Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
CNR2	1269	broad.mit.edu	37	1	24202069	24202069	+	Silent	SNP	G	G	C			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr1:24202069G>C	uc001bif.2	-	2	166	c.39C>G	c.(37-39)TCC>TCG	p.S13S		NM_001841	NP_001832	P34972	CNR2_HUMAN	cannabinoid receptor 2 (macrophage)	13	Extracellular (Potential).				behavior|G-protein signaling, coupled to cyclic nucleotide second messenger|immune response|inflammatory response	dendrite|integral to plasma membrane|perikaryon	cannabinoid receptor activity			skin(2)|central_nervous_system(1)	3		Colorectal(325;3.46e-05)|Renal(390;0.000219)|Lung NSC(340;0.000233)|all_lung(284;0.000321)|Ovarian(437;0.00348)|Breast(348;0.00957)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;1.32e-24)|Colorectal(126;6.09e-08)|COAD - Colon adenocarcinoma(152;3.33e-06)|GBM - Glioblastoma multiforme(114;2.9e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00101)|KIRC - Kidney renal clear cell carcinoma(1967;0.00359)|STAD - Stomach adenocarcinoma(196;0.0131)|READ - Rectum adenocarcinoma(331;0.0649)|Lung(427;0.146)	Nabilone(DB00486)	AGCCATCCTTGGAGCCATTGG	0.512		NA											24	188					0	0	0	0
THRAP3	9967	broad.mit.edu	37	1	36755247	36755247	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr1:36755247G>T	uc001cae.3	+	5	1851	c.1627G>T	c.(1627-1629)GAG>TAG	p.E543*	THRAP3_uc001caf.3_Nonsense_Mutation_p.E543*|THRAP3_uc001cag.1_Nonsense_Mutation_p.E543*	NM_005119	NP_005110	Q9Y2W1	TR150_HUMAN	thyroid hormone receptor associated protein 3	543					androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ATP binding|ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(5)|lung(3)|breast(1)	9		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				AAAGACCTCTGAGAGCCGAGA	0.507		NA	T	USP6	aneurysmal bone cysts								24	198					6.13e-19	7.2e-19	1	0
PODN	127435	broad.mit.edu	37	1	53543413	53543413	+	Silent	SNP	C	C	T	rs138179023		TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr1:53543413C>T	uc001cuv.2	+	7	946	c.939C>T	c.(937-939)CGC>CGT	p.R313R	PODN_uc001cuw.2_Silent_p.R294R|PODN_uc010onr.1_Silent_p.R294R|PODN_uc010ons.1_Silent_p.R171R	NM_153703	NP_714914	Q7Z5L7	PODN_HUMAN	podocan	265	LRR 8.				negative regulation of cell migration|negative regulation of cell proliferation	cytoplasm|extracellular space|proteinaceous extracellular matrix	collagen binding			ovary(1)|pancreas(1)	2						GCAGCCTGCGCGAGCTATACC	0.612		NA											40	183					0	0	0	0
RTCD1	8634	broad.mit.edu	37	1	100736125	100736125	+	Silent	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr1:100736125C>T	uc001dtc.2	+	4	521	c.303C>T	c.(301-303)CTC>CTT	p.L101L	RTCD1_uc010ouh.1_Silent_p.L101L|RTCD1_uc001dtd.2_Silent_p.L114L	NM_003729	NP_003720	O00442	RTC1_HUMAN	RNA terminal phosphate cyclase domain 1 isoform	101					RNA processing	mitochondrion|nucleoplasm	ATP binding|protein binding|RNA binding|RNA-3'-phosphate cyclase activity				0		all_epithelial(167;0.000686)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0513)|all cancers(265;0.0902)|COAD - Colon adenocarcinoma(174;0.149)|Colorectal(144;0.169)|Lung(183;0.196)		GTGTGTGCCTCTTGATGCAGG	0.398		NA											43	289					0	0	0	0
STXBP3	6814	broad.mit.edu	37	1	109342874	109342874	+	Silent	SNP	A	A	G			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr1:109342874A>G	uc001dvy.2	+	17	1557	c.1482A>G	c.(1480-1482)GAA>GAG	p.E494E	STXBP3_uc001dvz.2_RNA	NM_007269	NP_009200	O00186	STXB3_HUMAN	syntaxin binding protein 3	494					negative regulation of calcium ion-dependent exocytosis|neutrophil degranulation|platelet aggregation|protein transport|vesicle docking involved in exocytosis	cytosol|nucleus|platelet alpha granule|specific granule|tertiary granule	syntaxin-2 binding			ovary(3)|central_nervous_system(1)	4		all_epithelial(167;0.000154)|all_lung(203;0.00026)|Lung NSC(277;0.000508)		Colorectal(144;0.0386)|Lung(183;0.104)|COAD - Colon adenocarcinoma(174;0.137)|Epithelial(280;0.231)		ATTCAAAAGAATGGCCATATT	0.343		NA											15	96					0	0	0	0
APH1A	51107	broad.mit.edu	37	1	150240393	150240393	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr1:150240393T>C	uc001ety.1	-	2	570	c.248A>G	c.(247-249)CAG>CGG	p.Q83R	APH1A_uc010pbx.1_Splice_Site_p.G38_splice|APH1A_uc001etz.1_Missense_Mutation_p.Q83R|APH1A_uc001eua.1_Missense_Mutation_p.Q83R|APH1A_uc010pby.1_Intron|APH1A_uc001eub.1_Splice_Site|APH1A_uc010pbz.1_Splice_Site	NM_001077628	NP_001071096	Q96BI3	APH1A_HUMAN	anterior pharynx defective 1 homolog A isoform	83	Helical; Name=3; (Potential).				amyloid precursor protein catabolic process|apoptosis|induction of apoptosis by extracellular signals|membrane protein ectodomain proteolysis|membrane protein intracellular domain proteolysis|nerve growth factor receptor signaling pathway|Notch receptor processing|Notch signaling pathway|positive regulation of catalytic activity|protein processing	endoplasmic reticulum membrane|Golgi cisterna membrane|integral to plasma membrane	protein binding			ovary(1)|lung(1)	2	Lung NSC(24;7.29e-29)|Breast(34;0.00211)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.161)|Colorectal(459;0.171)		LUSC - Lung squamous cell carcinoma(543;0.171)			GAACACCTCCTGTAGAAGGAC	0.552		NA											22	134					0	0	0	0
USH2A	7399	broad.mit.edu	37	1	215972260	215972260	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr1:215972260T>A	uc001hku.1	-	50	10334	c.9947A>T	c.(9946-9948)AAT>ATT	p.N3316I		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3316	Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TGGAAGGCGATTGTACACCAC	0.483		NA								HNSCC(13;0.011)			36	128					0	0	0	0
USH2A	7399	broad.mit.edu	37	1	216390860	216390860	+	Missense_Mutation	SNP	G	G	A	rs150729680	byFrequency	TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr1:216390860G>A	uc001hku.1	-	15	3413	c.3026C>T	c.(3025-3027)GCC>GTC	p.A1009V	USH2A_uc001hkv.2_Missense_Mutation_p.A1009V	NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	1009	Laminin EGF-like 10.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TTCATTCAAGGCTCCTGAGAG	0.393		NA								HNSCC(13;0.011)			9	52					0	0	0	0
MARK1	4139	broad.mit.edu	37	1	220826574	220826574	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr1:220826574G>C	uc001hmn.3	+	16	2465	c.1868G>C	c.(1867-1869)CGC>CCC	p.R623P	MARK1_uc009xdw.2_Missense_Mutation_p.R624P|MARK1_uc010pun.1_Missense_Mutation_p.R623P|MARK1_uc001hmm.3_Missense_Mutation_p.R601P	NM_018650	NP_061120	Q9P0L2	MARK1_HUMAN	MAP/microtubule affinity-regulating kinase 1	623					intracellular protein kinase cascade	cytoplasm|microtubule cytoskeleton	ATP binding|magnesium ion binding|protein serine/threonine kinase activity			ovary(4)|central_nervous_system(2)|skin(2)|stomach(1)|lung(1)	10				GBM - Glioblastoma multiforme(131;0.0407)		CGGGAGCGACGCAGCGTTGCT	0.532		NA											19	127					0	0	0	0
AGT	183	broad.mit.edu	37	1	230845931	230845931	+	Silent	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr1:230845931C>T	uc001hty.3	-	2	1174	c.666G>A	c.(664-666)CCG>CCA	p.P222P	AGT_uc009xfe.2_Silent_p.P222P|AGT_uc009xff.2_Silent_p.P194P	NM_000029	NP_000020	P01019	ANGT_HUMAN	angiotensinogen preproprotein	222					activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|blood vessel remodeling|cell-cell signaling|cellular lipid metabolic process|G-protein signaling, coupled to cGMP nucleotide second messenger|kidney development|low-density lipoprotein particle remodeling|negative regulation of nerve growth factor receptor signaling pathway|nitric oxide mediated signal transduction|positive regulation of activation of JAK2 kinase activity|positive regulation of apoptosis|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of cardiac muscle hypertrophy|positive regulation of cholesterol esterification|positive regulation of cytokine production|positive regulation of endothelial cell migration|positive regulation of epidermal growth factor receptor signaling pathway|positive regulation of fibroblast proliferation|positive regulation of inflammatory response|positive regulation of NAD(P)H oxidase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of phosphatidylinositol 3-kinase cascade|positive regulation of protein tyrosine kinase activity|positive regulation of reactive oxygen species metabolic process|positive regulation of transcription, DNA-dependent|regulation of proteolysis|regulation of renal output by angiotensin|regulation of renal sodium excretion|regulation of vasoconstriction|renin-angiotensin regulation of aldosterone production|response to muscle activity involved in regulation of muscle adaptation	extracellular space|soluble fraction	acetyltransferase activator activity|growth factor activity|hormone activity|serine-type endopeptidase inhibitor activity|type 1 angiotensin receptor binding|type 2 angiotensin receptor binding				0	Breast(184;0.0735)|Ovarian(103;0.183)	all_cancers(173;4.64e-23)|all_epithelial(177;3.61e-18)|Breast(1374;0.00093)|all_neural(198;0.0604)|Prostate(94;0.167)		GBM - Glioblastoma multiforme(131;4.4e-06)|Colorectal(1306;5.46e-06)|COAD - Colon adenocarcinoma(196;0.000256)|KIRC - Kidney renal clear cell carcinoma(1967;0.00258)	Aliskiren(DB01258)|Atorvastatin(DB01076)|Cilazapril(DB01340)|Irbesartan(DB01029)|Lisinopril(DB00722)|Ouabain(DB01092)|Simvastatin(DB00641)	CCTGCACAAACGGCTGCTTCA	0.617		NA											5	91					0	0	0	0
GREM2	64388	broad.mit.edu	37	1	240656540	240656540	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr1:240656540C>T	uc001hys.2	-	2	516	c.236G>A	c.(235-237)CGG>CAG	p.R79Q		NM_022469	NP_071914	Q9H772	GREM2_HUMAN	gremlin 2 precursor	79	CTCK.				BMP signaling pathway	extracellular space	cytokine activity				0		all_cancers(173;0.0196)	OV - Ovarian serous cystadenocarcinoma(106;0.0123)			CACCGTCTGCCGCAGCGGCTG	0.642		NA											4	29					0	0	0	0
GATA3	2625	broad.mit.edu	37	10	8100579	8100579	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr10:8100579A>G	uc001ika.2	+	3	1110	c.553A>G	c.(553-555)AAG>GAG	p.K185E	GATA3_uc001ijz.2_Missense_Mutation_p.K185E	NM_002051	NP_002042	P23771	GATA3_HUMAN	GATA binding protein 3 isoform 2	185					aortic valve morphogenesis|blood coagulation|canonical Wnt receptor signaling pathway involved in metanephric kidney development|cardiac right ventricle morphogenesis|cell fate determination|cellular response to interferon-alpha|cellular response to interleukin-4|cellular response to tumor necrosis factor|defense response|ear development|lymphocyte migration|male gonad development|mesenchymal to epithelial transition|mesonephros development|negative regulation of cell cycle|negative regulation of cell motility|negative regulation of cell proliferation involved in mesonephros development|negative regulation of endothelial cell apoptosis|negative regulation of fat cell differentiation|negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation|negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation|negative regulation of inflammatory response|negative regulation of mammary gland epithelial cell proliferation|nephric duct formation|norepinephrine biosynthetic process|pharyngeal system development|phosphatidylinositol 3-kinase cascade|positive regulation of endothelial cell migration|positive regulation of interleukin-13 secretion|positive regulation of interleukin-4 production|positive regulation of interleukin-5 secretion|positive regulation of protein kinase B signaling cascade|positive regulation of T cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription regulatory region DNA binding|positive regulation of ureteric bud formation|regulation of cellular response to X-ray|regulation of cytokine biosynthetic process|regulation of nephron tubule epithelial cell differentiation|response to estrogen stimulus|response to virus|sympathetic nervous system development|T cell receptor signaling pathway|TOR signaling cascade|ureteric bud formation|uterus development|ventricular septum development	nuclear chromatin|nucleolus|nucleoplasm	core promoter proximal region sequence-specific DNA binding|core promoter sequence-specific DNA binding|E-box binding|HMG box domain binding|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription|transcription coactivator activity|transcription factor binding|zinc ion binding			breast(17)|ovary(3)|central_nervous_system(2)	22						AGAGTGCCTCAAGTACCAGGT	0.701		NA	F|N|S		breast		HDR syndrome (HYPOPARATHYROIDISM|SENSORINEURAL DEAFNESS|AND RENAL DISEASE)						11	97					0	0	0	0
ANKRD30A	91074	broad.mit.edu	37	10	37430782	37430782	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr10:37430782C>A	uc001iza.1	+	7	888	c.789C>A	c.(787-789)AGC>AGA	p.S263R		NM_052997	NP_443723	Q9BXX3	AN30A_HUMAN	ankyrin repeat domain 30A	319						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(7)|breast(1)|skin(1)	9						CGGCTGAAAGCTTGGTGGAAA	0.483		NA											8	64					0.000274275	0.000291741	1	0
EXOSC1	51013	broad.mit.edu	37	10	99196219	99196219	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr10:99196219C>T	uc001kni.2	-	8	597	c.571G>A	c.(571-573)GAA>AAA	p.E191K	EXOSC1_uc009xvp.1_RNA	NM_016046	NP_057130	Q9Y3B2	EXOS1_HUMAN	exosomal core protein CSL4	191					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	protein binding|RNA binding				0		Renal(717;0.000147)|Colorectal(252;0.00205)|Ovarian(717;0.00965)		all cancers(201;8.29e-42)|Epithelial(162;5.7e-33)|BRCA - Breast invasive adenocarcinoma(275;0.000315)|Kidney(138;0.000832)|KIRC - Kidney renal clear cell carcinoma(50;0.00269)|STAD - Stomach adenocarcinoma(243;0.202)		TGCAAGAATTCGGGTTGTACT	0.478		NA											17	174					0	0	0	0
