Hugo_Symbol	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_position	End_position	Strand	Variant_Classification	Variant_Type	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	dbSNP_RS	dbSNP_Val_Status	Tumor_Sample_Barcode	Matched_Norm_Sample_Barcode	Match_Norm_Seq_Allele1	Match_Norm_Seq_Allele2	Tumor_Validation_Allele1	Tumor_Validation_Allele2	Match_Norm_Validation_Allele1	Match_Norm_Validation_Allele2	Verification_Status	Validation_Status	Mutation_Status	Sequencing_Phase	Sequence_Source	Validation_Method	Score	BAM_file	Sequencer	Tumor_Sample_UUID	Matched_Norm_Sample_UUID	Genome_Change	Annotation_Transcript	Transcript_Strand	Transcript_Exon	Transcript_Position	cDNA_Change	Codon_Change	Protein_Change	Other_Transcripts	Refseq_mRNA_Id	Refseq_prot_Id	SwissProt_acc_Id	SwissProt_entry_Id	Description	UniProt_AApos	UniProt_Region	UniProt_Site	UniProt_Natural_Variations	UniProt_Experimental_Info	GO_Biological_Process	GO_Cellular_Component	GO_Molecular_Function	COSMIC_overlapping_mutations	COSMIC_fusion_genes	COSMIC_tissue_types_affected	COSMIC_total_alterations_in_gene	Tumorscape_Amplification_Peaks	Tumorscape_Deletion_Peaks	TCGAscape_Amplification_Peaks	TCGAscape_Deletion_Peaks	DrugBank	ref_context	gc_content	ACHILLES_Top_Genes	CCLE_ONCOMAP_overlapping_mutations	CCLE_ONCOMAP_total_mutations_in_gene	CGC_Mutation_Type	CGC_Translocation_Partner	CGC_Tumor_Types_Somatic	CGC_Tumor_Types_Germline	CGC_Other_Diseases	DNARepairGenes_Role	FamilialCancerDatabase_Syndromes	MUTSIG_Published_Results	OREGANNO_ID	OREGANNO_Values	t_alt_count	t_ref_count	validation_status	validation_method	validation_tumor_sample	validation_alt_allele	pox	qox	pox_cutoff	isArtifactMode	oxoGCut
GABRD	2563	broad.mit.edu	37	1	1961436	1961436	+	Silent	SNP	C	C	T	rs75511732		TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr1:1961436C>T	uc001aip.2	+	9	1169	c.1074C>T	c.(1072-1074)AAC>AAT	p.N358N		NM_000815	NP_000806	O14764	GBRD_HUMAN	gamma-aminobutyric acid (GABA) A receptor, delta	358	Cytoplasmic (Probable).					cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity			ovary(1)|central_nervous_system(1)|skin(1)	3	all_cancers(77;0.000708)|all_epithelial(69;0.000943)|all_lung(157;0.00963)|Lung NSC(156;0.0232)|Ovarian(185;0.0634)	all_epithelial(116;2.7e-19)|all_lung(118;1.22e-08)|Lung NSC(185;1.24e-06)|Renal(390;0.00183)|Breast(487;0.00354)|Hepatocellular(190;0.00826)|Myeloproliferative disorder(586;0.0122)|Ovarian(437;0.0308)|Medulloblastoma(700;0.123)|Lung SC(97;0.128)		Epithelial(90;2.19e-38)|OV - Ovarian serous cystadenocarcinoma(86;3.17e-24)|GBM - Glioblastoma multiforme(42;9.56e-08)|Colorectal(212;4.12e-05)|COAD - Colon adenocarcinoma(227;0.000194)|Kidney(185;0.00231)|BRCA - Breast invasive adenocarcinoma(365;0.00441)|STAD - Stomach adenocarcinoma(132;0.00644)|KIRC - Kidney renal clear cell carcinoma(229;0.0344)|Lung(427;0.2)		ACGTGAGGAACGCCATTGTCC	0.687			NA											12	73					0	0	0.003163	0	0
CCDC28B	79140	broad.mit.edu	37	1	32667694	32667694	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr1:32667694T>C	uc001bul.1	+	2	290	c.158T>C	c.(157-159)TTC>TCC	p.F53S	CCDC28B_uc001buk.2_Missense_Mutation_p.F53S	NM_024296	NP_077272	Q9BUN5	CC28B_HUMAN	coiled-coil domain containing 28B	53											0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.0837)|Ovarian(437;0.101)|Breast(348;0.174)				CGGGCCAAGTTCAAGAGGTGG	0.612			NA											10	47					0	0	0.006214	0	0
RSPO1	284654	broad.mit.edu	37	1	38082223	38082223	+	Silent	SNP	G	G	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr1:38082223G>A	uc001cbl.1	-	5	1007	c.219C>T	c.(217-219)GGC>GGT	p.G73G	RSPO1_uc001cbm.1_Silent_p.G73G|RSPO1_uc009vvf.1_Silent_p.G46G|RSPO1_uc009vvg.1_Silent_p.G73G	NM_001038633	NP_001033722	Q2MKA7	RSPO1_HUMAN	R-spondin1 precursor	73	FU 1.				positive regulation of canonical Wnt receptor signaling pathway|regulation of receptor internalization		heparin binding				0		Myeloproliferative disorder(586;0.0255)|all_neural(195;0.164)				GCAAGCAGACGCCCACCTGGC	0.622	GBM(122;680 2230 27822 42821)		NA											16	151					0	0	0.006122	0	0
LRRC40	55631	broad.mit.edu	37	1	70625094	70625095	+	Missense_Mutation	DNP	GC	GC	AT			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr1:70625094_70625095GC>AT	uc001der.1	-	10	1190_1191	c.1138_1139GC>AT	c.(1138-1140)GCT>ATT	p.A380I		NM_017768	NP_060238	Q9H9A6	LRC40_HUMAN	leucine rich repeat containing 40	380										ovary(1)	1						AGTCTCAGTAGCAGACTCACTT	0.302			NA											5	38					0	0	0.004672	0	0
DNTTIP2	30836	broad.mit.edu	37	1	94342445	94342445	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr1:94342445G>A	uc001dqf.2	-	2	1084	c.1046C>T	c.(1045-1047)TCA>TTA	p.S349L	DNTTIP2_uc010otm.1_RNA|DNTTIP2_uc009wdo.1_Missense_Mutation_p.S144L	NM_014597	NP_055412	Q5QJE6	TDIF2_HUMAN	deoxynucleotidyltransferase, terminal,	349					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus					0		all_lung(203;0.0111)|Lung NSC(277;0.0347)		all cancers(265;0.00679)|GBM - Glioblastoma multiforme(16;0.0278)|Epithelial(280;0.128)		AGAGTGCACTGATACAGCATT	0.393			NA											14	86					0	0	0.00245	0	0
LOC728989	728989	broad.mit.edu	37	1	146493351	146493351	+	Missense_Mutation	SNP	A	A	G	rs141632041	by1000genomes	TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr1:146493351A>G	uc001epd.2	-	5	636	c.562T>C	c.(562-564)TGG>CGG	p.W188R		NR_024442				SubName: Full=cDNA FLJ59595, highly similar to Homo sapiens phosphodiesterase 4D interacting protein, transcript variant 1, mRNA;												0						TGAAGGAGCCACTCCTGTTTG	0.488			NA											3	42					0	0	0.000602	0	0
FLG2	388698	broad.mit.edu	37	1	152323784	152323784	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr1:152323784A>T	uc001ezw.3	-	3	6551	c.6478T>A	c.(6478-6480)TCT>ACT	p.S2160T	uc001ezv.2_Intron	NM_001014342	NP_001014364	Q5D862	FILA2_HUMAN	filaggrin family member 2	2160	Filaggrin 10.						calcium ion binding|structural molecule activity			ovary(10)|skin(5)|upper_aerodigestive_tract(1)|breast(1)	17	Hepatocellular(266;0.0877)|Melanoma(130;0.116)|all_hematologic(923;0.127)		LUSC - Lung squamous cell carcinoma(543;0.206)			CCATGACCAGACTGGCCATGT	0.512			NA											127	498					0	0	0.01441	0	0
LCE3C	353144	broad.mit.edu	37	1	152573217	152573217	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr1:152573217C>A	uc001fac.2	+	1	80	c.10C>A	c.(10-12)CAG>AAG	p.Q4K		NM_178434	NP_848521	Q5T5A8	LCE3C_HUMAN	late cornified envelope 3C	4					keratinization						0	Hepatocellular(266;0.0877)|all_hematologic(923;0.127)|Melanoma(130;0.242)		LUSC - Lung squamous cell carcinoma(543;0.206)	UCEC - Uterine corpus endometrioid carcinoma (5;0.153)|KIRC - Kidney renal clear cell carcinoma(4;0.0313)|Kidney(5;0.0367)		GATGTCCTGCCAGCAAAACCA	0.507			NA											55	641					1.95512e-22	2.62884e-22	0.01441	1	0
CRTC2	200186	broad.mit.edu	37	1	153927404	153927404	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr1:153927404C>T	uc010ped.1	-	3	387	c.317G>A	c.(316-318)CGG>CAG	p.R106Q	CRTC2_uc001fde.3_5'Flank|CRTC2_uc001fdf.3_5'Flank	NM_181715	NP_859066	Q53ET0	CRTC2_HUMAN	CREB regulated transcription coactivator 2	106					interspecies interaction between organisms|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	protein binding			ovary(2)	2	all_lung(78;3.05e-32)|Lung NSC(65;3.74e-30)|Hepatocellular(266;0.0877)|Melanoma(130;0.199)		LUSC - Lung squamous cell carcinoma(543;0.151)			TCGCTGCACCCGTTCCACCAG	0.567			NA											8	71					0	0	0.008291	0	0
FCRL3	115352	broad.mit.edu	37	1	157666998	157666998	+	Nonsense_Mutation	SNP	C	C	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr1:157666998C>T	uc001frb.2	-	6	1068	c.776G>A	c.(775-777)TGG>TAG	p.W259*	FCRL3_uc001fqx.3_RNA|FCRL3_uc001fqy.3_RNA|FCRL3_uc001fqz.3_Nonsense_Mutation_p.W259*|FCRL3_uc009wsn.2_Intron|FCRL3_uc009wso.2_RNA|FCRL3_uc001fra.2_5'UTR|FCRL3_uc001frc.1_Nonsense_Mutation_p.W259*	NM_052939	NP_443171	Q96P31	FCRL3_HUMAN	Fc receptor-like 3 precursor	259	Ig-like C2-type 3.|Extracellular (Potential).					integral to membrane|plasma membrane	receptor activity			ovary(3)|breast(1)	4	all_hematologic(112;0.0378)					CACCTCACACCAGTAAGACCC	0.537			NA											21	130					0	0	0.014323	0	0
FMO4	2329	broad.mit.edu	37	1	171293296	171293296	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr1:171293296C>T	uc001gho.2	+	5	558	c.341C>T	c.(340-342)ACG>ATG	p.T114M		NM_002022	NP_002013	P31512	FMO4_HUMAN	flavin containing monooxygenase 4	114					xenobiotic metabolic process	integral to membrane|intrinsic to endoplasmic reticulum membrane|microsome	flavin adenine dinucleotide binding|flavin-containing monooxygenase activity|NADP binding			kidney(2)|skin(1)	3	all_cancers(6;3.9e-08)|all_hematologic(923;0.088)|Acute lymphoblastic leukemia(37;0.181)					TGCAGCATAACGAAGCGTCCA	0.463	Pancreas(24;816 862 7754 7993 32832)		NA											121	490					0	0	0.01441	0	0
CFHR5	81494	broad.mit.edu	37	1	196977743	196977743	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr1:196977743C>A	uc001gts.3	+	10	1768	c.1640C>A	c.(1639-1641)GCG>GAG	p.A547E		NM_030787	NP_110414	Q9BXR6	FHR5_HUMAN	complement factor H-related 5 precursor	547	Sushi 9.				complement activation, alternative pathway	extracellular region				breast(1)|skin(1)	2						CCACATAAAGCGATGATATCA	0.343			NA											11	142					1.61879e-10	2.00087e-10	0.013537	1	0
FMOD	2331	broad.mit.edu	37	1	203316507	203316507	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr1:203316507G>T	uc001gzr.2	-	2	1028	c.892C>A	c.(892-894)CTA>ATA	p.L298I	FMOD_uc010pqi.1_RNA	NM_002023	NP_002014	Q06828	FMOD_HUMAN	fibromodulin precursor	298	LRR 9.				transforming growth factor beta receptor complex assembly	extracellular space|proteinaceous extracellular matrix				ovary(2)|breast(1)	3			BRCA - Breast invasive adenocarcinoma(75;0.171)			GAGAGGTCTAGCTCAAGGAGG	0.567			NA											67	173					1.26778e-28	1.728e-28	0.01441	1	0
KCNK2	3776	broad.mit.edu	37	1	215259842	215259842	+	Nonsense_Mutation	SNP	A	A	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr1:215259842A>T	uc001hkq.2	+	2	347	c.178A>T	c.(178-180)AAG>TAG	p.K60*	KCNK2_uc001hko.2_Nonsense_Mutation_p.K56*|KCNK2_uc009xdm.2_RNA|KCNK2_uc001hkp.2_RNA|KCNK2_uc010pua.1_RNA|KCNK2_uc001hkr.3_Nonsense_Mutation_p.K45*	NM_001017425	NP_001017425	O95069	KCNK2_HUMAN	potassium channel, subfamily K, member 2 isoform	60	Cytoplasmic (Potential).						outward rectifier potassium channel activity				0				OV - Ovarian serous cystadenocarcinoma(81;0.0399)|all cancers(67;0.0556)|GBM - Glioblastoma multiforme(131;0.068)	Dofetilide(DB00204)	TATGAAATGGAAGACGGTCTC	0.512			NA											52	54					0	0	0.01441	0	0
FMN2	56776	broad.mit.edu	37	1	240371640	240371640	+	Silent	SNP	G	G	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr1:240371640G>A	uc010pyd.1	+	5	3753	c.3528G>A	c.(3526-3528)CCG>CCA	p.P1176P	FMN2_uc010pye.1_Silent_p.P1180P	NM_020066	NP_064450	Q9NZ56	FMN2_HUMAN	formin 2	1176	Pro-rich.|FH1.				actin cytoskeleton organization|establishment of meiotic spindle localization|intracellular signal transduction|meiotic chromosome movement towards spindle pole|meiotic metaphase I|multicellular organismal development|oogenesis|polar body extrusion after meiotic divisions		actin binding			ovary(4)|pancreas(3)|skin(3)|large_intestine(1)|central_nervous_system(1)	12	Ovarian(103;0.127)	all_cancers(173;0.013)	OV - Ovarian serous cystadenocarcinoma(106;0.0106)			TACCCCCTCCGCCCCCTCTAC	0.687			NA											7	8					0	0	0.00308	0	0
SFMBT2	57713	broad.mit.edu	37	10	7262456	7262456	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr10:7262456G>T	uc009xio.1	-	11	1338	c.1247C>A	c.(1246-1248)GCT>GAT	p.A416D	SFMBT2_uc001ijn.1_Missense_Mutation_p.A416D|SFMBT2_uc010qay.1_Intron	NM_001029880	NP_001025051	Q5VUG0	SMBT2_HUMAN	Scm-like with four mbt domains 2	416	MBT 4.				regulation of transcription, DNA-dependent	nucleus				ovary(4)|upper_aerodigestive_tract(2)|large_intestine(1)|central_nervous_system(1)	8						GGGGTTCACAGCTTCAAGTTT	0.532			NA											102	74					8.32725e-61	1.15883e-60	0.01441	1	0
GPR158	57512	broad.mit.edu	37	10	25887829	25887829	+	Missense_Mutation	SNP	A	A	G			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr10:25887829A>G	uc001isj.2	+	11	3334	c.3274A>G	c.(3274-3276)ACT>GCT	p.T1092A	GPR158_uc001isk.2_Missense_Mutation_p.T467A	NM_020752	NP_065803	Q5T848	GP158_HUMAN	G protein-coupled receptor 158 precursor	1092	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity			ovary(4)|large_intestine(2)|pancreas(1)|skin(1)	8						GATTTCCAAGACTCCAGTTCT	0.517			NA											88	54					0	0	0.01441	0	0
C10orf58	84293	broad.mit.edu	37	10	82180281	82180281	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr10:82180281G>A	uc001kcc.3	+	2	218	c.58G>A	c.(58-60)GGA>AGA	p.G20R	C10orf58_uc001kcd.3_Missense_Mutation_p.G9R|C10orf58_uc001kce.3_Missense_Mutation_p.G20R|C10orf58_uc001kcf.3_Missense_Mutation_p.G20R	NM_032333	NP_115709	Q9BRX8	CJ058_HUMAN	hypothetical protein LOC84293 precursor	20						extracellular region					0			Colorectal(32;0.229)			CATTGGTGCAGGAGCCCTGGG	0.547			NA											5	129					0	0	0.000602	0	0
OBFC1	79991	broad.mit.edu	37	10	105657388	105657388	+	Missense_Mutation	SNP	A	A	C			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr10:105657388A>C	uc001kxl.2	-	6	746	c.671T>G	c.(670-672)TTT>TGT	p.F224C	OBFC1_uc001kxm.2_Missense_Mutation_p.F224C|OBFC1_uc001kxn.2_RNA	NM_024928	NP_079204	Q9H668	STN1_HUMAN	oligonucleotide/oligosaccharide-binding fold	224					positive regulation of DNA replication|telomere maintenance via telomere lengthening		protein binding|single-stranded telomeric DNA binding			ovary(1)	1		Colorectal(252;0.178)		Epithelial(162;3.39e-10)|all cancers(201;1.32e-08)|BRCA - Breast invasive adenocarcinoma(275;0.0151)		CTGCTGGTAAAAGCTCTGCAC	0.547			NA											73	36					0	0	0.01441	0	0
