Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	isArtifactMode	oxoGCut
MEGF6	1953	broad.mit.edu	37	1	3418409	3418409	+	Silent	SNP	C	C	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:3418409C>G	uc001akl.2	-	18	2492	c.2265G>C	c.(2263-2265)ACG>ACC	p.T755T	MEGF6_uc001akk.2_Silent_p.T650T	NM_001409	NP_001400	O75095	MEGF6_HUMAN	EGF-like-domain, multiple 3 precursor	755	EGF-like 12.					extracellular region	calcium ion binding			large_intestine(1)	1	all_cancers(77;0.00681)|all_epithelial(69;0.00301)|Ovarian(185;0.0634)|Lung NSC(156;0.0969)|all_lung(157;0.105)	all_epithelial(116;7.41e-22)|all_lung(118;8.3e-09)|Lung NSC(185;3.55e-06)|Breast(487;0.000659)|Renal(390;0.00121)|Hepatocellular(190;0.00308)|Myeloproliferative disorder(586;0.0255)|Lung SC(97;0.0262)|Ovarian(437;0.0308)|Medulloblastoma(700;0.211)		Epithelial(90;3.78e-37)|OV - Ovarian serous cystadenocarcinoma(86;6.86e-22)|GBM - Glioblastoma multiforme(42;1.96e-12)|Colorectal(212;6.15e-05)|COAD - Colon adenocarcinoma(227;0.000241)|Kidney(185;0.000448)|BRCA - Breast invasive adenocarcinoma(365;0.000779)|KIRC - Kidney renal clear cell carcinoma(229;0.00645)|STAD - Stomach adenocarcinoma(132;0.00669)|Lung(427;0.213)		GGCACTGCCCCGTGACCCCGT	0.706		NA											15	27					0	0	0	0
PER3	8863	broad.mit.edu	37	1	7895935	7895935	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:7895935G>A	uc001aoo.2	+	19	3476	c.3301G>A	c.(3301-3303)GAA>AAA	p.E1101K	PER3_uc001aop.2_Missense_Mutation_p.E1110K|PER3_uc010nzw.1_Missense_Mutation_p.E790K	NM_016831	NP_058515	P56645	PER3_HUMAN	period 3	1101					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	signal transducer activity			ovary(1)|pancreas(1)|skin(1)	3	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0234)|all cancers(8;8.58e-70)|GBM - Glioblastoma multiforme(8;1.81e-35)|Colorectal(212;2.06e-07)|COAD - Colon adenocarcinoma(227;1.92e-05)|Kidney(185;7.18e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000472)|STAD - Stomach adenocarcinoma(132;0.00118)|KIRC - Kidney renal clear cell carcinoma(229;0.00122)|READ - Rectum adenocarcinoma(331;0.0649)		TAATGTCGCCGAAGAGCCCAT	0.418		NA											21	35					0	0	0	0
RIMS3	9783	broad.mit.edu	37	1	41094945	41094945	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:41094945G>C	uc001cfu.1	-	6	1041	c.572C>G	c.(571-573)CCA>CGA	p.P191R	RIMS3_uc001cfv.1_Missense_Mutation_p.P191R	NM_014747	NP_055562	Q9UJD0	RIMS3_HUMAN	regulating synaptic membrane exocytosis 3	191	C2.				neurotransmitter transport	cell junction|synapse					0	Ovarian(52;0.00769)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1.47e-17)			TCCCTCACCTGGGAGGGATTT	0.592		NA											32	110					0	0	0	0
RNF220	55182	broad.mit.edu	37	1	44878355	44878355	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:44878355C>T	uc001clv.1	+	2	946	c.586C>T	c.(586-588)CGG>TGG	p.R196W	RNF220_uc001clw.1_Missense_Mutation_p.R196W	NM_018150	NP_060620	Q5VTB9	RN220_HUMAN	ring finger protein 220	196					protein autoubiquitination	cytoplasm	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)	2						CATTTCTGATCGGGAAGCCTC	0.512		NA											46	92					0	0	0	0
SSBP3	23648	broad.mit.edu	37	1	54722843	54722843	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:54722843C>T	uc001cxe.2	-	7	762	c.464G>A	c.(463-465)CGA>CAA	p.R155Q	SSBP3_uc001cxf.2_Intron|SSBP3_uc001cxg.2_Missense_Mutation_p.R128Q	NM_145716	NP_663768	Q9BWW4	SSBP3_HUMAN	single stranded DNA binding protein 3 isoform a	155	Pro-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	single-stranded DNA binding				0						GCCTGCGTATCGCGGTGACAT	0.522		NA											7	21					0	0	0	0
DAB1	1600	broad.mit.edu	37	1	57610988	57610988	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:57610988C>T	uc001cys.1	-	5	856	c.182G>A	c.(181-183)TGT>TAT	p.C61Y	DAB1_uc001cyt.1_Missense_Mutation_p.C61Y|DAB1_uc001cyq.1_Missense_Mutation_p.C61Y|DAB1_uc001cyr.1_Missense_Mutation_p.C61Y|DAB1_uc009vzw.1_Missense_Mutation_p.C61Y|DAB1_uc009vzx.1_Missense_Mutation_p.C61Y	NM_021080	NP_066566	O75553	DAB1_HUMAN	disabled homolog 1	61	PID.				cell differentiation|nervous system development					skin(2)|ovary(1)	3						GGAATCTTGACATAACTTGTC	0.393		NA											15	65					0	0	0	0
IL12RB2	3595	broad.mit.edu	37	1	67861293	67861294	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:67861293_67861294CC>AA	uc001ddu.2	+	16	2750_2751	c.2110_2111CC>AA	c.(2110-2112)CCG>AAG	p.P704K	IL12RB2_uc010oqi.1_3'UTR|IL12RB2_uc010oqj.1_3'UTR|IL12RB2_uc010oqk.1_RNA|IL12RB2_uc010oql.1_Missense_Mutation_p.P618K|IL12RB2_uc010oqm.1_3'UTR|IL12RB2_uc010oqn.1_RNA	NM_001559	NP_001550	Q99665	I12R2_HUMAN	interleukin 12 receptor, beta 2 precursor	704	Cytoplasmic (Potential).				positive regulation of cell proliferation|positive regulation of interferon-gamma production	integral to plasma membrane	cytokine receptor activity			ovary(2)|central_nervous_system(1)	3						AGATCCTGAACCGCTGGTCATC	0.54		NA											17	60					0	0	0	0
IFI44L	10964	broad.mit.edu	37	1	79093945	79093945	+	Silent	SNP	T	T	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:79093945T>C	uc010oro.1	+	2	524	c.345T>C	c.(343-345)CGT>CGC	p.R115R	IFI44L_uc010orp.1_Intron|IFI44L_uc010orq.1_Intron	NM_006820	NP_006811	Q53G44	IF44L_HUMAN	interferon-induced protein 44-like	115						cytoplasm					0						TGGTGTGTCGTTTATCGAAAA	0.313		NA											8	26					0	0	0	0
ELTD1	64123	broad.mit.edu	37	1	79385874	79385874	+	Silent	SNP	A	A	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:79385874A>T	uc001diq.3	-	10	1611	c.1455T>A	c.(1453-1455)ACT>ACA	p.T485T		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	485	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		ATACCTTATTAGTATTTGTAT	0.313		NA											10	18					0	0	0	0
COL24A1	255631	broad.mit.edu	37	1	86210435	86210435	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:86210435T>C	uc001dlj.2	-	57	4628	c.4586A>G	c.(4585-4587)CAC>CGC	p.H1529R	COL24A1_uc001dli.2_Missense_Mutation_p.H644R|COL24A1_uc010osd.1_Missense_Mutation_p.H829R|COL24A1_uc001dlk.2_RNA|COL24A1_uc010ose.1_RNA|COL24A1_uc010osf.1_RNA	NM_152890	NP_690850	Q17RW2	COOA1_HUMAN	collagen, type XXIV, alpha 1 precursor	1529	Fibrillar collagen NC1.				cell adhesion	collagen	extracellular matrix structural constituent			ovary(3)|central_nervous_system(1)|skin(1)	5				all cancers(265;0.0627)|Epithelial(280;0.0689)		CTTGATGCTGTGCAATAAATT	0.388		NA											23	63					0	0	0	0
PKN2	5586	broad.mit.edu	37	1	89271325	89271325	+	Silent	SNP	A	A	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:89271325A>T	uc001dmn.2	+	11	1989	c.1647A>T	c.(1645-1647)GTA>GTT	p.V549V	PKN2_uc001dmm.1_Silent_p.V549V|PKN2_uc010osp.1_Silent_p.V533V|PKN2_uc010osq.1_Silent_p.V392V|PKN2_uc009wcv.2_Silent_p.V501V|PKN2_uc010osr.1_Silent_p.V214V	NM_006256	NP_006247	Q16513	PKN2_HUMAN	protein kinase N2	549					signal transduction	cytoplasm	ATP binding|histone deacetylase binding|protein kinase C activity			large_intestine(1)|lung(1)|skin(1)	3		Lung NSC(277;0.123)		all cancers(265;0.0136)|Epithelial(280;0.0301)		TGGTTGATGTACGCATCCCTC	0.448		NA											5	32					0	0	0	0
ABCD3	5825	broad.mit.edu	37	1	94964203	94964203	+	Nonsense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:94964203G>T	uc001dqn.3	+	17	1534	c.1432G>T	c.(1432-1434)GGA>TGA	p.G478*	ABCD3_uc010oto.1_Nonsense_Mutation_p.G502*|ABCD3_uc010otp.1_Nonsense_Mutation_p.G405*|ABCD3_uc009wdr.2_Nonsense_Mutation_p.G368*|ABCD3_uc001dqo.3_Nonsense_Mutation_p.G166*	NM_002858	NP_002849	P28288	ABCD3_HUMAN	ATP-binding cassette, sub-family D, member 3	478	ATP (Potential).|ABC transporter.			G->R: Decreased ATP-binding affinity.	peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(1)	1		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		AAATGGCTGCGGAAAGAGTTC	0.343		NA											11	43					5.51e-06	6.36e-06	1	0
OLFM3	118427	broad.mit.edu	37	1	102290738	102290738	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:102290738C>A	uc001duf.2	-	4	567	c.496G>T	c.(496-498)GAT>TAT	p.D166Y	OLFM3_uc001dug.2_Missense_Mutation_p.D146Y|OLFM3_uc001duh.2_RNA|OLFM3_uc001dui.2_RNA|OLFM3_uc001duj.2_Missense_Mutation_p.D71Y|OLFM3_uc001due.2_RNA	NM_058170	NP_477518	Q96PB7	NOE3_HUMAN	olfactomedin 3	166	Potential.					extracellular region				ovary(2)|skin(1)	3		all_epithelial(167;1.87e-06)|all_lung(203;8.12e-05)|Lung NSC(277;0.000189)		all cancers(265;0.0843)|Epithelial(280;0.0921)|COAD - Colon adenocarcinoma(174;0.145)		AACTTAGCATCTGTTTTGTAC	0.448		NA											10	35					1.59e-06	1.87e-06	1	0
COL11A1	1301	broad.mit.edu	37	1	103354181	103354182	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:103354181_103354182GG>TT	uc001dul.2	-	62	4877_4878	c.4559_4560CC>AA	c.(4558-4560)CCC>CAA	p.P1520Q	COL11A1_uc001duk.2_Missense_Mutation_p.P716Q|COL11A1_uc001dum.2_Missense_Mutation_p.P1532Q|COL11A1_uc001dun.2_Missense_Mutation_p.P1481Q|COL11A1_uc009weh.2_Missense_Mutation_p.P1404Q	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	1520	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		TCTGGCCAGCGGGTCCCTGTTA	0.416		NA											8	36					0	0	0	0
COL11A1	1301	broad.mit.edu	37	1	103468025	103468025	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:103468025C>G	uc001dul.2	-	23	2374	c.2056G>C	c.(2056-2058)GAG>CAG	p.E686Q	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.E698Q|COL11A1_uc001dun.2_Missense_Mutation_p.E647Q|COL11A1_uc009weh.2_Missense_Mutation_p.E570Q	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	686	Triple-helical region.				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		GGCCCAGGCTCCCCTTGGGGA	0.438		NA											4	8					0	0	0	0
DDX20	11218	broad.mit.edu	37	1	112305593	112305593	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:112305593G>C	uc001ebs.2	+	10	1633	c.1276G>C	c.(1276-1278)GCC>CCC	p.A426P	DDX20_uc010owf.1_Missense_Mutation_p.A188P|DDX20_uc001ebt.2_Missense_Mutation_p.A34P	NM_007204	NP_009135	Q9UHI6	DDX20_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	426	Helicase C-terminal.				assembly of spliceosomal tri-snRNP|ncRNA metabolic process	Cajal body|cytoskeleton|cytosol|spliceosomal complex	ATP binding|ATP-dependent RNA helicase activity|DNA binding|protein binding			lung(1)|kidney(1)	2		all_cancers(81;1.06e-05)|all_epithelial(167;7.36e-06)|all_lung(203;2.44e-05)|Lung NSC(69;4.15e-05)		Lung(183;0.0234)|Colorectal(144;0.0282)|all cancers(265;0.0614)|Epithelial(280;0.0999)|COAD - Colon adenocarcinoma(174;0.111)|LUSC - Lung squamous cell carcinoma(189;0.133)		GATGAGAATTGCCCAGAAATG	0.353		NA											18	37					0	0	0	0
LASS2	29956	broad.mit.edu	37	1	150938997	150938997	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:150938997C>G	uc001evy.2	-	10	1344	c.957G>C	c.(955-957)TGG>TGC	p.W319C	LASS2_uc001evz.2_Missense_Mutation_p.W319C|LASS2_uc009wmh.2_Missense_Mutation_p.W169C	NM_181746	NP_859530	Q96G23	CERS2_HUMAN	LAG1 longevity assurance 2	319	TLC.|Helical; (Potential).					endoplasmic reticulum membrane|integral to membrane|nuclear membrane	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|sphingosine N-acyltransferase activity				0	all_lung(15;8.07e-35)|Lung NSC(24;7.93e-31)|Lung SC(34;0.00202)|Ovarian(49;0.0167)|all_hematologic(923;0.0597)|Hepatocellular(266;0.0997)|Melanoma(130;0.185)		UCEC - Uterine corpus endometrioid carcinoma (35;0.0486)|LUSC - Lung squamous cell carcinoma(543;0.211)			TGAGGTAGGCCCAGAAGATAT	0.478		NA											17	57					0	0	0	0
IVL	3713	broad.mit.edu	37	1	152883955	152883955	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:152883955C>G	uc001fau.2	+	2	1728	c.1682C>G	c.(1681-1683)ACA>AGA	p.T561R		NM_005547	NP_005538	P07476	INVO_HUMAN	involucrin	561					isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine|keratinization|response to UV-B	cornified envelope|cytoplasm	protein binding, bridging|structural molecule activity			ovary(3)	3	Lung NSC(65;3.97e-29)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			GCCCTGCCCACAAAGGGAGAA	0.438		NA											16	59					0	0	0	0
DENND4B	9909	broad.mit.edu	37	1	153914360	153914360	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:153914360C>G	uc001fdd.1	-	6	1441	c.1040G>C	c.(1039-1041)CGC>CCC	p.R347P		NM_014856	NP_055671	O75064	DEN4B_HUMAN	DENN/MADD domain containing 4B	347	DENN.									ovary(1)	1	all_lung(78;2.89e-32)|Lung NSC(65;2.27e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			CAAGGGTAGGCGGTGGGGGCC	0.632		NA											11	51					0	0	0	0
FCRL3	115352	broad.mit.edu	37	1	157659664	157659664	+	Silent	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:157659664C>T	uc001frb.2	-	10	2026	c.1734G>A	c.(1732-1734)ACG>ACA	p.T578T	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Silent_p.T578T|FCRL3_uc009wsn.2_RNA|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_Silent_p.T304T|FCRL3_uc001frc.1_Silent_p.T578T	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	578	Helical; (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)					GCACCAGCCCCGTGATTCCCG	0.562		NA											15	40					0	0	0	0
UAP1	6675	broad.mit.edu	37	1	162557316	162557316	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:162557316G>A	uc001gce.3	+	6	1215	c.886G>A	c.(886-888)GAT>AAT	p.D296N		NM_003115	NP_003106	Q16222	UAP1_HUMAN	UDP-N-acetylglucosamine pyrophosphorylase 1	296					dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|UDP-N-acetylglucosamine biosynthetic process	cytosol|nucleus|plasma membrane	UDP-N-acetylglucosamine diphosphorylase activity			ovary(2)|skin(2)|kidney(1)	5	all_hematologic(112;0.115)		BRCA - Breast invasive adenocarcinoma(70;0.126)			TTGCCGAGTGGATGGAGTTTA	0.463		NA											29	99					0	0	0	0
NUF2	83540	broad.mit.edu	37	1	163317627	163317627	+	Silent	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:163317627C>T	uc001gcq.1	+	12	1323	c.1023C>T	c.(1021-1023)TTC>TTT	p.F341F	NUF2_uc001gcr.1_Silent_p.F341F|NUF2_uc009wvc.1_Silent_p.F294F	NM_145697	NP_663735	Q9BZD4	NUF2_HUMAN	NUF2, NDC80 kinetochore complex component	341	Interaction with the N-terminus of NDC80.|Potential.				cell division|chromosome segregation|mitotic prometaphase	condensed chromosome kinetochore|cytosol|Ndc80 complex|nucleus	protein binding			ovary(3)|skin(1)	4	all_hematologic(923;0.101)					AAAATTCGTTCAAAAGACTGA	0.338		NA											14	46					0	0	0	0
PAPPA2	60676	broad.mit.edu	37	1	176671756	176671756	+	Nonsense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:176671756G>T	uc001gkz.2	+	9	4414	c.3250G>T	c.(3250-3252)GGA>TGA	p.G1084*	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1084					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						GGTCACACCTGGACAGATGTA	0.502		NA											13	35					4.38e-07	5.22e-07	1	0
PAPPA2	60676	broad.mit.edu	37	1	176675542	176675542	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:176675542G>C	uc001gkz.2	+	10	4577	c.3413G>C	c.(3412-3414)GGC>GCC	p.G1138A	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1138					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						AGCGGAGATGGCTGCTCCAAG	0.403		NA											6	33					0	0	0	0
PAPPA2	60676	broad.mit.edu	37	1	176709164	176709164	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:176709164C>G	uc001gkz.2	+	14	5147	c.3983C>G	c.(3982-3984)ACC>AGC	p.T1328S	PAPPA2_uc009www.2_RNA	NM_020318	NP_064714	Q9BXP8	PAPP2_HUMAN	pappalysin 2 isoform 1	1328					cell differentiation|proteolysis|regulation of cell growth	extracellular region|intracellular|membrane	metalloendopeptidase activity|zinc ion binding			ovary(7)|central_nervous_system(5)|skin(2)|lung(1)|breast(1)	16						ATCAATGTGACCCATCACCAG	0.463		NA											22	81					0	0	0	0
CEP350	9857	broad.mit.edu	37	1	180034395	180034395	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:180034395G>T	uc001gnt.2	+	27	5938	c.5555G>T	c.(5554-5556)CGC>CTC	p.R1852L	CEP350_uc009wxl.2_Missense_Mutation_p.R1851L	NM_014810	NP_055625	Q5VT06	CE350_HUMAN	centrosome-associated protein 350	1852						centrosome|nucleus|spindle				ovary(4)	4						ATGAGAAGCCGCATGGATGAA	0.358		NA											7	19					0.000157383	0.000175665	1	0
HMCN1	83872	broad.mit.edu	37	1	186060049	186060049	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:186060049G>T	uc001grq.1	+	64	10116	c.9887G>T	c.(9886-9888)CGA>CTA	p.R3296L		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	3296	Ig-like C2-type 31.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GAAAGAATCCGGTATGTTTAA	0.353		NA											9	30					3.1e-07	3.7e-07	1	0
HMCN1	83872	broad.mit.edu	37	1	186094925	186094925	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:186094925T>C	uc001grq.1	+	82	12918	c.12689T>C	c.(12688-12690)GTG>GCG	p.V4230A	HMCN1_uc001grs.1_5'Flank	NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	4230	Ig-like C2-type 41.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GAAAATGTTGTGGTAAGTTTA	0.303		NA											16	21					0	0	0	0
CFH	3075	broad.mit.edu	37	1	196697650	196697650	+	Nonsense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:196697650C>A	uc001gtj.3	+	15	2651	c.2411C>A	c.(2410-2412)TCA>TAA	p.S804*		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	804	Sushi 13.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						GTGAACTGCTCAAGTAAGCTC	0.318		NA											16	40					1.34e-09	1.69e-09	1	0
CFH	3075	broad.mit.edu	37	1	196709852	196709852	+	Silent	SNP	T	T	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:196709852T>A	uc001gtj.3	+	18	3126	c.2886T>A	c.(2884-2886)GGT>GGA	p.G962G		NM_000186	NP_000177	P08603	CFAH_HUMAN	complement factor H isoform a precursor	962	Sushi 16.				complement activation, alternative pathway	extracellular space				skin(4)|ovary(1)|breast(1)	6						GTTTTGAAGGTTTTGGAATTG	0.373		NA											34	65					0	0	0	0
MYBPH	4608	broad.mit.edu	37	1	203140617	203140617	+	Silent	SNP	G	G	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:203140617G>C	uc001gzh.1	-	5	746	c.687C>G	c.(685-687)TCC>TCG	p.S229S	FMOD_uc010pqi.1_Intron	NM_004997	NP_004988	Q13203	MYBPH_HUMAN	myosin binding protein H	229	Ig-like C2-type 1.				cell adhesion|regulation of striated muscle contraction	myosin filament	structural constituent of muscle				0			BRCA - Breast invasive adenocarcinoma(75;0.153)	Colorectal(1306;0.0306)		TGAAGAGGATGGAGTCCTGGT	0.652		NA											14	41					0	0	0	0
PROX1	5629	broad.mit.edu	37	1	214170722	214170722	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:214170722G>A	uc001hkh.2	+	2	1116	c.844G>A	c.(844-846)GAG>AAG	p.E282K	PROX1_uc001hkg.1_Missense_Mutation_p.E282K	NM_002763	NP_002754	Q92786	PROX1_HUMAN	prospero homeobox 1	282					aorta smooth muscle tissue morphogenesis|atrial cardiac muscle tissue morphogenesis|brain development|dorsal spinal cord development|embryonic retina morphogenesis in camera-type eye|endocardium formation|hepatocyte differentiation|kidney development|lens fiber cell morphogenesis|lung development|lymphangiogenesis|negative regulation of bile acid biosynthetic process|negative regulation of cell proliferation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of viral genome replication|neural tube development|olfactory placode formation|optic placode formation involved in camera-type eye formation|otic placode formation|pancreas development|positive regulation of cyclin-dependent protein kinase activity|positive regulation of endothelial cell migration|positive regulation of endothelial cell proliferation|positive regulation of heart growth|positive regulation of S phase of mitotic cell cycle|positive regulation of sarcomere organization|positive regulation of transcription, DNA-dependent|regulation of transcription involved in lymphatic endothelial cell fate commitment|skeletal muscle thin filament assembly|venous blood vessel morphogenesis|ventricular cardiac muscle tissue morphogenesis|ventricular cardiac myofibril development|ventricular septum morphogenesis	cytoplasm|nucleus	DBD domain binding|LBD domain binding|ligand-dependent nuclear receptor binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|transcription corepressor activity|transcription regulatory region DNA binding			ovary(3)|lung(1)|central_nervous_system(1)|skin(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0179)|all cancers(67;0.0488)|GBM - Glioblastoma multiforme(131;0.188)|Epithelial(68;0.219)		CATGCGCTCGGAGATCCTGGA	0.517		NA											21	63					0	0	0	0
SLC35F3	148641	broad.mit.edu	37	1	234444872	234444872	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:234444872A>T	uc001hwa.1	+	3	655	c.427A>T	c.(427-429)AAT>TAT	p.N143Y	SLC35F3_uc001hvy.1_Missense_Mutation_p.N212Y	NM_173508	NP_775779	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	143					transport	integral to membrane				ovary(2)	2	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			TTTTGGAGACAATGGCTTGAC	0.378		NA											26	91					0	0	0	0
SLC35F3	148641	broad.mit.edu	37	1	234444975	234444975	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:234444975C>A	uc001hwa.1	+	3	758	c.530C>A	c.(529-531)ACT>AAT	p.T177N	SLC35F3_uc001hvy.1_Missense_Mutation_p.T246N	NM_173508	NP_775779	Q8IY50	S35F3_HUMAN	solute carrier family 35, member F3	177					transport	integral to membrane				ovary(2)	2	Ovarian(103;0.0454)	all_cancers(173;0.145)|Prostate(94;0.0885)	OV - Ovarian serous cystadenocarcinoma(106;0.00531)			AAAATAAACACTACGGATGTC	0.438		NA											30	90					3.73e-12	4.87e-12	1	0
RYR2	6262	broad.mit.edu	37	1	237923109	237923109	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:237923109G>T	uc001hyl.1	+	83	11479	c.11359G>T	c.(11359-11361)GTG>TTG	p.V3787L	RYR2_uc010pya.1_Missense_Mutation_p.V202L	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3787					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GAAAAAGGATGTGGGCTTCTT	0.413		NA											17	62					4.97e-08	6.04e-08	1	0
FMN2	56776	broad.mit.edu	37	1	240351556	240351556	+	Silent	SNP	C	C	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:240351556C>G	uc010pyd.1	+	4	2205	c.1980C>G	c.(1978-1980)GTC>GTG	p.V660V	FMN2_uc010pye.1_Silent_p.V664V	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	660					actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			CAGATGCTGTCCAGAAGGTAA	0.408		NA											13	66					0	0	0	0
RGS7	6000	broad.mit.edu	37	1	240976951	240976951	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:240976951G>T	uc001hyv.2	-	13	1253	c.923C>A	c.(922-924)TCC>TAC	p.S308Y	RGS7_uc010pyh.1_Missense_Mutation_p.S282Y|RGS7_uc010pyj.1_Missense_Mutation_p.S224Y|RGS7_uc001hyu.2_Missense_Mutation_p.S308Y|RGS7_uc009xgn.1_Missense_Mutation_p.S255Y|RGS7_uc001hyw.2_Missense_Mutation_p.S308Y|RGS7_uc001hyt.2_Missense_Mutation_p.S140Y	NM_002924	NP_002915	P49802	RGS7_HUMAN	regulator of G-protein signaling 7	308	G protein gamma.				G-protein coupled receptor protein signaling pathway|intracellular signal transduction|negative regulation of signal transduction|regulation of G-protein coupled receptor protein signaling pathway	cytoplasm|heterotrimeric G-protein complex	GTPase activator activity|protein binding|signal transducer activity			ovary(4)|skin(2)|kidney(1)	7		all_cancers(173;0.0131)	OV - Ovarian serous cystadenocarcinoma(106;0.027)			GGTGTCATCGGACAGCCATGG	0.443		NA											5	22					1.64e-10	2.09e-10	1	0
OR13G1	441933	broad.mit.edu	37	1	247835845	247835845	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:247835845C>A	uc001idi.1	-	1	499	c.499G>T	c.(499-501)GGG>TGG	p.G167W		NM_001005487	NP_001005487	Q8NGZ3	O13G1_HUMAN	olfactory receptor, family 13, subfamily G,	167	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1	all_cancers(71;3.24e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)		OV - Ovarian serous cystadenocarcinoma(106;0.017)			GTGTTTGGCCCACAGAAAGTC	0.483		NA											15	38					0.000308642	0.000340199	1	0
OR2T6	254879	broad.mit.edu	37	1	248551061	248551061	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:248551061T>C	uc001iei.1	+	1	152	c.152T>C	c.(151-153)ATA>ACA	p.I51T		NM_001005471	NP_001005471	Q8NHC8	OR2T6_HUMAN	olfactory receptor, family 2, subfamily T,	51	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CTGATTAACATAGACCCTCAT	0.458		NA											9	31					0	0	0	0
OR2G6	391211	broad.mit.edu	37	1	248685492	248685492	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:248685492C>T	uc001ien.1	+	1	545	c.545C>T	c.(544-546)CCA>CTA	p.P182L		NM_001013355	NP_001013373	Q5TZ20	OR2G6_HUMAN	olfactory receptor, family 2, subfamily G,	182	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(1)	3	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)	all_cancers(173;0.0156)	OV - Ovarian serous cystadenocarcinoma(106;0.0265)			TGTGAGGTGCCAGTGCTCATC	0.512		NA											12	45					0	0	0	0
FAM188A	80013	broad.mit.edu	37	10	15838171	15838171	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr10:15838171C>A	uc001iod.1	-	11	1104	c.883G>T	c.(883-885)GAT>TAT	p.D295Y	FAM188A_uc001ioe.1_Missense_Mutation_p.D122Y|FAM188A_uc001iof.1_Missense_Mutation_p.D295Y	NM_024948	NP_079224	Q9H8M7	F188A_HUMAN	chromosome 10 open reading frame 97	295					apoptosis	nucleus	calcium ion binding			ovary(1)	1						AAAGCCATATCCTGAAAAGAT	0.353		NA											32	98					2.68e-12	3.51e-12	1	0
CUBN	8029	broad.mit.edu	37	10	16982125	16982125	+	Silent	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr10:16982125G>A	uc001ioo.2	-	37	5506	c.5454C>T	c.(5452-5454)CTC>CTT	p.L1818L		NM_001081	NP_001072	O60494	CUBN_HUMAN	cubilin precursor	1818	CUB 12.				cholesterol metabolic process|cobalamin transport|hormone biosynthetic process|lipoprotein metabolic process|receptor-mediated endocytosis|tissue homeostasis|vitamin D metabolic process	brush border membrane|cytosol|endosome membrane|extrinsic to external side of plasma membrane|lysosomal lumen|lysosomal membrane	calcium ion binding|cobalamin binding|protein homodimerization activity|receptor activity|transporter activity			ovary(9)|breast(4)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|kidney(1)	19					Cyanocobalamin(DB00115)|Hydroxocobalamin(DB00200)	AAGAATAATTGAGAGGGAAGG	0.498		NA											109	149					0	0	0	0
FRMPD2	143162	broad.mit.edu	37	10	49444559	49444559	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr10:49444559G>T	uc001jgi.2	-	9	1066	c.959C>A	c.(958-960)GCC>GAC	p.A320D	FRMPD2_uc001jgh.2_Missense_Mutation_p.A289D|FRMPD2_uc001jgj.2_Missense_Mutation_p.A298D	NM_001018071	NP_001018081	Q68DX3	FRPD2_HUMAN	FERM and PDZ domain containing 2 isoform 3	320					tight junction assembly	basolateral plasma membrane|cytoplasm|cytoskeleton|tight junction	1-phosphatidylinositol binding|protein binding			large_intestine(1)	1				Kidney(211;0.201)		TGTCATCGGGGCCTCTCCAGC	0.567		NA											20	60					1.11e-12	1.46e-12	1	0
CHAT	1103	broad.mit.edu	37	10	50872936	50872936	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr10:50872936C>A	uc001jhz.2	+	15	2244	c.2091C>A	c.(2089-2091)CAC>CAA	p.H697Q	CHAT_uc001jhv.1_Missense_Mutation_p.H579Q|CHAT_uc001jhx.1_Missense_Mutation_p.H579Q|CHAT_uc001jhy.1_Missense_Mutation_p.H579Q|CHAT_uc001jia.2_Missense_Mutation_p.H579Q|CHAT_uc010qgs.1_Intron	NM_020549	NP_065574	P28329	CLAT_HUMAN	choline acetyltransferase isoform 2	697					neurotransmitter biosynthetic process|neurotransmitter secretion	cytosol|nucleus	choline O-acetyltransferase activity			central_nervous_system(3)	3		all_neural(218;0.107)		GBM - Glioblastoma multiforme(2;0.000585)	Choline(DB00122)	CTAGCTTTCACAGCTGCAAAG	0.512		NA											53	208					4.88e-21	6.92e-21	1	0
ZNF365	22891	broad.mit.edu	37	10	64415348	64415348	+	Silent	SNP	C	C	G	rs150729144		TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr10:64415348C>G	uc001jmd.1	+	4	682	c.348C>G	c.(346-348)TCC>TCG	p.S116S	ZNF365_uc001jmc.2_Intron|ZNF365_uc001jme.1_Intron|ZNF365_uc001jmf.1_Intron|ZNF365_uc009xpg.1_Intron	NM_199452	NP_955524	Q70YC4	TALAN_HUMAN	zinc finger protein 365 isoform D	116										ovary(1)|skin(1)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)					GTGGTCTCTCCGAGCTCATCA	0.502		NA											22	82					0	0	0	0
KCNMA1	3778	broad.mit.edu	37	10	78651359	78651359	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr10:78651359G>A	uc001jxn.2	-	26	3443	c.3266C>T	c.(3265-3267)CCG>CTG	p.P1089L	KCNMA1_uc001jxj.2_Missense_Mutation_p.P1035L|KCNMA1_uc001jxk.1_Missense_Mutation_p.P707L|KCNMA1_uc009xrt.1_Missense_Mutation_p.P880L|KCNMA1_uc001jxl.1_Missense_Mutation_p.P714L|KCNMA1_uc001jxo.2_Missense_Mutation_p.P1072L|KCNMA1_uc001jxm.2_Missense_Mutation_p.P1031L|KCNMA1_uc001jxq.2_Missense_Mutation_p.P1061L|uc001jxp.2_Intron	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	1089	Cytoplasmic (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	CAGTGTCTGCGGGGTGCTGTA	0.627		NA											16	36					0	0	0	0
KCNMA1	3778	broad.mit.edu	37	10	78846265	78846265	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr10:78846265T>C	uc001jxn.2	-	11	1598	c.1421A>G	c.(1420-1422)CAT>CGT	p.H474R	KCNMA1_uc001jxj.2_Missense_Mutation_p.H474R|KCNMA1_uc001jxk.1_Missense_Mutation_p.H89R|KCNMA1_uc009xrt.1_Missense_Mutation_p.H294R|KCNMA1_uc001jxl.1_Missense_Mutation_p.H128R|KCNMA1_uc001jxo.2_Missense_Mutation_p.H474R|KCNMA1_uc001jxm.2_Missense_Mutation_p.H474R|KCNMA1_uc001jxq.2_Missense_Mutation_p.H474R	NM_001161352	NP_001154824	Q12791	KCMA1_HUMAN	large conductance calcium-activated potassium	474	RCK N-terminal.|Cytoplasmic (Potential).				cellular potassium ion homeostasis|negative regulation of cell volume|platelet activation|positive regulation of apoptosis|regulation of membrane potential|response to calcium ion|response to carbon monoxide|response to hypoxia|response to osmotic stress|smooth muscle contraction involved in micturition	apical plasma membrane|caveola|integral to membrane|voltage-gated potassium channel complex	actin binding|calcium-activated potassium channel activity|large conductance calcium-activated potassium channel activity|metal ion binding|voltage-gated potassium channel activity			pancreas(2)|ovary(1)	3	all_cancers(46;0.203)|all_epithelial(25;0.00604)|Prostate(51;0.0198)		OV - Ovarian serous cystadenocarcinoma(4;0.0586)|Epithelial(14;0.081)|all cancers(16;0.183)		Bendroflumethiazide(DB00436)|Benzthiazide(DB00562)|Chlorothiazide(DB00880)|Chlorzoxazone(DB00356)|Cromoglicate(DB01003)|Cyclothiazide(DB00606)|Diazoxide(DB01119)|Enflurane(DB00228)|Hydrochlorothiazide(DB00999)|Hydroflumethiazide(DB00774)|Methyclothiazide(DB00232)|Quinethazone(DB01325)|Trichlormethiazide(DB01021)	TGCAAGATCATGTGGATTGAG	0.502		NA											21	44					0	0	0	0
