Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
TARDBP	23435	broad.mit.edu	37	1	11080565	11080565	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:11080565G>C	uc001art.2	+	5	757	c.623G>C	c.(622-624)CGG>CCG	p.R208P	TARDBP_uc010oap.1_Missense_Mutation_p.R92P	NM_007375	NP_031401	Q13148	TADBP_HUMAN	TAR DNA binding protein	208	RRM 2.			Missing: Alters but does not abolish RNA binding.	3'-UTR-mediated mRNA stabilization|cell death|mRNA processing|negative regulation by host of viral transcription|RNA splicing|transcription from RNA polymerase II promoter	nucleus	double-stranded DNA binding|mRNA 3'-UTR binding|nucleotide binding|protein binding|sequence-specific DNA binding transcription factor activity			ovary(2)	2	Ovarian(185;0.249)	Lung NSC(185;1.04e-05)|all_lung(284;1.31e-05)|Renal(390;0.000147)|Colorectal(325;0.00205)|Breast(348;0.00262)|Hepatocellular(190;0.00913)|Ovarian(437;0.00965)|Myeloproliferative disorder(586;0.0255)	STAD - Stomach adenocarcinoma(5;0.0578)	UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;3.37e-07)|COAD - Colon adenocarcinoma(227;7.38e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000299)|Kidney(185;0.000754)|KIRC - Kidney renal clear cell carcinoma(229;0.00258)|READ - Rectum adenocarcinoma(331;0.0487)		GATGAGCTGCGGGAGTTCTTC	0.468			NA											4	101					0	0	0.00024832	0	0
CTRC	11330	broad.mit.edu	37	1	15770006	15770006	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:15770006C>G	uc001awi.1	+	5	472	c.449C>G	c.(448-450)CCC>CGC	p.P150R	CTRC_uc001awj.1_Missense_Mutation_p.P150R	NM_007272	NP_009203	Q99895	CTRC_HUMAN	chymotrypsin C preproprotein	150	Peptidase S1.				proteolysis		serine-type endopeptidase activity				0		Breast(348;0.000207)|all_lung(284;0.00021)|Colorectal(325;0.000257)|Lung NSC(340;0.000269)|Renal(390;0.000518)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)|Hepatocellular(190;0.0634)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.56e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|KIRC - Kidney renal clear cell carcinoma(229;0.00244)|STAD - Stomach adenocarcinoma(313;0.0072)|READ - Rectum adenocarcinoma(331;0.0649)		TCCCTGCTCCCCAAGGACTAC	0.582			NA											4	86					0	0	0.00024832	0	0
DNAJC16	23341	broad.mit.edu	37	1	15890493	15890494	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:15890493_15890494GG>TT	uc001aws.2	+	10	1528_1529	c.1408_1409GG>TT	c.(1408-1410)GGG>TTG	p.G470L	DNAJC16_uc001awr.1_Missense_Mutation_p.G470L|DNAJC16_uc001awt.2_Missense_Mutation_p.G158L|DNAJC16_uc001awu.2_RNA	NM_015291	NP_056106	Q9Y2G8	DJC16_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 16	470	Cytoplasmic (Potential).				cell redox homeostasis|protein folding	integral to membrane	heat shock protein binding|unfolded protein binding			urinary_tract(1)|lung(1)|kidney(1)	3		Colorectal(325;0.00108)|Renal(390;0.00145)|Breast(348;0.00173)|all_lung(284;0.00459)|Lung NSC(340;0.00499)|Myeloproliferative disorder(586;0.0393)|Ovarian(437;0.0798)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0228)|Colorectal(212;9.18e-07)|COAD - Colon adenocarcinoma(227;4.5e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000133)|KIRC - Kidney renal clear cell carcinoma(229;0.00262)|STAD - Stomach adenocarcinoma(313;0.00774)|READ - Rectum adenocarcinoma(331;0.0657)		CCCTTGGATTGGGAGTGAGAGT	0.465			NA											9	167					0	0	6.4e-05	0	0
SPEN	23013	broad.mit.edu	37	1	16257949	16257949	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:16257949C>G	uc001axk.1	+	11	5418	c.5214C>G	c.(5212-5214)CCC>CCG	p.P1738P	SPEN_uc010obp.1_Silent_p.P1697P	NM_015001	NP_055816	Q96T58	MINT_HUMAN	spen homolog, transcriptional regulator	1738					interspecies interaction between organisms|negative regulation of transcription, DNA-dependent|Notch signaling pathway	nucleus	nucleotide binding|protein binding|RNA binding			ovary(6)|breast(3)|lung(2)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15		Colorectal(325;0.000258)|Breast(348;0.000278)|Lung NSC(340;0.000419)|Renal(390;0.000518)|all_lung(284;0.000567)|Ovarian(437;0.0129)|Myeloproliferative disorder(586;0.0255)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0185)|Colorectal(212;5.96e-07)|COAD - Colon adenocarcinoma(227;3.11e-05)|BRCA - Breast invasive adenocarcinoma(304;0.000115)|Kidney(64;0.000212)|KIRC - Kidney renal clear cell carcinoma(64;0.003)|STAD - Stomach adenocarcinoma(313;0.013)|READ - Rectum adenocarcinoma(331;0.0681)		CTCCAACTCCCGGGGCCTCGT	0.562			NA											4	176					0	0	1.23904e-05	0	0
CLIC4	25932	broad.mit.edu	37	1	25167381	25167381	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:25167381G>T	uc001bjo.2	+	6	1000	c.715G>T	c.(715-717)GAG>TAG	p.E239*	CLIC4_uc001bjn.2_RNA|CLIC4_uc001bjp.1_Nonsense_Mutation_p.E219*	NM_013943	NP_039234	Q9Y696	CLIC4_HUMAN	chloride intracellular channel 4	239	GST C-terminal.				cellular response to calcium ion|establishment or maintenance of apical/basal cell polarity|keratinocyte differentiation|negative regulation of cell migration|regulation of cytoskeleton organization	actin cytoskeleton|apical part of cell|cell surface|cell-cell junction|centrosome|chloride channel complex|cytoplasmic vesicle membrane|cytosol|microvillus|midbody|mitochondrion|nuclear matrix|perinuclear region of cytoplasm|soluble fraction	voltage-gated chloride channel activity				0		Colorectal(325;3.46e-05)|Renal(390;0.0007)|Lung NSC(340;0.000778)|all_lung(284;0.00106)|Ovarian(437;0.00764)|Breast(348;0.0148)|Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0936)		UCEC - Uterine corpus endometrioid carcinoma (279;0.0479)|OV - Ovarian serous cystadenocarcinoma(117;1.06e-24)|Colorectal(126;1.03e-07)|COAD - Colon adenocarcinoma(152;4.93e-06)|STAD - Stomach adenocarcinoma(196;0.000418)|GBM - Glioblastoma multiforme(114;0.000451)|BRCA - Breast invasive adenocarcinoma(304;0.00215)|KIRC - Kidney renal clear cell carcinoma(1967;0.00216)|READ - Rectum adenocarcinoma(331;0.0693)|Lung(427;0.0853)|LUSC - Lung squamous cell carcinoma(448;0.18)		CAGTGATAAGGAGGTTGAAAT	0.398			NA											34	20					3.90053e-15	9.28568e-14	0.000409698	1	0
KPNA6	23633	broad.mit.edu	37	1	32636463	32636463	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:32636463C>T	uc001bug.2	+	14	1667	c.1579C>T	c.(1579-1581)CCT>TCT	p.P527S	KPNA6_uc001buh.2_Missense_Mutation_p.P302S|KPNA6_uc010ogx.1_Missense_Mutation_p.P524S|KPNA6_uc010ogy.1_Missense_Mutation_p.P532S|KPNA6_uc009vtz.2_Missense_Mutation_p.P422S	NM_012316	NP_036448	O60684	IMA7_HUMAN	karyopherin alpha 6	527					NLS-bearing substrate import into nucleus	cytoplasm|nuclear pore	protein binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				CTTCCAGCAGCCTGAGGCCCC	0.582			NA											34	39					0	0	0.000109025	0	0
LCK	3932	broad.mit.edu	37	1	32745271	32745271	+	Splice_Site	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:32745271G>C	uc001bux.2	+	10	1103	c.965_splice	c.e10-1	p.G322_splice	LCK_uc001buy.2_Splice_Site_p.G322_splice|LCK_uc001buz.2_Missense_Mutation_p.G352R|LCK_uc010ohc.1_Splice_Site_p.G366_splice|LCK_uc001bva.2_Splice_Site_p.G329_splice	NM_005356	NP_005347	P06239	LCK_HUMAN	lymphocyte-specific protein tyrosine kinase						activation of caspase activity|cellular zinc ion homeostasis|induction of apoptosis|interspecies interaction between organisms|leukocyte migration|platelet activation|positive regulation of T cell receptor signaling pathway|regulation of defense response to virus by virus|release of sequestered calcium ion into cytosol|response to drug|T cell costimulation|T cell differentiation|T cell receptor signaling pathway|viral reproduction	cytosol|Golgi apparatus|membrane raft|pericentriolar material|plasma membrane	ATP binding|ATPase binding|CD4 receptor binding|CD8 receptor binding|glycoprotein binding|non-membrane spanning protein tyrosine kinase activity|phosphatidylinositol 3-kinase binding|protein C-terminus binding|protein kinase binding|protein serine/threonine phosphatase activity|SH2 domain binding			lung(3)|central_nervous_system(2)|ovary(1)	6		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.212)			Dasatinib(DB01254)	TCTGCCCACAGGGAGTCTAGT	0.562			NA	T	TRB@	T-ALL								5	207					0	0	1.23904e-05	0	0
PPT1	5538	broad.mit.edu	37	1	40562846	40562846	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:40562846C>G	uc001cfb.2	-	1	297	c.65G>C	c.(64-66)CGG>CCG	p.R22P	PPT1_uc010ojg.1_Missense_Mutation_p.R22P|PPT1_uc009vwa.2_RNA	NM_000310	NP_000301	P50897	PPT1_HUMAN	palmitoyl-protein thioesterase 1 isoform 1	22					brain development|cofactor metabolic process|cofactor transport|DNA fragmentation involved in apoptotic nuclear change|lysosomal lumen acidification|membrane raft organization|negative regulation of cell growth|negative regulation of neuron apoptosis|neuron development|pinocytosis|positive regulation of pinocytosis|positive regulation of receptor-mediated endocytosis|protein depalmitoylation|protein transport|receptor-mediated endocytosis|regulation of synapse structure and activity|sphingolipid catabolic process|visual perception	axon|cytosol|Golgi apparatus|lysosome|membrane fraction|membrane raft|nucleus|synaptic vesicle	palmitoyl-(protein) hydrolase activity|palmitoyl-CoA hydrolase activity			ovary(1)	1	Lung NSC(20;3.43e-06)|Ovarian(52;0.00167)|all_hematologic(146;0.0501)|Acute lymphoblastic leukemia(166;0.074)	Myeloproliferative disorder(586;0.0255)	OV - Ovarian serous cystadenocarcinoma(33;1e-18)|Epithelial(16;3.6e-17)|all cancers(16;1.1e-15)|LUSC - Lung squamous cell carcinoma(16;0.00146)|Lung(16;0.00204)			CTGCAGCGCCCGAGAAGCGCA	0.632			NA											4	163					0	0	0.00024832	0	0
HIVEP3	59269	broad.mit.edu	37	1	41979091	41979091	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:41979091T>C	uc001cgz.3	-	8	7014	c.5801A>G	c.(5800-5802)CAG>CGG	p.Q1934R	HIVEP3_uc001cha.3_Missense_Mutation_p.Q1934R|HIVEP3_uc001cgy.2_RNA	NM_024503	NP_078779	Q5T1R4	ZEP3_HUMAN	human immunodeficiency virus type I enhancer	1934	Ser-rich.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	zinc ion binding			ovary(4)|large_intestine(1)|central_nervous_system(1)	6	Ovarian(52;0.00769)|all_hematologic(146;0.109)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0367)				CGGCATGCTCTGGCTGGACAT	0.662			NA											11	7					0	0	6.40141e-05	0	0
TIE1	7075	broad.mit.edu	37	1	43778157	43778157	+	Silent	SNP	T	T	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:43778157T>A	uc001ciu.2	+	12	1891	c.1812T>A	c.(1810-1812)ACT>ACA	p.T604T	TIE1_uc010okd.1_Silent_p.T604T|TIE1_uc010oke.1_Silent_p.T559T|TIE1_uc009vwq.2_Silent_p.T560T|TIE1_uc010okf.1_Silent_p.T249T|TIE1_uc010okg.1_Silent_p.T249T	NM_005424	NP_005415	P35590	TIE1_HUMAN	tyrosine kinase with immunoglobulin-like and	604	Fibronectin type-III 2.|Extracellular (Potential).				mesoderm development	integral to plasma membrane	ATP binding|protein binding|transmembrane receptor protein tyrosine kinase activity			lung(3)|stomach(1)|salivary_gland(1)|ovary(1)|skin(1)	7	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				AGGCCCGCACTGCCCTCCTGA	0.716			NA											9	19					0	0	0.000274275	0	0
MPL	4352	broad.mit.edu	37	1	43812251	43812251	+	Silent	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:43812251G>C	uc001ciw.2	+	7	1161	c.1116G>C	c.(1114-1116)CCG>CCC	p.P372P	MPL_uc001civ.2_Silent_p.P372P|MPL_uc009vwr.2_Silent_p.P365P	NM_005373	NP_005364	P40238	TPOR_HUMAN	myeloproliferative leukemia virus oncogene	372	Extracellular (Potential).				cell proliferation|platelet activation	integral to plasma membrane	cytokine receptor activity			haematopoietic_and_lymphoid_tissue(361)|upper_aerodigestive_tract(1)|pancreas(1)	363	all_hematologic(146;0.0958)|Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0505)				CCACAGCCCCGGGTACTGTTC	0.512	NSCLC(52;534 1204 10016 41452 44427)		NA	Mis		MPD	MPD	congenital amegakaryocytic thrombocytopenia						5	174					0	0	1.23904e-05	0	0
DPH2	1802	broad.mit.edu	37	1	44437603	44437603	+	Silent	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:44437603G>C	uc001ckz.2	+	4	1224	c.1029G>C	c.(1027-1029)CTG>CTC	p.L343L	DPH2_uc001cla.2_Intron|DPH2_uc010okk.1_Silent_p.L208L|DPH2_uc001clb.2_Silent_p.L267L|ATP6V0B_uc001clc.2_5'Flank|ATP6V0B_uc001cld.2_5'Flank|ATP6V0B_uc001cle.2_5'Flank	NM_001384	NP_001375	Q9BQC3	DPH2_HUMAN	diphthamide biosynthesis protein 2 isoform a	343					peptidyl-diphthamide biosynthetic process from peptidyl-histidine	cytoplasm				ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)	Myeloproliferative disorder(586;0.0511)				CCTGTCCTCTGGGTGCTCTAG	0.607			NA											5	149					0	0	8.12818e-05	0	0
EIF2B3	8891	broad.mit.edu	37	1	45340362	45340362	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:45340362G>C	uc001cmt.1	-	10	1317	c.1190C>G	c.(1189-1191)ACT>AGT	p.T397S	EIF2B3_uc001cmu.1_Missense_Mutation_p.T397S|EIF2B3_uc001cmv.1_Missense_Mutation_p.T371S|EIF2B3_uc001cmw.2_Missense_Mutation_p.T397S	NM_020365	NP_065098	Q9NR50	EI2BG_HUMAN	eukaryotic translation initiation factor 2B,	397					negative regulation of translational initiation in response to stress|oligodendrocyte development|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	nucleotidyltransferase activity|protein binding|translation initiation factor activity			ovary(1)	1	Acute lymphoblastic leukemia(166;0.155)					TTCCTCCACAGTGACTGAGTT	0.294	Colon(26;357 658 2581 11857 12657)		NA											50	74					0	0	0.000147903	0	0
MAST2	23139	broad.mit.edu	37	1	46487708	46487709	+	Missense_Mutation	DNP	CC	CC	GA			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:46487708_46487709CC>GA	uc001cov.2	+	12	1660_1661	c.1377_1378CC>GA	c.(1375-1380)CCCCGC>CCGAGC	p.R460S	MAST2_uc001cow.2_Missense_Mutation_p.R460S|MAST2_uc001coy.1_Missense_Mutation_p.R134S|MAST2_uc001coz.1_Missense_Mutation_p.R345S|MAST2_uc009vya.2_Missense_Mutation_p.R382S|MAST2_uc001cpa.2_RNA	NM_015112	NP_055927	Q6P0Q8	MAST2_HUMAN	microtubule associated serine/threonine kinase	460					regulation of interleukin-12 biosynthetic process|spermatid differentiation	cytoplasm|cytoskeleton|plasma membrane	ATP binding|magnesium ion binding|phosphatase binding|protein serine/threonine kinase activity			ovary(5)|lung(3)|stomach(2)|breast(1)	11	Acute lymphoblastic leukemia(166;0.155)|Lung SC(450;0.184)					GTGACATTCCCCGCTACATCGT	0.559			NA											4	101					0	0	6.4e-05	0	0
CYP4A11	1579	broad.mit.edu	37	1	47398483	47398483	+	Silent	SNP	C	C	G	rs9333059	byFrequency	TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:47398483C>G	uc001cqp.3	-	11	1365	c.1314G>C	c.(1312-1314)CCG>CCC	p.P438P	CYP4A11_uc001cqq.2_Silent_p.P438P	NM_000778	NP_000769	Q02928	CP4AB_HUMAN	cytochrome P450, family 4, subfamily A,	438					long-chain fatty acid metabolic process|xenobiotic metabolic process	endoplasmic reticulum membrane|microsome	alkane 1-monooxygenase activity|electron carrier activity|heme binding|oxygen binding			ovary(2)|skin(2)	4					NADH(DB00157)	GAGCAGAACCCGGTGCAAAAC	0.542			NA											7	249					0	0	0.000157383	0	0
FGGY	55277	broad.mit.edu	37	1	59787238	59787238	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:59787238A>T	uc001czi.3	+	2	229	c.17A>T	c.(16-18)CAG>CTG	p.Q6L	FGGY_uc001czg.2_5'UTR|FGGY_uc001czh.2_RNA|FGGY_uc009wac.2_Missense_Mutation_p.Q6L|FGGY_uc001czj.3_Missense_Mutation_p.Q6L|FGGY_uc001czk.3_Intron|FGGY_uc001czl.3_Missense_Mutation_p.Q6L	NM_018291	NP_060761	Q96C11	FGGY_HUMAN	FGGY carbohydrate kinase domain containing	6					carbohydrate metabolic process|cell death|neuron homeostasis		kinase activity|phosphotransferase activity, alcohol group as acceptor			ovary(1)	1	all_cancers(7;7.36e-05)					GGTGGAGAACAGAAACCAGAG	0.493			NA											17	52					0	0	0.000229342	0	0
DOCK7	85440	broad.mit.edu	37	1	62960067	62960067	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:62960067G>T	uc001daq.2	-	40	5103	c.5069C>A	c.(5068-5070)TCA>TAA	p.S1690*	DOCK7_uc001dan.2_Nonsense_Mutation_p.S1551*|DOCK7_uc001dao.2_Nonsense_Mutation_p.S1551*|DOCK7_uc001dap.2_Nonsense_Mutation_p.S1668*|DOCK7_uc001dam.2_Nonsense_Mutation_p.S870*|DOCK7_uc010oov.1_Nonsense_Mutation_p.S429*	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1699	DHR-2.				activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						GCTTCGTTCTGAGTGCTTGCC	0.463			NA											14	705					0.000308642	0.00625466	0.000308642	1	0
DOCK7	85440	broad.mit.edu	37	1	63008322	63008322	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:63008322C>G	uc001daq.2	-	25	3036	c.3002G>C	c.(3001-3003)CGG>CCG	p.R1001P	DOCK7_uc001dan.2_Missense_Mutation_p.R862P|DOCK7_uc001dao.2_Missense_Mutation_p.R862P|DOCK7_uc001dap.2_Missense_Mutation_p.R970P|DOCK7_uc001dam.2_Missense_Mutation_p.R181P	NM_033407	NP_212132	Q96N67	DOCK7_HUMAN	dedicator of cytokinesis 7	1001					activation of Rac GTPase activity|axonogenesis|establishment of neuroblast polarity|microtubule cytoskeleton organization|positive regulation of peptidyl-serine phosphorylation	axon|basal part of cell|growth cone	GTP binding|guanyl-nucleotide exchange factor activity|Rac GTPase binding			ovary(2)	2						AGCTGATTCCCGAACGCTGCC	0.378			NA											4	94					0	0	1.23904e-05	0	0
IL12RB2	3595	broad.mit.edu	37	1	67852300	67852300	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:67852300T>A	uc001ddu.2	+	14	2534	c.1894T>A	c.(1894-1896)TGC>AGC	p.C632S	IL12RB2_uc010oqi.1_Missense_Mutation_p.C632S|IL12RB2_uc010oqj.1_Missense_Mutation_p.C632S|IL12RB2_uc010oqk.1_RNA|IL12RB2_uc010oql.1_Missense_Mutation_p.C546S|IL12RB2_uc010oqm.1_Intron|IL12RB2_uc010oqn.1_Intron	NM_001559	NP_001550	Q99665	I12R2_HUMAN	interleukin 12 receptor, beta 2 precursor	632	Helical; (Potential).				positive regulation of cell proliferation|positive regulation of interferon-gamma production	integral to plasma membrane	cytokine receptor activity			ovary(2)|central_nervous_system(1)	3						ACCAAGCATTTGCATTGCTAT	0.338			NA											56	36					0	0	0.000147903	0	0
SLC44A5	204962	broad.mit.edu	37	1	75684360	75684360	+	Silent	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:75684360C>T	uc001dgu.2	-	17	1488	c.1344G>A	c.(1342-1344)TTG>TTA	p.L448L	SLC44A5_uc001dgt.2_Silent_p.L448L|SLC44A5_uc001dgs.2_Silent_p.L406L|SLC44A5_uc001dgr.2_Silent_p.L406L|SLC44A5_uc010oqz.1_Silent_p.L487L|SLC44A5_uc010ora.1_Silent_p.L442L|SLC44A5_uc010orb.1_Silent_p.L318L	NM_152697	NP_689910	Q8NCS7	CTL5_HUMAN	solute carrier family 44, member 5 isoform A	448	Cytoplasmic (Potential).					integral to membrane|plasma membrane	choline transmembrane transporter activity			ovary(2)|skin(2)	4						ACTGATGGTACAAGCTCTTTC	0.418			NA											20	12					0	0	0.000229342	0	0
NEXN	91624	broad.mit.edu	37	1	78383891	78383891	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:78383891G>A	uc001dic.3	+	5	677	c.380G>A	c.(379-381)CGC>CAC	p.R127H	NEXN_uc001dia.3_Missense_Mutation_p.R127H|NEXN_uc009wcb.1_Missense_Mutation_p.R63H|NEXN_uc001dib.3_Missense_Mutation_p.R63H|NEXN_uc001did.1_Missense_Mutation_p.R51H|NEXN_uc001dif.1_Missense_Mutation_p.R19H	NM_144573	NP_653174	Q0ZGT2	NEXN_HUMAN	nexilin (F actin binding protein)	127	Glu-rich.				regulation of cell migration|regulation of cytoskeleton organization	cytoskeleton|Z disc	actin filament binding|structural constituent of muscle			ovary(2)	2				Colorectal(170;0.114)		GAACGAAAACGCAGAATTGAG	0.368			NA											34	53					0	0	8.91981e-05	0	0
ELTD1	64123	broad.mit.edu	37	1	79404935	79404935	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:79404935T>C	uc001diq.3	-	4	490	c.334A>G	c.(334-336)AAT>GAT	p.N112D		NM_022159	NP_071442	Q9HBW9	ELTD1_HUMAN	EGF, latrophilin and seven transmembrane domain	112	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	calcium ion binding|G-protein coupled receptor activity			ovary(1)|skin(1)	2				COAD - Colon adenocarcinoma(225;0.0905)|Colorectal(170;0.103)|all cancers(265;0.105)|Epithelial(280;0.148)		CAGTTTGCATTCACATTTTCT	0.249			NA											6	64					0	0	0.000157383	0	0
SSX2IP	117178	broad.mit.edu	37	1	85124125	85124125	+	Silent	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:85124125G>A	uc001dkh.2	-	10	1229	c.954C>T	c.(952-954)GCC>GCT	p.A318A	SSX2IP_uc001dkf.2_Silent_p.A291A|SSX2IP_uc001dkg.2_RNA|SSX2IP_uc010orz.1_Silent_p.A291A|SSX2IP_uc001dki.2_Silent_p.A318A|SSX2IP_uc010osa.1_Silent_p.A291A|SSX2IP_uc001dkj.2_Silent_p.A318A|SSX2IP_uc009wci.2_Intron|SSX2IP_uc001dkk.1_Silent_p.A314A	NM_014021	NP_054740	Q9Y2D8	ADIP_HUMAN	synovial sarcoma, X breakpoint 2 interacting	318					cell adhesion	nucleus|protein complex				ovary(2)	2				all cancers(265;0.0053)|Epithelial(280;0.0214)|OV - Ovarian serous cystadenocarcinoma(397;0.173)		TTAGTTCCCCGGCATCTTCTT	0.443			NA											22	14					0	0	0.000229342	0	0
PKN2	5586	broad.mit.edu	37	1	89273449	89273449	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:89273449A>T	uc001dmn.2	+	15	2435	c.2093A>T	c.(2092-2094)GAA>GTA	p.E698V	PKN2_uc010osp.1_Missense_Mutation_p.E682V|PKN2_uc010osq.1_Missense_Mutation_p.E541V|PKN2_uc009wcv.2_Missense_Mutation_p.E650V|PKN2_uc010osr.1_Missense_Mutation_p.E363V	NM_006256	NP_006247	Q16513	PKN2_HUMAN	protein kinase N2	698	Protein kinase.				signal transduction	cytoplasm	ATP binding|histone deacetylase binding|protein kinase C activity			large_intestine(1)|lung(1)|skin(1)	3		Lung NSC(277;0.123)		all cancers(265;0.0136)|Epithelial(280;0.0301)		GCTCGAGATGAAGTAGACAGG	0.259			NA											71	60					0	0	0.000147903	0	0
BARHL2	343472	broad.mit.edu	37	1	91180292	91180292	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:91180292C>G	uc001dns.2	-	2	689	c.647G>C	c.(646-648)CGG>CCG	p.R216P		NM_020063	NP_064447	Q9NY43	BARH2_HUMAN	BarH-like homeobox 2	216						nucleus	sequence-specific DNA binding			ovary(1)	1		all_lung(203;0.0263)|Lung SC(238;0.128)		all cancers(265;0.000897)|Epithelial(280;0.00516)|OV - Ovarian serous cystadenocarcinoma(397;0.211)		CGTAATCTCCCGGTCTCCTTC	0.542	GBM(199;3561 4100 22440)		NA											8	221					0	0	0.000157383	0	0
CDC7	8317	broad.mit.edu	37	1	91967324	91967325	+	Missense_Mutation	DNP	CC	CC	GA			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:91967324_91967325CC>GA	uc001doe.2	+	2	216_217	c.51_52CC>GA	c.(49-54)CCCCAG>CCGAAG	p.Q18K	CDC7_uc001dof.2_Missense_Mutation_p.Q18K|CDC7_uc010osw.1_Missense_Mutation_p.Q18K|CDC7_uc009wdc.2_Missense_Mutation_p.Q18K	NM_003503	NP_003494	O00311	CDC7_HUMAN	cell division cycle 7	18					cell cycle checkpoint|cell division|DNA replication|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|positive regulation of cell proliferation|regulation of S phase	cytoplasm|nucleoplasm	ATP binding|metal ion binding|protein binding|protein serine/threonine kinase activity			stomach(2)|large_intestine(1)|ovary(1)|central_nervous_system(1)	5		all_lung(203;0.0165)|Lung NSC(277;0.0562)		all cancers(265;0.00108)|Epithelial(280;0.0184)|KIRC - Kidney renal clear cell carcinoma(1967;0.124)		CTTTTTCTCCCCAGCGTGACCG	0.436			NA											7	486					0	0	6.4e-05	0	0
EVI5	7813	broad.mit.edu	37	1	93202138	93202138	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:93202138C>G	uc001dox.2	-	2	108	c.98G>C	c.(97-99)TGG>TCG	p.W33S	EVI5_uc010otf.1_Missense_Mutation_p.W33S	NM_005665	NP_005656	O60447	EVI5_HUMAN	ecotropic viral integration site 5	33	Interaction with alpha-tubulin, gamma- tubulin, BIRC5 and FBXO5.|Ser-rich.				cell cycle|cell division|cell proliferation|multicellular organismal development	microtubule organizing center|nucleus|spindle	protein binding|Rab GTPase activator activity			ovary(1)|breast(1)	2		all_lung(203;0.00146)|Lung NSC(277;0.00565)|all_neural(321;0.185)|Melanoma(281;0.193)|Glioma(108;0.203)		Epithelial(280;8.09e-25)|OV - Ovarian serous cystadenocarcinoma(397;1.27e-22)|all cancers(265;1.74e-21)|GBM - Glioblastoma multiforme(16;0.00233)|BRCA - Breast invasive adenocarcinoma(282;0.211)		GTTCTTCACCCATGAGAGAGT	0.423			NA											5	168					0	0	0.000157383	0	0
FNBP1L	54874	broad.mit.edu	37	1	94014920	94014920	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:94014920G>A	uc001dpw.2	+	13	1414	c.1414G>A	c.(1414-1416)GAA>AAA	p.E472K	FNBP1L_uc001dpv.2_Missense_Mutation_p.E472K|FNBP1L_uc010otk.1_Missense_Mutation_p.E350K|FNBP1L_uc010otl.1_Missense_Mutation_p.E100K	NM_001024948	NP_001020119	Q5T0N5	FBP1L_HUMAN	formin binding protein 1-like isoform 1	530	Interaction with DNM1.|Interaction with CDC42.				endocytosis	cell cortex|cytoplasmic membrane-bounded vesicle|cytoskeleton|plasma membrane	lipid binding				0		all_lung(203;0.00206)|Lung NSC(277;0.00902)|Melanoma(281;0.155)		all cancers(265;0.00666)|GBM - Glioblastoma multiforme(16;0.0378)|Epithelial(280;0.111)		GTTTGATGATGAATTTGAGGA	0.393			NA											113	39					0	0	0.000147903	0	0
DNTTIP2	30836	broad.mit.edu	37	1	94342244	94342245	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:94342244_94342245CC>AA	uc001dqf.2	-	2	1284_1285	c.1246_1247GG>TT	c.(1246-1248)GGG>TTG	p.G416L	DNTTIP2_uc010otm.1_RNA|DNTTIP2_uc009wdo.1_Missense_Mutation_p.G211L	NM_014597	NP_055412	Q5QJE6	TDIF2_HUMAN	deoxynucleotidyltransferase, terminal,	416					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_lung(203;0.0111)|Lung NSC(277;0.0347)		all cancers(265;0.00679)|GBM - Glioblastoma multiforme(16;0.0278)|Epithelial(280;0.128)		ATCTACATTCCCTTCACTGTTC	0.396			NA											18	683					0	0	6.4e-05	0	0
ABCD3	5825	broad.mit.edu	37	1	94933551	94933551	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:94933551C>T	uc001dqn.3	+	4	425	c.323C>T	c.(322-324)ACA>ATA	p.T108I	ABCD3_uc001dqm.3_Missense_Mutation_p.T108I|ABCD3_uc010oto.1_Missense_Mutation_p.T132I|ABCD3_uc010otp.1_Missense_Mutation_p.T35I|ABCD3_uc009wdr.2_Missense_Mutation_p.T108I	NM_002858	NP_002849	P28288	ABCD3_HUMAN	ATP-binding cassette, sub-family D, member 3	108	ABC transmembrane type-1.|Targeting to peroxisomes.|Interaction with PEX19.				peroxisomal long-chain fatty acid import|peroxisome organization	cytosol|integral to peroxisomal membrane	ATP binding|ATPase activity, coupled to transmembrane movement of substances			skin(1)	1		all_lung(203;0.000434)|Lung NSC(277;0.0019)		all cancers(265;0.0261)|Epithelial(280;0.165)		CAAAATGGGACACTAATTGAA	0.313			NA											18	108					0	0	0.000229342	0	0
COL11A1	1301	broad.mit.edu	37	1	103483430	103483430	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:103483430C>G	uc001dul.2	-	11	1677	c.1359G>C	c.(1357-1359)ATG>ATC	p.M453I	COL11A1_uc001duk.2_5'UTR|COL11A1_uc001dum.2_Missense_Mutation_p.M465I|COL11A1_uc001dun.2_Missense_Mutation_p.M414I|COL11A1_uc009weh.2_Missense_Mutation_p.M337I	NM_001854	NP_001845	P12107	COBA1_HUMAN	alpha 1 type XI collagen isoform A	453	Triple-helical region (interrupted).				collagen fibril organization|detection of mechanical stimulus involved in sensory perception of sound|visual perception	collagen type XI	extracellular matrix binding|extracellular matrix structural constituent|protein binding, bridging			ovary(6)|breast(3)|upper_aerodigestive_tract(1)|central_nervous_system(1)|pancreas(1)	12		all_epithelial(167;2.52e-07)|all_lung(203;3.11e-05)|Lung NSC(277;6.61e-05)|Breast(1374;0.181)		Lung(183;0.186)|all cancers(265;0.242)|Epithelial(280;0.248)		CTGGAGGACCCATAATACCCT	0.413			NA											5	156					0	0	3.59834e-05	0	0
AMY2A	279	broad.mit.edu	37	1	104160136	104160136	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:104160136G>C	uc001dut.2	+	1	138	c.74G>C	c.(73-75)CGG>CCG	p.R25P	AMY2A_uc010ouq.1_Missense_Mutation_p.R25P	NM_000699	NP_000690	P04746	AMYP_HUMAN	pancreatic amylase alpha 2A precursor	25					carbohydrate catabolic process|polysaccharide digestion	extracellular space	alpha-amylase activity|calcium ion binding|chloride ion binding			ovary(1)|skin(1)	2		all_epithelial(167;3.05e-05)|all_lung(203;0.000199)|Lung NSC(277;0.000451)		Colorectal(144;0.0654)|all cancers(265;0.0808)|Epithelial(280;0.0921)|Lung(183;0.111)	Acarbose(DB00284)|Bentiromide(DB00522)|Icodextrin(DB00702)|Miglitol(DB00491)|Pancrelipase(DB00085)	CAACAAGGACGGACATCTATT	0.438			NA											7	390					0	0	0.000442599	0	0
C1orf194	127003	broad.mit.edu	37	1	109650640	109650640	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:109650640G>T	uc009wev.2	-	2	169	c.101C>A	c.(100-102)CCA>CAA	p.P34Q	C1orf194_uc001dwp.3_Intron|C1orf194_uc009wew.2_Missense_Mutation_p.P22Q	NM_001122961	NP_001116433	Q5T5A4	CA194_HUMAN	hypothetical protein LOC127003	34										ovary(1)	1						AAGGTGTGTTGGGTTCTTATA	0.498			NA											9	172					6.40141e-05	0.00135931	6.40141e-05	1	0
KCND3	3752	broad.mit.edu	37	1	112524907	112524907	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:112524907T>A	uc001ebu.1	-	2	922	c.442A>T	c.(442-444)ATG>TTG	p.M148L	KCND3_uc001ebv.1_Missense_Mutation_p.M148L	NM_004980	NP_004971	Q9UK17	KCND3_HUMAN	potassium voltage-gated channel, Shal-related	148	Cytoplasmic (Potential).					sarcolemma|voltage-gated potassium channel complex	A-type (transient outward) potassium channel activity|metal ion binding			ovary(2)|large_intestine(1)	3		all_cancers(81;8.52e-06)|all_epithelial(167;5.65e-06)|all_lung(203;2.72e-05)|Lung NSC(69;4.56e-05)		all cancers(265;0.056)|Lung(183;0.0576)|Colorectal(144;0.1)|Epithelial(280;0.104)|COAD - Colon adenocarcinoma(174;0.222)|LUSC - Lung squamous cell carcinoma(189;0.231)		TTGTCGTCCATGAGCCGCTCG	0.632			NA											9	16					0	0	0.000274275	0	0
SLC16A1	6566	broad.mit.edu	37	1	113464670	113464670	+	Silent	SNP	A	A	T	rs148691598	byFrequency	TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:113464670A>T	uc001ecx.2	-	3	1135	c.303T>A	c.(301-303)ATT>ATA	p.I101I	SLC16A1_uc001ecy.2_Silent_p.I101I|SLC16A1_uc001ecz.2_Silent_p.I101I|AFARP1_uc001eda.1_5'Flank	NM_003051	NP_003042	P53985	MOT1_HUMAN	solute carrier family 16, member 1	101	Helical; (Potential).				blood coagulation|leukocyte migration|organic anion transport|pyruvate metabolic process	integral to membrane|membrane fraction|plasma membrane	mevalonate transmembrane transporter activity|protein binding|secondary active monocarboxylate transmembrane transporter activity|symporter activity			central_nervous_system(1)	1	Lung SC(450;0.246)	all_cancers(81;7.6e-08)|all_epithelial(167;3.82e-07)|all_lung(203;3.07e-05)|Lung NSC(69;5.51e-05)|Prostate(1639;0.00232)		Epithelial(280;7.31e-13)|all cancers(265;5.1e-10)|Kidney(133;5.29e-07)|KIRC - Kidney renal clear cell carcinoma(1967;8.63e-06)|OV - Ovarian serous cystadenocarcinoma(397;1.48e-05)|BRCA - Breast invasive adenocarcinoma(282;0.003)|LUSC - Lung squamous cell carcinoma(189;0.008)|Lung(183;0.00948)|Colorectal(144;0.0325)|COAD - Colon adenocarcinoma(174;0.0643)	Pyruvic acid(DB00119)	AAGAAGCTGCAATCAAGCCAC	0.418			NA											25	30					0	0	0.00047179	0	0
VANGL1	81839	broad.mit.edu	37	1	116206619	116206619	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:116206619G>C	uc001efv.1	+	4	813	c.542G>C	c.(541-543)CGG>CCG	p.R181P	VANGL1_uc009wgy.1_Missense_Mutation_p.R179P|VANGL1_uc001efw.1_Missense_Mutation_p.R181P	NM_138959	NP_620409	Q8TAA9	VANG1_HUMAN	vang-like 1	181	Cytoplasmic (Potential).		R -> Q (in NTD; uncertain pathogenicity).		multicellular organismal development	integral to membrane	protein binding			central_nervous_system(1)	1	Lung SC(450;0.211)	all_cancers(81;1.24e-06)|all_epithelial(167;1.02e-06)|all_lung(203;7.95e-06)|Lung NSC(69;4.97e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		GACATGCCACGGGTGTTTGTG	0.498			NA											10	477					0	0	0.000219431	0	0
SLC22A15	55356	broad.mit.edu	37	1	116605429	116605430	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:116605429_116605430GG>TT	uc001egb.3	+	9	1348_1349	c.1218_1219GG>TT	c.(1216-1221)CTGGGG>CTTTGG	p.G407W		NM_018420	NP_060890	Q8IZD6	S22AF_HUMAN	solute carrier family 22, member 15	407	Helical; (Potential).				ion transport	integral to membrane	transmembrane transporter activity			large_intestine(2)	2	Lung SC(450;0.184)	all_cancers(81;3.17e-06)|all_epithelial(167;2.32e-06)|all_lung(203;9.81e-06)|Lung NSC(69;5.94e-05)		Lung(183;0.0171)|Colorectal(144;0.0686)|LUSC - Lung squamous cell carcinoma(189;0.0903)|all cancers(265;0.108)|COAD - Colon adenocarcinoma(174;0.111)|Epithelial(280;0.12)		TGTCCTTGCTGGGGAAGCTGAC	0.48			NA											16	519					0	0	6.4e-05	0	0
HMGCS2	3158	broad.mit.edu	37	1	120298101	120298102	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:120298101_120298102CC>AA	uc001eid.2	-	6	1186_1187	c.1135_1136GG>TT	c.(1135-1137)GGG>TTG	p.G379L	HMGCS2_uc010oxj.1_Missense_Mutation_p.G337L|HMGCS2_uc001eie.2_Missense_Mutation_p.G287L	NM_005518	NP_005509	P54868	HMCS2_HUMAN	hydroxymethylglutaryl-CoA synthase 2 isoform 1	379					acetoacetic acid biosynthetic process|cholesterol biosynthetic process|isoprenoid biosynthetic process|ketone body biosynthetic process	mitochondrial matrix	hydroxymethylglutaryl-CoA synthase activity			ovary(2)	2	all_cancers(5;6.38e-10)|all_epithelial(5;1.1e-10)|Melanoma(3;1.93e-05)|Breast(55;0.218)|all_neural(166;0.219)	all_lung(203;1.29e-06)|Lung NSC(69;9.35e-06)|all_epithelial(167;0.00124)		Lung(183;0.0112)|LUSC - Lung squamous cell carcinoma(189;0.0595)		GTACATGTTCCCATTGTGAGTG	0.535			NA											15	794					0	0	6.4e-05	0	0
NBPF14	25832	broad.mit.edu	37	1	148009508	148009509	+	Missense_Mutation	DNP	CC	CC	AA	rs143363070	by1000genomes	TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:148009508_148009509CC>AA	uc001eqq.2	-	16	1815_1816	c.1798_1799GG>TT	c.(1798-1800)GGG>TTG	p.G600L	LOC200030_uc001eqe.2_Intron|LOC200030_uc001eqf.2_Intron|LOC200030_uc001eqg.2_Intron|FLJ39739_uc001eqo.1_Intron|NBPF14_uc010pab.1_Intron|NBPF14_uc010pac.1_Missense_Mutation_p.G173L|NBPF14_uc001eqx.2_Intron|NBPF14_uc010pad.1_Intron|NBPF14_uc001eqs.1_Intron	NM_015383	NP_056198	Q5TI25	NBPFE_HUMAN	hypothetical protein LOC25832	600	NBPF 7.					cytoplasm				ovary(1)	1	all_hematologic(923;0.032)					CAACAGCTCCCCGCTGAGCCTG	0.465			NA											16	765					0	0	6.4e-05	0	0
BOLA1	51027	broad.mit.edu	37	1	149871704	149871704	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:149871704C>G	uc001etf.2	+	2	213	c.92C>G	c.(91-93)CCG>CGG	p.P31R		NM_016074	NP_057158	Q9Y3E2	BOLA1_HUMAN	bolA-like 1	31						extracellular region	protein binding			ovary(1)	1	Breast(34;0.0124)|all_hematologic(923;0.127)		STAD - Stomach adenocarcinoma(528;0.133)|LUSC - Lung squamous cell carcinoma(543;0.221)			GCCATCGGTCCGGTGGAGGCC	0.692			NA											3	38					0	0	0.00024832	0	0
S100A10	6281	broad.mit.edu	37	1	151955702	151955702	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:151955702C>G	uc001ezl.2	-	3	739	c.231G>C	c.(229-231)GCG>GCC	p.A77A		NM_002966	NP_002957	P60903	S10AA_HUMAN	S100 calcium binding protein A10	77					signal transduction		calcium ion binding|receptor binding				0	Melanoma(130;0.0648)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.246)			TGGTGAGGCCCGCAATTAGGG	0.458			NA											6	185					0	0	8.12818e-05	0	0
RPTN	126638	broad.mit.edu	37	1	152128155	152128156	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:152128155_152128156GG>TT	uc001ezs.1	-	3	1484_1485	c.1419_1420CC>AA	c.(1417-1422)TCCCAC>TCAAAC	p.H474N		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	474	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						TGACTGTAGTGGGAACTCTGGC	0.51			NA											30	812					0	0	6.4e-05	0	0
RPTN	126638	broad.mit.edu	37	1	152128623	152128624	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:152128623_152128624GG>TT	uc001ezs.1	-	3	1016_1017	c.951_952CC>AA	c.(949-954)TCCCAC>TCAAAC	p.H318N		NM_001122965	NP_001116437	Q6XPR3	RPTN_HUMAN	repetin	318	Gln-rich.					proteinaceous extracellular matrix	calcium ion binding				0						TGACTGTAGTGGGAACTCTGGC	0.515			NA											18	831					0	0	6.4e-05	0	0
HRNR	388697	broad.mit.edu	37	1	152187633	152187634	+	Missense_Mutation	DNP	GG	GG	TC			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:152187633_152187634GG>TC	uc001ezt.1	-	3	6547_6548	c.6471_6472CC>GA	c.(6469-6474)TCCCGC>TCGAGC	p.R2158S		NM_001009931	NP_001009931	Q86YZ3	HORN_HUMAN	hornerin	2158	24.				keratinization		calcium ion binding|protein binding			skin(2)|ovary(1)	3	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGACCATAGCGGGAAGACGAAC	0.619			NA											34	878					0	0	6.4e-05	0	0
FLG	2312	broad.mit.edu	37	1	152279996	152279997	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:152279996_152279997GG>TT	uc001ezu.1	-	3	7401_7402	c.7365_7366CC>AA	c.(7363-7368)TCCCAA>TCAAAA	p.Q2456K		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	2456	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGACCCTCTTGGGACGTTGAGT	0.584			NA							Ichthyosis				15	426					0	0	6.4e-05	0	0
FLG	2312	broad.mit.edu	37	1	152282432	152282432	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:152282432C>G	uc001ezu.1	-	3	4966	c.4930G>C	c.(4930-4932)GGG>CGG	p.G1644R		NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	1644	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			GCAGAGTGCCCATGACTGGCT	0.552			NA							Ichthyosis				8	400					0	0	0.000274275	0	0
FLG	2312	broad.mit.edu	37	1	152286385	152286385	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:152286385C>G	uc001ezu.1	-	3	1013	c.977G>C	c.(976-978)TGG>TCG	p.W326S	uc001ezv.2_RNA	NM_002016	NP_002007	P20930	FILA_HUMAN	filaggrin	326	Ser-rich.				keratinocyte differentiation	cytoplasmic membrane-bounded vesicle|intermediate filament	calcium ion binding|structural molecule activity			ovary(9)|skin(4)|upper_aerodigestive_tract(3)	16	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			TGACTGCTCCCACGCAGATCC	0.567			NA							Ichthyosis				5	261					0	0	1.23904e-05	0	0
FLG2	388698	broad.mit.edu	37	1	152323752	152323752	+	Silent	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:152323752G>C	uc001ezw.3	-	3	6583	c.6510C>G	c.(6508-6510)TCC>TCG	p.S2170S	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	2170	Filaggrin 10.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CAGTTGTCCTGGAACCTGTCT	0.512			NA											7	292					0	0	8.12818e-05	0	0
FLG2	388698	broad.mit.edu	37	1	152329769	152329769	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:152329769G>A	uc001ezw.3	-	3	566	c.493C>T	c.(493-495)CAA>TAA	p.Q165*	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	165	Ser-rich.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			AAATTACCTTGTCTTCCTAGC	0.493			NA											204	54					0	0	0.000147903	0	0
PGLYRP3	114771	broad.mit.edu	37	1	153277474	153277474	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:153277474G>C	uc001fbn.1	-	3	378	c.325C>G	c.(325-327)CAG>GAG	p.Q109E		NM_052891	NP_443123	Q96LB9	PGRP3_HUMAN	peptidoglycan recognition protein 3 precursor	109					defense response to Gram-positive bacterium|detection of bacterium|innate immune response|peptidoglycan catabolic process	extracellular region|intracellular|membrane	N-acetylmuramoyl-L-alanine amidase activity|peptidoglycan receptor activity|zinc ion binding			ovary(2)|pancreas(1)|skin(1)	4	all_lung(78;3.35e-32)|Lung NSC(65;1.22e-30)|Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.171)			TTGTAGCCCTGGGTGTGCAAG	0.498			NA											4	55					0	0	1.23904e-05	0	0
UBAP2L	9898	broad.mit.edu	37	1	154239019	154239020	+	Missense_Mutation	DNP	CG	CG	AT			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:154239019_154239020CG>AT	uc001fep.3	+	25	3112_3113	c.2945_2946CG>AT	c.(2944-2946)TCG>TAT	p.S982Y	UBAP2L_uc010pel.1_Missense_Mutation_p.S992Y|UBAP2L_uc001feq.2_Missense_Mutation_p.S178Y|UBAP2L_uc001fer.2_Missense_Mutation_p.S178Y	NM_014847	NP_055662	Q14157	UBP2L_HUMAN	ubiquitin associated protein 2-like isoform a	982					binding of sperm to zona pellucida		protein binding			ovary(1)|central_nervous_system(1)	2	all_lung(78;1.09e-30)|Lung NSC(65;1.66e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			CCAGATATCTCGGGTTCTGTGT	0.5			NA											8	363					0	0	6.4e-05	0	0
ATP8B2	57198	broad.mit.edu	37	1	154317908	154317908	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:154317908G>C	uc001fex.2	+	23	2680	c.2680G>C	c.(2680-2682)GGG>CGG	p.G894R		NM_020452	NP_065185	P98198	AT8B2_HUMAN	ATPase, class I, type 8B, member 2 isoform a	880	Cytoplasmic (Potential).				ATP biosynthetic process	plasma membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(1)|skin(1)	2	all_lung(78;2.62e-30)|Lung NSC(65;3.94e-28)|Hepatocellular(266;0.0877)		LUSC - Lung squamous cell carcinoma(543;0.185)			GCTGGTGCATGGGCGCTGGTC	0.527			NA									OREG0013835	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	6	417					0	0	0.000157383	0	0
MEX3A	92312	broad.mit.edu	37	1	156047009	156047009	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:156047009C>G	uc001fnd.3	-	2	919	c.919G>C	c.(919-921)GGG>CGG	p.G307R		NM_001093725	NP_001087194	A1L020	MEX3A_HUMAN	MEX3A protein	307						cytoplasmic mRNA processing body|nucleus	RNA binding|zinc ion binding				0	Hepatocellular(266;0.158)|all_neural(408;0.195)					TCGGGGCTCCCCGCCAGGAAG	0.657			NA											4	106					0	0	1.23904e-05	0	0
PRCC	5546	broad.mit.edu	37	1	156756632	156756632	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:156756632A>G	uc001fqa.2	+	3	1039	c.749A>G	c.(748-750)AAG>AGG	p.K250R	PRCC_uc001fqb.2_Missense_Mutation_p.K250R	NM_005973	NP_005964	Q92733	PRCC_HUMAN	papillary renal cell carcinoma	250					cell cycle|mitotic cell cycle checkpoint	nucleus	protein binding		PRCC/TFE3(25)	kidney(25)|central_nervous_system(2)	27	all_hematologic(923;0.0839)|Hepatocellular(266;0.158)					GCTGCTGCCAAGAGTGCTGCC	0.557			NA	T	TFE3	papillary renal 								17	9					0	0	0.000422831	0	0
CD1C	911	broad.mit.edu	37	1	158261152	158261152	+	Missense_Mutation	SNP	G	G	C	rs114534381	byFrequency	TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:158261152G>C	uc001fru.2	+	2	582	c.290G>C	c.(289-291)CGG>CCG	p.R97P	CD1C_uc001frv.2_5'Flank	NM_001765	NP_001756	P29017	CD1C_HUMAN	CD1C antigen precursor	97	Extracellular (Potential).				antigen processing and presentation|T cell activation involved in immune response	endosome membrane|integral to plasma membrane	endogenous lipid antigen binding|exogenous lipid antigen binding|glycolipid binding|lipopeptide binding			ovary(2)|skin(1)|pancreas(1)	4	all_hematologic(112;0.0378)					GGATTAACTCGGGAGATTCAA	0.363			NA											5	136					0	0	3.59834e-05	0	0
CRP	1401	broad.mit.edu	37	1	159683373	159683373	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:159683373C>G	uc001ftw.2	-	2	721	c.617G>C	c.(616-618)CGG>CCG	p.R206P	CRP_uc001ftx.1_Missense_Mutation_p.R73P|CRP_uc001fty.1_RNA	NM_000567	NP_000558	P02741	CRP_HUMAN	C-reactive protein, pentraxin-related precursor	206	Pentaxin.				acute-phase response|negative regulation of lipid storage|negative regulation of macrophage derived foam cell differentiation|opsonization		choline binding|Gram-positive bacterial cell surface binding|low-density lipoprotein particle binding|metal ion binding|protein binding			ovary(1)	1	all_hematologic(112;0.0429)				Atorvastatin(DB01076)|Bezafibrate(DB01393)	CTTCAGTGCCCGCCAGTTCAG	0.522			NA											4	66					0	0	0.00024832	0	0
PIGM	93183	broad.mit.edu	37	1	160000712	160000712	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:160000712G>C	uc001fuv.1	-	1	1072	c.818C>G	c.(817-819)CCG>CGG	p.P273R		NM_145167	NP_660150	Q9H3S5	PIGM_HUMAN	phosphatidylinositol glycan anchor biosynthesis,	273	Lumenal (Potential).				C-terminal protein lipidation|preassembly of GPI anchor in ER membrane	endoplasmic reticulum membrane|integral to membrane				ovary(2)|skin(1)	3	all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			GTAGAAGTACGGAGAAAAGTT	0.463			NA											5	205					0	0	1.23904e-05	0	0
PEA15	8682	broad.mit.edu	37	1	160182980	160182980	+	Missense_Mutation	SNP	C	C	G	rs11552719		TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:160182980C>G	uc001fvk.2	+	3	443	c.253C>G	c.(253-255)CGT>GGT	p.R85G	PEA15_uc001fvl.2_Missense_Mutation_p.R106G|PEA15_uc001fvm.2_Missense_Mutation_p.R63G	NM_003768	NP_003759	Q15121	PEA15_HUMAN	phosphoprotein enriched in astrocytes 15	85					anti-apoptosis|apoptosis|carbohydrate transport|negative regulation of glucose import	cytoplasm|microtubule associated complex	protein binding				0	all_cancers(52;3.11e-18)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.111)			CTACAGAACCCGTGTGCTGAA	0.517			NA											4	152					0	0	0.00024832	0	0
DCAF8	50717	broad.mit.edu	37	1	160188115	160188115	+	Missense_Mutation	SNP	C	C	G	rs142007100	byFrequency	TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:160188115C>G	uc001fvo.2	-	13	1988	c.1676G>C	c.(1675-1677)CGG>CCG	p.R559P	DCAF8_uc001fvn.2_Missense_Mutation_p.R559P|DCAF8_uc009wth.2_Missense_Mutation_p.R559P|DCAF8_uc010pjb.1_Missense_Mutation_p.R559P|DCAF8_uc010pjc.1_Missense_Mutation_p.R713P	NM_015726	NP_056541	Q5TAQ9	DCAF8_HUMAN	DDB1 and CUL4 associated factor 8	559						CUL4 RING ubiquitin ligase complex	protein binding			skin(2)	2						CTAGCTTACCCGGTGATGGCG	0.478			NA											5	270					0	0	3.59834e-05	0	0
DCAF8	50717	broad.mit.edu	37	1	160201110	160201110	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:160201110C>G	uc001fvo.2	-	7	1359	c.1047G>C	c.(1045-1047)GTG>GTC	p.V349V	DCAF8_uc001fvn.2_Silent_p.V349V|DCAF8_uc009wth.2_Silent_p.V349V|DCAF8_uc010pjb.1_Silent_p.V349V|DCAF8_uc010pjc.1_Silent_p.V503V	NM_015726	NP_056541	Q5TAQ9	DCAF8_HUMAN	DDB1 and CUL4 associated factor 8	349	WD 4.					CUL4 RING ubiquitin ligase complex	protein binding			skin(2)	2						CTCGTCCACCCACTGCAAACT	0.433			NA											5	189					0	0	3.59834e-05	0	0
C1orf192	257177	broad.mit.edu	37	1	161335431	161335431	+	Missense_Mutation	SNP	C	C	G	rs149688361	byFrequency	TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:161335431C>G	uc001gal.2	-	4	239	c.233G>C	c.(232-234)CGG>CCG	p.R78P		NM_001013625	NP_001013647	Q5VTH2	CA192_HUMAN	hypothetical protein LOC257177	78											0	all_cancers(52;4.64e-17)|all_hematologic(112;0.093)		BRCA - Breast invasive adenocarcinoma(70;0.00376)			CAGGGTCACCCGAGCAGGGGG	0.517			NA											6	242					0	0	8.12818e-05	0	0
SELP	6403	broad.mit.edu	37	1	169563945	169563945	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:169563945C>T	uc001ggi.3	-	13	2337	c.2272G>A	c.(2272-2274)GTG>ATG	p.V758M	SELP_uc001ggh.2_Missense_Mutation_p.V593M|SELP_uc009wvr.2_Missense_Mutation_p.V758M	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	758	Extracellular (Potential).|Sushi 9.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	CAGGTTGGCACGGTAGTTGAC	0.433			NA											8	105					0	0	0.000274275	0	0
SELP	6403	broad.mit.edu	37	1	169586367	169586367	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:169586367T>C	uc001ggi.3	-	3	445	c.380A>G	c.(379-381)AAC>AGC	p.N127S	SELP_uc001ggh.2_5'UTR|SELP_uc009wvr.2_Missense_Mutation_p.N127S	NM_003005	NP_002996	P16109	LYAM3_HUMAN	selectin P precursor	127	Extracellular (Potential).|C-type lectin.				platelet activation|platelet degranulation|positive regulation of platelet activation	external side of plasma membrane|extracellular space|integral to plasma membrane|membrane fraction|platelet alpha granule membrane|platelet dense granule membrane|soluble fraction	fucose binding|glycosphingolipid binding|heparin binding|lipopolysaccharide binding|oligosaccharide binding|sialic acid binding			ovary(2)|skin(2)	4	all_hematologic(923;0.208)				Clopidogrel(DB00758)|Heparin(DB01109)|Tirofiban(DB00775)	GTCCTCGTTGTTCCTTTTGTT	0.468			NA											157	68					0	0	0.000147903	0	0
PRRX1	5396	broad.mit.edu	37	1	170705230	170705230	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:170705230C>G	uc001ghf.2	+	4	688	c.641C>G	c.(640-642)CCT>CGT	p.P214R	PRRX1_uc001ghe.2_3'UTR	NM_022716	NP_073207	P54821	PRRX1_HUMAN	paired mesoderm homeobox 1 isoform pmx-1b	214						nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity			ovary(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					AACAATAGCCCTGCACAGGGC	0.493			NA											6	266					0	0	3.59834e-05	0	0
C1orf129	80133	broad.mit.edu	37	1	170940959	170940960	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:170940959_170940960CC>AA	uc001ghg.2	+	8	681_682	c.551_552CC>AA	c.(550-552)CCC>CAA	p.P184Q	C1orf129_uc009wvy.2_5'UTR|C1orf129_uc010plz.1_Missense_Mutation_p.P184Q	NM_025063	NP_079339	Q5TGP6	CA129_HUMAN	hypothetical protein LOC80133 isoform 2	184							binding			pancreas(1)	1	all_hematologic(923;0.0922)|Acute lymphoblastic leukemia(37;0.181)					CATGAAGATCCCTCGATTGTAA	0.436			NA											9	284					0	0	6.4e-05	0	0
DNM3	26052	broad.mit.edu	37	1	172011215	172011216	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:172011215_172011216CC>AA	uc001gie.2	+	8	1235_1236	c.1059_1060CC>AA	c.(1057-1062)ACCCTG>ACAATG	p.L354M	DNM3_uc001gid.3_Missense_Mutation_p.L354M|DNM3_uc009wwb.2_Missense_Mutation_p.L354M|DNM3_uc001gif.2_Missense_Mutation_p.L354M	NM_015569	NP_056384	Q9UQ16	DYN3_HUMAN	dynamin 3 isoform a	354					endocytosis|filopodium assembly|synapse assembly	dendritic spine|microtubule|perinuclear region of cytoplasm|postsynaptic density	GTP binding|GTPase activity|protein binding			breast(1)	1						AAGTAGATACCCTGGAACTCTC	0.361			NA											7	136					0	0	6.4e-05	0	0
SERPINC1	462	broad.mit.edu	37	1	173883925	173883926	+	Missense_Mutation	DNP	CG	CG	AT			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:173883925_173883926CG>AT	uc001gjt.2	-	2	292_293	c.173_174CG>AT	c.(172-174)CCG>CAT	p.P58H		NM_000488	NP_000479	P01008	ANT3_HUMAN	serpin peptidase inhibitor, clade C, member 1	58					blood coagulation|regulation of proteolysis	extracellular space|plasma membrane	heparin binding|protease binding|serine-type endopeptidase inhibitor activity			ovary(1)	1					Enoxaparin(DB01225)|Fondaparinux sodium(DB00569)|Heparin(DB01109)	CCTTCTTCTCCGGGGAGCGGTA	0.594			NA									OREG0013990	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	260					0	0	6.4e-05	0	0
TNN	63923	broad.mit.edu	37	1	175048794	175048794	+	Silent	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:175048794G>C	uc001gkl.1	+	3	848	c.735G>C	c.(733-735)ACG>ACC	p.T245T	TNN_uc010pmx.1_Silent_p.T245T	NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	245	EGF-like 3.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		TCTGTGACACGGGCGAGTGCT	0.662			NA											3	10					0	0	6.4e-05	0	0
TNN	63923	broad.mit.edu	37	1	175092647	175092647	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:175092647C>T	uc001gkl.1	+	12	2875	c.2762C>T	c.(2761-2763)TCT>TTT	p.S921F		NM_022093	NP_071376	Q9UQP3	TENN_HUMAN	tenascin N precursor	921	Fibronectin type-III 8.				cell growth|cell migration|signal transduction	extracellular space|proteinaceous extracellular matrix				large_intestine(5)|ovary(3)|central_nervous_system(1)	9		Breast(1374;0.000962)		KIRC - Kidney renal clear cell carcinoma(1967;0.00198)		CGCTACACCTCTGCTGACGGA	0.592			NA											65	22					0	0	0.000147903	0	0
ASTN1	460	broad.mit.edu	37	1	176918392	176918392	+	Silent	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:176918392C>T	uc001glc.2	-	12	2195	c.1983G>A	c.(1981-1983)GAG>GAA	p.E661E	ASTN1_uc001glb.1_Silent_p.E661E|ASTN1_uc001gld.1_Silent_p.E661E|ASTN1_uc009wwx.1_Silent_p.E661E	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	669	EGF-like 3.				cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						GGCACAGCTGCTCACAGCCGC	0.617			NA									OREG0014004	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	37	18					0	0	0.000159656	0	0
ASTN1	460	broad.mit.edu	37	1	177030282	177030282	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:177030282C>A	uc001glc.2	-	2	615	c.403G>T	c.(403-405)GAC>TAC	p.D135Y	ASTN1_uc001glb.1_Missense_Mutation_p.D135Y|ASTN1_uc001gld.1_Missense_Mutation_p.D135Y|ASTN1_uc009wwx.1_Missense_Mutation_p.D135Y	NM_004319	NP_004310	O14525	ASTN1_HUMAN	astrotactin isoform 1	135					cell migration|neuron cell-cell adhesion	integral to membrane				ovary(6)|skin(5)|central_nervous_system(2)|large_intestine(1)|lung(1)	15						TCAGTGGGGTCTTGTCCAGGA	0.542			NA											164	67					6.32397e-60	1.68967e-58	0.000147903	1	0
FAM5B	57795	broad.mit.edu	37	1	177199204	177199204	+	Silent	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:177199204C>T	uc001glf.2	+	2	504	c.192C>T	c.(190-192)CCC>CCT	p.P64P		NM_021165	NP_066988	Q9C0B6	FAM5B_HUMAN	family with sequence similarity 5, member B	64						extracellular region				skin(3)|ovary(2)|upper_aerodigestive_tract(1)	6						ACCGGGGCCCCTTCCACCGCG	0.627			NA											48	24					0	0	0.000147903	0	0
CFHR4	10877	broad.mit.edu	37	1	196884178	196884178	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:196884178G>C	uc001gto.2	+	5	778	c.709G>C	c.(709-711)GAG>CAG	p.E237Q	CFHR4_uc009wyy.2_Missense_Mutation_p.E483Q|CFHR4_uc001gtp.2_Missense_Mutation_p.E484Q	NM_006684	NP_006675	Q92496	FHR4_HUMAN	complement factor H-related 4 precursor	237	Sushi 4.					extracellular region	lipid transporter activity			ovary(1)|pancreas(1)|skin(1)	3						GTCAAGAGTCGAGTACCAATG	0.423			NA											4	225					0	0	0.00024832	0	0
KIF14	9928	broad.mit.edu	37	1	200534577	200534577	+	Silent	SNP	A	A	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:200534577A>G	uc010ppk.1	-	24	4321	c.3882T>C	c.(3880-3882)GAT>GAC	p.D1294D	KIF14_uc010ppj.1_Silent_p.D803D	NM_014875	NP_055690	Q15058	KIF14_HUMAN	kinesin family member 14	1294	Required for CIT-binding.				microtubule-based movement	cytoplasm|microtubule|nucleus|spindle	ATP binding|microtubule motor activity|protein binding			breast(3)|ovary(2)|skin(2)	7						GCTTACAGTTATCTTGACTTT	0.338			NA											61	21					0	0	0.000147903	0	0
ELF3	1999	broad.mit.edu	37	1	201981142	201981142	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:201981142A>T	uc001gxg.3	+	2	3413	c.221A>T	c.(220-222)GAC>GTC	p.D74V	ELF3_uc001gxi.3_Missense_Mutation_p.D74V|ELF3_uc001gxh.3_Missense_Mutation_p.D74V	NM_004433	NP_004424	P78545	ELF3_HUMAN	E74-like factor 3 (ets domain transcription	74	PNT.				epidermis development|epithelial cell differentiation|inflammatory response|mammary gland involution|negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription from RNA polymerase II promoter	Golgi apparatus|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|transcription coactivator activity				0						CAGGTTCTGGACTGGATCAGC	0.582			NA											99	47					0	0	0.000147903	0	0
ATP2B4	493	broad.mit.edu	37	1	203696691	203696691	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:203696691C>G	uc001gzw.2	+	20	4185	c.3301C>G	c.(3301-3303)CAG>GAG	p.Q1101E	ATP2B4_uc001gzv.2_Missense_Mutation_p.Q1101E|ATP2B4_uc009xaq.2_Missense_Mutation_p.Q1101E|ATP2B4_uc001gzx.2_Missense_Mutation_p.Q132E|ATP2B4_uc009xar.2_Missense_Mutation_p.Q96E|ATP2B4_uc010pqj.1_RNA|uc010pqk.1_5'Flank|SNORA77_uc001gzy.1_5'Flank	NM_001684	NP_001675	P23634	AT2B4_HUMAN	plasma membrane calcium ATPase 4 isoform 4b	1101	Cytoplasmic (Potential).|Calmodulin-binding subdomain A.				ATP biosynthetic process|platelet activation	integral to plasma membrane	ATP binding|calcium-transporting ATPase activity|calmodulin binding|metal ion binding|protein binding			ovary(2)|skin(1)	3	all_cancers(21;0.071)|all_epithelial(62;0.228)		BRCA - Breast invasive adenocarcinoma(75;0.109)			GAACCGTATCCAGACTCAGGT	0.572			NA											4	65					0	0	1.23904e-05	0	0
LRRN2	10446	broad.mit.edu	37	1	204587055	204587055	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:204587055G>T	uc001hbe.1	-	3	2454	c.2066C>A	c.(2065-2067)CCC>CAC	p.P689H	MDM4_uc001hbd.1_Intron|LRRN2_uc001hbf.1_Missense_Mutation_p.P689H|LRRN2_uc009xbf.1_Missense_Mutation_p.P689H|MDM4_uc001hbc.2_Intron	NM_006338	NP_006329	O75325	LRRN2_HUMAN	leucine rich repeat neuronal 2 precursor	689	Cytoplasmic (Potential).				cell adhesion	integral to membrane	receptor activity			central_nervous_system(2)	2	all_cancers(21;0.0519)|Breast(84;0.112)|Prostate(682;0.19)		KIRC - Kidney renal clear cell carcinoma(13;0.0584)|Kidney(21;0.0934)|BRCA - Breast invasive adenocarcinoma(75;0.143)			TGGATTCCAGGGCAGGACGAG	0.602			NA											106	36					1.47424e-42	3.91613e-41	0.000147903	1	0
IL24	11009	broad.mit.edu	37	1	207074963	207074963	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:207074963A>C	uc001hes.1	+	5	702	c.428A>C	c.(427-429)AAC>ACC	p.N143T	IL24_uc001het.1_5'UTR|IL24_uc001heu.1_Missense_Mutation_p.N144T|IL24_uc001hev.1_RNA|IL24_uc001hew.1_Intron|IL24_uc001hex.1_Intron	NM_006850	NP_006841	Q13007	IL24_HUMAN	interleukin 24 isoform 1 precursor	143					apoptosis	extracellular space	cytokine activity				0	Breast(84;0.201)					CTGGCCAACAACTTTGTTCTC	0.279			NA											4	50					0	0	0.00024832	0	0
