Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
TNR	7143	broad.mit.edu	37	1	175334302	175334302	+	Silent	SNP	T	T	G			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr1:175334302T>G	uc001gkp.1	-	10	2512	c.2431A>C	c.(2431-2433)AGG>CGG	p.R811R	TNR_uc009wwu.1_Silent_p.R811R	NM_003285	NP_003276	Q92752	TENR_HUMAN	tenascin R precursor	811	Fibronectin type-III 6.				axon guidance|cell adhesion|signal transduction	proteinaceous extracellular matrix				pancreas(5)|ovary(4)|central_nervous_system(1)|skin(1)	11	Renal(580;0.146)					TCCTCATCCCTGGGGCTGTAG	0.522		NA											17	48					0	0	0	0
NUAK2	81788	broad.mit.edu	37	1	205290569	205290569	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr1:205290569G>A	uc001hce.2	-	1	315	c.188C>T	c.(187-189)ACC>ATC	p.T63I		NM_030952	NP_112214	Q9H093	NUAK2_HUMAN	NUAK family, SNF1-like kinase, 2	63	Protein kinase.|ATP (By similarity).				actin cytoskeleton organization|apoptosis|cellular response to glucose starvation|negative regulation of apoptosis		ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(3)|stomach(1)|breast(1)	5	Breast(84;0.186)		BRCA - Breast invasive adenocarcinoma(75;0.117)			CTTCCCGTAGGTGCCTTTGCC	0.697		NA											7	42					0	0	0	0
EFCAB4A	283229	broad.mit.edu	37	11	828915	828915	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr11:828915C>T	uc001lrv.2	+	2	607	c.229C>T	c.(229-231)CGG>TGG	p.R77W	EFCAB4A_uc010qwt.1_Missense_Mutation_p.R77W|EFCAB4A_uc009ycm.1_Missense_Mutation_p.R77W|EFCAB4A_uc001lrw.2_5'Flank			Q8N4Y2	EFC4A_HUMAN	RecName: Full=EF-hand calcium-binding domain-containing protein 4A;	77	EF-hand 2.				store-operated calcium entry		calcium ion binding				0		all_cancers(49;2.31e-08)|all_epithelial(84;3.72e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.179)|all_lung(207;0.227)		all cancers(45;1.45e-25)|Epithelial(43;1.17e-24)|OV - Ovarian serous cystadenocarcinoma(40;6.76e-19)|BRCA - Breast invasive adenocarcinoma(625;4.23e-05)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		AAGTCTGGACCGGGCTCACAC	0.657		NA											7	91					0	0	0	0
CPT1A	1374	broad.mit.edu	37	11	68548198	68548198	+	Silent	SNP	C	C	T			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr11:68548198C>T	uc001oog.3	-	12	1538	c.1368G>A	c.(1366-1368)TCG>TCA	p.S456S	CPT1A_uc001oof.3_Silent_p.S456S|CPT1A_uc009ysj.2_Intron	NM_001876	NP_001867	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A liver isoform	456	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			skin(2)	2	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	CAAACGTGAACGACTTGTCAA	0.493		NA											15	53					0	0	0	0
UCP3	7352	broad.mit.edu	37	11	73717220	73717220	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr11:73717220C>T	uc001our.2	-	3	686	c.331G>A	c.(331-333)GCG>ACG	p.A111T	UCP3_uc001ous.2_Missense_Mutation_p.A111T	NM_003356	NP_003347	P55916	UCP3_HUMAN	uncoupling protein 3 isoform UCP3L	111					mitochondrial transport|respiratory electron transport chain|respiratory gaseous exchange	integral to membrane|mitochondrial inner membrane	binding			pancreas(1)	1	Breast(11;2.08e-05)					TCACTGTCCGCGCCTTTGGGG	0.612		NA											15	34					0	0	0	0
