Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
EIF2C1	26523	broad.mit.edu	37	1	36359356	36359356	+	Silent	SNP	C	C	T			TCGA-BR-A44T-01A-32D-A24D-08	TCGA-BR-A44T-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37ce42ea-840a-4163-b78f-c911a0d95839	e741ed6d-93bc-4a36-b2b4-6e9368ef4455	g.chr1:36359356C>T	uc001bzl.2	+	5	807	c.594C>T	c.(592-594)TTC>TTT	p.F198F	EIF2C1_uc001bzk.2_Silent_p.F123F|EIF2C1_uc009vuy.2_5'Flank	NM_012199	NP_036331	Q9UL18	AGO1_HUMAN	eukaryotic translation initiation factor 2C, 1	198					negative regulation of translation involved in gene silencing by miRNA|nuclear-transcribed mRNA catabolic process|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasmic mRNA processing body|cytosol|micro-ribonucleoprotein complex|polysome	protein binding|RNA binding			ovary(2)|skin(1)	3		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0887)				AGGTCTGGTTCGGCTTTCACC	0.632												
ADCY10	55811	broad.mit.edu	37	1	167839531	167839531	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-A44T-01A-32D-A24D-08	TCGA-BR-A44T-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37ce42ea-840a-4163-b78f-c911a0d95839	e741ed6d-93bc-4a36-b2b4-6e9368ef4455	g.chr1:167839531A>G	uc001ger.2	-	14	1878	c.1580T>C	c.(1579-1581)ATG>ACG	p.M527T	ADCY10_uc009wvk.2_Missense_Mutation_p.M435T|ADCY10_uc010plj.1_Missense_Mutation_p.M374T|ADCY10_uc009wvl.2_Missense_Mutation_p.M526T	NM_018417	NP_060887	Q96PN6	ADCYA_HUMAN	adenylate cyclase 10	527					intracellular signal transduction|spermatogenesis	cytoskeleton|cytosol|perinuclear region of cytoplasm|plasma membrane|soluble fraction	adenylate cyclase activity|ATP binding|magnesium ion binding			central_nervous_system(2)|ovary(1)	3						CTCAATTTTCATAAGTATCTG	0.368												
CCDC3	83643	broad.mit.edu	37	10	12940586	12940586	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A44T-01A-32D-A24D-08	TCGA-BR-A44T-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37ce42ea-840a-4163-b78f-c911a0d95839	e741ed6d-93bc-4a36-b2b4-6e9368ef4455	g.chr10:12940586G>A	uc001ilq.1	-	3	777	c.643C>T	c.(643-645)CGG>TGG	p.R215W	CCDC3_uc009xjb.1_RNA|CCDC3_uc001ilr.2_RNA|CCDC3_uc009xjc.1_RNA	NM_031455	NP_113643	Q9BQI4	CCDC3_HUMAN	coiled-coil domain containing 3 precursor	215	Potential.					endoplasmic reticulum|extracellular region				ovary(1)	1		Ovarian(717;0.0822)	BRCA - Breast invasive adenocarcinoma(52;0.163)			CGGAGCTGCCGGTTGCGCTTC	0.602												
LYZL1	84569	broad.mit.edu	37	10	29581519	29581519	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A44T-01A-32D-A24D-08	TCGA-BR-A44T-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37ce42ea-840a-4163-b78f-c911a0d95839	e741ed6d-93bc-4a36-b2b4-6e9368ef4455	g.chr10:29581519G>A	uc001iul.2	+	3	406	c.349G>A	c.(349-351)GAC>AAC	p.D117N		NM_032517	NP_115906	Q6UWQ5	LYZL1_HUMAN	lysozyme-like 1	71		By similarity.			cell wall macromolecule catabolic process	extracellular region	lysozyme activity				0		Breast(68;0.203)				CGGCAGCATCGACTATGGCAT	0.577												
