Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values
PRDM16	63976	broad.mit.edu	37	1	3319370	3319370	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr1:3319370G>A	uc001akf.2	+	6	772	c.692G>A	c.(691-693)CGC>CAC	p.R231H	PRDM16_uc001akc.2_Missense_Mutation_p.R231H|PRDM16_uc001akd.2_Missense_Mutation_p.R231H|PRDM16_uc001ake.2_Missense_Mutation_p.R231H|PRDM16_uc009vlh.2_5'UTR	NM_022114	NP_071397	Q9HAZ2	PRD16_HUMAN	PR domain containing 16 isoform 1	231	C2H2-type 1; atypical.				brown fat cell differentiation|negative regulation of granulocyte differentiation|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transforming growth factor beta receptor signaling pathway|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|regulation of cellular respiration|transcription, DNA-dependent	transcriptional repressor complex	protein binding|sequence-specific DNA binding|transcription coactivator activity|zinc ion binding			lung(3)|ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	7	all_cancers(77;0.00208)|all_epithelial(69;0.000732)|Ovarian(185;0.0634)|Lung NSC(156;0.109)|all_lung(157;0.111)	all_epithelial(116;2.03e-21)|all_lung(118;7.55e-09)|Lung NSC(185;1.28e-06)|Breast(487;0.000792)|Renal(390;0.00137)|Hepatocellular(190;0.00515)|Myeloproliferative disorder(586;0.0267)|Ovarian(437;0.0365)|Lung SC(97;0.114)|Medulloblastoma(700;0.134)		Epithelial(90;5.59e-35)|OV - Ovarian serous cystadenocarcinoma(86;1.99e-20)|GBM - Glioblastoma multiforme(42;3.72e-11)|Colorectal(212;0.000425)|BRCA - Breast invasive adenocarcinoma(365;0.000946)|COAD - Colon adenocarcinoma(227;0.000968)|Kidney(185;0.00155)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0175)|Lung(427;0.137)		CCCACGTTCCGCTGTGACGAG	0.627			T	EVI1	MDS|AML							
HIST2H2BF	440689	broad.mit.edu	37	1	149783796	149783796	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr1:149783796T>C	uc001esr.2	-	1	133	c.83A>G	c.(82-84)AAG>AGG	p.K28R	HIST2H2BF_uc010pbj.1_Missense_Mutation_p.K28R|HIST2H2BF_uc010pbk.1_Missense_Mutation_p.K28R	NM_001024599	NP_001019770	Q5QNW6	H2B2F_HUMAN	histone cluster 2, H2bf isoform a	28					nucleosome assembly	nucleosome|nucleus	DNA binding				0	Breast(34;0.0124)|all_hematologic(923;0.127)					CTTGCGCTTCTTGCCGTCCTT	0.567												
TDRKH	11022	broad.mit.edu	37	1	151748570	151748570	+	Splice_Site	SNP	A	A	T			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr1:151748570A>T	uc009wnb.1	-	8	1399	c.1217_splice	c.e8+1	p.R406_splice	TDRKH_uc001eyy.2_Splice_Site_p.R182_splice|TDRKH_uc001ezb.3_Splice_Site_p.R402_splice|TDRKH_uc001ezc.3_Splice_Site_p.R361_splice|TDRKH_uc001eza.3_Splice_Site_p.R406_splice|TDRKH_uc001ezd.3_Splice_Site_p.R406_splice|TDRKH_uc010pdn.1_Splice_Site_p.R182_splice	NM_006862	NP_006853	Q9Y2W6	TDRKH_HUMAN	tudor and KH domain containing isoform a								RNA binding			ovary(1)|pancreas(1)	2	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.14)		LUSC - Lung squamous cell carcinoma(543;0.181)			CTCAGCACTGACCTGAGAGCC	0.532												
FLG	2312	broad.mit.edu	37	1	152276817	152276817	+	Silent	SNP	G	G	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr1:152276817G>A	uc001ezu.1	-	3	10581	c.10545C>T	c.(10543-10545)AGC>AGT	p.S3515S		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	3515	Ser-rich.|Filaggrin 21.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AGTGTCTAGAGCTGTCCGCCT	0.567									Ichthyosis			
HMCN1	83872	broad.mit.edu	37	1	186081953	186081953	+	Nonsense_Mutation	SNP	C	C	T			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr1:186081953C>T	uc001grq.1	+	72	11228	c.10999C>T	c.(10999-11001)CGA>TGA	p.R3667*		NM_031935	NP_114141	Q96RW7	HMCN1_HUMAN	hemicentin 1 precursor	3667	Ig-like C2-type 35.				response to stimulus|visual perception	basement membrane	calcium ion binding			ovary(22)|skin(1)	23						GGCAACACCTCGAGTGCGAAT	0.393												
KCNT2	343450	broad.mit.edu	37	1	196303015	196303015	+	Silent	SNP	A	A	G			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr1:196303015A>G	uc001gtd.1	-	17	2019	c.1959T>C	c.(1957-1959)GAT>GAC	p.D653D	KCNT2_uc009wyt.1_RNA|KCNT2_uc001gte.1_Silent_p.D603D|KCNT2_uc001gtf.1_Silent_p.D653D|KCNT2_uc001gtg.1_RNA|KCNT2_uc009wyu.2_Silent_p.D653D|KCNT2_uc001gth.1_Silent_p.D174D	NM_198503	NP_940905	Q6UVM3	KCNT2_HUMAN	potassium channel, subfamily T, member 2	653	Cytoplasmic (Potential).					voltage-gated potassium channel complex	ATP binding|calcium-activated potassium channel activity|voltage-gated potassium channel activity			ovary(5)|breast(1)|skin(1)	7						GTGTAGTTTCATCTTCTGATT	0.358												
CFHR5	81494	broad.mit.edu	37	1	196953209	196953209	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr1:196953209G>T	uc001gts.3	+	3	500	c.372G>T	c.(370-372)GAG>GAT	p.E124D		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5 precursor	124	Sushi 2.				complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2						AAAACAATGAGAAAAACATTT	0.378												
IL19	29949	broad.mit.edu	37	1	207010359	207010359	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr1:207010359G>T	uc001hep.2	+	4	1140	c.201G>T	c.(199-201)CAG>CAT	p.Q67H	IL19_uc001heo.2_Missense_Mutation_p.Q105H|IL19_uc010prx.1_Missense_Mutation_p.Q67H	NM_013371	NP_037503	Q9UHD0	IL19_HUMAN	interleukin 19 isoform 2 precursor	67					apoptosis|immune response|signal transduction	extracellular space	cytokine activity			ovary(1)|central_nervous_system(1)	2			BRCA - Breast invasive adenocarcinoma(75;0.211)			AGACTCTGCAGATCATTAAGG	0.438												
LAMB3	3914	broad.mit.edu	37	1	209798993	209798993	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr1:209798993C>A	uc001hhg.2	-	13	2366	c.1976G>T	c.(1975-1977)AGG>ATG	p.R659M	LAMB3_uc009xco.2_Missense_Mutation_p.R659M|LAMB3_uc001hhh.2_Missense_Mutation_p.R659M|LAMB3_uc010psl.1_Intron|hsa-mir-4260|MI0015859_5'Flank	NM_001017402	NP_001017402	Q13751	LAMB3_HUMAN	laminin, beta 3 precursor	659	Domain II.				cell adhesion|epidermis development|hemidesmosome assembly		structural molecule activity			central_nervous_system(2)|skin(2)|large_intestine(1)|ovary(1)	6				OV - Ovarian serous cystadenocarcinoma(81;0.0519)		AGGGAATTACCTGAGGGAGAG	0.483												
RBP3	5949	broad.mit.edu	37	10	48387918	48387918	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr10:48387918G>T	uc001jez.2	-	1	3074	c.2960C>A	c.(2959-2961)GCT>GAT	p.A987D		NM_002900	NP_002891	P10745	RET3_HUMAN	retinol-binding protein 3 precursor	987	4 X approximate tandem repeats.|4.				lipid metabolic process|proteolysis|transport|visual perception	interphotoreceptor matrix	retinal binding|serine-type peptidase activity			large_intestine(1)|central_nervous_system(1)	2					Vitamin A(DB00162)	CTGCAGGTCAGCCCCCAGGAT	0.612												
C10orf71	118461	broad.mit.edu	37	10	50530848	50530848	+	Silent	SNP	G	G	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr10:50530848G>A	uc010qgp.1	+	3	597	c.258G>A	c.(256-258)CCG>CCA	p.P86P		NM_199459	NP_955629	Q711Q0	CJ071_HUMAN	hypothetical protein LOC118461 isoform 2	86											0						GCCAGTTACCGTCACAGGGCA	0.572												
COL13A1	1305	broad.mit.edu	37	10	71657242	71657242	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr10:71657242C>A	uc001jpr.1	+	12	1205	c.669C>A	c.(667-669)AGC>AGA	p.S223R	COL13A1_uc001jqj.1_Missense_Mutation_p.S223R|COL13A1_uc001jps.1_Missense_Mutation_p.S194R|COL13A1_uc001jpt.1_Intron|COL13A1_uc001jpu.1_Intron|COL13A1_uc001jpv.1_Missense_Mutation_p.S223R|COL13A1_uc001jpx.1_Missense_Mutation_p.S223R|COL13A1_uc001jpw.1_Intron|COL13A1_uc001jpy.1_Intron|COL13A1_uc001jpz.1_Intron|COL13A1_uc001jqa.1_Missense_Mutation_p.S185R|COL13A1_uc001jqc.1_Missense_Mutation_p.S223R|COL13A1_uc001jqb.1_Missense_Mutation_p.S194R|COL13A1_uc001jql.2_Missense_Mutation_p.S223R|COL13A1_uc001jqd.1_Missense_Mutation_p.S211R|COL13A1_uc001jqe.1_Missense_Mutation_p.S206R|COL13A1_uc001jqf.1_Intron|COL13A1_uc001jqg.1_Missense_Mutation_p.S223R|COL13A1_uc001jqh.1_Missense_Mutation_p.S223R|COL13A1_uc001jqi.1_Missense_Mutation_p.S223R|COL13A1_uc010qjf.1_Intron|COL13A1_uc001jqk.1_Missense_Mutation_p.S83R	NM_005203	NP_005194	Q5TAT6	CODA1_HUMAN	alpha 1 type XIII collagen isoform 1	223	Extracellular (Potential).|Nonhelical region 2 (NC2).				cell differentiation|cell-cell adhesion|cell-matrix adhesion|endochondral ossification|morphogenesis of a branching structure	collagen type XIII|integral to membrane	extracellular matrix structural constituent|heparin binding|protein binding			ovary(1)	1					Atorvastatin(DB01076)|Simvastatin(DB00641)	AGTGCCTAAGCAGCATGCCAG	0.612												
MKI67	4288	broad.mit.edu	37	10	129899811	129899811	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr10:129899811C>T	uc001lke.2	-	14	9611	c.9416G>A	c.(9415-9417)GGA>GAA	p.G3139E	MKI67_uc001lkf.2_Missense_Mutation_p.G2779E	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	3139					cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TTTCCGGGCTCCATCATCTGG	0.458												