OR52M1	119772	broad.mit.edu	37	11	4566720	4566720	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr11:4566720G>T	uc010qyf.1	+	1	300	c.300G>T	c.(298-300)TTG>TTT	p.L100F		NM_001004137	NP_001004137	Q8NGK5	O52M1_HUMAN	olfactory receptor, family 52, subfamily M,	100	Extracellular (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity				0		Medulloblastoma(188;0.0075)|Breast(177;0.0461)|all_neural(188;0.0577)		Epithelial(150;8.45e-12)|BRCA - Breast invasive adenocarcinoma(625;0.0285)|LUSC - Lung squamous cell carcinoma(625;0.19)		ACGCCTGCTTGGGCCAAATGT	0.517			NA											19	142					6.33239e-15	8.29043e-15	0.010504	1	0
ANO5	203859	broad.mit.edu	37	11	22281108	22281108	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr11:22281108G>A	uc001mqi.2	+	15	1768	c.1451G>A	c.(1450-1452)CGC>CAC	p.R484H	ANO5_uc001mqj.2_Missense_Mutation_p.R483H	NM_213599	NP_998764	Q75V66	ANO5_HUMAN	anoctamin 5 isoform a	484	Extracellular (Potential).					chloride channel complex|endoplasmic reticulum membrane	chloride channel activity			central_nervous_system(3)|ovary(1)	4						ATTGTGTACCGCCTGTCAGTC	0.413			NA											18	108					0	0	0.012319	0	0
TRAF6	7189	broad.mit.edu	37	11	36520069	36520069	+	Silent	SNP	A	A	G			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr11:36520069A>G	uc001mwr.1	-	4	758	c.418T>C	c.(418-420)TTG>CTG	p.L140L	TRAF6_uc001mws.1_Silent_p.L140L	NM_145803	NP_665802	Q9Y4K3	TRAF6_HUMAN	TNF receptor-associated factor 6	140	Interaction with TAX1BP1.				activation of MAPK activity|activation of NF-kappaB-inducing kinase activity|anti-apoptosis|apoptosis|induction of apoptosis by extracellular signals|innate immune response|JNK cascade|membrane protein intracellular domain proteolysis|MyD88-dependent toll-like receptor signaling pathway|MyD88-independent toll-like receptor signaling pathway|negative regulation of transcription from RNA polymerase II promoter|nerve growth factor receptor signaling pathway|ossification|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-2 production|positive regulation of JUN kinase activity|positive regulation of NF-kappaB transcription factor activity|positive regulation of osteoclast differentiation|positive regulation of T cell cytokine production|protein autoubiquitination|protein K63-linked ubiquitination|response to interleukin-1|stress-activated MAPK cascade|T cell receptor signaling pathway|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 3 signaling pathway|toll-like receptor 4 signaling pathway	CD40 receptor complex|cell cortex|cytosol|endosome membrane|internal side of plasma membrane|nuclear membrane	histone deacetylase binding|mitogen-activated protein kinase kinase kinase binding|protein kinase B binding|protein N-terminus binding|ubiquitin-protein ligase activity|zinc ion binding			ovary(1)	1	all_lung(20;0.211)	all_hematologic(20;0.107)				ATCTTGTGCAAACAACCTTCA	0.303			NA											40	130					0	0	0.01441	0	0
MAPK8IP1	9479	broad.mit.edu	37	11	45926281	45926281	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr11:45926281C>T	uc001nbr.2	+	9	1959	c.1789C>T	c.(1789-1791)CGC>TGC	p.R597C		NM_005456	NP_005447	Q9UQF2	JIP1_HUMAN	mitogen-activated protein kinase 8 interacting	597	PID.				vesicle-mediated transport	nucleus|perinuclear region of cytoplasm	kinesin binding|MAP-kinase scaffold activity|protein kinase inhibitor activity			ovary(2)|breast(1)|skin(1)	4				GBM - Glioblastoma multiforme(35;0.231)		TGCCACCACCCGCCGGCTCAC	0.612			NA											23	86					0	0	0.005443	0	0
OR4A47	403253	broad.mit.edu	37	11	48510483	48510483	+	Missense_Mutation	SNP	G	G	A	rs142333570	byFrequency	TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr11:48510483G>A	uc010rhx.1	+	1	139	c.139G>A	c.(139-141)GTA>ATA	p.V47I		NM_001005512	NP_001005512	Q6IF82	O4A47_HUMAN	olfactory receptor, family 4, subfamily A,	47	Helical; Name=1; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2						TGTAGTGACCGTAACTGTCAG	0.418			NA											22	18					0	0	0.005443	0	0
GLYATL1	92292	broad.mit.edu	37	11	58723260	58723260	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr11:58723260G>T	uc001nnf.2	+	8	1045	c.669G>T	c.(667-669)ATG>ATT	p.M223I	uc001nng.1_Intron|GLYATL1_uc001nnh.1_Missense_Mutation_p.M254I|GLYATL1_uc001nni.1_Missense_Mutation_p.M223I|GLYATL1_uc001nnj.1_Missense_Mutation_p.M223I			Q969I3	GLYL1_HUMAN	SubName: Full=Glycine acyltransferase family-C; SubName: Full=Glycine-N-acyltransferase-like 1, isoform CRA_a;	223						mitochondrion	glycine N-acyltransferase activity			ovary(1)	1					Glycine(DB00145)	GGGTAACCATGGACCCTTCTT	0.522			NA											13	39					1.61879e-10	2.00087e-10	0.013537	1	0
FAM111B	374393	broad.mit.edu	37	11	58892054	58892054	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr11:58892054C>G	uc001nnl.2	+	4	727	c.484C>G	c.(484-486)CAA>GAA	p.Q162E	FAM111B_uc001nnm.2_Missense_Mutation_p.Q132E|FAM111B_uc010rko.1_Missense_Mutation_p.Q132E	NM_198947	NP_945185	Q6SJ93	F111B_HUMAN	hypothetical protein LOC374393 isoform a	162							catalytic activity			ovary(2)	2						TACATTTGGTCAAAGAAAGAG	0.338			NA											4	51					0	0	0.009096	0	0
NPAS4	266743	broad.mit.edu	37	11	66189606	66189606	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr11:66189606G>T	uc001ohx.1	+	2	367	c.191G>T	c.(190-192)GGC>GTC	p.G64V	NPAS4_uc010rpc.1_5'UTR	NM_178864	NP_849195	Q8IUM7	NPAS4_HUMAN	neuronal PAS domain protein 4	64					transcription, DNA-dependent		DNA binding|signal transducer activity				0						CCTCTGGCGGGCCCCACGGGG	0.572			NA											11	65					1.61879e-10	2.00087e-10	0.013537	1	0
CCDC87	55231	broad.mit.edu	37	11	66359594	66359594	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr11:66359594G>A	uc001oiq.3	-	1	961	c.893C>T	c.(892-894)TCC>TTC	p.S298F	CCS_uc001oir.2_5'Flank	NM_018219	NP_060689	Q9NVE4	CCD87_HUMAN	coiled-coil domain containing 87	298										ovary(1)|skin(1)	2						AGGCGAGGGGGAAGCCCTGCT	0.617			NA											37	133					0	0	0.004878	0	0
NUMA1	4926	broad.mit.edu	37	11	71719881	71719881	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr11:71719881G>C	uc001orl.1	-	20	5241	c.5069C>G	c.(5068-5070)GCA>GGA	p.A1690G	NUMA1_uc001orj.2_5'UTR|NUMA1_uc009ysw.1_Missense_Mutation_p.A1239G|NUMA1_uc001ork.1_Missense_Mutation_p.A554G|NUMA1_uc001orm.1_Missense_Mutation_p.A1676G|NUMA1_uc001orn.2_Missense_Mutation_p.A1253G	NM_006185	NP_006176	Q14980	NUMA1_HUMAN	nuclear mitotic apparatus protein 1	1690	Potential.				G2/M transition of mitotic cell cycle|mitotic anaphase|nucleus organization	chromosome|cytosol|nucleoplasm|spindle microtubule|spindle pole	protein binding|structural molecule activity			ovary(3)|lung(2)|skin(2)|central_nervous_system(1)	8						CTGCTGGTCTGCATGGGCAAC	0.577			NA	T	RARA	APL								13	161					0	0	0.004007	0	0
DPAGT1	1798	broad.mit.edu	37	11	118971518	118971518	+	Silent	SNP	G	G	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr11:118971518G>A	uc001pvi.2	-	3	738	c.318C>T	c.(316-318)TGC>TGT	p.C106C	DPAGT1_uc001pvj.2_5'UTR|DPAGT1_uc009zaq.2_RNA|DPAGT1_uc001pvk.2_Intron|DPAGT1_uc010ryz.1_Silent_p.C106C|DPAGT1_uc001pvm.1_5'UTR|DPAGT1_uc010rza.1_5'UTR	NM_001382	NP_001373	Q9H3H5	GPT_HUMAN	UDP-N-acetylglucosamine-dolichyl-phosphate	106	Helical; (Potential).				dolichol biosynthetic process|dolichol-linked oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine|protein oligomerization	integral to endoplasmic reticulum membrane|microsome	phospho-N-acetylmuramoyl-pentapeptide-transferase activity|transferase activity, transferring glycosyl groups|UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity			breast(2)|ovary(1)	3	all_hematologic(175;0.0977)	Medulloblastoma(222;0.0425)|Breast(348;0.052)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;7.55e-05)		AGATCATGCAGCAGATGGCAA	0.557			NA									OREG0021396	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	12	52					0	0	0.00245	0	0
C11orf63	79864	broad.mit.edu	37	11	122805201	122805201	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr11:122805201T>C	uc001pym.2	+	5	1349	c.1052T>C	c.(1051-1053)ATG>ACG	p.M351T		NM_024806	NP_079082	Q6NUN7	CK063_HUMAN	hypothetical protein LOC79864 isoform 1	351										ovary(3)	3		Breast(109;0.00249)|Lung NSC(97;0.0177)|all_lung(97;0.018)|Medulloblastoma(222;0.0425)|all_neural(223;0.112)		BRCA - Breast invasive adenocarcinoma(274;5.34e-06)|OV - Ovarian serous cystadenocarcinoma(99;0.0311)		CCTTCTGACATGGTGAATGAC	0.418			NA											3	36					0	0	0.004672	0	0
PTPN6	5777	broad.mit.edu	37	12	7060825	7060825	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr12:7060825G>T	uc001qsb.2	+	2	304	c.62G>T	c.(61-63)CGA>CTA	p.R21L	PTPN6_uc001qsa.1_Missense_Mutation_p.R23L|PTPN6_uc010sfr.1_Intron|PTPN6_uc009zfl.1_Missense_Mutation_p.R21L|PTPN6_uc010sfs.1_5'UTR	NM_002831	NP_002822	P29350	PTN6_HUMAN	protein tyrosine phosphatase, non-receptor type	21	SH2 1.				apoptosis|cell junction assembly|G-protein coupled receptor protein signaling pathway|interferon-gamma-mediated signaling pathway|leukocyte migration|negative regulation of peptidyl-tyrosine phosphorylation|platelet activation|positive regulation of cell proliferation|positive regulation of phosphatidylinositol 3-kinase cascade|regulation of G1/S transition of mitotic cell cycle|regulation of interferon-gamma-mediated signaling pathway|regulation of type I interferon-mediated signaling pathway|T cell costimulation|type I interferon-mediated signaling pathway	cytosol|membrane|nucleus	protein binding|protein tyrosine phosphatase activity			breast(1)	1						CTCAAGGGCCGAGGTGTCCAC	0.672			NA											12	86					0.000151284	0.000168188	0.001855	1	0
PDZRN4	29951	broad.mit.edu	37	12	41587896	41587896	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr12:41587896G>A	uc010skn.1	+	3	220	c.152G>A	c.(151-153)GGA>GAA	p.G51E		NM_013377	NP_037509	Q6ZMN7	PZRN4_HUMAN	PDZ domain containing RING finger 4 isoform 2	250	PDZ 1.						ubiquitin-protein ligase activity|zinc ion binding			lung(3)|skin(3)|ovary(2)|large_intestine(1)|kidney(1)|pancreas(1)	11	all_cancers(12;0.000673)	Lung NSC(34;0.0205)|all_lung(34;0.0264)				AATCAGGAAGGAACATCGACT	0.318			NA											6	48					0	0	0.001168	0	0
TUBA1C	84790	broad.mit.edu	37	12	49666727	49666727	+	Missense_Mutation	SNP	A	A	G			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr12:49666727A>G	uc001rtt.1	+	4	1167	c.1067A>G	c.(1066-1068)AAT>AGT	p.N356S	TUBA1C_uc001rts.2_Missense_Mutation_p.N321S|TUBA1C_uc010smh.1_Missense_Mutation_p.N426S|uc010smi.1_5'UTR	NM_032704	NP_116093	Q9BQE3	TBA1C_HUMAN	tubulin alpha 6	356					'de novo' posttranslational protein folding|microtubule-based movement|protein polymerization	cytoplasm|microtubule	GTP binding|GTPase activity|protein binding|structural molecule activity				0						GTTGGCATTAATTACCAGCCT	0.552			NA											8	76					0	0	0.004482	0	0
EIF4B	1975	broad.mit.edu	37	12	53412608	53412608	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr12:53412608G>A	uc001sbh.3	+	3	384	c.178G>A	c.(178-180)GAC>AAC	p.D60N	EIF4B_uc009zmp.1_RNA|EIF4B_uc010snu.1_Missense_Mutation_p.D60N|EIF4B_uc010snv.1_Missense_Mutation_p.D60N|EIF4B_uc001sbi.2_5'UTR	NM_001417	NP_001408	P23588	IF4B_HUMAN	eukaryotic translation initiation factor 4B	60					insulin receptor signaling pathway|nuclear-transcribed mRNA poly(A) tail shortening|regulation of translational initiation	cytosol|eukaryotic translation initiation factor 4F complex	nucleotide binding|translation initiation factor activity			breast(1)|kidney(1)	2						CAGTAACGATGACGATGTGTA	0.493			NA											70	165					0	0	0.01441	0	0
DPY19L2	283417	broad.mit.edu	37	12	64055199	64055199	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr12:64055199C>A	uc001srp.1	-	4	694	c.513G>T	c.(511-513)TGG>TGT	p.W171C	DPY19L2_uc009zqk.1_RNA	NM_173812	NP_776173	Q6NUT2	D19L2_HUMAN	dpy-19-like 2	171	Helical; (Potential).				multicellular organismal development|spermatid development	integral to membrane				central_nervous_system(1)|skin(1)	2			GBM - Glioblastoma multiforme(1;2.77e-05)	GBM - Glioblastoma multiforme(28;0.044)		TCATAATCATCCACAGTCCTT	0.303			NA											13	267					1.3612e-06	1.55678e-06	0.003163	1	0
LRRIQ1	84125	broad.mit.edu	37	12	85450634	85450634	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr12:85450634G>A	uc001tac.2	+	8	2174	c.2063G>A	c.(2062-2064)AGT>AAT	p.S688N	LRRIQ1_uc001tab.1_Missense_Mutation_p.S688N|LRRIQ1_uc001taa.1_Missense_Mutation_p.S663N	NM_001079910	NP_001073379	Q96JM4	LRIQ1_HUMAN	leucine-rich repeats and IQ motif containing 1	688										ovary(4)|central_nervous_system(1)|skin(1)	6				GBM - Glioblastoma multiforme(134;0.212)		GAGGGCTTGAGTAACTATAAT	0.338			NA											28	108					0	0	0.00632	0	0
ATP8A2	51761	broad.mit.edu	37	13	26343230	26343230	+	Silent	SNP	C	C	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr13:26343230C>A	uc001uqk.2	+	26	2573	c.2431C>A	c.(2431-2433)CGG>AGG	p.R811R	ATP8A2_uc010tdi.1_Silent_p.R771R|ATP8A2_uc010tdj.1_RNA|ATP8A2_uc010aaj.1_Silent_p.R361R	NM_016529	NP_057613	Q9NTI2	AT8A2_HUMAN	ATPase, aminophospholipid transporter-like,	771	Cytoplasmic (Potential).				ATP biosynthetic process|negative regulation of cell proliferation	integral to membrane	ATP binding|ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism|magnesium ion binding|phospholipid-translocating ATPase activity			ovary(2)|large_intestine(1)|skin(1)	4		Breast(139;0.0201)|Lung SC(185;0.0225)		all cancers(112;0.043)|OV - Ovarian serous cystadenocarcinoma(117;0.0748)|Epithelial(112;0.079)		GGTGAAGAAGCGGGTGAAGGC	0.537			NA											28	49					2.65835e-16	3.55041e-16	0.007291	1	0
