	ENST00000422373.1	-	18	2818	c.2570C>T	c.(2569-2571)aCg>aTg	p.T857M	FLNA_ENST00000369850.3_Missense_Mutation_p.T857M|FLNA_ENST00000344736.4_Missense_Mutation_p.T857M|FLNA_ENST00000360319.4_Missense_Mutation_p.T857M	NM_001456.3	NP_001447.2	P21333	FLNA_HUMAN	filamin A, alpha	857					actin crosslink formation|actin cytoskeleton reorganization|cell junction assembly|cytoplasmic sequestering of protein|establishment of protein localization|inhibition of adenylate cyclase activity by dopamine receptor signaling pathway|negative regulation of protein catabolic process|negative regulation of sequence-specific DNA binding transcription factor activity|platelet activation|platelet degranulation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of transcription factor import into nucleus|protein localization at cell surface|protein stabilization|receptor clustering	cell cortex|cytosol|extracellular region|nucleus|plasma membrane	actin filament binding|Fc-gamma receptor I complex binding|glycoprotein binding|GTP-Ral binding|protein homodimerization activity|Rac GTPase binding|signal transducer activity|transcription factor binding			breast(6)	6	all_cancers(53;3.7e-16)|all_epithelial(53;2.97e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCTGGTGGGCGTGGCCTGCAG	0.637000													34	85					0	0	1	0	0
ICK	22858	broad.mit.edu	37	6	52884097	52884097	+	Missense_Mutation	SNP	T	T	G			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr6:52884097T>G	ENST00000356971.3	-	7	908	c.419A>C	c.(418-420)aAa>aCa	p.K140T	ICK_ENST00000350082.5_Missense_Mutation_p.K140T	NM_016513.4	NP_057597.2	Q9UPZ9	ICK_HUMAN	intestinal cell (MAK-like) kinase	140	Protein kinase.				intracellular protein kinase cascade|multicellular organismal development	cytosol|nucleus	ATP binding|cyclin-dependent protein kinase activity|magnesium ion binding			breast(1)|central_nervous_system(2)|endometrium(4)|kidney(2)|large_intestine(6)|lung(10)|ovary(1)|prostate(1)|skin(3)|stomach(1)	31	Lung NSC(77;0.103)					GTCTGCAATTTTCACAAGTTC	0.388000													8	27					0	0	1	0	0
ABCC8	6833	broad.mit.edu	37	11	17419890	17419890	+	Missense_Mutation	SNP	C	C	T			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr11:17419890C>T	ENST00000302539.4	-	30	3877	c.3752G>A	c.(3751-3753)cGa>cAa	p.R1251Q	ABCC8_ENST00000389817.3_Missense_Mutation_p.R1250Q	NM_000352.3	NP_000343.2	Q09428	ABCC8_HUMAN	ATP-binding cassette, sub-family C (CFTR/MRP), member 8	1250	ABC transmembrane type-1 2.				carbohydrate metabolic process|energy reserve metabolic process	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances|potassium ion transmembrane transporter activity|sulfonylurea receptor activity	p.R1250Q(1)		NS(1)|breast(1)|cervix(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(14)|lung(38)|ovary(1)|skin(5)|upper_aerodigestive_tract(1)|urinary_tract(1)	67				READ - Rectum adenocarcinoma(2;0.0325)|Colorectal(2;0.1)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)|Gliclazide(DB01120)|Mitiglinide(DB01252)|Nateglinide(DB00731)|Repaglinide(DB00912)	ACTTGCCATTCGGACTTCCAG	0.542000													24	17					0	0	1	0	0
KIR2DL1	3802	broad.mit.edu	37	19	55284834	55284834	+	Silent	SNP	A	A	G			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr19:55284834A>G	ENST00000336077.6	+	3	160	c.120A>G	c.(118-120)aaA>aaG	p.K40K	KIR3DL1_ENST00000538269.1_Intron|KIR3DL1_ENST00000541392.1_Intron|CTB-61M7.1_ENST00000400864.3_RNA|KIR2DL1_ENST00000291633.7_Silent_p.K40K|KIR2DL3_ENST00000434419.2_Intron|KIR3DL1_ENST00000402254.2_Intron|KIR2DL4_ENST00000396284.2_Intron	NM_014218.2	NP_055033.2	P43626	KI2L1_HUMAN	killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1	40					immune response|natural killer cell inhibitory signaling pathway	integral to plasma membrane	protein binding|receptor activity			breast(3)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(5)|lung(6)|prostate(1)|skin(1)	17				GBM - Glioblastoma multiforme(193;0.0192)		GCCTGGTGAAATCAGAAGAGA	0.493000													6	222					0	0	1	0	0
MTNR1A	4543	broad.mit.edu	37	4	187455100	187455100	+	Missense_Mutation	SNP	C	C	T	rs148793802		TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr4:187455100C>T	ENST00000307161.5	-	2	997	c.796G>A	c.(796-798)Gcc>Acc	p.A266T	RP11-215A19.2_ENST00000509111.1_Intron	NM_005958.3	NP_005949.1	P48039	MTR1A_HUMAN	melatonin receptor 1A	266					circadian rhythm|G-protein signaling, coupled to cyclic nucleotide second messenger|mating behavior	integral to plasma membrane	melatonin receptor activity			breast(1)|central_nervous_system(1)|endometrium(3)|large_intestine(1)|lung(4)|ovary(1)|pancreas(1)|prostate(1)|skin(1)	14		all_cancers(14;6.39e-56)|all_epithelial(14;1.48e-41)|all_lung(41;2.45e-15)|Lung NSC(41;7.26e-15)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00335)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|Renal(120;0.0183)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;7.63e-12)|BRCA - Breast invasive adenocarcinoma(30;6.68e-07)|GBM - Glioblastoma multiforme(59;3.44e-05)|LUSC - Lung squamous cell carcinoma(40;0.000106)|STAD - Stomach adenocarcinoma(60;0.000279)|READ - Rectum adenocarcinoma(43;0.159)	Melatonin(DB01065)|Ramelteon(DB00980)	ACCATGCTGGCGGGGTCAGAG	0.507000													39	49					0	0	1	0	0
TREX2	11219	broad.mit.edu	37	X	152710335	152710335	+	Missense_Mutation	SNP	C	C	T			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chrX:152710335C>T	ENST00000330912.2	-	13	2104	c.554G>A	c.(553-555)aGc>aAc	p.S185N	TREX2_ENST00000370231.2_Missense_Mutation_p.S185N|TREX2_ENST00000393862.2_Missense_Mutation_p.S185N|TREX2_ENST00000370232.1_Missense_Mutation_p.S228N|TREX2_ENST00000414588.1_Missense_Mutation_p.S227N|TREX2_ENST00000338525.2_Missense_Mutation_p.S185N|TREX2_ENST00000334497.2_Missense_Mutation_p.S228N|TREX2_ENST00000402951.1_Missense_Mutation_p.S228N			Q9BQ50	TREX2_HUMAN	three prime repair exonuclease 2	228					DNA repair	nucleus	3'-5'-exodeoxyribonuclease activity|exodeoxyribonuclease III activity|nucleic acid binding			endometrium(4)|large_intestine(2)|lung(3)|ovary(2)	11	all_hematologic(71;4.25e-06)|Acute lymphoblastic leukemia(192;6.56e-05)					GTGGGCTGCGCTTGGCTCTGC	0.736000								Editing and processing nucleases					12	4					0	0	1	0	0