SYT14	255928	broad.mit.edu	37	1	210273728	210273728	+	Silent	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:210273728G>A	uc009xcv.2	+	6	1158	c.1086G>A	c.(1084-1086)AAG>AAA	p.K362K	SYT14_uc001hhs.3_Silent_p.K407K|SYT14_uc001hht.3_Silent_p.K362K|SYT14_uc001hhu.3_Intron|SYT14_uc010psn.1_Silent_p.K407K|SYT14_uc010pso.1_Silent_p.K324K	NM_153262	NP_694994	Q8NB59	SYT14_HUMAN	synaptotagmin XIV isoform 4	362	Cytoplasmic (Potential).|C2 1.					integral to membrane				ovary(1)|skin(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.085)		TGGGGGAAAAGATTTTTTATT	0.333			NA											80	21					0	0	0.000147903	0	0
ESRRG	2104	broad.mit.edu	37	1	216824331	216824331	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:216824331C>G	uc001hkw.1	-	3	739	c.573G>C	c.(571-573)GTG>GTC	p.V191V	ESRRG_uc001hky.1_Silent_p.V168V|ESRRG_uc009xdp.1_Silent_p.V168V|ESRRG_uc001hkz.1_Intron|ESRRG_uc010puc.1_Silent_p.V168V|ESRRG_uc001hla.1_Silent_p.V168V|ESRRG_uc001hlb.1_Silent_p.V168V|ESRRG_uc010pud.1_5'UTR|ESRRG_uc001hlc.1_Silent_p.V168V|ESRRG_uc001hld.1_Silent_p.V168V|ESRRG_uc001hkx.1_Silent_p.V196V|ESRRG_uc009xdo.1_Silent_p.V168V|ESRRG_uc001hle.1_Silent_p.V168V	NM_001438	NP_001429	P62508	ERR3_HUMAN	estrogen-related receptor gamma isoform 1	191	Nuclear receptor.				positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor	nucleoplasm	AF-2 domain binding|retinoic acid receptor activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|zinc ion binding			ovary(1)|kidney(1)	2				OV - Ovarian serous cystadenocarcinoma(81;0.0358)|all cancers(67;0.0693)|GBM - Glioblastoma multiforme(131;0.0713)	Diethylstilbestrol(DB00255)	TCAGCATGCCCACTTTTAAAC	0.463			NA											5	183					0	0	8.12818e-05	0	0
CAPN9	10753	broad.mit.edu	37	1	230921726	230921727	+	Splice_Site	DNP	GG	GG	TT			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:230921726_230921727GG>TT	uc001htz.1	+	12	1595	c.1482_splice	c.e12-1	p.R494_splice	CAPN9_uc009xfg.1_Splice_Site_p.R431_splice|CAPN9_uc001hua.1_Splice_Site_p.R468_splice	NM_006615	NP_006606	O14815	CAN9_HUMAN	calpain 9 isoform 1						digestion|proteolysis	intracellular	calcium ion binding|calcium-dependent cysteine-type endopeptidase activity			ovary(1)	1	Breast(184;0.0871)|Ovarian(103;0.183)	Prostate(94;0.167)				TGCCCCTACAGGGATATGGATG	0.48			NA											13	619					0	0	6.4e-05	0	0
GNPAT	8443	broad.mit.edu	37	1	231396289	231396290	+	Missense_Mutation	DNP	CG	CG	AT			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:231396289_231396290CG>AT	uc001hup.3	+	3	504_505	c.298_299CG>AT	c.(298-300)CGA>ATA	p.R100I	GNPAT_uc009xfo.1_5'UTR|GNPAT_uc009xfp.2_Missense_Mutation_p.R39I	NM_014236	NP_055051	O15228	GNPAT_HUMAN	glyceronephosphate O-acyltransferase	100					ether lipid biosynthetic process|fatty acid metabolic process|organ morphogenesis	peroxisomal matrix|peroxisomal membrane	glycerone-phosphate O-acyltransferase activity			ovary(3)|breast(1)	4	Breast(184;0.0871)	all_cancers(173;0.2)|Prostate(94;0.183)				GGATGTCCTCCGAGAGGAAGTG	0.391			NA											11	386					0	0	6.4e-05	0	0
MTR	4548	broad.mit.edu	37	1	237024423	237024423	+	Splice_Site	SNP	A	A	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:237024423A>T	uc001hyi.3	+	20	2467	c.2044_splice	c.e20-2	p.G682_splice	MTR_uc010pxw.1_Splice_Site_p.G275_splice|MTR_uc010pxx.1_Intron|MTR_uc010pxy.1_Splice_Site_p.G536_splice	NM_000254	NP_000245	Q99707	METH_HUMAN	5-methyltetrahydrofolate-homocysteine						nervous system development|xenobiotic metabolic process	cytosol	cobalamin binding|homocysteine S-methyltransferase activity|methionine synthase activity|protein binding|zinc ion binding			ovary(1)|central_nervous_system(1)|pancreas(1)	3	Ovarian(103;0.0634)|Breast(184;0.221)	all_cancers(173;2.79e-22)|all_epithelial(177;4.84e-14)|Breast(1374;0.00123)|Prostate(94;0.0181)|Lung SC(1967;0.0262)|Acute lymphoblastic leukemia(190;0.117)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)	KIRC - Kidney renal clear cell carcinoma(1967;0.248)	Hydroxocobalamin(DB00200)|L-Methionine(DB00134)|Tetrahydrofolic acid(DB00116)	tgtcttttttAGGGCATTGAA	0.279			NA											7	24					0	0	3.86212e-05	0	0
RYR2	6262	broad.mit.edu	37	1	237791344	237791344	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:237791344G>T	uc001hyl.1	+	41	6524	c.6404G>T	c.(6403-6405)GGC>GTC	p.G2135V		NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2135	Cytoplasmic (By similarity).|4 X approximate repeats.				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GTGAGAATGGGCAAAGAAGAA	0.433			NA											43	20					1.11015e-26	2.84463e-25	0.000147903	1	0
RYR2	6262	broad.mit.edu	37	1	237843766	237843766	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:237843766C>A	uc001hyl.1	+	62	9026	c.8906C>A	c.(8905-8907)CCT>CAT	p.P2969H	RYR2_uc010pxz.1_5'UTR	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	2969	Modulator (Potential).|Cytoplasmic (By similarity).				cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			GTCGTTCTTCCTTTAATTGAT	0.423			NA											37	12					1.69901e-12	3.97592e-11	0.000191422	1	0
RYR2	6262	broad.mit.edu	37	1	237886477	237886477	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:237886477C>A	uc001hyl.1	+	74	10724	c.10604C>A	c.(10603-10605)CCA>CAA	p.P3535Q	RYR2_uc010pxz.1_Missense_Mutation_p.P490Q	NM_001035	NP_001026	Q92736	RYR2_HUMAN	cardiac muscle ryanodine receptor	3535					cardiac muscle contraction|detection of calcium ion|induction of apoptosis by ionic changes|regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion|release of sequestered calcium ion into cytosol by sarcoplasmic reticulum|response to caffeine|response to hypoxia|response to redox state	calcium channel complex|cytosol|plasma membrane|plasma membrane enriched fraction|sarcoplasmic reticulum membrane	calcium ion binding|calmodulin binding|identical protein binding|protein kinase A catalytic subunit binding|protein kinase A regulatory subunit binding|receptor activity|ryanodine-sensitive calcium-release channel activity|suramin binding			ovary(17)|large_intestine(6)|central_nervous_system(6)|pancreas(3)|breast(1)	33	Ovarian(103;0.103)	all_cancers(173;0.000368)|Melanoma(53;0.0179)|all_epithelial(177;0.0225)	OV - Ovarian serous cystadenocarcinoma(106;0.00606)			AAAGACTTACCAAACAGGACT	0.398			NA											9	272					0.000442599	0.00887779	0.000442599	1	0
WDR64	128025	broad.mit.edu	37	1	241946679	241946679	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:241946679G>C	uc001hzf.1	+	12	1483	c.1330G>C	c.(1330-1332)GTA>CTA	p.V444L	WDR64_uc001hzg.1_Missense_Mutation_p.V357L	NM_144625	NP_653226	B1ANS9	WDR64_HUMAN	WD repeat domain 64	891	WD 12.									skin(1)	1	Ovarian(103;0.103)	all_cancers(173;0.0121)	OV - Ovarian serous cystadenocarcinoma(106;0.0116)			CGATGGCTCAGTAAGGTAGGC	0.393			NA											3	32					0	0	6.4e-05	0	0
PLD5	200150	broad.mit.edu	37	1	242253166	242253167	+	Missense_Mutation	DNP	CG	CG	AT	rs147065464	byFrequency	TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:242253166_242253167CG>AT	uc001hzn.1	-	10	1727_1728	c.1600_1601CG>AT	c.(1600-1602)CGG>ATG	p.R534M	PLD5_uc001hzl.3_Missense_Mutation_p.R472M|PLD5_uc001hzm.3_Missense_Mutation_p.R324M|PLD5_uc001hzo.1_Missense_Mutation_p.R442M			Q8N7P1	PLD5_HUMAN	RecName: Full=Inactive phospholipase D5;          Short=Inactive PLD 5; AltName: Full=Inactive choline phosphatase 5; AltName: Full=Inactive phosphatidylcholine-hydrolyzing phospholipase D5; AltName: Full=PLDc;	534						integral to membrane	catalytic activity			ovary(6)	6	Melanoma(84;0.242)		OV - Ovarian serous cystadenocarcinoma(106;0.0329)			TTATACGTTCCGGGGATCCTTT	0.426			NA											11	258					0	0	6.4e-05	0	0
KIF26B	55083	broad.mit.edu	37	1	245850296	245850296	+	Silent	SNP	C	C	G	rs114792430	by1000genomes	TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:245850296C>G	uc001ibf.1	+	12	4451	c.4011C>G	c.(4009-4011)CCC>CCG	p.P1337P	KIF26B_uc001ibg.1_Silent_p.P955P|KIF26B_uc001ibh.1_Silent_p.P579P	NM_018012	NP_060482	Q2KJY2	KI26B_HUMAN	kinesin family member 26B	1337					microtubule-based movement	cytoplasm|microtubule	ATP binding|microtubule motor activity			ovary(3)	3	all_cancers(71;3.86e-05)|all_epithelial(71;0.000121)|Ovarian(71;0.0412)|all_lung(81;0.0498)|Lung NSC(105;0.0708)|Breast(184;0.127)		OV - Ovarian serous cystadenocarcinoma(106;0.022)			AGGCCAGCCCCGACAACTTGC	0.562			NA											3	20					0	0	6.4e-05	0	0
NLRP3	114548	broad.mit.edu	37	1	247588607	247588607	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:247588607T>A	uc001icr.2	+	5	2000	c.1862T>A	c.(1861-1863)CTG>CAG	p.L621Q	NLRP3_uc001ics.2_Missense_Mutation_p.L621Q|NLRP3_uc001icu.2_Missense_Mutation_p.L621Q|NLRP3_uc001icw.2_Missense_Mutation_p.L621Q|NLRP3_uc001icv.2_Missense_Mutation_p.L621Q|NLRP3_uc010pyw.1_Missense_Mutation_p.L619Q|NLRP3_uc001ict.1_Missense_Mutation_p.L619Q	NM_001079821	NP_001073289	Q96P20	NALP3_HUMAN	NLR family, pyrin domain containing 3 isoform a	621					detection of biotic stimulus|induction of apoptosis|inflammatory response|negative regulation of NF-kappaB import into nucleus|negative regulation of NF-kappaB transcription factor activity|positive regulation of interleukin-1 beta secretion|protein oligomerization|signal transduction	cytoplasm	ATP binding|peptidoglycan binding|protein binding			lung(8)|skin(8)|ovary(7)|upper_aerodigestive_tract(1)|breast(1)|pancreas(1)	26	all_cancers(71;9.66e-05)|all_epithelial(71;1.85e-05)|Breast(184;0.0226)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.0172)	OV - Ovarian serous cystadenocarcinoma(106;0.0141)			GCTAAAAAGCTGCAGATCCAG	0.473			NA											38	15					0	0	0.000191422	0	0
OR2L1P	26247	broad.mit.edu	37	1	248153852	248153852	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:248153852G>A	uc001idv.1	+	1	284	c.40G>A	c.(40-42)GGG>AGG	p.G14R	OR2L13_uc001ids.2_Intron	NR_002145				RecName: Full=Olfactory receptor 2L5; AltName: Full=Olfactory receptor OR1-53;												0						CTCCTTCACTGGGTGTGGGAT	0.423			NA											103	28					0	0	0.000147903	0	0
OR2L3	391192	broad.mit.edu	37	1	248224549	248224550	+	Missense_Mutation	DNP	TG	TG	AT			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	TG	TG	-	-	TG	TG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:248224549_248224550TG>AT	uc001idx.1	+	1	566_567	c.566_567TG>AT	c.(565-567)ATG>AAT	p.M189N	OR2L13_uc001ids.2_Intron	NM_001004687	NP_001004687	Q8NG85	OR2L3_HUMAN	olfactory receptor, family 2, subfamily L,	189	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0	all_cancers(71;0.000149)|all_epithelial(71;1.27e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0278)			CTGGCCTGCATGGACACCTGGG	0.475			NA											81	70					0	0	6.4e-05	0	0
OR2T4	127074	broad.mit.edu	37	1	248525551	248525551	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:248525551C>A	uc001ieh.1	+	1	669	c.669C>A	c.(667-669)GAC>GAA	p.D223E		NM_001004696	NP_001004696	Q8NH00	OR2T4_HUMAN	olfactory receptor, family 2, subfamily T,	223	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1	all_cancers(71;0.000108)|all_epithelial(71;1.03e-05)|Breast(184;0.00909)|Ovarian(71;0.0377)|all_lung(81;0.127)|Lung NSC(105;0.136)		OV - Ovarian serous cystadenocarcinoma(106;0.0265)			CCTGCTCAGACACCTCACTCT	0.473			NA											126	58					1.41866e-75	3.79782e-74	0.000147903	1	0
NMT2	9397	broad.mit.edu	37	10	15172176	15172176	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr10:15172176C>G	uc001inz.1	-	7	939	c.855G>C	c.(853-855)GCG>GCC	p.A285A	NMT2_uc001ioa.1_Silent_p.A272A|NMT2_uc009xjo.1_Silent_p.A285A|NMT2_uc010qbz.1_Silent_p.A97A	NM_004808	NP_004799	O60551	NMT2_HUMAN	N-myristoyltransferase 2	285					N-terminal protein myristoylation|protein lipoylation	Golgi apparatus|plasma membrane	glycylpeptide N-tetradecanoyltransferase activity			ovary(1)	1						GAACCACTCCCGCGGTGTACA	0.488	Melanoma(117;1345 1645 4130 12688 30625)		NA											4	144					0	0	1.23904e-05	0	0
PTER	9317	broad.mit.edu	37	10	16528530	16528530	+	Silent	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr10:16528530G>A	uc001iog.1	+	4	819	c.612G>A	c.(610-612)CGG>CGA	p.R204R	PTER_uc001ioh.1_Silent_p.R204R|PTER_uc001ioi.1_Silent_p.R204R|PTER_uc009xjp.1_Silent_p.R204R	NM_030664	NP_109589	Q96BW5	PTER_HUMAN	phosphotriesterase related	204					catabolic process		hydrolase activity, acting on ester bonds|zinc ion binding			ovary(2)	2						ATCCTGGACGGAGCTCCAGGG	0.507	Ovarian(2;46 150 15648 38137 47908)		NA											45	69					0	0	0.000125731	0	0
MLLT10	8028	broad.mit.edu	37	10	22021940	22021940	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr10:22021940G>T	uc001iqs.2	+	19	2727	c.2379G>T	c.(2377-2379)CAG>CAT	p.Q793H	MLLT10_uc001iqt.2_Missense_Mutation_p.Q777H|MLLT10_uc001iqv.2_RNA|MLLT10_uc001iqy.2_Missense_Mutation_p.Q777H|MLLT10_uc001ira.2_Missense_Mutation_p.Q234H|MLLT10_uc001irb.2_RNA	NM_004641	NP_004632	P55197	AF10_HUMAN	myeloid/lymphoid or mixed-lineage leukemia	793	Leucine-zipper.|Transactivation domain.				positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	DNA binding|protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(1)|skin(1)	2						TGAATGCACAGCTTTCAGTGC	0.363			NA	T	MLL|PICALM|CDK6	AL								24	57					1.12875e-08	2.55875e-07	0.000147802	1	0
YME1L1	10730	broad.mit.edu	37	10	27437844	27437844	+	Silent	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr10:27437844G>C	uc001iti.2	-	2	341	c.159C>G	c.(157-159)CCC>CCG	p.P53P	YME1L1_uc001itj.2_Silent_p.P53P|YME1L1_uc010qdl.1_Silent_p.P53P|YME1L1_uc009xkv.2_RNA|YME1L1_uc001itk.1_Silent_p.P53P	NM_139312	NP_647473	Q96TA2	YMEL1_HUMAN	YME1-like 1 isoform 1	53					protein catabolic process|proteolysis	membrane|mitochondrion	ATP binding|metal ion binding|metalloendopeptidase activity|nucleoside-triphosphatase activity			ovary(1)	1						CCTCACTGCTGGGAGCCTCAT	0.328			NA											6	259					0	0	3.59834e-05	0	0
CSGALNACT2	55454	broad.mit.edu	37	10	43678849	43678849	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr10:43678849C>G	uc001jan.2	+	8	1823	c.1488C>G	c.(1486-1488)CCC>CCG	p.P496P		NM_018590	NP_061060	Q8N6G5	CGAT2_HUMAN	chondroitin sulfate	496	Lumenal (Potential).				chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process|dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process	Golgi cisterna membrane|integral to Golgi membrane	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity|metal ion binding			ovary(1)	1						AGCTGACCCCCGAGCAGTACC	0.517			NA											4	170					0	0	3.59834e-05	0	0
AGAP6	414189	broad.mit.edu	37	10	51749117	51749117	+	Silent	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr10:51749117G>A	uc001jix.3	+	2	671	c.273G>A	c.(271-273)CAG>CAA	p.Q91Q		NM_001077665	NP_001071133	Q5VW22	AGAP6_HUMAN	ArfGAP with GTPase domain, ankyrin repeat and PH	91					regulation of ARF GTPase activity		ARF GTPase activator activity|zinc ion binding			skin(1)	1						CAATATTCCAGAGGAACTCTC	0.358			NA											8	122					0	0	3.86212e-05	0	0
BICC1	80114	broad.mit.edu	37	10	60549475	60549475	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr10:60549475G>C	uc001jki.1	+	8	829	c.829G>C	c.(829-831)GGG>CGG	p.G277R		NM_001080512	NP_001073981	Q9H694	BICC1_HUMAN	bicaudal C homolog 1	277					multicellular organismal development		RNA binding			ovary(2)|lung(1)|skin(1)	4						ACATCTTGCTGGGAGCTTAGC	0.403			NA											5	247					0	0	3.59834e-05	0	0
FAM13C	220965	broad.mit.edu	37	10	61011413	61011414	+	Missense_Mutation	DNP	CG	CG	AT	rs149458856		TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr10:61011413_61011414CG>AT	uc001jkn.2	-	14	1689_1690	c.1555_1556CG>AT	c.(1555-1557)CGA>ATA	p.R519I	FAM13C_uc001jko.2_Missense_Mutation_p.R421I|FAM13C_uc010qid.1_Missense_Mutation_p.R435I|FAM13C_uc010qie.1_Missense_Mutation_p.R436I|FAM13C_uc010qif.1_Missense_Mutation_p.R541I	NM_198215	NP_937858	Q8NE31	FA13C_HUMAN	hypothetical protein LOC220965 isoform 1	519										ovary(2)	2						CCTAGTTTCTCGGAGATGGTCA	0.401			NA											6	247					0	0	6.4e-05	0	0
ANK3	288	broad.mit.edu	37	10	61941095	61941095	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr10:61941095G>C	uc001jky.2	-	18	2368	c.2176C>G	c.(2176-2178)CAG>GAG	p.Q726E	ANK3_uc010qih.1_Missense_Mutation_p.Q709E|ANK3_uc001jkz.3_Missense_Mutation_p.Q720E|ANK3_uc001jlb.1_Missense_Mutation_p.Q255E|ANK3_uc001jlc.1_Missense_Mutation_p.Q387E	NM_020987	NP_066267	Q12955	ANK3_HUMAN	ankyrin 3 isoform 1	726					establishment of protein localization|signal transduction	basolateral plasma membrane|cytoplasm|cytoskeleton	protein binding			skin(9)|ovary(6)|pancreas(2)|central_nervous_system(2)	19						ACCTTTGTCTGGGCGTCCACA	0.498			NA											6	214					0	0	3.59834e-05	0	0
GRID1	2894	broad.mit.edu	37	10	87614258	87614258	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr10:87614258G>T	uc001kdl.1	-	8	1329	c.1228C>A	c.(1228-1230)CGC>AGC	p.R410S	GRID1_uc009xsu.1_RNA	NM_017551	NP_060021	Q9ULK0	GRID1_HUMAN	glutamate receptor, ionotropic, delta 1	410	Extracellular (Potential).					cell junction|integral to membrane|outer membrane-bounded periplasmic space|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|ionotropic glutamate receptor activity			ovary(5)|upper_aerodigestive_tract(2)|large_intestine(2)|central_nervous_system(1)	10					L-Glutamic Acid(DB00142)	CTTACCTTGCGCATGTCTTTG	0.512			NA								Multiple Myeloma(13;0.14)			25	42					1.32181e-22	3.31295e-21	0.000184323	1	0
GLUD1	2746	broad.mit.edu	37	10	88827869	88827869	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr10:88827869C>G	uc001keh.2	-	5	789	c.692G>C	c.(691-693)CGG>CCG	p.R231P	GLUD1_uc001keg.2_Missense_Mutation_p.R64P|GLUD1_uc010qmp.1_Missense_Mutation_p.R98P	NM_005271	NP_005262	P00367	DHE3_HUMAN	glutamate dehydrogenase 1 precursor	231					glutamate biosynthetic process|glutamate catabolic process|positive regulation of insulin secretion	mitochondrial matrix	ADP binding|ATP binding|glutamate dehydrogenase|glutamate dehydrogenase activity|GTP binding|identical protein binding|leucine binding|NAD+ binding				0					L-Glutamic Acid(DB00142)|NADH(DB00157)	GGACATCTCCCGCTCACCTGT	0.532			NA											4	48					0	0	3.59834e-05	0	0
MYOF	26509	broad.mit.edu	37	10	95211878	95211879	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr10:95211878_95211879CC>AA	uc001kin.2	-	3	287_288	c.164_165GG>TT	c.(163-165)AGG>ATT	p.R55I	MYOF_uc001kio.2_Missense_Mutation_p.R55I|MYOF_uc001kip.3_Missense_Mutation_p.R55I|MYOF_uc009xuf.2_Missense_Mutation_p.R37I	NM_013451	NP_038479	Q9NZM1	MYOF_HUMAN	myoferlin isoform a	55	C2 1.|Cytoplasmic (Potential).				blood circulation|muscle contraction|plasma membrane repair	caveola|cytoplasmic vesicle membrane|integral to membrane|nuclear membrane	phospholipid binding|protein binding			ovary(3)|breast(1)	4						GTGGTATACCCCTCAAGTCAAA	0.356			NA											9	276					0	0	6.4e-05	0	0
EXOSC1	51013	broad.mit.edu	37	10	99203015	99203015	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr10:99203015C>G	uc001kni.2	-	3	227	c.201G>C	c.(199-201)GTG>GTC	p.V67V	EXOSC1_uc009xvp.1_Intron|ZDHHC16_uc001knp.2_5'Flank|ZDHHC16_uc001knk.2_5'Flank|ZDHHC16_uc001knl.2_5'Flank|ZDHHC16_uc001knm.2_5'Flank|ZDHHC16_uc001knn.2_5'Flank|ZDHHC16_uc010qow.1_5'Flank|ZDHHC16_uc009xvq.2_5'Flank|ZDHHC16_uc001kno.2_5'Flank|ZDHHC16_uc001knj.2_5'Flank	NM_016046	NP_057130	Q9Y3B2	EXOS1_HUMAN	exosomal core protein CSL4	67	S1 motif.				exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA processing	cytosol|exosome (RNase complex)|nucleolus	protein binding|RNA binding				0		Renal(717;0.000147)|Colorectal(252;0.00205)|Ovarian(717;0.00965)		all cancers(201;8.29e-42)|Epithelial(162;5.7e-33)|BRCA - Breast invasive adenocarcinoma(275;0.000315)|Kidney(138;0.000832)|KIRC - Kidney renal clear cell carcinoma(50;0.00269)|STAD - Stomach adenocarcinoma(243;0.202)		CAATAGCTCCCACATCTGGCA	0.418			NA											6	266					0	0	8.12818e-05	0	0
DHDPSL	112817	broad.mit.edu	37	10	99371273	99371273	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr10:99371273C>G	uc001kny.2	+	7	1200	c.841C>G	c.(841-843)CGG>GGG	p.R281G	DHDPSL_uc001knz.2_Missense_Mutation_p.R118G|PI4K2A_uc010qoy.1_Intron	NM_138413	NP_612422	Q86XE5	HOGA1_HUMAN	DHDPS-like protein isoform 1	281					glyoxylate catabolic process	mitochondrion	4-hydroxy-2-oxoglutarate aldolase activity				0						GCAGGTGACCCGGCGCTTTGG	0.552			NA											4	106					0	0	3.59834e-05	0	0
PSD	5662	broad.mit.edu	37	10	104171930	104171930	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr10:104171930C>G	uc001kvg.1	-	7	2330	c.1803G>C	c.(1801-1803)ACG>ACC	p.T601T	PSD_uc001kvf.1_5'Flank|PSD_uc001kvh.1_Silent_p.T222T|PSD_uc009xxd.1_Silent_p.T601T	NM_002779	NP_002770	A5PKW4	PSD1_HUMAN	pleckstrin and Sec7 domain containing	601	SEC7.				regulation of ARF protein signal transduction	cytoplasm|plasma membrane|ruffle	ARF guanyl-nucleotide exchange factor activity|signal transducer activity			breast(2)|urinary_tract(1)	3				Epithelial(162;1.27e-08)|all cancers(201;2.85e-07)		GAGTCATGCCCGTGAAGACAA	0.582			NA											5	156					0	0	8.12818e-05	0	0
GFRA1	2674	broad.mit.edu	37	10	117849334	117849334	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr10:117849334C>G	uc001lcj.2	-	9	1813	c.1115G>C	c.(1114-1116)CGG>CCG	p.R372P	GFRA1_uc001lci.2_Missense_Mutation_p.R367P|GFRA1_uc009xyr.2_Missense_Mutation_p.R367P	NM_005264	NP_005255	P56159	GFRA1_HUMAN	GDNF family receptor alpha 1 isoform a	372					axon guidance	anchored to membrane|extrinsic to membrane|plasma membrane	glial cell-derived neurotrophic factor receptor activity			ovary(1)|pancreas(1)	2		Lung NSC(174;0.21)		all cancers(201;0.0337)		GTTCTTAACCCGGAGGGCAGT	0.542	Ovarian(128;329 1725 45498 46808 50759)		NA											3	59					0	0	0.00024832	0	0
KCNK18	338567	broad.mit.edu	37	10	118957090	118957090	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr10:118957090G>C	uc010qsr.1	+	1	91	c.91G>C	c.(91-93)GTG>CTG	p.V31L		NM_181840	NP_862823	Q7Z418	KCNKI_HUMAN	potassium channel, subfamily K, member 18	31	Helical; (Potential).					integral to membrane|plasma membrane				upper_aerodigestive_tract(1)	1		Colorectal(252;0.19)		all cancers(201;0.0211)		CTGCTTTCTGGTGACCTACGC	0.607			NA											18	27					0	0	9.7654e-05	0	0
RAB11FIP2	22841	broad.mit.edu	37	10	119798562	119798562	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr10:119798562G>C	uc001ldj.1	-	3	1626	c.1186C>G	c.(1186-1188)CGC>GGC	p.R396G	RAB11FIP2_uc009xyz.1_Missense_Mutation_p.R396G	NM_014904	NP_055719	Q7L804	RFIP2_HUMAN	RAB11 family interacting protein 2	396					protein transport	plasma membrane|recycling endosome membrane	protein homodimerization activity				0		Colorectal(252;0.235)		all cancers(201;0.0238)		TAGTCCTGGCGATTTTCACTA	0.373			NA											51	88					0	0	0.000147903	0	0
C10orf119	79892	broad.mit.edu	37	10	121600410	121600410	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr10:121600410C>G	uc001ler.2	-	11	1491	c.1193G>C	c.(1192-1194)CGG>CCG	p.R398P	C10orf119_uc001leq.1_Missense_Mutation_p.R223P|C10orf119_uc001les.1_Missense_Mutation_p.R223P	NM_024834	NP_079110	Q9BTE3	MCMBP_HUMAN	chromosome 10 open reading frame 119	398					cell division|DNA-dependent DNA replication|mitosis|S phase of mitotic cell cycle|sister chromatid cohesion	nucleus	chromatin binding				0		Lung NSC(174;0.109)|all_lung(145;0.142)		all cancers(201;0.0044)		GGTACTATTCCGTGGGCAACC	0.328			NA											4	118					0	0	1.23904e-05	0	0
FGFR2	2263	broad.mit.edu	37	10	123256051	123256052	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr10:123256051_123256052GG>TT	uc010qtk.1	-	14	2504_2505	c.1857_1858CC>AA	c.(1855-1860)TCCCAA>TCAAAA	p.Q620K	FGFR2_uc010qtg.1_Missense_Mutation_p.Q508K|FGFR2_uc010qth.1_Missense_Mutation_p.Q505K|FGFR2_uc010qti.1_Missense_Mutation_p.Q531K|FGFR2_uc010qtj.1_Missense_Mutation_p.Q621K|FGFR2_uc010qtl.1_Missense_Mutation_p.Q504K|FGFR2_uc010qtm.1_Missense_Mutation_p.Q503K|FGFR2_uc001lfl.3_Missense_Mutation_p.Q621K|FGFR2_uc001lfm.2_Missense_Mutation_p.Q532K|FGFR2_uc001lfg.3_Missense_Mutation_p.Q228K	NM_000141	NP_000132	P21802	FGFR2_HUMAN	fibroblast growth factor receptor 2 isoform 1	620	Cytoplasmic (Potential).|Protein kinase.				angiogenesis|axonogenesis|bone mineralization|bone morphogenesis|branch elongation involved in salivary gland morphogenesis|branching involved in embryonic placenta morphogenesis|branching morphogenesis of a nerve|bud elongation involved in lung branching|cell fate commitment|cell growth|cell-cell signaling|cellular response to protein stimulus|embryonic digestive tract morphogenesis|embryonic pattern specification|epithelial cell proliferation involved in salivary gland morphogenesis|fibroblast growth factor receptor signaling pathway involved in hemopoiesis|fibroblast growth factor receptor signaling pathway involved in mammary gland specification|fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptosis in bone marrow|fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development|fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow|hair follicle morphogenesis|insulin receptor signaling pathway|lacrimal gland development|lateral sprouting from an epithelium|limb bud formation|lung alveolus development|lung lobe morphogenesis|lung-associated mesenchyme development|mammary gland bud formation|membranous septum morphogenesis|mesenchymal cell differentiation involved in lung development|mesenchymal cell proliferation involved in lung development|midbrain development|multicellular organism growth|negative regulation of transcription from RNA polymerase II promoter|odontogenesis|organ growth|otic vesicle formation|outflow tract septum morphogenesis|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of cardiac muscle cell proliferation|positive regulation of cell cycle|positive regulation of cell division|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of ERK1 and ERK2 cascade|positive regulation of mesenchymal cell proliferation|positive regulation of transcription from RNA polymerase II promoter|post-embryonic development|prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis|prostate epithelial cord elongation|pyramidal neuron development|regulation of branching involved in prostate gland morphogenesis|regulation of cell fate commitment|regulation of fibroblast growth factor receptor signaling pathway|regulation of multicellular organism growth|regulation of smooth muscle cell differentiation|regulation of smoothened signaling pathway|squamous basal epithelial stem cell differentiation involved in prostate gland acinus development|ureteric bud development|ventricular cardiac muscle tissue morphogenesis|ventricular zone neuroblast division	cell cortex|cell surface|excitatory synapse|extracellular region|integral to membrane|nucleus|plasma membrane	ATP binding|fibroblast growth factor binding|fibroblast growth factor binding|fibroblast growth factor receptor activity|heparin binding|protein binding			endometrium(44)|skin(28)|lung(11)|ovary(4)|cervix(2)|stomach(2)|breast(2)|upper_aerodigestive_tract(1)|soft_tissue(1)|central_nervous_system(1)	96		Lung NSC(174;0.0841)|all_lung(145;0.106)|all_neural(114;0.107)	STAD - Stomach adenocarcinoma(1;7.52e-05)|all cancers(1;0.0722)	all cancers(201;9.73e-05)|GBM - Glioblastoma multiforme(135;0.0845)	Palifermin(DB00039)	CTCACTTTTTGGGAAGCCAAGT	0.446			5	Mis		gastric. NSCLC|endometrial		Crouzon|Pfeiffer|and Apert syndromes		Apert_syndrome|Saethre-Chotzen_syndrome				12	509					0	0	6.4e-05	0	0
DMBT1	1755	broad.mit.edu	37	10	124339299	124339299	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr10:124339299C>G	uc001lgk.1	+	10	991	c.885C>G	c.(883-885)CCC>CCG	p.P295P	DMBT1_uc001lgl.1_Silent_p.P295P|DMBT1_uc001lgm.1_Silent_p.P295P|DMBT1_uc009xzz.1_Silent_p.P295P|DMBT1_uc010qtx.1_Intron|DMBT1_uc009yaa.1_Silent_p.P147P	NM_007329	NP_015568	Q9UGM3	DMBT1_HUMAN	deleted in malignant brain tumors 1 isoform b	295	SRCR 2.				epithelial cell differentiation|induction of bacterial agglutination|innate immune response|interspecies interaction between organisms|protein transport|response to virus	extrinsic to membrane|phagocytic vesicle membrane|zymogen granule membrane	calcium-dependent protein binding|Gram-negative bacterial cell surface binding|Gram-positive bacterial cell surface binding|pattern recognition receptor activity|scavenger receptor activity|zymogen binding			central_nervous_system(7)	7		all_neural(114;0.0765)|Lung NSC(174;0.132)|all_lung(145;0.163)|Breast(234;0.238)				GCTCAGGACCCATTGTCCTGG	0.597	Ovarian(182;93 2026 18125 22222 38972)		NA											5	149					0	0	3.59834e-05	0	0
FAM175B	23172	broad.mit.edu	37	10	126517402	126517402	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr10:126517402C>T	uc001lib.3	+	6	581	c.536C>T	c.(535-537)CCA>CTA	p.P179L		NM_032182	NP_115558	Q15018	F175B_HUMAN	hypothetical protein LOC23172	179						BRISC complex	polyubiquitin binding				0						TCTTCAGTGCCAAATACTTCT	0.353			NA											30	62					0	0	8.91981e-05	0	0
MKI67	4288	broad.mit.edu	37	10	129906815	129906815	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr10:129906815G>C	uc001lke.2	-	13	3484	c.3289C>G	c.(3289-3291)CAG>GAG	p.Q1097E	MKI67_uc001lkf.2_Missense_Mutation_p.Q737E|MKI67_uc009yav.1_Missense_Mutation_p.Q672E|MKI67_uc009yaw.1_Missense_Mutation_p.Q247E	NM_002417	NP_002408	P46013	KI67_HUMAN	antigen identified by monoclonal antibody Ki-67	1097	16 X 122 AA approximate repeats.|1.				cell proliferation	nucleolus	ATP binding|protein C-terminus binding			ovary(4)|central_nervous_system(2)|skin(1)	7		all_epithelial(44;2.12e-05)|all_lung(145;0.00679)|Lung NSC(174;0.00998)|all_neural(114;0.0936)|Colorectal(57;0.14)|Breast(234;0.166)|Melanoma(40;0.203)				TCTAGTGACTGGGCCTCTTCC	0.502			NA											6	244					0	0	8.12818e-05	0	0
RIC8A	60626	broad.mit.edu	37	11	209514	209514	+	Silent	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:209514G>C	uc001log.2	+	3	565	c.240G>C	c.(238-240)CTG>CTC	p.L80L	BET1L_uc001loe.2_5'Flank|BET1L_uc001lod.2_5'Flank|RIC8A_uc001lof.2_Silent_p.L80L|RIC8A_uc001loh.2_Silent_p.L73L	NM_021932	NP_068751	Q9NPQ8	RIC8A_HUMAN	resistance to inhibitors of cholinesterase 8	80						cytoplasm|plasma membrane	guanyl-nucleotide exchange factor activity				0		all_cancers(49;9.23e-07)|all_epithelial(84;0.000315)|Breast(177;0.00122)|Ovarian(85;0.0202)|Medulloblastoma(188;0.0321)|all_neural(188;0.0762)		all cancers(45;4.45e-27)|Epithelial(43;2.94e-26)|OV - Ovarian serous cystadenocarcinoma(40;5.86e-21)|BRCA - Breast invasive adenocarcinoma(625;3.57e-05)|Lung(200;0.105)|LUSC - Lung squamous cell carcinoma(625;0.122)		GCAACTGCCTGGACCCGTTCA	0.632			NA											4	53					0	0	1.23904e-05	0	0
MUC6	4588	broad.mit.edu	37	11	1017488	1017488	+	Silent	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:1017488G>T	uc001lsw.2	-	31	5364	c.5313C>A	c.(5311-5313)CCC>CCA	p.P1771P		NM_005961	NP_005952	Q6W4X9	MUC6_HUMAN	mucin 6, gastric	1771	Thr-rich.|Approximate repeats.				maintenance of gastrointestinal epithelium	extracellular region	extracellular matrix structural constituent			ovary(1)	1		all_cancers(49;3.3e-08)|all_epithelial(84;5.08e-05)|Breast(177;0.000307)|Ovarian(85;0.000953)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		all cancers(45;1.24e-24)|BRCA - Breast invasive adenocarcinoma(625;0.00031)|Lung(200;0.0576)|LUSC - Lung squamous cell carcinoma(625;0.0703)		TGGTGTGGTTGGGGGTGATGC	0.572			NA											15	638					9.7654e-05	0.00205148	9.7654e-05	1	0
CTSD	1509	broad.mit.edu	37	11	1778748	1778748	+	Silent	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:1778748G>A	uc001luc.1	-	5	643	c.510C>T	c.(508-510)GGC>GGT	p.G170G	CTSD_uc009yda.1_RNA	NM_001909	NP_001900	P07339	CATD_HUMAN	cathepsin D preproprotein	170					cell death|proteolysis	extracellular space|lysosome|melanosome	aspartic-type endopeptidase activity				0		all_epithelial(84;0.00018)|Ovarian(85;0.0014)|Breast(177;0.00147)|Medulloblastoma(188;0.0109)|all_neural(188;0.0299)|Lung NSC(207;0.229)		BRCA - Breast invasive adenocarcinoma(625;0.00136)|Lung(200;0.0684)|LUSC - Lung squamous cell carcinoma(625;0.0822)	Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CTTTGACACCGCCCAGGGCAG	0.642			NA									OREG0003774	type=REGULATORY REGION|Gene=CTSD|Dataset=Stanford ENCODE Dataset|EvidenceSubtype=Transient transfection luciferase assay	7	10					0	0	8.12818e-05	0	0
OR51E2	81285	broad.mit.edu	37	11	4702997	4702997	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:4702997C>A	uc001lzk.2	-	2	1189	c.945G>T	c.(943-945)CAG>CAT	p.Q315H		NM_030774	NP_110401	Q9H255	O51E2_HUMAN	olfactory receptor, family 51, subfamily E,	315	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			lung(3)|ovary(2)	5		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;3e-12)|BRCA - Breast invasive adenocarcinoma(625;0.00476)|LUSC - Lung squamous cell carcinoma(625;0.2)		CTCCCACAGCCTGCAAGTCCT	0.438			NA											27	39					5.45727e-16	1.3128e-14	0.000227799	1	0
OR52E6	390078	broad.mit.edu	37	11	5862711	5862711	+	Silent	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:5862711G>C	uc010qzq.1	-	1	417	c.417C>G	c.(415-417)ACC>ACG	p.T139T	TRIM5_uc001mbq.1_Intron	NM_001005167	NP_001005167	Q96RD3	O52E6_HUMAN	olfactory receptor, family 52, subfamily E,	139	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(1)	1		Medulloblastoma(188;0.0075)|all_neural(188;0.0577)|Breast(177;0.086)		Epithelial(150;2.55e-09)|BRCA - Breast invasive adenocarcinoma(625;0.135)		TGATTTTGCTGGTGAGGATCA	0.488			NA											5	231					0	0	1.23904e-05	0	0
OR5P3	120066	broad.mit.edu	37	11	7847399	7847399	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:7847399C>A	uc010rbg.1	-	1	121	c.121G>T	c.(121-123)GGT>TGT	p.G41C		NM_153445	NP_703146	Q8WZ94	OR5P3_HUMAN	olfactory receptor, family 5, subfamily P,	41	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			skin(1)	1				Epithelial(150;8.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.189)		CTGATATTACCCATTAAGGTG	0.368			NA											29	63					1.13719e-10	2.61668e-09	0.000227799	1	0
KCNC1	3746	broad.mit.edu	37	11	17793440	17793440	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:17793440T>G	uc001mnk.3	+	2	854	c.799T>G	c.(799-801)TGC>GGC	p.C267G	KCNC1_uc009yhc.1_Missense_Mutation_p.C267G	NM_004976	NP_004967	P48547	KCNC1_HUMAN	Shaw-related voltage-gated potassium channel	267	Helical; Name=Segment S2; (Potential).					voltage-gated potassium channel complex	voltage-gated potassium channel activity			upper_aerodigestive_tract(1)	1						TGTCATCTTCTGCCCCAACAA	0.572			NA											62	103					0	0	0.000147903	0	0
TPH1	7166	broad.mit.edu	37	11	18050857	18050858	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:18050857_18050858CC>AA	uc001mnp.2	-	5	547_548	c.521_522GG>TT	c.(520-522)TGG>TTT	p.W174F	TPH1_uc009yhe.2_Intron	NM_004179	NP_004170	P17752	TPH1_HUMAN	tryptophan hydroxylase 1	174					aromatic amino acid family metabolic process|hormone biosynthetic process|serotonin biosynthetic process	cytosol	amino acid binding|iron ion binding|tryptophan 5-monooxygenase activity				0					L-Tryptophan(DB00150)|Tetrahydrobiopterin(DB00360)	ATACGGTTCCCCAGGTCTTAAT	0.396			NA											14	426					0	0	6.4e-05	0	0
Unknown	0	broad.mit.edu	37	11	31086079	31086079	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:31086079C>G	uc009yjk.1	-	8	941	c.872G>C	c.(871-873)GGG>GCG	p.G291A	uc009yjl.1_Missense_Mutation_p.G219A|DCDC1_uc001msu.1_Missense_Mutation_p.G462A					RecName: Full=Doublecortin domain-containing protein 5;												NA						TGTCAGCTCCCCCGTCTCCTC	0.488			NA											5	204					0	0	1.23904e-05	0	0
SLC1A2	6506	broad.mit.edu	37	11	35313850	35313850	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:35313850G>C	uc001mwd.2	-	7	1667	c.1075C>G	c.(1075-1077)CTG>GTG	p.L359V	SLC1A2_uc001mwe.2_Missense_Mutation_p.L350V|SLC1A2_uc010rev.1_Missense_Mutation_p.L359V	NM_004171	NP_004162	P43004	EAA2_HUMAN	excitatory amino acid transporter 2	359					D-aspartate import|L-glutamate import|synaptic transmission	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity			ovary(2)|central_nervous_system(1)	3	all_lung(20;0.211)|all_epithelial(35;0.234)	all_hematologic(20;0.109)	STAD - Stomach adenocarcinoma(6;0.00731)		L-Glutamic Acid(DB00142)	GCGGTGCCCAGGGCAGTGATC	0.468	NSCLC(100;1273 1575 12993 16869 47409)|Ovarian(164;45 1946 8965 30452 48454)		NA											6	307					0	0	8.12818e-05	0	0
RAG1	5896	broad.mit.edu	37	11	36597288	36597288	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:36597288C>G	uc001mwu.3	+	2	2558	c.2434C>G	c.(2434-2436)CAG>GAG	p.Q812E	RAG1_uc001mwt.2_RNA	NM_000448	NP_000439	P15918	RAG1_HUMAN	recombination activating gene 1	812					histone monoubiquitination|immune response|pre-B cell allelic exclusion|protein autoubiquitination|T cell differentiation in thymus|V(D)J recombination	nucleus	endonuclease activity|histone binding|protein homodimerization activity|sequence-specific DNA binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|pancreas(1)|lung(1)|kidney(1)|skin(1)	5	all_lung(20;0.226)	all_hematologic(20;0.107)				CAAGATCTTCCAGCTAGAGAT	0.473	Pancreas(43;321 1249 3212 48200)|Esophageal Squamous(38;49 1003 17530 24363)		NA							Familial_Hemophagocytic_Lymphohistiocytosis				4	97					0	0	1.23904e-05	0	0
CHRM4	1132	broad.mit.edu	37	11	46407116	46407116	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:46407116C>G	uc001nct.1	-	1	992	c.992G>C	c.(991-993)CGG>CCG	p.R331P		NM_000741	NP_000732	P08173	ACM4_HUMAN	cholinergic receptor, muscarinic 4	331	Cytoplasmic (By similarity).				cell proliferation	cell junction|integral to plasma membrane|postsynaptic membrane	muscarinic acetylcholine receptor activity				0				GBM - Glioblastoma multiforme(35;0.0254)|Lung(87;0.14)	Atropine(DB00572)|Benzquinamide(DB00767)|Cryptenamine(DB00785)|Homatropine Methylbromide(DB00725)|Methotrimeprazine(DB01403)|Metixene(DB00340)|Olanzapine(DB00334)|Procyclidine(DB00387)|Promazine(DB00420)|Promethazine(DB01069)|Propiomazine(DB00777)|Thiethylperazine(DB00372)|Tropicamide(DB00809)	GTTGAGGGCCCGCGGCTGCAG	0.637	Esophageal Squamous(171;1020 1936 4566 30205 42542)		NA											6	317					0	0	0.000274275	0	0
KIAA0652	9776	broad.mit.edu	37	11	46686437	46686437	+	Silent	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:46686437G>C	uc009yld.2	+	12	1512	c.828G>C	c.(826-828)CTG>CTC	p.L276L	KIAA0652_uc001nda.2_Silent_p.L309L|KIAA0652_uc001ndb.2_Silent_p.L276L|KIAA0652_uc001ncz.2_Intron|KIAA0652_uc001ndc.2_Intron|KIAA0652_uc010rgv.1_Intron	NM_001142673	NP_001136145	O75143	ATG13_HUMAN	autophagy-related protein 13 isoform 1	276					autophagic vacuole assembly	cytosol|pre-autophagosomal structure|ULK1-ATG13-FIP200 complex	protein binding				0				GBM - Glioblastoma multiforme(35;0.226)		CTGCTGCCCTGGGCGTTGGAT	0.408			NA											6	241					0	0	0.000157383	0	0
CKAP5	9793	broad.mit.edu	37	11	46775022	46775022	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:46775022C>G	uc001ndi.1	-	37	5005	c.4895G>C	c.(4894-4896)CGG>CCG	p.R1632P	CKAP5_uc009ylg.1_Missense_Mutation_p.R1518P|CKAP5_uc001ndj.1_Missense_Mutation_p.R1572P|CKAP5_uc001ndh.1_Missense_Mutation_p.R561P	NM_001008938	NP_001008938	Q14008	CKAP5_HUMAN	colonic and hepatic tumor over-expressed protein	1632					cell division|centrosome organization|establishment or maintenance of microtubule cytoskeleton polarity|G2/M transition of mitotic cell cycle|mitotic prometaphase|RNA transport|spindle organization	centrosome|cytosol	protein binding|protein binding			ovary(1)|skin(1)	2						GGAGGCCTCCCGGGCAAGGCT	0.458	Ovarian(4;85 273 2202 4844 13323)		NA											5	122					0	0	1.23904e-05	0	0
OR5D16	390144	broad.mit.edu	37	11	55606864	55606864	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:55606864C>A	uc010rio.1	+	1	637	c.637C>A	c.(637-639)CTA>ATA	p.L213I		NM_001005496	NP_001005496	Q8NGK9	OR5DG_HUMAN	olfactory receptor, family 5, subfamily D,	213	Helical; Name=5; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(4)|skin(1)	5		all_epithelial(135;0.208)				GATAAGCACACTACTCATCAT	0.458			NA											42	58					5.2432e-18	1.27919e-16	0.000147903	1	0
OR5I1	10798	broad.mit.edu	37	11	55703186	55703186	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:55703186G>C	uc010ris.1	-	1	691	c.691C>G	c.(691-693)CGC>GGC	p.R231G		NM_006637	NP_006628	Q13606	OR5I1_HUMAN	olfactory receptor, family 5, subfamily I,	231	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CTGAAAGAGCGGATCTTTAAG	0.453			NA											3	19					0	0	6.4e-05	0	0
OR5F1	338674	broad.mit.edu	37	11	55761692	55761692	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:55761692G>A	uc010riv.1	-	1	410	c.410C>T	c.(409-411)TCC>TTC	p.S137F		NM_003697	NP_003688	O95221	OR5F1_HUMAN	olfactory receptor, family 5, subfamily F,	137	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|pancreas(1)	2	Esophageal squamous(21;0.00448)					GACGGTCCTGGACATGATCAA	0.512			NA											33	34					0	0	0.000339439	0	0
OR8H2	390151	broad.mit.edu	37	11	55872561	55872561	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:55872561C>A	uc010riy.1	+	1	43	c.43C>A	c.(43-45)CTT>ATT	p.L15I		NM_001005200	NP_001005200	Q8N162	OR8H2_HUMAN	olfactory receptor, family 8, subfamily H,	15	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	Esophageal squamous(21;0.00693)					TGACTTCATCCTTATGGGACT	0.403			NA								HNSCC(53;0.14)			76	117					9.37156e-40	2.47036e-38	0.000147903	1	0
OR5J2	282775	broad.mit.edu	37	11	55944491	55944491	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:55944491C>A	uc010rjb.1	+	1	398	c.398C>A	c.(397-399)ACT>AAT	p.T133N		NM_001005492	NP_001005492	Q8NH18	OR5J2_HUMAN	olfactory receptor, family 5, subfamily J,	133	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|large_intestine(1)|breast(1)|pancreas(1)	4	Esophageal squamous(21;0.00693)					TTGCTTTACACTGTAGCCATG	0.458			NA											42	63					6.57855e-14	1.54472e-12	0.000437636	1	0
DTX4	23220	broad.mit.edu	37	11	58949675	58949675	+	Silent	SNP	A	A	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:58949675A>C	uc001nns.2	+	2	932	c.675A>C	c.(673-675)GGA>GGC	p.G225G	DTX4_uc001nnr.2_Silent_p.G119G	NM_015177	NP_055992	Q9Y2E6	DTX4_HUMAN	deltex 4 homolog	225					Notch signaling pathway	cytoplasm	zinc ion binding			lung(2)|central_nervous_system(1)	3		all_epithelial(135;0.125)				CGCCTCCTGGAGTGGTCAAGC	0.627			NA											13	24					0	0	0.00010058	0	0
NUDT22	84304	broad.mit.edu	37	11	63994191	63994191	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:63994191G>C	uc001nyp.3	+	2	247	c.67G>C	c.(67-69)GCC>CCC	p.A23P	TRPT1_uc010rnc.1_5'Flank|TRPT1_uc010rnd.1_5'Flank|TRPT1_uc001nyn.2_5'Flank|TRPT1_uc001nyo.2_5'Flank|TRPT1_uc010rne.1_5'Flank|TRPT1_uc010rnf.1_5'Flank|NUDT22_uc009ypd.2_Missense_Mutation_p.A23P|NUDT22_uc009ype.2_Missense_Mutation_p.A23P|NUDT22_uc001nyq.3_Missense_Mutation_p.A23P|NUDT22_uc010rng.1_5'Flank	NM_032344	NP_115720	Q9BRQ3	NUD22_HUMAN	nudix (nucleoside diphosphate linked moiety	23							hydrolase activity				0						GCAGATACAGGCCGAGCTGAG	0.672			NA											3	40					0	0	6.4e-05	0	0
KCNK7	10089	broad.mit.edu	37	11	65360547	65360547	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:65360547C>G	uc001oes.2	-	3	1077	c.853G>C	c.(853-855)GGG>CGG	p.G285R	KCNK7_uc001oeq.2_3'UTR|KCNK7_uc001oer.2_3'UTR|KCNK7_uc001oeu.2_3'UTR	NM_033347	NP_203133	Q9Y2U2	KCNK7_HUMAN	potassium channel, subfamily K, member 7 isoform	285	Cytoplasmic (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity				0						TCATCCTGCCCTAGGATGCCA	0.627			NA											3	16					0	0	1.23904e-05	0	0
MAP3K11	4296	broad.mit.edu	37	11	65380732	65380732	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:65380732G>C	uc001oew.2	-	1	989	c.496C>G	c.(496-498)CGG>GGG	p.R166G	MAP3K11_uc010rol.1_5'Flank	NM_002419	NP_002410	Q16584	M3K11_HUMAN	mitogen-activated protein kinase kinase kinase	166	Protein kinase.				activation of JUN kinase activity|cell proliferation|G1 phase of mitotic cell cycle|microtubule-based process|positive regulation of JNK cascade|protein autophosphorylation	centrosome|microtubule	ATP binding|JUN kinase kinase kinase activity|mitogen-activated protein kinase kinase kinase binding|protein homodimerization activity			breast(3)|lung(1)|central_nervous_system(1)|skin(1)	6						GCGAAGAGCCGGGCCTCCTGG	0.647			NA											3	59					0	0	6.4e-05	0	0
CARNS1	57571	broad.mit.edu	37	11	67191717	67191717	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:67191717A>T	uc009yrp.2	+	9	2581	c.2129A>T	c.(2128-2130)GAC>GTC	p.D710V	CARNS1_uc001olc.3_Missense_Mutation_p.D849V	NM_020811	NP_065862	A5YM72	CRNS1_HUMAN	ATP-grasp domain containing 1	710	ATP-grasp.				carnosine biosynthetic process		ATP binding|carnosine synthase activity|metal ion binding				0						TATGGTGTTGACCTGCTGCTG	0.632			NA											18	21					0	0	0.000229342	0	0
NUMA1	4926	broad.mit.edu	37	11	71733410	71733410	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:71733410C>G	uc001orl.1	-	7	519	c.347G>C	c.(346-348)TGG>TCG	p.W116S	NUMA1_uc001ork.1_Missense_Mutation_p.W116S|NUMA1_uc001orm.1_Missense_Mutation_p.W116S|NUMA1_uc009ysx.1_Missense_Mutation_p.W116S|NUMA1_uc001oro.1_Missense_Mutation_p.W116S|NUMA1_uc009ysy.1_Missense_Mutation_p.W116S|NUMA1_uc001orp.2_Missense_Mutation_p.W116S|NUMA1_uc001orq.2_Missense_Mutation_p.W116S	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	116					G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8						AAACTGTTCCCAGTCCCTGGG	0.493			NA	T	RARA	APL								6	210					0	0	0.000274275	0	0
ATG16L2	89849	broad.mit.edu	37	11	72540382	72540382	+	Missense_Mutation	SNP	G	G	C	rs142770133		TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:72540382G>C	uc001otd.2	+	18	1847	c.1807G>C	c.(1807-1809)GGG>CGG	p.G603R	ATG16L2_uc001ote.2_Missense_Mutation_p.G497R|ATG16L2_uc009ytj.1_Intron|ATG16L2_uc001otf.2_Missense_Mutation_p.G358R|ATG16L2_uc001otg.2_Missense_Mutation_p.G337R|ATG16L2_uc009ytk.2_Missense_Mutation_p.G324R	NM_033388	NP_203746	Q8NAA4	A16L2_HUMAN	ATG16 autophagy related 16-like 2	603	WD 7.				autophagy|protein transport	cytoplasm	protein binding				0			BRCA - Breast invasive adenocarcinoma(5;2.73e-06)			GTGCTACTCCGGGAGCCACAT	0.418			NA											3	36					0	0	6.4e-05	0	0
UVRAG	7405	broad.mit.edu	37	11	75727941	75727941	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:75727941C>G	uc001oxc.2	+	12	1384	c.1143C>G	c.(1141-1143)CCC>CCG	p.P381P	UVRAG_uc010rrw.1_Silent_p.P280P|UVRAG_uc001oxd.2_Silent_p.P9P|UVRAG_uc010rrx.1_Silent_p.P9P|UVRAG_uc009yuh.1_RNA	NM_003369	NP_003360	Q9P2Y5	UVRAG_HUMAN	UV radiation resistance associated	381					DNA repair|positive regulation of autophagy	early endosome|late endosome|lysosome	protein binding			skin(4)|lung(2)	6						TACAAGTGCCCCTCAGATATC	0.383			NA											4	140					0	0	0.00024832	0	0
ALG8	79053	broad.mit.edu	37	11	77832145	77832145	+	Silent	SNP	T	T	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:77832145T>C	uc001oza.1	-	4	509	c.444A>G	c.(442-444)TTA>TTG	p.L148L	ALG8_uc001oyz.1_Silent_p.L148L|ALG8_uc009yux.1_Silent_p.L46L|ALG8_uc009yuy.1_RNA	NM_024079	NP_076984	Q9BVK2	ALG8_HUMAN	dolichyl pyrophosphate Glc1Man9GlcNAc2	148	Helical; (Potential).				dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	endoplasmic reticulum membrane|integral to membrane	alpha-1,3-mannosyltransferase activity|dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity			ovary(2)|pancreas(1)	3	all_cancers(14;3.62e-19)|all_epithelial(13;1.27e-21)|Breast(9;8.51e-17)|Ovarian(111;0.152)		OV - Ovarian serous cystadenocarcinoma(8;9.66e-25)			TCCACAGAAGTAATACCGACA	0.323			NA											44	83					0	0	0.000147903	0	0
ANKRD42	338699	broad.mit.edu	37	11	82922342	82922342	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:82922342C>G	uc001ozz.1	+	5	794	c.372C>G	c.(370-372)CCC>CCG	p.P124P	ANKRD42_uc009yvi.1_Silent_p.P152P|ANKRD42_uc010rsv.1_Silent_p.P152P|ANKRD42_uc001paa.2_Silent_p.P152P|ANKRD42_uc001pab.1_Silent_p.P151P	NM_182603	NP_872409	Q8N9B4	ANR42_HUMAN	ankyrin repeat domain 42	124	ANK 3.									skin(1)	1						TCTAGGATCCCAGTGTGACTG	0.433			NA											6	162					0	0	0.000157383	0	0
NOX4	50507	broad.mit.edu	37	11	89070632	89070632	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:89070632G>C	uc001pct.2	-	16	1737	c.1498C>G	c.(1498-1500)CAA>GAA	p.Q500E	NOX4_uc009yvr.2_Missense_Mutation_p.Q475E|NOX4_uc001pcu.2_Missense_Mutation_p.Q426E|NOX4_uc001pcw.2_Missense_Mutation_p.Q193E|NOX4_uc001pcx.2_Missense_Mutation_p.Q153E|NOX4_uc001pcv.2_Missense_Mutation_p.Q460E|NOX4_uc009yvo.2_RNA|NOX4_uc010rtu.1_Missense_Mutation_p.Q313E|NOX4_uc009yvp.2_Missense_Mutation_p.Q264E|NOX4_uc010rtv.1_Missense_Mutation_p.Q436E|NOX4_uc009yvq.2_Missense_Mutation_p.Q476E	NM_016931	NP_058627	Q9NPH5	NOX4_HUMAN	NADPH oxidase 4 isoform a	500	Cytoplasmic (Potential).|Mediates interaction with TLR4.				cell aging|cell morphogenesis|inflammatory response|negative regulation of cell proliferation|superoxide anion generation	endoplasmic reticulum membrane|focal adhesion|integral to membrane|nucleus	electron carrier activity|flavin adenine dinucleotide binding|heme binding|NAD(P)H oxidase activity|nucleotide binding|oxygen sensor activity			ovary(1)|central_nervous_system(1)	2		Acute lymphoblastic leukemia(157;2.26e-05)|all_hematologic(158;0.011)				CCATCTGTTTGACTGAGGTAC	0.393			NA											21	37					0	0	0.000184323	0	0
CCDC67	159989	broad.mit.edu	37	11	93118683	93118683	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:93118683C>A	uc001pdq.2	+	8	1009	c.909C>A	c.(907-909)TGC>TGA	p.C303*	CCDC67_uc001pdo.1_Nonsense_Mutation_p.C303*|CCDC67_uc001pdp.2_Nonsense_Mutation_p.C303*	NM_181645	NP_857596	Q05D60	CCD67_HUMAN	coiled-coil domain containing 67	303										ovary(1)	1		Acute lymphoblastic leukemia(157;2.35e-05)|all_hematologic(158;0.00824)				TAGGAGAGTGCCAAAATGCTC	0.303			NA											21	59					7.92952e-12	1.8462e-10	7.16444e-05	1	0
AMOTL1	154810	broad.mit.edu	37	11	94599210	94599210	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:94599210C>T	uc001pfb.2	+	11	2535	c.2365C>T	c.(2365-2367)CGT>TGT	p.R789C	AMOTL1_uc001pfc.2_Missense_Mutation_p.R739C	NM_130847	NP_570899	Q8IY63	AMOL1_HUMAN	angiomotin like 1	789						cytoplasm|tight junction	identical protein binding			ovary(1)|breast(1)	2		Acute lymphoblastic leukemia(157;2.38e-05)|all_hematologic(158;0.00824)				CTCCAGCCTACGTCCTGCCCG	0.517			NA											19	29					0	0	9.7654e-05	0	0
MMP20	9313	broad.mit.edu	37	11	102477386	102477386	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:102477386C>T	uc001phc.2	-	6	846	c.833G>A	c.(832-834)GGG>GAG	p.G278E		NM_004771	NP_004762	O60882	MMP20_HUMAN	matrix metalloproteinase 20 preproprotein	278					proteolysis|regulation of enamel mineralization	extracellular space|proteinaceous extracellular matrix	calcium ion binding|metalloendopeptidase activity|protein binding|zinc ion binding			urinary_tract(1)|skin(1)	2	all_cancers(8;8.95e-05)|all_epithelial(12;0.00227)|Lung NSC(15;0.139)	Acute lymphoblastic leukemia(157;0.000967)|all_hematologic(158;0.0033)	Epithelial(9;0.0216)|Lung(13;0.0711)|all cancers(10;0.0889)|LUSC - Lung squamous cell carcinoma(19;0.13)	BRCA - Breast invasive adenocarcinoma(274;0.0161)		AGTGGGCTTCCCCAGGAATAC	0.537			NA											36	63					0	0	0.000319135	0	0
DYNC2H1	79659	broad.mit.edu	37	11	103027385	103027385	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:103027385A>T	uc001pho.2	+	26	4157	c.4013A>T	c.(4012-4014)TAC>TTC	p.Y1338F	DYNC2H1_uc001phn.1_Missense_Mutation_p.Y1338F|DYNC2H1_uc009yxe.1_Intron	NM_001080463	NP_001073932	Q8NCM8	DYHC2_HUMAN	dynein, cytoplasmic 2, heavy chain 1	1338	Stem (By similarity).				cell projection organization|Golgi organization|microtubule-based movement|multicellular organismal development	cilium axoneme|dynein complex|Golgi apparatus|microtubule|plasma membrane	ATP binding|ATPase activity|microtubule motor activity				0		Acute lymphoblastic leukemia(157;0.000966)|all_hematologic(158;0.00348)		BRCA - Breast invasive adenocarcinoma(274;0.000177)|Epithelial(105;0.0785)		TTAGATGAATACCTGCAGAAT	0.368			NA											17	32					0	0	0.000422831	0	0
ATM	472	broad.mit.edu	37	11	108204678	108204679	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:108204678_108204679CC>AA	uc001pkb.1	+	54	8378_8379	c.7993_7994CC>AA	c.(7993-7995)CCT>AAT	p.P2665N	ATM_uc009yxr.1_Missense_Mutation_p.P2665N|C11orf65_uc010rvx.1_Intron|C11orf65_uc009yxu.1_Intron|ATM_uc001pke.1_Missense_Mutation_p.P1317N|ATM_uc001pkg.1_Missense_Mutation_p.P1022N	NM_000051	NP_000042	Q13315	ATM_HUMAN	ataxia telangiectasia mutated isoform 1	2665					cell cycle arrest|cellular response to gamma radiation|DNA damage induced protein phosphorylation|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|double-strand break repair via homologous recombination|G2/M transition DNA damage checkpoint|histone mRNA catabolic process|mitotic cell cycle spindle assembly checkpoint|negative regulation of B cell proliferation|peptidyl-serine phosphorylation|positive regulation of DNA damage response, signal transduction by p53 class mediator|pre-B cell allelic exclusion|protein autophosphorylation|reciprocal meiotic recombination|replicative senescence	cytoplasmic membrane-bounded vesicle|nucleoplasm	1-phosphatidylinositol-3-kinase activity|ATP binding|DNA binding|DNA-dependent protein kinase activity|identical protein binding|protein complex binding|protein dimerization activity|protein N-terminus binding			haematopoietic_and_lymphoid_tissue(174)|lung(25)|breast(15)|large_intestine(9)|ovary(5)|kidney(5)|central_nervous_system(4)|upper_aerodigestive_tract(1)|stomach(1)|NS(1)	240		all_cancers(61;9.64e-12)|all_epithelial(67;9.97e-08)|Melanoma(852;2.55e-06)|Acute lymphoblastic leukemia(157;3.95e-05)|all_hematologic(158;0.00014)|Breast(348;0.0258)|all_neural(303;0.072)		Epithelial(105;9.05e-06)|BRCA - Breast invasive adenocarcinoma(274;1.06e-05)|all cancers(92;0.000208)|Colorectal(284;0.116)|OV - Ovarian serous cystadenocarcinoma(223;0.147)		TGTTGTTGTCCCTACTATGGAA	0.218			NA	D|Mis|N|F|S		T-PLL	leukemia|lymphoma|medulloblastoma|glioma		Genes_defective_in_diseases_associated_with_sensitivity_to_DNA_damaging_agents	Ataxia_Telangiectasia	TSP Lung(14;0.12)			9	323					0	0	6.4e-05	0	0
C11orf1	64776	broad.mit.edu	37	11	111754522	111754522	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:111754522C>G	uc001pmd.2	+	4	708	c.371C>G	c.(370-372)CCA>CGA	p.P124R	C11orf1_uc001pme.2_Missense_Mutation_p.P164R	NM_022761	NP_073598	Q9H5F2	CK001_HUMAN	hypothetical protein LOC64776	124						nucleus					0		all_cancers(61;1.26e-15)|all_epithelial(67;9.52e-10)|Melanoma(852;1.91e-06)|all_hematologic(158;0.000405)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0112)|Medulloblastoma(222;0.0228)|all_neural(223;0.0281)		all cancers(92;6.28e-09)|Epithelial(105;4.11e-08)|OV - Ovarian serous cystadenocarcinoma(223;1.52e-07)|BRCA - Breast invasive adenocarcinoma(274;1.1e-06)		CACTGGTTCCCAGGACATCAA	0.408			NA											5	167					0	0	3.59834e-05	0	0
CLDN25	644672	broad.mit.edu	37	11	113651086	113651086	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:113651086G>T	uc009yyw.1	+	1	569	c.569G>T	c.(568-570)GGA>GTA	p.G190V		NM_001101389	NP_001094859	C9JDP6	CLD25_HUMAN	claudin 25	190	Cytoplasmic (Potential).					integral to membrane|tight junction	structural molecule activity				0						GCCTGCCTGGGAAAAGAAGAT	0.557			NA											30	44					5.52252e-06	0.000120619	0.000339439	1	0
USP28	57646	broad.mit.edu	37	11	113711322	113711322	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:113711322G>A	uc001poh.2	-	5	565	c.532C>T	c.(532-534)CAG>TAG	p.Q178*	USP28_uc010rwy.1_Nonsense_Mutation_p.Q53*|USP28_uc001poi.2_5'UTR|USP28_uc001poj.3_Nonsense_Mutation_p.Q178*|USP28_uc010rwz.1_Nonsense_Mutation_p.Q178*	NM_020886	NP_065937	Q96RU2	UBP28_HUMAN	ubiquitin specific protease 28	178					cell proliferation|DNA damage checkpoint|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA repair|protein deubiquitination|response to ionizing radiation|ubiquitin-dependent protein catabolic process	nucleolus|nucleoplasm	protein binding|ubiquitin thiolesterase activity|ubiquitin-specific protease activity			lung(2)|breast(2)|ovary(1)|large_intestine(1)|kidney(1)	7		all_cancers(61;3.74e-18)|all_epithelial(67;3.75e-11)|Melanoma(852;1.46e-05)|all_hematologic(158;4.65e-05)|Acute lymphoblastic leukemia(157;0.000967)|Breast(348;0.0101)|Prostate(24;0.0153)|all_neural(223;0.0281)|Medulloblastoma(222;0.0425)		BRCA - Breast invasive adenocarcinoma(274;3.93e-06)|Epithelial(105;0.000122)|all cancers(92;0.00104)		TATCATACCTGAATAACAGCA	0.353	Melanoma(4;162 555 7664)|GBM(79;500 2010 17506)|Esophageal Squamous(9;463 924 15765)		NA											30	57					0	0	0.000491102	0	0