PCDH15	65217	broad.mit.edu	37	10	55780164	55780164	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-A44T-01A-32D-A24D-08	TCGA-BR-A44T-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37ce42ea-840a-4163-b78f-c911a0d95839	e741ed6d-93bc-4a36-b2b4-6e9368ef4455	g.chr10:55780164C>A	uc001jju.1	-	20	2934	c.2539G>T	c.(2539-2541)GAC>TAC	p.D847Y	PCDH15_uc010qhq.1_Missense_Mutation_p.D852Y|PCDH15_uc010qhr.1_Missense_Mutation_p.D847Y|PCDH15_uc010qhs.1_Missense_Mutation_p.D859Y|PCDH15_uc010qht.1_Missense_Mutation_p.D854Y|PCDH15_uc010qhu.1_Missense_Mutation_p.D847Y|PCDH15_uc001jjv.1_Intron|PCDH15_uc010qhv.1_Missense_Mutation_p.D847Y|PCDH15_uc010qhw.1_Missense_Mutation_p.D810Y|PCDH15_uc010qhx.1_Missense_Mutation_p.D776Y|PCDH15_uc010qhy.1_Missense_Mutation_p.D852Y|PCDH15_uc010qhz.1_Missense_Mutation_p.D847Y|PCDH15_uc010qia.1_Missense_Mutation_p.D825Y|PCDH15_uc010qib.1_Missense_Mutation_p.D825Y|PCDH15_uc001jjw.2_Missense_Mutation_p.D847Y	NM_033056	NP_149045	Q96QU1	PCD15_HUMAN	protocadherin 15 isoform CD1-4 precursor	847	Extracellular (Potential).|Cadherin 8.				equilibrioception|homophilic cell adhesion|photoreceptor cell maintenance|sensory perception of sound	extracellular region|extracellular space|integral to membrane|photoreceptor outer segment|plasma membrane|stereocilium|synapse	calcium ion binding			pancreas(5)|ovary(4)|upper_aerodigestive_tract(2)|skin(2)	13		Melanoma(3;0.117)|Lung SC(717;0.238)				GCTCCAAGGTCGACATCTTTG	0.403										HNSCC(58;0.16)		
ZNF365	22891	broad.mit.edu	37	10	64159467	64159467	+	Silent	SNP	G	G	A			TCGA-BR-A44T-01A-32D-A24D-08	TCGA-BR-A44T-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37ce42ea-840a-4163-b78f-c911a0d95839	e741ed6d-93bc-4a36-b2b4-6e9368ef4455	g.chr10:64159467G>A	uc001jly.3	+	5	1250	c.1188G>A	c.(1186-1188)GAG>GAA	p.E396E	ZNF365_uc001jmb.3_Intron|ZNF365_uc001jmc.2_Intron|ZNF365_uc001jlz.3_Silent_p.E381E|ZNF365_uc001jma.3_RNA	NM_014951	NP_055766	Q70YC4	TALAN_HUMAN	zinc finger protein 365 isoform A	Error:Variant_position_missing_in_Q70YC4_after_alignment										ovary(1)|skin(1)	2	Prostate(12;0.0297)|all_hematologic(501;0.228)					AGAAAGGGGAGCTCCTGGGGT	0.527												
JMJD1C	221037	broad.mit.edu	37	10	64968251	64968251	+	Missense_Mutation	SNP	T	T	C	rs149833441	by1000genomes	TCGA-BR-A44T-01A-32D-A24D-08	TCGA-BR-A44T-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37ce42ea-840a-4163-b78f-c911a0d95839	e741ed6d-93bc-4a36-b2b4-6e9368ef4455	g.chr10:64968251T>C	uc001jmn.2	-	10	3478	c.3178A>G	c.(3178-3180)AAA>GAA	p.K1060E	JMJD1C_uc001jml.2_Missense_Mutation_p.K841E|JMJD1C_uc001jmm.2_Missense_Mutation_p.K772E|JMJD1C_uc010qiq.1_Missense_Mutation_p.K878E|JMJD1C_uc009xpi.2_Missense_Mutation_p.K878E|JMJD1C_uc009xpj.1_RNA|JMJD1C_uc009xpk.1_Missense_Mutation_p.K97E	NM_032776	NP_116165	Q15652	JHD2C_HUMAN	jumonji domain containing 1C isoform a	1060					blood coagulation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleoplasm	histone demethylase activity (H3-K9 specific)|metal ion binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|thyroid hormone receptor binding			ovary(4)|breast(1)|central_nervous_system(1)	6	Prostate(12;0.0119)|all_hematologic(501;0.191)					ATATGGCTTTTAGGACTGGAA	0.388												