UPF3A	65110	broad.mit.edu	37	13	115048325	115048325	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr13:115048325C>T	uc001vup.2	+	3	365	c.328C>T	c.(328-330)CTC>TTC	p.L110F	UPF3A_uc010tkn.1_Missense_Mutation_p.L110F|UPF3A_uc001vuq.2_Missense_Mutation_p.L110F|UPF3A_uc001vus.2_Intron|UPF3A_uc001vur.2_RNA	NM_023011	NP_075387	Q9H1J1	REN3A_HUMAN	UPF3 regulator of nonsense transcripts homolog A	110	Required for interaction with UPF2.				mRNA transport|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|positive regulation of translation	cytoplasm|nucleus|plasma membrane	nucleocytoplasmic transporter activity|nucleotide binding|protein binding|RNA binding			skin(1)	1	Lung NSC(43;0.00299)|all_neural(89;0.0337)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_cancers(25;0.0191)|all_epithelial(44;0.00716)|all_lung(25;0.0173)|Lung NSC(25;0.0634)|Breast(118;0.238)	BRCA - Breast invasive adenocarcinoma(86;0.0886)	OV - Ovarian serous cystadenocarcinoma(48;0.195)|Epithelial(10;0.2)		TTATCCTCATCTCTACTCAAG	0.343		NA											8	45					0	0	0	0
ZSCAN2	54993	broad.mit.edu	37	15	85165178	85165178	+	Silent	SNP	G	G	A			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr15:85165178G>A	uc002bkr.2	+	3	1978	c.1752G>A	c.(1750-1752)AAG>AAA	p.K584K	ZSCAN2_uc010bmz.1_Silent_p.K582K|ZSCAN2_uc010bna.2_Silent_p.K434K|ZSCAN2_uc010uox.1_Intron|ZSCAN2_uc010uoy.1_Intron|ZSCAN2_uc010uoz.1_Intron	NM_181877	NP_870992	Q7Z7L9	ZSCA2_HUMAN	zinc finger protein 29 isoform 1	584					cell differentiation|multicellular organismal development|spermatogenesis|viral reproduction	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|central_nervous_system(1)	2				UCEC - Uterine corpus endometrioid carcinoma (272;0.168)|all cancers(203;5.43e-22)		CTGGGGAGAAGCCCTACAAAT	0.483		NA											10	71					0	0	0	0
C15orf32	145858	broad.mit.edu	37	15	93015669	93015669	+	Silent	SNP	G	G	A			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr15:93015669G>A	uc002brc.1	+	1	763	c.291G>A	c.(289-291)CTG>CTA	p.L97L	C15orf32_uc010bod.1_RNA	NM_153040	NP_694585	Q32M92	CO032_HUMAN	hypothetical protein LOC145858	97										ovary(1)	1	Lung NSC(78;0.0893)|all_lung(78;0.125)		BRCA - Breast invasive adenocarcinoma(143;0.0493)|OV - Ovarian serous cystadenocarcinoma(32;0.125)			GTTTGATGCTGAAGCCAACAT	0.294		NA											4	75					0	0	0	0
ZNF434	54925	broad.mit.edu	37	16	3433182	3433182	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr16:3433182C>A	uc002cuz.2	-	6	1930	c.1128G>T	c.(1126-1128)CAG>CAT	p.Q376H	ZNF434_uc002cux.3_Missense_Mutation_p.Q587H|ZNF434_uc010uwx.1_Missense_Mutation_p.Q299H|ZNF434_uc002cuy.3_Missense_Mutation_p.Q299H	NM_017810	NP_060280	Q9NX65	ZN434_HUMAN	zinc finger protein 434	376	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						GGCTGGAACTCTGGTTGAAGC	0.532		NA											18	61					7.08e-05	0.000106139	1	0
TP53	7157	broad.mit.edu	37	17	7578212	7578212	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr17:7578212G>A	uc002gim.2	-	6	831	c.637C>T	c.(637-639)CGA>TGA	p.R213*	TP53_uc002gig.1_Nonsense_Mutation_p.R213*|TP53_uc002gih.2_Nonsense_Mutation_p.R213*|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Nonsense_Mutation_p.R81*|TP53_uc010cng.1_Nonsense_Mutation_p.R81*|TP53_uc002gii.1_Nonsense_Mutation_p.R81*|TP53_uc010cnh.1_Nonsense_Mutation_p.R213*|TP53_uc010cni.1_Nonsense_Mutation_p.R213*|TP53_uc002gij.2_Nonsense_Mutation_p.R213*|TP53_uc010cnj.1_Intron|TP53_uc002gin.2_Nonsense_Mutation_p.R120*|TP53_uc002gio.2_Nonsense_Mutation_p.R81*|TP53_uc010vug.1_Nonsense_Mutation_p.R174*	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	213	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		R -> L (in sporadic cancers; somatic mutation).