Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
ECE1	1889	broad.mit.edu	37	1	21599368	21599368	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:21599368G>A	uc001bek.2	-	4	392	c.317C>T	c.(316-318)TCA>TTA	p.S106L	ECE1_uc001bem.2_Missense_Mutation_p.S90L|ECE1_uc001bej.2_Missense_Mutation_p.S94L|ECE1_uc001bei.2_Missense_Mutation_p.S103L|ECE1_uc010odl.1_Missense_Mutation_p.S106L|ECE1_uc009vqa.1_Missense_Mutation_p.S106L	NM_001397	NP_001388	P42892	ECE1_HUMAN	endothelin converting enzyme 1 isoform 1	106	Extracellular (Potential).				bradykinin catabolic process|calcitonin catabolic process|ear development|embryonic digit morphogenesis|endothelin maturation|heart development|positive regulation of receptor recycling|substance P catabolic process	early endosome|external side of plasma membrane|integral to membrane|intrinsic to endosome membrane|membrane fraction|perinuclear region of cytoplasm|plasma membrane|Weibel-Palade body	metal ion binding|metalloendopeptidase activity|protein homodimerization activity			ovary(2)|skin(1)	3		Lung NSC(340;1.14e-05)|all_lung(284;1.23e-05)|Colorectal(325;3.46e-05)|Renal(390;9.67e-05)|Breast(348;0.00147)|Ovarian(437;0.00432)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0183)|OV - Ovarian serous cystadenocarcinoma(117;4.83e-27)|COAD - Colon adenocarcinoma(152;1.36e-06)|GBM - Glioblastoma multiforme(114;1.47e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000162)|STAD - Stomach adenocarcinoma(196;0.00326)|KIRC - Kidney renal clear cell carcinoma(1967;0.00755)|READ - Rectum adenocarcinoma(331;0.0678)|Lung(427;0.206)		GCTGGTCACTGAGACACAAGC	0.597		NA											10	80					0	0	0	0
MECR	51102	broad.mit.edu	37	1	29557401	29557401	+	Silent	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:29557401G>A	uc001brq.1	-	1	54	c.18C>T	c.(16-18)ACC>ACT	p.T6T	MECR_uc001brp.1_5'UTR|MECR_uc001brr.1_5'UTR|MECR_uc001brs.1_RNA|MECR_uc001brt.1_5'UTR|MECR_uc010ofz.1_Silent_p.T6T	NM_016011	NP_057095	Q9BV79	MECR_HUMAN	trans-2-enoyl-CoA reductase, mitochondrial	6					fatty acid biosynthetic process	mitochondrion	trans-2-enoyl-CoA reductase (NADPH) activity|zinc ion binding			ovary(1)	1		Colorectal(325;0.000389)|Breast(348;0.00765)|Lung NSC(340;0.0081)|all_lung(284;0.00914)|all_neural(195;0.0199)|Ovarian(437;0.0228)|Myeloproliferative disorder(586;0.0255)|Medulloblastoma(700;0.123)		Colorectal(126;3.39e-07)|COAD - Colon adenocarcinoma(152;2.04e-05)|STAD - Stomach adenocarcinoma(196;0.0195)|BRCA - Breast invasive adenocarcinoma(304;0.053)|READ - Rectum adenocarcinoma(331;0.0649)|KIRC - Kidney renal clear cell carcinoma(1967;0.137)		CCCGCCACAGGGTACTGCAGA	0.721		NA											3	27					0	0	0	0
ZMYM4	9202	broad.mit.edu	37	1	35859302	35859302	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:35859302C>T	uc001byt.2	+	18	2953	c.2873C>T	c.(2872-2874)TCT>TTT	p.S958F	ZMYM4_uc009vuu.2_Missense_Mutation_p.S926F|ZMYM4_uc001byu.2_Missense_Mutation_p.S634F|ZMYM4_uc009vuv.2_Missense_Mutation_p.S697F	NM_005095	NP_005086	Q5VZL5	ZMYM4_HUMAN	zinc finger protein 262	958					multicellular organismal development		DNA binding|zinc ion binding			large_intestine(2)|ovary(1)|kidney(1)|skin(1)	5		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AAAGCCACCTCTTGCAAACCA	0.398		NA											11	88					0	0	0	0
EBNA1BP2	10969	broad.mit.edu	37	1	43637162	43637162	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:43637162C>T	uc001cin.2	-	3	508	c.311G>A	c.(310-312)CGA>CAA	p.R104Q	EBNA1BP2_uc001cio.2_Missense_Mutation_p.R159Q|WDR65_uc010ojz.1_5'Flank|WDR65_uc001cip.1_5'Flank|WDR65_uc001ciq.1_5'Flank|EBNA1BP2_uc001cim.2_5'UTR|EBNA1BP2_uc010ojx.1_Missense_Mutation_p.R159Q	NM_006824	NP_006815	Q99848	EBP2_HUMAN	EBNA1 binding protein 2 isoform 2	104					ribosome biogenesis	membrane fraction|nucleolus	protein binding				0	Ovarian(52;0.00579)|all_hematologic(146;0.0977)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				ACTCATCTCTCGCTGGAAGTC	0.493		NA											15	126					0	0	0	0
UROD	7389	broad.mit.edu	37	1	45478996	45478996	+	Silent	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:45478996C>T	uc001cna.1	+	4	354	c.246C>T	c.(244-246)ATC>ATT	p.I82I	HECTD3_uc009vxk.2_5'Flank|HECTD3_uc010olh.1_5'Flank|UROD_uc010oli.1_Missense_Mutation_p.H108Y|UROD_uc001cnb.1_Silent_p.I47I|UROD_uc010olj.1_Intron|UROD_uc001cnc.1_5'UTR	NM_000374	NP_000365	P06132	DCUP_HUMAN	uroporphyrinogen decarboxylase	82						cytosol|microtubule cytoskeleton|nucleus	uroporphyrinogen decarboxylase activity				0	Acute lymphoblastic leukemia(166;0.155)					ATGCTGCCATCATTTTCTCCG	0.483		NA							Porphyria_Cutanea_Tarda_Type_II				37	130					0	0	0	0
KTI12	112970	broad.mit.edu	37	1	52499004	52499004	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:52499004C>T	uc001ctj.1	-	1	469	c.430G>A	c.(430-432)GCC>ACC	p.A144T	TXNDC12_uc001cti.2_Intron	NM_138417	NP_612426	Q96EK9	KTI12_HUMAN	KTI12 homolog, chromatin associated	144							ATP binding			central_nervous_system(2)	2						GCCGCCTGGGCTCTCCCGTCC	0.672		NA											21	72					0	0	0	0
CLCA4	22802	broad.mit.edu	37	1	87012825	87012825	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:87012825T>C	uc009wcs.2	+	1	67	c.23T>C	c.(22-24)GTT>GCT	p.V8A	CLCA4_uc009wct.2_5'UTR|CLCA4_uc009wcu.2_5'UTR	NM_012128	NP_036260	Q14CN2	CLCA4_HUMAN	chloride channel accessory 4	8						apical plasma membrane|extracellular region|integral to plasma membrane	chloride channel activity			ovary(2)	2		Lung NSC(277;0.238)		all cancers(265;0.0202)|Epithelial(280;0.0404)		AGAGGTTTTGTTTTCCTCTTA	0.363		NA											11	98					0	0	0	0
CCDC76	54482	broad.mit.edu	37	1	100606565	100606565	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:100606565C>T	uc001dsv.2	+	7	678	c.659C>T	c.(658-660)ACA>ATA	p.T220I	CCDC76_uc010ouf.1_RNA|CCDC76_uc009wea.2_Missense_Mutation_p.T220I	NM_019083	NP_061956	Q9NUP7	TRM13_HUMAN	coiled-coil domain containing 76	220					tRNA processing		metal ion binding|methyltransferase activity			ovary(1)	1		all_epithelial(167;0.000542)|all_lung(203;0.0154)|Lung NSC(277;0.0155)		Epithelial(280;0.0814)|all cancers(265;0.133)|COAD - Colon adenocarcinoma(174;0.146)|Lung(183;0.194)		AAGGTGACCACAAGATTCAAG	0.348		NA											6	41					0	0	0	0
AKNAD1	254268	broad.mit.edu	37	1	109366241	109366241	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:109366241C>T	uc001dwa.2	-	12	2275	c.2006G>A	c.(2005-2007)TGT>TAT	p.C669Y	AKNAD1_uc010ovb.1_Missense_Mutation_p.C376Y|AKNAD1_uc001dwb.2_RNA	NM_152763	NP_689976	Q5T1N1	AKND1_HUMAN	hypothetical protein LOC254268	669										ovary(3)	3						CTTAGTGCCACAGTCCTGACA	0.488		NA											10	55					0	0	0	0
DENND2D	79961	broad.mit.edu	37	1	111731345	111731345	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:111731345G>A	uc001eak.1	-	10	1278	c.1078C>T	c.(1078-1080)CAG>TAG	p.Q360*	DENND2D_uc001eal.1_Nonsense_Mutation_p.Q357*	NM_024901	NP_079177	Q9H6A0	DEN2D_HUMAN	DENN/MADD domain containing 2D	360										ovary(1)	1		all_cancers(81;0.00198)|all_epithelial(167;0.000686)|all_lung(203;0.00318)|Lung NSC(277;0.00499)		Lung(183;0.0162)|Colorectal(144;0.069)|all cancers(265;0.0757)|LUSC - Lung squamous cell carcinoma(189;0.0845)|Epithelial(280;0.114)|COAD - Colon adenocarcinoma(174;0.14)		TTGATCCCCTGACCAAGAGAG	0.468		NA											8	207					0	0	0	0
HRNR	388697	broad.mit.edu	37	1	152187050	152187050	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:152187050G>A	uc001ezt.1	-	3	7131	c.7055C>T	c.(7054-7056)TCT>TTT	p.S2352F		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2352	25				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGTGTAACCAGAGGACTGCCA	0.567		NA											19	301					0	0	0	0
PPP1R12B	4660	broad.mit.edu	37	1	202464747	202464747	+	Silent	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:202464747C>T	uc001gya.1	+	17	2529	c.2385C>T	c.(2383-2385)ATC>ATT	p.I795I	PPP1R12B_uc001gxz.1_Silent_p.I795I|PPP1R12B_uc001gyb.1_Silent_p.I21I|PPP1R12B_uc001gyc.1_Silent_p.I21I	NM_002481	NP_002472	O60237	MYPT2_HUMAN	protein phosphatase 1, regulatory (inhibitor)	795					regulation of muscle contraction|signal transduction	cytoplasm	enzyme activator activity			ovary(3)	3			BRCA - Breast invasive adenocarcinoma(75;0.166)			GGCTGTCCATCCGAGAGAGGA	0.463		NA											7	48					0	0	0	0
USH2A	7399	broad.mit.edu	37	1	216017746	216017746	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:216017746C>T	uc001hku.1	-	46	9535	c.9148G>A	c.(9148-9150)GTC>ATC	p.V3050I		NM_206933	NP_996816	O75445	USH2A_HUMAN	usherin isoform B	3050	Fibronectin type-III 17.|Extracellular (Potential).				maintenance of organ identity|photoreceptor cell maintenance|response to stimulus|sensory perception of sound	basement membrane|cytoplasm|integral to membrane|stereocilium membrane	collagen binding			ovary(20)|upper_aerodigestive_tract(2)|skin(2)|kidney(1)|central_nervous_system(1)	26				OV - Ovarian serous cystadenocarcinoma(81;0.0547)|all cancers(67;0.0875)		TACTCAGTGACAACACCATTT	0.433		NA								HNSCC(13;0.011)			7	61					0	0	0	0
MIA3	375056	broad.mit.edu	37	1	222801790	222801790	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:222801790G>A	uc001hnl.2	+	4	1237	c.1228G>A	c.(1228-1230)GAA>AAA	p.E410K	MIA3_uc009xea.1_Missense_Mutation_p.E246K	NM_198551	NP_940953	Q5JRA6	MIA3_HUMAN	melanoma inhibitory activity family, member 3	410	Extracellular (Potential).				exocytosis|negative regulation of cell adhesion|negative regulation of cell migration|positive regulation of leukocyte migration|protein transport|wound healing	endoplasmic reticulum membrane|integral to membrane	protein binding			ovary(4)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(131;0.0199)		TAGTTCAGAGGAAGAAAAAGA	0.408		NA											15	61					0	0	0	0
LYST	1130	broad.mit.edu	37	1	235904814	235904814	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:235904814G>A	uc001hxj.2	-	31	8441	c.8266C>T	c.(8266-8268)CAC>TAC	p.H2756Y	LYST_uc009xga.1_Missense_Mutation_p.H392Y	NM_000081	NP_000072	Q99698	LYST_HUMAN	lysosomal trafficking regulator	2756					defense response to bacterium|defense response to protozoan|defense response to virus|endosome to lysosome transport via multivesicular body sorting pathway|leukocyte chemotaxis|mast cell secretory granule organization|melanosome organization|natural killer cell mediated cytotoxicity|protein transport	cytoplasm|microtubule cytoskeleton	protein binding			ovary(6)|breast(4)|central_nervous_system(2)	12	Ovarian(103;0.0634)|Breast(184;0.23)	all_cancers(173;0.00246)|Prostate(94;0.0771)|Acute lymphoblastic leukemia(190;0.228)	OV - Ovarian serous cystadenocarcinoma(106;0.000674)			TGTGCAGCGTGGGCTGGCGAC	0.438		NA							Chediak-Higashi_syndrome				11	77					0	0	0	0
OR2L8	391190	broad.mit.edu	37	1	248112567	248112567	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:248112567C>A	uc001idt.1	+	1	408	c.408C>A	c.(406-408)AGC>AGA	p.S136R	OR2L13_uc001ids.2_Intron	NM_001001963	NP_001001963	Q8NGY9	OR2L8_HUMAN	olfactory receptor, family 2, subfamily L,	136	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(71;0.000139)|all_epithelial(71;1.58e-05)|Breast(184;0.0117)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0152)			TCCGCATGAGCAAAAGAGTGT	0.438		NA											5	239					0.000602214	0.000633634	1	0
OR2T6	254879	broad.mit.edu	37	1	248551586	248551586	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:248551586A>C	uc001iei.1	+	1	677	c.677A>C	c.(676-678)CAT>CCT	p.H226P		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	226	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			ATCACAGTGCATCAGATGACA	0.502		NA											24	85					0	0	0	0
OR2T11	127077	broad.mit.edu	37	1	248790265	248790265	+	Silent	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr1:248790265G>A	uc001ier.1	-	1	165	c.165C>T	c.(163-165)CCC>CCT	p.P55P		NM_001001964	NP_001001964	Q8NH01	O2T11_HUMAN	olfactory receptor, family 2, subfamily T,	55	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			GAAAGTACATGGGGGTGTGGA	0.468		NA											6	69					0	0	0	0
KIAA1462	57608	broad.mit.edu	37	10	30316179	30316179	+	Silent	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr10:30316179G>A	uc001iux.2	-	2	2957	c.2898C>T	c.(2896-2898)GAC>GAT	p.D966D	KIAA1462_uc001iuy.2_Intron|KIAA1462_uc001iuz.2_Silent_p.D828D|KIAA1462_uc009xle.1_Silent_p.D966D	NM_020848	NP_065899	Q9P266	K1462_HUMAN	hypothetical protein LOC57608	966										ovary(4)	4						CTGCCAGCTCGTCCATTCCGT	0.567		NA											20	59					0	0	0	0
