Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	validation_method	t_ref_count	validation_status	validation_tumor_sample	t_alt_count	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
KLRC1	3821	broad.mit.edu	37	12	10603138	10603138	+	Silent	SNP	C	T	T			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr12:10603138C>T	uc001qyl.3	-	2	442	c.228G>A	c.(226-228)ctG>ctA	p.L76L	KLRC1_uc009zhm.2_Silent_p.L76L|KLRC1_uc001qym.3_Silent_p.L76L|KLRC1_uc001qyn.3_Silent_p.L76L|KLRC1_uc001qyo.3_Silent_p.L76L	NM_002259	NP_998823	P26715	NKG2A_HUMAN	Homo sapiens killer cell lectin-like receptor subfamily C, member 1 (KLRC1), transcript variant 1, mRNA.	76					cell surface receptor linked signaling pathway|regulation of immune response	integral to plasma membrane	sugar binding|transmembrane receptor activity			NS(1)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(2)|lung(8)|skin(1)	16						AGATAATTCCCAGGATCCCAA	0.418000														82			55		0	0	0.014410	0	0
DNAH17	8632	broad.mit.edu	37	17	76511015	76511015	+	Silent	SNP	C	T	T			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr17:76511015C>T	uc010dhp.2	-	25	4079	c.3954G>A	c.(3952-3954)aaG>aaA	p.K1318K		NM_173628	NP_775899			Homo sapiens dynein, axonemal, heavy chain 17 (DNAH17), mRNA.									p.R1318S(1)		NS(2)|breast(7)|central_nervous_system(5)|cervix(1)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(13)|large_intestine(8)|lung(37)|ovary(8)|prostate(7)|skin(4)|stomach(2)|upper_aerodigestive_tract(3)|urinary_tract(3)	116			BRCA - Breast invasive adenocarcinoma(99;0.00294)|OV - Ovarian serous cystadenocarcinoma(97;0.0656)			ACCTCATGTCCTTGGCAAACT	0.493000														63			64		0	0	0.014410	0	0
PLA2G4F	255189	broad.mit.edu	37	15	42436655	42436655	+	Silent	SNP	G	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr15:42436655G>A	uc001zoz.3	-	16	2060	c.1968C>T	c.(1966-1968)gcC>gcT	p.A656A	PLA2G4F_uc010bcq.3_Missense_Mutation_p.P9L|PLA2G4F_uc001zoy.3_Silent_p.A288A|PLA2G4F_uc001zpa.3_Silent_p.A407A|PLA2G4F_uc010bcr.3_Silent_p.A407A|PLA2G4F_uc010bcs.3_Silent_p.A443A	NM_213600	NP_998765	Q68DD2	PA24F_HUMAN	Homo sapiens phospholipase A2, group IVF (PLA2G4F), transcript variant 1, mRNA.	656	PLA2c.				phospholipid catabolic process	cytosol|lysosomal membrane	metal ion binding|phospholipase A2 activity			breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(2)|kidney(3)|large_intestine(3)|liver(1)|lung(12)|ovary(4)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	32		all_cancers(109;4.82e-12)|all_epithelial(112;5.64e-11)|Lung NSC(122;2.17e-07)|all_lung(180;8.79e-07)|Melanoma(134;0.091)		GBM - Glioblastoma multiforme(94;8.97e-07)		CACCTTTCCAGGCCACGAACT	0.612000														32			25		0	0	0.009535	0	0
ODZ2	57451	broad.mit.edu	37	5	167631399	167631399	+	Silent	SNP	G	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr5:167631399G>A	uc010jjd.3	+	18	3570	c.3570G>A	c.(3568-3570)ggG>ggA	p.G1190G	ODZ2_uc003lzr.4_Silent_p.G967G|ODZ2_uc003lzt.4_Silent_p.G563G|ODZ2_uc010jje.3_Silent_p.G461G	NM_001122679	NP_001116151			Homo sapiens odz, odd Oz/ten-m homolog 2 (Drosophila) (ODZ2), mRNA.											NS(1)|autonomic_ganglia(1)|breast(5)|central_nervous_system(4)|cervix(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(3)|kidney(3)|large_intestine(29)|lung(45)|ovary(8)|pancreas(1)|prostate(3)|skin(2)|stomach(2)|urinary_tract(2)	122	Renal(175;0.00124)|Lung NSC(126;0.136)|all_lung(126;0.242)	Medulloblastoma(196;0.0241)|all_neural(177;0.026)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0444)|OV - Ovarian serous cystadenocarcinoma(192;0.0694)|Epithelial(171;0.124)		AAGGCACTGGGGAAAACCAGT	0.587000														18			11		0	0	0.001855	0	0
HR	55806	broad.mit.edu	37	8	21984639	21984639	+	Missense_Mutation	SNP	G	T	T			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr8:21984639G>T	uc003xas.3	-	2	1981	c.1316C>A	c.(1315-1317)gCa>gAa	p.A439E	HR_uc003xat.3_Missense_Mutation_p.A439E	NM_005144	NP_005135	O43593	HAIR_HUMAN	Homo sapiens hairless homolog (mouse) (HR), transcript variant 1, mRNA.	439							DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	27		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		CCCCTGTTCTGCAGTGCCTGG	0.652000														84			185		3.57236e-102	4.18828e-102	0.014410	1	0
ADAM20	8748	broad.mit.edu	37	14	70990374	70990374	+	Silent	SNP	A	G	G			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr14:70990374A>G	uc021rvs.1	-	0	1251	c.1251T>C	c.(1249-1251)caT>caC	p.H417H	ADAM20_uc001xme.3_Silent_p.H417H	NM_003814	NP_003805	O43506	ADA20_HUMAN	Homo sapiens ADAM metallopeptidase domain 20 (ADAM20), mRNA.	367	Disintegrin.				proteolysis|single fertilization	integral to membrane	metalloendopeptidase activity|zinc ion binding			autonomic_ganglia(1)|breast(2)|endometrium(2)|kidney(1)|large_intestine(3)|lung(15)|prostate(1)|skin(2)	27			KIRC - Kidney renal clear cell carcinoma(12;0.133)|Kidney(31;0.188)	all cancers(60;0.00294)|BRCA - Breast invasive adenocarcinoma(234;0.00668)|OV - Ovarian serous cystadenocarcinoma(108;0.0344)		TTCTATAGGCATGCATTATGC	0.433000														71			44		0	0	0.014410	0	0
NCAM1	4684	broad.mit.edu	37	11	113075075	113075075	+	Missense_Mutation	SNP	C	G	G			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr11:113075075C>G	uc021qqp.1	+	2	561	c.189C>G	c.(187-189)aaC>aaG	p.N63K	NCAM1_uc001pno.3_5'UTR|NCAM1_uc001pnp.3_Missense_Mutation_p.N63K|NCAM1_uc021qqo.1_Missense_Mutation_p.N63K|NCAM1_uc001pnq.3_Missense_Mutation_p.N63K|NCAM1_uc001pnr.3_Missense_Mutation_p.N63K	NM_001242607	NP_001229536	P13591	NCAM1_HUMAN	Homo sapiens neural cell adhesion molecule 1 (NCAM1), transcript variant 5, mRNA.	65	Ig-like C2-type 1.				axon guidance|interferon-gamma-mediated signaling pathway	Golgi membrane|anchored to membrane|extracellular region|integral to membrane				breast(1)|endometrium(3)|kidney(1)|large_intestine(11)|lung(27)|ovary(3)|prostate(2)|upper_aerodigestive_tract(1)	49		all_cancers(61;5.82e-19)|all_epithelial(67;6.87e-12)|Melanoma(852;1.99e-05)|all_hematologic(158;3.66e-05)|Acute lymphoblastic leukemia(157;0.00119)|Breast(348;0.0109)|all_neural(223;0.0299)|Medulloblastoma(222;0.0458)|Renal(330;0.198)|Prostate(24;0.207)		BRCA - Breast invasive adenocarcinoma(274;1.78e-05)|Epithelial(105;0.000114)|all cancers(92;0.000467)|OV - Ovarian serous cystadenocarcinoma(223;0.212)		TCACCCCAAACCAGCAGCGGA	0.478000														13			17		0	0	0.006122	0	0
CAPS	828	broad.mit.edu	37	19	5915048	5915048	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr19:5915048G>A	uc002mdt.3	+	3	509	c.359G>A	c.(358-360)gGg>gAg	p.G120E	CAPS_uc002mdu.3_Missense_Mutation_p.G120E	NM_004058	NP_004049	Q13938	CAYP1_HUMAN	Homo sapiens calcyphosine (CAPS), transcript variant 1, mRNA.	120	EF-hand 3.				intracellular signal transduction	cytoplasm	calcium ion binding			cervix(2)|haematopoietic_and_lymphoid_tissue(1)|lung(1)	4						GACCTCCGCGGGGTGTACAGT	0.677000														95			56		0	0	0.014410	0	0
OR11H12	440153	broad.mit.edu	37	14	19378122	19378122	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr14:19378122C>T	uc010tkp.2	+	0	529	c.529C>T	c.(529-531)Ctc>Ttc	p.L177F		NM_001013354	NP_001013372	B2RN74	O11HC_HUMAN	Homo sapiens olfactory receptor, family 11, subfamily H, member 12 (OR11H12), mRNA.	177					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			NS(2)|endometrium(1)|kidney(1)|large_intestine(1)|lung(13)|ovary(2)|skin(1)|upper_aerodigestive_tract(1)	22	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		CCCCATTGTTCTCATCTCTCA	0.478000														261			17		0	0	0.008740	0	0
SIPA1L2	57568	broad.mit.edu	37	1	232581393	232581393	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr1:232581393T>C	uc001hvg.3	-	8	3393	c.3235A>G	c.(3235-3237)Aga>Gga	p.R1079G	SIPA1L2_uc001hvf.3_Missense_Mutation_p.R153G	NM_020808	NP_065859	Q9P2F8	SI1L2_HUMAN	Homo sapiens signal-induced proliferation-associated 1 like 2 (SIPA1L2), mRNA.	1079					regulation of small GTPase mediated signal transduction	intracellular	GTPase activator activity			NS(1)|breast(5)|central_nervous_system(2)|endometrium(15)|haematopoietic_and_lymphoid_tissue(1)|kidney(7)|large_intestine(13)|lung(49)|ovary(2)|pancreas(1)|prostate(2)|skin(3)|upper_aerodigestive_tract(2)	103		all_cancers(173;0.00605)|Prostate(94;0.128)|all_epithelial(177;0.186)				GGGGAAGCTCTAGAGAGGGGC	0.657000														70			23		0	0	0.002780	0	0
WNT10B	7480	broad.mit.edu	37	12	49360258	49360258	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr12:49360258C>T	uc001rss.3	-	4	1234	c.790G>A	c.(790-792)Gcg>Acg	p.A264T	WNT10B_uc001rst.3_3'UTR	NM_003394	NP_003385	O00744	WN10B_HUMAN	Homo sapiens wingless-type MMTV integration site family, member 10B (WNT10B), mRNA.	264					Wnt receptor signaling pathway, calcium modulating pathway|axis specification|bone trabecula formation|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|chondrocyte differentiation|female gonad development|hemopoietic stem cell proliferation|midbrain-hindbrain boundary development|myoblast cell differentiation involved in skeletal muscle regeneration|negative regulation of epithelial cell proliferation|negative regulation of fat cell differentiation|neuron differentiation|positive regulation of anagen|positive regulation of apoptosis|positive regulation of bone mineralization|positive regulation of cell proliferation|positive regulation of epithelial cell differentiation|positive regulation of osteoblast differentiation|protein stabilization|regulation of skeletal muscle tissue development|skeletal muscle fiber development|smoothened signaling pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	G-protein-coupled receptor binding|signal transducer activity			central_nervous_system(1)|large_intestine(5)|lung(12)|prostate(1)|skin(4)	23						TCTGGGGCCGCCCTCCAGCAT	0.592000														23			30		0	0	0.004878	0	0
PCNT	5116	broad.mit.edu	37	21	47805830	47805830	+	Silent	SNP	G	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr21:47805830G>A	uc002zji.4	+	16	3503	c.3396G>A	c.(3394-3396)cgG>cgA	p.R1132R	PCNT_uc002zjj.3_Silent_p.R1014R	NM_006031	NP_006022	O95613	PCNT_HUMAN	Homo sapiens pericentrin (PCNT), mRNA.	1132					G2/M transition of mitotic cell cycle|cilium assembly	cytosol|microtubule	calmodulin binding			NS(1)|breast(5)|central_nervous_system(2)|cervix(1)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(5)|large_intestine(15)|liver(2)|lung(41)|ovary(5)|pancreas(3)|prostate(3)|skin(5)|upper_aerodigestive_tract(2)|urinary_tract(2)	104	Breast(49;0.112)					GGCGGGAGCGGGAGAACCGGG	0.572000														78			55		0	0	0.014410	0	0