|R -> W (in sporadic cancers; somatic mutation).|R -> Q (in LFS; germline mutation and in sporadic cancers; somatic mutation).|R -> G (in sporadic cancers; somatic mutation).|R -> P (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.R213*(186)|p.R213L(25)|p.R213Q(22)|p.R213fs*34(10)|p.0?(7)|p.R213P(5)|p.R81*(2)|p.R120*(2)|p.R213G(2)|p.K164_P219del(1)|p.D208_V216delDRNTFRHSV(1)|p.D207_R213delDDRNTFR(1)|p.T211_S215delTFRHS(1)|p.R213*33(1)|p.D208fs*1(1)|p.R213>L(1)|p.R209_R213delRNTFR(1)|p.R213fs*2(1)|p.T211fs*28(1)|p.R213_S215>X(1)|p.D207_V216del10(1)|p.R213R(1)|p.R213fs*32(1)|p.R209fs*6(1)|p.R213W(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ACACTATGTCGAAAAGTGTTT	0.532		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			16	9					0	0	0	0
ALOXE3	59344	broad.mit.edu	37	17	8000028	8000028	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr17:8000028C>T	uc010cnr.2	-	16	2423	c.2053G>A	c.(2053-2055)GAC>AAC	p.D685N	ALOXE3_uc002gka.2_Missense_Mutation_p.D841N|ALOXE3_uc010vuo.1_Missense_Mutation_p.D817N	NM_021628	NP_067641	Q9BYJ1	LOXE3_HUMAN	arachidonate lipoxygenase 3 isoform 2	685	Lipoxygenase.				leukotriene biosynthetic process		iron ion binding|lipoxygenase activity			skin(3)|lung(1)|central_nervous_system(1)	5						TCCTGGATGTCCCTTGAGATC	0.632		NA											7	138					0	0	0	0
CCL3	6348	broad.mit.edu	37	17	34416628	34416628	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr17:34416628G>A	uc002hkv.2	-	2	191	c.89C>T	c.(88-90)CCG>CTG	p.P30L		NM_002983	NP_002974	P10147	CCL3_HUMAN	chemokine (C-C motif) ligand 3	30					cell-cell signaling|cellular calcium ion homeostasis|cellular component movement|cytoskeleton organization|exocytosis|G-protein coupled receptor protein signaling pathway|immune response|inflammatory response|regulation of viral genome replication	extracellular space|soluble fraction	chemoattractant activity|chemokine activity|signal transducer activity				0		Ovarian(249;0.17)		UCEC - Uterine corpus endometrioid carcinoma (308;0.0182)		GCAGGCGGTCGGCGTGTCAGC	0.552		NA											14	147					0	0	0	0
KRT28	162605	broad.mit.edu	37	17	38950249	38950249	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr17:38950249G>A	uc002hvh.1	-	6	1094	c.1028C>T	c.(1027-1029)ACG>ATG	p.T343M		NM_181535	NP_853513	Q7Z3Y7	K1C28_HUMAN	keratin 25D	343	Rod.|Coil 2.					cytoplasm|intermediate filament	structural molecule activity			ovary(1)	1		Breast(137;0.000301)				CGCCAGCTGCGTACAGTAGTT	0.572		NA											39	154					0	0	0	0
4-Sep	5414	broad.mit.edu	37	17	56604314	56604314	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr17:56604314G>A	uc002iwm.1	-	2	214	c.86C>T	c.(85-87)ACG>ATG	p.T29M	SEPT4_uc002iwk.1_Translation_Start_Site|SEPT4_uc010wnw.1_Translation_Start_Site|SEPT4_uc002iwl.1_Translation_Start_Site|SEPT4_uc002iwn.1_Intron|SEPT4_uc002iwo.1_Missense_Mutation_p.T10M|SEPT4_uc002iwp.1_Missense_Mutation_p.T10M|SEPT4_uc010wnx.1_Missense_Mutation_p.T44M|SEPT4_uc010wny.1_Missense_Mutation_p.T21M|SEPT4_uc010dcy.1_Intron	NM_004574	NP_004565	O43236	SEPT4_HUMAN	septin 4 isoform 1	29					apoptosis|cell cycle|cytokinesis|regulation of apoptosis	cytoskeleton|mitochondrion|nucleus	GTP binding|GTPase activity|protein binding|structural molecule activity				0	Medulloblastoma(34;0.127)|all_neural(34;0.237)					TCCATCATCCGTGGTGTCCTC	0.478		NA											13	129					0	0	0	0