TRPM5	29850	broad.mit.edu	37	11	2435394	2435394	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr11:2435394A>G	uc001lwm.3	-	12	1796	c.1787T>C	c.(1786-1788)TTC>TCC	p.F596S	TRPM5_uc010qxl.1_Missense_Mutation_p.F596S|TRPM5_uc009ydn.2_Missense_Mutation_p.F598S	NM_014555	NP_055370	Q9NZQ8	TRPM5_HUMAN	transient receptor potential cation channel,	596	Cytoplasmic (Potential).					integral to membrane|plasma membrane	receptor activity|voltage-gated ion channel activity			ovary(1)|breast(1)|central_nervous_system(1)|skin(1)	4		Medulloblastoma(188;0.0049)|Breast(177;0.00586)|all_epithelial(84;0.0075)|Ovarian(85;0.0256)|all_neural(188;0.0311)		BRCA - Breast invasive adenocarcinoma(625;0.00147)|LUSC - Lung squamous cell carcinoma(625;0.191)		CAGCAGGGCGAAGGCGCGGGC	0.706												
TRIM68	55128	broad.mit.edu	37	11	4622295	4622295	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr11:4622295C>G	uc001lzf.1	-	6	1107	c.869G>C	c.(868-870)CGT>CCT	p.R290P	TRIM68_uc001lzg.1_Missense_Mutation_p.R67P|TRIM68_uc010qyj.1_RNA	NM_018073	NP_060543	Q6AZZ1	TRI68_HUMAN	ring finger protein 137	290	B30.2/SPRY.				protein autoubiquitination|regulation of androgen receptor signaling pathway	Golgi apparatus|nucleolus|perinuclear region of cytoplasm	androgen receptor binding|histone acetyltransferase binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;9.49e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0288)|LUSC - Lung squamous cell carcinoma(625;0.192)		CCCCAGCACACGGCAATCTGT	0.552												
OR51D1	390038	broad.mit.edu	37	11	4661620	4661620	+	Silent	SNP	G	G	T			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr11:4661620G>T	uc010qyk.1	+	1	600	c.600G>T	c.(598-600)CTG>CTT	p.L200L		NM_001004751	NP_001004751	Q8NGF3	O51D1_HUMAN	olfactory receptor, family 51, subfamily D,	200	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;2.74e-13)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|GBM - Glioblastoma multiforme(2;0.0841)|LUSC - Lung squamous cell carcinoma(625;0.19)		TTATGAAGCTGTCCTGTACTG	0.458												
OR51E1	143503	broad.mit.edu	37	11	4673886	4673886	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr11:4673886G>C	uc001lzi.3	+	2	274	c.130G>C	c.(130-132)GGT>CGT	p.G44R		NM_152430	NP_689643	Q8TCB6	O51E1_HUMAN	olfactory receptor, family 51, subfamily E,	43	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			large_intestine(3)|pancreas(1)	4		Medulloblastoma(188;0.0025)|Breast(177;0.0101)|all_neural(188;0.0227)		Epithelial(150;7.37e-14)|GBM - Glioblastoma multiforme(2;2.85e-05)|BRCA - Breast invasive adenocarcinoma(625;0.00222)|LUSC - Lung squamous cell carcinoma(625;0.19)		TGCTGTGCTAGGTAACTTGAC	0.468												
OR52R1	119695	broad.mit.edu	37	11	4824825	4824825	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr11:4824825G>T	uc010qym.1	-	1	1023	c.1023C>A	c.(1021-1023)TTC>TTA	p.F341L		NM_001005177	NP_001005177	Q8NGF1	O52R1_HUMAN	olfactory receptor, family 52, subfamily R,	262	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1		Medulloblastoma(188;0.0025)|Breast(177;0.0184)|all_neural(188;0.0227)		Epithelial(150;4.77e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00435)|LUSC - Lung squamous cell carcinoma(625;0.19)		GGTAGGTGAGGAAAGAAAAAA	0.478												
DCHS1	8642	broad.mit.edu	37	11	6650775	6650775	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr11:6650775G>C	uc001mem.1	-	12	5479	c.5069C>G	c.(5068-5070)TCT>TGT	p.S1690C		NM_003737	NP_003728	Q96JQ0	PCD16_HUMAN	dachsous 1 precursor	1690	Cadherin 16.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|large_intestine(1)|pancreas(1)	5		Medulloblastoma(188;0.00263)|all_neural(188;0.026)		Epithelial(150;6.35e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		GCTTTCGCTAGAGACGCCTCC	0.552												
OR8J3	81168	broad.mit.edu	37	11	55904869	55904869	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr11:55904869A>G	uc010riz.1	-	1	326	c.326T>C	c.(325-327)GTA>GCA	p.V109A		NM_001004064	NP_001004064	Q8NGG0	OR8J3_HUMAN	olfactory receptor, family 8, subfamily J,	109	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(2)	2	Esophageal squamous(21;0.00693)					TACCTCCGATACAATAAAGAA	0.473												
FGF3	2248	broad.mit.edu	37	11	69631105	69631105	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr11:69631105C>T	uc001oph.2	-	2	798	c.307G>A	c.(307-309)GGA>AGA	p.G103R		NM_005247	NP_005238	P11487	FGF3_HUMAN	fibroblast growth factor 3 precursor	103					fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|negative regulation of cardiac muscle tissue development|positive regulation of cell division|positive regulation of cell proliferation	extracellular region	growth factor activity			ovary(1)|lung(1)	2			LUSC - Lung squamous cell carcinoma(11;5.05e-15)|STAD - Stomach adenocarcinoma(18;0.0278)			TAGAGTCGTCCCCTCTTGTTC	0.597												
FUT4	2526	broad.mit.edu	37	11	94278513	94278513	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr11:94278513C>T	uc001pez.2	+	1	1497	c.1214C>T	c.(1213-1215)GCC>GTC	p.A405V	PIWIL4_uc010rue.1_Intron|PIWIL4_uc009ywk.1_5'Flank	NM_002033	NP_002024	P22083	FUT4_HUMAN	fucosyltransferase 4	405	Lumenal (Potential).				L-fucose catabolic process|protein glycosylation	Golgi cisterna membrane|integral to membrane|membrane fraction	alpha(1,3)-fucosyltransferase activity			skin(1)	1		Acute lymphoblastic leukemia(157;2.31e-05)|all_hematologic(158;0.00824)				CACACAGTGGCCCGCTACAAG	0.637												
PIWIL4	143689	broad.mit.edu	37	11	94340624	94340624	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr11:94340624C>A	uc001pfa.2	+	14	1869	c.1658C>A	c.(1657-1659)TCT>TAT	p.S553Y	PIWIL4_uc010rue.1_RNA|PIWIL4_uc009ywk.1_RNA	NM_152431	NP_689644	Q7Z3Z4	PIWL4_HUMAN	piwi-like 4	553	Piwi.				cell differentiation|DNA methylation involved in gamete generation|gene silencing by RNA|meiosis|multicellular organismal development|piRNA metabolic process|regulation of translation|spermatogenesis	nucleus|piP-body	piRNA binding			skin(1)	1		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.0123)				ATTCTGCCTTCTAATCAGAAG	0.363												
DYNC2H1	79659	broad.mit.edu	37	11	103006490	103006490	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr11:103006490G>A	uc001pho.2	+	17	2531	c.2387G>A	c.(2386-2388)CGG>CAG	p.R796Q	DYNC2H1_uc001phn.1_Missense_Mutation_p.R796Q|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	796	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		GAAGAAATCCGGGCTAAATAT	0.318												
CDON	50937	broad.mit.edu	37	11	125891265	125891265	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr11:125891265T>G	uc009zbw.2	-	3	355	c.227A>C	c.(226-228)AAG>ACG	p.K76T	CDON_uc001qdc.3_Missense_Mutation_p.K76T|CDON_uc001qdd.3_RNA|CDON_uc009zbx.2_Missense_Mutation_p.K76T	NM_016952	NP_058648	Q4KMG0	CDON_HUMAN	surface glycoprotein, Ig superfamily member	76	Extracellular (Potential).|Ig-like C2-type 1.				cell adhesion|muscle cell differentiation|positive regulation of muscle cell differentiation	integral to membrane|plasma membrane	protein binding			ovary(3)|skin(2)|breast(1)	6	all_hematologic(175;0.177)	Breast(109;0.00157)|Lung NSC(97;0.0127)|all_lung(97;0.0133)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.51e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0604)		CTGATGAATCTTAACATGTTC	0.468												
FAR2	55711	broad.mit.edu	37	12	29474774	29474774	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr12:29474774G>C	uc001ris.3	+	10	1321	c.1174G>C	c.(1174-1176)GAG>CAG	p.E392Q	FAR2_uc001rit.2_Missense_Mutation_p.E392Q|FAR2_uc009zjm.2_Missense_Mutation_p.E295Q	NM_018099	NP_060569	Q96K12	FACR2_HUMAN	fatty acyl CoA reductase 2	392					ether lipid biosynthetic process	endoplasmic reticulum membrane|integral to membrane|peroxisomal matrix|peroxisomal membrane	binding|oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor				0						TTCCATGTTGGAGTATTTCAT	0.448												
CNTN1	1272	broad.mit.edu	37	12	41337868	41337868	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr12:41337868G>A	uc001rmm.1	+	14	1692	c.1579G>A	c.(1579-1581)GCT>ACT	p.A527T	CNTN1_uc009zjy.1_Missense_Mutation_p.A527T|CNTN1_uc001rmn.1_Missense_Mutation_p.A516T|CNTN1_uc001rmo.2_Missense_Mutation_p.A527T	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	527	Ig-like C2-type 6.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				CATGCAGTGTGCTGCGTCCTT	0.388												
ANKRD52	283373	broad.mit.edu	37	12	56647085	56647085	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr12:56647085C>T	uc001skm.3	-	10	1177	c.1087G>A	c.(1087-1089)GCA>ACA	p.A363T		NM_173595	NP_775866	Q8NB46	ANR52_HUMAN	ankyrin repeat domain 52	363	ANK 11.						protein binding			ovary(2)	2						GCGGTATCTGCGCCATTGGTC	0.572												