SFTPA2	729238	broad.mit.edu	37	10	81317057	81317057	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr10:81317057G>A	uc001kal.3	-	6	752	c.655C>T	c.(655-657)CGG>TGG	p.R219W	SFTPA2_uc001kan.3_Missense_Mutation_p.R219W	NM_006926	NP_008857	Q8IWL1	SFPA2_HUMAN	RecName: Full=Pulmonary surfactant-associated protein A2;          Short=SP-A2;          Short=SP-A;          Short=PSP-A;          Short=PSPA; AltName: Full=Alveolar proteinosis protein; AltName: Full=35 kDa pulmonary surfactant-associated protein; Flags: Precursor;	219	C-type lectin.				cell junction assembly|respiratory gaseous exchange	collagen|extracellular space	sugar binding				0	all_cancers(46;0.197)|Breast(12;0.000326)|Prostate(51;0.00985)|all_epithelial(25;0.0149)		Epithelial(14;0.00957)|all cancers(16;0.0179)|Colorectal(32;0.229)			TCTTTTCCCCGACCTGCAGGC	0.557		NA							Pulmonary_Fibrosis_Idiopathic				40	319					0	0	0	0
KIF20B	9585	broad.mit.edu	37	10	91528644	91528644	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr10:91528644A>T	uc001kgs.1	+	31	5313	c.5241A>T	c.(5239-5241)AAA>AAT	p.K1747N	KIF20B_uc001kgr.1_Missense_Mutation_p.K1707N|KIF20B_uc001kgt.1_Missense_Mutation_p.K958N|KIF20B_uc009xtw.1_RNA	NM_016195	NP_057279	Q96Q89	KI20B_HUMAN	M-phase phosphoprotein 1	1747	Interaction with PIN1.				cell cycle arrest|cell division|microtubule-based movement|mitosis|regulation of mitosis	centrosome|microtubule|nucleolus|nucleoplasm|spindle	ATP binding|ATPase activity|microtubule motor activity|WW domain binding			ovary(1)|pancreas(1)|skin(1)	3						TTCAATCAAAAGGTTTGCAGA	0.313		NA											8	29					0	0	0	0
HECTD2	143279	broad.mit.edu	37	10	93221100	93221100	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr10:93221100A>T	uc001khl.2	+	4	597	c.497A>T	c.(496-498)AAT>ATT	p.N166I	LOC100188947_uc010qnl.1_Intron|HECTD2_uc001khk.2_Missense_Mutation_p.N166I|HECTD2_uc010qnm.1_Missense_Mutation_p.N166I|HECTD2_uc001khm.2_RNA|HECTD2_uc009xty.1_5'Flank	NM_182765	NP_877497	Q5U5R9	HECD2_HUMAN	HECT domain containing 2 isoform a	166					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	ubiquitin-protein ligase activity			skin(1)	1						CCAGAATTAAATGCTGCATTT	0.274		NA											23	67					0	0	0	0
EXOC6	54536	broad.mit.edu	37	10	94773979	94773979	+	Silent	SNP	A	A	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr10:94773979A>G	uc001kig.2	+	20	2190	c.2124A>G	c.(2122-2124)GGA>GGG	p.G708G	EXOC6_uc010qnr.1_Silent_p.G724G|EXOC6_uc001kie.2_Silent_p.G703G|EXOC6_uc009xub.2_Silent_p.G707G|EXOC6_uc009xuc.2_Silent_p.G605G|EXOC6_uc001kih.2_RNA|EXOC6_uc001kii.2_Silent_p.G282G	NM_019053	NP_061926	Q8TAG9	EXOC6_HUMAN	SEC15-like 1 isoform a	708					protein transport|vesicle docking involved in exocytosis	exocyst				skin(1)	1		Colorectal(252;0.123)				CTGTGCCAGGATTCCAGGGGG	0.378		NA											15	47					0	0	0	0
ALDH18A1	5832	broad.mit.edu	37	10	97402775	97402775	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr10:97402775C>A	uc001kkz.2	-	3	519	c.277G>T	c.(277-279)GGG>TGG	p.G93W	ALDH18A1_uc001kky.2_Missense_Mutation_p.G93W|ALDH18A1_uc010qog.1_Intron|ALDH18A1_uc010qoh.1_Intron	NM_002860	NP_002851	P54886	P5CS_HUMAN	pyrroline-5-carboxylate synthetase isoform 1	93	Glutamate 5-kinase.				proline biosynthetic process	mitochondrial inner membrane	ATP binding|glutamate 5-kinase activity|glutamate-5-semialdehyde dehydrogenase activity			pancreas(1)|central_nervous_system(1)|skin(1)	3		Colorectal(252;0.0402)		Epithelial(162;9.1e-07)|all cancers(201;2.55e-05)	L-Glutamic Acid(DB00142)	GCCAAGCGCCCCAGGGCCAGG	0.507		NA											11	34					0.000673444	0.000734062	1	0
PNLIPRP1	5407	broad.mit.edu	37	10	118355782	118355782	+	Silent	SNP	C	C	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr10:118355782C>G	uc001lco.1	+	6	540	c.522C>G	c.(520-522)GCC>GCG	p.A174A	PNLIPRP1_uc001lcp.2_Silent_p.A174A|PNLIPRP1_uc009xys.1_RNA	NM_006229	NP_006220	P54315	LIPR1_HUMAN	pancreatic lipase-related protein 1 precursor	174					lipid metabolic process		calcium ion binding|triglyceride lipase activity			ovary(1)|breast(1)	2				all cancers(201;0.0161)		GCCTGGGAGCCCACGTGGCTG	0.537		NA											37	156					0	0	0	0
MRGPRX4	117196	broad.mit.edu	37	11	18195351	18195351	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr11:18195351G>C	uc001mnv.1	+	1	968	c.548G>C	c.(547-549)TGG>TCG	p.W183S		NM_054032	NP_473373	Q96LA9	MRGX4_HUMAN	MAS-related GPR, member X4	183	Helical; Name=5; (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			skin(1)	1						CCAGTCGCGTGGCTGATTTTT	0.512		NA											77	68					0	0	0	0
SYT13	57586	broad.mit.edu	37	11	45277359	45277359	+	Silent	SNP	C	C	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr11:45277359C>G	uc001myq.2	-	2	393	c.267G>C	c.(265-267)GTG>GTC	p.V89V	SYT13_uc009yku.1_5'UTR	NM_020826	NP_065877	Q7L8C5	SYT13_HUMAN	synaptotagmin XIII	89	Cytoplasmic (Potential).					transport vesicle				ovary(1)	1						CTGGAGCCGTCACAGCTGGCC	0.547		NA											34	37					0	0	0	0
OR8J3	81168	broad.mit.edu	37	11	55904831	55904831	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr11:55904831G>A	uc010riz.1	-	1	364	c.364C>T	c.(364-366)CGC>TGC	p.R122C		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	122	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					GCCACATAGCGGTCATAGGCC	0.502		NA											25	53					0	0	0	0
MS4A14	84689	broad.mit.edu	37	11	60183406	60183406	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr11:60183406C>T	uc001npj.2	+	5	1530	c.965C>T	c.(964-966)TCC>TTC	p.S322F	MS4A14_uc001npi.2_Missense_Mutation_p.S210F|MS4A14_uc001npn.2_Missense_Mutation_p.S60F|MS4A14_uc001npk.2_Missense_Mutation_p.S305F|MS4A14_uc001npl.2_Missense_Mutation_p.S60F|MS4A14_uc001npm.2_Missense_Mutation_p.S60F	NM_032597	NP_115986	Q96JA4	M4A14_HUMAN	membrane-spanning 4-domains, subfamily A, member	322						integral to membrane	receptor activity			breast(1)	1						GACTTGCCATCCCAAGCTCTA	0.453		NA											12	19					0	0	0	0
MEN1	4221	broad.mit.edu	37	11	64577147	64577147	+	Silent	SNP	G	G	A	rs61736636	byFrequency	TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr11:64577147G>A	uc001obj.2	-	2	508	c.435C>T	c.(433-435)AGC>AGT	p.S145S	MEN1_uc001obk.2_Silent_p.S145S|MEN1_uc001obl.2_Silent_p.S145S|MEN1_uc001obm.2_Silent_p.S145S|MEN1_uc001obn.2_Silent_p.S145S|MEN1_uc001obo.2_Silent_p.S145S|MEN1_uc001obp.2_Silent_p.S145S|MEN1_uc001obq.2_Silent_p.S145S|MEN1_uc001obr.2_Silent_p.S145S	NM_130800	NP_570712	O00255	MEN1_HUMAN	menin isoform 1	145					DNA repair|histone lysine methylation|MAPKKK cascade|negative regulation of cell proliferation|negative regulation of cyclin-dependent protein kinase activity|negative regulation of JNK cascade|negative regulation of osteoblast differentiation|negative regulation of protein phosphorylation|negative regulation of sequence-specific DNA binding transcription factor activity|negative regulation of telomerase activity|negative regulation of transcription from RNA polymerase II promoter|osteoblast development|positive regulation of protein binding|positive regulation of transforming growth factor beta receptor signaling pathway|response to gamma radiation|response to UV|transcription, DNA-dependent	chromatin|cleavage furrow|cytosol|histone methyltransferase complex|nuclear matrix|soluble fraction	double-stranded DNA binding|four-way junction DNA binding|protein binding, bridging|protein N-terminus binding|R-SMAD binding|transcription regulatory region DNA binding|Y-form DNA binding	p.F146fs*34(1)|p.S145R(1)		parathyroid(105)|pancreas(64)|gastrointestinal_tract_(site_indeterminate)(15)|small_intestine(13)|lung(9)|pituitary(7)|NS(7)|adrenal_gland(5)|soft_tissue(4)|central_nervous_system(4)|thymus(2)|stomach(1)|retroperitoneum(1)|skin(1)	238						CTGTGATGAAGCTGAAGAGGG	0.498		NA	D|Mis|N|F|S		parathyroid tumors|Pancreatic neuroendocrine tumors	parathyroid adenoma|pituitary adenoma|pancreatic islet cell|carcinoid			Hyperparathyroidism_Familial_Isolated|Multiple_Endocrine_Neoplasia_type_1				6	143					0	0	0	0
PACS1	55690	broad.mit.edu	37	11	66008926	66008926	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr11:66008926A>G	uc001oha.1	+	22	2592	c.2458A>G	c.(2458-2460)ATT>GTT	p.I820V	PACS1_uc010rou.1_Missense_Mutation_p.I356V	NM_018026	NP_060496	Q6VY07	PACS1_HUMAN	phosphofurin acidic cluster sorting protein 1	820					interspecies interaction between organisms|regulation of defense response to virus by virus|viral reproduction	cytosol	protein binding			ovary(6)	6						TGGGGACGTGATTGGCCTCCA	0.592		NA											4	39					0	0	0	0
CPT1A	1374	broad.mit.edu	37	11	68548156	68548156	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr11:68548156G>T	uc001oog.3	-	12	1580	c.1410C>A	c.(1408-1410)AAC>AAA	p.N470K	CPT1A_uc001oof.3_Missense_Mutation_p.N470K|CPT1A_uc009ysj.2_Intron	NM_001876	NP_001867	P50416	CPT1A_HUMAN	carnitine palmitoyltransferase 1A liver isoform	470	Cytoplasmic (Potential).				carnitine shuttle|fatty acid beta-oxidation	integral to membrane|mitochondrial outer membrane	carnitine O-palmitoyltransferase activity			skin(2)	2	Esophageal squamous(3;3.28e-14)		LUAD - Lung adenocarcinoma(13;0.0676)|STAD - Stomach adenocarcinoma(18;0.142)		L-Carnitine(DB00583)|Perhexiline(DB01074)	AGTGTTCAGCGTTGAGGCCCA	0.463		NA											172	84					6.84e-98	9.91e-98	1	0
MRPL21	219927	broad.mit.edu	37	11	68665462	68665462	+	Silent	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr11:68665462G>T	uc001ooi.2	-	3	190	c.165C>A	c.(163-165)TCC>TCA	p.S55S	MRPL21_uc001ooh.2_5'UTR|MRPL21_uc010rqe.1_Silent_p.S55S	NM_181514	NP_852615	Q7Z2W9	RM21_HUMAN	mitochondrial ribosomal protein L21 isoform d	55					translation	mitochondrion|ribosome	RNA binding|structural constituent of ribosome				0			STAD - Stomach adenocarcinoma(18;0.0208)|LUAD - Lung adenocarcinoma(13;0.0713)			GTGAACTCAGGGATGTTTTAG	0.473		NA											74	197					5.77e-54	8.35e-54	1	0
AMOTL1	154810	broad.mit.edu	37	11	94533290	94533290	+	Nonsense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr11:94533290G>T	uc001pfb.2	+	3	1104	c.934G>T	c.(934-936)GAG>TAG	p.E312*	AMOTL1_uc001pfc.2_Nonsense_Mutation_p.E262*	NM_130847	NP_570899	Q8IY63	AMOL1_HUMAN	angiomotin like 1	312						cytoplasm|tight junction	identical protein binding			ovary(1)|breast(1)	2		Acute lymphoblastic leukemia(157;2.38e-05)|all_hematologic(158;0.00824)				TCCTCCACCTGAGTACCCCTT	0.602		NA											59	65					7.48e-22	1.07e-21	1	0
MMP8	4317	broad.mit.edu	37	11	102593338	102593338	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr11:102593338T>C	uc001phe.2	-	2	268	c.169A>G	c.(169-171)AAT>GAT	p.N57D	MMP8_uc010rut.1_5'UTR|MMP8_uc010ruu.1_Missense_Mutation_p.N34D	NM_002424	NP_002415	P22894	MMP8_HUMAN	matrix metalloproteinase 8 preproprotein	57					collagen catabolic process|proteolysis	extracellular space|proteinaceous extracellular matrix	metalloendopeptidase activity|serine-type endopeptidase activity|zinc ion binding			ovary(3)|breast(1)	4	all_cancers(8;0.00092)|all_epithelial(12;0.00389)|Lung NSC(15;0.227)	all_hematologic(158;0.00092)|Acute lymphoblastic leukemia(157;0.000967)	Epithelial(9;0.0555)|Lung(13;0.0828)|LUSC - Lung squamous cell carcinoma(19;0.151)|all cancers(10;0.189)	BRCA - Breast invasive adenocarcinoma(274;0.0141)		ACGATCACATTAGTGCCATTC	0.433		NA											27	32					0	0	0	0
CDON	50937	broad.mit.edu	37	11	125871614	125871614	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr11:125871614C>T	uc009zbw.2	-	11	2286	c.2158G>A	c.(2158-2160)GTT>ATT	p.V720I	CDON_uc001qdb.3_Missense_Mutation_p.V97I|CDON_uc001qdc.3_Missense_Mutation_p.V720I	NM_016952	NP_058648	Q4KMG0	CDON_HUMAN	surface glycoprotein, Ig superfamily member	720	Extracellular (Potential).				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|skin(2)|breast(1)	6	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		TTCTTTTTACCTCCACTGTGC	0.408		NA											13	27					0	0	0	0
ATN1	1822	broad.mit.edu	37	12	7047905	7047905	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr12:7047905G>T	uc001qrw.1	+	7	3016	c.2779G>T	c.(2779-2781)GAT>TAT	p.D927Y	ATN1_uc001qrx.1_Missense_Mutation_p.D927Y	NM_001007026	NP_001007027	P54259	ATN1_HUMAN	atrophin-1	927					cell death|central nervous system development	cytoplasm|nucleus	protein domain specific binding			ovary(2)|breast(2)|pancreas(1)|skin(1)	6						GTACAGCAGTGATCCAGCTGC	0.622		NA											38	174					8.16e-20	1.15e-19	1	0
CLEC4D	338339	broad.mit.edu	37	12	8667867	8667867	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr12:8667867G>T	uc001qun.2	+	2	257	c.64G>T	c.(64-66)GTT>TTT	p.V22F		NM_080387	NP_525126	Q8WXI8	CLC4D_HUMAN	C-type lectin domain family 4, member D	22	Helical; Signal-anchor for type II membrane protein; (Potential).				innate immune response	integral to membrane	sugar binding				0	Lung SC(5;0.184)					GATACCTTCGGTTATTGCTGT	0.378		NA											33	139					1.05e-18	1.46e-18	1	0
GRIN2B	2904	broad.mit.edu	37	12	13768124	13768124	+	Silent	SNP	A	A	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr12:13768124A>G	uc001rbt.2	-	7	1757	c.1578T>C	c.(1576-1578)TCT>TCC	p.S526S		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	526	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	TGAAGGGCACAGAGAAGTCGA	0.527		NA											16	92					0	0	0	0
GRIN2B	2904	broad.mit.edu	37	12	14018745	14018745	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr12:14018745A>G	uc001rbt.2	-	2	577	c.398T>C	c.(397-399)ATA>ACA	p.I133T		NM_000834	NP_000825	Q13224	NMDE2_HUMAN	N-methyl-D-aspartate receptor subunit 2B	133	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	glycine binding|N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			central_nervous_system(4)|ovary(3)|skin(3)|lung(2)	12					Felbamate(DB00949)|Haloperidol(DB00502)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	ATCTGCCATTATCATAGAGGA	0.502		NA											36	211					0	0	0	0
PDE3A	5139	broad.mit.edu	37	12	20801724	20801724	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr12:20801724G>T	uc001reh.1	+	13	2690	c.2668G>T	c.(2668-2670)GAC>TAC	p.D890Y		NM_000921	NP_000912	Q14432	PDE3A_HUMAN	phosphodiesterase 3A	890	Catalytic (By similarity).				lipid metabolic process|platelet activation|signal transduction	cytosol|integral to membrane	3',5'-cyclic-AMP phosphodiesterase activity|3',5'-cyclic-GMP phosphodiesterase activity|cGMP-inhibited cyclic-nucleotide phosphodiesterase activity|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)	4	Esophageal squamous(101;0.125)	Breast(259;0.134)			Aminophylline(DB01223)|Amrinone(DB01427)|Anagrelide(DB00261)|Cilostazol(DB01166)|Enoximone(DB04880)|Milrinone(DB00235)|Theophylline(DB00277)	AATTAACCTTGACCATGTGGA	0.408		NA											34	129					9.18e-22	1.31e-21	1	0
SLCO1B1	10599	broad.mit.edu	37	12	21327510	21327510	+	Splice_Site	SNP	G	G	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr12:21327510G>C	uc001req.3	+	4	331	c.227_splice	c.e4-1	p.G76_splice		NM_006446	NP_006437	Q9Y6L6	SO1B1_HUMAN	solute carrier organic anion transporter family,						bile acid metabolic process|sodium-independent organic anion transport	basolateral plasma membrane|integral to plasma membrane|membrane fraction	bile acid transmembrane transporter activity|sodium-independent organic anion transmembrane transporter activity|thyroid hormone transmembrane transporter activity			ovary(3)|skin(3)|pancreas(1)|central_nervous_system(1)	8					Digoxin(DB00390)|Gemfibrozil(DB01241)|Pravastatin(DB00175)	TCCCTTTCTAGGAAATTTGCT	0.363		NA											12	18					0	0	0	0
KCNH3	23416	broad.mit.edu	37	12	49936579	49936579	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr12:49936579G>C	uc001ruh.1	+	4	796	c.536G>C	c.(535-537)GGG>GCG	p.G179A	KCNH3_uc010smj.1_Missense_Mutation_p.G119A	NM_012284	NP_036416	Q9ULD8	KCNH3_HUMAN	potassium voltage-gated channel, subfamily H	179	Cytoplasmic (Potential).				regulation of transcription, DNA-dependent	integral to membrane	two-component sensor activity|voltage-gated potassium channel activity				0						CACCTGTCCGGGCACCTGCAG	0.652		NA											4	2					0	0	0	0
KRT6B	3854	broad.mit.edu	37	12	52842695	52842695	+	Silent	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr12:52842695C>T	uc001sak.2	-	6	1182	c.1134G>A	c.(1132-1134)AAG>AAA	p.K378K		NM_005555	NP_005546	P04259	K2C6B_HUMAN	keratin 6B	378	Rod.|Coil 2.				ectoderm development	keratin filament	structural constituent of cytoskeleton			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(357;0.083)		CAATCTCCTGCTTGGTGTTGC	0.552		NA											29	49					0	0	0	0
OR6C65	403282	broad.mit.edu	37	12	55794728	55794728	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr12:55794728G>A	uc010spl.1	+	1	416	c.416G>A	c.(415-417)TGT>TAT	p.C139Y		NM_001005518	NP_001005518	A6NJZ3	O6C65_HUMAN	olfactory receptor, family 6, subfamily C,	139	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						AACAAAGTCTGTAATTGGCTT	0.418		NA											56	80					0	0	0	0
NAV3	89795	broad.mit.edu	37	12	78522567	78522567	+	Silent	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr12:78522567C>T	uc001syp.2	+	18	4535	c.4362C>T	c.(4360-4362)GAC>GAT	p.D1454D	NAV3_uc001syo.2_Silent_p.D1454D|NAV3_uc010sub.1_Silent_p.D940D|NAV3_uc009zsf.2_Silent_p.D285D	NM_014903	NP_055718	Q8IVL0	NAV3_HUMAN	neuron navigator 3	1454	Ser-rich.					nuclear outer membrane	ATP binding|nucleoside-triphosphatase activity			large_intestine(6)|ovary(5)|lung(2)|breast(1)|skin(1)|kidney(1)|pancreas(1)	17						GGCTTCAGGACACTGGCAACC	0.463		NA								HNSCC(70;0.22)			24	44					0	0	0	0
LIN7A	8825	broad.mit.edu	37	12	81283142	81283142	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr12:81283142G>C	uc001szj.1	-	2	282	c.89C>G	c.(88-90)GCA>GGA	p.A30G	LIN7A_uc001szk.1_RNA	NM_004664	NP_004655	O14910	LIN7A_HUMAN	lin-7 homolog A	30	L27.				exocytosis|protein complex assembly|protein transport	basolateral plasma membrane|postsynaptic density|postsynaptic membrane|synaptosome|tight junction	L27 domain binding			ovary(1)|skin(1)	2						AATTGCTCTTGCAACATCTGA	0.343		NA											12	13					0	0	0	0
PLXNC1	10154	broad.mit.edu	37	12	94648656	94648656	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr12:94648656T>A	uc001tdc.2	+	16	3224	c.2975T>A	c.(2974-2976)ATA>AAA	p.I992K	PLXNC1_uc010sut.1_Missense_Mutation_p.I39K	NM_005761	NP_005752	O60486	PLXC1_HUMAN	plexin C1 precursor	992	Cytoplasmic (Potential).				axon guidance|cell adhesion	integral to membrane|intracellular|plasma membrane	receptor activity|receptor binding			ovary(2)|central_nervous_system(1)	3						CGGAAAGAGATACGTGACGGT	0.433		NA											4	9					0	0	0	0
PAH	5053	broad.mit.edu	37	12	103245509	103245509	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr12:103245509G>A	uc001tjq.1	-	9	1340	c.868C>T	c.(868-870)CAT>TAT	p.H290Y		NM_000277	NP_000268	P00439	PH4H_HUMAN	phenylalanine hydroxylase	290		Iron (By similarity).			catecholamine biosynthetic process|L-phenylalanine catabolic process|neurotransmitter biosynthetic process	cytosol	phenylalanine 4-monooxygenase activity			ovary(4)	4					Epinephrine(DB00668)|L-Phenylalanine(DB00120)|Levodopa(DB01235)|Norepinephrine(DB00368)|Tetrahydrobiopterin(DB00360)	AAGGGCACATGTCCCAACAGC	0.468		NA											7	26					0	0	0	0
KDM2B	84678	broad.mit.edu	37	12	121879997	121879997	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr12:121879997A>T	uc001uat.2	-	19	3351	c.3247T>A	c.(3247-3249)TGT>AGT	p.C1083S	KDM2B_uc001uaq.2_Missense_Mutation_p.C523S|KDM2B_uc010szy.1_Missense_Mutation_p.C523S|KDM2B_uc001uar.2_Missense_Mutation_p.C674S|KDM2B_uc001uas.2_Missense_Mutation_p.C1014S|KDM2B_uc001uau.2_Intron|KDM2B_uc001uao.2_Missense_Mutation_p.C331S|KDM2B_uc010szx.1_Missense_Mutation_p.C331S|KDM2B_uc001uap.2_RNA	NM_032590	NP_115979	Q8NHM5	KDM2B_HUMAN	F-box and leucine-rich repeat protein 10 isoform	1083	F-box.				embryonic camera-type eye morphogenesis|fourth ventricle development|histone H2A monoubiquitination|initiation of neural tube closure|lateral ventricle development|midbrain development|midbrain-hindbrain boundary morphogenesis|negative regulation of neural precursor cell proliferation|negative regulation of neuron apoptosis|negative regulation of transcription from RNA polymerase II promoter|spermatogenesis|third ventricle development|transcription, DNA-dependent	nucleolus	DNA binding|histone demethylase activity (H3-K36 specific)|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|rRNA binding|zinc ion binding			ovary(1)|skin(1)	2						ATGCACACACACAGGTCTTGG	0.662		NA											12	53					0	0	0	0
CKAP2	26586	broad.mit.edu	37	13	53035751	53035751	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr13:53035751C>T	uc001vgv.2	+	4	990	c.793C>T	c.(793-795)CGG>TGG	p.R265W	CKAP2_uc001vgt.2_Missense_Mutation_p.R264W|CKAP2_uc001vgu.2_Missense_Mutation_p.R264W|CKAP2_uc010tha.1_Missense_Mutation_p.R216W	NM_001098525	NP_001091995	Q8WWK9	CKAP2_HUMAN	cytoskeleton associated protein 2 isoform 2	265					apoptosis|cell cycle	centrosome|microtubule|spindle pole				ovary(1)|skin(1)	2		Breast(56;0.000207)|Lung NSC(96;0.00212)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;2.6e-08)		CAGTAATACCCGGGACACTGT	0.408		NA											14	22					0	0	0	0
PCDH20	64881	broad.mit.edu	37	13	61986650	61986650	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr13:61986650C>T	uc001vid.3	-	2	1946	c.1582G>A	c.(1582-1584)GAC>AAC	p.D528N	PCDH20_uc010thj.1_Missense_Mutation_p.D528N	NM_022843	NP_073754	Q8N6Y1	PCD20_HUMAN	protocadherin 20	501	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(4)|breast(1)|central_nervous_system(1)	6		Breast(118;0.195)|Prostate(109;0.229)		GBM - Glioblastoma multiforme(99;0.000118)		TTATCATTGTCATCTAAAAGT	0.398		NA											44	89					0	0	0	0
SLITRK5	26050	broad.mit.edu	37	13	88328295	88328295	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr13:88328295G>T	uc001vln.2	+	2	871	c.652G>T	c.(652-654)GTG>TTG	p.V218L	SLITRK5_uc010tic.1_Intron	NM_015567	NP_056382	O94991	SLIK5_HUMAN	SLIT and NTRK-like family, member 5 precursor	218	Extracellular (Potential).|LRR 6.					integral to membrane				ovary(2)|pancreas(2)|central_nervous_system(1)	5	all_neural(89;0.101)|Medulloblastoma(90;0.163)					TCTGCCCTACGTGGGGCTCTT	0.483		NA											34	51					3.33e-15	4.51e-15	1	0
DZIP1	22873	broad.mit.edu	37	13	96237044	96237044	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr13:96237044C>T	uc001vmk.2	-	22	3322	c.2470G>A	c.(2470-2472)GCT>ACT	p.A824T	DZIP1_uc001vmi.2_Missense_Mutation_p.A72T|DZIP1_uc001vmj.2_Missense_Mutation_p.A300T|DZIP1_uc001vml.2_Missense_Mutation_p.A805T|DZIP1_uc001vmm.2_5'Flank	NM_198968	NP_945319	Q86YF9	DZIP1_HUMAN	DAZ interacting protein 1 isoform 2	824					germ cell development|multicellular organismal development|spermatogenesis	cytoplasm|nucleus	nucleic acid binding|protein binding|zinc ion binding			ovary(2)	2	all_neural(89;0.0878)|Breast(111;0.148)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.141)			AGCACATGAGCAAAATGTGGT	0.438		NA											24	43					0	0	0	0
FARP1	10160	broad.mit.edu	37	13	99087858	99087858	+	Silent	SNP	G	G	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr13:99087858G>C	uc001vnj.2	+	19	2508	c.2172G>C	c.(2170-2172)GTG>GTC	p.V724V	FARP1_uc001vnh.2_Silent_p.V724V	NM_005766	NP_005757	Q9Y4F1	FARP1_HUMAN	FERM, RhoGEF, and pleckstrin domain protein 1	724	DH.				regulation of Rho protein signal transduction	cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|Rho guanyl-nucleotide exchange factor activity			breast(2)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)|Lung SC(71;0.184)		BRCA - Breast invasive adenocarcinoma(86;0.233)			CGGAGATGGTGGCACAGCTCC	0.517		NA											19	29					0	0	0	0
OR4Q3	441669	broad.mit.edu	37	14	20215674	20215674	+	Missense_Mutation	SNP	C	C	A	rs4494468		TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr14:20215674C>A	uc010tkt.1	+	1	88	c.88C>A	c.(88-90)CTA>ATA	p.L30I		NM_172194	NP_751944	Q8NH05	OR4Q3_HUMAN	olfactory receptor, family 4, subfamily Q,	30	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			breast(3)	3	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCTCTTCTTACTATTTTTGTT	0.378		NA											19	87					7.45e-12	9.67e-12	1	0
CCNB1IP1	57820	broad.mit.edu	37	14	20781866	20781866	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr14:20781866C>G	uc001vwv.2	-	6	1041	c.392G>C	c.(391-393)AGC>ACC	p.S131T	CCNB1IP1_uc001vww.2_Missense_Mutation_p.S131T|CCNB1IP1_uc001vwx.2_Missense_Mutation_p.S131T|CCNB1IP1_uc001vwy.2_Missense_Mutation_p.S131T|CCNB1IP1_uc001vwz.2_Missense_Mutation_p.S131T	NM_182851	NP_878271	Q9NPC3	CIP1_HUMAN	cyclin B1 interacting protein 1 isoform 3	131	Potential.					chromosome|nucleus	ligase activity|metal ion binding|protein binding		HMGA2/CCNB1IP1(2)	soft_tissue(2)|ovary(1)	3	all_cancers(95;0.00092)	all_lung(585;0.235)	Epithelial(56;8.86e-07)|all cancers(55;4.98e-06)	GBM - Glioblastoma multiforme(265;0.0164)		TACATCCTTGCTTTGTATTTG	0.393		NA	T	HMGA2	leiomyoma								5	103					0	0	0	0
SALL2	6297	broad.mit.edu	37	14	21991721	21991721	+	Missense_Mutation	SNP	A	A	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr14:21991721A>C	uc001wbe.2	-	2	2423	c.2141T>G	c.(2140-2142)CTG>CGG	p.L714R	SALL2_uc010tly.1_Missense_Mutation_p.L712R|SALL2_uc010tlz.1_Missense_Mutation_p.L577R|SALL2_uc001wbf.3_Intron|SALL2_uc010tma.1_Missense_Mutation_p.L579R|SALL2_uc001wbg.1_Intron	NM_005407	NP_005398	Q9Y467	SALL2_HUMAN	sal-like 2	714							DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|large_intestine(1)	3	all_cancers(95;0.000662)			GBM - Glioblastoma multiforme(265;0.0151)		CTGGCCCCCCAGGTGCATCCG	0.607		NA											5	36					0	0	0	0
IPO4	79711	broad.mit.edu	37	14	24652822	24652822	+	Silent	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr14:24652822G>A	uc001wmv.1	-	20	2168	c.2037C>T	c.(2035-2037)GCC>GCT	p.A679A	IPO4_uc001wmt.1_Silent_p.A157A|IPO4_uc001wmu.2_Silent_p.A341A|IPO4_uc001wmx.1_Silent_p.A543A|IPO4_uc001wmy.1_Silent_p.A543A|IPO4_uc010tnz.1_RNA|IPO4_uc001wmw.1_RNA|IPO4_uc001wmz.1_Silent_p.A679A	NM_024658	NP_078934	Q8TEX9	IPO4_HUMAN	importin 4	679					intracellular protein transport	cytoplasm|nucleus	protein binding|protein transporter activity			kidney(1)	1				GBM - Glioblastoma multiforme(265;0.0087)		TCTCCCCCACGGCAGCACAGG	0.577		NA											8	44					0	0	0	0
RALGAPA1	253959	broad.mit.edu	37	14	36128345	36128345	+	Nonsense_Mutation	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr14:36128345G>A	uc001wti.2	-	27	4259	c.3868C>T	c.(3868-3870)CGA>TGA	p.R1290*	RALGAPA1_uc010amp.2_RNA|RALGAPA1_uc001wtj.2_Nonsense_Mutation_p.R1290*|RALGAPA1_uc010tpv.1_Nonsense_Mutation_p.R1303*|RALGAPA1_uc010tpw.1_Nonsense_Mutation_p.R1337*	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	1290					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						CCGACCTACCGTGCAGGACCA	0.373		NA											9	27					0	0	0	0
SSTR1	6751	broad.mit.edu	37	14	38678848	38678848	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr14:38678848G>T	uc001wul.1	+	3	871	c.254G>T	c.(253-255)CGC>CTC	p.R85L	SSTR1_uc010amu.1_Intron	NM_001049	NP_001040	P30872	SSR1_HUMAN	somatostatin receptor 1	85	Cytoplasmic (Potential).				digestion|G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation|response to nutrient	integral to plasma membrane	somatostatin receptor activity			central_nervous_system(3)|ovary(1)|lung(1)	5	Hepatocellular(127;0.213)|Esophageal squamous(585;0.22)		Lung(238;3.93e-06)|LUAD - Lung adenocarcinoma(48;2.62e-05)|Epithelial(34;0.187)	GBM - Glioblastoma multiforme(112;0.00444)	Octreotide(DB00104)	GTGATCCTGCGCTATGCCAAG	0.562		NA											22	87					1.97e-08	2.41e-08	1	0
RPL10L	140801	broad.mit.edu	37	14	47120455	47120455	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr14:47120455C>A	uc001wwg.2	-	1	574	c.485G>T	c.(484-486)CGC>CTC	p.R162L		NM_080746	NP_542784	Q96L21	RL10L_HUMAN	ribosomal protein L10-like protein	162					spermatogenesis|translation	cytosolic large ribosomal subunit|nucleus	structural constituent of ribosome			ovary(1)	1						AATCTTCTGGCGTCCAGGGAA	0.498		NA											35	103					5.83e-16	7.96e-16	1	0
ARF6	382	broad.mit.edu	37	14	50360768	50360768	+	Missense_Mutation	SNP	G	G	C	rs61755568		TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr14:50360768G>C	uc001wxg.3	+	2	935	c.314G>C	c.(313-315)CGC>CCC	p.R105P		NM_001663	NP_001654	P62330	ARF6_HUMAN	ADP-ribosylation factor 6	105					cell adhesion|cellular component movement|cortical actin cytoskeleton organization|negative regulation of receptor-mediated endocytosis|positive regulation of actin filament polymerization|positive regulation of establishment of protein localization in plasma membrane|protein localization at cell surface|protein transport|regulation of dendritic spine development|regulation of filopodium assembly|regulation of Rac protein signal transduction|ruffle organization|small GTPase mediated signal transduction|vesicle-mediated transport	cell cortex|endosome membrane|filopodium membrane|Golgi apparatus|membrane fraction|ruffle	GTP binding|GTPase activity|thioesterase binding				0	all_epithelial(31;0.000822)|Breast(41;0.0117)					GAGCTGCACCGCATTATCAAT	0.587		NA											15	45					0	0	0	0
NRXN3	9369	broad.mit.edu	37	14	80164140	80164140	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr14:80164140C>A	uc001xun.2	+	15	3156	c.2665C>A	c.(2665-2667)CTG>ATG	p.L889M	NRXN3_uc001xum.1_RNA|NRXN3_uc001xup.2_RNA|NRXN3_uc001xuq.2_Missense_Mutation_p.L257M|NRXN3_uc010asw.2_Missense_Mutation_p.L287M|NRXN3_uc001xur.3_Missense_Mutation_p.L257M	NM_004796	NP_004787	Q9Y4C0	NRX3A_HUMAN	neurexin 3 isoform 1 precursor	1262	Extracellular (Potential).				axon guidance|cell adhesion	integral to plasma membrane	metal ion binding|receptor activity			ovary(3)|upper_aerodigestive_tract(2)|pancreas(2)|central_nervous_system(1)|breast(1)|skin(1)	10		Renal(4;0.00876)		BRCA - Breast invasive adenocarcinoma(234;0.00544)|Kidney(3;0.029)|KIRC - Kidney renal clear cell carcinoma(182;0.223)		AAGTGTTCGGCTGGTTGGAGA	0.458		NA											17	44					5.39e-06	6.26e-06	1	0
DICER1	23405	broad.mit.edu	37	14	95574699	95574699	+	Silent	SNP	T	T	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr14:95574699T>G	uc001ydw.2	-	16	2580	c.2398A>C	c.(2398-2400)AGA>CGA	p.R800R	DICER1_uc010avh.1_5'Flank|DICER1_uc001ydv.2_Silent_p.R790R|DICER1_uc001ydx.2_Silent_p.R800R	NM_030621	NP_085124	Q9UPY3	DICER_HUMAN	dicer1	800					negative regulation of Schwann cell proliferation|negative regulation of transcription from RNA polymerase II promoter|nerve development|neuron projection morphogenesis|peripheral nervous system myelin formation|positive regulation of myelination|positive regulation of Schwann cell differentiation|pre-miRNA processing|production of siRNA involved in RNA interference|targeting of mRNA for destruction involved in RNA interference	cytosol|RNA-induced silencing complex	ATP binding|ATP-dependent helicase activity|double-stranded RNA binding|metal ion binding|protein binding|ribonuclease III activity			skin(2)|ovary(1)|pancreas(1)|lung(1)	5		all_cancers(154;0.0621)|all_epithelial(191;0.223)		Epithelial(152;0.211)|COAD - Colon adenocarcinoma(157;0.215)		CCAAAGCATCTTGTGGTATCT	0.398		NA	Mis F|N			pleuropulmonary blastoma			DICER_1_syndrome_|Familial_Multinodular_Goiter_				34	135					0	0	0	0