PIAS4	51588	broad.mit.edu	37	19	4013192	4013192	+	Missense_Mutation	SNP	C	C	T	rs2289867		TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr19:4013192C>T	uc002lzg.2	+	2	309	c.299C>T	c.(298-300)CCG>CTG	p.P100L		NM_015897	NP_056981	Q8N2W9	PIAS4_HUMAN	protein inhibitor of activated STAT, 4	100					positive regulation of protein sumoylation|transcription, DNA-dependent|Wnt receptor signaling pathway	cytoplasm|PML body	DNA binding|SUMO ligase activity|ubiquitin protein ligase binding|zinc ion binding			pancreas(1)	1				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.00461)|STAD - Stomach adenocarcinoma(1328;0.18)		CCCAGGACTCCGCTGGCAGGC	0.652		NA											5	88					0	0	0	0
CLC	1178	broad.mit.edu	37	19	40224981	40224981	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr19:40224981G>A	uc002omh.2	-	3	321	c.245C>T	c.(244-246)CCC>CTC	p.P82L		NM_001828	NP_001819	Q05315	LPPL_HUMAN	Charcot-Leyden crystal protein	82	Galectin.				lipid catabolic process|multicellular organismal development		carboxylesterase activity|lysophospholipase activity|sugar binding				0	all_cancers(60;2.99e-06)|all_lung(34;4.7e-08)|Lung NSC(34;5.46e-08)|Ovarian(47;0.06)	Renal(1328;0.000147)|Hepatocellular(1079;0.0202)|Myeloproliferative disorder(2;0.0255)	Epithelial(26;6.43e-25)|OV - Ovarian serous cystadenocarcinoma(5;1.07e-24)|all cancers(26;8.38e-23)	GBM - Glioblastoma multiforme(1328;4.97e-06)|STAD - Stomach adenocarcinoma(1328;0.00655)		ATCCTGAAAGGGCATATTCTT	0.537		NA											9	90					0	0	0	0
KIF1A	547	broad.mit.edu	37	2	241658530	241658530	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr2:241658530G>T	uc002vzy.2	-	45	4950	c.4804C>A	c.(4804-4806)CCC>ACC	p.P1602T	KIF1A_uc010fzk.2_Missense_Mutation_p.P1703T|KIF1A_uc002vzw.2_Missense_Mutation_p.P263T|KIF1A_uc002vzx.2_Missense_Mutation_p.P329T	NM_004321	NP_004312	Q12756	KIF1A_HUMAN	axonal transport of synaptic vesicles	1602	PH.				anterograde axon cargo transport	cytoplasm|microtubule|nucleus	ATP binding|microtubule motor activity			lung(1)	1		all_epithelial(40;1.35e-15)|Breast(86;2.14e-05)|Renal(207;0.00183)|Ovarian(221;0.0228)|all_lung(227;0.0295)|all_neural(83;0.0459)|Lung NSC(271;0.0942)|all_hematologic(139;0.158)|Melanoma(123;0.16)|Hepatocellular(293;0.244)		Epithelial(32;6.12e-30)|all cancers(36;3.46e-27)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-14)|Kidney(56;5e-09)|KIRC - Kidney renal clear cell carcinoma(57;5e-08)|BRCA - Breast invasive adenocarcinoma(100;5.87e-06)|Lung(119;0.00209)|LUSC - Lung squamous cell carcinoma(224;0.00902)|Colorectal(34;0.0282)|COAD - Colon adenocarcinoma(134;0.176)		TAGGCATAGGGGCGCCGCACC	0.617		NA											8	93					1.13e-05	1.71e-05	1	0
APCDD1L	164284	broad.mit.edu	37	20	57035926	57035926	+	Missense_Mutation	SNP	G	G	C			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr20:57035926G>C	uc002xze.1	-	4	1612	c.1426C>G	c.(1426-1428)CCC>GCC	p.P476A	APCDD1L_uc010zzp.1_Missense_Mutation_p.P487A	NM_153360	NP_699191	Q8NCL9	APCDL_HUMAN	adenomatosis polyposis coli down-regulated	476						integral to membrane				ovary(1)	1	Lung NSC(12;0.000856)|all_lung(29;0.0025)		BRCA - Breast invasive adenocarcinoma(13;5.6e-11)|Epithelial(14;1.67e-07)|all cancers(14;1.48e-06)			CCTGTGCTGGGGTGCTTCTGC	0.612		NA											12	55					0	0	0	0