NUP107	57122	broad.mit.edu	37	12	69120309	69120309	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr12:69120309C>T	uc001suf.3	+	18	1722	c.1607C>T	c.(1606-1608)tCc>tTc	p.S536F	NUP107_uc001sug.3_Missense_Mutation_p.S383F|NUP107_uc010stj.2_Missense_Mutation_p.S507F	NM_020401	NP_065134	P57740	NU107_HUMAN	Homo sapiens nucleoporin 107kDa (NUP107), mRNA.	536					carbohydrate metabolic process|glucose transport|mRNA export from nucleus|mitotic prometaphase|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	Nup107-160 complex|condensed chromosome kinetochore|cytosol	nucleocytoplasmic transporter activity|protein binding		NUP107/LGR5(2)	breast(3)|endometrium(4)|kidney(4)|large_intestine(12)|lung(11)|prostate(1)|skin(2)|urinary_tract(2)	39	Breast(13;6.25e-06)		Lung(24;0.000131)|LUAD - Lung adenocarcinoma(15;0.00107)|STAD - Stomach adenocarcinoma(21;0.00694)			AAATGGCTTTCCAAAAGCAGA	0.348000														41			23		0	0	0.004656	0	0
DOCK2	1794	broad.mit.edu	37	5	169101380	169101380	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr5:169101380G>A	uc003maf.3	+	5	481	c.401G>A	c.(400-402)gGa>gAa	p.G134E	DOCK2_uc011der.2_Non-coding_Transcript	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	Homo sapiens dedicator of cytokinesis 2 (DOCK2), mRNA.	134					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	GTP binding|GTPase binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding|electron carrier activity|heme binding			NS(2)|breast(5)|cervix(1)|endometrium(10)|haematopoietic_and_lymphoid_tissue(1)|kidney(9)|large_intestine(42)|liver(2)|lung(63)|ovary(5)|pancreas(3)|prostate(7)|skin(5)|stomach(2)|upper_aerodigestive_tract(3)	160	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTTCTCTCAGGAACCTTACCC	0.478000														61			42		0	0	0.014410	0	0
FAT4	79633	broad.mit.edu	37	4	126328119	126328119	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr4:126328119G>A	uc003ifj.4	+	2	5392	c.5392G>A	c.(5392-5394)Gca>Aca	p.A1798T	FAT4_uc011cgp.2_Missense_Mutation_p.A96T	NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	Homo sapiens FAT tumor suppressor homolog 4 (Drosophila) (FAT4), mRNA.	1798	Cadherin 17.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						AGATCTGATAGCAACCAGGCG	0.458000														157			4		0	0	0.000602	0	0
TMED8	283578	broad.mit.edu	37	14	77809738	77809738	+	Silent	SNP	G	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr14:77809738G>A	uc001xto.1	-	4	543	c.543C>T	c.(541-543)agC>agT	p.S181S	TMED8_uc001xtn.1_Silent_p.S25S	NM_213601	NP_998766	Q6PL24	TMED8_HUMAN	Homo sapiens transmembrane emp24 protein transport domain containing 8 (TMED8), mRNA.	181	GOLD.				transport	integral to membrane				breast(2)|central_nervous_system(1)|endometrium(4)|kidney(1)|large_intestine(3)|lung(4)	15			Kidney(204;0.164)	BRCA - Breast invasive adenocarcinoma(234;0.0281)		CCACCAGACGGCTGTTCTTCT	0.542000														14			21		0	0	0.002780	0	0
ATF1	466	broad.mit.edu	37	12	51208211	51208211	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr12:51208211A>T	uc001rww.4	+	5	968	c.660A>T	c.(658-660)ttA>ttT	p.L220F	ATF1_uc010smu.2_Missense_Mutation_p.L85F	NM_005171	NP_005162	P18846	ATF1_HUMAN	Homo sapiens activating transcription factor 1 (ATF1), mRNA.	220					MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|Toll signaling pathway|innate immune response|nerve growth factor receptor signaling pathway|stress-activated MAPK cascade|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway				EWSR1/ATF1(347)|FUS/ATF1(4)	breast(1)|large_intestine(1)|ovary(2)	4						AAATAAGGTTAATGAAAAACA	0.388000			T	"""EWSR1, FUS"""	"""malignant melanoma of soft parts , angiomatoid fibrous histiocytoma """									29			24		0	0	0.003271	0	0
ZNF92	168374	broad.mit.edu	37	7	64863705	64863705	+	Silent	SNP	A	G	G			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr7:64863705A>G	uc003ttz.3	+	3	821	c.678A>G	c.(676-678)gaA>gaG	p.E226E	ZNF92_uc003tua.3_Silent_p.E157E|ZNF92_uc010kzu.3_Silent_p.E194E|ZNF92_uc003tub.3_Silent_p.E150E|ZNF92_uc022afd.1_5'Flank	NM_152626	NP_009070	Q03936	ZNF92_HUMAN	Homo sapiens zinc finger protein 92 (ZNF92), transcript variant 2, mRNA.	226						nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			breast(2)|endometrium(1)|large_intestine(3)|lung(4)|pancreas(1)|skin(1)|stomach(1)	13		Lung NSC(55;0.159)				ATACTGGAGAAAAACCCTACA	0.338000														96			3		0	0	0.009096	0	0
KRTAP4-6	81871	broad.mit.edu	37	17	39296563	39296563	+	Silent	SNP	G	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr17:39296563G>A	uc010cxk.2	-	0	177	c.177C>T	c.(175-177)acC>acT	p.T59T		NM_030976	NP_112238	Q9BYQ5	KRA46_HUMAN	Homo sapiens keratin associated protein 4-6 (KRTAP4-6), mRNA.	59	29 X 5 AA repeats of C-C-[IRQVEL]-[SPTR]- [STVQRCP].					keratin filament				endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|lung(1)|prostate(1)|urinary_tract(1)	9						gacggcagcAGGTGGGCTGGC	0.667000														150			5		0	0	0.001168	0	0
SLC45A4	57210	broad.mit.edu	37	8	142229073	142229073	+	Silent	SNP	G	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr8:142229073G>A	uc003ywd.1	-	3	821	c.513C>T	c.(511-513)ttC>ttT	p.F171F	SLC45A4_uc003ywc.1_Silent_p.F171F|SLC45A4_uc010meq.1_Silent_p.F169F	NM_001080431	NP_001073900	Q5BKX6	S45A4_HUMAN	Homo sapiens solute carrier family 45, member 4 (SLC45A4), mRNA.	222					transport	integral to membrane				breast(1)|central_nervous_system(1)|endometrium(5)|kidney(2)|large_intestine(6)|lung(9)|ovary(3)|prostate(2)|skin(1)|upper_aerodigestive_tract(1)	31	all_cancers(97;1.52e-15)|all_epithelial(106;2.92e-14)|Lung NSC(106;1.23e-05)|all_lung(105;1.75e-05)|Ovarian(258;0.01)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0493)			AGCTGCCCAGGAAGGTCTGGG	0.662000														80			30		0	0	0.003755	0	0
CDC27	996	broad.mit.edu	37	17	45234749	45234749	+	Splice_Site	SNP	A	C	C	rs148497428		TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr17:45234749A>C	uc002ile.4	-	6	603	c.476_splice	c.e6-1	p.G159_splice	CDC27_uc002ild.4_Splice_Site_p.G159_splice|CDC27_uc002ilf.4_Splice_Site_p.G159_splice|CDC27_uc010wkp.2_Splice_Site_p.G98_splice|CDC27_uc010wkq.1_Splice_Site	NM_001114091	NP_001107563	P30260	CDC27_HUMAN	Homo sapiens cell division cycle 27 homolog (S. cerevisiae) (CDC27), transcript variant 1, mRNA.	159					anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell proliferation|mitotic cell cycle spindle assembly checkpoint|mitotic metaphase/anaphase transition|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|centrosome|cytosol|nucleoplasm|spindle microtubule	protein phosphatase binding	p.G159G(3)		NS(1)|breast(5)|central_nervous_system(3)|cervix(1)|endometrium(2)|kidney(17)|large_intestine(18)|lung(11)|ovary(5)|pancreas(1)|prostate(19)|skin(5)|upper_aerodigestive_tract(2)	90						CTGGCTTTTCACCTGTGAAGA	0.358000														45			6		0	0	0.003080	0	0
MUC4	4585	broad.mit.edu	37	3	195505835	195505835	+	Missense_Mutation	SNP	C	T	T	rs58500707	by1000genomes	TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr3:195505835C>T	uc021xjp.1	-	1	12772	c.12616G>A	c.(12616-12618)Gcc>Acc	p.A4206T	MUC4_uc003fva.3_5'Flank|MUC4_uc003fvb.3_5'Flank|MUC4_uc003fvc.3_5'Flank|MUC4_uc003fvd.3_5'Flank|MUC4_uc003fve.3_5'Flank|MUC4_uc010hzr.3_5'Flank|MUC4_uc021xjm.1_Intron|MUC4_uc021xjn.1_Intron|MUC4_uc021xjo.1_Intron|MUC4_uc021xjg.1_Intron|MUC4_uc021xjh.1_Intron|MUC4_uc021xji.1_Intron|MUC4_uc021xjj.1_Intron|MUC4_uc021xjk.1_Intron|MUC4_uc021xjl.1_Intron|MUC4_uc003fvo.3_Intron|MUC4_uc003fvp.3_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	Homo sapiens mucin 4, cell surface associated (MUC4), transcript variant 1, mRNA.	969					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.A4206T(3)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		AGAGGGGTGGCGTGACCTGTG	0.597000														4			3		0	0	0.004672	0	0
GPR124	25960	broad.mit.edu	37	8	37693253	37693253	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr8:37693253G>A	uc003xkj.3	+	12	2401	c.2015G>A	c.(2014-2016)cGt>cAt	p.R672H	GPR124_uc010lvy.3_Intron	NM_032777	NP_116166	Q96PE1	GP124_HUMAN	Homo sapiens G protein-coupled receptor 124 (GPR124), mRNA.	672					central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			central_nervous_system(1)|endometrium(5)|kidney(3)|large_intestine(4)|lung(16)|ovary(4)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	37			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			GGCAAGAGGCGTGGCGTGGCC	0.647000														101			31		0	0	0.013726	0	0
TMEM200A	114801	broad.mit.edu	37	6	130762051	130762051	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr6:130762051G>A	uc003qcb.3	+	1	2862	c.484G>A	c.(484-486)Gat>Aat	p.D162N	TMEM200A_uc003qca.3_Missense_Mutation_p.D162N|TMEM200A_uc010kfh.3_Missense_Mutation_p.D162N|TMEM200A_uc010kfi.3_Missense_Mutation_p.D162N|TMEM200A_uc021zfg.1_Missense_Mutation_p.D162N	NM_052913	NP_443145	Q86VY9	T200A_HUMAN	Homo sapiens transmembrane protein 200A (TMEM200A), mRNA.	162						integral to membrane		p.R161S(1)		NS(1)|endometrium(4)|kidney(1)|large_intestine(5)|lung(30)|ovary(1)|prostate(4)|skin(3)|upper_aerodigestive_tract(2)|urinary_tract(1)	52				GBM - Glioblastoma multiforme(226;0.0139)|OV - Ovarian serous cystadenocarcinoma(155;0.12)		ACACATGAGGGATATCTATTC	0.408000														46			28		0	0	0.004289	0	0
PTBP2	58155	broad.mit.edu	37	1	97236329	97236330	+	Missense_Mutation	DNP	AC	TT	TT			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr1:97236329_97236330AC>TT	uc001drq.3	+	4	600_601	c.354_355AC>TT	c.(352-357)acacct>acTTct	p.P119S	PTBP2_uc001drn.2_Missense_Mutation_p.P119S|PTBP2_uc001dro.2_Missense_Mutation_p.P119S|PTBP2_uc010otz.1_Missense_Mutation_p.P130S|PTBP2_uc001drp.2_Non-coding_Transcript|PTBP2_uc009wdw.2_Missense_Mutation_p.P67S|PTBP2_uc001drr.3_Missense_Mutation_p.P119S|PTBP2_uc001dru.3_Non-coding_Transcript|PTBP2_uc001drm.2_Missense_Mutation_p.P119S	NM_021190	NP_067013	Q9UKA9	PTBP2_HUMAN	Homo sapiens polypyrimidine tract binding protein 2 (PTBP2), mRNA.	119	RRM 1.						nucleotide binding			central_nervous_system(1)|endometrium(3)|kidney(1)|large_intestine(5)|lung(15)|skin(1)	26		all_epithelial(167;2.95e-05)|all_lung(203;0.000396)|Lung NSC(277;0.00171)		all cancers(265;0.0582)|Epithelial(280;0.0716)|Colorectal(170;0.0879)|KIRC - Kidney renal clear cell carcinoma(1967;0.202)		CTGCTGTGACACCTCATCTTCG	0.327000														43			31		0	0	0.004672	0	0