FAM13C	220965	broad.mit.edu	37	10	61022290	61022290	+	Silent	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr10:61022290G>A	uc001jkn.2	-	11	1274	c.1140C>T	c.(1138-1140)GGC>GGT	p.G380G	FAM13C_uc001jko.2_Intron|FAM13C_uc010qid.1_Silent_p.G297G|FAM13C_uc010qie.1_Silent_p.G297G|FAM13C_uc010qif.1_Silent_p.G402G|FAM13C_uc001jkp.2_Silent_p.G297G	NM_198215	NP_937858	Q8NE31	FA13C_HUMAN	hypothetical protein LOC220965 isoform 1	380										ovary(2)	2						TTGGCTCCGGGCCCGCAGCTT	0.547		NA											7	64					0	0	0	0
ANKRD2	26287	broad.mit.edu	37	10	99340627	99340627	+	Silent	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr10:99340627C>T	uc001knw.2	+	5	762	c.553C>T	c.(553-555)CTG>TTG	p.L185L	ANKRD2_uc009xvu.2_Silent_p.L185L	NM_020349	NP_065082	Q9GZV1	ANKR2_HUMAN	ankyrin repeat domain 2 isoform a	185	ANK 2.				muscle contraction|muscle organ development		structural constituent of muscle				0		all_hematologic(284;1.95e-06)|Colorectal(252;0.0163)		Epithelial(162;1.18e-94)|all cancers(201;9.31e-86)|BRCA - Breast invasive adenocarcinoma(275;0.0233)|STAD - Stomach adenocarcinoma(243;0.181)|KIRC - Kidney renal clear cell carcinoma(50;0.206)|Kidney(138;0.241)		TCGGACAGCACTGCACCGAGC	0.627		NA											3	9					0	0	0	0
GOT1	2805	broad.mit.edu	37	10	101190305	101190305	+	Silent	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr10:101190305G>A	uc001kpr.2	-	1	226	c.18C>T	c.(16-18)GTC>GTT	p.V6V	GOT1_uc009xwh.2_RNA|GOT1_uc009xwi.2_Silent_p.V6V	NM_002079	NP_002070	P17174	AATC_HUMAN	aspartate aminotransferase 1	6					aspartate catabolic process|cellular response to insulin stimulus|gluconeogenesis|response to glucocorticoid stimulus	cytosol	L-aspartate:2-oxoglutarate aminotransferase activity|pyridoxal phosphate binding				0		Ovarian(717;0.028)|Colorectal(252;0.234)		Epithelial(162;4.76e-10)|all cancers(201;3.84e-08)	L-Aspartic Acid(DB00128)|L-Cysteine(DB00151)|L-Glutamic Acid(DB00142)|Pyridoxal Phosphate(DB00114)	CCTCGGCAAAGACTGACGGAG	0.617		NA											13	93					0	0	0	0
SORCS3	22986	broad.mit.edu	37	10	106899161	106899161	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr10:106899161A>C	uc001kyi.1	+	8	1446	c.1219A>C	c.(1219-1221)ACT>CCT	p.T407P		NM_014978	NP_055793	Q9UPU3	SORC3_HUMAN	VPS10 domain receptor protein SORCS 3 precursor	407	Lumenal (Potential).					integral to membrane	neuropeptide receptor activity			ovary(6)|skin(3)|central_nervous_system(1)	10		Colorectal(252;0.134)|Breast(234;0.142)|Lung NSC(174;0.191)		Epithelial(162;1.58e-07)|all cancers(201;1.02e-05)|BRCA - Breast invasive adenocarcinoma(275;0.0628)		CTAGGTAACAACTAGTGGAAG	0.458		NA											10	91					0	0	0	0
WDR11	55717	broad.mit.edu	37	10	122668114	122668114	+	Silent	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr10:122668114G>A	uc010qtf.1	+	29	3802	c.3564G>A	c.(3562-3564)AAG>AAA	p.K1188K	WDR11_uc009xzn.2_3'UTR	NM_018117	NP_060587	Q9BZH6	WDR11_HUMAN	bromodomain and WD repeat domain containing 2	1188						integral to membrane					0						GGAGTTTGAAGAACCTCGGTT	0.438		NA											5	89					0	0	0	0
ART1	417	broad.mit.edu	37	11	3681285	3681285	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr11:3681285G>T	uc001lye.1	+	3	637	c.536G>T	c.(535-537)CGA>CTA	p.R179L	ART1_uc009yeb.1_Missense_Mutation_p.R179L	NM_004314	NP_004305	P52961	NAR1_HUMAN	ADP-ribosyltransferase 1 precursor	179		NAD (By similarity).			protein ADP-ribosylation	anchored to membrane|integral to plasma membrane|sarcoplasmic reticulum membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity				0		Medulloblastoma(188;0.0025)|Breast(177;0.00328)|all_neural(188;0.0227)		BRCA - Breast invasive adenocarcinoma(625;0.0351)|LUSC - Lung squamous cell carcinoma(625;0.195)	Becaplermin(DB00102)	CAGGTGTTCCGAGGTGTGCAC	0.672		NA											14	18					4.38e-07	4.75e-07	1	0
MS4A4A	51338	broad.mit.edu	37	11	60059779	60059779	+	Silent	SNP	A	A	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr11:60059779A>T	uc001noz.2	+	2	133	c.123A>T	c.(121-123)GGA>GGT	p.G41G	MS4A4A_uc001npa.2_Silent_p.G22G|MS4A4A_uc001npb.2_Silent_p.G22G|MS4A4A_uc001npc.2_Silent_p.G22G	NM_148975	NP_683876	Q96JQ5	M4A4A_HUMAN	membrane-spanning 4-domains, subfamily A, member	41	Cytoplasmic (Potential).					integral to membrane	receptor activity				0						CCCAGCTGGGAAACATGGCTG	0.488		NA											12	64					0	0	0	0
AHNAK	79026	broad.mit.edu	37	11	62294494	62294494	+	Silent	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr11:62294494G>A	uc001ntl.2	-	5	7695	c.7395C>T	c.(7393-7395)CCC>CCT	p.P2465P	AHNAK_uc001ntk.1_Intron	NM_001620	NP_001611	Q09666	AHNK_HUMAN	AHNAK nucleoprotein isoform 1	2465					nervous system development	nucleus	protein binding			ovary(10)|pancreas(4)|skin(4)|upper_aerodigestive_tract(1)	19		Melanoma(852;0.155)				CCTTGATTTTGGGTCCTTTGA	0.443		NA											23	216					0	0	0	0
ADRBK1	156	broad.mit.edu	37	11	67052618	67052618	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr11:67052618C>T	uc009yrn.1	+	20	2130	c.1864C>T	c.(1864-1866)CTC>TTC	p.L622F	ADRBK1_uc009yrm.1_Intron	NM_001619	NP_001610	P25098	ARBK1_HUMAN	beta-adrenergic receptor kinase 1	622	PH.				activation of phospholipase C activity|cardiac muscle contraction|desensitization of G-protein coupled receptor protein signaling pathway|muscarinic acetylcholine receptor signaling pathway|negative regulation of striated muscle contraction|negative regulation of the force of heart contraction by chemical signal|nerve growth factor receptor signaling pathway|peptidyl-serine phosphorylation|positive regulation of catecholamine secretion|tachykinin receptor signaling pathway	cytosol|soluble fraction	alpha-2A adrenergic receptor binding|ATP binding|beta-adrenergic receptor kinase activity|Edg-2 lysophosphatidic acid receptor binding|G-protein coupled receptor kinase activity|signal transducer activity			large_intestine(1)	1			BRCA - Breast invasive adenocarcinoma(15;2.26e-06)		Adenosine triphosphate(DB00171)	GTGCCTGCTCCTCAAGATCCG	0.647		NA											21	303					0	0	0	0
SHANK2	22941	broad.mit.edu	37	11	70332040	70332040	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr11:70332040G>A	uc001oqc.2	-	21	4436	c.4358C>T	c.(4357-4359)TCC>TTC	p.S1453F	SHANK2_uc010rqn.1_Missense_Mutation_p.S865F|SHANK2_uc001opz.2_Missense_Mutation_p.S858F|uc009ysn.1_Intron|SHANK2_uc001opy.2_Intron	NM_012309	NP_036441	Q9UPX8	SHAN2_HUMAN	SH3 and multiple ankyrin repeat domains 2	1074					intracellular signal transduction	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane	GKAP/Homer scaffold activity|ionotropic glutamate receptor binding|SH3 domain binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5			LUSC - Lung squamous cell carcinoma(11;4.72e-09)|STAD - Stomach adenocarcinoma(18;0.071)			TGGTTGGCTGGAGTTCAACGA	0.547		NA											8	297					0	0	0	0
KRTAP5-10	387273	broad.mit.edu	37	11	71276860	71276860	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr11:71276860C>G	uc001oqt.1	+	1	252	c.227C>G	c.(226-228)TCT>TGT	p.S76C		NM_001012710	NP_001012728	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	76	7 X 4 AA repeats of C-C-X-P.					keratin filament				skin(1)	1						GACTGTGGCTCTTGTGGGGGC	0.677		NA											94	273					0	0	0	0
KRTAP5-10	387273	broad.mit.edu	37	11	71277239	71277239	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr11:71277239C>G	uc001oqt.1	+	1	631	c.606C>G	c.(604-606)ATC>ATG	p.I202M		NM_001012710	NP_001012728	Q6L8G5	KR510_HUMAN	keratin associated protein 5-10	202						keratin filament				skin(1)	1						AGTGTAAGATCTGAGGCTCTG	0.313		NA											86	136					0	0	0	0
FAT3	120114	broad.mit.edu	37	11	92624271	92624271	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr11:92624271C>T	uc001pdj.3	+	25	13683	c.13666C>T	c.(13666-13668)CAA>TAA	p.Q4556*	FAT3_uc001pdi.3_Nonsense_Mutation_p.Q1028*	NM_001008781	NP_001008781	Q8TDW7	FAT3_HUMAN	FAT tumor suppressor homolog 3	4588	Cytoplasmic (Potential).				homophilic cell adhesion|multicellular organismal development	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|pancreas(1)	5		Acute lymphoblastic leukemia(157;3.01e-05)|all_hematologic(158;0.00858)				GCATCAGACTCAAGTGTAGAC	0.507		NA								TCGA Ovarian(4;0.039)			11	16					0	0	0	0
ZC3H12C	85463	broad.mit.edu	37	11	110036199	110036199	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr11:110036199G>A	uc009yxw.2	+	6	2440	c.2389G>A	c.(2389-2391)GAT>AAT	p.D797N	ZC3H12C_uc010rwc.1_Missense_Mutation_p.D798N|ZC3H12C_uc010rwd.1_Missense_Mutation_p.D798N|ZC3H12C_uc001pkr.3_Missense_Mutation_p.D766N	NM_033390	NP_203748	Q9C0D7	ZC12C_HUMAN	zinc finger CCCH-type containing 12C	797							endonuclease activity|nucleic acid binding|zinc ion binding				0		all_cancers(61;3.24e-13)|all_epithelial(67;1.27e-07)|Melanoma(852;1.46e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;3.95e-05)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)|Breast(348;0.0544)		Epithelial(105;1.72e-06)|BRCA - Breast invasive adenocarcinoma(274;1.17e-05)|all cancers(92;9e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0279)		TTCCTTGCCCGATAACTCCAC	0.572		NA											3	40					0	0	0	0
NTM	50863	broad.mit.edu	37	11	132081943	132081943	+	Nonsense_Mutation	SNP	C	C	G			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr11:132081943C>G	uc001qgp.2	+	3	1092	c.428C>G	c.(427-429)TCA>TGA	p.S143*	NTM_uc001qgm.2_Nonsense_Mutation_p.S143*|NTM_uc010sch.1_Nonsense_Mutation_p.S134*|NTM_uc010sci.1_Nonsense_Mutation_p.S143*|NTM_uc010scj.1_Nonsense_Mutation_p.S102*|NTM_uc001qgo.2_Nonsense_Mutation_p.S143*|NTM_uc001qgq.2_Nonsense_Mutation_p.S143*|NTM_uc001qgr.2_5'UTR	NM_016522	NP_057606	Q9P121	NTRI_HUMAN	neurotrimin isoform 1	143	Ig-like C2-type 2.				cell adhesion|neuron recognition	anchored to membrane|plasma membrane				ovary(4)|central_nervous_system(1)|skin(1)	6						GAGATTTCTTCAGATATCTCC	0.393		NA											7	59					0	0	0	0
WBP11	51729	broad.mit.edu	37	12	14949890	14949890	+	Missense_Mutation	SNP	C	C	G			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr12:14949890C>G	uc001rci.2	-	5	399	c.238G>C	c.(238-240)GAC>CAC	p.D80H		NM_016312	NP_057396	Q9Y2W2	WBP11_HUMAN	WW domain binding protein 11	80	Potential.				mRNA processing|RNA splicing|rRNA processing	cytoplasm	single-stranded DNA binding|WW domain binding			ovary(1)|lung(1)	2						TTACGCTTGTCTTTCAGTACT	0.343		NA											27	36					0	0	0	0
PDE3A	5139	broad.mit.edu	37	12	20799470	20799470	+	Silent	SNP	T	T	C			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr12:20799470T>C	uc001reh.1	+	11	2320	c.2298T>C	c.(2296-2298)TAT>TAC	p.Y766Y		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	766	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	CTGTTTGGTATCTTACTACAC	0.413		NA											12	51					0	0	0	0
YARS2	51067	broad.mit.edu	37	12	32900172	32900172	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr12:32900172C>T	uc001rli.2	-	5	1466	c.1400G>A	c.(1399-1401)AGA>AAA	p.R467K		NM_001040436	NP_001035526	Q9Y2Z4	SYYM_HUMAN	tyrosyl-tRNA synthetase 2, mitochondrial	467					tyrosyl-tRNA aminoacylation	mitochondrial matrix	ATP binding|protein binding|RNA binding|tyrosine-tRNA ligase activity				0	Lung NSC(5;2.43e-07)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.0429)|Esophageal squamous(101;0.239)				L-Tyrosine(DB00135)	GTAGAAATTTCTTTTTCCTAT	0.338		NA											19	30					0	0	0	0
KIF21A	55605	broad.mit.edu	37	12	39726145	39726145	+	Silent	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr12:39726145C>T	uc001rly.2	-	21	3068	c.2922G>A	c.(2920-2922)GAG>GAA	p.E974E	KIF21A_uc001rlv.2_5'UTR|KIF21A_uc001rlw.2_Silent_p.E291E|KIF21A_uc001rlx.2_Silent_p.E961E|KIF21A_uc001rlz.2_Silent_p.E938E|KIF21A_uc010skl.1_Silent_p.E961E	NM_017641	NP_060111	Q7Z4S6	KI21A_HUMAN	kinesin family member 21A	974	Potential.				microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(4)|pancreas(1)|lung(1)|skin(1)	7		Lung NSC(34;0.179)|all_lung(34;0.213)				CCTCTCCATTCTCCTTGACTA	0.373		NA											12	149					0	0	0	0