HRAS	3265	broad.mit.edu	37	11	534286	534286	+	Missense_Mutation	SNP	C	C	G	rs104894228		TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:534286C>G	uc001lpv.2	-	2	225	c.37G>C	c.(37-39)GGT>CGT	p.G13R	HRAS_uc010qvw.1_Missense_Mutation_p.G13R|HRAS_uc010qvx.1_Missense_Mutation_p.G13R|HRAS_uc010qvy.1_RNA	NM_005343	NP_005334	P01112	RASH_HUMAN	v-Ha-ras Harvey rat sarcoma viral oncogene	13	GTP.		G -> D (in FCSS).|G -> C (in FCSS).		activation of MAPKK activity|axon guidance|blood coagulation|cell cycle arrest|cellular senescence|epidermal growth factor receptor signaling pathway|insulin receptor signaling pathway|leukocyte migration|mitotic cell cycle G1/S transition checkpoint|negative regulation of cell proliferation|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of DNA replication|positive regulation of epithelial cell proliferation|Ras protein signal transduction|synaptic transmission	cytosol|Golgi membrane|plasma membrane	GTP binding|GTPase activity|protein C-terminus binding	p.G13R(34)|p.G13V(10)|p.G13D(9)|p.G13S(9)|p.G13C(6)|p.G13G(1)|p.G12_G13insAG(1)		urinary_tract(174)|thyroid(155)|skin(126)|upper_aerodigestive_tract(112)|soft_tissue(37)|prostate(29)|salivary_gland(24)|cervix(23)|stomach(14)|pituitary(10)|lung(9)|haematopoietic_and_lymphoid_tissue(9)|breast(6)|testis(5)|endometrium(4)|bone(3)|large_intestine(2)|oesophagus(2)|penis(2)|kidney(1)|adrenal_gland(1)|thymus(1)	749		all_cancers(49;4.37e-09)|all_epithelial(84;2.09e-06)|Breast(177;0.000162)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.0538)|all_lung(207;0.0713)		all cancers(45;7.63e-28)|Epithelial(43;7.29e-27)|OV - Ovarian serous cystadenocarcinoma(40;7.15e-21)|BRCA - Breast invasive adenocarcinoma(625;3.56e-05)|Lung(200;0.0375)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Sulindac(DB00605)	TTGCCCACACCGCCGGCGCCC	0.642		6	Mis		infrequent sarcomas|rare other types	rhadomyosarcoma|ganglioneuroblastoma|bladder			Costello_syndrome	HNSCC(11;0.0054)			8	28					0	0	0	0
MUC2	4583	broad.mit.edu	37	11	1087951	1087951	+	Silent	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:1087951C>T	uc001lsx.1	+	25	3453	c.3426C>T	c.(3424-3426)TTC>TTT	p.F1142F		NM_002457	NP_002448	Q02817	MUC2_HUMAN	mucin 2 precursor	1142						inner mucus layer|outer mucus layer	protein binding			lung(1)|breast(1)	2		all_cancers(49;1.08e-07)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.191)		BRCA - Breast invasive adenocarcinoma(625;0.000207)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)	Pranlukast(DB01411)	ACCGGAGCTTCGAGACCTGCA	0.612		NA											3	18					0	0	0	0
PGAP2	27315	broad.mit.edu	37	11	3845337	3845337	+	Silent	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:3845337C>T	uc001lys.2	+	4	699	c.573C>T	c.(571-573)CTC>CTT	p.L191L	PGAP2_uc001lyl.2_Silent_p.L148L|PGAP2_uc010qxw.1_Silent_p.L248L|PGAP2_uc010qxx.1_Missense_Mutation_p.H172Y|PGAP2_uc001lyp.3_Intron|PGAP2_uc010qxy.1_Silent_p.L187L|PGAP2_uc010qxz.1_Silent_p.L187L|PGAP2_uc001lyn.3_Missense_Mutation_p.H84Y|PGAP2_uc010qya.1_RNA|PGAP2_uc001lyr.2_Silent_p.L130L|PGAP2_uc010qyb.1_Missense_Mutation_p.H134Y|PGAP2_uc001lyt.2_5'UTR	NM_014489	NP_055304	Q9UHJ9	PGAP2_HUMAN	FGF receptor activating protein 1 isoform 1	191	Helical; (Potential).				GPI anchor biosynthetic process	endoplasmic reticulum membrane|Golgi membrane|integral to membrane	protein transporter activity				0						TGCTAGTGCTCACTTATGTCT	0.612		NA											6	38					0	0	0	0
ANO5	203859	broad.mit.edu	37	11	22249037	22249037	+	Nonsense_Mutation	SNP	G	G	T	rs140381407		TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:22249037G>T	uc001mqi.2	+	7	870	c.553G>T	c.(553-555)GAA>TAA	p.E185*	ANO5_uc001mqj.2_Nonsense_Mutation_p.E184*	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	185	Cytoplasmic (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						TCCCCATCCTGAATATTTTAC	0.463		NA											18	164					8.01e-06	8.79e-06	1	0
PAMR1	25891	broad.mit.edu	37	11	35463155	35463155	+	Missense_Mutation	SNP	G	G	A	rs149018193		TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:35463155G>A	uc001mwg.2	-	7	950	c.907C>T	c.(907-909)CGC>TGC	p.R303C	PAMR1_uc001mwf.2_Missense_Mutation_p.R320C|PAMR1_uc010rew.1_Missense_Mutation_p.R192C|PAMR1_uc010rex.1_Missense_Mutation_p.R263C	NM_001001991	NP_001001991	Q6UXH9	PAMR1_HUMAN	regeneration associated muscle protease isoform	303	Sushi 1.				proteolysis	extracellular region	serine-type endopeptidase activity			ovary(2)	2						TTAGCATGGCGTCCGTTGATA	0.468		NA											50	178					0	0	0	0
MADD	8567	broad.mit.edu	37	11	47330541	47330541	+	Silent	SNP	A	A	G			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:47330541A>G	uc001ner.1	+	26	4070	c.3879A>G	c.(3877-3879)AAA>AAG	p.K1293K	MADD_uc001neq.2_Intron|MADD_uc001nev.1_Intron|MADD_uc001nes.1_Intron|MADD_uc001net.1_Intron|MADD_uc009yln.1_Intron|MADD_uc001neu.1_Intron|MADD_uc001nex.2_Silent_p.K1293K|MADD_uc001nez.2_Intron|MADD_uc001new.2_Intron|MADD_uc009ylo.2_Silent_p.K207K	NM_003682	NP_003673	Q8WXG6	MADD_HUMAN	MAP-kinase activating death domain-containing	1293					activation of MAPK activity|apoptosis|cell surface receptor linked signaling pathway|regulation of apoptosis|regulation of cell cycle	cytoplasm|integral to membrane|plasma membrane	death receptor binding|protein kinase activator activity|Rab guanyl-nucleotide exchange factor activity			ovary(5)|skin(4)|central_nervous_system(2)	11				Lung(87;0.182)		GAAGGGACAAAGGATCCATGT	0.458		NA											36	172					0	0	0	0
OR8J3	81168	broad.mit.edu	37	11	55904306	55904306	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:55904306C>A	uc010riz.1	-	1	889	c.889G>T	c.(889-891)GTA>TTA	p.V297L		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	297	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					GCAACATTTACATCATTATTC	0.338		NA											20	141					3.99e-14	4.6e-14	1	0
OR9Q1	219956	broad.mit.edu	37	11	57947391	57947391	+	Missense_Mutation	SNP	C	C	T	rs2513718		TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:57947391C>T	uc001nmj.2	+	3	791	c.475C>T	c.(475-477)CGG>TGG	p.R159W		NM_001005212	NP_001005212	Q8NGQ5	OR9Q1_HUMAN	olfactory receptor, family 9, subfamily Q,	159	Helical; Name=4; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(21;0.222)				TGCCTTGGTGCGGACAGTCTC	0.537		NA											24	62					0	0	0	0
OR1S1	219959	broad.mit.edu	37	11	57982965	57982965	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:57982965C>T	uc010rkc.1	+	1	749	c.749C>T	c.(748-750)GCC>GTC	p.A250V		NM_001004458	NP_001004458	Q8NH92	OR1S1_HUMAN	olfactory receptor, family 1, subfamily S,	250	Helical; Name=6; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(1)	1		Breast(21;0.0589)				AAGTGGAAAGCCTTCTCCACT	0.468		NA											25	110					0	0	0	0
OR4D10	390197	broad.mit.edu	37	11	59244959	59244959	+	Silent	SNP	G	G	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:59244959G>A	uc001nnz.1	+	1	57	c.57G>A	c.(55-57)CAG>CAA	p.Q19Q		NM_001004705	NP_001004705	Q8NGI6	OR4DA_HUMAN	olfactory receptor, family 4, subfamily D,	19	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3						GCCTGACCCAGAATCGGGAAG	0.403		NA											5	162					0	0	0	0
NRXN2	9379	broad.mit.edu	37	11	64397889	64397889	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:64397889C>T	uc001oap.2	-	4	1115	c.604G>A	c.(604-606)GAG>AAG	p.E202K	NRXN2_uc001oar.2_Missense_Mutation_p.E1248K|NRXN2_uc001oas.2_Missense_Mutation_p.E1208K|NRXN2_uc001oaq.2_Missense_Mutation_p.E915K	NM_138734	NP_620063	P58401	NRX2B_HUMAN	neurexin 2 isoform beta precursor	202	Extracellular (Potential).|Laminin G-like.				cell adhesion	integral to membrane				upper_aerodigestive_tract(2)|central_nervous_system(2)|skin(2)|ovary(2)|kidney(1)|pancreas(1)	10						GGGTACCGCTCGTTGACCGGC	0.507		NA											10	60					0	0	0	0
SF1	7536	broad.mit.edu	37	11	64536792	64536792	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:64536792G>A	uc001obb.1	-	7	1059	c.682C>T	c.(682-684)CAG>TAG	p.Q228*	SF1_uc010rnm.1_5'Flank|SF1_uc010rnn.1_Nonsense_Mutation_p.Q202*|SF1_uc001oaz.1_Nonsense_Mutation_p.Q353*|SF1_uc001oba.1_Nonsense_Mutation_p.Q228*|SF1_uc001obc.1_Nonsense_Mutation_p.Q228*|SF1_uc001obd.1_Nonsense_Mutation_p.Q228*|SF1_uc001obe.1_Nonsense_Mutation_p.Q113*|SF1_uc010rno.1_Nonsense_Mutation_p.Q113*	NM_004630	NP_004621	Q15637	SF01_HUMAN	splicing factor 1 isoform 1	228					nuclear mRNA 3'-splice site recognition|regulation of transcription, DNA-dependent|transcription, DNA-dependent	ribosome|spliceosomal complex	protein binding|RNA binding|transcription corepressor activity|zinc ion binding			ovary(1)|breast(1)|skin(1)	3						TCGATACCCTGCTTCAGGATG	0.502		NA											6	121					0	0	0	0
C11orf30	56946	broad.mit.edu	37	11	76171120	76171120	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:76171120T>C	uc001oxl.2	+	6	705	c.562T>C	c.(562-564)TAT>CAT	p.Y188H	C11orf30_uc001oxk.2_3'UTR|C11orf30_uc009yuj.1_Missense_Mutation_p.Y203H|C11orf30_uc010rsa.1_Intron|C11orf30_uc001oxm.2_Missense_Mutation_p.Y189H|C11orf30_uc010rsb.1_Missense_Mutation_p.Y203H|C11orf30_uc010rsc.1_Missense_Mutation_p.Y203H|C11orf30_uc001oxn.2_Missense_Mutation_p.Y189H|C11orf30_uc010rsd.1_Missense_Mutation_p.Y202H	NM_020193	NP_064578	Q7Z589	EMSY_HUMAN	EMSY protein	188	Interaction with BRCA2.				chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(5)|skin(1)	6						AAGTACTGTTTATGTCAAAAG	0.458		NA											45	309					0	0	0	0
CNTN5	53942	broad.mit.edu	37	11	100179177	100179177	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:100179177C>G	uc001pga.2	+	21	3046	c.2707C>G	c.(2707-2709)CTA>GTA	p.L903V	CNTN5_uc001pfz.2_Missense_Mutation_p.L903V|CNTN5_uc001pgb.2_Missense_Mutation_p.L829V|CNTN5_uc010ruk.1_Missense_Mutation_p.L174V	NM_014361	NP_055176	O94779	CNTN5_HUMAN	contactin 5 isoform long	903	Fibronectin type-III 3.				cell adhesion	anchored to membrane|plasma membrane	protein binding			skin(3)|ovary(2)|pancreas(2)|breast(1)	8		all_hematologic(158;1.22e-05)|Acute lymphoblastic leukemia(157;3.81e-05)|Melanoma(852;0.219)		BRCA - Breast invasive adenocarcinoma(274;0.00146)|KIRC - Kidney renal clear cell carcinoma(183;0.156)|Kidney(183;0.196)		TAAAGAGAGTCTAGGAAGACC	0.418		NA											8	49					0	0	0	0
HTR3B	9177	broad.mit.edu	37	11	113803138	113803138	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:113803138G>A	uc001pok.2	+	5	563	c.496G>A	c.(496-498)GTC>ATC	p.V166I	HTR3B_uc001pol.2_Missense_Mutation_p.V155I	NM_006028	NP_006019	O95264	5HT3B_HUMAN	5-hydroxytryptamine (serotonin) receptor 3B	166	Extracellular (Potential).				synaptic transmission	integral to plasma membrane|postsynaptic membrane	serotonin receptor activity|serotonin-activated cation-selective channel activity				0		all_cancers(61;6.81e-18)|all_epithelial(67;6.67e-11)|all_hematologic(158;4.67e-05)|Melanoma(852;0.000316)|Acute lymphoblastic leukemia(157;0.000976)|Breast(348;0.0101)|Prostate(24;0.0154)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.04e-06)|Epithelial(105;1.98e-05)|all cancers(92;0.000201)|OV - Ovarian serous cystadenocarcinoma(223;0.151)		TCCATTTGATGTCCAGAATTG	0.428		NA											4	144					0	0	0	0
BSX	390259	broad.mit.edu	37	11	122849989	122849989	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:122849989G>A	uc010rzs.1	-	2	439	c.439C>T	c.(439-441)CTC>TTC	p.L147F		NM_001098169	NP_001091639	Q3C1V8	BSH_HUMAN	brain specific homeobox	147	Homeobox.										0		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0361)		GACAGGCTGAGGGCCGTGGCC	0.612		NA											43	119					0	0	0	0
OR6T1	219874	broad.mit.edu	37	11	123813728	123813728	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr11:123813728C>A	uc010sab.1	-	1	818	c.818G>T	c.(817-819)GGT>GTT	p.G273V		NM_001005187	NP_001005187	Q8NGN1	OR6T1_HUMAN	olfactory receptor, family 6, subfamily T,	273	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1		Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.22)		BRCA - Breast invasive adenocarcinoma(274;4.88e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0401)		GACGGAGGCACCTTTGTTGAG	0.512		NA											70	226					5.02e-34	5.93e-34	1	0
DYRK4	8798	broad.mit.edu	37	12	4721794	4721794	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr12:4721794A>T	uc001qmx.2	+	12	1391	c.1231A>T	c.(1231-1233)AGG>TGG	p.R411W	DYRK4_uc009zeh.1_Missense_Mutation_p.R526W|DYRK4_uc001qmy.1_Missense_Mutation_p.R411W|DYRK4_uc001qmz.1_Missense_Mutation_p.R125W|DYRK4_uc001qna.1_Missense_Mutation_p.R48W|DYRK4_uc010ser.1_Missense_Mutation_p.R48W	NM_003845	NP_003836	Q9NR20	DYRK4_HUMAN	dual-specificity tyrosine-(Y)-phosphorylation	411						Golgi apparatus	ATP binding|metal ion binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			lung(2)|skin(1)	3			Colorectal(7;0.103)			GCCACAGCCCAGGCCCCAGAC	0.542		NA											23	149					0	0	0	0
RERG	85004	broad.mit.edu	37	12	15262344	15262344	+	Silent	SNP	G	G	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr12:15262344G>A	uc001rcs.2	-	4	440	c.300C>T	c.(298-300)AAC>AAT	p.N100N	RERG_uc001rct.2_Silent_p.N100N|RERG_uc010shu.1_Silent_p.N81N	NM_032918	NP_116307	Q96A58	RERG_HUMAN	RAS-like, estrogen-regulated, growth inhibitor	100					negative regulation of cell growth|negative regulation of cell proliferation|response to hormone stimulus|small GTPase mediated signal transduction	cytosol|membrane|nucleus	estrogen receptor binding|GDP binding|GTP binding|GTPase activity			lung(1)	1						CATCTAGGATGTTCTTAAGTG	0.498		NA											91	414					0	0	0	0
SFRS2IP	9169	broad.mit.edu	37	12	46316327	46316327	+	Silent	SNP	T	T	C			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr12:46316327T>C	uc001rox.2	-	14	4451	c.4164A>G	c.(4162-4164)AAA>AAG	p.K1388K	SFRS2IP_uc001row.2_Silent_p.K1073K	NM_004719	NP_004710	Q99590	SCAFB_HUMAN	splicing factor, arginine/serine-rich 2,	1388					spliceosome assembly	nucleus	protein binding|zinc ion binding				0	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.209)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.1)		TGATGGCCAATTTTACCTCTT	0.323		NA											20	96					0	0	0	0