DNMBP	23268	broad.mit.edu	37	10	101716054	101716054	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A44T-01A-32D-A24D-08	TCGA-BR-A44T-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37ce42ea-840a-4163-b78f-c911a0d95839	e741ed6d-93bc-4a36-b2b4-6e9368ef4455	g.chr10:101716054C>T	uc001kqj.2	-	4	1269	c.1177G>A	c.(1177-1179)GAA>AAA	p.E393K	NCRNA00093_uc001kqk.1_Intron	NM_015221	NP_056036	Q6XZF7	DNMBP_HUMAN	dynamin binding protein	393					intracellular signal transduction|regulation of Rho protein signal transduction	cell junction|cytoskeleton|Golgi stack|synapse	protein binding|Rho guanyl-nucleotide exchange factor activity			ovary(5)|skin(1)	6		Colorectal(252;0.234)		Epithelial(162;2.94e-10)|all cancers(201;3.15e-08)		AGAGGCATTTCCCACTCCACG	0.537												
ZFYVE26	23503	broad.mit.edu	37	14	68222803	68222803	+	Silent	SNP	C	C	T			TCGA-BR-A44T-01A-32D-A24D-08	TCGA-BR-A44T-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37ce42ea-840a-4163-b78f-c911a0d95839	e741ed6d-93bc-4a36-b2b4-6e9368ef4455	g.chr14:68222803C>T	uc001xka.2	-	36	6787	c.6648G>A	c.(6646-6648)AAG>AAA	p.K2216K	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkb.2_Silent_p.K62K	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	2216					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding			ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		AAGTGTGTAGCTTCCCACTTT	0.463												
CDH1	999	broad.mit.edu	37	16	68844154	68844154	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-A44T-01A-32D-A24D-08	TCGA-BR-A44T-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37ce42ea-840a-4163-b78f-c911a0d95839	e741ed6d-93bc-4a36-b2b4-6e9368ef4455	g.chr16:68844154A>T	uc002ewg.1	+	6	866	c.742A>T	c.(742-744)ATT>TTT	p.I248F	CDH1_uc010vlj.1_RNA|CDH1_uc010cfg.1_Missense_Mutation_p.I248F	NM_004360	NP_004351	P12830	CADH1_HUMAN	cadherin 1, type 1 preproprotein	248	Cadherin 1.|Extracellular (Potential).				adherens junction organization|cellular component disassembly involved in apoptosis|cellular response to indole-3-methanol|cellular response to lithium ion|homophilic cell adhesion|negative regulation of cell-cell adhesion|positive regulation of transcription factor import into nucleus|positive regulation of transcription, DNA-dependent|regulation of immune response	actin cytoskeleton|aggresome|apical junction complex|catenin complex|cell-cell adherens junction|endosome|focal adhesion|Golgi apparatus|integral to membrane|internal side of plasma membrane|lateral plasma membrane|perinuclear region of cytoplasm	cell adhesion molecule binding|gamma-catenin binding	p.?(2)		breast(148)|stomach(71)|biliary_tract(8)|endometrium(3)|soft_tissue(2)|large_intestine(2)|urinary_tract(2)|oesophagus(2)|ovary(2)|thyroid(1)|central_nervous_system(1)|lung(1)	243		all_neural(199;0.0189)|Ovarian(137;0.0563)		Epithelial(162;8.44e-05)|all cancers(182;0.000404)|OV - Ovarian serous cystadenocarcinoma(108;0.000426)|BRCA - Breast invasive adenocarcinoma(181;0.0261)		TCCAATGGAGATTTTGATCAC	0.483			Mis|N|F|S		lobular breast|gastric	gastric			Hereditary_Diffuse_Gastric_Cancer			