IL22RA1	58985	broad.mit.edu	37	1	24454678	24454678	+	Missense_Mutation	SNP	C	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr1:24454678C>A	uc001biq.2	-	4	826	c.623G>T	c.(622-624)tGg>tTg	p.W208L	IL22RA1_uc010oeg.1_Missense_Mutation_p.W100L|IL22RA1_uc009vrb.2_Missense_Mutation_p.W72L|IL22RA1_uc010oeh.2_Missense_Mutation_p.W208L	NM_021258	NP_067081	Q8N6P7	I22R1_HUMAN	Homo sapiens interleukin 22 receptor, alpha 1 (IL22RA1), mRNA.	208	Fibronectin type-III 2.					integral to membrane	interferon receptor activity			breast(2)|endometrium(2)|large_intestine(4)|lung(7)|skin(2)|stomach(1)|upper_aerodigestive_tract(1)	19		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000992)|all_lung(284;0.00138)|Ovarian(437;0.00348)|Breast(348;0.0126)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|OV - Ovarian serous cystadenocarcinoma(117;3.84e-24)|Colorectal(126;6.43e-08)|COAD - Colon adenocarcinoma(152;3.51e-06)|GBM - Glioblastoma multiforme(114;5.06e-05)|BRCA - Breast invasive adenocarcinoma(304;0.00104)|KIRC - Kidney renal clear cell carcinoma(1967;0.00371)|STAD - Stomach adenocarcinoma(196;0.00911)|READ - Rectum adenocarcinoma(331;0.0655)|Lung(427;0.148)		CTCCTTGGCCCAGGTGGGAAC	0.557000														80			23		4.7796e-09	5.35736e-09	0.004656	1	0
CASR	846	broad.mit.edu	37	3	122003268	122003268	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr3:122003268C>T	uc003eew.4	+	6	2935	c.2497C>T	c.(2497-2499)Cca>Tca	p.P833S	CASR_uc003eev.4_Missense_Mutation_p.P823S	NM_001178065	NP_001171536	P41180	CASR_HUMAN	Homo sapiens calcium-sensing receptor (CASR), transcript variant 1, mRNA.	823					anatomical structure morphogenesis|calcium ion import|cellular calcium ion homeostasis|chemosensory behavior|detection of calcium ion|ossification	integral to plasma membrane	G-protein coupled receptor activity|phosphatidylinositol phospholipase C activity			NS(1)|breast(2)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(13)|lung(45)|ovary(4)|prostate(3)|skin(5)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	84				GBM - Glioblastoma multiforme(114;0.226)	Cinacalcet(DB01012)	CTCCTTCATTCCAGCCTATGC	0.512000														62			37		0	0	0.014410	0	0
C14orf28	122525	broad.mit.edu	37	14	45369816	45369816	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr14:45369816G>C	uc001wvo.3	+	1	444	c.178G>C	c.(178-180)Gat>Cat	p.D60H	C14orf28_uc001wvp.1_Missense_Mutation_p.D60H	NM_001017923	NP_001017923	Q4W4Y0	CN028_HUMAN	Homo sapiens chromosome 14 open reading frame 28 (C14orf28), mRNA.	60										endometrium(1)|large_intestine(3)|liver(1)|lung(4)|ovary(2)	11						CTGCACCATAGATGGATTCTT	0.378000														26			30		0	0	0.003755	0	0
CRY2	1408	broad.mit.edu	37	11	45891312	45891312	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr11:45891312G>A	uc010rgn.2	+	6	1223	c.1201G>A	c.(1201-1203)Gtg>Atg	p.V401M	CRY2_uc009ykw.3_Missense_Mutation_p.V319M|CRY2_uc010rgo.2_Missense_Mutation_p.V123M	NM_021117	NP_066940	Q49AN0	CRY2_HUMAN	Homo sapiens cryptochrome 2 (photolyase-like) (CRY2), transcript variant 1, mRNA.	380	FAD-binding.|Required for inhibition of CLOCK-ARNTL- mediated transcription (By similarity).				DNA repair|protein-chromophore linkage|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA photolyase activity|blue light photoreceptor activity|damaged DNA binding|nucleotide binding|protein binding|single-stranded DNA binding			NS(1)|central_nervous_system(1)|endometrium(2)|kidney(2)|large_intestine(1)|lung(6)|prostate(2)	15						CCGGCATGCCGTGGCCTGCTT	0.642000														28			3		0	0	0.009096	0	0
KIF14	9928	broad.mit.edu	37	1	200574423	200574423	+	Missense_Mutation	SNP	C	G	G	rs144936292	byFrequency	TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr1:200574423C>G	uc010ppk.1	-	7	2173	c.1734G>C	c.(1732-1734)atG>atC	p.M578I	KIF14_uc010ppj.1_Missense_Mutation_p.M87I	NM_014875	NP_055690	Q15058	KIF14_HUMAN	Homo sapiens kinesin family member 14 (KIF14), mRNA.	578	Kinesin-motor.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			NS(1)|breast(5)|central_nervous_system(2)|endometrium(8)|kidney(8)|large_intestine(15)|lung(13)|ovary(3)|prostate(2)|skin(3)|urinary_tract(1)	61						TGGTCTGGGTCATCACCAGGG	0.388000														94			3		0	0	0.004672	0	0
ANKRD36B	57730	broad.mit.edu	37	2	98165937	98165937	+	Silent	SNP	T	C	C			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr2:98165937T>C	uc010yvc.1	-	19	1702	c.1422A>G	c.(1420-1422)gaA>gaG	p.E474E	ANKRD36B_uc010yve.1_Non-coding_Transcript	NM_025190	NP_079466	Q8N2N9	AN36B_HUMAN	Homo sapiens ankyrin repeat domain 36B (ANKRD36B), mRNA.	474																	AAACAGAATCTTCCTTGACAC	0.294000														8			7		0	0	0.008291	0	0
MDGA1	266727	broad.mit.edu	37	6	37619953	37619953	+	Silent	SNP	C	T	T			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr6:37619953C>T	uc003onu.1	-	6	2325	c.1146G>A	c.(1144-1146)aaG>aaA	p.K382K	MDGA1_uc003onw.3_Non-coding_Transcript	NM_153487	NP_705691	Q8NFP4	MDGA1_HUMAN	Homo sapiens MAM domain containing glycosylphosphatidylinositol anchor 1 (MDGA1), mRNA.	382	Ig-like 4.				brain development|neuron migration|spinal cord association neuron differentiation	anchored to plasma membrane				central_nervous_system(2)|endometrium(6)|kidney(3)|large_intestine(12)|lung(11)|prostate(1)|skin(2)|urinary_tract(1)	38						CCAGCAGCCGCTTGGACATGC	0.592000														56			34		0	0	0.006230	0	0
HR	55806	broad.mit.edu	37	8	21985008	21985008	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr8:21985008G>C	uc003xas.3	-	2	1612	c.947C>G	c.(946-948)tCt>tGt	p.S316C	HR_uc003xat.3_Missense_Mutation_p.S316C	NM_005144	NP_005135	O43593	HAIR_HUMAN	Homo sapiens hairless homolog (mouse) (HR), transcript variant 1, mRNA.	316							DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	27		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		CGGCTCAGGAGAGGGGCACCT	0.647000														6			23		0	0	0.003330	0	0
EVC2	132884	broad.mit.edu	37	4	5624453	5624453	+	Missense_Mutation	SNP	A	C	C			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr4:5624453A>C	uc003gij.3	-	13	2366	c.2312T>G	c.(2311-2313)cTc>cGc	p.L771R	EVC2_uc003gik.3_Missense_Mutation_p.L691R|EVC2_uc011bwb.2_Missense_Mutation_p.L211R	NM_147127	NP_667338	Q86UK5	LBN_HUMAN	Homo sapiens Ellis van Creveld syndrome 2 (EVC2), transcript variant 1, mRNA.	771						integral to membrane				NS(2)|breast(3)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(32)|lung(28)|ovary(4)|pancreas(1)|prostate(2)|skin(2)|stomach(1)|urinary_tract(2)	81						CTGCAGGAAGAGCCAGGGCAC	0.652000														52			3		0	0	0.004672	0	0
PRKAG1	5571	broad.mit.edu	37	12	49399093	49399093	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr12:49399093G>A	uc001rsy.3	-	4	411	c.305C>T	c.(304-306)gCc>gTc	p.A102V	PRKAG1_uc010smd.2_Missense_Mutation_p.A70V|PRKAG1_uc001rsz.3_Missense_Mutation_p.A111V|PRKAG1_uc010sme.2_Missense_Mutation_p.A102V	NM_002733	NP_001193639	P54619	AAKG1_HUMAN	Homo sapiens protein kinase, AMP-activated, gamma 1 non-catalytic subunit (PRKAG1), transcript variant 1, mRNA.	102	CBS 1.				cell cycle arrest|fatty acid biosynthetic process|insulin receptor signaling pathway|positive regulation of protein kinase activity|regulation of fatty acid oxidation|regulation of glycolysis|spermatogenesis	cytosol	cAMP-dependent protein kinase activity|cAMP-dependent protein kinase regulator activity|protein kinase binding			cervix(1)|endometrium(2)|kidney(2)|large_intestine(2)|lung(1)|upper_aerodigestive_tract(1)	9						CCTTACCAAGGCTGATTTATA	0.473000														73			58		0	0	0.014410	0	0
IQCF1	132141	broad.mit.edu	37	3	51937001	51937001	+	Splice_Site	SNP	C	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr3:51937001C>A	uc003dbv.3	-	2	206	c.108_splice	c.e2+1	p.E36_splice	IQCF1_uc003dbq.4_Splice_Site	NM_152397	NP_689610	Q8N6M8	IQCF1_HUMAN	Homo sapiens IQ motif containing F1 (IQCF1), mRNA.	36										central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(3)|ovary(1)|prostate(1)	12				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CTCCTCCTACCTCTGCCTTTG	0.493000														174			42		1.56793e-16	1.77698e-16	0.014410	1	0
IL7R	3575	broad.mit.edu	37	5	35873668	35873668	+	Silent	SNP	C	T	T			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr5:35873668C>T	uc003jjs.3	+	4	713	c.624C>T	c.(622-624)atC>atT	p.I208I	IL7R_uc011coo.2_Silent_p.I208I|IL7R_uc011cop.2_Intron	NM_002185	NP_002176	P16871	IL7RA_HUMAN	Homo sapiens interleukin 7 receptor (IL7R), mRNA.	208	Fibronectin type-III.				immune response|regulation of DNA recombination	extracellular region|integral to membrane	antigen binding|interleukin-7 receptor activity			NS(1)|breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(78)|kidney(2)|large_intestine(6)|lung(25)|ovary(3)|pancreas(1)|skin(5)|stomach(3)	126	all_lung(31;0.00015)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Epithelial(62;0.187)|Colorectal(62;0.202)			TTCGATCCATCCCTGATCACT	0.423000			"""Mis, O"""		"""ALL, ETP ALL"""		Severe combined immune deficiency							38			26		0	0	0.009535	0	0
OR51B4	79339	broad.mit.edu	37	11	5322673	5322673	+	Silent	SNP	G	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr11:5322673G>A	uc010qza.2	-	0	504	c.504C>T	c.(502-504)tcC>tcT	p.S168S	HBG1_uc001mak.1_Intron|HBE1_uc001mam.1_Intron	NM_033179	NP_149419	Q9Y5P0	O51B4_HUMAN	Homo sapiens olfactory receptor, family 51, subfamily B, member 4 (OR51B4), mRNA.	168					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.S168S(2)		breast(2)|central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(7)|pancreas(1)|skin(2)|upper_aerodigestive_tract(1)	20		Medulloblastoma(188;0.00225)|Breast(177;0.0155)|all_neural(188;0.0212)		Epithelial(150;2.76e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		AGAGGGCACGGGAACCACAAT	0.418000														55			22		0	0	0.003954	0	0