ELF1	1997	broad.mit.edu	37	13	41507961	41507961	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr13:41507961T>A	uc001uxs.2	-	9	1833	c.1460A>T	c.(1459-1461)CAG>CTG	p.Q487L	ELF1_uc010tfc.1_Missense_Mutation_p.Q463L|ELF1_uc010acd.2_Missense_Mutation_p.Q380L	NM_172373	NP_758961	P32519	ELF1_HUMAN	E74-like factor 1 (ets domain transcription	487					positive regulation of transcription from RNA polymerase II promoter	cytoplasm|nucleus	protein binding|sequence-specific DNA binding|sequence-specific DNA binding transcription factor activity			ovary(1)	1		Lung NSC(96;8.3e-05)|Prostate(109;0.0233)|Breast(139;0.0296)|Lung SC(185;0.0367)		all cancers(112;1.87e-08)|Epithelial(112;8.45e-06)|OV - Ovarian serous cystadenocarcinoma(117;0.000202)|GBM - Glioblastoma multiforme(144;0.00266)|BRCA - Breast invasive adenocarcinoma(63;0.072)		CTTTTGTGACTGCAGCATGAC	0.478			NA											50	159					0	0	0.01441	0	0
DIS3	22894	broad.mit.edu	37	13	73333994	73333994	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr13:73333994G>C	uc001vix.3	-	21	3190	c.2816C>G	c.(2815-2817)ACT>AGT	p.T939S	DIS3_uc001viy.3_Missense_Mutation_p.T909S|DIS3_uc001viz.2_RNA	NM_014953	NP_055768	Q9Y2L1	RRP44_HUMAN	DIS3 mitotic control isoform a	939					CUT catabolic process|exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay|rRNA catabolic process|rRNA processing	cytosol|exosome (RNase complex)|nucleolus|nucleoplasm	3'-5'-exoribonuclease activity|endonuclease activity|guanyl-nucleotide exchange factor activity|protein binding|RNA binding			central_nervous_system(1)	1		Breast(118;0.0074)|Acute lymphoblastic leukemia(28;0.0195)		GBM - Glioblastoma multiforme(99;0.000181)		TGAAGTATCAGTAGGAATGCT	0.363			NA								Multiple Myeloma(4;0.011)			19	59					0	0	0.014323	0	0
MYCBP2	23077	broad.mit.edu	37	13	77755944	77755944	+	Silent	SNP	A	A	G			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr13:77755944A>G	uc001vkf.2	-	34	4810	c.4719T>C	c.(4717-4719)GAT>GAC	p.D1573D	MYCBP2_uc010aev.2_Silent_p.D977D	NM_015057	NP_055872	O75592	MYCB2_HUMAN	MYC binding protein 2	1573					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	ligase activity|protein binding|zinc ion binding			ovary(4)|breast(4)|skin(3)|lung(2)|pancreas(1)	14		Breast(118;0.212)|Acute lymphoblastic leukemia(28;0.22)		GBM - Glioblastoma multiforme(99;0.109)		ATACTTCTCCATCATACGCAA	0.423			NA											37	85					0	0	0.004289	0	0
OR4K5	79317	broad.mit.edu	37	14	20389573	20389573	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr14:20389573T>C	uc010tkw.1	+	1	808	c.808T>C	c.(808-810)TTT>CTT	p.F270L		NM_001005483	NP_001005483	Q8NGD3	OR4K5_HUMAN	olfactory receptor, family 4, subfamily K,	270	Helical; Name=7; (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			ovary(1)|skin(1)	2	all_cancers(95;0.00108)		Epithelial(56;9.96e-07)|all cancers(55;2.95e-06)	GBM - Glioblastoma multiforme(265;0.00327)		TTTGGATAAATTTCTTGCCAT	0.388			NA											16	296					0	0	0.006122	0	0
FLJ10357	55701	broad.mit.edu	37	14	21543035	21543035	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr14:21543035G>C	uc001vzp.2	+	3	1175	c.1146G>C	c.(1144-1146)AAG>AAC	p.K382N	FLJ10357_uc001vzn.1_Missense_Mutation_p.K382N|FLJ10357_uc001vzo.1_Intron|FLJ10357_uc010aij.2_RNA|FLJ10357_uc010tln.1_5'UTR	NM_018071	NP_060541	Q8TER5	ARH40_HUMAN	hypothetical protein LOC55701	382	Gly-rich.				regulation of Rho protein signal transduction	cytoplasm	Rho guanyl-nucleotide exchange factor activity				0	all_cancers(95;0.00185)		OV - Ovarian serous cystadenocarcinoma(11;5.79e-11)|Epithelial(56;8.35e-09)|all cancers(55;4.23e-08)	GBM - Glioblastoma multiforme(265;0.0197)		ACAGAAGAAAGAAGCGAGCTG	0.627			NA											16	77					0	0	0.006122	0	0
NUBPL	80224	broad.mit.edu	37	14	32030658	32030658	+	Nonsense_Mutation	SNP	C	C	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr14:32030658C>T	uc001wrk.3	+	1	68	c.13C>T	c.(13-15)CAG>TAG	p.Q5*	NUBPL_uc010amj.2_RNA	NM_025152	NP_079428	Q8TB37	NUBPL_HUMAN	nucleotide binding protein-like	5					mitochondrial respiratory chain complex I assembly|mitochondrion morphogenesis	mitochondrion	4 iron, 4 sulfur cluster binding|ATP binding|metal ion binding				0	Hepatocellular(127;0.0604)|Prostate(35;0.15)|Breast(36;0.214)		LUAD - Lung adenocarcinoma(48;0.00192)|Lung(238;0.00714)|BRCA - Breast invasive adenocarcinoma(188;0.0677)|STAD - Stomach adenocarcinoma(7;0.173)	GBM - Glioblastoma multiforme(265;0.0102)		GGGGATTTGGCAGCGTCTGCT	0.667			NA											3	22					0	0	0.00308	0	0
RALGAPA1	253959	broad.mit.edu	37	14	36217939	36217939	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr14:36217939G>C	uc001wti.2	-	10	1494	c.1103C>G	c.(1102-1104)TCC>TGC	p.S368C	RALGAPA1_uc001wtj.2_Missense_Mutation_p.S368C|RALGAPA1_uc010tpv.1_Missense_Mutation_p.S368C|RALGAPA1_uc010tpw.1_Missense_Mutation_p.S368C|RALGAPA1_uc001wtk.1_Missense_Mutation_p.S219C	NM_014990	NP_055805	Q6GYQ0	RGPA1_HUMAN	Ral GTPase activating protein, alpha subunit 1	368					activation of Ral GTPase activity	cytosol|mitochondrion|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(3)|breast(1)	4						GCTTGTATTGGAATGAGACTG	0.393			NA											78	55					0	0	0.01441	0	0
MGAT2	4247	broad.mit.edu	37	14	50088220	50088220	+	Silent	SNP	G	G	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr14:50088220G>T	uc001wwr.2	+	1	732	c.234G>T	c.(232-234)GCG>GCT	p.A78A	SDCCAG1_uc010anj.1_Intron|RPL36AL_uc001wwq.1_5'Flank	NM_002408	NP_002399	Q10469	MGAT2_HUMAN	mannosyl (alpha-1,6-)-glycoprotein	78	Lumenal (Potential).				oligosaccharide biosynthetic process|post-translational protein modification|protein N-linked glycosylation via asparagine	Golgi membrane|Golgi stack|integral to membrane|membrane fraction	alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity				0	all_epithelial(31;0.0021)|Breast(41;0.0124)					TGGTCCCGGCGGTCCCCCAGC	0.682			NA											11	30					3.41278e-10	4.19225e-10	0.00499	1	0
ZFYVE26	23503	broad.mit.edu	37	14	68274475	68274475	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr14:68274475G>T	uc001xka.2	-	5	665	c.526C>A	c.(526-528)CTT>ATT	p.L176I	ZFYVE26_uc010tsz.1_RNA|ZFYVE26_uc001xkc.3_Missense_Mutation_p.L176I|ZFYVE26_uc010tta.1_Missense_Mutation_p.L176I	NM_015346	NP_056161	Q68DK2	ZFY26_HUMAN	zinc finger, FYVE domain containing 26	176					cell cycle|cell death|cytokinesis|double-strand break repair via homologous recombination	centrosome|midbody	metal ion binding|phosphatidylinositol-3-phosphate binding|protein binding	p.L176V(1)		ovary(9)|breast(2)	11				all cancers(60;0.000763)|OV - Ovarian serous cystadenocarcinoma(108;0.0011)|BRCA - Breast invasive adenocarcinoma(234;0.0115)		TCCTCCTCAAGCAGGAGCTCC	0.607			NA											31	182					6.70999e-13	8.55953e-13	0.004289	1	0
TDP1	55775	broad.mit.edu	37	14	90499508	90499508	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr14:90499508C>G	uc001xxy.2	+	16	2002	c.1703C>G	c.(1702-1704)GCC>GGC	p.A568G	TDP1_uc010atm.2_RNA|TDP1_uc001xxz.2_Missense_Mutation_p.A568G|TDP1_uc010atn.2_Silent_p.G583G|TDP1_uc001xya.2_Missense_Mutation_p.A329G|TDP1_uc001xyb.2_RNA|TDP1_uc010ato.2_Intron|TDP1_uc001xyd.1_Missense_Mutation_p.A183G	NM_018319	NP_060789	Q9NUW8	TYDP1_HUMAN	tyrosyl-DNA phosphodiesterase 1	568					cell death|double-strand break repair|single strand break repair	cytoplasm|nucleus	3'-tyrosyl-DNA phosphodiesterase activity|double-stranded DNA binding|exonuclease activity|protein binding|single-stranded DNA binding			ovary(2)	2		all_cancers(154;0.185)		COAD - Colon adenocarcinoma(157;0.23)		GAGCCAATGGCCACCTTTCCT	0.453			NA						Repair_of_DNA-protein_crosslinks					17	18					0	0	0.007413	0	0
SERPINA11	256394	broad.mit.edu	37	14	94914835	94914835	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr14:94914835C>A	uc001ydd.1	-	2	337	c.277G>T	c.(277-279)GCT>TCT	p.A93S		NM_001080451	NP_001073920	Q86U17	SPA11_HUMAN	serpin peptidase inhibitor, clade A (alpha-1	93					regulation of proteolysis	extracellular region	serine-type endopeptidase inhibitor activity			kidney(1)	1				COAD - Colon adenocarcinoma(157;0.211)		GAGGTGTTAGCTTGGGCCCCA	0.597			NA											22	129					8.10497e-08	9.60053e-08	0.010504	1	0
MGA	23269	broad.mit.edu	37	15	41988517	41988517	+	Nonsense_Mutation	SNP	G	G	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr15:41988517G>T	uc001zog.1	+	3	1400	c.1309G>T	c.(1309-1311)GAA>TAA	p.E437*	MGA_uc010ucy.1_Nonsense_Mutation_p.E437*|MGA_uc010ucz.1_Nonsense_Mutation_p.E437*	NM_001080541	NP_001074010	Q8IWI9	MGAP_HUMAN	MAX-interacting protein isoform 2	437						MLL1 complex	DNA binding|sequence-specific DNA binding transcription factor activity			ovary(6)|kidney(3)|upper_aerodigestive_tract(1)|haematopoietic_and_lymphoid_tissue(1)|skin(1)	12		all_cancers(109;0.00356)|all_epithelial(112;0.0413)|all_lung(180;0.18)|Ovarian(310;0.238)		OV - Ovarian serous cystadenocarcinoma(18;1.41e-18)|GBM - Glioblastoma multiforme(113;2.15e-06)|COAD - Colon adenocarcinoma(120;0.031)|Lung(196;0.0721)|BRCA - Breast invasive adenocarcinoma(123;0.0964)|Colorectal(105;0.0998)|LUSC - Lung squamous cell carcinoma(244;0.235)		TGACAACCCAGAAGCTGACCA	0.408			NA											28	31					1.08312e-15	1.42742e-15	0.009535	1	0
C15orf48	84419	broad.mit.edu	37	15	45723236	45723236	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr15:45723236G>A	uc001zvg.2	+	3	192	c.74G>A	c.(73-75)GGT>GAT	p.G25D	C15orf48_uc001zvh.2_Missense_Mutation_p.G25D|MIR147B_hsa-mir-147b|MI0005544_5'Flank	NM_197955	NP_922946	Q9C002	NMES1_HUMAN	normal mucosa of esophagus specific 1	25						nucleus				ovary(1)	1		Lung NSC(122;3.55e-06)|all_lung(180;2.56e-05)|Melanoma(134;0.027)		all cancers(107;1.67e-16)|GBM - Glioblastoma multiforme(94;1.71e-06)		GTGGCGGCGGGTGGAGCCTCA	0.423			NA											20	68					0	0	0.007291	0	0
GRINL1A	81488	broad.mit.edu	37	15	58001463	58001463	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr15:58001463C>T	uc002aet.3	+	2	805	c.665C>T	c.(664-666)TCC>TTC	p.S222F	GCOM1_uc002aem.2_Intron|GCOM1_uc002aeq.2_Intron|GCOM1_uc002aen.2_Intron|GCOM1_uc010bfy.2_Intron|GCOM1_uc002aeo.2_Intron|GCOM1_uc002aep.2_RNA|GCOM1_uc010bfx.2_Intron|GRINL1A_uc002aes.2_5'UTR|GRINL1A_uc002aev.1_3'UTR|GRINL1A_uc010ugu.1_RNA|GRINL1A_uc002aeu.3_Missense_Mutation_p.S65F	NM_015532	NP_056347	P0CAP1	GCOM1_HUMAN	glutamate receptor, ionotropic, N-methyl	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					intracellular signal transduction	extrinsic to internal side of plasma membrane|I band					0				all cancers(107;0.0697)|GBM - Glioblastoma multiforme(80;0.12)		ACAGGCCTTTCCAGTGGGACT	0.443			NA											12	56					0	0	0.001855	0	0
RPL4	6124	broad.mit.edu	37	15	66792408	66792408	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr15:66792408G>A	uc002apv.2	-	9	1080	c.1024C>T	c.(1024-1026)CGC>TGC	p.R342C	SNAPC5_uc002apu.1_5'Flank|RPL4_uc010bhr.2_Missense_Mutation_p.R248C|RPL4_uc002apw.2_Missense_Mutation_p.R248C|RPL4_uc002apx.2_Missense_Mutation_p.R248C	NM_000968	NP_000959	P36578	RL4_HUMAN	ribosomal protein L4	342					endocrine pancreas development|translational elongation|translational termination|viral transcription	cytosolic large ribosomal subunit|nucleolus	protein binding|RNA binding|structural constituent of ribosome				0						CTGGCCTGGCGAAGAATGGTG	0.299			NA											9	86					0	0	0.006214	0	0
ARID3B	10620	broad.mit.edu	37	15	74883593	74883593	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr15:74883593G>A	uc002aye.2	+	6	1184	c.983G>A	c.(982-984)CGG>CAG	p.R328Q	ARID3B_uc002ayd.2_Missense_Mutation_p.R328Q|ARID3B_uc010bjs.1_Missense_Mutation_p.R33Q	NM_006465	NP_006456	Q8IVW6	ARI3B_HUMAN	AT rich interactive domain 3B	328	Interaction with RB1.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding				0						GAGGGCCGGCGGCCCAGCTAC	0.617			NA											22	155					0	0	0.005443	0	0
LOC645752	645752	broad.mit.edu	37	15	78211648	78211648	+	Missense_Mutation	SNP	A	A	G			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr15:78211648A>G	uc010bky.2	-	11	883	c.119T>C	c.(118-120)CTA>CCA	p.L40P		NR_027024				SubName: Full=GOLGA6 protein; Flags: Fragment;												0						CGCCAGGGATAGGGGCTCAGC	0.522			NA											3	63					0	0	0.004672	0	0
ADAMTSL3	57188	broad.mit.edu	37	15	84611522	84611522	+	Silent	SNP	C	C	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr15:84611522C>T	uc002bjz.3	+	18	2516	c.2292C>T	c.(2290-2292)CAC>CAT	p.H764H	ADAMTSL3_uc010bmt.1_Silent_p.H764H|ADAMTSL3_uc010bmu.1_Silent_p.H764H	NM_207517	NP_997400	P82987	ATL3_HUMAN	ADAMTS-like 3 precursor	764	TSP type-1 6.					proteinaceous extracellular matrix	metallopeptidase activity|zinc ion binding			ovary(6)|central_nervous_system(5)|lung(5)|large_intestine(4)|breast(3)|skin(2)|kidney(1)|pancreas(1)	27			BRCA - Breast invasive adenocarcinoma(143;0.211)			CTGGCTGGCACATTGAAGAAT	0.572			NA											3	23					0	0	0.009096	0	0