DIP2B	57609	broad.mit.edu	37	12	51080428	51080428	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr12:51080428A>T	uc001rwv.2	+	12	1670	c.1514A>T	c.(1513-1515)CAC>CTC	p.H505L	DIP2B_uc009zlt.2_5'UTR	NM_173602	NP_775873	Q9P265	DIP2B_HUMAN	DIP2 disco-interacting protein 2 homolog B	505						nucleus	catalytic activity|transcription factor binding			ovary(4)|breast(1)|pancreas(1)	6						TGGCAGCCACACATCTCACCT	0.458		NA											4	24					0	0	0	0
NAV3	89795	broad.mit.edu	37	12	78452823	78452823	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr12:78452823G>A	uc001syp.2	+	12	2737	c.2564G>A	c.(2563-2565)CGA>CAA	p.R855Q	NAV3_uc001syo.2_Missense_Mutation_p.R855Q|NAV3_uc010sub.1_Missense_Mutation_p.R355Q	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	855						nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						AGTCTGAACCGAATACCAGAC	0.413		NA								HNSCC(70;0.22)			20	89					0	0	0	0
HNF1A	6927	broad.mit.edu	37	12	121431330	121431330	+	Silent	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr12:121431330C>T	uc001tzg.2	+	3	557	c.534C>T	c.(532-534)ACC>ACT	p.T178T	HNF1A_uc001tze.1_Silent_p.T178T|HNF1A_uc001tzf.2_Silent_p.T178T|HNF1A_uc010szn.1_Silent_p.T178T	NM_000545	NP_000536	P20823	HNF1A_HUMAN	hepatic nuclear factor-1-alpha	178					glucose homeostasis|glucose import|insulin secretion|positive regulation of transcription initiation from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|renal glucose absorption	cytoplasm|nucleus|protein complex	DNA binding|protein dimerization activity|protein heterodimerization activity|protein homodimerization activity|RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding			liver(92)|large_intestine(15)|endometrium(6)|breast(2)|lung(1)	116	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CAGAGTTCACCCATGCAGGGC	0.587		NA							Hepatic_Adenoma_Familial_Clustering_of				6	38					0	0	0	0
OASL	8638	broad.mit.edu	37	12	121461833	121461833	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr12:121461833T>C	uc001tzj.1	-	5	1013	c.1007A>G	c.(1006-1008)TAT>TGT	p.Y336C	OASL_uc001tzk.1_Silent_p.L255L	NM_003733	NP_003724	Q15646	OASL_HUMAN	2'-5'-oligoadenylate synthetase-like isoform a	336					interferon-gamma-mediated signaling pathway|type I interferon-mediated signaling pathway	cytoplasm|nucleolus	ATP binding|DNA binding|double-stranded RNA binding|thyroid hormone receptor binding|transferase activity			skin(1)	1	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					CCTGTTGTCATAGCAACAGTC	0.557		NA											5	102					0	0	0	0
MIPEP	4285	broad.mit.edu	37	13	24460635	24460635	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr13:24460635C>T	uc001uox.3	-	2	300	c.200G>A	c.(199-201)GGA>GAA	p.G67E	PCOTH_uc001uoy.2_5'Flank|PCOTH_uc009zzx.2_5'Flank	NM_005932	NP_005923	Q99797	MIPEP_HUMAN	mitochondrial intermediate peptidase precursor	67					protein processing involved in protein targeting to mitochondrion|proteolysis	mitochondrial matrix	metal ion binding|metalloendopeptidase activity			central_nervous_system(1)	1		all_cancers(29;1.83e-22)|all_epithelial(30;8.75e-19)|all_lung(29;9.17e-18)|Lung SC(185;0.0225)|Breast(139;0.14)		all cancers(112;0.00389)|Epithelial(112;0.0266)|OV - Ovarian serous cystadenocarcinoma(117;0.0717)|Lung(94;0.207)|GBM - Glioblastoma multiforme(144;0.232)		CTCAGGAACTCCAAAAAGACC	0.373		NA											25	120					0	0	0	0
ATP12A	479	broad.mit.edu	37	13	25276139	25276139	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr13:25276139T>C	uc001upp.2	+	14	2135	c.1948T>C	c.(1948-1950)TCA>CCA	p.S650P	ATP12A_uc010aaa.2_Missense_Mutation_p.S656P	NM_001676	NP_001667	P54707	AT12A_HUMAN	hydrogen/potassium-exchanging ATPase 12A	650	Cytoplasmic (Potential).				ATP biosynthetic process	hydrogen:potassium-exchanging ATPase complex	ATP binding|hydrogen:potassium-exchanging ATPase activity|metal ion binding			ovary(2)|central_nervous_system(2)|large_intestine(1)|breast(1)	6		Lung SC(185;0.0225)|Breast(139;0.077)		all cancers(112;0.0307)|Epithelial(112;0.086)|OV - Ovarian serous cystadenocarcinoma(117;0.228)	Esomeprazole(DB00736)|Pantoprazole(DB00213)	GGGGATCATTTCAGCCAACAG	0.458		NA											22	131					0	0	0	0
FRY	10129	broad.mit.edu	37	13	32841345	32841345	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr13:32841345C>T	uc001utx.2	+	55	8481	c.7985C>T	c.(7984-7986)TCG>TTG	p.S2662L	FRY_uc010tdw.1_RNA|FRY_uc001uty.2_Missense_Mutation_p.S217L|FRY_uc001utz.2_Missense_Mutation_p.S187L|FRY_uc010tdx.1_Missense_Mutation_p.S32L	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	2662					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		CCCCCTCCCTCGCCCTTCTTC	0.537		NA											47	230					0	0	0	0
LRCH1	23143	broad.mit.edu	37	13	47260079	47260079	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr13:47260079G>C	uc001vbj.2	+	5	961	c.725G>C	c.(724-726)TGC>TCC	p.C242S	LRCH1_uc010acp.2_Missense_Mutation_p.C242S|LRCH1_uc001vbk.2_Missense_Mutation_p.C242S|LRCH1_uc001vbl.3_Missense_Mutation_p.C242S	NM_015116	NP_055931	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH)	242	LRR 7.									ovary(1)|central_nervous_system(1)	2		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		GACTTTTCCTGCAACAAAGTG	0.323		NA											7	55					0	0	0	0
WDFY2	115825	broad.mit.edu	37	13	52313218	52313218	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr13:52313218A>T	uc001vfp.2	+	7	972	c.632A>T	c.(631-633)CAG>CTG	p.Q211L	WDFY2_uc010ads.1_Missense_Mutation_p.Q211L|WDFY2_uc010adt.1_RNA	NM_052950	NP_443182	Q96P53	WDFY2_HUMAN	WD repeat and FYVE domain containing 2	211	WD 5.						metal ion binding				0		Breast(56;0.000208)|Lung NSC(96;0.000517)|Prostate(109;0.0041)|Hepatocellular(98;0.0652)|Myeloproliferative disorder(33;0.164)|all_neural(104;0.191)		GBM - Glioblastoma multiforme(99;9e-08)		GACCCAGTCCAGCGGGTGTTG	0.512		NA											43	215					0	0	0	0
SLITRK5	26050	broad.mit.edu	37	13	88329623	88329623	+	Silent	SNP	G	G	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr13:88329623G>A	uc001vln.2	+	2	2199	c.1980G>A	c.(1978-1980)TCG>TCA	p.S660S	SLITRK5_uc010tic.1_Silent_p.S419S	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	660	Extracellular (Potential).					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					GGGCGTCGTCGGTGCCCTTGT	0.642		NA											7	51					0	0	0	0
GPC6	10082	broad.mit.edu	37	13	94482798	94482798	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr13:94482798G>T	uc001vlt.2	+	3	1343	c.711G>T	c.(709-711)AAG>AAT	p.K237N	GPC6_uc010tig.1_Missense_Mutation_p.K237N|GPC6_uc001vlu.1_Missense_Mutation_p.K167N	NM_005708	NP_005699	Q9Y625	GPC6_HUMAN	glypican 6 precursor	237						anchored to membrane|extracellular space|integral to plasma membrane|proteinaceous extracellular matrix	heparan sulfate proteoglycan binding				0	all_neural(89;0.0684)|Medulloblastoma(90;0.163)	all_cancers(2;5.48e-07)|all_epithelial(2;5.69e-08)|all_lung(2;2.19e-05)|Lung NSC(4;6.09e-05)|Breast(118;0.0395)|Renal(2;0.0568)|Hepatocellular(115;0.217)				GAGTTTCCAAGGTAATTGAAA	0.398		NA											9	61					1.13e-05	1.23e-05	1	0
SLC10A2	6555	broad.mit.edu	37	13	103710731	103710731	+	Missense_Mutation	SNP	C	C	T	rs150843319	by1000genomes	TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr13:103710731C>T	uc001vpy.3	-	2	976	c.379G>A	c.(379-381)GTC>ATC	p.V127I		NM_000452	NP_000443	Q12908	NTCP2_HUMAN	solute carrier family 10 (sodium/bile acid	127	Helical; (Potential).				bile acid metabolic process|organic anion transport	integral to plasma membrane	bile acid:sodium symporter activity			ovary(3)|skin(1)	4	all_neural(89;0.0662)|Medulloblastoma(90;0.163)|Lung SC(71;0.211)					GTCATGCTGACGCTGAAAGGC	0.408		NA											14	84					0	0	0	0
REM2	161253	broad.mit.edu	37	14	23355326	23355326	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr14:23355326A>G	uc001whf.1	+	4	678	c.613A>G	c.(613-615)AAA>GAA	p.K205E	REM2_uc010tnd.1_Missense_Mutation_p.Q172R	NM_173527	NP_775798	Q8IYK8	REM2_HUMAN	rad and gem related GTP binding protein 2	205					regulation of transcription, DNA-dependent|small GTPase mediated signal transduction	intracellular|plasma membrane	ATP binding|GTP binding|transcription factor binding			large_intestine(1)|central_nervous_system(1)	2	all_cancers(95;4.69e-05)			GBM - Glioblastoma multiforme(265;0.012)		GAGTTTCTCCAAAGTTCCAGA	0.627		NA											13	73					0	0	0	0
JUB	84962	broad.mit.edu	37	14	23444270	23444270	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr14:23444270C>T	uc001whz.2	-	5	1659	c.1283G>A	c.(1282-1284)CGA>CAA	p.R428Q	JUB_uc001why.2_Missense_Mutation_p.R11Q	NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	428	LIM zinc-binding 2.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		AACAATGCATCGGAAACAGCC	0.532		NA											5	106					0	0	0	0
CDKL1	8814	broad.mit.edu	37	14	50863888	50863888	+	Silent	SNP	A	A	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr14:50863888A>T	uc010anu.1	-	4	402	c.402T>A	c.(400-402)GCT>GCA	p.A134A	CDKL1_uc001wxz.2_5'Flank	NM_004196	NP_004187	Q00532	CDKL1_HUMAN	cyclin-dependent kinase-like 1	Error:Variant_position_missing_in_Q00532_after_alignment						cytoplasm|nucleus	ATP binding|cyclin-dependent protein kinase activity			ovary(1)|stomach(1)	2	all_epithelial(31;0.000746)|Breast(41;0.0102)					CTGCGCTAGGAGCCCCTCCTG	0.602		NA											5	45					0	0	0	0
RDH12	145226	broad.mit.edu	37	14	68191267	68191267	+	Missense_Mutation	SNP	C	C	T	rs28940314		TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr14:68191267C>T	uc001xjz.3	+	4	470	c.146C>T	c.(145-147)ACG>ATG	p.T49M		NM_152443	NP_689656	Q96NR8	RDH12_HUMAN	retinol dehydrogenase 12	49	NADP (By similarity).				photoreceptor cell maintenance|response to stimulus|retinol metabolic process	intracellular	binding|retinol dehydrogenase activity			ovary(1)	1				all cancers(60;0.000704)|OV - Ovarian serous cystadenocarcinoma(108;0.00161)|BRCA - Breast invasive adenocarcinoma(234;0.00953)	Vitamin A(DB00162)	GGCGCCAACACGGGCATTGGC	0.557		NA											19	72					0	0	0	0
C14orf118	55668	broad.mit.edu	37	14	76642983	76642983	+	Silent	SNP	T	T	G			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr14:76642983T>G	uc001xsh.2	+	6	1088	c.1002T>G	c.(1000-1002)ACT>ACG	p.T334T	C14orf118_uc001xsi.2_Silent_p.T334T|C14orf118_uc001xsj.1_3'UTR|C14orf118_uc001xsk.1_3'UTR|C14orf118_uc001xsl.2_RNA	NM_017926	NP_060396	Q9NWQ4	CN118_HUMAN	hypothetical protein LOC55668 isoform 1	334										ovary(2)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(234;0.0172)		GCATAAACACTTTGGGGACTG	0.413		NA											27	152					0	0	0	0
PPP4R4	57718	broad.mit.edu	37	14	94711996	94711996	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr14:94711996C>T	uc001ycs.1	+	13	1571	c.1417C>T	c.(1417-1419)CAA>TAA	p.Q473*		NM_058237	NP_478144	Q6NUP7	PP4R4_HUMAN	HEAT-like repeat-containing protein isoform 1	473						cytoplasm|protein serine/threonine phosphatase complex	protein binding			skin(3)|upper_aerodigestive_tract(1)	4						AAGCAGTGTTCAAGAAAATAA	0.249		NA											25	148					0	0	0	0
C15orf2	23742	broad.mit.edu	37	15	24923846	24923846	+	Silent	SNP	T	T	C			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr15:24923846T>C	uc001ywo.2	+	1	3306	c.2832T>C	c.(2830-2832)GGT>GGC	p.G944G		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	944					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		TTCCACCAGGTTTTGCAGAGT	0.483		NA											24	108					0	0	0	0
MTMR15	22909	broad.mit.edu	37	15	31229329	31229329	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr15:31229329A>G	uc001zff.2	+	14	3215	c.2924A>G	c.(2923-2925)GAA>GGA	p.E975G	MTMR15_uc001zfe.2_Missense_Mutation_p.E580G	NM_014967	NP_055782	Q9Y2M0	FAN1_HUMAN	myotubularin related protein 15 isoform a	975	VRR-NUC.			E->A: Loss of nuclease activity; when associated with A-864; A-960 and A-977.	double-strand break repair via homologous recombination|nucleotide-excision repair, DNA incision	nucleus	5'-3' exonuclease activity|5'-flap endonuclease activity|DNA binding|magnesium ion binding|phosphodiesterase I activity|ubiquitin binding				0		all_lung(180;2.23e-09)		all cancers(64;4.72e-15)|Epithelial(43;5.4e-11)|GBM - Glioblastoma multiforme(186;0.000136)|BRCA - Breast invasive adenocarcinoma(123;0.00402)|Lung(196;0.168)		CAGCTGGTGGAAGTTAAAGGC	0.398		NA						Direct_reversal_of_damage|Editing_and_processing_nucleases					14	134					0	0	0	0
RYR3	6263	broad.mit.edu	37	15	34040349	34040349	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr15:34040349C>G	uc001zhi.2	+	54	8094	c.8024C>G	c.(8023-8025)TCC>TGC	p.S2675C	RYR3_uc010bar.2_Missense_Mutation_p.S2675C	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	2675	3.|Cytoplasmic (By similarity).|4 X approximate repeats.				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		GCGCGAGAGTCCCTGAAAACC	0.527		NA											16	99					0	0	0	0
TYRO3	7301	broad.mit.edu	37	15	41870164	41870164	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr15:41870164A>T	uc001zof.1	+	19	2587	c.2363A>T	c.(2362-2364)AAC>ATC	p.N788I		NM_006293	NP_006284	Q06418	TYRO3_HUMAN	TYRO3 protein tyrosine kinase precursor	788	Protein kinase.|Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|receptor signaling protein tyrosine kinase activity|transmembrane receptor protein tyrosine kinase activity			ovary(3)|lung(2)|central_nervous_system(1)	6		all_cancers(109;7.33e-15)|all_epithelial(112;2.8e-12)|Lung NSC(122;3.48e-08)|all_lung(180;1.71e-07)|Melanoma(134;0.0262)		OV - Ovarian serous cystadenocarcinoma(18;3.31e-18)|GBM - Glioblastoma multiforme(113;9.31e-07)|BRCA - Breast invasive adenocarcinoma(123;0.117)		GAACTGGAGAACATCTTGGGC	0.572		NA											9	102					0	0	0	0