GLIPR1L1	256710	broad.mit.edu	37	12	75728626	75728626	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr12:75728626G>A	uc001sxo.2	+	1	164	c.118G>A	c.(118-120)GCC>ACC	p.A40T	CAPS2_uc001sxm.3_Intron|CAPS2_uc009zsa.2_Intron|GLIPR1L1_uc001sxn.2_Missense_Mutation_p.A40T	NM_152779	NP_689992	Q6UWM5	GPRL1_HUMAN	GLI pathogenesis-related 1 like 1	40						extracellular region					0						CTGCATAGAAGCCCACAACGA	0.483											OREG0021998	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)
RAB35	11021	broad.mit.edu	37	12	120535069	120535069	+	Nonsense_Mutation	SNP	G	G	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr12:120535069G>A	uc001txm.1	-	6	731	c.586C>T	c.(586-588)CGA>TGA	p.R196*	RAB35_uc010szg.1_Translation_Start_Site|RAB35_uc009zww.1_Translation_Start_Site|RAB35_uc010szh.1_3'UTR	NM_006861	NP_006852	Q15286	RAB35_HUMAN	RAB35, member RAS oncogene family	196					cytokinesis|endosome transport|protein transport|small GTPase mediated signal transduction	cell projection membrane|clathrin-coated endocytic vesicle|coated pit|endosome|intercellular bridge|melanosome	GTP binding|GTPase activity|phosphatidylinositol-4,5-bisphosphate binding				0	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)			BRCA - Breast invasive adenocarcinoma(302;0.248)		CGTTTCTTTCGTTTACTGTTC	0.577												
FLT3	2322	broad.mit.edu	37	13	28608254	28608254	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr13:28608254A>G	uc001urw.2	-	14	1884	c.1802T>C	c.(1801-1803)CTC>CCC	p.L601P	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Missense_Mutation_p.L601P	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	601	Cytoplasmic (Potential).				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity	p.D600_L601insFREYEYD(7)|p.D600_L601ins17(4)|p.L601_K602insREYEYDL(4)|p.L601_K602ins27(4)|p.D600_L601ins26(4)|p.L601_K602ins21(3)|p.L601_K602ins24(2)|p.D600_L601>HVDFREYEYD(2)|p.D600_L601ins20(2)|p.L601_K602ins15(1)|p.L601_K602ins33(1)|p.D600_L601insRGYEYD(1)|p.600_601>PTSQVTGSSDNEYFYVDFREYEYD(1)|p.D600_L601insVDFREYEY(1)|p.L601_K602insIREYEYDL(1)|p.600_601>PRGFYVDFREYEYD(1)|p.L601_K602ins29(1)|p.L601_K602ins28(1)|p.L601_K602ins20(1)|p.L601_K602insEYEYDL(1)|p.D600_L601ins28(1)|p.D600_L601ins22(1)|p.D600_L601ins21(1)		haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	CTCCCATTTGAGATCATATTC	0.368			Mis|O		AML|ALL							
IPO5	3843	broad.mit.edu	37	13	98634835	98634835	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr13:98634835G>A	uc001vnf.1	+	2	234	c.169G>A	c.(169-171)GAG>AAG	p.E57K	IPO5_uc001vne.2_Missense_Mutation_p.E75K|IPO5_uc010tik.1_Missense_Mutation_p.E57K|IPO5_uc010til.1_5'UTR	NM_002271	NP_002262	O00410	IPO5_HUMAN	importin 5	57	Importin N-terminal.				interspecies interaction between organisms|NLS-bearing substrate import into nucleus|ribosomal protein import into nucleus	cytoplasm|nuclear pore|nucleolus	GTPase inhibitor activity|protein transporter activity|Ran GTPase binding			ovary(1)|lung(1)|skin(1)	3						AGCTGCTGAAGAGGTACTACC	0.333												
FAM70B	348013	broad.mit.edu	37	13	114514841	114514841	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr13:114514841C>T	uc001vuh.2	+	9	973	c.946C>T	c.(946-948)CCC>TCC	p.P316S		NM_182614	NP_872420	Q8WV15	FA70B_HUMAN	family with sequence similarity 70, member B	316	Pro-rich.					integral to membrane					0	Lung NSC(43;0.00976)|all_neural(89;0.0337)|Hepatocellular(20;0.0877)|Medulloblastoma(90;0.163)|Lung SC(71;0.218)	all_lung(25;0.123)|all_epithelial(44;0.133)	all cancers(43;0.181)			CACCTACTTTCCCCCGGGGGA	0.557												
EFS	10278	broad.mit.edu	37	14	23828604	23828604	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr14:23828604C>T	uc001wjo.2	-	4	1691	c.1083G>A	c.(1081-1083)ATG>ATA	p.M361I	EFS_uc001wjp.2_Missense_Mutation_p.M268I|EFS_uc010tnm.1_Missense_Mutation_p.M192I	NM_005864	NP_005855	O43281	EFS_HUMAN	embryonal Fyn-associated substrate isoform 1	361			M -> I (in a colorectal cancer sample; somatic mutation).		cell adhesion|intracellular signal transduction	cytoplasm	SH3 domain binding	p.M361I(1)		large_intestine(1)	1	all_cancers(95;7.12e-06)			GBM - Glioblastoma multiforme(265;0.00649)		GGTCATCCTCCATCTCCCTGC	0.652												
PRPF39	55015	broad.mit.edu	37	14	45578844	45578844	+	Missense_Mutation	SNP	A	A	T			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr14:45578844A>T	uc001wvz.3	+	8	1207	c.1037A>T	c.(1036-1038)AAA>ATA	p.K346I	PRPF39_uc001wvy.3_Missense_Mutation_p.K225I|PRPF39_uc010and.2_Missense_Mutation_p.K136I|PRPF39_uc001wwa.1_5'Flank|SNORD127_uc010ane.2_5'Flank	NM_017922	NP_060392	Q86UA1	PRP39_HUMAN	PRP39 pre-mRNA processing factor 39 homolog	346	HAT 5.				mRNA processing|RNA splicing	nucleus	binding			ovary(1)|breast(1)	2						TTTCATGTGAAACCTTTGGAA	0.318												
TRPM1	4308	broad.mit.edu	37	15	31334409	31334409	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr15:31334409T>C	uc001zfm.2	-	16	1894	c.1766A>G	c.(1765-1767)AAG>AGG	p.K589R	TRPM1_uc010azy.2_Missense_Mutation_p.K496R|TRPM1_uc001zfl.2_RNA	NM_002420	NP_002411	Q7Z4N2	TRPM1_HUMAN	transient receptor potential cation channel,	589	Cytoplasmic (Potential).				cellular response to light stimulus|visual perception	integral to plasma membrane	calcium channel activity|receptor activity			ovary(2)|pancreas(1)|skin(1)	4		all_lung(180;1.92e-11)		all cancers(64;3.52e-16)|Epithelial(43;1.65e-11)|GBM - Glioblastoma multiforme(186;3.57e-05)|BRCA - Breast invasive adenocarcinoma(123;0.00533)|COAD - Colon adenocarcinoma(236;0.0609)|Lung(196;0.199)		ctttttcttctttttcttttt	0.413												
SEMA6D	80031	broad.mit.edu	37	15	48056166	48056166	+	Silent	SNP	T	T	C			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr15:48056166T>C	uc010bek.2	+	10	1227	c.867T>C	c.(865-867)GAT>GAC	p.D289D	SEMA6D_uc001zvw.2_Silent_p.D289D|SEMA6D_uc001zvx.1_Silent_p.D289D|SEMA6D_uc001zvy.2_Silent_p.D289D|SEMA6D_uc001zvz.2_Silent_p.D289D|SEMA6D_uc001zwa.2_Silent_p.D289D|SEMA6D_uc001zwb.2_Silent_p.D289D|SEMA6D_uc001zwc.2_Silent_p.D289D	NM_153618	NP_705871	Q8NFY4	SEM6D_HUMAN	semaphorin 6D isoform 4 precursor	289	Sema.|Extracellular (Potential).				axon guidance	cytoplasm|integral to membrane|plasma membrane	receptor activity			skin(3)|breast(1)	4		all_lung(180;0.000635)|Myeloproliferative disorder(241;0.116)|Melanoma(134;0.18)		all cancers(107;1.2e-11)|GBM - Glioblastoma multiforme(94;1.2e-06)		TCCCTGGAGATTCGTTTTTCT	0.473												
SHC4	399694	broad.mit.edu	37	15	49255112	49255112	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr15:49255112C>T	uc001zxb.1	-	1	530	c.101G>A	c.(100-102)CGG>CAG	p.R34Q		NM_203349	NP_976224	Q6S5L8	SHC4_HUMAN	rai-like protein	34	CH2.				intracellular signal transduction	cell junction|postsynaptic membrane				ovary(3)|pancreas(2)	5		all_lung(180;0.00466)		all cancers(107;9.4e-08)|GBM - Glioblastoma multiforme(94;5.94e-07)		CGACTCGTTCCGAAAGCGGCT	0.657												
C15orf27	123591	broad.mit.edu	37	15	76430152	76430152	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr15:76430152G>A	uc002bbq.2	+	3	298	c.143G>A	c.(142-144)CGG>CAG	p.R48Q	C15orf27_uc010bkp.2_5'UTR|C15orf27_uc002bbr.2_5'UTR	NM_152335	NP_689548	Q2M3C6	CO027_HUMAN	hypothetical protein LOC123591	48						integral to membrane					0						TTTGCCTATCGGGACTTGCCC	0.527												
NKD1	85407	broad.mit.edu	37	16	50667166	50667166	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr16:50667166G>A	uc002egg.1	+	10	1111	c.887G>A	c.(886-888)CGC>CAC	p.R296H		NM_033119	NP_149110	Q969G9	NKD1_HUMAN	naked cuticle homolog 1	296					Wnt receptor signaling pathway	cytoplasm|plasma membrane	calcium ion binding|protein binding				0		all_cancers(37;0.229)		GBM - Glioblastoma multiforme(240;0.243)		ACTCGATCTCGCTCCCATGAG	0.542												
SLC38A8	146167	broad.mit.edu	37	16	84075604	84075604	+	Silent	SNP	G	G	A	rs147597105	byFrequency	TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr16:84075604G>A	uc002fhg.1	-	1	159	c.159C>T	c.(157-159)GGC>GGT	p.G53G		NM_001080442	NP_001073911	A6NNN8	S38A8_HUMAN	solute carrier family 38, member 8	53					amino acid transport|sodium ion transport	integral to membrane					0						GGACCACTCCGCCCGCTTTGG	0.632												
SLC43A2	124935	broad.mit.edu	37	17	1494653	1494653	+	Missense_Mutation	SNP	T	T	C			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr17:1494653T>C	uc002fsv.2	-	8	930	c.841A>G	c.(841-843)AGT>GGT	p.S281G	SLC43A2_uc002fsu.2_Missense_Mutation_p.S281G|SLC43A2_uc002fsw.2_Missense_Mutation_p.S281G|SLC43A2_uc002fsx.2_Missense_Mutation_p.S281G|SLC43A2_uc010vqo.1_Missense_Mutation_p.S144G	NM_152346	NP_689559	Q8N370	LAT4_HUMAN	solute carrier family 43, member 2	281					cellular nitrogen compound metabolic process|ion transport	integral to membrane|plasma membrane					0				UCEC - Uterine corpus endometrioid carcinoma (25;0.0883)		TCCTTGGCACTCCTCATGGAG	0.642												