EME2	197342	broad.mit.edu	37	16	1825151	1825152	+	Nonsense_Mutation	DNP	GC	GC	AA			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	GC	GC	-	-	GC	GC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr16:1825151_1825152GC>AA	uc002cmq.1	+	4	587_588	c.587_588GC>AA	c.(586-588)TGC>TAA	p.C196*	MRPS34_uc002cmn.2_5'Flank|MRPS34_uc002cmo.2_5'Flank|MRPS34_uc002cmp.1_5'Flank|EME2_uc010brw.1_Intron	NM_001010865	NP_001010865	A4GXA9	EME2_HUMAN	essential meiotic endonuclease 1 homolog 2	Error:AA_residue_mismatch_between_GAF_and_UniProt_prot_seqs_after_alignment					DNA recombination|DNA repair	nucleus	DNA binding|endonuclease activity			lung(1)|central_nervous_system(1)|pancreas(1)	3						TCACTCTCATGCCCACAGCAGG	0.668			NA						Direct_reversal_of_damage|Homologous_recombination					17	133					0	0	0.004672	0	0
C16orf62	57020	broad.mit.edu	37	16	19702685	19702685	+	Silent	SNP	C	C	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr16:19702685C>T	uc002dgn.1	+	29	2550	c.2538C>T	c.(2536-2538)AAC>AAT	p.N846N	C16orf62_uc002dgo.1_Silent_p.N753N|C16orf62_uc002dgp.1_Silent_p.N595N	NM_020314	NP_064710	Q7Z3J2	CP062_HUMAN	hypothetical protein LOC57020	846						integral to membrane				ovary(1)	1						TGGACTCCAACGACAGCCTCT	0.562			NA											9	41					0	0	0.006214	0	0
LCMT1	51451	broad.mit.edu	37	16	25175965	25175965	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr16:25175965C>G	uc002dnx.1	+	7	774	c.616C>G	c.(616-618)CCA>GCA	p.P206A	LCMT1_uc002dny.1_Missense_Mutation_p.P151A|LCMT1_uc002dnz.1_Missense_Mutation_p.P106A|LCMT1_uc002doa.1_Missense_Mutation_p.P51A	NM_016309	NP_057393	Q9UIC8	LCMT1_HUMAN	leucine carboxyl methyltransferase 1 isoform a	206							protein binding|protein C-terminal carboxyl O-methyltransferase activity|S-adenosylmethionine-dependent methyltransferase activity				0				GBM - Glioblastoma multiforme(48;0.0336)	L-Leucine(DB00149)	TTACATGACTCCAGAGCAGTC	0.438	Colon(200;565 2072 24396 47922 50898)		NA											4	108					0	0	0.009096	0	0
PRRT2	112476	broad.mit.edu	37	16	29825755	29825755	+	Silent	SNP	C	C	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr16:29825755C>A	uc002due.3	+	3	1282	c.981C>A	c.(979-981)ATC>ATA	p.I327I	uc002dtf.2_Intron|BOLA2_uc010bzb.1_Intron|uc002duc.1_5'Flank|PRRT2_uc002dud.2_Silent_p.I327I|PRRT2_uc002duf.1_3'UTR|C16orf53_uc002dug.3_5'Flank	NM_145239	NP_660282	Q7Z6L0	PRRT2_HUMAN	proline-rich transmembrane protein 2	327	Helical; (Potential).				response to biotic stimulus	integral to membrane					0						GAGTCCTCATCATCATCGCCT	0.642			NA											7	103					0.000157383	0.000173035	0.00308	1	0
SALL1	6299	broad.mit.edu	37	16	51174943	51174943	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr16:51174943G>T	uc010vgs.1	-	2	1221	c.1190C>A	c.(1189-1191)TCC>TAC	p.S397Y	SALL1_uc010vgr.1_Missense_Mutation_p.S300Y|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	397					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			CGAGTTAGCGGAGGCTTGCTG	0.498	GBM(103;1352 1446 1855 4775 8890)		NA											12	139					6.42651e-13	8.30439e-13	0.010729	1	0
SALL1	6299	broad.mit.edu	37	16	51175382	51175382	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr16:51175382G>A	uc010vgs.1	-	2	782	c.751C>T	c.(751-753)CGT>TGT	p.R251C	SALL1_uc010vgr.1_Missense_Mutation_p.R154C|SALL1_uc010cbv.2_Intron	NM_002968	NP_002959	Q9NSC2	SALL1_HUMAN	sal-like 1 isoform a	251					adrenal gland development|branching involved in ureteric bud morphogenesis|embryonic digestive tract development|embryonic digit morphogenesis|gonad development|histone deacetylation|inductive cell-cell signaling|mesenchymal to epithelial transition involved in metanephros morphogenesis|negative regulation of transcription from RNA polymerase II promoter|olfactory bulb interneuron differentiation|olfactory bulb mitral cell layer development|olfactory nerve development|outer ear morphogenesis|pituitary gland development|positive regulation of transcription from RNA polymerase II promoter|positive regulation of Wnt receptor signaling pathway|ureteric bud invasion|ventricular septum development	chromocenter|cytoplasm|heterochromatin|nucleus	beta-catenin binding|DNA binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			skin(5)|ovary(3)	8		all_cancers(37;0.0322)	COAD - Colon adenocarcinoma(2;0.24)			ATTTGGTGACGAATCTGTTCG	0.532	GBM(103;1352 1446 1855 4775 8890)		NA											10	149					0	0	0.010729	0	0
KIAA0182	23199	broad.mit.edu	37	16	85695049	85695049	+	Silent	SNP	G	G	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr16:85695049G>T	uc002fix.2	+	9	2012	c.1938G>T	c.(1936-1938)CTG>CTT	p.L646L	KIAA0182_uc002fiw.2_Silent_p.L542L|KIAA0182_uc002fiy.2_Silent_p.L573L|KIAA0182_uc002fiz.2_5'Flank|KIAA0182_uc010cho.2_5'Flank	NM_014615	NP_055430	Q14687	GSE1_HUMAN	genetic suppressor element 1 isoform 1	646	Pro-rich.						protein binding			large_intestine(3)|ovary(1)|skin(1)	5						CTGCCCCTCTGGACAAGTACC	0.706			NA											5	20					1.06961e-07	1.25949e-07	0.00308	1	0
SPATA22	84690	broad.mit.edu	37	17	3343538	3343538	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr17:3343538C>A	uc002fvm.2	-	9	1232	c.995G>T	c.(994-996)AGA>ATA	p.R332I	SPATA22_uc010vrg.1_Missense_Mutation_p.R316I|SPATA22_uc010vrf.1_3'UTR|SPATA22_uc002fvn.2_Missense_Mutation_p.R332I|SPATA22_uc002fvo.2_Missense_Mutation_p.R332I|SPATA22_uc002fvp.2_Missense_Mutation_p.R332I|SPATA22_uc010ckf.2_Missense_Mutation_p.R289I	NM_032598	NP_115987	Q8NHS9	SPT22_HUMAN	spermatogenesis associated 22	332											0						AGACGCCGGTCTGACAGAAAC	0.378			NA											7	124					5.18039e-06	5.89085e-06	0.00308	1	0
SLC13A2	9058	broad.mit.edu	37	17	26818601	26818601	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr17:26818601G>C	uc002hbh.2	+	5	788	c.721G>C	c.(721-723)GCA>CCA	p.A241P	SLC13A2_uc010wal.1_Missense_Mutation_p.A198P|SLC13A2_uc010wam.1_Missense_Mutation_p.A197P|SLC13A2_uc010wan.1_Missense_Mutation_p.A290P|SLC13A2_uc010wao.1_Missense_Mutation_p.A198P|SLC13A2_uc002hbi.2_Missense_Mutation_p.A170P	NM_003984	NP_003975	Q13183	S13A2_HUMAN	solute carrier family 13, member 2 isoform b	241	Helical; (Potential).					integral to plasma membrane|membrane fraction	low affinity sodium:dicarboxylate symporter activity				0	all_lung(13;0.000871)|Lung NSC(42;0.0027)			UCEC - Uterine corpus endometrioid carcinoma (53;0.154)	Succinic acid(DB00139)	GACTGGCACCGCACCCAACCT	0.627			NA											13	79					0	0	0.003163	0	0
RNF135	84282	broad.mit.edu	37	17	29325909	29325909	+	Silent	SNP	G	G	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr17:29325909G>A	uc002hfz.2	+	5	1135	c.999G>A	c.(997-999)GAG>GAA	p.E333E	RNF135_uc002hga.2_3'UTR|RNF135_uc010csm.2_3'UTR|RNF135_uc002hgb.2_3'UTR	NM_032322	NP_115698	Q8IUD6	RN135_HUMAN	ring finger protein 135 isoform 1	333	B30.2/SPRY.				innate immune response|negative regulation of type I interferon production|positive regulation of interferon-beta production|regulation of innate immune response	cytosol	protein binding|ribonucleoprotein binding|ubiquitin-protein ligase activity|zinc ion binding	p.?(1)		skin(2)	2		all_cancers(10;8.65e-08)|all_hematologic(16;0.00556)|Acute lymphoblastic leukemia(14;0.00593)|Myeloproliferative disorder(56;0.0255)				CTTCCTGGGAGATGAGCCGCG	0.557			NA											12	50					0	0	0.001855	0	0
CDK12	51755	broad.mit.edu	37	17	37627359	37627359	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr17:37627359T>C	uc010cvv.2	+	2	1860	c.1274T>C	c.(1273-1275)GTA>GCA	p.V425A	CDK12_uc010wef.1_Missense_Mutation_p.V424A|CDK12_uc002hrw.3_Missense_Mutation_p.V425A	NM_016507	NP_057591	Q9NYV4	CDK12_HUMAN	Cdc2-related kinase, arginine/serine-rich	425					mRNA processing|phosphorylation of RNA polymerase II C-terminal domain|protein autophosphorylation|regulation of MAP kinase activity|RNA splicing	nuclear cyclin-dependent protein kinase holoenzyme complex|nuclear speck|nucleolus	ATP binding|cyclin-dependent protein kinase activity|protein binding|RNA polymerase II carboxy-terminal domain kinase activity			ovary(10)|lung(4)|breast(2)|skin(2)|large_intestine(1)	19						GGTTCACCTGTATTTTTGCCT	0.438			NA								TCGA Ovarian(9;0.13)			23	124					0	0	0.014323	0	0
KRTAP4-9	100132386	broad.mit.edu	37	17	39261731	39261731	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr17:39261731G>C	uc010wfp.1	+	1	91	c.91G>C	c.(91-93)GAG>CAG	p.E31Q		NM_001146041	NP_001139513	Q9BYQ8	KRA49_HUMAN	keratin associated protein 4-9	31	2.|29 X 5 AA repeats of C-C-[RQVHIEK]- [SPTR]-[VSTQCRNP].					keratin filament					0						CAGCTGCTGTGAGACCACCTG	0.637			NA											3	69					0	0	0.004672	0	0
MAPT	4137	broad.mit.edu	37	17	44061120	44061120	+	Missense_Mutation	SNP	A	A	C			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr17:44061120A>C	uc002ijr.3	+	6	1270	c.950A>C	c.(949-951)CAC>CCC	p.H317P	MAPT_uc010dau.2_Missense_Mutation_p.H317P|MAPT_uc002ijs.3_Intron|MAPT_uc002ijx.3_Intron|MAPT_uc002ijt.3_Intron|MAPT_uc002iju.3_Intron|MAPT_uc002ijv.3_Intron	NM_016835	NP_058519	P10636	TAU_HUMAN	microtubule-associated protein tau isoform 1	317					cellular component disassembly involved in apoptosis|microtubule cytoskeleton organization|negative regulation of microtubule depolymerization|positive regulation of axon extension|positive regulation of microtubule polymerization|regulation of autophagy	axon|cytosol|growth cone|microtubule|microtubule associated complex|nuclear periphery|plasma membrane|tubulin complex	apolipoprotein E binding|enzyme binding|identical protein binding|lipoprotein particle binding|microtubule binding|protein binding|SH3 domain binding|structural constituent of cytoskeleton			pancreas(1)	1		Melanoma(429;0.216)				GAGCAGGCGCACTCGGAGGAG	0.647			NA											11	90					0	0	0.013537	0	0
TBX21	30009	broad.mit.edu	37	17	45822618	45822618	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr17:45822618G>C	uc002ilv.1	+	6	1705	c.1494G>C	c.(1492-1494)AAG>AAC	p.K498N		NM_013351	NP_037483	Q9UL17	TBX21_HUMAN	T-box 21	498					lymphocyte migration|multicellular organismal development|positive regulation of transcription, DNA-dependent|response to virus	nucleus	sequence-specific DNA binding transcription factor activity|transcription regulatory region DNA binding				0						GAGACTCTAAGAGGAGGCGCG	0.587			NA											12	96					0	0	0.010729	0	0
WFIKKN2	124857	broad.mit.edu	37	17	48918350	48918350	+	Silent	SNP	C	C	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr17:48918350C>T	uc002isv.3	+	2	2395	c.1701C>T	c.(1699-1701)GAC>GAT	p.D567D	WFIKKN2_uc010dbu.2_Silent_p.D474D	NM_175575	NP_783165	Q8TEU8	WFKN2_HUMAN	WFIKKN2 protein	567						extracellular region	metalloendopeptidase inhibitor activity|protein binding|serine-type endopeptidase inhibitor activity			ovary(2)|skin(1)	3			BRCA - Breast invasive adenocarcinoma(22;1.09e-08)			AGACCTGTGACGTCCTCAAGG	0.622			NA											5	58					0	0	0.00308	0	0
TYMS	7298	broad.mit.edu	37	18	670729	670729	+	Silent	SNP	C	C	G			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr18:670729C>G	uc010dka.1	+	5	733	c.594C>G	c.(592-594)CTC>CTG	p.L198L	TYMS_uc010dkb.1_Silent_p.L164L|TYMS_uc010dkc.1_Silent_p.L115L	NM_001071	NP_001062	P04818	TYSY_HUMAN	thymidylate synthase	198					DNA repair|DNA replication|phosphatidylinositol-mediated signaling|pyrimidine base metabolic process|pyrimidine nucleoside biosynthetic process|regulation of transcription involved in G1/S phase of mitotic cell cycle|response to organophosphorus	cytosol	thymidylate synthase activity				0					Capecitabine(DB01101)|Floxuridine(DB00322)|Fluorouracil(DB00544)|Gemcitabine(DB00441)|Leucovorin(DB00650)|Pemetrexed(DB00642)|Raltitrexed(DB00293)|Trifluridine(DB00432)	GCCATGCCCTCTGCCAGTTCT	0.557			NA											45	189					0	0	0.009718	0	0
SPIRE1	56907	broad.mit.edu	37	18	12546780	12546780	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr18:12546780C>G	uc002kre.2	-	3	543	c.496G>C	c.(496-498)GCT>CCT	p.A166P	SPIRE1_uc002krc.2_RNA|SPIRE1_uc010wzw.1_Missense_Mutation_p.A46P|SPIRE1_uc010wzx.1_Intron|SPIRE1_uc010wzy.1_Missense_Mutation_p.A166P	NM_001128626	NP_001122098	Q08AE8	SPIR1_HUMAN	spire homolog 1 isoform a	166	KIND.					cytoskeleton|perinuclear region of cytoplasm	actin binding				0						CTACCGTCAGCTTCCACCGTG	0.448			NA											31	192					0	0	0.013726	0	0
C18orf34	374864	broad.mit.edu	37	18	30913186	30913186	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr18:30913186C>A	uc002kxn.2	-	9	973	c.831G>T	c.(829-831)CAG>CAT	p.Q277H	C18orf34_uc010xbr.1_Missense_Mutation_p.Q277H|C18orf34_uc010dmf.1_Intron|C18orf34_uc002kxo.2_Missense_Mutation_p.Q277H|C18orf34_uc002kxp.2_Missense_Mutation_p.Q277H	NM_001105528	NP_001098998	Q5BJE1	CR034_HUMAN	hypothetical protein LOC374864 isoform 1	277	Potential.									ovary(1)	1						GTTCCTGATTCTGCTTAGAGT	0.323			NA											29	57					1.06801e-11	1.35372e-11	0.009535	1	0
DNMT1	1786	broad.mit.edu	37	19	10252742	10252742	+	Missense_Mutation	SNP	A	A	C			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr19:10252742A>C	uc002mng.2	-	29	3403	c.3223T>G	c.(3223-3225)TAC>GAC	p.Y1075D	DNMT1_uc002mne.2_5'Flank|DNMT1_uc002mnf.2_5'UTR|DNMT1_uc010xlc.1_Missense_Mutation_p.Y1091D|DNMT1_uc002mnh.2_Missense_Mutation_p.Y970D|DNMT1_uc010xld.1_Missense_Mutation_p.Y1075D	NM_001379	NP_001370	P26358	DNMT1_HUMAN	DNA (cytosine-5-)-methyltransferase 1 isoform b	1075	BAH 2.				chromatin modification|maintenance of DNA methylation|negative regulation of histone H3-K9 methylation|negative regulation of transcription from RNA polymerase II promoter|positive regulation of gene expression|positive regulation of histone H3-K4 methylation|transcription, DNA-dependent	nucleus	DNA (cytosine-5-)-methyltransferase activity|DNA binding|transcription factor binding			ovary(2)|prostate(1)|lung(1)|breast(1)|skin(1)	6			OV - Ovarian serous cystadenocarcinoma(20;1.59e-09)|Epithelial(33;2.86e-06)|all cancers(31;6.68e-06)		Azacitidine(DB00928)|Decitabine(DB01262)|Flucytosine(DB01099)|Ifosfamide(DB01181)|Procainamide(DB01035)	CCCATGGAGTACACCTGGACG	0.632			NA											3	25					0	0	0.009096	0	0