LRRC8E	80131	broad.mit.edu	37	19	7965138	7965138	+	Silent	SNP	C	C	T			TCGA-BR-A44T-01A-32D-A24D-08	TCGA-BR-A44T-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37ce42ea-840a-4163-b78f-c911a0d95839	e741ed6d-93bc-4a36-b2b4-6e9368ef4455	g.chr19:7965138C>T	uc002mir.2	+	3	1832	c.1731C>T	c.(1729-1731)AGC>AGT	p.S577S		NM_025061	NP_079337	Q6NSJ5	LRC8E_HUMAN	leucine rich repeat containing 8 family, member	577	LRR 3.					integral to membrane				lung(1)|pancreas(1)	2						CCCTGAACAGCCTCAAGAAGC	0.662												
ICAM5	7087	broad.mit.edu	37	19	10403881	10403881	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-A44T-01A-32D-A24D-08	TCGA-BR-A44T-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37ce42ea-840a-4163-b78f-c911a0d95839	e741ed6d-93bc-4a36-b2b4-6e9368ef4455	g.chr19:10403881A>T	uc002mnu.3	+	6	1489	c.1424A>T	c.(1423-1425)GAT>GTT	p.D475V	ICAM5_uc002mnv.3_Missense_Mutation_p.D350V	NM_003259	NP_003250	Q9UMF0	ICAM5_HUMAN	intercellular adhesion molecule 5 precursor	475	Extracellular (Potential).|Ig-like C2-type 5.				cell-cell adhesion	integral to plasma membrane				breast(3)	3			OV - Ovarian serous cystadenocarcinoma(20;2.64e-09)|Epithelial(33;4.31e-06)|all cancers(31;9.75e-06)			GCGGCCAATGATCAAGGCGAG	0.652												
ZNF536	9745	broad.mit.edu	37	19	31039733	31039733	+	Silent	SNP	C	C	A			TCGA-BR-A44T-01A-32D-A24D-08	TCGA-BR-A44T-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37ce42ea-840a-4163-b78f-c911a0d95839	e741ed6d-93bc-4a36-b2b4-6e9368ef4455	g.chr19:31039733C>A	uc002nsu.1	+	4	3345	c.3207C>A	c.(3205-3207)ATC>ATA	p.I1069I	ZNF536_uc010edd.1_Silent_p.I1069I	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	1069					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					CCAATATGATCAGCTCTCTAG	0.567												
EGLN2	112398	broad.mit.edu	37	19	41292793	41292793	+	Translation_Start_Site	SNP	C	C	T	rs138702952		TCGA-BR-A44T-01A-32D-A24D-08	TCGA-BR-A44T-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37ce42ea-840a-4163-b78f-c911a0d95839	e741ed6d-93bc-4a36-b2b4-6e9368ef4455	g.chr19:41292793C>T	uc010ehd.2	+	7	677	c.-324C>T	c.(-326--322)TACGG>TATGG		RAB4B_uc002opc.1_RNA|RAB4B_uc002opd.1_Silent_p.Y189Y|RAB4B_uc002ope.1_RNA|RAB4B_uc002opf.1_Silent_p.Y215Y	NM_080732	NP_542770	Q96KS0	EGLN2_HUMAN	EGL nine (C.elegans) homolog 2						cell redox homeostasis|estrogen receptor signaling pathway|positive regulation of protein catabolic process|regulation of cell growth|response to hypoxia	cytoplasm|nucleus	ferrous iron binding|L-ascorbic acid binding|oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|oxygen sensor activity			ovary(2)	2			LUSC - Lung squamous cell carcinoma(20;0.000219)|Lung(22;0.000959)		Vitamin C(DB00126)	GCATTCAGTACGGGGATGCGT	0.682												