DLK1	8788	broad.mit.edu	37	14	101194741	101194741	+	Missense_Mutation	SNP	T	T	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr14:101194741T>G	uc001yhs.3	+	2	229	c.76T>G	c.(76-78)TGC>GGC	p.C26G	DLK1_uc001yhu.3_Missense_Mutation_p.C26G	NM_003836	NP_003827	P80370	DLK1_HUMAN	delta-like 1 homolog precursor	26	Extracellular (Potential).|EGF-like 1.				multicellular organismal development	extracellular space|integral to membrane|soluble fraction				ovary(2)|breast(1)|skin(1)	4		Melanoma(154;0.155)				AGGGGCTGAATGCTTCCCGGC	0.572		NA											30	73					0	0	0	0
ATP10A	57194	broad.mit.edu	37	15	25940061	25940061	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr15:25940061C>A	uc010ayu.2	-	14	3099	c.2993G>T	c.(2992-2994)TGC>TTC	p.C998F		NM_024490	NP_077816	O60312	AT10A_HUMAN	ATPase, class V, type 10A	998	Cytoplasmic (Potential).				ATP biosynthetic process|regulation of cell shape	integral to membrane|plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			pancreas(2)|ovary(1)|breast(1)|liver(1)	5		all_cancers(20;5.16e-25)|all_lung(180;1.51e-14)|Acute lymphoblastic leukemia(1;2.53e-05)|all_hematologic(1;0.000267)|Breast(32;0.00125)		all cancers(64;9.48e-07)|Epithelial(43;1.69e-06)|BRCA - Breast invasive adenocarcinoma(123;0.0252)|Lung(196;0.244)		GACGGAGCGGCACTGCTTGGC	0.607		NA											18	38					1.68e-08	2.06e-08	1	0
TJP1	7082	broad.mit.edu	37	15	30012801	30012801	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr15:30012801C>T	uc001zcr.2	-	19	2999	c.2524G>A	c.(2524-2526)GAC>AAC	p.D842N	TJP1_uc010azl.2_Missense_Mutation_p.D830N|TJP1_uc001zcq.2_Missense_Mutation_p.D846N|TJP1_uc001zcs.2_Missense_Mutation_p.D842N	NM_003257	NP_003248	Q07157	ZO1_HUMAN	tight junction protein 1 isoform a	842					cell-cell junction assembly|cellular component disassembly involved in apoptosis	basolateral plasma membrane|cell-cell adherens junction|Golgi apparatus|tight junction				ovary(4)|central_nervous_system(1)|pancreas(1)	6		all_lung(180;7.48e-11)|Breast(32;0.000153)		all cancers(64;3.29e-10)|Epithelial(43;5.34e-09)|BRCA - Breast invasive adenocarcinoma(123;0.0034)|GBM - Glioblastoma multiforme(186;0.0139)|Lung(196;0.186)		TCTTCATAGTCAGAAGTGTGT	0.463		NA											30	44					0	0	0	0
OTUD7A	161725	broad.mit.edu	37	15	31819495	31819495	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr15:31819495G>C	uc001zfq.2	-	5	762	c.669C>G	c.(667-669)CAC>CAG	p.H223Q	OTUD7A_uc001zfr.2_Missense_Mutation_p.H223Q	NM_130901	NP_570971	Q8TE49	OTU7A_HUMAN	OTU domain containing 7A	223	OTU.|Catalytic (By similarity).|TRAF-binding (By similarity).					cytoplasm|nucleus	cysteine-type peptidase activity|DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		all_lung(180;1.6e-09)		all cancers(64;2.44e-19)|Epithelial(43;6.82e-14)|GBM - Glioblastoma multiforme(186;1.49e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00189)|Lung(196;0.208)		GGTCCCGGTCGTGAAACCCCC	0.577		NA											16	171					0	0	0	0
RYR3	6263	broad.mit.edu	37	15	33855069	33855069	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr15:33855069A>T	uc001zhi.2	+	11	1074	c.1004A>T	c.(1003-1005)AAG>ATG	p.K335M	RYR3_uc010bar.2_Missense_Mutation_p.K335M	NM_001036	NP_001027	Q15413	RYR3_HUMAN	ryanodine receptor 3	335	Cytoplasmic (By similarity).				cellular calcium ion homeostasis	integral to membrane	calcium ion binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(5)|central_nervous_system(4)|lung(1)	10		all_lung(180;7.18e-09)		all cancers(64;8.95e-12)|GBM - Glioblastoma multiforme(186;0.00109)|BRCA - Breast invasive adenocarcinoma(123;0.0363)		TCCAGTCACAAGCGAGACATA	0.403		NA											13	27					0	0	0	0
LTK	4058	broad.mit.edu	37	15	41801279	41801279	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr15:41801279C>A	uc001zoa.3	-	8	1224	c.1046G>T	c.(1045-1047)GGA>GTA	p.G349V	LTK_uc001zob.3_Missense_Mutation_p.G288V|LTK_uc010ucx.1_Missense_Mutation_p.G288V|LTK_uc010bcg.2_Missense_Mutation_p.G31V	NM_002344	NP_002335	P29376	LTK_HUMAN	leukocyte receptor tyrosine kinase isoform 1	349	Extracellular (Potential).				apoptosis|cell proliferation|phosphatidylinositol 3-kinase cascade|transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane|soluble fraction	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(6)|central_nervous_system(1)	7		all_cancers(109;1.89e-19)|all_epithelial(112;2.28e-16)|Lung NSC(122;5.34e-11)|all_lung(180;1.33e-09)|Melanoma(134;0.0179)|Ovarian(310;0.143)|Colorectal(260;0.172)		OV - Ovarian serous cystadenocarcinoma(18;2.1e-17)|GBM - Glioblastoma multiforme(113;1.34e-06)|Colorectal(105;0.0148)|BRCA - Breast invasive adenocarcinoma(123;0.113)		GAAGGATACTCCATCTTCCCC	0.577		NA								TSP Lung(18;0.14)			9	79					1.77e-08	2.17e-08	1	0
SPATA5L1	79029	broad.mit.edu	37	15	45695581	45695581	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr15:45695581G>C	uc001zve.2	+	1	1063	c.954G>C	c.(952-954)GAG>GAC	p.E318D	uc001zvd.2_5'Flank|SPATA5L1_uc001zvf.2_RNA	NM_024063	NP_076968	Q9BVQ7	SPA5L_HUMAN	spermatogenesis associated 5-like 1	318						cytoplasm	ATP binding|nucleoside-triphosphatase activity			ovary(3)|skin(1)	4		Lung NSC(122;8.3e-05)|all_lung(180;0.000547)|Melanoma(134;0.0417)		all cancers(107;7.31e-17)|GBM - Glioblastoma multiforme(94;6.28e-07)		GAGCACCCGAGAGCCGCGTAG	0.697		NA											11	15					0	0	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84582010	84582010	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr15:84582010G>A	uc002bjz.3	+	16	2091	c.1867G>A	c.(1867-1869)GAA>AAA	p.E623K	ADAMTSL3_uc010bmt.1_Missense_Mutation_p.E623K|ADAMTSL3_uc010bmu.1_Missense_Mutation_p.E623K	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	623	TSP type-1 4.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			CTGCCTCCTGGAAGCATGTGA	0.612		NA											12	24					0	0	0	0
ALPK3	57538	broad.mit.edu	37	15	85360196	85360196	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr15:85360196G>T	uc002ble.2	+	1	286	c.119G>T	c.(118-120)CGG>CTG	p.R40L		NM_020778	NP_065829	Q96L96	ALPK3_HUMAN	alpha-kinase 3	40					heart development	nucleus	ATP binding|protein serine/threonine kinase activity			stomach(3)|ovary(3)|lung(2)|skin(2)|central_nervous_system(1)|breast(1)	12			BRCA - Breast invasive adenocarcinoma(143;0.0587)			GGTCTCCCGCGGTCTAGCCCA	0.682		NA											4	30					0.00909568	0.00951548	1	0
SV2B	9899	broad.mit.edu	37	15	91811780	91811780	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr15:91811780A>G	uc002bqv.2	+	8	1709	c.1318A>G	c.(1318-1320)ATC>GTC	p.I440V	SV2B_uc002bqt.2_Missense_Mutation_p.I440V|SV2B_uc010uqv.1_Missense_Mutation_p.I289V|SV2B_uc002bqu.3_RNA	NM_014848	NP_055663	Q7L1I2	SV2B_HUMAN	synaptic vesicle protein 2B homolog	440	Extracellular (Potential).				neurotransmitter transport	acrosomal vesicle|cell junction|integral to membrane|synaptic vesicle membrane	transmembrane transporter activity			ovary(3)|central_nervous_system(2)|skin(2)|upper_aerodigestive_tract(1)	8	Lung NSC(78;0.0987)|all_lung(78;0.172)		BRCA - Breast invasive adenocarcinoma(143;0.0895)			CGGCGCCACAATCAACTTCAC	0.428		NA											19	105					0	0	0	0
IFT140	9742	broad.mit.edu	37	16	1570757	1570757	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr16:1570757T>C	uc002cmb.2	-	27	3868	c.3506A>G	c.(3505-3507)GAG>GGG	p.E1169G	IFT140_uc002clz.2_Missense_Mutation_p.E782G	NM_014714	NP_055529	Q96RY7	IF140_HUMAN	intraflagellar transport 140	1169										ovary(3)|pancreas(1)|skin(1)	5		Hepatocellular(780;0.219)				TTCCGCCATCTCCTCGGTGAT	0.632		NA											11	37					0	0	0	0
PKMYT1	9088	broad.mit.edu	37	16	3024069	3024069	+	Silent	SNP	A	A	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr16:3024069A>T	uc002csn.2	-	7	1685	c.1242T>A	c.(1240-1242)CCT>CCA	p.P414P	PKMYT1_uc010uwn.1_RNA|PKMYT1_uc002csm.2_Silent_p.P414P|PKMYT1_uc002cso.2_Silent_p.P345P|PKMYT1_uc002csp.2_Silent_p.P405P|PKMYT1_uc002csq.2_Silent_p.P405P|PKMYT1_uc010bsy.1_Silent_p.P405P	NM_004203	NP_004194	Q99640	PMYT1_HUMAN	protein kinase Myt1 isoform 1	414	Interaction with PIN1.				G1/S transition of mitotic cell cycle|G2/M transition of mitotic cell cycle|mitosis|regulation of cyclin-dependent protein kinase activity|regulation of mitosis	endoplasmic reticulum membrane|Golgi membrane|membrane fraction|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(1)	1						GTGGTGAGCCAGGCGGGGTGG	0.677		NA											6	19					0	0	0	0
GRIN2A	2903	broad.mit.edu	37	16	9857816	9857816	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr16:9857816G>T	uc002czo.3	-	13	4133	c.3585C>A	c.(3583-3585)GAC>GAA	p.D1195E	GRIN2A_uc010uym.1_Missense_Mutation_p.D1195E|GRIN2A_uc010uyn.1_Missense_Mutation_p.D1038E|GRIN2A_uc002czr.3_Missense_Mutation_p.D1195E	NM_001134407	NP_001127879	Q12879	NMDE1_HUMAN	N-methyl-D-aspartate receptor subunit 2A isoform	1195	Cytoplasmic (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|outer membrane-bounded periplasmic space|postsynaptic membrane	N-methyl-D-aspartate selective glutamate receptor activity|zinc ion binding			skin(32)|NS(5)|ovary(4)|large_intestine(1)|lung(1)|breast(1)|kidney(1)	45					Felbamate(DB00949)|Glycine(DB00145)|L-Glutamic Acid(DB00142)|Loperamide(DB00836)|Memantine(DB01043)	GGGAACCCTTGTCTTTCAAGG	0.532		NA											62	223					3.89e-28	5.6e-28	1	0
XYLT1	64131	broad.mit.edu	37	16	17211771	17211771	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr16:17211771C>A	uc002dfa.2	-	11	2374	c.2289G>T	c.(2287-2289)ATG>ATT	p.M763I		NM_022166	NP_071449	Q86Y38	XYLT1_HUMAN	xylosyltransferase I	763	Lumenal (Potential).				glycosaminoglycan biosynthetic process	endoplasmic reticulum membrane|extracellular region|Golgi membrane|integral to membrane	acetylglucosaminyltransferase activity|protein xylosyltransferase activity			ovary(4)	4						CCGGCTCATCCATGGGCCCCA	0.572		NA											14	42					1.36e-06	1.61e-06	1	0
SCNN1B	6338	broad.mit.edu	37	16	23391744	23391744	+	Silent	SNP	C	C	T	rs61759916	byFrequency	TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr16:23391744C>T	uc002dln.2	+	13	1721	c.1545C>T	c.(1543-1545)ATC>ATT	p.I515I		NM_000336	NP_000327	P51168	SCNNB_HUMAN	sodium channel, nonvoltage-gated 1, beta	515	Helical; (By similarity).				excretion|sensory perception of taste	apical plasma membrane	ligand-gated sodium channel activity|WW domain binding			ovary(3)|breast(2)|large_intestine(1)|pancreas(1)	7				GBM - Glioblastoma multiforme(48;0.0465)	Amiloride(DB00594)|Triamterene(DB00384)	CCCCACAGATCGTCTGGCTGC	0.582		NA											28	74					0	0	0	0
PALB2	79728	broad.mit.edu	37	16	23640992	23640992	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr16:23640992C>A	uc002dlx.1	-	5	2683	c.2483G>T	c.(2482-2484)TGC>TTC	p.C828F		NM_024675	NP_078951	Q86YC2	PALB2_HUMAN	partner and localizer of BRCA2	828					double-strand break repair via homologous recombination	nucleoplasm	DNA binding|protein binding			lung(3)|breast(3)|ovary(2)|skin(1)|kidney(1)|pancreas(1)	11				GBM - Glioblastoma multiforme(48;0.0167)		CAGCTCCTGGCATGTGTTTCT	0.438		NA	F|N|Mis			Wilms tumor|medulloblastoma|AML ,breast		Direct_reversal_of_damage|Involved_in_tolerance_or_repair_of_DNA_crosslinks	Fanconi_Anemia_type_N|Fanconi_Anemia|PALB2-associated_Familial_Breast_and_Pancreatic_Cancer|Pancreatic_Cancer_Familial_Clustering_of				17	51					6.5e-13	8.57e-13	1	0
RBBP6	5930	broad.mit.edu	37	16	24578538	24578538	+	Missense_Mutation	SNP	T	T	G	rs16973840		TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr16:24578538T>G	uc002dmh.2	+	15	2704	c.1664T>G	c.(1663-1665)GTC>GGC	p.V555G	RBBP6_uc010vcb.1_Missense_Mutation_p.V422G|RBBP6_uc002dmi.2_Missense_Mutation_p.V555G|RBBP6_uc010bxr.2_Intron|RBBP6_uc002dmk.2_Missense_Mutation_p.V422G	NM_006910	NP_008841	Q7Z6E9	RBBP6_HUMAN	retinoblastoma-binding protein 6 isoform 1	555					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	chromosome|nucleolus|ubiquitin ligase complex	nucleic acid binding|protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(3)|pancreas(1)	4				GBM - Glioblastoma multiforme(48;0.0518)		GCAACTCCAGTCTTTGTAcct	0.239		NA											16	47					0	0	0	0
ATP2A1	487	broad.mit.edu	37	16	28895897	28895897	+	Silent	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr16:28895897G>T	uc002dro.1	+	6	649	c.465G>T	c.(463-465)GTG>GTT	p.V155V	uc010vct.1_Intron|ATP2A1_uc002drn.1_Silent_p.V155V|ATP2A1_uc002drp.1_Silent_p.V30V	NM_173201	NP_775293	O14983	AT2A1_HUMAN	ATPase, Ca++ transporting, fast twitch 1 isoform	155	Cytoplasmic (By similarity).				apoptosis in response to endoplasmic reticulum stress|apoptotic mitochondrial changes|ATP biosynthetic process|calcium ion import|elevation of endoplasmic reticulum calcium ion concentration|elevation of mitochondrial calcium ion concentration|maintenance of mitochondrion location|negative regulation of striated muscle contraction|platelet activation|positive regulation of fast-twitch skeletal muscle fiber contraction|reduction of endoplasmic reticulum calcium ion concentration|relaxation of skeletal muscle|response to endoplasmic reticulum stress	endoplasmic reticulum membrane|ER-Golgi intermediate compartment|H zone|I band|microsome|perinuclear region of cytoplasm|platelet dense tubular network membrane|sarcoplasmic reticulum|sarcoplasmic reticulum membrane	ATP binding|ATP binding|calcium ion binding|calcium ion binding|calcium-transporting ATPase activity|protein homodimerization activity			ovary(2)|central_nervous_system(1)|pancreas(1)	4						TCTCCACAGTGGGGGACAAAG	0.532		NA											14	36					8.6e-14	1.15e-13	1	0
SETD1A	9739	broad.mit.edu	37	16	30977521	30977521	+	Silent	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr16:30977521C>T	uc002ead.1	+	8	3005	c.2319C>T	c.(2317-2319)CCC>CCT	p.P773P		NM_014712	NP_055527	O15047	SET1A_HUMAN	SET domain containing 1A	773					regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nuclear speck|Set1C/COMPASS complex	histone-lysine N-methyltransferase activity|nucleotide binding|protein binding|RNA binding			ovary(2)|skin(1)	3						GGCTGCCACCCAGGGAAGAAG	0.667		NA											8	40					0	0	0	0
STX4	6810	broad.mit.edu	37	16	31045834	31045834	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr16:31045834G>T	uc002eal.2	+	4	508	c.284G>T	c.(283-285)AGG>ATG	p.R95M	STX4_uc002eak.2_Missense_Mutation_p.R93M|STX4_uc002eam.2_Missense_Mutation_p.R17M	NM_004604	NP_004595	Q12846	STX4_HUMAN	syntaxin 4	95	Cytoplasmic (Potential).|Potential.				intracellular protein transport|platelet activation|post-Golgi vesicle-mediated transport	basolateral plasma membrane|cell surface|cytosol|integral to membrane|plasma membrane enriched fraction|specific granule|vacuole	SNAP receptor activity				0						CAGCTGGGGAGGGAGATCCGC	0.383		NA											8	20					0.00307968	0.003284	1	0
ABCC12	94160	broad.mit.edu	37	16	48119591	48119591	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr16:48119591C>A	uc002efc.1	-	27	4087	c.3741G>T	c.(3739-3741)CAG>CAT	p.Q1247H	ABCC12_uc002eey.1_RNA|ABCC12_uc002eez.1_RNA|ABCC12_uc002efa.1_RNA|ABCC12_uc002efb.1_RNA|ABCC12_uc002efd.1_RNA	NM_033226	NP_150229	Q96J65	MRP9_HUMAN	ATP-binding cassette protein C12	1247	ABC transporter 2.					integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			ovary(2)|skin(1)	3		all_cancers(37;0.0474)|all_lung(18;0.047)				TGACTTCTGCCTGTAATTTTT	0.403		NA											31	53					1.08e-15	1.47e-15	1	0
HSF4	3299	broad.mit.edu	37	16	67201122	67201122	+	Silent	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr16:67201122G>A	uc002erl.1	+	9	1691	c.726G>A	c.(724-726)CAG>CAA	p.Q242Q	HSF4_uc002erm.1_Silent_p.Q242Q|HSF4_uc002ern.1_RNA|HSF4_uc010cec.1_RNA	NM_001040667	NP_001035757	Q9ULV5	HSF4_HUMAN	heat shock transcription factor 4 isoform b	242					response to stress	nucleus	sequence-specific DNA binding transcription factor activity|transcription corepressor activity				0		Ovarian(137;0.0563)		OV - Ovarian serous cystadenocarcinoma(108;0.0143)|Epithelial(162;0.0335)|all cancers(182;0.184)		ACTTCATCCAGTCGGTAGGTT	0.567		NA											18	39					0	0	0	0
MPHOSPH6	10200	broad.mit.edu	37	16	82182435	82182435	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr16:82182435C>G	uc002fgw.2	-	5	433	c.384G>C	c.(382-384)AAG>AAC	p.K128N		NM_005792	NP_005783	Q99547	MPH6_HUMAN	M-phase phosphoprotein 6	128	Nuclear localization signal (Potential).				M phase of mitotic cell cycle|maturation of 5.8S rRNA	cytoplasm|nucleolus	protein binding|RNA binding				0						TTCTGGCAAACTTTTTCCCAA	0.398		NA											40	85					0	0	0	0
MYBBP1A	10514	broad.mit.edu	37	17	4443014	4443014	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr17:4443014G>C	uc002fyb.3	-	26	3745	c.3683C>G	c.(3682-3684)CCA>CGA	p.P1228R	MYBBP1A_uc002fxz.3_Missense_Mutation_p.P1228R|SPNS2_uc002fxx.2_3'UTR|SPNS2_uc002fxy.2_3'UTR|MYBBP1A_uc002fya.3_Missense_Mutation_p.P173R|MYBBP1A_uc010vsa.1_Missense_Mutation_p.P270R	NM_014520	NP_055335	Q9BQG0	MBB1A_HUMAN	MYB binding protein 1a isoform 2	1228	Required for nuclear and nucleolar localization (By similarity).				nucleocytoplasmic transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|NLS-dependent protein nuclear import complex|nucleolus	DNA binding|DNA-directed DNA polymerase activity|transcription factor binding			ovary(1)|skin(1)	2						CTTGGTGGTTGGCGTCCCGTT	0.652		NA											33	117					0	0	0	0
BCL6B	255877	broad.mit.edu	37	17	6927486	6927486	+	Silent	SNP	C	C	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr17:6927486C>G	uc002geg.2	+	3	321	c.264C>G	c.(262-264)GGC>GGG	p.G88G	BCL6B_uc010clt.1_Silent_p.G88G	NM_181844	NP_862827	Q8N143	BCL6B_HUMAN	B-cell CLL/lymphoma 6, member B (zinc finger	88	BTB.					nucleus	zinc ion binding			skin(1)	1						AAGCGAGAGGCTTCGCCCCTC	0.612		NA											66	143					0	0	0	0
POLR2A	5430	broad.mit.edu	37	17	7399318	7399318	+	Missense_Mutation	SNP	G	G	C	rs150809300		TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr17:7399318G>C	uc002ghf.3	+	2	386	c.152G>C	c.(151-153)CGC>CCC	p.R51P	POLR2A_uc002ghe.2_Missense_Mutation_p.R51P	NM_000937	NP_000928	P24928	RPB1_HUMAN	DNA-directed RNA polymerase II A	51					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|regulation of transcription, DNA-dependent|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|RNA-directed RNA polymerase activity|ubiquitin protein ligase binding			pancreas(1)	1		Prostate(122;0.173)				GAGGGAGGCCGCCCCAAGCTT	0.592		NA											26	73					0	0	0	0
TP53	7157	broad.mit.edu	37	17	7577081	7577081	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr17:7577081T>A	uc002gim.2	-	8	1051	c.857A>T	c.(856-858)GAA>GTA	p.E286V	TP53_uc002gig.1_Intron|TP53_uc002gih.2_Missense_Mutation_p.E286V|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Missense_Mutation_p.E154V|TP53_uc010cng.1_Missense_Mutation_p.E154V|TP53_uc002gii.1_Missense_Mutation_p.E154V|TP53_uc010cnh.1_Missense_Mutation_p.E286V|TP53_uc010cni.1_Missense_Mutation_p.E286V|TP53_uc002gij.2_Missense_Mutation_p.E286V	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	286	|Interaction with E4F1.|Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		E -> V (in sporadic cancers; somatic mutation).|E -> K (in sporadic cancers; somatic mutation).|E -> D (in sporadic cancers; somatic mutation).|E -> L (in a sporadic cancer; somatic mutation; requires 2 nucleotide substitutions).|E -> G (in sporadic cancers; somatic mutation).|E -> Q (in sporadic cancers; somatic mutation).|E -> A (in LFS; germline mutation and in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.E286K(50)|p.E286*(14)|p.E286G(14)|p.0?(7)|p.E286V(6)|p.E286Q(5)|p.?(2)|p.E286D(2)|p.E286E(2)|p.R283fs*16(2)|p.E286fs*59(2)|p.E286fs*17(2)|p.E285_N288delEEEN(1)|p.R282_E287delRRTEEE(1)|p.T284_G293del10(1)|p.E285fs*13(1)|p.L265_K305del41(1)|p.T284fs*57(1)|p.R283fs*56(1)|p.E286A(1)|p.V272_K292del21(1)|p.E285_L289delEEENL(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		GAGATTCTCTTCCTCTGTGCG	0.562		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			23	63					0	0	0	0
MYH2	4620	broad.mit.edu	37	17	10432120	10432120	+	Nonsense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr17:10432120C>A	uc010coi.2	-	27	3759	c.3631G>T	c.(3631-3633)GAG>TAG	p.E1211*	uc002gml.1_Intron|MYH2_uc002gmp.3_Nonsense_Mutation_p.E1211*|MYH2_uc010coj.2_Intron	NM_001100112	NP_001093582	Q9UKX2	MYH2_HUMAN	myosin heavy chain IIa	1211	Potential.				muscle filament sliding	muscle myosin complex|myosin filament|sarcomere	actin binding|ATP binding|calmodulin binding|microfilament motor activity|structural constituent of muscle			ovary(5)|pancreas(4)|skin(3)|lung(1)|kidney(1)	14						TCAATCTGCTCCCCAAGCTCG	0.537		NA											24	81					3.01e-09	3.77e-09	1	0
SLC47A1	55244	broad.mit.edu	37	17	19480696	19480697	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr17:19480696_19480697CC>AA	uc002gvy.1	+	17	1629_1630	c.1543_1544CC>AA	c.(1543-1545)CCT>AAT	p.P515N	SLC47A1_uc002gvx.2_Missense_Mutation_p.P515N|SLC47A1_uc010vyz.1_3'UTR|SLC47A1_uc010cqp.1_Missense_Mutation_p.P213N|SLC47A1_uc010cqq.1_Missense_Mutation_p.P261N|SLC47A1_uc010vza.1_Missense_Mutation_p.P227N|SLC47A1_uc010vzb.1_Missense_Mutation_p.P190N|SLC47A1_uc010vzc.1_Missense_Mutation_p.P187N	NM_018242	NP_060712	Q96FL8	S47A1_HUMAN	solute carrier family 47, member 1	515	Cytoplasmic (Potential).					integral to membrane|plasma membrane	drug:hydrogen antiporter activity				0	all_cancers(12;2.49e-05)|all_epithelial(12;0.00263)|Hepatocellular(7;0.00345)					GACAGGCGAGCCTCAGTCAGAT	0.495		NA											41	110					0	0	0	0
KCNJ12	3768	broad.mit.edu	37	17	21319644	21319644	+	Silent	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr17:21319644G>T	uc002gyv.1	+	3	1695	c.990G>T	c.(988-990)GTG>GTT	p.V330V		NM_021012	NP_066292	Q14500	IRK12_HUMAN	potassium inwardly-rectifying channel, subfamily	330	Cytoplasmic (By similarity).				blood circulation|muscle contraction|regulation of heart contraction|synaptic transmission	integral to membrane	inward rectifier potassium channel activity|ion channel inhibitor activity|potassium channel regulator activity			ovary(3)|skin(1)	4				Colorectal(15;0.0183)|COAD - Colon adenocarcinoma(3;0.0732)	Dofetilide(DB00204)	TTGAGCCCGTGCTCTTCGAGG	0.587		NA								Prostate(3;0.18)			30	211					9.78e-22	1.39e-21	1	0
FOXK2	3607	broad.mit.edu	37	17	80477969	80477969	+	Missense_Mutation	SNP	A	A	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr17:80477969A>C	uc002kfn.2	+	1	376	c.205A>C	c.(205-207)ATG>CTG	p.M69L	FOXK2_uc002kfm.1_Missense_Mutation_p.M69L|FOXK2_uc010diu.2_Missense_Mutation_p.M69L	NM_004514	NP_004505	Q01167	FOXK2_HUMAN	forkhead box K2	69	FHA.|Gly-rich.			AAAAALSGAGTPPAGGGAGGGGAGGGGSPPGGWAVARLEGR EFEYLMKKRSVTIGRNSSQGSVDVSMGHSSFISRRHLEIFT PPGGGGHGGAAPELPPAQPRPDAGGDFYLRCLGKNG -> Q (in Ref. 1; CAA43200).	embryo development|pattern specification process|regulation of sequence-specific DNA binding transcription factor activity|regulation of transcription from RNA polymerase II promoter|tissue development	transcription factor complex	DNA bending activity|double-stranded DNA binding|magnesium ion binding|promoter binding|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding				0	Breast(20;0.00106)|all_neural(118;0.0952)		OV - Ovarian serous cystadenocarcinoma(97;0.0371)|BRCA - Breast invasive adenocarcinoma(99;0.0415)			GGACGTGAGCATGGGCCACTC	0.478		NA											4	40					0	0	0	0
TMEM200C	645369	broad.mit.edu	37	18	5891793	5891793	+	Silent	SNP	C	C	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr18:5891793C>G	uc002kmx.1	-	1	311	c.270G>C	c.(268-270)CCG>CCC	p.P90P		NM_001080209	NP_001073678	A6NKL6	T200C_HUMAN	transmembrane protein 200C	90						integral to membrane					0						TGCCCGCAGGCGGCAGCTGCT	0.672		NA											26	26					0	0	0	0
PTPRM	5797	broad.mit.edu	37	18	7955363	7955363	+	Silent	SNP	T	T	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr18:7955363T>A	uc002knn.3	+	7	1586	c.1083T>A	c.(1081-1083)GGT>GGA	p.G361G	PTPRM_uc010dkv.2_Silent_p.G361G|PTPRM_uc010wzl.1_Silent_p.G148G	NM_002845	NP_002836	P28827	PTPRM_HUMAN	protein tyrosine phosphatase, receptor type, M	361	Fibronectin type-III 1.|Extracellular (Potential).				homophilic cell adhesion|negative regulation of angiogenesis|negative regulation of endothelial cell migration|negative regulation of endothelial cell proliferation|response to drug|retina layer formation|retinal ganglion cell axon guidance	cell-cell adherens junction|integral to plasma membrane|lamellipodium|perinuclear region of cytoplasm	cadherin binding|transmembrane receptor protein tyrosine phosphatase activity			lung(3)|ovary(2)|central_nervous_system(1)	6		Colorectal(10;0.234)				CAGGGGAGGGTGGCACTGGCT	0.498		NA											28	22					0	0	0	0
C18orf55	29090	broad.mit.edu	37	18	71816193	71816193	+	Missense_Mutation	SNP	A	A	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr18:71816193A>C	uc010dqr.1	+	1	448	c.150A>C	c.(148-150)AAA>AAC	p.K50N	FBXO15_uc002lle.2_5'Flank|FBXO15_uc002llf.2_5'Flank	NM_014177	NP_054896	Q9BVV7	TI21L_HUMAN	hypothetical protein LOC29090 precursor	50					protein transport|transmembrane transport	integral to membrane|mitochondrial membrane					0		Esophageal squamous(42;0.0746)|Prostate(75;0.157)|Melanoma(33;0.211)				ATCAAAAGAAAACGCTGCGAC	0.498		NA											50	135					0	0	0	0
C18orf55	29090	broad.mit.edu	37	18	71816197	71816197	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr18:71816197C>G	uc010dqr.1	+	1	452	c.154C>G	c.(154-156)CTG>GTG	p.L52V	FBXO15_uc002lle.2_5'Flank|FBXO15_uc002llf.2_5'Flank	NM_014177	NP_054896	Q9BVV7	TI21L_HUMAN	hypothetical protein LOC29090 precursor	52					protein transport|transmembrane transport	integral to membrane|mitochondrial membrane					0		Esophageal squamous(42;0.0746)|Prostate(75;0.157)|Melanoma(33;0.211)				AAAGAAAACGCTGCGACCTAG	0.493		NA											56	135					0	0	0	0
CELF5	60680	broad.mit.edu	37	19	3282450	3282450	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:3282450C>A	uc002lxm.2	+	8	1030	c.993C>A	c.(991-993)CAC>CAA	p.H331Q	CELF5_uc002lxl.1_Missense_Mutation_p.H331Q|CELF5_uc010dtj.1_Missense_Mutation_p.H306Q|CELF5_uc010xhg.1_Missense_Mutation_p.H217Q|CELF5_uc002lxn.2_RNA	NM_021938	NP_068757	Q8N6W0	CELF5_HUMAN	bruno-like 5, RNA binding protein	331					mRNA processing	cytoplasm|nucleus	nucleotide binding|RNA binding			ovary(2)	2						CAGGTGGGCACCCTGCCCTGG	0.622		NA											13	57					1.5e-05	1.72e-05	1	0
TMEM146	257062	broad.mit.edu	37	19	5776299	5776299	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:5776299A>G	uc002mda.2	+	21	2130	c.2069A>G	c.(2068-2070)TAC>TGC	p.Y690C		NM_152784	NP_689997	Q86XM0	TM146_HUMAN	transmembrane protein 146 precursor	690	Extracellular (Potential).					integral to membrane				ovary(1)|central_nervous_system(1)|pancreas(1)	3						TATGTCTTCTACATTTCGATC	0.577		NA											23	30					0	0	0	0
FUT6	2528	broad.mit.edu	37	19	5831891	5831891	+	Missense_Mutation	SNP	G	G	T	rs364637	byFrequency	TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:5831891G>T	uc002mdf.1	-	4	1214	c.688C>A	c.(688-690)CAG>AAG	p.Q230K	FUT6_uc002mdg.1_Missense_Mutation_p.Q230K|FUT6_uc002mdh.1_Missense_Mutation_p.Q230K|FUT6_uc010dul.1_Missense_Mutation_p.Q230K	NM_001040701	NP_001035791	P51993	FUT6_HUMAN	fucosyltransferase 6	230	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity|alpha(1,3)-fucosyltransferase activity				0						ATGGTTCCCTGGGGCAGGGGC	0.612		NA											18	99					1.79e-09	2.25e-09	1	0
ZNF440	126070	broad.mit.edu	37	19	11943503	11943503	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:11943503C>G	uc002msp.1	+	4	1668	c.1512C>G	c.(1510-1512)ATC>ATG	p.I504M		NM_152357	NP_689570	Q8IYI8	ZN440_HUMAN	zinc finger protein 440	504					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CTTTTGATATCATGAAAGGAC	0.423		NA											10	29					0	0	0	0
ZNF440	126070	broad.mit.edu	37	19	11943668	11943668	+	Silent	SNP	A	A	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:11943668A>G	uc002msp.1	+	4	1833	c.1677A>G	c.(1675-1677)GAA>GAG	p.E559E		NM_152357	NP_689570	Q8IYI8	ZN440_HUMAN	zinc finger protein 440	559					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						ACACCTTTGAATACGTGGTAG	0.478		NA											6	47					0	0	0	0
ZNF700	90592	broad.mit.edu	37	19	12060260	12060260	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:12060260A>T	uc002msu.2	+	4	1547	c.1421A>T	c.(1420-1422)TAT>TTT	p.Y474F	ZNF700_uc010xme.1_Missense_Mutation_p.Y492F|ZNF763_uc010xmf.1_Intron	NM_144566	NP_653167	Q9H0M5	ZN700_HUMAN	zinc finger protein 700	474	C2H2-type 10; degenerate.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GAGAAACCCTATGAATGTAAG	0.433		NA											17	59					0	0	0	0
BEST2	54831	broad.mit.edu	37	19	12867030	12867030	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:12867030G>A	uc002mux.2	+	8	1024	c.1024G>A	c.(1024-1026)GAG>AAG	p.E342K		NM_017682	NP_060152	Q8NFU1	BEST2_HUMAN	vitelliform macular dystrophy 2-like 1	342	Cytoplasmic (Potential).				membrane depolarization|sensory perception of smell	chloride channel complex|cilium|plasma membrane	chloride channel activity			ovary(1)|pancreas(1)	2						GGATGCAGCCGAGGCTCGCGC	0.592		NA											34	158					0	0	0	0
NACC1	112939	broad.mit.edu	37	19	13247186	13247186	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:13247186G>T	uc002mwm.2	+	3	1255	c.1087G>T	c.(1087-1089)GGC>TGC	p.G363C		NM_052876	NP_443108	Q96RE7	NACC1_HUMAN	transcriptional repressor NAC1	363					negative regulation of transcription, DNA-dependent|positive regulation of cell proliferation|protein homooligomerization|transcription, DNA-dependent	cytoplasm|nuclear body					0						CTACGACGAGGGCGACCCCTC	0.647		NA											22	53					1.66e-10	2.12e-10	1	0
F2RL3	9002	broad.mit.edu	37	19	17000980	17000980	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:17000980G>T	uc002nfa.2	+	2	881	c.706G>T	c.(706-708)GCA>TCA	p.A236S		NM_003950	NP_003941	Q96RI0	PAR4_HUMAN	coagulation factor II (thrombin) receptor-like 3	236	Extracellular (Potential).				activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger|platelet activation|positive regulation of release of sequestered calcium ion into cytosol	extracellular region|integral to plasma membrane	thrombin receptor activity				0						GCCCCTGGACGCACAGGCCTC	0.706		NA											3	12					0.00909568	0.00951548	1	0