MORC2	22880	broad.mit.edu	37	22	31328614	31328614	+	Missense_Mutation	SNP	A	A	C			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr22:31328614A>C	uc003aje.1	-	24	3843	c.2479T>G	c.(2479-2481)TCC>GCC	p.S827A		NM_014941	NP_055756	Q9Y6X9	MORC2_HUMAN	MORC family CW-type zinc finger 2	889							ATP binding|zinc ion binding			ovary(1)|pancreas(1)	2						AGGCATTCGGAAGTGGAGGGC	0.592		NA											8	62					0	0	0	0
PLXNA1	5361	broad.mit.edu	37	3	126707784	126707784	+	Missense_Mutation	SNP	G	G	T			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr3:126707784G>T	uc003ejg.2	+	1	283	c.279G>T	c.(277-279)AAG>AAT	p.K93N		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	116	Sema.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		ACGTCAACAAGCTGCTGCTGC	0.647		NA											8	55					1.13e-05	1.71e-05	1	0
UGT2B4	7363	broad.mit.edu	37	4	70355227	70355227	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr4:70355227G>A	uc003hek.3	-	3	979	c.932C>T	c.(931-933)TCG>TTG	p.S311L	UGT2B4_uc011cap.1_Missense_Mutation_p.S175L|UGT2B4_uc003hel.3_Missense_Mutation_p.S311L	NM_021139	NP_066962	P06133	UD2B4_HUMAN	UDP glucuronosyltransferase 2B4 precursor	311					estrogen catabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity			skin(2)	2						ACTGACCATCGACCCCAGAGA	0.373		NA											40	166					0	0	0	0
STC2	8614	broad.mit.edu	37	5	172755126	172755126	+	Missense_Mutation	SNP	C	C	A			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr5:172755126C>A	uc003mco.1	-	1	1381	c.71G>T	c.(70-72)GGG>GTG	p.G24V	STC2_uc003mcn.1_5'Flank	NM_003714	NP_003705	O76061	STC2_HUMAN	stanniocalcin 2 precursor	24					cell surface receptor linked signaling pathway|cell-cell signaling	extracellular region	hormone activity			skin(2)|ovary(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00229)|all_lung(126;0.004)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|Ovarian(839;0.223)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000183)			GGCGTCGGTCCCCCGCGCCGG	0.637		NA											18	78					3.33e-07	5.25e-07	1	0
SKIV2L	6499	broad.mit.edu	37	6	31928456	31928456	+	Silent	SNP	A	A	G			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr6:31928456A>G	uc003nyn.1	+	6	872	c.483A>G	c.(481-483)GAA>GAG	p.E161E	RDBP_uc003nyk.2_5'Flank|RDBP_uc011dot.1_5'Flank|RDBP_uc003nyl.1_5'Flank|RDBP_uc003nym.1_5'Flank|SKIV2L_uc011dou.1_Silent_p.E3E|SKIV2L_uc011dov.1_Intron	NM_006929	NP_008860	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like homolog	161						nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						GGATGGATGAACCCACCATAA	0.527		NA											36	127					0	0	0	0
SKIV2L	6499	broad.mit.edu	37	6	31931705	31931705	+	Silent	SNP	C	C	T			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr6:31931705C>T	uc003nyn.1	+	16	2052	c.1663C>T	c.(1663-1665)CTG>TTG	p.L555L	SKIV2L_uc011dou.1_Silent_p.L397L|SKIV2L_uc011dov.1_Silent_p.L362L	NM_006929	NP_008860	Q15477	SKIV2_HUMAN	superkiller viralicidic activity 2-like homolog	555						nucleus	ATP binding|ATP-dependent RNA helicase activity|protein binding|RNA binding			ovary(1)|large_intestine(1)|breast(1)|central_nervous_system(1)	4						CGGAGTGTACCTGTCCCTCCT	0.622		NA											66	165					0	0	0	0