DMXL2	23312	broad.mit.edu	37	15	51806663	51806663	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr15:51806663C>G	uc002abf.2	-	15	2845	c.2620G>C	c.(2620-2622)GAA>CAA	p.E874Q	DMXL2_uc010ufy.1_Missense_Mutation_p.E874Q|DMXL2_uc010bfa.2_Missense_Mutation_p.E874Q	NM_015263	NP_056078	Q8TDJ6	DMXL2_HUMAN	Dmx-like 2	874						cell junction|synaptic vesicle membrane	Rab GTPase binding			ovary(6)|skin(3)	9				all cancers(107;0.00494)		AAAAATATTTCTGTTTCCTTT	0.318		NA											32	213					0	0	0	0
ANPEP	290	broad.mit.edu	37	15	90328694	90328694	+	Silent	SNP	G	G	A	rs145116014		TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr15:90328694G>A	uc002bop.3	-	21	3082	c.2790C>T	c.(2788-2790)TTC>TTT	p.F930F		NM_001150	NP_001141	P15144	AMPN_HUMAN	membrane alanine aminopeptidase precursor	930	Extracellular.|Metalloprotease.				angiogenesis|cell differentiation|interspecies interaction between organisms	cytosol|ER-Golgi intermediate compartment|integral to plasma membrane	aminopeptidase activity|metallopeptidase activity|receptor activity|zinc ion binding			ovary(3)|skin(1)	4	Lung NSC(78;0.0221)|all_lung(78;0.0448)		BRCA - Breast invasive adenocarcinoma(143;0.0146)|KIRC - Kidney renal clear cell carcinoma(17;0.0286)|Kidney(142;0.0514)|STAD - Stomach adenocarcinoma(125;0.169)		Ezetimibe(DB00973)	TGCCTGAGCCGAAGCCTGTTT	0.562		NA											14	212					0	0	0	0
ZSCAN10	84891	broad.mit.edu	37	16	3140386	3140386	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr16:3140386G>A	uc002ctv.1	-	5	972	c.884C>T	c.(883-885)GCG>GTG	p.A295V	ZSCAN10_uc002cty.1_5'UTR|ZSCAN10_uc002ctw.1_Missense_Mutation_p.A213V|ZSCAN10_uc002ctx.1_Missense_Mutation_p.A223V	NM_032805	NP_116194	Q96SZ4	ZSC10_HUMAN	zinc finger and SCAN domain containing 10	295	C2H2-type 1.				negative regulation of transcription, DNA-dependent|viral reproduction	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)	1						CCCGCAGTCCGCGCAGATGAA	0.637		NA											7	129					0	0	0	0
MON1B	22879	broad.mit.edu	37	16	77229463	77229463	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr16:77229463G>C	uc002fez.2	+	5	1657	c.1327G>C	c.(1327-1329)GAG>CAG	p.E443Q	MON1B_uc010vnf.1_Missense_Mutation_p.E334Q|MON1B_uc010vng.1_Missense_Mutation_p.E297Q|MON1B_uc002ffa.2_Missense_Mutation_p.E323Q	NM_014940	NP_055755	Q7L1V2	MON1B_HUMAN	MON1 homolog B	443							protein binding				0						CAGCAGAGAGGAGGAGCGGCA	0.632		NA											5	24					0	0	0	0
SLC38A8	146167	broad.mit.edu	37	16	84050761	84050761	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr16:84050761C>T	uc002fhg.1	-	7	937	c.937G>A	c.(937-939)GTG>ATG	p.V313M		NM_001080442	NP_001073911	A6NNN8	S38A8_HUMAN	solute carrier family 38, member 8	313	Helical; (Potential).				amino acid transport|sodium ion transport	integral to membrane					0						AGGAAGAGCACGATGGGGTAG	0.522		NA											10	56					0	0	0	0
PRDM7	11105	broad.mit.edu	37	16	90133294	90133294	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr16:90133294C>T	uc010cje.2	-	4	346	c.326G>A	c.(325-327)AGA>AAA	p.R109K	PRDM7_uc010cjf.2_Intron|PRDM7_uc010cjh.1_RNA	NM_001098173	NP_001091643	Q9NQW5	PRDM7_HUMAN	PR domain containing 7 isoform 1	109						chromosome|nucleus	nucleic acid binding			ovary(1)	1		all_cancers(9;4.44e-13)|Lung NSC(15;1.56e-06)|all_lung(18;2.18e-06)|all_neural(9;0.00118)|all_hematologic(23;0.0194)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		CTGTTCTCCTCTGAAGGCCAT	0.373		NA											46	281					0	0	0	0
RPH3AL	9501	broad.mit.edu	37	17	169309	169309	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr17:169309G>A	uc002frd.1	-	3	297	c.253C>T	c.(253-255)CGG>TGG	p.R85W	RPH3AL_uc010vpy.1_Missense_Mutation_p.R85W|RPH3AL_uc002fre.1_Missense_Mutation_p.R85W|RPH3AL_uc002frf.1_Missense_Mutation_p.R85W|RPH3AL_uc010cjl.1_Missense_Mutation_p.R85W	NM_006987	NP_008918	Q9UNE2	RPH3L_HUMAN	rabphilin 3A-like (without C2 domains)	85	RabBD.			R -> Q (in Ref. 4; AAH05153).	exocytosis|intracellular protein transport	transport vesicle membrane	cytoskeletal protein binding|Rab GTPase binding|zinc ion binding			skin(1)	1				UCEC - Uterine corpus endometrioid carcinoma (25;0.023)|all cancers(1;4.96e-06)|Epithelial(1;2.86e-05)|BRCA - Breast invasive adenocarcinoma(1;0.00453)|OV - Ovarian serous cystadenocarcinoma(1;0.0716)|LUAD - Lung adenocarcinoma(1115;0.102)|COAD - Colon adenocarcinoma(4;0.107)		ATCACATTCCGCCTCATGGTC	0.632		NA											5	40					0	0	0	0
TOM1L2	146691	broad.mit.edu	37	17	17788024	17788024	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr17:17788024T>A	uc002grz.3	-	5	582	c.425A>T	c.(424-426)GAG>GTG	p.E142V	TOM1L2_uc002gry.3_Missense_Mutation_p.E92V|TOM1L2_uc010vwy.1_Missense_Mutation_p.E142V|TOM1L2_uc010cpr.2_Intron|TOM1L2_uc010vwz.1_Intron|TOM1L2_uc010vxa.1_Intron|TOM1L2_uc010vxb.1_Missense_Mutation_p.E92V	NM_001082968	NP_001076437	Q6ZVM7	TM1L2_HUMAN	target of myb1-like 2 isoform 3	142	VHS.				intracellular protein transport	intracellular					0	all_neural(463;0.228)					CTTCAGCTCCTCATATATGTG	0.517		NA											23	207					0	0	0	0
ABHD15	116236	broad.mit.edu	37	17	27893561	27893561	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr17:27893561C>G	uc002hed.1	-	1	488	c.424G>C	c.(424-426)GGA>CGA	p.G142R	TP53I13_uc002hee.2_5'Flank	NM_198147	NP_937790	Q6UXT9	ABH15_HUMAN	abhydrolase domain containing 15 precursor	142						extracellular region	carboxylesterase activity				0						ACACAAGGTCCTACCACCCAG	0.687		NA											3	28					0	0	0	0
WIPF2	147179	broad.mit.edu	37	17	38421105	38421105	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr17:38421105C>T	uc002hug.1	+	5	917	c.677C>T	c.(676-678)GCT>GTT	p.A226V	WIPF2_uc002huh.1_Missense_Mutation_p.A76V|WIPF2_uc010cww.1_Missense_Mutation_p.A76V|WIPF2_uc002hui.1_Missense_Mutation_p.A226V|WIPF2_uc010cwx.1_Intron|WIPF2_uc010cwy.1_Missense_Mutation_p.A226V	NM_133264	NP_573571	Q8TF74	WIPF2_HUMAN	WIRE protein	226						cytoplasm|cytoskeleton	actin binding			upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	3						GGACCTCCTGCTCCACCCCCA	0.607		NA								HNSCC(43;0.11)			29	213					0	0	0	0
KIAA1267	284058	broad.mit.edu	37	17	44109631	44109631	+	Nonsense_Mutation	SNP	G	G	A	rs147378906		TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr17:44109631G>A	uc002ikb.2	-	13	2957	c.2872C>T	c.(2872-2874)CAG>TAG	p.Q958*	KIAA1267_uc002ikc.2_Nonsense_Mutation_p.Q958*|KIAA1267_uc002ikd.2_Nonsense_Mutation_p.Q958*|KIAA1267_uc010dav.2_Nonsense_Mutation_p.Q957*|KIAA1267_uc010wkb.1_Nonsense_Mutation_p.Q289*|KIAA1267_uc010wkc.1_Nonsense_Mutation_p.Q226*	NM_015443	NP_056258	Q7Z3B3	K1267_HUMAN	hypothetical protein LOC284058	958						MLL1 complex	protein binding			skin(2)	2		Melanoma(429;0.211)				CTGCCCAGCTGGGGGGTTGTC	0.577		NA											11	76					0	0	0	0
ANKFN1	162282	broad.mit.edu	37	17	54230890	54230890	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr17:54230890G>A	uc002iun.1	+	1	55	c.20G>A	c.(19-21)AGG>AAG	p.R7K		NM_153228	NP_694960	Q8N957	ANKF1_HUMAN	ankyrin-repeat and fibronectin type III domain	7										large_intestine(1)|ovary(1)	2						TCTCTAACCAGGGTAGGAAAA	0.488		NA											11	112					0	0	0	0
TRIM37	4591	broad.mit.edu	37	17	57181722	57181722	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr17:57181722T>C	uc002iwy.3	-	2	499	c.55A>G	c.(55-57)ATG>GTG	p.M19V	TRIM37_uc002iwz.3_Missense_Mutation_p.M19V|TRIM37_uc002ixa.3_5'UTR|TRIM37_uc010woc.1_Intron|uc002ixb.2_5'Flank	NM_001005207	NP_001005207	O94972	TRI37_HUMAN	tripartite motif-containing 37 protein	19	RING-type; degenerate.					perinuclear region of cytoplasm|peroxisome	ligase activity|protein binding|zinc ion binding			lung(2)|pancreas(2)|ovary(1)|skin(1)|breast(1)	7	Medulloblastoma(34;0.0922)|all_neural(34;0.101)					AATTTCTCCATACAAATGAAA	0.408		NA							Mulibrey_Nanism				15	92					0	0	0	0
MED13	9969	broad.mit.edu	37	17	60050211	60050211	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr17:60050211G>A	uc002izo.2	-	17	3921	c.3844C>T	c.(3844-3846)CTC>TTC	p.L1282F		NM_005121	NP_005112	Q9UHV7	MED13_HUMAN	mediator complex subunit 13	1282	LXXLL motif 2.				androgen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			large_intestine(1)|ovary(1)	2						AGAGAGAGGAGCATTCGAAGT	0.373		NA											60	249					0	0	0	0
TLK2	11011	broad.mit.edu	37	17	60678092	60678092	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr17:60678092A>G	uc010ddp.2	+	19	1965	c.1697A>G	c.(1696-1698)GAG>GGG	p.E566G	TLK2_uc002izx.3_Missense_Mutation_p.E392G|TLK2_uc002izz.3_Missense_Mutation_p.E544G|TLK2_uc002jaa.3_Missense_Mutation_p.E512G|TLK2_uc010wpd.1_Missense_Mutation_p.E512G	NM_006852	NP_006843	Q86UE8	TLK2_HUMAN	tousled-like kinase 2 isoform A	566	Protein kinase.				cell cycle|chromatin modification|intracellular signal transduction|regulation of chromatin assembly or disassembly|response to DNA damage stimulus	nucleus	ATP binding|protein binding|protein serine/threonine kinase activity			stomach(1)|kidney(1)	2						TCGGAGAAAGAGGCCCGGTCC	0.368		NA											19	97					0	0	0	0
ABCA10	10349	broad.mit.edu	37	17	67197795	67197795	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr17:67197795C>T	uc010dfa.1	-	11	1900	c.1021G>A	c.(1021-1023)GGG>AGG	p.G341R	ABCA10_uc010wqt.1_RNA|ABCA10_uc010dfb.1_5'UTR|ABCA10_uc010dfc.1_Intron	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	341					transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					GGAGAATCCCCATGGCCATCT	0.313		NA											6	75					0	0	0	0
RFNG	5986	broad.mit.edu	37	17	80006664	80006664	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr17:80006664G>A	uc002kdj.2	-	8	942	c.934C>T	c.(934-936)CTT>TTT	p.L312F	RFNG_uc002kdh.2_Missense_Mutation_p.L97F	NM_002917	NP_002908	Q9Y644	RFNG_HUMAN	radical fringe	312	Lumenal (Potential).				cell differentiation|nervous system development|organ morphogenesis|pattern specification process	extracellular region|integral to Golgi membrane	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity			central_nervous_system(1)	1	all_neural(118;0.0878)|Ovarian(332;0.227)|all_lung(278;0.246)		BRCA - Breast invasive adenocarcinoma(99;0.0114)|OV - Ovarian serous cystadenocarcinoma(97;0.0211)			GGGTACAGAAGACAATGGATA	0.408		NA											7	81					0	0	0	0
CDH19	28513	broad.mit.edu	37	18	64239419	64239419	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr18:64239419C>T	uc002lkc.1	-	2	161	c.23G>A	c.(22-24)CGT>CAT	p.R8H	CDH19_uc010dql.1_RNA|CDH19_uc010xey.1_Missense_Mutation_p.R8H|CDH19_uc002lkd.2_Missense_Mutation_p.R8H	NM_021153	NP_066976	Q9H159	CAD19_HUMAN	cadherin 19, type 2 preproprotein	8					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2		Esophageal squamous(42;0.0132)				CAACATAAAACGCAGCAGTAA	0.398		NA											4	99					0	0	0	0
ZNF791	163049	broad.mit.edu	37	19	12734621	12734621	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr19:12734621C>G	uc002mua.2	+	2	273	c.111C>G	c.(109-111)TTC>TTG	p.F37L	ZNF791_uc010xml.1_Missense_Mutation_p.F5L|ZNF791_uc010dyu.1_5'UTR|ZNF791_uc010xmm.1_Intron	NM_153358	NP_699189	Q3KP31	ZN791_HUMAN	zinc finger protein 791	37	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)	2						AGGAAACATTCAAGAACCTGG	0.323		NA											16	108					0	0	0	0
CPAMD8	27151	broad.mit.edu	37	19	17038893	17038893	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr19:17038893T>C	uc002nfb.2	-	25	3469	c.3437A>G	c.(3436-3438)TAC>TGC	p.Y1146C		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	1099						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						GGCCTCGCTGTAGCTCTCGTC	0.637		NA											4	91					0	0	0	0
ZNF208	7757	broad.mit.edu	37	19	22155688	22155688	+	Silent	SNP	A	A	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr19:22155688A>T	uc002nqp.2	-	5	1997	c.1848T>A	c.(1846-1848)ACT>ACA	p.T616T	ZNF208_uc002nqo.1_Intron	NM_007153	NP_009084			zinc finger protein 208											ovary(5)|skin(2)	7		all_lung(12;0.0961)|Lung NSC(12;0.103)				GTTTCTCTCCAGTATGAATTC	0.373		NA											12	111					0	0	0	0
ZNF181	339318	broad.mit.edu	37	19	35231761	35231761	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr19:35231761A>G	uc002nvu.3	+	4	938	c.475A>G	c.(475-477)ATA>GTA	p.I159V	ZNF181_uc010xsa.1_Missense_Mutation_p.I158V|ZNF181_uc010xsb.1_Missense_Mutation_p.I158V|ZNF181_uc010xsc.1_Missense_Mutation_p.I94V	NM_001029997	NP_001025168	Q2M3W8	ZN181_HUMAN	zinc finger protein 181 isoform 1	159					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1	all_lung(56;1.13e-07)|Lung NSC(56;1.81e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.138)			CAAATACAATATATTTAGAAG	0.373		NA											23	104					0	0	0	0
SERTAD1	29950	broad.mit.edu	37	19	40928872	40928872	+	Silent	SNP	G	G	C			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr19:40928872G>C	uc002ont.3	-	2	741	c.582C>G	c.(580-582)CTC>CTG	p.L194L		NM_013376	NP_037508	Q9UHV2	SRTD1_HUMAN	SERTA domain containing 1	194					positive regulation of cell proliferation|regulation of cyclin-dependent protein kinase activity|regulation of transcription, DNA-dependent|transcription, DNA-dependent						0			Lung(22;6.24e-05)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GGCCTGGTTTGAGGCCCTCAG	0.582		NA											6	26					0	0	0	0
SFRS16	11129	broad.mit.edu	37	19	45561107	45561107	+	Silent	SNP	G	G	A	rs143800882	byFrequency	TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr19:45561107G>A	uc002pak.2	+	7	662	c.564G>A	c.(562-564)GCG>GCA	p.A188A	SFRS16_uc002pal.2_RNA|SFRS16_uc010xxh.1_Silent_p.A126A|SFRS16_uc002pam.2_Silent_p.A188A|SFRS16_uc002pan.1_RNA	NM_007056	NP_008987	Q8N2M8	CLASR_HUMAN	splicing factor, arginine/serine-rich 16	188					mRNA processing|RNA splicing	nucleus					0		Ovarian(192;0.0728)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0102)		AGGAGTCAGCGGCCGAGGAGG	0.612		NA											12	95					0	0	0	0