LRRK2	120892	broad.mit.edu	37	12	40651163	40651163	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr12:40651163C>T	uc001rmg.3	+	12	1523	c.1402C>T	c.(1402-1404)CAT>TAT	p.H468Y	LRRK2_uc001rmh.1_Missense_Mutation_p.H90Y	NM_198578	NP_940980	Q5S007	LRRK2_HUMAN	leucine-rich repeat kinase 2	468					activation of MAPKK activity|determination of adult lifespan|exploration behavior|intracellular distribution of mitochondria|negative regulation of branching morphogenesis of a nerve|negative regulation of dendritic spine morphogenesis|negative regulation of neuroblast proliferation|negative regulation of neuron maturation|neuromuscular junction development|neuron death|peptidyl-serine phosphorylation|positive regulation of autophagy|positive regulation of dopamine receptor signaling pathway|positive regulation of programmed cell death|positive regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of protein phosphorylation|positive regulation of protein ubiquitination|protein autophosphorylation|regulation of kidney size|regulation of locomotion|regulation of membrane potential|response to oxidative stress|small GTPase mediated signal transduction|tangential migration from the subventricular zone to the olfactory bulb	external side of mitochondrial outer membrane	ATP binding|GTP binding|GTP-dependent protein kinase activity|GTPase activator activity|MAP kinase kinase activity|protein homodimerization activity|tubulin binding			ovary(12)|stomach(5)|upper_aerodigestive_tract(2)|lung(2)|large_intestine(1)|urinary_tract(1)|pancreas(1)	24	all_cancers(12;0.00108)|Breast(8;0.218)	Lung NSC(34;0.0942)|all_lung(34;0.11)				AATGCTAAATCATCTTTTTGA	0.318		NA											13	120					0	0	0	0
MLL2	8085	broad.mit.edu	37	12	49434415	49434415	+	Nonsense_Mutation	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr12:49434415G>A	uc001rta.3	-	31	7138	c.7138C>T	c.(7138-7140)CAG>TAG	p.Q2380*		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	2380	Pro-rich.				chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						AATGGGGGCTGAGCATATGGG	0.652		NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			4	37					0	0	0	0
KRR1	11103	broad.mit.edu	37	12	75905362	75905362	+	Silent	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr12:75905362G>A	uc001sxt.2	-	1	57	c.16C>T	c.(16-18)CTG>TTG	p.L6L	KRR1_uc009zsc.2_Silent_p.L6L|KRR1_uc010stx.1_Silent_p.L6L	NM_007043	NP_008974	Q13601	KRR1_HUMAN	HIV-1 rev binding protein 2	6					rRNA processing	nucleolus|ribonucleoprotein complex	RNA binding			ovary(1)|pancreas(1)	2						GGCCGCTCCAGCGAGGGAGAC	0.527		NA											6	69					0	0	0	0
PPFIA2	8499	broad.mit.edu	37	12	81839428	81839428	+	Silent	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr12:81839428C>T	uc001szo.1	-	6	638	c.477G>A	c.(475-477)CGG>CGA	p.R159R	PPFIA2_uc010sue.1_Silent_p.R59R|PPFIA2_uc010sug.1_RNA|PPFIA2_uc010suh.1_RNA|PPFIA2_uc010sui.1_RNA|PPFIA2_uc010suj.1_RNA|PPFIA2_uc009zsi.1_RNA	NM_003625	NP_003616	B7Z663	B7Z663_HUMAN	PTPRF interacting protein alpha 2	85										ovary(3)|lung(2)|pancreas(1)	6						ACTGGGCTTGCCGTTTTACCA	0.428		NA											3	48					0	0	0	0
STAB2	55576	broad.mit.edu	37	12	104067821	104067821	+	Silent	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr12:104067821C>T	uc001tjw.2	+	23	2694	c.2508C>T	c.(2506-2508)TTC>TTT	p.F836F		NM_017564	NP_060034	Q8WWQ8	STAB2_HUMAN	stabilin 2 precursor	836	Extracellular (Potential).|EGF-like 7.				angiogenesis|cell adhesion|defense response to bacterium|receptor-mediated endocytosis	cytoplasm|external side of plasma membrane|integral to plasma membrane	Gram-negative bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			ovary(9)|skin(5)	14						ACGTGCAGTTCTGTCACATCC	0.562		NA											23	53					0	0	0	0
USP30	84749	broad.mit.edu	37	12	109522853	109522853	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr12:109522853C>T	uc010sxi.1	+	12	1368	c.1264C>T	c.(1264-1266)CCT>TCT	p.P422S	USP30_uc001tnu.3_Missense_Mutation_p.P391S|USP30_uc001tnw.3_Missense_Mutation_p.P139S	NM_032663	NP_116052	Q70CQ3	UBP30_HUMAN	ubiquitin specific peptidase 30	422	Cytoplasmic (Potential).				ubiquitin-dependent protein catabolic process	integral to membrane|mitochondrial outer membrane	cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(1)	1						GATGCCCTTCCCTCTCCCAGT	0.502		NA											29	283					0	0	0	0
GPR81	27198	broad.mit.edu	37	12	123214555	123214555	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr12:123214555G>A	uc001ucz.2	-	1	575	c.332C>T	c.(331-333)GCG>GTG	p.A111V	GPR81_uc001ucw.1_RNA	NM_032554	NP_115943	Q9BXC0	HCAR1_HUMAN	G protein-coupled receptor 81	111	Cytoplasmic (Potential).				response to estradiol stimulus	integral to membrane|plasma membrane	G-protein coupled receptor activity				0	all_neural(191;0.0837)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.14e-05)|Epithelial(86;3.25e-05)|BRCA - Breast invasive adenocarcinoma(302;0.197)		ATACCTGTCCGCAGCCACCAC	0.622		NA											6	41					0	0	0	0
TRPC4	7223	broad.mit.edu	37	13	38357421	38357421	+	Missense_Mutation	SNP	C	C	T	rs75129764	byFrequency	TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr13:38357421C>T	uc001uws.2	-	2	285	c.50G>A	c.(49-51)CGC>CAC	p.R17H	TRPC4_uc010abv.2_5'UTR|TRPC4_uc001uwt.2_Missense_Mutation_p.R17H|TRPC4_uc010tey.1_Missense_Mutation_p.R17H|TRPC4_uc010abw.2_Missense_Mutation_p.R17H|TRPC4_uc010abx.2_Missense_Mutation_p.R17H|TRPC4_uc010aby.2_Missense_Mutation_p.R17H	NM_016179	NP_057263	Q9UBN4	TRPC4_HUMAN	transient receptor potential cation channel,	17	Cytoplasmic (Potential).				axon guidance|calcium ion import	basolateral plasma membrane|calcium channel complex|cell surface|cortical cytoskeleton	beta-catenin binding|cadherin binding|store-operated calcium channel activity			ovary(3)|skin(2)|breast(1)	6				all cancers(112;1.92e-08)|Epithelial(112;5.04e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000677)|GBM - Glioblastoma multiforme(144;0.00623)|BRCA - Breast invasive adenocarcinoma(63;0.0126)		TAGAGGGATGCGGTCTCTATA	0.398		NA											4	125					0	0	0	0
FNDC3A	22862	broad.mit.edu	37	13	49742771	49742771	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr13:49742771A>G	uc001vcm.2	+	10	1365	c.1060A>G	c.(1060-1062)ATA>GTA	p.I354V	FNDC3A_uc001vcn.2_Missense_Mutation_p.I354V|FNDC3A_uc001vco.2_RNA|FNDC3A_uc001vcp.1_Missense_Mutation_p.I298V|FNDC3A_uc001vcq.2_Missense_Mutation_p.I298V	NM_001079673	NP_001073141	Q9Y2H6	FND3A_HUMAN	fibronectin type III domain containing 3A	354	Fibronectin type-III 1.					Golgi membrane|integral to membrane				lung(2)	2		all_lung(13;7.44e-08)|Lung NSC(96;4.08e-06)|Breast(56;0.000111)|Prostate(109;0.00174)|Myeloproliferative disorder(33;0.0179)|Hepatocellular(98;0.0207)|Lung SC(185;0.187)|all_neural(104;0.19)	KIRC - Kidney renal clear cell carcinoma(9;0.206)	GBM - Glioblastoma multiforme(99;2.94e-09)		ATATAATTCTATAAAGGGAAC	0.368		NA											24	56					0	0	0	0
SLC35F4	341880	broad.mit.edu	37	14	58056063	58056063	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr14:58056063T>C	uc001xdb.1	-	3	566	c.566A>G	c.(565-567)TAT>TGT	p.Y189C	SLC35F4_uc010aoz.1_RNA|SLC35F4_uc010apa.1_Missense_Mutation_p.Y30C	NM_001080455	NP_001073924			solute carrier family 35, member F4											ovary(2)	2						GAAGTTCTTATAAGTAATTTT	0.393		NA											18	32					0	0	0	0
RYR3	6263	broad.mit.edu	37	15	33916108	33916108	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr15:33916108A>G	uc001zhi.2	+	20	2528	c.2458A>G	c.(2458-2460)AGA>GGA	p.R820G	RYR3_uc010bar.2_Missense_Mutation_p.R820G	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	820	Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		AGAGAAGATGAGATTGGAGCC	0.488		NA											24	95					0	0	0	0
SLC12A6	9990	broad.mit.edu	37	15	34526146	34526146	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr15:34526146T>A	uc001zhw.2	-	25	3553	c.3389A>T	c.(3388-3390)GAG>GTG	p.E1130V	SLC12A6_uc001zhv.2_Missense_Mutation_p.E1079V|SLC12A6_uc001zhx.2_Missense_Mutation_p.E1115V|SLC12A6_uc001zhy.2_RNA|SLC12A6_uc001zhz.2_RNA|SLC12A6_uc001zia.2_Missense_Mutation_p.E1071V|SLC12A6_uc001zib.2_Missense_Mutation_p.E1121V|SLC12A6_uc001zic.2_Missense_Mutation_p.E1130V|SLC12A6_uc010bau.2_Missense_Mutation_p.E1130V|SLC12A6_uc001zid.2_Missense_Mutation_p.E1071V|SLC12A6_uc001zht.2_RNA|SLC12A6_uc001zhu.2_Missense_Mutation_p.E942V	NM_133647	NP_598408	Q9UHW9	S12A6_HUMAN	solute carrier family 12, member 6 isoform a	1130	Cytoplasmic (Potential).				angiogenesis|cellular hypotonic salinity response|potassium ion transport|sodium ion transport	basolateral plasma membrane|integral to membrane	potassium:chloride symporter activity			central_nervous_system(5)|ovary(1)|skin(1)	7		all_lung(180;2.78e-08)		all cancers(64;3.43e-17)|GBM - Glioblastoma multiforme(113;2.6e-07)|BRCA - Breast invasive adenocarcinoma(123;0.0301)	Potassium Chloride(DB00761)	CTCTAGTCCCTCGGTAAGCAC	0.453		NA											10	59					0	0	0	0
DUOX1	53905	broad.mit.edu	37	15	45445673	45445673	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr15:45445673G>A	uc001zus.1	+	27	3866	c.3520G>A	c.(3520-3522)GAT>AAT	p.D1174N	DUOX1_uc001zut.1_Missense_Mutation_p.D1174N|DUOX1_uc010bee.1_Missense_Mutation_p.D554N	NM_017434	NP_059130	Q9NRD9	DUOX1_HUMAN	dual oxidase 1 precursor	1174	Ferric oxidoreductase.|Interaction with TXNDC11 (By similarity).|Extracellular (Potential).				cuticle development|cytokine-mediated signaling pathway|hormone biosynthetic process|hydrogen peroxide biosynthetic process|hydrogen peroxide catabolic process|response to cAMP|superoxide anion generation	apical plasma membrane|integral to membrane	calcium ion binding|electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|NADP binding|peroxidase activity			ovary(5)|skin(2)|breast(1)	8		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;5.77e-18)|GBM - Glioblastoma multiforme(94;5.11e-07)|COAD - Colon adenocarcinoma(120;0.071)|Colorectal(133;0.0717)		CTTCCATGATGATGGGTGAGT	0.378		NA											18	106					0	0	0	0
NTN3	4917	broad.mit.edu	37	16	2522266	2522266	+	Silent	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr16:2522266C>T	uc002cqj.2	+	1	767	c.564C>T	c.(562-564)AGC>AGT	p.S188S	TBC1D24_uc002cqk.2_5'Flank|TBC1D24_uc002cql.2_5'Flank	NM_006181	NP_006172	O00634	NET3_HUMAN	netrin 3 precursor	188	Laminin N-terminal.				axon guidance|muscle cell differentiation|positive regulation of muscle cell differentiation	proteinaceous extracellular matrix				central_nervous_system(1)	1						CTGATGGCAGCGGCCTTCTGG	0.697		NA											5	16					0	0	0	0
CREBBP	1387	broad.mit.edu	37	16	3786770	3786770	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr16:3786770C>T	uc002cvv.2	-	27	4645	c.4441G>A	c.(4441-4443)GAT>AAT	p.D1481N	CREBBP_uc002cvw.2_Missense_Mutation_p.D1443N	NM_004380	NP_004371	Q92793	CBP_HUMAN	CREB binding protein isoform a	1481	Cys/His-rich.|Interaction with TRERF1.				cellular lipid metabolic process|homeostatic process|interspecies interaction between organisms|N-terminal peptidyl-lysine acetylation|protein complex assembly|response to hypoxia	cytoplasm|nuclear body	histone acetyltransferase activity|MyoD binding|p53 binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription coactivator activity|zinc ion binding			haematopoietic_and_lymphoid_tissue(97)|ovary(14)|lung(6)|skin(6)|breast(2)|NS(1)|pancreas(1)	127		Ovarian(90;0.0266)		OV - Ovarian serous cystadenocarcinoma(1;3.54e-05)		AAGATGTAATCATCTCCTTCA	0.527		NA	T|N|F|Mis|O	MLL|MORF|RUNXBP2	ALL|AML|DLBCL|B-NHL 		Rubinstein-Taybi syndrome		Rubinstein-Taybi_syndrome				28	133					0	0	0	0
SETD1A	9739	broad.mit.edu	37	16	30977192	30977192	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr16:30977192G>A	uc002ead.1	+	8	2676	c.1990G>A	c.(1990-1992)GAG>AAG	p.E664K		NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	664					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						GAACTCCTTGGAGCTCATGGA	0.622		NA											10	89					0	0	0	0
ACD	65057	broad.mit.edu	37	16	67692699	67692699	+	Silent	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr16:67692699G>A	uc002etq.3	-	8	1261	c.924C>T	c.(922-924)GTC>GTT	p.V308V	ACD_uc002etp.3_Silent_p.V305V|ACD_uc002etr.3_Silent_p.V305V|ACD_uc010vjt.1_3'UTR|PARD6A_uc002ets.2_5'Flank|PARD6A_uc002ett.2_5'Flank|PARD6A_uc002etu.2_5'Flank	NM_001082486	NP_001075955	Q96AP0	ACD_HUMAN	adrenocortical dysplasia homolog isoform 1	308	Interaction with POT1.				intracellular protein transport|negative regulation of telomere maintenance via telomerase|positive regulation of single-stranded telomeric DNA binding|positive regulation of telomerase activity|protection from non-homologous end joining at telomere|protein localization to chromosome, telomeric region|telomere assembly	nuclear telomere cap complex|nucleoplasm	DNA binding|DNA polymerase binding			pancreas(1)	1		Acute lymphoblastic leukemia(13;3.76e-06)|all_hematologic(13;0.000303)|Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.047)|all cancers(182;0.228)		TTGAGCTGGGGACAGTGTACA	0.552		NA											9	51					0	0	0	0