PCDH11Y	83259	broad.mit.edu	37	Y	5605718	5605718	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chrY:5605718C>T	uc004fqo.3	+	4	4492	c.3758C>T	c.(3757-3759)tCt>tTt	p.S1253F	PCDH11Y_uc022ciy.1_Non-coding_Transcript	NM_032973	NP_116755	Q9BZA8	PC11Y_HUMAN	Homo sapiens protocadherin 11 Y-linked (PCDH11Y), transcript variant c, mRNA.	1253					homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			autonomic_ganglia(1)|kidney(2)|large_intestine(7)|lung(14)|prostate(1)|skin(1)|upper_aerodigestive_tract(1)	27						CACAGCTCTTCTCTGCCACAG	0.547000														8			107		0	0	0.014410	0	0
CHRNA4	1137	broad.mit.edu	37	20	61981938	61981938	+	Missense_Mutation	SNP	G	C	C			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr20:61981938G>C	uc002yes.2	-	4	1003	c.825C>G	c.(823-825)atC>atG	p.I275M	CHRNA4_uc002yet.1_Missense_Mutation_p.I99M|CHRNA4_uc010gke.1_Missense_Mutation_p.I204M|CHRNA4_uc002yev.1_Missense_Mutation_p.I99M|CHRNA4_uc010gkf.1_Missense_Mutation_p.I99M	NM_000744	NP_000735	P43681	ACHA4_HUMAN	Homo sapiens cholinergic receptor, nicotinic, alpha 4 (CHRNA4), mRNA.	275					B cell activation|DNA repair|behavioral response to nicotine|calcium ion transport|cognition|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			breast(1)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(2)|lung(19)|prostate(3)|skin(3)|soft_tissue(1)	33	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	TGCACAGCGTGATCTTCTCGC	0.592000														41			35		0	0	0.005524	0	0
ALS2	57679	broad.mit.edu	37	2	202575791	202575791	+	Missense_Mutation	SNP	T	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr2:202575791T>A	uc002uyo.3	-	25	4401	c.4045A>T	c.(4045-4047)Agt>Tgt	p.S1349C	ALS2_uc010ftl.3_Non-coding_Transcript	NM_020919	NP_065970	Q96Q42	ALS2_HUMAN	Homo sapiens amyotrophic lateral sclerosis 2 (juvenile) (ALS2), transcript variant 1, mRNA.	1349					cell death|endosome organization|positive regulation of Rac GTPase activity|regulation of endosome size	centrosome|cytosol|early endosome|growth cone|lamellipodium|protein complex|ruffle	Rab GTPase binding|Rab guanyl-nucleotide exchange factor activity|Rac guanyl-nucleotide exchange factor activity|Ran guanyl-nucleotide exchange factor activity|protein homodimerization activity|protein serine/threonine kinase activator activity			NS(1)|breast(1)|central_nervous_system(2)|endometrium(11)|haematopoietic_and_lymphoid_tissue(1)|kidney(6)|large_intestine(15)|lung(22)|ovary(1)|prostate(4)|skin(6)|stomach(1)|upper_aerodigestive_tract(1)	72						AATTCCAAACTCTCTAGTGTC	0.348000														38			27		0	0	0.009535	0	0
TUBB2A	7280	broad.mit.edu	37	6	3155151	3155151	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr6:3155151C>T	uc003mvc.3	-	3	370	c.284G>A	c.(283-285)aGt>aAt	p.S95N	TUBB2A_uc003mvb.3_Missense_Mutation_p.S88N	NM_001069	NP_001060	Q13885	TBB2A_HUMAN	Homo sapiens tubulin, beta 2A class IIa (TUBB2A), mRNA.	95					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity			endometrium(2)|large_intestine(4)|lung(2)|skin(1)	9	Ovarian(93;0.0386)	all_hematologic(90;0.0895)				CCCGGCTCCACTCTGGCCTGC	0.512000														15			3		0	0	0.001855	0	0
SLCO2A1	6578	broad.mit.edu	37	3	133667504	133667504	+	Silent	SNP	G	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr3:133667504G>A	uc003eqa.4	-	7	1255	c.981C>T	c.(979-981)ctC>ctT	p.L327L	SLCO2A1_uc011blv.2_Silent_p.L146L	NM_005630	NP_005621	Q92959	SO2A1_HUMAN	Homo sapiens solute carrier organic anion transporter family, member 2A1 (SLCO2A1), mRNA.	327					sodium-independent organic anion transport	integral to plasma membrane|membrane fraction	prostaglandin transmembrane transporter activity|protein binding			breast(3)|central_nervous_system(1)|cervix(1)|endometrium(3)|large_intestine(5)|lung(10)|ovary(1)|prostate(2)|skin(2)|stomach(2)	30						CCAGGACGAAGAGTGAGTTCA	0.577000														70			61		0	0	0.014410	0	0
IL1RAPL1	11141	broad.mit.edu	37	X	29938181	29938181	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chrX:29938181C>T	uc004dby.2	+	7	1535	c.1027C>T	c.(1027-1029)Cga>Tga	p.R343*		NM_014271	NP_055086	Q9NZN1	IRPL1_HUMAN	Homo sapiens interleukin 1 receptor accessory protein-like 1 (IL1RAPL1), mRNA.	343	Ig-like C2-type 3.				innate immune response|negative regulation of calcium ion transport via voltage-gated calcium channel activity|negative regulation of exocytosis|regulation of neuron projection development	cytoplasm|integral to membrane|plasma membrane	protein binding|transmembrane receptor activity	p.R342P(2)|p.R343Q(1)|p.R343L(1)		biliary_tract(1)|breast(1)|endometrium(5)|large_intestine(9)|lung(38)|ovary(3)|pancreas(1)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(2)	62						AAATGGACGTCGACACGCCAG	0.433000														1			36		0	0	0.008740	0	0
MAEL	84944	broad.mit.edu	37	1	166990932	166990932	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr1:166990932C>T	uc001gdy.1	+	11	1216	c.1145C>T	c.(1144-1146)tCt>tTt	p.S382F	MAEL_uc021peh.1_Missense_Mutation_p.S326F|MAEL_uc001gdz.1_Missense_Mutation_p.S351F|MAEL_uc009wvf.1_Non-coding_Transcript	NM_032858	NP_116247	Q96JY0	MAEL_HUMAN	Homo sapiens maelstrom homolog (Drosophila) (MAEL), mRNA.	382					DNA methylation involved in gamete generation|cell differentiation|gene silencing by RNA|multicellular organismal development|piRNA metabolic process|spermatogenesis	piP-body	DNA binding			breast(2)|cervix(1)|endometrium(1)|kidney(1)|large_intestine(7)|lung(12)|skin(4)	28						GCAAAAATTTCTGGCCAAAAC	0.373000														64			19		0	0	0.002780	0	0
IKBKE	9641	broad.mit.edu	37	1	206658624	206658624	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr1:206658624C>T	uc001hdz.2	+	14	2175	c.1597C>T	c.(1597-1599)Cag>Tag	p.Q533*	IKBKE_uc001hea.2_Nonsense_Mutation_p.Q448*|IKBKE_uc009xbv.2_Nonsense_Mutation_p.Q533*	NM_014002	NP_001180250	Q14164	IKKE_HUMAN	Homo sapiens inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon (IKBKE), transcript variant 1, mRNA.	533					DNA damage response, signal transduction resulting in induction of apoptosis|MyD88-independent toll-like receptor signaling pathway|Toll signaling pathway|innate immune response|negative regulation of type I interferon production|positive regulation of I-kappaB kinase/NF-kappaB cascade|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	PML body|cytosol|endosome membrane|plasma membrane	ATP binding|IkappaB kinase activity|NF-kappaB-inducing kinase activity|protein binding			NS(1)|breast(1)|central_nervous_system(2)|endometrium(3)|kidney(1)|large_intestine(6)|lung(13)|ovary(3)|skin(2)	32	Breast(84;0.137)					GAGCCGGGATCAGGTACATGA	0.567000														49			15		0	0	0.006122	0	0
C15orf33	196951	broad.mit.edu	37	15	49869012	49869012	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr15:49869012C>T	uc001zxl.2	-	6	766	c.472G>A	c.(472-474)Gaa>Aaa	p.E158K	C15orf33_uc001zxm.3_Missense_Mutation_p.E158K	NM_152647	NP_689860	Q96M60	CO033_HUMAN	Homo sapiens chromosome 15 open reading frame 33 (C15orf33), mRNA.	158										endometrium(2)|kidney(2)|large_intestine(9)|lung(9)|ovary(1)|prostate(1)|urinary_tract(1)	25		all_lung(180;0.00187)		all cancers(107;3.45e-08)|GBM - Glioblastoma multiforme(94;0.000124)		TGAGTAAGTTCATTTGCTTTG	0.303000														17			13		0	0	0.002450	0	0
PREP	5550	broad.mit.edu	37	6	105729674	105729674	+	Nonsense_Mutation	SNP	C	T	T			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr6:105729674C>T	uc003prc.3	-	13	2018	c.1785G>A	c.(1783-1785)tgG>tgA	p.W595*		NM_002726	NP_002717	P48147	PPCE_HUMAN	Homo sapiens prolyl endopeptidase (PREP), mRNA.	595					proteolysis		serine-type endopeptidase activity			breast(1)|endometrium(2)|large_intestine(7)|lung(12)|ovary(3)|skin(1)|upper_aerodigestive_tract(2)|urinary_tract(1)	29		all_cancers(87;0.000128)|Acute lymphoblastic leukemia(125;1.9e-08)|all_hematologic(75;9.25e-07)|all_epithelial(87;0.0344)|Lung NSC(302;0.191)|Colorectal(196;0.202)			Oxytocin(DB00107)	AATCAGTGGTCCAAGCATGGC	0.398000														44			44		0	0	0.014410	0	0
PDC	5132	broad.mit.edu	37	1	186413385	186413385	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr1:186413385G>A	uc001gsa.3	-	3	540	c.467C>T	c.(466-468)aCa>aTa	p.T156I	MIR548F1_uc021pgf.1_Intron|PDC_uc001grz.3_Missense_Mutation_p.T104I	NM_002597	NP_072098	P20941	PHOS_HUMAN	Homo sapiens phosducin (PDC), transcript variant 1, mRNA.	156					G-protein coupled receptor protein signaling pathway|phototransduction|visual perception	actin cytoskeleton|cytosol|nucleus|photoreceptor inner segment|photoreceptor outer segment	phospholipase inhibitor activity			central_nervous_system(1)|endometrium(1)|large_intestine(2)|lung(1)|prostate(1)|skin(1)	7		Breast(1374;1.53e-05)		KIRC - Kidney renal clear cell carcinoma(1967;3.23e-08)|Colorectal(1306;0.0129)		TGCAAGGCATGTTAAACTACT	0.373000														70			29		0	0	0.004289	0	0
C10orf129	142827	broad.mit.edu	37	10	96967012	96967012	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr10:96967012C>T	uc001kke.3	+	3	576	c.451C>T	c.(451-453)Cgc>Tgc	p.R151C	C10orf129_uc009xuu.1_Missense_Mutation_p.R61C	NM_207321	NP_997204	Q6P461	ACSM6_HUMAN	Homo sapiens chromosome 10 open reading frame 129 (C10orf129), mRNA.	151					fatty acid metabolic process	mitochondrion	ATP binding|GTP binding|butyrate-CoA ligase activity|metal ion binding			breast(1)|kidney(2)|lung(1)|pancreas(1)|prostate(1)|skin(1)	7		Colorectal(252;0.083)		Epithelial(162;1.64e-06)|all cancers(201;3.71e-05)		CAAGAAAATTCGCTATCAATT	0.458000														5			35		0	0	0.006999	0	0
XRCC1	7515	broad.mit.edu	37	19	44048353	44048353	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr19:44048353C>T	uc002owt.2	-	14	1775	c.1655G>A	c.(1654-1656)gGg>gAg	p.G552E	XRCC1_uc010xwp.1_Missense_Mutation_p.G521E	NM_006297	NP_006288	P18887	XRCC1_HUMAN	Homo sapiens X-ray repair complementing defective repair in Chinese hamster cells 1 (XRCC1), mRNA.	552	BRCT 2.				base-excision repair|single strand break repair	nucleoplasm	damaged DNA binding|protein binding			breast(2)|endometrium(2)|large_intestine(4)|lung(6)|ovary(2)|prostate(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	19		Prostate(69;0.0153)				AGGGAACTCCCCGTAAAGAAA	0.577000								Other BER factors						10			6		0	0	0.004482	0	0