BACE1	23621	broad.mit.edu	37	11	117163813	117163813	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:117163813C>G	uc001pqz.2	-	5	1258	c.797G>C	c.(796-798)CGG>CCG	p.R266P	BACE1_uc001pqw.2_Missense_Mutation_p.R241P|BACE1_uc001pqx.2_Missense_Mutation_p.R197P|BACE1_uc001pqy.2_Missense_Mutation_p.R222P|BACE1_uc010rxg.1_Missense_Mutation_p.R141P|BACE1_uc010rxh.1_Missense_Mutation_p.R166P|BACE1_uc009yzo.1_5'Flank	NM_012104	NP_036236	P56817	BACE1_HUMAN	beta-site APP-cleaving enzyme 1 isoform A	266	Extracellular (Potential).				beta-amyloid metabolic process|membrane protein ectodomain proteolysis	cell surface|cytoplasmic vesicle membrane|endoplasmic reticulum|endosome|integral to plasma membrane|trans-Golgi network	aspartic-type endopeptidase activity|beta-aspartyl-peptidase activity|protein binding			ovary(1)	1	all_hematologic(175;0.0487)	Breast(348;0.00908)|Medulloblastoma(222;0.0425)|all_hematologic(192;0.196)|all_neural(223;0.234)		BRCA - Breast invasive adenocarcinoma(274;1.69e-05)|Epithelial(105;0.000563)|all cancers(92;0.0032)		GATCTCCACCCGCACAATGAT	0.502			NA											8	316					0	0	0.000274275	0	0
MPZL3	196264	broad.mit.edu	37	11	118106197	118106197	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:118106197C>G	uc001psm.2	-	4	561	c.559G>C	c.(559-561)GGG>CGG	p.G187R	MPZL3_uc010rxy.1_Missense_Mutation_p.G175R|MPZL3_uc010rxz.1_RNA|MPZL3_uc009yzy.2_Intron	NM_198275	NP_938016	Q6UWV2	MPZL3_HUMAN	myelin protein zero-like 3 precursor	187					cell adhesion	integral to membrane					0	all_hematologic(175;0.046)	Medulloblastoma(222;0.0523)|all_hematologic(192;0.232)		BRCA - Breast invasive adenocarcinoma(274;3.28e-05)		TTCTTCAGCCCAGCAGCCTTC	0.552			NA											5	232					0	0	3.59834e-05	0	0
TRIM29	23650	broad.mit.edu	37	11	120008375	120008375	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:120008375G>T	uc001pwz.2	-	1	489	c.365C>A	c.(364-366)GCC>GAC	p.A122D	TRIM29_uc001pxa.2_RNA	NM_012101	NP_036233	Q14134	TRI29_HUMAN	tripartite motif protein TRIM29	122					transcription from RNA polymerase II promoter	cytoplasm	protein binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(1)|breast(1)|kidney(1)|skin(1)	4		Breast(109;0.00117)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.37e-06)		GCCCTTTTCGGCAAAGGTAAC	0.617			NA											64	139					2.66076e-39	6.98703e-38	0.000147903	1	0
VSIG2	23584	broad.mit.edu	37	11	124618384	124618384	+	Silent	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:124618384C>A	uc001qas.2	-	6	829	c.753G>T	c.(751-753)CTG>CTT	p.L251L	VSIG2_uc001qat.2_Silent_p.L251L	NM_014312	NP_055127	Q96IQ7	VSIG2_HUMAN	V-set and immunoglobulin domain containing 2	251	Helical; (Potential).					integral to plasma membrane|membrane fraction				ovary(3)|central_nervous_system(1)	4	all_hematologic(175;0.215)	Breast(109;0.00663)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.118)|all_lung(97;0.126)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.49e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0215)		ACAGCACGCCCAGGAGCACCC	0.587			NA											27	41					2.47511e-08	5.58319e-07	0.000227799	1	0
CCDC15	80071	broad.mit.edu	37	11	124857163	124857163	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:124857163G>C	uc001qbm.3	+	8	1300	c.1041G>C	c.(1039-1041)CAG>CAC	p.Q347H		NM_025004	NP_079280	Q0P6D6	CCD15_HUMAN	coiled-coil domain containing 15	347						centrosome				ovary(1)|central_nervous_system(1)	2	all_hematologic(175;0.215)	Breast(109;0.00222)|Lung NSC(97;0.0177)|all_lung(97;0.0179)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;1.68e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0413)		TGGAAACCCAGGGTGATTTGA	0.473			NA											6	180					0	0	3.59834e-05	0	0
EI24	9538	broad.mit.edu	37	11	125448101	125448101	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:125448101G>T	uc001qca.2	+	6	631	c.389G>T	c.(388-390)TGG>TTG	p.W130L	EI24_uc001qcb.2_Missense_Mutation_p.W130L|EI24_uc010sbd.1_RNA|EI24_uc009zbl.2_Missense_Mutation_p.W130L|EI24_uc001qcc.2_RNA|EI24_uc010sbe.1_Missense_Mutation_p.W116L|EI24_uc010sbf.1_RNA	NM_004879	NP_004870	O14681	EI24_HUMAN	etoposide induced 2.4 isoform 1	130	Helical; (Potential).				apoptosis|autophagy|induction of apoptosis|negative regulation of cell growth	endoplasmic reticulum membrane|integral to membrane|nuclear membrane				ovary(1)	1	all_hematologic(175;0.228)	Breast(109;0.0021)|Lung NSC(97;0.0126)|all_lung(97;0.0132)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.64e-07)|OV - Ovarian serous cystadenocarcinoma(99;0.0975)		AGTGCTCTTTGGGTGCTCCCC	0.488			NA											8	160					1.12685e-05	0.000244952	0.000274275	1	0
STT3A	3703	broad.mit.edu	37	11	125488319	125488319	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:125488319G>A	uc001qcd.2	+	16	1936	c.1826G>A	c.(1825-1827)GGC>GAC	p.G609D	STT3A_uc001qce.2_Missense_Mutation_p.G609D|STT3A_uc010sbg.1_Missense_Mutation_p.G517D|STT3A_uc009zbn.2_Missense_Mutation_p.G331D	NM_152713	NP_689926	P46977	STT3A_HUMAN	integral membrane protein 1	609	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex	dolichyl-diphosphooligosaccharide-protein glycotransferase activity				0	all_hematologic(175;0.228)	Breast(109;0.0115)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0919)|all_lung(97;0.0994)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0996)		ACAGATACAGGCAAACATATC	0.443			NA											26	54					0	0	9.22233e-05	0	0
RPUSD4	84881	broad.mit.edu	37	11	126080928	126080928	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:126080928C>G	uc001qde.2	-	2	266	c.212G>C	c.(211-213)CGG>CCG	p.R71P	FAM118B_uc001qdf.2_5'Flank|FAM118B_uc009zca.2_5'Flank|FAM118B_uc001qdg.2_5'Flank|RPUSD4_uc009zbz.2_Missense_Mutation_p.R71P|RPUSD4_uc009zby.2_RNA	NM_032795	NP_116184	Q96CM3	RUSD4_HUMAN	RNA pseudouridylate synthase domain containing 4	71					pseudouridine synthesis		protein binding|pseudouridine synthase activity|RNA binding			breast(1)	1	all_hematologic(175;0.145)	Breast(109;0.00867)|Medulloblastoma(222;0.0523)|Lung NSC(97;0.0919)|all_lung(97;0.0994)|all_neural(223;0.224)		BRCA - Breast invasive adenocarcinoma(274;1.13e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0761)		TTGCACTCTCCGCTGAACAGC	0.572			NA											6	141					0	0	3.59834e-05	0	0
SPATA19	219938	broad.mit.edu	37	11	133715330	133715330	+	Silent	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr11:133715330C>A	uc001qgv.1	-	1	63	c.12G>T	c.(10-12)ACG>ACT	p.T4T		NM_174927	NP_777587	Q7Z5L4	SPT19_HUMAN	spermatogenesis associated 19 precursor	4					cell differentiation|multicellular organismal development|spermatogenesis	mitochondrial outer membrane					0	all_hematologic(175;0.127)	all_cancers(12;5.59e-17)|all_epithelial(12;2.65e-12)|all_lung(97;0.00045)|Lung NSC(97;0.000861)|Breast(109;0.000873)|Medulloblastoma(222;0.0425)|Esophageal squamous(93;0.0844)|all_neural(223;0.117)		Epithelial(10;4.36e-10)|all cancers(11;7.1e-09)|BRCA - Breast invasive adenocarcinoma(10;8.45e-09)|OV - Ovarian serous cystadenocarcinoma(99;0.00286)|Lung(977;0.207)		CAATCCATGTCGTAATTATCA	0.463			NA											23	55					9.86323e-18	2.39785e-16	7.16444e-05	1	0
IFFO1	25900	broad.mit.edu	37	12	6650692	6650692	+	Silent	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:6650692G>C	uc001qpd.1	-	8	1594	c.1560C>G	c.(1558-1560)ACC>ACG	p.T520T	IFFO1_uc001qoy.2_RNA|IFFO1_uc001qpa.1_Silent_p.T160T|IFFO1_uc001qpb.1_Silent_p.T197T|IFFO1_uc001qpe.1_RNA|IFFO1_uc010sfe.1_Silent_p.T532T|IFFO1_uc001qpf.1_Silent_p.T523T|IFFO1_uc001qoz.1_Silent_p.T161T|IFFO1_uc001qpc.1_Silent_p.T524T|IFFO1_uc001qpg.2_Silent_p.T161T	NM_080730	NP_542768	Q0D2I5	IFFO1_HUMAN	intermediate filament family orphan isoform 2	520						intermediate filament					0						CTCCAGACTGGGTGATGAGCC	0.637			NA											18	27					0	0	9.7654e-05	0	0
CHD4	1108	broad.mit.edu	37	12	6690214	6690214	+	Silent	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:6690214G>T	uc001qpo.2	-	33	5069	c.4905C>A	c.(4903-4905)CCC>CCA	p.P1635P	CHD4_uc001qpn.2_Silent_p.P1628P|CHD4_uc001qpp.2_Silent_p.P1660P|uc001qpq.1_Intron	NM_001273	NP_001264	Q14839	CHD4_HUMAN	chromodomain helicase DNA binding protein 4	1635	Required for interaction with PCNT.				chromatin modification|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	microtubule organizing center|NuRD complex	ATP binding|ATP-dependent DNA helicase activity|DNA binding|zinc ion binding			central_nervous_system(2)	2						CTTTACCTTTGGGCTCTGTCT	0.299	Colon(32;586 792 4568 16848 45314)		NA											15	327					0.000219431	0.00454042	0.000219431	1	0
GPR162	27239	broad.mit.edu	37	12	6936107	6936107	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:6936107G>C	uc001qqw.1	+	5	2040	c.1505G>C	c.(1504-1506)CGG>CCG	p.R502P	LEPREL2_uc001qqz.1_5'Flank|LEPREL2_uc001qra.1_5'Flank|LEPREL2_uc001qrb.1_5'Flank|GPR162_uc001qqx.1_Missense_Mutation_p.R218P|GPR162_uc009zfd.1_Missense_Mutation_p.R198P|GPR162_uc001qqy.1_Intron	NM_019858	NP_062832	Q16538	GP162_HUMAN	G protein-coupled receptor 162 isoform 2	502	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						GGCTTCTTCCGGGAGGAGATC	0.657			NA											4	160					0	0	3.59834e-05	0	0
ITPR2	3709	broad.mit.edu	37	12	26568412	26568412	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:26568412C>G	uc001rhg.2	-	51	7547	c.7130G>C	c.(7129-7131)AGG>ACG	p.R2377T	ITPR2_uc009zjg.1_Missense_Mutation_p.R528T	NM_002223	NP_002214	Q14571	ITPR2_HUMAN	inositol 1,4,5-triphosphate receptor, type 2	2377	Cytoplasmic (Potential).				activation of phospholipase C activity|energy reserve metabolic process|nerve growth factor receptor signaling pathway|platelet activation|regulation of insulin secretion|response to hypoxia	integral to membrane|plasma membrane enriched fraction|platelet dense tubular network membrane|sarcoplasmic reticulum membrane	calcium ion transmembrane transporter activity|inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity			kidney(6)|ovary(4)|skin(2)|upper_aerodigestive_tract(1)|lung(1)	14	Colorectal(261;0.0847)					AGTCTCTTCCCTGTACACCAA	0.368			NA											4	125					0	0	1.23904e-05	0	0
KLHDC5	57542	broad.mit.edu	37	12	27933611	27933611	+	Silent	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:27933611C>T	uc001rij.2	+	1	425	c.348C>T	c.(346-348)TCC>TCT	p.S116S	KLHDC5_uc009zjj.2_RNA	NM_020782	NP_065833	Q9P2K6	KLDC5_HUMAN	kelch domain containing 5	116										ovary(1)|central_nervous_system(1)	2	Lung SC(9;0.0873)					AGGTCACGTCCCTGCTGCAGC	0.677			NA											19	55					0	0	0.000295444	0	0
TMTC1	83857	broad.mit.edu	37	12	29911698	29911698	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:29911698C>T	uc001rjb.2	-	3	643	c.169G>A	c.(169-171)GTT>ATT	p.V57I	TMTC1_uc001rjc.1_Missense_Mutation_p.V57I	NM_175861	NP_787057	Q8IUR5	TMTC1_HUMAN	transmembrane and tetratricopeptide repeat	165	Helical; (Potential).					integral to membrane	binding				0	Lung NSC(12;7.61e-10)|Acute lymphoblastic leukemia(23;0.0122)|all_hematologic(23;0.032)					GCTCTGCCAACGATCCCAGCC	0.393			NA											17	28					0	0	0.000175454	0	0
CNTN1	1272	broad.mit.edu	37	12	41316191	41316191	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:41316191G>C	uc001rmm.1	+	5	474	c.361G>C	c.(361-363)GGG>CGG	p.G121R	CNTN1_uc009zjy.1_Missense_Mutation_p.G121R|CNTN1_uc001rmn.1_Missense_Mutation_p.G110R|CNTN1_uc001rmo.2_Missense_Mutation_p.G121R	NM_001843	NP_001834	Q12860	CNTN1_HUMAN	contactin 1 isoform 1 precursor	121	Ig-like C2-type 1.				axon guidance|cell adhesion|Notch signaling pathway	anchored to membrane|membrane fraction|plasma membrane				lung(4)|ovary(3)|large_intestine(1)|skin(1)	9	all_cancers(12;2.07e-06)|all_epithelial(1;4.26e-06)|Breast(8;0.0716)	Lung NSC(34;0.0211)|all_lung(34;0.0294)				TAATAACTACGGGATGGTCAG	0.398			NA											4	66					0	0	1.23904e-05	0	0
TMEM117	84216	broad.mit.edu	37	12	44693440	44693441	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:44693440_44693441GG>TT	uc001rod.2	+	6	752_753	c.686_687GG>TT	c.(685-687)CGG>CTT	p.R229L	TMEM117_uc001roe.2_Missense_Mutation_p.R125L|TMEM117_uc009zkc.2_Missense_Mutation_p.R229L	NM_032256	NP_115632	Q9H0C3	TM117_HUMAN	transmembrane protein 117	229						endoplasmic reticulum|integral to membrane					0	Lung SC(27;0.192)			GBM - Glioblastoma multiforme(48;0.124)		AAGCTGAATCGGGGATTTTTGC	0.436			NA											8	222					0	0	6.4e-05	0	0
ARID2	196528	broad.mit.edu	37	12	46230610	46230610	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:46230610C>A	uc001ros.1	+	8	859	c.859C>A	c.(859-861)CTT>ATT	p.L287I	ARID2_uc001ror.2_Missense_Mutation_p.L287I|ARID2_uc009zkg.1_5'UTR|ARID2_uc009zkh.1_5'Flank|ARID2_uc001rot.1_5'UTR	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	287					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		ACAGCGGGTACTTCAGATTGC	0.413			NA											41	73					2.95478e-19	7.28633e-18	0.000374591	1	0
MLL2	8085	broad.mit.edu	37	12	49445233	49445233	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:49445233G>A	uc001rta.3	-	10	2233	c.2233C>T	c.(2233-2235)CCC>TCC	p.P745S		NM_003482	NP_003473	O14686	MLL2_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 2	745	Pro-rich.			Missing (in Ref. 1; AAC51734).	chromatin silencing|histone H3-K4 methylation|oocyte growth|positive regulation of cell proliferation|positive regulation of estrogen receptor signaling pathway|positive regulation of transcription from RNA polymerase II promoter|response to estrogen stimulus|transcription, DNA-dependent	histone methyltransferase complex	histone-lysine N-methyltransferase activity|protein binding|transcription regulatory region DNA binding|zinc ion binding			kidney(16)|central_nervous_system(12)|lung(4)|skin(4)|ovary(3)|pancreas(2)	41						TCAGGCCGGGGTGACAGGTGC	0.697			NA	N|F|Mis		medulloblastoma|renal					HNSCC(34;0.089)			12	29					0	0	0.000219431	0	0
FAM186B	84070	broad.mit.edu	37	12	49981528	49981528	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:49981528C>T	uc001ruo.2	-	7	2715	c.2542G>A	c.(2542-2544)GGG>AGG	p.G848R	FAM186B_uc010smk.1_Intron	NM_032130	NP_115506	Q8IYM0	F186B_HUMAN	hypothetical protein LOC84070	848						protein complex				ovary(1)	1						ATCTGCTTCCCCTGTTGGCTG	0.557			NA											17	22					0	0	9.7654e-05	0	0
NCKAP5L	57701	broad.mit.edu	37	12	50189231	50189231	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:50189231C>G	uc009zlk.2	-	8	2614	c.2412G>C	c.(2410-2412)CTG>CTC	p.L804L	NCKAP5L_uc001rvc.3_Silent_p.L8L|NCKAP5L_uc001rvb.2_Silent_p.L397L	NM_001037806	NP_001032895	Q9HCH0	NCK5L_HUMAN	NCK-associated protein 5-like	800	Pro-rich.									central_nervous_system(1)	1						TGGGCTTGCCCAGGCTTGGGG	0.652			NA											4	54					0	0	1.23904e-05	0	0
SLC4A8	9498	broad.mit.edu	37	12	51888800	51888800	+	Silent	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:51888800G>C	uc001rys.1	+	21	3019	c.2841G>C	c.(2839-2841)GTG>GTC	p.V947V	SLC4A8_uc001rym.2_Silent_p.V894V|SLC4A8_uc001ryn.2_Silent_p.V894V|SLC4A8_uc001ryo.2_Silent_p.V894V|SLC4A8_uc010snj.1_Silent_p.V974V|SLC4A8_uc001ryr.2_Silent_p.V947V	NM_001039960	NP_001035049	Q2Y0W8	S4A8_HUMAN	solute carrier family 4, sodium bicarbonate	947	Extracellular (Potential).				bicarbonate transport|sodium ion transport	integral to membrane|plasma membrane	inorganic anion exchanger activity			ovary(3)|pancreas(1)|skin(1)	5				BRCA - Breast invasive adenocarcinoma(357;0.15)		TGCGGCATGTGCCGCTGCGCA	0.507			NA											39	70					0	0	0.000270559	0	0
SCN8A	6334	broad.mit.edu	37	12	52159702	52159702	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:52159702G>T	uc001ryw.2	+	16	2970	c.2792G>T	c.(2791-2793)CGA>CTA	p.R931L	SCN8A_uc010snl.1_Missense_Mutation_p.R796L|SCN8A_uc001ryy.2_Missense_Mutation_p.R796L	NM_014191	NP_055006	Q9UQD0	SCN8A_HUMAN	sodium channel, voltage gated, type VIII, alpha	931	II.				axon guidance|myelination|peripheral nervous system development	cytoplasmic membrane-bounded vesicle|node of Ranvier	ATP binding|voltage-gated sodium channel activity			ovary(7)	7				BRCA - Breast invasive adenocarcinoma(357;0.181)	Lamotrigine(DB00555)	ATTGTCTTTCGAGTGTTGTGC	0.498			NA											8	282					0.000442599	0.00887779	0.000442599	1	0
ESPL1	9700	broad.mit.edu	37	12	53682997	53682997	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:53682997G>C	uc001sck.2	+	21	4923	c.4832G>C	c.(4831-4833)CGG>CCG	p.R1611P	ESPL1_uc001scj.2_Missense_Mutation_p.R1286P	NM_012291	NP_036423	Q14674	ESPL1_HUMAN	separase	1611					apoptosis|cytokinesis|establishment of mitotic spindle localization|mitotic sister chromatid segregation|negative regulation of sister chromatid cohesion|positive regulation of mitotic metaphase/anaphase transition|proteolysis	centrosome|nucleus	cysteine-type peptidase activity|protein binding			lung(1)|kidney(1)|skin(1)	3						CTGGGCCACCGGGATCCTTAT	0.602	Colon(53;1069 1201 2587 5382)		NA											4	164					0	0	0.00024832	0	0
NCKAP1L	3071	broad.mit.edu	37	12	54925050	54925050	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:54925050G>C	uc001sgc.3	+	23	2592	c.2513G>C	c.(2512-2514)CGG>CCG	p.R838P	NCKAP1L_uc010sox.1_Missense_Mutation_p.R380P|NCKAP1L_uc010soy.1_Missense_Mutation_p.R788P	NM_005337	NP_005328	P55160	NCKPL_HUMAN	NCK-associated protein 1-like	838					actin polymerization-dependent cell motility|B cell homeostasis|B cell receptor signaling pathway|cortical actin cytoskeleton organization|erythrocyte development|maintenance of cell polarity|myeloid cell homeostasis|negative regulation of apoptosis|negative regulation of interleukin-17 production|negative regulation of interleukin-6 production|negative regulation of myosin-light-chain-phosphatase activity|neutrophil chemotaxis|positive regulation of actin filament polymerization|positive regulation of B cell differentiation|positive regulation of B cell proliferation|positive regulation of CD4-positive, alpha-beta T cell differentiation|positive regulation of CD8-positive, alpha-beta T cell differentiation|positive regulation of cell adhesion mediated by integrin|positive regulation of erythrocyte differentiation|positive regulation of gamma-delta T cell differentiation|positive regulation of neutrophil chemotaxis|positive regulation of phagocytosis, engulfment|positive regulation of T cell proliferation|protein complex assembly|response to drug|T cell homeostasis	cytosol|integral to plasma membrane|membrane fraction|SCAR complex	protein complex binding|protein kinase activator activity|Rac GTPase activator activity			ovary(3)|central_nervous_system(1)	4						CCAGAGATGCGGGCCTTGGCA	0.473			NA											5	235					0	0	1.23904e-05	0	0
PA2G4	5036	broad.mit.edu	37	12	56500978	56500979	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:56500978_56500979GG>TT	uc001sjm.2	+	4	750_751	c.331_332GG>TT	c.(331-333)GGG>TTG	p.G111L	PA2G4_uc009zol.2_Missense_Mutation_p.G111L|PA2G4_uc009zom.2_Missense_Mutation_p.G111L	NM_006191	NP_006182	Q9UQ80	PA2G4_HUMAN	ErbB3-binding protein 1	111					cell cycle arrest|cell proliferation|negative regulation of transcription, DNA-dependent|regulation of translation|rRNA processing	cytoplasm|nucleolus|ribonucleoprotein complex	DNA binding|RNA binding|sequence-specific DNA binding transcription factor activity|ubiquitin protein ligase binding				0			OV - Ovarian serous cystadenocarcinoma(18;0.0739)			CAGTGACCTTGGGGTCCATGTG	0.416			NA											10	218					0	0	6.4e-05	0	0
PAN2	9924	broad.mit.edu	37	12	56713245	56713245	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:56713245C>G	uc001skx.2	-	23	3502	c.3129G>C	c.(3127-3129)TCG>TCC	p.S1043S	PAN2_uc001skw.2_Silent_p.S191S|PAN2_uc001skz.2_Silent_p.S1042S|PAN2_uc001sky.2_Silent_p.S1039S	NM_001127460	NP_001120932	Q504Q3	PAN2_HUMAN	PAN2 polyA specific ribonuclease subunit homolog	1043	Exonuclease.				nuclear-transcribed mRNA catabolic process, nonsense-mediated decay|nuclear-transcribed mRNA poly(A) tail shortening|ubiquitin-dependent protein catabolic process	cytosol|nucleus	nucleic acid binding|poly(A)-specific ribonuclease activity|ubiquitin thiolesterase activity			ovary(2)|skin(2)|large_intestine(1)|breast(1)	6						GCTTTATACCCGAGTATTGAG	0.443			NA											4	122					0	0	3.59834e-05	0	0
MYO1A	4640	broad.mit.edu	37	12	57440845	57440845	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:57440845A>T	uc001smw.3	-	6	720	c.477T>A	c.(475-477)TTT>TTA	p.F159L	MYO1A_uc010sqz.1_Intron|MYO1A_uc009zpd.2_Missense_Mutation_p.F159L	NM_005379	NP_005370	Q9UBC5	MYO1A_HUMAN	myosin IA	159	Myosin head-like.				sensory perception of sound|vesicle localization	brush border|cortical actin cytoskeleton|filamentous actin|lateral plasma membrane|microvillus|myosin complex	actin binding|ATP binding|calmodulin binding|motor activity			skin(4)|ovary(2)|urinary_tract(1)	7						ATTTACTCACAAATCGGGAGG	0.522			NA											15	29					0	0	5.01169e-05	0	0
STAC3	246329	broad.mit.edu	37	12	57642836	57642836	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:57642836G>C	uc001snp.2	-	3	517	c.322C>G	c.(322-324)CGG>GGG	p.R108G	STAC3_uc009zpl.2_Intron|STAC3_uc001snq.2_Missense_Mutation_p.R69G|STAC3_uc010srm.1_Intron	NM_145064	NP_659501	Q96MF2	STAC3_HUMAN	SH3 and cysteine rich domain 3	108	Phorbol-ester/DAG-type.				intracellular signal transduction		identical protein binding|metal ion binding			ovary(2)|skin(1)	3						ACAATCATCCGGGCACAGACA	0.458			NA											5	100					0	0	1.23904e-05	0	0
SLC26A10	65012	broad.mit.edu	37	12	58014048	58014049	+	Nonsense_Mutation	DNP	GG	GG	TT			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:58014048_58014049GG>TT	uc001spe.2	+	1	356_357	c.45_46GG>TT	c.(43-48)CTGGGA>CTTTGA	p.G16*	uc001spc.2_5'Flank|SLC26A10_uc001spf.2_RNA	NM_133489	NP_597996	Q8NG04	S2610_HUMAN	solute carrier family 26, member 10	16						integral to membrane	antiporter activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(17;0.122)					CTAAGAGTCTGGGAAGTGCATT	0.535			NA											12	231					0	0	6.4e-05	0	0
AVIL	10677	broad.mit.edu	37	12	58191674	58191674	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:58191674C>G	uc001sqj.1	-	19	2480	c.2451G>C	c.(2449-2451)GGG>GGC	p.G817G	AVIL_uc009zqe.1_Silent_p.G810G	NM_006576	NP_006567	O75366	AVIL_HUMAN	advillin	817	Headpiece (By similarity).|HP.				actin filament capping|cilium morphogenesis|cytoskeleton organization|positive regulation of neuron projection development	actin cytoskeleton|axon|cytoplasm	actin binding			central_nervous_system(1)	1	Glioma(12;6.95e-05)|all_neural(12;0.00016)|Melanoma(17;0.122)					TTTAGAAAAGCCCCTTTTCTT	0.443			NA											22	64					0	0	0.000229342	0	0
SYT1	6857	broad.mit.edu	37	12	79689968	79689968	+	Silent	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:79689968C>A	uc001sys.2	+	8	1265	c.594C>A	c.(592-594)GTC>GTA	p.V198V	SYT1_uc001syt.2_Silent_p.V198V|SYT1_uc001syu.2_Silent_p.V195V|SYT1_uc001syv.2_Silent_p.V198V	NM_001135805	NP_001129277	P21579	SYT1_HUMAN	synaptotagmin I	198	Cytoplasmic (Potential).|Phospholipid binding (Probable).|C2 1.				detection of calcium ion|glutamate secretion|neurotransmitter secretion|protein homooligomerization	cell junction|chromaffin granule membrane|clathrin sculpted acetylcholine transport vesicle membrane|clathrin sculpted gamma-aminobutyric acid transport vesicle membrane|clathrin sculpted glutamate transport vesicle membrane|clathrin sculpted monoamine transport vesicle membrane|endocytic vesicle membrane|integral to membrane|synaptic vesicle membrane	1-phosphatidylinositol binding|low-density lipoprotein particle receptor binding|metal ion binding|syntaxin-1 binding|transporter activity			skin(3)|pancreas(2)|ovary(1)	6						AGACAAAAGTCCACCGAAAAA	0.388			NA											27	55					1.12875e-08	2.55875e-07	0.000147802	1	0
POLR3B	55703	broad.mit.edu	37	12	106763120	106763121	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:106763120_106763121CC>AA	uc001tlp.2	+	5	517_518	c.295_296CC>AA	c.(295-297)CCT>AAT	p.P99N	POLR3B_uc001tlq.2_Missense_Mutation_p.P41N	NM_018082	NP_060552	Q9NW08	RPC2_HUMAN	DNA-directed RNA polymerase III B isoform 1	99					innate immune response|positive regulation of innate immune response|positive regulation of interferon-beta production|response to virus|termination of RNA polymerase III transcription|transcription elongation from RNA polymerase III promoter	nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|ribonucleoside binding			ovary(1)|central_nervous_system(1)	2						ACCAGTGTCCCCTCATGAGGTA	0.337			NA											10	336					0	0	6.4e-05	0	0
ACACB	32	broad.mit.edu	37	12	109690858	109690858	+	Silent	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:109690858G>C	uc001tob.2	+	43	6059	c.5940G>C	c.(5938-5940)CTG>CTC	p.L1980L	ACACB_uc001toc.2_Silent_p.L1980L|ACACB_uc010sxl.1_RNA|ACACB_uc001tod.2_RNA|ACACB_uc010sxm.1_Silent_p.L646L	NM_001093	NP_001084	O00763	ACACB_HUMAN	acetyl-Coenzyme A carboxylase beta	1980	Carboxyltransferase.				acetyl-CoA metabolic process|carnitine shuttle|energy reserve metabolic process|fatty acid biosynthetic process|positive regulation of cellular metabolic process|protein homotetramerization|regulation of fatty acid oxidation	cytosol|endomembrane system|Golgi apparatus|membrane	acetyl-CoA carboxylase activity|ATP binding|biotin carboxylase activity|metal ion binding|protein binding			ovary(5)|upper_aerodigestive_tract(1)|pancreas(1)|skin(1)	8					Biotin(DB00121)	ACAACCAGCTGGGTGGCGTTC	0.522			NA											6	180					0	0	0.000157383	0	0
RBM19	9904	broad.mit.edu	37	12	114395815	114395815	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:114395815C>A	uc009zwi.2	-	6	756	c.612G>T	c.(610-612)GAG>GAT	p.E204D	RBM19_uc001tvn.3_Missense_Mutation_p.E204D|RBM19_uc001tvm.2_Missense_Mutation_p.E204D	NM_001146699	NP_001140171	Q9Y4C8	RBM19_HUMAN	RNA binding motif protein 19	204					multicellular organismal development|positive regulation of embryonic development	chromosome|cytoplasm|nucleolus|nucleoplasm	nucleotide binding|RNA binding			skin(3)|ovary(1)|liver(1)|central_nervous_system(1)	6	Medulloblastoma(191;0.163)|all_neural(191;0.178)					TGTCCGACAGCTCCTTCTGCA	0.527			NA											43	71					7.05121e-23	1.77052e-21	0.000509022	1	0
GCN1L1	10985	broad.mit.edu	37	12	120578771	120578771	+	Silent	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:120578771G>T	uc001txo.2	-	45	5899	c.5886C>A	c.(5884-5886)CCC>CCA	p.P1962P		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	1962	HEAT 16.				regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					GGATGATCTCGGGGAGGATTT	0.527			NA											6	159					0.000157383	0.00327129	0.000157383	1	0
C12orf43	64897	broad.mit.edu	37	12	121442869	121442869	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:121442869G>A	uc001tzh.1	-	5	412	c.389C>T	c.(388-390)CCT>CTT	p.P130L	C12orf43_uc009zxa.1_Missense_Mutation_p.P161L|C12orf43_uc010szo.1_Missense_Mutation_p.P88L|C12orf43_uc010szp.1_Intron|C12orf43_uc001tzi.1_Missense_Mutation_p.P130L	NM_022895	NP_075046	Q96C57	CL043_HUMAN	hypothetical protein LOC64897	130											0	all_neural(191;0.0684)|Medulloblastoma(191;0.0922)					ACGGCCTCCAGGGACAGAtgt	0.328			NA											7	14					0	0	0.000157383	0	0
MLXIP	22877	broad.mit.edu	37	12	122614649	122614649	+	Silent	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:122614649C>T	uc001ubq.2	+	6	900	c.900C>T	c.(898-900)CCC>CCT	p.P300P	MLXIP_uc001ubr.2_Silent_p.P51P|MLXIP_uc001ubs.1_5'Flank	NM_014938	NP_055753	Q9HAP2	MLXIP_HUMAN	MLX interacting protein	300	Required for cytoplasmic localization.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	mitochondrial outer membrane|nucleus	DNA binding			ovary(2)	2	all_neural(191;0.0837)|Medulloblastoma(191;0.163)	Lung NSC(355;0.0659)		OV - Ovarian serous cystadenocarcinoma(86;0.000599)|Epithelial(86;0.00102)|BRCA - Breast invasive adenocarcinoma(302;0.233)		GGCCCAATCCCCGGGAAATAG	0.602	Esophageal Squamous(105;787 1493 16200 18566 52466)		NA											7	9					0	0	0.000157383	0	0
PITPNM2	57605	broad.mit.edu	37	12	123481914	123481914	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:123481914G>C	uc001uej.1	-	10	1569	c.1430C>G	c.(1429-1431)CCC>CGC	p.P477R	PITPNM2_uc001uek.1_Missense_Mutation_p.P477R	NM_020845	NP_065896	Q9BZ72	PITM2_HUMAN	phosphatidylinositol transfer protein,	477					metabolic process|transport	endomembrane system|integral to membrane|intracellular membrane-bounded organelle	calcium ion binding|lipid binding			ovary(1)|central_nervous_system(1)|skin(1)	3	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;2.55e-05)|Epithelial(86;8.43e-05)|BRCA - Breast invasive adenocarcinoma(302;0.123)		GGGCGGGCAGGGCACCAGGCG	0.647			NA											21	54					0	0	9.22233e-05	0	0
DDX55	57696	broad.mit.edu	37	12	124104073	124104073	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:124104073C>G	uc001ufi.2	+	13	1452	c.1428C>G	c.(1426-1428)CCC>CCG	p.P476P	DDX55_uc001ufh.2_3'UTR|DDX55_uc001ufk.2_Silent_p.P329P|DDX55_uc001ufl.2_Silent_p.P83P	NM_020936	NP_065987	Q8NHQ9	DDX55_HUMAN	DEAD (Asp-Glu-Ala-Asp) box polypeptide 55	476							ATP binding|ATP-dependent helicase activity|RNA binding			ovary(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;0.000142)|Epithelial(86;0.000637)|all cancers(50;0.00772)		ATTTTGTGCCCGTGGACGTTA	0.403			NA											4	146					0	0	0.00024832	0	0
DHX37	57647	broad.mit.edu	37	12	125444911	125444911	+	Missense_Mutation	SNP	G	G	C	rs114212811	by1000genomes	TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:125444911G>C	uc001ugy.2	-	16	2203	c.2104C>G	c.(2104-2106)CGG>GGG	p.R702G		NM_032656	NP_116045	Q8IY37	DHX37_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 37	702	Helicase C-terminal.						ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;8.05e-05)|Epithelial(86;0.000486)|all cancers(50;0.00653)		ACAGGCCTCCGGGTGATTTCT	0.527			NA											5	134					0	0	0.000157383	0	0
FZD10	11211	broad.mit.edu	37	12	130647907	130647907	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:130647907G>T	uc001uii.2	+	1	876	c.420G>T	c.(418-420)AAG>AAT	p.K140N	uc001uig.1_5'Flank|uc001uih.1_5'Flank	NM_007197	NP_009128	Q9ULW2	FZD10_HUMAN	frizzled 10 precursor	140	FZ.|Extracellular (Potential).				brain development|canonical Wnt receptor signaling pathway|cellular response to retinoic acid|embryo development|gonad development|negative regulation of Rho GTPase activity|neuron differentiation|non-canonical Wnt receptor signaling pathway|positive regulation of JUN kinase activity|positive regulation of Rac GTPase activity|regulation of actin cytoskeleton organization|vasculature development	cell projection|cell surface|cytoplasm|integral to plasma membrane	G-protein coupled receptor activity|PDZ domain binding|Wnt receptor activity|Wnt-protein binding			lung(3)|breast(1)|central_nervous_system(1)	5	all_neural(191;0.101)|Medulloblastoma(191;0.163)			OV - Ovarian serous cystadenocarcinoma(86;1.3e-06)|Epithelial(86;1.66e-05)|all cancers(50;5.18e-05)		TCCCCAACAAGAACGACCCCA	0.662			NA											34	71					8.01111e-26	2.04135e-24	0.000509022	1	0
POLE	5426	broad.mit.edu	37	12	133220441	133220441	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:133220441C>A	uc001uks.1	-	33	4316	c.4272G>T	c.(4270-4272)GAG>GAT	p.E1424D	POLE_uc001ukq.1_5'Flank|POLE_uc001ukr.1_Missense_Mutation_p.E228D|POLE_uc010tbq.1_RNA|POLE_uc009zyu.1_Missense_Mutation_p.E1397D	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	1424					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		CATATACGCCCTCGATGTCTG	0.557			NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					19	17					5.3912e-06	0.000118126	7.07596e-05	1	0
POLE	5426	broad.mit.edu	37	12	133245001	133245001	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:133245001C>G	uc001uks.1	-	19	2158	c.2114G>C	c.(2113-2115)CGG>CCG	p.R705P	POLE_uc010tbq.1_RNA|POLE_uc009zyu.1_Missense_Mutation_p.R678P	NM_006231	NP_006222	Q07864	DPOE1_HUMAN	DNA-directed DNA polymerase epsilon	705					base-excision repair, gap-filling|DNA synthesis involved in DNA repair|DNA-dependent DNA replication initiation|G1/S transition of mitotic cell cycle|M/G1 transition of mitotic cell cycle|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	chromatin binding|DNA binding|DNA-directed DNA polymerase activity|nucleotide binding|protein binding|zinc ion binding			ovary(3)|skin(3)|lung(1)|central_nervous_system(1)	8	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0416)		OV - Ovarian serous cystadenocarcinoma(86;5.22e-08)|Epithelial(86;4.03e-07)|all cancers(50;1.18e-05)		ATGAAAGGCCCGAGCTGGCCC	0.607			NA						DNA_polymerases_(catalytic_subunits)|Direct_reversal_of_damage					4	113					0	0	0.00024832	0	0
GOLGA3	2802	broad.mit.edu	37	12	133358952	133358952	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:133358952C>G	uc001ukz.1	-	17	3954	c.3395G>C	c.(3394-3396)CGG>CCG	p.R1132P	GOLGA3_uc001ula.1_Missense_Mutation_p.R1132P	NM_005895	NP_005886	Q08378	GOGA3_HUMAN	Golgi autoantigen, golgin subfamily a, 3	1132	Potential.				intra-Golgi vesicle-mediated transport	Golgi cisterna membrane|Golgi transport complex	protein binding|transporter activity			ovary(3)|central_nervous_system(2)|pancreas(1)	6	all_neural(191;0.0982)|Medulloblastoma(191;0.163)	all_epithelial(31;0.0176)|Lung NSC(355;0.204)		OV - Ovarian serous cystadenocarcinoma(86;2.27e-08)|Epithelial(86;3.34e-07)|all cancers(50;9.4e-06)		GTTGTGTTCCCGCAGAGCTGC	0.502			NA											5	216					0	0	3.59834e-05	0	0
ATP8A2	51761	broad.mit.edu	37	13	26138096	26138096	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr13:26138096G>T	uc001uqk.2	+	16	1542	c.1400G>T	c.(1399-1401)CGG>CTG	p.R467L	ATP8A2_uc010tdi.1_Missense_Mutation_p.R427L|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc001uql.1_Missense_Mutation_p.R427L	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	427	Cytoplasmic (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		TCTTACAGTCGGATGCCTCCT	0.413			NA											6	93					8.12818e-05	0.00171015	8.12818e-05	1	0
GPR12	2835	broad.mit.edu	37	13	27333871	27333871	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr13:27333871G>C	uc010aal.2	-	2	316	c.94C>G	c.(94-96)CGG>GGG	p.R32G	GPR12_uc010tdl.1_Intron	NM_005288	NP_005279	P47775	GPR12_HUMAN	G protein-coupled receptor 12	32	Extracellular (Potential).					integral to plasma membrane					0	Colorectal(5;5.77e-05)	Breast(139;0.198)		Epithelial(112;9.37e-07)|OV - Ovarian serous cystadenocarcinoma(117;1.16e-06)|all cancers(112;8.31e-06)|GBM - Glioblastoma multiforme(144;0.00121)|Lung(94;0.111)|LUSC - Lung squamous cell carcinoma(192;0.184)		GCAGGAACCCGGGAGGAGACA	0.532			NA											4	82					0	0	1.23904e-05	0	0
FLT3	2322	broad.mit.edu	37	13	28623785	28623785	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr13:28623785T>G	uc001urw.2	-	7	951	c.869A>C	c.(868-870)AAA>ACA	p.K290T	FLT3_uc010aao.2_RNA|FLT3_uc010tdn.1_Missense_Mutation_p.K290T	NM_004119	NP_004110	P36888	FLT3_HUMAN	fms-related tyrosine kinase 3 precursor	290	Extracellular (Potential).|Ig-like C2-type.				positive regulation of cell proliferation	integral to plasma membrane	ATP binding|vascular endothelial growth factor receptor activity			haematopoietic_and_lymphoid_tissue(8536)|lung(7)|ovary(3)|stomach(1)|central_nervous_system(1)|skin(1)	8549	Acute lymphoblastic leukemia(6;0.04)	Lung SC(185;0.0156)|Ovarian(182;0.0392)	Colorectal(13;0.000157)|READ - Rectum adenocarcinoma(15;0.105)	OV - Ovarian serous cystadenocarcinoma(117;0.00154)|all cancers(112;0.00459)|GBM - Glioblastoma multiforme(144;0.00562)|Epithelial(112;0.0959)|Lung(94;0.212)	Sorafenib(DB00398)|Sunitinib(DB01268)	CTCGAGTGCTTTGTTTTCTAA	0.373			NA	Mis|O		AML|ALL								49	92					0	0	0.000147903	0	0
RXFP2	122042	broad.mit.edu	37	13	32376489	32376489	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr13:32376489G>T	uc001utt.2	+	18	2283	c.2212G>T	c.(2212-2214)GGG>TGG	p.G738W	RXFP2_uc010aba.2_Missense_Mutation_p.G697W	NM_130806	NP_570718	Q8WXD0	RXFP2_HUMAN	relaxin/insulin-like family peptide receptor 2	738	Cytoplasmic (Potential).					integral to membrane|plasma membrane					0		Lung SC(185;0.0262)		all cancers(112;0.000559)|Epithelial(112;0.0017)|OV - Ovarian serous cystadenocarcinoma(117;0.0145)|BRCA - Breast invasive adenocarcinoma(63;0.0535)		CCTGAAACTTGGGGTTTTGAA	0.373			NA											13	416					7.07596e-05	0.00149793	7.07596e-05	1	0
FRY	10129	broad.mit.edu	37	13	32721512	32721512	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr13:32721512G>T	uc001utx.2	+	12	1769	c.1273G>T	c.(1273-1275)GCT>TCT	p.A425S	FRY_uc010tdw.1_RNA	NM_023037	NP_075463	Q5TBA9	FRY_HUMAN	furry homolog	425					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane				ovary(5)|large_intestine(1)|skin(1)	7		Lung SC(185;0.0271)		all cancers(112;4.81e-05)|Epithelial(112;0.000656)|OV - Ovarian serous cystadenocarcinoma(117;0.0123)|BRCA - Breast invasive adenocarcinoma(63;0.0295)|GBM - Glioblastoma multiforme(144;0.104)		AAGCAACACAGCTACTCAGAG	0.398			NA											10	21					7.48243e-07	1.66062e-05	0.000442599	1	0
DCLK1	9201	broad.mit.edu	37	13	36445427	36445427	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr13:36445427G>C	uc001uvf.2	-	5	1107	c.874C>G	c.(874-876)CGC>GGC	p.R292G	uc001uvi.1_Intron	NM_004734	NP_004725	O15075	DCLK1_HUMAN	doublecortin-like kinase 1	292	Pro/Ser-rich.				cell differentiation|central nervous system development|endosome transport|intracellular signal transduction|response to virus	integral to plasma membrane	ATP binding|protein serine/threonine kinase activity|receptor signaling protein activity			stomach(6)|ovary(2)|skin(1)	9		Breast(139;0.0147)|Lung SC(185;0.0685)|Prostate(109;0.122)	KIRC - Kidney renal clear cell carcinoma(5;0.119)|Kidney(79;0.169)	all cancers(112;1.72e-06)|Epithelial(112;4.24e-05)|BRCA - Breast invasive adenocarcinoma(63;0.00159)|OV - Ovarian serous cystadenocarcinoma(117;0.0158)|GBM - Glioblastoma multiforme(144;0.0638)		GTGCTCCTGCGGGATGATGAA	0.507			NA											6	192					0	0	8.12818e-05	0	0
POSTN	10631	broad.mit.edu	37	13	38153365	38153365	+	Splice_Site	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr13:38153365C>G	uc001uwo.3	-	13	1909	c.1791_splice	c.e13+1	p.E597_splice	POSTN_uc010tet.1_Splice_Site_p.E125_splice|POSTN_uc001uwp.3_Splice_Site_p.E597_splice|POSTN_uc001uwr.2_Splice_Site_p.E597_splice|POSTN_uc001uwq.2_Splice_Site_p.E597_splice|POSTN_uc010teu.1_Splice_Site_p.E597_splice|POSTN_uc010tev.1_Splice_Site_p.E597_splice|POSTN_uc010tew.1_Splice_Site_p.E597_splice	NM_006475	NP_006466	Q15063	POSTN_HUMAN	periostin, osteoblast specific factor isoform 1						cell adhesion|skeletal system development	proteinaceous extracellular matrix	heparin binding			ovary(2)	2		Lung NSC(96;2.09e-05)|Prostate(109;0.0513)|Breast(139;0.0538)|Lung SC(185;0.0743)		all cancers(112;2.48e-08)|Epithelial(112;2.78e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000853)|BRCA - Breast invasive adenocarcinoma(63;0.013)|GBM - Glioblastoma multiforme(144;0.0154)		AGACAACTTACTTCTTTCAGA	0.318			NA											43	44					0	0	0.000125731	0	0
ZC3H13	23091	broad.mit.edu	37	13	46559733	46559733	+	Silent	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr13:46559733G>T	uc010tfw.1	-	9	1425	c.1419C>A	c.(1417-1419)TCC>TCA	p.S473S	ZC3H13_uc001vas.1_Silent_p.S473S|ZC3H13_uc001vat.1_Silent_p.S473S	NM_015070	NP_055885	Q5T200	ZC3HD_HUMAN	zinc finger CCCH-type containing 13	473	Arg/Ser-rich.						nucleic acid binding|zinc ion binding			ovary(1)|lung(1)	2		Lung NSC(96;7.26e-05)|Breast(56;0.000118)|Prostate(109;0.00217)|Hepatocellular(98;0.0207)|Lung SC(185;0.0262)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;4.18e-05)		GCATGTCTCTGGAGTCTCTTA	0.517	Esophageal Squamous(187;747 2077 11056 31291 44172)		NA											8	179					0.000157383	0.00327129	0.000157383	1	0
LRCH1	23143	broad.mit.edu	37	13	47315857	47315859	+	Missense_Mutation	TNP	CGG	CGG	ATT			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CGG	CGG	-	-	CGG	CGG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr13:47315857_47315859CGG>ATT	uc001vbj.2	+	19	2297_2299	c.2061_2063CGG>ATT	c.(2059-2064)CTCGGG>CTATTG	p.G688L	LRCH1_uc001vbk.2_Missense_Mutation_p.G723L|LRCH1_uc001vbl.3_Intron	NM_015116	NP_055931	Q9Y2L9	LRCH1_HUMAN	leucine-rich repeats and calponin homology (CH)	688	CH.									ovary(1)|central_nervous_system(1)	2		all_lung(13;5.61e-07)|Lung NSC(96;0.000117)|Breast(56;0.000141)|Prostate(109;0.0029)|Lung SC(185;0.0367)|Myeloproliferative disorder(33;0.0505)|Hepatocellular(98;0.0556)	KIRC - Kidney renal clear cell carcinoma(16;0.234)	GBM - Glioblastoma multiforme(144;0.000123)		TGCTGGCACTCGGGGAGAAAGCC	0.512			NA											10	401					0	0	6.4e-05	0	0
ATP7B	540	broad.mit.edu	37	13	52548699	52548699	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr13:52548699C>G	uc001vfw.2	-	2	814	c.657G>C	c.(655-657)CTG>CTC	p.L219L	ATP7B_uc010adv.2_Silent_p.L219L|ATP7B_uc001vfx.2_Silent_p.L219L|ATP7B_uc001vfy.2_Silent_p.L219L|ATP7B_uc010tgt.1_Silent_p.L219L|ATP7B_uc010tgu.1_Silent_p.L219L|ATP7B_uc010tgv.1_Silent_p.L219L|ATP7B_uc010tgw.1_Silent_p.L187L	NM_000053	NP_000044	P35670	ATP7B_HUMAN	ATPase, Cu++ transporting, beta polypeptide	219	Cytoplasmic (Potential).				ATP biosynthetic process|cellular copper ion homeostasis|copper ion import|response to copper ion|sequestering of calcium ion	Golgi membrane|integral to plasma membrane|late endosome|mitochondrion	ATP binding|copper ion binding|copper-exporting ATPase activity|protein binding			ovary(1)|central_nervous_system(1)|skin(1)	3		Breast(56;0.000207)|Lung NSC(96;0.000845)|Prostate(109;0.0235)|Hepatocellular(98;0.065)|all_neural(104;0.19)		GBM - Glioblastoma multiforme(99;5.25e-08)		CAATTGGTCCCAGGCTTAAGG	0.448			NA							Wilson_disease				6	219					0	0	3.59834e-05	0	0
NEK5	341676	broad.mit.edu	37	13	52676385	52676385	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr13:52676385T>A	uc001vge.2	-	10	793	c.653A>T	c.(652-654)CAA>CTA	p.Q218L	NEK5_uc001vgf.2_Missense_Mutation_p.Q218L	NM_199289	NP_954983	Q6P3R8	NEK5_HUMAN	NIMA-related kinase 5	218	Protein kinase.						ATP binding|metal ion binding|protein serine/threonine kinase activity			upper_aerodigestive_tract(1)	1		Breast(56;0.00173)|Lung NSC(96;0.0168)|Prostate(109;0.0412)|Hepatocellular(98;0.152)|Glioma(44;0.236)		GBM - Glioblastoma multiforme(99;3.7e-08)		AAAATGTGCTTGACAAATCTT	0.408			NA											85	159					0	0	0.000147903	0	0
VPS36	51028	broad.mit.edu	37	13	53008930	53008931	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr13:53008930_53008931GG>TT	uc001vgs.2	-	5	472_473	c.438_439CC>AA	c.(436-441)CCCCAG>CCAAAG	p.Q147K	VPS36_uc001vgq.2_Missense_Mutation_p.Q89K	NM_016075	NP_057159	Q86VN1	VPS36_HUMAN	vacuolar protein sorting 36	147					cellular membrane organization|endosome transport|protein transport|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|late endosome|membrane|nucleus	lipid binding			skin(1)	1		Breast(56;0.000207)|Lung NSC(96;0.00212)|Hepatocellular(98;0.065)|Prostate(109;0.0771)|all_neural(104;0.173)		GBM - Glioblastoma multiforme(99;3.14e-08)		AAAAATACCTGGGGTCCTCTAT	0.351			NA											10	331					0	0	6.4e-05	0	0
KLHL1	57626	broad.mit.edu	37	13	70314593	70314593	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr13:70314593G>T	uc001vip.2	-	8	2529	c.1735C>A	c.(1735-1737)CAA>AAA	p.Q579K	KLHL1_uc010thm.1_Missense_Mutation_p.Q518K	NM_020866	NP_065917	Q9NR64	KLHL1_HUMAN	kelch-like 1 protein	579	Kelch 3.				actin cytoskeleton organization	cytoplasm|cytoskeleton	actin binding				0		Breast(118;0.000162)		COAD - Colon adenocarcinoma(199;0.000193)|GBM - Glioblastoma multiforme(99;0.000211)		AATGTCCATTGTTGACTCTGT	0.408			NA											28	39					1.26454e-06	2.79295e-05	0.000117367	1	0
SLITRK6	84189	broad.mit.edu	37	13	86368421	86368421	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr13:86368421G>T	uc001vll.1	-	2	2682	c.2223C>A	c.(2221-2223)AAC>AAA	p.N741K	SLITRK6_uc010afe.1_Missense_Mutation_p.N194K	NM_032229	NP_115605	Q9H5Y7	SLIK6_HUMAN	slit and trk like 6 precursor	741	Cytoplasmic (Potential).					integral to membrane				large_intestine(1)|ovary(1)|central_nervous_system(1)	3	all_neural(89;0.117)|Medulloblastoma(90;0.163)			GBM - Glioblastoma multiforme(99;0.0456)		CTGTTGATTGGTTCGTGGTTT	0.373			NA											174	282					9.06622e-77	2.4318e-75	0.000147903	1	0
OXGR1	27199	broad.mit.edu	37	13	97639335	97639335	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr13:97639335G>C	uc001vmx.1	-	4	923	c.679C>G	c.(679-681)CAT>GAT	p.H227D	OXGR1_uc010afr.1_Missense_Mutation_p.H227D	NM_080818	NP_543008	Q96P68	OXGR1_HUMAN	oxoglutarate (alpha-ketoglutarate) receptor 1	227	Cytoplasmic (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)|skin(1)	2	all_neural(89;0.0982)|Medulloblastoma(90;0.163)		BRCA - Breast invasive adenocarcinoma(86;0.186)			TGCAGTCCATGGGTCAGAGTG	0.428			NA											5	69					0	0	1.23904e-05	0	0
IRS2	8660	broad.mit.edu	37	13	110437749	110437749	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr13:110437749G>C	uc001vqv.2	-	1	1166	c.652C>G	c.(652-654)CGT>GGT	p.R218G		NM_003749	NP_003740	Q9Y4H2	IRS2_HUMAN	insulin receptor substrate 2	218	IRS-type PTB.				fibroblast growth factor receptor signaling pathway|glucose metabolic process|insulin receptor signaling pathway|lipid homeostasis|negative regulation of B cell apoptosis|negative regulation of kinase activity|negative regulation of plasma membrane long-chain fatty acid transport|nerve growth factor receptor signaling pathway|phosphatidylinositol-mediated signaling|positive regulation of B cell proliferation|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin secretion|response to glucose stimulus	cytosol|plasma membrane	insulin receptor binding|signal transducer activity			large_intestine(2)|lung(2)|upper_aerodigestive_tract(1)|skin(1)|ovary(1)|kidney(1)	8	all_cancers(4;7.57e-15)|all_epithelial(4;5.91e-09)|all_lung(23;7.64e-07)|Lung NSC(43;0.000183)|Colorectal(4;0.00159)|all_neural(89;0.00294)|Medulloblastoma(90;0.00596)|Lung SC(71;0.0155)	Breast(118;0.159)	all cancers(43;0.00815)|BRCA - Breast invasive adenocarcinoma(86;0.11)|Epithelial(84;0.127)|GBM - Glioblastoma multiforme(44;0.147)			AGGCACAGACGGTACACCCCC	0.667	Melanoma(100;613 2409 40847)		NA											3	21					0	0	6.4e-05	0	0
OR4K2	390431	broad.mit.edu	37	14	20344567	20344567	+	Silent	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr14:20344567C>A	uc001vwh.1	+	1	141	c.141C>A	c.(139-141)ATC>ATA	p.I47I		NM_001005501	NP_001005501	Q8NGD2	OR4K2_HUMAN	olfactory receptor, family 4, subfamily K,	47	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)|skin(2)	4	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TCATAGTCATCACAGTTATAG	0.423			NA											107	183					5.4258e-56	1.44408e-54	0.000147903	1	0
SLC39A2	29986	broad.mit.edu	37	14	21467712	21467712	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr14:21467712C>A	uc001vyr.2	+	1	294	c.107C>A	c.(106-108)GCA>GAA	p.A36E	SLC39A2_uc001vys.2_5'UTR	NM_014579	NP_055394	Q9NP94	S39A2_HUMAN	solute carrier family 39 (zinc transporter),	36	Cytoplasmic (Potential).					cytoplasmic membrane-bounded vesicle|integral to plasma membrane	zinc ion transmembrane transporter activity			ovary(2)|central_nervous_system(1)	3	all_cancers(95;0.00267)		OV - Ovarian serous cystadenocarcinoma(11;1.34e-10)|Epithelial(56;1.57e-08)|all cancers(55;7.45e-08)	GBM - Glioblastoma multiforme(265;0.0187)		CAGATTGATGCAGCCAGAGGT	0.507			NA											28	17					4.43304e-23	1.11719e-21	0.000147802	1	0
HECTD1	25831	broad.mit.edu	37	14	31604225	31604225	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr14:31604225C>G	uc001wrc.1	-	22	3920	c.3431G>C	c.(3430-3432)TGG>TCG	p.W1144S	HECTD1_uc001wrd.1_Missense_Mutation_p.W659S	NM_015382	NP_056197	Q9ULT8	HECD1_HUMAN	HECT domain containing 1	1144					protein ubiquitination involved in ubiquitin-dependent protein catabolic process	intracellular	metal ion binding|protein binding|ubiquitin-protein ligase activity			ovary(3)|large_intestine(1)|lung(1)	5	Hepatocellular(127;0.0877)|Breast(36;0.176)		LUAD - Lung adenocarcinoma(48;0.00292)|Lung(238;0.0164)|BRCA - Breast invasive adenocarcinoma(188;0.111)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.00617)		TGGTATCACCCAGAGACCCAG	0.428			NA											5	98					0	0	3.59834e-05	0	0
GPHN	10243	broad.mit.edu	37	14	67589024	67589024	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr14:67589024C>T	uc001xiy.2	+	16	2700	c.1579C>T	c.(1579-1581)CGT>TGT	p.R527C	GPHN_uc001xix.2_Missense_Mutation_p.R560C|GPHN_uc010tss.1_Missense_Mutation_p.R573C|GPHN_uc010tst.1_Missense_Mutation_p.R496C|GPHN_uc010tsu.1_Missense_Mutation_p.R450C	NM_001024218	NP_001019389	Q9NQX3	GEPH_HUMAN	gephyrin isoform 2	527	MPT adenylyltransferase.				Mo-molybdopterin cofactor biosynthetic process|water-soluble vitamin metabolic process	cell junction|cytoplasm|cytoskeleton|postsynaptic membrane	ATP binding|metal ion binding|nucleotidyltransferase activity			ovary(2)	2		all_cancers(7;0.0476)|all_hematologic(31;0.0116)		Epithelial(1;1.73e-08)|all cancers(60;3.15e-07)|OV - Ovarian serous cystadenocarcinoma(108;0.000275)|BRCA - Breast invasive adenocarcinoma(234;0.00323)|Colorectal(3;0.0938)|KIRC - Kidney renal clear cell carcinoma(182;0.184)		AGACAGCAATCGTTCAACTCT	0.388			NA	T	MLL	AL								29	16					0	0	0.000339439	0	0
SLC8A3	6547	broad.mit.edu	37	14	70633596	70633596	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr14:70633596G>T	uc001xly.2	-	2	2298	c.1544C>A	c.(1543-1545)TCC>TAC	p.S515Y	SLC8A3_uc001xlw.2_Missense_Mutation_p.S515Y|SLC8A3_uc001xlx.2_Missense_Mutation_p.S515Y|SLC8A3_uc001xlz.2_Missense_Mutation_p.S515Y|SLC8A3_uc010ara.2_RNA	NM_183002	NP_892114	P57103	NAC3_HUMAN	solute carrier family 8 (sodium/calcium	515	Cytoplasmic (Potential).				cell communication|platelet activation	integral to membrane|plasma membrane	calcium:sodium antiporter activity|calmodulin binding			skin(3)|ovary(2)|breast(2)	7				BRCA - Breast invasive adenocarcinoma(234;0.0079)|all cancers(60;0.0102)|OV - Ovarian serous cystadenocarcinoma(108;0.0555)		CACACAAGGGGAGGCTAGGAC	0.498			NA											21	13					1.96292e-10	4.49415e-09	0.000175454	1	0
EIF2B2	8892	broad.mit.edu	37	14	75475847	75475847	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr14:75475847C>G	uc001xrc.1	+	8	1094	c.1012C>G	c.(1012-1014)CGC>GGC	p.R338G		NM_014239	NP_055054	P49770	EI2BB_HUMAN	eukaryotic translation initiation factor 2B,	338					cellular response to stimulus|myelination|oligodendrocyte development|ovarian follicle development|regulation of translational initiation|response to glucose stimulus|response to heat|response to peptide hormone stimulus	cytosol|eukaryotic translation initiation factor 2B complex	ATP binding|GTP binding|protein binding|translation initiation factor activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(234;0.00661)		CTACATCTACCGCCTGATGAG	0.483			NA											5	142					0	0	1.23904e-05	0	0
NDN	4692	broad.mit.edu	37	15	23931903	23931903	+	Silent	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr15:23931903G>A	uc001ywk.2	-	1	548	c.462C>T	c.(460-462)CAC>CAT	p.H154H		NM_002487	NP_002478	Q99608	NECD_HUMAN	necdin	154	MAGE.				negative regulation of cell proliferation|regulation of growth|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perikaryon	DNA binding				0		all_cancers(20;1.78e-24)|all_epithelial(15;7.75e-22)|Lung NSC(15;2.96e-18)|all_lung(15;2.8e-17)|Breast(32;0.000625)|Colorectal(260;0.14)		all cancers(64;8.37e-11)|Epithelial(43;9.29e-10)|BRCA - Breast invasive adenocarcinoma(123;0.00179)|GBM - Glioblastoma multiforme(186;0.018)|Lung(196;0.153)		TTAGCCTCAGGTGCAGCCCGA	0.617			NA							Prader-Willsyndrome				27	30					0	0	9.22233e-05	0	0
C15orf2	23742	broad.mit.edu	37	15	24921131	24921131	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr15:24921131C>A	uc001ywo.2	+	1	591	c.117C>A	c.(115-117)CAC>CAA	p.H39Q		NM_018958	NP_061831	Q9NZP6	CO002_HUMAN	hypothetical protein LOC23742	39					cell differentiation|multicellular organismal development|spermatogenesis					ovary(2)|large_intestine(2)|skin(2)|kidney(1)|central_nervous_system(1)	8		all_cancers(20;2.14e-21)|all_epithelial(15;4.77e-19)|Lung NSC(15;1.43e-14)|all_lung(15;9.57e-14)|Breast(32;0.00086)		all cancers(64;3.19e-24)|Epithelial(43;2.67e-17)|GBM - Glioblastoma multiforme(186;7.36e-07)|BRCA - Breast invasive adenocarcinoma(123;0.000273)|Lung(196;0.229)		GTCGGGCTCACTCTGTACCCA	0.736			NA											12	19					1.61879e-10	3.71863e-09	0.00010058	1	0
FMN1	342184	broad.mit.edu	37	15	33191088	33191088	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr15:33191088C>G	uc001zhf.3	-	11	2992	c.2992G>C	c.(2992-2994)GGG>CGG	p.G998R		NM_001103184	NP_001096654	Q68DA7	FMN1_HUMAN	formin 1	1221	FH2.				actin cytoskeleton organization	actin cytoskeleton|adherens junction|cytoplasm|nucleus	actin binding			ovary(1)	1		all_lung(180;1.14e-07)		all cancers(64;3.05e-15)|Epithelial(43;1.67e-10)|GBM - Glioblastoma multiforme(186;4.95e-05)|BRCA - Breast invasive adenocarcinoma(123;0.0262)		AGATTAATCCCATTATCCTAG	0.358			NA											5	122					0	0	3.59834e-05	0	0
TMEM87A	25963	broad.mit.edu	37	15	42531877	42531878	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr15:42531877_42531878GG>TT	uc010udd.1	-	8	833_834	c.674_675CC>AA	c.(673-675)CCC>CAA	p.P225Q	TMEM87A_uc001zpf.3_Missense_Mutation_p.P164Q|TMEM87A_uc010bcu.1_Missense_Mutation_p.P164Q	NM_015497	NP_056312	Q8NBN3	TM87A_HUMAN	transmembrane protein 87A isoform 1	225						integral to membrane				ovary(1)	1		all_cancers(109;4.28e-16)|all_epithelial(112;1.04e-14)|Lung NSC(122;5.01e-09)|all_lung(180;2.24e-08)|Melanoma(134;0.0574)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;1.03e-06)		CAATCATCAAGGGATAGTCTTC	0.356			NA											10	219					0	0	6.4e-05	0	0
PDIA3	2923	broad.mit.edu	37	15	44061820	44061820	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr15:44061820C>G	uc001zsu.2	+	10	1390	c.1242C>G	c.(1240-1242)CCC>CCG	p.P414P	PDIA3_uc010bdp.2_Silent_p.P394P|PDIA3_uc010ued.1_Silent_p.P188P	NM_005313	NP_005304	P30101	PDIA3_HUMAN	protein disulfide-isomerase A3 precursor	414	Thioredoxin 2.				cell redox homeostasis|glycerol ether metabolic process|post-translational protein modification|protein folding|protein import into nucleus|protein N-linked glycosylation via asparagine|protein retention in ER lumen|signal transduction	endoplasmic reticulum lumen|melanosome	cysteine-type endopeptidase activity|electron carrier activity|phospholipase C activity|protein binding|protein disulfide isomerase activity|protein disulfide oxidoreductase activity			ovary(1)|skin(1)	2		all_cancers(109;2.61e-15)|all_epithelial(112;1.12e-12)|Lung NSC(122;2.17e-08)|all_lung(180;2.45e-07)|Melanoma(134;0.027)|Colorectal(260;0.215)		GBM - Glioblastoma multiforme(94;9.48e-07)		ACCTGGAGCCCAAGTATAAAG	0.388			NA											5	124					0	0	1.23904e-05	0	0
DUOXA2	405753	broad.mit.edu	37	15	45408801	45408801	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr15:45408801C>A	uc001zuo.2	+	4	708	c.428C>A	c.(427-429)GCG>GAG	p.A143E	DUOX2_uc010bea.2_5'Flank|DUOX2_uc001zun.2_5'Flank|DUOXA2_uc010beb.2_RNA	NM_207581	NP_997464	Q1HG44	DOXA2_HUMAN	dual oxidase activator 2	143	Extracellular (Potential).				protein transport	endoplasmic reticulum membrane|integral to membrane					0		all_cancers(109;5.7e-11)|all_epithelial(112;4.65e-09)|Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;2.88e-18)|GBM - Glioblastoma multiforme(94;3.95e-07)|COAD - Colon adenocarcinoma(120;0.0652)|Colorectal(133;0.0659)		GCGGAGTACGCGAACGCACTG	0.607			NA											15	29					1.49906e-05	0.000324325	0.000219431	1	0
VPS13C	54832	broad.mit.edu	37	15	62146670	62146671	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr15:62146670_62146671GG>TT	uc002agz.2	-	85	11321_11322	c.11247_11248CC>AA	c.(11245-11250)CCCCAA>CCAAAA	p.Q3750K	VPS13C_uc002aha.2_Missense_Mutation_p.Q3707K	NM_020821	NP_065872	Q709C8	VP13C_HUMAN	vacuolar protein sorting 13C protein isoform 2A	3750					protein localization					ovary(2)	2						GATGGCAATTGGGGTCTGAGAA	0.421			NA											12	255					0	0	6.4e-05	0	0