ALOX15	246	broad.mit.edu	37	17	4535309	4535309	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr17:4535309G>A	uc002fyh.2	-	13	1698	c.1684C>T	c.(1684-1686)CGG>TGG	p.R562W	ALOX15_uc010vsd.1_Missense_Mutation_p.R523W|ALOX15_uc010vse.1_Missense_Mutation_p.R584W	NM_001140	NP_001131	P16050	LOX15_HUMAN	arachidonate 15-lipoxygenase	562	Lipoxygenase.				inflammatory response|leukotriene biosynthetic process	nucleus	arachidonate 15-lipoxygenase activity|iron ion binding|lipoxygenase activity			skin(3)|ovary(1)|lung(1)	5				READ - Rectum adenocarcinoma(115;0.0327)	Ciclopirox(DB01188)|Masoprocol(DB00179)|Zileuton(DB00744)	GGGGGCAGCCGCATCGTGCAG	0.607												
WSB1	26118	broad.mit.edu	37	17	25628925	25628925	+	Missense_Mutation	SNP	G	G	C			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr17:25628925G>C	uc002gzd.1	+	2	468	c.152G>C	c.(151-153)TGG>TCG	p.W51S	WSB1_uc010vzy.1_Missense_Mutation_p.W51S|WSB1_uc010vzz.1_Missense_Mutation_p.W20S|WSB1_uc010crf.1_Intron|WSB1_uc002gze.1_Intron|WSB1_uc002gzf.1_RNA	NM_015626	NP_056441	Q9Y6I7	WSB1_HUMAN	WD repeat and SOCS box-containing 1 isoform 1	51	WD 1.				intracellular signal transduction	intracellular	protein binding				0	all_cancers(1;2e-13)|all_epithelial(1;4.8e-15)|Lung NSC(42;0.00152)		BRCA - Breast invasive adenocarcinoma(3;0.0152)	UCEC - Uterine corpus endometrioid carcinoma (53;0.154)		TACTTTGCTTGGTCACAAGGA	0.418												
ZACN	353174	broad.mit.edu	37	17	74075792	74075792	+	Nonsense_Mutation	SNP	C	C	T	rs140302218	byFrequency	TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr17:74075792C>T	uc002jqn.2	+	3	315	c.232C>T	c.(232-234)CGA>TGA	p.R78*	ZACN_uc002jqo.2_RNA|ZACN_uc010dgu.2_Intron	NM_180990	NP_851321	Q401N2	ZACN_HUMAN	zinc activated ligand-gated ion channel	78	Extracellular (Potential).				response to zinc ion	integral to membrane|membrane fraction|plasma membrane|postsynaptic membrane	extracellular ligand-gated ion channel activity|receptor activity				0						GGACATCCTGCGATACACAAT	0.582												
CCDC102B	79839	broad.mit.edu	37	18	66504246	66504246	+	Silent	SNP	G	G	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr18:66504246G>A	uc002lkk.2	+	4	469	c.246G>A	c.(244-246)AAG>AAA	p.K82K	CCDC102B_uc002lki.2_Silent_p.K82K|CCDC102B_uc002lkj.1_Silent_p.K82K	NM_001093729	NP_001087198	Q68D86	C102B_HUMAN	coiled-coil domain containing 102B	82	Potential.									ovary(1)|lung(1)|skin(1)	3		Esophageal squamous(42;0.0559)|Colorectal(73;0.0604)				AAGAAGTCAAGGCCAGAGCTG	0.473												
NETO1	81832	broad.mit.edu	37	18	70417353	70417353	+	Silent	SNP	G	G	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr18:70417353G>A	uc002lkw.2	-	9	1769	c.1485C>T	c.(1483-1485)ATC>ATT	p.I495I	NETO1_uc002lkx.1_Silent_p.I494I|NETO1_uc002lky.1_Silent_p.I495I	NM_138966	NP_620416	Q8TDF5	NETO1_HUMAN	neuropilin- and tolloid-like protein 1 isoform 3	495	Cytoplasmic (Potential).				memory|regulation of long-term neuronal synaptic plasticity|visual learning	cell junction|excitatory synapse|extracellular region|integral to membrane|postsynaptic density|postsynaptic membrane	receptor activity			ovary(2)|skin(2)	4		Esophageal squamous(42;0.129)		READ - Rectum adenocarcinoma(1;0.0487)		GCACCTCTTCGATTTCATCTA	0.468												
GNG7	2788	broad.mit.edu	37	19	2515092	2515092	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr19:2515092G>T	uc002lwd.2	-	5	372	c.135C>A	c.(133-135)AAC>AAA	p.N45K	GNG7_uc010dte.1_Intron	NM_052847	NP_443079	O60262	GBG7_HUMAN	guanine nucleotide binding protein (G protein),	45					cellular response to glucagon stimulus|energy reserve metabolic process|G-protein coupled receptor protein signaling pathway|regulation of G-protein coupled receptor protein signaling pathway|synaptic transmission	heterotrimeric G-protein complex	signal transducer activity				0		Hepatocellular(1079;0.137)		UCEC - Uterine corpus endometrioid carcinoma (162;6.64e-05)|OV - Ovarian serous cystadenocarcinoma(105;1.09e-113)|Epithelial(107;3.79e-112)|all cancers(105;1.67e-104)|BRCA - Breast invasive adenocarcinoma(158;0.00136)|STAD - Stomach adenocarcinoma(1328;0.18)		GCAGGGGGTCGTTCCGGGCAT	0.408												
PGLYRP2	114770	broad.mit.edu	37	19	15582872	15582872	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr19:15582872G>A	uc002nbf.3	-	3	1305	c.1172C>T	c.(1171-1173)GCG>GTG	p.A391V	PGLYRP2_uc002nbg.3_Missense_Mutation_p.A391V	NM_052890	NP_443122	Q96PD5	PGRP2_HUMAN	peptidoglycan recognition protein 2 precursor	391					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptide amidation|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(3)	3						CCGATAAGGCGCCGCTCCCCA	0.662												
C19orf47	126526	broad.mit.edu	37	19	40829971	40829971	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr19:40829971G>A	uc002oni.3	-	8	717	c.716C>T	c.(715-717)ACG>ATG	p.T239M	C19orf47_uc002ong.2_Missense_Mutation_p.T98M|C19orf47_uc002onh.2_Missense_Mutation_p.T172M	NM_178830	NP_849152	Q8N9M1	CS047_HUMAN	hypothetical protein LOC126526	239										ovary(1)|skin(1)	2			Lung(22;0.000636)			AAACACAGACGTCCTATGGAG	0.627												
CYP2A13	1553	broad.mit.edu	37	19	41596049	41596049	+	Missense_Mutation	SNP	A	A	T	rs149580014		TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr19:41596049A>T	uc002opt.2	+	3	450	c.441A>T	c.(439-441)GAA>GAT	p.E147D		NM_000766	NP_000757	Q16696	CP2AD_HUMAN	cytochrome P450, family 2, subfamily A,	147					xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	aromatase activity|coumarin 7-hydroxylase activity|electron carrier activity|heme binding			ovary(2)|skin(1)	3					Clomipramine(DB01242)|Nicotine(DB00184)	GCATCGAGGAACGCATCCAGG	0.697												
DHX34	9704	broad.mit.edu	37	19	47858523	47858523	+	Silent	SNP	G	G	A	rs150145021	byFrequency	TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr19:47858523G>A	uc010xyn.1	+	3	1274	c.933G>A	c.(931-933)TCG>TCA	p.S311S	DHX34_uc010elc.1_Silent_p.S311S	NM_014681	NP_055496	Q14147	DHX34_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 34	311	Helicase ATP-binding.					intracellular	ATP binding|ATP-dependent helicase activity|RNA binding|zinc ion binding			ovary(4)|upper_aerodigestive_tract(1)	5		all_cancers(25;1.65e-09)|all_epithelial(76;9.95e-08)|all_lung(116;7.27e-07)|Lung NSC(112;1.6e-06)|Ovarian(192;0.0139)|all_neural(266;0.026)|Breast(70;0.0503)		all cancers(93;7.16e-05)|OV - Ovarian serous cystadenocarcinoma(262;0.000489)|GBM - Glioblastoma multiforme(486;0.00413)|Epithelial(262;0.0132)		TCCTCATGTCGGCCACCATCA	0.587												
ZNF584	201514	broad.mit.edu	37	19	58928789	58928789	+	Nonsense_Mutation	SNP	G	G	T			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr19:58928789G>T	uc002qsp.2	+	4	1356	c.904G>T	c.(904-906)GAA>TAA	p.E302*	ZNF584_uc010yia.1_RNA|ZNF584_uc002qsr.2_Nonsense_Mutation_p.E257*|ZNF584_uc010yib.1_3'UTR	NM_173548	NP_775819	Q8IVC4	ZN584_HUMAN	zinc finger protein 584	302	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(17;5.3e-17)|all_epithelial(17;3.71e-12)|Lung NSC(17;8.3e-05)|Colorectal(82;0.000147)|all_lung(17;0.000386)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0271)		TGAGTGTACAGAATGTGGGAA	0.443												
ZNF584	201514	broad.mit.edu	37	19	58929002	58929002	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr19:58929002C>A	uc002qsp.2	+	4	1569	c.1117C>A	c.(1117-1119)CAG>AAG	p.Q373K	ZNF584_uc010yia.1_RNA|ZNF584_uc002qsr.2_Missense_Mutation_p.Q328K|ZNF584_uc010yib.1_3'UTR	NM_173548	NP_775819	Q8IVC4	ZN584_HUMAN	zinc finger protein 584	373	C2H2-type 7.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		all_cancers(17;5.3e-17)|all_epithelial(17;3.71e-12)|Lung NSC(17;8.3e-05)|Colorectal(82;0.000147)|all_lung(17;0.000386)|Renal(17;0.00528)|all_neural(62;0.0133)|Ovarian(87;0.156)|Medulloblastoma(540;0.232)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0271)		CAATCGGCACCAGCAGTTCCA	0.507												
DYSF	8291	broad.mit.edu	37	2	71743364	71743364	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr2:71743364T>A	uc002sie.2	+	8	1223	c.847T>A	c.(847-849)TTT>ATT	p.F283I	DYSF_uc010feg.2_Missense_Mutation_p.F314I|DYSF_uc010feh.2_Missense_Mutation_p.F283I|DYSF_uc002sig.3_Missense_Mutation_p.F283I|DYSF_uc010yqx.1_RNA|DYSF_uc010fee.2_Missense_Mutation_p.F283I|DYSF_uc010fef.2_Missense_Mutation_p.F314I|DYSF_uc010fei.2_Missense_Mutation_p.F314I|DYSF_uc010fek.2_Missense_Mutation_p.F315I|DYSF_uc010fej.2_Missense_Mutation_p.F284I|DYSF_uc010fel.2_Missense_Mutation_p.F284I|DYSF_uc010feo.2_Missense_Mutation_p.F315I|DYSF_uc010fem.2_Missense_Mutation_p.F284I|DYSF_uc010fen.2_Missense_Mutation_p.F315I|DYSF_uc002sif.2_Missense_Mutation_p.F284I	NM_003494	NP_003485	O75923	DYSF_HUMAN	dysferlin isoform 8	283	Cytoplasmic (Potential).|C2 2.					cytoplasmic vesicle membrane|integral to membrane|sarcolemma	calcium-dependent phospholipid binding			ovary(3)|breast(2)|pancreas(1)|skin(1)	7						TGAGCCCATCTTTATCACGGT	0.423												
LRP1B	53353	broad.mit.edu	37	2	141232848	141232848	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr2:141232848C>T	uc002tvj.1	-	60	10456	c.9484G>A	c.(9484-9486)GGA>AGA	p.G3162R		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	3162	Extracellular (Potential).|LDL-receptor class B 30.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		TGATTGGTTCCATCCATTCCA	0.373										TSP Lung(27;0.18)		