RANBP10	57610	broad.mit.edu	37	16	67778207	67778207	+	Silent	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr16:67778207C>T	uc002eud.2	-	4	668	c.552G>A	c.(550-552)AAG>AAA	p.K184K	RANBP10_uc010ceo.2_5'UTR|RANBP10_uc010vju.1_Intron|RANBP10_uc010vjv.1_Silent_p.K67K|RANBP10_uc010vjx.1_Silent_p.K184K|RANBP10_uc010vjy.1_Silent_p.K52K	NM_020850	NP_065901	Q6VN20	RBP10_HUMAN	RAN binding protein 10	184	B30.2/SPRY.									ovary(1)	1		Acute lymphoblastic leukemia(13;4.34e-06)|all_hematologic(13;0.000643)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00522)|Epithelial(162;0.025)|all cancers(182;0.157)		TGTGGCCATTCTTGGTGTAGA	0.582		NA											6	70					0	0	0	0
RTN4RL1	146760	broad.mit.edu	37	17	1840605	1840605	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr17:1840605C>T	uc002ftp.2	-	2	530	c.511G>A	c.(511-513)GAC>AAC	p.D171N		NM_178568	NP_848663	Q86UN2	R4RL1_HUMAN	reticulon 4 receptor-like 1 precursor	171	LRR 5.				axon regeneration	anchored to plasma membrane	receptor activity				0						TTGACCAGGTCCACGAAGATG	0.627		NA											7	44					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7578394	7578394	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr17:7578394T>C	uc002gim.2	-	5	730	c.536A>G	c.(535-537)CAT>CGT	p.H179R	TP53_uc002gig.1_Missense_Mutation_p.H179R|TP53_uc002gih.2_Missense_Mutation_p.H179R|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.H47R|TP53_uc010cng.1_Missense_Mutation_p.H47R|TP53_uc002gii.1_Missense_Mutation_p.H47R|TP53_uc010cnh.1_Missense_Mutation_p.H179R|TP53_uc010cni.1_Missense_Mutation_p.H179R|TP53_uc002gij.2_Missense_Mutation_p.H179R|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Missense_Mutation_p.H86R|TP53_uc002gio.2_Missense_Mutation_p.H47R|TP53_uc010vug.1_Missense_Mutation_p.H140R	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	179	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).	Zinc.	H -> Q (in sporadic cancers; somatic mutation).|H -> N (in sporadic cancers; somatic mutation).|H -> R (in sporadic cancers; somatic mutation).|HH -> QS (in a sporadic cancer; somatic mutation).|H -> L (in sporadic cancers; somatic mutation).|H -> D (in sporadic cancers; somatic mutation).|H -> P (in sporadic cancers; somatic mutation).|H -> Y (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.H179R(99)|p.H179Y(74)|p.H179L(31)|p.H179Q(17)|p.H179N(13)|p.H179D(10)|p.P177_C182delPHHERC(8)|p.0?(7)|p.C176_R181delCPHHER(3)|p.R174fs*24(3)|p.H179P(3)|p.R175_E180delRCPHHE(3)|p.H179fs*68(2)|p.H179H(2)|p.P177fs*3(2)|p.V173fs*59(2)|p.R174fs*1(2)|p.K164_P219del(1)|p.C176fs*65(1)|p.P177_H179delPHH(1)|p.V173fs*23(1)|p.V172_E180delVVRRCPHHE(1)|p.R174_H179delRRCPHH(1)|p.H179del(1)|p.E171_H179delEVVRRCPHH(1)|p.R81fs*24(1)|p.R174_E180>K(1)|p.H178fs*6(1)|p.P177_E180delPHHE(1)|p.R42fs*24(1)|p.E171fs*1(1)|p.R174fs*3(1)|p.H178_H179>QY(1)|p.E171fs*61(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GCAGCGCTCATGGTGGGGGCA	0.642		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			24	41					0	0	0	0
TP53I13	90313	broad.mit.edu	37	17	27896356	27896356	+	Silent	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr17:27896356C>T	uc002hee.2	+	3	200	c.162C>T	c.(160-162)TAC>TAT	p.Y54Y	ABHD15_uc002hed.1_5'Flank	NM_138349	NP_612358	Q8NBR0	P5I13_HUMAN	tumor protein p53 inducible protein 13	54	Extracellular (Potential).					cytoplasm|integral to membrane|plasma membrane					0				READ - Rectum adenocarcinoma(3;0.236)		GAGTGACCTACACACGAGTGA	0.622		NA											5	29					0	0	0	0
TADA2A	6871	broad.mit.edu	37	17	35825582	35825582	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr17:35825582A>G	uc002hnt.2	+	11	917	c.760A>G	c.(760-762)ATG>GTG	p.M254V	TADA2A_uc002hnu.1_Missense_Mutation_p.M254V|TADA2A_uc002hnv.2_Missense_Mutation_p.M254V|TADA2A_uc002hnw.2_Missense_Mutation_p.M153V|TADA2A_uc010cvb.2_Missense_Mutation_p.M50V	NM_001488	NP_001479	O75478	TAD2A_HUMAN	transcriptional adaptor 2A isoform a	254					histone H3 acetylation|transcription from RNA polymerase II promoter	chromosome|PCAF complex	DNA binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|zinc ion binding			breast(3)|skin(1)	4						GTATGAAACAATGAGGCGATT	0.433		NA											37	103					0	0	0	0
TNS4	84951	broad.mit.edu	37	17	38638646	38638646	+	Silent	SNP	G	G	T	rs147623676	byFrequency	TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr17:38638646G>T	uc010cxb.2	-	7	1688	c.1524C>A	c.(1522-1524)ATC>ATA	p.I508I	TNS4_uc002huu.3_5'Flank	NM_032865	NP_116254	Q8IZW8	TENS4_HUMAN	tensin 4 precursor	508	SH2.				apoptosis|protein localization	cytoplasm|cytoskeleton|focal adhesion	actin binding			large_intestine(1)|ovary(1)|central_nervous_system(1)|skin(1)	4		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(5;5.91e-05)			GGAAGTGTCGGATGAGGTCAT	0.453		NA											11	59					7.04e-09	7.67e-09	1	0
KCNH4	23415	broad.mit.edu	37	17	40327728	40327728	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr17:40327728A>G	uc002hzb.2	-	6	1189	c.856T>C	c.(856-858)TAT>CAT	p.Y286H		NM_012285	NP_036417	Q9UQ05	KCNH4_HUMAN	potassium voltage-gated channel, subfamily H,	286	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	voltage-gated potassium channel complex	two-component sensor activity|voltage-gated potassium channel activity			large_intestine(1)	1		all_cancers(22;1.24e-06)|all_epithelial(22;4.33e-05)|Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.126)		TGGGACACATAGGTGGTGCGG	0.552		NA											3	139					0	0	0	0
MPP2	4355	broad.mit.edu	37	17	41956730	41956730	+	Silent	SNP	C	C	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr17:41956730C>A	uc010wip.1	-	12	1587	c.1530G>T	c.(1528-1530)GTG>GTT	p.V510V	MPP2_uc002ien.1_Silent_p.V482V|MPP2_uc010wim.1_Silent_p.V454V|MPP2_uc002ieo.1_Silent_p.V465V|MPP2_uc010win.1_Silent_p.V326V|MPP2_uc010wio.1_Silent_p.V454V	NM_005374	NP_005365	Q14168	MPP2_HUMAN	palmitoylated membrane protein 2	489	Guanylate kinase-like.				signal transduction	cell surface|integral to plasma membrane|membrane fraction	guanylate kinase activity				0		Breast(137;0.00314)		BRCA - Breast invasive adenocarcinoma(366;0.12)		CGATGAACACCACGTAAGGGA	0.582		NA											18	78					5.39e-06	5.77e-06	1	0
EPN3	55040	broad.mit.edu	37	17	48618855	48618855	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr17:48618855G>A	uc002ira.3	+	9	1820	c.1385G>A	c.(1384-1386)AGT>AAT	p.S462N	SPATA20_uc002irc.2_5'Flank|EPN3_uc010wms.1_Missense_Mutation_p.S490N|EPN3_uc010wmt.1_RNA|EPN3_uc010wmu.1_Missense_Mutation_p.S435N	NM_017957	NP_060427	Q9H201	EPN3_HUMAN	epsin 3	462						clathrin-coated vesicle|nucleus|perinuclear region of cytoplasm	lipid binding			ovary(1)	1	Breast(11;1.23e-18)		BRCA - Breast invasive adenocarcinoma(22;2.88e-09)			CCCAGCCCCAGTTCCAAGCAA	0.577		NA											6	50					0	0	0	0
ACE	1636	broad.mit.edu	37	17	61561867	61561867	+	Missense_Mutation	SNP	A	A	C			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr17:61561867A>C	uc002jau.1	+	12	1908	c.1886A>C	c.(1885-1887)CAC>CCC	p.H629P	ACE_uc010ddu.1_Missense_Mutation_p.H446P|ACE_uc002jav.1_5'Flank|ACE_uc010ddv.1_5'Flank|ACE_uc010wpj.1_5'Flank|ACE_uc002jaw.1_5'Flank|ACE_uc010wpk.1_5'Flank	NM_000789	NP_000780	P12821	ACE_HUMAN	angiotensin I converting enzyme 1 isoform 1	629	Extracellular (Potential).|Peptidase M2 1.				arachidonic acid secretion|hormone catabolic process|kidney development|peptide catabolic process|regulation of smooth muscle cell migration	endosome|external side of plasma membrane|extracellular space|integral to membrane|membrane fraction|plasma membrane	actin binding|bradykinin receptor binding|carboxypeptidase activity|chloride ion binding|drug binding|metallopeptidase activity|peptidyl-dipeptidase activity|zinc ion binding			ovary(2)|upper_aerodigestive_tract(1)|pancreas(1)	4					Benazepril(DB00542)|Captopril(DB01197)|Deserpidine(DB01089)|Enalapril(DB00584)|Fosinopril(DB00492)|Lisinopril(DB00722)|Moexipril(DB00691)|Perindopril(DB00790)|Quinapril(DB00881)|Ramipril(DB00178)|Rescinnamine(DB01180)|Spirapril(DB01348)|Trandolapril(DB00519)	TACCAGTGGCACCCGCCGTTG	0.642		NA											4	13					0	0	0	0
TEX2	55852	broad.mit.edu	37	17	62291153	62291153	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr17:62291153C>T	uc002jec.2	-	2	598	c.425G>A	c.(424-426)GGG>GAG	p.G142E	TEX2_uc002jed.2_Missense_Mutation_p.G142E|TEX2_uc002jee.2_Missense_Mutation_p.G142E	NM_018469	NP_060939	Q8IWB9	TEX2_HUMAN	testis expressed sequence 2	142					signal transduction|sphingolipid metabolic process	integral to membrane				ovary(1)	1			BRCA - Breast invasive adenocarcinoma(8;1.33e-10)	READ - Rectum adenocarcinoma(1115;0.0689)		AGCTAAGGGCCCCGACGAAGA	0.527		NA											11	109					0	0	0	0
EPB41L3	23136	broad.mit.edu	37	18	5397374	5397375	+	Missense_Mutation	DNP	GC	GC	CA			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr18:5397374_5397375GC>CA	uc002kmt.1	-	18	2609_2610	c.2523_2524GC>TG	c.(2521-2526)GTGCAC>GTTGAC	p.H842D	EPB41L3_uc010wzh.1_Missense_Mutation_p.H673D|EPB41L3_uc002kmu.1_Missense_Mutation_p.H620D|EPB41L3_uc010dkq.1_Missense_Mutation_p.H511D|EPB41L3_uc002kms.1_Missense_Mutation_p.H77D|EPB41L3_uc010wze.1_Missense_Mutation_p.H147D|EPB41L3_uc010wzf.1_Missense_Mutation_p.H139D|EPB41L3_uc010wzg.1_Missense_Mutation_p.H114D|EPB41L3_uc010dkr.2_Missense_Mutation_p.H234D	NM_012307	NP_036439	Q9Y2J2	E41L3_HUMAN	erythrocyte membrane protein band 4.1-like 3	842	Spectrin--actin-binding (Potential).				cortical actin cytoskeleton organization	cell-cell junction|cytoplasm|cytoskeleton|extrinsic to membrane	actin binding|structural molecule activity			ovary(5)	5						GGCAGGTGGTGCACGGTGGGTT	0.569		NA											14	52					0	0	0	0
PSMA8	143471	broad.mit.edu	37	18	23772346	23772346	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr18:23772346G>A	uc002kvq.2	+	7	856	c.742G>A	c.(742-744)GAG>AAG	p.E248K	PSMA8_uc002kvo.2_Missense_Mutation_p.E204K|PSMA8_uc002kvp.2_Missense_Mutation_p.E242K|PSMA8_uc002kvr.2_Missense_Mutation_p.E216K	NM_144662	NP_653263	Q8TAA3	PSA7L_HUMAN	proteasome alpha 8 subunit isoform 1	248					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|M/G1 transition of mitotic cell cycle|mRNA metabolic process|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	cytoplasm|nucleus|proteasome core complex, alpha-subunit complex	threonine-type endopeptidase activity			skin(1)	1	all_cancers(21;0.000585)|Lung NSC(5;0.00148)|all_lung(6;0.0038)|Ovarian(20;0.124)		OV - Ovarian serous cystadenocarcinoma(3;0.000324)|all cancers(3;0.000954)|LUSC - Lung squamous cell carcinoma(2;0.181)			GGAAGAAGCAGAGAAGAAAAA	0.303		NA											9	47					0	0	0	0
POLI	11201	broad.mit.edu	37	18	51820401	51820401	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr18:51820401C>T	uc002lfj.3	+	10	1855	c.1787C>T	c.(1786-1788)TCT>TTT	p.S596F	POLI_uc010xds.1_Missense_Mutation_p.S517F|POLI_uc002lfk.3_Missense_Mutation_p.S493F|POLI_uc010dpg.2_Missense_Mutation_p.S192F	NM_007195	NP_009126	Q9UNA4	POLI_HUMAN	DNA polymerase iota	596	Ser-rich.				DNA repair|DNA replication	nucleoplasm	damaged DNA binding|DNA-directed DNA polymerase activity|metal ion binding|protein binding			ovary(2)|kidney(1)	3				Colorectal(16;0.0234)|READ - Rectum adenocarcinoma(59;0.197)		CAGGTATCCTCTGTATCTCCT	0.338		NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					20	56					0	0	0	0
ZADH2	284273	broad.mit.edu	37	18	72914175	72914175	+	Silent	SNP	A	A	G			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr18:72914175A>G	uc002llx.2	-	2	598	c.330T>C	c.(328-330)TCT>TCC	p.S110S	ZADH2_uc010dqv.2_5'UTR	NM_175907	NP_787103	Q8N4Q0	ZADH2_HUMAN	zinc binding alcohol dehydrogenase domain	110						peroxisome	oxidoreductase activity|zinc ion binding				0		Esophageal squamous(42;0.131)|Prostate(75;0.155)		READ - Rectum adenocarcinoma(2;0.0276)|BRCA - Breast invasive adenocarcinoma(31;0.216)		TGGCACTAGCAGAGAGGCCTA	0.537		NA											12	108					0	0	0	0
EMR1	2015	broad.mit.edu	37	19	6919744	6919744	+	Silent	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr19:6919744C>T	uc002mfw.2	+	13	1644	c.1606C>T	c.(1606-1608)CTG>TTG	p.L536L	EMR1_uc010dvc.2_Silent_p.L536L|EMR1_uc010dvb.2_Silent_p.L484L|EMR1_uc010xji.1_Silent_p.L395L|EMR1_uc010xjj.1_Silent_p.L359L	NM_001974	NP_001965	Q14246	EMR1_HUMAN	egf-like module containing, mucin-like, hormone	536	Ser/Thr-rich.|Extracellular (Potential).				cell adhesion|neuropeptide signaling pathway	integral to plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(3)|lung(1)|skin(1)	5	all_hematologic(4;0.166)					CATCTACACTCTGGAGAACAT	0.458		NA											7	61					0	0	0	0