KIRREL2	84063	broad.mit.edu	37	19	36351814	36351814	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:36351814G>C	uc002ocb.3	+	8	1144	c.932G>C	c.(931-933)GGG>GCG	p.G311A	KIRREL2_uc002obz.3_Missense_Mutation_p.G311A|KIRREL2_uc002oca.3_Missense_Mutation_p.G261A|KIRREL2_uc002occ.3_Missense_Mutation_p.G258A|KIRREL2_uc002ocd.3_Missense_Mutation_p.G308A	NM_199180	NP_954649	Q6UWL6	KIRR2_HUMAN	kin of IRRE-like 2 isoform c	311	Extracellular (Potential).				cell adhesion	integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			CGTCCAGTTGGGCCGATTCTG	0.652		NA											7	23					0	0	0	0
ZNF780B	163131	broad.mit.edu	37	19	40542336	40542336	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:40542336T>C	uc002omu.2	-	5	495	c.430A>G	c.(430-432)ATC>GTC	p.I144V	ZNF780B_uc002omv.2_5'UTR	NM_001005851	NP_001005851	Q9Y6R6	Z780B_HUMAN	zinc finger protein 780B	144					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|pancreas(1)	2	all_cancers(60;9.55e-06)|all_lung(34;1.17e-07)|Lung NSC(34;1.41e-07)|Ovarian(47;0.0925)					TCATAGCTGATGATCTTCTGG	0.373		NA											8	26					0	0	0	0
SPTBN4	57731	broad.mit.edu	37	19	40978616	40978616	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:40978616C>T	uc002ony.2	+	2	174	c.88C>T	c.(88-90)CGG>TGG	p.R30W	SPTBN4_uc002onx.2_Missense_Mutation_p.R30W|SPTBN4_uc002onz.2_Missense_Mutation_p.R30W	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	30	Actin-binding.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			GAGTCCGGATCGGGGCTGGGA	0.667		NA											5	19					0	0	0	0
DMRTC2	63946	broad.mit.edu	37	19	42354396	42354396	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:42354396C>T	uc002ors.2	+	7	855	c.772C>T	c.(772-774)CTC>TTC	p.L258F	DMRTC2_uc002orr.1_Missense_Mutation_p.L135F|DMRTC2_uc010xwe.1_Missense_Mutation_p.L258F	NM_001040283	NP_001035373	Q8IXT2	DMRTD_HUMAN	DMRT-like family C2	258	Pro-rich.				cell differentiation|sex differentiation	nucleus	DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity				0						AACTCTGATACTCCAGCCCTG	0.537		NA											86	284					0	0	0	0
QPCTL	54814	broad.mit.edu	37	19	46205167	46205167	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:46205167G>A	uc010xxr.1	+	6	1219	c.998G>A	c.(997-999)CGC>CAC	p.R333H	QPCTL_uc010ekn.2_Missense_Mutation_p.R239H	NM_017659	NP_060129	Q9NXS2	QPCTL_HUMAN	glutaminyl-peptide cyclotransferase-like isoform	333					peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase|proteolysis	Golgi membrane|integral to membrane	acyltransferase activity|glutaminyl-peptide cyclotransferase activity|peptidase activity|protein binding|zinc ion binding			skin(1)	1		Ovarian(192;0.051)|all_neural(266;0.112)		OV - Ovarian serous cystadenocarcinoma(262;0.0059)|GBM - Glioblastoma multiforme(486;0.0882)|Epithelial(262;0.208)		CCCTTCCTCCGCAGAGGTACC	0.592		NA											10	61					0	0	0	0
NLRP12	91662	broad.mit.edu	37	19	54304538	54304538	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:54304538C>A	uc002qch.3	-	7	2919	c.2699G>T	c.(2698-2700)GGG>GTG	p.G900V	NLRP12_uc010eqw.2_Missense_Mutation_p.G183V|NLRP12_uc002qci.3_Missense_Mutation_p.G900V|NLRP12_uc002qcj.3_Missense_Mutation_p.G901V|NLRP12_uc002qck.3_Intron|NLRP12_uc010eqx.2_Intron	NM_144687	NP_653288	P59046	NAL12_HUMAN	NLR family, pyrin domain containing 12 isoform	900	LRR 3.				negative regulation of I-kappaB kinase/NF-kappaB cascade|negative regulation of interleukin-1 secretion|negative regulation of interleukin-6 biosynthetic process|negative regulation of protein autophosphorylation|negative regulation of Toll signaling pathway|positive regulation of inflammatory response|positive regulation of interleukin-1 beta secretion|regulation of interleukin-18 biosynthetic process|release of cytoplasmic sequestered NF-kappaB	cytoplasm	ATP binding|caspase activator activity|protein binding			ovary(4)|upper_aerodigestive_tract(2)|lung(1)	7	Ovarian(34;0.19)			GBM - Glioblastoma multiforme(134;0.026)		CAGCAGCACCCCGAGGTCCCC	0.622		NA											12	36					7.04e-09	8.73e-09	1	0
MBOAT7	79143	broad.mit.edu	37	19	54692190	54692190	+	Silent	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:54692190C>T	uc002qdq.2	-	4	353	c.87G>A	c.(85-87)CTG>CTA	p.L29L	MBOAT7_uc010erg.2_5'Flank|MBOAT7_uc010yem.1_Silent_p.L11L|MBOAT7_uc002qdr.2_Silent_p.L29L|MBOAT7_uc002qds.2_5'UTR|MBOAT7_uc010yen.1_5'UTR|MBOAT7_uc002qdt.3_Silent_p.L29L|TSEN34_uc010yeo.1_5'Flank|TSEN34_uc002qdu.2_5'Flank|TSEN34_uc002qdv.2_5'Flank|TSEN34_uc002qdw.2_5'Flank	NM_024298	NP_077274	Q96N66	MBOA7_HUMAN	membrane bound O-acyltransferase domain	29	Helical; (Potential).				phospholipid biosynthetic process	integral to membrane	acyltransferase activity				0	all_cancers(19;0.0065)|all_epithelial(19;0.00348)|all_lung(19;0.0175)|Lung NSC(19;0.0325)|Ovarian(34;0.19)					CCCATCTCTTCAGCCCAGGAC	0.642		NA											9	18					0	0	0	0
NLRP7	199713	broad.mit.edu	37	19	55446005	55446005	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:55446005G>T	uc002qih.3	-	7	2399	c.2323C>A	c.(2323-2325)CCG>ACG	p.P775T	NLRP7_uc002qig.3_Missense_Mutation_p.P747T|NLRP7_uc002qii.3_Missense_Mutation_p.P775T|NLRP7_uc010esk.2_Missense_Mutation_p.P775T|NLRP7_uc010esl.2_Missense_Mutation_p.P803T	NM_206828	NP_996611	Q8WX94	NALP7_HUMAN	NACHT, leucine rich repeat and PYD containing 7	775	LRR 3.						ATP binding			large_intestine(1)|breast(1)|central_nervous_system(1)	3				GBM - Glioblastoma multiforme(193;0.0325)		CACTGCTCCGGGGTGGCACAG	0.478		NA											13	32					0.000219431	0.000244612	1	0
UBE2S	27338	broad.mit.edu	37	19	55915802	55915802	+	Silent	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:55915802G>A	uc002qkx.1	-	3	564	c.196C>T	c.(196-198)CTG>TTG	p.L66L		NM_014501	NP_055316	Q16763	UBE2S_HUMAN	ubiquitin-conjugating enzyme E2S	66					activation of anaphase-promoting complex activity|anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|exit from mitosis|free ubiquitin chain polymerization|protein K11-linked ubiquitination|protein K27-linked ubiquitination|protein K29-linked ubiquitination|protein K6-linked ubiquitination|protein K63-linked ubiquitination	anaphase-promoting complex	ATP binding|ubiquitin-protein ligase activity				0	Breast(117;0.155)		LUSC - Lung squamous cell carcinoma(43;0.13)|BRCA - Breast invasive adenocarcinoma(297;0.209)	GBM - Glioblastoma multiforme(193;0.11)		TCCTTCCCCAGCAGGAGTTTC	0.612		NA											11	18					0	0	0	0
NLRP8	126205	broad.mit.edu	37	19	56459511	56459511	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:56459511G>T	uc002qmh.2	+	1	314	c.243G>T	c.(241-243)TGG>TGT	p.W81C	NLRP8_uc010etg.2_Missense_Mutation_p.W81C	NM_176811	NP_789781	Q86W28	NALP8_HUMAN	NLR family, pyrin domain containing 8	81	DAPIN.					cytoplasm	ATP binding			ovary(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|kidney(1)	13		Colorectal(82;0.000147)|Ovarian(87;0.17)		GBM - Glioblastoma multiforme(193;0.0695)		CAGCCAGCTGGGCAGAGGTGG	0.522		NA											8	22					0.000157383	0.000175665	1	0
ZNF582	147948	broad.mit.edu	37	19	56901748	56901748	+	Silent	SNP	T	T	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:56901748T>C	uc002qmz.1	-	3	291	c.132A>G	c.(130-132)TCA>TCG	p.S44S	ZNF582_uc002qmy.2_Silent_p.S75S	NM_144690	NP_653291	Q96NG8	ZN582_HUMAN	zinc finger protein 582	44	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(3)|large_intestine(1)	4		Colorectal(82;0.000256)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0547)		CCTTACCCAGTGAGACCAGGT	0.488		NA											28	90					0	0	0	0
PEG3	5178	broad.mit.edu	37	19	57327096	57327096	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:57327096T>A	uc002qnu.2	-	7	3065	c.2714A>T	c.(2713-2715)CAG>CTG	p.Q905L	ZIM2_uc010ygq.1_Intron|ZIM2_uc010ygr.1_Intron|ZIM2_uc002qnr.2_Intron|ZIM2_uc002qnq.2_Intron|ZIM2_uc010etp.2_Intron|ZIM2_uc010ygs.1_Intron|PEG3_uc002qnt.2_Missense_Mutation_p.Q876L|PEG3_uc002qnv.2_Missense_Mutation_p.Q905L|PEG3_uc002qnw.2_Missense_Mutation_p.Q781L|PEG3_uc002qnx.2_Missense_Mutation_p.Q779L|PEG3_uc010etr.2_Missense_Mutation_p.Q905L	NM_001146186	NP_001139658	Q9GZU2	PEG3_HUMAN	paternally expressed 3 isoform 1	905					apoptosis|viral reproduction	cytoplasm|nucleus	nucleic acid binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(7)|skin(2)|upper_aerodigestive_tract(1)|large_intestine(1)|pancreas(1)	12		Colorectal(82;0.000256)|all_neural(62;0.103)|Ovarian(87;0.243)		GBM - Glioblastoma multiforme(193;0.0269)		AACACTTTTCTGAGGTTTGGC	0.478		NA											13	73					0	0	0	0
ZIM3	114026	broad.mit.edu	37	19	57646302	57646302	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:57646302C>A	uc002qnz.1	-	5	1789	c.1403G>T	c.(1402-1404)AGA>ATA	p.R468I		NM_052882	NP_443114	Q96PE6	ZIM3_HUMAN	zinc finger, imprinted 3	468	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)|skin(1)	2		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.243)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		GGAGTGAATTCTTTTCTGGTG	0.423		NA											26	85					3.99e-17	5.51e-17	1	0
ZNF530	348327	broad.mit.edu	37	19	58117342	58117342	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:58117342G>T	uc002qpk.2	+	3	669	c.449G>T	c.(448-450)GGG>GTG	p.G150V	ZNF547_uc002qpm.3_Intron|ZNF530_uc002qpl.2_RNA	NM_020880	NP_065931	Q6P9A1	ZN530_HUMAN	zinc finger protein 530	150					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Colorectal(82;5.46e-05)|all_neural(62;0.0218)|Ovarian(87;0.0443)|Breast(46;0.0848)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0257)		AAAGTGGATGGGGACCAGGCC	0.473		NA											14	54					1.58e-08	1.95e-08	1	0
ZNF329	79673	broad.mit.edu	37	19	58639938	58639938	+	Silent	SNP	C	C	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr19:58639938C>G	uc002qrn.2	-	4	1170	c.933G>C	c.(931-933)GGG>GGC	p.G311G	ZNF329_uc010euk.1_RNA|ZNF329_uc002qro.1_RNA|ZNF329_uc002qrp.1_RNA	NM_024620	NP_078896	Q86UD4	ZN329_HUMAN	zinc finger protein 329	311					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			skin(1)	1		Colorectal(82;5.46e-05)|all_neural(62;0.0182)|Breast(46;0.029)|Ovarian(87;0.0443)|Renal(1328;0.157)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.017)|Lung(386;0.216)		ATGGTTTTTCCCCTGTATGAG	0.433		NA											41	108					0	0	0	0
APOB	338	broad.mit.edu	37	2	21234732	21234732	+	Nonsense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:21234732C>A	uc002red.2	-	26	5136	c.5008G>T	c.(5008-5010)GAG>TAG	p.E1670*		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	1670				E -> D (in Ref. 8; AAA51752).	cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	GCATTCAGCTCATTCTCCAGC	0.473		NA											10	44					0.000442599	0.000487245	1	0
SLC8A1	6546	broad.mit.edu	37	2	40656161	40656161	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:40656161C>G	uc002rrx.2	-	1	1284	c.1260G>C	c.(1258-1260)GAG>GAC	p.E420D	SLC8A1_uc002rry.2_Missense_Mutation_p.E420D|SLC8A1_uc002rrz.2_Missense_Mutation_p.E420D|SLC8A1_uc002rsa.2_Missense_Mutation_p.E420D|SLC8A1_uc002rsd.3_Missense_Mutation_p.E420D|SLC8A1_uc002rsb.1_Missense_Mutation_p.E420D|SLC8A1_uc010fan.1_Missense_Mutation_p.E420D|SLC8A1_uc002rsc.1_Missense_Mutation_p.E420D	NM_021097	NP_066920	P32418	NAC1_HUMAN	solute carrier family 8 (sodium/calcium	420	Calx-beta 1.|Cytoplasmic (Potential).				cell communication|muscle contraction|platelet activation	integral to plasma membrane	calcium:sodium antiporter activity|calmodulin binding|heat shock protein binding			ovary(1)|kidney(1)|central_nervous_system(1)|skin(1)	4					Alpha-Linolenic Acid(DB00132)|Icosapent(DB00159)	TACCACAGTTCTCCAGACACT	0.463		NA											19	36					0	0	0	0
EML4	27436	broad.mit.edu	37	2	42472706	42472706	+	Silent	SNP	A	A	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:42472706A>G	uc002rsi.2	+	2	349	c.87A>G	c.(85-87)TCA>TCG	p.S29S	EML4_uc002rsh.3_Silent_p.S29S|EML4_uc010fap.2_Silent_p.S29S	NM_019063	NP_061936	Q9HC35	EMAL4_HUMAN	echinoderm microtubule associated protein like 4	29					microtubule-based process|mitosis	cytoplasm|microtubule	protein binding		EML4/ALK(246)	lung(246)|ovary(2)|central_nervous_system(1)|skin(1)	250						CTCTTGAGTCACGAGTTCAGC	0.383		NA	T	ALK	NSCLC								12	35					0	0	0	0
CCDC85A	114800	broad.mit.edu	37	2	56420144	56420144	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:56420144G>T	uc002rzn.2	+	2	1311	c.809G>T	c.(808-810)CGC>CTC	p.R270L		NM_001080433	NP_001073902	Q96PX6	CC85A_HUMAN	coiled-coil domain containing 85A	270	His-rich.									breast(3)|ovary(2)	5			LUSC - Lung squamous cell carcinoma(58;0.127)|Lung(47;0.132)			ACCCCAGATCGCCCCAAAGCA	0.652		NA											17	56					1.63e-17	2.26e-17	1	0
AFF3	3899	broad.mit.edu	37	2	100210155	100210155	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:100210155G>T	uc002tag.2	-	14	2204	c.1968C>A	c.(1966-1968)AGC>AGA	p.S656R	AFF3_uc002taf.2_Missense_Mutation_p.S681R|AFF3_uc010fiq.1_Missense_Mutation_p.S656R|AFF3_uc010yvr.1_Missense_Mutation_p.S809R|AFF3_uc002tah.1_Missense_Mutation_p.S681R	NM_002285	NP_002276	P51826	AFF3_HUMAN	AF4/FMR2 family, member 3 isoform 1	656					multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)|pancreas(1)|lung(1)|kidney(1)|skin(1)	6						GGACGATCCTGCTTAGCCCCC	0.617		NA											40	106					4.41e-31	6.34e-31	1	0
CCDC138	165055	broad.mit.edu	37	2	109473416	109473416	+	Silent	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:109473416G>T	uc002ten.1	+	13	1743	c.1683G>T	c.(1681-1683)ACG>ACT	p.T561T	CCDC138_uc002teo.1_Silent_p.T561T|CCDC138_uc002tep.1_Silent_p.T245T|CCDC138_uc010fjm.1_Silent_p.T245T	NM_144978	NP_659415	Q96M89	CC138_HUMAN	coiled-coil domain containing 138	561											0						TCCAGATGACGGTGGAATCTA	0.343		NA											16	41					2.32e-09	2.91e-09	1	0
GPR17	2840	broad.mit.edu	37	2	128409254	128409254	+	Silent	SNP	A	A	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:128409254A>G	uc010yzn.1	+	4	1640	c.1029A>G	c.(1027-1029)AAA>AAG	p.K343K	LIMS2_uc002tox.2_Intron|LIMS2_uc010fmb.2_Intron|LIMS2_uc002toy.2_Intron|LIMS2_uc010yzm.1_Intron|LIMS2_uc002tpa.2_Intron|LIMS2_uc002toz.2_Intron|LIMS2_uc002tpb.2_Intron|GPR17_uc002tpc.2_Silent_p.K343K|GPR17_uc010yzo.1_Silent_p.K315K|GPR17_uc002tpd.2_Silent_p.K315K	NM_001161415	NP_001154887	Q13304	GPR17_HUMAN	G protein-coupled receptor 17 isoform a	343	Cytoplasmic (Potential).					integral to plasma membrane	chemokine receptor activity|purinergic nucleotide receptor activity, G-protein coupled				0	Colorectal(110;0.1)	Ovarian(717;0.15)		BRCA - Breast invasive adenocarcinoma(221;0.0677)		TCTGTGGCAAAAGGCTCAAGG	0.632		NA											26	81					0	0	0	0
THSD7B	80731	broad.mit.edu	37	2	138169330	138169330	+	Silent	SNP	A	A	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:138169330A>C	uc002tva.1	+	13	2754	c.2754A>C	c.(2752-2754)GGA>GGC	p.G918G	THSD7B_uc010zbj.1_Intron|THSD7B_uc002tvb.2_Silent_p.G808G	NM_001080427	NP_001073896			thrombospondin, type I, domain containing 7B											ovary(4)|central_nervous_system(2)|pancreas(1)	7				BRCA - Breast invasive adenocarcinoma(221;0.19)		CTCACCGAGGACTGCGGGTAC	0.483		NA											19	61					0	0	0	0
EPC2	26122	broad.mit.edu	37	2	149447814	149447814	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:149447814A>G	uc010zbt.1	+	2	212	c.185A>G	c.(184-186)CAG>CGG	p.Q62R		NM_015630	NP_056445	Q52LR7	EPC2_HUMAN	enhancer of polycomb homolog 2	62					chromatin modification|DNA repair|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus				ovary(1)|breast(1)|pancreas(1)	3				BRCA - Breast invasive adenocarcinoma(221;0.0516)		ATTTCAGCACAGCAAGTGTTT	0.333		NA											13	25					0	0	0	0
CYTIP	9595	broad.mit.edu	37	2	158272443	158272443	+	Silent	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:158272443G>T	uc002tzj.1	-	8	898	c.826C>A	c.(826-828)CGG>AGG	p.R276R	CYTIP_uc010zcl.1_Silent_p.R170R	NM_004288	NP_004279	O60759	CYTIP_HUMAN	cytohesin 1 interacting protein	276	Ser-rich.				regulation of cell adhesion	cell cortex|early endosome	protein binding			ovary(1)|kidney(1)|skin(1)	3						CTCGTCTGCCGACTGAAGGCA	0.537		NA											16	43					9.17e-09	1.13e-08	1	0
PLA2R1	22925	broad.mit.edu	37	2	160833232	160833232	+	Splice_Site	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:160833232C>T	uc002ube.1	-	16	2609	c.2402_splice	c.e16-1	p.D801_splice	PLA2R1_uc010zcp.1_Splice_Site_p.D801_splice|PLA2R1_uc002ubf.2_Splice_Site_p.D801_splice	NM_007366	NP_031392	Q13018	PLA2R_HUMAN	phospholipase A2 receptor 1 isoform 1 precursor						endocytosis	extracellular space|integral to plasma membrane	receptor activity|sugar binding			skin(2)|ovary(1)	3						GGTTTCACATCTGCAAAGTGA	0.358		NA											6	26					0	0	0	0
FAP	2191	broad.mit.edu	37	2	163027570	163027570	+	Silent	SNP	G	G	A	rs138589105	byFrequency	TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:163027570G>A	uc002ucd.2	-	26	2410	c.2202C>T	c.(2200-2202)CAC>CAT	p.H734H	FAP_uc010fpc.2_Silent_p.H283H|FAP_uc010zct.1_Silent_p.H709H|FAP_uc010fpd.2_Silent_p.H213H	NM_004460	NP_004451	Q12884	SEPR_HUMAN	fibroblast activation protein, alpha subunit	734	Extracellular (Potential).	Charge relay system.			endothelial cell migration|negative regulation of extracellular matrix disassembly|proteolysis	cell junction|integral to membrane|invadopodium membrane|lamellipodium membrane	dipeptidyl-peptidase activity|metalloendopeptidase activity|protein homodimerization activity|serine-type endopeptidase activity			ovary(3)	3						CGGATAAGCCGTGGTTCTGGT	0.438		NA											28	66					0	0	0	0
SCN2A	6326	broad.mit.edu	37	2	166245537	166245537	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:166245537T>A	uc002udc.2	+	27	5511	c.5221T>A	c.(5221-5223)TCA>ACA	p.S1741T	SCN2A_uc002udd.2_Missense_Mutation_p.S1741T|SCN2A_uc002ude.2_Missense_Mutation_p.S1741T	NM_001040142	NP_001035232	Q99250	SCN2A_HUMAN	sodium channel, voltage-gated, type II, alpha	1741	IV.				myelination	node of Ranvier|voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|breast(1)|pancreas(1)	8					Lamotrigine(DB00555)	CCCTGGAAGCTCAGTTAAAGG	0.458		NA											47	135					0	0	0	0
LRP2	4036	broad.mit.edu	37	2	169999284	169999284	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:169999284C>A	uc002ues.2	-	71	13221	c.13008G>T	c.(13006-13008)CAG>CAT	p.Q4336H		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	4336	EGF-like 16.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GGCTGCAGATCTGTTTGCAAA	0.537		NA											14	54					6.32e-08	7.67e-08	1	0
HOXD10	3236	broad.mit.edu	37	2	176981826	176981826	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:176981826C>G	uc002ukj.2	+	1	335	c.265C>G	c.(265-267)CGA>GGA	p.R89G		NM_002148	NP_002139	P28358	HXD10_HUMAN	homeobox D10	89						nucleus	sequence-specific DNA binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.0207)|Epithelial(96;0.18)	Colorectal(32;0.0226)|READ - Rectum adenocarcinoma(9;0.0556)		CAGATCTTGTCGAATAGAGCA	0.433		NA											24	71					0	0	0	0
TTN	7273	broad.mit.edu	37	2	179588653	179588653	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:179588653C>T	uc010zfg.1	-	70	17825	c.17601G>A	c.(17599-17601)ATG>ATA	p.M5867I	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.M2528I	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	6794							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TGTAATTGCCCATATCTGAGG	0.423		NA											11	38					0	0	0	0
ZNF804A	91752	broad.mit.edu	37	2	185800594	185800594	+	Silent	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:185800594G>T	uc002uph.2	+	4	1065	c.471G>T	c.(469-471)GTG>GTT	p.V157V		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	157						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						GAGTTGTTGTGGATTCAGTTA	0.383		NA											7	36					2.77e-08	3.38e-08	1	0
ZNF804A	91752	broad.mit.edu	37	2	185803491	185803491	+	Missense_Mutation	SNP	A	A	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:185803491A>C	uc002uph.2	+	4	3962	c.3368A>C	c.(3367-3369)AAA>ACA	p.K1123T		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	1123						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						gGAACCTTTAAAGTGCTTCAG	0.343		NA											12	58					0	0	0	0
SLC39A10	57181	broad.mit.edu	37	2	196578254	196578254	+	Nonsense_Mutation	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:196578254G>A	uc002utg.3	+	6	1887	c.1673G>A	c.(1672-1674)TGG>TAG	p.W558*	SLC39A10_uc002uth.3_Nonsense_Mutation_p.W558*|SLC39A10_uc010zgp.1_Nonsense_Mutation_p.W108*	NM_001127257	NP_001120729	Q9ULF5	S39AA_HUMAN	solute carrier family 39 (zinc transporter),	558					zinc ion transport	integral to membrane	metal ion transmembrane transporter activity			pancreas(1)|skin(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.221)			GATTCTGACTGGCTTCAACTC	0.323		NA											13	22					0	0	0	0
DNAH7	56171	broad.mit.edu	37	2	196765106	196765106	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:196765106G>C	uc002utj.3	-	28	4549	c.4448C>G	c.(4447-4449)GCT>GGT	p.A1483G		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1483	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						GCGATACGTAGCCACAATTTT	0.458		NA											32	123					0	0	0	0
DNAH7	56171	broad.mit.edu	37	2	196765116	196765116	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:196765116T>C	uc002utj.3	-	28	4539	c.4438A>G	c.(4438-4440)AAA>GAA	p.K1480E		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1480	AAA 1 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						GCCACAATTTTTACAGACAGT	0.463		NA											37	122					0	0	0	0
HECW2	57520	broad.mit.edu	37	2	197183378	197183378	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:197183378C>T	uc002utm.1	-	9	2419	c.2236G>A	c.(2236-2238)GCT>ACT	p.A746T	HECW2_uc002utl.1_Missense_Mutation_p.A390T	NM_020760	NP_065811	Q9P2P5	HECW2_HUMAN	HECT, C2 and WW domain containing E3 ubiquitin	746	Interaction with TP73.				protein ubiquitination involved in ubiquitin-dependent protein catabolic process	cytoplasm	ubiquitin-protein ligase activity			skin(5)|ovary(5)|lung(4)|pancreas(2)|central_nervous_system(1)|kidney(1)	18						GCAGCTGCAGCTCCCTCCAGG	0.682		NA											13	41					0	0	0	0
MOGAT1	116255	broad.mit.edu	37	2	223554124	223554124	+	Silent	SNP	A	A	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:223554124A>T	uc010fws.1	+	3	462	c.414A>T	c.(412-414)TCA>TCT	p.S138S	MOGAT1_uc010fwt.1_Silent_p.S98S	NM_058165	NP_477513	Q96PD6	MOGT1_HUMAN	monoacylglycerol O-acyltransferase 1	138	Helical; (Potential).				glycerol metabolic process	endoplasmic reticulum membrane|integral to membrane	2-acylglycerol O-acyltransferase activity			breast(1)	1		Renal(207;0.0183)		Epithelial(121;4.13e-10)|all cancers(144;2.06e-07)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0105)		GCTTTACTTCATATCTTCACG	0.428		NA											17	73					0	0	0	0
COL4A3	1285	broad.mit.edu	37	2	228169782	228169782	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:228169782G>A	uc002vom.1	+	47	4397	c.4235G>A	c.(4234-4236)GGT>GAT	p.G1412D	COL4A3_uc002von.1_Missense_Mutation_p.G1412D|COL4A3_uc002voo.1_Missense_Mutation_p.G1412D|COL4A3_uc002vop.1_Missense_Mutation_p.G1412D|uc002voq.1_Intron|uc002vor.1_Intron|COL4A3_uc010fxf.1_5'Flank	NM_000091	NP_000082	Q01955	CO4A3_HUMAN	alpha 3 type IV collagen isoform 1 precursor	1412	Triple-helical region.				activation of caspase activity|axon guidance|blood circulation|cell adhesion|cell proliferation|cell surface receptor linked signaling pathway|glomerular basement membrane development|induction of apoptosis|negative regulation of angiogenesis|negative regulation of cell proliferation|sensory perception of sound	collagen type IV	extracellular matrix structural constituent|integrin binding|metalloendopeptidase inhibitor activity			skin(2)|ovary(1)	3		all_lung(227;0.00101)|Lung NSC(271;0.00278)|Renal(207;0.0112)|Ovarian(221;0.0129)|all_hematologic(139;0.211)|Esophageal squamous(248;0.247)		Epithelial(121;1.17e-46)|all cancers(144;6.87e-42)|Lung(261;0.0137)|LUSC - Lung squamous cell carcinoma(224;0.0187)		GGCAACAAAGGTTCTAAAGGA	0.488		NA											7	17					0	0	0	0
SLC19A3	80704	broad.mit.edu	37	2	228563763	228563763	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:228563763C>A	uc002vpi.2	-	3	757	c.668G>T	c.(667-669)GGT>GTT	p.G223V	SLC19A3_uc002vpj.2_RNA|SLC19A3_uc010zlv.1_Missense_Mutation_p.G219V	NM_025243	NP_079519	Q9BZV2	S19A3_HUMAN	solute carrier family 19, member 3	223	Cytoplasmic (Potential).				thiamine-containing compound metabolic process	integral to membrane|plasma membrane	folic acid binding|reduced folate carrier activity|thiamine uptake transmembrane transporter activity			ovary(2)	2		Renal(207;0.0112)|all_lung(227;0.0335)|Lung NSC(271;0.142)|all_hematologic(139;0.21)|Esophageal squamous(248;0.236)		Epithelial(121;1.58e-10)|all cancers(144;8.55e-08)|Lung(261;0.00948)|LUSC - Lung squamous cell carcinoma(224;0.0125)	L-Cysteine(DB00151)	TGGTGCTTCACCTTCGTGAGT	0.448		NA											15	40					0.000308642	0.000340199	1	0
CCL20	6364	broad.mit.edu	37	2	228681044	228681044	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:228681044G>T	uc002vpl.2	+	3	283	c.213G>T	c.(211-213)TTG>TTT	p.L71F	CCL20_uc002vpm.2_Missense_Mutation_p.L70F	NM_004591	NP_004582	P78556	CCL20_HUMAN	chemokine (C-C motif) ligand 20 isoform 1	71					cell-cell signaling|chemotaxis|defense response to bacterium|immune response|inflammatory response|signal transduction	extracellular space	chemokine activity				0		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;7.3e-11)|all cancers(144;4.13e-08)|Lung(261;0.00942)|LUSC - Lung squamous cell carcinoma(224;0.0115)		AGAAAAAGTTGTCTGTGTGCG	0.338		NA											18	31					3.6e-14	4.83e-14	1	0
SPHKAP	80309	broad.mit.edu	37	2	228855881	228855881	+	Silent	SNP	A	A	T	rs137978320	byFrequency	TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:228855881A>T	uc002vpq.2	-	11	4841	c.4794T>A	c.(4792-4794)CCT>CCA	p.P1598P	SPHKAP_uc002vpp.2_Silent_p.P1569P|SPHKAP_uc010zlx.1_Intron	NM_001142644	NP_001136116	Q2M3C7	SPKAP_HUMAN	sphingosine kinase type 1-interacting protein	1598						cytoplasm	protein binding			skin(5)|ovary(4)|lung(1)	10		Renal(207;0.025)|all_hematologic(139;0.15)|all_lung(227;0.204)|Acute lymphoblastic leukemia(138;0.205)|Esophageal squamous(248;0.23)		Epithelial(121;8.17e-11)|all cancers(144;7.92e-08)|Lung(261;0.0168)|LUSC - Lung squamous cell carcinoma(224;0.0232)		CTGTTCCCGTAGGCGGTCCAG	0.562		NA											10	40					0	0	0	0
ALPPL2	251	broad.mit.edu	37	2	233273006	233273006	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:233273006G>T	uc002vss.3	+	6	731	c.678G>T	c.(676-678)ATG>ATT	p.M226I		NM_031313	NP_112603	P10696	PPBN_HUMAN	placental-like alkaline phosphatase	226					phosphorylation	anchored to membrane|plasma membrane	alkaline phosphatase activity|metal ion binding			skin(1)	1		all_hematologic(139;0.00793)|Renal(207;0.0112)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0449)|Lung NSC(271;0.132)		Epithelial(121;4.45e-22)|Kidney(3;4.42e-11)|KIRC - Kidney renal clear cell carcinoma(3;1.9e-09)|BRCA - Breast invasive adenocarcinoma(100;0.000767)|Lung(119;0.00566)|LUSC - Lung squamous cell carcinoma(224;0.00746)|STAD - Stomach adenocarcinoma(3;0.0181)|GBM - Glioblastoma multiforme(43;0.196)	Amifostine(DB01143)|Levamisole(DB00848)	GAAAGTACATGTTTCCCATGG	0.617		NA											21	98					2.22e-12	2.9e-12	1	0
SIRPA	140885	broad.mit.edu	37	20	1918052	1918052	+	Silent	SNP	G	G	T	rs149536101	by1000genomes	TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr20:1918052G>T	uc002wfq.2	+	9	1713	c.1353G>T	c.(1351-1353)ACG>ACT	p.T451T	SIRPA_uc010zps.1_Silent_p.T431T|SIRPA_uc002wfr.2_Silent_p.T451T|SIRPA_uc002wfs.2_Silent_p.T451T|SIRPA_uc002wft.2_Silent_p.T455T	NM_001040022	NP_001035111	P78324	SHPS1_HUMAN	signal-regulatory protein alpha precursor	451	Cytoplasmic (Potential).				blood coagulation|cell adhesion|cell junction assembly|leukocyte migration	integral to membrane|plasma membrane	SH3 domain binding			ovary(1)	1				Colorectal(46;0.018)|READ - Rectum adenocarcinoma(1;0.0556)		ACAACCACACGGAGTATGCCA	0.582		NA											17	61					3.33e-07	3.97e-07	1	0
C20orf26	26074	broad.mit.edu	37	20	20177327	20177327	+	Silent	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr20:20177327G>A	uc002wru.2	+	16	1780	c.1704G>A	c.(1702-1704)CGG>CGA	p.R568R	C20orf26_uc010zse.1_Silent_p.R548R	NM_015585	NP_056400	Q8NHU2	CT026_HUMAN	hypothetical protein LOC26074	568										ovary(3)|pancreas(1)	4				READ - Rectum adenocarcinoma(2;0.171)		CCATTTTCCGGCACTACACCA	0.468		NA											53	69					0	0	0	0
KIAA1755	85449	broad.mit.edu	37	20	36869162	36869162	+	Silent	SNP	A	A	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr20:36869162A>G	uc002xhy.1	-	3	1643	c.1371T>C	c.(1369-1371)CCT>CCC	p.P457P	KIAA1755_uc002xhz.1_Silent_p.P457P	NM_001029864	NP_001025035	Q5JYT7	K1755_HUMAN	hypothetical protein LOC85449	457										ovary(4)|pancreas(1)	5		Myeloproliferative disorder(115;0.00874)				TGTTTCTGCTAGGGCAGGGCA	0.572		NA											21	70					0	0	0	0
ZFP64	55734	broad.mit.edu	37	20	50776766	50776766	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr20:50776766T>C	uc002xwl.2	-	5	1008	c.659A>G	c.(658-660)AAG>AGG	p.K220R	ZFP64_uc002xwk.2_Missense_Mutation_p.K220R|ZFP64_uc002xwm.2_Missense_Mutation_p.K218R|ZFP64_uc002xwn.2_Missense_Mutation_p.K166R	NM_018197	NP_060667	Q9NPA5	ZF64A_HUMAN	zinc finger protein 64 isoform a	220	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2						CCTCAGGTGCTTGTTGAGGCT	0.597		NA											45	115					0	0	0	0
ZNF217	7764	broad.mit.edu	37	20	52198454	52198454	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr20:52198454T>A	uc002xwq.3	-	1	1183	c.912A>T	c.(910-912)AAA>AAT	p.K304N	ZNF217_uc010gij.1_Missense_Mutation_p.K296N	NM_006526	NP_006517	O75362	ZN217_HUMAN	zinc finger protein 217	304					negative regulation of transcription, DNA-dependent	histone deacetylase complex	protein binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|zinc ion binding			skin(2)|ovary(1)|large_intestine(1)|lung(1)|breast(1)	6	all_cancers(1;6.75e-17)|all_epithelial(1;1.76e-18)|Breast(2;3.83e-14)|Lung NSC(4;9.04e-07)|all_lung(4;2.5e-06)|Ovarian(1;0.0398)		BRCA - Breast invasive adenocarcinoma(1;9.88e-17)|Epithelial(1;1.56e-14)|all cancers(1;9.44e-13)|STAD - Stomach adenocarcinoma(23;0.0474)|Colorectal(105;0.198)			CAACTTTTCCTTTGGTAGCCA	0.517		NA											57	128					0	0	0	0