ZNF473	25888	broad.mit.edu	37	19	50549834	50549834	+	Missense_Mutation	SNP	C	C	T			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr19:50549834C>T	ENST00000595661.1	+	6	2629	c.2134C>T	c.(2134-2136)Cgt>Tgt	p.R712C	ZNF473_ENST00000445728.3_Missense_Mutation_p.R700C|ZNF473_ENST00000270617.3_Missense_Mutation_p.R712C|ZNF473_ENST00000391821.2_Missense_Mutation_p.R712C|ZNF473_ENST00000601364.1_Intron|CTD-2126E3.3_ENST00000599410.1_RNA|CTD-2126E3.3_ENST00000599914.1_RNA			Q8WTR7	ZN473_HUMAN	zinc finger protein 473	712					histone mRNA 3'-end processing|regulation of transcription, DNA-dependent|termination of RNA polymerase II transcription	Cajal body	DNA binding|protein binding|zinc ion binding			NS(1)|breast(2)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(9)|liver(2)|lung(12)|ovary(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	37		all_neural(266;0.0459)|Ovarian(192;0.0728)		GBM - Glioblastoma multiforme(134;0.00111)|OV - Ovarian serous cystadenocarcinoma(262;0.0058)		GAAAACGTTCCGTCAGAGCTC	0.502000													28	53					0	0	1	0	0
TUFM	7284	broad.mit.edu	37	16	28855116	28855116	+	Missense_Mutation	SNP	G	G	T			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr16:28855116G>T	ENST00000313511.3	-	9	1273	c.1135C>A	c.(1135-1137)Cct>Act	p.P379T		NM_003321.4	NP_003312.3	P49411	EFTU_HUMAN	Tu translation elongation factor, mitochondrial	376						mitochondrial nucleoid	GTP binding|GTPase activity|protein binding|translation elongation factor activity			breast(1)|endometrium(2)|kidney(1)|large_intestine(3)|lung(4)|ovary(1)|prostate(1)	13						AACATGACAGGCATGAAGTGG	0.577000													14	19					9.31168e-06	1.00877e-05	1	1	0
CLEC12A	160364	broad.mit.edu	37	12	10132100	10132100	+	Missense_Mutation	SNP	G	G	A			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr12:10132100G>A	ENST00000304361.4	+	3	538	c.356G>A	c.(355-357)cGt>cAt	p.R119H	CLEC12A_ENST00000434319.2_Missense_Mutation_p.R119H|CLEC12A_ENST00000355690.4_Missense_Mutation_p.R129H|CLEC12A_ENST00000350667.4_Missense_Mutation_p.R86H	NM_138337.5|NM_201623.3	NP_612210.4|NP_963917.2	Q5QGZ9	CL12A_HUMAN	C-type lectin domain family 12, member A	119						integral to membrane|plasma membrane	receptor activity|sugar binding			breast(1)|endometrium(1)|kidney(3)|large_intestine(2)|lung(6)|skin(2)|upper_aerodigestive_tract(1)	16						AAATTATGTCGTGAGCTATAT	0.343000													14	9					0	0	1	0	0
PRAMEF11	440560	broad.mit.edu	37	1	12887612	12887612	+	Missense_Mutation	SNP	T	T	C	rs60558629		TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr1:12887612T>C	ENST00000535591.1	-	3	440	c.245A>G	c.(244-246)cAt>cGt	p.H82R		NM_001146344.1	NP_001139816.1	O60813	PRA11_HUMAN	PRAME family member 11	82								p.H82R(1)		NS(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|lung(7)|pancreas(2)|skin(4)|urinary_tract(1)	27						GAAGCACCCATGGGCCATAGC	0.488000													5	204					0	0	1	0	0
NRD1	4898	broad.mit.edu	37	1	52258048	52258048	+	Splice_Site	SNP	C	C	A			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr1:52258048C>A	ENST00000354831.7	-	27	3217		c.e27+1		NRD1_ENST00000352171.7_Splice_Site|NRD1_ENST00000539524.1_Splice_Site|NRD1_ENST00000485608.1_Splice_Site	NM_002525.2	NP_002516.2	O43847	NRDC_HUMAN	nardilysin (N-arginine dibasic convertase)						cell migration|cell proliferation|neuromuscular junction development|positive regulation of membrane protein ectodomain proteolysis|proteolysis|regulation of endopeptidase activity	cell surface|cytosol	epidermal growth factor binding|metalloendopeptidase activity|zinc ion binding			NS(1)|breast(2)|cervix(1)|endometrium(4)|kidney(1)|large_intestine(6)|lung(9)|pancreas(1)|prostate(1)|skin(1)	27						TATGCACTTACCACAAGCAGC	0.502000													14	23					1.15088e-07	1.30912e-07	1	1	0
PCSK9	255738	broad.mit.edu	37	1	55527145	55527145	+	Silent	SNP	G	G	A			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr1:55527145G>A	ENST00000302118.5	+	11	2069	c.1779G>A	c.(1777-1779)gaG>gaA	p.E593E	PCSK9_ENST00000490692.1_3'UTR|PCSK9_ENST00000543384.1_3'UTR	NM_174936.3	NP_777596.2	Q8NBP7	PCSK9_HUMAN	proprotein convertase subtilisin/kexin type 9	593					cellular response to insulin stimulus|cellular response to starvation|cholesterol homeostasis|cholesterol metabolic process|kidney development|liver development|low-density lipoprotein particle receptor catabolic process|lysosomal transport|negative regulation of catalytic activity|negative regulation of low-density lipoprotein particle clearance|negative regulation of receptor recycling|neuron differentiation|positive regulation of neuron apoptosis|positive regulation of receptor internalization|protein autoprocessing|regulation of receptor activity	extracellular space|late endosome|lysosome|perinuclear region of cytoplasm	apolipoprotein receptor binding|identical protein binding|low-density lipoprotein particle receptor binding|serine-type endopeptidase activity|very-low-density lipoprotein particle receptor binding			NS(2)|breast(2)|central_nervous_system(3)|endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(5)|large_intestine(1)|liver(2)|lung(4)|ovary(3)|prostate(3)|skin(1)|urinary_tract(1)	32						GCCACAGGGAGGCCAGCATCC	0.652000													9	8					0	0	1	0	0
AC226119.5	0	broad.mit.edu	37	4	3952899	3952899	+	RNA	SNP	A	A	T	rs17410906		TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr4:3952899A>T	ENST00000281228.8	-	0	208				FAM86EP_ENST00000313946.8_RNA																							AGCACCGGGCATACTTGACTG	0.557000													4	36					0	0	1	0	0
ZNF142	7701	broad.mit.edu	37	2	219508021	219508021	+	Missense_Mutation	SNP	T	T	C			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr2:219508021T>C	ENST00000411696.2	-	7	3997	c.3218A>G	c.(3217-3219)aAt>aGt	p.N1073S	ZNF142_ENST00000449707.1_Missense_Mutation_p.N1073S			P52746	ZN142_HUMAN	zinc finger protein 142	1073					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(7)|endometrium(7)|large_intestine(5)|lung(12)|ovary(2)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	38		Renal(207;0.0474)		Epithelial(149;5.21e-07)|all cancers(144;0.000106)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00948)		AGAGTCCCCATTGCTCAACGG	0.602000													11	50					0	0	1	0	0
SCN3A	6328	broad.mit.edu	37	2	166019317	166019317	+	Missense_Mutation	SNP	G	G	A			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr2:166019317G>A	ENST00000360093.3	-	8	1207	c.716C>T	c.(715-717)gCc>gTc	p.A239V	SCN3A_ENST00000283254.7_Missense_Mutation_p.A239V|SCN3A_ENST00000409101.3_Missense_Mutation_p.A239V	NM_001081677.1	NP_001075146.1	Q9NY46	SCN3A_HUMAN	sodium channel, voltage-gated, type III, alpha subunit	239						voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(1)|breast(7)|central_nervous_system(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(19)|liver(2)|lung(47)|ovary(6)|prostate(3)|skin(10)|upper_aerodigestive_tract(4)|urinary_tract(3)	120					Lamotrigine(DB00555)	CTGGATCAGGGCCCCCACAAT	0.453000													39	80					0	0	1	0	0