ATG4D	84971	broad.mit.edu	37	19	10663623	10663623	+	Silent	SNP	T	T	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr19:10663623T>A	uc002mov.2	+	10	1425	c.1305T>A	c.(1303-1305)GCT>GCA	p.A435A	ATG4D_uc010xlh.1_Silent_p.A372A|ATG4D_uc010dxh.2_RNA|ATG4D_uc010dxi.2_RNA|ATG4D_uc010dxj.2_Silent_p.A102A	NM_032885	NP_116274	Q86TL0	ATG4D_HUMAN	APG4 autophagy 4 homolog D	435					autophagy|protein transport	cytoplasm	cysteine-type endopeptidase activity				0			Epithelial(33;9.2e-06)|all cancers(31;3.9e-05)			AGGGCCATGCTCAGGACCACA	0.672		NA											13	61					0	0	0	0
CLEC17A	388512	broad.mit.edu	37	19	14707912	14707912	+	Silent	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr19:14707912C>T	uc010dzn.1	+	10	662	c.585C>T	c.(583-585)TAC>TAT	p.Y195Y	CLEC17A_uc002mzh.1_Silent_p.Y178Y|CLEC17A_uc010xnt.1_RNA|CLEC17A_uc010xnu.1_Silent_p.Y195Y|CLEC17A_uc010dzo.1_Silent_p.Y195Y			Q6ZS10	CL17A_HUMAN	SubName: Full=CLEC17A protein;	195	Extracellular (Potential).					cell surface|integral to membrane	fucose binding|mannose binding|metal ion binding|receptor activity				0						TCTTCATAGACCAGGAGTTGA	0.493		NA											3	18					0	0	0	0
OR7A17	26333	broad.mit.edu	37	19	14991892	14991892	+	Silent	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr19:14991892G>A	uc010xob.1	-	1	276	c.276C>T	c.(274-276)ATC>ATT	p.I92I		NM_030901	NP_112163	O14581	OR7AH_HUMAN	olfactory receptor, family 7, subfamily A,	92	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	Ovarian(108;0.203)					CTGCATAGGTGATGACTCTGC	0.468		NA											15	77					0	0	0	0
CPAMD8	27151	broad.mit.edu	37	19	17057903	17057903	+	Silent	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr19:17057903C>T	uc002nfb.2	-	21	2816	c.2784G>A	c.(2782-2784)CTG>CTA	p.L928L		NM_015692	NP_056507	Q8IZJ3	CPMD8_HUMAN	C3 and PZP-like, alpha-2-macroglobulin domain	881						extracellular space|plasma membrane	serine-type endopeptidase inhibitor activity			ovary(4)|breast(4)|large_intestine(3)|pancreas(1)|skin(1)	13						TGTTGAGTCCCAGGTCGCTGA	0.592		NA											11	78					0	0	0	0
KIAA1683	80726	broad.mit.edu	37	19	18376204	18376204	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr19:18376204T>A	uc002nin.2	-	3	2362	c.2146A>T	c.(2146-2148)ATG>TTG	p.M716L	KIAA1683_uc010ebn.2_Missense_Mutation_p.M716L|KIAA1683_uc010xqe.1_Missense_Mutation_p.M670L	NM_025249	NP_079525	Q9H0B3	K1683_HUMAN	KIAA1683 isoform b	716						mitochondrion				ovary(2)	2						TGGGAATGCATCTTGCTCAGA	0.627		NA											8	54					0	0	0	0
ZNF90	7643	broad.mit.edu	37	19	20229657	20229657	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr19:20229657A>G	uc002nor.2	+	4	1433	c.1294A>G	c.(1294-1296)AAA>GAA	p.K432E	ZNF90_uc002nos.1_Intron|ZNF90_uc002not.1_Intron	NM_007138	NP_009069	Q03938	ZNF90_HUMAN	zinc finger protein 90	432	C2H2-type 10.					Golgi apparatus|nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|skin(1)	2						AGAATGTGACAAAGTCTTCAA	0.413		NA											3	13					0	0	0	0
ZNF536	9745	broad.mit.edu	37	19	31039805	31039805	+	Silent	SNP	C	C	T	rs147863190		TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr19:31039805C>T	uc002nsu.1	+	4	3417	c.3279C>T	c.(3277-3279)AGC>AGT	p.S1093S	ZNF536_uc010edd.1_Silent_p.S1093S	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1093					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					AGCAGAAGAGCGGTGCATGGA	0.537		NA											11	39					0	0	0	0
FCGBP	8857	broad.mit.edu	37	19	40367841	40367841	+	Silent	SNP	T	T	G			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr19:40367841T>G	uc002omp.3	-	29	13127	c.13119A>C	c.(13117-13119)GCA>GCC	p.A4373A		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Fc fragment of IgG binding protein precursor	4373	TIL 10.					extracellular region	protein binding			ovary(4)|skin(4)|central_nervous_system(1)	9	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			TCGTAAGGGGTGCAGGGGACG	0.627		NA											7	18					0	0	0	0
TNNT1	7138	broad.mit.edu	37	19	55652591	55652591	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr19:55652591T>G	uc002qjb.3	-	8	361	c.272A>C	c.(271-273)AAG>ACG	p.K91T	TNNT1_uc002qiz.3_Missense_Mutation_p.K21T|TNNT1_uc002qja.3_Missense_Mutation_p.K21T|TNNT1_uc002qjc.3_Missense_Mutation_p.K91T|TNNT1_uc002qje.3_Missense_Mutation_p.K80T|TNNT1_uc002qjd.3_Missense_Mutation_p.K80T|TNNT1_uc002qjf.2_Missense_Mutation_p.K87T	NM_003283	NP_003274	P13805	TNNT1_HUMAN	troponin T1, skeletal, slow isoform a	91					muscle filament sliding|negative regulation of muscle contraction	cytosol|troponin complex	tropomyosin binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.047)		CTCTTCCTCCTTCTTCCGCTG	0.592		NA									OREG0025677	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	9	50					0	0	0	0
MBOAT2	129642	broad.mit.edu	37	2	9008678	9008678	+	Silent	SNP	A	A	G			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr2:9008678A>G	uc002qzg.1	-	9	1018	c.885T>C	c.(883-885)GCT>GCC	p.A295A	MBOAT2_uc010yix.1_Silent_p.A295A	NM_138799	NP_620154	Q6ZWT7	MBOA2_HUMAN	O-acyltransferase (membrane bound) domain	295					phospholipid biosynthetic process	integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity				0	all_hematologic(175;0.127)|Acute lymphoblastic leukemia(172;0.155)					TAATGGCATCAGCTATAGAAA	0.333		NA											3	96					0	0	0	0
OTOF	9381	broad.mit.edu	37	2	26750743	26750743	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr2:26750743G>C	uc002rhk.2	-	3	311	c.184C>G	c.(184-186)CTG>GTG	p.L62V		NM_194248	NP_919224	Q9HC10	OTOF_HUMAN	otoferlin isoform a	62	Cytoplasmic (Potential).				cellular membrane fusion|sensory perception of sound|synaptic vesicle exocytosis	basolateral plasma membrane|cell junction|cytosol|endoplasmic reticulum membrane|integral to membrane|membrane fraction|synaptic vesicle membrane	calcium ion binding			ovary(3)|breast(2)|central_nervous_system(1)|pancreas(1)	7	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					TGAATCTCCAGCATCTCATTT	0.577		NA											11	79					0	0	0	0
FAM98A	25940	broad.mit.edu	37	2	33810258	33810258	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr2:33810258C>T	uc002rpa.1	-	8	1216	c.1142G>A	c.(1141-1143)GGA>GAA	p.G381E	FAM98A_uc010yne.1_Missense_Mutation_p.G186E|FAM98A_uc010ynd.1_Missense_Mutation_p.G212E|FAM98A_uc002roz.1_Missense_Mutation_p.G219E	NM_015475	NP_056290	Q8NCA5	FA98A_HUMAN	hypothetical protein LOC25940	382	Gly-rich.									ovary(1)	1	all_hematologic(175;0.115)					TGTCCAGCCTCCTTGATGCTT	0.577		NA											6	97					0	0	0	0
MAP4K3	8491	broad.mit.edu	37	2	39485697	39485697	+	Silent	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr2:39485697G>A	uc002rro.2	-	30	2431	c.2340C>T	c.(2338-2340)ACC>ACT	p.T780T	MAP4K3_uc002rrp.2_Silent_p.T759T|MAP4K3_uc010yns.1_Silent_p.T333T	NM_003618	NP_003609	Q8IVH8	M4K3_HUMAN	mitogen-activated protein kinase kinase kinase	780	CNH.				JNK cascade		ATP binding|protein binding|protein serine/threonine kinase activity|small GTPase regulator activity			ovary(3)|lung(3)|stomach(1)|pancreas(1)	8		all_hematologic(82;0.211)				TCTCCAGTTGGGTTACATGAG	0.328		NA											7	40					0	0	0	0
TTC7A	57217	broad.mit.edu	37	2	47300993	47300993	+	Silent	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr2:47300993C>T	uc002rvo.2	+	20	2876	c.2508C>T	c.(2506-2508)TTC>TTT	p.F836F	TTC7A_uc002rvm.2_Silent_p.F802F|TTC7A_uc010fbb.2_Silent_p.F860F|TTC7A_uc010fbc.2_Silent_p.F482F|TTC7A_uc002rvp.2_Silent_p.F717F|C2orf61_uc010fbd.2_Intron|TTC7A_uc002rvq.2_Silent_p.F576F|TTC7A_uc002rvr.2_Silent_p.F285F	NM_020458	NP_065191	Q9ULT0	TTC7A_HUMAN	tetratricopeptide repeat domain 7A	836	TPR 9.						binding			breast(1)|skin(1)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.18)	Lung(47;0.0792)|LUSC - Lung squamous cell carcinoma(58;0.114)			TTGACTGCTTCCTCACCGCCC	0.677		NA											10	24					0	0	0	0
NRXN1	9378	broad.mit.edu	37	2	50280535	50280535	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr2:50280535C>T	uc010fbp.2	-	4	1614	c.807G>A	c.(805-807)ATG>ATA	p.M269I	NRXN1_uc002rxb.3_Missense_Mutation_p.M1006I|NRXN1_uc010fbq.2_Missense_Mutation_p.M1374I|NRXN1_uc002rxe.3_Missense_Mutation_p.M1304I	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	269	Extracellular (Potential).				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			ACTCAGTTGTCATAGAGGAAG	0.483		NA											11	102					0	0	0	0
BMP10	27302	broad.mit.edu	37	2	69092867	69092867	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr2:69092867G>A	uc002sez.1	-	2	1330	c.1171C>T	c.(1171-1173)CCC>TCC	p.P391S		NM_014482	NP_055297	O95393	BMP10_HUMAN	bone morphogenetic protein 10 preproprotein	391					activin receptor signaling pathway|adult heart development|atrial cardiac muscle tissue morphogenesis|BMP signaling pathway|cardiac muscle cell proliferation|heart trabecula formation|negative regulation of cardiac muscle hypertrophy|negative regulation of cell growth|negative regulation of endothelial cell migration|Notch signaling pathway|pathway-restricted SMAD protein phosphorylation|positive regulation of cardiac muscle cell proliferation|positive regulation of cardiac muscle hypertrophy|positive regulation of pathway-restricted SMAD protein phosphorylation|positive regulation of transcription, DNA-dependent|sarcomere organization|ventricular cardiac muscle cell development|ventricular cardiac muscle tissue morphogenesis	cell surface|extracellular space|Z disc	cytokine activity|growth factor activity|receptor serine/threonine kinase binding			ovary(2)	2						AGCTTTGTGGGCACACAGCAG	0.512		NA											4	153					0	0	0	0
ANKRD36	375248	broad.mit.edu	37	2	97866192	97866192	+	Silent	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr2:97866192C>T	uc010yva.1	+	46	3031	c.2787C>T	c.(2785-2787)GCC>GCT	p.A929A	ANKRD36_uc002sxp.3_RNA	NM_001164315	NP_001157787	A6QL64	AN36A_HUMAN	ankyrin repeat domain 36	929											0						CCATTCAGGCCACAAGTGATG	0.333		NA											4	36					0	0	0	0
ACTR1B	10120	broad.mit.edu	37	2	98275416	98275416	+	Silent	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr2:98275416C>T	uc002syb.2	-	5	574	c.366G>A	c.(364-366)GAG>GAA	p.E122E		NM_005735	NP_005726	P42025	ACTY_HUMAN	ARP1 actin-related protein 1 homolog B,	122						centrosome|dynactin complex	ATP binding|protein binding			skin(1)	1						CTGCCGCCTTCTCCCGGTTCT	0.607		NA											25	348					0	0	0	0
ANAPC1	64682	broad.mit.edu	37	2	112608479	112608479	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr2:112608479C>A	uc002thi.2	-	14	1771	c.1524G>T	c.(1522-1524)AAG>AAT	p.K508N		NM_022662	NP_073153	Q9H1A4	APC1_HUMAN	anaphase promoting complex subunit 1	508					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|mitosis|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm				skin(2)	2						GAATAAAAACCTTTCCCACCT	0.378		NA											4	20					5.94e-07	6.42e-07	1	0
YSK4	80122	broad.mit.edu	37	2	135744631	135744631	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr2:135744631T>A	uc002tue.1	-	7	1842	c.1811A>T	c.(1810-1812)CAC>CTC	p.H604L	YSK4_uc002tuf.1_Intron|YSK4_uc010fnc.1_Intron|YSK4_uc010fnd.1_Missense_Mutation_p.H491L|YSK4_uc010zbg.1_Intron|YSK4_uc002tuh.3_Missense_Mutation_p.H332L|YSK4_uc002tui.3_Missense_Mutation_p.H621L	NM_025052	NP_079328	Q56UN5	YSK4_HUMAN	Yeast Sps1/Ste20-related kinase 4 isoform 1	604							ATP binding|protein serine/threonine kinase activity			stomach(2)|urinary_tract(1)|ovary(1)|breast(1)	5				BRCA - Breast invasive adenocarcinoma(221;0.112)		CTGAGTCCGGTGAGTTGATTG	0.453		NA											28	132					0	0	0	0
7-Mar	64844	broad.mit.edu	37	2	160599714	160599714	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr2:160599714G>A	uc002uax.2	+	3	418	c.296G>A	c.(295-297)TGT>TAT	p.C99Y	MARCH7_uc010foq.2_Missense_Mutation_p.C99Y|MARCH7_uc010zcn.1_Missense_Mutation_p.C99Y|MARCH7_uc010for.2_Missense_Mutation_p.C61Y	NM_022826	NP_073737	Q9H992	MARH7_HUMAN	axotrophin	99	Ser-rich.						ligase activity|zinc ion binding				0						TGTACAAACTGTACTACCTCA	0.403		NA											10	56					0	0	0	0
SCN9A	6335	broad.mit.edu	37	2	167133711	167133711	+	Missense_Mutation	SNP	G	G	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr2:167133711G>T	uc010fpl.2	-	16	2964	c.2623C>A	c.(2623-2625)CAG>AAG	p.Q875K	uc002udp.2_RNA	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	886	II.|Helical; Name=S5 of repeat II; (Potential).					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	CCAAAGAGCTGCATGCCGACC	0.468		NA											11	115					5.01e-05	5.32e-05	1	0