DYSF	8291	broad.mit.edu	37	2	71797446	71797446	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A44T-01A-32D-A24D-08	TCGA-BR-A44T-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37ce42ea-840a-4163-b78f-c911a0d95839	e741ed6d-93bc-4a36-b2b4-6e9368ef4455	g.chr2:71797446C>T	uc002sie.2	+	28	3389	c.3013C>T	c.(3013-3015)CGG>TGG	p.R1005W	DYSF_uc010feg.2_Missense_Mutation_p.R1036W|DYSF_uc010feh.2_Missense_Mutation_p.R991W|DYSF_uc002sig.3_Missense_Mutation_p.R991W|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.R1005W|DYSF_uc010fef.2_Missense_Mutation_p.R1022W|DYSF_uc010fei.2_Missense_Mutation_p.R1022W|DYSF_uc010fek.2_Missense_Mutation_p.R1023W|DYSF_uc010fej.2_Missense_Mutation_p.R992W|DYSF_uc010fel.2_Missense_Mutation_p.R992W|DYSF_uc010feo.2_Missense_Mutation_p.R1037W|DYSF_uc010fem.2_Missense_Mutation_p.R1006W|DYSF_uc010fen.2_Missense_Mutation_p.R1023W|DYSF_uc002sif.2_Missense_Mutation_p.R1006W	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	1005	Cytoplasmic (Potential).					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						AGACCTCAACCGGGCTGTCGA	0.592												
RMND5A	64795	broad.mit.edu	37	2	86998770	86998770	+	Silent	SNP	C	C	T			TCGA-BR-A44T-01A-32D-A24D-08	TCGA-BR-A44T-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37ce42ea-840a-4163-b78f-c911a0d95839	e741ed6d-93bc-4a36-b2b4-6e9368ef4455	g.chr2:86998770C>T	uc010ytm.1	+	8	1424	c.1047C>T	c.(1045-1047)CCC>CCT	p.P349P	RMND5A_uc002srs.3_Intron|RMND5A_uc002srr.2_Silent_p.P349P	NM_022780	NP_073617	Q9H871	RMD5A_HUMAN	required for meiotic nuclear division 5 homolog	349										ovary(1)|skin(1)	2						ACAATCCACCCATGAAATTGG	0.353												
DUSP18	150290	broad.mit.edu	37	22	31059889	31059889	+	Silent	SNP	G	G	A			TCGA-BR-A44T-01A-32D-A24D-08	TCGA-BR-A44T-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37ce42ea-840a-4163-b78f-c911a0d95839	e741ed6d-93bc-4a36-b2b4-6e9368ef4455	g.chr22:31059889G>A	uc003aiu.2	-	2	603	c.102C>T	c.(100-102)GCC>GCT	p.A34A	SLC35E4_uc003ait.2_Intron|DUSP18_uc010gwa.1_RNA|DUSP18_uc003aiw.1_Silent_p.A34A	NM_152511	NP_689724	Q8NEJ0	DUS18_HUMAN	dual specificity phosphatase 18	34						cytoplasm|nucleus	MAP kinase tyrosine/serine/threonine phosphatase activity|protein tyrosine phosphatase activity				0						TGTTGTTGGCGGCCACACCAT	0.522												
CEP63	80254	broad.mit.edu	37	3	134256014	134256014	+	Silent	SNP	G	G	A			TCGA-BR-A44T-01A-32D-A24D-08	TCGA-BR-A44T-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37ce42ea-840a-4163-b78f-c911a0d95839	e741ed6d-93bc-4a36-b2b4-6e9368ef4455	g.chr3:134256014G>A	uc003eqo.1	+	7	908	c.459G>A	c.(457-459)TCG>TCA	p.S153S	CEP63_uc003eql.1_Silent_p.S153S|CEP63_uc003eqm.2_Silent_p.S153S|CEP63_uc003eqn.1_Silent_p.S153S	NM_025180	NP_079456	Q96MT8	CEP63_HUMAN	centrosomal protein 63 isoform a	153	Potential.				cell division|DNA damage checkpoint|G2/M transition of mitotic cell cycle|mitosis|signal transduction in response to DNA damage|spindle assembly	centrosome|cytosol|spindle pole	protein binding			ovary(1)	1						GTCAGAAATCGCTGGACTGGG	0.443												