SCUBE3	222663	broad.mit.edu	37	6	35209013	35209013	+	Missense_Mutation	SNP	C	C	T			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr6:35209013C>T	uc003okf.1	+	10	1171	c.1165C>T	c.(1165-1167)CGG>TGG	p.R389W	SCUBE3_uc003okg.1_Missense_Mutation_p.R388W|SCUBE3_uc003okh.1_Missense_Mutation_p.R276W	NM_152753	NP_689966	Q8IX30	SCUB3_HUMAN	signal peptide, CUB domain, EGF-like 3	389	EGF-like 9; calcium-binding (Potential).				protein heterooligomerization|protein homooligomerization	cell surface|extracellular region	calcium ion binding|protein binding			skin(1)	1						AGGCCAGGGTCGGCTGCACTG	0.582		NA									OREG0017372	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	15	99					0	0	0	0
FAM188B	84182	broad.mit.edu	37	7	30830851	30830851	+	Missense_Mutation	SNP	G	G	A			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr7:30830851G>A	uc003tbt.2	+	5	811	c.734G>A	c.(733-735)AGC>AAC	p.S245N	FAM188B_uc010kwe.2_Missense_Mutation_p.S216N	NM_032222	NP_115598	Q4G0A6	F188B_HUMAN	hypothetical protein LOC84182	245											0						CAAGAAGAGAGCCGGAAGGTC	0.547		NA											16	133					0	0	0	0
ABCA13	154664	broad.mit.edu	37	7	48390325	48390325	+	Silent	SNP	C	C	T			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr7:48390325C>T	uc003toq.2	+	30	10315	c.10290C>T	c.(10288-10290)TGC>TGT	p.C3430C	ABCA13_uc010kys.1_Silent_p.C504C|ABCA13_uc003tos.1_Silent_p.C256C	NM_152701	NP_689914	Q86UQ4	ABCAD_HUMAN	ATP binding cassette, sub-family A (ABC1),	3430					transport	integral to membrane	ATP binding|ATPase activity			ovary(5)|central_nervous_system(4)|skin(1)	10						TCTCTTCCTGCGTGGCACTGA	0.522		NA											34	70					0	0	0	0
SEMA3D	223117	broad.mit.edu	37	7	84651711	84651711	+	Silent	SNP	T	T	G			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr7:84651711T>G	uc003uic.2	-	11	1450	c.1410A>C	c.(1408-1410)GGA>GGC	p.G470G	SEMA3D_uc010led.2_Silent_p.G470G|SEMA3D_uc003uib.2_Silent_p.G109G	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	470	Sema.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						GCTTACCTGTTCCAAGAAACA	0.333		NA											20	124					0	0	0	0
ERICH1	157697	broad.mit.edu	37	8	642491	642491	+	Silent	SNP	C	C	G			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr8:642491C>G	uc003wph.2	-	3	356	c.291G>C	c.(289-291)GGG>GGC	p.G97G	ERICH1_uc011kwh.1_Silent_p.G97G|ERICH1_uc003wpe.1_Intron	NM_207332	NP_997215	Q86X53	ERIC1_HUMAN	glutamate-rich 1	97										large_intestine(2)	2		Colorectal(14;0.158)|Ovarian(12;0.17)|Myeloproliferative disorder(644;0.185)|Hepatocellular(245;0.236)		Epithelial(5;3.29e-14)|BRCA - Breast invasive adenocarcinoma(11;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(5;3.65e-06)|READ - Rectum adenocarcinoma(1;0.0325)		CTGTGTCATCCCCGCTGGAGG	0.557		NA											6	88					0	0	0	0
RUNX1T1	862	broad.mit.edu	37	8	92988161	92988161	+	Silent	SNP	G	G	A			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr8:92988161G>A	uc003yfd.2	-	9	1404	c.1320C>T	c.(1318-1320)TAC>TAT	p.Y440Y	RUNX1T1_uc003yfc.1_Silent_p.Y413Y|RUNX1T1_uc003yfe.1_Silent_p.Y403Y|RUNX1T1_uc010mao.2_Silent_p.Y413Y|RUNX1T1_uc011lgi.1_Silent_p.Y451Y|RUNX1T1_uc010man.1_Silent_p.Y65Y|RUNX1T1_uc003yfb.1_Silent_p.Y403Y	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	440					generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			CCTCTGGCACGTATCCAGACG	0.483		NA											25	143					0	0	0	0