ZNF536	9745	broad.mit.edu	37	19	30935455	30935455	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr19:30935455C>A	uc002nsu.1	+	2	1124	c.986C>A	c.(985-987)GCC>GAC	p.A329D	ZNF536_uc010edd.1_Missense_Mutation_p.A329D	NM_014717	NP_055532	O15090	ZN536_HUMAN	zinc finger protein 536	329					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	zinc ion binding			ovary(7)|large_intestine(2)|skin(2)	11	Esophageal squamous(110;0.0834)					GCCGAGTCGGCCCAGGGCCAG	0.652			NA											20	253					1.85244e-09	2.23416e-09	0.00333	1	0
RHPN2	85415	broad.mit.edu	37	19	33503585	33503585	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr19:33503585C>G	uc002nuf.2	-	5	502	c.436G>C	c.(436-438)GAT>CAT	p.D146H	RHPN2_uc010xro.1_5'UTR|RHPN2_uc002nue.2_5'UTR	NM_033103	NP_149094	Q8IUC4	RHPN2_HUMAN	rhophilin, Rho GTPase binding protein 2	146	BRO1.				signal transduction	perinuclear region of cytoplasm	protein binding			central_nervous_system(5)|ovary(1)	6	Esophageal squamous(110;0.137)					GCAATTTCATCTTCATATAAA	0.398			NA											14	119					0	0	0.003163	0	0
SBSN	374897	broad.mit.edu	37	19	36018821	36018821	+	Silent	SNP	G	G	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr19:36018821G>A	uc002oae.1	-	1	433	c.363C>T	c.(361-363)AAC>AAT	p.N121N	SBSN_uc002oad.1_Silent_p.N121N	NM_198538	NP_940940	Q6UWP8	SBSN_HUMAN	suprabasin isoform 2 precursor	121	Ala/Gly/His-rich.					extracellular region				ovary(1)	1	all_lung(56;1.62e-08)|Lung NSC(56;2.47e-08)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)			GTCCAGCAGCGTTGTTGACCC	0.572			NA											7	313					0	0	0.001984	0	0
ATP4A	495	broad.mit.edu	37	19	36054337	36054337	+	Silent	SNP	C	C	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr19:36054337C>A	uc002oal.1	-	2	134	c.105G>T	c.(103-105)GGG>GGT	p.G35G		NM_000704	NP_000695	P20648	ATP4A_HUMAN	hydrogen/potassium-exchanging ATPase 4A	35	Cytoplasmic (Potential).				ATP biosynthetic process|ATP hydrolysis coupled proton transport	integral to plasma membrane	ATP binding|hydrogen:potassium-exchanging ATPase activity|magnesium ion binding			ovary(1)	1	all_lung(56;1.05e-07)|Lung NSC(56;1.63e-07)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0724)		Esomeprazole(DB00736)|Lansoprazole(DB00448)|Omeprazole(DB00338)|Pantoprazole(DB00213)|Rabeprazole(DB01129)|Trifluoperazine(DB00831)	TCTTGCCACCCCCGCCACCCG	0.602			NA											28	347					6.50621e-10	7.89473e-10	0.013726	1	0
RYR1	6261	broad.mit.edu	37	19	39025446	39025446	+	Silent	SNP	C	C	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr19:39025446C>T	uc002oit.2	+	79	11476	c.11346C>T	c.(11344-11346)ATC>ATT	p.I3782I	RYR1_uc002oiu.2_Silent_p.I3777I|RYR1_uc002oiv.1_Silent_p.I697I|RYR1_uc010xuf.1_Silent_p.I702I	NM_000540	NP_000531	P21817	RYR1_HUMAN	skeletal muscle ryanodine receptor isoform 1	3782					muscle contraction|release of sequestered calcium ion into cytosol|response to caffeine|response to hypoxia	cell cortex|cytosol|I band|integral to plasma membrane|junctional sarcoplasmic reticulum membrane|smooth endoplasmic reticulum|terminal cisterna	calcium ion binding|calmodulin binding|receptor activity|ryanodine-sensitive calcium-release channel activity			ovary(7)|pancreas(2)|breast(1)|central_nervous_system(1)|skin(1)	12	all_cancers(60;7.91e-06)		Lung(45;0.00172)|LUSC - Lung squamous cell carcinoma(53;0.00272)		Dantrolene(DB01219)	TGCAGATGATCAGTGCCTGCA	0.602			NA											3	24					0	0	0.009096	0	0
PPP1R13L	10848	broad.mit.edu	37	19	45885837	45885837	+	Nonsense_Mutation	SNP	C	C	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr19:45885837C>T	uc002pbn.2	-	12	2473	c.2396G>A	c.(2395-2397)TGG>TAG	p.W799*	PPP1R13L_uc002pbm.2_Nonsense_Mutation_p.W378*|PPP1R13L_uc002pbo.2_Nonsense_Mutation_p.W799*	NM_006663	NP_006654	Q8WUF5	IASPP_HUMAN	protein phosphatase 1, regulatory subunit 13	799	SH3.				apoptosis|regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus	transcription corepressor activity|transcription factor binding			skin(1)	1		all_neural(266;0.224)|Ovarian(192;0.231)		OV - Ovarian serous cystadenocarcinoma(262;0.0182)		CGCGGCCCACCACCAGTCGGT	0.697	Pancreas(61;1447 1663 31419 50578)		NA											18	72					0	0	0.00333	0	0
LIG1	3978	broad.mit.edu	37	19	48660337	48660337	+	Missense_Mutation	SNP	T	T	G			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr19:48660337T>G	uc002pia.1	-	5	424	c.304A>C	c.(304-306)AAT>CAT	p.N102H	LIG1_uc002phz.1_RNA|LIG1_uc002pib.1_RNA|LIG1_uc010xzf.1_Missense_Mutation_p.N102H|LIG1_uc010xzg.1_Missense_Mutation_p.N72H|LIG1_uc010xzh.1_RNA	NM_000234	NP_000225	P18858	DNLI1_HUMAN	DNA ligase I	102					anatomical structure morphogenesis|base-excision repair|cell division|DNA ligation involved in DNA repair|DNA strand elongation involved in DNA replication|double-strand break repair via homologous recombination|nucleotide-excision repair, DNA gap filling|S phase of mitotic cell cycle|telomere maintenance via recombination|telomere maintenance via semi-conservative replication|transcription-coupled nucleotide-excision repair	nucleoplasm	ATP binding|DNA binding|DNA ligase (ATP) activity|metal ion binding			large_intestine(2)|lung(1)	3		all_epithelial(76;3.1e-06)|all_lung(116;4.39e-06)|Lung NSC(112;8.96e-06)|all_neural(266;0.0189)|Ovarian(192;0.0261)|Breast(70;0.203)		OV - Ovarian serous cystadenocarcinoma(262;8.45e-05)|all cancers(93;0.000423)|Epithelial(262;0.0177)|GBM - Glioblastoma multiforme(486;0.0329)	Bleomycin(DB00290)	AGGGAAGCATTGTTCTCAGGA	0.602			NA						NER					5	191					0	0	0.001984	0	0
ZNF577	84765	broad.mit.edu	37	19	52380585	52380585	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr19:52380585C>G	uc010yde.1	-	6	624	c.233G>C	c.(232-234)GGA>GCA	p.G78A	ZNF577_uc010ydd.1_RNA|ZNF577_uc002pxx.3_Missense_Mutation_p.G78A|ZNF577_uc002pxv.2_Missense_Mutation_p.G71A|ZNF577_uc002pxw.2_Missense_Mutation_p.G71A	NM_032679	NP_116068	Q9BSK1	ZN577_HUMAN	zinc finger protein 577 isoform a	78	KRAB.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)	1		all_neural(266;0.0602)		GBM - Glioblastoma multiforme(134;0.00161)|OV - Ovarian serous cystadenocarcinoma(262;0.019)		TGGGGGTTCTCCTTGCTCCAA	0.498			NA											8	164					0	0	0.010729	0	0
CLEC4F	165530	broad.mit.edu	37	2	71036905	71036905	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr2:71036905C>G	uc002shf.2	-	6	1701	c.1624G>C	c.(1624-1626)GAT>CAT	p.D542H	CLEC4F_uc010yqv.1_Missense_Mutation_p.D542H	NM_173535	NP_775806	Q8N1N0	CLC4F_HUMAN	C-type lectin, superfamily member 13	542	Extracellular (Potential).|C-type lectin.				endocytosis	integral to membrane	receptor activity|sugar binding			ovary(5)	5						GGTGTCCCATCTGTCCAGCGC	0.552	Colon(107;10 2157 6841 26035)		NA											42	85					0	0	0.009718	0	0
SMARCAL1	50485	broad.mit.edu	37	2	217285083	217285083	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr2:217285083C>G	uc002vgc.3	+	5	1254	c.924C>G	c.(922-924)AGC>AGG	p.S308R	SMARCAL1_uc010fvf.2_RNA|SMARCAL1_uc002vgd.3_Missense_Mutation_p.S308R|SMARCAL1_uc010fvg.2_Missense_Mutation_p.S308R	NM_014140	NP_054859	Q9NZC9	SMAL1_HUMAN	SWI/SNF-related matrix-associated	308					chromatin modification|DNA metabolic process|regulation of transcription from RNA polymerase II promoter	nucleus	ATP binding|DNA binding|DNA helicase activity|DNA-dependent ATPase activity			ovary(3)|breast(3)|skin(1)	7		Renal(323;0.0458)		Epithelial(149;9.48e-06)|all cancers(144;0.000621)|LUSC - Lung squamous cell carcinoma(224;0.00829)|Lung(261;0.0111)		CCTATGGCAGCAGCGAGTCAC	0.567			NA							Schimke_Immuno-Osseous_Dysplasia				3	36					0	0	0.001168	0	0
STK36	27148	broad.mit.edu	37	2	219563551	219563551	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr2:219563551G>A	uc002viu.2	+	26	3550	c.3284G>A	c.(3283-3285)AGC>AAC	p.S1095N	STK36_uc002viv.2_Missense_Mutation_p.S1074N|STK36_uc002viw.2_Missense_Mutation_p.S273N|STK36_uc002vix.2_Missense_Mutation_p.S140N	NM_015690	NP_056505	Q9NRP7	STK36_HUMAN	serine/threonine kinase 36	1095					cilium assembly|positive regulation of hh target transcription factor activity|positive regulation of smoothened signaling pathway|post-embryonic development	aggresome|cytoplasm|focal adhesion|intermediate filament cytoskeleton|nucleus	ATP binding|protein serine/threonine kinase activity|transcription factor binding			ovary(4)|stomach(2)|lung(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)	11		Renal(207;0.0915)		Epithelial(149;9.65e-07)|all cancers(144;0.000174)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(261;0.00984)		CTGTCTCCCAGCCACTTGTCC	0.587			NA											3	77					0	0	0.004672	0	0
NGEF	25791	broad.mit.edu	37	2	233757737	233757737	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr2:233757737C>T	uc002vts.2	-	7	1261	c.1013G>A	c.(1012-1014)CGG>CAG	p.R338Q	NGEF_uc010zmm.1_Missense_Mutation_p.R61Q|NGEF_uc010fyg.1_Missense_Mutation_p.R246Q	NM_019850	NP_062824	Q8N5V2	NGEF_HUMAN	neuronal guanine nucleotide exchange factor	338	DH.				apoptosis|cell differentiation|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|nervous system development|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytosol|growth cone|plasma membrane	Rho guanyl-nucleotide exchange factor activity			ovary(3)|central_nervous_system(3)|skin(1)	7		Breast(86;0.00279)|Renal(207;0.00339)|all_hematologic(139;0.00793)|Acute lymphoblastic leukemia(138;0.0182)|all_lung(227;0.0271)|Lung NSC(271;0.0839)		Epithelial(121;8.65e-17)|BRCA - Breast invasive adenocarcinoma(100;0.00037)|LUSC - Lung squamous cell carcinoma(224;0.00813)|Lung(119;0.00984)|GBM - Glioblastoma multiforme(43;0.0604)		CTCCTCCATCCGGTGCTCCAG	0.592			NA											24	69					0	0	0.008361	0	0
RALGAPA2	57186	broad.mit.edu	37	20	20506983	20506983	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr20:20506983C>A	uc002wrz.2	-	28	3749	c.3606G>T	c.(3604-3606)CAG>CAT	p.Q1202H	RALGAPA2_uc010gcx.2_Missense_Mutation_p.Q906H|RALGAPA2_uc010zsg.1_Missense_Mutation_p.Q650H|RALGAPA2_uc002wsa.1_Translation_Start_Site	NM_020343	NP_065076	Q2PPJ7	RGPA2_HUMAN	akt substrate AS250	1202					activation of Ral GTPase activity	cytosol|nucleus	protein heterodimerization activity|Ral GTPase activator activity			ovary(1)	1						CGCAAGCTACCTGGGCCACGA	0.413			NA											3	17					0.00909568	0.009784	0.009096	1	0
CHMP4B	128866	broad.mit.edu	37	20	32440005	32440005	+	Silent	SNP	A	A	G			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr20:32440005A>G	uc002xaa.2	+	4	762	c.606A>G	c.(604-606)AAA>AAG	p.K202K		NM_176812	NP_789782	Q9H444	CHM4B_HUMAN	chromatin modifying protein 4B	202					cellular membrane organization|endosome transport|protein transport	cytosol|late endosome membrane	protein binding			ovary(1)|central_nervous_system(1)	2						TACCATCAAAACCCGGTGAGT	0.493			NA											56	259					0	0	0.01441	0	0
ZNF831	128611	broad.mit.edu	37	20	57768042	57768042	+	Silent	SNP	G	G	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr20:57768042G>T	uc002yan.2	+	1	1968	c.1968G>T	c.(1966-1968)CTG>CTT	p.L656L		NM_178457	NP_848552	Q5JPB2	ZN831_HUMAN	zinc finger protein 831	656						intracellular	nucleic acid binding|zinc ion binding			skin(13)|ovary(1)	14	all_lung(29;0.0085)					GGGCAGAACTGGGCTTTCCTC	0.582			NA											14	121					0.000151284	0.000168188	0.001855	1	0
CHRNA4	1137	broad.mit.edu	37	20	61990970	61990970	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr20:61990970C>T	uc002yes.2	-	2	336	c.158G>A	c.(157-159)CGA>CAA	p.R53Q	CHRNA4_uc002yet.1_Intron|CHRNA4_uc011aaw.1_RNA|CHRNA4_uc010gke.1_5'UTR|CHRNA4_uc002yev.1_5'UTR|CHRNA4_uc010gkf.1_5'UTR	NM_000744	NP_000735	P43681	ACHA4_HUMAN	cholinergic receptor, nicotinic, alpha 4 subunit	53	Extracellular (Potential).				B cell activation|behavioral response to nicotine|calcium ion transport|cognition|DNA repair|membrane depolarization|regulation of action potential|regulation of dopamine secretion|regulation of inhibitory postsynaptic membrane potential|response to hypoxia|response to oxidative stress|sensory perception of pain|synaptic transmission, cholinergic	cell junction|dendrite|external side of plasma membrane|membrane fraction|neuronal cell body|nicotinic acetylcholine-gated receptor-channel complex|postsynaptic membrane	acetylcholine receptor activity|nicotinic acetylcholine-activated cation-selective channel activity			central_nervous_system(1)|skin(1)	2	all_cancers(38;1.71e-10)				Nicotine(DB00184)|Varenicline(DB01273)	GGCCACGGGTCGGGACCACTT	0.647			NA											22	95					0	0	0.004656	0	0
CYYR1	116159	broad.mit.edu	37	21	27852642	27852642	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr21:27852642G>A	uc002ymd.2	-	3	605	c.283C>T	c.(283-285)CGC>TGC	p.R95C	CYYR1_uc011ack.1_RNA|CYYR1_uc002yme.2_Missense_Mutation_p.R95C	NM_052954	NP_443186	Q96J86	CYYR1_HUMAN	cysteine and tyrosine-rich 1 protein precursor	95	Cytoplasmic (Potential).					integral to membrane					0						ATGCCCACGCGGGTCGCCCTG	0.498			NA											40	150					0	0	0.00874	0	0
RWDD2B	10069	broad.mit.edu	37	21	30378852	30378852	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr21:30378852G>T	uc002yms.2	-	5	933	c.846C>A	c.(844-846)TTC>TTA	p.F282L	RWDD2B_uc002ymt.2_Missense_Mutation_p.F253L|RWDD2B_uc002ymu.2_RNA|RWDD2B_uc002ymv.2_Missense_Mutation_p.F202L	NM_016940	NP_058636	P57060	RWD2B_HUMAN	RWD domain containing 2B	282											0						CATTAACACTGAACACTTTTT	0.388			NA											18	130					6.49762e-13	8.3421e-13	0.006122	1	0