OPA3	80207	broad.mit.edu	37	19	46032622	46032622	+	Silent	SNP	G	G	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr19:46032622G>A	uc002pcj.3	-	2	335	c.235C>T	c.(235-237)CTG>TTG	p.L79L		NM_001017989	NP_001017989	Q9H6K4	OPA3_HUMAN	OPA3 protein isoform a	79					response to stimulus|visual perception	mitochondrion					0		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.00778)|GBM - Glioblastoma multiforme(486;0.0976)|Epithelial(262;0.242)		TCCGCGCCCAGCTCGGCGGCT	0.627		NA											10	82					0	0	0	0
IGFL2	147920	broad.mit.edu	37	19	46664118	46664118	+	Silent	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr19:46664118C>T	uc010xxv.1	+	3	357	c.321C>T	c.(319-321)CCC>CCT	p.P107P	IGFL2_uc002peb.2_Silent_p.P118P	NM_001135113	NP_001128585	Q6UWQ7	IGFL2_HUMAN	IGF-like family member 2 isoform b	107						extracellular region	protein binding				0		Ovarian(192;0.0908)|all_neural(266;0.113)		OV - Ovarian serous cystadenocarcinoma(262;0.00493)|GBM - Glioblastoma multiforme(486;0.031)|Epithelial(262;0.247)		ACTCATCTCCCATCTCCAGTA	0.532		NA											5	129					0	0	0	0
DHX34	9704	broad.mit.edu	37	19	47865870	47865870	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr19:47865870G>A	uc010xyn.1	+	6	1854	c.1513G>A	c.(1513-1515)GCC>ACC	p.A505T	DHX34_uc010elc.1_Missense_Mutation_p.A420T	NM_014681	NP_055496	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	505	Helicase C-terminal.					intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		CCGCCTCTATGCCGAATCGGA	0.657		NA											9	51					0	0	0	0
SLC4A1AP	22950	broad.mit.edu	37	2	27890212	27890212	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr2:27890212A>G	uc002rlk.3	+	3	1381	c.1099A>G	c.(1099-1101)ATA>GTA	p.I367V		NM_018158	NP_060628	Q9BWU0	NADAP_HUMAN	solute carrier family 4 (anion exchanger),	367						cytoplasm|nucleus	double-stranded RNA binding|protein binding				0	Acute lymphoblastic leukemia(172;0.155)					GGCCTTTTATATAAAGGATCC	0.418		NA											26	123					0	0	0	0
SLC8A1	6546	broad.mit.edu	37	2	40656013	40656013	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr2:40656013C>T	uc002rrx.2	-	1	1432	c.1408G>A	c.(1408-1410)GAT>AAT	p.D470N	SLC8A1_uc002rry.2_Missense_Mutation_p.D470N|SLC8A1_uc002rrz.2_Missense_Mutation_p.D470N|SLC8A1_uc002rsa.2_Missense_Mutation_p.D470N|SLC8A1_uc002rsd.3_Missense_Mutation_p.D470N|SLC8A1_uc002rsb.1_Missense_Mutation_p.D470N|SLC8A1_uc010fan.1_Missense_Mutation_p.D470N|SLC8A1_uc002rsc.1_Missense_Mutation_p.D470N	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	470	Calx-beta 1.|Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TTCTGGGTATCACCAGGCTTA	0.408		NA											12	106					0	0	0	0
TUBA3D	113457	broad.mit.edu	37	2	132240222	132240222	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr2:132240222C>T	uc002tsu.3	+	5	1261	c.1154C>T	c.(1153-1155)GCG>GTG	p.A385V		NM_080386	NP_525125	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	385					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(221;0.13)		ACGGCCATTGCGGAGGCCTGG	0.632		NA											18	116					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	141027862	141027862	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr2:141027862T>C	uc002tvj.1	-	86	14168	c.13196A>G	c.(13195-13197)TAC>TGC	p.Y4399C		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	4399	Extracellular (Potential).|EGF-like 14.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GCCACCATTGTAACAGTAGCC	0.403		NA								TSP Lung(27;0.18)			12	132					0	0	0	0
LRP1B	53353	broad.mit.edu	37	2	141571360	141571360	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr2:141571360T>A	uc002tvj.1	-	32	6197	c.5225A>T	c.(5224-5226)TAT>TTT	p.Y1742F		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1742	Extracellular (Potential).|LDL-receptor class B 16.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GTTTTCCACATAGTCTATCGA	0.348		NA								TSP Lung(27;0.18)			13	109					0	0	0	0
ZC3H15	55854	broad.mit.edu	37	2	187364950	187364950	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr2:187364950C>G	uc002upo.2	+	3	444	c.219C>G	c.(217-219)GAC>GAG	p.D73E		NM_018471	NP_060941	Q8WU90	ZC3HF_HUMAN	erythropoietin 4 immediate early response	73	Potential.					cytoplasm|nucleolus|plasma membrane	nucleic acid binding|zinc ion binding			skin(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0148)|Epithelial(96;0.0922)|all cancers(119;0.233)			AGAAGGATGACAAGAAGAAAG	0.308		NA											6	51					0	0	0	0
CASP8	841	broad.mit.edu	37	2	202149860	202149860	+	Nonsense_Mutation	SNP	C	C	G			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr2:202149860C>G	uc002uxr.1	+	9	1333	c.1124C>G	c.(1123-1125)TCA>TGA	p.S375*	CASP8_uc002uxp.1_Nonsense_Mutation_p.S392*|CASP8_uc002uxq.1_Nonsense_Mutation_p.S360*|CASP8_uc002uxt.1_Nonsense_Mutation_p.S434*|CASP8_uc002uxu.1_RNA|CASP8_uc002uxw.1_Nonsense_Mutation_p.S360*|CASP8_uc002uxy.1_Intron|CASP8_uc002uxx.1_Intron|CASP8_uc010ftf.2_Nonsense_Mutation_p.S291*	NM_033355	NP_203519	Q14790	CASP8_HUMAN	caspase 8 isoform B precursor	375					activation of caspase activity|activation of pro-apoptotic gene products|cellular component disassembly involved in apoptosis|cellular response to mechanical stimulus|induction of apoptosis by extracellular signals|induction of apoptosis by intracellular signals|positive regulation of I-kappaB kinase/NF-kappaB cascade|proteolysis involved in cellular protein catabolic process|response to tumor necrosis factor	centrosome|cytosol|mitochondrial outer membrane	cysteine-type endopeptidase activity|protein binding|protein binding			upper_aerodigestive_tract(2)|ovary(1)|breast(1)|skin(1)	5						GAGACTGATTCAGAGGAGCAA	0.448		NA								HNSCC(4;0.00038)			25	112					0	0	0	0
C2orf24	27013	broad.mit.edu	37	2	220037648	220037648	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr2:220037648C>A	uc002vju.3	-	8	1045	c.893G>T	c.(892-894)TGC>TTC	p.C298F	NHEJ1_uc002vjq.3_5'Flank|SLC23A3_uc010zkr.1_5'Flank|SLC23A3_uc010zks.1_5'Flank|SLC23A3_uc010fwb.2_5'Flank|C2orf24_uc002vjv.2_Missense_Mutation_p.C298F	NM_015680	NP_056495	Q9BV87	CNPD1_HUMAN	hypothetical protein LOC27013	298					regulation of cyclin-dependent protein kinase activity	integral to membrane	protein kinase binding				0		Renal(207;0.0915)		Epithelial(149;8.92e-07)|all cancers(144;0.000151)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		GCCTTCCAGGCAGCTGGAGAC	0.647		NA											17	127					2.39e-15	2.78e-15	1	0
RBL1	5933	broad.mit.edu	37	20	35684633	35684633	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr20:35684633T>A	uc002xgi.2	-	10	1358	c.1279A>T	c.(1279-1281)ATT>TTT	p.I427F	RBL1_uc010zvt.1_RNA|RBL1_uc002xgj.1_Missense_Mutation_p.I427F|RBL1_uc010gfv.1_RNA	NM_002895	NP_002886	P28749	RBL1_HUMAN	retinoblastoma-like protein 1 isoform a	427	Domain A.|Pocket; binds T and E1A.				cell cycle|chromatin modification|interspecies interaction between organisms|regulation of cell cycle|regulation of lipid kinase activity|transcription, DNA-dependent		transcription factor binding			lung(5)|skin(3)|ovary(2)	10		Myeloproliferative disorder(115;0.00878)				ATTTTCATAATGTTTTCCACA	0.348		NA											13	51					0	0	0	0
SLC12A5	57468	broad.mit.edu	37	20	44676687	44676687	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr20:44676687C>T	uc010zxl.1	+	16	2120	c.2044C>T	c.(2044-2046)CGC>TGC	p.R682C	SLC12A5_uc010zxm.1_RNA|SLC12A5_uc002xrb.2_Missense_Mutation_p.R659C	NM_001134771	NP_001128243	Q9H2X9	S12A5_HUMAN	solute carrier family 12 (potassium-chloride	682					potassium ion transport|sodium ion transport	integral to membrane	potassium:chloride symporter activity			ovary(2)|large_intestine(1)|central_nervous_system(1)|skin(1)	5		Myeloproliferative disorder(115;0.0122)			Bumetanide(DB00887)|Potassium Chloride(DB00761)	TGCCCTCTTACGCCTGGAGGA	0.597		NA											3	24					0	0	0	0
ZNF334	55713	broad.mit.edu	37	20	45131097	45131097	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr20:45131097T>A	uc002xsc.2	-	5	1065	c.881A>T	c.(880-882)GAA>GTA	p.E294V	ZNF334_uc002xsa.2_Missense_Mutation_p.E317V|ZNF334_uc002xsb.2_Missense_Mutation_p.E256V|ZNF334_uc002xsd.2_Missense_Mutation_p.E256V|ZNF334_uc010ghl.2_Missense_Mutation_p.E293V	NM_018102	NP_060572	Q9HCZ1	ZN334_HUMAN	zinc finger protein 334 isoform a	294	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2		Myeloproliferative disorder(115;0.0122)				TTCACTGCATTCATAGGGTCT	0.423		NA											52	241					0	0	0	0
TPTE	7179	broad.mit.edu	37	21	10934054	10934054	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr21:10934054T>A	uc002yip.1	-	16	1291	c.923A>T	c.(922-924)AAT>ATT	p.N308I	TPTE_uc002yis.1_RNA|TPTE_uc002yiq.1_Missense_Mutation_p.N290I|TPTE_uc002yir.1_Missense_Mutation_p.N270I|TPTE_uc010gkv.1_Missense_Mutation_p.N170I	NM_199261	NP_954870	P56180	TPTE_HUMAN	transmembrane phosphatase with tensin homology	308	Phosphatase tensin-type.				signal transduction	integral to membrane	ion channel activity|protein tyrosine phosphatase activity|protein tyrosine/serine/threonine phosphatase activity			ovary(2)|lung(1)|breast(1)|skin(1)	5			Colorectal(6;3.44e-05)|COAD - Colon adenocarcinoma(6;0.00727)|READ - Rectum adenocarcinoma(6;0.0723)	UCEC - Uterine corpus endometrioid carcinoma (6;0.0974)|all cancers(6;2.54e-22)|Epithelial(6;4.21e-19)|OV - Ovarian serous cystadenocarcinoma(6;1.16e-09)|BRCA - Breast invasive adenocarcinoma(6;7.72e-05)|Lung(8;0.000189)|LUSC - Lung squamous cell carcinoma(6;0.00379)|GBM - Glioblastoma multiforme(6;0.00391)|Kidney(17;0.0773)|LUAD - Lung adenocarcinoma(8;0.247)		AGTGGGGACATTATGATCATC	0.299		NA											20	438					0	0	0	0
APP	351	broad.mit.edu	37	21	27269978	27269978	+	Silent	SNP	C	C	T	rs141559720	byFrequency	TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr21:27269978C>T	uc002ylz.2	-	16	2171	c.1971G>A	c.(1969-1971)GGG>GGA	p.G657G	APP_uc011acg.1_Silent_p.G165G|APP_uc010glk.2_Silent_p.G633G|APP_uc002yma.2_Silent_p.G638G|APP_uc011ach.1_Silent_p.G601G|APP_uc002ymb.2_Silent_p.G582G|APP_uc010glj.2_Silent_p.G526G|APP_uc011aci.1_Silent_p.G547G	NM_000484	NP_000475	P05067	A4_HUMAN	amyloid beta A4 protein isoform a precursor	657	Extracellular (Potential).				adult locomotory behavior|axon cargo transport|axon midline choice point recognition|cell adhesion|cellular copper ion homeostasis|collateral sprouting in absence of injury|dendrite development|endocytosis|extracellular matrix organization|G2 phase of mitotic cell cycle|innate immune response|ionotropic glutamate receptor signaling pathway|mating behavior|mRNA polyadenylation|neuron apoptosis|neuron remodeling|Notch signaling pathway|platelet activation|platelet degranulation|positive regulation of mitotic cell cycle|protein phosphorylation|regulation of epidermal growth factor receptor activity|regulation of multicellular organism growth|regulation of synapse structure and activity|regulation of translation|visual learning	axon|cell surface|coated pit|dendritic shaft|dendritic spine|extracellular region|Golgi apparatus|integral to plasma membrane|platelet alpha granule lumen	acetylcholine receptor binding|DNA binding|heparin binding|identical protein binding|metal ion binding|protein binding|protein binding|PTB domain binding|serine-type endopeptidase inhibitor activity			ovary(1)	1		Breast(209;0.00295)				TATTTGTCAACCCAGAACCTG	0.358		NA											31	237					0	0	0	0
GRIK1	2897	broad.mit.edu	37	21	30959875	30959875	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr21:30959875G>T	uc002yno.1	-	12	2068	c.1604C>A	c.(1603-1605)ACC>AAC	p.T535N	GRIK1_uc002ynn.2_Missense_Mutation_p.T520N|GRIK1_uc011acs.1_Missense_Mutation_p.T535N|GRIK1_uc011act.1_Missense_Mutation_p.T396N|GRIK1_uc010glq.1_Missense_Mutation_p.T378N	NM_000830	NP_000821	P39086	GRIK1_HUMAN	glutamate receptor, ionotropic, kainate 1	535	Extracellular (Potential).				central nervous system development|synaptic transmission	cell junction|postsynaptic membrane	kainate selective glutamate receptor activity			large_intestine(1)|ovary(1)|skin(1)	3					L-Glutamic Acid(DB00142)|Topiramate(DB00273)	CCGCACGTAGGTGATGGTAAG	0.483		NA											3	48					0.004672	0.00490017	1	0
DSCR3	10311	broad.mit.edu	37	21	38610786	38610786	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr21:38610786T>C	uc002ywf.1	-	4	565	c.326A>G	c.(325-327)TAT>TGT	p.Y109C	DSCR3_uc010gnm.1_RNA|DSCR3_uc010gnn.1_Missense_Mutation_p.Y67C|DSCR3_uc010gnl.2_Missense_Mutation_p.Y109C|DSCR3_uc011aeg.1_Intron|DSCR3_uc011aeh.1_Intron	NM_006052	NP_006043	O14972	DSCR3_HUMAN	Down syndrome critical region protein 3	109					vacuolar transport	nucleus|retromer complex					0						CACGCCATGATACGTCTCATA	0.448		NA											7	162					0	0	0	0
B3GALT5	10317	broad.mit.edu	37	21	41032541	41032541	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr21:41032541C>A	uc002yyb.1	+	5	647	c.55C>A	c.(55-57)CTT>ATT	p.L19I	B3GALT5_uc002yye.2_Missense_Mutation_p.L19I|B3GALT5_uc002yyi.1_Missense_Mutation_p.L19I|B3GALT5_uc002yyj.1_Missense_Mutation_p.L19I|B3GALT5_uc002yyk.1_Missense_Mutation_p.L19I|B3GALT5_uc002yyl.1_Missense_Mutation_p.L19I|B3GALT5_uc002yym.1_Missense_Mutation_p.L19I	NM_033173	NP_149363	Q9Y2C3	B3GT5_HUMAN	UDP-Gal:betaGlcNAc beta	19	Helical; Signal-anchor for type II membrane protein; (Potential).				protein glycosylation	endoplasmic reticulum|Golgi membrane|integral to membrane	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity			skin(1)	1		Prostate(19;2.55e-06)				TCTGGGGGCTCTTTGTTTGTA	0.398		NA											28	220					1.08e-15	1.27e-15	1	0