AOX1	316	broad.mit.edu	37	2	201507512	201507512	+	Silent	SNP	A	A	G			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr2:201507512A>G	uc002uvx.2	+	25	2936	c.2835A>G	c.(2833-2835)CTA>CTG	p.L945L	AOX1_uc010zhf.1_Silent_p.L501L|AOX1_uc010fsu.2_Silent_p.L311L	NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	945					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	AATGTGGACTATCCCCTGAGA	0.343		NA											9	59					0	0	0	0
C20orf103	24141	broad.mit.edu	37	20	9496129	9496129	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr20:9496129G>A	uc002wni.1	+	2	323	c.94G>A	c.(94-96)GAA>AAA	p.E32K	C20orf103_uc010zrc.1_Missense_Mutation_p.E32K	NM_012261	NP_036393	Q9UJQ1	CT103_HUMAN	chromosome 20 open reading frame 103 precursor	32	Extracellular (Potential).					integral to membrane				upper_aerodigestive_tract(1)|lung(1)|breast(1)	3			COAD - Colon adenocarcinoma(9;0.194)			GGCAGAACAAGAAGTGGAAAA	0.498		NA											8	44					0	0	0	0
SEC23B	10483	broad.mit.edu	37	20	18529385	18529385	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr20:18529385T>A	uc002wqz.1	+	16	2319	c.1876T>A	c.(1876-1878)TAC>AAC	p.Y626N	SEC23B_uc002wra.1_Missense_Mutation_p.Y626N|SEC23B_uc002wrb.1_Missense_Mutation_p.Y626N|SEC23B_uc010zsb.1_Missense_Mutation_p.Y608N|SEC23B_uc002wrc.1_Missense_Mutation_p.Y626N	NM_006363	NP_006354	Q15437	SC23B_HUMAN	Sec23 homolog B	626					ER to Golgi vesicle-mediated transport|intracellular protein transport	COPII vesicle coat|endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane	zinc ion binding			ovary(1)	1						GCCCATTCTCTACTCTTACTC	0.438		NA											14	52					0	0	0	0
BRWD1	54014	broad.mit.edu	37	21	40604128	40604128	+	Missense_Mutation	SNP	T	T	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr21:40604128T>A	uc002yxk.1	-	25	3114	c.2975A>T	c.(2974-2976)GAG>GTG	p.E992V	BRWD1_uc010goc.1_5'UTR|BRWD1_uc002yxl.2_Missense_Mutation_p.E992V|BRWD1_uc010god.1_5'Flank	NM_018963	NP_061836	Q9NSI6	BRWD1_HUMAN	bromodomain and WD repeat domain containing 1	992					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				skin(3)|ovary(1)	4		Prostate(19;8.44e-08)|all_epithelial(19;0.223)				TCTCCATGGCTCCTTATTAGG	0.299		NA											15	39					0	0	0	0
MTP18	51537	broad.mit.edu	37	22	30824464	30824464	+	Silent	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr22:30824464C>T	uc003ahw.1	+	4	592	c.444C>T	c.(442-444)CTC>CTT	p.L148L	SEC14L2_uc010gvw.1_Intron|MTP18_uc010gvx.1_Missense_Mutation_p.S59F|MTP18_uc003ahv.1_Silent_p.L310L|MTP18_uc010gvy.1_Missense_Mutation_p.S51F|MTP18_uc003ahx.1_Missense_Mutation_p.P71S	NM_016498	NP_057582	Q9UDX5	MTFP1_HUMAN	mitochondrial protein 18 kDa isoform a	148	Helical; (Potential).				apoptosis|carbon utilization	integral to membrane|mitochondrial inner membrane	carbonate dehydratase activity|zinc ion binding				0						TGGATTTCCTCCTGGACTCCA	0.587		NA											10	35					0	0	0	0
ZNF501	115560	broad.mit.edu	37	3	44776296	44776296	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr3:44776296A>G	uc003cnu.1	+	3	784	c.383A>G	c.(382-384)CAT>CGT	p.H128R	ZNF501_uc003cnv.1_Missense_Mutation_p.H128R	NM_145044	NP_659481	Q96CX3	ZN501_HUMAN	zinc finger protein 501	128	C2H2-type 4.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0				BRCA - Breast invasive adenocarcinoma(193;0.00843)|KIRC - Kidney renal clear cell carcinoma(197;0.0463)|Kidney(197;0.0579)		CAGCGAATTCATACTGGAGAG	0.408		NA											18	33					0	0	0	0
BSN	8927	broad.mit.edu	37	3	49689519	49689519	+	Nonsense_Mutation	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr3:49689519C>T	uc003cxe.3	+	5	2644	c.2530C>T	c.(2530-2532)CGA>TGA	p.R844*		NM_003458	NP_003449	Q9UPA5	BSN_HUMAN	bassoon protein	844					synaptic transmission	cell junction|cytoplasm|cytoskeleton|nucleus|synaptosome	metal ion binding			ovary(5)|pancreas(1)|central_nervous_system(1)|skin(1)	8				BRCA - Breast invasive adenocarcinoma(193;6.66e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0032)|Kidney(197;0.00336)		GGATTTCATGCGACGGCAGAT	0.622		NA											12	24					0	0	0	0
DCP1A	55802	broad.mit.edu	37	3	53381537	53381537	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr3:53381537G>A	uc003dgs.3	-	1	101	c.8C>T	c.(7-9)GCG>GTG	p.A3V	DCP1A_uc003dgt.3_RNA	NM_018403	NP_060873	Q9NPI6	DCP1A_HUMAN	DCP1 decapping enzyme homolog A	3					exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	cytoplasmic mRNA processing body|cytosol|nucleus	hydrolase activity|protein binding				0				BRCA - Breast invasive adenocarcinoma(193;0.000164)|KIRC - Kidney renal clear cell carcinoma(197;0.00525)|Kidney(197;0.00579)|OV - Ovarian serous cystadenocarcinoma(275;0.0647)		TCGACTCAGCGCCTCCATCTT	0.622		NA											7	44					0	0	0	0
POLQ	10721	broad.mit.edu	37	3	121206399	121206399	+	Silent	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr3:121206399G>A	uc003eee.3	-	16	5508	c.5379C>T	c.(5377-5379)TTC>TTT	p.F1793F	POLQ_uc003eed.2_Silent_p.F965F	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	1793					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		TGTTGTCTTTGAACCCATTTC	0.378		NA						DNA_polymerases_(catalytic_subunits)					8	107					0	0	0	0
GOLGB1	2804	broad.mit.edu	37	3	121410866	121410866	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr3:121410866T>C	uc003eei.3	-	14	7456	c.7330A>G	c.(7330-7332)ACA>GCA	p.T2444A	GOLGB1_uc010hrc.2_Missense_Mutation_p.T2449A|GOLGB1_uc003eej.3_Missense_Mutation_p.T2410A	NM_004487	NP_004478	Q14789	GOGB1_HUMAN	golgi autoantigen, golgin subfamily b,	2444	Cytoplasmic (Potential).|Potential.				Golgi organization	ER-Golgi intermediate compartment|Golgi membrane|Golgi stack|integral to membrane	protein binding			ovary(6)|breast(2)|skin(2)	10				GBM - Glioblastoma multiforme(114;0.0989)		GTTTTCAGTGTTTCCATAAGC	0.393		NA											21	128					0	0	0	0
TFDP2	7029	broad.mit.edu	37	3	141692899	141692899	+	Silent	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr3:141692899C>T	uc003eun.3	-	8	1033	c.654G>A	c.(652-654)CAG>CAA	p.Q218Q	TFDP2_uc003euk.3_Silent_p.Q131Q|TFDP2_uc010hur.2_Silent_p.Q158Q|TFDP2_uc003eul.3_Silent_p.Q158Q|TFDP2_uc011bnf.1_Silent_p.Q121Q|TFDP2_uc011bng.1_Silent_p.Q82Q|TFDP2_uc003eum.3_Silent_p.Q158Q	NM_006286	NP_006277	Q14188	TFDP2_HUMAN	transcription factor Dp-2 (E2F dimerization	218					cell cycle	transcription factor complex	DNA binding|protein domain specific binding|sequence-specific DNA binding transcription factor activity|transcription cofactor activity|transcription factor binding			kidney(1)	1						CCTCCAGATTCTGACATTCCT	0.294		NA											31	82					0	0	0	0
LRPAP1	4043	broad.mit.edu	37	4	3520617	3520617	+	Silent	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr4:3520617C>T	uc003ghi.2	-	4	658	c.573G>A	c.(571-573)GAG>GAA	p.E191E		NM_002337	NP_002328	P30533	AMRP_HUMAN	low density lipoprotein receptor-related protein	191					negative regulation of protein binding|negative regulation of very-low-density lipoprotein particle clearance|protein folding|vesicle-mediated transport	cell surface|integral to membrane|plasma membrane	asialoglycoprotein receptor activity|heparin binding|low-density lipoprotein particle receptor binding|receptor antagonist activity|unfolded protein binding|very-low-density lipoprotein particle receptor binding			ovary(1)|skin(1)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.165)		TGCTCAGGGTCTCCAGCAGGA	0.393		NA											3	9					0	0	0	0
ARAP2	116984	broad.mit.edu	37	4	36162102	36162102	+	Silent	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr4:36162102G>A	uc003gsq.1	-	13	2759	c.2421C>T	c.(2419-2421)CTC>CTT	p.L807L	ARAP2_uc003gsr.1_Silent_p.L807L	NM_015230	NP_056045	Q8WZ64	ARAP2_HUMAN	ArfGAP with RhoGAP domain, ankyrin repeat and PH	807	Arf-GAP.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytosol	ARF GTPase activator activity|phosphatidylinositol-3,4,5-trisphosphate binding|zinc ion binding			ovary(1)|pancreas(1)|skin(1)	3						CTTCTTTGGTGAGAGATGCCA	0.289		NA											3	36					0	0	0	0
SLC30A9	10463	broad.mit.edu	37	4	42069198	42069198	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr4:42069198C>T	uc003gwl.2	+	14	1387	c.1241C>T	c.(1240-1242)ACT>ATT	p.T414I	SLC30A9_uc011byx.1_Missense_Mutation_p.T174I	NM_006345	NP_006336	Q6PML9	ZNT9_HUMAN	solute carrier family 30 (zinc transporter),	414					nucleotide-excision repair|zinc ion transport	cytoskeleton|integral to membrane|nucleus	cation transmembrane transporter activity|nucleotide binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(2)|ovary(1)	3						ATGGGCCTTACTTCTATAACA	0.333		NA											5	146					0	0	0	0
LRRC66	339977	broad.mit.edu	37	4	52861043	52861044	+	Missense_Mutation	DNP	GG	GG	AA			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr4:52861043_52861044GG>AA	uc003gzi.2	-	4	2157_2158	c.2144_2145CC>TT	c.(2143-2145)TCC>TTT	p.S715F		NM_001024611	NP_001019782	Q68CR7	LRC66_HUMAN	leucine rich repeat containing 66	715						integral to membrane				ovary(1)|central_nervous_system(1)|skin(1)	3						CTGAACTTATGGAGCTCAGAGT	0.53		NA											5	86					0	0	0	0
EPHA5	2044	broad.mit.edu	37	4	66197747	66197747	+	Silent	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr4:66197747C>T	uc003hcy.2	-	17	3145	c.2952G>A	c.(2950-2952)GAG>GAA	p.E984E	EPHA5_uc003hcx.2_Silent_p.E916E|EPHA5_uc003hcz.2_Silent_p.E962E|EPHA5_uc011cah.1_Silent_p.E985E|EPHA5_uc011cai.1_Silent_p.E963E|EPHA5_uc003hda.2_Silent_p.E985E	NM_004439	NP_004430	P54756	EPHA5_HUMAN	ephrin receptor EphA5 isoform a precursor	984	Cytoplasmic (Potential).|SAM.				cAMP-mediated signaling|neuron development	dendrite|external side of plasma membrane|integral to plasma membrane|neuronal cell body|perinuclear region of cytoplasm|rough endoplasmic reticulum	ATP binding|transmembrane-ephrin receptor activity			lung(19)|stomach(2)|ovary(2)|central_nervous_system(1)	24						CCATGAAAATCTCTGTATACC	0.433		NA								TSP Lung(17;0.13)			11	43					0	0	0	0
CXCL10	3627	broad.mit.edu	37	4	76943923	76943923	+	Missense_Mutation	SNP	T	T	G			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr4:76943923T>G	uc003hjl.3	-	2	179	c.109A>C	c.(109-111)AAT>CAT	p.N37H	ART3_uc003hji.2_Intron|ART3_uc003hjj.2_Intron|ART3_uc003hjk.2_Intron	NM_001565	NP_001556	P02778	CXL10_HUMAN	small inducible cytokine B10 precursor	37					blood circulation|cell surface receptor linked signaling pathway|cell-cell signaling|chemotaxis|inflammatory response|muscle organ development|positive regulation of cell proliferation	extracellular space	cAMP-dependent protein kinase regulator activity|chemokine activity				0			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			ACAGGTTGATTACTAATGCTG	0.408		NA											4	81					0	0	0	0
SEC31A	22872	broad.mit.edu	37	4	83774850	83774850	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr4:83774850A>G	uc003hnf.2	-	18	2191	c.2027T>C	c.(2026-2028)CTT>CCT	p.L676P	SEC31A_uc003hne.2_Missense_Mutation_p.L409P|SEC31A_uc011ccl.1_Missense_Mutation_p.L637P|SEC31A_uc003hnl.2_Missense_Mutation_p.L637P|SEC31A_uc003hng.2_Missense_Mutation_p.L676P|SEC31A_uc003hnh.2_Missense_Mutation_p.L676P|SEC31A_uc003hni.2_Missense_Mutation_p.L676P|SEC31A_uc003hnj.2_Missense_Mutation_p.L637P|SEC31A_uc011ccm.1_Missense_Mutation_p.L671P|SEC31A_uc011ccn.1_Missense_Mutation_p.L676P|SEC31A_uc003hnk.2_Missense_Mutation_p.L637P|SEC31A_uc003hnm.2_Missense_Mutation_p.L676P|SEC31A_uc003hnn.1_Missense_Mutation_p.L676P	NM_001077207	NP_001070675	O94979	SC31A_HUMAN	SEC31 homolog A isoform 1	676	WD 7.				COPII vesicle coating|post-translational protein modification|protein N-linked glycosylation via asparagine|protein transport|response to calcium ion	COPII vesicle coat|cytosol|endoplasmic reticulum membrane|perinuclear region of cytoplasm	calcium-dependent protein binding		SEC31A/JAK2(4)|SEC31A/ALK(3)	haematopoietic_and_lymphoid_tissue(4)|soft_tissue(3)|breast(1)	8		Hepatocellular(203;0.114)				TTCATTTTCAAGCCTGGTTCC	0.378		NA											14	40					0	0	0	0
THAP9	79725	broad.mit.edu	37	4	83839313	83839313	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr4:83839313G>A	uc003hnt.2	+	5	2067	c.1948G>A	c.(1948-1950)GAA>AAA	p.E650K	THAP9_uc003hns.1_Missense_Mutation_p.E506K|THAP9_uc003hnu.1_RNA|THAP9_uc003hnv.2_Missense_Mutation_p.E367K	NM_024672	NP_078948	Q9H5L6	THAP9_HUMAN	THAP domain containing 9	650							DNA binding|metal ion binding			ovary(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	5		Hepatocellular(203;0.114)				ATTTCAAGATGAAGTTTTTCT	0.398		NA											6	50					0	0	0	0