STAM2	10254	broad.mit.edu	37	2	152992030	152992030	+	Silent	SNP	A	A	C			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr2:152992030A>C	uc002tyc.3	-	8	1142	c.792T>G	c.(790-792)ACT>ACG	p.T264T	STAM2_uc010foa.1_Silent_p.T264T|STAM2_uc002tyd.2_Silent_p.T264T	NM_005843	NP_005834	O75886	STAM2_HUMAN	signal transducing adaptor molecule 2	264					cellular membrane organization|endosome transport|epidermal growth factor receptor signaling pathway|intracellular protein transport|negative regulation of epidermal growth factor receptor signaling pathway	cytosol|early endosome membrane	protein binding			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.22)		TACCTGCCTCAGTCTCTATGT	0.308												
DPP4	1803	broad.mit.edu	37	2	162891790	162891790	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr2:162891790C>T	uc002ubz.2	-	9	1219	c.658G>A	c.(658-660)GGC>AGC	p.G220S	DPP4_uc010fpb.2_5'UTR	NM_001935	NP_001926	P27487	DPP4_HUMAN	dipeptidylpeptidase IV	220	Extracellular (Potential).				cell adhesion|endothelial cell migration|negative regulation of extracellular matrix disassembly|positive regulation of cell proliferation|proteolysis|regulation of cell-cell adhesion mediated by integrin|response to hypoxia|T cell activation|T cell costimulation	apical plasma membrane|cell surface|endocytic vesicle|extracellular region|integral to membrane|invadopodium membrane|lamellipodium membrane|membrane raft	aminopeptidase activity|dipeptidyl-peptidase activity|protease binding|protein homodimerization activity|receptor activity|receptor binding|serine-type endopeptidase activity			ovary(3)	3					Sitagliptin(DB01261)	AAAAAAGTGCCGTTTGGAGAC	0.423												
TTN	7273	broad.mit.edu	37	2	179643826	179643826	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr2:179643826C>T	uc010zfg.1	-	24	4207	c.3983G>A	c.(3982-3984)GGC>GAC	p.G1328D	TTN_uc010zfh.1_Missense_Mutation_p.G1282D|TTN_uc010zfi.1_Missense_Mutation_p.G1282D|TTN_uc010zfj.1_Missense_Mutation_p.G1282D|TTN_uc002unb.2_Missense_Mutation_p.G1328D|uc002unc.1_Intron	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	1328							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GATGCGCTTGCCATCTTTGTA	0.363												
AOX1	316	broad.mit.edu	37	2	201531408	201531408	+	Splice_Site	SNP	A	A	G			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr2:201531408A>G	uc002uvx.2	+	32	3645	c.3544_splice	c.e32-2	p.N1182_splice	AOX1_uc010zhf.1_Splice_Site_p.N738_splice|AOX1_uc010fsu.2_Splice_Site_p.N548_splice	NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1						inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	TTTTAATACTAGAACATCAGA	0.373												
AOX1	316	broad.mit.edu	37	2	201531430	201531430	+	Silent	SNP	C	C	T			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr2:201531430C>T	uc002uvx.2	+	32	3665	c.3564C>T	c.(3562-3564)GTC>GTT	p.V1188V	AOX1_uc010zhf.1_Silent_p.V744V|AOX1_uc010fsu.2_Silent_p.V554V	NM_001159	NP_001150	Q06278	ADO_HUMAN	aldehyde oxidase 1	1188					inflammatory response|reactive oxygen species metabolic process	cytoplasm	2 iron, 2 sulfur cluster binding|aldehyde oxidase activity|flavin adenine dinucleotide binding|iron ion binding|NAD binding|xanthine dehydrogenase activity			ovary(4)|pancreas(1)|skin(1)	6					Brimonidine(DB00484)|Chlorpromazine(DB00477)|Famciclovir(DB00426)|Menadione(DB00170)|Methotrexate(DB00563)|NADH(DB00157)|Palonosetron(DB00377)|Penciclovir(DB00299)|Raloxifene(DB00481)|Zaleplon(DB00962)|Zonisamide(DB00909)	CAGACATTGTCATGGATGTTG	0.383												
IHH	3549	broad.mit.edu	37	2	219925067	219925067	+	Silent	SNP	T	T	C			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr2:219925067T>C	uc002vjo.1	-	1	123	c.123A>G	c.(121-123)CCA>CCG	p.P41P	hsa-mir-3131|MI0014151_5'Flank	NM_002181	NP_002172	Q14623	IHH_HUMAN	Indian hedgehog homolog precursor	41					cell-cell signaling|intein-mediated protein splicing|proteolysis	extracellular space|plasma membrane	cholesterol binding|patched binding|peptidase activity			breast(1)	1		Renal(207;0.0915)		Epithelial(149;1.13e-06)|all cancers(144;0.000188)|LUSC - Lung squamous cell carcinoma(224;0.008)|Lung(261;0.00942)		CGAGTTTGCGTGGCGGTCGCC	0.692												
SLC23A2	9962	broad.mit.edu	37	20	4843508	4843508	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr20:4843508C>T	uc002wlg.1	-	14	1777	c.1402G>A	c.(1402-1404)GCT>ACT	p.A468T	SLC23A2_uc010zqr.1_Missense_Mutation_p.A353T|SLC23A2_uc002wlh.1_Missense_Mutation_p.A468T	NM_005116	NP_005107	Q9UGH3	S23A2_HUMAN	solute carrier family 23 (nucleobase	468	Helical; (Potential).				L-ascorbic acid metabolic process|molecular hydrogen transport|nucleobase, nucleoside, nucleotide and nucleic acid metabolic process|transepithelial L-ascorbic acid transport	apical plasma membrane|integral to plasma membrane|membrane fraction	nucleobase transmembrane transporter activity|sodium-dependent L-ascorbate transmembrane transporter activity|sodium-dependent multivitamin transmembrane transporter activity			ovary(2)	2						ATGCCCAGAGCGAGCATGAGG	0.597												
KIF3B	9371	broad.mit.edu	37	20	30897661	30897661	+	Silent	SNP	G	G	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr20:30897661G>A	uc002wxq.2	+	2	248	c.81G>A	c.(79-81)TCG>TCA	p.S27S	KIF3B_uc010ztv.1_Silent_p.S27S|KIF3B_uc010ztw.1_Silent_p.S27S	NM_004798	NP_004789	O15066	KIF3B_HUMAN	kinesin family member 3B	27	Kinesin-motor.				anterograde axon cargo transport|blood coagulation|determination of left/right symmetry|mitotic centrosome separation|plus-end-directed vesicle transport along microtubule|spindle assembly involved in mitosis	centrosome|cytosol|kinesin II complex|plus-end kinesin complex|spindle microtubule	ATP binding|plus-end-directed microtubule motor activity|Rho GTPase binding			central_nervous_system(3)|ovary(2)	5			UCEC - Uterine corpus endometrioid carcinoma (5;0.0241)			AGGCTGCTTCGTATGACAAAG	0.507												
CASS4	57091	broad.mit.edu	37	20	55033575	55033575	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr20:55033575G>A	uc002xxp.2	+	7	2358	c.2133G>A	c.(2131-2133)ATG>ATA	p.M711I	CASS4_uc002xxr.2_Missense_Mutation_p.M711I|CASS4_uc010zze.1_Missense_Mutation_p.M657I|CASS4_uc010gio.2_Missense_Mutation_p.M274I	NM_001164116	NP_001157588	Q9NQ75	CASS4_HUMAN	HEF-like protein isoform a	711					cell adhesion	cytoplasm|cytoskeleton|focal adhesion	two-component sensor activity			ovary(2)|skin(1)	3						TGGTCATCATGGTGGGACAGA	0.602												
LAMA5	3911	broad.mit.edu	37	20	60909261	60909261	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr20:60909261G>A	uc002ycq.2	-	22	2787	c.2720C>T	c.(2719-2721)GCG>GTG	p.A907V		NM_005560	NP_005551	O15230	LAMA5_HUMAN	laminin alpha 5 precursor	907	Domain IV 1 (domain IV B).				angiogenesis|cell proliferation|cell recognition|cytoskeleton organization|endothelial cell differentiation|focal adhesion assembly|integrin-mediated signaling pathway|regulation of cell adhesion|regulation of cell migration|regulation of embryonic development|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-11 complex	integrin binding			ovary(1)|pancreas(1)|skin(1)	3	Breast(26;1.57e-08)		BRCA - Breast invasive adenocarcinoma(19;4.36e-06)		Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TGCCATCTGCGCGTAGCCCCT	0.682												
HESX1	8820	broad.mit.edu	37	3	57232304	57232304	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr3:57232304C>T	uc003din.3	-	4	813	c.479G>A	c.(478-480)CGT>CAT	p.R160H		NM_003865	NP_003856	Q9UBX0	HESX1_HUMAN	HESX homeobox 1	160	Homeobox.					nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0109)|Kidney(284;0.0126)		CAGTTTTGCACGCCGATTTTG	0.294												
GOLIM4	27333	broad.mit.edu	37	3	167750460	167750460	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr3:167750460C>T	uc003ffe.2	-	9	1368	c.1024G>A	c.(1024-1026)GCC>ACC	p.A342T	GOLIM4_uc011bpe.1_Missense_Mutation_p.A342T|GOLIM4_uc011bpf.1_Missense_Mutation_p.A314T|GOLIM4_uc011bpg.1_Missense_Mutation_p.A314T	NM_014498	NP_055313	O00461	GOLI4_HUMAN	golgi integral membrane protein 4	342	Glu-rich.|Lumenal (Potential).				transport	cis-Golgi network|endocytic vesicle|endosome membrane|Golgi cisterna membrane|Golgi lumen|integral to membrane|nucleus				breast(4)|skin(1)	5						TCCTCCAGGGCCTTTCTGTGC	0.547												
EXOC1	55763	broad.mit.edu	37	4	56768601	56768601	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr4:56768601G>A	uc003hbe.1	+	18	2587	c.2429G>A	c.(2428-2430)CGT>CAT	p.R810H	EXOC1_uc003hbf.1_Missense_Mutation_p.R810H|EXOC1_uc003hbg.1_Missense_Mutation_p.R795H	NM_018261	NP_060731	Q9NV70	EXOC1_HUMAN	exocyst complex component 1 isoform 1	810					exocytosis|protein transport	exocyst	protein binding			ovary(2)|skin(2)|lung(1)|central_nervous_system(1)	6	Glioma(25;0.08)|all_neural(26;0.101)					CAAGAACTTCGTAAAGTCATT	0.383												