BCAS1	8537	broad.mit.edu	37	20	52612559	52612559	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr20:52612559G>T	uc002xws.2	-	5	1092	c.754C>A	c.(754-756)CAA>AAA	p.Q252K	BCAS1_uc010zza.1_5'UTR|BCAS1_uc010zzb.1_Missense_Mutation_p.Q155K|BCAS1_uc010gim.2_Missense_Mutation_p.Q155K|BCAS1_uc002xwt.2_Missense_Mutation_p.Q252K|BCAS1_uc010gil.1_Missense_Mutation_p.Q252K	NM_003657	NP_003648	O75363	BCAS1_HUMAN	breast carcinoma amplified sequence 1	252						cytoplasm	protein binding			ovary(2)|central_nervous_system(1)	3	Breast(2;9.53e-15)|Lung NSC(4;5.57e-06)|all_lung(4;1.44e-05)		STAD - Stomach adenocarcinoma(23;0.116)|Colorectal(105;0.198)			CCAAGTTCTTGTCCTTCTTTT	0.473		NA											20	60					7.42e-09	9.19e-09	1	0
PRIC285	85441	broad.mit.edu	37	20	62191627	62191627	+	Silent	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr20:62191627G>A	uc002yfm.2	-	18	8446	c.7554C>T	c.(7552-7554)ATC>ATT	p.I2518I	PRIC285_uc002yfl.1_Silent_p.I1949I	NM_001037335	NP_001032412	Q9BYK8	PR285_HUMAN	PPAR-alpha interacting complex protein 285	2518					cellular lipid metabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	ATP binding|DNA binding|helicase activity|ribonuclease activity|RNA binding|transcription coactivator activity|zinc ion binding			central_nervous_system(2)	2	all_cancers(38;2.51e-11)|all_epithelial(29;8.27e-13)		Epithelial(9;1.27e-08)|all cancers(9;7.32e-08)|BRCA - Breast invasive adenocarcinoma(10;5.15e-06)			TGAGGACGGCGATGTCCTGGG	0.672		NA											4	7					0	0	0	0
MORC3	23515	broad.mit.edu	37	21	37741308	37741308	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr21:37741308C>G	uc002yvi.2	+	15	1718	c.1642C>G	c.(1642-1644)CGT>GGT	p.R548G		NM_015358	NP_056173	Q14149	MORC3_HUMAN	MORC family CW-type zinc finger 3	548					cell aging|maintenance of protein location in nucleus|negative regulation of fibroblast proliferation|peptidyl-serine phosphorylation|protein stabilization	aggresome|intermediate filament cytoskeleton|PML body	ATP binding|zinc ion binding			ovary(2)	2						ACTTTCTACTCGTTCCTCAAT	0.299		NA											9	23					0	0	0	0
HPS4	89781	broad.mit.edu	37	22	26873050	26873050	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr22:26873050C>A	uc003acl.2	-	4	844	c.185G>T	c.(184-186)CGC>CTC	p.R62L	HPS4_uc003aci.2_Missense_Mutation_p.R57L|HPS4_uc003acj.2_5'UTR|HPS4_uc003ack.2_5'UTR|HPS4_uc003acn.2_5'UTR|HPS4_uc010gvd.1_Missense_Mutation_p.R62L|HPS4_uc003aco.1_Missense_Mutation_p.R57L	NM_022081	NP_071364	Q9NQG7	HPS4_HUMAN	light ear protein isoform a	62					lysosome organization|positive regulation of eye pigmentation|protein stabilization|protein targeting	lysosome|melanosome|membrane fraction|platelet dense granule	protein homodimerization activity				0						AGAAACACAGCGGACAACTCC	0.443		NA							Hermansky-Pudlak_syndrome				17	48					2.23e-06	2.62e-06	1	0
SLC5A4	6527	broad.mit.edu	37	22	32643427	32643427	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr22:32643427G>T	uc003ami.2	-	5	450	c.448C>A	c.(448-450)CTC>ATC	p.L150I		NM_014227	NP_055042	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (low affinity glucose	150	Extracellular (Potential).				carbohydrate transport|sodium ion transport	integral to membrane	symporter activity				0						CAGATGAAGAGGGAGAGGATG	0.498		NA											10	41					7.48e-07	8.88e-07	1	0
GRAMD4	23151	broad.mit.edu	37	22	47062734	47062734	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr22:47062734A>G	uc003bhx.2	+	9	861	c.822A>G	c.(820-822)ATA>ATG	p.I274M	GRAMD4_uc010had.2_Missense_Mutation_p.I213M	NM_015124	NP_055939	Q6IC98	GRAM4_HUMAN	death-inducing-protein	274					apoptosis	integral to membrane|mitochondrial membrane				ovary(1)	1		Breast(42;0.00571)|Ovarian(80;0.00965)|all_neural(38;0.0416)		UCEC - Uterine corpus endometrioid carcinoma (28;0.0178)|BRCA - Breast invasive adenocarcinoma(115;0.166)		GGTGGCGGATACAGTGGAGCA	0.622		NA											35	90					0	0	0	0
SBF1	6305	broad.mit.edu	37	22	50893510	50893510	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr22:50893510T>C	uc003blh.2	-	34	4811	c.4616A>G	c.(4615-4617)TAC>TGC	p.Y1539C	SBF1_uc003ble.2_Missense_Mutation_p.Y15C|SBF1_uc003blf.2_Missense_Mutation_p.Y15C|SBF1_uc011arx.1_Missense_Mutation_p.Y1177C	NM_002972	NP_002963	O95248	MTMR5_HUMAN	SET binding factor 1	1513	Myotubularin phosphatase.				protein dephosphorylation	integral to membrane|nucleus	protein tyrosine/serine/threonine phosphatase activity				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.206)|LUAD - Lung adenocarcinoma(64;0.247)		CACATGGTGGTAGCCGAGGAA	0.622		NA											16	34					0	0	0	0
CHL1	10752	broad.mit.edu	37	3	432410	432410	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:432410G>T	uc003bou.2	+	20	2720	c.2449G>T	c.(2449-2451)GGG>TGG	p.G817W	CHL1_uc003bot.2_Missense_Mutation_p.G833W|CHL1_uc003bow.1_Missense_Mutation_p.G817W|CHL1_uc011asi.1_Missense_Mutation_p.G833W	NM_006614	NP_006605	O00533	CHL1_HUMAN	cell adhesion molecule with homology to L1CAM	817	Fibronectin type-III 3.|Extracellular (Potential).				axon guidance|cell adhesion|signal transduction	integral to membrane|plasma membrane|proteinaceous extracellular matrix				skin(5)|central_nervous_system(4)|large_intestine(2)|ovary(1)	12		all_cancers(2;1.14e-06)|all_epithelial(2;0.00367)|all_lung(1;0.061)|Lung NSC(2;0.201)		Epithelial(13;5.36e-06)|all cancers(10;1.4e-05)|OV - Ovarian serous cystadenocarcinoma(96;0.00323)|COAD - Colon adenocarcinoma(1;0.00925)|Colorectal(20;0.0198)		AGTGATCCATGGGGTGGACGT	0.363		NA											7	33					1.77e-08	2.17e-08	1	0
GRM7	2917	broad.mit.edu	37	3	7494447	7494447	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:7494447C>T	uc003bqm.2	+	6	1602	c.1328C>T	c.(1327-1329)GCT>GTT	p.A443V	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Missense_Mutation_p.A443V|GRM7_uc003bql.2_Missense_Mutation_p.A443V|GRM7_uc003bqn.1_Missense_Mutation_p.A26V|GRM7_uc010hch.1_5'UTR	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	443	Extracellular (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	ATGGAGCAAGCTGGAGGCAAG	0.463		NA											3	11					0	0	0	0
PLCL2	23228	broad.mit.edu	37	3	17051331	17051331	+	Silent	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:17051331C>T	uc011awc.1	+	5	574	c.469C>T	c.(469-471)CTG>TTG	p.L157L	PLCL2_uc010het.1_Silent_p.L39L|PLCL2_uc011awd.1_Silent_p.L39L	NM_001144382	NP_001137854	Q9UPR0	PLCL2_HUMAN	phospholipase C-like 2 isoform 1	165	PH.				intracellular signal transduction|lipid metabolic process	cytoplasm	calcium ion binding|phosphatidylinositol phospholipase C activity|signal transducer activity			skin(2)|ovary(1)|lung(1)	4						GTACTTTTTACTGGATGCTGA	0.403		NA											4	30					0	0	0	0
STAC	6769	broad.mit.edu	37	3	36545898	36545898	+	Silent	SNP	A	A	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:36545898A>T	uc003cgh.1	+	7	819	c.780A>T	c.(778-780)CCA>CCT	p.P260P	STAC_uc010hgd.1_RNA|STAC_uc011aya.1_Silent_p.P199P	NM_003149	NP_003140	Q99469	STAC_HUMAN	SH3 and cysteine rich domain	260					intracellular signal transduction	cytoplasm|soluble fraction	metal ion binding			skin(2)|ovary(1)|pancreas(1)	4						TTACATATCCAGAAAATGGCA	0.373		NA											3	22					0	0	0	0
LTF	4057	broad.mit.edu	37	3	46479621	46479621	+	Splice_Site	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:46479621C>A	uc003cpq.2	-	16	1947	c.1909_splice	c.e16-1	p.A637_splice	LTF_uc003fzr.2_Splice_Site_p.A593_splice|LTF_uc010hjh.2_Splice_Site_p.A635_splice|LTF_uc003cpr.2_Splice_Site_p.A624_splice	NM_002343	NP_002334	P02788	TRFL_HUMAN	lactotransferrin precursor						cellular iron ion homeostasis|defense response to bacterium|humoral immune response|iron ion transport	extracellular region|stored secretory granule	ferric iron binding|heparin binding|protein binding|serine-type endopeptidase activity	p.?(1)		central_nervous_system(2)|ovary(1)|lung(1)	4				all cancers(1;7.55e-14)|GBM - Glioblastoma multiforme(1;2.1e-09)|Epithelial(1;9.25e-07)|Colorectal(1;3.81e-05)|BRCA - Breast invasive adenocarcinoma(193;0.00129)|COAD - Colon adenocarcinoma(1;0.00308)|KIRC - Kidney renal clear cell carcinoma(197;0.0205)|Kidney(197;0.0242)|OV - Ovarian serous cystadenocarcinoma(275;0.089)	Pefloxacin(DB00487)	CAAATTTAGCCTGCGACAAAA	0.448		NA											15	95					1.36e-06	1.61e-06	1	0
PFKFB4	5210	broad.mit.edu	37	3	48563099	48563099	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:48563099C>T	uc003ctv.2	-	10	1008	c.991G>A	c.(991-993)GTC>ATC	p.V331I	PFKFB4_uc003ctw.2_Missense_Mutation_p.V140I|PFKFB4_uc010hkc.2_Intron|PFKFB4_uc003ctx.2_Missense_Mutation_p.V288I|PFKFB4_uc010hkb.2_Missense_Mutation_p.V324I|PFKFB4_uc011bbm.1_Missense_Mutation_p.V320I|PFKFB4_uc011bbn.1_RNA	NM_004567	NP_004558	Q16877	F264_HUMAN	6-phosphofructo-2-kinase/fructose-2,	331	Fructose-2,6-bisphosphatase.				fructose 2,6-bisphosphate metabolic process|glycolysis	cytosol	6-phosphofructo-2-kinase activity|ATP binding|fructose-2,6-bisphosphate 2-phosphatase activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.0003)|KIRC - Kidney renal clear cell carcinoma(197;0.00596)|Kidney(197;0.00684)		TCCTCACAGACGCCCTAGGGA	0.542		NA											5	16					0	0	0	0
QARS	5859	broad.mit.edu	37	3	49142161	49142161	+	Silent	SNP	C	C	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:49142161C>G	uc003cvx.2	-	1	11	c.6G>C	c.(4-6)GCG>GCC	p.A2A	QARS_uc011bcd.1_5'Flank|QARS_uc003cvy.2_5'UTR|QARS_uc011bce.1_Silent_p.A2A|QARS_uc011bcf.1_Silent_p.A2A	NM_005051	NP_005042	P47897	SYQ_HUMAN	glutaminyl-tRNA synthetase	2					glutaminyl-tRNA aminoacylation	cytosol|mitochondrial matrix	ATP binding|glutamine-tRNA ligase activity|protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)	L-Glutamine(DB00130)	AGTCTAGAGCCGCCATTGCAG	0.612		NA											8	45					0	0	0	0
ERC2	26059	broad.mit.edu	37	3	56468959	56468959	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:56468959C>T	uc003dhr.1	-	2	333	c.77G>A	c.(76-78)CGT>CAT	p.R26H		NM_015576	NP_056391	O15083	ERC2_HUMAN	cytomatrix protein p110	26						cell junction|cytoplasm|cytoskeleton|growth cone|presynaptic membrane|synaptosome	protein binding			ovary(2)	2				KIRC - Kidney renal clear cell carcinoma(284;0.0667)|Kidney(284;0.0873)|OV - Ovarian serous cystadenocarcinoma(275;0.219)		GTGGCCCAAACGAGGAGACCT	0.488		NA											9	21					0	0	0	0
ZNF654	55279	broad.mit.edu	37	3	88189924	88189924	+	Missense_Mutation	SNP	A	A	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:88189924A>C	uc003dqv.2	+	1	1663	c.1464A>C	c.(1462-1464)GAA>GAC	p.E488D	CGGBP1_uc003dqu.2_Intron	NM_018293	NP_060763	Q8IZM8	ZN654_HUMAN	zinc finger protein 654	488					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		Lung NSC(201;0.0283)		UCEC - Uterine corpus endometrioid carcinoma (27;0.194)|LUSC - Lung squamous cell carcinoma(29;0.00353)|Lung(72;0.00661)		TGACAAGTGAACATACTTCAT	0.413		NA											10	66					0	0	0	0
OR5H15	403274	broad.mit.edu	37	3	97887715	97887715	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:97887715C>A	uc011bgu.1	+	1	172	c.172C>A	c.(172-174)CCA>ACA	p.P58T		NM_001005515	NP_001005515	A6NDH6	O5H15_HUMAN	olfactory receptor, family 5, subfamily H,	58	Helical; Name=2; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						CCTTCATATCCCAATGTACTT	0.413		NA											33	101					9.77e-20	1.37e-19	1	0
IMPG2	50939	broad.mit.edu	37	3	100963523	100963523	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:100963523G>C	uc003duq.1	-	13	1855	c.1652C>G	c.(1651-1653)TCT>TGT	p.S551C	IMPG2_uc011bhe.1_Missense_Mutation_p.S414C	NM_016247	NP_057331	Q9BZV3	IMPG2_HUMAN	interphotoreceptor matrix proteoglycan 2	551	Extracellular (Potential).				visual perception	integral to membrane|proteinaceous extracellular matrix	extracellular matrix structural constituent|heparin binding|hyaluronic acid binding|receptor activity			ovary(2)|haematopoietic_and_lymphoid_tissue(1)	3						GGACACATCAGAGTCTTCCAT	0.393		NA											23	76					0	0	0	0
PHLDB2	90102	broad.mit.edu	37	3	111632432	111632432	+	Silent	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:111632432C>T	uc010hqa.2	+	3	2013	c.1602C>T	c.(1600-1602)ACC>ACT	p.T534T	PHLDB2_uc003dyc.2_Silent_p.T561T|PHLDB2_uc003dyd.2_Silent_p.T534T|PHLDB2_uc003dyg.2_Silent_p.T534T|PHLDB2_uc003dyh.2_Silent_p.T534T|PHLDB2_uc003dyi.2_Silent_p.T120T|PHLDB2_uc003dyf.3_Silent_p.T534T	NM_001134438	NP_001127910	Q86SQ0	PHLB2_HUMAN	pleckstrin homology-like domain, family B,	534						cytoplasm|intermediate filament cytoskeleton|plasma membrane				ovary(4)|skin(2)	6						GCTTCTTTACCCCCAGGAGCA	0.562		NA											30	84					0	0	0	0
SLC9A10	285335	broad.mit.edu	37	3	111958692	111958692	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:111958692A>G	uc003dyu.2	-	12	1663	c.1441T>C	c.(1441-1443)TAC>CAC	p.Y481H	SLC9A10_uc011bhu.1_5'UTR|SLC9A10_uc010hqc.2_Missense_Mutation_p.Y433H	NM_183061	NP_898884	Q4G0N8	S9A10_HUMAN	sperm-specific sodium proton exchanger	481					cell differentiation|multicellular organismal development|sodium ion transport|spermatogenesis	cilium|flagellar membrane|integral to membrane	solute:hydrogen antiporter activity			ovary(3)|breast(2)	5						CTTACCATGTATGGGTTTTCA	0.308		NA											5	15					0	0	0	0
FBXO40	51725	broad.mit.edu	37	3	121342100	121342100	+	Silent	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:121342100C>A	uc003eeg.2	+	3	2034	c.1824C>A	c.(1822-1824)GCC>GCA	p.A608A		NM_016298	NP_057382	Q9UH90	FBX40_HUMAN	F-box protein 40	608	F-box.				muscle cell differentiation	centrosome|nucleus	ubiquitin-protein ligase activity|zinc ion binding			ovary(2)|lung(1)|breast(1)|central_nervous_system(1)	5				GBM - Glioblastoma multiforme(114;0.189)		ATATCTGTGCCACTTTGTTAC	0.507		NA											21	81					1.98e-07	2.39e-07	1	0
IQCB1	9657	broad.mit.edu	37	3	121500720	121500720	+	Missense_Mutation	SNP	G	G	A	rs138646990		TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:121500720G>A	uc010hre.1	-	13	1495	c.1280C>T	c.(1279-1281)GCG>GTG	p.A427V	IQCB1_uc003eek.2_Missense_Mutation_p.A294V|IQCB1_uc010hrf.1_RNA	NM_001023570	NP_001018864	Q15051	IQCB1_HUMAN	IQ motif containing B1 isoform a	427	IQ 4.				cilium assembly|maintenance of organ identity|photoreceptor cell maintenance	centrosome|photoreceptor connecting cilium	calmodulin binding				0				GBM - Glioblastoma multiforme(114;0.0983)		GAATTTAAGCGCCTGGAAGAA	0.388		NA											22	56					0	0	0	0
PLXNA1	5361	broad.mit.edu	37	3	126723963	126723963	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:126723963C>T	uc003ejg.2	+	6	1709	c.1705C>T	c.(1705-1707)CTC>TTC	p.L569F		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	592	Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		CGTGCCTGACCTCTCAGCTGG	0.657		NA											11	36					0	0	0	0
PLXNA1	5361	broad.mit.edu	37	3	126733570	126733570	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:126733570G>A	uc003ejg.2	+	13	2708	c.2704G>A	c.(2704-2706)GGG>AGG	p.G902R		NM_032242	NP_115618	Q9UIW2	PLXA1_HUMAN	plexin A1	925	IPT/TIG 1.|Extracellular (Potential).				axon guidance	integral to membrane|intracellular|plasma membrane	semaphorin receptor activity			ovary(1)|pancreas(1)|skin(1)	3				GBM - Glioblastoma multiforme(114;0.155)		CTGTGAGATCGGGGACGCCAG	0.577		NA											9	21					0	0	0	0
BFSP2	8419	broad.mit.edu	37	3	133119261	133119261	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:133119261G>T	uc003epn.1	+	1	472	c.334G>T	c.(334-336)GGG>TGG	p.G112W		NM_003571	NP_003562	Q13515	BFSP2_HUMAN	phakinin	112	Head.				response to stimulus|visual perception	cytoplasm|intermediate filament|membrane	structural constituent of cytoskeleton|structural constituent of eye lens				0						TGAGGACCTAGGGGGCTGCCT	0.607		NA											30	55					6.03e-27	8.66e-27	1	0
KY	339855	broad.mit.edu	37	3	134348510	134348510	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:134348510G>A	uc010hty.2	-	4	352	c.290C>T	c.(289-291)CCT>CTT	p.P97L	KY_uc011blw.1_Missense_Mutation_p.P97L|KY_uc011blx.1_Missense_Mutation_p.P76L|KY_uc003eqs.1_Missense_Mutation_p.P117L	NM_178554	NP_848649	Q8NBH2	KY_HUMAN	kyphoscoliosis peptidase	97						cytoskeleton|Z disc	peptidase activity			ovary(2)	2						GGCATCTCGAGGGTGGACTTC	0.507		NA											3	7					0	0	0	0
ATR	545	broad.mit.edu	37	3	142186867	142186867	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:142186867T>C	uc003eux.3	-	39	6718	c.6596A>G	c.(6595-6597)AAT>AGT	p.N2199S	ATR_uc003euy.1_Missense_Mutation_p.N85S	NM_001184	NP_001175	Q13535	ATR_HUMAN	ataxia telangiectasia and Rad3 related protein	2199					cell cycle|cellular response to gamma radiation|cellular response to UV|DNA damage checkpoint|DNA repair|DNA replication|multicellular organismal development|negative regulation of DNA replication|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|protein autophosphorylation|replicative senescence	PML body	ATP binding|DNA binding|MutLalpha complex binding|MutSalpha complex binding|protein serine/threonine kinase activity			lung(5)|skin(5)|breast(4)|ovary(3)|stomach(1)|central_nervous_system(1)|liver(1)	20						AATAGCTTTATTGAGGATTTC	0.333		NA						Other_conserved_DNA_damage_response_genes					20	61					0	0	0	0
MME	4311	broad.mit.edu	37	3	154866441	154866441	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:154866441G>C	uc010hvr.1	+	16	1811	c.1600G>C	c.(1600-1602)GAG>CAG	p.E534Q	MME_uc003fab.1_Missense_Mutation_p.E534Q|MME_uc003fac.1_Missense_Mutation_p.E534Q|MME_uc003fad.1_Missense_Mutation_p.E534Q|MME_uc003fae.1_Missense_Mutation_p.E534Q	NM_007289	NP_009220	P08473	NEP_HUMAN	membrane metallo-endopeptidase	534	Extracellular (Potential).				cell-cell signaling|proteolysis	integral to plasma membrane	metal ion binding|metalloendopeptidase activity|protein binding			ovary(2)|central_nervous_system(1)	3		all_neural(597;0.00391)|Myeloproliferative disorder(1037;0.0122)	LUSC - Lung squamous cell carcinoma(72;0.114)|Lung(72;0.135)		Candoxatril(DB00616)	GGACAAAGATGAGTGCGTATA	0.348		NA											12	25					0	0	0	0
SCHIP1	29970	broad.mit.edu	37	3	159605505	159605505	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:159605505G>C	uc003fcs.1	+	5	1071	c.1005G>C	c.(1003-1005)CAG>CAC	p.Q335H	SCHIP1_uc003fcq.1_Missense_Mutation_p.Q411H|SCHIP1_uc003fcr.1_Missense_Mutation_p.Q324H|SCHIP1_uc003fct.1_Missense_Mutation_p.Q322H|SCHIP1_uc010hvz.1_Missense_Mutation_p.Q295H|SCHIP1_uc003fcu.1_Missense_Mutation_p.Q92H|SCHIP1_uc003fcv.1_Missense_Mutation_p.Q108H	NM_014575	NP_055390	Q9P0W5	SCHI1_HUMAN	schwannomin interacting protein 1	335						cytoplasm	identical protein binding|protein binding			ovary(1)|central_nervous_system(1)	2			LUSC - Lung squamous cell carcinoma(72;0.00523)|Lung(72;0.00534)			AGAGCAAACAGAGTTCTTCCT	0.468		NA											55	167					0	0	0	0
NMD3	51068	broad.mit.edu	37	3	160964156	160964156	+	Silent	SNP	A	A	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:160964156A>G	uc003feb.1	+	12	1169	c.1050A>G	c.(1048-1050)ACA>ACG	p.T350T	NMD3_uc003fec.2_Silent_p.T350T|NMD3_uc003fed.1_Silent_p.T350T|NMD3_uc010hwh.2_Silent_p.T170T	NM_015938	NP_057022	Q96D46	NMD3_HUMAN	NMD3 homolog	350					protein transport	cytoplasm|nucleolus|nucleoplasm				ovary(1)	1			Lung(72;0.00111)|LUSC - Lung squamous cell carcinoma(72;0.00156)			TACAGAAGACATCTGAAATGA	0.358		NA											9	38					0	0	0	0
SLITRK3	22865	broad.mit.edu	37	3	164906463	164906463	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:164906463C>A	uc003fej.3	-	2	2600	c.2156G>T	c.(2155-2157)AGT>ATT	p.S719I	SLITRK3_uc003fek.2_Missense_Mutation_p.S719I	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	719	Poly-Gly.|Cytoplasmic (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						accacccccacttccgccacc	0.453		NA								HNSCC(40;0.11)			10	25					1.11e-13	1.48e-13	1	0
SLITRK3	22865	broad.mit.edu	37	3	164908115	164908115	+	Silent	SNP	T	T	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:164908115T>A	uc003fej.3	-	2	948	c.504A>T	c.(502-504)GCA>GCT	p.A168A	SLITRK3_uc003fek.2_Silent_p.A168A	NM_014926	NP_055741	O94933	SLIK3_HUMAN	slit and trk like 3 protein precursor	168	LRR 4.|Extracellular (Potential).					integral to membrane				ovary(6)|skin(3)|pancreas(1)	10						GGTTCCGAAATGCCCCACTCT	0.383		NA								HNSCC(40;0.11)			13	57					0	0	0	0
YEATS2	55689	broad.mit.edu	37	3	183479353	183479353	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:183479353A>T	uc003fly.2	+	14	1910	c.1715A>T	c.(1714-1716)AAG>ATG	p.K572M		NM_018023	NP_060493	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	572					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			ovary(3)|large_intestine(1)	4	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			AGTCACCCTAAGGTTCAAAGC	0.413		NA											34	118					0	0	0	0
FETUB	26998	broad.mit.edu	37	3	186358445	186358445	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:186358445C>G	uc010hyq.2	+	2	457	c.196C>G	c.(196-198)CGA>GGA	p.R66G	FETUB_uc011brz.1_Intron|FETUB_uc003fqn.2_Missense_Mutation_p.R66G|FETUB_uc003fqo.2_5'UTR|FETUB_uc010hyr.2_Missense_Mutation_p.R66G|FETUB_uc010hys.2_5'UTR|FETUB_uc003fqp.3_Missense_Mutation_p.R66G	NM_014375	NP_055190	Q9UGM5	FETUB_HUMAN	fetuin B precursor	66	Cystatin fetuin-B-type 1.					extracellular space	cysteine-type endopeptidase inhibitor activity			ovary(1)|lung(1)	2	all_cancers(143;6.64e-12)|Ovarian(172;0.0339)		OV - Ovarian serous cystadenocarcinoma(80;5.73e-20)	GBM - Glioblastoma multiforme(93;0.0479)		GAGACTCAACCGAGTGAACGA	0.572		NA											44	132					0	0	0	0
FGF12	2257	broad.mit.edu	37	3	192125893	192125893	+	Silent	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr3:192125893C>T	uc003fsx.2	-	1	946	c.120G>A	c.(118-120)CTG>CTA	p.L40L	FGF12_uc003fsy.2_Intron	NM_021032	NP_066360	P61328	FGF12_HUMAN	fibroblast growth factor 12 isoform 1	40					cell-cell signaling|heart development|JNK cascade|nervous system development|signal transduction	extracellular space|nucleus	growth factor activity|heparin binding			ovary(1)|skin(1)|lung(1)|pancreas(1)	4	all_cancers(143;1.72e-08)|Ovarian(172;0.0634)|Breast(254;0.247)	Lung NSC(153;0.21)	LUSC - Lung squamous cell carcinoma(58;5.45e-06)|Lung(62;6.17e-06)	GBM - Glioblastoma multiforme(46;0.00032)		GCCTCTCGCACAGGGAGCGCC	0.672		NA											33	134					0	0	0	0
ZNF718	255403	broad.mit.edu	37	4	59331	59331	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:59331A>T	uc003fzt.3	+	6	145	c.12A>T	c.(10-12)TTA>TTT	p.L4F	ZNF595_uc003fzu.1_RNA|ZNF595_uc010iay.1_RNA|ZNF595_uc003fzv.1_Silent_p.V4V|ZNF595_uc011bus.1_5'UTR|ZNF595_uc011but.1_Intron	NM_001039127	NP_001034216	Q3SXZ3	ZN718_HUMAN	zinc finger protein 718	4	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(4;0.0738)|all_epithelial(65;0.139)		Lung(54;0.0681)|Epithelial(2;0.0838)|all cancers(2;0.135)|LUSC - Lung squamous cell carcinoma(95;0.18)		AGGAACTCGTAACATTCAGGG	0.408		NA											21	426					0	0	0	0
WHSC1	7468	broad.mit.edu	37	4	1902706	1902706	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:1902706G>T	uc003gdz.3	+	2	501	c.325G>T	c.(325-327)GGG>TGG	p.G109W	WHSC1_uc003geb.3_Missense_Mutation_p.G109W|WHSC1_uc003gec.3_Missense_Mutation_p.G109W|WHSC1_uc003ged.3_Missense_Mutation_p.G109W|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gdx.2_Missense_Mutation_p.G109W|WHSC1_uc003gdy.1_Missense_Mutation_p.G109W|WHSC1_uc010icd.1_Missense_Mutation_p.G109W|WHSC1_uc003gea.1_Missense_Mutation_p.G109W|WHSC1_uc010ice.1_Missense_Mutation_p.G109W|WHSC1_uc003geg.1_Missense_Mutation_p.G109W|WHSC1_uc003geh.1_Missense_Mutation_p.G109W	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	109					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		GAAAGGGATTGGGACACCCCC	0.463		NA	T	IGH@	MM								25	67					4.23e-11	5.46e-11	1	0
WHSC1	7468	broad.mit.edu	37	4	1980436	1980436	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:1980436C>A	uc003gdz.3	+	22	4074	c.3898C>A	c.(3898-3900)CCC>ACC	p.P1300T	WHSC1_uc003geb.3_Missense_Mutation_p.P1300T|WHSC1_uc003gec.3_Missense_Mutation_p.P1300T|WHSC1_uc003ged.3_Missense_Mutation_p.P1300T|WHSC1_uc003gee.3_RNA|WHSC1_uc003gef.3_RNA|WHSC1_uc003gei.3_Missense_Mutation_p.P519T|WHSC1_uc011bvh.1_Missense_Mutation_p.P361T|WHSC1_uc010icf.2_Missense_Mutation_p.P648T	NM_001042424	NP_001035889	O96028	NSD2_HUMAN	Wolf-Hirschhorn syndrome candidate 1 protein	1300					anatomical structure morphogenesis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|cytoplasm|nuclear membrane|nucleolus	DNA binding|histone-lysine N-methyltransferase activity|zinc ion binding			ovary(3)|lung(3)|skin(2)|pancreas(1)	9		all_epithelial(65;1.34e-05)	OV - Ovarian serous cystadenocarcinoma(23;0.00606)	STAD - Stomach adenocarcinoma(129;0.232)		CCACCTCTGCCCCAATTCGTT	0.562		NA	T	IGH@	MM								27	38					1.34e-20	1.89e-20	1	0
HTT	3064	broad.mit.edu	37	4	3182271	3182271	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:3182271G>A	uc011bvq.1	+	37	4793	c.4648G>A	c.(4648-4650)GAC>AAC	p.D1550N		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	1548					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		CATAGTCCACGACCTCTTTGT	0.443		NA											25	76					0	0	0	0
WFS1	7466	broad.mit.edu	37	4	6302728	6302728	+	Silent	SNP	G	G	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:6302728G>C	uc003giy.2	+	8	1372	c.1206G>C	c.(1204-1206)CTG>CTC	p.L402L	WFS1_uc003gix.2_Silent_p.L402L|WFS1_uc003giz.2_Silent_p.L220L	NM_001145853	NP_001139325	O76024	WFS1_HUMAN	wolframin	402	Helical; (Potential).				endoplasmic reticulum calcium ion homeostasis|endoplasmic reticulum unfolded protein response|ER overload response|ER-associated protein catabolic process|glucose homeostasis|kidney development|negative regulation of neuron apoptosis|negative regulation of sequence-specific DNA binding transcription factor activity|polyubiquitinated misfolded protein transport|positive regulation of calcium ion transport|positive regulation of growth|positive regulation of protein ubiquitination|positive regulation of proteolysis|protein stabilization|renal water homeostasis|sensory perception of sound|visual perception	dendrite|integral to endoplasmic reticulum membrane	activating transcription factor binding|ATPase binding|transporter activity|ubiquitin protein ligase binding			central_nervous_system(2)	2				Colorectal(103;0.0512)		GGAACCACCTGGAGCCCTATG	0.607		NA											42	172					0	0	0	0
C4orf23	152992	broad.mit.edu	37	4	8477672	8477672	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:8477672C>T	uc003glg.1	+	11	1719	c.1531C>T	c.(1531-1533)CAT>TAT	p.H511Y	C4orf23_uc003glh.1_Missense_Mutation_p.H348Y|C4orf23_uc003gli.1_RNA	NM_152544	NP_689757	Q8IYL2	TRM44_HUMAN	hypothetical protein LOC152992 isoform 2	740					tRNA processing	cytoplasm	methyltransferase activity|nucleic acid binding|zinc ion binding				0						CCCGTTTGCCCATGGGCCTGC	0.622		NA											25	172					0	0	0	0
GABRA2	2555	broad.mit.edu	37	4	46252411	46252411	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:46252411C>G	uc003gxc.3	-	9	1943	c.1270G>C	c.(1270-1272)GTT>CTT	p.V424L	GABRA2_uc010igc.2_Missense_Mutation_p.V424L|GABRA2_uc011bzc.1_Missense_Mutation_p.V429L	NM_001114175	NP_001107647	P47869	GBRA2_HUMAN	gamma-aminobutyric acid A receptor, alpha 2	424	Helical; (Probable).				gamma-aminobutyric acid signaling pathway|neurotransmitter transport|regulation of neurotransmitter levels	cell junction|chloride channel complex|integral to synaptic vesicle membrane|postsynaptic membrane	benzodiazepine receptor activity|chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)|skin(2)	4					Alprazolam(DB00404)|Bromazepam(DB01558)|Diazepam(DB00829)|Ethchlorvynol(DB00189)|Fludiazepam(DB01567)|Flunitrazepam(DB01544)|Flurazepam(DB00690)|Lorazepam(DB00186)|Meprobamate(DB00371)|Midazolam(DB00683)	ACTGGAAAAACTATTCTGGAC	0.393		NA											32	84					0	0	0	0
PDGFRA	5156	broad.mit.edu	37	4	55161418	55161418	+	Silent	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:55161418G>T	uc003han.3	+	23	3580	c.3249G>T	c.(3247-3249)CTG>CTT	p.L1083L	PDGFRA_uc003haa.2_Silent_p.L843L	NM_006206	NP_006197	P16234	PGFRA_HUMAN	platelet-derived growth factor receptor alpha	1083	Ser-rich.|Cytoplasmic (Potential).				cardiac myofibril assembly|cell activation|luteinization|metanephric glomerular capillary formation|peptidyl-tyrosine phosphorylation|positive regulation of cell migration|positive regulation of DNA replication|positive regulation of fibroblast proliferation|protein autophosphorylation|retina vasculature development in camera-type eye	cytoplasm|integral to plasma membrane|nucleus	ATP binding|platelet-derived growth factor alpha-receptor activity|platelet-derived growth factor binding|platelet-derived growth factor receptor binding|protein homodimerization activity|vascular endothelial growth factor receptor activity			soft_tissue(572)|small_intestine(40)|stomach(16)|lung(16)|central_nervous_system(13)|haematopoietic_and_lymphoid_tissue(7)|skin(3)|ovary(3)|gastrointestinal_tract_(site_indeterminate)(1)|autonomic_ganglia(1)|prostate(1)|bone(1)	674	all_cancers(7;0.000425)|all_lung(4;0.000343)|Lung NSC(11;0.000467)|all_epithelial(27;0.0131)|all_neural(26;0.0209)|Glioma(25;0.08)		GBM - Glioblastoma multiforme(1;4.18e-71)|all cancers(1;4.76e-45)|LUSC - Lung squamous cell carcinoma(32;0.00256)		Becaplermin(DB00102)|Imatinib(DB00619)|Sunitinib(DB01268)	CTTCAGACCTGGTGGAAGACA	0.512		NA	Mis|O|T	FIP1L1	GIST|idiopathic hypereosinophilic syndrome				Gastrointestinal_Stromal_Tumors_Sporadic_Multiple_Primary|Familial_Intestinal_Neurofibromatosis	TSP Lung(21;0.16)			30	85					1.62e-16	2.22e-16	1	0
EXOC1	55763	broad.mit.edu	37	4	56763010	56763010	+	Missense_Mutation	SNP	G	G	T	rs142941850	by1000genomes	TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:56763010G>T	uc003hbe.1	+	16	2239	c.2081G>T	c.(2080-2082)CGT>CTT	p.R694L	EXOC1_uc003hbf.1_Missense_Mutation_p.R694L|EXOC1_uc003hbg.1_Missense_Mutation_p.R679L	NM_018261	NP_060731	Q9NV70	EXOC1_HUMAN	exocyst complex component 1 isoform 1	694					exocytosis|protein transport	exocyst	protein binding			ovary(2)|skin(2)|lung(1)|central_nervous_system(1)	6	Glioma(25;0.08)|all_neural(26;0.101)					AATGCTGAGCGTCGTGGAGAC	0.338		NA											12	36					2.27e-07	2.72e-07	1	0
YTHDC1	91746	broad.mit.edu	37	4	69184563	69184563	+	Nonsense_Mutation	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:69184563G>A	uc003hdx.2	-	13	2055	c.1702C>T	c.(1702-1704)CGA>TGA	p.R568*	YTHDC1_uc003hdy.2_Nonsense_Mutation_p.R550*	NM_001031732	NP_001026902	Q96MU7	YTDC1_HUMAN	splicing factor YT521-B isoform 1	568	Arg-rich.									upper_aerodigestive_tract(1)|ovary(1)	2						TCCTGGTATCGTGGATCCTTT	0.328		NA											9	77					0	0	0	0