RFC1	5981	broad.mit.edu	37	4	39310272	39310272	+	Silent	SNP	G	G	A			TCGA-BR-A44T-01A-32D-A24D-08	TCGA-BR-A44T-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37ce42ea-840a-4163-b78f-c911a0d95839	e741ed6d-93bc-4a36-b2b4-6e9368ef4455	g.chr4:39310272G>A	uc003gty.1	-	13	2003	c.1869C>T	c.(1867-1869)TCC>TCT	p.S623S	RFC1_uc003gtx.1_Silent_p.S623S	NM_002913	NP_002904	P35251	RFC1_HUMAN	replication factor C large subunit	623					DNA strand elongation involved in DNA replication|nucleotide-excision repair, DNA gap filling|regulation of transcription, DNA-dependent|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|telomere maintenance via telomerase|transcription, DNA-dependent|transcription-coupled nucleotide-excision repair	DNA replication factor C complex|nucleoplasm	ATP binding|DNA clamp loader activity|enzyme activator activity|protein binding			ovary(2)|pancreas(1)|skin(1)	4						TTTTATCTTCGGAAGAACTCT	0.428												
GABRB1	2560	broad.mit.edu	37	4	47427792	47427792	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A44T-01A-32D-A24D-08	TCGA-BR-A44T-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37ce42ea-840a-4163-b78f-c911a0d95839	e741ed6d-93bc-4a36-b2b4-6e9368ef4455	g.chr4:47427792G>A	uc003gxh.2	+	9	1556	c.1182G>A	c.(1180-1182)ATG>ATA	p.M394I	GABRB1_uc011bze.1_Missense_Mutation_p.M324I	NM_000812	NP_000803	P18505	GBRB1_HUMAN	gamma-aminobutyric acid (GABA) A receptor, beta	394	Cytoplasmic (Probable).				synaptic transmission	cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(2)	2					Ethchlorvynol(DB00189)|Flurazepam(DB00690)|Lorazepam(DB00186)|Midazolam(DB00683)	AGGCCACCATGTACTCCTATG	0.652												
PCDHB3	56132	broad.mit.edu	37	5	140482357	140482357	+	Silent	SNP	C	C	T			TCGA-BR-A44T-01A-32D-A24D-08	TCGA-BR-A44T-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37ce42ea-840a-4163-b78f-c911a0d95839	e741ed6d-93bc-4a36-b2b4-6e9368ef4455	g.chr5:140482357C>T	uc003lio.2	+	1	2124	c.2124C>T	c.(2122-2124)TTC>TTT	p.F708F	uc003lin.2_5'Flank	NM_018937	NP_061760	Q9Y5E6	PCDB3_HUMAN	protocadherin beta 3 precursor	708	Helical; (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to plasma membrane	calcium ion binding			ovary(1)|pancreas(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			TGCTCCTGTTCGTGGCGGTGC	0.687												
FAT2	2196	broad.mit.edu	37	5	150901071	150901071	+	Missense_Mutation	SNP	C	C	T	rs61743252		TCGA-BR-A44T-01A-32D-A24D-08	TCGA-BR-A44T-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37ce42ea-840a-4163-b78f-c911a0d95839	e741ed6d-93bc-4a36-b2b4-6e9368ef4455	g.chr5:150901071C>T	uc003lue.3	-	18	11096	c.11083G>A	c.(11083-11085)GAG>AAG	p.E3695K	GM2A_uc011dcs.1_Intron|FAT2_uc003lud.3_Missense_Mutation_p.E388K	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	3695	Extracellular (Potential).				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			TCCTGAAACTCGTAGAAGGTT	0.567												