CSTB	1476	broad.mit.edu	37	21	45194608	45194608	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr21:45194608C>G	uc002zdr.2	-	2	208	c.99G>C	c.(97-99)AAG>AAC	p.K33N		NM_000100	NP_000091	P04080	CYTB_HUMAN	cystatin B	33						cytoplasm|nucleolus	cysteine-type endopeptidase inhibitor activity|protease binding				0				STAD - Stomach adenocarcinoma(101;0.168)		CAGGGAACTTCTTGTTTTCTT	0.522	Esophageal Squamous(58;831 1093 17019 29789 35147)		NA											4	184					0	0	0.001168	0	0
TRPM2	7226	broad.mit.edu	37	21	45821603	45821603	+	Silent	SNP	C	C	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr21:45821603C>T	uc002zet.1	+	17	2574	c.2361C>T	c.(2359-2361)CGC>CGT	p.R787R	TRPM2_uc002zeu.1_Silent_p.R787R|TRPM2_uc002zew.1_Silent_p.R787R|TRPM2_uc010gpt.1_Silent_p.R787R|TRPM2_uc002zex.1_Silent_p.R573R|TRPM2_uc002zey.1_Silent_p.R300R	NM_003307	NP_003298	O94759	TRPM2_HUMAN	transient receptor potential cation channel,	787	Extracellular (Potential).					integral to plasma membrane	ADP-ribose diphosphatase activity|calcium channel activity|sodium channel activity			ovary(1)|central_nervous_system(1)|pancreas(1)	3						CCGCGGCCCGCGCCCGTGCCT	0.647			NA											18	185					0	0	0.007413	0	0
KCNJ4	3761	broad.mit.edu	37	22	38824024	38824024	+	Silent	SNP	C	C	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr22:38824024C>T	uc003avs.1	-	2	211	c.114G>A	c.(112-114)AAG>AAA	p.K38K	KCNJ4_uc003avt.1_Silent_p.K38K	NM_004981	NP_004972	P48050	IRK4_HUMAN	potassium inwardly-rectifying channel J4	38	Cytoplasmic (By similarity).				synaptic transmission	basolateral plasma membrane|voltage-gated potassium channel complex	inward rectifier potassium channel activity|PDZ domain binding				0	Melanoma(58;0.0286)					AGCGCTGCGACTTGTTGCTCA	0.627			NA											114	158					0	0	0.01441	0	0
SAPS2	9701	broad.mit.edu	37	22	50875986	50875986	+	Missense_Mutation	SNP	T	T	G			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr22:50875986T>G	uc003blb.1	+	17	2157	c.1735T>G	c.(1735-1737)TTT>GTT	p.F579V	SAPS2_uc003bky.1_Missense_Mutation_p.F552V|SAPS2_uc003bkz.1_Missense_Mutation_p.F552V|SAPS2_uc003blc.2_Missense_Mutation_p.F579V|SAPS2_uc003bla.1_Missense_Mutation_p.F553V|SAPS2_uc003bld.1_Missense_Mutation_p.F111V	NM_014678	NP_055493	O75170	PP6R2_HUMAN	SAPS domain family, member 2	579						cytoplasm|intracellular membrane-bounded organelle	protein binding				0		all_cancers(38;5.78e-13)|all_epithelial(38;1.71e-11)|all_lung(38;3.89e-05)|Breast(42;0.000523)|Lung NSC(38;0.000992)|Ovarian(80;0.0221)|Hepatocellular(38;0.0691)|Lung SC(80;0.113)		BRCA - Breast invasive adenocarcinoma(115;0.222)		CGTGGATCAGTTTGGCTTCAA	0.483			NA											10	24					0	0	0.001855	0	0
SHISA5	51246	broad.mit.edu	37	3	48510922	48510922	+	Nonsense_Mutation	SNP	G	G	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr3:48510922G>A	uc003ctp.1	-	5	615	c.481C>T	c.(481-483)CAG>TAG	p.Q161*	SHISA5_uc003ctn.1_Missense_Mutation_p.S29L|SHISA5_uc003ctm.1_Nonsense_Mutation_p.Q58*|SHISA5_uc011bbk.1_Missense_Mutation_p.S69L|SHISA5_uc003cto.1_Nonsense_Mutation_p.Q130*|SHISA5_uc003ctq.1_Nonsense_Mutation_p.Q154*|SHISA5_uc003ctr.1_Nonsense_Mutation_p.Q130*|SHISA5_uc003cts.1_Nonsense_Mutation_p.Q130*|SHISA5_uc003ctt.2_Nonsense_Mutation_p.Q58*|SHISA5_uc003ctu.1_RNA|SHISA5_uc011bbl.1_Nonsense_Mutation_p.Q59*	NM_016479	NP_057563	Q8N114	SHSA5_HUMAN	scotin precursor	161	Cytoplasmic (Potential).|Pro-rich.				apoptosis|positive regulation of I-kappaB kinase/NF-kappaB cascade	endoplasmic reticulum membrane|integral to membrane|nuclear membrane	signal transducer activity|WW domain binding				0						CTTGGAGGCTGAGGATAAGGG	0.602			NA											5	73					0	0	0.000602	0	0
NISCH	11188	broad.mit.edu	37	3	52492774	52492774	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr3:52492774C>A	uc011beg.1	+	4	346	c.274C>A	c.(274-276)CTG>ATG	p.L92M	NISCH_uc003ded.3_Missense_Mutation_p.L92M|NISCH_uc003dec.1_Missense_Mutation_p.L92M	NM_007184	NP_009115	Q9Y2I1	NISCH_HUMAN	nischarin	92	PX.|Necessary for binding to phosphoinositide-3-P; not sufficient for targeting to endosomes.				apoptosis|cell communication	cytosol|early endosome|plasma membrane|recycling endosome	phosphatidylinositol binding|receptor activity			ovary(3)|central_nervous_system(1)	4				BRCA - Breast invasive adenocarcinoma(193;1.93e-05)|Kidney(197;0.00216)|KIRC - Kidney renal clear cell carcinoma(197;0.00244)|OV - Ovarian serous cystadenocarcinoma(275;0.0577)		GGAGAAGGATCTGGAGGTCTA	0.483			NA											13	100					4.36969e-10	5.33478e-10	0.001855	1	0
EPHA6	285220	broad.mit.edu	37	3	96706597	96706597	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr3:96706597G>A	uc010how.1	+	3	917	c.874G>A	c.(874-876)GTT>ATT	p.V292I	EPHA6_uc003drp.1_Missense_Mutation_p.V292I	NM_001080448	NP_001073917	Q9UF33	EPHA6_HUMAN	EPH receptor A6 isoform a	197	Ephrin-binding.|Extracellular (Potential).					integral to plasma membrane	ATP binding|ephrin receptor activity			stomach(5)|lung(4)|central_nervous_system(3)|breast(1)|skin(1)|ovary(1)|kidney(1)	16						CATTGCCCTGGTTTCAGTCCG	0.458			NA											23	247					0	0	0.003954	0	0
CD200	4345	broad.mit.edu	37	3	112068659	112068659	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr3:112068659G>C	uc003dyw.2	+	6	1014	c.870G>C	c.(868-870)CAG>CAC	p.Q290H	CD200_uc010hqd.1_Missense_Mutation_p.Q149H|CD200_uc003dyx.2_Missense_Mutation_p.Q265H|CD200_uc003dyy.2_Missense_Mutation_p.Q149H|CD200_uc003dyz.2_Missense_Mutation_p.Q191H	NM_001004196	NP_001004196	P41217	OX2G_HUMAN	CD200 antigen isoform b	265	Cytoplasmic (Potential).				regulation of immune response	integral to plasma membrane					0		Acute lymphoblastic leukemia(4;1.7e-08)|all_hematologic(4;8.82e-05)				ACCGGAATCAGGACCGAGGTG	0.363			NA											19	49					0	0	0.007413	0	0
GPR156	165829	broad.mit.edu	37	3	119886215	119886215	+	Silent	SNP	G	G	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr3:119886215G>A	uc011bjf.1	-	9	2109	c.2109C>T	c.(2107-2109)GGC>GGT	p.G703G	GPR156_uc011bjg.1_Silent_p.G699G	NM_153002	NP_694547	Q8NFN8	GP156_HUMAN	G protein-coupled receptor 156	703	Cytoplasmic (Potential).					integral to membrane|plasma membrane	G-protein coupled receptor activity|GABA-B receptor activity			ovary(1)|skin(1)	2				GBM - Glioblastoma multiforme(114;0.19)		TTGGGGCCCGGCCAGAACCAG	0.637			NA											4	107					0	0	0.009096	0	0
PARP14	54625	broad.mit.edu	37	3	122446793	122446793	+	Silent	SNP	C	C	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr3:122446793C>T	uc003efq.3	+	16	5135	c.5076C>T	c.(5074-5076)GTC>GTT	p.V1692V	PARP14_uc010hrk.2_RNA|PARP14_uc003efr.2_Silent_p.V1409V	NM_017554	NP_060024	Q460N5	PAR14_HUMAN	poly (ADP-ribose) polymerase family, member 14	1692	PARP catalytic.				regulation of transcription, DNA-dependent|transcription, DNA-dependent	cytoplasm|nucleus|plasma membrane	NAD+ ADP-ribosyltransferase activity			ovary(2)|breast(2)|lung(1)|pancreas(1)	6				GBM - Glioblastoma multiforme(114;0.0531)		TGCCACACGTCAATCGAAATG	0.502			NA											44	20					0	0	0.01441	0	0
CP	1356	broad.mit.edu	37	3	148903209	148903209	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr3:148903209G>A	uc003ewy.3	-	12	2355	c.2102C>T	c.(2101-2103)ACA>ATA	p.T701I	CP_uc011bnr.1_RNA|CP_uc003ewx.3_Missense_Mutation_p.T482I|CP_uc003ewz.2_Missense_Mutation_p.T701I	NM_000096	NP_000087	P00450	CERU_HUMAN	ceruloplasmin precursor	701	Plastocyanin-like 4.|F5/8 type A 2.				cellular iron ion homeostasis|copper ion transport|transmembrane transport	extracellular space	chaperone binding|ferroxidase activity			ovary(1)	1		Prostate(884;0.00217)|Hepatocellular(537;0.00826)|Myeloproliferative disorder(1037;0.0122)|all_neural(597;0.0189)|Melanoma(1037;0.152)	LUSC - Lung squamous cell carcinoma(72;0.0473)|Lung(72;0.0607)		Drotrecogin alfa(DB00055)	ATGATCAGTTGTAAGGCATTC	0.313			NA											70	102					0	0	0.01441	0	0
IGSF10	285313	broad.mit.edu	37	3	151155695	151155695	+	Silent	SNP	G	G	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr3:151155695G>A	uc011bod.1	-	6	6654	c.6654C>T	c.(6652-6654)CCC>CCT	p.P2218P	IGSF10_uc011bob.1_Silent_p.P245P|IGSF10_uc011boc.1_Silent_p.P197P	NM_178822	NP_849144	Q6WRI0	IGS10_HUMAN	immunoglobulin superfamily, member 10 precursor	2218	Ig-like C2-type 8.				cell differentiation|multicellular organismal development|ossification	extracellular region				skin(7)|ovary(5)|central_nervous_system(1)	13			LUSC - Lung squamous cell carcinoma(72;0.0394)|Lung(72;0.0517)			CATCCCCACTGGGATTTCGGG	0.423			NA											54	111					0	0	0.01441	0	0
YEATS2	55689	broad.mit.edu	37	3	183476724	183476724	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr3:183476724G>A	uc003fly.2	+	13	1822	c.1627G>A	c.(1627-1629)GGA>AGA	p.G543R		NM_018023	NP_060493	Q9ULM3	YETS2_HUMAN	YEATS domain containing 2	543					histone H3 acetylation|negative regulation of transcription from RNA polymerase II promoter	Ada2/Gcn5/Ada3 transcription activator complex	TBP-class protein binding			ovary(3)|large_intestine(1)	4	all_cancers(143;6.55e-10)|Ovarian(172;0.0303)		all cancers(12;2.38e-42)|Epithelial(37;1.9e-36)|OV - Ovarian serous cystadenocarcinoma(80;6.48e-22)			TAAAATTCATGGAAGTAGTTT	0.353			NA											39	101					0	0	0.009718	0	0
SDHAP1	255812	broad.mit.edu	37	3	195701285	195701285	+	Silent	SNP	G	G	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr3:195701285G>T	uc011btq.1	-	8	1208	c.579C>A	c.(577-579)CGC>CGA	p.R193R	SDHAP1_uc003fvx.3_RNA|SDHAP1_uc011btp.1_RNA					SubName: Full=cDNA FLJ56858, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial (EC 1.3.5.1);												0						GCACGACTCTGCGATGCTCAG	0.537	Ovarian(67;1158 1227 12109 20189 43170)		NA											10	35					7.93312e-07	9.12538e-07	0.00245	1	0
SDHAP1	255812	broad.mit.edu	37	3	195701304	195701304	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr3:195701304C>T	uc011btq.1	-	8	1189	c.560G>A	c.(559-561)GGC>GAC	p.G187D	SDHAP1_uc003fvx.3_RNA|SDHAP1_uc011btp.1_RNA					SubName: Full=cDNA FLJ56858, highly similar to Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial (EC 1.3.5.1);												0						AGGGCACATGCCTGACCAGAC	0.572	Ovarian(67;1158 1227 12109 20189 43170)		NA											13	45					0	0	0.00499	0	0
HGFAC	3083	broad.mit.edu	37	4	3446354	3446354	+	Nonsense_Mutation	SNP	T	T	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr4:3446354T>A	uc003ghc.2	+	7	738	c.735T>A	c.(733-735)TGT>TGA	p.C245*	HGFAC_uc010icw.2_Nonsense_Mutation_p.C245*	NM_001528	NP_001519	Q04756	HGFA_HUMAN	HGF activator preproprotein	245	EGF-like 2.				proteolysis	extracellular space	protein binding|serine-type endopeptidase activity			central_nervous_system(2)	2				UCEC - Uterine corpus endometrioid carcinoma (64;0.163)		CCCCAGCTTGTCTGAGCAGCC	0.711			NA											4	11					0	0	0.009096	0	0
LDB2	9079	broad.mit.edu	37	4	16760880	16760880	+	Missense_Mutation	SNP	T	T	G			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr4:16760880T>G	uc003goz.2	-	2	452	c.136A>C	c.(136-138)AGT>CGT	p.S46R	LDB2_uc003gpa.2_Missense_Mutation_p.S46R|LDB2_uc003gpb.2_Missense_Mutation_p.S46R|LDB2_uc011bxh.1_Missense_Mutation_p.S46R|LDB2_uc010iee.2_Missense_Mutation_p.S46R	NM_001290	NP_001281	O43679	LDB2_HUMAN	LIM domain binding 2 isoform a	46							LIM domain binding|transcription cofactor activity				0						AGGTTGTCACTATCCTGCAAA	0.413			NA											4	134					0	0	0.001168	0	0
TLR6	10333	broad.mit.edu	37	4	38829252	38829252	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr4:38829252G>C	uc003gtm.2	-	1	1909	c.1843C>G	c.(1843-1845)CTC>GTC	p.L615V	TLR6_uc010ifg.1_Missense_Mutation_p.L615V	NM_006068	NP_006059	Q9Y2C9	TLR6_HUMAN	toll-like receptor 6 precursor	615	Cytoplasmic (Potential).				activation of NF-kappaB-inducing kinase activity|cellular response to diacyl bacterial lipopeptide|defense response to bacterium|detection of diacyl bacterial lipopeptide|inflammatory response|innate immune response|MyD88-dependent toll-like receptor signaling pathway|positive regulation of I-kappaB kinase/NF-kappaB cascade|positive regulation of interleukin-6 biosynthetic process|positive regulation of JUN kinase activity|Toll signaling pathway|toll-like receptor 1 signaling pathway|toll-like receptor 2 signaling pathway|toll-like receptor 4 signaling pathway	integral to plasma membrane|phagocytic vesicle membrane	lipopeptide binding|transmembrane receptor activity			ovary(2)	2						ACCATCCTGAGATACCAGGGC	0.517			NA											24	186					0	0	0.00333	0	0
POLR2B	5431	broad.mit.edu	37	4	57889908	57889908	+	Silent	SNP	T	T	C			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr4:57889908T>C	uc003hcl.1	+	20	2890	c.2847T>C	c.(2845-2847)TAT>TAC	p.Y949Y	POLR2B_uc011cae.1_Silent_p.Y942Y|POLR2B_uc011caf.1_Silent_p.Y874Y|POLR2B_uc003hcm.1_Silent_p.Y442Y	NM_000938	NP_000929	P30876	RPB2_HUMAN	DNA directed RNA polymerase II polypeptide B	949					mRNA capping|nuclear mRNA splicing, via spliceosome|positive regulation of viral transcription|protein phosphorylation|transcription elongation from RNA polymerase II promoter|transcription initiation from RNA polymerase II promoter|transcription-coupled nucleotide-excision repair|viral reproduction	DNA-directed RNA polymerase II, core complex	DNA binding|DNA-directed RNA polymerase activity|metal ion binding|protein binding|ribonucleoside binding			ovary(2)	2	Glioma(25;0.08)|all_neural(26;0.181)					GTATTCAGTATAGACAAGAGG	0.328			NA											49	99					0	0	0.01441	0	0