GRID2	2895	broad.mit.edu	37	4	94316852	94316852	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr4:94316852C>G	uc011cdt.1	+	9	1598	c.1340C>G	c.(1339-1341)ACT>AGT	p.T447S	GRID2_uc011cdu.1_Missense_Mutation_p.T352S	NM_001510	NP_001501	O43424	GRID2_HUMAN	glutamate receptor, ionotropic, delta 2	447	Extracellular (Potential).				glutamate signaling pathway	cell junction|integral to plasma membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(3)|skin(2)|large_intestine(1)	6		Hepatocellular(203;0.114)|all_hematologic(202;0.177)		OV - Ovarian serous cystadenocarcinoma(123;3.22e-06)|LUSC - Lung squamous cell carcinoma(81;0.185)|Lung(65;0.191)	L-Glutamic Acid(DB00142)	CGTGTAGTAACTGTTCTGGTA	0.383												
C4orf37	285555	broad.mit.edu	37	4	99049733	99049733	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr4:99049733C>A	uc003htt.1	-	3	323	c.233G>T	c.(232-234)AGA>ATA	p.R78I		NM_174952	NP_777612	Q8N412	CD037_HUMAN	hypothetical protein LOC285555	78											0				OV - Ovarian serous cystadenocarcinoma(123;2.27e-08)		TGTAGGTGATCTTGAAATTTT	0.313												
KIAA1109	84162	broad.mit.edu	37	4	123176382	123176382	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr4:123176382A>G	uc003ieh.2	+	38	6367	c.6322A>G	c.(6322-6324)ATA>GTA	p.I2108V	KIAA1109_uc003iel.1_Missense_Mutation_p.I43V|KIAA1109_uc003iek.2_Missense_Mutation_p.I727V	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	2108					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						ACTATGTAATATACTACACCA	0.333												
ADAD1	132612	broad.mit.edu	37	4	123336720	123336720	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr4:123336720G>T	uc003ieo.2	+	11	1668	c.1436G>T	c.(1435-1437)GGA>GTA	p.G479V	ADAD1_uc003iep.2_Missense_Mutation_p.G468V|ADAD1_uc003ieq.2_Missense_Mutation_p.G461V	NM_139243	NP_640336	Q96M93	ADAD1_HUMAN	adenosine deaminase domain containing 1	479	A to I editase.				multicellular organismal development|RNA processing	nucleus	adenosine deaminase activity|double-stranded RNA binding				0						TGGGCACAAGGAGATGTTTCT	0.348												
SPATA5	166378	broad.mit.edu	37	4	123868603	123868603	+	Silent	SNP	A	A	G			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr4:123868603A>G	uc003iez.3	+	9	1747	c.1674A>G	c.(1672-1674)GGA>GGG	p.G558G	SPATA5_uc003iey.2_Silent_p.G557G	NM_145207	NP_660208	Q8NB90	SPAT5_HUMAN	spermatogenesis associated 5	558					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrion	ATP binding|nucleoside-triphosphatase activity				0						GTGCTCATGGATACGTTGGAG	0.468												
ADCY2	108	broad.mit.edu	37	5	7802364	7802364	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr5:7802364G>A	uc003jdz.1	+	21	2729	c.2662G>A	c.(2662-2664)GTC>ATC	p.V888I	ADCY2_uc011cmo.1_Missense_Mutation_p.V708I|ADCY2_uc010itm.1_Missense_Mutation_p.V84I	NM_020546	NP_065433	Q08462	ADCY2_HUMAN	adenylate cyclase 2	888	Cytoplasmic (Potential).				activation of adenylate cyclase activity by G-protein signaling pathway|activation of phospholipase C activity|activation of protein kinase A activity|cellular response to glucagon stimulus|energy reserve metabolic process|inhibition of adenylate cyclase activity by G-protein signaling pathway|nerve growth factor receptor signaling pathway|synaptic transmission|transmembrane transport|water transport	cytoplasm|dendrite|integral to membrane|plasma membrane	ATP binding|metal ion binding	p.V888I(2)		ovary(5)|pancreas(1)|skin(1)	7						CTGCGTCTGCGTCATGTTTGC	0.488												
VCAN	1462	broad.mit.edu	37	5	82808156	82808156	+	Missense_Mutation	SNP	T	T	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr5:82808156T>A	uc003kii.3	+	6	1339	c.983T>A	c.(982-984)TTT>TAT	p.F328Y	VCAN_uc003kij.3_Missense_Mutation_p.F328Y|VCAN_uc010jau.2_Missense_Mutation_p.F328Y|VCAN_uc003kik.3_Missense_Mutation_p.F328Y|VCAN_uc003kih.3_Missense_Mutation_p.F328Y	NM_004385	NP_004376	P13611	CSPG2_HUMAN	versican isoform 1 precursor	328	Link 2.				cell adhesion|cell recognition|glial cell migration	extracellular space|proteinaceous extracellular matrix	calcium ion binding|hyaluronic acid binding|sugar binding			ovary(7)|skin(6)|lung(2)|central_nervous_system(1)	16		Lung NSC(167;0.0216)|all_lung(232;0.0251)|Ovarian(174;0.142)		OV - Ovarian serous cystadenocarcinoma(54;2.47e-41)|Epithelial(54;2.51e-34)|all cancers(79;5.19e-29)		CTGTATCGTTTTGAGAACCAG	0.493												
PCDHB10	56126	broad.mit.edu	37	5	140572528	140572528	+	Missense_Mutation	SNP	G	G	A	rs2907324		TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr5:140572528G>A	uc003lix.2	+	1	577	c.403G>A	c.(403-405)GAC>AAC	p.D135N		NM_018930	NP_061753	Q9UN67	PCDBA_HUMAN	protocadherin beta 10 precursor	135	Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding			ovary(1)|skin(1)	2			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			AGTATTTCAGGACAAAGAAAC	0.408												
FAT2	2196	broad.mit.edu	37	5	150945845	150945845	+	Missense_Mutation	SNP	C	C	T	rs147663319		TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr5:150945845C>T	uc003lue.3	-	1	2661	c.2648G>A	c.(2647-2649)CGC>CAC	p.R883H	GM2A_uc011dcs.1_Intron|FAT2_uc010jhx.1_Missense_Mutation_p.R883H	NM_001447	NP_001438	Q9NYQ8	FAT2_HUMAN	FAT tumor suppressor 2 precursor	883	Extracellular (Potential).|Cadherin 7.				epithelial cell migration|homophilic cell adhesion	cell-cell adherens junction|integral to membrane|nucleus	calcium ion binding			ovary(4)|upper_aerodigestive_tract(1)|skin(1)	6		Medulloblastoma(196;0.0912)|all_hematologic(541;0.104)	KIRC - Kidney renal clear cell carcinoma(527;0.000785)|Kidney(363;0.00101)			CTCTGATTCGCGGTCCAGGTG	0.552												
PECI	10455	broad.mit.edu	37	6	4119493	4119493	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr6:4119493G>A	uc003mwf.2	-	8	849	c.812C>T	c.(811-813)CCA>CTA	p.P271L	C6orf201_uc003mwa.3_Intron|C6orf201_uc003mvz.3_Intron|C6orf201_uc011dhw.1_Intron|C6orf201_uc003mwb.3_Intron|PECI_uc003mwc.2_Missense_Mutation_p.P104L|PECI_uc003mwd.2_Missense_Mutation_p.P241L|PECI_uc003mwe.2_Missense_Mutation_p.P118L|PECI_uc010jnr.1_RNA	NM_206836	NP_996667	O75521	ECI2_HUMAN	peroxisomal D3,D2-enoyl-CoA isomerase isoform 2	271	ECH-like.				fatty acid metabolic process	mitochondrion|peroxisomal matrix	dodecenoyl-CoA delta-isomerase activity|fatty-acyl-CoA binding				0	Ovarian(93;0.0925)	all_hematologic(90;0.0895)				GTGACTAAATGGTGTATGAAA	0.328												
TNXB	7148	broad.mit.edu	37	6	32035600	32035600	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr6:32035600G>T	uc003nzl.2	-	18	6584	c.6382C>A	c.(6382-6384)CAG>AAG	p.Q2128K		NM_019105	NP_061978	P22105	TENX_HUMAN	tenascin XB isoform 1 precursor	2200	Fibronectin type-III 14.				actin cytoskeleton organization|cell adhesion|collagen metabolic process|elastic fiber assembly|signal transduction	extracellular space|intracellular|proteinaceous extracellular matrix	heparin binding|integrin binding				0						TCCTTGTACTGCACGGTGAAG	0.667												
C6orf174	387104	broad.mit.edu	37	6	127797234	127797234	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr6:127797234C>T	uc003qbd.2	-	6	2802	c.1937G>A	c.(1936-1938)CGG>CAG	p.R646Q	C6orf174_uc003qbc.2_5'Flank	NM_001012279	NP_001012279	Q5TF21	CF174_HUMAN	hypothetical protein LOC387104 precursor	646	Potential.					integral to membrane				breast(3)|ovary(2)|skin(1)	6				GBM - Glioblastoma multiforme(226;0.026)|all cancers(137;0.161)		CAGGTGCTGCCGCAGCTCCGA	0.637												
SYNE1	23345	broad.mit.edu	37	6	152647757	152647757	+	Silent	SNP	A	A	C			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr6:152647757A>C	uc010kiw.2	-	79	15569	c.14967T>G	c.(14965-14967)ACT>ACG	p.T4989T	SYNE1_uc003qot.3_Silent_p.T4918T|SYNE1_uc003qou.3_Silent_p.T4989T|SYNE1_uc010kiz.2_Silent_p.T744T	NM_182961	NP_892006	Q8NF91	SYNE1_HUMAN	spectrin repeat containing, nuclear envelope 1	4989	Cytoplasmic (Potential).				cell death|cytoskeletal anchoring at nuclear membrane|Golgi organization|muscle cell differentiation|nuclear matrix anchoring at nuclear membrane	cytoskeleton|Golgi apparatus|integral to membrane|nuclear outer membrane|postsynaptic membrane|sarcomere|SUN-KASH complex	actin binding|lamin binding			central_nervous_system(15)|upper_aerodigestive_tract(9)|ovary(8)|skin(6)|large_intestine(5)|pancreas(2)	45		Ovarian(120;0.0955)	BRCA - Breast invasive adenocarcinoma(37;0.243)	OV - Ovarian serous cystadenocarcinoma(155;2.24e-10)		TATATATTTCAGTCAAGGTAG	0.413										HNSCC(10;0.0054)		
FAM188B	84182	broad.mit.edu	37	7	30922556	30922556	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr7:30922556G>A	uc003tbt.2	+	17	2250	c.2173G>A	c.(2173-2175)GAG>AAG	p.E725K	FAM188B_uc010kwe.2_Missense_Mutation_p.E696K|AQP1_uc011kac.1_Missense_Mutation_p.E71K|FAM188B_uc003tbu.2_Missense_Mutation_p.E245K	NM_032222	NP_115598	Q4G0A6	F188B_HUMAN	hypothetical protein LOC84182	725											0						AACCATCTCTGAGGACACAGA	0.582												