PARP6	56965	broad.mit.edu	37	15	72549734	72549734	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr15:72549734C>G	uc002auc.2	-	12	1413	c.954G>C	c.(952-954)CTG>CTC	p.L318L	PARP6_uc002aua.2_Silent_p.L163L|PARP6_uc002aub.2_RNA|PARP6_uc002aud.3_RNA|PARP6_uc002auf.1_Silent_p.L318L	NM_020214	NP_064599	Q2NL67	PARP6_HUMAN	poly (ADP-ribose) polymerase family, member 6	318							NAD+ ADP-ribosyltransferase activity				0						ACATGACGCCCAGTGTGTAGA	0.512			NA											5	146					0	0	8.12818e-05	0	0
SCAMP2	10066	broad.mit.edu	37	15	75137815	75137815	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr15:75137815C>G	uc002azb.1	-	8	928	c.854G>C	c.(853-855)CGG>CCG	p.R285P	ULK3_uc010ulp.1_5'Flank|ULK3_uc010ulq.1_5'Flank|ULK3_uc010ulr.1_5'Flank|ULK3_uc010bkf.1_5'Flank|ULK3_uc002ayv.2_5'Flank|ULK3_uc010uls.1_5'Flank|ULK3_uc010ult.1_5'Flank|ULK3_uc010ulu.1_5'Flank|SCAMP2_uc002aza.1_Missense_Mutation_p.R135P|SCAMP2_uc010bkg.1_RNA	NM_005697	NP_005688	O15127	SCAM2_HUMAN	secretory carrier membrane protein 2	285	Cytoplasmic (Potential).				post-Golgi vesicle-mediated transport|protein transport	integral to membrane|nucleus|recycling endosome membrane|trans-Golgi network membrane	protein binding			ovary(1)	1						ACCACTCACCCGCTGCAGGAG	0.562			NA											4	69					0	0	1.23904e-05	0	0
KIAA1024	23251	broad.mit.edu	37	15	79750551	79750551	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr15:79750551G>C	uc002bew.1	+	2	2137	c.2062G>C	c.(2062-2064)GGG>CGG	p.G688R	KIAA1024_uc010unk.1_Missense_Mutation_p.G688R	NM_015206	NP_056021	Q9UPX6	K1024_HUMAN	hypothetical protein LOC23251	688						integral to membrane				pancreas(2)|ovary(1)|central_nervous_system(1)	4						TGATGCTAGCGGGAGCAACAG	0.557			NA											4	124					0	0	1.23904e-05	0	0
HOMER2	9455	broad.mit.edu	37	15	83544130	83544130	+	Silent	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr15:83544130C>T	uc002bjg.2	-	3	375	c.189G>A	c.(187-189)CCG>CCA	p.P63P	HOMER2_uc002bjh.2_Silent_p.P63P|HOMER2_uc002bjj.2_Silent_p.P63P|HOMER2_uc002bji.2_Silent_p.P63P	NM_199330	NP_955362	Q9NSB8	HOME2_HUMAN	homer 2 isoform 2	63	WH1.				metabotropic glutamate receptor signaling pathway	cell junction|cytoplasm|postsynaptic density|postsynaptic membrane					0						AGGTCATATTCGGTGTGATTG	0.438			NA											24	36					0	0	0.00047179	0	0
AGBL1	123624	broad.mit.edu	37	15	87066060	87066061	+	Missense_Mutation	DNP	GG	GG	TC			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr15:87066060_87066061GG>TC	uc002blz.1	+	18	2517_2518	c.2437_2438GG>TC	c.(2437-2439)GGG>TCG	p.G813S		NM_152336	NP_689549	Q96MI9	CBPC4_HUMAN	ATP/GTP binding protein-like 1	813					C-terminal protein deglutamylation|protein side chain deglutamylation|proteolysis	cytosol	metallocarboxypeptidase activity|tubulin binding|zinc ion binding				0						CTCACTGAGCGGGGAAGATTTG	0.431			NA											7	92					0	0	6.4e-05	0	0
SLCO3A1	28232	broad.mit.edu	37	15	92669306	92669306	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr15:92669306C>G	uc002bqx.2	+	6	1391	c.1190C>G	c.(1189-1191)CCG>CGG	p.P397R	SLCO3A1_uc002bqy.2_Missense_Mutation_p.P397R|SLCO3A1_uc010boc.1_RNA|SLCO3A1_uc002bqz.1_Missense_Mutation_p.P339R	NM_013272	NP_037404	Q9UIG8	SO3A1_HUMAN	solute carrier organic anion transporter family,	397	Helical; Name=8; (Potential).				sodium-independent organic anion transport	integral to membrane|plasma membrane	sodium-independent organic anion transmembrane transporter activity			skin(1)	1	Lung NSC(78;0.0158)|all_lung(78;0.0255)		BRCA - Breast invasive adenocarcinoma(143;0.0841)			ACTGCGATCCCGTGTGCTTGT	0.602			NA											3	48					0	0	3.59834e-05	0	0
LRRC28	123355	broad.mit.edu	37	15	99926275	99926275	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr15:99926275C>G	uc002bva.1	+	10	1227	c.1072C>G	c.(1072-1074)CAG>GAG	p.Q358E	LRRC28_uc002bvb.1_Missense_Mutation_p.Q204E|LRRC28_uc010urt.1_Missense_Mutation_p.Q172E|LRRC28_uc002bvc.1_Silent_p.P304P|LRRC28_uc010uru.1_Missense_Mutation_p.Q289E|LRRC28_uc002bvd.1_Missense_Mutation_p.Q84E	NM_144598	NP_653199	Q86X40	LRC28_HUMAN	leucine rich repeat containing 28	358											0	Lung NSC(78;0.00175)|all_lung(78;0.00351)|Melanoma(26;0.00778)|Medulloblastoma(229;0.163)		OV - Ovarian serous cystadenocarcinoma(32;0.00106)			CTGCTCCACCCAGTGTCTGCA	0.493			NA											7	568					0	0	0.000157383	0	0
TARSL2	123283	broad.mit.edu	37	15	102264433	102264433	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr15:102264433T>A	uc002bxm.2	-	1	213	c.158A>T	c.(157-159)GAG>GTG	p.E53V	TARSL2_uc010usi.1_RNA	NM_152334	NP_689547	A2RTX5	SYTC2_HUMAN	threonyl-tRNA synthetase-like 2	53					threonyl-tRNA aminoacylation	cytoplasm	ATP binding|threonine-tRNA ligase activity			ovary(2)	2	Lung NSC(78;0.000991)|all_lung(78;0.00128)|Melanoma(26;0.00505)		OV - Ovarian serous cystadenocarcinoma(32;0.000268)|LUSC - Lung squamous cell carcinoma(107;0.187)|Lung(145;0.23)			CTGCGCCACCTCCCGCGTGAG	0.736			NA											5	4					0	0	1.23904e-05	0	0
MGRN1	23295	broad.mit.edu	37	16	4700385	4700385	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr16:4700385C>G	uc002cwz.2	+	2	244	c.108C>G	c.(106-108)CAC>CAG	p.H36Q	MGRN1_uc002cxa.2_Missense_Mutation_p.H36Q|MGRN1_uc010btx.2_Missense_Mutation_p.H36Q|MGRN1_uc010btw.2_Missense_Mutation_p.H36Q|MGRN1_uc002cxb.2_Missense_Mutation_p.H36Q|MGRN1_uc010uxo.1_Missense_Mutation_p.H36Q|MGRN1_uc010uxp.1_Missense_Mutation_p.H36Q|MGRN1_uc010uxq.1_RNA	NM_001142290	NP_001135762	O60291	MGRN1_HUMAN	mahogunin, ring finger 1 isoform 3	36					endosome to lysosome transport|negative regulation of cAMP-mediated signaling|negative regulation of G-protein coupled receptor protein signaling pathway|protein monoubiquitination	cytosol|early endosome|nucleus|plasma membrane|plasma membrane	protein binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)|skin(1)	2						TTGCTTCGCACTTTTTCATGG	0.358			NA											44	21					0	0	0.000147903	0	0
CIITA	4261	broad.mit.edu	37	16	11002979	11002979	+	Silent	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr16:11002979C>T	uc002dai.3	+	12	2884	c.2751C>T	c.(2749-2751)ATC>ATT	p.I917I	CIITA_uc002daj.3_Silent_p.I918I|CIITA_uc002dak.3_Silent_p.I333I|CIITA_uc010bup.1_Intron	NM_000246	NP_000237	P33076	C2TA_HUMAN	class II transactivator	917					interferon-gamma-mediated signaling pathway|negative regulation of transcription from RNA polymerase II promoter|positive regulation of MHC class I biosynthetic process|positive regulation of transcription from RNA polymerase II promoter|response to antibiotic|transcription, DNA-dependent	nucleus	activating transcription factor binding|ATP binding|protein C-terminus binding|protein complex binding|transcription coactivator activity|transcription regulatory region DNA binding			central_nervous_system(1)	1						AGTTCACCATCGAGCCTTTCA	0.592			NA	T	FLJ27352|CD274|CD273|RALGDS|RUNDC2A|C16orf75	PMBL|Hodgkin Lymphona|								20	13					0	0	0.000175454	0	0
GP2	2813	broad.mit.edu	37	16	20329730	20329730	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr16:20329730C>G	uc002dgv.2	-	8	1122	c.1039G>C	c.(1039-1041)GGG>CGG	p.G347R	GP2_uc002dgw.2_Missense_Mutation_p.G344R|GP2_uc002dgx.2_Missense_Mutation_p.G200R|GP2_uc002dgy.2_Missense_Mutation_p.G197R	NM_001007240	NP_001007241	P55259	GP2_HUMAN	zymogen granule membrane glycoprotein 2 isoform	347	ZP.					anchored to membrane|extracellular region|plasma membrane				ovary(3)|skin(1)	4						TCTCCATTCCCGTCCACACTG	0.468			NA											4	112					0	0	3.59834e-05	0	0
ACSM5	54988	broad.mit.edu	37	16	20429419	20429419	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr16:20429419C>G	uc002dhe.2	+	3	390	c.243C>G	c.(241-243)GTC>GTG	p.V81V	ACSM5_uc002dhd.1_Silent_p.V81V	NM_017888	NP_060358	Q6NUN0	ACSM5_HUMAN	acyl-CoA synthetase medium-chain family member 5	81					fatty acid metabolic process	mitochondrial matrix	ATP binding|butyrate-CoA ligase activity|GTP binding|metal ion binding			ovary(2)	2						TCTGGTGGGTCAATGGCACAG	0.532			NA											12	16					0	0	0.00010058	0	0
PRKCB	5579	broad.mit.edu	37	16	24196864	24196864	+	Silent	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr16:24196864G>A	uc002dmd.2	+	15	1895	c.1698G>A	c.(1696-1698)AAG>AAA	p.K566K	PRKCB_uc002dme.2_Silent_p.K566K	NM_212535	NP_997700	P05771	KPCB_HUMAN	protein kinase C, beta isoform 1	566	Protein kinase.				apoptosis|B cell activation|B cell receptor signaling pathway|intracellular signal transduction|lipoprotein transport|platelet activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|synaptic transmission|transcription, DNA-dependent	cytosol|nucleus|plasma membrane	androgen receptor binding|ATP binding|chromatin binding|histone binding|histone kinase activity (H3-T6 specific)|ligand-dependent nuclear receptor transcription coactivator activity|protein kinase C activity|protein kinase C binding|zinc ion binding			ovary(3)|central_nervous_system(3)|lung(2)|large_intestine(1)	9					Vitamin E(DB00163)	CTATGTCCAAGGAAGCTGTGG	0.373			NA											32	19					0	0	0.000159656	0	0
KIAA0556	23247	broad.mit.edu	37	16	27751862	27751862	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr16:27751862C>G	uc002dow.2	+	15	2268	c.2244C>G	c.(2242-2244)CCC>CCG	p.P748P		NM_015202	NP_056017	O60303	K0556_HUMAN	hypothetical protein LOC23247	748										ovary(4)|large_intestine(2)|upper_aerodigestive_tract(1)|skin(1)	8						GTGAGCCACCCGGGAAAACCC	0.577			NA											4	58					0	0	1.23904e-05	0	0
CD2BP2	10421	broad.mit.edu	37	16	30365255	30365255	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr16:30365255C>A	uc002dxr.2	-	3	595	c.342G>T	c.(340-342)CAG>CAT	p.Q114H	CD2BP2_uc002dxs.2_Missense_Mutation_p.Q114H	NM_006110	NP_006101	O95400	CD2B2_HUMAN	CD2 antigen (cytoplasmic tail) binding protein	114					assembly of spliceosomal tri-snRNP	cytoplasm|nucleoplasm|U5 snRNP	protein binding|ribonucleoprotein binding			ovary(1)	1						TGTCTCGGATCTGAGCATCCC	0.632			NA											82	29					1.30681e-28	3.37368e-27	0.000147903	1	0
CD2BP2	10421	broad.mit.edu	37	16	30365934	30365935	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr16:30365934_30365935GG>TT	uc002dxr.2	-	1	321_322	c.68_69CC>AA	c.(67-69)CCC>CAA	p.P23Q	CD2BP2_uc002dxs.2_Missense_Mutation_p.P23Q	NM_006110	NP_006101	O95400	CD2B2_HUMAN	CD2 antigen (cytoplasmic tail) binding protein	23					assembly of spliceosomal tri-snRNP	cytoplasm|nucleoplasm|U5 snRNP	protein binding|ribonucleoprotein binding			ovary(1)	1						CCTTCTTCTTGGGGACAATGAT	0.569			NA											25	776					0	0	6.4e-05	0	0
ITGAL	3683	broad.mit.edu	37	16	30507469	30507469	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr16:30507469G>C	uc002dyi.3	+	14	1731	c.1555G>C	c.(1555-1557)GGG>CGG	p.G519R	ITGAL_uc002dyj.3_Missense_Mutation_p.G436R|ITGAL_uc010vev.1_Intron	NM_002209	NP_002200	P20701	ITAL_HUMAN	integrin alpha L isoform a precursor	519	FG-GAP 6.|Extracellular (Potential).				blood coagulation|heterophilic cell-cell adhesion|inflammatory response|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response|T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell	integrin complex	cell adhesion molecule binding|receptor activity			ovary(3)|lung(3)|central_nervous_system(3)|breast(1)	10					Efalizumab(DB00095)	CTACCCACTCGGGCGGTTTGG	0.597	NSCLC(110;1462 1641 3311 33990 49495)		NA											5	236					0	0	1.23904e-05	0	0
SRCAP	10847	broad.mit.edu	37	16	30732600	30732600	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr16:30732600G>T	uc002dze.1	+	21	3729	c.3344G>T	c.(3343-3345)CGC>CTC	p.R1115L	SRCAP_uc002dzf.2_Intron|SRCAP_uc002dzg.1_Missense_Mutation_p.R972L|SRCAP_uc010bzz.1_Missense_Mutation_p.R685L	NM_006662	NP_006653	Q6ZRS2	SRCAP_HUMAN	Snf2-related CBP activator protein	1115	Pro-rich.				interspecies interaction between organisms|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|nucleus|protein complex	ATP binding|DNA binding|helicase activity|histone acetyltransferase activity|transcription coactivator activity			ovary(3)|skin(1)	4			Colorectal(24;0.198)			GCCCCAGTTCGCCTGAGCCCA	0.642			NA											139	102					1.9326e-39	5.08461e-38	0.000147903	1	0
TGFB1I1	7041	broad.mit.edu	37	16	31485199	31485199	+	Missense_Mutation	SNP	G	G	T	rs149961993	byFrequency	TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr16:31485199G>T	uc002ecd.1	+	4	252	c.226G>T	c.(226-228)GCC>TCC	p.A76S	TGFB1I1_uc002ece.1_Missense_Mutation_p.A59S|TGFB1I1_uc010caq.1_5'UTR	NM_001042454	NP_001035919	O43294	TGFI1_HUMAN	transforming growth factor beta 1 induced	76	Transcription activation (By similarity).|Interaction with PTK2B.				androgen receptor signaling pathway|cell adhesion|negative regulation of cell proliferation|negative regulation of transforming growth factor beta receptor signaling pathway|positive regulation of epithelial to mesenchymal transition|positive regulation of transcription, DNA-dependent|positive regulation of transforming growth factor beta receptor signaling pathway|transcription from RNA polymerase II promoter|ubiquitin-dependent SMAD protein catabolic process|Wnt receptor signaling pathway	cytoplasm|cytoskeleton|focal adhesion|nuclear matrix	androgen receptor binding|I-SMAD binding|Roundabout binding|transcription coactivator activity|zinc ion binding				0						AGCCCCGGCGGCCCCTCCATT	0.602			NA											46	65					1.81118e-26	4.62372e-25	0.000147903	1	0
NOD2	64127	broad.mit.edu	37	16	50733803	50733803	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr16:50733803G>A	uc002egm.1	+	2	583	c.478G>A	c.(478-480)GGT>AGT	p.G160S	NOD2_uc010cbj.1_Missense_Mutation_p.G133S|NOD2_uc010cbk.1_Missense_Mutation_p.G133S|NOD2_uc002egl.1_5'UTR	NM_022162	NP_071445	Q9HC29	NOD2_HUMAN	nucleotide-binding oligomerization domain	160	CARD 2.				activation of MAPK activity involved in innate immune response|cytokine production involved in immune response|detection of bacterium|detection of muramyl dipeptide|JNK cascade|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of macrophage apoptosis|nucleotide-binding oligomerization domain containing 2 signaling pathway|positive regulation of B cell activation|positive regulation of dendritic cell antigen processing and presentation|positive regulation of epithelial cell proliferation|positive regulation of ERK1 and ERK2 cascade|positive regulation of gamma-delta T cell activation|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-1 beta secretion|positive regulation of interleukin-10 production|positive regulation of interleukin-17 production|positive regulation of interleukin-6 production|positive regulation of JNK cascade|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of Notch signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity|positive regulation of prostaglandin-E synthase activity|positive regulation of prostaglandin-endoperoxide synthase activity|positive regulation of stress-activated MAPK cascade|positive regulation of tumor necrosis factor production|positive regulation of type 2 immune response|protein oligomerization|stress-activated MAPK cascade|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	cell surface|cytosol|plasma membrane|vesicle	ATP binding|CARD domain binding|muramyl dipeptide binding|protein kinase binding			ovary(3)|skin(1)	4		all_cancers(37;0.0156)				ATGGGAGCGGGGTTTCGTCAG	0.587			NA											14	33					0	0	5.01169e-05	0	0
POLR2C	5432	broad.mit.edu	37	16	57504902	57504902	+	Silent	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr16:57504902G>T	uc002elt.1	+	9	785	c.699G>T	c.(697-699)GTG>GTT	p.V233V		NM_032940	NP_116558	P19387	RPB3_HUMAN	DNA directed RNA polymerase II polypeptide C	233					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|protein dimerization activity				0						ACTACAATGTGGAGTCCTGTG	0.532			NA											7	116					0.000274275	0.00558288	0.000274275	1	0
RRAD	6236	broad.mit.edu	37	16	66957790	66957790	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr16:66957790C>G	uc002eqn.2	-	3	555	c.403G>C	c.(403-405)GGA>CGA	p.G135R	RRAD_uc002eqo.2_Missense_Mutation_p.G135R	NM_001128850	NP_001122322	P55042	RAD_HUMAN	Ras-related associated with diabetes	135					small GTPase mediated signal transduction	plasma membrane	calmodulin binding|GTP binding|GTPase activity				0		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0862)|Epithelial(162;0.198)		GCCTCTTCTCCGTCCACTACA	0.562			NA											4	151					0	0	1.23904e-05	0	0
KCTD19	146212	broad.mit.edu	37	16	67333438	67333438	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr16:67333438C>G	uc002esu.2	-	6	865	c.814G>C	c.(814-816)GGG>CGG	p.G272R	KCTD19_uc002est.2_Missense_Mutation_p.G44R|KCTD19_uc010vjj.1_Missense_Mutation_p.G15R	NM_001100915	NP_001094385	Q17RG1	KCD19_HUMAN	potassium channel tetramerisation domain	272						voltage-gated potassium channel complex	voltage-gated potassium channel activity			skin(1)	1		Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.0311)|Epithelial(162;0.0906)		GCCCCCTTCCCGGGGCTCAGG	0.637			NA											4	94					0	0	0.00024832	0	0
RANBP10	57610	broad.mit.edu	37	16	67805983	67805983	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr16:67805983C>G	uc002eud.2	-	3	470	c.354G>C	c.(352-354)ATG>ATC	p.M118I	RANBP10_uc010ceo.2_5'UTR|RANBP10_uc010vju.1_Missense_Mutation_p.M118I|RANBP10_uc010vjv.1_Missense_Mutation_p.M1I|RANBP10_uc010vjx.1_Missense_Mutation_p.M118I|RANBP10_uc010vjy.1_Intron	NM_020850	NP_065901	Q6VN20	RBP10_HUMAN	RAN binding protein 10	118	B30.2/SPRY.									ovary(1)	1		Acute lymphoblastic leukemia(13;4.34e-06)|all_hematologic(13;0.000643)|Ovarian(137;0.192)		OV - Ovarian serous cystadenocarcinoma(108;0.00522)|Epithelial(162;0.025)|all cancers(182;0.157)		GTCCTATTCCCATGTAACTTC	0.373			NA											6	205					0	0	3.59834e-05	0	0
TMCO7	79613	broad.mit.edu	37	16	68912103	68912103	+	Nonsense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr16:68912103C>G	uc002ewi.3	+	6	1226	c.1214C>G	c.(1213-1215)TCA>TGA	p.S405*		NM_024562	NP_078838	Q9C0B7	TMCO7_HUMAN	transmembrane and coiled-coil domains 7	405						integral to membrane	binding				0		Ovarian(137;0.0568)		OV - Ovarian serous cystadenocarcinoma(108;0.0446)|Epithelial(162;0.198)		ATAACTTTGTCAAGAGAACGC	0.408			NA											28	49					0	0	0.000339439	0	0
PDPR	55066	broad.mit.edu	37	16	70180115	70180115	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr16:70180115C>A	uc002eyf.1	+	16	2903	c.1946C>A	c.(1945-1947)CCA>CAA	p.P649Q	CLEC18C_uc002exy.2_Intron|PDPR_uc010vlr.1_Missense_Mutation_p.P549Q|PDPR_uc002eyg.1_Missense_Mutation_p.P377Q|PDPR_uc002eyh.2_5'UTR|PDPR_uc010vls.1_5'UTR	NM_017990	NP_060460	Q8NCN5	PDPR_HUMAN	pyruvate dehydrogenase phosphatase regulatory	649					glycine catabolic process|pyruvate metabolic process|regulation of acetyl-CoA biosynthetic process from pyruvate	mitochondrial matrix	aminomethyltransferase activity|oxidoreductase activity			breast(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.124)		GACCACTTCCCAAGCCTCTTT	0.453			NA											10	266					3.27435e-08	7.37399e-07	0.000219431	1	0
AARS	16	broad.mit.edu	37	16	70305819	70305819	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr16:70305819C>T	uc002eyn.1	-	5	646	c.536G>A	c.(535-537)GGT>GAT	p.G179D	AARS_uc010vlu.1_Missense_Mutation_p.G9D	NM_001605	NP_001596	P49588	SYAC_HUMAN	alanyl-tRNA synthetase	179					alanyl-tRNA aminoacylation|tRNA processing	cytosol|soluble fraction	alanine-tRNA ligase activity|ATP binding|metal ion binding|tRNA binding			pancreas(1)	1		Ovarian(137;0.0365)		BRCA - Breast invasive adenocarcinoma(221;0.161)	L-Alanine(DB00160)	GCCCGTGTCACCCATCTCCCA	0.542			NA											29	53					0	0	0.000279167	0	0
SF3B3	23450	broad.mit.edu	37	16	70563080	70563080	+	Silent	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr16:70563080C>A	uc002ezf.2	+	3	586	c.375C>A	c.(373-375)CCC>CCA	p.P125P	SNORD111B_uc010cfv.1_5'Flank	NM_012426	NP_036558	Q15393	SF3B3_HUMAN	splicing factor 3b, subunit 3	125					protein complex assembly	catalytic step 2 spliceosome|nucleoplasm|small nuclear ribonucleoprotein complex|U12-type spliceosomal complex	nucleic acid binding|protein binding			ovary(1)	1		Ovarian(137;0.0694)				CTGTGGATCCCAAAGGGCGAG	0.463			NA											7	55					6.31663e-08	1.41328e-06	0.000308642	1	0
HYDIN	54768	broad.mit.edu	37	16	70954583	70954583	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr16:70954583C>A	uc002ezr.2	-	46	7821	c.7693G>T	c.(7693-7695)GTA>TTA	p.V2565L		NM_032821	NP_116210	Q4G0P3	HYDIN_HUMAN	hydrocephalus inducing isoform a	2566										ovary(1)|skin(1)	2		Ovarian(137;0.0654)				AGGAAGGGTACGCCCAGGtcc	0.299			NA											10	22					2.17888e-05	0.000469192	0.000442599	1	0
DHX38	9785	broad.mit.edu	37	16	72142724	72142725	+	Missense_Mutation	DNP	GC	GC	TT			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr16:72142724_72142725GC>TT	uc002fcb.2	+	24	3636_3637	c.3281_3282GC>TT	c.(3280-3282)CGC>CTT	p.R1094L	DHX38_uc010vmp.1_Missense_Mutation_p.R406L	NM_014003	NP_054722	Q92620	PRP16_HUMAN	DEAH (Asp-Glu-Ala-His) box polypeptide 38	1094					mRNA 3'-end processing|mRNA export from nucleus|nuclear mRNA splicing, via spliceosome|termination of RNA polymerase II transcription	catalytic step 2 spliceosome|nucleoplasm	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			skin(1)	1		Ovarian(137;0.125)				GTGAACATCCGCACAGGGATGC	0.55	Melanoma(97;711 1442 7855 13832 28836)		NA											10	24					0	0	6.4e-05	0	0
GAN	8139	broad.mit.edu	37	16	81388139	81388139	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr16:81388139C>G	uc002fgo.2	+	3	560	c.412C>G	c.(412-414)CGT>GGT	p.R138G		NM_022041	NP_071324	Q9H2C0	GAN_HUMAN	gigaxonin	138	BACK.		R -> H (in GAN).		cell death	cytoplasm|neurofilament	protein binding			ovary(2)	2		Colorectal(91;0.153)				TATTGGTATCCGTGACTTTGC	0.483	GBM(106;1239 1507 7582 9741 33976)		NA											4	186					0	0	0.00024832	0	0
CDH13	1012	broad.mit.edu	37	16	83781757	83781757	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr16:83781757C>G	uc002fgx.2	+	11	1703	c.1583C>G	c.(1582-1584)CCC>CGC	p.P528R	CDH13_uc010vns.1_Missense_Mutation_p.P575R|CDH13_uc010vnt.1_Missense_Mutation_p.P274R|CDH13_uc010vnu.1_Missense_Mutation_p.P489R	NM_001257	NP_001248	P55290	CAD13_HUMAN	cadherin 13 preproprotein	528	Cadherin 4.				adherens junction organization|calcium-dependent cell-cell adhesion|cell junction assembly|endothelial cell migration|homophilic cell adhesion|keratinocyte proliferation|lamellipodium assembly|localization within membrane|low-density lipoprotein particle mediated signaling|negative regulation of cell adhesion|negative regulation of cell proliferation|positive regulation of calcium-mediated signaling|positive regulation of cell migration|positive regulation of cell-matrix adhesion|positive regulation of endothelial cell proliferation|positive regulation of positive chemotaxis|positive regulation of smooth muscle cell proliferation|positive regulation of survival gene product expression|Rac protein signal transduction|regulation of endocytosis|regulation of epidermal growth factor receptor signaling pathway|Rho protein signal transduction|sprouting angiogenesis	anchored to membrane|caveola|extracellular space|integral to membrane|neuron projection	adiponectin binding|cadherin binding|calcium ion binding|low-density lipoprotein particle binding			large_intestine(1)	1		all_cancers(2;1.34e-11)|all_epithelial(2;4.3e-09)		COAD - Colon adenocarcinoma(5;0.0268)		AATATTAACCCCATCAATGGG	0.463			NA											5	213					0	0	3.59834e-05	0	0
ZNF276	92822	broad.mit.edu	37	16	89788983	89788983	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr16:89788983G>C	uc002fos.3	+	2	347	c.250G>C	c.(250-252)GGG>CGG	p.G84R	C16orf7_uc002fol.1_5'Flank|C16orf7_uc002fom.1_5'Flank|ZNF276_uc010ciq.2_5'UTR|ZNF276_uc002fop.2_Missense_Mutation_p.G9R|ZNF276_uc002foq.3_Missense_Mutation_p.G9R|ZNF276_uc010cir.2_RNA|ZNF276_uc002for.3_5'UTR|ZNF276_uc010cis.2_5'UTR|ZNF276_uc002fot.3_RNA|ZNF276_uc010vpm.1_5'Flank|ZNF276_uc010cit.1_5'Flank	NM_001113525	NP_001106997	Q8N554	ZN276_HUMAN	zinc finger protein 276 isoform a	84	ZAD.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0		Lung NSC(15;2.19e-05)|all_lung(18;3.07e-05)|all_hematologic(23;0.0256)		BRCA - Breast invasive adenocarcinoma(80;0.0278)		CCTCTGCCACGGGAAGTTTTC	0.647			NA											4	70					0	0	0.00024832	0	0
DNAH9	1770	broad.mit.edu	37	17	11572723	11572723	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr17:11572723C>T	uc002gne.2	+	17	3033	c.2965C>T	c.(2965-2967)CGG>TGG	p.R989W	DNAH9_uc010coo.2_Missense_Mutation_p.R283W	NM_001372	NP_001363	Q9NYC9	DYH9_HUMAN	dynein, axonemal, heavy chain 9 isoform 2	989	Stem (By similarity).				cell projection organization|cellular component movement|microtubule-based movement|spermatogenesis	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			skin(10)|ovary(4)|breast(3)|central_nervous_system(2)|pancreas(1)	20		Breast(5;0.0122)|all_epithelial(5;0.131)		Colorectal(4;6.88e-05)|COAD - Colon adenocarcinoma(4;0.000813)|READ - Rectum adenocarcinoma(10;0.157)		GGCAAACATGCGGCGCACACT	0.557			NA											13	9					0	0	0.000151284	0	0
LGALS9	3965	broad.mit.edu	37	17	25969281	25969281	+	Silent	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr17:25969281C>A	uc002gzp.2	+	4	469	c.351C>A	c.(349-351)ATC>ATA	p.I117I	LGALS9_uc002gzq.2_Silent_p.I117I|LGALS9_uc002gzr.2_Silent_p.I60I|LGALS9_uc010waa.1_Silent_p.I60I|LGALS9_uc002gzs.2_Silent_p.I117I	NM_009587	NP_033665	O00182	LEG9_HUMAN	galectin-9 isoform long	117	Galectin 1.				positive regulation of I-kappaB kinase/NF-kappaB cascade	cytoplasm|extracellular region	galactose binding|signal transducer activity				0	Lung NSC(42;0.0103)		BRCA - Breast invasive adenocarcinoma(3;0.0141)	UCEC - Uterine corpus endometrioid carcinoma (53;0.155)		TGAACGGGATCCTCTTCGTGC	0.597	Melanoma(106;677 1527 28724 29571 46552)|Ovarian(193;263 2088 2118 29005 43023)		NA											17	10					4.43304e-23	1.11719e-21	0.000147802	1	0
SUPT6H	6830	broad.mit.edu	37	17	27014204	27014204	+	Silent	SNP	C	C	A	rs145262815		TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr17:27014204C>A	uc002hby.2	+	22	2889	c.2799C>A	c.(2797-2799)TCC>TCA	p.S933S	SUPT6H_uc010crt.2_Silent_p.S933S|SUPT6H_uc002hbz.1_5'Flank	NM_003170	NP_003161	Q7KZ85	SPT6H_HUMAN	suppressor of Ty 6 homolog	933					chromatin remodeling|regulation of transcription elongation, DNA-dependent|regulation of transcription from RNA polymerase II promoter	nucleus	hydrolase activity, acting on ester bonds|RNA binding|sequence-specific DNA binding transcription factor activity			ovary(2)|skin(1)	3	Lung NSC(42;0.00431)					TGTGCAGTTCCGATGAAGACA	0.562			NA											6	150					0.000157383	0.00327129	0.000157383	1	0
NUFIP2	57532	broad.mit.edu	37	17	27613442	27613442	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr17:27613442C>A	uc002hdy.3	-	2	1659	c.1570G>T	c.(1570-1572)GGG>TGG	p.G524W	NUFIP2_uc002hdx.3_Intron	NM_020772	NP_065823	Q7Z417	NUFP2_HUMAN	nuclear fragile X mental retardation protein	524						nucleus|polysomal ribosome	protein binding|RNA binding			skin(2)|ovary(1)|breast(1)	4			BRCA - Breast invasive adenocarcinoma(11;0.000457)|Colorectal(6;0.0178)|COAD - Colon adenocarcinoma(6;0.0551)			GATGACTTCCCAGTAACAGTC	0.458			NA											6	84					8.12818e-05	0.00171015	8.12818e-05	1	0
TCAP	8557	broad.mit.edu	37	17	37821714	37821714	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr17:37821714C>G	uc002hsh.2	+	1	116	c.102C>G	c.(100-102)CCC>CCG	p.P34P	PNMT_uc002hsi.1_5'Flank	NM_003673	NP_003664	O15273	TELT_HUMAN	telethonin	34					adult heart development|cardiac muscle contraction|cardiac muscle fiber development|cardiac muscle tissue morphogenesis|detection of mechanical stimulus|muscle filament sliding|response to stress|sarcomere organization|skeletal muscle contraction|skeletal muscle myosin thick filament assembly|skeletal muscle thin filament assembly	cytosol|Z disc	structural constituent of muscle|titin binding|titin Z domain binding				0	all_cancers(6;6.59e-85)|all_epithelial(6;2.89e-103)|Breast(7;1.05e-86)|Lung NSC(9;1.15e-09)|all_lung(9;6.24e-09)|Colorectal(19;0.000442)|Esophageal squamous(10;0.052)		UCEC - Uterine corpus endometrioid carcinoma (11;0.000126)|BRCA - Breast invasive adenocarcinoma(8;3.87e-45)|Lung(15;0.00193)|LUAD - Lung adenocarcinoma(14;0.0664)|LUSC - Lung squamous cell carcinoma(15;0.171)			CCACACGGCCCGAGGAGGGGT	0.617			NA											3	29					0	0	6.4e-05	0	0
THRA	7067	broad.mit.edu	37	17	38244622	38244622	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr17:38244622G>C	uc002htw.2	+	8	1334	c.851G>C	c.(850-852)CGG>CCG	p.R284P	THRA_uc010cwp.1_Missense_Mutation_p.R284P|THRA_uc002htv.2_Missense_Mutation_p.R284P|THRA_uc002htx.2_Missense_Mutation_p.R284P	NM_003250	NP_003241	P10827	THA_HUMAN	thyroid hormone receptor, alpha isoform 2	284	Ligand-binding.				negative regulation of RNA polymerase II transcriptional preinitiation complex assembly|negative regulation of transcription initiation, DNA-dependent|regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor|transcription from RNA polymerase II promoter	cytosol|nucleoplasm	protein domain specific binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|steroid hormone receptor activity|TBP-class protein binding|thyroid hormone binding|thyroid hormone receptor activity|transcription regulatory region DNA binding|zinc ion binding				0	Colorectal(19;0.000442)	Myeloproliferative disorder(1115;0.0255)			Levothyroxine(DB00451)|Liothyronine(DB00279)	GCTGTCAAGCGGGAGCAGCTC	0.607			NA											4	48					0	0	0.00024832	0	0
G6PC	2538	broad.mit.edu	37	17	41052971	41052971	+	Silent	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr17:41052971C>T	uc002icb.1	+	1	157	c.78C>T	c.(76-78)TCC>TCT	p.S26S	LOC388387_uc002ibz.2_5'Flank|LOC388387_uc002iby.2_5'Flank|LOC388387_uc002ica.2_5'Flank|LOC388387_uc010whe.1_5'Flank|G6PC_uc010whf.1_Silent_p.S28S	NM_000151	NP_000142	P35575	G6PC_HUMAN	glucose-6-phosphatase, catalytic subunit	26	Lumenal (Potential).				gluconeogenesis|glucose homeostasis|transmembrane transport	integral to endoplasmic reticulum membrane	glucose-6-phosphatase activity|phosphate binding			ovary(1)|breast(1)|kidney(1)|skin(1)	4		Breast(137;0.000143)		BRCA - Breast invasive adenocarcinoma(366;0.113)		ACCAAGACTCCCAGGACTGGT	0.502			NA							Glycogen_Storage_Disease_type_Ia				43	28					0	0	0.000374591	0	0
NAGS	162417	broad.mit.edu	37	17	42082136	42082136	+	Silent	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr17:42082136G>A	uc002ies.2	+	1	105	c.105G>A	c.(103-105)GCG>GCA	p.A35A	PYY_uc002ieq.2_5'Flank|NAGS_uc010czn.2_Silent_p.A35A|NAGS_uc002iet.2_5'Flank	NM_153006	NP_694551	Q8N159	NAGS_HUMAN	N-acetylglutamate synthase	35					arginine biosynthetic process|urea cycle	mitochondrial matrix	acetyl-CoA:L-glutamate N-acetyltransferase activity				0		Breast(137;0.00536)|Prostate(33;0.0724)		BRCA - Breast invasive adenocarcinoma(366;0.113)	L-Glutamic Acid(DB00142)	GCTGTggcgcgcggcggcggg	0.572			NA											6	6					0	0	3.59834e-05	0	0
ZNF652	22834	broad.mit.edu	37	17	47390144	47390144	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr17:47390144G>C	uc002iov.3	-	3	1428	c.964C>G	c.(964-966)CAT>GAT	p.H322D	ZNF652_uc002iow.2_Missense_Mutation_p.H322D|ZNF652_uc002iou.3_RNA	NM_001145365	NP_001138837	Q9Y2D9	ZN652_HUMAN	zinc finger protein 652	322	C2H2-type 3.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(1)	1	all_cancers(4;6.81e-14)|Breast(4;4.97e-29)|all_epithelial(4;1.53e-17)		BRCA - Breast invasive adenocarcinoma(1;3.1e-14)|Epithelial(5;2.92e-06)|all cancers(6;3.15e-05)			GCATATCCATGGACGATCTTG	0.368			NA											4	66					0	0	1.23904e-05	0	0
GRB2	2885	broad.mit.edu	37	17	73316467	73316467	+	Silent	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr17:73316467G>C	uc002jnx.3	-	6	993	c.636C>G	c.(634-636)CCC>CCG	p.P212P	GRB2_uc002jny.3_Silent_p.P171P	NM_002086	NP_002077	P62993	GRB2_HUMAN	growth factor receptor-bound protein 2 isoform	212	SH3 2.				axon guidance|blood coagulation|cell junction assembly|cell-cell signaling|cellular response to ionizing radiation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|interspecies interaction between organisms|leukocyte migration|negative regulation of epidermal growth factor receptor signaling pathway|nerve growth factor receptor signaling pathway|positive regulation of reactive oxygen species metabolic process|Ras protein signal transduction|receptor internalization|signal transduction in response to DNA damage|T cell costimulation	cytosol|Golgi apparatus	epidermal growth factor receptor binding|insulin receptor substrate binding|SH3/SH2 adaptor activity			ovary(3)	3	all_cancers(13;5.44e-09)|all_epithelial(9;1.1e-09)|Breast(9;1.85e-09)|all_lung(278;0.222)		all cancers(21;1.09e-07)|Epithelial(20;1.23e-06)|Lung(188;0.185)		Pegademase bovine(DB00061)	TCCGGTTCACGGGGGTGACAT	0.453			NA											5	216					0	0	3.59834e-05	0	0
UBE2O	63893	broad.mit.edu	37	17	74392594	74392594	+	Silent	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr17:74392594G>C	uc002jrm.3	-	14	2489	c.2424C>G	c.(2422-2424)CCC>CCG	p.P808P	UBE2O_uc002jrn.3_Silent_p.P808P|UBE2O_uc002jrl.3_Silent_p.P412P	NM_022066	NP_071349	Q9C0C9	UBE2O_HUMAN	ubiquitin-conjugating enzyme E2O	808							ATP binding|ubiquitin-protein ligase activity			breast(2)|skin(2)|lung(1)	5						GGAAGCTCTTGGGTGGCCCGT	0.632			NA											5	145					0	0	8.12818e-05	0	0
CBX8	57332	broad.mit.edu	37	17	77768512	77768512	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr17:77768512C>G	uc002jxd.1	-	5	1185	c.1092G>C	c.(1090-1092)ACG>ACC	p.T364T		NM_020649	NP_065700	Q9HC52	CBX8_HUMAN	chromobox homolog 8	364					negative regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nuclear chromatin|PcG protein complex	methylated histone residue binding				0			OV - Ovarian serous cystadenocarcinoma(97;0.0102)|BRCA - Breast invasive adenocarcinoma(99;0.0224)			AGGTCACGTCCGTGACCACCA	0.547			NA											4	127					0	0	1.23904e-05	0	0
C17orf90	339229	broad.mit.edu	37	17	79632502	79632502	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr17:79632502C>G	uc002kba.2	-	2	184	c.173G>C	c.(172-174)GGG>GCG	p.G58A	C17orf90_uc002kbb.2_3'UTR|CCDC137_uc002kbc.3_5'Flank|CCDC137_uc002kbd.2_5'Flank	NM_001039842	NP_001034931	Q5BKU9	CQ090_HUMAN	hypothetical protein LOC339229	58											0	all_neural(118;0.0878)|all_lung(278;0.23)|Melanoma(429;0.242)		BRCA - Breast invasive adenocarcinoma(99;0.0101)|OV - Ovarian serous cystadenocarcinoma(97;0.0739)			GTGGTCTGTCCCGAATTTTCT	0.647			NA											3	22					0	0	6.4e-05	0	0
TXNDC2	84203	broad.mit.edu	37	18	9886894	9886894	+	Missense_Mutation	SNP	A	A	G	rs146821851		TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr18:9886894A>G	uc002koi.3	+	2	867	c.418A>G	c.(418-420)AAA>GAA	p.K140E	TXNDC2_uc010wzq.1_RNA|TXNDC2_uc002koh.3_Missense_Mutation_p.K73E	NM_001098529	NP_001091999	Q86VQ3	TXND2_HUMAN	thioredoxin domain-containing 2 isoform 2	140	2.|22 X 15 AA approximate tandem repeat of Q-P-K-X-G-D-I-P-K-S-[PS]-E-[KE]-X-I.				cell differentiation|cell redox homeostasis|glycerol ether metabolic process|multicellular organismal development|spermatogenesis	cytoplasm	electron carrier activity|nutrient reservoir activity|protein disulfide oxidoreductase activity|thioredoxin-disulfide reductase activity			ovary(1)|pancreas(1)	2						GTCCTCAGAAAAAGCCATCCA	0.547			NA											4	59					0	0	1.23904e-05	0	0
MC5R	4161	broad.mit.edu	37	18	13826264	13826264	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr18:13826264G>C	uc010xaf.1	+	1	500	c.500G>C	c.(499-501)TGG>TCG	p.W167S		NM_005913	NP_005904	P33032	MC5R_HUMAN	melanocortin 5 receptor	167	Helical; Name=4; (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			ovary(3)|lung(2)|breast(1)	6						GCCGGCATCTGGGCTTTCTGC	0.572			NA											6	300					0	0	8.12818e-05	0	0
MC5R	4161	broad.mit.edu	37	18	13826433	13826433	+	Silent	SNP	C	C	G	rs142471410		TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr18:13826433C>G	uc010xaf.1	+	1	669	c.669C>G	c.(667-669)CCC>CCG	p.P223P		NM_005913	NP_005904	P33032	MC5R_HUMAN	melanocortin 5 receptor	223	Cytoplasmic (Potential).			ALPGASSARQRTSM -> LCPGPALRGRGPAW (in Ref. 1).	G-protein signaling, coupled to cyclic nucleotide second messenger|positive regulation of cAMP biosynthetic process	integral to plasma membrane	melanocortin receptor activity|protein binding			ovary(3)|lung(2)|breast(1)	6						CGGCTCTGCCCGGGGCCAGCT	0.622			NA											5	182					0	0	1.23904e-05	0	0
HRH4	59340	broad.mit.edu	37	18	22048811	22048811	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr18:22048811G>T	uc002kvi.2	+	2	353	c.253G>T	c.(253-255)GAA>TAA	p.E85*	HRH4_uc010xbd.1_Intron|HRH4_uc010dlx.2_Intron	NM_021624	NP_067637	Q9H3N8	HRH4_HUMAN	histamine H4 receptor isoform 1	85	Extracellular (Potential).					integral to membrane|plasma membrane	histamine receptor activity			ovary(2)	2	all_cancers(21;0.000545)|all_epithelial(16;6.56e-06)|Lung NSC(20;0.0027)|all_lung(20;0.0085)|Colorectal(14;0.0361)|Ovarian(20;0.0991)				Clozapine(DB00363)	TTTTGGAAAGGAAATCTGTGT	0.408			NA											29	75					1.13719e-10	2.61668e-09	0.000227799	1	0
ZNF521	25925	broad.mit.edu	37	18	22805988	22805988	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr18:22805988C>G	uc002kvk.2	-	4	2141	c.1894G>C	c.(1894-1896)GGA>CGA	p.G632R	ZNF521_uc010xbe.1_RNA|ZNF521_uc010dly.2_Missense_Mutation_p.G632R|ZNF521_uc002kvl.2_Missense_Mutation_p.G412R	NM_015461	NP_056276	Q96K83	ZN521_HUMAN	zinc finger protein 521	632					cell differentiation|multicellular organismal development|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein domain specific binding|zinc ion binding			ovary(4)|large_intestine(2)|lung(1)	7	all_cancers(21;0.0025)|all_epithelial(16;3.62e-05)|Ovarian(20;0.0991)					ATATATTCTCCAGTGGGACGT	0.473			NA	T	PAX5	ALL								7	556					0	0	0.000274275	0	0
ASXL3	80816	broad.mit.edu	37	18	31319522	31319522	+	Silent	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr18:31319522G>A	uc010dmg.1	+	11	2209	c.2154G>A	c.(2152-2154)CCG>CCA	p.P718P	ASXL3_uc002kxq.2_Silent_p.P425P	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	718	Ser-rich.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						AAACCTCACCGATGTCTGACT	0.403			NA											203	333					0	0	0.000147903	0	0
ASXL3	80816	broad.mit.edu	37	18	31325208	31325208	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr18:31325208C>A	uc010dmg.1	+	12	5451	c.5396C>A	c.(5395-5397)CCG>CAG	p.P1799Q	ASXL3_uc002kxq.2_Missense_Mutation_p.P1506Q	NM_030632	NP_085135	Q9C0F0	ASXL3_HUMAN	additional sex combs like 3	1799					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding			ovary(2)|pancreas(1)	3						GTTGAAATTCCGCCCAGCTCT	0.498			NA											44	59					4.01765e-15	9.548e-14	0.000437636	1	0
C18orf21	83608	broad.mit.edu	37	18	33554959	33554959	+	Silent	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr18:33554959C>A	uc002kzc.2	+	3	305	c.201C>A	c.(199-201)CCC>CCA	p.P67P	C18orf21_uc002kzd.2_5'UTR	NM_031446	NP_113634	Q32NC0	CR021_HUMAN	chromosome 18 open reading frame 21	67											0						GGTTGACACCCAAAATACAGA	0.393			NA											9	139					0.000442599	0.00887779	0.000442599	1	0
SYT4	6860	broad.mit.edu	37	18	40854018	40854018	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr18:40854018A>G	uc002law.2	-	2	745	c.376T>C	c.(376-378)TTT>CTT	p.F126L	SYT4_uc010dng.2_Intron|SYT4_uc010xcm.1_Missense_Mutation_p.F108L|SYT4_uc010dnh.2_Intron	NM_020783	NP_065834	Q9H2B2	SYT4_HUMAN	synaptotagmin IV	126	Cytoplasmic (Potential).					cell junction|integral to membrane|synaptic vesicle membrane	transporter activity			skin(5)	5						CCTTCTAAAAAGAGCTTCGGG	0.443	NSCLC(85;81 1419 2855 22820 35912)		NA											4	80					0	0	1.23904e-05	0	0
KIAA1632	57724	broad.mit.edu	37	18	43459085	43459085	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr18:43459085C>A	uc002lbm.2	-	33	5862	c.5762G>T	c.(5761-5763)AGT>ATT	p.S1921I	KIAA1632_uc010xcq.1_Missense_Mutation_p.S475I|KIAA1632_uc010xcr.1_RNA|KIAA1632_uc010xcs.1_RNA|KIAA1632_uc002lbn.2_Missense_Mutation_p.S796I	NM_020964	NP_066015	Q9HCE0	EPG5_HUMAN	hypothetical protein LOC57724	1921					autophagy						0						CATATAAGGACTCCATTTTGA	0.413			NA											50	98					4.78724e-31	1.24523e-29	0.000147903	1	0
RNF165	494470	broad.mit.edu	37	18	44030290	44030290	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr18:44030290C>G	uc002lcb.1	+	5	698	c.647C>G	c.(646-648)CCT>CGT	p.P216R	RNF165_uc002lby.1_Missense_Mutation_p.P149R|RNF165_uc010dnn.1_Missense_Mutation_p.P12R	NM_152470	NP_689683	Q6ZSG1	RN165_HUMAN	ring finger protein 165	216							zinc ion binding				0				READ - Rectum adenocarcinoma(1;0.0873)		TACCCTTACCCTCAGCTTCAC	0.512			NA											20	46					0	0	0.000295444	0	0
TCEB3C	162699	broad.mit.edu	37	18	44554643	44554643	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr18:44554643G>T	uc010xdb.1	-	1	1807	c.1571C>A	c.(1570-1572)GCT>GAT	p.A524D	KATNAL2_uc010dnq.1_Intron|KATNAL2_uc002lco.2_Intron|KATNAL2_uc002lcp.3_Intron	NM_145653	NP_663628	Q8NG57	ELOA3_HUMAN	transcription elongation factor B polypeptide	524					regulation of transcription, DNA-dependent|transcription, DNA-dependent	integral to membrane|nucleus	DNA binding				0						TTTCTTGGCAGCCTGTTTTCG	0.338			NA											19	385					1.55469e-16	3.75309e-15	0.00047179	1	0
CCDC11	220136	broad.mit.edu	37	18	47753912	47753912	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr18:47753912G>T	uc002lee.2	-	8	1475	c.1384C>A	c.(1384-1386)CAA>AAA	p.Q462K		NM_145020	NP_659457	Q96M91	CCD11_HUMAN	coiled-coil domain containing 11	462	Potential.									ovary(1)|pancreas(1)|skin(1)	3				STAD - Stomach adenocarcinoma(97;2.66e-05)|Colorectal(21;7.57e-05)|Lung(128;0.00932)|READ - Rectum adenocarcinoma(32;0.164)		TCTGCTTCTTGGGACTGCTGC	0.468			NA											13	355					7.07596e-05	0.00149793	7.07596e-05	1	0
ME2	4200	broad.mit.edu	37	18	48450553	48450553	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr18:48450553T>C	uc002ley.2	+	11	1398	c.1142T>C	c.(1141-1143)GTG>GCG	p.V381A	ME2_uc010dpd.2_Missense_Mutation_p.V381A	NM_002396	NP_002387	P23368	MAOM_HUMAN	malic enzyme 2, NAD(+)-dependent, mitochondrial	381					malate metabolic process	mitochondrial matrix	electron carrier activity|malate dehydrogenase (decarboxylating) activity|malate dehydrogenase (oxaloacetate-decarboxylating) activity|metal ion binding|NAD binding				0		Colorectal(6;0.0273)|all_epithelial(6;0.118)		Colorectal(21;0.0313)|READ - Rectum adenocarcinoma(32;0.105)|STAD - Stomach adenocarcinoma(97;0.184)	NADH(DB00157)	GAAGATGCAGTGAATATACTG	0.358			NA											24	63					0	0	0.000117367	0	0
DCC	1630	broad.mit.edu	37	18	50734108	50734108	+	Nonsense_Mutation	SNP	T	T	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr18:50734108T>A	uc002lfe.1	+	11	2369	c.1782T>A	c.(1780-1782)TAT>TAA	p.Y594*	DCC_uc010xdr.1_Nonsense_Mutation_p.Y442*|DCC_uc010dpf.1_Nonsense_Mutation_p.Y249*	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	594	Extracellular (Potential).|Fibronectin type-III 2.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		TCACCGAATATAGTCTTCGAT	0.378			NA											45	94					0	0	0.000125731	0	0
DCC	1630	broad.mit.edu	37	18	50734144	50734144	+	Silent	SNP	G	G	C	rs143737066	byFrequency	TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr18:50734144G>C	uc002lfe.1	+	11	2405	c.1818G>C	c.(1816-1818)CCG>CCC	p.P606P	DCC_uc010xdr.1_Silent_p.P454P|DCC_uc010dpf.1_Silent_p.P261P	NM_005215	NP_005206	P43146	DCC_HUMAN	netrin receptor DCC precursor	606	Extracellular (Potential).|Fibronectin type-III 2.				apoptosis|induction of apoptosis|negative regulation of collateral sprouting|negative regulation of dendrite development	cytosol|integral to membrane				skin(8)|ovary(6)|upper_aerodigestive_tract(1)|large_intestine(1)|central_nervous_system(1)	17		all_cancers(7;0.11)|all_epithelial(6;0.00126)		Colorectal(16;0.0251)|COAD - Colon adenocarcinoma(17;0.0942)		GCTATGGTCCGGGCGTCTCTA	0.353			NA											5	158					0	0	8.12818e-05	0	0
CBLN2	147381	broad.mit.edu	37	18	70209161	70209161	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr18:70209161T>A	uc002lku.2	-	2	470	c.235A>T	c.(235-237)ACC>TCC	p.T79S	CBLN2_uc002lkv.2_Missense_Mutation_p.T79S	NM_182511	NP_872317	Q8IUK8	CBLN2_HUMAN	cerebellin 2 precursor	79						integral to membrane					0		Esophageal squamous(42;0.131)				AGGGAGGAGGTGACGGCGCCG	0.706			NA											6	26					0	0	3.59834e-05	0	0
KCNG2	26251	broad.mit.edu	37	18	77659266	77659266	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr18:77659266G>A	uc010xfl.1	+	2	851	c.851G>A	c.(850-852)GGG>GAG	p.G284E		NM_012283	NP_036415	Q9UJ96	KCNG2_HUMAN	potassium voltage-gated channel, subfamily G,	284					energy reserve metabolic process|regulation of heart contraction|regulation of insulin secretion	voltage-gated potassium channel complex	delayed rectifier potassium channel activity				0		Esophageal squamous(42;0.0157)|Melanoma(33;0.144)		OV - Ovarian serous cystadenocarcinoma(15;6.92e-07)|BRCA - Breast invasive adenocarcinoma(31;0.0244)		GAGCGCGCGGGGCTGGTGCTG	0.716			NA											5	5					0	0	8.12818e-05	0	0
SAFB2	9667	broad.mit.edu	37	19	5621405	5621405	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr19:5621405C>G	uc002mcd.2	-	2	401	c.189G>C	c.(187-189)GCG>GCC	p.A63A	SAFB_uc010xiq.1_5'Flank|SAFB_uc002mcf.2_5'Flank|SAFB_uc002mcg.2_5'Flank|SAFB_uc002mce.3_5'Flank|SAFB_uc010xir.1_5'Flank|SAFB_uc010xis.1_5'Flank|SAFB_uc010xit.1_5'Flank|SAFB_uc010xiu.1_5'Flank|SAFB2_uc010xio.1_Silent_p.A63A|SAFB2_uc010xip.1_RNA	NM_014649	NP_055464	Q14151	SAFB2_HUMAN	scaffold attachment factor B2	63	SAP.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	DNA binding|nucleotide binding|protein binding|RNA binding				0				UCEC - Uterine corpus endometrioid carcinoma (162;0.000228)		CTTCTTTAACCGCCTATTAGG	0.443	Ovarian(127;888 1728 23957 44128 52668)		NA											5	119					0	0	1.23904e-05	0	0
MUC16	94025	broad.mit.edu	37	19	9065289	9065289	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr19:9065289A>G	uc002mkp.2	-	3	22361	c.22157T>C	c.(22156-22158)GTG>GCG	p.V7386A		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7388	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGTTTCTTCCACAGGGAGAGA	0.502			NA											14	9					0	0	0.000151284	0	0
MUC16	94025	broad.mit.edu	37	19	9065940	9065940	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr19:9065940G>T	uc002mkp.2	-	3	21710	c.21506C>A	c.(21505-21507)ACC>AAC	p.T7169N		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	7171	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TGTATTTGTGGTGTCCTTGCC	0.507			NA											48	29					2.9001e-28	7.45895e-27	0.000147903	1	0
MUC16	94025	broad.mit.edu	37	19	9084758	9084758	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr19:9084758C>A	uc002mkp.2	-	1	7261	c.7057G>T	c.(7057-7059)GAT>TAT	p.D2353Y		NM_024690	NP_078966	Q8WXI7	MUC16_HUMAN	mucin 16	2353	Ser-rich.|Thr-rich.|Extracellular (Potential).				cell adhesion	extracellular space|extrinsic to membrane|integral to membrane|plasma membrane	protein binding			lung(30)|ovary(15)|breast(8)|large_intestine(1)|skin(1)|prostate(1)|pancreas(1)	57						TCAAGGATATCTGAGGTTTTT	0.453			NA											21	11					1.64113e-05	0.000354506	0.000175454	1	0
OR7C1	26664	broad.mit.edu	37	19	14910187	14910187	+	Silent	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr19:14910187C>A	uc010xnz.1	-	1	762	c.762G>T	c.(760-762)ACG>ACT	p.T254T		NM_198944	NP_945182	O76099	OR7C1_HUMAN	olfactory receptor, family 7, subfamily C,	254	Helical; Name=6; (Potential).				sensory perception of smell|spermatogenesis	integral to membrane|plasma membrane	olfactory receptor activity			ovary(2)	2						CCCCAAAGCCCGTGCCATAGA	0.517			NA											30	7					8.88839e-20	2.19972e-18	0.000339439	1	0
OR7A5	26659	broad.mit.edu	37	19	14938679	14938679	+	Silent	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr19:14938679G>A	uc002mzw.2	-	1	598	c.375C>T	c.(373-375)GCC>GCT	p.A125A	OR7A5_uc010xoa.1_Silent_p.A125A	NM_017506	NP_059976	Q15622	OR7A5_HUMAN	olfactory receptor, family 7, subfamily A,	125	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			central_nervous_system(2)	2						GGTGACAGATGGCCACAAACC	0.488			NA											40	11					0	0	0.000106405	0	0
EPS15L1	58513	broad.mit.edu	37	19	16487937	16487937	+	Silent	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr19:16487937G>C	uc002ndz.1	-	22	2382	c.2376C>G	c.(2374-2376)CCC>CCG	p.P792P	EPS15L1_uc002ndx.2_Silent_p.P792P|EPS15L1_uc002ndy.2_Intron|EPS15L1_uc010xpe.1_Intron|EPS15L1_uc010xpf.1_Silent_p.P695P|EPS15L1_uc002nea.1_Intron|EPS15L1_uc010eah.1_Intron	NM_021235	NP_067058	Q9UBC2	EP15R_HUMAN	epidermal growth factor receptor pathway	792	Pro-rich.|15 X 3 AA repeats of D-P-F.				endocytosis|epidermal growth factor receptor signaling pathway|negative regulation of epidermal growth factor receptor signaling pathway	coated pit|nucleus|plasma membrane	calcium ion binding			ovary(3)|skin(2)	5						ACTGACCGCTGGGCGGTTTAG	0.607			NA									OREG0025332	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	4	43					0	0	1.23904e-05	0	0
ZNF737	100129842	broad.mit.edu	37	19	20727897	20727897	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr19:20727897C>A	uc002npa.2	-	4	1292	c.1112G>T	c.(1111-1113)TGT>TTT	p.C371F		NM_001159293	NP_001152765	C9JHM3	C9JHM3_HUMAN	zinc finger protein 737	371					regulation of transcription, DNA-dependent	intracellular	nucleic acid binding|zinc ion binding			ovary(1)	1						ACATTCTTCACATTTGTAGGG	0.408			NA											13	13					3.45872e-05	0.000742464	0.000422831	1	0
GPATCH1	55094	broad.mit.edu	37	19	33602681	33602681	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr19:33602681G>T	uc002nug.1	+	12	1951	c.1637G>T	c.(1636-1638)CGT>CTT	p.R546L	GPATCH1_uc002nuh.1_5'Flank	NM_018025	NP_060495	Q9BRR8	GPTC1_HUMAN	G patch domain containing 1	546						catalytic step 2 spliceosome	nucleic acid binding			skin(1)	1	Esophageal squamous(110;0.137)					GAGCGAGGCCGTGAGCGGGAT	0.582	Pancreas(67;88 1713 4567 18227)		NA											30	11					1.30897e-18	3.22208e-17	0.000279167	1	0
CATSPERG	57828	broad.mit.edu	37	19	38853033	38853033	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr19:38853033G>C	uc002oih.3	+	19	2262	c.2175G>C	c.(2173-2175)TTG>TTC	p.L725F	CATSPERG_uc002oig.3_Missense_Mutation_p.L685F|CATSPERG_uc002oif.3_Missense_Mutation_p.L365F|CATSPERG_uc010efw.2_RNA	NM_021185	NP_067008	Q6ZRH7	CTSRG_HUMAN	cation channel, sperm-associated, gamma	725	Extracellular (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	integral to membrane				ovary(1)|skin(1)	2						ACTTCTTCTTGGCGAGCAATT	0.642			NA											4	61					0	0	1.23904e-05	0	0
SPTBN4	57731	broad.mit.edu	37	19	41077931	41077931	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr19:41077931G>C	uc002ony.2	+	34	7412	c.7326G>C	c.(7324-7326)TGG>TGC	p.W2442C	SPTBN4_uc002onz.2_Missense_Mutation_p.W2442C|SPTBN4_uc010egx.2_Missense_Mutation_p.W1185C	NM_020971	NP_066022	Q9H254	SPTN4_HUMAN	spectrin, beta, non-erythrocytic 4 isoform	2442	PH.				actin filament capping|axon guidance|cytoskeletal anchoring at plasma membrane|vesicle-mediated transport	cytosol|nuclear matrix|PML body|spectrin	actin binding|ankyrin binding|structural constituent of cytoskeleton			ovary(3)|central_nervous_system(1)|skin(1)	5			Lung(22;0.000114)|LUSC - Lung squamous cell carcinoma(20;0.000384)			CCAGGTCGTGGGTGAGCCTGT	0.562			NA											6	191					0	0	0.000157383	0	0
PSG5	5673	broad.mit.edu	37	19	43689024	43689024	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr19:43689024G>C	uc002ovu.2	-	2	471	c.340C>G	c.(340-342)CGG>GGG	p.R114G	PSG6_uc010xwk.1_Intron|PSG5_uc010eir.2_Missense_Mutation_p.R42G|PSG5_uc002ovx.2_Missense_Mutation_p.R114G|PSG5_uc002ovv.2_Missense_Mutation_p.R114G|PSG5_uc002ovw.2_Missense_Mutation_p.R114G	NM_002781	NP_002772	Q15238	PSG5_HUMAN	pregnancy specific beta-1-glycoprotein 5	114	Ig-like V-type.				female pregnancy	extracellular region				skin(3)	3		Prostate(69;0.00899)				GCGTCTTCCCGGGTGACATTC	0.428			NA											6	260					0	0	3.59834e-05	0	0
LIG1	3978	broad.mit.edu	37	19	48631178	48631178	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr19:48631178G>C	uc002pia.1	-	20	2041	c.1921C>G	c.(1921-1923)CGC>GGC	p.R641G	LIG1_uc010xze.1_Missense_Mutation_p.R334G|LIG1_uc002phz.1_RNA|LIG1_uc002pib.1_RNA|LIG1_uc010xzf.1_Missense_Mutation_p.R573G|LIG1_uc010xzg.1_Missense_Mutation_p.R610G	NM_000234	NP_000225	P18858	DNLI1_HUMAN	DNA ligase I	641					anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			large_intestine(2)|lung(1)	3		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)	TTGCGTTTGCGGGTGGTGAGC	0.592			NA						NER					5	147					0	0	3.59834e-05	0	0
NCR1	9437	broad.mit.edu	37	19	55420752	55420752	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr19:55420752C>A	uc002qib.2	+	4	542	c.504C>A	c.(502-504)TAC>TAA	p.Y168*	NCR1_uc002qic.2_Nonsense_Mutation_p.Y168*|NCR1_uc002qie.2_Nonsense_Mutation_p.Y168*|NCR1_uc002qid.2_Nonsense_Mutation_p.Y73*|NCR1_uc002qif.2_Nonsense_Mutation_p.Y73*|NCR1_uc010esj.2_Nonsense_Mutation_p.Y61*	NM_004829	NP_004820	O76036	NCTR1_HUMAN	natural cytotoxicity triggering receptor 1	168	Extracellular (Potential).|Ig-like 2.				cellular defense response|natural killer cell activation|regulation of natural killer cell mediated cytotoxicity	integral to plasma membrane|SWI/SNF complex	receptor activity|receptor signaling protein activity			large_intestine(1)|ovary(1)	2				GBM - Glioblastoma multiforme(193;0.0449)		AGCGCGGATACGGGAAGGTCC	0.567			NA											18	22					4.96729e-08	1.11501e-06	0.000132079	1	0
NLRP4	147945	broad.mit.edu	37	19	56379135	56379135	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr19:56379135C>A	uc002qmd.3	+	6	2669	c.2247C>A	c.(2245-2247)AAC>AAA	p.N749K	NLRP4_uc002qmf.2_Missense_Mutation_p.N674K|NLRP4_uc010etf.2_Intron	NM_134444	NP_604393	Q96MN2	NALP4_HUMAN	NLR family, pyrin domain containing 4	749							ATP binding			ovary(5)|skin(4)|lung(3)|upper_aerodigestive_tract(1)|kidney(1)|pancreas(1)	15		Colorectal(82;0.0002)|Ovarian(87;0.221)		GBM - Glioblastoma multiforme(193;0.0606)		TTCTAACCAACAACAAGAAGC	0.488			NA											50	33					1.86633e-21	4.66075e-20	0.000147903	1	0
ZNF548	147694	broad.mit.edu	37	19	57908500	57908500	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr19:57908500C>G	uc002qom.2	+	2	350	c.100C>G	c.(100-102)CGT>GGT	p.R34G	ZNF547_uc002qpm.3_Intron|ZNF548_uc002qon.2_Missense_Mutation_p.R37G	NM_152909	NP_690873	Q8NEK5	ZN548_HUMAN	zinc finger protein 548	34	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			breast(1)	1		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.221)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.026)		ATTGCTGTACCGTGATGTGAT	0.532			NA											5	238					0	0	0.000157383	0	0
ZNF134	7693	broad.mit.edu	37	19	58132703	58132703	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr19:58132703G>C	uc002qpn.2	+	3	1315	c.1216G>C	c.(1216-1218)GGG>CGG	p.G406R	ZNF134_uc002qpo.2_Missense_Mutation_p.G233R|ZNF211_uc010yhb.1_5'UTR	NM_003435	NP_003426	P52741	ZN134_HUMAN	zinc finger protein 134	406	C2H2-type 11.					nucleus	DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding				0		Colorectal(82;0.000256)|all_neural(62;0.0577)|Ovarian(87;0.156)		UCEC - Uterine corpus endometrioid carcinoma (67;0.168)|GBM - Glioblastoma multiforme(193;0.0265)		CAGTGAATGTGGGAAGGCCTA	0.478			NA											4	94					0	0	0.00024832	0	0
ACP1	52	broad.mit.edu	37	2	277079	277079	+	Silent	SNP	C	C	G	rs144534474		TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:277079C>G	uc002qwg.2	+	5	489	c.393C>G	c.(391-393)CCC>CCG	p.P131P	ACP1_uc002qwh.2_RNA|ACP1_uc002qwf.2_Silent_p.P131P	NM_007099	NP_009030	P24666	PPAC_HUMAN	acid phosphatase 1, soluble isoform b	131						cytoplasm|internal side of plasma membrane|nucleus|soluble fraction	acid phosphatase activity|identical protein binding|non-membrane spanning protein tyrosine phosphatase activity	p.P131P(1)		skin(1)	1	all_hematologic(175;0.0429)|Acute lymphoblastic leukemia(172;0.0627)	all_cancers(51;0.00175)|Lung NSC(108;0.216)|all_epithelial(98;0.236)		all cancers(51;0.000391)|Epithelial(75;0.00281)|OV - Ovarian serous cystadenocarcinoma(76;0.00542)|GBM - Glioblastoma multiforme(21;0.127)		TTGAAGATCCCTATTATGTAA	0.323			NA											5	79					0	0	1.23904e-05	0	0