IRF4	3662	broad.mit.edu	37	6	398916	398916	+	Silent	SNP	C	C	T			TCGA-BR-A44T-01A-32D-A24D-08	TCGA-BR-A44T-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37ce42ea-840a-4163-b78f-c911a0d95839	e741ed6d-93bc-4a36-b2b4-6e9368ef4455	g.chr6:398916C>T	uc003msz.3	+	6	839	c.726C>T	c.(724-726)GCC>GCT	p.A242A	IRF4_uc010jne.1_Silent_p.A242A|IRF4_uc003mta.3_RNA|IRF4_uc003mtb.3_Silent_p.A241A|IRF4_uc003mtc.1_Silent_p.A72A	NM_002460	NP_002451	Q15306	IRF4_HUMAN	interferon regulatory factor 4	242					interferon-gamma-mediated signaling pathway|positive regulation of interleukin-10 biosynthetic process|positive regulation of interleukin-13 biosynthetic process|positive regulation of interleukin-2 biosynthetic process|positive regulation of interleukin-4 biosynthetic process|positive regulation of transcription, DNA-dependent|regulation of T-helper cell differentiation|T cell activation|type I interferon-mediated signaling pathway	cytoplasm	DNA binding|sequence-specific DNA binding transcription factor activity|transcription factor binding			ovary(1)	1		Breast(5;0.0155)|all_lung(73;0.0691)|all_hematologic(90;0.0895)		OV - Ovarian serous cystadenocarcinoma(45;0.03)|BRCA - Breast invasive adenocarcinoma(62;0.0702)		TAAGGTCTGCCGAAGCCTTGG	0.587			T	IGH@	MM 							
RFX6	222546	broad.mit.edu	37	6	117246619	117246619	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A44T-01A-32D-A24D-08	TCGA-BR-A44T-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37ce42ea-840a-4163-b78f-c911a0d95839	e741ed6d-93bc-4a36-b2b4-6e9368ef4455	g.chr6:117246619C>T	uc003pxm.2	+	16	1745	c.1682C>T	c.(1681-1683)GCG>GTG	p.A561V		NM_173560	NP_775831	Q8HWS3	RFX6_HUMAN	regulatory factor X, 6	561					glucose homeostasis|pancreatic A cell differentiation|pancreatic D cell differentiation|pancreatic E cell differentiation|positive regulation of transcription, DNA-dependent|regulation of insulin secretion|transcription, DNA-dependent|type B pancreatic cell differentiation	nucleus	protein binding|transcription regulatory region DNA binding			ovary(1)|pancreas(1)|skin(1)	3						TTTCCAGATGCGAGTAAAGCT	0.393												
TBP	6908	broad.mit.edu	37	6	170873698	170873698	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A44T-01A-32D-A24D-08	TCGA-BR-A44T-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37ce42ea-840a-4163-b78f-c911a0d95839	e741ed6d-93bc-4a36-b2b4-6e9368ef4455	g.chr6:170873698G>A	uc003qxt.2	+	4	795	c.563G>A	c.(562-564)CGA>CAA	p.R188Q	TBP_uc003qxu.2_Missense_Mutation_p.R188Q|TBP_uc011ehf.1_Missense_Mutation_p.R168Q	NM_003194	NP_003185	P20226	TBP_HUMAN	TATA box binding protein	188	1.				cell death|interspecies interaction between organisms|transcription elongation from RNA polymerase II promoter|transcription from RNA polymerase III promoter|viral reproduction	transcription factor TFIIA complex|transcription factor TFIID complex	repressing transcription factor binding|transcription regulatory region DNA binding			ovary(1)	1		Breast(66;5.08e-05)|Ovarian(120;0.125)|Esophageal squamous(34;0.246)		OV - Ovarian serous cystadenocarcinoma(33;1.07e-22)|BRCA - Breast invasive adenocarcinoma(81;5.01e-06)|GBM - Glioblastoma multiforme(31;0.00591)		CTTCGTGCCCGAAACGCCGAA	0.323												