SLC12A7	10723	broad.mit.edu	37	5	1093658	1093658	+	Missense_Mutation	SNP	C	C	A			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr5:1093658C>A	ENST00000264930.5	-	3	375	c.332G>T	c.(331-333)cGg>cTg	p.R111L		NM_006598.2	NP_006589.2	Q9Y666	S12A7_HUMAN	solute carrier family 12 (potassium/chloride transporter), member 7	111					potassium ion transport|sodium ion transport	integral to plasma membrane	potassium:chloride symporter activity			breast(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(14)|ovary(2)|prostate(1)|skin(4)|urinary_tract(2)	32	Lung NSC(6;2.47e-13)|all_lung(6;1.67e-12)|all_epithelial(6;5.44e-09)		Epithelial(17;0.000497)|OV - Ovarian serous cystadenocarcinoma(19;0.00239)|all cancers(22;0.00241)|Lung(60;0.165)		Potassium Chloride(DB00761)	CTTGGCCTCCCGCCGCCGGCT	0.662000													4	1					0.00909568	0.00930008	1	1	0
IL2	3558	broad.mit.edu	37	4	123374885	123374885	+	Missense_Mutation	SNP	C	C	T			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr4:123374885C>T	ENST00000226730.4	-	3	615	c.331G>A	c.(331-333)Gta>Ata	p.V111I		NM_000586.3	NP_000577.2	P60568	IL2_HUMAN	interleukin 2	111					anti-apoptosis|cell adhesion|cell-cell signaling|immune response|natural killer cell activation|negative regulation of B cell apoptosis|positive regulation of activated T cell proliferation|positive regulation of B cell proliferation|positive regulation of cell growth|positive regulation of interleukin-17 production|positive regulation of tyrosine phosphorylation of Stat5 protein|T cell differentiation	extracellular space	cytokine activity|growth factor activity|interleukin-2 receptor binding|kinase activator activity	p.V111L(1)		endometrium(2)|large_intestine(4)|lung(6)|skin(1)	13				LUSC - Lung squamous cell carcinoma(721;0.185)		AGAACTATTACGTTGATATTG	0.353000			T	TNFRSF17	intestinal T-cell lymphoma								16	18					0	0	1	0	0
EFCAB2	84288	broad.mit.edu	37	1	245246946	245246946	+	Missense_Mutation	SNP	G	G	T			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr1:245246946G>T	ENST00000366522.2	+	7	878	c.737G>T	c.(736-738)gGg>gTg	p.G246V	EFCAB2_ENST00000487845.1_3'UTR|EFCAB2_ENST00000447569.2_Missense_Mutation_p.G110V|EFCAB2_ENST00000366523.1_Missense_Mutation_p.G110V			Q5VUJ9	EFCB2_HUMAN	EF-hand calcium binding domain 2	246	EF-hand 2.						calcium ion binding			breast(1)|endometrium(2)|kidney(1)|large_intestine(2)|lung(4)|prostate(1)|stomach(2)	13	all_cancers(71;2.93e-06)|all_epithelial(71;2.13e-05)|all_lung(81;0.0337)|Lung NSC(105;0.0472)|Ovarian(71;0.0584)|Breast(184;0.0716)|all_neural(11;0.0982)		OV - Ovarian serous cystadenocarcinoma(106;0.015)			GCTAAACGTGGGTTTCTTACT	0.294000													4	2					0.00024832	0.000265848	1	1	0
CSTF2	1478	broad.mit.edu	37	X	100079128	100079128	+	Missense_Mutation	SNP	C	C	A			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chrX:100079128C>A	ENST00000415585.2	+	6	606	c.584C>A	c.(583-585)aCa>aAa	p.T195K	CSTF2_ENST00000372972.2_Missense_Mutation_p.T195K|CSTF2_ENST00000486615.1_Intron			P33240	CSTF2_HUMAN	cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa	195	Interactions with CSTF3 and SYMPK.				mRNA cleavage|mRNA polyadenylation|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	cleavage body|mRNA cleavage and polyadenylation specificity factor complex	nucleotide binding|protein binding|RNA binding			central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(6)|skin(2)|stomach(1)	13						CATCGCCAGACAAATATCCCA	0.473000													30	84					2.80507e-11	3.23116e-11	1	1	0
MRC2	9902	broad.mit.edu	37	17	60758178	60758178	+	Missense_Mutation	SNP	C	C	T			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr17:60758178C>T	ENST00000303375.5	+	17	2893	c.2491C>T	c.(2491-2493)Cgc>Tgc	p.R831C		NM_006039.4	NP_006030.2	Q9UBG0	MRC2_HUMAN	mannose receptor, C type 2	831					endocytosis	integral to membrane	receptor activity|sugar binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(2)|kidney(2)|large_intestine(11)|lung(28)|ovary(2)|prostate(1)|skin(3)	53						GGAATGGCTGCGCTTCCAGGA	0.726000													13	39					0	0	1	0	0
NHS	4810	broad.mit.edu	37	X	17750472	17750472	+	Missense_Mutation	SNP	A	A	G			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chrX:17750472A>G	ENST00000380060.3	+	8	5119	c.4781A>G	c.(4780-4782)tAc>tGc	p.Y1594C	NHS_ENST00000398097.3_Missense_Mutation_p.Y1438C	NM_198270.2	NP_938011.1	Q6T4R5	NHS_HUMAN	Nance-Horan syndrome (congenital cataracts and dental anomalies)	1594						nucleus				breast(5)|central_nervous_system(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(17)|liver(1)|lung(26)|ovary(2)|prostate(1)|skin(3)|stomach(1)|upper_aerodigestive_tract(1)	71	Hepatocellular(33;0.183)					AGCAGCCGCTACAGTGTCCGC	0.592000													64	50					0	0	1	0	0
RNMT	8731	broad.mit.edu	37	18	13741541	13741541	+	Silent	SNP	A	A	G			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr18:13741541A>G	ENST00000383314.2	+	7	1065	c.825A>G	c.(823-825)caA>caG	p.Q275Q	RNMT_ENST00000589866.1_Silent_p.Q275Q|RNMT_ENST00000543302.2_Silent_p.Q275Q|RNMT_ENST00000535051.1_Silent_p.Q33Q|RNMT_ENST00000592764.1_Silent_p.Q275Q|RNMT_ENST00000262173.3_Silent_p.Q275Q			O43148	MCES_HUMAN	RNA (guanine-7-) methyltransferase	275					mRNA capping|transcription from RNA polymerase II promoter|viral reproduction	nucleoplasm	mRNA (guanine-N7-)-methyltransferase activity|RNA binding			central_nervous_system(1)|cervix(1)|endometrium(2)|kidney(1)|large_intestine(4)|lung(7)|skin(2)	18						GTGACCCACAAATGTGTTTTG	0.348000													11	31					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29628245	29628245	+	Missense_Mutation	SNP	G	G	A			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr20:29628245G>A	ENST00000278882.3	+	6	627	c.247G>A	c.(247-249)Gcc>Acc	p.A83T	FRG1B_ENST00000358464.4_Missense_Mutation_p.A83T|FRG1B_ENST00000439954.2_Missense_Mutation_p.A88T														p.A83T(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						GGCTTTGTTGGCCTCAAATAG	0.353000													6	131					0	0	1	0	0
SCN11A	11280	broad.mit.edu	37	3	38949535	38949535	+	Missense_Mutation	SNP	G	G	C			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr3:38949535G>C	ENST00000302328.3	-	10	1576	c.1378C>G	c.(1378-1380)Ctc>Gtc	p.L460V	SCN11A_ENST00000456224.3_Missense_Mutation_p.L460V|SCN11A_ENST00000444237.2_Missense_Mutation_p.L460V|SCN11A_ENST00000450244.1_Missense_Mutation_p.L460V	NM_014139.2	NP_054858.2	Q9UI33	SCNBA_HUMAN	sodium channel, voltage-gated, type XI, alpha subunit	460					response to drug	voltage-gated sodium channel complex	voltage-gated sodium channel activity			NS(3)|biliary_tract(1)|breast(4)|cervix(2)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(29)|lung(29)|ovary(3)|pancreas(2)|prostate(12)|skin(14)|upper_aerodigestive_tract(5)|urinary_tract(3)	119				Kidney(284;0.00202)|KIRC - Kidney renal clear cell carcinoma(284;0.00226)	Cocaine(DB00907)	TTACCAAAGAGCTTTCTCTTT	0.393000													32	42					0	0	1	0	0