KCNS3	3790	broad.mit.edu	37	2	18112979	18112979	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:18112979G>C	uc002rcv.2	+	3	1155	c.704G>C	c.(703-705)GGG>GCG	p.G235A	KCNS3_uc002rcw.2_Missense_Mutation_p.G235A	NM_002252	NP_002243	Q9BQ31	KCNS3_HUMAN	potassium voltage-gated channel	235	Helical; Name=Segment S2; (Potential).				energy reserve metabolic process|regulation of insulin secretion	Golgi apparatus|voltage-gated potassium channel complex	delayed rectifier potassium channel activity|potassium channel regulator activity			ovary(4)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.158)					TGGTTCACCGGGGAGCTTGCC	0.517			NA											5	140					0	0	1.23904e-05	0	0
NT5C1B	93034	broad.mit.edu	37	2	18736716	18736716	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:18736716C>G	uc010exr.2	-	9	1798	c.1694G>C	c.(1693-1695)CGG>CCG	p.R565P	NT5C1B_uc002rcy.2_3'UTR|RDH14_uc002rcx.3_Missense_Mutation_p.R251P	NM_033253	NP_150278	Q96P26	5NT1B_HUMAN	5' nucleotidase, cytosolic IB isoform 2	Error:Variant_position_missing_in_Q96P26_after_alignment					purine base metabolic process|purine nucleotide catabolic process	cytosol	5'-nucleotidase activity|magnesium ion binding|nucleotide binding			skin(2)|ovary(1)	3	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.177)	Ovarian(717;0.208)				CAGATTTGTCCGTACAATACC	0.478			NA											5	214					0	0	3.59834e-05	0	0
WDR35	57539	broad.mit.edu	37	2	20145669	20145669	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:20145669C>A	uc002rdi.2	-	17	1864	c.1756G>T	c.(1756-1758)GGA>TGA	p.G586*	WDR35_uc002rdj.2_Nonsense_Mutation_p.G575*|WDR35_uc010ext.2_RNA|WDR35_uc002rdh.2_Nonsense_Mutation_p.G151*|WDR35_uc002rdk.3_Nonsense_Mutation_p.G151*	NM_001006657	NP_001006658	Q9P2L0	WDR35_HUMAN	WD repeat domain 35 isoform 1	586										ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AACAACTCTCCAACTACTTGC	0.413			NA											9	185					0.000274275	0.00558288	0.000274275	1	0
APOB	338	broad.mit.edu	37	2	21242677	21242677	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:21242677G>T	uc002red.2	-	19	3045	c.2917C>A	c.(2917-2919)CTG>ATG	p.L973M		NM_000384	NP_000375	P04114	APOB_HUMAN	apolipoprotein B precursor	973					cholesterol homeostasis|cholesterol metabolic process|leukocyte migration|low-density lipoprotein particle clearance|low-density lipoprotein particle remodeling|platelet activation|positive regulation of cholesterol storage|positive regulation of macrophage derived foam cell differentiation|receptor-mediated endocytosis|response to virus	chylomicron remnant|clathrin-coated endocytic vesicle membrane|endoplasmic reticulum lumen|endoplasmic reticulum membrane|endosome lumen|endosome membrane|intermediate-density lipoprotein particle|low-density lipoprotein particle|mature chylomicron|microsome|plasma membrane|very-low-density lipoprotein particle	cholesterol transporter activity|enzyme binding|heparin binding|low-density lipoprotein particle receptor binding|phospholipid binding|protein heterodimerization activity			ovary(11)|skin(9)|central_nervous_system(3)|large_intestine(2)|upper_aerodigestive_tract(1)|pancreas(1)	27	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)				Atorvastatin(DB01076)	CAGTAATTCAGGCCAGGAAAG	0.537			NA											40	64					4.44401e-20	1.10378e-18	0.000509022	1	0
ITSN2	50618	broad.mit.edu	37	2	24533237	24533238	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:24533237_24533238CC>AA	uc002rfe.2	-	7	826_827	c.568_569GG>TT	c.(568-570)GGG>TTG	p.G190L	ITSN2_uc002rff.2_Missense_Mutation_p.G190L|ITSN2_uc002rfg.2_Missense_Mutation_p.G190L|ITSN2_uc010eyd.2_Missense_Mutation_p.G190L	NM_006277	NP_006268	Q9NZM3	ITSN2_HUMAN	intersectin 2 isoform 1	190					endocytosis|regulation of Rho protein signal transduction	cytoplasm	calcium ion binding|Rho guanyl-nucleotide exchange factor activity|SH3/SH2 adaptor activity			kidney(2)|ovary(1)|central_nervous_system(1)	4	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					ATAAGATGACCCATGAGGCAAT	0.342			NA											10	397					0	0	6.4e-05	0	0
ASXL2	55252	broad.mit.edu	37	2	25973143	25973143	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:25973143G>C	uc002rgs.2	-	11	1503	c.1282C>G	c.(1282-1284)CAG>GAG	p.Q428E	ASXL2_uc002rgt.1_Missense_Mutation_p.Q168E	NM_018263	NP_060733	Q76L83	ASXL2_HUMAN	additional sex combs like 2	428					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	metal ion binding|protein binding			pancreas(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					CACTCTGACTGGGAGACTACT	0.458			NA											9	447					0	0	3.86212e-05	0	0
CGREF1	10669	broad.mit.edu	37	2	27324192	27324192	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:27324192G>T	uc010eys.1	-	7	998	c.856C>A	c.(856-858)CAA>AAA	p.Q286K	CGREF1_uc010ylf.1_Intron|CGREF1_uc002rip.1_Intron|CGREF1_uc002riq.2_Missense_Mutation_p.Q303K|CGREF1_uc010eyr.1_Missense_Mutation_p.Q408K|CGREF1_uc002rir.1_Missense_Mutation_p.Q286K|CGREF1_uc002ris.2_Silent_p.P286P	NM_006569	NP_006560	Q99674	CGRE1_HUMAN	cell growth regulator with EF-hand domain 1	286					cell adhesion|cell cycle arrest|negative regulation of cell proliferation|response to stress	extracellular region	calcium ion binding			ovary(1)	1	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					AAGTCATTTTGGGTGTTCTTA	0.537			NA											11	215					0.000219431	0.00454042	0.000219431	1	0
ABHD1	84696	broad.mit.edu	37	2	27353581	27353581	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:27353581C>A	uc002rit.2	+	9	1347	c.1187C>A	c.(1186-1188)GCT>GAT	p.A396D	ABHD1_uc002riu.2_RNA|ABHD1_uc002riv.2_RNA	NM_032604	NP_115993	Q96SE0	ABHD1_HUMAN	abhydrolase domain-containing protein 1	396						integral to membrane	carboxylesterase activity				0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GACCTCAGGGCTCTCTTACCT	0.512			NA											23	40					3.7963e-18	9.27836e-17	0.00047179	1	0
TCF23	150921	broad.mit.edu	37	2	27375691	27375691	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:27375691C>A	uc010ylg.1	+	3	601	c.601C>A	c.(601-603)CTC>ATC	p.L201I		NM_175769	NP_786951	Q7RTU1	TCF23_HUMAN	transcription factor 23	201					cell differentiation|muscle organ development|regulation of transcription, DNA-dependent	nucleus					0	Acute lymphoblastic leukemia(172;0.155)|all_hematologic(175;0.215)					GGCAGATGCTCTCCTTTCCAC	0.537			NA											64	81					2.165e-29	5.62083e-28	0.000147903	1	0
IFT172	26160	broad.mit.edu	37	2	27708286	27708286	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:27708286G>T	uc002rku.2	-	2	175	c.124C>A	c.(124-126)CTG>ATG	p.L42M	IFT172_uc002rkw.2_Missense_Mutation_p.L42M|IFT172_uc010yls.1_Missense_Mutation_p.L21M|IFT172_uc010ezc.2_Missense_Mutation_p.L42M|IFT172_uc002rkv.2_Missense_Mutation_p.L42M|IFT172_uc010ylt.1_Missense_Mutation_p.L42M	NM_015662	NP_056477	Q9UG01	IF172_HUMAN	selective LIM binding factor homolog	42	WD 1.				cilium assembly	cilium	binding			large_intestine(1)|ovary(1)	2	Acute lymphoblastic leukemia(172;0.155)					TCATCATACAGCAAGACCACT	0.458			NA											46	82					5.85753e-14	1.37777e-12	0.000147903	1	0
PLB1	151056	broad.mit.edu	37	2	28812874	28812874	+	Silent	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:28812874G>C	uc002rmb.1	+	29	2019	c.2019G>C	c.(2017-2019)CTG>CTC	p.L673L	PLB1_uc010ezj.1_Silent_p.L662L|PLB1_uc002rmc.2_Silent_p.L361L|PLB1_uc002rmd.1_Silent_p.L183L	NM_153021	NP_694566	Q6P1J6	PLB1_HUMAN	phospholipase B1 precursor	673	4 X 308-326 AA approximate repeats.|2.|Extracellular (Potential).				lipid catabolic process|retinoid metabolic process|steroid metabolic process	apical plasma membrane|integral to membrane	lysophospholipase activity|phospholipase A2 activity|retinyl-palmitate esterase activity			ovary(4)|large_intestine(2)|skin(2)|breast(1)	9	Acute lymphoblastic leukemia(172;0.155)					TTGTTTAGCTGGAGCCTGTTG	0.542			NA											5	246					0	0	3.59834e-05	0	0
SOS1	6654	broad.mit.edu	37	2	39262581	39262581	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:39262581C>A	uc002rrk.3	-	7	966	c.925G>T	c.(925-927)GAT>TAT	p.D309Y	SOS1_uc010ynr.1_RNA|SOS1_uc002rrj.3_5'Flank|SOS1_uc002rrl.2_Missense_Mutation_p.D41Y	NM_005633	NP_005624	Q07889	SOS1_HUMAN	son of sevenless homolog 1	309	DH.		D -> Y (in NS4).		apoptosis|axon guidance|blood coagulation|epidermal growth factor receptor signaling pathway|fibroblast growth factor receptor signaling pathway|induction of apoptosis by extracellular signals|insulin receptor signaling pathway|leukocyte migration|nerve growth factor receptor signaling pathway|Ras protein signal transduction	cytosol	DNA binding|protein binding|Rho GTPase activator activity|Rho guanyl-nucleotide exchange factor activity			ovary(4)|breast(3)|lung(2)|central_nervous_system(1)	10		all_hematologic(82;0.21)				AGGAAACGATCATGAAAACCA	0.328			NA							Noonan_syndrome				38	70					1.57019e-19	3.87897e-18	0.000319135	1	0
DYNC2LI1	51626	broad.mit.edu	37	2	44016823	44016823	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:44016823G>T	uc002rtk.2	+	5	379	c.283G>T	c.(283-285)GAC>TAC	p.D95Y	DYNC2LI1_uc002rth.2_Missense_Mutation_p.D95Y|DYNC2LI1_uc002rti.2_Missense_Mutation_p.D95Y|DYNC2LI1_uc002rtj.2_Missense_Mutation_p.D95Y|DYNC2LI1_uc002rtl.2_Missense_Mutation_p.D95Y|DYNC2LI1_uc010ynz.1_5'UTR	NM_016008	NP_057092	Q8TCX1	DC2L1_HUMAN	dynein 2 light intermediate chain isoform 1	95						apical part of cell|axonemal dynein complex|cilium axoneme|cytoplasm|microtubule|motile primary cilium	motor activity			ovary(1)	1		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				CTCTTTATTGGACTTAATCAG	0.403			NA											53	93					1.02487e-32	2.67087e-31	0.000147903	1	0
PPM1B	5495	broad.mit.edu	37	2	44459476	44459477	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:44459476_44459477CC>AA	uc002rtw.2	+	6	1584_1585	c.1156_1157CC>AA	c.(1156-1158)CCA>AAA	p.P386K	PPM1B_uc002rtx.2_Intron	NM_177968	NP_808907	O75688	PPM1B_HUMAN	protein phosphatase 1B isoform 2	Error:Variant_position_missing_in_O75688_after_alignment					protein dephosphorylation	protein serine/threonine phosphatase complex	magnesium ion binding|manganese ion binding|protein binding|protein serine/threonine phosphatase activity			kidney(1)|skin(1)	2		all_hematologic(82;0.151)|Acute lymphoblastic leukemia(82;0.175)				TCTAGAAGACCCATGGTAGCCT	0.327			NA											9	318					0	0	6.4e-05	0	0
NRXN1	9378	broad.mit.edu	37	2	50149313	50149313	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:50149313C>G	uc010fbp.2	-	6	1905	c.1098G>C	c.(1096-1098)ACG>ACC	p.T366T	NRXN1_uc002rxb.3_Silent_p.T1100T|NRXN1_uc010fbq.2_Silent_p.T1471T|NRXN1_uc002rxe.3_Silent_p.T1401T|NRXN1_uc010yon.1_Silent_p.T66T|NRXN1_uc002rxa.3_Silent_p.T63T	NM_138735	NP_620072	P58400	NRX1B_HUMAN	neurexin 1 isoform beta precursor	366	Helical; (Potential).				angiogenesis|neuron cell-cell adhesion|neuronal signal transduction	cell surface|endocytic vesicle|integral to membrane|presynaptic membrane	cell adhesion molecule binding|receptor binding			ovary(2)	2		all_hematologic(82;0.152)|Acute lymphoblastic leukemia(82;0.192)	Lung(47;0.0813)|LUSC - Lung squamous cell carcinoma(58;0.116)			CGACCATACCCGTGGTGCTGC	0.552			NA											4	47					0	0	1.23904e-05	0	0
COMMD1	150684	broad.mit.edu	37	2	62132853	62132853	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:62132853G>C	uc002sbp.2	+	1	51	c.40G>C	c.(40-42)GGG>CGG	p.G14R		NM_152516	NP_689729	Q8N668	COMD1_HUMAN	MURR1	14					copper ion homeostasis|negative regulation of NF-kappaB transcription factor activity|positive regulation of protein ubiquitination|regulation of proteasomal ubiquitin-dependent protein catabolic process	cell junction|Cul2-RING ubiquitin ligase complex|cytoplasm|nucleolus	copper ion binding|protein homodimerization activity			ovary(1)	1	Lung NSC(7;0.035)|all_lung(7;0.0691)		LUSC - Lung squamous cell carcinoma(7;4.73e-07)|Epithelial(17;0.0216)|all cancers(80;0.0934)			ACCCCTGAGCGGGCTGCTGAA	0.682			NA											3	14					0	0	6.4e-05	0	0
RAB11FIP5	26056	broad.mit.edu	37	2	73303311	73303311	+	Splice_Site	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:73303311C>A	uc002siu.3	-	4	1810	c.1569_splice	c.e4-1	p.S523_splice	RAB11FIP5_uc002sis.3_Splice_Site|RAB11FIP5_uc002sit.3_Splice_Site_p.S445_splice	NM_015470	NP_056285	Q9BXF6	RFIP5_HUMAN	RAB11 family interacting protein 5 (class I)						protein transport	mitochondrial outer membrane|recycling endosome membrane	gamma-tubulin binding				0						GGGGTGGGGACTGCAAAGACA	0.627			NA											54	76					1.19403e-26	3.05389e-25	0.000147903	1	0
CTNNA2	1496	broad.mit.edu	37	2	80801386	80801386	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:80801386C>G	uc010ysh.1	+	12	1845	c.1840C>G	c.(1840-1842)CGC>GGC	p.R614G	CTNNA2_uc010yse.1_Missense_Mutation_p.R614G|CTNNA2_uc010ysf.1_Missense_Mutation_p.R614G|CTNNA2_uc010ysg.1_Missense_Mutation_p.R614G|CTNNA2_uc010ysi.1_Missense_Mutation_p.R246G	NM_004389	NP_004380	P26232	CTNA2_HUMAN	catenin, alpha 2 isoform 1	614					axonogenesis|brain morphogenesis|cell-cell adhesion|dendrite morphogenesis|muscle cell differentiation|positive regulation of muscle cell differentiation|prepulse inhibition|radial glia guided migration of Purkinje cell|regulation of synapse structural plasticity	actin cytoskeleton|axon|cytosol	cadherin binding|structural constituent of cytoskeleton			pancreas(4)|lung(3)|breast(1)|skin(1)	9						CGATGCCTCTCGCCTGGTGTA	0.527			NA											5	154					0	0	3.59834e-05	0	0
POLR1A	25885	broad.mit.edu	37	2	86266540	86266540	+	Silent	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:86266540G>C	uc002sqs.2	-	26	4165	c.3786C>G	c.(3784-3786)CCC>CCG	p.P1262P	POLR1A_uc010ytb.1_Silent_p.P628P|POLR1A_uc002sqt.1_Silent_p.P285P	NM_015425	NP_056240	O95602	RPA1_HUMAN	DNA-directed RNA polymerase I A	1262					termination of RNA polymerase I transcription|transcription elongation from RNA polymerase I promoter|transcription initiation from RNA polymerase I promoter	DNA-directed RNA polymerase I complex|nucleoplasm	DNA binding|DNA-directed RNA polymerase activity|protein binding|zinc ion binding			ovary(2)|skin(1)	3						CGCTCATCATGGGTGTCTTGA	0.532			NA											6	281					0	0	3.59834e-05	0	0
CD8B	926	broad.mit.edu	37	2	87042749	87042750	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:87042749_87042750GG>TT	uc002srw.2	-	6	762_763	c.712_713CC>AA	c.(712-714)CCA>AAA	p.P238K	RMND5A_uc002srs.3_Intron|CD8B_uc002srx.2_3'UTR|CD8B_uc002sry.2_Missense_Mutation_p.P208K|CD8B_uc010fgt.2_Missense_Mutation_p.H196N	NM_172213	NP_757362	P10966	CD8B_HUMAN	CD8b antigen isoform 2 precursor	Error:Variant_position_missing_in_P10966_after_alignment					immune response|regulation of defense response to virus by virus|regulation of immune response|T cell activation|transmembrane receptor protein tyrosine kinase signaling pathway|viral reproduction	early endosome|extracellular region|integral to plasma membrane|T cell receptor complex	coreceptor activity|MHC class I protein binding			upper_aerodigestive_tract(1)|skin(1)	2						CAGGATCCATGGGTTAAGCAGC	0.48			NA											12	583					0	0	6.4e-05	0	0
ZNF514	84874	broad.mit.edu	37	2	95815548	95815548	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:95815548C>G	uc002sue.1	-	5	1056	c.682G>C	c.(682-684)GGA>CGA	p.G228R	ZNF514_uc002sud.1_Missense_Mutation_p.G301R	NM_032788	NP_116177	Q96K75	ZN514_HUMAN	zinc finger protein 514	228					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						GGCTTTTCTCCAGTGTGACAT	0.428			NA											5	223					0	0	3.59834e-05	0	0
SNRNP200	23020	broad.mit.edu	37	2	96968949	96968950	+	Missense_Mutation	DNP	CG	CG	AT			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:96968949_96968950CG>AT	uc002svu.2	-	3	414_415	c.328_329CG>AT	c.(328-330)CGG>ATG	p.R110M		NM_014014	NP_054733	O75643	U520_HUMAN	activating signal cointegrator 1 complex subunit	110						catalytic step 2 spliceosome|nucleoplasm|U5 snRNP	ATP binding|ATP-dependent helicase activity|nucleic acid binding|protein binding			ovary(5)|skin(4)|large_intestine(1)	10						ATAGGTCTCCCGAGTCTCTTTA	0.411			NA											10	319					0	0	6.4e-05	0	0
INPP4A	3631	broad.mit.edu	37	2	99182490	99182490	+	Splice_Site	SNP	A	A	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:99182490A>C	uc002syy.2	+	22	2688	c.2295_splice	c.e22-2	p.R765_splice	INPP4A_uc010yvj.1_Splice_Site_p.R726_splice|INPP4A_uc010yvk.1_Splice_Site_p.R726_splice|INPP4A_uc002syx.2_Splice_Site_p.R760_splice|INPP4A_uc010fik.2_Splice_Site_p.R94_splice	NM_001134224	NP_001127696	Q96PE3	INP4A_HUMAN	inositol polyphosphate-4-phosphatase, type 1						signal transduction		phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity|phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity			kidney(1)	1						ACCTTTCTCCAGCGACGGGTT	0.657			NA											3	9					0	0	0.00024832	0	0
ST6GAL2	84620	broad.mit.edu	37	2	107460085	107460085	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:107460085C>G	uc002tdq.2	-	2	468	c.349G>C	c.(349-351)GGG>CGG	p.G117R	ST6GAL2_uc002tdr.2_Missense_Mutation_p.G117R|ST6GAL2_uc002tds.3_Missense_Mutation_p.G117R	NM_001142351	NP_001135823	Q96JF0	SIAT2_HUMAN	ST6 beta-galactosamide	117	Lumenal (Potential).				growth|multicellular organismal development|oligosaccharide metabolic process|protein glycosylation	Golgi cisterna membrane|integral to Golgi membrane	beta-galactoside alpha-2,6-sialyltransferase activity			pancreas(6)|ovary(4)|skin(1)	11						GATTTTCTCCCCACCTGGGAT	0.532			NA											5	129					0	0	3.59834e-05	0	0
IL1A	3552	broad.mit.edu	37	2	113539268	113539268	+	Missense_Mutation	SNP	C	C	G	rs138861340	byFrequency	TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:113539268C>G	uc002tig.2	-	4	1192	c.232G>C	c.(232-234)GGG>CGG	p.G78R		NM_000575	NP_000566	P01583	IL1A_HUMAN	interleukin 1, alpha proprotein	78					anti-apoptosis|apoptosis|cell proliferation|cellular response to heat|cytokine-mediated signaling pathway|fever generation|immune response|negative regulation of cell proliferation|positive regulation of angiogenesis|positive regulation of cell division|positive regulation of cytokine secretion|positive regulation of interleukin-2 biosynthetic process|positive regulation of mitosis|positive regulation vascular endothelial growth factor production|response to copper ion	cytosol|extracellular space	copper ion binding|cytokine activity|interleukin-1 receptor binding			lung(1)	1						AGAACCTTCCCGTTGGTTGCT	0.478			NA											5	201					0	0	1.23904e-05	0	0
PAX8	7849	broad.mit.edu	37	2	114002024	114002024	+	Silent	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:114002024G>C	uc010yxt.1	-	4	535	c.369C>G	c.(367-369)CCC>CCG	p.P123P	PAX8_uc010yxu.1_Silent_p.P123P|PAX8_uc010yxv.1_Silent_p.P123P|PAX8_uc002tjm.2_Silent_p.P123P|PAX8_uc002tjn.2_Silent_p.P123P|PAX8_uc010fku.1_Silent_p.P123P|LOC654433_uc002tjq.3_Intron|LOC654433_uc010fks.2_Intron|LOC654433_uc010fkt.2_Intron|LOC654433_uc002tjr.3_Intron	NM_003466	NP_003457	Q06710	PAX8_HUMAN	paired box 8 isoform PAX8A	123	Paired.				branching involved in ureteric bud morphogenesis|cellular response to gonadotropin stimulus|central nervous system development|mesenchymal to epithelial transition involved in metanephros morphogenesis|mesonephros development|metanephric collecting duct development|metanephric comma-shaped body morphogenesis|metanephric distal convoluted tubule development|metanephric nephron tubule formation|metanephric S-shaped body morphogenesis|negative regulation of mesenchymal stem cell apoptosis involved in metanephric nephron morphogenesis|otic vesicle development|positive regulation of branching involved in ureteric bud morphogenesis|positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis|positive regulation of metanephric DCT cell differentiation|positive regulation of thyroid hormone generation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription, DNA-dependent|pronephric field specification|regulation of metanephric nephron tubule epithelial cell differentiation|regulation of thyroid-stimulating hormone secretion|thyroid gland development|transcription, DNA-dependent	nucleoplasm	protein binding|RNA polymerase II core promoter sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|thyroid-stimulating hormone receptor activity			ovary(1)|lung(1)	2						AGCTGACACTGGGCACAGTGT	0.552	Ovarian(188;7 2067 9084 29802 29892)		NA	T	PPARG	follicular thyroid		Thyroid dysgenesis 						7	149					0	0	0.000157383	0	0
PCDP1	200373	broad.mit.edu	37	2	120395970	120395970	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:120395970C>G	uc002tmb.2	+	21	2344	c.1252C>G	c.(1252-1254)CAA>GAA	p.Q418E		NM_001029996	NP_001025167	Q4G0U5	PCDP1_HUMAN	primary ciliary dyskinesia protein 1	704						cilium	calmodulin binding				0	Colorectal(110;0.196)					TCCTGTCACCCAAAAGCAGTT	0.537			NA											4	74					0	0	0.00024832	0	0
TUBA3D	113457	broad.mit.edu	37	2	132240385	132240385	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:132240385C>G	uc002tsu.3	+	5	1424	c.1317C>G	c.(1315-1317)TCC>TCG	p.S439S		NM_080386	NP_525125	Q13748	TBA3C_HUMAN	tubulin, alpha 3d	439					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity				0				BRCA - Breast invasive adenocarcinoma(221;0.13)		GCGTGGATTCCGTGGAAGCTG	0.582	Ovarian(137;2059 2432 35543 39401)		NA											4	181					0	0	1.23904e-05	0	0
LOC150776	150776	broad.mit.edu	37	2	132277823	132277823	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:132277823A>T	uc002tsz.3	+	3	850	c.403A>T	c.(403-405)AGC>TGC	p.S135C	LOC150776_uc002tsy.3_RNA					Homo sapiens cDNA FLJ41352 fis, clone BRAWH2014645.												0						CCCCAGGCTCAGCCTGCGCTT	0.687			NA											7	6					0	0	0.000274275	0	0
LRP1B	53353	broad.mit.edu	37	2	141264383	141264383	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:141264383C>T	uc002tvj.1	-	53	9475	c.8503G>A	c.(8503-8505)GAT>AAT	p.D2835N		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	2835	Extracellular (Potential).|LDL-receptor class A 18.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		GGTGACTCATCAGAGCCATCT	0.368	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			52	96					0	0	0.000147903	0	0
LRP1B	53353	broad.mit.edu	37	2	141598583	141598583	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:141598583G>T	uc002tvj.1	-	30	5990	c.5018C>A	c.(5017-5019)ACG>AAG	p.T1673K		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B	1673	Extracellular (Potential).|LDL-receptor class B 15.				protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		ATTAATTTGCGTTTCATCAAA	0.418	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			36	56					2.20474e-14	5.21257e-13	0.000109025	1	0
ZEB2	9839	broad.mit.edu	37	2	145156296	145156296	+	Missense_Mutation	SNP	A	A	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:145156296A>C	uc002tvu.2	-	8	2938	c.2458T>G	c.(2458-2460)TTA>GTA	p.L820V	ZEB2_uc002tvv.2_Missense_Mutation_p.L814V|ZEB2_uc010zbm.1_Missense_Mutation_p.L791V|ZEB2_uc010fnp.2_Intron|ZEB2_uc010fnq.1_Missense_Mutation_p.L849V	NM_014795	NP_055610	O60315	ZEB2_HUMAN	zinc finger homeobox 1b	820						cytoplasm|nucleolus	phosphatase regulator activity|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|SMAD binding|zinc ion binding			ovary(5)|pancreas(2)|upper_aerodigestive_tract(1)|large_intestine(1)	9				BRCA - Breast invasive adenocarcinoma(221;0.112)		TGTTTTGGTAATGACAAGTCT	0.383	Melanoma(33;1235 1264 5755 16332)		NA											74	99					0	0	0.000147903	0	0
KIF5C	3800	broad.mit.edu	37	2	149799276	149799276	+	Splice_Site	SNP	T	T	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:149799276T>A	uc010zbu.1	+	7	957	c.589_splice	c.e7+2	p.N197_splice		NM_004522	NP_004513	O60282	KIF5C_HUMAN	kinesin family member 5C						microtubule-based movement|organelle organization	cytoplasm|kinesin complex|microtubule	ATP binding|microtubule motor activity			skin(1)	1				BRCA - Breast invasive adenocarcinoma(221;0.108)		CTGTGACAAGTAAGCATGGTG	0.527			NA											8	5					0	0	0.000157383	0	0
ERMN	57471	broad.mit.edu	37	2	158182141	158182141	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:158182141G>C	uc002tzh.2	-	1	276	c.14C>G	c.(13-15)CCG>CGG	p.P5R	ERMN_uc010zcj.1_5'Flank|ERMN_uc010zck.1_Missense_Mutation_p.P5R|ERMN_uc002tzi.2_Missense_Mutation_p.P18R	NM_020711	NP_065762	Q8TAM6	ERMIN_HUMAN	ermin, ERM-like protein isoform b	5						cytoplasm|cytoskeleton				ovary(1)|skin(1)	2						AAATGTAGCCGGAACATCTGT	0.448			NA											4	156					0	0	1.23904e-05	0	0
IFIH1	64135	broad.mit.edu	37	2	163174366	163174367	+	Missense_Mutation	DNP	CG	CG	AT			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:163174366_163174367CG>AT	uc002uce.2	-	1	673_674	c.451_452CG>AT	c.(451-453)CGG>ATG	p.R151M	IFIH1_uc002ucf.2_Missense_Mutation_p.R151M	NM_022168	NP_071451	Q9BYX4	IFIH1_HUMAN	interferon induced with helicase C domain 1	151	CARD 2.				detection of virus|innate immune response|interspecies interaction between organisms|negative regulation of type I interferon production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|regulation of apoptosis	cytosol|nucleus	ATP binding|DNA binding|double-stranded RNA binding|helicase activity|protein binding|ribonucleoprotein binding|zinc ion binding			ovary(1)	1						GACACCTACCCGGTTTCTGTCT	0.49			NA											13	583					0	0	6.4e-05	0	0
SCN9A	6335	broad.mit.edu	37	2	167056049	167056049	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:167056049C>G	uc010fpl.2	-	27	5408	c.5067G>C	c.(5065-5067)TGG>TGC	p.W1689C	uc002udp.2_Intron	NM_002977	NP_002968	Q15858	SCN9A_HUMAN	sodium channel, voltage-gated, type IX, alpha	1700	IV.					voltage-gated sodium channel complex	voltage-gated sodium channel activity			ovary(6)|central_nervous_system(5)|skin(2)	13					Lamotrigine(DB00555)|Lidocaine(DB00281)	GCAATCCATCCCAGCCAGCAG	0.418			NA											6	292					0	0	3.59834e-05	0	0
XIRP2	129446	broad.mit.edu	37	2	168100039	168100039	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:168100039G>T	uc002udx.2	+	8	2155	c.2137G>T	c.(2137-2139)GTT>TTT	p.V713F	XIRP2_uc010fpn.2_Intron|XIRP2_uc010fpo.2_Intron|XIRP2_uc010fpp.2_Intron|XIRP2_uc002udy.2_Missense_Mutation_p.V538F|XIRP2_uc010fpq.2_Missense_Mutation_p.V491F|XIRP2_uc010fpr.2_Intron	NM_152381	NP_689594	A4UGR9	XIRP2_HUMAN	xin actin-binding repeat containing 2 isoform 1	538					actin cytoskeleton organization	cell junction	actin binding			skin(7)|ovary(6)|pancreas(1)	14						AGTGGATGAGGTTCATTTACT	0.363			NA											14	28					3.41278e-10	7.78771e-09	5.01169e-05	1	0
LRP2	4036	broad.mit.edu	37	2	170060754	170060754	+	Silent	SNP	C	C	G	rs140698184	by1000genomes	TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:170060754C>G	uc002ues.2	-	42	7956	c.7743G>C	c.(7741-7743)ACG>ACC	p.T2581T		NM_004525	NP_004516	P98164	LRP2_HUMAN	low density lipoprotein-related protein 2	2581	LDL-receptor class B 28.|Extracellular (Potential).				hormone biosynthetic process|protein glycosylation|receptor-mediated endocytosis|vitamin D metabolic process	coated pit|integral to membrane|lysosome	calcium ion binding|receptor activity|SH3 domain binding			ovary(13)|skin(6)|central_nervous_system(4)|large_intestine(3)|kidney(2)|pancreas(1)	29				STAD - Stomach adenocarcinoma(1183;0.000766)|COAD - Colon adenocarcinoma(177;0.0101)	Gentamicin(DB00798)|Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)|Urokinase(DB00013)	GATCCACGCCCGTCAGAGTGC	0.423			NA											8	264					0	0	0.000274275	0	0
HAT1	8520	broad.mit.edu	37	2	172823010	172823010	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:172823010C>G	uc002uhi.2	+	7	768	c.692C>G	c.(691-693)CCA>CGA	p.P231R	HAT1_uc010fqi.2_Missense_Mutation_p.P66R|HAT1_uc002uhj.2_Missense_Mutation_p.P146R	NM_003642	NP_003633	O14929	HAT1_HUMAN	histone acetyltransferase 1	231					chromatin silencing at telomere|DNA packaging	cytoplasm|nuclear matrix|nucleoplasm	histone acetyltransferase activity|protein binding			large_intestine(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(117;0.216)			TATGTGTACCCAGACAAAACC	0.403			NA											4	90					0	0	1.23904e-05	0	0
SP3	6670	broad.mit.edu	37	2	174820400	174820400	+	Silent	SNP	C	C	A	rs146827142		TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:174820400C>A	uc002uig.2	-	4	1004	c.840G>T	c.(838-840)TCG>TCT	p.S280S	SP3_uc002uie.2_Silent_p.S212S|SP3_uc002uif.2_Silent_p.S227S|SP3_uc010zel.1_Silent_p.S277S	NM_003111	NP_003102	Q02447	SP3_HUMAN	Sp3 transcription factor isoform 1	280					negative regulation of transcription, DNA-dependent|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	PML body	protein binding|zinc ion binding		EWSR1/SP3(3)	soft_tissue(3)|upper_aerodigestive_tract(1)|ovary(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.185)			GAGAACTGCCCGAGAGTCCCA	0.443			NA											9	164					0.000274275	0.00558288	0.000274275	1	0
TTN	7273	broad.mit.edu	37	2	179407625	179407625	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:179407625G>C	uc010zfg.1	-	297	89476	c.89252C>G	c.(89251-89253)CCA>CGA	p.P29751R	uc002umo.2_Intron|uc002ump.1_Intron|TTN_uc010zfh.1_Missense_Mutation_p.P23446R|TTN_uc010zfi.1_Missense_Mutation_p.P23379R|TTN_uc010zfj.1_Missense_Mutation_p.P23254R	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	30678							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			TCTGCCAGCTGGGACATGGAT	0.453			NA											6	397					0	0	8.12818e-05	0	0
TTN	7273	broad.mit.edu	37	2	179539774	179539774	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:179539774G>C	uc010zfg.1	-	145	30925	c.30701C>G	c.(30700-30702)CCA>CGA	p.P10234R	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Missense_Mutation_p.P6895R|TTN_uc010fre.1_Intron|TTN_uc010zfk.1_5'Flank|TTN_uc002una.1_RNA|TTN_uc010frf.1_Intron	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	11161							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			ACCTTCAACTGGTAGAACTTC	0.323			NA											4	57					0	0	0.00024832	0	0
TTN	7273	broad.mit.edu	37	2	179585148	179585149	+	Nonsense_Mutation	DNP	CC	CC	AA			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:179585148_179585149CC>AA	uc010zfg.1	-	77	19832_19833	c.19608_19609GG>TT	c.(19606-19611)GTGGGA>GTTTGA	p.G6537*	TTN_uc010zfh.1_Intron|TTN_uc010zfi.1_Intron|TTN_uc010zfj.1_Intron|TTN_uc002umz.1_Nonsense_Mutation_p.G3198*	NM_133378	NP_596869	Q8WZ42	TITIN_HUMAN	titin isoform N2-A	7464							ATP binding|nucleic acid binding|protein serine/threonine kinase activity|protein tyrosine kinase activity			ovary(58)|stomach(19)|large_intestine(17)|lung(16)|skin(16)|breast(10)|pancreas(7)|kidney(4)|central_nervous_system(3)|urinary_tract(2)|upper_aerodigestive_tract(1)	153			OV - Ovarian serous cystadenocarcinoma(117;0.023)|Epithelial(96;0.0454)|all cancers(119;0.134)			GTGTCACTTCCCACCTCATTAG	0.376			NA											11	201					0	0	6.4e-05	0	0
ITGA4	3676	broad.mit.edu	37	2	182347321	182347321	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:182347321C>G	uc002unu.2	+	9	1747	c.984C>G	c.(982-984)CCC>CCG	p.P328P	ITGA4_uc010zfl.1_Silent_p.P328P	NM_000885	NP_000876	P13612	ITA4_HUMAN	integrin alpha 4 precursor	328	FG-GAP 5.|Extracellular (Potential).				blood coagulation|integrin-mediated signaling pathway|leukocyte cell-cell adhesion|leukocyte migration|regulation of immune response	integrin complex	identical protein binding|receptor activity			ovary(3)|lung(1)|central_nervous_system(1)|pancreas(1)	6			OV - Ovarian serous cystadenocarcinoma(117;0.0593)		Natalizumab(DB00108)	TGGGAGCACCCATGCAGAGCA	0.498			NA											5	236					0	0	1.23904e-05	0	0
ZNF804A	91752	broad.mit.edu	37	2	185801408	185801408	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:185801408C>T	uc002uph.2	+	4	1879	c.1285C>T	c.(1285-1287)CTT>TTT	p.L429F		NM_194250	NP_919226	Q7Z570	Z804A_HUMAN	zinc finger protein 804A	429						intracellular	zinc ion binding			ovary(6)|skin(3)|large_intestine(1)|pancreas(1)	11						TGTACCTGTCCTTAACAAACA	0.373			NA											107	150					0	0	0.000147903	0	0
COL5A2	1290	broad.mit.edu	37	2	189945770	189945770	+	Splice_Site	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:189945770C>G	uc002uqk.2	-	13	1128	c.853_splice	c.e13-1	p.G285_splice	COL5A2_uc010frx.2_Splice_Site_p.G38_splice	NM_000393	NP_000384	P05997	CO5A2_HUMAN	alpha 2 type V collagen preproprotein						axon guidance|collagen fibril organization|eye morphogenesis|skin development	collagen type V	extracellular matrix structural constituent			ovary(2)	2			OV - Ovarian serous cystadenocarcinoma(117;0.0106)|Epithelial(96;0.127)			CACGAGCTCCCTGGGAGGAAA	0.398			NA											4	120					0	0	0.00024832	0	0
SLC40A1	30061	broad.mit.edu	37	2	190439933	190439933	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:190439933C>G	uc002uqp.3	-	3	576	c.225G>C	c.(223-225)CTG>CTC	p.L75L	SLC40A1_uc002uqq.2_Silent_p.L75L	NM_014585	NP_055400	Q9NP59	S40A1_HUMAN	solute carrier family 40 (iron-regulated	75	Helical; (Potential).				anatomical structure morphogenesis|cellular iron ion homeostasis	cytoplasm|integral to plasma membrane	iron ion transmembrane transporter activity|protein binding			ovary(1)	1			OV - Ovarian serous cystadenocarcinoma(117;0.000917)|Epithelial(96;0.014)|all cancers(119;0.0491)			TGATGGCTCCCAGGACCAGAA	0.498			NA											6	273					0	0	3.59834e-05	0	0
ANKAR	150709	broad.mit.edu	37	2	190606123	190606123	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:190606123C>G	uc002uqw.1	+	19	3543	c.3543C>G	c.(3541-3543)ACC>ACG	p.T1181T	ANKAR_uc002uqu.2_RNA|ANKAR_uc002uqx.1_RNA|ANKAR_uc002uqy.1_Silent_p.T348T	NM_144708	NP_653309	Q7Z5J8	ANKAR_HUMAN	ankyrin and armadillo repeat containing	1252						integral to membrane	binding			ovary(2)|pancreas(1)|skin(1)	4			OV - Ovarian serous cystadenocarcinoma(117;0.00156)|Epithelial(96;0.0256)|all cancers(119;0.0744)			AAGCATTTACCACATTAGGAA	0.318			NA											4	107					0	0	3.59834e-05	0	0
HIBCH	26275	broad.mit.edu	37	2	191109623	191109623	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:191109623T>A	uc002uru.2	-	11	964	c.881A>T	c.(880-882)GAG>GTG	p.E294V	HIBCH_uc002urv.2_Missense_Mutation_p.E294V	NM_014362	NP_055177	Q6NVY1	HIBCH_HUMAN	3-hydroxyisobutyryl-Coenzyme A hydrolase isoform	294					branched chain family amino acid catabolic process	mitochondrial matrix	3-hydroxyisobutyryl-CoA hydrolase activity|protein binding				0			OV - Ovarian serous cystadenocarcinoma(117;0.000586)|Epithelial(96;0.0286)|all cancers(119;0.0814)			CTTCAATTGCTCTAGGGCAAA	0.398			NA											64	114					0	0	0.000147903	0	0
DNAH7	56171	broad.mit.edu	37	2	196746569	196746569	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:196746569G>T	uc002utj.3	-	36	6012	c.5911C>A	c.(5911-5913)CCT>ACT	p.P1971T		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	1971	AAA 3 (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						AATATTGAAGGCTTTTGATGG	0.373			NA											60	93					4.13886e-29	1.0705e-27	0.000147903	1	0
DNAH7	56171	broad.mit.edu	37	2	196912157	196912157	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:196912157C>A	uc002utj.3	-	5	418	c.317G>T	c.(316-318)GGA>GTA	p.G106V		NM_018897	NP_061720	Q8WXX0	DYH7_HUMAN	dynein, axonemal, heavy chain 7	106	Stem (By similarity).				ciliary or flagellar motility|microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|microtubule motor activity			skin(10)|ovary(2)	12						AGTAGATGGTCCAACATAACT	0.323			NA											87	137					3.07327e-39	8.0549e-38	0.000147903	1	0
ZDBF2	57683	broad.mit.edu	37	2	207169659	207169659	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:207169659C>T	uc002vbp.2	+	5	657	c.407C>T	c.(406-408)TCA>TTA	p.S136L		NM_020923	NP_065974	Q9HCK1	ZDBF2_HUMAN	zinc finger, DBF-type containing 2	136							nucleic acid binding|zinc ion binding			ovary(3)	3						GTTCGACCATCAGTTATTCAA	0.448			NA											7	25					0	0	0.000274275	0	0
CRYGB	1419	broad.mit.edu	37	2	209010521	209010521	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:209010521G>A	uc002vcp.3	-	2	262	c.229C>T	c.(229-231)CGC>TGC	p.R77C		NM_005210	NP_005201	P07316	CRGB_HUMAN	crystallin, gamma B	77	Beta/gamma crystallin 'Greek key' 2.				visual perception		structural constituent of eye lens				0				Epithelial(149;0.0641)|LUSC - Lung squamous cell carcinoma(261;0.0703)|Lung(261;0.132)		CAGCAGGAGCGGATGGAGTCG	0.498			NA											5	102					0	0	3.59834e-05	0	0
PTH2R	5746	broad.mit.edu	37	2	209353827	209353827	+	Silent	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:209353827C>T	uc002vdb.2	+	11	1380	c.1167C>T	c.(1165-1167)CTC>CTT	p.L389L	PTH2R_uc010zjb.1_Silent_p.L400L|PTH2R_uc010fuo.1_RNA	NM_005048	NP_005039	P49190	PTH2R_HUMAN	parathyroid hormone 2 receptor precursor	389	Extracellular (Potential).					integral to plasma membrane	parathyroid hormone receptor activity			ovary(1)|breast(1)|skin(1)	3				Epithelial(149;0.0684)|Lung(261;0.0785)|LUSC - Lung squamous cell carcinoma(261;0.0836)		TCACTGGGCTCGGGTGGGAGA	0.488			NA											29	51					0	0	0.000227799	0	0
XRCC5	7520	broad.mit.edu	37	2	217012886	217012886	+	Silent	SNP	C	C	G	rs141533226		TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:217012886C>G	uc002vfy.2	+	14	1697	c.1557C>G	c.(1555-1557)CCC>CCG	p.P519P	XRCC5_uc002vfz.2_Silent_p.P405P	NM_021141	NP_066964	P13010	XRCC5_HUMAN	ATP-dependent DNA helicase II	519	Pro-rich.				double-strand break repair via nonhomologous end joining|initiation of viral infection|negative regulation of transcription, DNA-dependent|provirus integration|telomere maintenance|transcription, DNA-dependent	Ku70:Ku80 complex|nonhomologous end joining complex|nuclear telomere cap complex|nucleoplasm	ATP binding|ATP-dependent DNA helicase activity|double-stranded DNA binding|protein C-terminus binding|telomeric DNA binding|transcription regulatory region DNA binding			lung(1)|kidney(1)	2		Renal(323;0.0328)		Epithelial(149;9.78e-06)|all cancers(144;0.000632)|LUSC - Lung squamous cell carcinoma(224;0.00871)|Lung(261;0.0117)		TGAATCCTCCCGCTGAGGTGA	0.443			NA						Direct_reversal_of_damage|NHEJ					4	135					0	0	0.00024832	0	0
DOCK10	55619	broad.mit.edu	37	2	225659777	225659777	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:225659777G>T	uc010fwz.1	-	45	5212	c.4973C>A	c.(4972-4974)ACT>AAT	p.T1658N	DOCK10_uc002vob.2_Missense_Mutation_p.T1652N|DOCK10_uc002voa.2_Missense_Mutation_p.T314N|DOCK10_uc002voc.2_Missense_Mutation_p.T512N	NM_014689	NP_055504	Q96BY6	DOC10_HUMAN	dedicator of cytokinesis 10	1658	DHR-2.						GTP binding			ovary(2)	2		Renal(207;0.0113)|all_lung(227;0.0486)|Lung NSC(271;0.0653)|all_hematologic(139;0.14)		Epithelial(121;2.37e-10)|all cancers(144;2.26e-07)|Lung(261;0.0143)|LUSC - Lung squamous cell carcinoma(224;0.0178)		TATACGCTTAGTCAGGTCCTT	0.468			NA											65	102					8.07507e-42	2.1409e-40	0.000147903	1	0
IRS1	3667	broad.mit.edu	37	2	227663340	227663340	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:227663340C>G	uc002voh.3	-	1	167	c.115G>C	c.(115-117)GGG>CGG	p.G39R		NM_005544	NP_005535	P35568	IRS1_HUMAN	insulin receptor substrate 1	39	PH.|Mediates interaction with PHIP (By similarity).				fibroblast growth factor receptor signaling pathway|glucose homeostasis|insulin receptor signaling pathway|negative regulation of insulin receptor signaling pathway|negative regulation of insulin secretion|nerve growth factor receptor signaling pathway|phosphatidylinositol 3-kinase cascade|phosphatidylinositol-mediated signaling|positive regulation of fatty acid beta-oxidation|positive regulation of glucose import|positive regulation of glycogen biosynthetic process|positive regulation of insulin receptor signaling pathway|positive regulation of phosphatidylinositol 3-kinase activity	caveola|cytosol|insulin receptor complex|microsome|nucleus	insulin receptor binding|insulin-like growth factor receptor binding|phosphatidylinositol 3-kinase binding|protein kinase C binding|SH2 domain binding|transmembrane receptor protein tyrosine kinase adaptor activity			lung(5)|central_nervous_system(4)|ovary(2)|pancreas(1)	12		Renal(207;0.023)|all_lung(227;0.0994)|all_hematologic(139;0.118)|Esophageal squamous(248;0.23)		Epithelial(121;3.03e-11)|all cancers(144;2.42e-08)|Lung(261;0.00712)|LUSC - Lung squamous cell carcinoma(224;0.0137)		GCCGGGCCCCCAGCCTCGCTG	0.632			NA											4	70					0	0	0.00024832	0	0
GPR55	9290	broad.mit.edu	37	2	231775219	231775219	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:231775219G>T	uc002vrg.2	-	2	652	c.459C>A	c.(457-459)AGC>AGA	p.S153R	GPR55_uc002vrf.2_RNA|GPR55_uc010fxs.1_Missense_Mutation_p.S153R	NM_005683	NP_005674	Q9Y2T6	GPR55_HUMAN	G protein-coupled receptor 55	153	Helical; Name=4; (Potential).				activation of phospholipase C activity|bone resorption|negative regulation of osteoclast differentiation|positive regulation of ERK1 and ERK2 cascade|positive regulation of Rho protein signal transduction	integral to plasma membrane	cannabinoid receptor activity			ovary(1)	1		Renal(207;0.0112)|all_lung(227;0.0741)|all_hematologic(139;0.0748)|Acute lymphoblastic leukemia(138;0.167)|Lung NSC(271;0.204)		Epithelial(121;1.04e-11)|all cancers(144;4.22e-09)|LUSC - Lung squamous cell carcinoma(224;0.0119)|Lung(119;0.0145)		AGATAGGGATGCTTCCGGTCC	0.547			NA											32	56					1.06801e-11	2.48241e-10	0.000279167	1	0
HJURP	55355	broad.mit.edu	37	2	234750475	234750475	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:234750475C>G	uc002vvg.2	-	8	1017	c.951G>C	c.(949-951)CAG>CAC	p.Q317H	HJURP_uc010znd.1_Missense_Mutation_p.Q256H|HJURP_uc010zne.1_Missense_Mutation_p.Q225H	NM_018410	NP_060880	Q8NCD3	HJURP_HUMAN	Holliday junction recognition protein	317					cell cycle|CenH3-containing nucleosome assembly at centromere|centromeric core chromatin assembly|chromosome segregation|regulation of DNA binding|regulation of protein complex assembly	condensed chromosome kinetochore|cytoplasm|nucleolus|nucleoplasm	DNA binding|histone binding			ovary(1)	1		Breast(86;0.00204)|all_lung(227;0.00433)|Renal(207;0.00685)|all_hematologic(139;0.0116)|Acute lymphoblastic leukemia(138;0.0326)|Lung NSC(271;0.0719)|Lung SC(224;0.128)		Epithelial(121;2.01e-18)|BRCA - Breast invasive adenocarcinoma(100;0.000186)|Lung(119;0.00521)|LUSC - Lung squamous cell carcinoma(224;0.00829)		TGGAGCTCCTCTGAGAACGTC	0.463			NA											21	19					0	0	0.000175454	0	0
IQCA1	79781	broad.mit.edu	37	2	237300647	237300647	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:237300647G>T	uc002vvz.1	-	11	1567	c.1385C>A	c.(1384-1386)CCA>CAA	p.P462Q	IQCA1_uc002vwb.2_Missense_Mutation_p.P469Q|IQCA1_uc002vwa.1_RNA|IQCA1_uc010zni.1_Missense_Mutation_p.P421Q	NM_024726	NP_079002	Q86XH1	IQCA1_HUMAN	IQ motif containing with AAA domain 1	462	Lys-rich.						ATP binding			ovary(1)	1						TGCTTTCACTGGGCGCTCCCT	0.478			NA											11	266					9.31168e-06	0.000203057	0.000151284	1	0
C20orf194	25943	broad.mit.edu	37	20	3303303	3303304	+	Nonsense_Mutation	DNP	CC	CC	AA			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr20:3303303_3303304CC>AA	uc002wii.2	-	15	1356_1357	c.1305_1306GG>TT	c.(1303-1308)CAGGGA>CATTGA	p.435_436QG>H*	C20orf194_uc002wij.3_Nonsense_Mutation_p.174_175QG>H*|C20orf194_uc002wik.2_Nonsense_Mutation_p.109_110QG>H*|C20orf194_uc010gay.1_RNA	NM_001009984	NP_001009984	Q5TEA3	CT194_HUMAN	hypothetical protein LOC25943	435_436											0						ACGCACCTTCCCTGATTATTCA	0.431			NA											13	394					0	0	6.4e-05	0	0
OTOR	56914	broad.mit.edu	37	20	16729075	16729076	+	Missense_Mutation	DNP	CG	CG	AT			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr20:16729075_16729076CG>AT	uc002wpj.2	+	1	73_74	c.29_30CG>AT	c.(28-30)CCG>CAT	p.P10H	OTOR_uc002wpk.2_5'Flank	NM_020157	NP_064542	Q9NRC9	OTOR_HUMAN	otoraplin precursor	10					sensory perception of sound	extracellular region				ovary(1)|central_nervous_system(1)	2						CTTTTCCTCCCGGGTCTTGTGG	0.431			NA											11	383					0	0	6.4e-05	0	0
PCSK2	5126	broad.mit.edu	37	20	17437055	17437055	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr20:17437055C>G	uc002wpm.2	+	10	1484	c.1164C>G	c.(1162-1164)CCC>CCG	p.P388P	PCSK2_uc002wpl.2_Silent_p.P369P|PCSK2_uc010zrm.1_Silent_p.P353P	NM_002594	NP_002585	P16519	NEC2_HUMAN	proprotein convertase subtilisin/kexin type 2	388	Catalytic.				enkephalin processing|insulin processing|islet amyloid polypeptide processing	extracellular space|membrane|soluble fraction|transport vesicle	serine-type endopeptidase activity			ovary(3)|central_nervous_system(2)|large_intestine(1)|pancreas(1)	7					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	CAGCTGCCCCCGAGGCAGCTG	0.532			NA											5	185					0	0	3.59834e-05	0	0
SSTR4	6754	broad.mit.edu	37	20	23016973	23016973	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr20:23016973G>A	uc002wsr.2	+	1	917	c.853G>A	c.(853-855)GTG>ATG	p.V285M		NM_001052	NP_001043	P31391	SSR4_HUMAN	somatostatin receptor 4	285	Extracellular (Potential).				G-protein signaling, coupled to cyclic nucleotide second messenger|negative regulation of cell proliferation	integral to plasma membrane	somatostatin receptor activity			ovary(1)	1	Colorectal(13;0.0518)|Lung NSC(19;0.0542)|all_lung(19;0.118)					GAACCTCTTCGTGACCAGCCT	0.552	Esophageal Squamous(15;850 1104 16640)		NA											51	87					0	0	0.000147903	0	0
CST9L	128821	broad.mit.edu	37	20	23549030	23549030	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr20:23549030C>A	uc002wtk.3	-	1	357	c.58G>T	c.(58-60)GGC>TGC	p.G20C		NM_080610	NP_542177	Q9H4G1	CST9L_HUMAN	cystatin 9-like precursor	20						extracellular region	cysteine-type endopeptidase inhibitor activity				0	Colorectal(13;0.0431)|Lung NSC(19;0.235)					ATCTGGGAGCCTAAGAGAAGC	0.582			NA											10	18					3.86212e-05	0.000822643	3.86212e-05	1	0
NINL	22981	broad.mit.edu	37	20	25456719	25456719	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr20:25456719G>C	uc002wux.1	-	17	3282	c.3208C>G	c.(3208-3210)CGG>GGG	p.R1070G	NINL_uc010gdn.1_Intron	NM_025176	NP_079452	Q9Y2I6	NINL_HUMAN	ninein-like	1070	Potential.				G2/M transition of mitotic cell cycle	cytosol|microtubule|microtubule organizing center	calcium ion binding			ovary(2)|pancreas(1)|central_nervous_system(1)|skin(1)	5						TCCAGAGCCCGGACGACGTCT	0.463			NA											4	122					0	0	3.59834e-05	0	0
ASXL1	171023	broad.mit.edu	37	20	31021635	31021635	+	Missense_Mutation	SNP	G	G	C	rs149449801		TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr20:31021635G>C	uc002wxs.2	+	11	2060	c.1634G>C	c.(1633-1635)CGT>CCT	p.R545P	ASXL1_uc010geb.2_Missense_Mutation_p.R436P	NM_015338	NP_056153	Q8IXJ9	ASXL1_HUMAN	additional sex combs like 1 isoform 1	545					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	PR-DUB complex	metal ion binding|protein binding			haematopoietic_and_lymphoid_tissue(239)|large_intestine(6)|central_nervous_system(2)|ovary(1)	248						CTTGAAGATCGTCAGTCCTTT	0.522			NA	F|N|Mis		MDS|CMML								45	68					0	0	0.000147903	0	0
NCOA6	23054	broad.mit.edu	37	20	33330374	33330374	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr20:33330374G>C	uc002xav.2	-	12	6257	c.3686C>G	c.(3685-3687)CCT>CGT	p.P1229R	NCOA6_uc002xaw.2_Missense_Mutation_p.P1229R	NM_014071	NP_054790	Q14686	NCOA6_HUMAN	nuclear receptor coactivator 6	1229	NCOA1-binding region.				brain development|cellular lipid metabolic process|DNA recombination|DNA repair|DNA replication|estrogen receptor signaling pathway|glucocorticoid receptor signaling pathway|heart development|myeloid cell differentiation|positive regulation of transcription from RNA polymerase II promoter|response to hormone stimulus|transcription initiation from RNA polymerase II promoter	transcription factor complex	chromatin binding|enzyme binding|estrogen receptor binding|ligand-dependent nuclear receptor transcription coactivator activity|retinoid X receptor binding|thyroid hormone receptor binding			ovary(3)|breast(3)|central_nervous_system(1)	7						TGTGCTGGGAGGGCGGTTGTT	0.512			NA											126	226					0	0	0.000147903	0	0
KIAA0406	9675	broad.mit.edu	37	20	36641045	36641045	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr20:36641045G>T	uc002xhl.2	-	3	1383	c.1174C>A	c.(1174-1176)CAA>AAA	p.Q392K	KIAA0406_uc002xhm.2_Missense_Mutation_p.Q392K	NM_014657	NP_055472	O43156	TTI1_HUMAN	hypothetical protein LOC9675	392							binding				0		Myeloproliferative disorder(115;0.00874)				TGGTCATCTTGGGAGTTCATT	0.463			NA											10	148					1.58986e-06	3.50024e-05	3.86212e-05	1	0
KIAA1755	85449	broad.mit.edu	37	20	36851966	36851966	+	Nonsense_Mutation	SNP	T	T	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr20:36851966T>A	uc002xhy.1	-	9	2514	c.2242A>T	c.(2242-2244)AAG>TAG	p.K748*	KIAA1755_uc002xhx.1_5'Flank	NM_001029864	NP_001025035	Q5JYT7	K1755_HUMAN	hypothetical protein LOC85449	748										ovary(4)|pancreas(1)	5		Myeloproliferative disorder(115;0.00874)				GGGTCGGCCTTCTCGAATTCC	0.607			NA											11	17					0	0	6.40141e-05	0	0
TNNC2	7125	broad.mit.edu	37	20	44453140	44453140	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr20:44453140C>T	uc002xpr.2	-	3	259	c.193G>A	c.(193-195)GAG>AAG	p.E65K		NM_003279	NP_003270	P02585	TNNC2_HUMAN	fast skeletal muscle troponin C	65	EF-hand 2.|2.				muscle filament sliding|regulation of muscle contraction|skeletal muscle contraction	cytosol|troponin complex	calcium ion binding			upper_aerodigestive_tract(1)	1		Myeloproliferative disorder(115;0.0122)				TCACCGTCCTCATCCACCTCC	0.672			NA											22	38					0	0	0.000375601	0	0
NCOA3	8202	broad.mit.edu	37	20	46265153	46265153	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr20:46265153G>T	uc002xtk.2	+	12	2228	c.2023G>T	c.(2023-2025)GGG>TGG	p.G675W	NCOA3_uc010ght.1_Missense_Mutation_p.G685W|NCOA3_uc002xtl.2_Missense_Mutation_p.G675W|NCOA3_uc002xtm.2_Missense_Mutation_p.G675W|NCOA3_uc002xtn.2_Missense_Mutation_p.G675W|NCOA3_uc010zyc.1_Missense_Mutation_p.G470W	NM_181659	NP_858045	Q9Y6Q9	NCOA3_HUMAN	nuclear receptor coactivator 3 isoform a	675					androgen receptor signaling pathway|cellular lipid metabolic process|positive regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleoplasm	androgen receptor binding|histone acetyltransferase activity|ligand-dependent nuclear receptor binding|protein N-terminus binding|signal transducer activity|thyroid hormone receptor binding			ovary(3)|lung(1)|skin(1)	5						CAATATGCATGGGTCACTGTT	0.473			NA											9	120					0.000442599	0.00887779	0.000442599	1	0
B4GALT5	9334	broad.mit.edu	37	20	48252857	48252857	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr20:48252857C>A	uc002xuu.3	-	9	1353	c.1159G>T	c.(1159-1161)GAG>TAG	p.E387*		NM_004776	NP_004767	O43286	B4GT5_HUMAN	UDP-Gal:betaGlcNAc beta 1,4-	387	Lumenal (Potential).				post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi cisterna membrane|integral to membrane	galactosyltransferase activity|metal ion binding			ovary(1)	1			BRCA - Breast invasive adenocarcinoma(9;2.51e-06)			TCTCAGTACTCGTTCACCTGA	0.483			NA											53	96					3.40165e-17	8.25516e-16	0.000147903	1	0
TSHZ2	128553	broad.mit.edu	37	20	51872086	51872086	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr20:51872086G>A	uc002xwo.2	+	2	3045	c.2089G>A	c.(2089-2091)GCC>ACC	p.A697T		NM_173485	NP_775756	Q9NRE2	TSH2_HUMAN	teashirt zinc finger homeobox 2	697					multicellular organismal development	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(5)|haematopoietic_and_lymphoid_tissue(1)	6			STAD - Stomach adenocarcinoma(23;0.1)			CCCACTCAGCGCCCTGCAGTC	0.612			NA											23	23					0	0	0.000375601	0	0
C20orf106	200232	broad.mit.edu	37	20	55100931	55100931	+	Silent	SNP	C	C	A	rs1054347		TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr20:55100931C>A	uc002xxx.2	+	2	401	c.321C>A	c.(319-321)CCC>CCA	p.P107P	GCNT7_uc010zzg.1_5'UTR|C20orf107_uc010zzh.1_Intron	NM_001012971	NP_001012989	Q5JX71	CT106_HUMAN	hypothetical protein LOC200232 precursor	107	Cytoplasmic (Potential).					integral to membrane					0			Colorectal(105;0.202)			ATGCTTCCCCCAACAAAGACT	0.453			NA											8	126					0.000157383	0.00327129	0.000157383	1	0
ZNF831	128611	broad.mit.edu	37	20	57766592	57766592	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr20:57766592C>G	uc002yan.2	+	1	518	c.518C>G	c.(517-519)CCG>CGG	p.P173R		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	173	C2H2-type 2.					intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					AGGCCCTTCCCGTGTGCCACC	0.607			NA											4	112					0	0	3.59834e-05	0	0
PPP1R3D	5509	broad.mit.edu	37	20	58514122	58514122	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr20:58514122C>G	uc002ybb.2	-	1	1231	c.865G>C	c.(865-867)GGG>CGG	p.G289R	C20orf177_uc002yba.2_Intron|C20orf177_uc010zzx.1_5'Flank|C20orf177_uc002ybc.2_5'Flank	NM_006242	NP_006233	O95685	PPR3D_HUMAN	protein phosphatase 1, regulatory subunit 3D	289					glycogen metabolic process		protein binding|protein serine/threonine phosphatase activity				0	all_lung(29;0.00391)		BRCA - Breast invasive adenocarcinoma(7;5.12e-09)			TCGCACTCCCCGCGAGGCATG	0.642			NA											3	37					0	0	0.00024832	0	0
ERG	2078	broad.mit.edu	37	21	39755518	39755518	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr21:39755518G>C	uc010gnw.2	-	12	1563	c.1268C>G	c.(1267-1269)CCG>CGG	p.P423R	ERG_uc002yxa.2_Missense_Mutation_p.P416R|ERG_uc011aek.1_Missense_Mutation_p.P324R|ERG_uc010gnv.2_Missense_Mutation_p.P300R|ERG_uc010gnx.2_Missense_Mutation_p.P399R|ERG_uc011ael.1_Missense_Mutation_p.P423R|ERG_uc002yxb.2_Missense_Mutation_p.P399R	NM_001136155	NP_001129627	P11308	ERG_HUMAN	ets-related isoform 4	423					cell proliferation|multicellular organismal development|protein phosphorylation	cytoplasm|nucleus|ribonucleoprotein complex	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|signal transducer activity		TMPRSS2/ERG(2499)|FUS/ERG(163)|EWSR1/ERG(162)	prostate(2499)|bone(167)|haematopoietic_and_lymphoid_tissue(153)|soft_tissue(5)|lung(2)|skin(1)|ovary(1)	2828		Prostate(19;3.6e-06)				GCCCATGTACGGGAGGTCTGA	0.612	Esophageal Squamous(130;336 1700 3010 3083 40589)		NA											3	41					0	0	6.4e-05	0	0
PRDM15	63977	broad.mit.edu	37	21	43222983	43222983	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr21:43222983C>G	uc002yzq.1	-	30	4041	c.3930G>C	c.(3928-3930)GCG>GCC	p.A1310A	PRDM15_uc002yzo.2_Silent_p.A981A|PRDM15_uc002yzp.2_Silent_p.A1001A|PRDM15_uc002yzr.1_Silent_p.A1001A	NM_022115	NP_071398	P57071	PRD15_HUMAN	PR domain containing 15 isoform 1	1310					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0						CCGGAGCACCCGCCTCCTCTT	0.577			NA											4	157					0	0	8.12818e-05	0	0
MED15	51586	broad.mit.edu	37	22	20921087	20921087	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr22:20921087C>A	uc002zsp.2	+	7	1104	c.1024C>A	c.(1024-1026)CAA>AAA	p.Q342K	MED15_uc002zso.2_Missense_Mutation_p.Q271K|MED15_uc002zsq.2_Missense_Mutation_p.Q342K|MED15_uc010gso.2_Missense_Mutation_p.Q342K|MED15_uc002zsr.2_Missense_Mutation_p.Q316K|MED15_uc011ahs.1_Missense_Mutation_p.Q316K|MED15_uc002zss.2_Missense_Mutation_p.Q261K|MED15_uc011ahu.1_Missense_Mutation_p.Q68K	NM_001003891	NP_001003891	Q96RN5	MED15_HUMAN	mediator complex subunit 15 isoform a	342	Pro-rich.				regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	Golgi apparatus|mediator complex	protein binding			skin(1)	1	all_cancers(11;2.07e-24)|Melanoma(16;0.000465)|Ovarian(15;0.00167)|Colorectal(54;0.0221)|all_neural(72;0.142)	Lung SC(17;0.0262)	LUSC - Lung squamous cell carcinoma(15;0.00102)|Lung(15;0.0173)|Epithelial(17;0.209)			GTTGTATACCCAACCACCACT	0.537			NA											6	52					8.12818e-05	0.00171015	8.12818e-05	1	0
MYO18B	84700	broad.mit.edu	37	22	26164827	26164827	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr22:26164827G>T	uc003abz.1	+	4	1194	c.944G>T	c.(943-945)GGG>GTG	p.G315V	MYO18B_uc003aca.1_Missense_Mutation_p.G196V|MYO18B_uc010guy.1_Missense_Mutation_p.G196V|MYO18B_uc010guz.1_Missense_Mutation_p.G196V|MYO18B_uc011aka.1_5'UTR|MYO18B_uc011akb.1_5'Flank	NM_032608	NP_115997	Q8IUG5	MY18B_HUMAN	myosin XVIIIB	315						nucleus|sarcomere|unconventional myosin complex	actin binding|ATP binding|motor activity			ovary(5)|central_nervous_system(3)|large_intestine(2)|breast(2)	12						CAAATCCCTGGGAGAAAGTGG	0.532			NA											4	4					1.23904e-05	0.000268915	1.23904e-05	1	0