S100B	6285	broad.mit.edu	37	21	48022218	48022218	+	Missense_Mutation	SNP	G	G	C			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr21:48022218G>C	uc002zju.1	-	2	222	c.111C>G	c.(109-111)ATC>ATG	p.I37M	S100B_uc002zjv.1_Missense_Mutation_p.I37M	NM_006272	NP_006263	P04271	S100B_HUMAN	S100 calcium-binding protein, beta	37	EF-hand 1.				axonogenesis|cell proliferation|central nervous system development|innate immune response|positive regulation of I-kappaB kinase/NF-kappaB cascade	extracellular region|nucleus|perinuclear region of cytoplasm|ruffle	calcium ion binding|calcium-dependent protein binding|protein homodimerization activity|RAGE receptor binding|S100 beta binding|tau protein binding|zinc ion binding				0	Breast(49;0.247)	Lung NSC(3;0.245)		OV - Ovarian serous cystadenocarcinoma(3;1.84e-06)|Epithelial(3;4.45e-06)|all cancers(3;2.07e-05)|Colorectal(79;0.241)		GCTCATTGTTGATGAGCTCCT	0.443		NA											11	76					0	0	0	0
DNAJB7	150353	broad.mit.edu	37	22	41257198	41257198	+	Silent	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr22:41257198C>T	uc003azj.2	-	1	933	c.801G>A	c.(799-801)GAG>GAA	p.E267E	XPNPEP3_uc011aox.1_Intron|XPNPEP3_uc003azh.2_Intron|XPNPEP3_uc003azi.2_Intron|XPNPEP3_uc011aoy.1_5'Flank|XPNPEP3_uc003azg.1_Intron|XPNPEP3_uc003azf.1_Intron|XPNPEP3_uc010gyh.1_5'Flank	NM_145174	NP_660157	Q7Z6W7	DNJB7_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 7	267					protein folding		heat shock protein binding|unfolded protein binding			ovary(1)	1						ATATACCTCCCTCATCATTGT	0.423		NA											23	136					0	0	0	0
CYB5R3	1727	broad.mit.edu	37	22	43032788	43032788	+	Missense_Mutation	SNP	C	C	T	rs140159332		TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr22:43032788C>T	uc003bcz.2	-	2	170	c.86G>A	c.(85-87)CGC>CAC	p.R29H	CYB5R3_uc010gzc.1_5'UTR|CYB5R3_uc003bcw.2_Missense_Mutation_p.R19H|CYB5R3_uc011aps.1_Missense_Mutation_p.R62H|CYB5R3_uc003bcy.2_Missense_Mutation_p.R6H|CYB5R3_uc003bcx.2_Missense_Mutation_p.R6H	NM_000398	NP_000389	P00387	NB5R3_HUMAN	cytochrome b5 reductase 3 isoform m	29				QRSTP -> RWPRA (in Ref. 10; AAA52307).|R -> G (in Ref. 1; AAA59900).	blood circulation|cholesterol biosynthetic process|water-soluble vitamin metabolic process	endoplasmic reticulum membrane|hemoglobin complex|mitochondrial outer membrane	cytochrome-b5 reductase activity			skin(1)	1					NADH(DB00157)	TGGCGTGGAGCGCTGGAACAG	0.642		NA											7	23					0	0	0	0
GRM7	2917	broad.mit.edu	37	3	7348199	7348199	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr3:7348199C>A	uc003bqm.2	+	4	1167	c.893C>A	c.(892-894)GCA>GAA	p.A298E	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.A298E|GRM7_uc003bql.2_Missense_Mutation_p.A298E|GRM7_uc003bqn.1_5'UTR	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	298	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	ATCCTTGCAGCAGCCAAAAGA	0.438		NA											6	198					0.00198382	0.00209043	1	0
ITGA9	3680	broad.mit.edu	37	3	37555268	37555268	+	Silent	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr3:37555268C>T	uc003chd.2	+	9	965	c.912C>T	c.(910-912)TTC>TTT	p.F304F	ITGA9_uc003chc.2_Silent_p.F304F	NM_002207	NP_002198	Q13797	ITA9_HUMAN	integrin, alpha 9 precursor	304	Extracellular (Potential).|FG-GAP 5.				axon guidance|cell adhesion|integrin-mediated signaling pathway	integrin complex	receptor activity			breast(3)|pancreas(1)|lung(1)|skin(1)	6				KIRC - Kidney renal clear cell carcinoma(284;0.165)|Kidney(284;0.197)		GCTCTTACTTCGGCTCCTCCT	0.552		NA											15	82					0	0	0	0
RBM6	10180	broad.mit.edu	37	3	50095359	50095359	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr3:50095359G>A	uc003cyc.2	+	9	2025	c.1892G>A	c.(1891-1893)AGG>AAG	p.R631K	RBM6_uc011bdh.1_RNA|RBM6_uc010hlc.1_Missense_Mutation_p.R150K|RBM6_uc003cyd.2_Missense_Mutation_p.R109K|RBM6_uc003cye.2_Missense_Mutation_p.R109K|RBM6_uc011bdi.1_5'UTR|RBM6_uc010hld.1_RNA|RBM6_uc010hle.1_RNA|RBM6_uc010hlf.1_RNA	NM_005777	NP_005768	P78332	RBM6_HUMAN	RNA binding motif protein 6	631					RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		CCTTCTCGAAGGGAAGGGCCA	0.512		NA											10	61					0	0	0	0
BAP1	8314	broad.mit.edu	37	3	52441440	52441440	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr3:52441440C>T	uc003ddx.2	-	6	527	c.412G>A	c.(412-414)GCC>ACC	p.A138T	BAP1_uc010hmh.2_5'Flank	NM_004656	NP_004647	Q92560	BAP1_HUMAN	BRCA1 associated protein-1	138					monoubiquitinated histone H2A deubiquitination|negative regulation of cell proliferation|protein K48-linked deubiquitination|regulation of cell cycle|regulation of cell growth|ubiquitin-dependent protein catabolic process	cytoplasm|nucleolus|PR-DUB complex	chromatin binding|protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity	p.?(2)		pleura(32)|eye(28)|lung(2)|ovary(2)|breast(1)	65				BRCA - Breast invasive adenocarcinoma(193;1.72e-05)|Kidney(197;0.0018)|KIRC - Kidney renal clear cell carcinoma(197;0.00203)|OV - Ovarian serous cystadenocarcinoma(275;0.0277)		TGGGCCTTGGCCAACTCCGGG	0.517		NA	N|Mis|F|S|O		uveal melanoma|breast|NSCLC								5	162					0	0	0	0
C3orf63	23272	broad.mit.edu	37	3	56681252	56681252	+	Splice_Site	SNP	C	C	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr3:56681252C>A	uc003did.3	-	14	1615	c.1514_splice	c.e14-1	p.S505_splice	C3orf63_uc003dic.3_Splice_Site_p.S109_splice|C3orf63_uc003die.3_Splice_Site_p.S505_splice	NM_015224	NP_056039	Q9UK61	CC063_HUMAN	retinoblastoma-associated protein 140 isoform b											ovary(3)|kidney(1)|central_nervous_system(1)	5				KIRC - Kidney renal clear cell carcinoma(284;0.0126)|Kidney(284;0.0147)		CCTTTTTGTGCTGTAAATAAA	0.318		NA											17	88					2.94e-08	3.32e-08	1	0
PLS1	5357	broad.mit.edu	37	3	142388320	142388320	+	Silent	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr3:142388320C>T	uc010huv.2	+	3	318	c.159C>T	c.(157-159)CGC>CGT	p.R53R	PLS1_uc003euz.2_Silent_p.R53R|PLS1_uc003eva.2_Silent_p.R53R	NM_001145319	NP_001138791	Q14651	PLSI_HUMAN	plastin 1	53	EF-hand 2.					cytoplasm	actin filament binding|calcium ion binding|structural constituent of cytoskeleton			ovary(1)	1						ACAAGGTGCGCGAGATTGTGG	0.408		NA											26	184					0	0	0	0
ZIC4	84107	broad.mit.edu	37	3	147114229	147114229	+	Missense_Mutation	SNP	T	T	G			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr3:147114229T>G	uc003ewd.1	-	3	371	c.98A>C	c.(97-99)CAG>CCG	p.Q33P	ZIC4_uc003ewc.1_5'UTR|ZIC4_uc011bno.1_Missense_Mutation_p.Q83P	NM_032153	NP_115529	Q8N9L1	ZIC4_HUMAN	zinc finger protein of the cerebellum 4	33						nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|central_nervous_system(1)	2						GGCGGTGAGCTGGGGGCCATG	0.692		NA											9	37					0	0	0	0
PTX3	5806	broad.mit.edu	37	3	157160520	157160520	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr3:157160520C>T	uc003fbl.3	+	3	1041	c.898C>T	c.(898-900)CAC>TAC	p.H300Y	VEPH1_uc003fbj.1_Intron|VEPH1_uc003fbk.1_Intron|VEPH1_uc010hvu.1_Intron	NM_002852	NP_002843	P26022	PTX3_HUMAN	pentraxin 3 precursor	300	Pentaxin.				inflammatory response	extracellular region				central_nervous_system(1)	1			Lung(72;0.0272)|LUSC - Lung squamous cell carcinoma(72;0.0461)			GGCCACAGGTCACATTGTTCC	0.532		NA											9	83					0	0	0	0
SLITRK3	22865	broad.mit.edu	37	3	164908254	164908254	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr3:164908254T>C	uc003fej.3	-	2	809	c.365A>G	c.(364-366)AAT>AGT	p.N122S	SLITRK3_uc003fek.2_Missense_Mutation_p.N122S	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	122	LRR 2.|Extracellular (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						CTTAAGACCATTGAAAGCTCC	0.348		NA								HNSCC(40;0.11)			22	106					0	0	0	0
PPAT	5471	broad.mit.edu	37	4	57267496	57267496	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr4:57267496C>T	uc003hbr.2	-	7	1088	c.886G>A	c.(886-888)GAC>AAC	p.D296N		NM_002703	NP_002694	Q06203	PUR1_HUMAN	phosphoribosyl pyrophosphate amidotransferase	296					glutamine metabolic process|nucleoside metabolic process|purine base biosynthetic process|purine ribonucleoside monophosphate biosynthetic process	cytosol	4 iron, 4 sulfur cluster binding|amidophosphoribosyltransferase activity|metal ion binding				0	Glioma(25;0.08)|all_neural(26;0.101)				L-Glutamine(DB00130)|Thioguanine(DB00352)	ATCTACTTACCTTCGAACATA	0.353		NA											19	271					0	0	0	0
YTHDC1	91746	broad.mit.edu	37	4	69184292	69184292	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr4:69184292T>C	uc003hdx.2	-	15	2122	c.1769A>G	c.(1768-1770)AAT>AGT	p.N590S	YTHDC1_uc003hdy.2_Missense_Mutation_p.N572S	NM_001031732	NP_001026902	Q96MU7	YTDC1_HUMAN	splicing factor YT521-B isoform 1	590										upper_aerodigestive_tract(1)|ovary(1)	2						CACATAATCATTGTAGGACTA	0.289		NA											7	64					0	0	0	0
FRAS1	80144	broad.mit.edu	37	4	79285132	79285132	+	Silent	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr4:79285132C>T	uc003hlb.2	+	22	3086	c.2646C>T	c.(2644-2646)CTC>CTT	p.L882L	FRAS1_uc003hkw.2_Silent_p.L882L	NM_025074	NP_079350	Q86XX4	FRAS1_HUMAN	Fraser syndrome 1	882	FU 10.|Extracellular (Potential).				cell communication	integral to membrane|plasma membrane	metal ion binding			large_intestine(5)	5						ACACCAACCTCGTGCTGTCCC	0.527		NA											3	24					0	0	0	0
HERC3	8916	broad.mit.edu	37	4	89591032	89591032	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr4:89591032G>A	uc003hrw.1	+	15	1821	c.1655G>A	c.(1654-1656)TGC>TAC	p.C552Y	HERC3_uc011cdn.1_Missense_Mutation_p.C434Y|HERC3_uc011cdo.1_5'UTR	NM_014606	NP_055421	Q15034	HERC3_HUMAN	hect domain and RLD 3	552					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasmic membrane-bounded vesicle	ubiquitin-protein ligase activity			lung(2)|prostate(1)|skin(1)	4				OV - Ovarian serous cystadenocarcinoma(123;0.000319)		TCTCAGGTATGCCCGAAATAT	0.363		NA											20	137					0	0	0	0
PAPSS1	9061	broad.mit.edu	37	4	108608212	108608212	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr4:108608212C>T	uc003hyk.2	-	4	617	c.533G>A	c.(532-534)CGG>CAG	p.R178Q	PAPSS1_uc011cfh.1_Intron	NM_005443	NP_005434	O43252	PAPS1_HUMAN	3'-phosphoadenosine 5'-phosphosulfate synthase	178	Adenylyl-sulfate kinase.				3'-phosphoadenosine 5'-phosphosulfate biosynthetic process|skeletal system development|sulfate assimilation|xenobiotic metabolic process	cytosol	adenylylsulfate kinase activity|ATP binding|sulfate adenylyltransferase (ATP) activity			ovary(1)	1		Hepatocellular(203;0.217)		OV - Ovarian serous cystadenocarcinoma(123;5.49e-05)		TTCTCCTGCCCGGGCTTTTTT	0.363		NA											11	238					0	0	0	0
MORF4	10934	broad.mit.edu	37	4	174537544	174537545	+	Missense_Mutation	DNP	CA	CA	GC			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr4:174537544_174537545CA>GC	uc011cke.1	-	1	250_251	c.250_251TG>GC	c.(250-252)TGG>GCG	p.W84A		NM_006792	NP_006783			mortality factor 4												0		Prostate(90;0.00201)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_neural(102;0.0765)|all_hematologic(60;0.107)		all cancers(43;1.88e-18)|Epithelial(43;1.19e-16)|OV - Ovarian serous cystadenocarcinoma(60;1.38e-09)|STAD - Stomach adenocarcinoma(60;0.00273)|GBM - Glioblastoma multiforme(59;0.0064)|LUSC - Lung squamous cell carcinoma(193;0.0903)|Kidney(143;0.249)		AATTAAGTCCCAGTCATCAACA	0.391		NA											31	253					0	0	0	0
HEATR7B2	133558	broad.mit.edu	37	5	41018010	41018010	+	Silent	SNP	G	G	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr5:41018010G>A	uc003jmj.3	-	28	3316	c.2826C>T	c.(2824-2826)ACC>ACT	p.T942T	HEATR7B2_uc003jmi.3_Silent_p.T497T	NM_173489	NP_775760	Q7Z745	HTRB2_HUMAN	HEAT repeat family member 7B2	942							binding			ovary(6)|central_nervous_system(2)	8						TGGTGGGCAGGGTATCACAGG	0.483		NA											7	12					0	0	0	0
PPIP5K2	23262	broad.mit.edu	37	5	102487035	102487035	+	Nonsense_Mutation	SNP	A	A	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr5:102487035A>T	uc003kod.3	+	9	1504	c.985A>T	c.(985-987)AAA>TAA	p.K329*	PPIP5K2_uc011cva.1_RNA|PPIP5K2_uc003koe.2_Nonsense_Mutation_p.K329*|PPIP5K2_uc010jbo.1_Nonsense_Mutation_p.K251*	NM_015216	NP_056031	O43314	VIP2_HUMAN	Histidine acid phosphatase domain containing 1	329					inositol metabolic process	cytosol	acid phosphatase activity|ATP binding|diphosphoinositol-pentakisphosphate kinase activity|inositol 1,3,4,5,6-pentakisphosphate kinase activity|inositol hexakisphosphate 5-kinase activity			ovary(1)|skin(1)	2						CAGTTTTGTGAAAAATTCCAT	0.308		NA											31	131					0	0	0	0
C5orf15	56951	broad.mit.edu	37	5	133295208	133295208	+	Missense_Mutation	SNP	T	T	C			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr5:133295208T>C	uc003kyo.2	-	2	774	c.643A>G	c.(643-645)ATT>GTT	p.I215V		NM_020199	NP_064584	Q8NC54	KCT2_HUMAN	keratinocytes associated transmembrane protein 2	215	Helical; (Potential).					integral to membrane					0			KIRC - Kidney renal clear cell carcinoma(527;0.00806)|Kidney(363;0.02)			TGATATGTAATGTAAACAACA	0.289		NA											12	68					0	0	0	0
HARS2	23438	broad.mit.edu	37	5	140073602	140073602	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr5:140073602G>A	uc003lgx.2	+	3	482	c.266G>A	c.(265-267)GGA>GAA	p.G89E	HARS_uc003lgv.2_5'Flank|HARS_uc011czm.1_5'Flank|HARS_uc003lgw.2_5'Flank|HARS_uc011czn.1_5'Flank|HARS_uc010jfu.2_5'Flank|HARS_uc011czo.1_5'Flank|HARS_uc011czp.1_5'Flank|HARS_uc011czq.1_5'Flank|HARS2_uc010jfv.1_Missense_Mutation_p.G19E|HARS2_uc011czr.1_Missense_Mutation_p.G64E|HARS2_uc011czs.1_Missense_Mutation_p.G19E|HARS2_uc011czt.1_Intron|HARS2_uc011czu.1_5'Flank	NM_012208	NP_036340	P49590	SYHM_HUMAN	histidyl-tRNA synthetase 2 precursor	89					histidyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|histidine-tRNA ligase activity				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AAACGTCATGGAGCAAAGGGG	0.478		NA											59	245					0	0	0	0