ALG9	79796	broad.mit.edu	37	11	111708291	111708291	+	Missense_Mutation	SNP	T	G	G			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr11:111708291T>G	uc010rwn.2	-	10	1312	c.1213A>C	c.(1213-1215)Aca>Cca	p.T405P	ALG9_uc001ply.3_Missense_Mutation_p.T280P|ALG9_uc001plz.3_Missense_Mutation_p.T287P|ALG9_uc021qql.1_Missense_Mutation_p.T280P|ALG9_uc021qqm.1_Missense_Mutation_p.T287P|ALG9_uc010rwo.2_Missense_Mutation_p.T279P|ALG9_uc009yyh.1_Missense_Mutation_p.T346P	NM_001077692	NP_001071160	Q9H6U8	ALG9_HUMAN	Homo sapiens asparagine-linked glycosylation 9, alpha-1,2-mannosyltransferase homolog (S. cerevisiae) (ALG9), transcript variant 4, mRNA.	451					GPI anchor biosynthetic process|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|intrinsic to endoplasmic reticulum membrane	alpha-1,2-mannosyltransferase activity			endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(4)|lung(6)|ovary(1)|skin(1)|upper_aerodigestive_tract(1)	16		all_cancers(61;2.34e-15)|all_epithelial(67;1.72e-09)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		Epithelial(105;6.81e-07)|BRCA - Breast invasive adenocarcinoma(274;1.15e-06)|all cancers(92;1.3e-05)|OV - Ovarian serous cystadenocarcinoma(223;0.0587)		GTTGGGTCTGTAGCAATTCGG	0.473000														12			21		0	0	0.005443	0	0
ZNF649	65251	broad.mit.edu	37	19	52394736	52394736	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr19:52394736T>C	uc002pxy.3	-	4	979	c.653A>G	c.(652-654)aAg>aGg	p.K218R	ZNF577_uc010ydf.1_5'Flank	NM_023074	NP_075562	Q9BS31	ZN649_HUMAN	Homo sapiens zinc finger protein 649 (ZNF649), mRNA.	218					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	29		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		GAGCCTGTACTTCTTGTAGAA	0.483000														86			4		0	0	0.001984	0	0
LRP2	4036	broad.mit.edu	37	2	170033017	170033017	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr2:170033017T>C	uc002ues.3	-	53	10688	c.10475A>G	c.(10474-10476)gAg>gGg	p.E3492G		NM_004525	NP_004516	P98164	LRP2_HUMAN	Homo sapiens low density lipoprotein receptor-related protein 2 (LRP2), mRNA.	3492	EGF-like 13.				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	SH3 domain binding|calcium ion binding|receptor activity			biliary_tract(1)|breast(16)|central_nervous_system(6)|cervix(2)|endometrium(24)|haematopoietic_and_lymphoid_tissue(2)|kidney(17)|large_intestine(70)|liver(1)|lung(117)|ovary(19)|pancreas(1)|prostate(2)|skin(17)|upper_aerodigestive_tract(7)|urinary_tract(13)	315				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	ATCTGGACACTCGCAAGTGAA	0.512000														36			34		0	0	0.004289	0	0
ZNF649	65251	broad.mit.edu	37	19	52394703	52394703	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr19:52394703C>T	uc002pxy.3	-	4	1012	c.686G>A	c.(685-687)aGa>aAa	p.R229K	ZNF577_uc010ydf.1_5'Flank	NM_023074	NP_075562	Q9BS31	ZN649_HUMAN	Homo sapiens zinc finger protein 649 (ZNF649), mRNA.	229					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)|central_nervous_system(1)|endometrium(1)|kidney(2)|large_intestine(4)|lung(12)|ovary(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)	29		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00152)|OV - Ovarian serous cystadenocarcinoma(262;0.0185)		TTTCTCTCCTCTGTGAGCTCT	0.488000														115			3		0	0	0.000602	0	0
CDK6	1021	broad.mit.edu	37	7	92300791	92300791	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr7:92300791G>A	uc011khw.2	-	4	1008	c.596C>T	c.(595-597)cCc>cTc	p.P199L	CDK6_uc010lez.3_Missense_Mutation_p.P199L	NM_001259	NP_001250	Q00534	CDK6_HUMAN	Homo sapiens cyclin-dependent kinase 6 (CDK6), transcript variant 1, mRNA.	199	Protein kinase.		P -> L (in a metastatic melanoma sample; somatic mutation).		G1 phase of mitotic cell cycle|cell dedifferentiation|cell division|gliogenesis|negative regulation of cell cycle|negative regulation of epithelial cell proliferation|negative regulation of osteoblast differentiation|positive regulation of cell-matrix adhesion|positive regulation of fibroblast proliferation|regulation of erythrocyte differentiation|regulation of gene expression|response to virus	cyclin-dependent protein kinase holoenzyme complex|cytosol|nucleus|ruffle	ATP binding|cyclin binding|cyclin-dependent protein kinase activity	p.P199L(2)		central_nervous_system(1)|endometrium(1)|kidney(1)|large_intestine(1)|lung(5)|skin(1)|urinary_tract(1)	11	all_cancers(62;8.72e-12)|all_epithelial(64;3.65e-10)|Breast(17;0.000675)|all_lung(186;0.0392)|Lung NSC(181;0.053)|all_neural(327;0.219)|all_hematologic(106;0.237)		STAD - Stomach adenocarcinoma(4;6.16e-07)|GBM - Glioblastoma multiforme(5;1.2e-06)|all cancers(6;3.1e-05)|LUSC - Lung squamous cell carcinoma(200;0.225)|Lung(22;0.23)			GAGATCCACGGGGGTGGCGTA	0.488000			T	MLLT10	ALL									108			29		0	0	0.004289	0	0
CECR1	51816	broad.mit.edu	37	22	17690464	17690464	+	Missense_Mutation	SNP	G	A	A	rs151283756		TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr22:17690464G>A	uc002zmk.1	-	0	316	c.104C>T	c.(103-105)gCg>gTg	p.A35V	CECR1_uc010gqu.1_Missense_Mutation_p.A35V|CECR1_uc011agi.1_5'UTR|CECR1_uc011agj.1_5'UTR	NM_017424	NP_059120	Q9NZK5	CECR1_HUMAN	Homo sapiens cat eye syndrome chromosome region, candidate 1 (CECR1), transcript variant 1, mRNA.	35	Dimerization.				adenosine catabolic process|hypoxanthine salvage|inosine biosynthetic process|multicellular organismal development|purine ribonucleoside monophosphate biosynthetic process	Golgi apparatus|extracellular space	adenosine deaminase activity|adenosine receptor binding|growth factor activity|heparin binding|protein homodimerization activity|proteoglycan binding|zinc ion binding	p.A35V(4)		endometrium(1)|kidney(2)|large_intestine(6)|liver(1)|lung(10)|ovary(2)|prostate(2)|stomach(1)	25		all_epithelial(15;0.0152)|Lung NSC(13;0.0875)|all_lung(157;0.106)				CAACAGATGCGCCCGTGTTTC	0.552000														31			59		0	0	0.014410	0	0
BOLL	66037	broad.mit.edu	37	2	198593229	198593229	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr2:198593229G>A	uc002uuu.1	-	11	1361	c.982C>T	c.(982-984)Cct>Tct	p.P328S	BC021693_uc002uup.3_Intron|BOLL_uc002uur.2_3'UTR|BOLL_uc002uus.2_3'UTR|BOLL_uc002uut.2_3'UTR|BOLL_uc010zha.1_3'UTR	NM_033030	NP_149019	Q8N9W6	BOLL_HUMAN	Homo sapiens bol, boule-like (Drosophila) (BOLL), transcript variant 2, mRNA.	0					cell differentiation|meiosis|multicellular organismal development|positive regulation of translational initiation|spermatogenesis	cytoplasm	RNA binding|nucleotide binding|protein binding|translation activator activity			central_nervous_system(1)|endometrium(2)|lung(6)|ovary(3)|prostate(1)	13						GCCACGCAAGGATCATTGGAC	0.413000														34			28		0	0	0.007291	0	0
MUC4	4585	broad.mit.edu	37	3	195505838	195505838	+	Missense_Mutation	SNP	G	C	C	rs59101491		TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr3:195505838G>C	uc021xjp.1	-	1	12769	c.12613C>G	c.(12613-12615)Cac>Gac	p.H4205D	MUC4_uc003fva.3_5'Flank|MUC4_uc003fvb.3_5'Flank|MUC4_uc003fvc.3_5'Flank|MUC4_uc003fvd.3_5'Flank|MUC4_uc003fve.3_5'Flank|MUC4_uc010hzr.3_5'Flank|MUC4_uc021xjm.1_Intron|MUC4_uc021xjn.1_Intron|MUC4_uc021xjo.1_Intron|MUC4_uc021xjg.1_Intron|MUC4_uc021xjh.1_Intron|MUC4_uc021xji.1_Intron|MUC4_uc021xjj.1_Intron|MUC4_uc021xjk.1_Intron|MUC4_uc021xjl.1_Intron|MUC4_uc003fvo.3_Intron|MUC4_uc003fvp.3_Intron	NM_018406	NP_060876	Q99102	MUC4_HUMAN	Homo sapiens mucin 4, cell surface associated (MUC4), transcript variant 1, mRNA.	968					cell-matrix adhesion	integral to plasma membrane|proteinaceous extracellular matrix	ErbB-2 class receptor binding|extracellular matrix constituent, lubricant activity	p.H4205D(2)		NS(1)|endometrium(4)|haematopoietic_and_lymphoid_tissue(3)|kidney(1)|large_intestine(5)|lung(23)|ovary(3)|prostate(8)|skin(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	51	all_cancers(143;1.11e-08)|Ovarian(172;0.0634)|Breast(254;0.206)	Lung NSC(153;0.191)	Epithelial(36;3.72e-24)|all cancers(36;6.22e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.1e-18)|Lung(62;4.65e-05)|LUSC - Lung squamous cell carcinoma(58;5.31e-05)	GBM - Glioblastoma multiforme(46;2.37e-05)		GGGGTGGCGTGACCTGTGGAT	0.597000														4			3		0	0	0.004672	0	0
PCDHAC2	56134	broad.mit.edu	37	5	140166400	140166400	+	Silent	SNP	T	C	C			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr5:140166400T>C	uc003lhb.2	+	0	525	c.525T>C	c.(523-525)agT>agC	p.S175S	PCDHAC2_uc003lha.2_Silent_p.S175S|PCDHAC2_uc003lgz.3_Silent_p.S175S	NM_018900	NP_061723	Q9Y5I4	PCDC2_HUMAN	Homo sapiens protocadherin alpha 1 (PCDHA1), transcript variant 1, mRNA.	190	Cadherin 2.				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding			NS(1)|breast(1)|endometrium(4)|kidney(4)|large_intestine(10)|liver(2)|lung(9)|ovary(2)|prostate(1)|skin(7)|upper_aerodigestive_tract(3)|urinary_tract(1)	45			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TCAGCCCGAGTGATTATTTCT	0.423000														67			12		0	0	0.013537	0	0
CCDC170	80129	broad.mit.edu	37	6	151914298	151914298	+	Silent	SNP	C	T	T			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr6:151914298C>T	uc003qol.3	+	7	1439	c.1350C>T	c.(1348-1350)gcC>gcT	p.A450A		NM_025059	NP_079335	Q8IYT3	CF097_HUMAN	Homo sapiens chromosome 6 open reading frame 97 (C6orf97), mRNA.	450																	AGATGGCTGCCGAACTTGGCT	0.448000														48			33		0	0	0.006230	0	0
RFX6	222546	broad.mit.edu	37	6	117243237	117243237	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr6:117243237G>A	uc003pxm.3	+	12	1423	c.1360G>A	c.(1360-1362)Gat>Aat	p.D454N		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	Homo sapiens regulatory factor X, 6 (RFX6), mRNA.	454					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			cervix(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(11)|lung(29)|ovary(1)|pancreas(1)|prostate(1)|skin(5)|upper_aerodigestive_tract(1)	59						AGAACTGAAGGATCTCCTTAA	0.353000														38			22		0	0	0.006320	0	0
ANKRD24	170961	broad.mit.edu	37	19	4222681	4222681	+	Silent	SNP	C	T	T			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr19:4222681C>T	uc010dtt.1	+	19	3462	c.3186C>T	c.(3184-3186)tcC>tcT	p.S1062S		NM_133475	NP_597732	Q8TF21	ANR24_HUMAN	Homo sapiens ankyrin repeat domain 24 (ANKRD24), mRNA.	1062										endometrium(3)|haematopoietic_and_lymphoid_tissue(2)|kidney(1)|large_intestine(4)|lung(9)|prostate(1)|skin(1)	21				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|BRCA - Breast invasive adenocarcinoma(158;0.0233)|STAD - Stomach adenocarcinoma(1328;0.181)		CAGAACTCTCCAAAGAAGTCT	0.602000														16			3		0	0	0.009096	0	0