COPS4	51138	broad.mit.edu	37	4	83989672	83989672	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr4:83989672G>A	uc003hoa.2	+	9	1223	c.1084G>A	c.(1084-1086)GAA>AAA	p.E362K	COPS4_uc003hob.2_Missense_Mutation_p.E362K|COPS4_uc010ijw.2_Missense_Mutation_p.E394K|COPS4_uc010ijx.2_Intron	NM_016129	NP_057213	Q9BT78	CSN4_HUMAN	COP9 signalosome subunit 4	362	PCI.				cullin deneddylation	cytoplasm|signalosome	protein binding			kidney(1)	1		Hepatocellular(203;0.114)				AGTTCATTTTGAAAGTAAGAG	0.333		NA											5	44					0	0	0	0
TET2	54790	broad.mit.edu	37	4	106156428	106156428	+	Silent	SNP	A	A	G			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr4:106156428A>G	uc003hxk.2	+	3	1715	c.1329A>G	c.(1327-1329)ACA>ACG	p.T443T	TET2_uc011cez.1_Silent_p.T464T|TET2_uc003hxj.2_RNA|TET2_uc010ilp.1_Silent_p.T443T|TET2_uc003hxi.1_Silent_p.T443T	NM_001127208	NP_001120680	Q6N021	TET2_HUMAN	tet oncogene family member 2 isoform a	443					cell cycle|myeloid cell differentiation		metal ion binding|methylcytosine dioxygenase activity|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen			haematopoietic_and_lymphoid_tissue(732)|pancreas(1)	733		Myeloproliferative disorder(5;0.0393)		OV - Ovarian serous cystadenocarcinoma(123;7.18e-08)		AAAGTAACACAACACTTTTAA	0.463		NA	Mis N|F		MDS								22	45					0	0	0	0
KIAA0947	23379	broad.mit.edu	37	5	5461426	5461426	+	Missense_Mutation	SNP	C	C	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr5:5461426C>A	uc003jdm.3	+	13	2201	c.1979C>A	c.(1978-1980)ACT>AAT	p.T660N		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	660										ovary(1)|central_nervous_system(1)	2						ACAGATATTACTACTAAAGTA	0.393		NA											16	62					4.75e-09	5.2e-09	1	0
RNASEN	29102	broad.mit.edu	37	5	31409214	31409214	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr5:31409214C>T	uc003jhg.2	-	32	4162	c.3803G>A	c.(3802-3804)TGT>TAT	p.C1268Y	RNASEN_uc003jhh.2_Missense_Mutation_p.C1231Y	NM_013235	NP_037367	Q9NRR4	RNC_HUMAN	ribonuclease III, nuclear isoform 1	1268	Necessary for interaction with DGCR8 and pri-miRNA processing activity.|DRBM.				gene silencing by RNA|ribosome biogenesis|RNA processing	nucleolus|nucleoplasm	double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity				0						TGTCAAGCAACACTGCTGAAG	0.453		NA											8	51					0	0	0	0
SEMA6A	57556	broad.mit.edu	37	5	115782989	115782989	+	Silent	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr5:115782989G>A	uc010jck.2	-	19	3122	c.2413C>T	c.(2413-2415)CTG>TTG	p.L805L	SEMA6A_uc003krx.3_Silent_p.L822L|SEMA6A_uc011cwe.1_Silent_p.L184L|SEMA6A_uc003krv.3_Silent_p.L232L|SEMA6A_uc003krw.3_Silent_p.L282L|SEMA6A_uc010jcj.2_Silent_p.L349L	NM_020796	NP_065847	Q9H2E6	SEM6A_HUMAN	sema domain, transmembrane domain (TM), and	805	Cytoplasmic (Potential).|Pro-rich.				apoptosis|axon guidance|cell surface receptor linked signaling pathway|cytoskeleton organization|organ morphogenesis	axon|integral to membrane|plasma membrane	receptor activity			ovary(2)	2		all_cancers(142;0.00316)|all_epithelial(76;5.71e-05)|Prostate(80;0.00845)|Ovarian(225;0.0796)|Lung NSC(810;0.171)|all_lung(232;0.203)		OV - Ovarian serous cystadenocarcinoma(64;1.59e-08)|Epithelial(69;2e-08)|all cancers(49;5.7e-08)|COAD - Colon adenocarcinoma(49;0.151)		GAGGCCCGCAGGGGCAGGTCC	0.652		NA											7	50					0	0	0	0
HSD17B4	3295	broad.mit.edu	37	5	118865640	118865640	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr5:118865640C>T	uc003ksj.2	+	21	1942	c.1819C>T	c.(1819-1821)CCA>TCA	p.P607S	HSD17B4_uc011cwg.1_Missense_Mutation_p.P583S|HSD17B4_uc011cwh.1_Missense_Mutation_p.P589S|HSD17B4_uc011cwi.1_Missense_Mutation_p.P632S|HSD17B4_uc003ksk.3_Missense_Mutation_p.P460S|HSD17B4_uc011cwj.1_Missense_Mutation_p.P460S|HSD17B4_uc010jcn.1_Missense_Mutation_p.P345S|HSD17B4_uc010jco.1_Silent_p.H75H	NM_000414	NP_000405	P51659	DHB4_HUMAN	hydroxysteroid (17-beta) dehydrogenase 4	607	Enoyl-CoA hydratase 2.				bile acid biosynthetic process|fatty acid beta-oxidation using acyl-CoA oxidase	peroxisomal matrix	3-hydroxyacyl-CoA dehydrogenase activity|3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity|estradiol 17-beta-dehydrogenase activity|isomerase activity|long-chain-enoyl-CoA hydratase activity|protein binding|sterol binding|sterol transporter activity			ovary(1)|pancreas(1)	2		all_cancers(142;0.0206)|Prostate(80;0.0322)		OV - Ovarian serous cystadenocarcinoma(64;0.000247)|Epithelial(69;0.000849)|all cancers(49;0.0122)	NADH(DB00157)	GGATCTTGCACCAACATCTGG	0.363		NA											7	70					0	0	0	0
PCDHA4	56144	broad.mit.edu	37	5	140188443	140188443	+	Silent	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr5:140188443C>T	uc003lhi.2	+	1	1772	c.1671C>T	c.(1669-1671)GAC>GAT	p.D557D	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhh.1_Silent_p.D557D|PCDHA4_uc011daa.1_Silent_p.D557D	NM_018907	NP_061730	Q9UN74	PCDA4_HUMAN	protocadherin alpha 4 isoform 1 precursor	557	Cadherin 5.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCGTGCTGGACGAAAACGACA	0.667		NA											7	50					0	0	0	0
HIST1H2BB	3018	broad.mit.edu	37	6	26043662	26043662	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr6:26043662G>A	uc003nfu.2	-	1	224	c.224C>T	c.(223-225)GCG>GTG	p.A75V	HIST1H3C_uc003nfv.2_5'Flank	NM_021062	NP_066406	P33778	H2B1B_HUMAN	histone cluster 1, H2bb	75					nucleosome assembly	nucleosome|nucleus	DNA binding				0						AGCCTCGCCCGCGATGCGCTC	0.597		NA											36	89					0	0	0	0
HIST1H2AG	8969	broad.mit.edu	37	6	27101060	27101060	+	Silent	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr6:27101060G>A	uc003niw.2	+	1	244	c.210G>A	c.(208-210)GCG>GCA	p.A70A	HIST1H2BJ_uc003niu.1_5'Flank|HIST1H2BJ_uc003niv.2_5'Flank	NM_021064	NP_066408	P0C0S8	H2A1_HUMAN	histone cluster 1, H2ag	70					nucleosome assembly	nucleosome|nucleus	DNA binding|enzyme binding				0						CGGGCAACGCGGCCCGCGACA	0.647		NA											28	52					0	0	0	0
OR2J2	26707	broad.mit.edu	37	6	29141562	29141562	+	Silent	SNP	A	A	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr6:29141562A>T	uc011dlm.1	+	1	252	c.150A>T	c.(148-150)TCA>TCT	p.S50S		NM_030905	NP_112167	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J,	50	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCATCCTGTCATACGTGGACT	0.453		NA											6	288					0	0	0	0
DNAH8	1769	broad.mit.edu	37	6	38939413	38939413	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr6:38939413G>A	uc003ooe.1	+	81	12446	c.11846G>A	c.(11845-11847)CGA>CAA	p.R3949Q	DNAH8_uc003oog.1_Missense_Mutation_p.R398Q	NM_001371	NP_001362			dynein, axonemal, heavy polypeptide 8											skin(8)|ovary(7)|lung(2)|large_intestine(1)|central_nervous_system(1)|kidney(1)|pancreas(1)	21						GTACATGCTCGAAAGCTGATT	0.413		NA											4	31					0	0	0	0
HSP90AB1	3326	broad.mit.edu	37	6	44219502	44219502	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr6:44219502G>A	uc003oxa.1	+	9	1427	c.1343G>A	c.(1342-1344)CGC>CAC	p.R448H	HSP90AB1_uc011dvr.1_Missense_Mutation_p.R438H|HSP90AB1_uc003oxb.1_Missense_Mutation_p.R448H|HSP90AB1_uc011dvs.1_Missense_Mutation_p.R268H|HSP90AB1_uc003oxc.1_Missense_Mutation_p.R86H	NM_007355	NP_031381	P08238	HS90B_HUMAN	heat shock 90kDa protein 1, beta	448					axon guidance|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|positive regulation of nitric oxide biosynthetic process|protein folding|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|response to unfolded protein	cytosol|melanosome	ATP binding|nitric-oxide synthase regulator activity|TPR domain binding|unfolded protein binding			lung(3)|breast(1)	4	all_cancers(18;1.7e-05)|all_lung(25;0.00747)|Hepatocellular(11;0.00908)|Ovarian(13;0.0273)		Colorectal(64;0.00337)|COAD - Colon adenocarcinoma(64;0.00536)			TCCACTAACCGCCGCCGCCTG	0.468		NA											10	103					0	0	0	0
GSTA5	221357	broad.mit.edu	37	6	52701052	52701052	+	Missense_Mutation	SNP	T	T	C			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr6:52701052T>C	uc003pba.1	-	4	324	c.254A>G	c.(253-255)GAC>GGC	p.D85G		NM_153699	NP_714543	Q7RTV2	GSTA5_HUMAN	glutathione S-transferase alpha 5	85	GST C-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)	1	Lung NSC(77;0.0912)				Glutathione(DB00143)	CTCCTTCATGTCTTTCCCATA	0.453		NA											53	122					0	0	0	0
FHL5	9457	broad.mit.edu	37	6	97052644	97052644	+	Missense_Mutation	SNP	C	C	T	rs145856574	byFrequency	TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr6:97052644C>T	uc003pos.1	+	4	583	c.178C>T	c.(178-180)CGG>TGG	p.R60W	FHL5_uc003pot.1_Missense_Mutation_p.R60W	NM_020482	NP_065228	Q5TD97	FHL5_HUMAN	activator of cAMP-responsive element modulator	60	LIM zinc-binding 1.					nucleus	zinc ion binding			ovary(2)	2		all_cancers(76;1.57e-07)|Acute lymphoblastic leukemia(125;4.93e-10)|all_hematologic(75;3.55e-07)|all_epithelial(107;0.00266)|Colorectal(196;0.0341)|Lung NSC(302;0.204)		BRCA - Breast invasive adenocarcinoma(108;0.0948)		TTACAAAGACCGGCACTGGCA	0.433		NA											10	56					0	0	0	0
KLHL32	114792	broad.mit.edu	37	6	97414959	97414959	+	Missense_Mutation	SNP	G	G	C			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr6:97414959G>C	uc010kcm.1	+	2	495	c.23G>C	c.(22-24)AGT>ACT	p.S8T	KLHL32_uc003poy.2_Missense_Mutation_p.S8T|KLHL32_uc011ead.1_Missense_Mutation_p.S8T|KLHL32_uc003poz.2_5'UTR|KLHL32_uc011eae.1_Missense_Mutation_p.S8T	NM_052904	NP_443136	Q96NJ5	KLH32_HUMAN	kelch-like 32	8										ovary(3)|skin(1)	4		all_cancers(76;1.19e-06)|Acute lymphoblastic leukemia(125;5.83e-10)|all_hematologic(75;3.67e-07)|all_epithelial(107;0.00778)|Colorectal(196;0.122)		BRCA - Breast invasive adenocarcinoma(108;0.0558)		CGCTGCCTCAGGTATGCCCTG	0.483		NA											5	12					0	0	0	0
C6orf211	79624	broad.mit.edu	37	6	151785628	151785628	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr6:151785628G>A	uc003qok.1	+	4	692	c.433G>A	c.(433-435)GAG>AAG	p.E145K	C6orf211_uc011ees.1_Missense_Mutation_p.E26K	NM_024573	NP_078849	Q9H993	CF211_HUMAN	hypothetical protein LOC79624	145							protein binding				0			BRCA - Breast invasive adenocarcinoma(37;0.183)	OV - Ovarian serous cystadenocarcinoma(155;5.27e-11)		AGAATCAAAAGAGCAAAATTT	0.328		NA											6	37					0	0	0	0
TIAM2	26230	broad.mit.edu	37	6	155450482	155450482	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr6:155450482C>T	uc003qqb.2	+	6	1398	c.125C>T	c.(124-126)TCA>TTA	p.S42L	TIAM2_uc003qqe.2_Missense_Mutation_p.S42L	NM_012454	NP_036586	Q8IVF5	TIAM2_HUMAN	T-cell lymphoma invasion and metastasis 2	42					apoptosis|cellular lipid metabolic process|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|filopodium|growth cone|lamellipodium	receptor signaling protein activity|Rho guanyl-nucleotide exchange factor activity			ovary(3)|breast(1)	4		Ovarian(120;0.196)		OV - Ovarian serous cystadenocarcinoma(155;8.1e-13)|BRCA - Breast invasive adenocarcinoma(81;0.0053)		GAGGAAAAGTCATTGCATGGA	0.463		NA											7	37					0	0	0	0
VPS41	27072	broad.mit.edu	37	7	38796567	38796567	+	Silent	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr7:38796567C>T	uc003tgy.2	-	19	1592	c.1566G>A	c.(1564-1566)AAG>AAA	p.K522K	VPS41_uc003tgz.2_Silent_p.K497K|VPS41_uc010kxn.2_Silent_p.K433K	NM_014396	NP_055211	P49754	VPS41_HUMAN	vacuolar protein sorting 41 isoform 1	522					Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4						TGCCATAGTTCTTGTCATAGG	0.299		NA											7	48					0	0	0	0
C7orf25	79020	broad.mit.edu	37	7	42950074	42950074	+	Silent	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr7:42950074G>A	uc003thw.2	-	2	890	c.426C>T	c.(424-426)ATC>ATT	p.I142I	C7orf25_uc010kxq.2_Silent_p.I142I|C7orf25_uc003thx.3_Silent_p.I200I|C7orf25_uc010kxr.2_Silent_p.I200I	NM_024054	NP_076959	Q9BPX7	CG025_HUMAN	hypothetical protein LOC79020 b	142										skin(1)	1						CCTGCTCAATGATGCTTTTGT	0.507		NA											7	101					0	0	0	0
LANCL2	55915	broad.mit.edu	37	7	55466318	55466318	+	Silent	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr7:55466318C>T	uc003tqp.2	+	3	1103	c.525C>T	c.(523-525)GTC>GTT	p.V175V		NM_018697	NP_061167	Q9NS86	LANC2_HUMAN	LanC lantibiotic synthetase component C-like 2	175					negative regulation of transcription, DNA-dependent|positive regulation of abscisic acid mediated signaling pathway	cortical actin cytoskeleton|cytosol|nucleus|plasma membrane	ATP binding|catalytic activity|GTP binding|phosphatidylinositol-3-phosphate binding|phosphatidylinositol-4-phosphate binding|phosphatidylinositol-5-phosphate binding			ovary(1)|skin(1)	2	Breast(14;0.0379)		Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00128)|Epithelial(13;0.0706)			AGGAATGTGTCACAAAGTGAG	0.463		NA											8	40					0	0	0	0