UGT2B15	7366	broad.mit.edu	37	4	69519826	69519826	+	Silent	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:69519826G>A	uc011cal.1	-	5	1280	c.1242C>T	c.(1240-1242)CTC>CTT	p.L414L		NM_001076	NP_001067	P54855	UDB15_HUMAN	UDP glycosyltransferase 2B15 precursor	414					steroid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|integral to membrane|microsome	glucuronosyltransferase activity				0						TGTCCACACTGAGGGCTGCTC	0.468		NA											50	127					0	0	0	0
BTC	685	broad.mit.edu	37	4	75675872	75675872	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:75675872T>A	uc003hig.2	-	4	686	c.339A>T	c.(337-339)AGA>AGT	p.R113S		NM_001729	NP_001720	P35070	BTC_HUMAN	betacellulin precursor	113	Extracellular (Potential).				positive regulation of cell division|positive regulation of cell proliferation	extracellular space|integral to membrane|plasma membrane|soluble fraction	epidermal growth factor receptor binding|growth factor activity			central_nervous_system(1)|skin(1)	2			Lung(101;0.219)			CTCTGTCTCCTCTTAGGTAAA	0.398		NA											51	164					0	0	0	0
ART3	419	broad.mit.edu	37	4	77003168	77003168	+	Silent	SNP	T	T	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:77003168T>C	uc003hjo.2	+	3	380	c.261T>C	c.(259-261)CCT>CCC	p.P87P	ART3_uc003hji.2_Silent_p.P87P|ART3_uc003hjj.2_Silent_p.P87P|ART3_uc003hjk.2_Silent_p.P87P|ART3_uc010ija.1_Silent_p.P87P|ART3_uc003hjn.2_Silent_p.P87P|ART3_uc003hjp.2_Intron|ART3_uc010ijb.2_Intron|ART3_uc003hjq.2_Intron|ART3_uc003hjr.2_Silent_p.P57P|ART3_uc010ijc.2_Silent_p.P57P|ART3_uc010ijd.2_Silent_p.P57P	NM_001130016	NP_001123488	Q13508	NAR3_HUMAN	ADP-ribosyltransferase 3 isoform a	87					protein ADP-ribosylation	anchored to membrane|integral to plasma membrane	NAD(P)+-protein-arginine ADP-ribosyltransferase activity|NAD+ ADP-ribosyltransferase activity			ovary(2)	2			Lung(101;0.0809)|LUSC - Lung squamous cell carcinoma(112;0.0934)			TCTTTCTCCCTATGAATTTTA	0.423		NA											27	53					0	0	0	0
GK2	2712	broad.mit.edu	37	4	80327826	80327826	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:80327826G>A	uc003hlu.2	-	1	1547	c.1529C>T	c.(1528-1530)TCA>TTA	p.S510L		NM_033214	NP_149991	Q14410	GLPK2_HUMAN	glycerol kinase 2	510					glycerol-3-phosphate metabolic process	mitochondrial outer membrane	ATP binding|glycerol kinase activity			ovary(2)|skin(2)	4						CCAACCCATTGACTTCATTAC	0.443		NA											19	74					0	0	0	0
SLC39A8	64116	broad.mit.edu	37	4	103225478	103225478	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:103225478A>G	uc003hwb.1	-	5	1365	c.836T>C	c.(835-837)CTA>CCA	p.L279P	SLC39A8_uc011ceo.1_Missense_Mutation_p.L279P|SLC39A8_uc003hwa.1_Missense_Mutation_p.L212P|SLC39A8_uc003hwc.2_Missense_Mutation_p.L279P	NM_022154	NP_071437	Q9C0K1	S39A8_HUMAN	solute carrier family 39 (zinc transporter),	279	Extracellular (Potential).					integral to membrane|organelle membrane|plasma membrane	zinc ion transmembrane transporter activity				0		Hepatocellular(203;0.217)		all cancers(1;9.78e-10)|OV - Ovarian serous cystadenocarcinoma(123;1.52e-09)|GBM - Glioblastoma multiforme(1;0.000142)		ATATACCTGTAGAGATACCAC	0.348		NA											5	33					0	0	0	0
ANK2	287	broad.mit.edu	37	4	114179511	114179511	+	Silent	SNP	T	T	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:114179511T>C	uc003ibe.3	+	13	1430	c.1330T>C	c.(1330-1332)TTG>CTG	p.L444L	ANK2_uc003ibd.3_Silent_p.L423L|ANK2_uc003ibf.3_Silent_p.L444L|ANK2_uc003ibc.2_Silent_p.L420L|ANK2_uc011cgb.1_Silent_p.L459L	NM_001148	NP_001139	Q01484	ANK2_HUMAN	ankyrin 2 isoform 1	444	ANK 13.				axon guidance|signal transduction	apical plasma membrane|basolateral plasma membrane|cytoskeleton|cytosol|sarcomere	protein binding|protein binding			central_nervous_system(7)|ovary(3)|large_intestine(2)|breast(1)|skin(1)	14		Ovarian(17;0.0448)|Hepatocellular(203;0.218)		OV - Ovarian serous cystadenocarcinoma(123;4.92e-05)		CATGGGCCACTTGAACATTGT	0.532		NA											15	86					0	0	0	0
NUDT6	11162	broad.mit.edu	37	4	123814172	123814172	+	Silent	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:123814172C>A	uc003iew.2	-	5	794	c.762G>T	c.(760-762)CTG>CTT	p.L254L	FGF2_uc003iev.1_3'UTR|NUDT6_uc003iex.2_Silent_p.L85L	NM_007083	NP_009014	P53370	NUDT6_HUMAN	nudix-type motif 6 isoform a	254	Nudix hydrolase.					mitochondrion|nucleus	growth factor activity|hydrolase activity				0						CAGTCTTCGCCAGGTCATTGA	0.438		NA											31	95					1.08e-15	1.47e-15	1	0
ANKRD50	57182	broad.mit.edu	37	4	125593009	125593009	+	Missense_Mutation	SNP	T	T	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:125593009T>G	uc003ifg.3	-	3	1689	c.1423A>C	c.(1423-1425)ATG>CTG	p.M475L	ANKRD50_uc011cgo.1_Missense_Mutation_p.M296L|ANKRD50_uc010inw.2_Missense_Mutation_p.M475L	NM_020337	NP_065070	Q9ULJ7	ANR50_HUMAN	ankyrin repeat domain 50	475										central_nervous_system(1)	1						TTCCATATCATCCACAGAGCT	0.413		NA											19	63					0	0	0	0
PCDH10	57575	broad.mit.edu	37	4	134072306	134072306	+	Silent	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:134072306C>A	uc003iha.2	+	1	1837	c.1011C>A	c.(1009-1011)GCC>GCA	p.A337A	uc003igy.2_5'Flank|PCDH10_uc003igz.2_Silent_p.A337A	NM_032961	NP_116586	Q9P2E7	PCD10_HUMAN	protocadherin 10 isoform 1 precursor	337	Cadherin 3.|Extracellular (Potential).				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2				LUSC - Lung squamous cell carcinoma(193;0.227)		GCCCCAACGCCGTGCCTGCGC	0.607		NA											26	75					2.8e-10	3.55e-10	1	0
MAB21L2	10586	broad.mit.edu	37	4	151504976	151504976	+	Silent	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:151504976C>A	uc003ilw.2	+	1	1900	c.795C>A	c.(793-795)CCC>CCA	p.P265P	LRBA_uc003ils.3_5'Flank|LRBA_uc003ilt.3_Intron|LRBA_uc003ilu.3_Intron|LRBA_uc010ipj.2_Intron	NM_006439	NP_006430	Q9Y586	MB212_HUMAN	mab-21-like protein 2	265					nervous system development	nucleus		p.P265T(1)		ovary(1)	1	all_hematologic(180;0.151)			GBM - Glioblastoma multiforme(119;0.159)		TGGAGCTACCCGGCCAGCCGC	0.627		NA											23	38					2.89e-11	3.74e-11	1	0
FGA	2243	broad.mit.edu	37	4	155507623	155507623	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:155507623T>C	uc003iod.1	-	5	1016	c.958A>G	c.(958-960)ACC>GCC	p.T320A	FGA_uc003ioe.1_Missense_Mutation_p.T320A|FGA_uc003iof.1_Intron	NM_000508	NP_000499	P02671	FIBA_HUMAN	fibrinogen, alpha polypeptide isoform alpha-E	320	By similarity.				platelet activation|platelet degranulation|protein polymerization|response to calcium ion|signal transduction	external side of plasma membrane|fibrinogen complex|platelet alpha granule lumen	eukaryotic cell surface binding|protein binding, bridging|receptor binding			ovary(2)|breast(1)	3	all_hematologic(180;0.215)	Renal(120;0.0458)			Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Sucralfate(DB00364)|Tenecteplase(DB00031)	GGTTTCCAGGTTGCAGTCCCT	0.572		NA											46	123					0	0	0	0
GUCY1A3	2982	broad.mit.edu	37	4	156632130	156632130	+	Silent	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:156632130C>A	uc003iov.2	+	7	1349	c.813C>A	c.(811-813)CCC>CCA	p.P271P	GUCY1A3_uc003iou.2_Silent_p.P271P|GUCY1A3_uc010iqc.2_Silent_p.P271P|GUCY1A3_uc003iow.2_Silent_p.P271P|GUCY1A3_uc010iqd.2_Silent_p.P270P|GUCY1A3_uc003iox.2_Silent_p.P271P|GUCY1A3_uc003ioz.2_Silent_p.P36P|GUCY1A3_uc003ioy.2_Silent_p.P271P|GUCY1A3_uc010iqe.2_Silent_p.P36P|GUCY1A3_uc003ipa.2_Intron|GUCY1A3_uc003ipb.2_Silent_p.P271P	NM_000856	NP_000847	Q02108	GCYA3_HUMAN	guanylate cyclase 1, soluble, alpha 3 isoform A	271					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble	GTP binding|guanylate cyclase activity|heme binding|receptor activity			central_nervous_system(2)|ovary(1)|skin(1)	4	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.17)		CCAGCAAACCCCAGTCCTCGC	0.463		NA											17	48					0.00152264	0.00163351	1	0
FSTL5	56884	broad.mit.edu	37	4	162841715	162841715	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:162841715G>T	uc003iqh.2	-	4	686	c.250C>A	c.(250-252)CAA>AAA	p.Q84K	FSTL5_uc003iqi.2_Missense_Mutation_p.Q83K|FSTL5_uc010iqv.2_Missense_Mutation_p.Q83K	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	84	Kazal-like.					extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		CATTCTGCTTGCCCTGTCTCT	0.443		NA											10	21					2.18e-05	2.49e-05	1	0
NPY1R	4886	broad.mit.edu	37	4	164247554	164247554	+	Silent	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:164247554G>T	uc003iqm.1	-	2	419	c.153C>A	c.(151-153)ATC>ATA	p.I51I	NPY1R_uc011cjj.1_Intron	NM_000909	NP_000900	P25929	NPY1R_HUMAN	neuropeptide Y receptor Y1	51	Helical; Name=1; (Potential).				inhibition of adenylate cyclase activity by G-protein signaling pathway|outflow tract morphogenesis	integral to plasma membrane	protein binding			lung(1)|pancreas(1)	2	all_hematologic(180;0.166)	Prostate(90;0.0959)|all_neural(102;0.223)				CACCAAGAATGATCACAGCTC	0.413		NA											28	64					1.89e-17	2.61e-17	1	0
TLL1	7092	broad.mit.edu	37	4	166910564	166910564	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:166910564T>A	uc003irh.1	+	2	848	c.201T>A	c.(199-201)GAT>GAA	p.D67E	TLL1_uc011cjn.1_Missense_Mutation_p.D67E|TLL1_uc011cjo.1_5'UTR	NM_012464	NP_036596	O43897	TLL1_HUMAN	tolloid-like 1 precursor	67					cell differentiation|proteolysis|skeletal system development	extracellular region	calcium ion binding|metalloendopeptidase activity|zinc ion binding			skin(3)|ovary(2)|breast(1)|central_nervous_system(1)	7	all_hematologic(180;0.221)	Melanoma(52;0.0315)|Prostate(90;0.0405)		GBM - Glioblastoma multiforme(119;0.103)		CCTTAGATGATGAAGACTTAA	0.333		NA											21	47					0	0	0	0
SPOCK3	50859	broad.mit.edu	37	4	167663155	167663155	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:167663155C>A	uc003iri.1	-	10	1137	c.996G>T	c.(994-996)AAG>AAT	p.K332N	SPOCK3_uc011cjp.1_Missense_Mutation_p.K289N|SPOCK3_uc011cjq.1_Missense_Mutation_p.K341N|SPOCK3_uc011cjr.1_Missense_Mutation_p.K212N|SPOCK3_uc003irj.1_Missense_Mutation_p.K329N|SPOCK3_uc011cjs.1_Missense_Mutation_p.K281N|SPOCK3_uc011cjt.1_Missense_Mutation_p.K240N|SPOCK3_uc011cju.1_Missense_Mutation_p.K225N|SPOCK3_uc011cjv.1_Missense_Mutation_p.K234N	NM_016950	NP_058646	Q9BQ16	TICN3_HUMAN	testican 3 isoform 2	332	Thyroglobulin type-1.				signal transduction	proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase inhibitor activity			large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_hematologic(180;0.221)	Prostate(90;0.0181)|Renal(120;0.0184)|Melanoma(52;0.0198)		GBM - Glioblastoma multiforme(119;0.02)		CACCTAGGAGCTTCTTTACCC	0.378		NA											18	43					1.98e-07	2.39e-07	1	0
ODZ3	55714	broad.mit.edu	37	4	183600970	183600970	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:183600970T>C	uc003ivd.1	+	7	1515	c.1478T>C	c.(1477-1479)CTG>CCG	p.L493P	ODZ3_uc003ive.1_5'Flank	NM_001080477	NP_001073946	Q9P273	TEN3_HUMAN	odz, odd Oz/ten-m homolog 3	493	Extracellular (Potential).				signal transduction	integral to membrane					0		all_lung(41;2.69e-14)|Lung NSC(41;1.92e-11)|Melanoma(52;1.74e-05)|Colorectal(36;0.0062)|Breast(14;0.00748)|all_hematologic(60;0.0162)|Renal(120;0.0246)|Hepatocellular(41;0.0268)|Prostate(90;0.0283)|all_neural(102;0.155)|Medulloblastoma(177;0.184)		all cancers(43;1.42e-24)|Epithelial(43;6.86e-23)|OV - Ovarian serous cystadenocarcinoma(60;2.16e-11)|Colorectal(24;9.75e-06)|STAD - Stomach adenocarcinoma(60;2.96e-05)|COAD - Colon adenocarcinoma(29;0.00103)|GBM - Glioblastoma multiforme(59;0.00462)|LUSC - Lung squamous cell carcinoma(40;0.0391)|READ - Rectum adenocarcinoma(43;0.0487)		ATCTGGCATCTGGCTTTTTAT	0.483		NA											11	19					0	0	0	0
PDLIM3	27295	broad.mit.edu	37	4	186446225	186446225	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:186446225G>A	uc003ixw.3	-	2	318	c.194C>T	c.(193-195)GCG>GTG	p.A65V	PDLIM3_uc003ixx.3_Missense_Mutation_p.A65V|PDLIM3_uc010isi.2_RNA|PDLIM3_uc003ixy.2_Missense_Mutation_p.A65V|PDLIM3_uc003ixz.2_Missense_Mutation_p.A65V	NM_014476	NP_055291	Q53GG5	PDLI3_HUMAN	PDZ and LIM domain protein 3 isoform a	65	PDZ.					sarcomere	zinc ion binding			ovary(2)	2		all_lung(41;1.03e-13)|Lung NSC(41;2.49e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00826)|Renal(120;0.00988)|Prostate(90;0.00996)|Colorectal(36;0.0161)|all_hematologic(60;0.0592)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.4e-10)|BRCA - Breast invasive adenocarcinoma(30;8.64e-05)|GBM - Glioblastoma multiforme(59;0.000167)|STAD - Stomach adenocarcinoma(60;0.000828)|LUSC - Lung squamous cell carcinoma(40;0.00984)|COAD - Colon adenocarcinoma(29;0.0115)|READ - Rectum adenocarcinoma(43;0.171)		CCTGTCCTGCGCATCAGCATG	0.493		NA											29	90					0	0	0	0
KLKB1	3818	broad.mit.edu	37	4	187155174	187155174	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:187155174C>A	uc003iyy.2	+	4	361	c.290C>A	c.(289-291)TCT>TAT	p.S97Y	KLKB1_uc011clc.1_Translation_Start_Site|KLKB1_uc011cld.1_Missense_Mutation_p.S59Y	NM_000892	NP_000883	P03952	KLKB1_HUMAN	plasma kallikrein B1 precursor	97	Apple 1.				blood coagulation, intrinsic pathway|Factor XII activation|fibrinolysis|plasminogen activation|positive regulation of fibrinolysis	cytoplasm|extracellular space|plasma membrane	serine-type endopeptidase activity			ovary(1)	1		all_cancers(14;1.55e-52)|all_epithelial(14;7.69e-39)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Colorectal(36;0.00664)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|all_neural(102;0.243)		OV - Ovarian serous cystadenocarcinoma(60;1.29e-10)|BRCA - Breast invasive adenocarcinoma(30;3.8e-05)|GBM - Glioblastoma multiforme(59;0.000131)|STAD - Stomach adenocarcinoma(60;0.000292)|LUSC - Lung squamous cell carcinoma(40;0.00241)|READ - Rectum adenocarcinoma(43;0.168)		GGTGCAGTTTCTGGACATTCC	0.368		NA											32	84					5.83e-16	7.96e-16	1	0
CTNND2	1501	broad.mit.edu	37	5	11082943	11082943	+	Nonsense_Mutation	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr5:11082943G>A	uc003jfa.1	-	16	2798	c.2653C>T	c.(2653-2655)CGA>TGA	p.R885*	CTNND2_uc010itt.2_Nonsense_Mutation_p.R794*|CTNND2_uc011cmy.1_Nonsense_Mutation_p.R548*|CTNND2_uc011cmz.1_Nonsense_Mutation_p.R452*|CTNND2_uc010itu.1_RNA|CTNND2_uc011cmx.1_Nonsense_Mutation_p.R477*	NM_001332	NP_001323	Q9UQB3	CTND2_HUMAN	catenin (cadherin-associated protein), delta 2	885	ARM 8.				multicellular organismal development|neuron cell-cell adhesion|regulation of transcription, DNA-dependent|signal transduction|transcription, DNA-dependent	adherens junction|cytoplasm|nucleus	protein binding			large_intestine(2)|ovary(2)|skin(2)|pancreas(1)|lung(1)	8						ACAGCGGCTCGGATATATACT	0.547		NA											16	36					0	0	0	0
CDH12	1010	broad.mit.edu	37	5	21752113	21752113	+	Silent	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr5:21752113G>T	uc010iuc.2	-	12	2576	c.2118C>A	c.(2116-2118)CCC>CCA	p.P706P	CDH12_uc011cno.1_Silent_p.P666P|CDH12_uc003jgk.2_Silent_p.P706P|uc003jgj.2_Intron	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	706	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						TATCTTCCATGGGTGGTCTCT	0.453		NA								HNSCC(59;0.17)			14	58					6.72e-11	8.64e-11	1	0
CDH12	1010	broad.mit.edu	37	5	21752115	21752115	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr5:21752115G>T	uc010iuc.2	-	12	2574	c.2116C>A	c.(2116-2118)CCC>ACC	p.P706T	CDH12_uc011cno.1_Missense_Mutation_p.P666T|CDH12_uc003jgk.2_Missense_Mutation_p.P706T|uc003jgj.2_Intron	NM_004061	NP_004052	P55289	CAD12_HUMAN	cadherin 12, type 2 preproprotein	706	Cytoplasmic (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(2)	2						TCTTCCATGGGTGGTCTCTGA	0.448		NA								HNSCC(59;0.17)			14	57					6.72e-11	8.64e-11	1	0
CDH9	1007	broad.mit.edu	37	5	26903772	26903772	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr5:26903772G>T	uc003jgs.1	-	6	1142	c.973C>A	c.(973-975)CAG>AAG	p.Q325K	CDH9_uc010iug.2_Missense_Mutation_p.Q325K	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	325	Cadherin 3.|Extracellular (Potential).				adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						ATCCCTTCCTGTGTATCCTTG	0.398		NA											44	112					4.86e-25	6.95e-25	1	0
CDH9	1007	broad.mit.edu	37	5	26988327	26988327	+	Silent	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr5:26988327C>A	uc003jgs.1	-	2	283	c.114G>T	c.(112-114)GCG>GCT	p.A38A	CDH9_uc010iug.2_Silent_p.A38A	NM_016279	NP_057363	Q9ULB4	CADH9_HUMAN	cadherin 9, type 2 preproprotein	38					adherens junction organization|cell junction assembly|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(5)|skin(2)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)	9						TTGTCAGACCCGCTATCTTTT	0.393		NA											8	31					0.00307968	0.003284	1	0
PDZD2	23037	broad.mit.edu	37	5	31799682	31799682	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr5:31799682C>A	uc003jhl.2	+	2	715	c.327C>A	c.(325-327)CAC>CAA	p.H109Q	PDZD2_uc003jhm.2_Missense_Mutation_p.H109Q	NM_178140	NP_835260	O15018	PDZD2_HUMAN	PDZ domain containing 2	109	PDZ 1.				cell adhesion	cell-cell junction|endoplasmic reticulum|extracellular region|nucleus				central_nervous_system(4)|ovary(2)|skin(2)|large_intestine(1)	9						GGAAAACCCACCAGGGTCCTG	0.587		NA											26	87					1.55e-16	2.13e-16	1	0
UGT3A1	133688	broad.mit.edu	37	5	35965518	35965518	+	Silent	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr5:35965518C>T	uc003jjv.1	-	4	970	c.813G>A	c.(811-813)TTG>TTA	p.L271L	UGT3A1_uc003jjw.1_RNA|UGT3A1_uc011coq.1_Silent_p.L271L|UGT3A1_uc011cor.1_Silent_p.L237L|UGT3A1_uc003jjy.1_Silent_p.L217L	NM_152404	NP_689617	Q6NUS8	UD3A1_HUMAN	UDP glycosyltransferase 3 family, polypeptide A1	271	Extracellular (Potential).					integral to membrane	glucuronosyltransferase activity			ovary(2)|central_nervous_system(1)	3	all_lung(31;0.000197)		Epithelial(62;0.107)|Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GTTTTTCCATCAAGCCTCCAA	0.448		NA											23	54					0	0	0	0
SKIV2L2	23517	broad.mit.edu	37	5	54683820	54683820	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr5:54683820G>A	uc003jpy.3	+	19	2337	c.2071G>A	c.(2071-2073)GAT>AAT	p.D691N	SKIV2L2_uc011cqi.1_Missense_Mutation_p.D590N	NM_015360	NP_056175	P42285	SK2L2_HUMAN	superkiller viralicidic activity 2-like 2	691					maturation of 5.8S rRNA	catalytic step 2 spliceosome|nucleolus	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(1)|skin(1)	2		Lung NSC(810;0.000744)|Breast(144;0.181)|Prostate(74;0.194)				TGGTGAACTGGATCCTTTGTA	0.373		NA											12	29					0	0	0	0
ACTBL2	345651	broad.mit.edu	37	5	56777903	56777903	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr5:56777903C>T	uc003jrm.2	-	1	734	c.632G>A	c.(631-633)CGA>CAA	p.R211Q		NM_001017992	NP_001017992	Q562R1	ACTBL_HUMAN	actin, beta-like 2	211						cytoplasm|cytoskeleton	ATP binding			ovary(3)	3		Lung NSC(810;0.000135)|Prostate(74;0.055)|Breast(144;0.0707)|Ovarian(174;0.182)		OV - Ovarian serous cystadenocarcinoma(10;4.24e-37)		TTTGACATCTCGCACAATCTC	0.552		NA											23	50					0	0	0	0
YTHDC2	64848	broad.mit.edu	37	5	112920103	112920103	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr5:112920103C>T	uc003kqn.2	+	26	3935	c.3752C>T	c.(3751-3753)TCT>TTT	p.S1251F		NM_022828	NP_073739	Q9H6S0	YTDC2_HUMAN	YTH domain containing 2	1251	Ser-rich.						ATP binding|ATP-dependent helicase activity|nucleic acid binding			skin(2)|central_nervous_system(1)	3		all_cancers(142;7.69e-05)|all_epithelial(76;6.42e-07)|Colorectal(10;0.00278)|Prostate(80;0.00955)|Ovarian(225;0.0444)|Lung NSC(810;0.143)|all_lung(232;0.163)|Breast(839;0.244)		OV - Ovarian serous cystadenocarcinoma(64;7.2e-08)|Epithelial(69;8.83e-08)|all cancers(49;6.9e-06)|COAD - Colon adenocarcinoma(37;0.0458)|Colorectal(14;0.0594)		TCAGATCAGTCTTCTCTGAAA	0.428		NA											28	46					0	0	0	0
DMXL1	1657	broad.mit.edu	37	5	118505977	118505977	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr5:118505977T>A	uc003ksd.2	+	24	5672	c.5491T>A	c.(5491-5493)TCT>ACT	p.S1831T	DMXL1_uc010jcl.1_Missense_Mutation_p.S1831T	NM_005509	NP_005500	Q9Y485	DMXL1_HUMAN	Dmx-like 1	1831										ovary(2)	2		all_cancers(142;0.0314)|all_epithelial(76;0.00559)|Prostate(80;0.11)|Breast(839;0.231)		OV - Ovarian serous cystadenocarcinoma(64;0.000563)|Epithelial(69;0.00179)|all cancers(49;0.0243)		TTTTGGATCATCTGATACATT	0.353		NA											3	32					0	0	0	0
FBN2	2201	broad.mit.edu	37	5	127730926	127730926	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr5:127730926G>C	uc003kuu.2	-	9	1559	c.1120C>G	c.(1120-1122)CGC>GGC	p.R374G	FBN2_uc003kuv.2_Missense_Mutation_p.R341G	NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	374	TB 2.				bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TGTGCACAGCGGCCATTCACC	0.517		NA											8	14					0	0	0	0
SPOCK1	6695	broad.mit.edu	37	5	136476329	136476329	+	Missense_Mutation	SNP	A	A	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr5:136476329A>C	uc003lbo.2	-	3	478	c.287T>G	c.(286-288)GTG>GGG	p.V96G	SPOCK1_uc003lbp.2_Missense_Mutation_p.V96G	NM_004598	NP_004589	Q08629	TICN1_HUMAN	sparc/osteonectin, cwcv and kazal-like domains	96					cell adhesion|cell proliferation|cellular component movement|nervous system development|signal transduction	proteinaceous extracellular matrix	calcium ion binding			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			GGTCACACACACTTTGTGAGG	0.612		NA											5	12					0	0	0	0
CDHR2	54825	broad.mit.edu	37	5	176004720	176004720	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr5:176004720C>A	uc003mem.1	+	14	1499	c.1433C>A	c.(1432-1434)CCC>CAC	p.P478H	CDHR2_uc003men.1_Missense_Mutation_p.P478H	NM_017675	NP_060145	Q9BYE9	CDHR2_HUMAN	protocadherin LKC precursor	478	Extracellular (Potential).|Cadherin 4.				homophilic cell adhesion|negative regulation of cell growth	apical plasma membrane|cell junction|integral to membrane	calcium ion binding|protein binding			ovary(2)	2						GACCACAGGCCCACGTTTCCC	0.602		NA											16	21					1.15e-07	1.39e-07	1	0
TPMT	7172	broad.mit.edu	37	6	18148147	18148147	+	Splice_Site	SNP	C	C	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:18148147C>G	uc003ncm.2	-	3	296	c.141_splice	c.e3-1	p.Q47_splice	TPMT_uc010jpm.1_Splice_Site_p.Q47_splice	NM_000367	NP_000358	P51580	TPMT_HUMAN	thiopurine S-methyltransferase						xenobiotic metabolic process	cytosol	thiopurine S-methyltransferase activity				0	Ovarian(93;0.016)|Breast(50;0.0245)	all_hematologic(90;0.146)	all cancers(50;0.06)|Epithelial(50;0.0654)		Mercaptopurine(DB01033)	CTTTAATAGCCTGAAGAGGAA	0.274		NA											29	69					0	0	0	0
HDGFL1	154150	broad.mit.edu	37	6	22570038	22570038	+	Silent	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:22570038G>T	uc003nds.2	+	1	361	c.234G>T	c.(232-234)GGG>GGT	p.G78G		NM_138574	NP_612641	Q5TGJ6	HDGL1_HUMAN	hepatoma derived growth factor-like 1	78											0	Ovarian(93;0.163)					TCAGCGCGGGGCTGTGGGAAA	0.652		NA											10	14					2.18e-05	2.49e-05	1	0
HIST1H1T	3010	broad.mit.edu	37	6	26107876	26107876	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:26107876G>T	uc003ngj.2	-	1	489	c.446C>A	c.(445-447)ACC>AAC	p.T149N		NM_005323	NP_005314	P22492	H1T_HUMAN	histone cluster 1, H1t	149					cell differentiation|multicellular organismal development|nucleosome assembly|spermatogenesis	nucleosome	DNA binding			ovary(2)	2						TCTCTTATTGGTTTTAGCAGT	0.468		NA											34	85					4.32e-19	6.04e-19	1	0
BTN3A3	10384	broad.mit.edu	37	6	26452000	26452000	+	Silent	SNP	A	A	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:26452000A>T	uc003nhz.2	+	11	1296	c.1116A>T	c.(1114-1116)CCA>CCT	p.P372P	BTN3A3_uc003nia.2_Silent_p.P330P|BTN3A3_uc011dkn.1_Silent_p.P323P	NM_006994	NP_008925	O00478	BT3A3_HUMAN	butyrophilin, subfamily 3, member A3 isoform a	372	B30.2/SPRY.|Cytoplasmic (Potential).					integral to membrane					0						GGGATCTGCCAGACAACCCTG	0.537		NA											11	50					0	0	0	0
OR2B3	442184	broad.mit.edu	37	6	29054757	29054757	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:29054757T>C	uc003nlx.2	-	1	334	c.269A>G	c.(268-270)AAG>AGG	p.K90R		NM_001005226	NP_001005226			olfactory receptor, family 2, subfamily B,											skin(1)	1						GCTGATGGTCTTTTTGTTGCA	0.443		NA											20	73					0	0	0	0
OR12D2	26529	broad.mit.edu	37	6	29364491	29364491	+	Silent	SNP	C	C	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:29364491C>G	uc003nmf.3	+	1	76	c.15C>G	c.(13-15)ACC>ACG	p.T5T		NM_013936	NP_039224	P58182	O12D2_HUMAN	olfactory receptor, family 12, subfamily D,	5	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						TGAATACAACCTCAGTCACCG	0.428		NA											39	129					0	0	0	0
LTA	4049	broad.mit.edu	37	6	31540554	31540554	+	Missense_Mutation	SNP	T	T	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:31540554T>G	uc011dnu.1	+	2	248	c.35T>G	c.(34-36)GTG>GGG	p.V12G	LTA_uc003nue.1_Missense_Mutation_p.V12G|LTA_uc003nuf.2_5'Flank|LTA_uc003nuh.2_5'Flank|LTA_uc003nug.2_5'Flank|LTA_uc010jsr.2_5'Flank|TNF_uc003nui.2_5'Flank	NM_001159740	NP_001153212	P01374	TNFB_HUMAN	lymphotoxin alpha precursor	12					cell-cell signaling|induction of apoptosis|signal transduction	extracellular space|membrane	cytokine activity|tumor necrosis factor receptor binding				0					Etanercept(DB00005)	CTCCCAAGGGTGTGTGGCACC	0.592		NA											35	101					0	0	0	0
MOCS1	4337	broad.mit.edu	37	6	39874378	39874378	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:39874378G>A	uc003opb.2	-	10	1804	c.1666C>T	c.(1666-1668)CAC>TAC	p.H556Y	MOCS1_uc003opa.2_3'UTR|MOCS1_uc003opc.2_Missense_Mutation_p.H540Y|MOCS1_uc003opd.2_3'UTR|MOCS1_uc003ope.2_Missense_Mutation_p.H453Y	NM_005942	NP_005933	Q9NZB8	MOCS1_HUMAN	molybdenum cofactor synthesis-step 1 protein	556	Molybdenum cofactor biosynthesis protein C.				Mo-molybdopterin cofactor biosynthetic process|Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cytosol|molybdopterin synthase complex|nucleus	4 iron, 4 sulfur cluster binding|4 iron, 4 sulfur cluster binding|catalytic activity|GTP binding|metal ion binding			ovary(1)|liver(1)|central_nervous_system(1)	3	Ovarian(28;0.0355)|Colorectal(47;0.196)					AGGGCCACGTGGTGGCACAGA	0.652		NA											21	79					0	0	0	0
NCR2	9436	broad.mit.edu	37	6	41303865	41303865	+	Silent	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:41303865G>A	uc003oqh.2	+	2	180	c.93G>A	c.(91-93)GTG>GTA	p.V31V	NCR2_uc003oqi.2_Silent_p.V31V|NCR2_uc003oqj.2_Silent_p.V31V	NM_004828	NP_004819	O95944	NCTR2_HUMAN	natural cytotoxicity triggering receptor 2	31	Extracellular (Potential).|Ig-like.				cellular defense response	integral to plasma membrane	transmembrane receptor activity			ovary(1)	1	Ovarian(28;0.0327)|Colorectal(47;0.196)					TTCAAAGTGTGGCAGGGCAGA	0.557		NA											21	54					0	0	0	0
RHAG	6005	broad.mit.edu	37	6	49580244	49580244	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:49580244G>T	uc003ozk.3	-	6	873	c.811C>A	c.(811-813)CAC>AAC	p.H271N	RHAG_uc010jzl.2_Missense_Mutation_p.H271N|RHAG_uc010jzm.2_Missense_Mutation_p.H271N	NM_000324	NP_000315	Q02094	RHAG_HUMAN	Rh-associated glycoprotein	271	Helical; (Potential).				carbon dioxide transport|cellular ion homeostasis	integral to plasma membrane	ammonia transmembrane transporter activity|ammonium transmembrane transporter activity|ankyrin binding			breast(1)|skin(1)	2	Lung NSC(77;0.0255)					TTCTGAATGTGAACCTGTGTG	0.473		NA											12	28					2.27e-07	2.72e-07	1	0
PKHD1	5314	broad.mit.edu	37	6	51768526	51768526	+	Splice_Site	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:51768526C>T	uc003pah.1	-	43	7142	c.6866_splice	c.e43-1	p.D2289_splice	PKHD1_uc010jzn.1_Splice_Site_p.D272_splice|PKHD1_uc003pai.2_Splice_Site_p.D2289_splice	NM_138694	NP_619639	P08F94	PKHD1_HUMAN	fibrocystin isoform 1						cell-cell adhesion|cilium assembly|homeostatic process|kidney development|negative regulation of cellular component movement	anchored to external side of plasma membrane|apical plasma membrane|integral to membrane|microtubule basal body	protein binding|receptor activity			lung(15)|ovary(15)|large_intestine(5)|central_nervous_system(3)|skin(3)|breast(2)|upper_aerodigestive_tract(1)	44	Lung NSC(77;0.0605)					CCTGACCAGTCTAATGTTTCA	0.398		NA											18	50					0	0	0	0
KHDRBS2	202559	broad.mit.edu	37	6	62442586	62442586	+	Splice_Site	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:62442586C>A	uc003peg.2	-	7	1140	c.893_splice	c.e7+1	p.S298_splice		NM_152688	NP_689901	Q5VWX1	KHDR2_HUMAN	KH domain-containing, RNA-binding, signal						regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	SH3 domain binding			skin(7)|ovary(3)|liver(1)	11				BRCA - Breast invasive adenocarcinoma(397;0.149)		AAATGCCTTACCTTTGTGTTT	0.373		NA											29	50					1.08e-15	1.47e-15	1	0
UBE2CBP	90025	broad.mit.edu	37	6	83767585	83767585	+	Silent	SNP	T	T	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:83767585T>G	uc003pjp.2	-	2	342	c.234A>C	c.(232-234)GGA>GGC	p.G78G	UBE2CBP_uc011dyx.1_RNA|UBE2CBP_uc003pjr.2_Silent_p.G46G	NM_198920	NP_944602	Q7Z6J8	UB2CB_HUMAN	ubiquitin-conjugating enzyme E2C binding	78						cytoplasm	ligase activity			ovary(1)	1		all_cancers(76;0.000374)|Acute lymphoblastic leukemia(125;3.85e-06)|all_hematologic(105;0.0017)|all_epithelial(107;0.0548)		BRCA - Breast invasive adenocarcinoma(397;0.0944)		GCAGGTGCAGTCCATCTCCAA	0.463		NA									OREG0017549	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	26					0	0	0	0
BACH2	60468	broad.mit.edu	37	6	90660481	90660481	+	Silent	SNP	A	A	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:90660481A>G	uc011eab.1	-	7	2153	c.1344T>C	c.(1342-1344)TAT>TAC	p.Y448Y	BACH2_uc003pnw.2_Silent_p.Y448Y|BACH2_uc010kch.2_Silent_p.Y448Y	NM_021813	NP_068585	Q9BYV9	BACH2_HUMAN	BTB and CNC homology 1, basic leucine zipper	448						nucleus	protein dimerization activity|sequence-specific DNA binding			ovary(3)|pancreas(1)|lung(1)|skin(1)	6		all_cancers(76;7.37e-06)|Acute lymphoblastic leukemia(125;2.23e-10)|Prostate(29;5.55e-10)|all_hematologic(105;2.42e-06)|all_epithelial(107;0.0063)		BRCA - Breast invasive adenocarcinoma(108;0.0799)		TCACCCCAGAATAAGAATGCA	0.607		NA											36	60					0	0	0	0
FUT9	10690	broad.mit.edu	37	6	96651843	96651843	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:96651843G>T	uc003pop.3	+	3	1153	c.812G>T	c.(811-813)GGA>GTA	p.G271V		NM_006581	NP_006572	Q9Y231	FUT9_HUMAN	fucosyltransferase 9 (alpha (1,3)	271	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane	alpha(1,3)-fucosyltransferase activity			skin(4)|ovary(1)	5		all_cancers(76;4.77e-07)|Acute lymphoblastic leukemia(125;4.01e-09)|all_hematologic(75;1.25e-06)|all_epithelial(107;0.00279)|Colorectal(196;0.0356)		BRCA - Breast invasive adenocarcinoma(108;0.08)		GTTGTTCTGGGACCATCTAGG	0.373		NA											5	35					1.24e-05	1.42e-05	1	0