KCNK9	51305	broad.mit.edu	37	8	140630645	140630645	+	Silent	SNP	G	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr8:140630645G>A	uc003yvf.1	-	1	1045	c.981C>T	c.(979-981)ttC>ttT	p.F327F	KCNK9_uc003yvg.1_Silent_p.F327F|KCNK9_uc003yve.1_Non-coding_Transcript	NM_016601	NP_057685	Q9NPC2	KCNK9_HUMAN	Homo sapiens potassium channel, subfamily K, member 9 (KCNK9), mRNA.	327						integral to membrane|membrane fraction	potassium channel activity|voltage-gated ion channel activity	p.F327F(2)		NS(1)|endometrium(9)|kidney(1)|large_intestine(9)|lung(17)|ovary(2)|prostate(3)|skin(1)	43	all_cancers(97;3.94e-14)|all_epithelial(106;4.81e-13)|Lung NSC(106;8.18e-05)|all_lung(105;0.00015)|Ovarian(258;0.00235)|Acute lymphoblastic leukemia(118;0.155)	Ovarian(118;0.134)	BRCA - Breast invasive adenocarcinoma(115;0.0855)			AGATGGAGTGGAAGTAGTGGG	0.557000														100			49		0	0	0.014410	0	0
MYT1	4661	broad.mit.edu	37	20	62839564	62839564	+	Nonsense_Mutation	SNP	G	T	T			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr20:62839564G>T	uc002yii.3	+	6	1379	c.1015G>T	c.(1015-1017)Gag>Tag	p.E339*	MYT1_uc002yih.3_Intron|MYT1_uc002yij.3_5'UTR	NM_004535	NP_004526	Q01538	MYT1_HUMAN	Homo sapiens myelin transcription factor 1 (MYT1), mRNA.	339					cell differentiation|nervous system development	nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding	p.P338S(1)		breast(4)|central_nervous_system(1)|cervix(1)|endometrium(4)|kidney(3)|large_intestine(12)|liver(1)|lung(17)|ovary(5)|prostate(2)|skin(2)|soft_tissue(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	55	all_cancers(38;1.82e-11)|all_epithelial(29;3.3e-13)|Lung NSC(23;5.21e-10)|all_lung(23;1.92e-09)					TCCCAAGCCTGAGTACTCTGT	0.577000														97			68		4.81439e-37	5.58032e-37	0.014410	1	0
OR13C2	392376	broad.mit.edu	37	9	107367080	107367080	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr9:107367080C>T	uc011lvq.2	-	0	829	c.829G>A	c.(829-831)Gac>Aac	p.D277N		NM_001004481	NP_001004481	Q8NGS9	O13C2_HUMAN	Homo sapiens olfactory receptor, family 13, subfamily C, member 2 (OR13C2), mRNA.	277					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.T276I(1)		cervix(1)|endometrium(1)|kidney(1)|large_intestine(4)|lung(10)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)	22						ATAATTTTGTCGGTAGCATCC	0.403000														66			34		0	0	0.004289	0	0
MLL5	55904	broad.mit.edu	37	7	104722214	104722214	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr7:104722214C>T	uc003vcm.3	+	12	1862	c.1328C>T	c.(1327-1329)aCt>aTt	p.T443I	MLL5_uc010lja.1_Missense_Mutation_p.T297I|MLL5_uc010ljb.1_Missense_Mutation_p.T443I|MLL5_uc003vcl.3_Missense_Mutation_p.T443I|MLL5_uc010ljc.3_Missense_Mutation_p.T443I|MLL5_uc003vco.1_Non-coding_Transcript|MLL5_uc010ljd.1_Missense_Mutation_p.T81I	NM_182931	NP_891847	Q8IZD2	MLL5_HUMAN	Homo sapiens myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila) (MLL5), transcript variant 1, mRNA.	443	SET.				DNA methylation|cell cycle arrest|cellular response to retinoic acid|erythrocyte differentiation|neutrophil activation|neutrophil mediated immunity|positive regulation of granulocyte differentiation|positive regulation of transcription, DNA-dependent|retinoic acid receptor signaling pathway|transcription, DNA-dependent	MLL5-L complex|nuclear speck	enzyme binding|histone methyltransferase activity (H3-K4 specific)|transcription coactivator activity|zinc ion binding			NS(1)|breast(5)|endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(8)|large_intestine(20)|lung(13)|ovary(3)|pancreas(1)|prostate(3)|skin(3)|upper_aerodigestive_tract(2)	63						ACTGAAATTACTATTGCCTTT	0.294000														150			4		0	0	0.000602	0	0
OR8H2	390151	broad.mit.edu	37	11	55872882	55872882	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr11:55872882C>T	uc010riy.2	+	0	364	c.364C>T	c.(364-366)Cgc>Tgc	p.R122C		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	Homo sapiens olfactory receptor, family 8, subfamily H, member 2 (OR8H2), mRNA.	122					sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity	p.R122C(2)|p.R122R(1)		breast(1)|cervix(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(2)|large_intestine(5)|lung(38)|ovary(1)|skin(3)|stomach(2)|upper_aerodigestive_tract(5)|urinary_tract(1)	61	Esophageal squamous(21;0.00693)					GGCCCATGATCGCTATGCAGC	0.458000										HNSCC(53;0.14)				65			102		0	0	0.014410	0	0
FMO1	2326	broad.mit.edu	37	1	171244557	171244557	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr1:171244557G>A	uc009wvz.3	+	3	530	c.394G>A	c.(394-396)Gaa>Aaa	p.E132K	FMO1_uc010pme.2_Missense_Mutation_p.E69K|FMO1_uc001ghl.3_Missense_Mutation_p.E132K|FMO1_uc001ghm.3_Missense_Mutation_p.E132K	NM_002021	NP_002012	Q01740	FMO1_HUMAN	Homo sapiens flavin containing monooxygenase 1 (FMO1), mRNA.	132					NADPH oxidation|organic acid metabolic process|toxin metabolic process|xenobiotic metabolic process	endoplasmic reticulum lumen|integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	NADP binding|flavin adenine dinucleotide binding|flavin-containing monooxygenase activity			NS(1)|breast(2)|endometrium(2)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(4)|lung(13)|prostate(2)|skin(2)	27	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CACTATGCATGAAGAGAAGCA	0.433000														118			54		0	0	0.014410	0	0
CCND2	894	broad.mit.edu	37	12	4385346	4385346	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr12:4385346G>A	uc001qmo.3	+	1	676	c.371G>A	c.(370-372)tGc>tAc	p.C124Y		NM_001759	NP_001750	P30279	CCND2_HUMAN	Homo sapiens cyclin D2 (CCND2), mRNA.	124	Cyclin N-terminal.				cell division|positive regulation of cyclin-dependent protein kinase activity|positive regulation of protein phosphorylation	cyclin-dependent protein kinase holoenzyme complex|cytoplasm|membrane|nucleus	protein kinase binding			breast(1)|central_nervous_system(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(3)|large_intestine(1)|lung(7)|prostate(1)|upper_aerodigestive_tract(1)	17			all cancers(3;4.15e-10)|GBM - Glioblastoma multiforme(3;6.34e-05)|Colorectal(7;0.00245)|OV - Ovarian serous cystadenocarcinoma(31;0.00301)|COAD - Colon adenocarcinoma(12;0.0264)|STAD - Stomach adenocarcinoma(119;0.206)			GAGAAGCTGTGCATTTACACC	0.582000			T	IGL@	"""NHL,CLL"""									25			9		0	0	0.013537	0	0
ADAMTS6	11174	broad.mit.edu	37	5	64484041	64484041	+	Silent	SNP	G	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr5:64484041G>A	uc003jtp.3	-	21	3526	c.2712C>T	c.(2710-2712)ttC>ttT	p.F904F	ADAMTS6_uc003jto.3_Non-coding_Transcript|ADAMTS6_uc003jtq.3_Non-coding_Transcript	NM_197941	NP_922932	Q9UKP5	ATS6_HUMAN	Homo sapiens ADAM metallopeptidase with thrombospondin type 1 motif, 6 (ADAMTS6), mRNA.	904	TSP type-1 3.				proteolysis	proteinaceous extracellular matrix	metalloendopeptidase activity|zinc ion binding			breast(2)|cervix(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(1)|lung(7)|pancreas(1)|prostate(1)|skin(3)	18		Lung NSC(167;2.44e-06)|Prostate(74;0.014)|Ovarian(174;0.0549)|Breast(144;0.111)|Colorectal(97;0.235)		Lung(70;0.00942)		AATCCCCAATGAACCACCTGC	0.498000														74			63		0	0	0.014410	0	0
ALDH4A1	8659	broad.mit.edu	37	1	19204081	19204081	+	Silent	SNP	G	A	A	rs150927009		TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr1:19204081G>A	uc001bbb.3	-	9	1242	c.966C>T	c.(964-966)ttC>ttT	p.F322F	ALDH4A1_uc010ocu.2_Silent_p.F262F|ALDH4A1_uc001bbc.3_Silent_p.F322F|ALDH4A1_uc021ohl.1_Silent_p.F322F	NM_170726	NP_001154976	P30038	AL4A1_HUMAN	Homo sapiens aldehyde dehydrogenase 4 family, member A1 (ALDH4A1), nuclear gene encoding mitochondrial protein, transcript variant P5CDhS, mRNA.	322					proline biosynthetic process|proline catabolic process	mitochondrial matrix	1-pyrroline-5-carboxylate dehydrogenase activity|aldehyde dehydrogenase (NAD) activity|electron carrier activity	p.F322F(6)		cervix(2)|endometrium(1)|large_intestine(3)|lung(8)|prostate(1)	15		Colorectal(325;3.46e-05)|all_lung(284;0.000321)|Lung NSC(340;0.000398)|Renal(390;0.000518)|Breast(348;0.000812)|Ovarian(437;0.00764)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.00479)|BRCA - Breast invasive adenocarcinoma(304;3.67e-05)|Kidney(64;0.000182)|KIRC - Kidney renal clear cell carcinoma(64;0.00269)|STAD - Stomach adenocarcinoma(196;0.00644)|READ - Rectum adenocarcinoma(331;0.0649)	NADH(DB00157)	AGCGGTGCACGAAGTGGAAGT	0.657000														34			17		0	0	0.012319	0	0
TFEC	22797	broad.mit.edu	37	7	115580613	115580613	+	Missense_Mutation	SNP	C	T	T			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr7:115580613C>T	uc003vhj.2	-	7	1289	c.1036G>A	c.(1036-1038)Gaa>Aaa	p.E346K	TFEC_uc003vhm.2_Missense_Mutation_p.E279K|TFEC_uc003vhk.2_Missense_Mutation_p.E317K|TFEC_uc003vhl.4_3'UTR|TFEC_uc011kmw.2_3'UTR	NM_012252	NP_036384	O14948	TFEC_HUMAN	Homo sapiens transcription factor EC (TFEC), transcript variant 1, mRNA.	346	Necessary for transcriptional transactivation.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity|transcription corepressor activity			NS(1)|kidney(1)|large_intestine(5)|lung(13)|prostate(2)|skin(1)|urinary_tract(2)	25			STAD - Stomach adenocarcinoma(10;0.00878)			TCTTATAATTCATCACCATCA	0.398000														69			19		0	0	0.010504	0	0
STAT3	6774	broad.mit.edu	37	17	40481782	40481782	+	Silent	SNP	G	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr17:40481782G>A	uc002hzl.1	-	11	1362	c.1122C>T	c.(1120-1122)gaC>gaT	p.D374D	STAT3_uc002hzk.1_Silent_p.D374D|STAT3_uc002hzm.1_Silent_p.D374D|STAT3_uc010wgh.1_Silent_p.D276D|STAT3_uc002hzn.1_Silent_p.D374D	NM_139276	NP_644805	P40763	STAT3_HUMAN	Homo sapiens signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 1, mRNA.	374					JAK-STAT cascade involved in growth hormone signaling pathway|cellular component movement|eating behavior|eye photoreceptor cell differentiation|glucose homeostasis|interleukin-6-mediated signaling pathway|interspecies interaction between organisms|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|protein import into nucleus|response to estradiol stimulus|sexual reproduction|temperature homeostasis	cytosol|nucleus|plasma membrane	calcium ion binding|ligand-regulated transcription factor activity|protein dimerization activity|protein kinase binding|sequence-specific DNA binding transcription factor activity|signal transducer activity|transcription factor binding|transcription regulatory region DNA binding			breast(3)|central_nervous_system(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(4)|kidney(2)|large_intestine(3)|lung(12)|ovary(1)|prostate(4)|stomach(1)|upper_aerodigestive_tract(1)|urinary_tract(1)	35		all_cancers(22;1.39e-06)|all_epithelial(22;2.95e-05)|Breast(137;0.000135)		BRCA - Breast invasive adenocarcinoma(366;0.139)		GAGCTGCAACGTCCCCAGAGT	0.428000									Hyperimmunoglobulin E Recurrent Infection Syndrome					21			21		0	0	0.003954	0	0