LRCH4	4034	broad.mit.edu	37	7	100179491	100179491	+	Silent	SNP	G	G	A	rs149222783	byFrequency	TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr7:100179491G>A	uc003uvj.2	-	4	560	c.507C>T	c.(505-507)AAC>AAT	p.N169N	LRCH4_uc010lgz.2_RNA|LRCH4_uc003uvi.2_RNA|LRCH4_uc011kjx.1_RNA	NM_002319	NP_002310	O75427	LRCH4_HUMAN	leucine-rich repeats and calponin homology (CH)	169	LRR 6.				nervous system development	PML body	protein binding			large_intestine(1)|ovary(1)	2	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					ATTGGAGCTCGTTGCTGCTCA	0.612		NA											5	81					0	0	0	0
TRIM56	81844	broad.mit.edu	37	7	100731849	100731849	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr7:100731849C>T	uc003uxq.2	+	3	1487	c.1256C>T	c.(1255-1257)CCA>CTA	p.P419L	TRIM56_uc003uxr.2_Intron	NM_030961	NP_112223	Q9BRZ2	TRI56_HUMAN	tripartite motif-containing 56	419					defense response to virus|interferon-beta production|protein K63-linked ubiquitination|response to type I interferon	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			kidney(1)|central_nervous_system(1)|skin(1)	3	Lung NSC(181;0.136)|all_lung(186;0.182)					GCCCAGACCCCAAAAGAGGAA	0.642		NA											10	75					0	0	0	0
PSMC2	5701	broad.mit.edu	37	7	103007958	103007958	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr7:103007958A>G	uc003vbs.2	+	10	1013	c.943A>G	c.(943-945)ATT>GTT	p.I315V	SLC26A5_uc003vbt.1_Intron|SLC26A5_uc003vbu.1_Intron|SLC26A5_uc003vbv.1_Intron|PSMC2_uc011klo.1_Missense_Mutation_p.I178V	NM_002803	NP_002794	P35998	PRS7_HUMAN	proteasome 26S ATPase subunit 2	315					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|G1/S transition of mitotic cell cycle|interspecies interaction between organisms|M/G1 transition of mitotic cell cycle|mRNA metabolic process|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|regulation of apoptosis|regulation of cellular amino acid metabolic process|S phase of mitotic cell cycle|viral reproduction	mitochondrion|nucleus|proteasome complex	ATP binding|ATPase activity|protein binding				0						TAGAGGCAATATTAAAGTGCT	0.443		NA											59	39					0	0	0	0
PRSS1	5644	broad.mit.edu	37	7	142459743	142459743	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr7:142459743G>A	uc003wak.2	+	3	336	c.319G>A	c.(319-321)GAC>AAC	p.D107N	uc011krr.1_Intron|uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_Intron|PRSS1_uc011ksm.1_3'UTR|PRSS1_uc003wam.2_Missense_Mutation_p.D47N	NM_002769	NP_002760	P07477	TRY1_HUMAN	protease, serine, 1 preproprotein	107	Peptidase S1.	Charge relay system.			digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			TCTGAACAATGACATCATGTT	0.552		NA							Hereditary_Pancreatitis				17	86					0	0	0	0
FUT10	84750	broad.mit.edu	37	8	33246581	33246581	+	Missense_Mutation	SNP	C	C	T	rs17855839		TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr8:33246581C>T	uc003xje.2	-	4	1468	c.1112G>A	c.(1111-1113)CGG>CAG	p.R371Q	FUT10_uc003xjc.2_Missense_Mutation_p.R378Q|FUT10_uc003xjd.2_Missense_Mutation_p.R343Q|FUT10_uc011lbi.1_Missense_Mutation_p.R421Q|FUT10_uc003xjf.2_Missense_Mutation_p.R309Q|FUT10_uc003xjg.2_Missense_Mutation_p.R343Q|FUT10_uc003xjh.2_Missense_Mutation_p.R371Q	NM_032664	NP_116053	Q6P4F1	FUT10_HUMAN	fucosyltransferase 10	371	Lumenal (Potential).				embryo development|fertilization|hemopoiesis|L-fucose catabolic process|nervous system development|protein folding|protein glycosylation|protein targeting|wound healing	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			ovary(1)|pancreas(1)	2				KIRC - Kidney renal clear cell carcinoma(67;0.129)|Kidney(114;0.154)		TCCCCATTTCCGTTCCCTGAG	0.478		NA											37	98					0	0	0	0
SOX17	64321	broad.mit.edu	37	8	55372417	55372417	+	Silent	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr8:55372417C>T	uc003xsb.3	+	2	1311	c.1107C>T	c.(1105-1107)TTC>TTT	p.F369F		NM_022454	NP_071899	Q9H6I2	SOX17_HUMAN	SRY-box 17	369	Sox C-terminal.				angiogenesis|cardiac cell fate determination|endocardial cell differentiation|endocardium formation|endoderm formation|heart formation|heart looping|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of cell growth|outflow tract morphogenesis|positive regulation of transcription, DNA-dependent|protein destabilization|protein stabilization|regulation of embryonic development|renal system development|vasculogenesis|Wnt receptor signaling pathway	transcription factor complex	beta-catenin binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription factor binding|transcription regulatory region DNA binding			lung(1)	1		Lung NSC(129;0.109)|all_epithelial(80;0.176)|all_lung(136;0.181)	OV - Ovarian serous cystadenocarcinoma(7;1.9e-07)|Epithelial(17;1.7e-05)|all cancers(17;0.000159)			ATCTGCACTTCGTGTGCAAGC	0.662		NA											4	22					0	0	0	0
FER1L6	654463	broad.mit.edu	37	8	125113503	125113503	+	Silent	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr8:125113503G>A	uc003yqw.2	+	38	5255	c.5049G>A	c.(5047-5049)AAG>AAA	p.K1683K	uc003yqy.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	1683	C2 6.|Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			CTTTAGAGAAGATGGAGTGTA	0.483		NA											5	64					0	0	0	0
RRAGA	10670	broad.mit.edu	37	9	19050493	19050493	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr9:19050493C>T	uc003znj.2	+	1	1122	c.836C>T	c.(835-837)CCG>CTG	p.P279L		NM_006570	NP_006561	Q7L523	RRAGA_HUMAN	Ras-related GTP binding A	279					apoptosis|cellular protein localization|cellular response to amino acid stimulus|positive regulation of cytolysis|positive regulation of TOR signaling cascade|virus-host interaction	Golgi apparatus|lysosome|nucleus	GTP binding|phosphoprotein binding|protein heterodimerization activity|protein homodimerization activity				0						ATGTCAGATCCGTCGATCCCT	0.512		NA											8	134					0	0	0	0
RABEPK	10244	broad.mit.edu	37	9	127969967	127969967	+	Missense_Mutation	SNP	A	A	G	rs17855990		TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr9:127969967A>G	uc004bpi.2	+	4	351	c.178A>G	c.(178-180)AGA>GGA	p.R60G	RABEPK_uc004bph.1_Missense_Mutation_p.R60G|RABEPK_uc004bpj.2_Missense_Mutation_p.R60G|RABEPK_uc004bpk.2_Missense_Mutation_p.R60G|RABEPK_uc004bpl.1_Missense_Mutation_p.R60G|RABEPK_uc004bpm.2_Missense_Mutation_p.R60G	NM_005833	NP_005824	Q7Z6M1	RABEK_HUMAN	Rab9 effector protein with kelch motifs	60	Kelch 1.				receptor-mediated endocytosis|vesicle docking involved in exocytosis	endosome membrane|plasma membrane				ovary(1)	1						AAATCCAAACAGAAGCTTCTC	0.532		NA											8	141					0	0	0	0
C9orf96	169436	broad.mit.edu	37	9	136260872	136260872	+	Missense_Mutation	SNP	C	C	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr9:136260872C>T	uc004cdk.2	+	9	909	c.848C>T	c.(847-849)TCG>TTG	p.S283L	C9orf96_uc004cdl.2_RNA	NM_153710	NP_714921	Q8NE28	SGK71_HUMAN	hypothetical protein LOC169436	283	Protein kinase.						ATP binding|protein kinase activity			stomach(2)|central_nervous_system(2)	4				OV - Ovarian serous cystadenocarcinoma(145;1.06e-07)|Epithelial(140;1.28e-06)|all cancers(34;1.46e-05)		ATCGACCCCTCGGATCGAATA	0.493		NA											12	87					0	0	0	0
PTCHD1	139411	broad.mit.edu	37	X	23353314	23353314	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chrX:23353314G>A	uc004dal.3	+	1	330	c.322G>A	c.(322-324)GAC>AAC	p.D108N	PTCHD1_uc010nfu.1_Missense_Mutation_p.D108N	NM_173495	NP_775766	Q96NR3	PTHD1_HUMAN	patched domain containing 1	108					cognition|smoothened signaling pathway	integral to membrane|plasma membrane	hedgehog receptor activity			ovary(4)|kidney(1)|skin(1)	6						CAACATGCTGGACCAGCATCA	0.677		NA											7	26					0	0	0	0
AWAT1	158833	broad.mit.edu	37	X	69455943	69455943	+	Missense_Mutation	SNP	G	G	A			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chrX:69455943G>A	uc004dxy.2	+	3	250	c.209G>A	c.(208-210)AGG>AAG	p.R70K		NM_001013579	NP_001013597	Q58HT5	AWAT1_HUMAN	wax synthase 1	70					lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane	long-chain-alcohol O-fatty-acyltransferase activity			ovary(3)	3						GCCTGGGTAAGGAACTGGTGT	0.517		NA											11	91					0	0	0	0
MED12	9968	broad.mit.edu	37	X	70356763	70356763	+	Missense_Mutation	SNP	A	A	G			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chrX:70356763A>G	uc004dyy.2	+	38	5634	c.5435A>G	c.(5434-5436)TAT>TGT	p.Y1812C	MED12_uc011mpq.1_Missense_Mutation_p.Y1812C|MED12_uc004dyz.2_Missense_Mutation_p.Y1812C|MED12_uc004dza.2_Missense_Mutation_p.Y1659C|MED12_uc010nla.2_Missense_Mutation_p.Y438C	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	1812	Interaction with CTNNB1 and GLI3.				androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					AGCGGCCCTTATGGTGTGACA	0.592		NA											15	42					0	0	0	0
CT45A5	441521	broad.mit.edu	37	X	134947917	134947917	+	Nonsense_Mutation	SNP	G	G	T			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chrX:134947917G>T	uc004eze.2	-	3	653	c.408C>A	c.(406-408)TGC>TGA	p.C136*	CT45A5_uc011mvu.1_Nonsense_Mutation_p.C136*	NM_001007551	NP_001007552	Q6NSH3	CT455_HUMAN	cancer/testis antigen family 45, member A5	136											0						TTCGTCCAAGGCATCGGATTT	0.398		NA											26	95					2.28e-19	2.52e-19	1	0
TAF10	6881	broad.mit.edu	37	11	6633269	6633269	+	Frame_Shift_Del	DEL	C	C	-			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr11:6633269delC	uc001mej.1	-	1	177	c.152delG	c.(151-153)GGAfs	p.G51fs		NM_006284	NP_006275	Q12962	TAF10_HUMAN	TBP-related factor 10	51					histone deubiquitination|histone H3 acetylation|protein homooligomerization|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|viral reproduction	PCAF complex|perinuclear region of cytoplasm|STAGA complex|transcription factor TFIID complex|transcription factor TFTC complex	estrogen receptor binding|RNA polymerase binding|transcription coactivator activity				0		Medulloblastoma(188;0.00263)|all_neural(188;0.026)|Breast(177;0.0481)		Epithelial(150;2.9e-09)|BRCA - Breast invasive adenocarcinoma(625;0.129)		AGCCCCAGGTCCCCCCGCTGT	0.682		NA											2	4	---	---	---	---	NA	NA	NA	NA
TMEM131	23505	broad.mit.edu	37	2	98427639	98427639	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr2:98427639delT	uc002syh.3	-	18	2149	c.1920delA	c.(1918-1920)AAAfs	p.K640fs		NM_015348	NP_056163	Q92545	TM131_HUMAN	RW1 protein	640						integral to membrane				ovary(4)|central_nervous_system(2)	6						TCCCCTCTAATTTTTTTGCAG	0.393		NA											11	1148	---	---	---	---	NA	NA	NA	NA
MOCS3	27304	broad.mit.edu	37	20	49575960	49575962	+	In_Frame_Del	DEL	TGC	TGC	-			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr20:49575960_49575962delTGC	uc002xvy.1	+	1	598_600	c.581_583delTGC	c.(580-585)GTGCTG>GTG	p.L195del	DPM1_uc002xvw.1_5'Flank|DPM1_uc002xvx.1_5'Flank	NM_014484	NP_055299	O95396	MOCS3_HUMAN	molybdenum cofactor synthesis 3	195					enzyme active site formation via L-cysteine persulfide|Mo-molybdopterin cofactor biosynthetic process|tRNA thio-modification|tRNA wobble uridine modification|water-soluble vitamin metabolic process	cytosol	ATP binding|metal ion binding|nucleotidyltransferase activity|protein binding|thiosulfate sulfurtransferase activity|URM1 activating enzyme activity			skin(2)|ovary(1)	3						GACGCATGTGTGCTGGCGGGTCG	0.596		NA											15	55	---	---	---	---	NA	NA	NA	NA
ZFR	51663	broad.mit.edu	37	5	32407005	32407025	+	In_Frame_Del	DEL	GGCAGCTGTTGCAGCAGCAGC	GGCAGCTGTTGCAGCAGCAGC	-			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr5:32407005_32407025delGGCAGCTGTTGCAGCAGCAGC	uc003jhr.1	-	6	966_986	c.886_906delGCTGCTGCTGCAACAGCTGCC	c.(886-906)GCTGCTGCTGCAACAGCTGCCdel	p.AAAATAA296del	ZFR_uc010iun.1_In_Frame_Del_p.AAAATAA296del	NM_016107	NP_057191	Q96KR1	ZFR_HUMAN	zinc finger RNA binding protein	296_302	Ala-rich.				multicellular organismal development	chromosome|cytoplasm|nucleus	DNA binding|RNA binding|zinc ion binding				0				STAD - Stomach adenocarcinoma(35;0.19)		TCCCTGTCCAGGCAgctgttgcagcagcagcagcagctgct	0.294		NA											8	51	---	---	---	---	NA	NA	NA	NA
C8orf59	401466	broad.mit.edu	37	8	86129664	86129664	+	Frame_Shift_Del	DEL	T	T	-			TCGA-CR-6478-01A-11D-1870-08	TCGA-CR-6478-10A-01D-1870-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	c21f40c6-4260-4def-8cca-1c11895b35b0	047fe7f4-33c6-4080-8d2f-5849cd110a6c	g.chr8:86129664delT	uc010mac.1	-	3	305	c.65delA	c.(64-66)AACfs	p.N22fs	C8orf59_uc003ydd.2_Frame_Shift_Del_p.N22fs|C8orf59_uc010mad.1_Frame_Shift_Del_p.N22fs|C8orf59_uc003yde.2_Frame_Shift_Del_p.N22fs|C8orf59_uc011lfu.1_RNA	NM_001099670	NP_001093140	Q8N0T1	CH059_HUMAN	hypothetical protein LOC401466	22											0						AGCCTTAAAGTTTTTTTGGCT	0.343		NA											7	207	---	---	---	---	NA	NA	NA	NA