KLHL32	114792	broad.mit.edu	37	6	97512561	97512561	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:97512561C>A	uc010kcm.1	+	5	842	c.370C>A	c.(370-372)CTG>ATG	p.L124M	KLHL32_uc003poy.2_Missense_Mutation_p.L124M|KLHL32_uc011ead.1_Missense_Mutation_p.L88M|KLHL32_uc003poz.2_Translation_Start_Site|KLHL32_uc011eae.1_Intron|KLHL32_uc003ppa.2_RNA	NM_052904	NP_443136	Q96NJ5	KLH32_HUMAN	kelch-like 32	124										ovary(3)|skin(1)	4		all_cancers(76;1.19e-06)|Acute lymphoblastic leukemia(125;5.83e-10)|all_hematologic(75;3.67e-07)|all_epithelial(107;0.00778)|Colorectal(196;0.122)		BRCA - Breast invasive adenocarcinoma(108;0.0558)		TCACCTACAGCTGTTGGAGCT	0.443		NA											14	32					4.15e-12	5.4e-12	1	0
COL10A1	1300	broad.mit.edu	37	6	116442113	116442113	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:116442113C>T	uc003pwm.2	-	3	1262	c.1166G>A	c.(1165-1167)GGG>GAG	p.G389E	NT5DC1_uc003pwj.2_Intron|NT5DC1_uc003pwk.2_Intron|NT5DC1_uc003pwl.2_Intron	NM_000493	NP_000484	Q03692	COAA1_HUMAN	type X collagen alpha 1 precursor	389	Triple-helical region.				skeletal system development	collagen	metal ion binding			central_nervous_system(1)	1		all_cancers(87;0.0176)|all_epithelial(87;0.0263)|Colorectal(196;0.234)		all cancers(137;0.0157)|OV - Ovarian serous cystadenocarcinoma(136;0.0325)|GBM - Glioblastoma multiforme(226;0.0446)|Epithelial(106;0.0711)		TCCTGGGTACCCTGGTTTTCC	0.597		NA											15	29					0	0	0	0
ROS1	6098	broad.mit.edu	37	6	117629982	117629982	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:117629982G>A	uc003pxp.1	-	41	6743	c.6544C>T	c.(6544-6546)CCA>TCA	p.P2182S	ROS1_uc011ebi.1_RNA	NM_002944	NP_002935	P08922	ROS_HUMAN	proto-oncogene c-ros-1 protein precursor	2182	Protein kinase.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	membrane fraction|sodium:potassium-exchanging ATPase complex	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(8)|ovary(6)|central_nervous_system(3)|skin(3)|stomach(2)|breast(2)|large_intestine(1)	25		all_cancers(87;0.00846)|all_epithelial(87;0.0242)		GBM - Glioblastoma multiforme(226;0.0387)|OV - Ovarian serous cystadenocarcinoma(136;0.0954)|all cancers(137;0.137)		TTTCTTGGTGGCTCCAGTCTC	0.383		NA	T	GOPC|ROS1	glioblastoma|NSCLC								9	40					0	0	0	0
FAM184A	79632	broad.mit.edu	37	6	119337960	119337960	+	Silent	SNP	A	A	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:119337960A>T	uc003pyj.2	-	5	1830	c.1482T>A	c.(1480-1482)ATT>ATA	p.I494I	FAM184A_uc003pyk.3_Silent_p.I374I|FAM184A_uc003pyl.3_Silent_p.I374I	NM_024581	NP_078857	Q8NB25	F184A_HUMAN	hypothetical protein LOC79632 isoform 1	494	Potential.									ovary(2)|central_nervous_system(2)|skin(2)|pancreas(1)	7						GGACAGCTTCAATTGCCATAT	0.343		NA											22	65					0	0	0	0
LAMA2	3908	broad.mit.edu	37	6	129621910	129621910	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:129621910T>A	uc003qbn.2	+	22	3172	c.3067T>A	c.(3067-3069)TGT>AGT	p.C1023S	LAMA2_uc003qbo.2_Missense_Mutation_p.C1023S	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1023	Laminin EGF-like 11.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		GGGTAATAATTGTGACCCAAA	0.423		NA											20	53					0	0	0	0
LAMA2	3908	broad.mit.edu	37	6	129687473	129687473	+	Silent	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:129687473G>T	uc003qbn.2	+	33	4932	c.4827G>T	c.(4825-4827)CTG>CTT	p.L1609L	LAMA2_uc003qbo.2_Silent_p.L1609L	NM_000426	NP_000417	P24043	LAMA2_HUMAN	laminin alpha 2 subunit isoform a precursor	1609	Domain II and I.				cell adhesion|muscle organ development|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development	laminin-1 complex	receptor binding|structural molecule activity			ovary(8)|breast(1)|skin(1)	10				OV - Ovarian serous cystadenocarcinoma(136;0.178)|all cancers(137;0.245)		ATAAAATGCTGTATGGTCTTG	0.522		NA											18	27					2.49e-13	3.3e-13	1	0
ENPP3	5169	broad.mit.edu	37	6	132059244	132059244	+	Silent	SNP	T	T	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:132059244T>C	uc003qcu.3	+	24	2588	c.2241T>C	c.(2239-2241)AGT>AGC	p.S747S	ENPP3_uc010kfq.2_RNA|ENPP3_uc003qcv.2_Silent_p.S747S	NM_005021	NP_005012	O14638	ENPP3_HUMAN	ectonucleotide pyrophosphatase/phosphodiesterase	747	Extracellular (Potential).|Nuclease.				immune response|nucleoside triphosphate catabolic process|phosphate metabolic process	extracellular region|integral to plasma membrane|perinuclear region of cytoplasm	metal ion binding|nucleic acid binding|nucleoside-triphosphate diphosphatase activity|nucleotide diphosphatase activity|phosphodiesterase I activity|polysaccharide binding|scavenger receptor activity			ovary(3)|skin(1)	4	Breast(56;0.0753)			GBM - Glioblastoma multiforme(226;0.0252)|OV - Ovarian serous cystadenocarcinoma(155;0.0511)		ATGTGGTTAGTGGACCAATAT	0.313		NA											7	23					0	0	0	0
GRM1	2911	broad.mit.edu	37	6	146625950	146625950	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:146625950T>C	uc010khw.1	+	4	1624	c.1154T>C	c.(1153-1155)CTG>CCG	p.L385P	GRM1_uc010khv.1_Missense_Mutation_p.L385P|GRM1_uc003qll.2_Missense_Mutation_p.L385P|GRM1_uc011edz.1_Missense_Mutation_p.L385P|GRM1_uc011eea.1_Missense_Mutation_p.L385P	NM_000838	NP_000829	Q13255	GRM1_HUMAN	glutamate receptor, metabotropic 1 isoform alpha	385	Extracellular (Potential).				synaptic transmission	integral to plasma membrane	G-protein coupled receptor activity|glutamate receptor activity			lung(8)|ovary(4)|central_nervous_system(3)|large_intestine(2)|breast(2)	19		Ovarian(120;0.0387)		OV - Ovarian serous cystadenocarcinoma(155;5.35e-08)|GBM - Glioblastoma multiforme(68;0.00762)	Acamprosate(DB00659)|L-Glutamic Acid(DB00142)	GGACACCTTCTGGAAAATCCC	0.443		NA											7	40					0	0	0	0
SYNE1	23345	broad.mit.edu	37	6	152551704	152551704	+	Missense_Mutation	SNP	T	T	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:152551704T>G	uc010kiw.2	-	115	21775	c.21173A>C	c.(21172-21174)CAA>CCA	p.Q7058P	SYNE1_uc010kiv.2_Missense_Mutation_p.Q1582P|SYNE1_uc003qos.3_Missense_Mutation_p.Q1582P|SYNE1_uc003qot.3_Missense_Mutation_p.Q6987P|SYNE1_uc003qou.3_Missense_Mutation_p.Q7058P	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	7058	Cytoplasmic (Potential).|Spectrin 22.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		CAGTGCATTTTGAACAGAAGC	0.383		NA								HNSCC(10;0.0054)			49	157					0	0	0	0
SYNE1	23345	broad.mit.edu	37	6	152652970	152652970	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:152652970C>A	uc010kiw.2	-	78	13452	c.12850G>T	c.(12850-12852)GCA>TCA	p.A4284S	SYNE1_uc003qot.3_Missense_Mutation_p.A4213S|SYNE1_uc003qou.3_Missense_Mutation_p.A4284S|SYNE1_uc010kiz.2_Missense_Mutation_p.A39S	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4284	Cytoplasmic (Potential).|Spectrin 12.				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TCCTGCAATGCCAATGCTAAC	0.373		NA								HNSCC(10;0.0054)			24	84					2.4e-15	3.24e-15	1	0
TCP10L2	401285	broad.mit.edu	37	6	167595300	167595300	+	Nonsense_Mutation	SNP	C	C	T	rs146018563	by1000genomes	TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr6:167595300C>T	uc010kkp.2	+	8	1089	c.958C>T	c.(958-960)CGA>TGA	p.R320*		NM_001145121	NP_001138593	B9ZVM9	B9ZVM9_HUMAN	t-complex 10-like 2	320											0						GGAAGAAAAACGACATCCAAA	0.527		NA											4	62					0	0	0	0
KIAA0415	9907	broad.mit.edu	37	7	4825067	4825067	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:4825067C>A	uc003sne.2	+	8	1036	c.953C>A	c.(952-954)TCC>TAC	p.S318Y	KIAA0415_uc010ksp.2_RNA|KIAA0415_uc003snf.2_5'Flank	NM_014855	NP_055670	O43299	K0415_HUMAN	hypothetical protein LOC9907	318					cell death|double-strand break repair via homologous recombination	cytoplasm|nucleus	protein binding			central_nervous_system(1)	1		Ovarian(82;0.0175)		UCEC - Uterine corpus endometrioid carcinoma (126;0.091)|OV - Ovarian serous cystadenocarcinoma(56;8.35e-15)		AAGGGGGACTCCGACCTGCAG	0.622		NA											14	25					4.75e-09	5.92e-09	1	0
ZNF12	7559	broad.mit.edu	37	7	6731759	6731759	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:6731759T>A	uc003sqt.1	-	5	1368	c.814A>T	c.(814-816)AGT>TGT	p.S272C	ZNF12_uc011jxa.1_Missense_Mutation_p.S110C|ZNF12_uc003sqs.1_Missense_Mutation_p.S234C	NM_016265	NP_057349	P17014	ZNF12_HUMAN	zinc finger protein 12 isoform a	272	C2H2-type 1.				negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Ovarian(82;0.0776)		UCEC - Uterine corpus endometrioid carcinoma (126;0.0231)		CCACATTCACTGCATTCATAG	0.398		NA											13	31					0	0	0	0
ICA1	3382	broad.mit.edu	37	7	8272244	8272244	+	Silent	SNP	G	G	A	rs149823604	byFrequency	TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:8272244G>A	uc003srm.2	-	3	226	c.159C>T	c.(157-159)GAC>GAT	p.D53D	ICA1_uc010ktr.2_Silent_p.D53D|ICA1_uc003srl.2_Silent_p.D41D|ICA1_uc003srn.3_Translation_Start_Site|ICA1_uc003srp.3_Silent_p.D52D|ICA1_uc010kts.2_RNA|ICA1_uc003srq.2_Silent_p.D53D|ICA1_uc003srr.2_Silent_p.D52D|ICA1_uc003sro.3_Silent_p.D53D|ICA1_uc011jxg.1_Silent_p.D53D|ICA1_uc003srs.1_Silent_p.D53D	NM_022307	NP_071682	Q05084	ICA69_HUMAN	islet cell autoantigen 1	53	AH.				neurotransmitter transport	cell junction|cytosol|Golgi membrane|nucleus|secretory granule membrane|synaptic vesicle membrane|transport vesicle membrane				central_nervous_system(1)	1		Ovarian(82;0.0612)		UCEC - Uterine corpus endometrioid carcinoma (126;0.246)		CCAGGTCCGCGTCAGAGGCAA	0.478		NA											3	17					0	0	0	0
DNAH11	8701	broad.mit.edu	37	7	21627744	21627744	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:21627744T>A	uc003svc.2	+	10	1804	c.1773T>A	c.(1771-1773)CAT>CAA	p.H591Q		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	591	Stem (By similarity).				microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						TCAGCCTACATTACAGCACAC	0.368		NA							Kartagener_syndrome				8	16					0	0	0	0
NFE2L3	9603	broad.mit.edu	37	7	26225198	26225198	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:26225198G>T	uc003sxq.2	+	4	2152	c.1880G>T	c.(1879-1881)TGT>TTT	p.C627F		NM_004289	NP_004280	Q9Y4A8	NF2L3_HUMAN	nuclear factor erythroid 2-like 3	627	Leucine-zipper.				transcription from RNA polymerase II promoter	nucleus	protein dimerization activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			skin(3)|ovary(1)	4						CAAGCACAATGTAACAAAGCT	0.343		NA											21	66					3.62e-10	4.6e-10	1	0
BMPER	168667	broad.mit.edu	37	7	34118705	34118705	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:34118705C>A	uc011kap.1	+	12	1429	c.1315C>A	c.(1315-1317)CGC>AGC	p.R439S		NM_133468	NP_597725	Q8N8U9	BMPER_HUMAN	BMP-binding endothelial regulator precursor	439	VWFD.				blood vessel endothelial cell proliferation involved in sprouting angiogenesis|endothelial cell activation|negative regulation of BMP signaling pathway|positive regulation of ERK1 and ERK2 cascade|regulation of endothelial cell migration|regulation of pathway-restricted SMAD protein phosphorylation	extracellular space				ovary(2)|central_nervous_system(1)	3						CCTCACCGTGCGCTGGAACGG	0.662		NA											26	52					4.11e-13	5.45e-13	1	0
ELMO1	9844	broad.mit.edu	37	7	37264526	37264526	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:37264526G>T	uc003tfk.1	-	9	966	c.659C>A	c.(658-660)GCG>GAG	p.A220E	ELMO1_uc011kbc.1_Missense_Mutation_p.A124E|ELMO1_uc010kxg.1_Missense_Mutation_p.A220E	NM_014800	NP_055615	Q92556	ELMO1_HUMAN	engulfment and cell motility 1 isoform 1	220					actin cytoskeleton organization|apoptosis|cellular component movement|phagocytosis, engulfment|Rac protein signal transduction|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|plasma membrane	SH3 domain binding			ovary(3)|skin(2)|upper_aerodigestive_tract(1)	6						GATCTCCTGCGCCACTTTCTG	0.527		NA											21	42					4.35e-09	5.44e-09	1	0
C7orf10	79783	broad.mit.edu	37	7	40277269	40277269	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:40277269G>T	uc003thn.1	+	7	565	c.520G>T	c.(520-522)GGT>TGT	p.G174C	C7orf10_uc003thm.1_Missense_Mutation_p.G144C|C7orf10_uc003tho.1_Missense_Mutation_p.G174C	NM_024728	NP_079004	Q9HAC7	CG010_HUMAN	dermal papilla derived protein 13	181							transferase activity			ovary(2)	2						TCAGCGAGCTGGTTATGATGC	0.423		NA											16	65					8.81e-21	1.24e-20	1	0
ADCY1	107	broad.mit.edu	37	7	45614759	45614759	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:45614759A>T	uc003tne.3	+	1	635	c.617A>T	c.(616-618)AAG>ATG	p.K206M	ADCY1_uc003tnd.2_Translation_Start_Site	NM_021116	NP_066939	Q08828	ADCY1_HUMAN	adenylate cyclase 1	206					activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|calmodulin binding|metal ion binding			ovary(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	6					Adenosine(DB00640)|Adenosine monophosphate(DB00131)|Adenosine triphosphate(DB00171)	GTCCCCGCCAAGCGCCCACGT	0.662		NA											11	16					0	0	0	0
AUTS2	26053	broad.mit.edu	37	7	70255493	70255493	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:70255493G>C	uc003tvw.3	+	19	4034	c.3291G>C	c.(3289-3291)AGG>AGC	p.R1097S	AUTS2_uc003tvx.3_Missense_Mutation_p.R1073S|AUTS2_uc011keg.1_Missense_Mutation_p.R549S	NM_015570	NP_056385	Q8WXX7	AUTS2_HUMAN	autism susceptibility candidate 2 isoform 1	1097										ovary(2)|central_nervous_system(1)	3		all_cancers(73;0.0264)|all_epithelial(88;0.0198)|Lung NSC(55;0.0599)|all_lung(88;0.093)		LUSC - Lung squamous cell carcinoma(90;0.082)|Lung(90;0.186)		TCCTGCTAAGGAACGACCCGC	0.577		NA											7	7					0	0	0	0
PCLO	27445	broad.mit.edu	37	7	82546068	82546068	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:82546068G>T	uc003uhx.2	-	7	11523	c.11234C>A	c.(11233-11235)ACA>AAA	p.T3745K	PCLO_uc003uhv.2_Missense_Mutation_p.T3745K|PCLO_uc010lec.2_Missense_Mutation_p.T710K	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	3676					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						CCTGGAAACTGTGCCCATTGT	0.478		NA											14	41					4.37e-10	5.53e-10	1	0
SEMA3E	9723	broad.mit.edu	37	7	83021872	83021872	+	Silent	SNP	T	T	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:83021872T>G	uc003uhy.1	-	14	2132	c.1666A>C	c.(1666-1668)AGG>CGG	p.R556R		NM_012431	NP_036563	O15041	SEM3E_HUMAN	semaphorin 3E precursor	556					axon guidance	extracellular space|membrane	receptor activity			ovary(3)	3		Medulloblastoma(109;0.109)				ACGTCTCACCTTTTTGCATGT	0.438		NA											16	35					0	0	0	0
ABCB4	5244	broad.mit.edu	37	7	87056134	87056134	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:87056134A>T	uc003uiv.1	-	16	2072	c.1996T>A	c.(1996-1998)TCT>ACT	p.S666T	ABCB4_uc003uiw.1_Missense_Mutation_p.S666T|ABCB4_uc003uix.1_Missense_Mutation_p.S666T	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	666	Cytoplasmic (By similarity).				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					TTCTGAGTAGAATGCCTAAAT	0.383		NA											19	31					0	0	0	0
SLC25A13	10165	broad.mit.edu	37	7	95775870	95775870	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:95775870T>C	uc003uof.3	-	14	1641	c.1450A>G	c.(1450-1452)AAG>GAG	p.K484E	SLC25A13_uc003uog.3_Missense_Mutation_p.K485E|SLC25A13_uc011kik.1_Missense_Mutation_p.K376E	NM_014251	NP_055066	Q9UJS0	CMC2_HUMAN	solute carrier family 25, member 13 isoform 2	484	Solcar 2.				ATP biosynthetic process|gluconeogenesis|malate-aspartate shuttle|response to calcium ion	integral to plasma membrane|mitochondrial inner membrane	calcium ion binding|L-aspartate transmembrane transporter activity|L-glutamate transmembrane transporter activity			central_nervous_system(3)|skin(1)	4	all_cancers(62;7.75e-08)|all_epithelial(64;1.16e-07)		STAD - Stomach adenocarcinoma(171;0.194)		L-Aspartic Acid(DB00128)	AAAGTTACCTTGTAGATCCCA	0.388		NA											27	71					0	0	0	0
STAG3	10734	broad.mit.edu	37	7	99787212	99787212	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:99787212G>T	uc003utx.1	+	8	1015	c.860G>T	c.(859-861)CGC>CTC	p.R287L	STAG3_uc010lgs.1_Missense_Mutation_p.R75L|STAG3_uc011kjk.1_Missense_Mutation_p.R229L	NM_012447	NP_036579	Q9UJ98	STAG3_HUMAN	stromal antigen 3	287					chromosome segregation|synaptonemal complex assembly	chromosome, centromeric region|meiotic cohesin complex|synaptonemal complex	binding			ovary(4)|skin(2)|lung(1)|kidney(1)	8	Lung NSC(181;0.0181)|all_lung(186;0.0284)|Esophageal squamous(72;0.0439)					TTGGAGAAACGCAAAGAGGTG	0.547		NA											19	101					0.000720815	0.00078473	1	0
CFTR	1080	broad.mit.edu	37	7	117251690	117251690	+	Silent	SNP	T	T	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:117251690T>A	uc003vjd.2	+	20	3327	c.3195T>A	c.(3193-3195)CTT>CTA	p.L1065L	CFTR_uc011knq.1_Silent_p.L471L	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	1065	Cytoplasmic (Potential).|ABC transmembrane type-1 2.		L -> R (in CF).|L -> P (in CF).		respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	TATGGACACTTCGTGCCTTCG	0.413		NA							Cystic_Fibrosis				6	21					0	0	0	0
KCND2	3751	broad.mit.edu	37	7	119915618	119915618	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:119915618G>A	uc003vjj.1	+	1	1897	c.932G>A	c.(931-933)CGC>CAC	p.R311H		NM_012281	NP_036413	Q9NZV8	KCND2_HUMAN	potassium voltage-gated channel, Shal-related	311	Cytoplasmic (Potential).				regulation of action potential|synaptic transmission	cell surface|dendritic spine	metal ion binding			ovary(2)|central_nervous_system(2)|skin(1)	5	all_neural(327;0.117)					CAAGGCCTGCGCATCCTGGGG	0.507		NA											20	59					0	0	0	0
DGKI	9162	broad.mit.edu	37	7	137308275	137308275	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:137308275T>C	uc003vtt.2	-	7	831	c.830A>G	c.(829-831)CAC>CGC	p.H277R	DGKI_uc003vtu.2_5'UTR	NM_004717	NP_004708	O75912	DGKI_HUMAN	diacylglycerol kinase, iota	277	Phorbol-ester/DAG-type 2.				activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway|intracellular signal transduction|platelet activation	nucleus|plasma membrane	ATP binding|diacylglycerol kinase activity|metal ion binding			ovary(1)|kidney(1)|skin(1)	3						CTCTTTACTGTGGAAGGAGAA	0.443		NA											35	91					0	0	0	0
AKR1D1	6718	broad.mit.edu	37	7	137790055	137790055	+	Silent	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:137790055G>T	uc003vtz.2	+	5	528	c.459G>T	c.(457-459)GCG>GCT	p.A153A	AKR1D1_uc011kqb.1_Silent_p.A153A|AKR1D1_uc011kqc.1_RNA|AKR1D1_uc011kqd.1_RNA|AKR1D1_uc011kqe.1_Silent_p.A153A|AKR1D1_uc011kqf.1_Intron|AKR1D1_uc010lmy.1_RNA	NM_005989	NP_005980	P51857	AK1D1_HUMAN	aldo-keto reductase family 1, member D1	153					androgen metabolic process|bile acid biosynthetic process|bile acid catabolic process|C21-steroid hormone metabolic process|cholesterol catabolic process|digestion	cytosol	aldo-keto reductase (NADP) activity|delta4-3-oxosteroid 5beta-reductase activity|steroid binding			skin(1)	1						CTCTACAGGCGATGGAAGCTT	0.453		NA											47	135					1.36e-18	1.9e-18	1	0
TAS2R40	259286	broad.mit.edu	37	7	142919874	142919874	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:142919874A>T	uc011ksx.1	+	1	703	c.703A>T	c.(703-705)AGG>TGG	p.R235W		NM_176882	NP_795363	P59535	T2R40_HUMAN	taste receptor, type 2, member 40	235	Cytoplasmic (Potential).				sensory perception of taste	integral to membrane	G-protein coupled receptor activity			ovary(1)	1	Melanoma(164;0.059)					CACAGGGTCCAGGGACCCCAG	0.507		NA											28	76					0	0	0	0
SSPO	23145	broad.mit.edu	37	7	149517793	149517793	+	Missense_Mutation	SNP	G	G	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:149517793G>C	uc010lpk.2	+	87	12230	c.12230G>C	c.(12229-12231)CGC>CCC	p.R4077P	SSPO_uc010lpm.1_5'Flank|SSPO_uc003wgg.2_5'Flank|SSPO_uc003wgh.2_5'Flank|SSPO_uc003wgi.1_5'Flank	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	4077					cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CGCTGCCCCCGCCGCTGCTCA	0.657		NA											4	17					0	0	0	0
AGAP3	116988	broad.mit.edu	37	7	150814821	150814821	+	Silent	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:150814821C>T	uc003wjg.1	+	5	666	c.663C>T	c.(661-663)TTC>TTT	p.F221F	AGAP3_uc003wje.1_5'UTR|AGAP3_uc003wjf.1_Silent_p.F221F|AGAP3_uc010lpy.1_Silent_p.F221F|AGAP3_uc003wjh.1_Silent_p.F401F	NM_031946	NP_114152	Q96P47	AGAP3_HUMAN	centaurin, gamma 3 isoform a	185	Small GTPase-like.				regulation of ARF GTPase activity|small GTPase mediated signal transduction	cytoplasm|membrane	ARF GTPase activator activity|GTP binding|GTPase activity|zinc ion binding			central_nervous_system(2)|ovary(1)	3						TCTGCAGCTTCCGCAACGCCA	0.602		NA											39	88					0	0	0	0
SOX7	83595	broad.mit.edu	37	8	10583720	10583720	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:10583720C>T	uc003wtf.2	-	2	774	c.695G>A	c.(694-696)CGC>CAC	p.R232H	SOX7_uc011kwz.1_Missense_Mutation_p.R284H	NM_031439	NP_113627	Q9BT81	SOX7_HUMAN	SRY-box 7	232					endoderm formation|negative regulation of cell proliferation|negative regulation of transcription, DNA-dependent|positive regulation of caspase activity|regulation of canonical Wnt receptor signaling pathway	cytoplasm|nucleus	transcription regulatory region DNA binding			breast(1)	1				COAD - Colon adenocarcinoma(149;0.0732)		GGGGATGCGGCGGGGATGGCC	0.682		NA											17	14					0	0	0	0
MTMR7	9108	broad.mit.edu	37	8	17206577	17206577	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:17206577T>C	uc003wxm.2	-	5	721	c.482A>G	c.(481-483)TAT>TGT	p.Y161C	MTMR7_uc003wxn.2_5'UTR	NM_004686	NP_004677	Q9Y216	MTMR7_HUMAN	myotubularin related protein 7	161	Myotubularin phosphatase.						protein tyrosine phosphatase activity			skin(1)	1				Colorectal(111;0.112)		TTCAGTAGGATAAGAGTCACA	0.473		NA											16	46					0	0	0	0
NAT1	9	broad.mit.edu	37	8	18079810	18079810	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:18079810A>T	uc010ltd.2	+	5	621	c.254A>T	c.(253-255)GAG>GTG	p.E85V	NAT1_uc003wyt.2_Missense_Mutation_p.E147V|NAT1_uc003wyu.2_Missense_Mutation_p.E85V|NAT1_uc003wyv.2_Missense_Mutation_p.E85V|NAT1_uc010ltc.2_Missense_Mutation_p.E85V|NAT1_uc003wys.2_Missense_Mutation_p.E147V|NAT1_uc003wyr.2_Missense_Mutation_p.E85V|NAT1_uc003wyq.2_Missense_Mutation_p.E85V|NAT1_uc011kyl.1_Missense_Mutation_p.E85V	NM_001160179	NP_001153651	P18440	ARY1_HUMAN	N-acetyltransferase 1 isoform a	85					xenobiotic metabolic process	cytosol	arylamine N-acetyltransferase activity				0				Colorectal(111;0.0519)|COAD - Colon adenocarcinoma(73;0.208)		ATTGGTTTTGAGACCACGATG	0.473		NA											39	53					0	0	0	0
KIF13B	23303	broad.mit.edu	37	8	29006204	29006204	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:29006204G>A	uc003xhh.3	-	16	1762	c.1703C>T	c.(1702-1704)TCT>TTT	p.S568F	KIF13B_uc003xhj.2_Missense_Mutation_p.S465F|KIF13B_uc010lvf.1_Missense_Mutation_p.S504F	NM_015254	NP_056069	Q9NQT8	KI13B_HUMAN	kinesin family member 13B	568					microtubule-based movement|protein targeting|signal transduction|T cell activation	cytoplasm|microtubule	ATP binding|microtubule motor activity|protein kinase binding				0		Ovarian(32;0.000536)		KIRC - Kidney renal clear cell carcinoma(542;0.152)|Kidney(114;0.181)		CAGCTGCTCAGAACTATTCTC	0.463		NA											26	52					0	0	0	0
OPRK1	4986	broad.mit.edu	37	8	54147356	54147356	+	Silent	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:54147356G>T	uc003xrh.1	-	2	948	c.573C>A	c.(571-573)ATC>ATA	p.I191I	OPRK1_uc003xri.1_Silent_p.I191I|OPRK1_uc010lyc.1_Silent_p.I102I	NM_000912	NP_000903	P41145	OPRK_HUMAN	opioid receptor, kappa 1	191	Helical; Name=4; (Potential).				behavior|immune response|inhibition of adenylate cyclase activity by G-protein signaling pathway|sensory perception|synaptic transmission|viral genome replication	integral to plasma membrane	kappa-opioid receptor activity|protein binding			ovary(1)|skin(1)	2		all_epithelial(80;0.066)|Lung NSC(129;0.0804)|all_lung(136;0.136)			Buprenorphine(DB00921)|Butorphanol(DB00611)|Cocaine(DB00907)|Codeine(DB00318)|Dezocine(DB01209)|Hydrocodone(DB00956)|Hydromorphone(DB00327)|Meperidine(DB00454)|Mirtazapine(DB00370)|Morphine(DB00295)|Nalbuphine(DB00844)|Naltrexone(DB00704)|Oxycodone(DB00497)|Pentazocine(DB00652)|Propoxyphene(DB00647)|Tramadol(DB00193)	CTATTGCAGAGATGCCAACAG	0.448		NA											18	83					6.5e-13	8.57e-13	1	0
CHD7	55636	broad.mit.edu	37	8	61765575	61765575	+	Silent	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:61765575C>T	uc003xue.2	+	31	6768	c.6291C>T	c.(6289-6291)GAC>GAT	p.D2097D		NM_017780	NP_060250	Q9P2D1	CHD7_HUMAN	chromodomain helicase DNA binding protein 7	2097					central nervous system development|chromatin modification|cognition|cranial nerve development|face development|heart morphogenesis|in utero embryonic development|inner ear morphogenesis|nose development|palate development|regulation of growth hormone secretion|regulation of transcription, DNA-dependent|retina development in camera-type eye|skeletal system development|T cell differentiation|transcription, DNA-dependent	nucleus	ATP binding|chromatin binding|DNA binding|helicase activity			ovary(4)|large_intestine(1)|central_nervous_system(1)|lung(1)|breast(1)|pancreas(1)	9		all_cancers(86;0.2)|all_lung(136;0.0402)|Lung NSC(129;0.0459)|all_epithelial(80;0.0477)	BRCA - Breast invasive adenocarcinoma(89;0.143)			GACGGCATGACCGAGACTTGC	0.547		NA											16	20					0	0	0	0
SULF1	23213	broad.mit.edu	37	8	70512983	70512983	+	Nonsense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:70512983G>T	uc010lza.1	+	9	1597	c.880G>T	c.(880-882)GAG>TAG	p.E294*	SULF1_uc003xyd.2_Nonsense_Mutation_p.E294*|SULF1_uc003xye.2_Nonsense_Mutation_p.E294*|SULF1_uc003xyf.2_Nonsense_Mutation_p.E294*|SULF1_uc003xyg.2_Nonsense_Mutation_p.E294*|SULF1_uc003xyh.1_RNA	NM_015170	NP_055985	Q8IWU6	SULF1_HUMAN	sulfatase 1 precursor	294					apoptosis|bone development|heparan sulfate proteoglycan metabolic process|kidney development|negative regulation of fibroblast growth factor receptor signaling pathway	cell surface|endoplasmic reticulum|extracellular space|Golgi stack	arylsulfatase activity|calcium ion binding			central_nervous_system(3)|ovary(2)|pancreas(1)|skin(1)	7	Breast(64;0.0654)		Epithelial(68;0.0124)|OV - Ovarian serous cystadenocarcinoma(28;0.0265)|all cancers(69;0.0534)			TGATTCTGTGGAGAGGGTAAG	0.443		NA											31	118					2.47e-13	3.29e-13	1	0
ZFHX4	79776	broad.mit.edu	37	8	77764098	77764098	+	Silent	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:77764098G>A	uc003yav.2	+	10	5193	c.4806G>A	c.(4804-4806)CAG>CAA	p.Q1602Q	ZFHX4_uc003yau.1_Silent_p.Q1647Q|ZFHX4_uc003yaw.1_Silent_p.Q1602Q	NM_024721	NP_078997	Q86UP3	ZFHX4_HUMAN	zinc finger homeodomain 4	1602						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(8)|large_intestine(4)|breast(2)|lung(1)	15			BRCA - Breast invasive adenocarcinoma(89;0.0895)			GCCCTGGCCAGGGGATGTTAG	0.473		NA								HNSCC(33;0.089)			12	50					0	0	0	0
IMPA1	3612	broad.mit.edu	37	8	82591364	82591364	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:82591364T>C	uc003ych.2	-	4	426	c.299A>G	c.(298-300)CAT>CGT	p.H100R	IMPA1_uc011lfq.1_Missense_Mutation_p.H159R|IMPA1_uc011lfr.1_Missense_Mutation_p.H100R	NM_005536	NP_005527	P29218	IMPA1_HUMAN	inositol(myo)-1(or 4)-monophosphatase 1 isoform	100					inositol phosphate dephosphorylation|phosphatidylinositol biosynthetic process|signal transduction	cytoplasm	inositol-1(or 4)-monophosphatase activity|metal ion binding|protein homodimerization activity			skin(1)	1					Lithium(DB01356)	AACATACCTATGTACAAAGTT	0.338		NA											25	32					0	0	0	0
CA3	761	broad.mit.edu	37	8	86351946	86351946	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:86351946G>T	uc003ydj.2	+	2	123	c.40G>T	c.(40-42)GAC>TAC	p.D14Y	CA13_uc003ydf.1_RNA|CA3_uc011lfv.1_RNA	NM_005181	NP_005172	P07451	CAH3_HUMAN	carbonic anhydrase III	14					one-carbon metabolic process	cytoplasm	carbonate dehydratase activity|zinc ion binding				0						CCTAGGTCCTGACCACTGGCA	0.473		NA											8	68					7.48e-07	8.88e-07	1	0
RUNX1T1	862	broad.mit.edu	37	8	92998530	92998530	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:92998530C>A	uc003yfd.2	-	8	1185	c.1101G>T	c.(1099-1101)ATG>ATT	p.M367I	RUNX1T1_uc003yfc.1_Missense_Mutation_p.M340I|RUNX1T1_uc003yfe.1_Missense_Mutation_p.M330I|RUNX1T1_uc010mao.2_Missense_Mutation_p.M340I|RUNX1T1_uc011lgi.1_Missense_Mutation_p.M378I|RUNX1T1_uc010man.1_5'UTR|RUNX1T1_uc003yfb.1_Missense_Mutation_p.M330I	NM_175634	NP_783552	Q06455	MTG8_HUMAN	acute myelogenous leukemia 1 translocation 1	367	Important for oligomerization.				generation of precursor metabolites and energy	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(9)|large_intestine(3)|breast(2)|central_nervous_system(1)|pancreas(1)	16			BRCA - Breast invasive adenocarcinoma(11;0.0141)			TTTTTTCTACCATGTCCATTA	0.438		NA											38	71					1.47e-24	2.1e-24	1	0
PTDSS1	9791	broad.mit.edu	37	8	97321822	97321822	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:97321822C>T	uc003yht.1	+	9	1147	c.1045C>T	c.(1045-1047)CGC>TGC	p.R349C	PTDSS1_uc003yhu.1_Missense_Mutation_p.R203C	NM_014754	NP_055569	P48651	PTSS1_HUMAN	phosphatidylserine synthase 1	349					phosphatidylserine biosynthetic process	integral to membrane	transferase activity			ovary(1)	1	Breast(36;6.18e-05)				Phosphatidylserine(DB00144)	ACAGTGCAAGCGCGTAGGAAC	0.423		NA											13	43					0	0	0	0
UBR5	51366	broad.mit.edu	37	8	103326146	103326146	+	Splice_Site	SNP	T	T	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:103326146T>C	uc003ykr.1	-	16	1928	c.1895_splice	c.e16-1	p.K632_splice	UBR5_uc003yks.1_Splice_Site_p.K632_splice	NM_015902	NP_056986	O95071	UBR5_HUMAN	ubiquitin protein ligase E3 component n-recognin						cell proliferation|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of catenin import into nucleus|positive regulation of protein import into nucleus, translocation|progesterone receptor signaling pathway|protein polyubiquitination|protein ubiquitination involved in ubiquitin-dependent protein catabolic process|response to DNA damage stimulus	nucleus|soluble fraction	protein binding|RNA binding|ubiquitin-ubiquitin ligase activity|zinc ion binding			lung(16)|ovary(4)|large_intestine(3)|breast(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|kidney(1)	28	all_cancers(14;8e-07)|all_epithelial(15;2.18e-08)|Lung NSC(17;2.55e-05)|all_lung(17;8.85e-05)		OV - Ovarian serous cystadenocarcinoma(57;0.000442)			GTCGTCGTTCTTAGACAACAA	0.363		NA											14	100					0	0	0	0