NUDCD3	23386	broad.mit.edu	37	7	44431997	44431997	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr7:44431997G>A	uc003tkz.2	-	5	1060	c.874C>T	c.(874-876)CGC>TGC	p.R292C	NUDCD3_uc010kye.2_RNA	NM_015332	NP_056147	Q8IVD9	NUDC3_HUMAN	NudC domain containing 3	292											0						GCCATGGAGCGCTCCTTGTTG	0.572												
POM121L12	285877	broad.mit.edu	37	7	53103920	53103920	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr7:53103920C>A	uc003tpz.2	+	1	572	c.556C>A	c.(556-558)CCC>ACC	p.P186T		NM_182595	NP_872401	Q8N7R1	P1L12_HUMAN	POM121 membrane glycoprotein-like 12	186											0						CAGCCAGTGCCCCAAGGGAAG	0.577												
GRM3	2913	broad.mit.edu	37	7	86416261	86416261	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr7:86416261G>A	uc003uid.2	+	3	2252	c.1153G>A	c.(1153-1155)GAG>AAG	p.E385K	GRM3_uc010lef.2_Missense_Mutation_p.E383K|GRM3_uc010leg.2_Missense_Mutation_p.E257K|GRM3_uc010leh.2_Intron	NM_000840	NP_000831	Q14832	GRM3_HUMAN	glutamate receptor, metabotropic 3 precursor	385	Extracellular (Potential).				synaptic transmission	integral to plasma membrane				lung(4)|ovary(3)|central_nervous_system(2)|skin(2)|haematopoietic_and_lymphoid_tissue(1)|prostate(1)	13	Esophageal squamous(14;0.0058)|all_lung(186;0.132)|Lung NSC(181;0.142)				Acamprosate(DB00659)|Nicotine(DB00184)	CAGCAACTACGAGCAAGAGTC	0.557												
C7orf61	402573	broad.mit.edu	37	7	100061261	100061261	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr7:100061261C>G	uc003uuz.1	-	2	358	c.112G>C	c.(112-114)GAC>CAC	p.D38H		NM_001004323	NP_001004323	Q8IZ16	CG061_HUMAN	hypothetical protein LOC402573	38											0						TTCTTGGAGTCAGGGTGTCCT	0.498												
FBXO24	26261	broad.mit.edu	37	7	100190614	100190614	+	Missense_Mutation	SNP	C	C	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr7:100190614C>A	uc003uvm.1	+	5	1060	c.767C>A	c.(766-768)ACC>AAC	p.T256N	FBXO24_uc010lha.1_RNA|FBXO24_uc003uvl.1_Missense_Mutation_p.T242N|FBXO24_uc003uvn.1_Intron|uc011kjy.1_RNA|FBXO24_uc011kjz.1_Missense_Mutation_p.T294N|FBXO24_uc011kka.1_Missense_Mutation_p.T244N	NM_033506	NP_277041	O75426	FBX24_HUMAN	F-box only protein 24 isoform 1	256						ubiquitin ligase complex	ubiquitin-protein ligase activity			ovary(3)|skin(1)	4	Lung NSC(181;0.0261)|all_lung(186;0.0392)|Esophageal squamous(72;0.0439)					GGTCAGGAGACCCAGCGGGCT	0.418												
ZNF282	8427	broad.mit.edu	37	7	148895532	148895532	+	Silent	SNP	G	G	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr7:148895532G>A	uc003wfm.2	+	2	378	c.273G>A	c.(271-273)TTG>TTA	p.L91L	ZNF282_uc011kun.1_Silent_p.L91L|ZNF282_uc003wfn.2_Silent_p.L31L|ZNF282_uc003wfo.2_Silent_p.L31L	NM_003575	NP_003566	Q9UDV7	ZN282_HUMAN	zinc finger protein 282	91					negative regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	Melanoma(164;0.15)		OV - Ovarian serous cystadenocarcinoma(82;0.00171)	Lung(243;0.145)		AGCCCCAGTTGCCCACAGCAG	0.617												
DNAJB6	10049	broad.mit.edu	37	7	157155939	157155939	+	Silent	SNP	G	G	A	rs141947451	by1000genomes	TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr7:157155939G>A	uc003wnk.2	+	3	304	c.150G>A	c.(148-150)GCG>GCA	p.A50A	DNAJB6_uc003wnj.2_Silent_p.A50A|DNAJB6_uc003wnl.2_Silent_p.A37A|DNAJB6_uc011kvy.1_Intron|DNAJB6_uc011kvz.1_Silent_p.A50A|DNAJB6_uc010lqt.2_Silent_p.A50A	NM_058246	NP_490647	O75190	DNJB6_HUMAN	DnaJ (Hsp40) homolog, subfamily B, member 6	50	Interaction with HSP70.|J.				intermediate filament organization|negative regulation of caspase activity|protein folding|response to unfolded protein	nucleus|perinuclear region of cytoplasm	ATPase activator activity|chaperone binding|heat shock protein binding|unfolded protein binding			ovary(2)	2	all_neural(206;0.181)	all_epithelial(9;0.000606)|all_hematologic(28;0.00287)|Acute lymphoblastic leukemia(9;0.0647)|Ovarian(593;0.196)	OV - Ovarian serous cystadenocarcinoma(82;0.00399)	UCEC - Uterine corpus endometrioid carcinoma (81;0.172)		AGCAAGTAGCGGAGGCATATG	0.493												
PXDNL	137902	broad.mit.edu	37	8	52321614	52321614	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr8:52321614G>A	uc003xqu.3	-	17	2671	c.2570C>T	c.(2569-2571)GCG>GTG	p.A857V	PXDNL_uc003xqt.3_RNA	NM_144651	NP_653252	A1KZ92	PXDNL_HUMAN	peroxidasin homolog-like precursor	857					hydrogen peroxide catabolic process	extracellular space	heme binding|peroxidase activity			ovary(1)|pancreas(1)	2		all_cancers(86;0.107)|Lung NSC(129;0.00641)|all_epithelial(80;0.00716)|all_lung(136;0.015)				CATGCAGGGCGCGTGGGTGCC	0.682												
SLC10A5	347051	broad.mit.edu	37	8	82606874	82606874	+	Missense_Mutation	SNP	C	C	G			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr8:82606874C>G	uc011lfs.1	-	1	334	c.334G>C	c.(334-336)GAA>CAA	p.E112Q		NM_001010893	NP_001010893	Q5PT55	NTCP5_HUMAN	solute carrier family 10 (sodium/bile acid	112	Extracellular (Potential).					integral to membrane	bile acid:sodium symporter activity				0						ATGAGTCTTTCTTGCCTACCT	0.368												
ZFAT	57623	broad.mit.edu	37	8	135613822	135613822	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr8:135613822C>T	uc003yup.2	-	6	2315	c.2140G>A	c.(2140-2142)GCT>ACT	p.A714T	ZFAT_uc003yun.2_Missense_Mutation_p.A702T|ZFAT_uc003yuo.2_Missense_Mutation_p.A702T|ZFAT_uc010meh.2_Missense_Mutation_p.A702T|ZFAT_uc010mei.2_RNA|ZFAT_uc003yuq.2_Missense_Mutation_p.A702T|ZFAT_uc010mej.2_Missense_Mutation_p.A652T|ZFAT_uc003yur.2_Missense_Mutation_p.A702T	NM_020863	NP_065914	Q9P243	ZFAT_HUMAN	zinc finger protein 406 isoform ZFAT-1	714					regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nucleus	DNA binding|zinc ion binding			central_nervous_system(1)	1	all_epithelial(106;8.26e-19)|Lung NSC(106;3.47e-07)|all_lung(105;1.39e-06)|Ovarian(258;0.0102)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0432)			TTCATGAAAGCGGTGATGCCT	0.542												
PLEC	5339	broad.mit.edu	37	8	144998131	144998131	+	Missense_Mutation	SNP	C	C	T			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr8:144998131C>T	uc003zaf.1	-	31	6547	c.6377G>A	c.(6376-6378)CGC>CAC	p.R2126H	PLEC_uc003zab.1_Missense_Mutation_p.R1989H|PLEC_uc003zac.1_Missense_Mutation_p.R1993H|PLEC_uc003zad.2_Missense_Mutation_p.R1989H|PLEC_uc003zae.1_Missense_Mutation_p.R1957H|PLEC_uc003zag.1_Missense_Mutation_p.R1967H|PLEC_uc003zah.2_Missense_Mutation_p.R1975H|PLEC_uc003zaj.2_Missense_Mutation_p.R2016H	NM_201380	NP_958782	Q15149	PLEC_HUMAN	plectin isoform 1	2126	Central fibrous rod domain.|Potential.				cellular component disassembly involved in apoptosis|hemidesmosome assembly	cytosol|focal adhesion|hemidesmosome|intermediate filament cytoskeleton|sarcolemma	actin binding|structural constituent of muscle|structural constituent of muscle			large_intestine(2)|ovary(2)|pancreas(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|skin(1)	9						CTTCTGCACGCGCTCCTCAGC	0.736												
SMARCA2	6595	broad.mit.edu	37	9	2054682	2054682	+	Missense_Mutation	SNP	G	G	T			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr9:2054682G>T	uc003zhc.2	+	6	1231	c.1132G>T	c.(1132-1134)GTG>TTG	p.V378L	SMARCA2_uc003zhd.2_Missense_Mutation_p.V378L|SMARCA2_uc010mha.2_Missense_Mutation_p.V369L	NM_003070	NP_003061	P51531	SMCA2_HUMAN	SWI/SNF-related matrix-associated	378					chromatin remodeling|negative regulation of cell growth|negative regulation of transcription from RNA polymerase II promoter|nervous system development	intermediate filament cytoskeleton|nBAF complex|npBAF complex|nuclear chromatin|nucleoplasm|SWI/SNF complex|WINAC complex	ATP binding|DNA-dependent ATPase activity|helicase activity|protein binding|RNA polymerase II transcription coactivator activity|transcription regulatory region DNA binding			ovary(2)|central_nervous_system(1)	3		all_lung(10;2.06e-09)|Lung NSC(10;2.43e-09)		GBM - Glioblastoma multiforme(50;0.0475)		CAAAGCAACCGTGGAACTAAA	0.408												
CNTLN	54875	broad.mit.edu	37	9	17416105	17416105	+	Missense_Mutation	SNP	A	A	G			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr9:17416105A>G	uc003zmz.2	+	18	3055	c.3029A>G	c.(3028-3030)GAA>GGA	p.E1010G	CNTLN_uc003zmy.2_Missense_Mutation_p.E1011G|CNTLN_uc010mio.2_Missense_Mutation_p.E690G	NM_017738	NP_060208	Q9NXG0	CNTLN_HUMAN	centlein isoform 1	1011	Potential.					centriole|membrane	two-component sensor activity			pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.14e-10)		TCTGTTAAAGAATATAAAGAA	0.343												
MUSK	4593	broad.mit.edu	37	9	113496549	113496549	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr9:113496549G>A	uc004bey.2	+	6	745	c.647G>A	c.(646-648)CGG>CAG	p.R216Q	MUSK_uc004bex.2_Missense_Mutation_p.R226Q	NM_005592	NP_005583	O15146	MUSK_HUMAN	skeletal muscle receptor tyrosine kinase	216	Ig-like 3.|Extracellular (Potential).				transmembrane receptor protein tyrosine kinase signaling pathway	integral to plasma membrane	ATP binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|ovary(2)|central_nervous_system(1)	6						AGGATCCTGCGGGCTCCTGAA	0.438												