ASTN1	460	broad.mit.edu	37	1	176838076	176838076	+	Missense_Mutation	SNP	C	C	A			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr1:176838076C>A	ENST00000367654.2	-	22	3588	c.3575G>T	c.(3574-3576)gGt>gTt	p.G1192V	ASTN1_ENST00000367657.3_Missense_Mutation_p.G1184V|ASTN1_ENST00000424564.2_Missense_Mutation_p.G1184V|ASTN1_ENST00000361833.2_Missense_Mutation_p.G1184V			O14525	ASTN1_HUMAN	astrotactin 1	1192					cell migration|neuron cell-cell adhesion	integral to membrane				NS(4)|breast(5)|central_nervous_system(2)|cervix(2)|endometrium(7)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(23)|liver(1)|lung(81)|ovary(6)|prostate(5)|skin(10)|urinary_tract(3)	153						GGTGGGGGAACCCAGATCCAG	0.512000													29	46					8.58068e-18	1.00108e-17	1	1	0
OSTN	344901	broad.mit.edu	37	3	190967905	190967905	+	Missense_Mutation	SNP	G	G	A			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr3:190967905G>A	ENST00000339051.1	+	3	397	c.397G>A	c.(397-399)Ggc>Agc	p.G133S	OSTN_ENST00000445281.1_Intron	NM_198184.1	NP_937827.1	P61366	OSTN_HUMAN	osteocrin	133					cell differentiation|multicellular organismal development|ossification		hormone activity			kidney(1)|large_intestine(3)|lung(6)|pancreas(1)|skin(2)	13	all_cancers(143;6.79e-09)|Ovarian(172;0.103)		LUSC - Lung squamous cell carcinoma(58;2.42e-06)|Lung(62;2.86e-06)	GBM - Glioblastoma multiforme(46;0.000254)		AAATTCCAGAGGCTAATTGAT	0.368000													43	60					0	0	1	0	0
AKAP8L	26993	broad.mit.edu	37	19	15512057	15512057	+	Silent	SNP	G	G	A			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr19:15512057G>A	ENST00000397410.4	-	5	784	c.720C>T	c.(718-720)ggC>ggT	p.G240G	AKAP8L_ENST00000595136.1_5'UTR|AKAP8L_ENST00000595465.1_Silent_p.G179G	NM_014371.2	NP_055186.2	Q9ULX6	AKP8L_HUMAN	A kinase (PRKA) anchor protein 8-like	240						cytoplasm|nuclear matrix	DEAD/H-box RNA helicase binding|DNA binding|zinc ion binding			central_nervous_system(1)|endometrium(4)|kidney(2)|lung(1)|ovary(1)|prostate(1)|urinary_tract(1)	11						CCGGGAAGGCGCCCCCACCTC	0.642000													60	79					0	0	1	0	0
GALC	2581	broad.mit.edu	37	14	88411975	88411975	+	Missense_Mutation	SNP	C	C	T			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr14:88411975C>T	ENST00000261304.2	-	14	1698	c.1592G>A	c.(1591-1593)cGc>cAc	p.R531H	GALC_ENST00000393568.4_Missense_Mutation_p.R508H|GALC_ENST00000393569.2_Missense_Mutation_p.R505H|GALC_ENST00000544807.2_Missense_Mutation_p.R475H	NM_000153.3|NM_001201401.1	NP_000144.2|NP_001188330.1	P54803	GALC_HUMAN	galactosylceramidase	531			R -> C (in GLD).|R -> H (in GLD; infantile; significant reduction of activity).		carbohydrate metabolic process|galactosylceramide catabolic process	lysosome	cation binding|galactosylceramidase activity			endometrium(2)|kidney(2)|large_intestine(1)|lung(10)|ovary(1)|prostate(1)|stomach(2)|upper_aerodigestive_tract(1)|urinary_tract(1)	21						GAGAACTTGGCGTAGCGTGAA	0.408000													24	28					0	0	1	0	0
AC008103.5	0	broad.mit.edu	37	22	18846113	18846113	+	RNA	SNP	C	C	T			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr22:18846113C>T	ENST00000412938.1	+	0	3471																											ATCTCCTCCACGCACTGGCGC	0.612000													5	13					0	0	1	0	0
ANKRD20A8P	0	broad.mit.edu	37	2	95522772	95522772	+	RNA	SNP	T	T	C			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr2:95522772T>C	ENST00000432432.2	-	0	255					NR_040113.1													p.E49G(1)									GCGCTCCACCTCCGCGGCGTC	0.682000													4	71					0	0	1	0	0
ZNF615	284370	broad.mit.edu	37	19	52496399	52496399	+	Nonsense_Mutation	SNP	G	G	A			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr19:52496399G>A	ENST00000602063.1	-	6	2279	c.1930C>T	c.(1930-1932)Cga>Tga	p.R644*	ZNF615_ENST00000376716.5_Nonsense_Mutation_p.R644*|ZNF615_ENST00000594083.1_Nonsense_Mutation_p.R655*|ZNF615_ENST00000391795.3_Nonsense_Mutation_p.R649*|ZNF615_ENST00000598071.1_Nonsense_Mutation_p.R655*			Q8N8J6	ZN615_HUMAN	zinc finger protein 615	644					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			NS(1)|breast(1)|central_nervous_system(1)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(10)|lung(12)|ovary(5)|prostate(1)|skin(1)|stomach(3)|upper_aerodigestive_tract(2)	42		all_neural(266;0.117)		GBM - Glioblastoma multiforme(134;0.00142)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		GTGTGAAATCGCTGATGTTGT	0.383000													89	44					0	0	1	0	0
AC226119.5	0	broad.mit.edu	37	4	3952901	3952901	+	RNA	SNP	A	A	T			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr4:3952901A>T	ENST00000281228.8	-	0	206				FAM86EP_ENST00000313946.8_RNA																							CACCGGGCATACTTGACTGAC	0.552000													4	36					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29625885	29625885	+	Missense_Mutation	SNP	A	A	T			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr20:29625885A>T	ENST00000278882.3	+	5	509	c.129A>T	c.(127-129)aaA>aaT	p.K43N	FRG1B_ENST00000358464.4_Missense_Mutation_p.K43N|FRG1B_ENST00000439954.2_Missense_Mutation_p.K48N														p.K43N(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						TCGCCCTGAAATCTGGCTATG	0.353000													6	94					0	0	1	0	0
FABP7	2173	broad.mit.edu	37	6	123102370	123102370	+	Missense_Mutation	SNP	G	G	T			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr6:123102370G>T	ENST00000356535.4	+	3	415	c.379G>T	c.(379-381)Gtt>Ttt	p.V127F	FABP7_ENST00000368444.3_Intron			O15540	FABP7_HUMAN	fatty acid binding protein 7, brain	0	Fatty acid binding.				negative regulation of cell proliferation	cytoplasm	lipid binding|transporter activity			kidney(1)|large_intestine(1)|lung(2)|stomach(1)	5				GBM - Glioblastoma multiforme(226;0.226)	Alpha-Linolenic Acid(DB00132)|gamma-Homolinolenic acid(DB00154)|Icosapent(DB00159)	ATTCTTCCTTGTTTTTTTCTC	0.398000													3	19					1	1	1	1	0
TRIM71	131405	broad.mit.edu	37	3	32933116	32933116	+	Missense_Mutation	SNP	G	G	A			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr3:32933116G>A	ENST00000383763.4	+	4	2483	c.2420G>A	c.(2419-2421)cGc>cAc	p.R807H		NM_001039111.1	NP_001034200.1	Q2Q1W2	LIN41_HUMAN	tripartite motif containing 71, E3 ubiquitin protein ligase	807					multicellular organismal development	cytoplasm	zinc ion binding			breast(3)|endometrium(3)|kidney(1)|large_intestine(4)|lung(7)|ovary(3)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	24						CAGGAAGGGCGCATCATTGTG	0.597000													4	116					0	0	1	0	0