PCDHGB7	56099	broad.mit.edu	37	5	140798230	140798230	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr5:140798230C>A	uc003lkn.1	+	1	949	c.804C>A	c.(802-804)GAC>GAA	p.D268E	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc003lkl.1_Intron|PCDHGB7_uc003lkm.2_Missense_Mutation_p.D268E|PCDHGA11_uc003lko.1_5'Flank|PCDHGA11_uc003lkp.1_5'Flank|PCDHGA11_uc003lkq.1_5'Flank	NM_018927	NP_061750	Q9Y5F8	PCDGJ_HUMAN	protocadherin gamma subfamily B, 7 isoform 1	268	Extracellular (Potential).|Cadherin 3.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			AGGCCACTGACCAGGACGAGG	0.532		NA											13	68					0.000151284	0.000161681	1	0
CRISP2	7180	broad.mit.edu	37	6	49667570	49667570	+	Missense_Mutation	SNP	C	C	G			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr6:49667570C>G	uc003ozq.2	-	6	474	c.218G>C	c.(217-219)AGG>ACG	p.R73T	CRISP2_uc003ozl.2_Missense_Mutation_p.R73T|CRISP2_uc003ozn.2_Missense_Mutation_p.R73T|CRISP2_uc003ozr.2_Missense_Mutation_p.R73T|CRISP2_uc003ozo.2_Missense_Mutation_p.R73T|CRISP2_uc003ozm.2_Missense_Mutation_p.R73T|CRISP2_uc003ozp.2_Missense_Mutation_p.R73T	NM_001142408	NP_001135880	P16562	CRIS2_HUMAN	cysteine-rich secretory protein 2 precursor	73						extracellular space				skin(1)	1	Lung NSC(77;0.0161)		KIRC - Kidney renal clear cell carcinoma(2;0.106)|Kidney(12;0.156)			GTTTGCCCACCTTTGGGCATT	0.259		NA											12	78					0	0	0	0
MICAL1	64780	broad.mit.edu	37	6	109766112	109766112	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr6:109766112C>T	uc003ptj.2	-	22	3222	c.2968G>A	c.(2968-2970)GAG>AAG	p.E990K	MICAL1_uc003ptk.2_Missense_Mutation_p.E990K|MICAL1_uc010kdr.2_Missense_Mutation_p.E904K|MICAL1_uc011eaq.1_Missense_Mutation_p.E1009K	NM_022765	NP_073602	Q8TDZ2	MICA1_HUMAN	microtubule associated monoxygenase, calponin	990					cytoskeleton organization|signal transduction	cytoplasm|intermediate filament	SH3 domain binding|zinc ion binding			breast(2)|ovary(1)	3		all_cancers(87;0.000189)|Acute lymphoblastic leukemia(125;3.07e-08)|all_hematologic(75;3.33e-06)|all_epithelial(87;0.00686)|Lung SC(18;0.0743)|Colorectal(196;0.101)|all_lung(197;0.149)		Epithelial(106;0.0142)|all cancers(137;0.0197)|OV - Ovarian serous cystadenocarcinoma(136;0.0233)|BRCA - Breast invasive adenocarcinoma(108;0.0574)		ATCATGAGCTCGGCCTCCTCA	0.552		NA											5	242					0	0	0	0
SOD2	6648	broad.mit.edu	37	6	160106063	160106063	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr6:160106063C>T	uc003qsg.2	-	4	500	c.346G>A	c.(346-348)GAG>AAG	p.E116K	SOD2_uc003qsh.2_Missense_Mutation_p.E77K|SOD2_uc003qsi.1_Missense_Mutation_p.E116K|SOD2_uc011efu.1_Intron|SOD2_uc011efv.1_Missense_Mutation_p.E77K	NM_001024465	NP_001019636	P04179	SODM_HUMAN	manganese superoxide dismutase isoform A	116					age-dependent response to reactive oxygen species|negative regulation of neuron apoptosis|oxygen homeostasis|protein homotetramerization|regulation of transcription from RNA polymerase II promoter|release of cytochrome c from mitochondria|removal of superoxide radicals|vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure		manganese ion binding|superoxide dismutase activity				0		Breast(66;0.000776)|Ovarian(120;0.0303)|Prostate(117;0.103)		OV - Ovarian serous cystadenocarcinoma(65;1.4e-18)|BRCA - Breast invasive adenocarcinoma(81;5.77e-06)		TCCAGCAACTCCCCTATTAAA	0.373		NA											7	49					0	0	0	0
EIF3B	8662	broad.mit.edu	37	7	2409152	2409153	+	Missense_Mutation	DNP	GC	GC	TT			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr7:2409152_2409153GC>TT	uc003slx.2	+	10	1532_1533	c.1449_1450GC>TT	c.(1447-1452)GTGCCT>GTTTCT	p.P484S	EIF3B_uc003sly.2_Missense_Mutation_p.P484S|EIF3B_uc003sma.2_Missense_Mutation_p.P212S	NM_003751	NP_003742	P55884	EIF3B_HUMAN	eukaryotic translation initiation factor 3,	484					regulation of translational initiation	cytosol|eukaryotic translation initiation factor 3 complex	nucleotide binding|protein complex scaffold|translation initiation factor activity				0		Ovarian(82;0.0253)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0833)|OV - Ovarian serous cystadenocarcinoma(56;7.76e-14)		CCTTCTGGGTGCCTGAAGACAA	0.47		NA											48	338					0	0	0	0
SEMA3A	10371	broad.mit.edu	37	7	83606507	83606507	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr7:83606507G>A	uc003uhz.2	-	15	1973	c.1658C>T	c.(1657-1659)ACA>ATA	p.T553I		NM_006080	NP_006071	Q14563	SEM3A_HUMAN	semaphorin 3A precursor	553					axon guidance	extracellular region|membrane	receptor activity			ovary(2)|breast(1)|kidney(1)	4						TTGTCGTCTTGTGCGTCTGAA	0.343		NA											18	120					0	0	0	0
MUC17	140453	broad.mit.edu	37	7	100679879	100679879	+	Missense_Mutation	SNP	C	C	T	rs71273404		TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr7:100679879C>T	uc003uxp.1	+	3	5235	c.5182C>T	c.(5182-5184)CGT>TGT	p.R1728C	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	1728	Extracellular (Potential).|59 X approximate tandem repeats.|27.|Ser-rich.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TACTGAAGCCCGTTCATCTCC	0.498		NA											58	353					0	0	0	0
MUC17	140453	broad.mit.edu	37	7	100683048	100683048	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr7:100683048C>A	uc003uxp.1	+	3	8404	c.8351C>A	c.(8350-8352)ACT>AAT	p.T2784N	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	2784	Extracellular (Potential).|Ser-rich.|59 X approximate tandem repeats.|45.					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					CCTGTCACCACTTCTACTGAA	0.478		NA											9	340					2.18e-05	2.36e-05	1	0
MUC17	140453	broad.mit.edu	37	7	100686329	100686329	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr7:100686329A>G	uc003uxp.1	+	3	11685	c.11632A>G	c.(11632-11634)ACT>GCT	p.T3878A	MUC17_uc010lho.1_RNA	NM_001040105	NP_001035194	Q685J3	MUC17_HUMAN	mucin 17 precursor	3878	Extracellular (Potential).					extracellular region|integral to membrane|plasma membrane	extracellular matrix constituent, lubricant activity			ovary(14)|skin(8)|breast(3)|lung(2)	27	Lung NSC(181;0.136)|all_lung(186;0.182)					TCCATTAACAACTCTCCTTGT	0.468		NA											38	185					0	0	0	0
MOGAT3	346606	broad.mit.edu	37	7	100843751	100843751	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr7:100843751A>T	uc003uyc.2	-	2	322	c.155T>A	c.(154-156)CTC>CAC	p.L52H	MOGAT3_uc010lhr.2_Missense_Mutation_p.L52H	NM_178176	NP_835470	Q86VF5	MOGT3_HUMAN	monoacylglycerol O-acyltransferase 3	52	Helical; (Potential).				glycerol metabolic process|lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity|diacylglycerol O-acyltransferase activity			ovary(2)	2	Lung NSC(181;0.168)|all_lung(186;0.215)					GAAGGGCCAGAGTGACGTGAA	0.527		NA											7	27					0	0	0	0
LRRN3	54674	broad.mit.edu	37	7	110762919	110762919	+	Silent	SNP	C	C	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr7:110762919C>A	uc003vft.3	+	4	1137	c.91C>A	c.(91-93)CGG>AGG	p.R31R	IMMP2L_uc003vfq.1_Intron|IMMP2L_uc010ljr.1_Intron|IMMP2L_uc003vfr.2_Intron|LRRN3_uc003vfu.3_Silent_p.R31R|LRRN3_uc003vfs.3_Silent_p.R31R	NM_001099660	NP_001093130	Q9H3W5	LRRN3_HUMAN	leucine rich repeat neuronal 3 precursor	31	Extracellular (Potential).|LRRNT.					integral to membrane				skin(3)|ovary(2)|pancreas(2)|central_nervous_system(1)	8				UCEC - Uterine corpus endometrioid carcinoma (4;0.245)|LUSC - Lung squamous cell carcinoma(290;0.0715)|Lung(3;0.0864)|STAD - Stomach adenocarcinoma(3;0.125)		GGATTGTCCACGGTTATGTAC	0.408		NA											21	148					2.38e-13	2.73e-13	1	0
NRF1	4899	broad.mit.edu	37	7	129297354	129297354	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr7:129297354G>T	uc003voz.2	+	2	280	c.163G>T	c.(163-165)GAC>TAC	p.D55Y	NRF1_uc003vpa.2_Missense_Mutation_p.D55Y|NRF1_uc011kpa.1_5'UTR|NRF1_uc003vpb.2_Missense_Mutation_p.D55Y	NM_005011	NP_005002	Q16656	NRF1_HUMAN	nuclear respiratory factor 1	55	Dimerization.|Asp/Glu-rich (acidic).				generation of precursor metabolites and energy|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1						CTCTTACGATGACTCAGATAT	0.478		NA											9	124					4.69e-08	5.26e-08	1	0
ST18	9705	broad.mit.edu	37	8	53055550	53055550	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr8:53055550G>A	uc003xqz.2	-	12	2264	c.2108C>T	c.(2107-2109)GCC>GTC	p.A703V	ST18_uc011ldq.1_Missense_Mutation_p.A350V|ST18_uc011ldr.1_Missense_Mutation_p.A668V|ST18_uc011lds.1_Missense_Mutation_p.A608V|ST18_uc003xra.2_Missense_Mutation_p.A703V	NM_014682	NP_055497	O60284	ST18_HUMAN	suppression of tumorigenicity 18	703						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(4)|skin(1)	5		Lung NSC(129;0.131)|all_epithelial(80;0.217)|all_lung(136;0.229)				TGGTATAGAGGCCTCTCCAGG	0.418		NA											25	193					0	0	0	0
ATP6V1H	51606	broad.mit.edu	37	8	54730074	54730074	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr8:54730074A>G	uc003xrl.2	-	5	475	c.323T>C	c.(322-324)GTT>GCT	p.V108A	ATP6V1H_uc003xrk.2_Missense_Mutation_p.V68A|ATP6V1H_uc003xrm.2_Missense_Mutation_p.V108A|ATP6V1H_uc003xrn.2_Missense_Mutation_p.V108A|ATP6V1H_uc011ldv.1_Missense_Mutation_p.V28A|ATP6V1H_uc010lyd.2_Missense_Mutation_p.V44A	NM_213620	NP_998785	Q9UI12	VATH_HUMAN	ATPase, H+ transporting, lysosomal 50/57kDa, V1	108					ATP hydrolysis coupled proton transport|cellular iron ion homeostasis|endocytosis|insulin receptor signaling pathway|interspecies interaction between organisms|regulation of defense response to virus by virus|transferrin transport|vacuolar acidification|viral reproduction	cytosol|plasma membrane|vacuolar proton-transporting V-type ATPase, V1 domain	enzyme regulator activity|protein binding|proton-transporting ATPase activity, rotational mechanism				0		all_epithelial(80;0.0487)|Lung NSC(129;0.109)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;2.79e-06)|Epithelial(17;0.000629)|all cancers(17;0.00359)			GAAAATGCTAACACGCTGATG	0.413		NA											13	51					0	0	0	0
RALYL	138046	broad.mit.edu	37	8	85774590	85774590	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr8:85774590G>A	uc003ycq.3	+	7	889	c.473G>A	c.(472-474)CGT>CAT	p.R158H	RALYL_uc003ycr.3_Missense_Mutation_p.R158H|RALYL_uc003ycs.3_Missense_Mutation_p.R158H|RALYL_uc010lzy.2_Missense_Mutation_p.R147H|RALYL_uc003yct.3_Missense_Mutation_p.R171H|RALYL_uc003ycu.3_Missense_Mutation_p.R85H|RALYL_uc003ycv.3_Missense_Mutation_p.R70H	NM_001100392	NP_001093862	Q86SE5	RALYL_HUMAN	RALY RNA binding protein-like isoform 2	158							identical protein binding|nucleotide binding|RNA binding			ovary(1)	1						CCGCTGAAGCGTCCCAGAGTG	0.507		NA											7	38					0	0	0	0
VPS13B	157680	broad.mit.edu	37	8	100523369	100523369	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr8:100523369A>T	uc003yiv.2	+	29	4448	c.4337A>T	c.(4336-4338)CAT>CTT	p.H1446L	VPS13B_uc003yiw.2_Missense_Mutation_p.H1421L|VPS13B_uc003yix.1_Missense_Mutation_p.H916L	NM_017890	NP_060360	Q7Z7G8	VP13B_HUMAN	vacuolar protein sorting 13B isoform 5	1446					protein transport					ovary(7)|skin(4)|lung(3)|central_nervous_system(2)|pancreas(2)|breast(1)|kidney(1)	20	Breast(36;3.73e-07)		OV - Ovarian serous cystadenocarcinoma(57;0.00636)			CATCAGCAGCATGGATTCCTC	0.333		NA											37	161					0	0	0	0
DCAF13	25879	broad.mit.edu	37	8	104432504	104432504	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr8:104432504A>G	uc003yln.2	+	2	816	c.539A>G	c.(538-540)TAT>TGT	p.Y180C	DCAF13_uc003ylm.1_Intron|DCAF13_uc003ylo.2_5'UTR	NM_015420	NP_056235	Q9NV06	DCA13_HUMAN	WD repeats and SOF1 domain containing	28					rRNA processing	CUL4 RING ubiquitin ligase complex|nucleolus|ribonucleoprotein complex				breast(1)	1						CCAAGAAACTATGATCCTGCT	0.358		NA											17	107					0	0	0	0
FAM91A1	157769	broad.mit.edu	37	8	124796733	124796733	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr8:124796733A>G	uc003yqv.2	+	9	788	c.727A>G	c.(727-729)ATG>GTG	p.M243V	FAM91A1_uc011lik.1_Missense_Mutation_p.M243V|FAM91A1_uc011lil.1_Missense_Mutation_p.M1V	NM_144963	NP_659400	Q658Y4	F91A1_HUMAN	hypothetical protein LOC157769	243										ovary(1)|central_nervous_system(1)	2	Lung NSC(37;8.76e-13)|Ovarian(258;0.00744)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00192)			AGGTTTTGTAATGAATCGAGT	0.308		NA											5	115					0	0	0	0
PHF20L1	51105	broad.mit.edu	37	8	133851650	133851650	+	Missense_Mutation	SNP	A	A	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr8:133851650A>T	uc003ytt.2	+	18	2535	c.2210A>T	c.(2209-2211)AAA>ATA	p.K737I	PHF20L1_uc011lja.1_Missense_Mutation_p.K711I	NM_016018	NP_057102	A8MW92	P20L1_HUMAN	PHD finger protein 20-like 1 isoform 1	737							nucleic acid binding|zinc ion binding			ovary(2)	2	all_neural(3;2.72e-06)|Medulloblastoma(3;7.08e-05)|Ovarian(258;0.00438)|Esophageal squamous(12;0.00507)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;4.46e-05)			TGGAGTGCAAAATATCGTTAT	0.373		NA											7	154					0	0	0	0
COL22A1	169044	broad.mit.edu	37	8	139601676	139601676	+	Silent	SNP	G	G	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr8:139601676G>A	uc003yvd.2	-	65	5148	c.4701C>T	c.(4699-4701)CCC>CCT	p.P1567P	COL22A1_uc011ljo.1_Silent_p.P847P	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1567	Pro-rich.|Gly-rich.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CAGGTTCCCCGGGTTGACCTG	0.577		NA								HNSCC(7;0.00092)			3	26					0	0	0	0
FREM1	158326	broad.mit.edu	37	9	14801743	14801743	+	Missense_Mutation	SNP	A	A	G			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr9:14801743A>G	uc003zlm.2	-	20	4191	c.3601T>C	c.(3601-3603)TTT>CTT	p.F1201L	FREM1_uc010mic.2_RNA	NM_144966	NP_659403	Q5H8C1	FREM1_HUMAN	FRAS1 related extracellular matrix 1 precursor	1201	CSPG 8.				cell communication|multicellular organismal development	basement membrane|integral to membrane	metal ion binding|sugar binding			ovary(2)|breast(2)|pancreas(1)	5				GBM - Glioblastoma multiforme(50;3.53e-06)		TCTTTGCTAAACCCCCTATCG	0.522		NA											12	129					0	0	0	0