NR6A1	2649	broad.mit.edu	37	9	127287138	127287138	+	Missense_Mutation	SNP	T	T	G			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr9:127287138T>G	uc004bor.1	-	9	1394	c.1216A>C	c.(1216-1218)ACC>CCC	p.T406P	NR6A1_uc004boq.1_Missense_Mutation_p.T401P|NR6A1_uc010mwq.1_Missense_Mutation_p.T402P	NM_033334	NP_201591	Q15406	NR6A1_HUMAN	nuclear receptor subfamily 6, group A, member 1	406					cell proliferation|negative regulation of transcription from RNA polymerase II promoter|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|spermatogenesis	transcription factor complex	protein homodimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(3)	3						GAGGCACTGGTCAGACCCCTG	0.413		NA											11	22					0	0	0	0
HRNR	388697	broad.mit.edu	37	1	152188526	152188527	+	Frame_Shift_Ins	INS	-	-	G	rs145041332		TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr1:152188526_152188527insG	uc001ezt.1	-	3	5654_5655	c.5578_5579insC	c.(5578-5580)CGAfs	p.R1860fs		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	1860	20				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGACCCATGTCGGCCACTGCTG	0.594		NA											12	793	---	---	---	---	NA	NA	NA	NA
MAPRE1	22919	broad.mit.edu	37	20	31424527	31424528	+	Frame_Shift_Del	DEL	TA	TA	-	rs142135206		TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr20:31424527_31424528delTA	uc002wyh.2	+	4	494_495	c.355_356delTA	c.(355-357)TATfs	p.Y119fs		NM_012325	NP_036457	Q15691	MARE1_HUMAN	microtubule-associated protein, RP/EB family,	119					cell division|cell proliferation|G2/M transition of mitotic cell cycle|mitotic prometaphase|negative regulation of microtubule polymerization|protein localization to microtubule	centrosome|cortical microtubule cytoskeleton|cytosol	microtubule plus-end binding|protein C-terminus binding				0						CGATGCAAACTATGATGGAAAA	0.411		NA											14	111	---	---	---	---	NA	NA	NA	NA
ZDHHC4	55146	broad.mit.edu	37	7	6621848	6621849	+	Frame_Shift_Ins	INS	-	-	T			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr7:6621848_6621849insT	uc003sqi.2	+	6	694_695	c.336_337insT	c.(334-339)CTGTTTfs	p.L112fs	ZDHHC4_uc003sqg.2_Frame_Shift_Ins_p.L112fs|ZDHHC4_uc003sql.2_Frame_Shift_Ins_p.L112fs|ZDHHC4_uc003sqh.2_Frame_Shift_Ins_p.L112fs|ZDHHC4_uc003sqj.2_Frame_Shift_Ins_p.L112fs|ZDHHC4_uc003sqk.2_Frame_Shift_Ins_p.L112fs|ZDHHC4_uc003sqm.2_Frame_Shift_Ins_p.L112fs	NM_001134388	NP_001127860	Q9NPG8	ZDHC4_HUMAN	zinc finger, DHHC-type containing 4	112_113	Helical; (Potential).					integral to membrane	acyltransferase activity|zinc ion binding			breast(1)|pancreas(1)	2		Ovarian(82;0.232)		UCEC - Uterine corpus endometrioid carcinoma (126;0.1)		GTGTAAACCTGTTTTTTTTCAC	0.45		NA											7	258	---	---	---	---	NA	NA	NA	NA