UGT8	7368	broad.mit.edu	37	4	115544374	115544374	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr4:115544374A>T	uc003ibs.2	+	2	860	c.338A>T	c.(337-339)AAC>ATC	p.N113I	UGT8_uc003ibt.2_Missense_Mutation_p.N113I|UGT8_uc011cge.1_RNA	NM_001128174	NP_001121646	Q16880	CGT_HUMAN	UDP-galactose-ceramide galactosyltransferase 8	113					central nervous system development|peripheral nervous system development	integral to membrane	2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity|UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity			ovary(1)|skin(1)	2		Ovarian(17;0.156)		OV - Ovarian serous cystadenocarcinoma(123;0.000632)		TATACTAAGAACTGTGACCTG	0.448			NA											4	157					0	0	0.009096	0	0
DNAH5	1767	broad.mit.edu	37	5	13776694	13776694	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr5:13776694C>A	uc003jfd.2	-	55	9269	c.9227G>T	c.(9226-9228)AGT>ATT	p.S3076I		NM_001369	NP_001360	Q8TE73	DYH5_HUMAN	dynein, axonemal, heavy chain 5	3076	AAA 4 (By similarity).				microtubule-based movement	cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(14)|skin(13)|upper_aerodigestive_tract(1)|central_nervous_system(1)|breast(1)|pancreas(1)	31	Lung NSC(4;0.00476)					TCGGACCCGACTCATGAAGTA	0.463			NA							Kartagener_syndrome				31	129					5.90632e-09	7.08047e-09	0.012213	1	0
FBXL7	23194	broad.mit.edu	37	5	15928521	15928521	+	Missense_Mutation	SNP	T	T	G			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr5:15928521T>G	uc003jfn.1	+	3	1131	c.650T>G	c.(649-651)CTG>CGG	p.L217R		NM_012304	NP_036436	Q9UJT9	FBXL7_HUMAN	F-box and leucine-rich repeat protein 7	217	LRR 2.				ubiquitin-dependent protein catabolic process	ubiquitin ligase complex	protein binding|ubiquitin-protein ligase activity			ovary(2)|lung(1)	3						CTGAGGCGACTGGAAGTCTCA	0.562			NA											22	87					0	0	0.004656	0	0
MEGF10	84466	broad.mit.edu	37	5	126676236	126676236	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr5:126676236C>A	uc003kuh.3	+	5	595	c.233C>A	c.(232-234)ACA>AAA	p.T78K	MEGF10_uc010jdc.1_Missense_Mutation_p.T78K|MEGF10_uc010jdd.1_Missense_Mutation_p.T78K|MEGF10_uc003kui.3_Missense_Mutation_p.T78K	NM_032446	NP_115822	Q96KG7	MEG10_HUMAN	multiple EGF-like-domains 10 precursor	78	Extracellular (Potential).|Necessary for interaction with AP2M1, self-assembly and formation of the irregular, mosaic-like adhesion pattern.|EMI.				cell adhesion|phagocytosis	basolateral plasma membrane|cell projection|integral to membrane|phagocytic cup				ovary(4)	4		Prostate(80;0.165)	KIRC - Kidney renal clear cell carcinoma(527;0.0268)|Kidney(363;0.0488)	OV - Ovarian serous cystadenocarcinoma(64;0.0657)|Epithelial(69;0.123)		AGCTATCGGACAGCCTATCGA	0.373			NA											12	72					2.27111e-07	2.64299e-07	0.013537	1	0
PCDHA7	56141	broad.mit.edu	37	5	140214302	140214302	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr5:140214302A>T	uc003lhq.2	+	1	334	c.334A>T	c.(334-336)AGG>TGG	p.R112W	PCDHA1_uc003lha.2_Intron|PCDHA1_uc003lhb.2_Intron|PCDHA2_uc003lhd.2_Intron|PCDHA3_uc003lhf.2_Intron|PCDHA4_uc003lhi.2_Intron|PCDHA4_uc003lhh.1_Intron|PCDHA5_uc003lhk.1_Intron|PCDHA5_uc003lhl.2_Intron|PCDHA6_uc003lhn.2_Intron|PCDHA6_uc003lho.2_Intron|PCDHA7_uc011dac.1_Missense_Mutation_p.R112W	NM_018910	NP_061733	Q9UN72	PCDA7_HUMAN	protocadherin alpha 7 isoform 1 precursor	112	Cadherin 1.|Extracellular (Potential).				homophilic cell adhesion|nervous system development	integral to plasma membrane	calcium ion binding|protein binding			ovary(2)|skin(2)	4			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			GATCGTGGAAAGGCCGCTGCA	0.562	NSCLC(160;258 2013 5070 22440 28951)		NA											36	363					0	0	0.009718	0	0
FBXO38	81545	broad.mit.edu	37	5	147782066	147782066	+	Silent	SNP	A	A	G			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr5:147782066A>G	uc003lpf.1	+	5	702	c.582A>G	c.(580-582)TTA>TTG	p.L194L	FBXO38_uc003lpg.1_Silent_p.L194L|FBXO38_uc003lph.2_Silent_p.L194L	NM_205836	NP_995308	Q6PIJ6	FBX38_HUMAN	F-box protein 38 isoform b	194						cytoplasm|nucleus				ovary(4)|skin(2)	6			KIRC - Kidney renal clear cell carcinoma(527;0.00112)|Kidney(363;0.00191)			TTCAAACTTTACATTTAGTTG	0.318			NA											28	55					0	0	0.007291	0	0
RANBP17	64901	broad.mit.edu	37	5	170319516	170319516	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr5:170319516G>A	uc003mba.2	+	4	398	c.382G>A	c.(382-384)GTC>ATC	p.V128I	RANBP17_uc003max.1_RNA|RANBP17_uc003may.1_RNA|RANBP17_uc003maz.1_RNA|RANBP17_uc010jjr.1_RNA|RANBP17_uc003maw.2_Missense_Mutation_p.V128I|RANBP17_uc011dew.1_Missense_Mutation_p.V128I	NM_022897	NP_075048	Q9H2T7	RBP17_HUMAN	RAN binding protein 17	128					mRNA transport|protein import into nucleus|transmembrane transport	cytoplasm|nuclear pore	GTP binding|protein transporter activity			ovary(2)|central_nervous_system(1)	3	Renal(175;0.000159)|Lung NSC(126;0.00751)|all_lung(126;0.0123)	Medulloblastoma(196;0.0399)|all_neural(177;0.0966)	Kidney(164;7.24e-05)|KIRC - Kidney renal clear cell carcinoma(164;0.000516)			AGACCAATTTGTCTTCAGAGA	0.388			NA	T	TRD@	ALL								61	156					0	0	0.01441	0	0
SCGN	10590	broad.mit.edu	37	6	25665258	25665258	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr6:25665258C>G	uc003nfb.2	+	4	537	c.334C>G	c.(334-336)CAG>GAG	p.Q112E	SCGN_uc010jpz.2_Missense_Mutation_p.C21W	NM_006998	NP_008929	O76038	SEGN_HUMAN	secretagogin precursor	112	EF-hand 3.					extracellular region|transport vesicle membrane	calcium ion binding			ovary(2)|pancreas(1)	3						GGAGTTTATGCAGGTGAGTGC	0.512			NA											11	80					0	0	0.008291	0	0
BAT3	7917	broad.mit.edu	37	6	31612875	31612875	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr6:31612875G>C	uc003nvg.3	-	10	1549	c.1235C>G	c.(1234-1236)TCC>TGC	p.S412C	BAT3_uc003nvf.3_Missense_Mutation_p.S406C|BAT3_uc003nvh.3_Missense_Mutation_p.S406C|BAT3_uc003nvi.3_Missense_Mutation_p.S406C|BAT3_uc011dnw.1_Missense_Mutation_p.S406C|BAT3_uc011dnx.1_Missense_Mutation_p.S406C|BAT3_uc003nvj.1_Missense_Mutation_p.S406C	NM_004639	NP_004630	P46379	BAG6_HUMAN	HLA-B associated transcript-3 isoform a	412	Pro-rich.|4 X 29 AA approximate repeats.				apoptosis in response to endoplasmic reticulum stress|brain development|cell differentiation|chromatin modification|DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis|embryo development|internal peptidyl-lysine acetylation|kidney development|lung development|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|protein stabilization|spermatogenesis|synaptonemal complex assembly|tail-anchored membrane protein insertion into ER membrane|transport|ubiquitin-dependent protein catabolic process	BAT3 complex|nucleus	polyubiquitin binding|proteasome binding|ribosome binding				0						CGGAGCCACGGATGAGGCCTG	0.657			NA											17	144					0	0	0.008871	0	0
SFRS18	25957	broad.mit.edu	37	6	99848691	99848691	+	Nonsense_Mutation	SNP	G	G	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr6:99848691G>A	uc003ppo.3	-	12	2371	c.2143C>T	c.(2143-2145)CGA>TGA	p.R715*	SFRS18_uc003ppl.2_Nonsense_Mutation_p.R261*|SFRS18_uc003ppp.3_Nonsense_Mutation_p.R715*|SFRS18_uc011eag.1_Nonsense_Mutation_p.R715*	NM_032870	NP_116259	Q8TF01	PNISR_HUMAN	splicing factor, arginine/serine-rich 130	715						nuclear speck					0		all_cancers(76;1.24e-06)|Acute lymphoblastic leukemia(125;4.99e-11)|all_hematologic(75;5.82e-08)|all_epithelial(107;0.00716)|Colorectal(196;0.0691)|Lung NSC(302;0.186)		BRCA - Breast invasive adenocarcinoma(108;0.0631)		TCACTTTCTCGTTTCCTTTTT	0.224			NA											6	59					0	0	0.001984	0	0
TAGAP	117289	broad.mit.edu	37	6	159464670	159464670	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr6:159464670A>T	uc003qrz.2	-	4	431	c.99T>A	c.(97-99)CAT>CAA	p.H33Q	TAGAP_uc011eft.1_5'Flank|TAGAP_uc003qsa.2_5'UTR|TAGAP_uc003qsb.2_Missense_Mutation_p.H33Q|uc003qsc.2_Intron	NM_054114	NP_473455	Q8N103	TAGAP_HUMAN	T-cell activation Rho GTPase-activating protein	33					regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol	GTPase activator activity|guanyl-nucleotide exchange factor activity			ovary(1)	1		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;2.16e-16)|BRCA - Breast invasive adenocarcinoma(81;5.87e-06)		CCAACAGGGGATGTTCCTTGA	0.373			NA											9	339					0	0	0.004482	0	0
MRPL18	29074	broad.mit.edu	37	6	160218467	160218467	+	Nonsense_Mutation	SNP	C	C	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr6:160218467C>T	uc003qsw.3	+	3	516	c.388C>T	c.(388-390)CGA>TGA	p.R130*	MRPL18_uc010kkb.2_RNA|PNLDC1_uc003qsx.1_5'Flank|PNLDC1_uc003qsy.1_5'Flank	NM_014161	NP_054880	Q9H0U6	RM18_HUMAN	mitochondrial ribosomal protein L18 precursor	130					rRNA transport|translation	mitochondrial ribosome	5S rRNA binding|structural constituent of ribosome				0		Breast(66;0.000776)|Ovarian(120;0.0303)		OV - Ovarian serous cystadenocarcinoma(65;1.44e-18)|BRCA - Breast invasive adenocarcinoma(81;5.79e-06)		GAGTATAGGACGAGTGCTGGC	0.493			NA											20	74					0	0	0.003954	0	0
SUN1	23353	broad.mit.edu	37	7	901102	901102	+	Splice_Site	SNP	G	G	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr7:901102G>A	uc011jvp.1	+	16	1943	c.1864_splice	c.e16+1	p.G622_splice	GET4_uc003sjj.1_Splice_Site|SUN1_uc003sjf.2_Splice_Site_p.G539_splice|SUN1_uc011jvq.1_Splice_Site_p.G519_splice|SUN1_uc003sjg.2_Splice_Site_p.G527_splice|SUN1_uc011jvr.1_Splice_Site_p.G420_splice|SUN1_uc003sji.2_Splice_Site_p.G460_splice|SUN1_uc003sjk.2_Splice_Site_p.G261_splice	NM_001130965	NP_001124437	O94901	SUN1_HUMAN	unc-84 homolog A isoform a						cytoskeletal anchoring at nuclear membrane|nuclear matrix anchoring at nuclear membrane	integral to membrane|nuclear inner membrane|SUN-KASH complex	protein binding				0						GAATCTGGTGGTGAGTAAATA	0.507			NA											62	80					0	0	0.01441	0	0
DNAH11	8701	broad.mit.edu	37	7	21784217	21784217	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr7:21784217A>T	uc003svc.2	+	51	8368	c.8337A>T	c.(8335-8337)GAA>GAT	p.E2779D		NM_003777	NP_003768	Q96DT5	DYH11_HUMAN	dynein, axonemal, heavy chain 11	2779					microtubule-based movement	axonemal dynein complex|cilium axoneme|cytoplasm|microtubule	ATP binding|ATPase activity|microtubule motor activity			ovary(8)|large_intestine(3)|pancreas(3)|central_nervous_system(1)	15						AATATTTTGAAGTAAGCGTAT	0.388			NA							Kartagener_syndrome				11	92					0	0	0.008291	0	0
VPS41	27072	broad.mit.edu	37	7	38791781	38791781	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr7:38791781C>T	uc003tgy.2	-	22	1947	c.1921G>A	c.(1921-1923)GAA>AAA	p.E641K	VPS41_uc003tgz.2_Missense_Mutation_p.E616K|VPS41_uc010kxn.2_Missense_Mutation_p.E552K	NM_014396	NP_055211	P49754	VPS41_HUMAN	vacuolar protein sorting 41 isoform 1	641	Clathrin.				Golgi vesicle transport|intracellular protein transport|vesicle-mediated transport	cytosol|Golgi-associated vesicle|HOPS complex|membrane fraction	zinc ion binding			skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	4						CTTACCTTTTCAAGTGGGCAA	0.423			NA											5	275					0	0	0.000602	0	0
GLI3	2737	broad.mit.edu	37	7	42006187	42006187	+	Silent	SNP	C	C	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr7:42006187C>T	uc011kbh.1	-	15	2575	c.2484G>A	c.(2482-2484)CCG>CCA	p.P828P	GLI3_uc011kbg.1_Silent_p.P769P	NM_000168	NP_000159	P10071	GLI3_HUMAN	GLI-Kruppel family member GLI3	828					negative regulation of alpha-beta T cell differentiation|negative regulation of canonical Wnt receptor signaling pathway|negative regulation of smoothened signaling pathway|negative regulation of transcription from RNA polymerase II promoter|negative thymic T cell selection|positive regulation of alpha-beta T cell differentiation|positive regulation of transcription from RNA polymerase II promoter|thymocyte apoptosis	cilium|cytosol|nucleolus	beta-catenin binding|histone acetyltransferase binding|histone deacetylase binding|sequence-specific DNA binding transcription factor activity|zinc ion binding			lung(11)|ovary(3)|large_intestine(2)|central_nervous_system(1)|kidney(1)|pancreas(1)	19						CGCTTCTGCCCGGGAGAAGCG	0.592			NA							Greig_Cephalopolysyndactyly|Pallister-Hall_syndrome				20	195					0	0	0.012319	0	0
PKD1L1	168507	broad.mit.edu	37	7	47917203	47917203	+	Missense_Mutation	SNP	C	C	G			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr7:47917203C>G	uc003tny.1	-	22	3547	c.3547G>C	c.(3547-3549)GCT>CCT	p.A1183P		NM_138295	NP_612152	Q8TDX9	PK1L1_HUMAN	polycystin-1L1	1183	Extracellular (Potential).|REJ.				cell-cell adhesion	integral to membrane				ovary(8)|upper_aerodigestive_tract(2)|breast(1)	11						TACAGCTGAGCTTTACCCAGT	0.498			NA											7	86					0	0	0.001984	0	0
SRCRB4D	136853	broad.mit.edu	37	7	76026893	76026893	+	Silent	SNP	G	G	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr7:76026893G>A	uc003ufb.2	-	6	1158	c.810C>T	c.(808-810)AGC>AGT	p.S270S	ZP3_uc003ufc.3_5'UTR	NM_080744	NP_542782	Q8WTU2	SRB4D_HUMAN	scavenger receptor cysteine rich domain	270	SRCR 2.					extracellular region|membrane	scavenger receptor activity			pancreas(1)	1						CCCAGCCCAGGCTCTGGCAGG	0.726			NA											5	6					0	0	0.010729	0	0
SEMA3D	223117	broad.mit.edu	37	7	84702345	84702345	+	Missense_Mutation	SNP	A	A	C			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr7:84702345A>C	uc003uic.2	-	4	468	c.428T>G	c.(427-429)ATA>AGA	p.I143R	SEMA3D_uc010led.2_Missense_Mutation_p.I143R|SEMA3D_uc010lee.1_Missense_Mutation_p.I143R	NM_152754	NP_689967	O95025	SEM3D_HUMAN	semaphorin 3D precursor	143	Sema.				cell differentiation|nervous system development	extracellular region|membrane	receptor activity			ovary(3)|large_intestine(2)	5						ACACACATATATGTGAGTTTT	0.343	Ovarian(63;442 1191 17318 29975 31528)		NA											18	63					0	0	0.008871	0	0