CSMD3	114788	broad.mit.edu	37	8	113256715	113256715	+	Missense_Mutation	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:113256715G>A	uc003ynu.2	-	65	10469	c.10310C>T	c.(10309-10311)ACC>ATC	p.T3437I	CSMD3_uc003yns.2_Missense_Mutation_p.T2639I|CSMD3_uc003ynt.2_Missense_Mutation_p.T3397I|CSMD3_uc011lhx.1_Missense_Mutation_p.T3268I	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3437	Extracellular (Potential).|Sushi 28.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AGGCTGACAGGTATAAATCAG	0.438		NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			23	61					0	0	0	0
CSMD3	114788	broad.mit.edu	37	8	113318355	113318355	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:113318355C>G	uc003ynu.2	-	51	8111	c.7952G>C	c.(7951-7953)GGA>GCA	p.G2651A	CSMD3_uc003yns.2_Missense_Mutation_p.G1853A|CSMD3_uc003ynt.2_Missense_Mutation_p.G2611A|CSMD3_uc011lhx.1_Missense_Mutation_p.G2547A	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	2651	Extracellular (Potential).|Sushi 15.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						AACTCGCGTTCCTACCAAATA	0.378		NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			10	53					0	0	0	0
CSMD3	114788	broad.mit.edu	37	8	113569034	113569034	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:113569034C>A	uc003ynu.2	-	25	4351	c.4192G>T	c.(4192-4194)GGG>TGG	p.G1398W	CSMD3_uc003yns.2_Missense_Mutation_p.G670W|CSMD3_uc003ynt.2_Missense_Mutation_p.G1358W|CSMD3_uc011lhx.1_Missense_Mutation_p.G1294W	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	1398	Extracellular (Potential).|Sushi 7.					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						CTTCTCTCCCCTGTCATGCAC	0.438		NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			12	57					0.00010058	0.000112833	1	0
UTP23	84294	broad.mit.edu	37	8	117782554	117782554	+	Silent	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:117782554G>T	uc003yoc.2	+	2	413	c.312G>T	c.(310-312)CTG>CTT	p.L104L		NM_032334	NP_115710	Q9BRU9	UTP23_HUMAN	UTP23, small subunit (SSU) processome component,	104					rRNA processing	nucleolus					0						CAGAATGTCTGCTTTCCATGG	0.378		NA											63	94					6.29e-36	9.09e-36	1	0
ADCY8	114	broad.mit.edu	37	8	132051742	132051742	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:132051742C>A	uc003ytd.3	-	1	1094	c.838G>T	c.(838-840)GCC>TCC	p.A280S	ADCY8_uc010mds.2_Missense_Mutation_p.A280S	NM_001115	NP_001106	P40145	ADCY8_HUMAN	adenylate cyclase 8	280	Helical; (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	integral to membrane|membrane fraction|plasma membrane	ATP binding|calcium- and calmodulin-responsive adenylate cyclase activity|metal ion binding			skin(4)|large_intestine(1)|central_nervous_system(1)	6	Esophageal squamous(12;0.00693)|Ovarian(258;0.00707)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.000538)			CTGTAGGTGGCGAAGAGCGTG	0.667		NA								HNSCC(32;0.087)			15	54					1.52e-12	2e-12	1	0
SLA	6503	broad.mit.edu	37	8	134057291	134057291	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:134057291C>A	uc003ytz.2	-	7	1254	c.422G>T	c.(421-423)TGG>TTG	p.W141L	TG_uc003ytw.2_Intron|TG_uc010mdw.2_Intron|TG_uc011ljb.1_Intron|TG_uc011ljc.1_Intron|SLA_uc011lje.1_Missense_Mutation_p.W158L|SLA_uc011ljf.1_Missense_Mutation_p.W33L|SLA_uc011ljg.1_Intron|SLA_uc011ljd.1_Missense_Mutation_p.W181L	NM_001045556	NP_001039021	Q13239	SLAP1_HUMAN	Src-like-adaptor isoform a	141	SH2.					endosome	SH3/SH2 adaptor activity			lung(1)|liver(1)	2	all_epithelial(106;3.51e-21)|Lung NSC(106;4.24e-06)|Ovarian(258;0.00438)|Acute lymphoblastic leukemia(118;0.155)	Myeloproliferative disorder(644;0.00878)|Acute lymphoblastic leukemia(644;0.0279)|Breast(495;0.037)	BRCA - Breast invasive adenocarcinoma(115;0.000701)			AATGTAGTACCAGTTGTTGGG	0.512		NA											16	68					1.57e-10	2.01e-10	1	0
C8orf31	286122	broad.mit.edu	37	8	144130634	144130634	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:144130634C>G	uc003yxp.1	+	5	716	c.364C>G	c.(364-366)CGG>GGG	p.R122G	C8orf31_uc003yxq.1_RNA|C8orf31_uc003yxr.1_RNA	NM_173687	NP_775958	Q8N9H6	CH031_HUMAN	hypothetical protein LOC286122	122										ovary(1)	1	all_cancers(97;1.89e-10)|all_epithelial(106;8.73e-09)|Lung NSC(106;0.000161)|all_lung(105;0.000447)|Ovarian(258;0.0254)|Acute lymphoblastic leukemia(118;0.155)					aggattctctcggcaccacgg	0.02		NA											49	75					0	0	0	0
NRBP2	340371	broad.mit.edu	37	8	144921093	144921093	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr8:144921093C>T	uc011lkt.1	-	9	846	c.706G>A	c.(706-708)GCT>ACT	p.A236T	NRBP2_uc003yzv.2_5'UTR|NRBP2_uc003yzz.1_5'Flank|NRBP2_uc003yzw.2_5'Flank|NRBP2_uc010mfl.2_5'Flank|NRBP2_uc010mfm.2_5'UTR|NRBP2_uc011lks.1_5'UTR|NRBP2_uc003yzy.2_5'UTR	NM_178564	NP_848659	Q9NSY0	NRBP2_HUMAN	nuclear receptor binding protein 2	236	Protein kinase.				negative regulation of neuron apoptosis|neuron differentiation	cytoplasm	ATP binding|protein kinase activity			central_nervous_system(2)	2	all_cancers(97;2.31e-11)|all_epithelial(106;1.58e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;1.23e-39)|all cancers(56;6.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.18)			ATGTCCACAGCGGTCCCATCG	0.632		NA											10	24					0	0	0	0
PTPRD	5789	broad.mit.edu	37	9	8636759	8636759	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr9:8636759G>T	uc003zkk.2	-	12	861	c.150C>A	c.(148-150)GAC>GAA	p.D50E	PTPRD_uc003zkp.2_Missense_Mutation_p.D50E|PTPRD_uc003zkq.2_Missense_Mutation_p.D50E|PTPRD_uc003zkr.2_Missense_Mutation_p.D50E|PTPRD_uc003zks.2_Missense_Mutation_p.D50E|PTPRD_uc003zkl.2_Missense_Mutation_p.D50E|PTPRD_uc003zkm.2_Missense_Mutation_p.D50E|PTPRD_uc003zkn.2_Missense_Mutation_p.D50E|PTPRD_uc003zko.2_Missense_Mutation_p.D50E|PTPRD_uc003zkt.1_Missense_Mutation_p.D50E	NM_002839	NP_002830	P23468	PTPRD_HUMAN	protein tyrosine phosphatase, receptor type, D	50	Ig-like C2-type 1.|Extracellular (Potential).				transmembrane receptor protein tyrosine phosphatase signaling pathway	integral to plasma membrane	protein binding|transmembrane receptor protein tyrosine phosphatase activity			lung(14)|large_intestine(3)|ovary(2)|breast(2)|urinary_tract(1)	22		all_cancers(3;3.38e-95)|all_epithelial(3;2.84e-91)|all_lung(3;7.3e-56)|Lung NSC(3;1.82e-52)|Renal(3;3.42e-19)|all_hematologic(3;0.000134)|all_neural(3;0.00409)|Acute lymphoblastic leukemia(23;0.0069)|Melanoma(3;0.0121)|Myeloproliferative disorder(4;0.0122)|Medulloblastoma(3;0.0144)|Lung SC(3;0.0301)|Ovarian(56;0.0694)|Hepatocellular(3;0.0824)		all cancers(1;3.38e-12)|Epithelial(1;2.12e-09)|STAD - Stomach adenocarcinoma(1;1.29e-07)|KIRC - Kidney renal clear cell carcinoma(3;5.49e-07)|Kidney(3;6.36e-07)|GBM - Glioblastoma multiforme(50;9.05e-05)|Lung(1;0.000189)|BRCA - Breast invasive adenocarcinoma(1;0.00178)|LUSC - Lung squamous cell carcinoma(1;0.0115)|LUAD - Lung adenocarcinoma(58;0.119)		TAGGTCTTGGGTCTCCCGTAG	0.443		NA								TSP Lung(15;0.13)			12	47					5.51e-06	6.36e-06	1	0
C9orf82	79886	broad.mit.edu	37	9	26861107	26861107	+	Silent	SNP	G	G	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr9:26861107G>A	uc003zqc.2	-	5	708	c.696C>T	c.(694-696)TCC>TCT	p.S232S	C9orf82_uc003zqb.2_Silent_p.S87S	NM_024828	NP_079104	Q9H8G2	CI082_HUMAN	hypothetical protein LOC79886	232											0		all_neural(3;3.53e-10)|Glioma(3;2.71e-09)		Lung(42;1.39e-05)|LUSC - Lung squamous cell carcinoma(38;0.000114)		TCTCTCTCACGGATGAAGCAG	0.323		NA											35	45					0	0	0	0
CEP78	84131	broad.mit.edu	37	9	80880327	80880327	+	Silent	SNP	A	A	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr9:80880327A>C	uc004akx.2	+	14	1941	c.1665A>C	c.(1663-1665)TCA>TCC	p.S555S	CEP78_uc004aky.3_Silent_p.S556S|CEP78_uc010mpp.2_Silent_p.S556S|CEP78_uc004akz.1_Silent_p.S43S	NM_032171	NP_115547	Q5JTW2	CEP78_HUMAN	centrosomal protein 78kDa isoform b	555					G2/M transition of mitotic cell cycle	centrosome|cytosol				ovary(1)	1						TAGATCAGTCAGATTTTCAAT	0.438		NA											2	2					0	0	0	0
INVS	27130	broad.mit.edu	37	9	103002466	103002466	+	Missense_Mutation	SNP	A	A	G	rs41312220	byFrequency	TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr9:103002466A>G	uc004bap.1	+	6	952	c.740A>G	c.(739-741)AAT>AGT	p.N247S	INVS_uc010mta.1_Missense_Mutation_p.N151S|INVS_uc011lve.1_Missense_Mutation_p.N151S|INVS_uc004bao.1_Missense_Mutation_p.N247S|INVS_uc004baq.1_Missense_Mutation_p.N151S|INVS_uc004bar.1_Missense_Mutation_p.N151S|INVS_uc010mtb.1_5'UTR	NM_014425	NP_055240	Q9Y283	INVS_HUMAN	inversin isoform a	247	ANK 7.				negative regulation of canonical Wnt receptor signaling pathway|Wnt receptor signaling pathway	cytoplasm|membrane|microtubule|nucleus|spindle	calmodulin binding			ovary(2)	2		Acute lymphoblastic leukemia(62;0.056)				GAAAGCTGCAATATAACGTCT	0.438		NA											4	59					0	0	0	0
EPB41L4B	54566	broad.mit.edu	37	9	111970306	111970306	+	Silent	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr9:111970306C>T	uc004bdz.1	-	18	2071	c.1776G>A	c.(1774-1776)GAG>GAA	p.E592E		NM_019114	NP_061987	Q9H329	E41LB_HUMAN	erythrocyte membrane protein band 4.1 like 4B	592						cytoplasm|cytoskeleton|extrinsic to membrane	cytoskeletal protein binding|structural constituent of cytoskeleton			ovary(1)|central_nervous_system(1)|skin(1)	3						GAAGAGTTTTCTCCGAGACTT	0.413		NA											18	39					0	0	0	0
MUSK	4593	broad.mit.edu	37	9	113562629	113562629	+	Nonsense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr9:113562629C>A	uc004bey.2	+	14	2069	c.1971C>A	c.(1969-1971)TAC>TAA	p.Y657*	MUSK_uc004bez.1_Nonsense_Mutation_p.Y237*	NM_005592	NP_005583	O15146	MUSK_HUMAN	skeletal muscle receptor tyrosine kinase	657	Protein kinase.|Cytoplasmic (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|ovary(2)|central_nervous_system(1)	6						TCTTTGAATACATGGCCTATG	0.507		NA											31	45					8.89e-20	1.25e-19	1	0
PTGS1	5742	broad.mit.edu	37	9	125145892	125145892	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr9:125145892G>T	uc004bmg.1	+	8	1002	c.867G>T	c.(865-867)GAG>GAT	p.E289D	PTGS1_uc011lys.1_Missense_Mutation_p.E264D|PTGS1_uc010mwb.1_Missense_Mutation_p.E180D|PTGS1_uc004bmf.1_Missense_Mutation_p.E289D|PTGS1_uc004bmh.1_Missense_Mutation_p.E180D|PTGS1_uc011lyt.1_Missense_Mutation_p.E180D	NM_000962	NP_000953	P23219	PGH1_HUMAN	prostaglandin-endoperoxide synthase 1 isoform 1	289					cyclooxygenase pathway|hormone biosynthetic process|regulation of blood pressure|response to oxidative stress|xenobiotic metabolic process	endoplasmic reticulum membrane|Golgi apparatus|microsome|plasma membrane	heme binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|peroxidase activity|prostaglandin-endoperoxide synthase activity			ovary(1)|skin(1)	2					Acetaminophen(DB00316)|Aspirin(DB00945)|Balsalazide(DB01014)|Bromfenac(DB00963)|Ciclopirox(DB01188)|Diclofenac(DB00586)|Diflunisal(DB00861)|Dipyrone(DB04817)|Etodolac(DB00749)|Fenoprofen(DB00573)|Flurbiprofen(DB00712)|gamma-Homolinolenic acid(DB00154)|Ibuprofen(DB01050)|Icosapent(DB00159)|Indomethacin(DB00328)|Ketoprofen(DB01009)|Ketorolac(DB00465)|Lumiracoxib(DB01283)|Meclofenamic acid(DB00939)|Mefenamic acid(DB00784)|Mesalazine(DB00244)|Minoxidil(DB00350)|Nabumetone(DB00461)|Naproxen(DB00788)|Phenacetin(DB03783)|Piroxicam(DB00554)|Rofecoxib(DB00533)|Salicyclic acid(DB00936)|Salsalate(DB01399)|Sulindac(DB00605)|Suprofen(DB00870)|Tenoxicam(DB00469)|Tolmetin(DB00500)	TGGGCCAGGAGGTGTTTGGGC	0.622		NA											18	43					2.94e-08	3.59e-08	1	0
GBGT1	26301	broad.mit.edu	37	9	136029278	136029278	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr9:136029278T>A	uc004ccw.2	-	7	1011	c.730A>T	c.(730-732)AGG>TGG	p.R244W	RALGDS_uc011mcw.1_Intron|GBGT1_uc004ccx.2_Missense_Mutation_p.R197W|GBGT1_uc010nab.2_3'UTR|GBGT1_uc011mcx.1_Missense_Mutation_p.R227W|GBGT1_uc010nac.1_Missense_Mutation_p.R108W|GBGT1_uc004ccy.1_3'UTR	NM_021996	NP_068836	Q8N5D6	GBGT1_HUMAN	globoside	244	Lumenal (Potential).				carbohydrate metabolic process|glycolipid biosynthetic process	Golgi membrane|integral to membrane	metal ion binding				0				OV - Ovarian serous cystadenocarcinoma(145;3.49e-06)|Epithelial(140;2.59e-05)		GAAACACGCCTGCGCTCATAG	0.597		NA											32	56					0	0	0	0
CACNA1B	774	broad.mit.edu	37	9	140772650	140772650	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr9:140772650A>G	uc004cog.2	+	1	410	c.265A>G	c.(265-267)AAG>GAG	p.K89E	uc004cof.1_Intron	NM_000718	NP_000709	Q00975	CAC1B_HUMAN	calcium channel, voltage-dependent, N type,	89	Cytoplasmic (Potential).|I.				membrane depolarization|synaptic transmission	voltage-gated calcium channel complex	ATP binding|protein C-terminus binding|voltage-gated calcium channel activity			breast(3)|large_intestine(2)|ovary(1)	6	all_cancers(76;0.166)			OV - Ovarian serous cystadenocarcinoma(145;1.16e-05)|Epithelial(140;0.000476)	Amlodipine(DB00381)|Gabapentin(DB00996)	CAAATACGCGAAGCGCATCAC	0.423		NA											4	9					0	0	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	28807464	28807464	+	Nonsense_Mutation	SNP	A	A	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chrX:28807464A>T	uc004dby.2	+	2	512	c.4A>T	c.(4-6)AAA>TAA	p.K2*		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	interleukin 1 receptor accessory protein-like 1	2					innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity			ovary(3)|lung(1)|pancreas(1)	5						CTGGAAGATGAAAGCTCCGAT	0.348		NA											13	13					0	0	0	0
CXorf21	80231	broad.mit.edu	37	X	30577959	30577959	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chrX:30577959G>T	uc004dcg.1	-	3	790	c.514C>A	c.(514-516)CAG>AAG	p.Q172K		NM_025159	NP_079435	Q9HAI6	CX021_HUMAN	hypothetical protein LOC80231	172										ovary(1)	1						TCACTGGGCTGAGTAGAAATG	0.428		NA											24	21					3.08e-08	3.75e-08	1	0
DMD	1756	broad.mit.edu	37	X	31496420	31496420	+	Missense_Mutation	SNP	C	C	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chrX:31496420C>G	uc004dda.1	-	59	8984	c.8740G>C	c.(8740-8742)GAG>CAG	p.E2914Q	DMD_uc004dcq.1_Missense_Mutation_p.E185Q|DMD_uc004dcr.1_Missense_Mutation_p.E454Q|DMD_uc004dcs.1_Missense_Mutation_p.E454Q|DMD_uc004dct.1_Missense_Mutation_p.E454Q|DMD_uc004dcu.1_Missense_Mutation_p.E454Q|DMD_uc004dcv.1_Missense_Mutation_p.E454Q|DMD_uc004dcw.2_Missense_Mutation_p.E1570Q|DMD_uc004dcx.2_Missense_Mutation_p.E1573Q|DMD_uc004dcz.2_Missense_Mutation_p.E2791Q|DMD_uc004dcy.1_Missense_Mutation_p.E2910Q|DMD_uc004ddb.1_Missense_Mutation_p.E2906Q	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	2914	Spectrin 21.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				TTTTCCCACTCAGTATTGACC	0.498		NA											18	23					0	0	0	0
DMD	1756	broad.mit.edu	37	X	32519917	32519917	+	Missense_Mutation	SNP	C	C	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chrX:32519917C>A	uc004dda.1	-	19	2579	c.2335G>T	c.(2335-2337)GAT>TAT	p.D779Y	DMD_uc004dcz.2_Missense_Mutation_p.D656Y|DMD_uc004dcy.1_Missense_Mutation_p.D775Y|DMD_uc004ddb.1_Missense_Mutation_p.D771Y|DMD_uc010ngo.1_Intron	NM_004006	NP_003997	P11532	DMD_HUMAN	dystrophin Dp427m isoform	779	Spectrin 4.				muscle filament sliding|peptide biosynthetic process	cell surface|costamere|cytoskeleton|cytosol|dystrophin-associated glycoprotein complex|sarcolemma	actin binding|dystroglycan binding|nitric-oxide synthase binding|protein binding|structural constituent of cytoskeleton|structural constituent of muscle|zinc ion binding			ovary(3)|pancreas(2)|large_intestine(1)	6		all_cancers(2;1.22e-16)|Acute lymphoblastic leukemia(2;4.65e-06)|all_hematologic(2;0.00108)|all_epithelial(3;0.00626)|all_neural(2;0.0189)|all_lung(315;0.182)|Glioma(3;0.203)				CTGCTGGCATCTTGCAGTTTT	0.413		NA											6	3					8.13e-05	9.14e-05	1	0
CXorf22	170063	broad.mit.edu	37	X	35993268	35993268	+	Silent	SNP	T	T	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chrX:35993268T>G	uc004ddj.2	+	14	2318	c.2259T>G	c.(2257-2259)CCT>CCG	p.P753P	CXorf22_uc010ngv.2_Intron	NM_152632	NP_689845	Q6ZTR5	CX022_HUMAN	hypothetical protein LOC170063	753										large_intestine(1)|lung(1)|ovary(1)	3						TTTCAGGGCCTTCTGTCCTTA	0.284		NA											23	27					0	0	0	0
ITIH5L	347365	broad.mit.edu	37	X	54785330	54785330	+	Missense_Mutation	SNP	T	T	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chrX:54785330T>C	uc004dtj.2	-	8	1207	c.1177A>G	c.(1177-1179)ATC>GTC	p.I393V		NM_198510	NP_940912	Q6UXX5	ITH5L_HUMAN	inter-alpha (globulin) inhibitor H5-like	393	VWFA.				hyaluronan metabolic process	extracellular region	serine-type endopeptidase inhibitor activity			lung(2)|skin(2)|ovary(1)|breast(1)	6						GTCAGGAAGATGATAAGAGGG	0.612		NA											11	6					0	0	0	0
KLF8	11279	broad.mit.edu	37	X	56310806	56310806	+	Missense_Mutation	SNP	A	A	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chrX:56310806A>T	uc004dur.2	+	6	1905	c.959A>T	c.(958-960)GAG>GTG	p.E320V	KLF8_uc011mop.1_3'UTR|KLF8_uc010nkh.2_RNA	NM_007250	NP_009181	O95600	KLF8_HUMAN	Kruppel-like factor 8 isoform 1	320	C2H2-type 2.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1						CGCTCAGATGAGCTCACTCGC	0.498		NA											4	6					0	0	0	0
TEX11	56159	broad.mit.edu	37	X	70026595	70026595	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chrX:70026595G>T	uc004dyl.2	-	10	859	c.697C>A	c.(697-699)CAG>AAG	p.Q233K	TEX11_uc004dym.2_Missense_Mutation_p.Q218K	NM_001003811	NP_001003811	Q8IYF3	TEX11_HUMAN	testis expressed sequence 11 isoform 1	233							protein binding			ovary(3)|breast(1)|skin(1)	5	Renal(35;0.156)					TTATTCTTCTGGGTTTCTACT	0.303		NA											3	5					0.00024832	0.000275081	1	0
MED12	9968	broad.mit.edu	37	X	70345277	70345277	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chrX:70345277G>T	uc004dyy.2	+	16	2502	c.2303G>T	c.(2302-2304)CGC>CTC	p.R768L	MED12_uc011mpq.1_Missense_Mutation_p.R768L|MED12_uc004dyz.2_Missense_Mutation_p.R768L|MED12_uc004dza.2_Missense_Mutation_p.R615L	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	768					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					GATGATGCCCGCCATGCCATC	0.532		NA											12	8					5.51e-06	6.36e-06	1	0
MED12	9968	broad.mit.edu	37	X	70353025	70353025	+	Missense_Mutation	SNP	A	A	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chrX:70353025A>G	uc004dyy.2	+	33	4779	c.4580A>G	c.(4579-4581)CAG>CGG	p.Q1527R	MED12_uc011mpq.1_Missense_Mutation_p.Q1527R|MED12_uc004dyz.2_Missense_Mutation_p.Q1527R|MED12_uc004dza.2_Missense_Mutation_p.Q1374R|MED12_uc010nla.2_Missense_Mutation_p.Q153R	NM_005120	NP_005111	Q93074	MED12_HUMAN	mediator complex subunit 12	1527					androgen receptor signaling pathway|negative regulation of Wnt receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter	mediator complex	ligand-dependent nuclear receptor transcription coactivator activity|protein C-terminus binding|protein domain specific binding|receptor activity|RNA polymerase II transcription cofactor activity|thyroid hormone receptor binding|vitamin D receptor binding			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4	Renal(35;0.156)					AAACCAAAGCAGCTTATGCAT	0.463		NA											30	34					0	0	0	0
MORF4L2	9643	broad.mit.edu	37	X	102931678	102931678	+	Missense_Mutation	SNP	T	T	A			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chrX:102931678T>A	uc004ekw.2	-	4	1510	c.278A>T	c.(277-279)GAA>GTA	p.E93V	MORF4L2_uc004ela.2_Missense_Mutation_p.E93V|MORF4L2_uc004ekx.2_Missense_Mutation_p.E93V|MORF4L2_uc004elb.2_Missense_Mutation_p.E93V|MORF4L2_uc004eky.2_Missense_Mutation_p.E93V|MORF4L2_uc010nos.2_Missense_Mutation_p.E93V|MORF4L2_uc004ekz.2_Missense_Mutation_p.E93V|MORF4L2_uc011mry.1_Missense_Mutation_p.E93V|MORF4L2_uc011mrz.1_Missense_Mutation_p.E93V|MORF4L2_uc004elc.2_Missense_Mutation_p.E93V|MORF4L2_uc004elf.2_Missense_Mutation_p.E93V|MORF4L2_uc004ele.2_Missense_Mutation_p.E93V|MORF4L2_uc011msa.1_Missense_Mutation_p.E93V|MORF4L2_uc011msb.1_Missense_Mutation_p.E93V|MORF4L2_uc011msc.1_Missense_Mutation_p.E93V|MORF4L2_uc011msd.1_Missense_Mutation_p.E93V|MORF4L2_uc004eld.2_Missense_Mutation_p.E93V	NM_012286	NP_036418	Q15014	MO4L2_HUMAN	mortality factor 4 like 2	93					chromatin modification|DNA repair|regulation of cell growth|transcription, DNA-dependent	nucleolus	protein binding				0						CTGAGGTGCTTCGCTGGTACT	0.542		NA											31	31					0	0	0	0
NRK	203447	broad.mit.edu	37	X	105168850	105168850	+	Missense_Mutation	SNP	G	G	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chrX:105168850G>T	uc004emd.2	+	19	3442	c.3139G>T	c.(3139-3141)GCA>TCA	p.A1047S	NRK_uc010npc.1_Missense_Mutation_p.A715S	NM_198465	NP_940867	Q7Z2Y5	NRK_HUMAN	Nik related kinase	1047							ATP binding|protein serine/threonine kinase activity|small GTPase regulator activity			breast(7)|ovary(3)|lung(2)|large_intestine(1)|central_nervous_system(1)	14						GGAAGAACATGCAGCCAATAT	0.517		NA								HNSCC(51;0.14)			9	10					3.1e-07	3.7e-07	1	0
ODZ1	10178	broad.mit.edu	37	X	123630881	123630881	+	Missense_Mutation	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chrX:123630881C>T	uc004euj.2	-	20	3744	c.3680G>A	c.(3679-3681)AGT>AAT	p.S1227N	ODZ1_uc011muj.1_Missense_Mutation_p.S1226N|ODZ1_uc010nqy.2_Missense_Mutation_p.S1227N	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1227	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						TTCCAAAATACTAACGGAGTT	0.398		NA											15	16					0	0	0	0
CDR1	1038	broad.mit.edu	37	X	139865920	139865920	+	Silent	SNP	C	C	T			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chrX:139865920C>T	uc004fbg.1	-	1	804	c.612G>A	c.(610-612)AAG>AAA	p.K204K	uc004fbf.1_RNA	NM_004065	NP_004056	P51861	CDR1_HUMAN	cerebellar degeneration-related protein 1,	204	5.|5 X 6 AA approximate repeats.										0	Acute lymphoblastic leukemia(192;7.65e-05)	Lung SC(4;0.051)				AAATCCAGGTCTTCCAGCCAA	0.448		NA											56	39					0	0	0	0
PGM1	5236	broad.mit.edu	37	1	64100692	64100693	+	Splice_Site	INS	-	-	G			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr1:64100692_64100693insG	uc001dbh.2	+	5	1086	c.873_splice	c.e5+2	p.G291_splice	PGM1_uc010ooy.1_Splice_Site_p.G94_splice|PGM1_uc010ooz.1_Splice_Site_p.G309_splice	NM_002633	NP_002624	P36871	PGM1_HUMAN	phosphoglucomutase 1						cellular calcium ion homeostasis|galactose catabolic process|glucose 1-phosphate metabolic process|glycogen biosynthetic process|glycogen catabolic process	cytosol	magnesium ion binding|phosphoglucomutase activity			ovary(2)|kidney(1)	3						GGAGATGGGGTGGGTATAAGTG	0.545		NA											18	84	---	---	---	---	NA	NA	NA	NA
IGSF22	283284	broad.mit.edu	37	11	18741425	18741425	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr11:18741425delG	uc009yht.2	-	7	724	c.534delC	c.(532-534)CCCfs	p.P178fs	IGSF22_uc001mpa.2_RNA	NM_173588	NP_775859	Q8N9C0	IGS22_HUMAN	immunoglobulin superfamily, member 22	178	Lys-rich.									ovary(4)|large_intestine(2)|kidney(1)	7						GCTTCTTCTTGGGAGCAGGGG	0.488		NA											53	109	---	---	---	---	NA	NA	NA	NA
MAML2	84441	broad.mit.edu	37	11	95713064	95713065	+	Frame_Shift_Del	DEL	GT	GT	-			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr11:95713064_95713065delGT	uc001pfw.1	-	5	3803_3804	c.2518_2519delAC	c.(2518-2520)ACCfs	p.T840fs		NM_032427	NP_115803	Q8IZL2	MAML2_HUMAN	mastermind-like 2	840					Notch signaling pathway|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear speck	transcription coactivator activity		CRTC1/MAML2(516)|CRTC3/MAML2(26)	salivary_gland(500)|lung(36)|thyroid(4)|breast(3)|skin(2)|ovary(1)	546		Acute lymphoblastic leukemia(157;2.63e-05)|all_hematologic(158;0.00837)				AGTTAAAATGGTGTGTGTTGAA	0.421		NA	T	MECT1|CRTC3	salivary gland mucoepidermoid								8	24	---	---	---	---	NA	NA	NA	NA
ACSM3	6296	broad.mit.edu	37	16	20793102	20793103	+	Frame_Shift_Ins	INS	-	-	C			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr16:20793102_20793103insC	uc002dhr.2	+	7	1199_1200	c.1012_1013insC	c.(1012-1014)ATAfs	p.I338fs	ACSM3_uc002dhq.2_Frame_Shift_Ins_p.I338fs|ACSM3_uc010vba.1_Frame_Shift_Ins_p.I367fs|ERI2_uc002dhs.2_Intron	NM_005622	NP_005613	Q53FZ2	ACSM3_HUMAN	SA hypertension-associated homolog isoform 1	338					regulation of blood pressure	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|metal ion binding			ovary(1)	1						ACAGAATGATATAACCAGGTAA	0.406		NA											21	51	---	---	---	---	NA	NA	NA	NA
TP53	7157	broad.mit.edu	37	17	7579514	7579514	+	Frame_Shift_Del	DEL	G	G	-	rs144386518		TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr17:7579514delG	uc002gim.2	-	4	367	c.173delC	c.(172-174)CCAfs	p.P58fs	TP53_uc002gig.1_Frame_Shift_Del_p.P58fs|TP53_uc002gih.2_Frame_Shift_Del_p.P58fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Frame_Shift_Del_p.P58fs|TP53_uc010cni.1_Frame_Shift_Del_p.P58fs|TP53_uc002gij.2_Frame_Shift_Del_p.P58fs|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Frame_Shift_Del_p.P19fs|TP53_uc010cnk.1_Frame_Shift_Del_p.P73fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	58	Interaction with HRMT1L2.		P -> T (in a sporadic cancer; somatic mutation).|P -> Q (in a sporadic cancer; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.P58L(1)|p.P58fs*65(1)|p.E51fs*59(1)|p.D48fs*55(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.D57_A76del20(1)|p.D57fs*86(1)|p.P58Q(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		ATCTGGACCTGGGTCTTCAGT	0.602		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			86	300	---	---	---	---	NA	NA	NA	NA
ABCA10	10349	broad.mit.edu	37	17	67148622	67148622	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr17:67148622delC	uc010dfa.1	-	36	5016	c.4137delG	c.(4135-4137)TGGfs	p.W1379fs	ABCA10_uc002jhz.2_5'Flank|ABCA10_uc010wqs.1_Frame_Shift_Del_p.W371fs|ABCA10_uc010wqt.1_RNA	NM_080282	NP_525021	Q8WWZ4	ABCAA_HUMAN	ATP-binding cassette, sub-family A, member 10	1379	ABC transporter 2.				transport	integral to membrane	ATP binding|ATPase activity			ovary(2)|central_nervous_system(1)|skin(1)	4	Breast(10;6.95e-12)					GAAGTATCTGCCTAAAGATAA	0.403		NA											12	63	---	---	---	---	NA	NA	NA	NA
MAP2	4133	broad.mit.edu	37	2	210559334	210559334	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr2:210559334delG	uc002vde.1	+	7	2688	c.2440delG	c.(2440-2442)GGCfs	p.G814fs	MAP2_uc002vdc.1_Frame_Shift_Del_p.G814fs|MAP2_uc002vdd.1_Intron|MAP2_uc002vdf.1_Intron|MAP2_uc002vdg.1_Intron|MAP2_uc002vdh.1_Intron|MAP2_uc002vdi.1_Frame_Shift_Del_p.G810fs	NM_002374	NP_002365	P11137	MAP2_HUMAN	microtubule-associated protein 2 isoform 1	814					central nervous system neuron development|dendrite morphogenesis|negative regulation of microtubule depolymerization	cytoplasm|microtubule|microtubule associated complex	beta-dystroglycan binding|calmodulin binding|structural molecule activity			ovary(9)|upper_aerodigestive_tract(2)|large_intestine(2)|pancreas(2)|central_nervous_system(1)|skin(1)	17		Hepatocellular(293;0.137)|Lung NSC(271;0.163)|Renal(323;0.202)		UCEC - Uterine corpus endometrioid carcinoma (47;6.64e-05)|Epithelial(149;3.12e-100)|all cancers(144;6.88e-91)|Lung(261;0.0624)|LUSC - Lung squamous cell carcinoma(261;0.0662)|STAD - Stomach adenocarcinoma(1183;0.18)	Estramustine(DB01196)	AGATCTGGCAGGCACAAGGTC	0.473		NA											30	120	---	---	---	---	NA	NA	NA	NA
SUN5	140732	broad.mit.edu	37	20	31590391	31590392	+	Splice_Site	DEL	AC	AC	-			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr20:31590391_31590392delAC	uc002wyi.2	-	3	304	c.211_splice	c.e3+1	p.S71_splice		NM_080675	NP_542406	Q8TC36	SUN5_HUMAN	sperm associated antigen 4-like						spermatogenesis					skin(1)	1						GTATATACGTACACACACATCC	0.554		NA											12	57	---	---	---	---	NA	NA	NA	NA
TACC3	10460	broad.mit.edu	37	4	1730308	1730308	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:1730308delC	uc003gdo.2	+	4	1287	c.1179delC	c.(1177-1179)GACfs	p.D393fs	TACC3_uc010ibz.2_Frame_Shift_Del_p.D393fs|TACC3_uc003gdp.2_Intron|TACC3_uc010ica.2_5'Flank	NM_006342	NP_006333	Q9Y6A5	TACC3_HUMAN	transforming, acidic coiled-coil containing	393						centrosome				ovary(1)|central_nervous_system(1)	2		Breast(71;0.212)|all_epithelial(65;0.241)	OV - Ovarian serous cystadenocarcinoma(23;0.00765)|Epithelial(3;0.0126)			CAGGAGAGGACCCCCCCATGC	0.612		NA											29	85	---	---	---	---	NA	NA	NA	NA
FSTL5	56884	broad.mit.edu	37	4	162376271	162376271	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr4:162376271delG	uc003iqh.2	-	15	2162	c.1726delC	c.(1726-1728)CTGfs	p.L576fs	FSTL5_uc003iqi.2_Frame_Shift_Del_p.L575fs|FSTL5_uc010iqv.2_Frame_Shift_Del_p.L566fs	NM_020116	NP_064501	Q8N475	FSTL5_HUMAN	follistatin-like 5 isoform a	576						extracellular region	calcium ion binding			ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)|skin(1)	8	all_hematologic(180;0.24)			COAD - Colon adenocarcinoma(41;0.179)		CCACTGGCCAGGGTAATTACC	0.403		NA											9	33	---	---	---	---	NA	NA	NA	NA
NSD1	64324	broad.mit.edu	37	5	176638682	176638682	+	Frame_Shift_Del	DEL	G	G	-			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr5:176638682delG	uc003mfr.3	+	5	3420	c.3282delG	c.(3280-3282)ATGfs	p.M1094fs	NSD1_uc003mft.3_Frame_Shift_Del_p.M825fs|NSD1_uc003mfs.1_Frame_Shift_Del_p.M991fs|NSD1_uc011dfx.1_Frame_Shift_Del_p.M742fs	NM_022455	NP_071900	Q96L73	NSD1_HUMAN	nuclear receptor binding SET domain protein 1	1094					negative regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	chromosome|nucleus	androgen receptor binding|chromatin binding|estrogen receptor binding|histone methyltransferase activity (H3-K36 specific)|histone methyltransferase activity (H4-K20 specific)|ligand-dependent nuclear receptor binding|retinoid X receptor binding|thyroid hormone receptor binding|transcription corepressor activity|zinc ion binding			ovary(2)|kidney(1)	3	all_cancers(89;1.57e-05)|Renal(175;0.000269)|Lung NSC(126;0.00111)|all_lung(126;0.002)	all_neural(177;0.00409)|Medulloblastoma(196;0.00498)|all_hematologic(541;0.21)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)|Epithelial(233;0.198)	Kidney(146;0.235)		TTCAGATAATGGGCCACTTAA	0.448		NA	T	NUP98	AML		Sotos Syndrome		Beckwith-Wiedemann_syndrome|Sotos_syndrome|Weaver_syndrome	HNSCC(47;0.14)			24	49	---	---	---	---	NA	NA	NA	NA
SRRT	51593	broad.mit.edu	37	7	100484691	100484691	+	Frame_Shift_Del	DEL	C	C	-			TCGA-F7-7848-01A-11D-2129-08	TCGA-F7-7848-10A-01D-2129-08	 	 	 	 	 	 	 	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	ba8a3e47-ee55-4c88-b29f-6d161ffae1d0	deac6477-626d-42a3-857d-c35b3cc86d2d	g.chr7:100484691delC	uc003uwy.2	+	16	2113	c.1845delC	c.(1843-1845)TACfs	p.Y615fs	SRRT_uc010lhl.1_Frame_Shift_Del_p.Y614fs|SRRT_uc003uxa.2_Frame_Shift_Del_p.Y614fs|SRRT_uc003uwz.2_Frame_Shift_Del_p.Y615fs	NM_015908	NP_056992	Q9BXP5	SRRT_HUMAN	arsenate resistance protein 2 isoform a	615					cell proliferation|primary miRNA processing|response to arsenic-containing substance	cytoplasm|nucleoplasm	protein binding			ovary(2)	2						TCCTCCTTTACCTGCGCATCG	0.602		NA											65	193	---	---	---	---	NA	NA	NA	NA