CDKN2A	1029	broad.mit.edu	37	9	21971048	21971058	+	Frame_Shift_Del	DEL	GCCGCGCCCCG	GCCGCGCCCCG	-	rs143282362		TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chr9:21971048_21971058delGCCGCGCCCCG	uc003zpk.2	-	2	512_522	c.300_310delCGGGGCGCGGC	c.(298-312)GCCGGGGCGCGGCTGfs	p.A100fs	MTAP_uc003zpi.1_Intron|CDKN2A_uc003zpj.2_3'UTR|CDKN2A_uc010miu.2_RNA|CDKN2A_uc003zpl.2_Frame_Shift_Del_p.R156fs	NM_000077	NP_000068	P42771	CD2A1_HUMAN	cyclin-dependent kinase inhibitor 2A isoform 1	100_104	ANK 3.		Missing.		cell cycle arrest|cell cycle checkpoint|G1 phase of mitotic cell cycle|G1/S transition of mitotic cell cycle|induction of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of cell-matrix adhesion|negative regulation of cyclin-dependent protein kinase activity|negative regulation of NF-kappaB transcription factor activity|positive regulation of macrophage apoptosis|positive regulation of smooth muscle cell apoptosis|Ras protein signal transduction|replicative senescence	cytosol|nucleus	cyclin-dependent protein kinase inhibitor activity|NF-kappaB binding|protein binding|protein binding|protein kinase binding	p.0?(1112)|p.?(13)|p.G101G(3)|p.A100S(3)|p.A102V(3)|p.L104fs*42(2)|p.A102A(2)|p.A102E(2)|p.A100P(2)|p.H83fs*2(2)|p.R103Q(1)|p.R103R(1)|p.T93_D105del(1)|p.A100V(1)|p.G101fs*17(1)|p.A68fs*3(1)|p.A102fs*18(1)|p.R103fs*43(1)|p.G101W(1)|p.A102P(1)|p.A102T(1)|p.A102fs*42(1)		haematopoietic_and_lymphoid_tissue(647)|skin(419)|upper_aerodigestive_tract(414)|central_nervous_system(381)|lung(325)|pancreas(244)|oesophagus(230)|urinary_tract(225)|pleura(94)|liver(91)|soft_tissue(79)|bone(77)|ovary(76)|biliary_tract(71)|stomach(46)|breast(46)|kidney(39)|NS(28)|thyroid(24)|cervix(23)|meninges(18)|genital_tract(15)|endometrium(13)|prostate(11)|autonomic_ganglia(10)|salivary_gland(10)|large_intestine(9)|adrenal_gland(6)|eye(4)|vulva(2)|small_intestine(1)	3678		all_cancers(5;0)|Acute lymphoblastic leukemia(3;0)|all_hematologic(3;0)|all_epithelial(2;2.37e-290)|Lung NSC(2;1.26e-139)|all_lung(2;4.48e-131)|Glioma(2;3.26e-60)|all_neural(2;2.1e-52)|Renal(3;1.07e-46)|Esophageal squamous(3;3.83e-46)|Melanoma(2;2.74e-34)|Breast(3;1.14e-11)|Ovarian(3;0.000128)|Hepatocellular(5;0.00162)|Colorectal(97;0.172)		all cancers(2;0)|GBM - Glioblastoma multiforme(3;0)|Lung(2;4.07e-74)|Epithelial(2;1.08e-61)|LUSC - Lung squamous cell carcinoma(2;3.82e-48)|LUAD - Lung adenocarcinoma(2;4.56e-26)|OV - Ovarian serous cystadenocarcinoma(39;7.64e-10)|BRCA - Breast invasive adenocarcinoma(2;5.01e-09)|STAD - Stomach adenocarcinoma(4;4.63e-07)|Kidney(2;5.79e-07)|KIRC - Kidney renal clear cell carcinoma(2;7.27e-07)|COAD - Colon adenocarcinoma(8;5.15e-05)		CGCACGTCCAGCCGCGCCCCGGCCCGGTGCA	0.758		17							Uveal_Melanoma_Familial|Familial_Malignant_Melanoma_and_Tumors_of_the_Nervous_System|Hereditary_Melanoma	HNSCC(2;<9.43e_08)|TSP Lung(5;3.83e-07)			7	38	---	---	---	---	NA	NA	NA	NA
ZNF185	7739	broad.mit.edu	37	X	152083334	152083334	+	Frame_Shift_Del	DEL	A	A	-			TCGA-CQ-6229-01A-11D-1912-08	TCGA-CQ-6229-10A-01D-1912-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	07e76152-9e83-42a5-9111-c39a2310a2e4	ab416480-3676-4775-92ba-fddf2deda045	g.chrX:152083334delA	uc010ntv.1	+	2	152	c.115delA	c.(115-117)AAGfs	p.K39fs	ZNF185_uc011myg.1_Frame_Shift_Del_p.K39fs|ZNF185_uc011myh.1_Frame_Shift_Del_p.K39fs|ZNF185_uc011myi.1_Frame_Shift_Del_p.K39fs|ZNF185_uc011myj.1_Frame_Shift_Del_p.K39fs|ZNF185_uc011myk.1_Frame_Shift_Del_p.K39fs	NM_007150	NP_009081	O15231	ZN185_HUMAN	zinc finger protein 185	39						cytoplasm|cytoskeleton|focal adhesion	zinc ion binding			ovary(3)	3	Acute lymphoblastic leukemia(192;6.56e-05)					GAAGGGGGACAAGAGCTGGAT	0.607		NA											2	4	---	---	---	---	NA	NA	NA	NA