FAM9B	171483	broad.mit.edu	37	X	8998322	8998322	+	Silent	SNP	C	C	T			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chrX:8998322C>T	uc011mhu.1	-	4	350	c.261G>A	c.(259-261)TTG>TTA	p.L87L	FAM9B_uc011mhv.1_RNA|FAM9B_uc004csh.2_Intron	NM_205849	NP_995321	Q8IZU0	FAM9B_HUMAN	family with sequence similarity 9, member B	87						nucleus					0		Hepatocellular(5;0.219)				GCTTTTTTCTCAAAGCATGTT	0.279												
CNKSR2	22866	broad.mit.edu	37	X	21667117	21667117	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chrX:21667117G>A	uc004czx.1	+	21	2897	c.2861G>A	c.(2860-2862)CGG>CAG	p.R954Q	CNKSR2_uc011mjo.1_Missense_Mutation_p.R924Q	NM_014927	NP_055742	Q8WXI2	CNKR2_HUMAN	connector enhancer of kinase suppressor of Ras	954					regulation of signal transduction	cytoplasm|membrane	protein binding			large_intestine(1)|lung(1)	2						AAACTACACCGGCTGAGAATT	0.343												
PCDH11X	27328	broad.mit.edu	37	X	91090690	91090690	+	Missense_Mutation	SNP	T	T	G			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chrX:91090690T>G	uc004efk.1	+	1	1032	c.187T>G	c.(187-189)TTC>GTC	p.F63V	PCDH11X_uc004efl.1_Missense_Mutation_p.F63V|PCDH11X_uc004efo.1_Missense_Mutation_p.F63V|PCDH11X_uc010nmv.1_Missense_Mutation_p.F63V|PCDH11X_uc004efm.1_Missense_Mutation_p.F63V|PCDH11X_uc004efn.1_Missense_Mutation_p.F63V|PCDH11X_uc004efh.1_Missense_Mutation_p.F63V|PCDH11X_uc004efj.1_Missense_Mutation_p.F63V	NM_032968	NP_116750	Q9BZA7	PC11X_HUMAN	protocadherin 11 X-linked isoform c	63	Extracellular (Potential).|Cadherin 1.				homophilic cell adhesion	integral to plasma membrane	calcium ion binding			large_intestine(2)	2						TGCTATGCAGTTCAAGCTAGT	0.453												
TEX13B	56156	broad.mit.edu	37	X	107224569	107224569	+	Missense_Mutation	SNP	G	G	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chrX:107224569G>A	uc004enn.1	-	3	773	c.680C>T	c.(679-681)GCT>GTT	p.A227V		NM_031273	NP_112563	Q9BXU2	TX13B_HUMAN	testis expressed 13B	227										ovary(1)	1						TGCTACAATAGCTCCGAGGGG	0.587												
APBB1IP	54518	broad.mit.edu	37	10	26856151	26856151	+	Frame_Shift_Del	DEL	C	C	-			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr10:26856151delC	uc001iss.2	+	15	2056	c.1735delC	c.(1735-1737)CCCfs	p.P579fs		NM_019043	NP_061916	Q7Z5R6	AB1IP_HUMAN	amyloid beta (A4) precursor protein-binding,	579	Pro-rich.				blood coagulation|signal transduction	cytoskeleton|cytosol|focal adhesion|lamellipodium				lung(4)|skin(2)|central_nervous_system(1)	7						CATGGAGCCGCCCCCAGACTT	0.493												
COQ9	57017	broad.mit.edu	37	16	57481420	57481422	+	In_Frame_Del	DEL	GGC	GGC	-			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr16:57481420_57481422delGGC	uc002elq.2	+	1	19_21	c.3_5delGGC	c.(1-6)ATGGCG>ATG	p.A5del	CIAPIN1_uc002ell.1_5'Flank|CIAPIN1_uc002elm.1_5'Flank|CIAPIN1_uc002eln.1_5'Flank|CIAPIN1_uc010cda.1_5'Flank|CIAPIN1_uc002elo.1_5'Flank|COQ9_uc002elp.1_In_Frame_Del_p.A5del|COQ9_uc010vhn.1_In_Frame_Del_p.A5del|COQ9_uc010vho.1_In_Frame_Del_p.A5del|COQ9_uc010vhp.1_In_Frame_Del_p.A5del|COQ9_uc002elr.2_In_Frame_Del_p.A5del	NM_020312	NP_064708	O75208	COQ9_HUMAN	coenzyme Q9 homolog precursor	5					ubiquinone biosynthetic process	mitochondrion				breast(1)	1						CTTCCAAAATGGCGGCGGCGGCG	0.729												
TP53	7157	broad.mit.edu	37	17	7579442	7579442	+	Frame_Shift_Del	DEL	G	G	-			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr17:7579442delG	uc002gim.2	-	4	439	c.245delC	c.(244-246)CCGfs	p.P82fs	TP53_uc002gig.1_Frame_Shift_Del_p.P82fs|TP53_uc002gih.2_Frame_Shift_Del_p.P82fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_5'Flank|TP53_uc010cng.1_5'Flank|TP53_uc002gii.1_5'Flank|TP53_uc010cnh.1_Frame_Shift_Del_p.P82fs|TP53_uc010cni.1_Frame_Shift_Del_p.P82fs|TP53_uc002gij.2_Frame_Shift_Del_p.P82fs|TP53_uc010cnj.1_5'Flank|TP53_uc002gin.2_Intron|TP53_uc002gio.2_Intron|TP53_uc010vug.1_Frame_Shift_Del_p.P43fs|TP53_uc010cnk.1_Frame_Shift_Del_p.P97fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	82	Interaction with WWOX.|Interaction with HRMT1L2.		P -> L (in LFS; germline mutation and in sporadic cancers; somatic mutation).|P -> S (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.0?(7)|p.P82L(5)|p.A76_S90del15(3)|p.G59fs*23(3)|p.V73fs*9(1)|p.R65fs*38(1)|p.D48fs*55(1)|p.A79_A88del10(1)|p.P82fs*43(1)|p.P13fs*18(1)|p.S33fs*23(1)|p.P82fs*67(1)|p.P82P(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGGGGCCGCCGGTGTAGGAGC	0.607		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumeni_syndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)		
SCN7A	6332	broad.mit.edu	37	2	167322420	167322421	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr2:167322420_167322421insA	uc002udu.1	-	7	868_869	c.741_742insT	c.(739-744)TTTCTGfs	p.F247fs	SCN7A_uc010fpm.1_RNA	NM_002976	NP_002967	Q01118	SCN7A_HUMAN	sodium channel, voltage-gated, type VII, alpha	247_248	Helical; Name=S5 of repeat I; (By similarity).				muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			large_intestine(1)	1						AATATGCTCAGAAAAAACAGAG	0.411												
RNF122	79845	broad.mit.edu	37	8	33416169	33416182	+	Frame_Shift_Del	DEL	AAGACAAAGATGCC	AAGACAAAGATGCC	-			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr8:33416169_33416182delAAGACAAAGATGCC	uc003xjo.1	-	2	535_548	c.133_146delGGCATCTTTGTCTT	c.(133-147)GGCATCTTTGTCTTCfs	p.G45fs		NM_024787	NP_079063	Q9H9V4	RN122_HUMAN	ring finger protein 122	45_49	Helical; (Potential).					endoplasmic reticulum|Golgi apparatus|integral to membrane	zinc ion binding				0				KIRC - Kidney renal clear cell carcinoma(67;0.0966)|Kidney(114;0.116)		GCTGAGCATGAAGACAAAGATGCCTGTGCCGAAG	0.556												
GPR124	25960	broad.mit.edu	37	8	37699349	37699350	+	Frame_Shift_Ins	INS	-	-	G			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr8:37699349_37699350insG	uc003xkj.2	+	19	3856_3857	c.3493_3494insG	c.(3493-3495)CGGfs	p.R1165fs	GPR124_uc010lvy.2_Frame_Shift_Ins_p.R948fs	NM_032777	NP_116166	Q96PE1	GP124_HUMAN	G protein-coupled receptor 124 precursor	1165	Cytoplasmic (Potential).				central nervous system development|endothelial cell migration|neuropeptide signaling pathway|regulation of angiogenesis|regulation of chemotaxis|sprouting angiogenesis	integral to membrane|plasma membrane	G-protein coupled receptor activity			large_intestine(2)|ovary(2)|skin(1)	5			BRCA - Breast invasive adenocarcinoma(5;2.75e-24)|LUSC - Lung squamous cell carcinoma(8;3.5e-10)			GGCGGGCACCCGGGGAAACCTC	0.644												
SCN7A	6332	broad.mit.edu	37	2	167322421	167322422	+	Frame_Shift_Ins	INS	-	-	A			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr2:167322420_167322421G>GA	uc002udu.2	-	6	871_872	c.741_742C>TC	c.(739-744)tttctgfs	p.F247fs	SCN7A_uc010fpm.2_Non-coding_Transcript	NM_002976	NP_002967	Q01118	SCN7A_HUMAN	Homo sapiens sodium channel, voltage-gated, type VII, alpha (SCN7A), transcript variant 1, mRNA.	247					muscle contraction	voltage-gated sodium channel complex	voltage-gated sodium channel activity			breast(1)|endometrium(2)|haematopoietic_and_lymphoid_tissue(2)|kidney(2)|large_intestine(1)|lung(30)|prostate(4)|soft_tissue(1)|urinary_tract(1)	44						AATATGCTCAGAAAAAACAGAG	0.411												
WDFY3	23001	broad.mit.edu	37	4	85675010	85675012	+	In_Frame_Del	DEL	TCT	TCT	-			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr4:85675009_85675011CTCT>C	uc003hpd.3	-	34	5986_5988	c.5578_5580AGAG>G	c.(5578-5580)gag>G	p.E1860del		NM_014991	NP_055806	Q8IZQ1	WDFY3_HUMAN	Homo sapiens WD repeat and FYVE domain containing 3 (WDFY3), mRNA.	1860						cytoplasmic part|extrinsic to membrane|nuclear envelope	1-phosphatidylinositol binding|metal ion binding|protein binding			breast(5)|central_nervous_system(5)|endometrium(15)|haematopoietic_and_lymphoid_tissue(3)|kidney(8)|large_intestine(32)|lung(50)|ovary(3)|prostate(5)|skin(4)|upper_aerodigestive_tract(2)|urinary_tract(2)	134		Hepatocellular(203;0.114)		OV - Ovarian serous cystadenocarcinoma(123;0.000808)		GCCAAGATCCCTCTTCTTCTGAT	0.424												
PCLO	27445	broad.mit.edu	37	7	82595406	82595407	+	Frame_Shift_Ins	INS	-	-	T			TCGA-BR-A4PF-01A-11D-A25D-08	TCGA-BR-A4PF-10A-01D-A25E-08								Untested	Somatic	Phase_I	WXS	none			Illumina GAIIx	25c76e84-85ce-4f2a-b6af-cd7c54621eac	76a41921-d5cb-4385-9294-760aeeae29c2	g.chr7:82595405_82595406C>CT	uc003uhx.2	-	3	3987_3988	c.3698_3699G>AG	c.(3697-3699)aagfs	p.K1233fs	PCLO_uc003uhv.2_Frame_Shift_Ins_p.K1233fs	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	Homo sapiens piccolo (presynaptic cytomatrix protein) (PCLO), transcript variant 1, mRNA.	1172					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			breast(3)|central_nervous_system(3)|cervix(5)|endometrium(19)|haematopoietic_and_lymphoid_tissue(3)|kidney(19)|large_intestine(35)|lung(145)|ovary(7)|prostate(4)|upper_aerodigestive_tract(14)|urinary_tract(2)	259						CTAGGAGTGGCTTTTTTTCTTC	0.386												