SLC5A4	6527	broad.mit.edu	37	22	32650194	32650194	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr22:32650194G>T	uc003ami.2	-	2	144	c.142C>A	c.(142-144)CTG>ATG	p.L48M		NM_014227	NP_055042	Q9NY91	SC5A4_HUMAN	solute carrier family 5 (low affinity glucose	48	Extracellular (Potential).				carbohydrate transport|sodium ion transport	integral to membrane	symporter activity				0						TTGGTCTTCAGCATCGCCTGA	0.567			NA											33	15					1.90571e-15	4.55252e-14	0.000132358	1	0
TCF20	6942	broad.mit.edu	37	22	42575632	42575632	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr22:42575632G>C	uc003bcj.1	-	2	5866	c.5732C>G	c.(5731-5733)CCG>CGG	p.P1911R	TCF20_uc003bck.1_Missense_Mutation_p.P1911R|TCF20_uc003bnt.2_Missense_Mutation_p.P1911R	NM_005650	NP_005641	Q9UGU0	TCF20_HUMAN	transcription factor 20 isoform 1	1911	PHD-type; atypical.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|transcription coactivator activity|zinc ion binding			ovary(4)|skin(1)	5						AATGGCACACGGGTAATGGTA	0.502			NA											4	118					0	0	1.23904e-05	0	0
C22orf40	150383	broad.mit.edu	37	22	46641089	46641089	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr22:46641089C>G	uc003bhe.2	-	4	313	c.272G>C	c.(271-273)CGG>CCG	p.R91P	C22orf40_uc003bhc.2_3'UTR|C22orf40_uc003bhd.2_Missense_Mutation_p.R86P|C22orf40_uc003bhf.2_RNA	NM_207327	NP_997210	Q6NVV7	CV040_HUMAN	hypothetical protein LOC150383	91											0						GATGTTCTCCCGGACACAAGG	0.502			NA											4	38					0	0	1.23904e-05	0	0
CNTN4	152330	broad.mit.edu	37	3	2928832	2928832	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:2928832G>T	uc003bpc.2	+	9	1085	c.864G>T	c.(862-864)GAG>GAT	p.E288D	CNTN4_uc003bpb.1_Translation_Start_Site|CNTN4_uc003bpd.1_Missense_Mutation_p.E288D	NM_175607	NP_783200	Q8IWV2	CNTN4_HUMAN	contactin 4 isoform a precursor	288	Ig-like C2-type 3.				axon guidance|axonal fasciculation|brain development|negative regulation of neuron differentiation|neuron cell-cell adhesion|regulation of synaptic plasticity	anchored to membrane|axon|extracellular region|plasma membrane	protein binding			large_intestine(2)|ovary(2)|lung(1)|central_nervous_system(1)|pancreas(1)	7		Ovarian(110;0.156)		Epithelial(13;0.000695)|all cancers(10;0.0047)|OV - Ovarian serous cystadenocarcinoma(96;0.01)		TTCAGCAGGAGGATGCTGGTT	0.398			NA											26	37					5.45024e-15	1.29302e-13	0.00047179	1	0
GRM7	2917	broad.mit.edu	37	3	7620495	7620495	+	Silent	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:7620495G>T	uc003bqm.2	+	8	2176	c.1902G>T	c.(1900-1902)ACG>ACT	p.T634T	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Silent_p.T634T|GRM7_uc003bql.2_Silent_p.T634T|GRM7_uc003bqn.1_Silent_p.T217T|GRM7_uc010hch.1_Silent_p.T145T	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	634	Helical; Name=2; (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	TTCTTTTGACGGGCATCTTTC	0.498			NA											8	235					0.000157383	0.00327129	0.000157383	1	0
GRM7	2917	broad.mit.edu	37	3	7620936	7620936	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:7620936C>G	uc003bqm.2	+	8	2617	c.2343C>G	c.(2341-2343)CCC>CCG	p.P781P	GRM7_uc011ata.1_RNA|GRM7_uc011atb.1_RNA|GRM7_uc010hcf.2_RNA|GRM7_uc011atc.1_RNA|GRM7_uc010hcg.2_Silent_p.P781P|GRM7_uc003bql.2_Silent_p.P781P|GRM7_uc003bqn.1_Silent_p.P364P|GRM7_uc010hch.1_Silent_p.P292P	NM_000844	NP_000835	Q14831	GRM7_HUMAN	glutamate receptor, metabotropic 7 isoform a	781	Cytoplasmic (Potential).				negative regulation of adenylate cyclase activity|negative regulation of cAMP biosynthetic process|negative regulation of glutamate secretion|sensory perception of smell|sensory perception of sound|synaptic transmission	asymmetric synapse|axon|cell cortex|dendritic shaft|integral to plasma membrane|postsynaptic membrane|presynaptic active zone	adenylate cyclase inhibitor activity|calcium ion binding|glutamate binding|group III metabotropic glutamate receptor activity|PDZ domain binding|serine binding			ovary(4)|lung(3)	7					L-Glutamic Acid(DB00142)	GGGGTGTACCCGAGAATTTTA	0.428			NA											4	68					0	0	1.23904e-05	0	0
MKRN2	23609	broad.mit.edu	37	3	12623673	12623674	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:12623673_12623674CC>AA	uc003bxd.2	+	8	1228_1229	c.1172_1173CC>AA	c.(1171-1173)CCC>CAA	p.P391Q	MKRN2_uc003bxe.2_Missense_Mutation_p.P389Q|MKRN2_uc011aus.1_Missense_Mutation_p.P348Q	NM_014160	NP_054879	Q9H000	MKRN2_HUMAN	makorin ring finger protein 2	391						intracellular	ligase activity|nucleic acid binding|zinc ion binding				0						CGGCATGTCCCCAACAATGAAG	0.495			NA											9	248					0	0	6.4e-05	0	0
WNT7A	7476	broad.mit.edu	37	3	13896069	13896070	+	Missense_Mutation	DNP	CG	CG	AT			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:13896069_13896070CG>AT	uc003bye.1	-	3	834_835	c.529_530CG>AT	c.(529-531)CGG>ATG	p.R177M		NM_004625	NP_004616	O00755	WNT7A_HUMAN	wingless-type MMTV integration site family,	177					activation of JUN kinase activity|anterior/posterior pattern formation|canonical Wnt receptor signaling pathway|cell proliferation in forebrain|cellular response to transforming growth factor beta stimulus|central nervous system vasculogenesis|cerebellar granule cell differentiation|dorsal/ventral pattern formation|embryonic axis specification|embryonic digit morphogenesis|embryonic forelimb morphogenesis|embryonic leg morphogenesis|lens fiber cell development|negative regulation of neurogenesis|palate development|positive regulation of canonical Wnt receptor signaling pathway|positive regulation of epithelial cell proliferation involved in wound healing|positive regulation of JNK cascade|positive regulation of synaptogenesis|positive regulation of transcription from RNA polymerase II promoter|regulation of axon diameter|satellite cell activation|satellite cell maintenance involved in skeletal muscle regeneration|sex differentiation|uterus development|Wnt receptor signaling pathway involved in wound healing, spreading of epidermal cells|Wnt receptor signaling pathway, calcium modulating pathway	extracellular space|plasma membrane|proteinaceous extracellular matrix	cytokine activity|frizzled binding|receptor agonist activity|signal transducer activity			ovary(2)|breast(1)	3						CATGAGAGTCCGGGCATTCTGC	0.564			NA											7	248					0	0	6.4e-05	0	0
MRPS25	64432	broad.mit.edu	37	3	15094060	15094060	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:15094060C>G	uc003bzl.2	-	4	525	c.410G>C	c.(409-411)CGG>CCG	p.R137P	MRPS25_uc011avl.1_Missense_Mutation_p.G108R|MRPS25_uc011avm.1_Intron	NM_022497	NP_071942	P82663	RT25_HUMAN	mitochondrial ribosomal protein S25	137					translation	mitochondrial small ribosomal subunit	protein binding|structural constituent of ribosome				0						GATGCACTCCCGCAGGCAGTA	0.582			NA											5	234					0	0	8.12818e-05	0	0
OXSM	54995	broad.mit.edu	37	3	25833265	25833265	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:25833265C>G	uc003cdn.2	+	2	861	c.754C>G	c.(754-756)CGG>GGG	p.R252G	NGLY1_uc011awo.1_5'Flank|OXSM_uc011awp.1_5'UTR|OXSM_uc010hfh.2_Intron	NM_017897	NP_060367	Q9NWU1	OXSM_HUMAN	3-oxoacyl-ACP synthase, mitochondrial isoform 1	252					acyl-CoA metabolic process|medium-chain fatty acid biosynthetic process|short-chain fatty acid biosynthetic process	mitochondrion	3-oxoacyl-[acyl-carrier-protein] synthase activity			ovary(1)|breast(1)	2						TTCCAGAGCCCGGGCTCTGAG	0.478			NA											4	118					0	0	8.12818e-05	0	0
TRANK1	9881	broad.mit.edu	37	3	36873406	36873406	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:36873406C>G	uc003cgj.2	-	12	6188	c.5886G>C	c.(5884-5886)TCG>TCC	p.S1962S		NM_014831	NP_055646	O15050	TRNK1_HUMAN	lupus brain antigen 1	2512					DNA repair		ATP binding|ATP-dependent DNA helicase activity|DNA binding			ovary(1)|central_nervous_system(1)	2						CAGCCTCACCCGAGACCACAT	0.527			NA											5	97					0	0	3.59834e-05	0	0
ACVR2B	93	broad.mit.edu	37	3	38521287	38521287	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:38521287G>T	uc003cif.2	+	7	953	c.929G>T	c.(928-930)GGC>GTC	p.G310V	ACVR2B_uc003cig.2_Missense_Mutation_p.G101V	NM_001106	NP_001097	Q13705	AVR2B_HUMAN	activin A receptor, type IIB precursor	310	Cytoplasmic (Potential).|Protein kinase.				activin receptor signaling pathway|anterior/posterior pattern formation|BMP signaling pathway|positive regulation of activin receptor signaling pathway|positive regulation of bone mineralization|positive regulation of osteoblast differentiation|regulation of transcription, DNA-dependent	cell surface|cytoplasm|integral to plasma membrane	activin receptor activity|ATP binding|growth factor binding|metal ion binding|receptor signaling protein serine/threonine kinase activity|transforming growth factor beta receptor activity			lung(1)	1	Medulloblastoma(35;0.163)			KIRC - Kidney renal clear cell carcinoma(284;0.0565)|Kidney(284;0.071)		TGGTGCCGTGGCGAGGGCCAC	0.582			NA									OREG0015478	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	19	29					8.34094e-07	1.84817e-05	0.000132079	1	0
ZNF621	285268	broad.mit.edu	37	3	40574363	40574363	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:40574363G>T	uc003ckm.2	+	5	1318	c.1102G>T	c.(1102-1104)GTT>TTT	p.V368F	ZNF621_uc003ckn.2_Missense_Mutation_p.V368F|ZNF621_uc003cko.2_Missense_Mutation_p.V333F|ZNF621_uc011aze.1_Missense_Mutation_p.V360F	NM_001098414	NP_001091884	Q6ZSS3	ZN621_HUMAN	zinc finger protein 621	368					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1				KIRC - Kidney renal clear cell carcinoma(284;0.0515)|Kidney(284;0.0648)		catacctcctgttcttctcca	0.164			NA											9	6					0.000274275	0.00558288	0.000274275	1	0
CDCP1	64866	broad.mit.edu	37	3	45127529	45127529	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:45127529C>G	uc003com.2	-	9	2247	c.2112G>C	c.(2110-2112)GTG>GTC	p.V704V		NM_022842	NP_073753	Q9H5V8	CDCP1_HUMAN	CUB domain-containing protein 1 isoform 1	704	Cytoplasmic (Potential).					extracellular region|integral to membrane|plasma membrane				ovary(1)|central_nervous_system(1)|skin(1)	3				BRCA - Breast invasive adenocarcinoma(193;0.00928)|KIRC - Kidney renal clear cell carcinoma(197;0.0519)|Kidney(197;0.0651)		TGTAGATACCCACAGCGGGGC	0.448			NA											7	293					0	0	8.12818e-05	0	0
ATRIP	84126	broad.mit.edu	37	3	48502063	48502063	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:48502063C>G	uc003ctf.1	+	8	1642	c.1610C>G	c.(1609-1611)CCA>CGA	p.P537R	ATRIP_uc011bbj.1_Missense_Mutation_p.P410R|ATRIP_uc003ctg.1_Missense_Mutation_p.P537R|TREX1_uc010hjy.2_Intron	NM_130384	NP_569055	Q8WXE1	ATRIP_HUMAN	ATR interacting protein isoform 1	537					DNA damage checkpoint|DNA repair|DNA replication	nucleoplasm	protein binding|protein serine/threonine kinase activity			ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;0.000293)|KIRC - Kidney renal clear cell carcinoma(197;0.00558)|Kidney(197;0.00632)		GGACAGCACCCACTGTTGAAG	0.522			NA						Other_conserved_DNA_damage_response_genes					4	72					0	0	0.00024832	0	0
IP6K2	51447	broad.mit.edu	37	3	48725827	48725827	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:48725827G>A	uc003cup.2	-	6	1404	c.1160C>T	c.(1159-1161)ACC>ATC	p.T387I	NCKIPSD_uc003cum.2_5'Flank|NCKIPSD_uc003cun.2_5'Flank|NCKIPSD_uc010hkh.1_5'Flank|IP6K2_uc003cuq.2_Missense_Mutation_p.T387I	NM_001005909	NP_001005909	Q9UHH9	IP6K2_HUMAN	inositol hexaphosphate kinase 2 isoform a	387					negative regulation of cell growth|phosphatidylinositol phosphorylation|positive regulation of apoptosis|type I interferon-mediated signaling pathway	intermediate filament cytoskeleton|nucleus	ATP binding|inositol hexakisphosphate 5-kinase activity|inositol trisphosphate 3-kinase activity				0						CCTGCAGGTGGTGTGTGCAAA	0.552			NA											18	38					0	0	7.07596e-05	0	0
LAMB2	3913	broad.mit.edu	37	3	49168416	49168416	+	Silent	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:49168416G>C	uc003cwe.2	-	7	1181	c.882C>G	c.(880-882)CCC>CCG	p.P294P	LAMB2_uc003cwf.1_Silent_p.P294P	NM_002292	NP_002283	P55268	LAMB2_HUMAN	laminin, beta 2 precursor	294	Laminin EGF-like 1.				cell adhesion	laminin-11 complex|laminin-3 complex	structural molecule activity			ovary(3)	3				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.00219)|KIRC - Kidney renal clear cell carcinoma(197;0.00245)		CCCCTGGGGCGGGTGCACACT	0.612			NA											4	54					0	0	1.23904e-05	0	0
RBM6	10180	broad.mit.edu	37	3	50091820	50091820	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:50091820C>A	uc003cyc.2	+	8	1818	c.1685C>A	c.(1684-1686)CCA>CAA	p.P562Q	RBM6_uc011bdh.1_RNA|RBM6_uc010hlc.1_Missense_Mutation_p.P81Q|RBM6_uc003cyd.2_Missense_Mutation_p.P40Q|RBM6_uc003cye.2_Missense_Mutation_p.P40Q|RBM6_uc011bdi.1_5'UTR|RBM6_uc010hld.1_RNA|RBM6_uc010hle.1_RNA|RBM6_uc010hlf.1_RNA	NM_005777	NP_005768	P78332	RBM6_HUMAN	RNA binding motif protein 6	562					RNA processing	nucleus	DNA binding|nucleotide binding|RNA binding|zinc ion binding			ovary(2)	2				BRCA - Breast invasive adenocarcinoma(193;6.81e-05)|KIRC - Kidney renal clear cell carcinoma(197;0.0084)|Kidney(197;0.00977)		TGCAAGAACCCAAGAGAAGGT	0.383			NA											11	271					3.07112e-06	6.7398e-05	6.40141e-05	1	0
IQCF1	132141	broad.mit.edu	37	3	51937040	51937040	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:51937040C>T	uc003dbv.2	-	2	167	c.69G>A	c.(67-69)ATG>ATA	p.M23I	IQCF1_uc003dbq.3_RNA	NM_152397	NP_689610	Q8N6M8	IQCF1_HUMAN	IQ motif containing F1	23										ovary(1)	1				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000541)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		AATGGGTTGGCATCTCCTTCT	0.512			NA											255	406					0	0	0.000147903	0	0
PCBP4	57060	broad.mit.edu	37	3	51992957	51992957	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:51992957C>G	uc003dcd.1	-	11	1168	c.772G>C	c.(772-774)GGG>CGG	p.G258R	PCBP4_uc003dcb.1_Missense_Mutation_p.G224R|PCBP4_uc003dcc.1_Missense_Mutation_p.G279R|PCBP4_uc003dce.1_Missense_Mutation_p.R259P|PCBP4_uc003dcf.1_Missense_Mutation_p.G258R|PCBP4_uc003dcg.1_Missense_Mutation_p.G224R|PCBP4_uc003dch.1_Missense_Mutation_p.G258R|PCBP4_uc003dci.1_Missense_Mutation_p.G98R|PCBP4_uc003dcj.1_Missense_Mutation_p.G258R|PCBP4_uc003dck.1_Missense_Mutation_p.G215R|PCBP4_uc003dcl.1_Missense_Mutation_p.G258R	NM_033010	NP_127503	P57723	PCBP4_HUMAN	poly(rC) binding protein 4 isoform c	258	KH 3.					cytoplasm|ribonucleoprotein complex	DNA binding|RNA binding				0				BRCA - Breast invasive adenocarcinoma(193;8.01e-05)|Kidney(197;0.000534)|KIRC - Kidney renal clear cell carcinoma(197;0.000716)		CCCTGGCGCCCGATCACACAG	0.617			NA											4	99					0	0	1.23904e-05	0	0
STAB1	23166	broad.mit.edu	37	3	52537484	52537484	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:52537484G>C	uc003dej.2	+	8	893	c.819G>C	c.(817-819)AAG>AAC	p.K273N	STAB1_uc003dei.1_Missense_Mutation_p.K273N	NM_015136	NP_055951	Q9NY15	STAB1_HUMAN	stabilin 1 precursor	273	Extracellular (Potential).				cell adhesion|cell-cell signaling|defense response to bacterium|inflammatory response|negative regulation of angiogenesis|receptor-mediated endocytosis	integral to plasma membrane	bacterial cell surface binding|hyaluronic acid binding|low-density lipoprotein receptor activity|protein disulfide oxidoreductase activity|scavenger receptor activity			large_intestine(3)|upper_aerodigestive_tract(2)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	9				BRCA - Breast invasive adenocarcinoma(193;1.73e-05)|Kidney(197;0.00182)|KIRC - Kidney renal clear cell carcinoma(197;0.00205)|OV - Ovarian serous cystadenocarcinoma(275;0.0482)		GTCTGCCCAAGGACCCATGCA	0.622			NA											3	40					0	0	6.4e-05	0	0
CNTN3	5067	broad.mit.edu	37	3	74413646	74413646	+	Silent	SNP	A	A	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:74413646A>C	uc003dpm.1	-	9	1265	c.1185T>G	c.(1183-1185)GTT>GTG	p.V395V		NM_020872	NP_065923	Q9P232	CNTN3_HUMAN	contactin 3 precursor	395	Ig-like C2-type 4.				cell adhesion	anchored to membrane|plasma membrane	protein binding			breast(3)|ovary(1)|skin(1)	5		Lung NSC(201;0.138)|Lung SC(41;0.21)		Epithelial(33;0.00212)|BRCA - Breast invasive adenocarcinoma(55;0.00258)|LUSC - Lung squamous cell carcinoma(21;0.00461)|Lung(16;0.01)		CACTGGAATAAACAAGGCCAT	0.378			NA											21	43					0	0	0.000375601	0	0
ROBO2	6092	broad.mit.edu	37	3	77693982	77693982	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:77693982G>C	uc003dpy.3	+	25	4705	c.4062G>C	c.(4060-4062)CAG>CAC	p.Q1354H	ROBO2_uc003dpz.2_Missense_Mutation_p.Q1419H|ROBO2_uc011bgj.1_RNA|ROBO2_uc011bgk.1_Missense_Mutation_p.Q1358H	NM_002942	NP_002933	Q9HCK4	ROBO2_HUMAN	roundabout, axon guidance receptor, homolog 2	1354	Cytoplasmic (Potential).				apoptosis involved in luteolysis|axon midline choice point recognition|cellular response to hormone stimulus|homophilic cell adhesion|metanephros development|negative regulation of negative chemotaxis|negative regulation of synaptogenesis|olfactory bulb interneuron development|positive regulation of axonogenesis|retinal ganglion cell axon guidance|ureteric bud development	axolemma|cell surface|integral to membrane	axon guidance receptor activity|identical protein binding			lung(5)|skin(3)|ovary(1)|large_intestine(1)|liver(1)	11				Epithelial(33;0.00199)|LUSC - Lung squamous cell carcinoma(21;0.008)|BRCA - Breast invasive adenocarcinoma(55;0.00884)|Lung(72;0.0183)|KIRC - Kidney renal clear cell carcinoma(39;0.0832)|Kidney(39;0.103)		CAGGCCACCAGCGCAATGCCA	0.493			NA											50	66					0	0	0.000147903	0	0
GPR128	84873	broad.mit.edu	37	3	100362125	100362125	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:100362125G>C	uc003duc.2	+	7	982	c.714G>C	c.(712-714)ATG>ATC	p.M238I	GPR128_uc011bhc.1_Intron	NM_032787	NP_116176	Q96K78	GP128_HUMAN	G protein-coupled receptor 128 precursor	238	Extracellular (Potential).				neuropeptide signaling pathway	integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(3)|skin(1)	4						TTGAGCAAATGGAGACTTATT	0.363	Pancreas(87;185 1975 7223 18722)		NA											6	193					0	0	0.000157383	0	0
SENP7	57337	broad.mit.edu	37	3	101231956	101231956	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:101231956C>G	uc003dut.2	-	1	130	c.19G>C	c.(19-21)GGG>CGG	p.G7R	SENP7_uc003duu.2_Missense_Mutation_p.G7R|SENP7_uc003duv.2_5'UTR|SENP7_uc003duw.2_Missense_Mutation_p.G7R|SENP7_uc003dux.2_5'UTR	NM_020654	NP_065705	Q9BQF6	SENP7_HUMAN	sentrin/SUMO-specific protease 7 isoform 1	7					proteolysis	nucleus	cysteine-type peptidase activity			ovary(3)|lung(2)	5						GGCCGTCGCCCGAGCTTTCTC	0.602			NA											4	150					0	0	0.00024832	0	0
CEP97	79598	broad.mit.edu	37	3	101477064	101477064	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:101477064C>G	uc003dvk.1	+	9	1641	c.1614C>G	c.(1612-1614)CCC>CCG	p.P538P	CEP97_uc010hpm.1_Silent_p.P504P|CEP97_uc011bhf.1_Silent_p.P479P|CEP97_uc003dvl.1_Silent_p.P234P|CEP97_uc003dvm.1_Silent_p.P376P	NM_024548	NP_078824	Q8IW35	CEP97_HUMAN	centrosomal protein 97kDa	538	CEP110 binding.					centrosome|nucleus	protein binding			ovary(2)	2						AGAAACTTCCCATGATTTTAA	0.413			NA											5	207					0	0	1.23904e-05	0	0
C3orf15	89876	broad.mit.edu	37	3	119449158	119449158	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:119449158C>G	uc003ede.3	+	8	1029	c.952C>G	c.(952-954)CGG>GGG	p.R318G	C3orf15_uc010hqy.1_Missense_Mutation_p.R318G|C3orf15_uc010hqz.2_Missense_Mutation_p.R256G|C3orf15_uc011bjd.1_Missense_Mutation_p.R192G|C3orf15_uc011bje.1_Missense_Mutation_p.R298G|C3orf15_uc010hra.1_Missense_Mutation_p.R79G	NM_033364	NP_203528	Q7Z4T9	AAT1_HUMAN	AAT1-alpha	318						mitochondrion	protein binding			ovary(2)|pancreas(1)	3				GBM - Glioblastoma multiforme(114;0.186)		CTTGAATGCCCGGTGGTCTAA	0.438			NA											7	234					0	0	0.000157383	0	0
POLQ	10721	broad.mit.edu	37	3	121212468	121212468	+	Silent	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:121212468C>A	uc003eee.3	-	15	2508	c.2379G>T	c.(2377-2379)CTG>CTT	p.L793L	POLQ_uc003eed.2_5'Flank	NM_199420	NP_955452	O75417	DPOLQ_HUMAN	DNA polymerase theta	793					DNA repair|DNA replication	nucleoplasm	ATP binding|ATP-dependent helicase activity|damaged DNA binding|DNA-directed DNA polymerase activity|single-stranded DNA-dependent ATPase activity			ovary(4)|breast(3)|lung(2)|upper_aerodigestive_tract(1)|skin(1)	11				GBM - Glioblastoma multiforme(114;0.0915)		CCAGGTCACACAGCTCCCTCT	0.473	Pancreas(152;907 1925 26081 31236 36904)		NA						DNA_polymerases_(catalytic_subunits)					15	20					0.000308642	0.00625466	0.000308642	1	0
SLC15A2	6565	broad.mit.edu	37	3	121631924	121631925	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:121631924_121631925CC>AA	uc003eep.2	+	5	638_639	c.485_486CC>AA	c.(484-486)CCC>CAA	p.P162Q	SLC15A2_uc011bjn.1_Missense_Mutation_p.P131Q	NM_021082	NP_066568	Q16348	S15A2_HUMAN	peptide transporter 2 isoform a	162					protein transport	integral to plasma membrane	peptide:hydrogen symporter activity|protein binding			skin(1)	1				GBM - Glioblastoma multiforme(114;0.0967)	Cefadroxil(DB01140)	GGCATCAAACCCTGTGTGGCAG	0.416			NA											13	467					0	0	6.4e-05	0	0
MYLK	4638	broad.mit.edu	37	3	123452795	123452795	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:123452795C>A	uc003ego.2	-	10	1330	c.1048G>T	c.(1048-1050)GCA>TCA	p.A350S	MYLK_uc011bjw.1_Missense_Mutation_p.A350S|MYLK_uc003egp.2_Missense_Mutation_p.A350S|MYLK_uc003egq.2_Missense_Mutation_p.A350S|MYLK_uc003egr.2_Missense_Mutation_p.A350S|MYLK_uc003egs.2_Missense_Mutation_p.A174S	NM_053025	NP_444253	Q15746	MYLK_HUMAN	myosin light chain kinase isoform 1	350					aorta smooth muscle tissue morphogenesis|muscle contraction	cytosol	actin binding|ATP binding|calmodulin binding|metal ion binding|myosin light chain kinase activity			ovary(6)|skin(2)|stomach(1)	9		Lung NSC(201;0.0496)		GBM - Glioblastoma multiforme(114;0.0736)		TGAACTCTTGCGGCCTGCAGG	0.632			NA											39	76					7.53189e-24	1.90513e-22	0.000319135	1	0
UMPS	7372	broad.mit.edu	37	3	124449388	124449388	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:124449388G>T	uc003ehl.3	+	1	176	c.70G>T	c.(70-72)GGG>TGG	p.G24W	UMPS_uc003ehm.3_RNA|UMPS_uc011bka.1_5'UTR|UMPS_uc011bkb.1_5'UTR|UMPS_uc011bkc.1_5'UTR|UMPS_uc003ehn.3_5'UTR|UMPS_uc011bkd.1_5'UTR|hsa-mir-544b|MI0014159_5'Flank	NM_000373	NP_000364	P11172	UMPS_HUMAN	uridine monophosphate synthase	24	OPRTase.				'de novo' pyrimidine base biosynthetic process|'de novo' UMP biosynthetic process|pyrimidine nucleoside biosynthetic process	cytosol|nucleus	orotate phosphoribosyltransferase activity|orotidine-5'-phosphate decarboxylase activity			kidney(1)	1				GBM - Glioblastoma multiforme(114;0.146)		TTTCAAGTTTGGGGACTTCGT	0.592			NA											29	64					2.65835e-16	6.4061e-15	0.000184323	1	0
HEG1	57493	broad.mit.edu	37	3	124732073	124732073	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:124732073G>C	uc003ehs.3	-	6	2418	c.2350C>G	c.(2350-2352)CCA>GCA	p.P784A	HEG1_uc011bke.1_Missense_Mutation_p.P884A	NM_020733	NP_065784	Q9ULI3	HEG1_HUMAN	HEG homolog 1 precursor	784	Extracellular (Potential).					extracellular region|integral to membrane	calcium ion binding			ovary(2)	2						TCTTGGTGTGGGGTGCTCTGG	0.463			NA											5	264					0	0	3.59834e-05	0	0
COL29A1	256076	broad.mit.edu	37	3	130095223	130095223	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:130095223C>G	uc010htj.1	+	3	705	c.211C>G	c.(211-213)CTG>GTG	p.L71V	COL29A1_uc010hti.1_RNA	NM_153264	NP_694996	A8TX70	CO6A5_HUMAN	collagen, type XXIX, alpha 1	71	Nonhelical region.|VWFA 1.				axon guidance|cell adhesion	collagen					0						CCGTGTAGCCCTGGCCCAGTA	0.483			NA											3	33					0	0	0.00024832	0	0
PIK3R4	30849	broad.mit.edu	37	3	130463450	130463450	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:130463450C>A	uc003enj.2	-	2	1194	c.613G>T	c.(613-615)GGT>TGT	p.G205C		NM_014602	NP_055417	Q99570	PI3R4_HUMAN	phosphoinositide-3-kinase, regulatory subunit 4	205	Protein kinase.				fibroblast growth factor receptor signaling pathway|innate immune response|insulin receptor signaling pathway	cytosol	ATP binding|protein binding|protein serine/threonine kinase activity			ovary(3)|lung(2)|breast(2)|skin(2)|stomach(1)|central_nervous_system(1)|kidney(1)	12						AACATCCCACCATCAACAAAA	0.423			NA											20	39					2.54575e-18	6.24412e-17	0.000175454	1	0
NEK11	79858	broad.mit.edu	37	3	130828742	130828742	+	Silent	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:130828742G>C	uc003eny.2	+	5	758	c.432G>C	c.(430-432)CTG>CTC	p.L144L	NEK11_uc003enx.2_Silent_p.L144L|NEK11_uc003eoa.2_Silent_p.L144L|NEK11_uc003enz.2_5'UTR|NEK11_uc010htn.2_RNA|NEK11_uc011blk.1_5'UTR|NEK11_uc011bll.1_Silent_p.L144L|NEK11_uc003enw.1_Silent_p.L144L|NEK11_uc011blm.1_Silent_p.L144L|NEK11_uc010hto.1_5'UTR	NM_024800	NP_079076	Q8NG66	NEK11_HUMAN	NIMA-related kinase 11 isoform 1	144	Protein kinase.				cell cycle|intra-S DNA damage checkpoint|intracellular protein kinase cascade	nucleolus	ATP binding|identical protein binding|metal ion binding|protein serine/threonine kinase activity			large_intestine(4)|stomach(1)|central_nervous_system(1)	6						AGCTGCTGCTGGGAGTTGACT	0.363			NA											5	142					0	0	1.23904e-05	0	0
EPHB1	2047	broad.mit.edu	37	3	134885789	134885789	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:134885789G>C	uc003eqt.2	+	9	1920	c.1700G>C	c.(1699-1701)CGG>CCG	p.R567P	EPHB1_uc003equ.2_Missense_Mutation_p.R128P	NM_004441	NP_004432	P54762	EPHB1_HUMAN	ephrin receptor EphB1 precursor	567	Cytoplasmic (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity|protein binding			lung(11)|ovary(6)|stomach(4)|breast(3)|central_nervous_system(2)|skin(2)|large_intestine(1)|pancreas(1)	30						CACAGGAAACGGGCTTATAGC	0.567			NA											4	135					0	0	3.59834e-05	0	0
PCCB	5096	broad.mit.edu	37	3	135974715	135974715	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:135974715G>T	uc003eqy.1	+	2	252	c.201G>T	c.(199-201)AGG>AGT	p.R67S	PCCB_uc003eqz.1_Missense_Mutation_p.R67S|PCCB_uc011bmc.1_Missense_Mutation_p.R67S|PCCB_uc011bmd.1_5'UTR	NM_000532	NP_000523	P05166	PCCB_HUMAN	propionyl Coenzyme A carboxylase, beta	67	Carboxyltransferase.		R -> S (in PA-2).		fatty acid beta-oxidation	mitochondrial matrix	ATP binding|propionyl-CoA carboxylase activity				0					Biotin(DB00121)|L-Valine(DB00161)	TAACAGCCAGGGAGAGGATCA	0.463			NA											49	60					7.05377e-20	1.74883e-18	0.000147903	1	0
SUCNR1	56670	broad.mit.edu	37	3	151599205	151599205	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:151599205C>A	uc003ezf.1	+	3	973	c.874C>A	c.(874-876)CCT>ACT	p.P292T		NM_033050	NP_149039	Q9BXA5	SUCR1_HUMAN	succinate receptor 1	292	Helical; Name=7; (Potential).					integral to membrane|plasma membrane	purinergic nucleotide receptor activity, G-protein coupled			ovary(1)	1			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0813)		Succinic acid(DB00139)	TGTCATCAACCCTGTCTTCTA	0.463			NA											43	100					1.7489e-18	4.29731e-17	0.000106405	1	0
SI	6476	broad.mit.edu	37	3	164741477	164741477	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:164741477C>A	uc003fei.2	-	26	3042	c.2980G>T	c.(2980-2982)GGT>TGT	p.G994C		NM_001041	NP_001032	P14410	SUIS_HUMAN	sucrase-isomaltase	994	Lumenal.|Isomaltase.				carbohydrate metabolic process|polysaccharide digestion	apical plasma membrane|brush border|Golgi apparatus|integral to membrane	carbohydrate binding|oligo-1,6-glucosidase activity|sucrose alpha-glucosidase activity			ovary(7)|upper_aerodigestive_tract(4)|skin(2)|pancreas(1)	14		Prostate(884;0.00314)|Melanoma(1037;0.0153)|all_neural(597;0.0199)			Acarbose(DB00284)	GCTGTTATACCCATGGATGAA	0.403			NA								HNSCC(35;0.089)			27	46					9.04412e-07	2.00076e-05	9.22233e-05	1	0
KLHL6	89857	broad.mit.edu	37	3	183211960	183211960	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:183211960C>A	uc003flr.2	-	5	1315	c.1257G>T	c.(1255-1257)TTG>TTT	p.L419F	KLHL6_uc003fls.1_RNA|KLHL6_uc003flt.1_3'UTR|KLHL6_uc010hxk.1_RNA	NM_130446	NP_569713	Q8WZ60	KLHL6_HUMAN	kelch-like 6	419	Kelch 2.									haematopoietic_and_lymphoid_tissue(2)|ovary(1)	3	all_cancers(143;9.2e-12)|Ovarian(172;0.0172)		all cancers(12;1.29e-44)|Epithelial(37;1.24e-38)|LUSC - Lung squamous cell carcinoma(7;2.58e-24)|Lung(8;1.79e-22)|OV - Ovarian serous cystadenocarcinoma(80;2.32e-22)			CCTTGCCACCCAACACCACCA	0.448			NA											9	218					0.000274275	0.00558288	0.000274275	1	0
CHRD	8646	broad.mit.edu	37	3	184106428	184106429	+	Missense_Mutation	DNP	CG	CG	AT			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:184106428_184106429CG>AT	uc003fov.2	+	21	2854_2855	c.2608_2609CG>AT	c.(2608-2610)CGG>ATG	p.R870M	CHRD_uc003fow.2_Missense_Mutation_p.R500M|CHRD_uc003fox.2_Missense_Mutation_p.R870M|CHRD_uc003foy.2_Missense_Mutation_p.R500M|CHRD_uc010hyc.2_Missense_Mutation_p.R460M|CHRD_uc011brr.1_Missense_Mutation_p.R412M	NM_003741	NP_003732	Q9H2X0	CHRD_HUMAN	chordin precursor	870					BMP signaling pathway involved in spinal cord dorsal/ventral patterning|floor plate development|negative regulation of BMP signaling pathway|negative regulation of cell migration|positive regulation of cell adhesion|skeletal system development	extracellular space	cytokine binding			skin(2)|ovary(1)	3	all_cancers(143;6.33e-11)|Ovarian(172;0.0339)		Epithelial(37;4.96e-33)|OV - Ovarian serous cystadenocarcinoma(80;2.72e-22)			TGATGGGCCCCGGGGCTGCCGT	0.634			NA											8	87					0	0	6.4e-05	0	0
ATP13A5	344905	broad.mit.edu	37	3	192994553	192994553	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:192994553C>A	uc011bsq.1	-	29	3382	c.3382G>T	c.(3382-3384)GCT>TCT	p.A1128S		NM_198505	NP_940907	Q4VNC0	AT135_HUMAN	ATPase type 13A5	1128	Helical; (Potential).				ATP biosynthetic process|cation transport	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|metal ion binding			ovary(5)|skin(4)|large_intestine(2)	11	all_cancers(143;1.08e-08)|Ovarian(172;0.0386)		OV - Ovarian serous cystadenocarcinoma(49;5.56e-18)|LUSC - Lung squamous cell carcinoma(58;6.08e-06)|Lung(62;6.49e-06)	GBM - Glioblastoma multiforme(46;0.000307)		ACAAAGAAAGCCACACAGAAT	0.343			NA											14	50					4.14922e-12	9.67682e-11	0.000422831	1	0
GP5	2814	broad.mit.edu	37	3	194117476	194117476	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:194117476C>G	uc003ftv.1	-	2	1567	c.1536G>C	c.(1534-1536)ACG>ACC	p.T512T		NM_004488	NP_004479	P40197	GPV_HUMAN	glycoprotein V (platelet) precursor	512	Extracellular (Potential).				blood coagulation, intrinsic pathway|cell adhesion|platelet activation	integral to plasma membrane				skin(2)|breast(1)	3	all_cancers(143;6.64e-09)|Ovarian(172;0.0634)	Melanoma(1037;0.211)	OV - Ovarian serous cystadenocarcinoma(49;7.38e-18)|LUSC - Lung squamous cell carcinoma(58;3.55e-06)|Lung(62;4.19e-06)	GBM - Glioblastoma multiforme(46;4.06e-05)		GACCTTTGCCCGTGGTCACCG	0.507			NA											4	158					0	0	1.23904e-05	0	0
RNF168	165918	broad.mit.edu	37	3	196210747	196210748	+	Nonsense_Mutation	DNP	CC	CC	AA			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr3:196210747_196210748CC>AA	uc003fwq.2	-	4	1111_1112	c.573_574GG>TT	c.(571-576)GAGGGA>GATTGA	p.191_192EG>D*	RNF168_uc010iah.2_Nonsense_Mutation_p.24_25EG>D*	NM_152617	NP_689830	Q8IYW5	RN168_HUMAN	ring finger protein 168	191_192					double-strand break repair|histone H2A K63-linked ubiquitination|positive regulation of DNA repair|response to ionizing radiation	nucleus|ubiquitin ligase complex	chromatin binding|histone binding|ubiquitin binding|ubiquitin-protein ligase activity|zinc ion binding				0	all_cancers(143;1e-08)|Ovarian(172;0.0634)|Breast(254;0.206)		Epithelial(36;5.25e-24)|all cancers(36;5.47e-22)|OV - Ovarian serous cystadenocarcinoma(49;1.76e-18)|LUSC - Lung squamous cell carcinoma(58;1.51e-06)|Lung(62;1.95e-06)	GBM - Glioblastoma multiforme(46;0.00348)		GAGATACTTCCCTCACAGAAAT	0.332			NA											9	231					0	0	6.4e-05	0	0
CRIPAK	285464	broad.mit.edu	37	4	1389294	1389294	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr4:1389294G>T	uc003gdf.2	+	1	3955	c.995G>T	c.(994-996)TGC>TTC	p.C332F		NM_175918	NP_787114	Q8N1N5	CRPAK_HUMAN	cysteine-rich PAK1 inhibitor	332	9.				ER-nucleus signaling pathway|negative regulation of protein kinase activity|regulation of cytoskeleton organization|response to estrogen stimulus	endoplasmic reticulum|nucleus|plasma membrane	protein binding				0			OV - Ovarian serous cystadenocarcinoma(23;0.0106)			GTGCCCGCCTGCTCACACACA	0.672			NA											118	169					2.51586e-40	6.64458e-39	0.000147903	1	0
TMEM129	92305	broad.mit.edu	37	4	1719959	1719959	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr4:1719959C>G	uc003gdn.2	-	2	1120	c.600G>C	c.(598-600)TCG>TCC	p.S200S	TMEM129_uc010iby.2_RNA|TMEM129_uc003gdm.2_Silent_p.S200S	NM_001127266	NP_001120738	A0AVI4	TM129_HUMAN	transmembrane protein 129 isoform a	200	Extracellular (Potential).					integral to membrane					0			OV - Ovarian serous cystadenocarcinoma(23;0.00765)			TCGAGTCTGGCGAGAGCTCAT	0.607			NA											3	7					0	0	0.00024832	0	0
HTT	3064	broad.mit.edu	37	4	3134425	3134425	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr4:3134425G>C	uc011bvq.1	+	18	2524	c.2379G>C	c.(2377-2379)ATG>ATC	p.M793I		NM_002111	NP_002102	P42858	HD_HUMAN	huntingtin	791					establishment of mitotic spindle orientation|Golgi organization|retrograde vesicle-mediated transport, Golgi to ER|vesicle transport along microtubule	autophagic vacuole|axon|cytoplasmic vesicle membrane|cytosol|dendrite|endoplasmic reticulum|Golgi apparatus|late endosome|membrane fraction|nucleus|protein complex	beta-tubulin binding|dynactin binding|dynein intermediate chain binding|p53 binding|transcription factor binding			skin(2)|ovary(1)|lung(1)	4		all_epithelial(65;0.18)		UCEC - Uterine corpus endometrioid carcinoma (64;0.187)		GAGATTGGATGGGCACCATTA	0.488			NA											5	143					0	0	1.23904e-05	0	0
BOD1L	259282	broad.mit.edu	37	4	13605302	13605302	+	Silent	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr4:13605302C>T	uc003gmz.1	-	10	3339	c.3222G>A	c.(3220-3222)CGG>CGA	p.R1074R	BOD1L_uc010idr.1_Silent_p.R411R	NM_148894	NP_683692	Q8NFC6	BOD1L_HUMAN	biorientation of chromosomes in cell division	1074							DNA binding			ovary(5)|breast(1)	6						AGCTTCCTCTCCGATTTTCGC	0.418			NA											27	50					0	0	7.16444e-05	0	0
SEL1L3	23231	broad.mit.edu	37	4	25836822	25836823	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr4:25836822_25836823GG>TT	uc003gru.3	-	3	1008_1009	c.856_857CC>AA	c.(856-858)CCA>AAA	p.P286K		NM_015187	NP_056002	Q68CR1	SE1L3_HUMAN	sel-1 suppressor of lin-12-like 3	286						integral to membrane	binding				0						TCCTTACACTGGGTAATCCATC	0.525			NA											9	179					0	0	6.4e-05	0	0
WDR19	57728	broad.mit.edu	37	4	39219646	39219646	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr4:39219646G>C	uc003gtv.2	+	14	1554	c.1400G>C	c.(1399-1401)CGG>CCG	p.R467P	WDR19_uc003gtu.1_Missense_Mutation_p.G466R|WDR19_uc011byi.1_Missense_Mutation_p.R307P|WDR19_uc003gtw.1_Missense_Mutation_p.R64P	NM_025132	NP_079408	Q8NEZ3	WDR19_HUMAN	WD repeat domain 19	467					cell projection organization	microtubule basal body|motile cilium|photoreceptor connecting cilium	binding			large_intestine(1)	1						CGTGAGACTCGGCTTTTCCCA	0.373			NA											4	285					0	0	0.00024832	0	0
N4BP2	55728	broad.mit.edu	37	4	40104402	40104403	+	Missense_Mutation	DNP	CG	CG	AT	rs142821069		TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr4:40104402_40104403CG>AT	uc003guy.3	+	4	1275_1276	c.937_938CG>AT	c.(937-939)CGG>ATG	p.R313M	N4BP2_uc010ifq.2_Missense_Mutation_p.R233M|N4BP2_uc010ifr.2_Missense_Mutation_p.R233M	NM_018177	NP_060647	Q86UW6	N4BP2_HUMAN	Nedd4 binding protein 2	313						cytoplasm	ATP binding|ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity|endonuclease activity|protein binding			lung(3)|breast(2)|kidney(2)|ovary(1)	8						GAAATCTACTCGGGTCTCTGAT	0.485			NA											7	90					0	0	6.4e-05	0	0
GUF1	60558	broad.mit.edu	37	4	44693769	44693769	+	Silent	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr4:44693769G>T	uc003gww.3	+	13	1773	c.1566G>T	c.(1564-1566)GTG>GTT	p.V522V		NM_021927	NP_068746	Q8N442	GUF1_HUMAN	GUF1 GTPase homolog	522					translation	mitochondrial inner membrane	GTP binding|GTPase activity			upper_aerodigestive_tract(1)	1						ATGAAATTGTGGTAGATTTTT	0.313			NA											10	291					0.000442599	0.00887779	0.000442599	1	0
HOPX	84525	broad.mit.edu	37	4	57514950	57514950	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr4:57514950T>A	uc011cad.1	-	3	393	c.158A>T	c.(157-159)CAG>CTG	p.Q53L	HOPX_uc003hcc.2_3'UTR|HOPX_uc003hca.2_Missense_Mutation_p.Q71L|HOPX_uc003hcb.2_Missense_Mutation_p.Q53L|HOPX_uc003hcd.2_RNA|HOPX_uc003hce.2_RNA|HOPX_uc003hbz.2_Missense_Mutation_p.Q53L	NM_001145459	NP_001138931	Q9BPY8	HOP_HUMAN	HOP homeobox isoform b	53	Homeobox; atypical.				negative regulation of cell differentiation|trophectodermal cell differentiation	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity				0	Glioma(25;0.08)|all_neural(26;0.101)					TGCCAGGCGCTGCTTAAACCA	0.478			NA											45	46					0	0	0.000147903	0	0
CENPC1	1060	broad.mit.edu	37	4	68380143	68380143	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr4:68380143G>C	uc003hdd.1	-	8	1276	c.1093C>G	c.(1093-1095)CAT>GAT	p.H365D	CENPC1_uc010ihj.1_RNA|CENPC1_uc010ihk.1_RNA|CENPC1_uc010ihm.1_Missense_Mutation_p.H365D	NM_001812	NP_001803	Q03188	CENPC_HUMAN	centromere protein C 1	365					mitotic prometaphase	condensed chromosome kinetochore|condensed nuclear chromosome, centromeric region|cytosol	DNA binding			urinary_tract(1)|lung(1)	2						TGAGGTTTATGGGAATGTTTG	0.383			NA											5	60					0	0	1.23904e-05	0	0
PRKG2	5593	broad.mit.edu	37	4	82125807	82125808	+	Missense_Mutation	DNP	CG	CG	AT			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CG	CG	-	-	CG	CG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr4:82125807_82125808CG>AT	uc003hmh.2	-	1	408_409	c.394_395CG>AT	c.(394-396)CGG>ATG	p.R132M	PRKG2_uc011cch.1_Missense_Mutation_p.R132M	NM_006259	NP_006250	Q13237	KGP2_HUMAN	protein kinase, cGMP-dependent, type II	132					platelet activation|signal transduction	cytosol	ATP binding|cGMP binding|cGMP-dependent protein kinase activity			breast(3)|central_nervous_system(2)|ovary(1)|large_intestine(1)	7						GTCATAGGTCCGGGTTGTTGGC	0.495			NA											9	471					0	0	6.4e-05	0	0
C4orf21	55345	broad.mit.edu	37	4	113479457	113479457	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr4:113479457C>A	uc003iau.2	-	20	5180	c.4969G>T	c.(4969-4971)GGA>TGA	p.G1657*	C4orf21_uc003iav.2_RNA|C4orf21_uc003iat.2_Nonsense_Mutation_p.G115*	NM_018392	NP_060862	Q6ZU11	YD002_HUMAN	prematurely terminated mRNA decay factor-like	479						integral to membrane	zinc ion binding				0		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000676)		TTTCCTGCTCCAAACACACCT	0.274			NA											6	64					2.0095e-06	4.41704e-05	8.12818e-05	1	0
NDST3	9348	broad.mit.edu	37	4	119059263	119059263	+	Missense_Mutation	SNP	G	G	A	rs150758016	byFrequency	TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr4:119059263G>A	uc003ibx.2	+	5	1682	c.1279G>A	c.(1279-1281)GTC>ATC	p.V427I	NDST3_uc011cgf.1_Missense_Mutation_p.V346I	NM_004784	NP_004775	O95803	NDST3_HUMAN	N-deacetylase/N-sulfotransferase (heparan	427	Lumenal (Potential).|Heparan sulfate N-deacetylase 3.					Golgi membrane|integral to membrane	[heparan sulfate]-glucosamine N-sulfotransferase activity|hydrolase activity			large_intestine(1)	1						CCATTCGGGCGTCTACCCTGT	0.468			NA											31	58					0	0	0.000339439	0	0
CCNA2	890	broad.mit.edu	37	4	122742166	122742166	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr4:122742166C>T	uc003iec.3	-	3	843	c.538G>A	c.(538-540)GAG>AAG	p.E180K		NM_001237	NP_001228	P20248	CCNA2_HUMAN	cyclin A	180					cell division|mitosis|mitotic cell cycle G2/M transition DNA damage checkpoint|Ras protein signal transduction|regulation of cyclin-dependent protein kinase activity	cytoplasm|nucleoplasm	protein kinase binding			ovary(1)	1						TGAATATCCTCATGGTAGTCT	0.353			NA											41	108					0	0	0.000125731	0	0
KIAA1109	84162	broad.mit.edu	37	4	123167449	123167449	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr4:123167449C>A	uc003ieh.2	+	31	5225	c.5180C>A	c.(5179-5181)CCA>CAA	p.P1727Q	KIAA1109_uc003iek.2_Missense_Mutation_p.P346Q	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	1727					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						GTTAGCATACCAAAGGTAACa	0.328			NA											12	167					6.40141e-05	0.00135931	6.40141e-05	1	0
KIAA1109	84162	broad.mit.edu	37	4	123239424	123239424	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr4:123239424G>C	uc003ieh.2	+	61	10838	c.10793G>C	c.(10792-10794)CGG>CCG	p.R3598P	KIAA1109_uc003iel.1_Missense_Mutation_p.R1533P	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	3598					regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TCCAGTATGCGGGTGAGTTCT	0.318			NA											4	117					0	0	1.23904e-05	0	0
KIAA1109	84162	broad.mit.edu	37	4	123264572	123264572	+	Silent	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr4:123264572G>T	uc003ieh.2	+	71	12405	c.12360G>T	c.(12358-12360)TCG>TCT	p.S4120S	KIAA1109_uc003iem.2_Silent_p.S476S|KIAA1109_uc003ien.2_Silent_p.S54S	NM_015312	NP_056127	Q2LD37	K1109_HUMAN	fragile site-associated protein	4120	Ser-rich.				regulation of cell growth|regulation of epithelial cell differentiation	integral to membrane|nucleus				ovary(8)|skin(2)|pancreas(1)|central_nervous_system(1)	12						TAGGTTCATCGGGATTAGGCA	0.433			NA											5	86					8.12818e-05	0.00171015	8.12818e-05	1	0
HSPA4L	22824	broad.mit.edu	37	4	128753935	128753935	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr4:128753935C>A	uc003ifm.2	+	19	2679	c.2426C>A	c.(2425-2427)CCA>CAA	p.P809Q	HSPA4L_uc011cgr.1_Missense_Mutation_p.P776Q	NM_014278	NP_055093	O95757	HS74L_HUMAN	heat shock 70kDa protein 4-like	809					protein folding|response to unfolded protein	cytoplasm|nucleus	ATP binding|protein binding			ovary(2)|central_nervous_system(1)|skin(1)	4						CACAATGGCCCAATGGATGGA	0.403			NA											8	113					0.000157383	0.00327129	0.000157383	1	0
SCLT1	132320	broad.mit.edu	37	4	129886409	129886409	+	Missense_Mutation	SNP	T	T	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr4:129886409T>G	uc003igp.2	-	11	1348	c.842A>C	c.(841-843)CAG>CCG	p.Q281P	SCLT1_uc003ign.2_Intron|SCLT1_uc003igo.2_5'UTR|SCLT1_uc003igq.2_Intron|SCLT1_uc010iob.1_Intron	NM_144643	NP_653244	Q96NL6	SCLT1_HUMAN	sodium channel associated protein 1	281	Potential.					centrosome				ovary(3)|lung(1)|central_nervous_system(1)	5						TATACTAGACTGTAACTGCTG	0.343			NA											22	81					0	0	9.22233e-05	0	0
TBC1D9	23158	broad.mit.edu	37	4	141543675	141543675	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr4:141543675C>G	uc010ioj.2	-	21	3747	c.3475G>C	c.(3475-3477)GAC>CAC	p.D1159H		NM_015130	NP_055945	Q6ZT07	TBCD9_HUMAN	TBC1 domain family, member 9 (with GRAM domain)	1159						intracellular	calcium ion binding|Rab GTPase activator activity			ovary(1)	1	all_hematologic(180;0.162)	Medulloblastoma(177;0.00498)				ATGGAGCTGTCGTCCTTGGTG	0.622			NA											36	49					0	0	0.000270559	0	0
USP38	84640	broad.mit.edu	37	4	144135082	144135082	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr4:144135082C>G	uc003ijb.2	+	9	2487	c.1953C>G	c.(1951-1953)CCC>CCG	p.P651P	USP38_uc003ija.3_Silent_p.P651P|USP38_uc003ijc.2_RNA	NM_032557	NP_115946	Q8NB14	UBP38_HUMAN	ubiquitin specific peptidase 38	651					ubiquitin-dependent protein catabolic process		cysteine-type peptidase activity|ubiquitin thiolesterase activity			lung(2)|ovary(1)|breast(1)|pancreas(1)	5	all_hematologic(180;0.158)					CCTCTGTACCCGGTCCTTCAG	0.438			NA											7	261					0	0	0.000274275	0	0
ANAPC10	10393	broad.mit.edu	37	4	145916629	145916629	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr4:145916629G>C	uc003iju.3	-	6	609	c.454C>G	c.(454-456)CAT>GAT	p.H152D	ANAPC10_uc003ijv.3_Missense_Mutation_p.H152D|ANAPC10_uc003ijw.3_Missense_Mutation_p.H152D	NM_014885	NP_055700	Q9UM13	APC10_HUMAN	anaphase promoting complex subunit 10	152	DOC.				anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process|cell division|G2/M transition of mitotic cell cycle|mitotic anaphase|mitotic cell cycle spindle assembly checkpoint|negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle|protein K11-linked ubiquitination	anaphase-promoting complex|cytosol|nucleoplasm	ubiquitin-protein ligase activity				0	all_hematologic(180;0.151)					TGTCTCATATGGGTGTCTCTT	0.368			NA											5	216					0	0	3.59834e-05	0	0
ABCE1	6059	broad.mit.edu	37	4	146044398	146044398	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr4:146044398G>C	uc003ijx.2	+	15	1846	c.1406G>C	c.(1405-1407)CGA>CCA	p.R469P	ABCE1_uc003ijy.2_Missense_Mutation_p.R469P|ABCE1_uc010iot.2_RNA	NM_001040876	NP_001035809	P61221	ABCE1_HUMAN	ATP-binding cassette, sub-family E, member 1	469	ABC transporter 2.				interspecies interaction between organisms|response to virus|RNA catabolic process	mitochondrion	ATP binding|ATPase activity|electron carrier activity|iron-sulfur cluster binding|ribonuclease inhibitor activity			skin(1)	1	all_hematologic(180;0.151)					GAACTACAGCGAGTAGCTTTA	0.378			NA											4	99					0	0	1.23904e-05	0	0
DCHS2	54798	broad.mit.edu	37	4	155241831	155241831	+	Missense_Mutation	SNP	G	G	C	rs139445399		TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr4:155241831G>C	uc003inw.2	-	14	3355	c.3355C>G	c.(3355-3357)CGT>GGT	p.R1119G		NM_017639	NP_060109	Q6V1P9	PCD23_HUMAN	dachsous 2 isoform 1	1119	Cadherin 9.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding			ovary(3)|pancreas(1)	4	all_hematologic(180;0.208)	Renal(120;0.0854)		LUSC - Lung squamous cell carcinoma(193;0.107)		CTGTCAAGACGGGACACAGTG	0.463			NA											6	255					0	0	8.12818e-05	0	0
PLRG1	5356	broad.mit.edu	37	4	155468953	155468953	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr4:155468953G>T	uc003iny.2	-	3	232	c.169C>A	c.(169-171)CAT>AAT	p.H57N	PLRG1_uc003inz.2_Missense_Mutation_p.H57N|PLRG1_uc011cil.1_5'UTR	NM_002669	NP_002660	O43660	PLRG1_HUMAN	pleiotropic regulator 1 (PRL1 homolog,	57						catalytic step 2 spliceosome|nuclear speck	protein binding|signal transducer activity|transcription corepressor activity				0	all_hematologic(180;0.215)	Renal(120;0.0854)				GTAGGCATATGCAACACAGGA	0.348			NA											25	52					8.24728e-16	1.97705e-14	9.22233e-05	1	0
GUCY1B3	2983	broad.mit.edu	37	4	156715060	156715060	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr4:156715060A>T	uc003ipc.2	+	6	715	c.548A>T	c.(547-549)GAA>GTA	p.E183V	GUCY1B3_uc011cio.1_Missense_Mutation_p.E205V|GUCY1B3_uc011cip.1_Missense_Mutation_p.E163V|GUCY1B3_uc003ipd.2_Missense_Mutation_p.E111V|GUCY1B3_uc010iqf.2_Missense_Mutation_p.E183V|GUCY1B3_uc010iqg.2_Missense_Mutation_p.E111V|GUCY1B3_uc011ciq.1_Missense_Mutation_p.E111V	NM_000857	NP_000848	Q02153	GCYB1_HUMAN	guanylate cyclase 1, soluble, beta 3	183					blood circulation|intracellular signal transduction|nitric oxide mediated signal transduction|platelet activation	guanylate cyclase complex, soluble|intracellular membrane-bounded organelle	GTP binding|guanylate cyclase activity|receptor activity				0	all_hematologic(180;0.24)	Renal(120;0.0854)		COAD - Colon adenocarcinoma(41;0.148)		TTAATTGAAGAAAAAGAGTCA	0.343			NA											47	91					0	0	0.000147903	0	0
SH3RF1	57630	broad.mit.edu	37	4	170190190	170190190	+	Silent	SNP	C	C	G	rs141769951		TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr4:170190190C>G	uc003isa.1	-	2	509	c.174G>C	c.(172-174)TCG>TCC	p.S58S		NM_020870	NP_065921	Q7Z6J0	SH3R1_HUMAN	SH3 domain containing ring finger 1	58						Golgi apparatus|lamellipodium|perinuclear region of cytoplasm	ligase activity|zinc ion binding			breast(2)|lung(1)	3		Prostate(90;0.00267)|Renal(120;0.0183)		GBM - Glioblastoma multiforme(119;0.0287)		CCTCGACACCCGAGCCAACAA	0.537			NA											3	50					0	0	6.4e-05	0	0
GALNT7	51809	broad.mit.edu	37	4	174223255	174223255	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr4:174223255G>T	uc003isz.3	+	7	1289	c.1206G>T	c.(1204-1206)TTG>TTT	p.L402F	GALNT7_uc011ckb.1_Missense_Mutation_p.L179F	NM_017423	NP_059119	Q86SF2	GALT7_HUMAN	polypeptide N-acetylgalactosaminyltransferase 7	402	Catalytic subdomain B.|Lumenal (Potential).				protein O-linked glycosylation	Golgi membrane|integral to membrane	polypeptide N-acetylgalactosaminyltransferase activity|sugar binding			central_nervous_system(1)	1		Prostate(90;0.0132)|Renal(120;0.0183)|Melanoma(52;0.0749)|all_hematologic(60;0.107)|all_neural(102;0.122)		all cancers(43;1.87e-18)|Epithelial(43;3.44e-17)|OV - Ovarian serous cystadenocarcinoma(60;2.48e-09)|STAD - Stomach adenocarcinoma(60;0.0019)|GBM - Glioblastoma multiforme(59;0.0119)|LUSC - Lung squamous cell carcinoma(193;0.0199)		TCTTTGAATTGGGTCTCTATG	0.418			NA											11	215					0.000308642	0.00625466	0.000308642	1	0
F11	2160	broad.mit.edu	37	4	187209638	187209638	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr4:187209638A>T	uc003iza.1	+	15	2081	c.1748A>T	c.(1747-1749)CAC>CTC	p.H583L	uc003izb.1_RNA	NM_000128	NP_000119	P03951	FA11_HUMAN	coagulation factor XI precursor	583	Peptidase S1.				blood coagulation, intrinsic pathway|plasminogen activation|positive regulation of fibrinolysis	extracellular space|plasma membrane	heparin binding|serine-type endopeptidase activity				0		all_cancers(14;6.2e-52)|all_epithelial(14;1.62e-38)|all_lung(41;1.34e-13)|Lung NSC(41;3.58e-13)|Melanoma(20;1.91e-06)|Hepatocellular(41;0.00886)|Renal(120;0.00988)|Prostate(90;0.00996)|all_hematologic(60;0.014)|Colorectal(36;0.0161)|all_neural(102;0.202)		OV - Ovarian serous cystadenocarcinoma(60;2.13e-11)|BRCA - Breast invasive adenocarcinoma(30;4.59e-06)|GBM - Glioblastoma multiforme(59;0.000149)|STAD - Stomach adenocarcinoma(60;0.000314)|LUSC - Lung squamous cell carcinoma(40;0.00112)|READ - Rectum adenocarcinoma(43;0.176)	Coagulation Factor IX(DB00100)	TCCTGCAAACACAATGAGGTC	0.557			NA											70	115					0	0	0.000147903	0	0
FAT1	2195	broad.mit.edu	37	4	187630249	187630249	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr4:187630249C>T	uc003izf.2	-	2	921	c.733G>A	c.(733-735)GTG>ATG	p.V245M	FAT1_uc010iso.1_Missense_Mutation_p.V245M	NM_005245	NP_005236	Q14517	FAT1_HUMAN	FAT tumor suppressor 1 precursor	245	Extracellular (Potential).|Cadherin 2.				actin filament organization|anatomical structure morphogenesis|cell migration|cell-cell signaling|establishment or maintenance of cell polarity|homophilic cell adhesion	cell-cell junction|integral to plasma membrane|nucleus|perinuclear region of cytoplasm	calcium ion binding|protein binding			ovary(10)|central_nervous_system(1)|pancreas(1)	12						TCGATGTGCACCGTTAGCTTG	0.512	Colon(197;1040 2055 4143 4984 49344)		NA								HNSCC(5;0.00058)			54	84					0	0	0.000147903	0	0
TRIML2	205860	broad.mit.edu	37	4	189012726	189012726	+	Missense_Mutation	SNP	A	A	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr4:189012726A>T	uc003izl.2	-	7	1001	c.965T>A	c.(964-966)GTT>GAT	p.V322D	TRIML2_uc003izj.1_Missense_Mutation_p.V150D|TRIML2_uc003izk.1_Missense_Mutation_p.V130D|TRIML2_uc011cle.1_Missense_Mutation_p.V397D	NM_173553	NP_775824	Q8N7C3	TRIMM_HUMAN	tripartite motif family-like 2	322	B30.2/SPRY.						ligase activity			central_nervous_system(2)	2		all_cancers(14;3.11e-44)|all_epithelial(14;7.86e-31)|all_lung(41;4.3e-13)|Lung NSC(41;9.69e-13)|Melanoma(20;7.86e-05)|Breast(6;0.000148)|all_hematologic(60;0.0202)|Hepatocellular(41;0.0218)|Renal(120;0.0376)|Prostate(90;0.0513)		OV - Ovarian serous cystadenocarcinoma(60;1.79e-11)|BRCA - Breast invasive adenocarcinoma(30;4.52e-06)|GBM - Glioblastoma multiforme(59;1.62e-05)|STAD - Stomach adenocarcinoma(60;0.000279)|LUSC - Lung squamous cell carcinoma(40;0.0091)|READ - Rectum adenocarcinoma(43;0.163)		GTCAAGGAAAACGCCAACTGT	0.527			NA											68	140					0	0	0.000147903	0	0
CEP72	55722	broad.mit.edu	37	5	640629	640629	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr5:640629C>G	uc003jbf.2	+	9	1521	c.1449C>G	c.(1447-1449)TCC>TCG	p.S483S		NM_018140	NP_060610	Q9P209	CEP72_HUMAN	centrosomal protein 72 kDa	483	Potential.				G2/M transition of mitotic cell cycle|gamma-tubulin complex localization|spindle organization	centrosome|cytosol				ovary(1)	1			Epithelial(17;0.000339)|all cancers(22;0.00137)|OV - Ovarian serous cystadenocarcinoma(19;0.00153)|Lung(60;0.0863)			AGAGTAAGTCCCTGCAAAGCC	0.597			NA											5	141					0	0	3.59834e-05	0	0
KIAA0947	23379	broad.mit.edu	37	5	5464767	5464767	+	Nonsense_Mutation	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr5:5464767C>T	uc003jdm.3	+	13	5542	c.5320C>T	c.(5320-5322)CAA>TAA	p.Q1774*		NM_015325	NP_056140	Q9Y2F5	K0947_HUMAN	hypothetical protein LOC23379	1774										ovary(1)|central_nervous_system(1)	2						AGGGAATATTCAACTCACACG	0.493			NA											13	22					0	0	0.00010058	0	0
NSUN2	54888	broad.mit.edu	37	5	6602608	6602609	+	Nonsense_Mutation	DNP	CC	CC	AA			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr5:6602608_6602609CC>AA	uc003jdu.2	-	18	2027_2028	c.1962_1963GG>TT	c.(1960-1965)AAGGGA>AATTGA	p.654_655KG>N*	NSUN2_uc003jds.2_Nonsense_Mutation_p.100_101KG>N*|NSUN2_uc003jdt.2_Nonsense_Mutation_p.418_419KG>N*|NSUN2_uc011cmk.1_Nonsense_Mutation_p.619_620KG>N*|NSUN2_uc003jdv.2_Nonsense_Mutation_p.418_419KG>N*	NM_017755	NP_060225	Q08J23	NSUN2_HUMAN	NOL1/NOP2/Sun domain family, member 2	654_655						cytoplasm|nucleolus	tRNA (cytosine-5-)-methyltransferase activity|tRNA binding			ovary(1)	1						ACGATGCTTCCCTTTGCTGGAA	0.475			NA											11	451					0	0	6.4e-05	0	0
ZNF622	90441	broad.mit.edu	37	5	16463331	16463332	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr5:16463331_16463332CC>AA	uc003jfq.2	-	3	1054_1055	c.934_935GG>TT	c.(934-936)GGG>TTG	p.G312L		NM_033414	NP_219482	Q969S3	ZN622_HUMAN	zinc finger protein 622	312						cytoplasm|nucleus	nucleic acid binding|zinc ion binding			ovary(1)	1						GAAGGACTTCCCTTTCTCGTTG	0.401			NA											17	617					0	0	6.4e-05	0	0
C5orf22	55322	broad.mit.edu	37	5	31545771	31545772	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr5:31545771_31545772CC>AA	uc003jhj.3	+	7	1138_1139	c.1011_1012CC>AA	c.(1009-1014)CCCCTT>CCAATT	p.L338I	C5orf22_uc011cnw.1_RNA|C5orf22_uc003jhk.3_Missense_Mutation_p.L73I|C5orf22_uc010iuj.2_Missense_Mutation_p.L7I	NM_018356	NP_060826	Q49AR2	CE022_HUMAN	hypothetical protein LOC55322	338								p.L338F(1)		ovary(2)	2						CACTAGTTCCCCTTGTACAGAG	0.312			NA											12	429					0	0	6.4e-05	0	0
SPEF2	79925	broad.mit.edu	37	5	35800155	35800155	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr5:35800155C>G	uc003jjo.2	+	34	5027	c.4916C>G	c.(4915-4917)CCA>CGA	p.P1639R	SPEF2_uc003jjp.1_Missense_Mutation_p.P1125R|SPEF2_uc003jjr.2_Missense_Mutation_p.P694R	NM_024867	NP_079143	Q9C093	SPEF2_HUMAN	KPL2 protein isoform 1	1639					nucleobase, nucleoside, nucleotide and nucleic acid metabolic process		ATP binding|nucleobase, nucleoside, nucleotide kinase activity|protein dimerization activity			skin(2)|ovary(1)|central_nervous_system(1)	4	all_lung(31;7.56e-05)		Lung(74;0.111)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)			GCTTGCCACCCAGACACCGTG	0.463			NA											8	291					0	0	0.000157383	0	0
SLC1A3	6507	broad.mit.edu	37	5	36608612	36608612	+	Silent	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr5:36608612C>A	uc003jkj.3	+	2	563	c.87C>A	c.(85-87)GCC>GCA	p.A29A	SLC1A3_uc011cox.1_5'UTR|SLC1A3_uc010iuy.2_Silent_p.A29A	NM_004172	NP_004163	P43003	EAA1_HUMAN	solute carrier family 1 (glial high affinity	29	Cytoplasmic (Potential).				D-aspartate import|L-glutamate import|neurotransmitter uptake	integral to membrane|membrane fraction	high-affinity glutamate transmembrane transporter activity|sodium:dicarboxylate symporter activity				0	all_lung(31;0.000245)		Epithelial(62;0.0444)|Lung(74;0.111)|all cancers(62;0.128)|COAD - Colon adenocarcinoma(61;0.14)|Colorectal(62;0.202)		L-Glutamic Acid(DB00142)	CACTTTTGGCCAAGAAGAAAG	0.453			NA											79	301					2.72187e-29	7.05328e-28	0.000147903	1	0
FYB	2533	broad.mit.edu	37	5	39202308	39202308	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr5:39202308C>G	uc003jls.2	-	1	822	c.755G>C	c.(754-756)GGG>GCG	p.G252A	FYB_uc003jlt.2_Missense_Mutation_p.G252A|FYB_uc003jlu.2_Missense_Mutation_p.G252A|FYB_uc011cpl.1_Missense_Mutation_p.G262A	NM_199335	NP_955367	O15117	FYB_HUMAN	FYN binding protein (FYB-120/130) isoform 2	252					cell junction assembly|immune response|intracellular protein kinase cascade|NLS-bearing substrate import into nucleus|protein phosphorylation|T cell receptor signaling pathway	cytosol|nucleus	protein binding			ovary(2)	2	all_lung(31;0.000343)		Epithelial(62;0.235)			TGAAATCTCCCCTGCATGGTC	0.498			NA											6	347					0	0	8.12818e-05	0	0