WASH3P	0	broad.mit.edu	37	15	102516500	102516500	+	RNA	SNP	C	C	T			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr15:102516500C>T	ENST00000557932.1	+	0	1448																				central_nervous_system(1)|endometrium(6)|kidney(11)|prostate(5)|stomach(1)|urinary_tract(1)	25						CCCCCAGACCCAGACTTGGGC	0.632000													11	29					0	0	1	0	0
TMEM132D	121256	broad.mit.edu	37	12	129822360	129822360	+	Missense_Mutation	SNP	G	G	A			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr12:129822360G>A	ENST00000422113.2	-	4	1444	c.1118C>T	c.(1117-1119)gCg>gTg	p.A373V		NM_133448.2	NP_597705.2	Q14C87	T132D_HUMAN	transmembrane protein 132D	373						integral to membrane				NS(1)|breast(6)|cervix(2)|endometrium(8)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(33)|liver(1)|lung(69)|ovary(10)|pancreas(2)|prostate(2)|skin(7)|upper_aerodigestive_tract(5)|urinary_tract(2)	152	all_neural(191;0.101)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0934)|Breast(359;0.133)		OV - Ovarian serous cystadenocarcinoma(86;0.000288)|Epithelial(86;0.0116)|all cancers(50;0.0246)		GGCGCCATCCGCACTGGAGAG	0.592000													89	13					0	0	1	0	0
SQSTM1	8878	broad.mit.edu	37	5	179251284	179251284	+	Missense_Mutation	SNP	C	C	T			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr5:179251284C>T	ENST00000389805.4	+	4	812	c.634C>T	c.(634-636)Cgt>Tgt	p.R212C	SQSTM1_ENST00000402874.3_Missense_Mutation_p.R128C|SQSTM1_ENST00000360718.5_Missense_Mutation_p.R128C|SQSTM1_ENST00000376929.3_Missense_Mutation_p.R128C|SQSTM1_ENST00000510187.1_Missense_Mutation_p.R212C	NM_003900.4	NP_003891.1	Q13501	SQSTM_HUMAN	sequestosome 1	212	Interaction with GABRR3 (By similarity).|LIM protein-binding (LB).				anti-apoptosis|apoptosis|cell differentiation|endosome transport|induction of apoptosis by extracellular signals|intracellular signal transduction|macroautophagy|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein localization|regulation of I-kappaB kinase/NF-kappaB cascade|ubiquitin-dependent protein catabolic process	cytosol|late endosome|nucleoplasm	protein kinase C binding|receptor tyrosine kinase binding|SH2 domain binding|ubiquitin binding|zinc ion binding		SQSTM1/ALK(2)	NS(1)|breast(1)|endometrium(1)|large_intestine(2)|liver(2)|lung(5)|ovary(1)	13	all_cancers(89;0.000205)|all_epithelial(37;7.15e-05)|Renal(175;0.000159)|Lung NSC(126;0.00136)|all_lung(126;0.00243)	all_cancers(40;0.0395)|Medulloblastoma(196;0.00498)|all_neural(177;0.0138)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACGTCCTCCTCGTGCAGGGGA	0.622000													19	29					0	0	1	0	0
ADCY2	108	broad.mit.edu	37	5	7709333	7709333	+	Missense_Mutation	SNP	C	C	T			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr5:7709333C>T	ENST00000338316.4	+	10	1500	c.1411C>T	c.(1411-1413)Cgg>Tgg	p.R471W	RP11-711G10.1_ENST00000514105.2_RNA|ADCY2_ENST00000537121.1_Missense_Mutation_p.R291W	NM_020546.2	NP_065433.2	Q08462	ADCY2_HUMAN	adenylate cyclase 2 (brain)	471					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding			NS(3)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(22)|lung(56)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(7)	119						GGGAGAACGACGGAGCCCCCA	0.587000													15	24					0	0	1	0	0
HIST1H3G	8355	broad.mit.edu	37	6	26271424	26271424	+	Silent	SNP	G	G	A			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr6:26271424G>A	ENST00000305910.3	-	1	188	c.189C>T	c.(187-189)atC>atT	p.I63I		NM_003534.2	NP_003525.1	P68431	H31_HUMAN	histone cluster 1, H3g	63					blood coagulation|nucleosome assembly|regulation of gene silencing|S phase	nucleoplasm|nucleosome	DNA binding|protein binding			breast(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(1)|lung(4)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)	12						GCAACTTGCGGATCAGCAGCT	0.617000													49	96					0	0	1	0	0
FRG1B	0	broad.mit.edu	37	20	29625956	29625956	+	Missense_Mutation	SNP	G	G	A	rs147809085		TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr20:29625956G>A	ENST00000278882.3	+	5	580	c.200G>A	c.(199-201)aGa>aAa	p.R67K	FRG1B_ENST00000358464.4_Missense_Mutation_p.R67K|FRG1B_ENST00000439954.2_Missense_Mutation_p.R72K														p.R67K(2)		endometrium(10)|kidney(21)|lung(3)|pancreas(1)|prostate(9)|urinary_tract(9)	53						ATTGGACCAAGAGAACAATGG	0.338000													4	99					0	0	1	0	0
LARP1B	55132	broad.mit.edu	37	4	129128488	129128488	+	Missense_Mutation	SNP	C	C	T			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr4:129128488C>T	ENST00000326639.6	+	19	2708	c.2497C>T	c.(2497-2499)Ctt>Ttt	p.L833F	LARP1B_ENST00000264584.5_Missense_Mutation_p.L774F|LARP1B_ENST00000354456.3_Missense_Mutation_p.L252F|LARP1B_ENST00000506199.1_3'UTR|LARP1B_ENST00000441387.1_3'UTR	NM_018078.2	NP_060548.2	Q659C4	LAR1B_HUMAN	La ribonucleoprotein domain family, member 1B	833							RNA binding			endometrium(6)|haematopoietic_and_lymphoid_tissue(2)|kidney(4)|large_intestine(7)|lung(11)|ovary(1)|prostate(3)	34						TGACCCAAAACTTCAGGAATA	0.313000													10	9					0	0	1	0	0
OR51E2	81285	broad.mit.edu	37	11	4703777	4703777	+	Silent	SNP	G	G	A			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr11:4703777G>A	ENST00000396950.3	-	2	404	c.165C>T	c.(163-165)caC>caT	p.H55H		NM_030774.3	NP_110401.1	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E, member 2	55					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(1)|central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(12)|ovary(2)|prostate(1)|skin(3)	23		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		ACATCGGAGCGTGCAGGCTGC	0.517000													6	77					0	0	1	0	0
PARP14	54625	broad.mit.edu	37	3	122420030	122420030	+	Missense_Mutation	SNP	G	G	A			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr3:122420030G>A	ENST00000474629.2	+	6	2895	c.2629G>A	c.(2629-2631)Gtg>Atg	p.V877M		NM_017554.2	NP_060024.2	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	877	Macro 1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			NS(2)|breast(5)|cervix(2)|endometrium(7)|kidney(5)|large_intestine(8)|lung(14)|ovary(2)|pancreas(1)|prostate(2)|skin(1)|urinary_tract(1)	50				GBM - Glioblastoma multiforme(114;0.0531)		CTACCACCACGTGATCCATGC	0.577000													10	46					0	0	1	0	0