TMEM168	64418	broad.mit.edu	37	7	112424364	112424364	+	Silent	SNP	A	A	G			TCGA-BR-A44T-01A-32D-A24D-08	TCGA-BR-A44T-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37ce42ea-840a-4163-b78f-c911a0d95839	e741ed6d-93bc-4a36-b2b4-6e9368ef4455	g.chr7:112424364A>G	uc003vgn.2	-	2	909	c.517T>C	c.(517-519)TTG>CTG	p.L173L	TMEM168_uc010lju.2_Silent_p.L173L|TMEM168_uc011kmr.1_Intron	NM_022484	NP_071929	Q9H0V1	TM168_HUMAN	transmembrane protein 168	173	Helical; (Potential).					integral to membrane|transport vesicle				ovary(1)|central_nervous_system(1)	2						TTCTCCACCAACATAGTTGTG	0.418												
AASS	10157	broad.mit.edu	37	7	121717920	121717920	+	Silent	SNP	G	G	A			TCGA-BR-A44T-01A-32D-A24D-08	TCGA-BR-A44T-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37ce42ea-840a-4163-b78f-c911a0d95839	e741ed6d-93bc-4a36-b2b4-6e9368ef4455	g.chr7:121717920G>A	uc003vka.2	-	22	2730	c.2634C>T	c.(2632-2634)ACC>ACT	p.T878T	AASS_uc011knu.1_RNA|AASS_uc011knv.1_RNA|AASS_uc003vkb.2_Silent_p.T878T|AASS_uc011knw.1_Silent_p.T366T	NM_005763	NP_005754	Q9UDR5	AASS_HUMAN	aminoadipate-semialdehyde synthase precursor	878	Saccharopine dehydrogenase.				protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			upper_aerodigestive_tract(1)|ovary(1)	2					L-Glutamic Acid(DB00142)|NADH(DB00157)	CTGCCATGGCGGTGGGTAACC	0.463												
MSL3	10943	broad.mit.edu	37	X	11780981	11780981	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-A44T-01A-32D-A24D-08	TCGA-BR-A44T-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37ce42ea-840a-4163-b78f-c911a0d95839	e741ed6d-93bc-4a36-b2b4-6e9368ef4455	g.chrX:11780981A>G	uc004cuw.2	+	7	719	c.614A>G	c.(613-615)AAC>AGC	p.N205S	MSL3_uc004cuv.1_Missense_Mutation_p.N205S|MSL3_uc004cux.2_Missense_Mutation_p.N146S|MSL3_uc011mig.1_Missense_Mutation_p.N56S|MSL3_uc011mih.1_Missense_Mutation_p.N193S|MSL3_uc004cuy.2_Missense_Mutation_p.N39S|MSL3_uc011mii.1_Missense_Mutation_p.N39S	NM_078629	NP_523353	Q8N5Y2	MS3L1_HUMAN	male-specific lethal 3-like 1 isoform a	205					histone H4-K16 acetylation|multicellular organismal development|transcription from RNA polymerase II promoter	MSL complex	DNA binding|methylated histone residue binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1						TGCCAGACCAACATCATAACG	0.408												
SHROOM4	57477	broad.mit.edu	37	X	50376561	50376561	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-A44T-01A-32D-A24D-08	TCGA-BR-A44T-10A-01D-A24F-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	37ce42ea-840a-4163-b78f-c911a0d95839	e741ed6d-93bc-4a36-b2b4-6e9368ef4455	g.chrX:50376561G>T	uc004dpe.2	-	4	2538	c.2512C>A	c.(2512-2514)CAT>AAT	p.H838N	SHROOM4_uc004dpd.3_RNA|SHROOM4_uc004dpf.1_Missense_Mutation_p.H722N	NM_020717	NP_065768	Q9ULL8	SHRM4_HUMAN	shroom family member 4	838					actin filament organization|brain development|cell morphogenesis|cognition	apical plasma membrane|basal plasma membrane|internal side of plasma membrane|nucleus	actin filament binding			upper_aerodigestive_tract(1)	1	Ovarian(276;0.236)					TCTGTGGCATGATATGGTTGG	0.448												