FBXO4	26272	broad.mit.edu	37	5	41939605	41939605	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr5:41939605T>C	uc003jmq.2	+	6	1017	c.961T>C	c.(961-963)TCG>CCG	p.S321P	FBXO4_uc003jmr.2_Intron	NM_012176	NP_036308	Q9UKT5	FBX4_HUMAN	F-box only protein 4 isoform 1	321					positive regulation of protein ubiquitination|protein polyubiquitination|SCF-dependent proteasomal ubiquitin-dependent protein catabolic process|telomere maintenance|ubiquitin-dependent protein catabolic process	cytoplasm|SCF ubiquitin ligase complex	protein binding|protein homodimerization activity|ubiquitin-protein ligase activity			liver(1)	1		Lung NSC(810;4.15e-05)|Breast(839;0.00093)|Ovarian(839;0.00965)|Myeloproliferative disorder(839;0.0255)|all_neural(839;0.0604)				CTTTGGGTCTTCGGGAAGACC	0.373			NA											251	127					0	0	0.000147903	0	0
TMEM167A	153339	broad.mit.edu	37	5	82360853	82360853	+	Silent	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr5:82360853G>C	uc003khx.3	-	2	217	c.87C>G	c.(85-87)CCC>CCG	p.P29P	SCARNA18_uc003khz.2_5'Flank	NM_174909	NP_777569	Q8TBQ9	KISHA_HUMAN	transmembrane protein 167A precursor	29	Extracellular (Potential).					Golgi membrane|integral to membrane					0						CCAGGAGGCTGGGTGCCAAGG	0.323			NA											5	122					0	0	8.12818e-05	0	0
TRIM36	55521	broad.mit.edu	37	5	114499299	114499299	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr5:114499299C>G	uc003kqs.2	-	2	723	c.214G>C	c.(214-216)GGA>CGA	p.G72R	TRIM36_uc011cwc.1_Missense_Mutation_p.G60R|TRIM36_uc003kqt.2_Intron	NM_018700	NP_061170	Q9NQ86	TRI36_HUMAN	tripartite motif-containing 36 isoform 1	72	RING-type; degenerate.					acrosomal vesicle|cytoskeleton	ligase activity|zinc ion binding			ovary(4)|lung(2)|breast(2)	8		all_cancers(142;0.00133)|all_epithelial(76;2.41e-05)|Prostate(80;0.00955)|Ovarian(225;0.0443)|Breast(839;0.195)		OV - Ovarian serous cystadenocarcinoma(64;3.62e-08)|Epithelial(69;7.69e-08)|all cancers(49;9.33e-06)		TTGTCTGATCCCACATCGTTG	0.443			NA											4	56					0	0	0.00024832	0	0
FBN2	2201	broad.mit.edu	37	5	127595291	127595291	+	Silent	SNP	G	G	T	rs137914321		TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr5:127595291G>T	uc003kuu.2	-	65	9034	c.8595C>A	c.(8593-8595)CCC>CCA	p.P2865P		NM_001999	NP_001990	P35556	FBN2_HUMAN	fibrillin 2 precursor	2865					bone trabecula formation|negative regulation of transforming growth factor beta receptor signaling pathway by extracellular sequestering of TGFbeta|positive regulation of bone mineralization|positive regulation of osteoblast differentiation	microfibril	calcium ion binding|extracellular matrix structural constituent			ovary(8)|large_intestine(4)|pancreas(1)|kidney(1)|skin(1)	15		all_cancers(142;0.0216)|Prostate(80;0.0551)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0821)|Epithelial(69;0.146)		TGTATGTGCCGGGCATGAGCT	0.507			NA											73	42					8.2577e-42	2.18512e-40	0.000147903	1	0
CATSPER3	347732	broad.mit.edu	37	5	134303734	134303734	+	Missense_Mutation	SNP	T	T	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr5:134303734T>C	uc003lag.2	+	1	121	c.53T>C	c.(52-54)GTT>GCT	p.V18A	PCBD2_uc011cxw.1_3'UTR	NM_178019	NP_821138	Q86XQ3	CTSR3_HUMAN	cation channel, sperm associated 3	18	Cytoplasmic (Potential).				cell differentiation|multicellular organismal development|spermatogenesis	cilium|flagellar membrane|integral to membrane	calcium channel activity|voltage-gated ion channel activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0233)			AGTTCACCAGTTGACACTACA	0.383			NA											21	12					0	0	9.22233e-05	0	0
BRD8	10902	broad.mit.edu	37	5	137488277	137488277	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr5:137488277G>C	uc003lcf.1	-	21	2805	c.2750C>G	c.(2749-2751)CCG>CGG	p.P917R	BRD8_uc003lcc.1_Intron	NM_139199	NP_631938	Q9H0E9	BRD8_HUMAN	bromodomain containing 8 isoform 2	917					cell surface receptor linked signaling pathway|histone H2A acetylation|histone H4 acetylation|regulation of growth|regulation of transcription from RNA polymerase II promoter	mitochondrion|NuA4 histone acetyltransferase complex	sequence-specific DNA binding transcription factor activity|thyroid hormone receptor activity			ovary(1)	1			KIRC - Kidney renal clear cell carcinoma(527;0.0101)|Kidney(363;0.0109)			TTCTCTCTCCGGGCTGCTTTC	0.552			NA											6	191					0	0	0.000157383	0	0
PCDHB5	26167	broad.mit.edu	37	5	140516259	140516259	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr5:140516259G>T	uc003liq.2	+	1	1460	c.1243G>T	c.(1243-1245)GAG>TAG	p.E415*		NM_015669	NP_056484	Q9Y5E4	PCDB5_HUMAN	protocadherin beta 5 precursor	415	Cadherin 4.|Extracellular (Potential).				calcium-dependent cell-cell adhesion|homophilic cell adhesion|synapse assembly|synaptic transmission	integral to membrane|plasma membrane	calcium ion binding|protein binding			skin(3)|ovary(2)	5			KIRC - Kidney renal clear cell carcinoma(527;0.00185)|Kidney(363;0.00339)			GAGCCAAGCCGAGTACAACAT	0.502			NA											31	21					6.84511e-11	1.583e-09	8.91981e-05	1	0
PCDHGA10	56106	broad.mit.edu	37	5	140794435	140794435	+	Nonsense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr5:140794435G>T	uc003lkl.1	+	1	1693	c.1693G>T	c.(1693-1695)GAG>TAG	p.E565*	PCDHGA1_uc003lji.1_Intron|PCDHGA2_uc003ljk.1_Intron|PCDHGA3_uc003ljm.1_Intron|PCDHGA3_uc010jfx.1_Intron|PCDHGB1_uc003ljo.1_Intron|PCDHGA4_uc003ljq.1_Intron|PCDHGB2_uc003ljs.1_Intron|PCDHGA5_uc003lju.1_Intron|PCDHGB3_uc003ljw.1_Intron|PCDHGA6_uc003ljy.1_Intron|PCDHGA7_uc003lka.1_Intron|PCDHGB4_uc003lkc.1_Intron|PCDHGA8_uc003lkd.1_Intron|PCDHGB5_uc003lkf.1_Intron|PCDHGA9_uc003lkh.1_Intron|PCDHGB6_uc003lkj.1_Intron|PCDHGA10_uc011day.1_Nonsense_Mutation_p.E565*|PCDHGB7_uc003lkm.2_5'Flank|PCDHGB7_uc003lkn.1_5'Flank	NM_018913	NP_061736	Q9Y5H3	PCDGA_HUMAN	protocadherin gamma subfamily A, 10 isoform 1	565	Extracellular (Potential).|Cadherin 5.				homophilic cell adhesion	integral to membrane|plasma membrane	calcium ion binding				0			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			CAATGCGCCCGAGATCCTGTA	0.652			NA											64	34					7.05995e-25	1.79566e-23	0.000147903	1	0
ARHGEF37	389337	broad.mit.edu	37	5	148997825	148997825	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr5:148997825C>G	uc003lra.1	+	6	809	c.745C>G	c.(745-747)CGG>GGG	p.R249G		NM_001001669	NP_001001669	A1IGU5	ARH37_HUMAN	hypothetical protein LOC389337	249					regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity				0						GAAGACCACCCGGCTGAGCCA	0.652			NA											3	39					0	0	6.4e-05	0	0
WWC1	23286	broad.mit.edu	37	5	167850972	167850972	+	Missense_Mutation	SNP	C	C	G	rs146672179	byFrequency	TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr5:167850972C>G	uc003lzu.2	+	11	1802	c.1709C>G	c.(1708-1710)CCG>CGG	p.P570R	WWC1_uc003lzv.2_Missense_Mutation_p.P570R|WWC1_uc011den.1_Missense_Mutation_p.P570R|WWC1_uc003lzw.2_Missense_Mutation_p.P369R	NM_015238	NP_056053	Q8IX03	KIBRA_HUMAN	WW and C2 domain containing 1 isoform 3	570					cell migration|positive regulation of MAPKKK cascade|regulation of hippo signaling cascade|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|perinuclear region of cytoplasm|ruffle membrane	protein binding|transcription coactivator activity			ovary(2)|skin(2)|breast(1)	5	Renal(175;0.000212)|Lung NSC(126;0.0875)|all_lung(126;0.166)	Medulloblastoma(196;0.0399)|all_neural(177;0.0577)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)	all cancers(165;0.0364)|Epithelial(171;0.0765)|OV - Ovarian serous cystadenocarcinoma(192;0.0918)		TTTGAAGACCCGGAGCTGAGT	0.602			NA											4	117					0	0	1.23904e-05	0	0
DOCK2	1794	broad.mit.edu	37	5	169127118	169127118	+	Silent	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr5:169127118G>T	uc003maf.2	+	13	1313	c.1233G>T	c.(1231-1233)CTG>CTT	p.L411L	DOCK2_uc011der.1_RNA|DOCK2_uc010jjl.1_5'Flank	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	411					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CCAGGAAGCTGGGATTCCCAG	0.537			NA											8	139					0.000274275	0.00558288	0.000274275	1	0
DOCK2	1794	broad.mit.edu	37	5	169188557	169188557	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr5:169188557C>A	uc003maf.2	+	25	2562	c.2482C>A	c.(2482-2484)CCT>ACT	p.P828T	DOCK2_uc011der.1_RNA|DOCK2_uc010jjm.2_Missense_Mutation_p.P320T	NM_004946	NP_004937	Q92608	DOCK2_HUMAN	dedicator of cytokinesis 2	828					actin cytoskeleton organization|regulation of defense response to virus by virus|viral reproduction	cytoskeleton|cytosol|endomembrane system|membrane	electron carrier activity|GTP binding|GTPase binding|heme binding|Rac guanyl-nucleotide exchange factor activity|T cell receptor binding			ovary(5)|pancreas(2)	7	Renal(175;0.000159)|Lung NSC(126;0.0221)|all_lung(126;0.0337)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.53e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000525)			CTGCATCCCTCCTGTGAAACT	0.493			NA											149	55					4.76223e-79	1.27985e-77	0.000147903	1	0
FGF18	8817	broad.mit.edu	37	5	170863159	170863159	+	Silent	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr5:170863159G>C	uc003mbk.2	+	3	669	c.132G>C	c.(130-132)CGG>CGC	p.R44R		NM_003862	NP_003853	O76093	FGF18_HUMAN	fibroblast growth factor 18 precursor	44					cell-cell signaling|fibroblast growth factor receptor signaling pathway|insulin receptor signaling pathway|positive regulation of cell proliferation	extracellular space|nucleolus	growth factor activity|type 1 fibroblast growth factor receptor binding|type 2 fibroblast growth factor receptor binding				0	Renal(175;0.000159)|Lung NSC(126;0.011)|all_lung(126;0.0175)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			CGCGGGCTCGGGACGATGTGA	0.637			NA											3	27					0	0	1.23904e-05	0	0
C5orf25	375484	broad.mit.edu	37	5	175717588	175717588	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr5:175717588G>C	uc003mds.3	+	4	1411	c.1004G>C	c.(1003-1005)GGG>GCG	p.G335A	C5orf25_uc003mdt.3_Intron|C5orf25_uc003mdr.3_Intron|C5orf25_uc011dfk.1_Missense_Mutation_p.G354A|uc003mdu.1_Missense_Mutation_p.G246A			Q8NDZ2	CE025_HUMAN	RecName: Full=Uncharacterized protein C5orf25;	335	Pro-rich.										0	all_cancers(89;0.00381)|Renal(175;0.000269)|Lung NSC(126;0.0122)|all_lung(126;0.0193)	Medulloblastoma(196;0.0208)|all_neural(177;0.0416)|all_hematologic(541;0.214)	Kidney(164;3.85e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	Kidney(146;0.119)		CACTCATCAGGGGACGTGACA	0.522			NA											5	125					0	0	1.23904e-05	0	0
ZNF454	285676	broad.mit.edu	37	5	178392340	178392340	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr5:178392340G>A	uc003mjo.1	+	5	1206	c.935G>A	c.(934-936)AGG>AAG	p.R312K	ZNF454_uc010jkz.1_Missense_Mutation_p.R312K	NM_182594	NP_872400	Q8N9F8	ZN454_HUMAN	zinc finger protein 454	312	C2H2-type 5.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(2)|lung(1)	3	all_cancers(89;0.000904)|Renal(175;0.000159)|all_epithelial(37;0.000167)|Lung NSC(126;0.00199)|all_lung(126;0.00351)	all_cancers(40;0.225)|all_neural(177;0.00802)|Medulloblastoma(196;0.0145)|all_hematologic(541;0.248)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)	all cancers(165;0.234)		TTTGTGTGCAGGGCACACCTT	0.378			NA											49	16					0	0	0.000147903	0	0
BTNL9	153579	broad.mit.edu	37	5	180486691	180486691	+	Silent	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr5:180486691G>C	uc003mmt.2	+	11	1668	c.1437G>C	c.(1435-1437)TCG>TCC	p.S479S		NM_152547	NP_689760	Q6UXG8	BTNL9_HUMAN	butyrophilin-like 9 precursor	479	Cytoplasmic (Potential).|B30.2/SPRY.					integral to membrane				ovary(1)|central_nervous_system(1)	2	all_cancers(89;2.45e-05)|all_epithelial(37;3.77e-06)|Renal(175;0.000159)|Lung NSC(126;0.00211)|all_lung(126;0.00371)|Breast(19;0.114)	all_cancers(40;0.0801)|Medulloblastoma(196;0.0392)|all_neural(177;0.0529)|all_hematologic(541;0.191)	Kidney(164;2.23e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000178)			ACACCTTCTCGGGCGCGCTCT	0.672			NA											3	35					0	0	6.4e-05	0	0
RREB1	6239	broad.mit.edu	37	6	7231086	7231086	+	Silent	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr6:7231086C>A	uc003mxc.2	+	10	3144	c.2754C>A	c.(2752-2754)TCC>TCA	p.S918S	RREB1_uc003mxb.2_Silent_p.S918S|RREB1_uc010jnx.2_Silent_p.S918S	NM_001003698	NP_001003698	Q92766	RREB1_HUMAN	ras responsive element binding protein 1 isoform	918					multicellular organismal development|positive regulation of transcription, DNA-dependent|Ras protein signal transduction|transcription from RNA polymerase II promoter	cytoplasm|nuclear speck	DNA binding|zinc ion binding			ovary(4)|large_intestine(2)|pancreas(2)|skin(2)|breast(1)	11	Ovarian(93;0.0398)	all_hematologic(90;0.0384)|Prostate(151;0.191)				AAAACATCTCCTTTCTGAGCC	0.567			NA											32	29					3.76114e-14	8.87705e-13	0.000132358	1	0
FAM65B	9750	broad.mit.edu	37	6	24843408	24843408	+	Silent	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr6:24843408C>T	uc003neo.1	-	14	1778	c.1602G>A	c.(1600-1602)GAG>GAA	p.E534E	FAM65B_uc011djs.1_Silent_p.E513E|FAM65B_uc011dju.1_Silent_p.E518E|FAM65B_uc003nep.2_Silent_p.E484E|FAM65B_uc011djt.1_Silent_p.E484E	NM_014722	NP_055537	Q9Y4F9	FA65B_HUMAN	hypothetical protein LOC9750 isoform 1	534					cell differentiation|muscle organ development	cytoskeleton|filopodium|mitochondrion	binding			ovary(1)	1						CAACATCATTCTCAAGGAACA	0.572			NA											56	78					0	0	0.000147903	0	0
HIST1H2BM	8342	broad.mit.edu	37	6	27783099	27783099	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr6:27783099G>C	uc003njo.2	+	1	278	c.278G>C	c.(277-279)AGG>ACG	p.R93T	HIST1H2AJ_uc003njn.1_5'Flank	NM_003521	NP_003512	Q99879	H2B1M_HUMAN	histone cluster 1, H2bm	93					nucleosome assembly	nucleosome|nucleus	DNA binding			large_intestine(1)	1						ATCACTTCGAGGGAGATCCAG	0.587			NA											4	82					0	0	1.23904e-05	0	0
TRIM27	5987	broad.mit.edu	37	6	28879488	28879489	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr6:28879488_28879489CC>AA	uc003nlr.2	-	4	1113_1114	c.754_755GG>TT	c.(754-756)GGG>TTG	p.G252L	TRIM27_uc003nls.2_Missense_Mutation_p.G252L|TRIM27_uc003nlt.1_Missense_Mutation_p.G252L	NM_006510	NP_006501	P14373	TRI27_HUMAN	ret finger protein	252					cell proliferation|negative regulation of gene expression, epigenetic|negative regulation of transcription from RNA polymerase II promoter|protein trimerization|spermatogenesis|transcription, DNA-dependent	cytoplasm|integral to plasma membrane|membrane fraction|nuclear membrane|PML body	DNA binding|protein binding|transmembrane receptor protein tyrosine kinase activity|zinc ion binding			ovary(1)	1						CAATGTGTCCCCAATGTCCTGC	0.376			NA	T	RET	papillary thyroid								8	102					0	0	6.4e-05	0	0
OR2J2	26707	broad.mit.edu	37	6	29141763	29141763	+	Silent	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr6:29141763G>C	uc011dlm.1	+	1	453	c.351G>C	c.(349-351)GTG>GTC	p.V117V		NM_030905	NP_112167	O76002	OR2J2_HUMAN	olfactory receptor, family 2, subfamily J,	117	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0						TCCTACTGGTGGTGATGTCAT	0.488			NA											6	320					0	0	3.59834e-05	0	0
OR11A1	26531	broad.mit.edu	37	6	29395095	29395095	+	Silent	SNP	T	T	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr6:29395095T>A	uc003nmg.2	-	1	415	c.324A>T	c.(322-324)CTA>CTT	p.L108L		NM_013937	NP_039225	Q9GZK7	O11A1_HUMAN	olfactory receptor, family 11, subfamily A,	108	Helical; Name=3; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)	1						CAGCTGTGGCTAGAGAGCCGA	0.537			NA											25	26					0	0	0.00047179	0	0
COL11A2	1302	broad.mit.edu	37	6	33133723	33133723	+	Silent	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr6:33133723G>T	uc003ocx.1	-	62	4695	c.4467C>A	c.(4465-4467)GGC>GGA	p.G1489G	COL11A2_uc010jul.1_Intron|COL11A2_uc003ocy.1_Silent_p.G1403G|COL11A2_uc003ocz.1_Silent_p.G1382G	NM_080680	NP_542411	P13942	COBA2_HUMAN	collagen, type XI, alpha 2 isoform 1	1489	Triple-helical region.				cartilage development|cell adhesion|collagen fibril organization|sensory perception of sound|soft palate development	collagen type XI	extracellular matrix structural constituent conferring tensile strength|protein binding, bridging			ovary(3)|skin(2)	5						GTCCTGGAGGGCCCTGCACAC	0.607	Melanoma(1;90 116 3946 5341 17093)		NA											10	20					7.48243e-07	1.66062e-05	0.000442599	1	0
RGL2	5863	broad.mit.edu	37	6	33260873	33260873	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr6:33260873C>A	uc003odv.2	-	16	2060	c.1927G>T	c.(1927-1929)GGG>TGG	p.G643W	RGL2_uc003odu.2_Missense_Mutation_p.G203W|RGL2_uc010jur.2_Missense_Mutation_p.G203W|RGL2_uc003odw.2_Missense_Mutation_p.G561W	NM_004761	NP_004752	O15211	RGL2_HUMAN	ral guanine nucleotide dissociation	643					Ras protein signal transduction|regulation of small GTPase mediated signal transduction	intracellular	Ras guanyl-nucleotide exchange factor activity			skin(3)|lung(1)|breast(1)|pancreas(1)	6						GCCCCTGGCCCAGATCCCTCT	0.622			NA											10	233					3.86212e-05	0.000822643	3.86212e-05	1	0
PNPLA1	285848	broad.mit.edu	37	6	36259267	36259267	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr6:36259267C>G	uc010jwf.2	+	2	376	c.376C>G	c.(376-378)CGC>GGC	p.R126G	PNPLA1_uc003olw.1_Missense_Mutation_p.R31G|PNPLA1_uc010jwe.1_Missense_Mutation_p.R31G	NM_001145717	NP_001139189	Q8N8W4	PLPL1_HUMAN	patatin-like phospholipase domain containing 1	126	Patatin.				lipid catabolic process		hydrolase activity			large_intestine(1)|pancreas(1)|breast(1)|skin(1)	4						GAGCCTCACCCGCTTAACGGA	0.602			NA											3	16					0	0	6.4e-05	0	0
KCNK16	83795	broad.mit.edu	37	6	39285675	39285675	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr6:39285675A>G	uc003ooq.2	-	3	396	c.382T>C	c.(382-384)TAT>CAT	p.Y128H	KCNK16_uc003oor.3_Missense_Mutation_p.Y128H|KCNK16_uc010jwy.2_Missense_Mutation_p.Y128H|KCNK16_uc011dtz.1_Missense_Mutation_p.Y128H	NM_032115	NP_115491	Q96T55	KCNKG_HUMAN	potassium channel, subfamily K, member 16	128	Helical; (Potential).					integral to membrane	potassium channel activity|voltage-gated ion channel activity			ovary(2)|skin(1)	3						AACAGGGCATAGAAGACACAG	0.587			NA											15	25					0	0	0.000422831	0	0
MEP1A	4224	broad.mit.edu	37	6	46801138	46801138	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr6:46801138G>C	uc010jzh.1	+	11	1514	c.1472G>C	c.(1471-1473)GGG>GCG	p.G491A	MEP1A_uc011dwg.1_Missense_Mutation_p.G213A|MEP1A_uc011dwh.1_Missense_Mutation_p.G519A|MEP1A_uc011dwi.1_Missense_Mutation_p.G391A	NM_005588	NP_005579	Q16819	MEP1A_HUMAN	meprin A alpha precursor	491	MATH.|Extracellular (Potential).				digestion|proteolysis	extracellular space|integral to plasma membrane|soluble fraction	metalloendopeptidase activity|zinc ion binding			pancreas(2)|ovary(1)	3			Lung(136;0.192)			GTGTGCAGTGGGGAGAACGAT	0.473			NA											4	145					0	0	0.00024832	0	0
PGK2	5232	broad.mit.edu	37	6	49753693	49753693	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr6:49753693A>G	uc003ozu.2	-	1	1315	c.1208T>C	c.(1207-1209)CTG>CCG	p.L403P		NM_138733	NP_620061	P07205	PGK2_HUMAN	phosphoglycerate kinase 2	403					glycolysis	cytosol	ATP binding|phosphoglycerate kinase activity			ovary(1)	1	Lung NSC(77;0.0402)					TTTACCTTCCAGAAGCTCTAG	0.473			NA											61	72					0	0	0.000147903	0	0
GSTA5	221357	broad.mit.edu	37	6	52705574	52705574	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr6:52705574C>G	uc003pba.1	-	2	108	c.38G>C	c.(37-39)CGG>CCG	p.R13P		NM_153699	NP_714543	Q7RTV2	GSTA5_HUMAN	glutathione S-transferase alpha 5	13	GST N-terminal.				glutathione metabolic process|xenobiotic metabolic process	cytosol	glutathione transferase activity			ovary(1)	1	Lung NSC(77;0.0912)				Glutathione(DB00143)	CATACTGCCCCGTGCATTGGA	0.463			NA											4	102					0	0	1.23904e-05	0	0
DST	667	broad.mit.edu	37	6	56373423	56373423	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr6:56373423C>G	uc003pdf.2	-	69	12814	c.12786G>C	c.(12784-12786)TTG>TTC	p.L4262F	DST_uc003pcz.3_Missense_Mutation_p.L4084F|DST_uc011dxj.1_Missense_Mutation_p.L4113F|DST_uc011dxk.1_Missense_Mutation_p.L4124F|DST_uc003pcy.3_Missense_Mutation_p.L3758F	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	6170					cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TGGTAACTATCAATGACATGT	0.428			NA											70	123					0	0	0.000147903	0	0
DST	667	broad.mit.edu	37	6	56516036	56516036	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr6:56516036G>T	uc003pdf.2	-	10	1150	c.1122C>A	c.(1120-1122)GAC>GAA	p.D374E	DST_uc003pcz.3_Missense_Mutation_p.D196E|DST_uc011dxj.1_Missense_Mutation_p.D225E|DST_uc011dxk.1_Missense_Mutation_p.D236E|DST_uc011dxl.1_Missense_Mutation_p.D225E|DST_uc003pde.2_Missense_Mutation_p.D312E	NM_001144769	NP_001138241	Q03001	DYST_HUMAN	dystonin isoform 2	196	CH 2.|Actin-binding.				cell adhesion|cell cycle arrest|cell motility|hemidesmosome assembly|integrin-mediated signaling pathway|intermediate filament cytoskeleton organization|maintenance of cell polarity|microtubule cytoskeleton organization|response to wounding	actin cytoskeleton|axon|axon part|basement membrane|cell cortex|cell leading edge|cytoplasmic membrane-bounded vesicle|endoplasmic reticulum membrane|hemidesmosome|hemidesmosome|integral to membrane|intermediate filament|intermediate filament cytoskeleton|microtubule cytoskeleton|microtubule plus end|nuclear envelope|sarcomere|Z disc	actin binding|calcium ion binding|integrin binding|microtubule plus-end binding|protein binding|protein C-terminus binding|protein homodimerization activity			ovary(7)|central_nervous_system(6)|upper_aerodigestive_tract(1)	14	Lung NSC(77;0.103)		LUSC - Lung squamous cell carcinoma(124;0.0485)|Lung(124;0.0956)			TATCTATCAGGTCCGGCCTAG	0.343			NA											9	14					0.000274275	0.00558288	0.000274275	1	0
DOPEY1	23033	broad.mit.edu	37	6	83838812	83838812	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr6:83838812C>G	uc003pjs.1	+	16	2186	c.1926C>G	c.(1924-1926)TCC>TCG	p.S642S	DOPEY1_uc011dyy.1_Silent_p.S633S|DOPEY1_uc010kbl.1_Silent_p.S633S	NM_015018	NP_055833	Q5JWR5	DOP1_HUMAN	dopey family member 1	642					protein transport					ovary(2)|breast(1)|central_nervous_system(1)	4		all_cancers(76;2.29e-06)|Acute lymphoblastic leukemia(125;3.41e-06)|all_hematologic(105;0.000865)|all_epithelial(107;0.00203)		BRCA - Breast invasive adenocarcinoma(397;0.053)		AAACAGCATCCACTGTGGGAT	0.522			NA											4	102					0	0	0.00024832	0	0
CNR1	1268	broad.mit.edu	37	6	88854765	88854765	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr6:88854765T>A	uc011dzq.1	-	2	3792	c.229A>T	c.(229-231)AAC>TAC	p.N77Y	CNR1_uc010kbz.2_Missense_Mutation_p.N77Y|CNR1_uc011dzr.1_Missense_Mutation_p.N77Y|CNR1_uc011dzs.1_Missense_Mutation_p.N77Y|CNR1_uc003pmq.3_Missense_Mutation_p.N77Y|CNR1_uc011dzt.1_Missense_Mutation_p.N77Y|CNR1_uc010kca.2_Missense_Mutation_p.N44Y	NM_001160260	NP_001153732	P21554	CNR1_HUMAN	cannabinoid receptor 1 isoform a	77	Extracellular (Potential).				G-protein signaling, coupled to cAMP nucleotide second messenger	integral to plasma membrane	cannabinoid receptor activity|protein binding			skin(2)	2		all_cancers(76;8.24e-09)|Acute lymphoblastic leukemia(125;2.15e-10)|Prostate(29;4.11e-10)|all_hematologic(105;1.08e-06)|all_epithelial(107;0.00011)		BRCA - Breast invasive adenocarcinoma(108;0.15)	Marinol(DB00470)|Nabilone(DB00486)|Rimonabant(DB06155)	TCTGTAATGTTCACCTGGTCT	0.473			NA											15	24					0	0	0.000219431	0	0
COQ3	51805	broad.mit.edu	37	6	99823932	99823932	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr6:99823932G>C	uc003ppk.2	-	5	640	c.613C>G	c.(613-615)CTG>GTG	p.L205V		NM_017421	NP_059117	Q9NZJ6	COQ3_HUMAN	hexaprenyldihydroxybenzoate methyltransferase	205					glycerol metabolic process|ubiquinone biosynthetic process	mitochondrial matrix	2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity|3-demethylubiquinone-9 3-O-methyltransferase activity|hexaprenyldihydroxybenzoate methyltransferase activity			upper_aerodigestive_tract(1)	1		all_cancers(76;1.24e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00716)|Colorectal(196;0.0691)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0625)		ATCTCTTCCAGGGAACACACT	0.393			NA											5	172					0	0	3.59834e-05	0	0
PHACTR2	9749	broad.mit.edu	37	6	144033228	144033228	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr6:144033228G>A	uc003qjq.3	+	2	219	c.89G>A	c.(88-90)AGA>AAA	p.R30K	PHACTR2_uc010khh.2_Missense_Mutation_p.R30K|PHACTR2_uc010khi.2_Missense_Mutation_p.R41K|PHACTR2_uc003qjr.3_Missense_Mutation_p.R41K	NM_014721	NP_055536	O75167	PHAR2_HUMAN	phosphatase and actin regulator 2 isoform 3	30							actin binding|protein phosphatase inhibitor activity			ovary(2)	2				OV - Ovarian serous cystadenocarcinoma(155;1.58e-05)|GBM - Glioblastoma multiforme(68;0.0386)		CCCTTCAAAAGAAAGGGGAAA	0.428	Pancreas(12;292 433 7358 48260 52635)|Ovarian(20;501 618 3485 36581 49208)		NA											60	96					0	0	0.000147903	0	0
STXBP5	134957	broad.mit.edu	37	6	147684611	147684611	+	Missense_Mutation	SNP	C	C	T	rs143796366		TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr6:147684611C>T	uc003qlz.2	+	24	2847	c.2686C>T	c.(2686-2688)CGG>TGG	p.R896W	STXBP5_uc010khz.1_Missense_Mutation_p.R860W|STXBP5_uc003qlx.2_RNA|STXBP5_uc003qly.2_Missense_Mutation_p.R551W	NM_001127715	NP_001121187	Q5T5C0	STXB5_HUMAN	syntaxin binding protein 5 (tomosyn) isoform b	896	WD 12.				exocytosis|positive regulation of exocytosis|protein transport	cell junction|cytoplasmic vesicle membrane|nicotinic acetylcholine-gated receptor-channel complex|synaptic vesicle	syntaxin-1 binding				0		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;1.77e-09)|GBM - Glioblastoma multiforme(68;0.0694)		ATTGAAAAAACGGCGGCCTGT	0.438			NA											11	25					0	0	0.00010058	0	0
NUP43	348995	broad.mit.edu	37	6	150067629	150067629	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr6:150067629C>G	uc003qmz.2	-	1	60	c.3G>C	c.(1-3)ATG>ATC	p.M1I	NUP43_uc011eee.1_RNA|NUP43_uc011eef.1_Missense_Mutation_p.M1I	NM_198887	NP_942590	Q8NFH3	NUP43_HUMAN	nucleoporin 43kDa	1					carbohydrate metabolic process|cell division|chromosome segregation|glucose transport|mitotic prometaphase|mRNA transport|protein transport|regulation of glucose transport|transmembrane transport|viral reproduction	condensed chromosome kinetochore|cytosol|Nup107-160 complex	protein binding			upper_aerodigestive_tract(1)	1		Ovarian(120;0.0164)		OV - Ovarian serous cystadenocarcinoma(155;4.71e-13)|GBM - Glioblastoma multiforme(68;0.101)		AAATTTCCTCCATGCCGAAAG	0.567			NA									OREG0017720	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	5	152					0	0	1.23904e-05	0	0
PLEKHG1	57480	broad.mit.edu	37	6	151161418	151161418	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr6:151161418C>G	uc003qny.1	+	17	3856	c.3544C>G	c.(3544-3546)CAG>GAG	p.Q1182E	PLEKHG1_uc011eem.1_Missense_Mutation_p.Q1241E	NM_001029884	NP_001025055	Q9ULL1	PKHG1_HUMAN	pleckstrin homology domain containing, family G	1182					regulation of Rho protein signal transduction	intracellular	Rho guanyl-nucleotide exchange factor activity			ovary(2)	2			BRCA - Breast invasive adenocarcinoma(37;0.0923)	OV - Ovarian serous cystadenocarcinoma(155;6.69e-13)		TCACAGGTCCCAGTCATCTTC	0.468			NA											6	204					0	0	3.59834e-05	0	0
AKAP12	9590	broad.mit.edu	37	6	151671920	151671920	+	Silent	SNP	C	C	G	rs140093591	byFrequency	TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr6:151671920C>G	uc011eep.1	+	4	2634	c.2394C>G	c.(2392-2394)CCC>CCG	p.P798P	AKAP12_uc003qoe.2_Silent_p.P798P|AKAP12_uc003qof.2_Silent_p.P700P|AKAP12_uc010kim.2_Intron|AKAP12_uc003qog.2_Silent_p.P693P	NM_005100	NP_005091	Q02952	AKA12_HUMAN	A kinase (PRKA) anchor protein 12 isoform 1	798	AKAP 3.				G-protein coupled receptor protein signaling pathway|positive regulation of cAMP biosynthetic process|positive regulation of protein kinase A signaling cascade|protein targeting	cell cortex|cytoskeleton|plasma membrane	adenylate cyclase binding|protein kinase A binding			large_intestine(2)|ovary(2)|upper_aerodigestive_tract(1)|lung(1)|skin(1)|pancreas(1)	8		Ovarian(120;0.125)	BRCA - Breast invasive adenocarcinoma(37;0.175)	OV - Ovarian serous cystadenocarcinoma(155;2.98e-11)		ACACTGAACCCGGTAAAGAAG	0.463	Melanoma(141;1616 1805 10049 24534 51979)		NA											4	89					0	0	0.00024832	0	0
MAP3K4	4216	broad.mit.edu	37	6	161532908	161532908	+	Silent	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr6:161532908G>C	uc003qtn.2	+	24	4579	c.4437G>C	c.(4435-4437)CTG>CTC	p.L1479L	MAP3K4_uc003qto.2_Silent_p.L1429L|MAP3K4_uc011efz.1_RNA|MAP3K4_uc011ega.1_Silent_p.L932L|MAP3K4_uc003qtp.2_Silent_p.L415L|MAP3K4_uc003qtq.2_Silent_p.L168L	NM_005922	NP_005913	Q9Y6R4	M3K4_HUMAN	mitogen-activated protein kinase kinase kinase 4	1479	Protein kinase.				activation of MAPKK activity|JNK cascade|positive regulation of JUN kinase activity	perinuclear region of cytoplasm	ATP binding|MAP kinase kinase kinase activity|metal ion binding|protein binding			ovary(3)|lung(3)|skin(2)|stomach(1)	9		Breast(66;0.000776)|Ovarian(120;0.0367)|Prostate(117;0.0771)		OV - Ovarian serous cystadenocarcinoma(65;1.85e-18)|BRCA - Breast invasive adenocarcinoma(81;3.04e-05)		TAATCAAACTGGGAGATTTTG	0.458			NA											7	173					0	0	0.000157383	0	0
THBS2	7058	broad.mit.edu	37	6	169637803	169637803	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr6:169637803C>A	uc003qwt.2	-	9	1465	c.1217G>T	c.(1216-1218)CGG>CTG	p.R406L		NM_003247	NP_003238	P35442	TSP2_HUMAN	thrombospondin 2 precursor	406	TSP type-1 1.				cell adhesion	extracellular region	calcium ion binding|heparin binding|protein binding|structural molecule activity			ovary(5)	5		Breast(66;1.78e-05)|Ovarian(120;0.0728)|Esophageal squamous(34;0.247)		OV - Ovarian serous cystadenocarcinoma(33;1.85e-21)|BRCA - Breast invasive adenocarcinoma(81;1.43e-06)|GBM - Glioblastoma multiforme(31;0.000379)		GTCACAGGACCGGCCTCTCTG	0.652	Esophageal Squamous(91;219 1934 18562 44706)		NA											16	24					3.41278e-10	7.78771e-09	5.01169e-05	1	0
AMZ1	155185	broad.mit.edu	37	7	2749348	2749348	+	Silent	SNP	G	G	A	rs150265717		TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:2749348G>A	uc003smr.1	+	6	1207	c.846G>A	c.(844-846)GCG>GCA	p.A282A	AMZ1_uc003sms.1_Missense_Mutation_p.A226T|AMZ1_uc011jwa.1_Silent_p.A31A	NM_133463	NP_597720	Q400G9	AMZ1_HUMAN	archaelysin family metallopeptidase 1	282							metallopeptidase activity|zinc ion binding				0		Ovarian(82;0.0779)		OV - Ovarian serous cystadenocarcinoma(56;5.03e-14)		TGCAGGGTGCGCTCAGCCTGG	0.667			NA									OREG0017838	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	8	17					0	0	0.000157383	0	0
RNF216	54476	broad.mit.edu	37	7	5662579	5662579	+	Missense_Mutation	SNP	C	C	G	rs150725128		TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:5662579C>G	uc003soy.1	-	17	2703	c.2513G>C	c.(2512-2514)CGG>CCG	p.R838P	RNF216_uc010ksz.1_Missense_Mutation_p.R460P|RNF216_uc010kta.1_Missense_Mutation_p.R460P|RNF216_uc011jwj.1_Missense_Mutation_p.R460P|RNF216_uc003sox.1_Missense_Mutation_p.R895P	NM_207116	NP_996999	Q9NWF9	RN216_HUMAN	ring finger protein 216 isoform b	838	Pro-rich.				apoptosis|interspecies interaction between organisms|proteasomal ubiquitin-dependent protein catabolic process|protein K48-linked ubiquitination|regulation of defense response to virus by host|regulation of interferon-beta production	cytoplasm|nucleus|nucleus	ligase activity|protein binding|protein binding|zinc ion binding			ovary(3)|breast(2)	5		Ovarian(82;0.07)		UCEC - Uterine corpus endometrioid carcinoma (126;0.135)|OV - Ovarian serous cystadenocarcinoma(56;2.69e-13)		ATAGTTGACCCGCACGTTGGG	0.642			NA											5	108					0	0	1.23904e-05	0	0
ARL4A	10124	broad.mit.edu	37	7	12727889	12727889	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:12727889G>C	uc003ssp.2	+	2	287	c.10G>C	c.(10-12)GGG>CGG	p.G4R	ARL4A_uc003ssq.2_Missense_Mutation_p.G4R|ARL4A_uc003ssr.2_Missense_Mutation_p.G4R|ARL4A_uc003sss.2_Missense_Mutation_p.G4R	NM_001037164	NP_001032241	P40617	ARL4A_HUMAN	ADP-ribosylation factor-like 4A	4					small GTPase mediated signal transduction	cytoplasm|nucleolus|plasma membrane	GTP binding|protein binding				0				UCEC - Uterine corpus endometrioid carcinoma (126;0.176)		AATGGGGAATGGGCTGTCAGA	0.428			NA											5	149					0	0	3.59834e-05	0	0
SNX13	23161	broad.mit.edu	37	7	17843055	17843055	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:17843055T>A	uc003stw.1	-	21	2459	c.2246A>T	c.(2245-2247)CAA>CTA	p.Q749L	SNX13_uc003stv.2_Missense_Mutation_p.Q738L|SNX13_uc010kuc.2_Missense_Mutation_p.Q535L|SNX13_uc010kub.2_Missense_Mutation_p.Q144L			Q9Y5W8	SNX13_HUMAN	SubName: Full=Putative uncharacterized protein SNX13; SubName: Full=Sorting nexin 13, isoform CRA_g;	749					cell communication|intracellular protein transport|negative regulation of signal transduction|positive regulation of GTPase activity	early endosome membrane	phosphatidylinositol binding|signal transducer activity			central_nervous_system(2)|kidney(1)	3	Lung NSC(10;0.0261)|all_lung(11;0.0521)					AAAAAATGATTGCTTTATGTC	0.338			NA											12	22					0	0	0.000219431	0	0
SP8	221833	broad.mit.edu	37	7	20824767	20824767	+	Silent	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:20824767G>A	uc003suy.2	-	3	856	c.615C>T	c.(613-615)GCC>GCT	p.A205A	SP8_uc003suz.2_Silent_p.A223A	NM_198956	NP_945194	Q8IXZ3	SP8_HUMAN	Sp8 transcription factor isoform 2	205					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			pancreas(1)	1						TGGAGGCGCCGGCCGAGCCCA	0.746			NA											9	3					0	0	3.86212e-05	0	0
HOXA3	3200	broad.mit.edu	37	7	27147548	27147548	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:27147548G>A	uc011jzl.1	-	3	1518	c.1318C>T	c.(1318-1320)CTC>TTC	p.L440F	HOXA3_uc011jzk.1_Missense_Mutation_p.L282F|HOXA3_uc003syk.2_Missense_Mutation_p.L440F	NM_030661	NP_109377	O43365	HXA3_HUMAN	homeobox A3 isoform a	440					angiogenesis	nucleus	sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			breast(2)	2						AGGTGGGTGAGCTTGGGTGCT	0.547	Esophageal Squamous(136;1368 1743 5685 7935 50360)		NA											29	50					0	0	8.91981e-05	0	0
TAX1BP1	8887	broad.mit.edu	37	7	27827104	27827104	+	Nonsense_Mutation	SNP	T	T	A	rs141015886		TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:27827104T>A	uc003szl.2	+	8	1078	c.920T>A	c.(919-921)TTA>TAA	p.L307*	TAX1BP1_uc011jzo.1_Nonsense_Mutation_p.L307*|TAX1BP1_uc003szk.2_Nonsense_Mutation_p.L307*|TAX1BP1_uc011jzp.1_Nonsense_Mutation_p.L150*	NM_006024	NP_006015	Q86VP1	TAXB1_HUMAN	Tax1 (human T-cell leukemia virus type I)	307	Potential.				anti-apoptosis|apoptosis|negative regulation of NF-kappaB transcription factor activity|negative regulation of type I interferon production	cytosol	identical protein binding|kinase binding|zinc ion binding			breast(1)	1			GBM - Glioblastoma multiforme(3;0.0823)			TTAAAAAATTTAGATGGGAAC	0.348			NA											57	70					0	0	0.000147903	0	0
NEUROD6	63974	broad.mit.edu	37	7	31378296	31378296	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:31378296G>T	uc003tch.2	-	2	940	c.587C>A	c.(586-588)GCT>GAT	p.A196D		NM_022728	NP_073565	Q96NK8	NDF6_HUMAN	neurogenic differentiation 6	196					cell differentiation|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding			ovary(2)	2						GTGGTGTGCAGCCTCCCCACC	0.552			NA											38	49					2.05212e-20	5.10618e-19	0.000191422	1	0
FIGNL1	63979	broad.mit.edu	37	7	50513930	50513930	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:50513930C>A	uc003tpc.2	-	4	1433	c.1056G>T	c.(1054-1056)CAG>CAT	p.Q352H	FIGNL1_uc003tpb.2_Missense_Mutation_p.Q241H|FIGNL1_uc003tpd.2_Missense_Mutation_p.Q352H|FIGNL1_uc003tpe.2_Missense_Mutation_p.Q352H|FIGNL1_uc010kyy.2_Missense_Mutation_p.Q352H	NM_001042762	NP_001036227	Q6PIW4	FIGL1_HUMAN	fidgetin-like 1	352					ATP metabolic process|negative regulation of apoptosis|osteoblast differentiation|osteoblast proliferation|regulation of cell cycle	cytoplasm|nucleus	ATP binding|magnesium ion binding|nucleoside-triphosphatase activity			ovary(3)	3	Glioma(55;0.08)|all_neural(89;0.245)	Acute lymphoblastic leukemia(4;3.73e-08)|all_hematologic(4;7.51e-06)				TTCCTCCATTCTGCTCTCCCC	0.468			NA											44	74					5.20006e-24	1.31773e-22	0.000106405	1	0
GUSB	2990	broad.mit.edu	37	7	65426034	65426034	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:65426034C>G	uc003tun.2	-	12	1882	c.1806G>C	c.(1804-1806)CTG>CTC	p.L602L	GUSB_uc011kdt.1_Silent_p.L456L	NM_000181	NP_000172	P08236	BGLR_HUMAN	glucuronidase, beta precursor	602					glycosaminoglycan catabolic process	lysosome	beta-glucuronidase activity|cation binding				0						TTTTATTCCCCAGCACTCTCG	0.448			NA											6	228					0	0	3.59834e-05	0	0
POM121C	100101267	broad.mit.edu	37	7	75053400	75053400	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:75053400G>T	uc003udk.3	-	12	1865	c.980C>A	c.(979-981)CCA>CAA	p.P327Q		NM_001099415	NP_001092885	A8CG34	P121C_HUMAN	POM121 membrane glycoprotein (rat)-like	569	Pore side (Potential).				mRNA transport|protein transport|transmembrane transport	endoplasmic reticulum membrane|nuclear membrane|nuclear pore	protein binding				0						GTTGGTGCTTGGGGCCAGGAG	0.607			NA											9	168					1.58986e-06	3.50024e-05	3.86212e-05	1	0
SEMA3C	10512	broad.mit.edu	37	7	80387660	80387660	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:80387660G>T	uc003uhj.2	-	15	2192	c.1630C>A	c.(1630-1632)CCA>ACA	p.P544T	SEMA3C_uc011kgw.1_Missense_Mutation_p.P562T	NM_006379	NP_006370	Q99985	SEM3C_HUMAN	semaphorin 3C precursor	544					immune response|response to drug	membrane	receptor activity			ovary(1)	1						TTCCCAGTTGGGTAGAATCTG	0.502			NA											36	55					9.62906e-15	2.28048e-13	0.000228196	1	0
HGF	3082	broad.mit.edu	37	7	81372699	81372699	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:81372699G>C	uc003uhl.2	-	7	1000	c.835C>G	c.(835-837)CGC>GGC	p.R279G	HGF_uc003uhm.2_Missense_Mutation_p.R274G|HGF_uc003uhn.1_Missense_Mutation_p.R279G|HGF_uc003uho.1_Missense_Mutation_p.R274G	NM_000601	NP_000592	P14210	HGF_HUMAN	hepatocyte growth factor isoform 1	279	Kringle 2.				epithelial to mesenchymal transition|mitosis|platelet activation|platelet degranulation|proteolysis|regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling	platelet alpha granule lumen	growth factor activity|serine-type endopeptidase activity			ovary(2)|central_nervous_system(2)	4						TACTCCCAGCGGGTGTGAGGG	0.473			NA											34	41					0	0	0.000109025	0	0
PCLO	27445	broad.mit.edu	37	7	82544898	82544899	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:82544898_82544899CC>AA	uc003uhx.2	-	7	12692_12693	c.12403_12404GG>TT	c.(12403-12405)GGG>TTG	p.G4135L	PCLO_uc003uhv.2_Missense_Mutation_p.G4135L|PCLO_uc010lec.2_Missense_Mutation_p.G1100L	NM_033026	NP_149015	Q9Y6V0	PCLO_HUMAN	piccolo isoform 1	4066					cytoskeleton organization|synaptic vesicle exocytosis	cell junction|cytoskeleton|synaptic vesicle	calcium ion binding|calcium-dependent phospholipid binding|profilin binding|transporter activity			ovary(7)	7						GCTCTCTGTCCCTCTACGAAAT	0.406			NA											8	149					0	0	6.4e-05	0	0
CROT	54677	broad.mit.edu	37	7	87022321	87022321	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:87022321G>C	uc003uit.2	+	17	1901	c.1656G>C	c.(1654-1656)CAG>CAC	p.Q552H	CROT_uc003uiu.2_Missense_Mutation_p.Q580H	NM_021151	NP_066974	Q9UKG9	OCTC_HUMAN	peroxisomal carnitine O-octanoyltransferase	552					fatty acid beta-oxidation using acyl-CoA oxidase|generation of precursor metabolites and energy|transport	peroxisomal matrix	carnitine O-octanoyltransferase activity			ovary(2)|lung(1)	3	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)				L-Carnitine(DB00583)	TACGAGTCCAGGGAGTGGTAG	0.418			NA											5	197					0	0	1.23904e-05	0	0
ABCB4	5244	broad.mit.edu	37	7	87082321	87082321	+	Nonsense_Mutation	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:87082321G>A	uc003uiv.1	-	6	551	c.475C>T	c.(475-477)CGA>TGA	p.R159*	ABCB4_uc003uiw.1_Nonsense_Mutation_p.R159*|ABCB4_uc003uix.1_Nonsense_Mutation_p.R159*|ABCB4_uc003uiy.2_Nonsense_Mutation_p.R159*	NM_018849	NP_061337	P21439	MDR3_HUMAN	ATP-binding cassette, subfamily B, member 4	159	ABC transmembrane type-1 1.|Cytoplasmic (By similarity).				cellular lipid metabolic process	apical plasma membrane|Golgi membrane|integral to plasma membrane|intercellular canaliculus|membrane fraction	ATP binding|xenobiotic-transporting ATPase activity			ovary(4)|skin(1)|pancreas(1)	6	Esophageal squamous(14;0.0058)|all_lung(186;0.201)|Lung NSC(181;0.203)					ATTTCCTGTCGTAGAATAGCA	0.393			NA											40	70					0	0	0.000319135	0	0
C7orf63	79846	broad.mit.edu	37	7	89929315	89929315	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:89929315G>T	uc010lep.2	+	17	2243	c.1992G>T	c.(1990-1992)TTG>TTT	p.L664F	C7orf63_uc003ukf.2_RNA|C7orf63_uc003ukg.2_Missense_Mutation_p.L339F|C7orf63_uc011khj.1_Missense_Mutation_p.L646F|C7orf63_uc011khk.1_Missense_Mutation_p.L226F	NM_001039706	NP_001034795	A5D8W1	CG063_HUMAN	hypothetical protein LOC79846 isoform 1	664							binding			ovary(1)	1						TAATTAAATTGTGGAGAAAGG	0.338			NA											31	33					2.85442e-18	6.98875e-17	0.000339439	1	0
ANKIB1	54467	broad.mit.edu	37	7	92021572	92021572	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:92021572G>C	uc003ulw.2	+	17	2625	c.2249G>C	c.(2248-2250)TGG>TCG	p.W750S	ANKIB1_uc010lew.1_Intron	NM_019004	NP_061877	Q9P2G1	AKIB1_HUMAN	ankyrin repeat and IBR domain containing 1	750							protein binding|zinc ion binding			lung(1)	1	all_cancers(62;2.06e-09)|all_epithelial(64;9.24e-09)|Breast(17;0.0034)|all_lung(186;0.0509)|Lung NSC(181;0.0692)		STAD - Stomach adenocarcinoma(171;6.16e-05)|all cancers(6;0.00183)|Lung(22;0.123)|LUSC - Lung squamous cell carcinoma(200;0.225)			GGTGGAACATGGGATTGGGAA	0.338			NA											7	470					0	0	0.000274275	0	0
EPHB4	2050	broad.mit.edu	37	7	100411606	100411606	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:100411606C>G	uc003uwn.1	-	9	2117	c.1626G>C	c.(1624-1626)GCG>GCC	p.A542A	EPHB4_uc003uwm.1_Silent_p.A449A|EPHB4_uc010lhj.1_Silent_p.A542A|EPHB4_uc011kkf.1_3'UTR	NM_004444	NP_004435	P54760	EPHB4_HUMAN	EPH receptor B4 precursor	542	Helical; (Potential).				cell proliferation|organ morphogenesis|regulation of angiogenesis	cell surface|integral to plasma membrane	ATP binding|ephrin receptor activity			lung(4)|stomach(3)|skin(3)|central_nervous_system(2)|ovary(2)|breast(1)	15	Lung NSC(181;0.041)|all_lung(186;0.0581)					CTGCCGTGCCCGCAATCAGGG	0.647	GBM(200;2113 3072 25865 52728)		NA											4	75					0	0	3.59834e-05	0	0
DNAJC2	27000	broad.mit.edu	37	7	102963026	102963026	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:102963026C>T	uc003vbo.2	-	9	1116	c.865G>A	c.(865-867)GCC>ACC	p.A289T	PMPCB_uc011kll.1_Intron|DNAJC2_uc003vbn.2_5'UTR|DNAJC2_uc010lix.2_Missense_Mutation_p.A289T|DNAJC2_uc003vbp.2_5'UTR	NM_014377	NP_055192	Q99543	DNJC2_HUMAN	DnaJ (Hsp40) homolog, subfamily C, member 2	289					'de novo' cotranslational protein folding|chromatin modification|positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytosol|nuclear membrane	chromatin binding|DNA binding|histone binding|Hsp70 protein binding|ubiquitin binding			kidney(1)	1						tctttcttggctttttcttct	0.169			NA											13	18					0	0	0.00010058	0	0
LAMB4	22798	broad.mit.edu	37	7	107708461	107708461	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:107708461G>C	uc010ljo.1	-	19	2530	c.2446C>G	c.(2446-2448)CCA>GCA	p.P816A	LAMB4_uc003vey.2_Missense_Mutation_p.P816A	NM_007356	NP_031382	A4D0S4	LAMB4_HUMAN	laminin, beta 4 precursor	816	Laminin EGF-like 6.				cell adhesion	basement membrane				ovary(4)|breast(2)|large_intestine(1)|skin(1)	8						TGCTACGTACGGTGACAGCCG	0.527			NA											8	341					0	0	6.40141e-05	0	0
DOCK4	9732	broad.mit.edu	37	7	111535745	111535745	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:111535745C>A	uc003vfx.2	-	16	1779	c.1510G>T	c.(1510-1512)GGG>TGG	p.G504W	DOCK4_uc003vfy.2_Missense_Mutation_p.G504W|DOCK4_uc003vga.1_Missense_Mutation_p.G109W	NM_014705	NP_055520	Q8N1I0	DOCK4_HUMAN	dedicator of cytokinesis 4	504	DHR-1.				cell chemotaxis	cytosol|endomembrane system|membrane|stereocilium	GTP binding|guanyl-nucleotide exchange factor activity|PDZ domain binding|Rac GTPase activator activity|Rac GTPase binding|receptor tyrosine kinase binding|SH3 domain binding			ovary(2)|haematopoietic_and_lymphoid_tissue(1)|central_nervous_system(1)	4		Acute lymphoblastic leukemia(1;0.0441)				AAAGAAAACCCAAACAACTTC	0.398			NA											11	341					0.000219431	0.00454042	0.000219431	1	0
FOXP2	93986	broad.mit.edu	37	7	114304371	114304371	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:114304371G>T	uc003vhb.2	+	16	2257	c.1883G>T	c.(1882-1884)GGA>GTA	p.G628V	FOXP2_uc003vgu.2_RNA|FOXP2_uc003vgz.2_Missense_Mutation_p.G653V|FOXP2_uc003vha.2_Missense_Mutation_p.G536V|FOXP2_uc011kmu.1_Missense_Mutation_p.G645V|FOXP2_uc011kmv.1_Missense_Mutation_p.G627V|FOXP2_uc010ljz.1_Missense_Mutation_p.G443V	NM_014491	NP_055306	O15409	FOXP2_HUMAN	forkhead box P2 isoform I	628					camera-type eye development|caudate nucleus development|cerebellum development|cerebral cortex development|embryo development|growth|lung alveolus development|negative regulation of transcription, DNA-dependent|pattern specification process|positive regulation of epithelial cell proliferation involved in lung morphogenesis|positive regulation of mesenchymal cell proliferation|post-embryonic development|putamen development|regulation of sequence-specific DNA binding transcription factor activity|righting reflex|skeletal muscle tissue development|smooth muscle tissue development|vocal learning	cytoplasm|transcription factor complex	chromatin binding|DNA bending activity|double-stranded DNA binding|promoter binding|protein heterodimerization activity|protein homodimerization activity|sequence-specific DNA binding|sequence-specific enhancer binding RNA polymerase II transcription factor activity|specific RNA polymerase II transcription factor activity|specific transcriptional repressor activity|transcription activator activity|transcription factor binding|zinc ion binding			ovary(4)|pancreas(1)|lung(1)|breast(1)|skin(1)	8						AGTAATCCTGGACTGATAAAT	0.423			NA											27	43					1.13719e-10	2.61668e-09	0.000227799	1	0
CFTR	1080	broad.mit.edu	37	7	117267710	117267710	+	Missense_Mutation	SNP	T	T	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:117267710T>A	uc003vjd.2	+	22	3735	c.3603T>A	c.(3601-3603)GAT>GAA	p.D1201E	CFTR_uc011knq.1_Missense_Mutation_p.D607E	NM_000492	NP_000483	P13569	CFTR_HUMAN	cystic fibrosis transmembrane conductance	1201	Cytoplasmic (Potential).				respiratory gaseous exchange	apical plasma membrane|basolateral plasma membrane|chloride channel complex|early endosome membrane	ATP binding|ATP-binding and phosphorylation-dependent chloride channel activity|channel-conductance-controlling ATPase activity|chloride channel regulator activity|enzyme binding|PDZ domain binding			central_nervous_system(2)|skin(2)|ovary(1)	5	Lung NSC(10;0.00148)|all_lung(10;0.00171)		STAD - Stomach adenocarcinoma(10;0.000534)		Bumetanide(DB00887)|Glibenclamide(DB01016)	TGAAGAAAGATGACATCTGGC	0.408			NA							Cystic_Fibrosis				22	41					0	0	0.000375601	0	0
CTTNBP2	83992	broad.mit.edu	37	7	117375073	117375073	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:117375073G>C	uc003vjf.2	-	16	3862	c.3770C>G	c.(3769-3771)TCC>TGC	p.S1257C		NM_033427	NP_219499	Q8WZ74	CTTB2_HUMAN	cortactin binding protein 2	1257										ovary(4)|central_nervous_system(1)	5	Lung NSC(10;0.0018)|all_lung(10;0.002)			LUSC - Lung squamous cell carcinoma(290;0.133)		CAGCAAGTCGGAGCCCTGGAG	0.527			NA											15	20					0	0	5.01169e-05	0	0
AASS	10157	broad.mit.edu	37	7	121717923	121717923	+	Silent	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:121717923G>C	uc003vka.2	-	22	2727	c.2631C>G	c.(2629-2631)CCC>CCG	p.P877P	AASS_uc011knu.1_RNA|AASS_uc011knv.1_RNA|AASS_uc003vkb.2_Silent_p.P877P|AASS_uc011knw.1_Silent_p.P365P	NM_005763	NP_005754	Q9UDR5	AASS_HUMAN	aminoadipate-semialdehyde synthase precursor	877	Saccharopine dehydrogenase.				protein tetramerization	mitochondrial matrix	binding|saccharopine dehydrogenase (NAD+, L-glutamate-forming) activity|saccharopine dehydrogenase (NADP+, L-lysine-forming) activity			upper_aerodigestive_tract(1)|ovary(1)	2					L-Glutamic Acid(DB00142)|NADH(DB00157)	CCATGGCGGTGGGTAACCCCA	0.463			NA											6	276					0	0	8.12818e-05	0	0
FLNC	2318	broad.mit.edu	37	7	128478663	128478663	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:128478663G>A	uc003vnz.3	+	8	1426	c.1217G>A	c.(1216-1218)GGC>GAC	p.G406D	FLNC_uc003voa.3_Missense_Mutation_p.G406D	NM_001458	NP_001449	Q14315	FLNC_HUMAN	gamma filamin isoform a	406	Filamin 2.				cell junction assembly	cytoskeleton|cytosol|plasma membrane|sarcomere	actin binding			breast(5)|large_intestine(3)|ovary(2)|central_nervous_system(1)|skin(1)	12						GCAGGGGCCGGCACTGGCGAT	0.667			NA											36	62					0	0	0.000374591	0	0
NRF1	4899	broad.mit.edu	37	7	129348936	129348937	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:129348936_129348937CC>AA	uc003voz.2	+	6	745_746	c.628_629CC>AA	c.(628-630)CCA>AAA	p.P210K	NRF1_uc003vpa.2_Missense_Mutation_p.P210K|NRF1_uc011kpa.1_Missense_Mutation_p.P49K|NRF1_uc003vpb.2_Missense_Mutation_p.P210K	NM_005011	NP_005002	Q16656	NRF1_HUMAN	nuclear respiratory factor 1	210					generation of precursor metabolites and energy|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	nucleus	DNA binding			ovary(1)	1						GGCATTTATCCCAGAGATGCTC	0.49			NA											11	480					0	0	6.4e-05	0	0
PLXNA4	91584	broad.mit.edu	37	7	131864552	131864552	+	Silent	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:131864552C>A	uc003vra.3	-	20	3997	c.3768G>T	c.(3766-3768)GTG>GTT	p.V1256V		NM_020911	NP_065962	Q9HCM2	PLXA4_HUMAN	plexin A4 isoform 1	1256	Helical; (Potential).					integral to membrane|intracellular|plasma membrane				ovary(1)	1						AGGCAATGAGCACGGCCACGA	0.617			NA											10	19					5.50884e-06	0.000120511	0.00010058	1	0
KIAA1549	57670	broad.mit.edu	37	7	138603427	138603427	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:138603427C>G	uc011kql.1	-	2	994	c.945G>C	c.(943-945)TGG>TGC	p.W315C	KIAA1549_uc003vuk.3_Missense_Mutation_p.W265C|KIAA1549_uc011kqj.1_Missense_Mutation_p.W315C	NM_020910	NP_065961	Q9HCM3	K1549_HUMAN	hypothetical protein LOC57670 isoform 1	315						integral to membrane			KIAA1549/BRAF(229)	central_nervous_system(229)|pancreas(1)	230						CACTTGTGGCCCAAACCTCCT	0.522	NSCLC(119;1534 1718 44213 46230 50068)		NA	O	BRAF	pilocytic astrocytoma								30	53					0	0	0.000147802	0	0
MGAM	8972	broad.mit.edu	37	7	141800678	141800678	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:141800678G>T	uc003vwy.2	+	45	5317	c.5263G>T	c.(5263-5265)GGG>TGG	p.G1755W		NM_004668	NP_004659	O43451	MGA_HUMAN	maltase-glucoamylase	1755	Glucoamylase.|Lumenal (Potential).				polysaccharide digestion|starch catabolic process	apical plasma membrane|integral to membrane	carbohydrate binding|glucan 1,4-alpha-glucosidase activity|maltose alpha-glucosidase activity			ovary(2)	2	Melanoma(164;0.0272)				Acarbose(DB00284)|Miglitol(DB00491)|Voglibose(DB04878)	CTGGGATGATGGGCAAAGCAT	0.502			NA											9	11					9.70103e-10	2.20638e-08	3.86212e-05	1	0
PRSS1	5644	broad.mit.edu	37	7	142459785	142459785	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:142459785G>A	uc003wak.2	+	3	378	c.361G>A	c.(361-363)GCC>ACC	p.A121T	uc011krr.1_Intron|uc003vzp.2_Intron|uc011ksh.1_Intron|uc011ksi.1_Intron|uc003vzw.1_Intron|uc010loj.1_Intron|uc003wad.2_Intron|uc003wag.1_Intron|TRY6_uc011ksn.1_Intron|PRSS1_uc011ksm.1_3'UTR|PRSS1_uc003wam.2_Missense_Mutation_p.A61T	NM_002769	NP_002760	P07477	TRY1_HUMAN	protease, serine, 1 preproprotein	121	Peptidase S1.				digestion|proteolysis	extracellular space	metal ion binding|protein binding|serine-type endopeptidase activity			large_intestine(1)|central_nervous_system(1)	2	Melanoma(164;0.047)	all_cancers(3;2.14e-49)|Acute lymphoblastic leukemia(3;7.3e-185)|all_hematologic(3;1.1e-165)	all cancers(2;0.000126)|Colorectal(2;0.000157)|Epithelial(2;0.000191)|COAD - Colon adenocarcinoma(2;0.00189)			AGTAATCAACGCCCGCGTGTC	0.572			NA							Hereditary_Pancreatitis				55	67					0	0	0.000147903	0	0
CNTNAP2	26047	broad.mit.edu	37	7	148112658	148112658	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:148112658C>T	uc003weu.1	+	24	4462	c.3946C>T	c.(3946-3948)CCC>TCC	p.P1316S	CNTNAP2_uc003wev.1_Missense_Mutation_p.P93S	NM_014141	NP_054860	Q9UHC6	CNTP2_HUMAN	cell recognition molecule Caspr2 precursor	1316	Cytoplasmic (Potential).				behavior|cell adhesion|clustering of voltage-gated potassium channels|limbic system development|neuron recognition|signal transduction|striatum development|superior temporal gyrus development|thalamus development|transmission of nerve impulse	axolemma|cell body fiber|dendrite|juxtaparanode region of axon|voltage-gated potassium channel complex	receptor binding			ovary(9)|central_nervous_system(1)|pancreas(1)	11	Melanoma(164;0.153)	all_cancers(3;3.51e-10)|all_epithelial(3;1.4e-05)|Myeloproliferative disorder(3;0.00452)|Lung NSC(3;0.0067)|all_lung(3;0.00794)	OV - Ovarian serous cystadenocarcinoma(82;0.0319)			GAACAACGACCCCAACTTCAC	0.547			NA								HNSCC(39;0.1)			32	64					0	0	0.000191422	0	0
ABP1	26	broad.mit.edu	37	7	150555928	150555928	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:150555928G>A	uc003why.1	+	4	5866	c.1648G>A	c.(1648-1650)GTC>ATC	p.V550I	ABP1_uc003whz.1_Missense_Mutation_p.V550I|ABP1_uc003wia.1_Missense_Mutation_p.V550I	NM_001091	NP_001082	P19801	ABP1_HUMAN	amiloride binding protein 1 precursor	550					amine metabolic process	extracellular space|peroxisome	copper ion binding|diamine oxidase activity|heparin binding|histamine oxidase activity|methylputrescine oxidase activity|primary amine oxidase activity|propane-1,3-diamine oxidase activity|quinone binding			ovary(2)|breast(2)|skin(2)	6	all_neural(206;0.219)		OV - Ovarian serous cystadenocarcinoma(82;0.0121)	UCEC - Uterine corpus endometrioid carcinoma (81;0.168)	Amiloride(DB00594)|Spermine(DB00127)	ACACCGCGTGGTCCAGCCAAC	0.577	Pancreas(195;1227 3054 24912 28503)		NA											19	31					0	0	0.000229342	0	0
MYOM2	9172	broad.mit.edu	37	8	2092878	2092878	+	Silent	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr8:2092878C>A	uc003wpx.3	+	37	4509	c.4371C>A	c.(4369-4371)CCC>CCA	p.P1457P	MYOM2_uc011kwi.1_Silent_p.P882P	NM_003970	NP_003961	P54296	MYOM2_HUMAN	myomesin 2	1457					muscle contraction	myosin filament	structural constituent of muscle			ovary(4)|central_nervous_system(1)|skin(1)	6		Ovarian(12;0.0572)|Colorectal(14;0.0844)|Hepatocellular(245;0.217)		BRCA - Breast invasive adenocarcinoma(11;1.85e-05)|Colorectal(4;0.0101)|READ - Rectum adenocarcinoma(4;0.148)|COAD - Colon adenocarcinoma(4;0.179)		AGCTCATCCCCGCGTCTGCCT	0.582			NA											16	22					6.31663e-08	1.41328e-06	0.000308642	1	0
CSMD1	64478	broad.mit.edu	37	8	3165290	3165290	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr8:3165290C>A	uc011kwk.1	-	25	4270	c.3880G>T	c.(3880-3882)GGC>TGC	p.G1294C	CSMD1_uc011kwj.1_Missense_Mutation_p.G686C|CSMD1_uc003wqe.2_Missense_Mutation_p.G450C	NM_033225	NP_150094	Q96PZ7	CSMD1_HUMAN	CUB and Sushi multiple domains 1 precursor	1294	Extracellular (Potential).|CUB 8.					integral to membrane				breast(20)|large_intestine(5)	25		all_cancers(1;5.7e-41)|all_epithelial(1;2.54e-36)|Lung NSC(1;7.54e-11)|all_lung(1;3.2e-10)|Hepatocellular(1;3.78e-05)|Breast(1;0.000196)|Myeloproliferative disorder(4;0.000374)|Esophageal squamous(1;0.0157)|Ovarian(12;0.091)|Renal(68;0.144)|Colorectal(14;0.234)		all cancers(1;5.03e-41)|Epithelial(1;4.78e-31)|Lung(1;1.14e-14)|LUSC - Lung squamous cell carcinoma(1;2.34e-14)|GBM - Glioblastoma multiforme(1;4.49e-10)|Colorectal(4;1.18e-07)|OV - Ovarian serous cystadenocarcinoma(1;3.2e-07)|BRCA - Breast invasive adenocarcinoma(1;6.17e-07)|COAD - Colon adenocarcinoma(4;0.000539)|READ - Rectum adenocarcinoma(4;0.00896)|Kidney(5;0.00957)|KIRC - Kidney renal clear cell carcinoma(5;0.0689)		GCTGGATAGCCAGGGGACAAT	0.483			NA											8	160					1.12685e-05	0.000244952	0.000274275	1	0