ATP7A	538	broad.mit.edu	37	X	77298882	77298882	+	Missense_Mutation	SNP	A	A	C			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chrX:77298882A>C	ENST00000341514.6	+	21	4228	c.4073A>C	c.(4072-4074)aAt>aCt	p.N1358T	ATP7A_ENST00000350425.4_Missense_Mutation_p.N361T|ATP7A_ENST00000343533.5_Missense_Mutation_p.N1280T	NM_000052.5	NP_000043.3	Q04656	ATP7A_HUMAN	ATPase, Cu++ transporting, alpha polypeptide	1358					ATP biosynthetic process|blood vessel development|blood vessel remodeling|cartilage development|cellular copper ion homeostasis|cerebellar Purkinje cell differentiation|collagen fibril organization|copper ion import|detoxification of copper ion|dopamine metabolic process|elastic fiber assembly|elastin biosynthetic process|epinephrine metabolic process|hair follicle morphogenesis|locomotory behavior|lung alveolus development|negative regulation of metalloenzyme activity|neuroprotection|peptidyl-lysine modification|pigmentation|positive regulation of metalloenzyme activity|positive regulation of oxidoreductase activity|pyramidal neuron development|regulation of oxidative phosphorylation|removal of superoxide radicals|serotonin metabolic process|skin development|T-helper cell differentiation|tryptophan metabolic process	basolateral plasma membrane|cytosol|endoplasmic reticulum|integral to membrane|late endosome|neuron projection|neuronal cell body|perinuclear region of cytoplasm|trans-Golgi network|trans-Golgi network transport vesicle	ATP binding|copper-dependent protein binding|copper-exporting ATPase activity|superoxide dismutase copper chaperone activity			breast(4)|central_nervous_system(3)|endometrium(9)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(7)|lung(26)|pancreas(1)|prostate(1)|urinary_tract(1)	53						ATTCGGATAAATTTTGTCTTT	0.343000													32	53					0	0	1	0	0
SLC7A3	84889	broad.mit.edu	37	X	70147405	70147405	+	Missense_Mutation	SNP	C	C	T			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chrX:70147405C>T	ENST00000374299.3	-	7	1256	c.1112G>A	c.(1111-1113)cGt>cAt	p.R371H	SLC7A3_ENST00000298085.4_Missense_Mutation_p.R371H			Q8WY07	CTR3_HUMAN	solute carrier family 7 (cationic amino acid transporter, y+ system), member 3	371					cellular nitrogen compound metabolic process	integral to membrane|plasma membrane				breast(1)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(7)|liver(1)|lung(9)|ovary(1)|urinary_tract(1)	31	Renal(35;0.156)				L-Arginine(DB00125)|L-Lysine(DB00123)|L-Ornithine(DB00129)	AGCAAGTACACGGAACAGGAG	0.587000													12	30					0	0	1	0	0
SMC4	10051	broad.mit.edu	37	3	160137275	160137275	+	Missense_Mutation	SNP	G	G	C			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr3:160137275G>C	ENST00000357388.3	+	12	2252	c.1801G>C	c.(1801-1803)Gat>Cat	p.D601H	SMC4_ENST00000344722.5_Missense_Mutation_p.D601H|SMC4_ENST00000469762.1_Missense_Mutation_p.D576H|SMC4_ENST00000462787.1_Missense_Mutation_p.D601H|SMC4_ENST00000360111.2_Missense_Mutation_p.D601H|RP11-432B6.3_ENST00000483754.1_Intron	NM_001002800.1	NP_001002800.1	Q9NTJ3	SMC4_HUMAN	structural maintenance of chromosomes 4	601	Flexible hinge.				cell division|mitotic chromosome condensation	condensin complex|cytoplasm|nucleus	ATP binding|protein heterodimerization activity			breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(15)|lung(20)|ovary(1)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	48			Lung(72;0.00334)|LUSC - Lung squamous cell carcinoma(72;0.00523)			GAAAGTCCTTGATGCAATAAT	0.338000													66	39					0	0	1	0	0
MICAL1	64780	broad.mit.edu	37	6	109775014	109775014	+	Missense_Mutation	SNP	C	C	T			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr6:109775014C>T	ENST00000368952.4	-	3	640	c.350G>A	c.(349-351)cGg>cAg	p.R117Q	MICAL1_ENST00000358577.3_Missense_Mutation_p.R98Q|MICAL1_ENST00000358807.3_Missense_Mutation_p.R98Q			Q8TDZ2	MICA1_HUMAN	microtubule associated monooxygenase, calponin and LIM domain containing 1	98					cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			NS(1)|breast(3)|endometrium(6)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(6)|liver(1)|lung(7)|ovary(3)|prostate(2)|skin(2)|stomach(1)|upper_aerodigestive_tract(2)|urinary_tract(2)	40		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		CACAGCGACCCGCAGCCCGCA	0.657000													66	35					0	0	1	0	0
UMOD	7369	broad.mit.edu	37	16	20352470	20352470	+	Missense_Mutation	SNP	T	T	G			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr16:20352470T>G	ENST00000396134.2	-	8	1742	c.1619A>C	c.(1618-1620)tAt>tCt	p.Y540S	UMOD_ENST00000302509.4_Missense_Mutation_p.Y507S|UMOD_ENST00000396142.2_Missense_Mutation_p.Y507S|UMOD_ENST00000570689.1_Missense_Mutation_p.Y507S|UMOD_ENST00000570331.1_5'UTR|UMOD_ENST00000396138.4_Missense_Mutation_p.Y556S|UMOD_ENST00000424589.1_Missense_Mutation_p.Y540S	NM_001278614.1	NP_001265543.1	P07911	UROM_HUMAN	uromodulin	507	ZP.				cellular defense response|negative regulation of cell proliferation	anchored to membrane|apical plasma membrane|basolateral plasma membrane|cilium membrane|extrinsic to membrane|primary cilium|spindle pole	calcium ion binding			endometrium(5)|kidney(1)|large_intestine(7)|lung(20)|ovary(1)|skin(3)|upper_aerodigestive_tract(3)|urinary_tract(1)	41						GGGTGTGGCATAGCAGTTGGT	0.542000													16	25					0	0	1	0	0
CYP4X1	260293	broad.mit.edu	37	1	47495700	47495700	+	Silent	SNP	T	T	C			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr1:47495700T>C	ENST00000371901.3	+	2	466	c.216T>C	c.(214-216)atT>atC	p.I72I	CYP4X1_ENST00000538609.1_Silent_p.I71I	NM_178033.1	NP_828847.1	Q8N118	CP4X1_HUMAN	cytochrome P450, family 4, subfamily X, polypeptide 1	72						endoplasmic reticulum membrane|microsome	aromatase activity|electron carrier activity|heme binding			endometrium(1)|kidney(2)|large_intestine(1)|lung(7)|ovary(1)|skin(4)|upper_aerodigestive_tract(1)	17						TTGAGGAAATTATTGAAAAAT	0.418000													33	40					0	0	1	0	0
PXN	5829	broad.mit.edu	37	12	120660787	120660787	+	Missense_Mutation	SNP	C	C	G			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr12:120660787C>G	ENST00000536957.1	-	4	841	c.366G>C	c.(364-366)caG>caC	p.Q122H	PXN_ENST00000424649.2_Missense_Mutation_p.Q124H|PXN_ENST00000267257.7_Missense_Mutation_p.Q124H|PXN_ENST00000458477.2_5'UTR|PXN_ENST00000228307.7_Missense_Mutation_p.Q124H|PXN_ENST00000538144.1_5'UTR			P49023	PAXI_HUMAN	paxillin	124					cell junction assembly|cell-matrix adhesion|cellular response to reactive oxygen species|epidermal growth factor receptor signaling pathway|growth hormone receptor signaling pathway|muscle contraction|signal complex assembly	cytoplasm|focal adhesion|lamellipodium|microtubule associated complex	beta-catenin binding|vinculin binding|zinc ion binding			breast(1)|endometrium(5)|kidney(2)|large_intestine(1)|lung(5)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					CAGCTGATTTCTGCTTGTTGG	0.522000													25	28					0	0	1	0	0