KIF24	347240	broad.mit.edu	37	9	34255735	34255735	+	Silent	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr9:34255735C>T	uc003zua.3	-	11	3990	c.3870G>A	c.(3868-3870)GCG>GCA	p.A1290A	KIF24_uc010mkb.2_Intron	NM_194313	NP_919289	Q5T7B8	KIF24_HUMAN	kinesin family member 24	1290					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			central_nervous_system(1)	1			LUSC - Lung squamous cell carcinoma(29;0.0107)			CAACTTACTGCGCTTGCTCCA	0.567		NA									OREG0019148	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	38					0	0	0	0
WNK2	65268	broad.mit.edu	37	9	95993222	95993222	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr9:95993222C>T	uc004ati.1	+	3	907	c.907C>T	c.(907-909)CGG>TGG	p.R303W	WNK2_uc011lud.1_Missense_Mutation_p.R303W|WNK2_uc004atj.2_Missense_Mutation_p.R303W|WNK2_uc010mrc.1_Missense_Mutation_p.R303W|WNK2_uc010mrd.1_5'UTR	NM_006648	NP_006639	Q9Y3S1	WNK2_HUMAN	WNK lysine deficient protein kinase 2	303	Protein kinase.				intracellular protein kinase cascade		ATP binding|protein binding|protein serine/threonine kinase activity			lung(4)|stomach(3)|ovary(2)|large_intestine(1)|central_nervous_system(1)|breast(1)	12						CAGCTGGTGCCGGCAGATCCT	0.587		NA											25	77					0	0	0	0
GPR107	57720	broad.mit.edu	37	9	132854651	132854651	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr9:132854651G>A	uc004bze.2	+	9	1081	c.854G>A	c.(853-855)CGA>CAA	p.R285Q	GPR107_uc004bzb.2_Missense_Mutation_p.R96Q|GPR107_uc004bzc.3_RNA|GPR107_uc011mbx.1_Missense_Mutation_p.R285Q|GPR107_uc004bzd.2_Missense_Mutation_p.R285Q	NM_001136557	NP_001130029	Q5VW38	GP107_HUMAN	G protein-coupled receptor 107 isoform 1	285						integral to membrane				upper_aerodigestive_tract(1)	1		Ovarian(14;0.000531)				CATATCCTTCGAAAACGACGG	0.423		NA											62	170					0	0	0	0
TPRN	286262	broad.mit.edu	37	9	140087090	140087090	+	Silent	SNP	G	G	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr9:140087090G>A	uc004clt.2	-	2	1596	c.1596C>T	c.(1594-1596)TCC>TCT	p.S532S	TPRN_uc004clu.2_Silent_p.S532S	NM_173691	NP_775962	Q4KMQ1	TPRN_HUMAN	hypothetical protein LOC286262 isoform 2	593	Glu-rich.				sensory perception of sound	stereocilium					0						GGGAGCTCTCGGAAGGGTACT	0.358		NA											5	91					0	0	0	0
FRMPD4	9758	broad.mit.edu	37	X	12701661	12701661	+	Silent	SNP	C	C	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chrX:12701661C>A	uc004cuz.1	+	6	1034	c.528C>A	c.(526-528)GTC>GTA	p.V176V	FRMPD4_uc011mij.1_Silent_p.V168V	NM_014728	NP_055543	Q14CM0	FRPD4_HUMAN	FERM and PDZ domain containing 4	176					positive regulation of synapse structural plasticity	cytoskeleton|dendritic spine	phosphatidylinositol-4,5-bisphosphate binding|protein binding			central_nervous_system(5)|ovary(3)|skin(2)|large_intestine(1)|lung(1)|pancreas(1)	13						CCAATCCTGTCAAAGTACGCT	0.418		NA											14	90					2.32e-05	2.51e-05	1	0
PHKA2	5256	broad.mit.edu	37	X	18972501	18972501	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chrX:18972501G>T	uc004cyv.3	-	2	538	c.108C>A	c.(106-108)AGC>AGA	p.S36R	PHKA2_uc010nfh.1_RNA|PHKA2_uc010nfi.1_5'UTR	NM_000292	NP_000283	P46019	KPB2_HUMAN	phosphorylase kinase, alpha 2 (liver)	36					glucose metabolic process|glycogen catabolic process	cytosol|phosphorylase kinase complex|plasma membrane	calmodulin binding|glucan 1,4-alpha-glucosidase activity|phosphorylase kinase activity			ovary(1)|central_nervous_system(1)	2	Hepatocellular(33;0.183)					TCTGCTCATGGCTGGCTGACA	0.562		NA											25	107					4.27e-12	4.89e-12	1	0
RPS6KA3	6197	broad.mit.edu	37	X	20211697	20211697	+	Missense_Mutation	SNP	T	T	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chrX:20211697T>A	uc004czu.2	-	7	501	c.501A>T	c.(499-501)GAA>GAT	p.E167D	RPS6KA3_uc011mjk.1_Missense_Mutation_p.E138D|RPS6KA3_uc004czv.2_Missense_Mutation_p.E155D|RPS6KA3_uc011mjl.1_Missense_Mutation_p.E139D|RPS6KA3_uc011mjm.1_Missense_Mutation_p.E139D	NM_004586	NP_004577	P51812	KS6A3_HUMAN	ribosomal protein S6 kinase, 90kDa, polypeptide	167	Protein kinase 1.				axon guidance|central nervous system development|innate immune response|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|nerve growth factor receptor signaling pathway|skeletal system development|stress-activated MAPK cascade|synaptic transmission|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cytosol|nucleoplasm	ATP binding|caspase inhibitor activity|magnesium ion binding|protein serine/threonine kinase activity			central_nervous_system(4)|stomach(1)|ovary(1)|lung(1)|breast(1)	8						TGACATCTTCTTCTGTGAACA	0.294		NA											6	78					0	0	0	0
MED12	9968	broad.mit.edu	37	X	70349995	70349995	+	Silent	SNP	T	T	C			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chrX:70349995T>C	uc004dyy.2	+	28	4177	c.3978T>C	c.(3976-3978)TAT>TAC	p.Y1326Y	MED12_uc011mpq.1_Silent_p.Y1326Y|MED12_uc004dyz.2_Silent_p.Y1326Y|MED12_uc004dza.2_Silent_p.Y1173Y|MED12_uc010nla.2_5'UTR	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	1326					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					TCATTTGCTATCCACATCGAC	0.572		NA											4	29					0	0	0	0
ATRX	546	broad.mit.edu	37	X	76814235	76814235	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chrX:76814235C>T	uc004ecp.3	-	29	6641	c.6409G>A	c.(6409-6411)GCT>ACT	p.A2137T	ATRX_uc004ecq.3_Missense_Mutation_p.A2099T|ATRX_uc004eco.3_Missense_Mutation_p.A1922T	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	2137	Helicase C-terminal.				DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	TTCCAAGAAGCGTCGAATATA	0.353		NA	Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						28	170					0	0	0	0
ATRX	546	broad.mit.edu	37	X	76939409	76939409	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chrX:76939409C>T	uc004ecp.3	-	9	1571	c.1339G>A	c.(1339-1341)GAA>AAA	p.E447K	ATRX_uc004ecq.3_Missense_Mutation_p.E409K|ATRX_uc004eco.3_Missense_Mutation_p.E232K|ATRX_uc004ecr.2_Missense_Mutation_p.E408K|ATRX_uc010nlx.1_Missense_Mutation_p.E447K|ATRX_uc010nly.1_Missense_Mutation_p.E392K	NM_000489	NP_000480	P46100	ATRX_HUMAN	transcriptional regulator ATRX isoform 1	447					DNA methylation|DNA recombination|DNA repair|regulation of transcription, DNA-dependent	nuclear heterochromatin	ATP binding|chromo shadow domain binding|DNA binding|DNA helicase activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(14)|pancreas(12)|lung(1)|breast(1)|skin(1)|kidney(1)	30					Phosphatidylserine(DB00144)	CAAGGTTTTTCTCCTTTTCGT	0.363		NA	Mis|F|N		Pancreatic neuroendocrine tumors		ATR-X (alpha thalassemia/mental retardation) syndrome						60	379					0	0	0	0
PGAM4	441531	broad.mit.edu	37	X	77224509	77224509	+	Silent	SNP	G	G	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chrX:77224509G>A	uc004ecy.1	-	1	627	c.627C>T	c.(625-627)AAC>AAT	p.N209N	ATP7A_uc004ecw.2_Intron|ATP7A_uc004ecx.3_Intron	NM_001029891	NP_001025062	Q8N0Y7	PGAM4_HUMAN	bisphosphoglycerate mutase 4	209					glycolysis		2,3-bisphospho-D-glycerate 2-phosphohydrolase activity|bisphosphoglycerate mutase activity|phosphoglycerate mutase activity				0						CAGTCGGCAGGTTCAGCTCCA	0.527		NA											11	232					0	0	0	0
GPRASP1	9737	broad.mit.edu	37	X	101909693	101909693	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chrX:101909693G>T	uc004ejj.3	+	5	1653	c.852G>T	c.(850-852)AGG>AGT	p.R284S	GPRASP1_uc004eji.3_Missense_Mutation_p.R284S|GPRASP1_uc010nod.2_Missense_Mutation_p.R284S	NM_014710	NP_055525	Q5JY77	GASP1_HUMAN	G protein-coupled receptor associated sorting	284						cytoplasm	protein binding			ovary(1)|lung(1)	2						GCAGGTCCAGGTTTAGGTCTA	0.483		NA											19	241					1.56e-12	1.8e-12	1	0
RAB40A	142684	broad.mit.edu	37	X	102755663	102755663	+	Missense_Mutation	SNP	C	C	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chrX:102755663C>A	uc004ekk.2	-	3	364	c.22G>T	c.(22-24)GAC>TAC	p.D8Y		NM_080879	NP_543155	Q8WXH6	RB40A_HUMAN	RAB40A, member RAS oncogene family	8					protein transport|small GTPase mediated signal transduction	plasma membrane	GTP binding				0						TAGGCCTGGTCGGGGCTGCCC	0.667		NA											12	81					5.17e-11	5.88e-11	1	0
WDR44	54521	broad.mit.edu	37	X	117582909	117582909	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chrX:117582909G>A	uc004eqn.2	+	20	3126	c.2701G>A	c.(2701-2703)GCA>ACA	p.A901T	WDR44_uc004eqo.2_Missense_Mutation_p.A893T|WDR44_uc011mtr.1_Missense_Mutation_p.A812T|WDR44_uc010nqi.2_3'UTR	NM_019045	NP_061918	Q5JSH3	WDR44_HUMAN	WD repeat domain 44 protein	901	WD 7.					cytosol|endosome membrane|Golgi apparatus|perinuclear region of cytoplasm				lung(2)|upper_aerodigestive_tract(1)|ovary(1)|pancreas(1)	5						CTTCACTGGAGCAATCAAAGT	0.254		NA											16	91					0	0	0	0
CT47B1	643311	broad.mit.edu	37	X	120008795	120008795	+	Missense_Mutation	SNP	G	G	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chrX:120008795G>A	uc011muc.1	-	1	985	c.730C>T	c.(730-732)CCG>TCG	p.P244S		NM_001145718	NP_001139190	P0C2W7	CT47B_HUMAN	cancer/testis antigen family 147, member B1	244											0						TCTGCGGCCGGTtcctctgtg	0.547		NA											34	197					0	0	0	0
PNMA5	114824	broad.mit.edu	37	X	152159412	152159412	+	Missense_Mutation	SNP	G	G	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chrX:152159412G>T	uc010ntw.2	-	3	1070	c.731C>A	c.(730-732)TCT>TAT	p.S244Y	PNMA5_uc004fha.3_Missense_Mutation_p.S244Y|PNMA5_uc010ntx.2_Missense_Mutation_p.S244Y|PNMA5_uc004fgy.3_Missense_Mutation_p.S244Y	NM_001103151	NP_001096621	Q96PV4	PNMA5_HUMAN	paraneoplastic antigen like 5	244					apoptosis					ovary(1)|skin(1)	2	Acute lymphoblastic leukemia(192;6.56e-05)					CCTAAACTGAGAGGCTCTAAA	0.522		NA											30	184					3e-07	3.34e-07	1	0
PNMA3	29944	broad.mit.edu	37	X	152226640	152226640	+	Missense_Mutation	SNP	C	C	T			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chrX:152226640C>T	uc004fhc.2	+	2	1564	c.1228C>T	c.(1228-1230)CGC>TGC	p.R410C	PNMA5_uc004fha.3_5'Flank|PNMA3_uc004fhd.2_5'Flank	NM_013364	NP_037496	Q9UL41	PNMA3_HUMAN	paraneoplastic cancer-testis-brain antigen	410	Arg-rich.				apoptosis	nucleolus	nucleic acid binding|zinc ion binding			skin(2)|large_intestine(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					AAAACGGAAACGCCACACATT	0.597		NA											16	137					0	0	0	0
MYCBP2	23077	broad.mit.edu	37	13	77625189	77625190	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr13:77625189_77625190insA	uc001vkf.2	-	83	13840_13841	c.13749_13750insT	c.(13747-13752)CATGATfs	p.H4583fs	MYCBP2_uc010aev.2_Frame_Shift_Ins_p.H3987fs|MYCBP2_uc001vke.2_Frame_Shift_Ins_p.H1200fs	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	4583_4584	B box-type.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		TGAAAATCATCATGACAAGCAT	0.347		NA											23	138	---	---	---	---	NA	NA	NA	NA
JUB	84962	broad.mit.edu	37	14	23450566	23450567	+	Frame_Shift_Ins	INS	-	-	C			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr14:23450566_23450567insC	uc001whz.2	-	1	1285_1286	c.909_910insG	c.(907-912)GGGATTfs	p.G303fs		NM_032876	NP_116265	Q96IF1	JUB_HUMAN	ajuba isoform 1	303_304	PreLIM.				cell cycle|gene silencing by miRNA|positive regulation of protein complex assembly	cell-cell junction|cytoplasmic mRNA processing body|microtubule organizing center	alpha-catenin binding|zinc ion binding				0	all_cancers(95;4.6e-05)			GBM - Glioblastoma multiforme(265;0.0122)		GACGGCTCAATCCCCGAGGGTT	0.703		NA											9	49	---	---	---	---	NA	NA	NA	NA
TP53BP1	7158	broad.mit.edu	37	15	43701208	43701209	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr15:43701208_43701209insG	uc001zrs.2	-	26	5619_5620	c.5471_5472insC	c.(5470-5472)CCTfs	p.P1824fs	TP53BP1_uc010udp.1_Frame_Shift_Ins_p.P1822fs|TP53BP1_uc001zrq.3_Frame_Shift_Ins_p.P1827fs|TP53BP1_uc001zrr.3_Frame_Shift_Ins_p.P1829fs|TP53BP1_uc001zrp.2_Frame_Shift_Ins_p.P241fs	NM_005657	NP_005648	Q12888	TP53B_HUMAN	tumor protein p53 binding protein 1 isoform 3	1824	BRCT 1.				double-strand break repair via homologous recombination|positive regulation of transcription from RNA polymerase II promoter	condensed chromosome kinetochore|cytoplasm|nucleoplasm	p53 binding|RNA polymerase II activating transcription factor binding|RNA polymerase II transcription cofactor activity			ovary(2)|skin(2)|large_intestine(1)|pancreas(1)|kidney(1)	7		all_cancers(109;6.94e-11)|all_epithelial(112;2.69e-09)|Lung NSC(122;7.86e-07)|all_lung(180;7.84e-06)|Melanoma(134;0.0728)		GBM - Glioblastoma multiforme(94;1.59e-06)		GAGACACACAAGGAATCCCACT	0.49		NA						Direct_reversal_of_damage|Other_conserved_DNA_damage_response_genes					16	123	---	---	---	---	NA	NA	NA	NA
WWP1	11059	broad.mit.edu	37	8	87470164	87470165	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BA-5556-01A-01D-1512-08	TCGA-BA-5556-10A-01D-1512-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	d31fda32-363b-44e4-8f2c-834a66f46b87	39b1a5f5-ffcd-4af3-8a6f-3c71f1496df7	g.chr8:87470164_87470165insA	uc003ydt.2	+	22	2689_2690	c.2409_2410insA	c.(2407-2412)GGCATGfs	p.G803fs		NM_007013	NP_008944	Q9H0M0	WWP1_HUMAN	WW domain containing E3 ubiquitin protein ligase	803_804	HECT.			M->P: Strongly reduces ubiquitin transfer; when associated with P-806.	central nervous system development|entry of virus into host cell|negative regulation of transcription, DNA-dependent|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|signal transduction	cytoplasm|nucleus|plasma membrane|ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			lung(1)|liver(1)	2						TGTTGTGTGGCATGCAGGAGGT	0.376		NA											32	194	---	---	---	---	NA	NA	NA	NA