Unknown	0	broad.mit.edu	37	8	7806690	7806690	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr8:7806690C>G	uc010lro.1	+	4	334	c.52C>G	c.(52-54)CAG>GAG	p.Q18E		NM_001039615	NP_001034704			zinc finger protein 705D												NA						TGACTTCACCCAGGAAGAGTG	0.428			NA											74	22					0	0	0.000147903	0	0
MTMR7	9108	broad.mit.edu	37	8	17157580	17157580	+	Missense_Mutation	SNP	G	G	C	rs140365611		TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr8:17157580G>C	uc003wxm.2	-	14	2013	c.1774C>G	c.(1774-1776)CGG>GGG	p.R592G	MTMR7_uc011kya.1_Missense_Mutation_p.R226G|MTMR7_uc011kyb.1_Missense_Mutation_p.R183G	NM_004686	NP_004677	Q9Y216	MTMR7_HUMAN	myotubularin related protein 7	592							protein tyrosine phosphatase activity			skin(1)	1				Colorectal(111;0.112)		GAAGGGCTCCGGGATGGAAAT	0.478			NA											4	158					0	0	8.12818e-05	0	0
CCDC25	55246	broad.mit.edu	37	8	27610105	27610105	+	Splice_Site	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr8:27610105C>G	uc003xgc.2	-	5	282	c.169_splice	c.e5-1	p.G57_splice	CCDC25_uc003xgd.2_Splice_Site|CCDC25_uc011lan.1_Splice_Site|CCDC25_uc011lao.1_Splice_Site|CCDC25_uc003xge.2_Splice_Site|CCDC25_uc003xgf.1_Splice_Site	NM_018246	NP_060716	Q86WR0	CCD25_HUMAN	coiled-coil domain containing 25												0		Ovarian(32;0.000953)		UCEC - Uterine corpus endometrioid carcinoma (27;0.0223)|KIRC - Kidney renal clear cell carcinoma(542;0.11)|Kidney(114;0.131)|Colorectal(74;0.154)		TATTCTCTCCCTGAAACACAA	0.428			NA											4	48					0	0	1.23904e-05	0	0
PCMTD1	115294	broad.mit.edu	37	8	52733173	52733173	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr8:52733173C>A	uc003xqx.3	-	6	1153	c.812G>T	c.(811-813)AGG>ATG	p.R271M	PCMTD1_uc011ldm.1_Missense_Mutation_p.R141M|PCMTD1_uc003xqw.3_Missense_Mutation_p.R271M|PCMTD1_uc011ldn.1_Missense_Mutation_p.R83M|PCMTD1_uc010lya.2_Missense_Mutation_p.R195M	NM_052937	NP_443169	Q96MG8	PCMD1_HUMAN	protein-L-isoaspartate (D-aspartate)	271						cytoplasm	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity				0		Lung NSC(129;0.0795)|all_lung(136;0.144)				GGGTGGAGCCCTTTGAGGAAT	0.408			NA											10	198					1.49906e-05	0.000324325	0.000219431	1	0
PENK	5179	broad.mit.edu	37	8	57353976	57353976	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr8:57353976G>C	uc003xsz.2	-	2	740	c.659C>G	c.(658-660)CCA>CGA	p.P220R	PENK_uc003xta.3_Missense_Mutation_p.P220R	NM_006211	NP_006202	P01210	PENK_HUMAN	proenkephalin	220					neuropeptide signaling pathway	extracellular region	neuropeptide hormone activity|opioid peptide activity			ovary(2)|central_nervous_system(1)|skin(1)	4		all_lung(136;0.229)	Epithelial(17;0.000873)|all cancers(17;0.0069)			CCACCACTCTGGGCGACCTAC	0.537			NA											4	137					0	0	3.59834e-05	0	0
RAB2A	5862	broad.mit.edu	37	8	61496839	61496839	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr8:61496839G>T	uc003xud.1	+	4	467	c.259G>T	c.(259-261)GAT>TAT	p.D87Y	RAB2A_uc011lef.1_Missense_Mutation_p.D63Y	NM_002865	NP_002856	P61019	RAB2A_HUMAN	RAB2A, member RAS oncogene family	87					ER to Golgi vesicle-mediated transport|protein transport|small GTPase mediated signal transduction	endoplasmic reticulum membrane|ER-Golgi intermediate compartment membrane|Golgi membrane|melanosome	GDP binding|GTP binding|GTPase activity				0			BRCA - Breast invasive adenocarcinoma(89;0.0805)			ACTAGTTTACGATATTACACG	0.378			NA											62	94					1.34159e-35	3.50957e-34	0.000147903	1	0
CRISPLD1	83690	broad.mit.edu	37	8	75929613	75929613	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr8:75929613G>T	uc003yan.2	+	10	1430	c.1055G>T	c.(1054-1056)TGG>TTG	p.W352L	CRISPLD1_uc011lfk.1_Missense_Mutation_p.W164L|CRISPLD1_uc011lfl.1_Missense_Mutation_p.W164L	NM_031461	NP_113649	Q9H336	CRLD1_HUMAN	cysteine-rich secretory protein LCCL domain	352	LCCL 1.					extracellular region				ovary(1)|central_nervous_system(1)	2	Breast(64;0.0799)		Epithelial(68;0.155)|BRCA - Breast invasive adenocarcinoma(89;0.161)			GATGGTGGCTGGGTAGATATC	0.338			NA											89	134					2.56585e-57	6.84226e-56	0.000147903	1	0
CDH17	1015	broad.mit.edu	37	8	95183133	95183133	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr8:95183133C>G	uc003ygh.2	-	8	989	c.864G>C	c.(862-864)CAG>CAC	p.Q288H	CDH17_uc011lgo.1_Intron|CDH17_uc011lgp.1_Missense_Mutation_p.Q288H	NM_004063	NP_004054	Q12864	CAD17_HUMAN	cadherin 17 precursor	288	Extracellular (Potential).|Cadherin 3.					integral to membrane	calcium ion binding			ovary(5)|skin(1)	6	Breast(36;4.65e-06)		BRCA - Breast invasive adenocarcinoma(8;0.00691)			TATCTCCTTCCTGGTCAATTG	0.468			NA											5	196					0	0	1.23904e-05	0	0
DPYS	1807	broad.mit.edu	37	8	105441832	105441832	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr8:105441832C>G	uc003yly.3	-	5	1020	c.891G>C	c.(889-891)ATG>ATC	p.M297I		NM_001385	NP_001376	Q14117	DPYS_HUMAN	dihydropyrimidinase	297					protein homotetramerization|pyrimidine nucleoside catabolic process|thymine catabolic process|uracil catabolic process	cytosol	dihydropyrimidinase activity|zinc ion binding			upper_aerodigestive_tract(1)|ovary(1)	2			OV - Ovarian serous cystadenocarcinoma(57;1.61e-06)|STAD - Stomach adenocarcinoma(118;0.229)			AAGGTGGACCCATGACATGGT	0.502			NA											4	70					0	0	0.00024832	0	0
SYBU	55638	broad.mit.edu	37	8	110592123	110592123	+	Silent	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr8:110592123C>T	uc003ynj.3	-	5	802	c.639G>A	c.(637-639)CTG>CTA	p.L213L	SYBU_uc003yni.3_Silent_p.L210L|SYBU_uc003ynk.3_Silent_p.L94L|SYBU_uc010mco.2_Silent_p.L212L|SYBU_uc003ynl.3_Silent_p.L212L|SYBU_uc010mcp.2_Silent_p.L213L|SYBU_uc010mcq.2_Silent_p.L213L|SYBU_uc003yno.3_Silent_p.L94L|SYBU_uc010mcr.2_Silent_p.L213L|SYBU_uc003ynm.3_Silent_p.L212L|SYBU_uc003ynn.3_Silent_p.L212L|SYBU_uc010mcs.2_Silent_p.L94L|SYBU_uc010mct.2_Silent_p.L213L|SYBU_uc010mcu.2_Silent_p.L212L|SYBU_uc003ynp.3_Silent_p.L145L|SYBU_uc010mcv.2_Silent_p.L213L|SYBU_uc003ynh.3_Silent_p.L7L|SYBU_uc011lhw.1_Silent_p.L83L	NM_001099754	NP_001093224	Q9NX95	SYBU_HUMAN	Golgi-localized syntaphilin-related protein	213	Sufficient for interaction with KIF5B.|Ser-rich.					cytoplasmic membrane-bounded vesicle|cytoskeleton|Golgi membrane|integral to membrane				ovary(1)	1						TGACAGGGCTCAGCTGATTCC	0.552			NA											72	120					0	0	0.000147903	0	0
CSMD3	114788	broad.mit.edu	37	8	113253965	113253965	+	Silent	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr8:113253965G>C	uc003ynu.2	-	66	10611	c.10452C>G	c.(10450-10452)CCC>CCG	p.P3484P	CSMD3_uc003yns.2_Silent_p.P2686P|CSMD3_uc003ynt.2_Silent_p.P3444P|CSMD3_uc011lhx.1_Silent_p.P3315P	NM_198123	NP_937756	Q7Z407	CSMD3_HUMAN	CUB and Sushi multiple domains 3 isoform 1	3484	Extracellular (Potential).					integral to membrane|plasma membrane				ovary(21)|lung(11)|skin(11)|kidney(8)|large_intestine(6)|upper_aerodigestive_tract(2)|central_nervous_system(2)|urinary_tract(1)|breast(1)	63						GCTTTGGGCTGGGTGTTCCCA	0.318			NA								HNSCC(6;0.00088)|TCGA Ovarian(7;0.080)			5	221					0	0	0.000157383	0	0
TRPS1	7227	broad.mit.edu	37	8	116631852	116631852	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr8:116631852C>G	uc003ynz.2	-	2	893	c.434G>C	c.(433-435)GGG>GCG	p.G145A	TRPS1_uc011lhy.1_Missense_Mutation_p.G149A|TRPS1_uc003yny.2_Missense_Mutation_p.G158A|TRPS1_uc010mcy.2_Missense_Mutation_p.G145A	NM_014112	NP_054831	Q9UHF7	TRPS1_HUMAN	zinc finger transcription factor TRPS1	145					negative regulation of transcription from RNA polymerase II promoter|NLS-bearing substrate import into nucleus|regulation of chondrocyte differentiation|skeletal system development|transcription from RNA polymerase II promoter	nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			ovary(2)|skin(2)|pancreas(1)|lung(1)|kidney(1)	7	all_cancers(13;5.44e-23)|all_epithelial(1;2.14e-27)|Lung NSC(37;2.55e-05)|Ovarian(258;0.0219)		Epithelial(1;9.78e-37)|all cancers(1;3.14e-31)|BRCA - Breast invasive adenocarcinoma(1;2.56e-12)			CAGTGAGTCCCCTGAGGGGGT	0.537			NA							Langer-Giedion_syndrome				4	96					0	0	0.00024832	0	0
TNFRSF11B	4982	broad.mit.edu	37	8	119945315	119945315	+	Silent	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr8:119945315G>C	uc003yon.3	-	2	578	c.255C>G	c.(253-255)CCC>CCG	p.P85P	TNFRSF11B_uc010mdc.1_RNA	NM_002546	NP_002537	O00300	TR11B_HUMAN	osteoprotegerin precursor	85	TNFR-Cys 2.				apoptosis|skeletal system development		cytokine activity|receptor activity			central_nervous_system(2)	2	all_cancers(13;3.71e-26)|Lung NSC(37;1.69e-07)|Ovarian(258;0.018)|all_neural(195;0.0592)|Hepatocellular(40;0.234)		STAD - Stomach adenocarcinoma(47;0.00193)			CCTTGCACACGGGGCTGCAGT	0.562			NA											4	89					0	0	1.23904e-05	0	0
FER1L6	654463	broad.mit.edu	37	8	125022894	125022894	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr8:125022894G>T	uc003yqw.2	+	14	1967	c.1761G>T	c.(1759-1761)TGG>TGT	p.W587C	uc003yqx.1_Intron	NM_001039112	NP_001034201	Q2WGJ9	FR1L6_HUMAN	fer-1-like 6	587	Cytoplasmic (Potential).					integral to membrane				ovary(5)|skin(5)|central_nervous_system(1)	11	Lung NSC(37;4.1e-12)|Ovarian(258;0.00438)|all_neural(195;0.0741)		STAD - Stomach adenocarcinoma(47;0.00186)			TCAGCTCTTGGGGAGACCAGA	0.458			NA											10	242					0.00010058	0.00210972	0.00010058	1	0
KHDRBS3	10656	broad.mit.edu	37	8	136561009	136561009	+	Silent	SNP	A	A	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr8:136561009A>C	uc003yuv.2	+	4	731	c.337A>C	c.(337-339)AGG>CGG	p.R113R	KHDRBS3_uc003yuw.2_Silent_p.R113R	NM_006558	NP_006549	O75525	KHDR3_HUMAN	KH domain containing, RNA binding, signal	113	KH.				regulation of transcription, DNA-dependent|spermatogenesis|transcription, DNA-dependent	nucleus	SH3 domain binding			ovary(2)	2	all_epithelial(106;2.85e-16)|all_neural(2;2.72e-06)|Lung NSC(106;3.95e-06)|all_lung(105;1.11e-05)|Ovarian(258;0.00579)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.247)			AGAAGAGTTGAGGAAAAGTGG	0.358			NA											13	23					0	0	0.000308642	0	0
COL22A1	169044	broad.mit.edu	37	8	139629183	139629183	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr8:139629183C>A	uc003yvd.2	-	54	4291	c.3844G>T	c.(3844-3846)GGC>TGC	p.G1282C	COL22A1_uc011ljo.1_Missense_Mutation_p.G562C	NM_152888	NP_690848	Q8NFW1	COMA1_HUMAN	collagen, type XXII, alpha 1	1282	Pro-rich.|Gly-rich.|Collagen-like 12.				cell adhesion	collagen|cytoplasm	structural molecule activity			ovary(11)|pancreas(1)|skin(1)	13	all_epithelial(106;1.55e-12)|Lung NSC(106;1.67e-05)|all_lung(105;3.39e-05)|Ovarian(258;0.00672)|Acute lymphoblastic leukemia(118;0.155)		BRCA - Breast invasive adenocarcinoma(115;0.0517)			CCAGAATCGCCTGTGTGTCCC	0.577			NA								HNSCC(7;0.00092)			18	33					1.96292e-10	4.49415e-09	0.000175454	1	0
BAI1	575	broad.mit.edu	37	8	143623435	143623435	+	Silent	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr8:143623435G>T	uc003ywm.2	+	27	4023	c.3840G>T	c.(3838-3840)CCG>CCT	p.P1280P		NM_001702	NP_001693	O14514	BAI1_HUMAN	brain-specific angiogenesis inhibitor 1	1280	Cytoplasmic (Potential).				axonogenesis|cell adhesion|negative regulation of angiogenesis|negative regulation of cell proliferation|neuropeptide signaling pathway|peripheral nervous system development	cell-cell junction|integral to plasma membrane	G-protein coupled receptor activity|protein binding			lung(3)|ovary(2)|breast(1)|central_nervous_system(1)|pancreas(1)	8	all_cancers(97;2.84e-12)|all_epithelial(106;5.91e-09)|Lung NSC(106;0.000322)|all_lung(105;0.000616)|Medulloblastoma(13;0.00276)|all_neural(13;0.00559)|Ovarian(258;0.0315)|Acute lymphoblastic leukemia(118;0.155)					ACAGCCTGCCGGCCAACGTGT	0.662			NA											7	14					3.86212e-05	0.000822643	3.86212e-05	1	0
ZNF623	9831	broad.mit.edu	37	8	144733268	144733268	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr8:144733268G>T	uc003yzd.2	+	1	1315	c.1226G>T	c.(1225-1227)GGG>GTG	p.G409V	ZNF623_uc011lkp.1_Missense_Mutation_p.G369V|ZNF623_uc003yzc.2_Missense_Mutation_p.G369V	NM_014789	NP_055604	O75123	ZN623_HUMAN	zinc finger protein 623 isoform 1	409	C2H2-type 11.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding				0	all_cancers(97;3.74e-11)|all_epithelial(106;2.62e-09)|Lung NSC(106;0.00013)|all_lung(105;0.000374)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;5.28e-40)|all cancers(56;5.23e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.146)			AAGGAATGTGGGAAAGCGTTT	0.468			NA											19	49					6.44725e-10	1.46878e-08	0.000295444	1	0
EPPK1	83481	broad.mit.edu	37	8	144940387	144940387	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr8:144940387C>G	uc003zaa.1	-	2	15058	c.15045G>C	c.(15043-15045)ACG>ACC	p.T5015T		NM_031308	NP_112598	P58107	EPIPL_HUMAN	epiplakin 1	5015	Plectin 64.					cytoplasm|cytoskeleton	protein binding|structural molecule activity			pancreas(1)|skin(1)	2	all_cancers(97;1.42e-10)|all_epithelial(106;1.99e-09)|Lung NSC(106;0.000126)|all_lung(105;0.000354)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;2.46e-41)|Epithelial(56;2.88e-40)|all cancers(56;1.82e-35)|Colorectal(110;0.055)|BRCA - Breast invasive adenocarcinoma(115;0.105)			TGACGCCGCCCGTGGCGATCT	0.692			NA											6	275					0	0	8.12818e-05	0	0
GPR172A	79581	broad.mit.edu	37	8	145583397	145583398	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr8:145583397_145583398GG>TT	uc003zcc.1	+	3	402_403	c.245_246GG>TT	c.(244-246)CGG>CTT	p.R82L	FBXL6_uc003zbz.2_5'Flank|FBXL6_uc003zca.2_5'Flank|FBXL6_uc003zcb.2_5'Flank|FBXL6_uc010mfx.2_5'Flank|GPR172A_uc003zcd.1_Missense_Mutation_p.R82L|GPR172A_uc003zce.1_Missense_Mutation_p.R82L|GPR172A_uc010mfy.1_Missense_Mutation_p.R82L|GPR172A_uc003zcf.1_Missense_Mutation_p.R82L|GPR172A_uc011llc.1_5'UTR	NM_024531	NP_078807	Q9HAB3	RFT3_HUMAN	G protein-coupled receptor 172A precursor	82						integral to plasma membrane	receptor activity|riboflavin transporter activity				0	all_cancers(97;6.64e-12)|all_epithelial(106;2.89e-10)|Lung NSC(106;5.7e-05)|all_lung(105;0.000174)|Ovarian(258;0.0173)|Acute lymphoblastic leukemia(118;0.155)		OV - Ovarian serous cystadenocarcinoma(54;4.43e-40)|Epithelial(56;1.48e-39)|all cancers(56;1.49e-34)|BRCA - Breast invasive adenocarcinoma(115;0.0441)|Colorectal(110;0.055)			GTCCCCATCCGGGTGGTGCAGG	0.634			NA											32	29					0	0	6.4e-05	0	0
KIAA2026	158358	broad.mit.edu	37	9	5924840	5924840	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr9:5924840C>A	uc003zjq.3	-	7	2720	c.2504G>T	c.(2503-2505)CGC>CTC	p.R835L	KIAA2026_uc010mht.2_Missense_Mutation_p.R10L	NM_001017969	NP_001017969	Q5HYC2	K2026_HUMAN	hypothetical protein LOC158358	835										ovary(2)|central_nervous_system(1)	3		Acute lymphoblastic leukemia(23;0.158)		GBM - Glioblastoma multiforme(50;0.00155)|Lung(218;0.124)		TTTCTTCAGGCGGCTCCTGAA	0.308			NA											37	25					8.73648e-17	2.11272e-15	0.000132358	1	0
CNTLN	54875	broad.mit.edu	37	9	17464545	17464545	+	Missense_Mutation	SNP	A	A	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr9:17464545A>G	uc003zmz.2	+	21	3478	c.3452A>G	c.(3451-3453)GAC>GGC	p.D1151G	CNTLN_uc003zmy.2_Missense_Mutation_p.D1152G|CNTLN_uc010mio.2_Missense_Mutation_p.D831G	NM_017738	NP_060208	Q9NXG0	CNTLN_HUMAN	centlein isoform 1	1152	Potential.					centriole|membrane	two-component sensor activity			pancreas(1)	1				GBM - Glioblastoma multiforme(50;6.14e-10)		TTGATAGAGGACTTGAAATTT	0.299			NA											107	62					0	0	0.000147903	0	0
KIAA1797	54914	broad.mit.edu	37	9	20881959	20881959	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr9:20881959C>G	uc003zog.1	+	22	2770	c.2407C>G	c.(2407-2409)CGC>GGC	p.R803G	KIAA1797_uc003zoh.1_Missense_Mutation_p.R239G	NM_017794	NP_060264	Q5VW36	K1797_HUMAN	hypothetical protein LOC54914	803						integral to membrane	binding			ovary(8)|breast(1)|kidney(1)	10				GBM - Glioblastoma multiforme(3;2.1e-125)|Lung(42;2.76e-14)|LUSC - Lung squamous cell carcinoma(42;1.99e-11)		AGGAGGTGCCCGCTCAGACCA	0.413			NA											6	106					0	0	0.000157383	0	0
TAF1L	138474	broad.mit.edu	37	9	32634374	32634374	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr9:32634374C>T	uc003zrg.1	-	1	1294	c.1204G>A	c.(1204-1206)GAG>AAG	p.E402K	uc003zrh.1_RNA	NM_153809	NP_722516	Q8IZX4	TAF1L_HUMAN	TBP-associated factor RNA polymerase 1-like	402					male meiosis|positive regulation of transcription, DNA-dependent|regulation of transcription from RNA polymerase II promoter|transcription initiation, DNA-dependent	transcription factor TFIID complex	DNA binding|histone acetyltransferase activity|protein serine/threonine kinase activity|TBP-class protein binding			lung(8)|skin(6)|central_nervous_system(4)|large_intestine(3)|ovary(2)|stomach(1)|breast(1)|pancreas(1)	26			LUSC - Lung squamous cell carcinoma(29;0.0181)	GBM - Glioblastoma multiforme(74;0.00301)		CTAAATTCCTCCATCATTCTA	0.438			NA											87	127					0	0	0.000147903	0	0
DCAF12	25853	broad.mit.edu	37	9	34098434	34098434	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr9:34098434C>G	uc003ztt.2	-	5	1025	c.683G>C	c.(682-684)CGG>CCG	p.R228P		NM_015397	NP_056212	Q5T6F0	DCA12_HUMAN	DDB1 and CUL4 associated factor 12	228						centrosome|CUL4 RING ubiquitin ligase complex					0						CACAGGGACCCGTGACACATT	0.517			NA											4	85					0	0	1.23904e-05	0	0
GRHPR	9380	broad.mit.edu	37	9	37436696	37436696	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr9:37436696C>G	uc003zzu.1	+	9	945	c.904C>G	c.(904-906)CGC>GGC	p.R302G	GRHPR_uc003zzt.1_Missense_Mutation_p.R222G|GRHPR_uc003zzw.1_Missense_Mutation_p.R159G	NM_012203	NP_036335	Q9UBQ7	GRHPR_HUMAN	glyoxylate reductase/hydroxypyruvate reductase	302					cellular nitrogen compound metabolic process|excretion|glyoxylate metabolic process	peroxisomal matrix	glycerate dehydrogenase activity|glyoxylate reductase (NADP) activity|hydroxypyruvate reductase activity|NAD binding|protein binding				0				GBM - Glioblastoma multiforme(29;0.00687)		CCACAGAACCCGCAACACCAT	0.552			NA											4	148					0	0	0.00024832	0	0
FAM75A6	389730	broad.mit.edu	37	9	43624974	43624975	+	Missense_Mutation	DNP	GG	GG	TT			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	GG	GG	-	-	GG	GG	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr9:43624974_43624975GG>TT	uc011lrb.1	-	4	3741_3742	c.3712_3713CC>AA	c.(3712-3714)CCA>AAA	p.P1238K		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	1238						integral to membrane					0						CCCACAGACTGGGGCTTGAAAC	0.5			NA											11	396					0	0	6.4e-05	0	0
DAPK1	1612	broad.mit.edu	37	9	90255752	90255752	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr9:90255752C>G	uc004apc.2	+	9	956	c.818C>G	c.(817-819)CCC>CGC	p.P273R	DAPK1_uc004ape.2_Missense_Mutation_p.P273R|DAPK1_uc004apd.2_Missense_Mutation_p.P273R|DAPK1_uc011ltg.1_Missense_Mutation_p.P273R|DAPK1_uc011lth.1_Missense_Mutation_p.P10R	NM_004938	NP_004929	P53355	DAPK1_HUMAN	death-associated protein kinase 1	273	Protein kinase.|Calmodulin-binding.				apoptosis|induction of apoptosis by extracellular signals|intracellular protein kinase cascade	actin cytoskeleton|cytoplasm	ATP binding|calmodulin binding|protein serine/threonine kinase activity			ovary(1)|breast(1)	2						TTGCAGCATCCCTGGATCAAG	0.408			NA							Chronic_Lymphocytic_Leukemia_Familial_Clustering_of				4	141					0	0	3.59834e-05	0	0
GRIN3A	116443	broad.mit.edu	37	9	104433278	104433278	+	Silent	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr9:104433278G>C	uc004bbp.1	-	3	2017	c.1416C>G	c.(1414-1416)CCC>CCG	p.P472P	GRIN3A_uc004bbq.1_Silent_p.P472P	NM_133445	NP_597702	Q8TCU5	NMD3A_HUMAN	glutamate receptor, ionotropic,	472	Extracellular (Potential).				response to ethanol	cell junction|N-methyl-D-aspartate selective glutamate receptor complex|neuron projection|neuronal cell body|outer membrane-bounded periplasmic space|postsynaptic density|postsynaptic membrane	extracellular-glutamate-gated ion channel activity|glycine binding|identical protein binding|N-methyl-D-aspartate selective glutamate receptor activity|protein phosphatase 2A binding			ovary(4)|pancreas(1)|central_nervous_system(1)|skin(1)	7		Acute lymphoblastic leukemia(62;0.0568)			Acamprosate(DB00659)|Chloroprocaine(DB01161)|Dextromethorphan(DB00514)|Ethanol(DB00898)|Ethopropazine(DB00392)|Felbamate(DB00949)|Ketamine(DB01221)|L-Glutamic Acid(DB00142)|Memantine(DB01043)|Meperidine(DB00454)|Methadone(DB00333)|Orphenadrine(DB01173)|Procaine(DB00721)|Riluzole(DB00740)	GCTTTCCCATGGGGTCATGTT	0.502			NA											6	249					0	0	0.000274275	0	0
ABCA1	19	broad.mit.edu	37	9	107578466	107578466	+	Silent	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr9:107578466C>G	uc004bcl.2	-	25	4009	c.3696G>C	c.(3694-3696)CTG>CTC	p.L1232L		NM_005502	NP_005493	O95477	ABCA1_HUMAN	ATP-binding cassette, sub-family A member 1	1232					Cdc42 protein signal transduction|cellular lipid metabolic process|cholesterol efflux|cholesterol homeostasis|cholesterol metabolic process|endosome transport|G-protein coupled receptor protein signaling pathway|high-density lipoprotein particle assembly|interleukin-1 beta secretion|intracellular cholesterol transport|lysosome organization|negative regulation of cholesterol storage|negative regulation of macrophage derived foam cell differentiation|phospholipid efflux|phospholipid homeostasis|platelet dense granule organization|positive regulation of cAMP biosynthetic process|reverse cholesterol transport	integral to plasma membrane|membrane fraction|membrane raft|phagocytic vesicle	anion transmembrane transporter activity|apolipoprotein A-I receptor activity|ATP binding|ATPase activity|cholesterol transporter activity|phospholipid transporter activity|small GTPase binding|syntaxin-13 binding			large_intestine(4)|lung(4)|ovary(4)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|skin(1)|pancreas(1)	17				OV - Ovarian serous cystadenocarcinoma(323;0.023)	Adenosine triphosphate(DB00171)|Glibenclamide(DB01016)	TAGAAATGCCCAGGTCTGAGA	0.483			NA											6	299					0	0	8.12818e-05	0	0
SLC44A1	23446	broad.mit.edu	37	9	108120644	108120644	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr9:108120644G>T	uc004bcn.2	+	7	911	c.690G>T	c.(688-690)ATG>ATT	p.M230I	SLC44A1_uc010mtk.1_Missense_Mutation_p.M230I|SLC44A1_uc004bco.1_Missense_Mutation_p.M22I	NM_080546	NP_536856	Q8WWI5	CTL1_HUMAN	CDW92 antigen	230	Helical; (Potential).					integral to membrane|mitochondrial outer membrane|plasma membrane	choline transmembrane transporter activity			breast(3)|ovary(1)	4					Choline(DB00122)	TGATTTTGATGGTGATAATCA	0.323			NA											59	90					6.70656e-16	1.61051e-14	0.000147903	1	0
IKBKAP	8518	broad.mit.edu	37	9	111693348	111693348	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr9:111693348G>C	uc004bdm.3	-	2	599	c.79C>G	c.(79-81)CGA>GGA	p.R27G	IKBKAP_uc011lwc.1_Intron|IKBKAP_uc010mtq.2_Intron	NM_003640	NP_003631	O95163	ELP1_HUMAN	inhibitor of kappa light polypeptide gene	27					immune response|protein complex assembly|regulation of transcription from RNA polymerase II promoter|transcription, DNA-dependent	cytoplasm|DNA-directed RNA polymerase II, holoenzyme|nucleolus|transcription elongation factor complex	phosphorylase kinase regulator activity|protein binding|signal transducer activity			ovary(2)|skin(2)|upper_aerodigestive_tract(1)|breast(1)|kidney(1)	7						TGTTCAGTTCGGAGAGAGAAG	0.473			NA											4	115					0	0	0.00024832	0	0
KIAA1958	158405	broad.mit.edu	37	9	115337393	115337393	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr9:115337393C>A	uc004bgf.1	+	2	1208	c.1033C>A	c.(1033-1035)CAT>AAT	p.H345N	KIAA1958_uc011lwx.1_Missense_Mutation_p.H345N	NM_133465	NP_597722	Q8N8K9	K1958_HUMAN	hypothetical protein LOC158405	345										skin(1)	1						GTTCCTGTCCCATCTGCCCAG	0.567			NA											9	119					0.000274275	0.00558288	0.000274275	1	0
ASTN2	23245	broad.mit.edu	37	9	119770371	119770371	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr9:119770371C>A	uc004bjs.1	-	7	1692	c.1591G>T	c.(1591-1593)GGA>TGA	p.G531*	ASTN2_uc004bjr.1_Nonsense_Mutation_p.G531*|ASTN2_uc004bjt.1_Nonsense_Mutation_p.G480*	NM_198187	NP_937830	O75129	ASTN2_HUMAN	astrotactin 2 isoform c	531	Extracellular (Potential).|EGF-like 1.					integral to membrane				skin(4)|ovary(3)|breast(1)|kidney(1)	9						CATGGCTCACCGGTTTCTGGG	0.557			NA											16	31					1.67942e-08	3.80078e-07	7.07596e-05	1	0
TLR4	7099	broad.mit.edu	37	9	120475790	120475790	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr9:120475790G>C	uc004bjz.2	+	3	1675	c.1384G>C	c.(1384-1386)GCT>CCT	p.A462P	TLR4_uc004bka.2_Missense_Mutation_p.A422P|TLR4_uc004bkb.2_Missense_Mutation_p.A262P	NM_138554	NP_612564	O00206	TLR4_HUMAN	toll-like receptor 4 precursor	462	Extracellular (Potential).				activation of MAPK activity|cellular response to mechanical stimulus|detection of fungus|detection of lipopolysaccharide|I-kappaB phosphorylation|innate immune response|intestinal epithelial structure maintenance|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of ERK1 and ERK2 cascade|negative regulation of interferon-gamma production|negative regulation of interleukin-17 production|negative regulation of interleukin-23 production|negative regulation of interleukin-6 production|negative regulation of osteoclast differentiation|negative regulation of tumor necrosis factor production|positive regulation of chemokine production|positive regulation of interferon-alpha production|positive regulation of interferon-beta production|positive regulation of interferon-gamma production|positive regulation of interleukin-1 production|positive regulation of interleukin-10 production|positive regulation of interleukin-12 biosynthetic process|positive regulation of interleukin-12 production|positive regulation of interleukin-6 production|positive regulation of interleukin-8 biosynthetic process|positive regulation of interleukin-8 production|positive regulation of NF-kappaB import into nucleus|positive regulation of NF-kappaB transcription factor activity|positive regulation of nitric-oxide synthase biosynthetic process|positive regulation of platelet activation|positive regulation of transcription from RNA polymerase II promoter|positive regulation of tumor necrosis factor biosynthetic process|positive regulation of tumor necrosis factor production|T-helper 1 type immune response|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	external side of plasma membrane|integral to plasma membrane|lipopolysaccharide receptor complex|perinuclear region of cytoplasm	lipopolysaccharide receptor activity|transmembrane receptor activity			lung(10)|ovary(4)|breast(1)|skin(1)	16						CACCAGAGTTGCTTTCAATGG	0.398			NA											60	80					0	0	0.000147903	0	0
MEGF9	1955	broad.mit.edu	37	9	123367659	123367659	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr9:123367659C>A	uc004bkj.1	-	8	1729	c.1729G>T	c.(1729-1731)GAG>TAG	p.E577*	MEGF9_uc011lyb.1_Nonsense_Mutation_p.E532*	NM_001080497	NP_001073966	Q9H1U4	MEGF9_HUMAN	multiple EGF-like-domains 9	540	Cytoplasmic (Potential).					integral to membrane	calcium ion binding				0						TTTTGGTACTCGCGGTACATA	0.438			NA											7	175					0.000274275	0.00558288	0.000274275	1	0
C9orf119	375757	broad.mit.edu	37	9	131039032	131039032	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr9:131039032C>G	uc004bup.2	+	2	424	c.424C>G	c.(424-426)CCT>GCT	p.P142A	GOLGA2_uc011maw.1_5'Flank|GOLGA2_uc010mxw.2_5'Flank|GOLGA2_uc004bul.1_5'Flank|C9orf119_uc010mxx.1_Missense_Mutation_p.P142A	NM_001040011	NP_001035100	Q1ZZU3	SWI5_HUMAN	hypothetical protein LOC375757	142					double-strand break repair via homologous recombination	Swi5-Sfr1 complex	protein binding				0						CTTCCGATCCCCTGTGAGTAT	0.607			NA											52	87					0	0	0.000147903	0	0
WDR34	89891	broad.mit.edu	37	9	131403138	131403138	+	Silent	SNP	C	C	T	rs137886760		TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr9:131403138C>T	uc004bvq.1	-	2	391	c.267G>A	c.(265-267)ACG>ACA	p.T89T	WDR34_uc004bvs.1_Silent_p.T89T|WDR34_uc004bvr.1_Silent_p.T89T|WDR34_uc011mbi.1_5'UTR	NM_052844	NP_443076	Q96EX3	WDR34_HUMAN	WD repeat domain 34	89						cytoplasm				central_nervous_system(2)|skin(1)	3						CGGGGGCCTCCGTCTGCACCT	0.632			NA											17	28					0	0	7.07596e-05	0	0
TSC1	7248	broad.mit.edu	37	9	135776981	135776981	+	Missense_Mutation	SNP	G	G	T	rs67005768		TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr9:135776981G>T	uc004cca.2	-	19	2731	c.2497C>A	c.(2497-2499)CAA>AAA	p.Q833K	TSC1_uc004ccb.3_Missense_Mutation_p.Q832K|TSC1_uc011mcq.1_Missense_Mutation_p.Q782K|TSC1_uc011mcr.1_Intron	NM_000368	NP_000359	Q92574	TSC1_HUMAN	tuberous sclerosis 1 protein isoform 1	833	Potential.				activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.?(1)		lung(4)|central_nervous_system(3)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|urinary_tract(1)|skin(1)|ovary(1)|bone(1)	14				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		CTTACCTTTTGGGAAACCTGA	0.458			NA	D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis		OREG0019577	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	10	244					2.17888e-05	0.000469192	0.000442599	1	0
TSC1	7248	broad.mit.edu	37	9	135786490	135786490	+	Missense_Mutation	SNP	C	C	A	rs118203490		TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr9:135786490C>A	uc004cca.2	-	11	1274	c.1040G>T	c.(1039-1041)TGG>TTG	p.W347L	TSC1_uc004ccb.3_Missense_Mutation_p.W347L|TSC1_uc011mcq.1_Missense_Mutation_p.W296L|TSC1_uc011mcr.1_Intron|TSC1_uc011mcs.1_Missense_Mutation_p.W226L|TSC1_uc004ccc.1_Missense_Mutation_p.W347L|TSC1_uc004ccd.2_3'UTR|TSC1_uc004cce.1_3'UTR	NM_000368	NP_000359	Q92574	TSC1_HUMAN	tuberous sclerosis 1 protein isoform 1	347					activation of Rho GTPase activity|cell cycle arrest|cell-matrix adhesion|insulin receptor signaling pathway|negative regulation of cell proliferation|negative regulation of protein ubiquitination|negative regulation of TOR signaling cascade|negative regulation of translation|positive regulation of focal adhesion assembly|regulation of phosphoprotein phosphatase activity|regulation of stress fiber assembly|rRNA export from nucleus	cell cortex|lamellipodium|membrane|TSC1-TSC2 complex	chaperone binding|protein N-terminus binding	p.?(1)		lung(4)|central_nervous_system(3)|breast(2)|haematopoietic_and_lymphoid_tissue(1)|urinary_tract(1)|skin(1)|ovary(1)|bone(1)	14				OV - Ovarian serous cystadenocarcinoma(145;4.32e-08)|Epithelial(140;2.72e-06)		AGATGGGCTCCAAAGAGTAGC	0.443			NA	D|Mis|N|F|S			hamartoma|renal cell			Tuberous_Sclerosis				22	579					3.10358e-05	0.00066727	0.000295444	1	0
FCN2	2220	broad.mit.edu	37	9	137772704	137772704	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr9:137772704G>T	uc004cfg.1	+	1	47	c.37G>T	c.(37-39)GCC>TCC	p.A13S	FCN2_uc004cfh.1_Missense_Mutation_p.A13S	NM_004108	NP_004099	Q15485	FCN2_HUMAN	ficolin 2 isoform a precursor	13					complement activation, lectin pathway|opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|calcium-dependent protein binding|receptor binding|sugar binding			large_intestine(1)	1		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.58e-08)|Epithelial(140;6.41e-08)|all cancers(34;3.96e-07)		CCTGGGCGCTGCCACCCTGCT	0.612			NA											16	20					1.50039e-11	3.47565e-10	0.000229342	1	0
AGPAT2	10555	broad.mit.edu	37	9	139571543	139571543	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr9:139571543C>G	uc004cii.1	-	3	464	c.362G>C	c.(361-363)CGG>CCG	p.R121P	AGPAT2_uc004cij.1_Missense_Mutation_p.R121P	NM_006412	NP_006403	O15120	PLCB_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 2	121					phosphatidic acid biosynthetic process|positive regulation of cytokine production|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity				0	all_cancers(76;0.0893)|all_epithelial(76;0.231)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.87e-06)|Epithelial(140;0.000123)		GAGCAGCTCCCGCTTGGCGAT	0.532			NA											4	69					0	0	1.23904e-05	0	0
C9orf140	89958	broad.mit.edu	37	9	139960771	139960771	+	Silent	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr9:139960771G>C	uc011men.1	-	2	743	c.627C>G	c.(625-627)CCC>CCG	p.P209P		NM_178448	NP_848543	Q86UD0	CI140_HUMAN	tumor specificity and mitosis phase-dependent	209						cytoplasm|nucleus				skin(1)	1	all_cancers(76;0.0926)	Myeloproliferative disorder(178;0.0821)	STAD - Stomach adenocarcinoma(284;0.123)	OV - Ovarian serous cystadenocarcinoma(145;3.02e-05)|Epithelial(140;0.000499)		CTCGGGCACGGGGAGCCCGCC	0.701			NA											3	16					0	0	1.23904e-05	0	0
ASMTL	8623	broad.mit.edu	37	X	1546691	1546691	+	Missense_Mutation	SNP	C	C	G			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chrX:1546691C>G	uc004cpx.1	-	7	944	c.833G>C	c.(832-834)CGG>CCG	p.R278P	ASMTL_uc011mhe.1_Missense_Mutation_p.R202P|ASMTL_uc004cpy.1_Missense_Mutation_p.R262P|ASMTL_uc011mhf.1_Missense_Mutation_p.R220P	NM_004192	NP_004183	O95671	ASML_HUMAN	acetylserotonin O-methyltransferase-like	278	ASMT-like.				melatonin biosynthetic process	cytoplasm	acetylserotonin O-methyltransferase activity				0		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				CAGGGTCTCCCGAGTCCTGTG	0.562			NA											7	134					0	0	8.12818e-05	0	0
ASMT	438	broad.mit.edu	37	X	1748724	1748724	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chrX:1748724G>C	uc004cqd.2	+	6	599	c.454G>C	c.(454-456)GAG>CAG	p.E152Q	ASMT_uc010ncy.2_Missense_Mutation_p.E152Q|ASMT_uc004cqe.2_Missense_Mutation_p.E152Q	NM_004043	NP_004034	P46597	HIOM_HUMAN	acetylserotonin O-methyltransferase	152					melatonin biosynthetic process|translation	cytosol	acetylserotonin O-methyltransferase activity|S-methyltransferase activity			skin(1)	1		all_cancers(21;4.28e-07)|all_epithelial(21;2.07e-08)|all_lung(23;2.81e-05)|Lung NSC(23;0.000693)|Lung SC(21;0.122)				GTCCGAGGGCGAGCGGCTACA	0.572			NA											4	270					0	0	1.23904e-05	0	0
NLGN4X	57502	broad.mit.edu	37	X	5821843	5821843	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chrX:5821843C>A	uc010ndh.2	-	5	1377	c.876G>T	c.(874-876)CAG>CAT	p.Q292H	NLGN4X_uc004crp.2_Missense_Mutation_p.Q312H|NLGN4X_uc004crq.2_Missense_Mutation_p.Q292H|NLGN4X_uc010ndi.2_Missense_Mutation_p.Q329H|NLGN4X_uc004crr.2_Missense_Mutation_p.Q292H|NLGN4X_uc010ndj.2_Missense_Mutation_p.Q292H	NM_181332	NP_851849	Q8N0W4	NLGNX_HUMAN	X-linked neuroligin 4 precursor	292	Extracellular (Potential).				brainstem development|cell adhesion|cell-cell junction organization|cerebellum development|male courtship behavior|positive regulation of organ growth|regulation of excitatory postsynaptic membrane potential|social behavior|synapse assembly|territorial aggressive behavior|vocalization behavior	cell surface|dendrite|integral to plasma membrane|synapse	chloride ion binding|neurexin binding|protein homodimerization activity|receptor activity			skin(2)|large_intestine(1)|ovary(1)	4						ACTTGGCCGGCTGGTAGTTCA	0.542			NA											39	9					1.00001e-27	2.56718e-26	0.000437636	1	0
DCAF8L1	139425	broad.mit.edu	37	X	27998808	27998808	+	Missense_Mutation	SNP	C	C	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chrX:27998808C>T	uc004dbx.1	-	1	759	c.644G>A	c.(643-645)GGT>GAT	p.G215D		NM_001017930	NP_001017930	A6NGE4	DC8L1_HUMAN	DDB1 and CUL4 associated factor 8-like 1	215	WD 1.									ovary(3)|skin(1)	4						TAAGTCATCACCGCTACTGGC	0.507			NA											13	2					0	0	0.000151284	0	0
USP9X	8239	broad.mit.edu	37	X	41025463	41025463	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chrX:41025463G>T	uc004dfb.2	+	16	2957	c.2324G>T	c.(2323-2325)TGG>TTG	p.W775L	USP9X_uc004dfc.2_Missense_Mutation_p.W775L	NM_001039590	NP_001034679	Q93008	USP9X_HUMAN	ubiquitin specific protease 9, X-linked isoform	775					BMP signaling pathway|cell division|chromosome segregation|female gamete generation|mitosis|protein deubiquitination|transforming growth factor beta receptor signaling pathway|ubiquitin-dependent protein catabolic process	cytoplasm	co-SMAD binding|cysteine-type endopeptidase activity|ubiquitin thiolesterase activity			lung(3)|breast(2)|ovary(1)	6						GATTACCTTTGGAGGGTAAGT	0.348	Ovarian(172;1807 2695 35459 49286)		NA											17	4					7.05477e-17	1.70904e-15	5.01169e-05	1	0
SSX3	10214	broad.mit.edu	37	X	48211539	48211539	+	Missense_Mutation	SNP	G	G	T			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chrX:48211539G>T	uc004djd.1	-	5	420	c.326C>A	c.(325-327)CCG>CAG	p.P109Q	SSX3_uc004dje.2_Missense_Mutation_p.P109Q|SSX3_uc010nic.2_Missense_Mutation_p.P109Q	NM_021014	NP_066294	Q99909	SSX3_HUMAN	synovial sarcoma, X breakpoint 3 isoform a	109					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding				0						ACTCACCTTCGGGAAGATTCC	0.443	Colon(37;227 826 19399 40970 48007)		NA											8	113					3.86212e-05	0.000822643	3.86212e-05	1	0
KDM5C	8242	broad.mit.edu	37	X	53227964	53227964	+	Nonsense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chrX:53227964C>A	uc004drz.2	-	16	2883	c.2350G>T	c.(2350-2352)GAG>TAG	p.E784*	KDM5C_uc011moc.1_RNA|KDM5C_uc011mod.1_Nonsense_Mutation_p.E717*|KDM5C_uc004dsa.2_Nonsense_Mutation_p.E783*	NM_004187	NP_004178	P41229	KDM5C_HUMAN	jumonji, AT rich interactive domain 1C isoform	784					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|protein binding|zinc ion binding			kidney(9)|ovary(5)|salivary_gland(1)|autonomic_ganglia(1)|haematopoietic_and_lymphoid_tissue(1)|oesophagus(1)	18						CGCCCATCCTCCACCTCCAGG	0.572			NA	N|F|S		clear cell renal carcinoma								43	14					1.23713e-20	3.08386e-19	0.000147903	1	0
ZXDB	158586	broad.mit.edu	37	X	57620752	57620752	+	Silent	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chrX:57620752G>C	uc004dvd.2	+	1	2484	c.2271G>C	c.(2269-2271)GCG>GCC	p.A757A		NM_007157	NP_009088	P98169	ZXDB_HUMAN	zinc finger, X-linked, duplicated B	757					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	nucleic acid binding|zinc ion binding				0						CAACCAAAGCGGAGTGGAACG	0.488			NA											3	34					0	0	6.4e-05	0	0
FAM123B	139285	broad.mit.edu	37	X	63411863	63411863	+	Missense_Mutation	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chrX:63411863C>A	uc004dvo.2	-	2	1577	c.1304G>T	c.(1303-1305)GGC>GTC	p.G435V		NM_152424	NP_689637	Q5JTC6	F123B_HUMAN	family with sequence similarity 123B	435					Wnt receptor signaling pathway	cytoplasm|nucleus|plasma membrane		p.0?(40)		kidney(99)|large_intestine(6)|ovary(3)|lung(2)|breast(1)|liver(1)	112						GAGCATGTAGCCGTGGTGGCC	0.517			NA											50	16					2.23322e-12	5.21716e-11	0.000147903	1	0
KIAA2022	340533	broad.mit.edu	37	X	73960673	73960674	+	Missense_Mutation	DNP	CC	CC	AA			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CC	CC	-	-	CC	CC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chrX:73960673_73960674CC>AA	uc004eby.2	-	3	4335_4336	c.3718_3719GG>TT	c.(3718-3720)GGC>TTC	p.G1240F		NM_001008537	NP_001008537	Q5QGS0	K2022_HUMAN	hypothetical protein LOC340533	1240					base-excision repair, gap-filling|DNA replication proofreading|DNA replication, removal of RNA primer|nucleotide-excision repair, DNA gap filling|regulation of mitotic cell cycle|S phase of mitotic cell cycle	delta DNA polymerase complex	3'-5'-exodeoxyribonuclease activity|DNA-directed DNA polymerase activity			ovary(7)|large_intestine(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	15						ACGGCCAATGCCAATTTGCATT	0.495			NA											23	8					0	0	6.4e-05	0	0
MAGT1	84061	broad.mit.edu	37	X	77150820	77150820	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chrX:77150820G>C	uc004fof.2	-	1	246	c.184C>G	c.(184-186)CAA>GAA	p.Q62E	MAGT1_uc004fog.3_RNA|MAGT1_uc004ect.3_Missense_Mutation_p.Q62E	NM_032121	NP_115497	Q9H0U3	MAGT1_HUMAN	magnesium transporter 1	30				Q -> K (in Ref. 4; BAC11592).	protein N-linked glycosylation via asparagine	integral to membrane|oligosaccharyltransferase complex				upper_aerodigestive_tract(1)	1						TTCTTTCTTTGGGCAGAGGCT	0.582			NA											3	28					0	0	6.4e-05	0	0
NXF2B	728343	broad.mit.edu	37	X	101623759	101623759	+	Silent	SNP	C	C	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chrX:101623759C>A	uc004ejb.3	-	19	2475	c.603G>T	c.(601-603)GCG>GCT	p.A201A	NXF2B_uc004eiz.3_Silent_p.A113A|NXF2B_uc004eja.3_Silent_p.A201A|NXF2_uc004eiy.3_Silent_p.A201A	NM_001099686	NP_001093156	Q9GZY0	NXF2_HUMAN	nuclear RNA export factor 2B	201	RRM.				mRNA export from nucleus|multicellular organismal development	actin cytoskeleton|cytoplasm|nuclear RNA export factor complex	nucleocytoplasmic transporter activity|nucleotide binding|RNA binding			ovary(1)	1						CAGAGTAGGGCGCAGTAGAAT	0.488			NA											19	37					1.61863e-15	3.87345e-14	0.000147903	1	0
STAG2	10735	broad.mit.edu	37	X	123217337	123217337	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chrX:123217337G>C	uc004etz.3	+	28	3330	c.2991G>C	c.(2989-2991)TTG>TTC	p.L997F	STAG2_uc004eua.2_Missense_Mutation_p.L997F|STAG2_uc004eub.2_Missense_Mutation_p.L997F|STAG2_uc004euc.2_Missense_Mutation_p.L997F|STAG2_uc004eud.2_Missense_Mutation_p.L997F|STAG2_uc004eue.2_Missense_Mutation_p.L997F	NM_006603	NP_006594	Q8N3U4	STAG2_HUMAN	stromal antigen 2 isoform b	997					cell division|meiosis|mitotic metaphase/anaphase transition|mitotic prometaphase|negative regulation of DNA endoreduplication|sister chromatid cohesion	chromatin|chromosome, centromeric region|nucleoplasm	protein binding			ovary(4)|skin(1)	5						CTTTAAATTTGGCATTTCTTG	0.323			NA											49	16					0	0	0.000147903	0	0
ODZ1	10178	broad.mit.edu	37	X	123554306	123554306	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chrX:123554306G>C	uc004euj.2	-	24	4880	c.4816C>G	c.(4816-4818)CAA>GAA	p.Q1606E	ODZ1_uc011muj.1_Missense_Mutation_p.Q1612E|ODZ1_uc010nqy.2_Missense_Mutation_p.Q1613E	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	1606	Extracellular (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						CAGTATACTTGTCCGCCAGGC	0.522			NA											21	3					0	0	0.000175454	0	0
ODZ1	10178	broad.mit.edu	37	X	123838919	123838919	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chrX:123838919G>C	uc004euj.2	-	5	1023	c.959C>G	c.(958-960)GCA>GGA	p.A320G	ODZ1_uc011muj.1_Missense_Mutation_p.A320G|ODZ1_uc010nqy.2_Missense_Mutation_p.A320G	NM_014253	NP_055068	Q9UKZ4	TEN1_HUMAN	odz, odd Oz/ten-m homolog 1 isoform 3	320	Cytoplasmic (Potential).				immune response|negative regulation of cell proliferation|nervous system development|signal transduction	extracellular region	heparin binding			ovary(11)|breast(4)|large_intestine(2)|skin(2)|pancreas(2)|upper_aerodigestive_tract(1)|lung(1)	23						GGCGCTCAATGCTGTGCACTT	0.483			NA											99	21					0	0	0.000147903	0	0
BCORL1	63035	broad.mit.edu	37	X	129184716	129184716	+	Missense_Mutation	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chrX:129184716G>C	uc004evb.1	+	11	4757	c.4643G>C	c.(4642-4644)CGG>CCG	p.R1548P	BCORL1_uc004evc.1_Missense_Mutation_p.R384P	NM_021946	NP_068765	Q5H9F3	BCORL_HUMAN	BCL6 co-repressor-like 1	1548	ANK 3.				chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus				ovary(4)|breast(2)|lung(1)	7						CTTCAGGGCCGGGCAGAGGGT	0.502			NA											4	132					0	0	1.23904e-05	0	0
CCDC160	347475	broad.mit.edu	37	X	133378844	133378844	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chrX:133378844G>A	uc011mvj.1	+	2	335	c.14G>A	c.(13-15)AGA>AAA	p.R5K		NM_001101357	NP_001094827	A6NGH7	CC160_HUMAN	coiled-coil domain containing 160	5										skin(1)	1						GATGCTAGAAGAAAACACTGG	0.368			NA											19	1					0	0	0.000132079	0	0
GABRQ	55879	broad.mit.edu	37	X	151818273	151818273	+	Missense_Mutation	SNP	G	G	A			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chrX:151818273G>A	uc004ffp.1	+	6	699	c.679G>A	c.(679-681)GAG>AAG	p.E227K		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) receptor, theta	227	Extracellular (Potential).					cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					CATGACTGAGGAGCTGCATAT	0.483			NA											64	13					0	0	0.000147903	0	0
SPRY3	10251	broad.mit.edu	37	X	155003545	155003545	+	Silent	SNP	G	G	C			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chrX:155003545G>C	uc004fnq.1	+	2	466	c.12G>C	c.(10-12)GCG>GCC	p.A4A	SPRY3_uc010nvl.1_Silent_p.A4A	NM_005840	NP_005831	O43610	SPY3_HUMAN	sprouty homolog 3	4					multicellular organismal development|regulation of signal transduction	cytoplasm|membrane					0	all_cancers(53;1.86e-17)|all_epithelial(53;2.71e-11)|all_lung(58;1.84e-07)|Lung NSC(58;5.62e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)|Renal(33;0.214)					TGGATGCTGCGGTGACAGATG	0.458			NA											4	225					0	0	0.00024832	0	0
F3	2152	broad.mit.edu	37	1	95005860	95005861	+	Frame_Shift_Del	DEL	CA	CA	-			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	CA	CA	-	-	CA	CA	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr1:95005860_95005861delCA	uc001dqr.2	-	2	343_344	c.164_165delTG	c.(163-165)TTGfs	p.L55fs	F3_uc001dqp.2_RNA|F3_uc001dqq.2_RNA|F3_uc001dqs.2_Frame_Shift_Del_p.L55fs|F3_uc001dqt.2_RNA	NM_001993	NP_001984	P13726	TF_HUMAN	coagulation factor III precursor	55	Extracellular (Potential).				activation of caspase activity|activation of plasma proteins involved in acute inflammatory response|anti-apoptosis|blood coagulation, extrinsic pathway|positive regulation of angiogenesis|positive regulation of endothelial cell proliferation|positive regulation of platelet-derived growth factor receptor signaling pathway|positive regulation of protein kinase B signaling cascade	extracellular matrix|extracellular space|integral to membrane	cell surface binding|phospholipid binding|protease binding			central_nervous_system(1)	1		all_lung(203;0.00106)|Lung NSC(277;0.00475)		all cancers(265;0.0232)|Epithelial(280;0.121)	Coagulation factor VIIa(DB00036)	GTTCCCACTCCAAAATTGTCTT	0.356	Melanoma(40;358 1339 15970 39161)		NA											41	272	---	---	---	---	NA	NA	NA	NA	NA
ARID2	196528	broad.mit.edu	37	12	46205235	46205235	+	Frame_Shift_Del	DEL	G	G	-			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr12:46205235delG	uc001ros.1	+	4	319	c.319delG	c.(319-321)GGGfs	p.G107fs	ARID2_uc001ror.2_Frame_Shift_Del_p.G107fs	NM_152641	NP_689854	Q68CP9	ARID2_HUMAN	AT rich interactive domain 2 (ARID, RFX-like)	107					chromatin modification|regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|protein binding|zinc ion binding			ovary(6)|skin(3)|upper_aerodigestive_tract(1)	10	Lung SC(27;0.192)|Renal(347;0.236)	Lung NSC(34;0.106)|all_lung(34;0.22)	OV - Ovarian serous cystadenocarcinoma(5;0.00691)	GBM - Glioblastoma multiforme(48;0.0153)		TCATCATTTTGGGGAGGATGA	0.393			NA											35	46	---	---	---	---	NA	NA	NA	NA	NA
SNAP23	8773	broad.mit.edu	37	15	42820530	42820530	+	Frame_Shift_Del	DEL	A	A	-			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr15:42820530delA	uc001zpz.1	+	6	428	c.337delA	c.(337-339)AATfs	p.N113fs	SNAP23_uc001zqa.1_Intron	NM_003825	NP_003816	O00161	SNP23_HUMAN	synaptosomal-associated protein 23 isoform	113					cellular membrane fusion|post-Golgi vesicle-mediated transport|protein transport|vesicle targeting	azurophil granule|cell junction|Golgi apparatus|nucleus|plasma membrane enriched fraction|specific granule|synapse|synaptosome	protein binding				0		all_cancers(109;7.14e-17)|all_epithelial(112;3.78e-15)|Lung NSC(122;1.18e-08)|all_lung(180;4.2e-08)|Melanoma(134;0.0179)|Colorectal(260;0.152)		GBM - Glioblastoma multiforme(94;2.62e-06)		CTCACCTTGCAATGTAGTATC	0.463			NA											43	69	---	---	---	---	NA	NA	NA	NA	NA
SQRDL	58472	broad.mit.edu	37	15	45965969	45965969	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr15:45965969delC	uc001zvt.2	+	6	813	c.624delC	c.(622-624)ATCfs	p.I208fs	SQRDL_uc001zvu.2_Frame_Shift_Del_p.I208fs|SQRDL_uc001zvv.2_Frame_Shift_Del_p.I208fs	NM_021199	NP_067022	Q9Y6N5	SQRD_HUMAN	sulfide dehydrogenase like precursor	208							oxidoreductase activity			ovary(1)	1		Lung NSC(122;0.000117)|all_lung(180;0.000737)|Melanoma(134;0.0417)		all cancers(107;5.89e-18)|GBM - Glioblastoma multiforme(94;1.21e-06)|COAD - Colon adenocarcinoma(120;0.17)|Colorectal(133;0.188)		CTCAGAAGATCATGTACTTAT	0.478			NA											30	51	---	---	---	---	NA	NA	NA	NA	NA
TP53	7157	broad.mit.edu	37	17	7578514	7578514	+	Frame_Shift_Del	DEL	T	T	-			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr17:7578514delT	uc002gim.2	-	5	610	c.416delA	c.(415-417)AAGfs	p.K139fs	TP53_uc002gig.1_Frame_Shift_Del_p.K139fs|TP53_uc002gih.2_Frame_Shift_Del_p.K139fs|TP53_uc010cne.1_5'Flank|TP53_uc010cnf.1_Frame_Shift_Del_p.K7fs|TP53_uc010cng.1_Frame_Shift_Del_p.K7fs|TP53_uc002gii.1_Frame_Shift_Del_p.K7fs|TP53_uc010cnh.1_Frame_Shift_Del_p.K139fs|TP53_uc010cni.1_Frame_Shift_Del_p.K139fs|TP53_uc002gij.2_Frame_Shift_Del_p.K139fs|TP53_uc010cnj.1_RNA|TP53_uc002gin.2_Frame_Shift_Del_p.K46fs|TP53_uc002gio.2_Frame_Shift_Del_p.K7fs|TP53_uc010vug.1_Frame_Shift_Del_p.K100fs	NM_001126112	NP_001119584	P04637	P53_HUMAN	tumor protein p53 isoform a	139	Required for interaction with FBXO42.||Interaction with HIPK1 (By similarity).|Interaction with AXIN1 (By similarity).		K -> N (in sporadic cancers; somatic mutation).|K -> T (in sporadic cancers; somatic mutation).|K -> Q (in sporadic cancers; somatic mutation).|K -> R (in sporadic cancers; somatic mutation).|K -> E (in sporadic cancers; somatic mutation).		activation of caspase activity by cytochrome c|base-excision repair|blood coagulation|cell cycle arrest|cell differentiation|cell proliferation|cellular protein localization|cellular response to drug|cellular response to glucose starvation|cellular response to hypoxia|cellular response to ionizing radiation|cellular response to UV|determination of adult lifespan|DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator|ER overload response|interspecies interaction between organisms|negative regulation of apoptosis|negative regulation of cell growth|negative regulation of cell proliferation|negative regulation of helicase activity|negative regulation of transcription from RNA polymerase II promoter|negative regulation of transcription from RNA polymerase II promoter|nucleotide-excision repair|oxidative stress-induced premature senescence|positive regulation of histone deacetylation|positive regulation of neuron apoptosis|positive regulation of peptidyl-tyrosine phosphorylation|positive regulation of reactive oxygen species metabolic process|positive regulation of thymocyte apoptosis|positive regulation of transcription from RNA polymerase II promoter|positive regulation of transcription from RNA polymerase II promoter|protein localization|protein tetramerization|Ras protein signal transduction|regulation of mitochondrial membrane permeability|replicative senescence|response to antibiotic|response to gamma radiation|response to X-ray	cytoplasm|cytosol|endoplasmic reticulum|insoluble fraction|mitochondrion|nuclear chromatin|nuclear matrix|nucleolus|nucleus|PML body|protein complex|replication fork	ATP binding|chaperone binding|chromatin binding|copper ion binding|damaged DNA binding|DNA strand annealing activity|histone acetyltransferase binding|p53 binding|protease binding|protein binding|protein heterodimerization activity|protein kinase binding|protein N-terminus binding|protein phosphatase 2A binding|RNA polymerase II transcription factor binding|sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding|transcription regulatory region DNA binding|transcription repressor activity|ubiquitin protein ligase binding|zinc ion binding	p.K139N(8)|p.K139K(7)|p.0?(7)|p.K139fs*31(4)|p.K139fs*9(3)|p.K139Q(2)|p.K139R(2)|p.K139E(2)|p.N131fs*27(2)|p.K139*(2)|p.K139T(1)|p.L137_W146del10(1)|p.K139fs*4(1)|p.F134_T140>S(1)|p.A138_V143delAKTCPV(1)|p.K139fs*11(1)|p.K139fs*10(1)|p.A138_P142delAKTCP(1)|p.Q136_K139delQLAK(1)|p.K139_C141>N(1)|p.C135_T140delCQLAKT(1)|p.K139fs*29(1)		large_intestine(4656)|breast(2429)|upper_aerodigestive_tract(2212)|lung(2028)|ovary(1592)|oesophagus(1462)|haematopoietic_and_lymphoid_tissue(1228)|stomach(1136)|urinary_tract(1114)|central_nervous_system(1085)|liver(805)|skin(694)|pancreas(375)|biliary_tract(247)|soft_tissue(209)|prostate(194)|endometrium(150)|bone(102)|vulva(79)|kidney(79)|cervix(68)|thyroid(54)|salivary_gland(43)|adrenal_gland(37)|peritoneum(33)|eye(24)|thymus(21)|genital_tract(16)|autonomic_ganglia(16)|small_intestine(14)|testis(11)|penis(10)|vagina(6)|meninges(5)|pituitary(4)|pleura(3)|gastrointestinal_tract_(site_indeterminate)(1)|NS(1)|Fallopian tube(1)|placenta(1)	22245		all_cancers(10;1.01e-06)|Myeloproliferative disorder(207;0.0122)|Prostate(122;0.081)		GBM - Glioblastoma multiforme(2;1.59e-06)|READ - Rectum adenocarcinoma(115;0.174)		AGGGCAGGTCTTGGCCAGTTG	0.562	Pancreas(47;798 1329 9957 10801)		111	Mis|N|F		breast|colorectal|lung|sarcoma|adrenocortical|glioma|multiple other tumour types	breast|sarcoma|adrenocortical carcinoma|glioma|multiple other tumour types		Other_conserved_DNA_damage_response_genes	Hereditary_Adrenocortical_Cancer|Endometrial_Cancer_Familial_Clustering_of|Hereditary_Breast-Ovarian_Cancer_non-BRCA1/2|Li-Fraumensyndrome|Osteosarcoma_Familial_Clustering_of	HNSCC(1;<9.43e-08)|TCGA GBM(1;<1E-08)|TSP Lung(2;<1E-08)|TCGA Ovarian(1;<1.89e-07)|Multiple Myeloma(5;0.019)			30	12	---	---	---	---	NA	NA	NA	NA	NA
LRP1B	53353	broad.mit.edu	37	2	140992354	140992354	+	Splice_Site	DEL	C	C	-			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr2:140992354delC	uc002tvj.1	-	90	14631	c.13659_splice	c.e90+1	p.G4553_splice		NM_018557	NP_061027	Q9NZR2	LRP1B_HUMAN	low density lipoprotein-related protein 1B						protein transport|receptor-mediated endocytosis	integral to membrane	calcium ion binding			lung(17)|skin(12)|ovary(12)|pancreas(3)|upper_aerodigestive_tract(2)|central_nervous_system(2)|liver(1)|kidney(1)	50		all_cancers(3;1.1e-60)|all_epithelial(3;1.94e-59)|all_lung(3;1.09e-24)|Lung NSC(3;5.65e-24)|Esophageal squamous(3;5.41e-13)|Renal(3;0.000147)|Breast(3;0.000527)|Hepatocellular(3;0.011)|all_neural(3;0.014)|Colorectal(150;0.101)		UCEC - Uterine corpus endometrioid carcinoma (2;0.00139)|Epithelial(1;1.25e-24)|all cancers(1;8.86e-24)|OV - Ovarian serous cystadenocarcinoma(1;2.45e-12)|LUSC - Lung squamous cell carcinoma(1;2.97e-10)|Lung(1;6.05e-09)|BRCA - Breast invasive adenocarcinoma(221;0.0103)		tcttctctcaccccagcagtt	0.095	Colon(99;50 2074 2507 20106)		NA								TSP Lung(27;0.18)			29	57	---	---	---	---	NA	NA	NA	NA	NA
SSPO	23145	broad.mit.edu	37	7	149474054	149474054	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr7:149474054delC	uc010lpk.2	+	3	264	c.264delC	c.(262-264)AACfs	p.N88fs	SSPO_uc010lpl.1_Intron	NM_198455	NP_940857	A2VEC9	SSPO_HUMAN	SCO-spondin precursor	88	EMI.				cell adhesion	extracellular space	peptidase inhibitor activity				0	Melanoma(164;0.165)|Ovarian(565;0.177)		OV - Ovarian serous cystadenocarcinoma(82;0.00625)			CCAAGTGGAACCGGACAGTGA	0.642			NA											20	66	---	---	---	---	NA	NA	NA	NA	NA
FAM75A6	389730	broad.mit.edu	37	9	43625677	43625677	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chr9:43625677delC	uc011lrb.1	-	4	3039	c.3010delG	c.(3010-3012)GAGfs	p.E1004fs		NM_001145196	NP_001138668	Q5VVP1	F75A6_HUMAN	hypothetical protein LOC389730	1004						integral to membrane					0						CTAACAACCTCCTCCATAAGA	0.512			NA											4	6	---	---	---	---	NA	NA	NA	NA	NA
ARHGAP6	395	broad.mit.edu	37	X	11157265	11157265	+	Frame_Shift_Del	DEL	C	C	-			TCGA-05-4396-01A-21D-1855-08	TCGA-05-4396-10A-01D-1855-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	0176cf1d-0760-4769-a493-277f4bb7585e	1f8820d1-4a97-41b7-a4d8-be832c9e0575	g.chrX:11157265delC	uc004cup.1	-	13	3516	c.2643delG	c.(2641-2643)CCGfs	p.P881fs	ARHGAP6_uc004cuo.1_RNA|ARHGAP6_uc004cum.1_Frame_Shift_Del_p.P678fs|ARHGAP6_uc004cun.1_Frame_Shift_Del_p.P701fs	NM_013427	NP_038286	O43182	RHG06_HUMAN	Rho GTPase activating protein 6 isoform 1	881					actin filament polymerization|activation of phospholipase C activity|negative regulation of focal adhesion assembly|negative regulation of stress fiber assembly|Rho protein signal transduction	actin filament|cytosol	phospholipase activator activity|phospholipase binding|Rho GTPase activator activity|SH3 domain binding|SH3/SH2 adaptor activity			urinary_tract(1)|lung(1)	2						GGTATGGAGGCGGGGGCCGCT	0.706			NA											2	4	---	---	---	---	NA	NA	NA	NA	NA