C1QTNF1	114897	broad.mit.edu	37	17	77042776	77042776	+	Splice_Site	SNP	G	G	A			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr17:77042776G>A	ENST00000339142.2	+	4	850	c.295_splice	c.e4+1	p.G99_splice	C1QTNF1_ENST00000583904.1_Splice_Site_p.G99_splice|C1QTNF1_ENST00000581774.1_Splice_Site_p.G99_splice|C1QTNF1_ENST00000580454.1_Splice_Site_p.G99_splice|C1QTNF1_ENST00000580474.1_Splice_Site_p.G99_splice|C1QTNF1_ENST00000354124.3_Splice_Site_p.G109_splice|C1QTNF1_ENST00000578229.1_Splice_Site_p.G17_splice|C1QTNF1_ENST00000392445.2_Splice_Site_p.G99_splice|C1QTNF1_ENST00000311661.4_Splice_Site_p.G17_splice|C1QTNF1_ENST00000579760.1_Splice_Site_p.G99_splice	NM_198593.3	NP_940995.1	Q9BXJ1	C1QT1_HUMAN	C1q and tumor necrosis factor related protein 1	99	Collagen-like.					collagen				breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(5)|ovary(2)	14			BRCA - Breast invasive adenocarcinoma(99;0.0294)|OV - Ovarian serous cystadenocarcinoma(97;0.201)			TATCTTGAAAGGTCAGATGGC	0.627000											OREG0024791	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	60	110					0	0	1	0	0
RRP1	8568	broad.mit.edu	37	21	45217427	45217427	+	Missense_Mutation	SNP	G	G	A			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr21:45217427G>A	ENST00000497547.1	+	6	664	c.547G>A	c.(547-549)Gag>Aag	p.E183K	RRP1_ENST00000471909.1_3'UTR	NM_003683.5	NP_003674.1	P56182	RRP1_HUMAN	ribosomal RNA processing 1	183					rRNA processing	nucleolus|preribosome, small subunit precursor				central_nervous_system(1)|kidney(1)|lung(4)|stomach(2)	8				COAD - Colon adenocarcinoma(84;0.00753)|Colorectal(79;0.0157)|STAD - Stomach adenocarcinoma(101;0.171)		AGTGGGCGCCGAGGAGGTGAG	0.637000													35	34					0	0	1	0	0
BAGE2	85319	broad.mit.edu	37	21	11098920	11098920	+	RNA	SNP	A	A	G	rs78230864		TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr21:11098920A>G	ENST00000470054.1	-	0	5									B melanoma antigen family, member 2															Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		gggagataccagagaccctaa	0.572000													6	21					0	0	1	0	0
KIAA0430	9665	broad.mit.edu	37	16	15729877	15729877	+	Missense_Mutation	SNP	G	G	A			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr16:15729877G>A	ENST00000396368.3	-	3	673	c.467C>T	c.(466-468)tCt>tTt	p.S156F	KIAA0430_ENST00000548025.1_Missense_Mutation_p.S156F|KIAA0430_ENST00000602337.1_Missense_Mutation_p.S156F|KIAA0430_ENST00000540441.2_Missense_Mutation_p.S156F|KIAA0430_ENST00000344181.3_5'UTR|KIAA0430_ENST00000551742.1_Missense_Mutation_p.S156F	NM_001184998.1|NM_001184999.1|NM_014647.3	NP_001171927.1|NP_001171928.1|NP_055462.2	Q9Y4F3	LKAP_HUMAN	KIAA0430	155						peroxisome	nucleotide binding|RNA binding			breast(4)|endometrium(8)|kidney(4)|large_intestine(2)|lung(13)|ovary(3)|prostate(5)|skin(1)	40						TGAAGATGCAGACTGGAAAGC	0.512000													13	155					0	0	1	0	0
ZNF585B	92285	broad.mit.edu	37	19	37677126	37677126	+	Missense_Mutation	SNP	T	T	A			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr19:37677126T>A	ENST00000532828.2	-	5	1564	c.1313A>T	c.(1312-1314)tAt>tTt	p.Y438F	ZNF585B_ENST00000531805.1_Missense_Mutation_p.Y383F|ZNF585B_ENST00000527838.1_3'UTR|ZNF585B_ENST00000312908.5_Missense_Mutation_p.Y26F|CTC-454I21.3_ENST00000585860.2_Intron	NM_152279.3	NP_689492.3	Q52M93	Z585B_HUMAN	zinc finger protein 585B	438					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding			NS(1)|breast(3)|endometrium(1)|large_intestine(9)|lung(13)|ovary(1)|prostate(1)	29			COAD - Colon adenocarcinoma(19;0.114)|Colorectal(19;0.177)			ACCACATTTATAAGGTTTCTC	0.378000													15	169					0	0	1	0	0
FREM2	341640	broad.mit.edu	37	13	39262004	39262004	+	Missense_Mutation	SNP	G	G	T			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr13:39262004G>T	ENST00000280481.7	+	1	739	c.523G>T	c.(523-525)Gtc>Ttc	p.V175F		NM_207361.4	NP_997244.3	Q5SZK8	FREM2_HUMAN	FRAS1 related extracellular matrix protein 2	175					cell communication|homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			NS(1)|breast(2)|central_nervous_system(2)|cervix(1)|endometrium(14)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(35)|lung(39)|ovary(9)|pancreas(2)|prostate(12)|skin(11)|upper_aerodigestive_tract(7)|urinary_tract(2)	148		Lung NSC(96;1.04e-07)|Prostate(109;0.00384)|Breast(139;0.00396)|Lung SC(185;0.0565)|Hepatocellular(188;0.114)		all cancers(112;3.32e-07)|Epithelial(112;1.66e-05)|OV - Ovarian serous cystadenocarcinoma(117;0.00154)|BRCA - Breast invasive adenocarcinoma(63;0.00631)|GBM - Glioblastoma multiforme(144;0.0312)		GGTGGAGGTGGTCTTCACCCA	0.677000													5	6					0.000602214	0.000637227	1	1	0
SUSD4	55061	broad.mit.edu	37	1	223402701	223402701	+	Missense_Mutation	SNP	C	C	T			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr1:223402701C>T	ENST00000343846.3	-	5	1387	c.754G>A	c.(754-756)Gga>Aga	p.G252R	SUSD4_ENST00000478605.1_Intron|SUSD4_ENST00000454695.2_Missense_Mutation_p.G92R|SUSD4_ENST00000366878.4_Missense_Mutation_p.G252R			Q5VX71	SUSD4_HUMAN	sushi domain containing 4	252	Sushi 4.					integral to membrane				cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(5)|liver(1)|lung(5)|skin(1)	17				GBM - Glioblastoma multiforme(131;0.0611)		ACGAAATCTCCGTGACTCACC	0.532000													3	27					0	0	1	0	0
TUBGCP5	114791	broad.mit.edu	37	15	22848945	22848945	+	Missense_Mutation	SNP	T	T	C			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr15:22848945T>C	ENST00000283645.4	+	10	1122	c.992T>C	c.(991-993)aTt>aCt	p.I331T	TUBGCP5_ENST00000559846.1_3'UTR|TUBGCP5_ENST00000453949.2_Missense_Mutation_p.I331T	NM_052903.4	NP_443135.3	Q96RT8	GCP5_HUMAN	tubulin, gamma complex associated protein 5	331					G2/M transition of mitotic cell cycle|microtubule nucleation	centrosome|cytosol|gamma-tubulin ring complex|microtubule|spindle pole	microtubule binding			breast(5)|cervix(1)|endometrium(6)|kidney(1)|large_intestine(6)|lung(23)|prostate(1)|skin(2)|urinary_tract(1)	46		all_cancers(20;2.26e-25)|all_epithelial(15;2.1e-22)|Lung NSC(15;3.36e-17)|all_lung(15;1.04e-16)|Breast(32;0.000776)|Colorectal(260;0.0488)		all cancers(64;2.86e-06)|Epithelial(43;2.63e-05)|BRCA - Breast invasive adenocarcinoma(123;0.000949)		CAGGAGTTCATTGATGAAGTC	0.458000													20	21					0	0	1	0	0
NCOA6	23054	broad.mit.edu	37	20	33345744	33345744	+	Silent	SNP	C	C	T			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr20:33345744C>T	ENST00000374796.2	-	8	3377	c.807G>A	c.(805-807)caG>caA	p.Q269Q	NCOA6_ENST00000359003.2_Silent_p.Q269Q			Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	269	CREBBP-binding region.|Gln-rich.|NCOA1-binding region.|TBP/GTF2A-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding	p.Q269Q(15)		NS(2)|breast(6)|central_nervous_system(3)|cervix(1)|endometrium(9)|kidney(8)|large_intestine(16)|lung(37)|ovary(4)|prostate(5)|skin(13)|upper_aerodigestive_tract(2)|urinary_tract(1)	107						gctgctgctgctgttgttgtt	0.537000													6	125					0	0	1	0	0