LOC729020	729020	broad.mit.edu	37	10	105005757	105005757	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr10:105005757G>A	uc009xxi.2	+	0	114	c.4G>A	c.(4-6)Gcg>Acg	p.A2T	BC040734_uc001kwr.3_Intron	NM_001143909	NP_001137381	Q2QD12	Q2QD12_HUMAN	Homo sapiens rcRPE (LOC729020), mRNA.	2					carbohydrate metabolic process		ribulose-phosphate 3-epimerase activity										CAGCGGTATGGCGTCGGGCTG	0.527000														8			14		0	0	0.007413	0	0
KRTAP4-12	83755	broad.mit.edu	37	17	39280087	39280087	+	Silent	SNP	G	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr17:39280087G>A	uc002hwa.3	-	0	333	c.288C>T	c.(286-288)tgC>tgT	p.C96C		NM_031854	NP_114060	Q9BQ66	KR412_HUMAN	Homo sapiens keratin associated protein 4-12 (KRTAP4-12), mRNA.	96	31 X 5 AA repeats of C-C-[GRQVIL]-[SPTR]- [VSTQPC].					keratin filament		p.C96C(4)		endometrium(3)|haematopoietic_and_lymphoid_tissue(1)|kidney(1)|large_intestine(5)|lung(1)|prostate(1)|upper_aerodigestive_tract(1)	13		Breast(137;0.000496)	STAD - Stomach adenocarcinoma(17;0.000371)			AGGTGGGCTGGCAGCACACAG	0.667000														162			5		0	0	0.001168	0	0
FAT4	79633	broad.mit.edu	37	4	126238008	126238008	+	Missense_Mutation	SNP	A	T	T			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr4:126238008A>T	uc003ifj.4	+	0	442	c.442A>T	c.(442-444)Agt>Tgt	p.S148C		NM_024582	NP_078858	Q6V0I7	FAT4_HUMAN	Homo sapiens FAT tumor suppressor homolog 4 (Drosophila) (FAT4), mRNA.	148	Cadherin 2.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			NS(6)|autonomic_ganglia(1)|breast(4)|central_nervous_system(3)|cervix(3)|endometrium(27)|haematopoietic_and_lymphoid_tissue(3)|kidney(10)|large_intestine(93)|liver(3)|lung(120)|ovary(9)|pancreas(2)|prostate(21)|skin(31)|stomach(1)|upper_aerodigestive_tract(12)|urinary_tract(6)	355						CAAGGAAGACAGTAGCAGCGG	0.607000											OREG0016317	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)		16			16		0	0	0.007413	0	0
ABCD3	5825	broad.mit.edu	37	1	94933537	94933537	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr1:94933537G>A	uc010oto.2	+	4	483	c.381G>A	c.(379-381)atG>atA	p.M127I	ABCD3_uc001dqm.4_Missense_Mutation_p.M103I|ABCD3_uc001dqn.4_Missense_Mutation_p.M103I|ABCD3_uc010otp.2_Missense_Mutation_p.M30I|ABCD3_uc009wdr.3_Missense_Mutation_p.M103I	NM_002858	NP_002849	P28288	ABCD3_HUMAN	Homo sapiens ATP-binding cassette, sub-family D (ALD), member 3 (ABCD3), transcript variant 1, mRNA.	103	ABC transmembrane type-1.|Interaction with PEX19.				peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			breast(1)|endometrium(1)|kidney(3)|large_intestine(5)|liver(2)|lung(10)|ovary(1)|pancreas(1)|skin(2)	26		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		ATGTTTGGATGATTCAAAATG	0.308000														39			26		0	0	0.009535	0	0
DPYD	1806	broad.mit.edu	37	1	98187190	98187190	+	Missense_Mutation	SNP	T	C	C			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr1:98187190T>C	uc001drv.3	-	4	496	c.359A>G	c.(358-360)aAc>aGc	p.N120S	DPYD_uc010oub.1_Non-coding_Transcript|DPYD_uc001drw.3_Missense_Mutation_p.N120S	NM_000110	NP_000101	Q12882	DPYD_HUMAN	Homo sapiens dihydropyrimidine dehydrogenase (DPYD), transcript variant 1, mRNA.	120					'de novo' pyrimidine base biosynthetic process|UMP biosynthetic process|purine base catabolic process|thymidine catabolic process|thymine catabolic process|uracil catabolic process	cytosol	4 iron, 4 sulfur cluster binding|NADP binding|dihydroorotate oxidase activity|dihydropyrimidine dehydrogenase (NADP+) activity|electron carrier activity|flavin adenine dinucleotide binding|metal ion binding|protein homodimerization activity			NS(2)|breast(4)|central_nervous_system(1)|endometrium(5)|haematopoietic_and_lymphoid_tissue(3)|kidney(2)|large_intestine(18)|lung(30)|ovary(4)|prostate(6)|skin(7)|upper_aerodigestive_tract(1)	83		all_epithelial(167;0.000185)|all_lung(203;0.00318)|Lung NSC(277;0.00994)		Colorectal(170;0.0165)|Epithelial(280;0.0526)|all cancers(265;0.104)|READ - Rectum adenocarcinoma(84;0.171)|Lung(183;0.216)	Capecitabine(DB01101)|Enfuvirtide(DB00109)	ACCAAGTGGGTTGTCAGAAAA	0.338000														66			46		0	0	0.014410	0	0
FCGBP	8857	broad.mit.edu	37	19	40434213	40434213	+	Splice_Site	SNP	C	T	T			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr19:40434213C>T	uc002omp.4	-	2	64	c.56_splice	c.e2-1	p.G19_splice		NM_003890	NP_003881	Q9Y6R7	FCGBP_HUMAN	Homo sapiens Fc fragment of IgG binding protein (FCGBP), mRNA.	19						extracellular region	protein binding			NS(3)|autonomic_ganglia(1)|breast(7)|central_nervous_system(5)|endometrium(13)|kidney(9)|large_intestine(27)|lung(49)|ovary(8)|pancreas(3)|prostate(13)|skin(9)|stomach(9)|upper_aerodigestive_tract(6)|urinary_tract(3)	165	all_cancers(60;6.03e-06)|all_lung(34;5.58e-08)|Lung NSC(34;6.62e-08)|Ovarian(47;0.06)		Epithelial(26;6.25e-23)|all cancers(26;1.13e-20)			CTGGGTCAATCCTGGTTGAGA	0.502000														19			21		0	0	0.014323	0	0
FCHO1	23149	broad.mit.edu	37	19	17885062	17885062	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr19:17885062G>A	uc002nhg.3	+	11	1084	c.805G>A	c.(805-807)Gag>Aag	p.E269K	FCHO1_uc010ebb.2_Missense_Mutation_p.E269K|FCHO1_uc002nhh.2_Missense_Mutation_p.E269K|FCHO1_uc010xpw.1_Missense_Mutation_p.E219K|FCHO1_uc010ebc.1_Missense_Mutation_p.E276K	NM_001161357	NP_001154829	O14526	FCHO1_HUMAN	Homo sapiens FCH domain only 1 (FCHO1), transcript variant 1, mRNA.	269										NS(2)|breast(1)|large_intestine(6)|liver(1)|lung(12)	22						TCTGGACTTCGAGGCATACAG	0.607000														35			15		0	0	0.006122	0	0
FAM83E	54854	broad.mit.edu	37	19	49104408	49104408	+	Silent	SNP	C	T	T			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr19:49104408C>T	uc002pjn.2	-	4	1460	c.1395G>A	c.(1393-1395)ccG>ccA	p.P465P		NM_017708	NP_060178	Q2M2I3	FA83E_HUMAN	Homo sapiens family with sequence similarity 83, member E (FAM83E), mRNA.	465										NS(1)|endometrium(2)|large_intestine(1)|lung(3)|ovary(1)|urinary_tract(2)	10		all_epithelial(76;2.38e-06)|all_lung(116;4.89e-06)|Lung NSC(112;9.34e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)		OV - Ovarian serous cystadenocarcinoma(262;0.000102)|all cancers(93;0.000117)|GBM - Glioblastoma multiforme(486;0.00627)|Epithelial(262;0.0158)		CCCAGTCTGACGGCCTGACGC	0.667000														23			27		0	0	0.007291	0	0
ZNF57	126295	broad.mit.edu	37	19	2917733	2917733	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr19:2917733G>A	uc002lwr.3	+	3	1262	c.1114G>A	c.(1114-1116)Gcc>Acc	p.A372T	ZNF57_uc010xha.2_Missense_Mutation_p.A340T	NM_173480	NP_775751	Q68EA5	ZNF57_HUMAN	Homo sapiens zinc finger protein 57 (ZNF57), mRNA.	372					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			endometrium(1)|kidney(2)|large_intestine(5)|lung(2)|ovary(1)|pancreas(1)|prostate(1)|skin(3)|upper_aerodigestive_tract(1)|urinary_tract(1)	18				UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|GBM - Glioblastoma multiforme(1328;0.00161)|STAD - Stomach adenocarcinoma(1328;0.18)		ATGTGGGAAAGCCTTCACTTG	0.443000														61			3		0	0	0.009096	0	0
BRAF	673	broad.mit.edu	37	7	140453136	140453136	+	Missense_Mutation	SNP	A	T	T	rs121913377		TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr7:140453136A>T	uc003vwc.4	-	14	1860	c.1799T>A	c.(1798-1800)gTg>gAg	p.V600E		NM_004333	NP_004324	P15056	BRAF_HUMAN	Homo sapiens v-raf murine sarcoma viral oncogene homolog B1 (BRAF), mRNA.	600	Protein kinase.		V -> D (in a melanoma cell line; requires 2 nucleotide substitutions).|V -> E (in sarcoma, colorectal adenocarcinoma, metastatic melanoma, ovarian serous carcinoma, pilocytic astrocytoma; somatic mutation; most common mutation; constitutive and elevated kinase activity; efficiently induces cell transformation; suppression of mutation in melanoma causes growth arrest and promotes apoptosis).		activation of MAPKK activity|anti-apoptosis|nerve growth factor receptor signaling pathway|organ morphogenesis|positive regulation of peptidyl-serine phosphorylation|small GTPase mediated signal transduction|synaptic transmission	cytosol|nucleus|plasma membrane	ATP binding|metal ion binding	p.V600E(41204)|p.V600K(615)|p.V600?(377)|p.V600R(99)|p.V600D(40)|p.V600_K601>E(30)|p.V600L(28)|p.V600A(24)|p.V600G(22)|p.V600M(22)|p.A598_T599insV(7)|p.T599_V600insT(7)|p.T599I(5)|p.V600Q(4)|p.T599_R603>I(4)|p.T599_V600insTT(3)|p.T599_V600insDFGLAT(2)|p.T599_V600>IAL(2)|p.V600_S605>EK(2)|p.T599T(2)|p.V600_S605>DV(2)|p.V600_S605>D(2)|p.V600_W604del(1)|p.V600V(1)|p.T599_V600insV(1)|p.V600>DLAT(1)|p.D594_T599del(1)	SLC45A3/BRAF(2)|AGTRAP/BRAF(2)|FAM131B_ENST00000443739/BRAF(7)|AKAP9_ENST00000356239/BRAF(10)|KIAA1549/BRAF(703)|FCHSD1/BRAF(2)	NS(588)|adrenal_gland(3)|autonomic_ganglia(3)|biliary_tract(29)|bone(7)|breast(21)|central_nervous_system(99)|cervix(6)|endometrium(33)|eye(72)|gastrointestinal_tract_(site_indeterminate)(2)|genital_tract(4)|haematopoietic_and_lymphoid_tissue(436)|kidney(3)|large_intestine(6953)|liver(17)|lung(192)|oesophagus(4)|ovary(275)|pancreas(15)|pituitary(1)|prostate(25)|salivary_gland(1)|skin(6285)|small_intestine(12)|soft_tissue(40)|stomach(11)|testis(7)|thyroid(12220)|upper_aerodigestive_tract(13)|urinary_tract(3)	27380	Melanoma(164;0.00956)				Sorafenib(DB00398)	TCGAGATTTCACTGTAGCTAG	0.368000	V600D(K029AX_SKIN)|V600D(WM115_SKIN)|V600D(WM2664_SKIN)|V600E(8505C_THYROID)|V600E(A101D_SKIN)|V600E(A2058_SKIN)|V600E(A375_SKIN)|V600E(A673_BONE)|V600E(AM38_CENTRAL_NERVOUS_SYSTEM)|V600E(BCPAP_THYROID)|V600E(BHT101_THYROID)|V600E(BT474_BREAST)|V600E(C32_SKIN)|V600E(CL34_LARGE_INTESTINE)|V600E(COLO205_LARGE_INTESTINE)|V600E(COLO679_SKIN)|V600E(COLO741_SKIN)|V600E(COLO783_SKIN)|V600E(COLO800_SKIN)|V600E(COLO818_SKIN)|V600E(COLO829_SKIN)|V600E(COLO849_SKIN)|V600E(DBTRG05MG_CENTRAL_NERVOUS_SYSTEM)|V600E(DU4475_BREAST)|V600E(ES2_OVARY)|V600E(G361_SKIN)|V600E(GCT_SOFT_TISSUE)|V600E(HS294T_SKIN)|V600E(HS695T_SKIN)|V600E(HS939T_SKIN)|V600E(IGR1_SKIN)|V600E(IGR37_SKIN)|V600E(IGR39_SKIN)|V600E(K029AX_SKIN)|V600E(KG1C_CENTRAL_NERVOUS_SYSTEM)|V600E(LOXIMVI_SKIN)|V600E(MALME3M_SKIN)|V600E(MELHO_SKIN)|V600E(OUMS23_LARGE_INTESTINE)|V600E(RKO_LARGE_INTESTINE)|V600E(RPMI7951_SKIN)|V600E(RVH421_SKIN)|V600E(SH4_SKIN)|V600E(SIGM5_HAEMATOPOIETIC_AND_LYMPHOID_TISSUE)|V600E(SKHEP1_LIVER)|V600E(SKMEL24_SKIN)|V600E(SKMEL28_SKIN)|V600E(SKMEL5_SKIN)|V600E(SW1417_LARGE_INTESTINE)|V600E(UACC257_SKIN)|V600E(UACC62_SKIN)|V600E(WM793_SKIN)|V600E(WM88_SKIN)|V600E(WM983B_SKIN)	61	"""Mis, T, O"""	"""AKAP9, KIAA1549"""	"""melanoma, colorectal, papillary thyroid, borderline ov, Non small-cell lung cancer (NSCLC), cholangiocarcinoma, pilocytic astrocytoma"""		Cardio-facio-cutaneous syndrome		Cardiofaciocutaneous syndrome					65			74		0	0	0.014410	0	0