GBAP1	0	broad.mit.edu	37	1	155188471	155188471	+	RNA	DEL	C	C	-			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr1:155188471delC	ENST00000486869.1	-	0	96					NR_002188.2																						TCAGGATGCTCCCCACCACTC	0.542													7	0	---	---	---	---					
ANKRD20A8P	0	broad.mit.edu	37	2	95513688	95513689	+	RNA	INS	-	-	TA			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr2:95513688_95513689insTA	ENST00000432432.2	-	0	850					NR_040113.1																						CTCACCTAATGTATAAGATGGA	0.327													9	73	---	---	---	---					
PTPN18	26469	broad.mit.edu	37	2	131129929	131129934	+	In_Frame_Del	DEL	GACGGG	GACGGG	-	rs112040677		TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr2:131129929_131129934delGACGGG	ENST00000175756.5	+	13	1214_1219	c.1113_1118delGACGGG	c.(1111-1119)cag>ca	p.QTG371del	PTPN18_ENST00000347849.3_In_Frame_Del_p.QTG264del	NM_014369.3	NP_055184.2	Q99952	PTN18_HUMAN	protein tyrosine phosphatase, non-receptor type 18 (brain-derived)	371						cytoplasm|nucleus	non-membrane spanning protein tyrosine phosphatase activity	p.T378_G379delTG(1)		endometrium(1)|kidney(3)|large_intestine(2)|lung(5)|ovary(3)|prostate(1)	15	Colorectal(110;0.1)					gtgggacgcagacggggacggggacg	0.777													8	7	---	---	---	---					
EIF4G1	1981	broad.mit.edu	37	3	184046479	184046480	+	Frame_Shift_Ins	INS	-	-	TACCTAGCGGA			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr3:184046479_184046480insTACCTAGCGGA	ENST00000342981.4	+	26	4431_4432	c.4017_4018insTACCTAGCGGA	c.(4015-4020)ctacctfs	p.P1340fs	EIF4G1_ENST00000392537.2_Frame_Shift_Ins_p.P1252fs|EIF4G1_ENST00000434061.2_Frame_Shift_Ins_p.P1144fs|EIF4G1_ENST00000435046.2_Frame_Shift_Ins_p.P1143fs|EIF2B5_ENST00000444495.1_Intron|EIF4G1_ENST00000352767.3_Frame_Shift_Ins_p.P1346fs|EIF4G1_ENST00000411531.1_Frame_Shift_Ins_p.P1300fs|EIF4G1_ENST00000414031.1_Frame_Shift_Ins_p.P1299fs|EIF4G1_ENST00000382330.3_Frame_Shift_Ins_p.P1346fs|EIF4G1_ENST00000350481.5_Frame_Shift_Ins_p.P1175fs|EIF4G1_ENST00000424196.1_Frame_Shift_Ins_p.P1346fs|EIF4G1_ENST00000441154.1_Frame_Shift_Ins_p.P1176fs|EIF4G1_ENST00000319274.6_Frame_Shift_Ins_p.P1339fs|EIF4G1_ENST00000346169.2_Frame_Shift_Ins_p.P1339fs|EIF4G1_ENST00000427845.1_Frame_Shift_Ins_p.P1253fs	NM_182917.4	NP_886553.3	Q04637	IF4G1_HUMAN	eukaryotic translation initiation factor 4 gamma, 1	1339	MI.				insulin receptor signaling pathway|interspecies interaction between organisms|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	protein binding|translation initiation factor activity	p.L1338L(1)		central_nervous_system(1)|cervix(2)|endometrium(3)|kidney(5)|large_intestine(14)|lung(41)|ovary(2)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	75	all_cancers(143;1.06e-10)|Ovarian(172;0.0339)		Epithelial(37;1.53e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			ACGTGTGGCTCTACCTAGCGGA	0.525													12	284	---	---	---	---					
PKHD1L1	93035	broad.mit.edu	37	8	110457553	110457553	+	Frame_Shift_Del	DEL	A	A	-			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr8:110457553delA	ENST00000378402.5	+	38	5559	c.5455delA	c.(5455-5457)aafs	p.K1819fs		NM_177531.4	NP_803875.2	Q86WI1	PKHL1_HUMAN	polycystic kidney and hepatic disease 1 (autosomal recessive)-like 1	1819	IPT/TIG 10.				immune response	cytosol|extracellular space|integral to membrane	receptor activity			NS(4)|breast(13)|central_nervous_system(6)|cervix(1)|endometrium(19)|kidney(17)|large_intestine(34)|lung(122)|ovary(11)|pancreas(3)|prostate(9)|skin(3)|stomach(4)|upper_aerodigestive_tract(13)|urinary_tract(4)	263			OV - Ovarian serous cystadenocarcinoma(57;9.88e-13)			GGTGGGAAGTAAAGGCTTGGC	0.478										HNSCC(38;0.096)			20	50	---	---	---	---					
CA10	56934	broad.mit.edu	37	17	50008357	50008357	+	Frame_Shift_Del	DEL	C	C	-			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr17:50008357delC	ENST00000451037.2	-	3	1212	c.272delG	c.(271-273)gcfs	p.G91fs	CA10_ENST00000285273.4_Frame_Shift_Del_p.G91fs|CA10_ENST00000340813.6_Frame_Shift_Del_p.G97fs|CA10_ENST00000442502.2_Frame_Shift_Del_p.G91fs|CA10_ENST00000570565.1_Frame_Shift_Del_p.G16fs	NM_020178.4	NP_064563.1	Q9NS85	CAH10_HUMAN	carbonic anhydrase X	91					brain development			p.G91V(1)		cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(4)|lung(21)|ovary(1)|skin(3)|stomach(2)|urinary_tract(1)	41			BRCA - Breast invasive adenocarcinoma(22;4.74e-06)			TACCTTCCTGCCCCCCGTGTT	0.493													8	406	---	---	---	---					
TK1	7083	broad.mit.edu	37	17	76171208	76171209	+	Frame_Shift_Del	DEL	CG	CG	-			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr17:76171208_76171209delCG	ENST00000588734.1	-	6	673_674	c.435_436delCG	c.(433-438)agtgfs	p.SV145fs	TK1_ENST00000590430.1_3'UTR|TK1_ENST00000405273.1_Frame_Shift_Del_p.SV145fs|TK1_ENST00000590862.1_Frame_Shift_Del_p.SV145fs|TK1_ENST00000301634.7_Frame_Shift_Del_p.SV145fs			P04183	KITH_HUMAN	thymidine kinase 1, soluble	145					DNA replication|protein homotetramerization|pyrimidine base metabolic process|pyrimidine nucleoside salvage	cytosol	ATP binding|thymidine kinase activity|zinc ion binding			endometrium(1)|large_intestine(1)|urinary_tract(2)	4			BRCA - Breast invasive adenocarcinoma(99;0.00269)|OV - Ovarian serous cystadenocarcinoma(97;0.0804)|Lung(188;0.23)			AGCTTCACCACGCTCTCGGCCA	0.614													21	80	---	---	---	---					
ARHGAP35	2909	broad.mit.edu	37	19	47424918	47424918	+	Frame_Shift_Del	DEL	T	T	-			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chr19:47424918delT	ENST00000404338.3	+	1	2986	c.2986delT	c.(2986-2988)ttfs	p.F996fs		NM_004491.4	NP_004482.4	Q9NRY4	RHG35_HUMAN	Rho GTPase activating protein 35	996					axon guidance|negative regulation of transcription, DNA-dependent|small GTPase mediated signal transduction|transcription, DNA-dependent	cytosol	DNA binding|Rho GTPase activator activity|transcription corepressor activity										TTACAGCCTGTTTCGAGAAGA	0.483													16	41	---	---	---	---					
PRKX	5613	broad.mit.edu	37	X	3631199	3631200	+	Frame_Shift_Del	DEL	GG	GG	-			TCGA-ND-A4WA-01A-12D-A28R-08	TCGA-ND-A4WA-10B-01D-A28U-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	7258a48f-d4e4-4176-a15b-375751e10e91	ee4803a3-d432-4dcd-ba69-2ccaae1eafd2	g.chrX:3631199_3631200delGG	ENST00000262848.5	-	1	449_450	c.95_96delCC	c.(94-96)cfs	p.P32fs		NM_005044.4	NP_005035.1	P51817	PRKX_HUMAN	protein kinase, X-linked	32							ATP binding|cAMP-dependent protein kinase activity			kidney(1)|large_intestine(2)|lung(6)|pancreas(1)|skin(2)	12		all_lung(23;0.000396)|Lung NSC(23;0.00123)				CCTCAGGGCTGGGGCAGAGCGC	0.757													2	4	---	---	---	---					