HR	55806	broad.mit.edu	37	8	21984959	21984959	+	Silent	SNP	G	T	T			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr8:21984959G>T	uc003xas.3	-	2	1661	c.996C>A	c.(994-996)ccC>ccA	p.P332P	HR_uc003xat.3_Silent_p.P332P	NM_005144	NP_005135	O43593	HAIR_HUMAN	Homo sapiens hairless homolog (mouse) (HR), transcript variant 1, mRNA.	332							DNA binding|metal ion binding|sequence-specific DNA binding transcription factor activity			central_nervous_system(1)|endometrium(3)|kidney(2)|large_intestine(3)|lung(12)|ovary(2)|prostate(3)|upper_aerodigestive_tract(1)	27		Breast(100;0.000162)|Acute lymphoblastic leukemia(644;0.0775)|Prostate(55;0.116)		KIRC - Kidney renal clear cell carcinoma(542;1.19e-05)|BRCA - Breast invasive adenocarcinoma(99;3.56e-05)|Colorectal(74;0.00191)|COAD - Colon adenocarcinoma(73;0.0615)|READ - Rectum adenocarcinoma(644;0.1)		CACCTTTAGTGGGTGGGTAGG	0.647000														17			34		1.57351e-24	1.80335e-24	0.003755	1	0
SNED1	25992	broad.mit.edu	37	2	242011284	242011284	+	Missense_Mutation	SNP	G	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr2:242011284G>A	uc002wah.1	+	25	3808	c.3808G>A	c.(3808-3810)Gtg>Atg	p.V1270M	SNED1_uc002wai.1_Missense_Mutation_p.V505M|SNED1_uc002waj.1_Missense_Mutation_p.V357M|SNED1_uc002wak.3_Missense_Mutation_p.V357M|SNED1_uc002wal.3_Missense_Mutation_p.V97M	NM_001080437	NP_001073906	Q8TER0	SNED1_HUMAN	Homo sapiens sushi, nidogen and EGF-like domains 1 (SNED1), mRNA.	1270					cell-matrix adhesion	extracellular region	calcium ion binding			NS(1)|breast(1)|central_nervous_system(3)|kidney(2)|large_intestine(6)|lung(4)|ovary(3)|prostate(3)|upper_aerodigestive_tract(1)	24		all_cancers(19;7.48e-31)|all_epithelial(40;1.35e-12)|Breast(86;0.000148)|Renal(207;0.00528)|Ovarian(221;0.104)|Esophageal squamous(248;0.131)|all_lung(227;0.17)|all_hematologic(139;0.182)|Melanoma(123;0.238)		Epithelial(32;6.46e-32)|all cancers(36;6.23e-29)|OV - Ovarian serous cystadenocarcinoma(60;2.1e-14)|Kidney(56;6.35e-09)|KIRC - Kidney renal clear cell carcinoma(57;5.98e-08)|BRCA - Breast invasive adenocarcinoma(100;3.66e-06)|Lung(119;0.00072)|LUSC - Lung squamous cell carcinoma(224;0.00553)|Colorectal(34;0.0162)|COAD - Colon adenocarcinoma(134;0.109)		AGCAGCCACCGTGAGATCACG	0.642000														8			7		0	0	0.004482	0	0
SLCO4C1	353189	broad.mit.edu	37	5	101592950	101592950	+	Silent	SNP	G	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr5:101592950G>A	uc003knm.3	-	7	1625	c.1338C>T	c.(1336-1338)ttC>ttT	p.F446F		NM_180991	NP_851322	Q6ZQN7	SO4C1_HUMAN	Homo sapiens solute carrier organic anion transporter family, member 4C1 (SLCO4C1), mRNA.	446					cell differentiation|multicellular organismal development|sodium-independent organic anion transport|spermatogenesis	basolateral plasma membrane|integral to membrane	sodium-independent organic anion transmembrane transporter activity			breast(1)|central_nervous_system(1)|haematopoietic_and_lymphoid_tissue(1)|kidney(4)|large_intestine(12)|lung(16)|ovary(1)|pancreas(1)|prostate(4)|skin(2)|upper_aerodigestive_tract(2)|urinary_tract(5)	50		all_cancers(142;1.86e-08)|all_epithelial(76;5.24e-12)|Prostate(80;0.00124)|Colorectal(57;0.00332)|Ovarian(225;0.024)|Lung NSC(167;0.0402)|all_lung(232;0.0486)		Epithelial(69;4.07e-14)|COAD - Colon adenocarcinoma(37;0.00986)		ATGTCATTCTGAATTTTGAAA	0.368000														17			27		0	0	0.007291	0	0
TBC1D5	9779	broad.mit.edu	37	3	17300025	17300025	+	Missense_Mutation	SNP	C	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr3:17300025C>A	uc010hev.3	-	16	1568	c.1304G>T	c.(1303-1305)cGa>cTa	p.R435L	TBC1D5_uc010heu.3_Missense_Mutation_p.R22L|TBC1D5_uc003cbf.3_Missense_Mutation_p.R435L|TBC1D5_uc003cbe.3_Missense_Mutation_p.R435L|TBC1D5_uc010hew.1_Missense_Mutation_p.R387L	NM_001134381	NP_001127853	Q92609	TBCD5_HUMAN	Homo sapiens TBC1 domain family, member 5 (TBC1D5), transcript variant 1, mRNA.	435						intracellular	Rab GTPase activator activity|protein binding			NS(1)|breast(1)|endometrium(1)|kidney(3)|large_intestine(7)|lung(14)|ovary(2)|skin(2)|upper_aerodigestive_tract(3)|urinary_tract(2)	36						GTCTGCTCCTCGTGCTTTGTA	0.313000														155			4		0.00198382	0.00219945	0.001984	1	0
VAMP3	9341	broad.mit.edu	37	1	7838212	7838214	+	In_Frame_Del	DEL	TCA	-	-			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr1:7838212_7838214delTCA	uc001aol.3	+	3	381_383	c.266_268delTCA	c.(265-270)ttcatc>ttc	p.I94del		NM_004781	NP_004772	Q15836	VAMP3_HUMAN	Homo sapiens vesicle-associated membrane protein 3 (cellubrevin) (VAMP3), mRNA.	94					cellular membrane fusion|positive regulation of receptor recycling|protein complex assembly|protein transport|retrograde transport, endosome to Golgi|substrate adhesion-dependent cell spreading|vesicle docking involved in exocytosis	cell junction|clathrin-coated vesicle|integral to membrane|recycling endosome|synapse|synaptosome	protein binding			breast(1)|endometrium(1)|haematopoietic_and_lymphoid_tissue(1)|large_intestine(3)	6	Ovarian(185;0.0634)|all_lung(157;0.178)	all_epithelial(116;9.35e-21)|all_lung(118;7.57e-07)|Lung NSC(185;4.52e-06)|Renal(390;0.000147)|Breast(487;0.00086)|Colorectal(325;0.000959)|Hepatocellular(190;0.00825)|Ovarian(437;0.0253)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|all cancers(8;6.33e-69)|GBM - Glioblastoma multiforme(8;2.07e-34)|Colorectal(212;1.36e-07)|COAD - Colon adenocarcinoma(227;1.38e-05)|Kidney(185;4.89e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000805)|KIRC - Kidney renal clear cell carcinoma(229;0.000917)|STAD - Stomach adenocarcinoma(132;0.000985)|READ - Rectum adenocarcinoma(331;0.0642)		CTGGTTATCTTCATCATCATCAT	0.365													---	500	---	---	9	---					
AFF4	27125	broad.mit.edu	37	5	132224853	132224853	+	Frame_Shift_Del	DEL	T	-	-			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr5:132224853delT	uc003kyd.3	-	13	3058	c.2650delA	c.(2650-2652)agtfs	p.S884fs	AFF4_uc011cxk.2_Frame_Shift_Del_p.S562fs	NM_014423	NP_055238	Q9UHB7	AFF4_HUMAN	Homo sapiens AF4/FMR2 family, member 4 (AFF4), mRNA.	884	Ser-rich.				transcription from RNA polymerase II promoter	mitochondrion|nucleolus	protein binding|sequence-specific DNA binding transcription factor activity		SEPT8/AFF4(2)	breast(2)|central_nervous_system(2)|endometrium(6)|kidney(6)|large_intestine(7)|lung(11)|ovary(3)|pancreas(1)|prostate(3)|skin(2)	43		all_cancers(142;0.145)|Breast(839;0.198)	KIRC - Kidney renal clear cell carcinoma(527;0.0186)|Kidney(363;0.0365)			GAGGAGCTACTTGGAGCCTTT	0.373													---	86	---	---	30	---					
NUP188	23511	broad.mit.edu	37	9	131730827	131730828	+	Frame_Shift_Ins	INS	-	A	A			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr9:131730827_131730828insA	uc004bws.1	+	8	650_651	c.628_629insA	c.(628-630)gaafs	p.E210fs		NM_015354	NP_056169	Q5SRE5	NU188_HUMAN	Homo sapiens nucleoporin 188kDa (NUP188), mRNA.	210					carbohydrate metabolic process|glucose transport|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	nuclear pore	protein binding			breast(2)|central_nervous_system(3)|endometrium(6)|kidney(4)|large_intestine(9)|lung(20)|ovary(6)|prostate(4)|skin(2)|upper_aerodigestive_tract(1)|urinary_tract(3)	60						GTGCCTTCGGGAACAGTCCATG	0.391													---	63	---	---	35	---					
MAP3K9	4293	broad.mit.edu	37	14	71275762	71275764	+	In_Frame_Del	DEL	CCG	-	-	rs66483442		TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr14:71275762_71275764delCCG	uc001xmm.3	-	0	125_127	c.125_127delCGG	c.(124-129)gcggtg>gtg	p.A42del	MAP3K9_uc001xml.3_In_Frame_Del_p.A42del	NM_033141	NP_149132	P80192	M3K9_HUMAN	Homo sapiens mitogen-activated protein kinase kinase kinase 9 (MAP3K9), mRNA.	42	Ala-rich.				activation of JUN kinase activity|protein autophosphorylation		ATP binding|JUN kinase kinase kinase activity|MAP kinase kinase activity|protein homodimerization activity			breast(1)|central_nervous_system(3)|cervix(1)|endometrium(1)|kidney(2)|large_intestine(5)|lung(25)|ovary(2)|prostate(1)|skin(3)|stomach(2)	46				all cancers(60;0.00779)|BRCA - Breast invasive adenocarcinoma(234;0.00884)|OV - Ovarian serous cystadenocarcinoma(108;0.08)		CCGGGGCCCACCGCCGCCGCCGc	0.788													---	6	---	---	3	---					
CD276	80381	broad.mit.edu	37	15	73994688	73994696	+	In_Frame_Del	DEL	TTCAGCCTG	-	-			TCGA-D3-A3MO-06A-11D-A21A-08	TCGA-D3-A3MO-10A-01D-A21A-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	affa4ef4-02ec-40f1-b6a2-739f8bf2afa9	46ee8ba7-ef58-4b4c-913c-9507e7a9d7e2	g.chr15:73994688_73994696delTTCAGCCTG	uc002avv.1	+	2	406_414	c.172_180delTTCAGCCTG	c.(172-180)ttcagcctgdel	p.FSL58del	CD276_uc010bjd.1_5'UTR|CD276_uc002avu.1_In_Frame_Del_p.FSL58del|CD276_uc002avw.1_In_Frame_Del_p.FSL58del|CD276_uc010ulb.1_Intron	NM_001024736	NP_001019907	Q5ZPR3	CD276_HUMAN	Homo sapiens CD276 molecule (CD276), transcript variant 1, mRNA.	58	Ig-like V-type 1.				T cell activation|cell proliferation|immune response|positive regulation of T cell proliferation|positive regulation of interferon-gamma biosynthetic process|regulation of immune response	external side of plasma membrane|integral to membrane	receptor binding			endometrium(3)|lung(5)|ovary(1)|skin(2)|stomach(1)|urinary_tract(1)	13						TGAGCCTGGCTTCAGCCTGGCACAGCTCA	0.641													---	27	---	---	19	---					