ZNF804B	219578	broad.mit.edu	37	7	88966114	88966114	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr7:88966114C>T	uc011khi.1	+	4	4356	c.3818C>T	c.(3817-3819)GCT>GTT	p.A1273V		NM_181646	NP_857597	A4D1E1	Z804B_HUMAN	zinc finger protein 804B	1273						intracellular	zinc ion binding			ovary(5)|skin(3)|pancreas(2)|upper_aerodigestive_tract(1)	11	all_hematologic(106;0.125)|Lung NSC(181;0.15)|all_lung(186;0.151)		STAD - Stomach adenocarcinoma(171;0.0513)			TTAGTAGCTGCTACCCCCTTC	0.473			NA								HNSCC(36;0.09)			83	229					0	0	0.01441	0	0
LAMB1	3912	broad.mit.edu	37	7	107615484	107615484	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr7:107615484C>T	uc003vew.2	-	12	1764	c.1429G>A	c.(1429-1431)GGT>AGT	p.G477S	LAMB1_uc003vev.2_Missense_Mutation_p.G501S|LAMB1_uc003vex.2_Missense_Mutation_p.G477S|LAMB1_uc010ljn.1_Missense_Mutation_p.G563S	NM_002291	NP_002282	P07942	LAMB1_HUMAN	laminin, beta 1 precursor	477	Laminin EGF-like 4.				axon guidance|odontogenesis|positive regulation of cell migration|positive regulation of epithelial cell proliferation|substrate adhesion-dependent cell spreading	extracellular space|laminin-1 complex|laminin-10 complex|laminin-2 complex|laminin-8 complex|perinuclear region of cytoplasm	extracellular matrix structural constituent			ovary(4)|skin(2)|upper_aerodigestive_tract(1)|central_nervous_system(1)	8					Alteplase(DB00009)|Anistreplase(DB00029)|Reteplase(DB00015)|Tenecteplase(DB00031)	TAGCAGTGACCTGTCTCGGAA	0.483			NA											28	32					0	0	0.008361	0	0
RNF148	378925	broad.mit.edu	37	7	122342609	122342609	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr7:122342609A>T	uc003vkk.1	-	1	413	c.196T>A	c.(196-198)TCT>ACT	p.S66T	CADPS2_uc010lkp.2_Intron|CADPS2_uc010lkq.2_Intron|RNF148_uc010lkr.1_Intron	NM_198085	NP_932351	Q8N7C7	RN148_HUMAN	ring finger protein 148 precursor	66	PA.					integral to membrane	zinc ion binding				0						TCCAGAGGAGAATGATTCCCG	0.468			NA											16	108					0	0	0.004007	0	0
UBN2	254048	broad.mit.edu	37	7	138957090	138957090	+	Missense_Mutation	SNP	T	T	C			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr7:138957090T>C	uc011kqr.1	+	9	1619	c.1619T>C	c.(1618-1620)CTG>CCG	p.L540P	UBN2_uc003vuv.2_Missense_Mutation_p.L263P	NM_173569	NP_775840	Q6ZU65	UBN2_HUMAN	ubinuclein 2	540										ovary(1)|skin(1)	2						AGAGAACCTCTGCAAAAACTG	0.373			NA											32	158					0	0	0.012213	0	0
MLL3	58508	broad.mit.edu	37	7	151927085	151927085	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr7:151927085C>A	uc003wla.2	-	18	3118	c.2899G>T	c.(2899-2901)GGC>TGC	p.G967C	MLL3_uc003wkz.2_Missense_Mutation_p.G28C	NM_170606	NP_733751	Q8NEZ4	MLL3_HUMAN	myeloid/lymphoid or mixed-lineage leukemia 3	967	PHD-type 4.				intracellular signal transduction|regulation of transcription, DNA-dependent|transcription, DNA-dependent		DNA binding|protein binding|zinc ion binding			large_intestine(27)|pancreas(13)|ovary(9)|central_nervous_system(8)|breast(3)|upper_aerodigestive_tract(1)|urinary_tract(1)|skin(1)	63	all_neural(206;0.187)	all_hematologic(28;0.0592)|Prostate(32;0.0906)	OV - Ovarian serous cystadenocarcinoma(82;0.00715)	UCEC - Uterine corpus endometrioid carcinoma (81;0.0597)|BRCA - Breast invasive adenocarcinoma(188;0.0462)		GCTCCTTGGCCAAAACTGCCA	0.343	Colon(68;14 1149 1884 27689 34759)		NA	N		medulloblastoma								10	350					2.61681e-11	3.29586e-11	0.00245	1	0
CLVS1	157807	broad.mit.edu	37	8	62289222	62289222	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr8:62289222G>T	uc003xuh.2	+	3	838	c.514G>T	c.(514-516)GAT>TAT	p.D172Y	CLVS1_uc003xug.2_3'UTR|CLVS1_uc003xui.2_RNA|CLVS1_uc010lyp.2_Missense_Mutation_p.D172Y	NM_173519	NP_775790	Q8IUQ0	CLVS1_HUMAN	retinaldehyde binding protein 1-like 1	172	CRAL-TRIO.				lysosome organization	clathrin-coated vesicle|early endosome membrane|trans-Golgi network	phosphatidylinositol-3,5-bisphosphate binding|transporter activity			skin(4)|ovary(1)	5						CCTAATCGAAGATCCGGAGCT	0.443			NA											24	182					3.6726e-16	4.87232e-16	0.003954	1	0
C8orf45	157777	broad.mit.edu	37	8	67796088	67796088	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr8:67796088C>T	uc003xwz.3	+	9	1103	c.932C>T	c.(931-933)TCA>TTA	p.S311L	C8orf45_uc003xwv.2_Missense_Mutation_p.S311L|C8orf45_uc011lev.1_Missense_Mutation_p.S311L|C8orf45_uc011lew.1_Missense_Mutation_p.S242L|C8orf45_uc011lex.1_Missense_Mutation_p.S69L|C8orf45_uc003xwy.3_Missense_Mutation_p.S311L	NM_173518	NP_775789	Q4G0Z9	CH045_HUMAN	minichromosome maintenance complex	311					DNA replication		ATP binding|DNA binding			ovary(1)	1	Breast(64;0.186)		Epithelial(68;0.00384)|OV - Ovarian serous cystadenocarcinoma(28;0.00913)|all cancers(69;0.0175)|BRCA - Breast invasive adenocarcinoma(89;0.206)			ATCTTTGCATCACAAATTACC	0.433			NA											5	157					0	0	0.001168	0	0
RIMS2	9699	broad.mit.edu	37	8	105263321	105263321	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr8:105263321G>T	uc003yls.2	+	27	4056	c.3815G>T	c.(3814-3816)AGA>ATA	p.R1272I	RIMS2_uc003ylp.2_Missense_Mutation_p.R1254I|RIMS2_uc003ylw.2_Missense_Mutation_p.R1261I|RIMS2_uc003ylq.2_Missense_Mutation_p.R1068I|RIMS2_uc003ylr.2_Missense_Mutation_p.R1093I	NM_014677	NP_055492	Q9UQ26	RIMS2_HUMAN	regulating synaptic membrane exocytosis 2	1316	C2 2.				intracellular protein transport	cell junction|presynaptic membrane	metal ion binding|Rab GTPase binding			ovary(6)|lung(2)|breast(2)|skin(2)|large_intestine(1)|central_nervous_system(1)|pancreas(1)	15			OV - Ovarian serous cystadenocarcinoma(57;7.7e-07)|STAD - Stomach adenocarcinoma(118;0.229)			AAAGTGGCAAGAAAAACGCTG	0.388			NA								HNSCC(12;0.0054)			54	13					7.34454e-26	9.94262e-26	0.01441	1	0
PRUNE2	158471	broad.mit.edu	37	9	79324375	79324375	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr9:79324375C>A	uc010mpk.2	-	8	2939	c.2815G>T	c.(2815-2817)GAT>TAT	p.D939Y		NM_015225	NP_056040	Q8WUY3	PRUN2_HUMAN	prune homolog 2	939					apoptosis|G1 phase|induction of apoptosis	cytoplasm	metal ion binding|pyrophosphatase activity				0						AAGAAGGAATCTTCCCAAGGA	0.423			NA											81	144					7.7321e-48	1.06116e-47	0.01441	1	0
DBC1	1620	broad.mit.edu	37	9	122000956	122000956	+	Missense_Mutation	SNP	G	G	A	rs1473785		TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr9:122000956G>A	uc004bkc.2	-	5	1118	c.662C>T	c.(661-663)ACG>ATG	p.T221M	DBC1_uc004bkd.2_Missense_Mutation_p.T221M	NM_014618	NP_055433	O60477	DBC1_HUMAN	deleted in bladder cancer 1 precursor	221	MACPF.				cell cycle arrest|cell death	cytoplasm	protein binding			skin(3)|ovary(2)|central_nervous_system(2)|large_intestine(1)	8						TTTGCTCTCCGTGCTTTGCAG	0.512			NA											18	42					0	0	0.008871	0	0
FCN1	2219	broad.mit.edu	37	9	137806617	137806617	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr9:137806617G>T	uc004cfi.2	-	3	348	c.256C>A	c.(256-258)CCA>ACA	p.P86T		NM_002003	NP_001994	O00602	FCN1_HUMAN	ficolin 1 precursor	86	Collagen-like.				opsonization|signal transduction	collagen|extracellular space	antigen binding|calcium ion binding|receptor binding|sugar binding			large_intestine(1)|ovary(1)	2		Myeloproliferative disorder(178;0.0333)		OV - Ovarian serous cystadenocarcinoma(145;3.46e-08)|Epithelial(140;6.01e-08)|all cancers(34;3.69e-07)		GGCCCCACTGGTCCTGCCTTT	0.498			NA											3	16					0.000602214	0.000651308	0.000602	1	0
YY2	404281	broad.mit.edu	37	X	21861374	21861374	+	Silent	SNP	T	T	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chrX:21861374T>A	uc010nfq.2	+	2	359	c.162T>A	c.(160-162)ACT>ACA	p.T54T	MBTPS2_uc004dae.2_Silent_p.T54T|MBTPS2_uc004dab.2_Silent_p.T54T	NM_206923	NP_996806	O15391	TYY2_HUMAN	YY2 transcription factor	Error:Variant_position_missing_in_O15391_after_alignment					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus|plasma membrane	DNA binding|zinc ion binding			breast(1)|skin(1)	2						GATGGCAAACTGCTGTTTTCA	0.403			NA											39	215					0	0	0.005524	0	0
FAM48B1	100130302	broad.mit.edu	37	X	24381622	24381622	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chrX:24381622C>T	uc011mjx.1	+	1	745	c.745C>T	c.(745-747)CCA>TCA	p.P249S		NM_001136234	NP_001129706			hypothetical protein LOC100130302											kidney(1)	1						CTCTGTAAAGCCACAGCAGGA	0.512			NA											22	156					0	0	0.00333	0	0
CYBB	1536	broad.mit.edu	37	X	37651312	37651312	+	Missense_Mutation	SNP	G	G	C			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chrX:37651312G>C	uc004ddr.2	+	4	398	c.337G>C	c.(337-339)GCG>CCG	p.A113P	CYBB_uc011mke.1_RNA|CYBB_uc011mkf.1_Missense_Mutation_p.A81P|CYBB_uc011mkg.1_5'UTR	NM_000397	NP_000388	P04839	CY24B_HUMAN	cytochrome b-245 beta polypeptide	113	Ferric oxidoreductase.|Helical; (Potential).				electron transport chain|inflammatory response|innate immune response|respiratory burst|superoxide anion generation	NADPH oxidase complex	electron carrier activity|flavin adenine dinucleotide binding|heme binding|protein heterodimerization activity|superoxide-generating NADPH oxidase activity|voltage-gated ion channel activity			central_nervous_system(1)|skin(1)	2						ACTTCACTCTGGTAAGTTTAT	0.388			NA											10	56					0	0	0.010729	0	0
ZNF630	57232	broad.mit.edu	37	X	47919181	47919181	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chrX:47919181G>T	uc004div.3	-	5	902	c.650C>A	c.(649-651)GCT>GAT	p.A217D	ZNF630_uc010nhz.1_Intron|ZNF630_uc004diw.2_Missense_Mutation_p.A93D	NM_001037735	NP_001032824	Q2M218	ZN630_HUMAN	zinc finger protein 630	217					regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	DNA binding|zinc ion binding			ovary(1)|lung(1)	2						AGAACAGGAAGCATTATACTT	0.408			NA											8	104					0.000157383	0.000173035	0.00308	1	0
MTMR8	55613	broad.mit.edu	37	X	63488494	63488494	+	Missense_Mutation	SNP	C	C	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chrX:63488494C>T	uc004dvs.2	-	14	2106	c.2038G>A	c.(2038-2040)GGG>AGG	p.G680R	MTMR8_uc011mou.1_Intron	NM_017677	NP_060147	Q96EF0	MTMR8_HUMAN	myotubularin related protein 8	680						nuclear envelope	protein tyrosine phosphatase activity			ovary(2)|breast(2)	4						CCCATGTCCCCAGAGAAACCC	0.537			NA											15	38					0	0	0.004007	0	0
KIF4A	24137	broad.mit.edu	37	X	69563564	69563564	+	Silent	SNP	G	G	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chrX:69563564G>A	uc004dyg.2	+	12	1405	c.1278G>A	c.(1276-1278)GCG>GCA	p.A426A	KIF4A_uc010nkw.2_Silent_p.A426A|KIF4A_uc004dyf.1_Silent_p.A426A	NM_012310	NP_036442	O95239	KIF4A_HUMAN	kinesin family member 4	426	Potential.				anterograde axon cargo transport|axon guidance|blood coagulation|organelle organization	chromosome|cytosol|midbody|nuclear matrix|spindle microtubule	ATP binding|DNA binding|microtubule motor activity|protein binding			ovary(4)	4						CAGAGCAAGCGAATGAAAAAA	0.448			NA											8	59					0	0	0.00308	0	0
SNX12	29934	broad.mit.edu	37	X	70288110	70288110	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chrX:70288110G>A	uc004dyr.1	-	1	122	c.47C>T	c.(46-48)CCG>CTG	p.P16L	SNX12_uc004dyp.1_RNA	NM_013346	NP_037478	Q9UMY4	SNX12_HUMAN	sorting nexin 12	16					cell communication|protein transport	membrane	phosphatidylinositol binding|protein binding				0	Renal(35;0.156)					CAGGTCCTGCGGCTTCGAGTT	0.627			NA											3	19					0	0	0.000602	0	0
TBX22	50945	broad.mit.edu	37	X	79286464	79286464	+	Missense_Mutation	SNP	G	G	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chrX:79286464G>A	uc010nmg.1	+	9	1551	c.1417G>A	c.(1417-1419)GAC>AAC	p.D473N	TBX22_uc004edi.1_Missense_Mutation_p.D353N|TBX22_uc004edj.1_Missense_Mutation_p.D473N	NM_001109878	NP_001103348	Q9Y458	TBX22_HUMAN	T-box 22 isoform 1	473					multicellular organismal development|negative regulation of transcription from RNA polymerase II promoter	nucleus	DNA binding|sequence-specific DNA binding transcription factor activity			lung(7)|large_intestine(3)|central_nervous_system(2)|breast(1)|skin(1)|ovary(1)	15						TCCTTCCTATGACTTTTATAG	0.378			NA											12	101					0	0	0.013537	0	0
ZNF711	7552	broad.mit.edu	37	X	84526697	84526697	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chrX:84526697T>A	uc004eeo.2	+	9	2496	c.2149T>A	c.(2149-2151)TCT>ACT	p.S717T	ZNF711_uc004eep.2_Missense_Mutation_p.S717T|ZNF711_uc004eeq.2_Missense_Mutation_p.S763T|ZNF711_uc011mqy.1_Missense_Mutation_p.S316T	NM_021998	NP_068838	Q9Y462	ZN711_HUMAN	zinc finger protein 711	717	C2H2-type 11.				positive regulation of transcription, DNA-dependent|transcription, DNA-dependent	nucleus	protein binding|sequence-specific DNA binding|zinc ion binding			ovary(3)|skin(1)	4						TACAGATGCATCTGGCTTTAA	0.368			NA											18	130					0	0	0.008871	0	0
SYTL4	94121	broad.mit.edu	37	X	99942191	99942191	+	Missense_Mutation	SNP	T	T	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	T	T	-	-	T	T	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chrX:99942191T>A	uc004egd.3	-	13	1413	c.1057A>T	c.(1057-1059)AAC>TAC	p.N353Y	SYTL4_uc010nnb.2_Missense_Mutation_p.N25Y|SYTL4_uc010nnc.2_Missense_Mutation_p.N353Y|SYTL4_uc004ege.3_Missense_Mutation_p.N353Y|SYTL4_uc004egf.3_Missense_Mutation_p.N353Y|SYTL4_uc004egg.3_3'UTR	NM_080737	NP_542775	Q96C24	SYTL4_HUMAN	synaptotagmin-like 4	353					exocytosis|intracellular protein transport	extrinsic to membrane|plasma membrane|synaptic vesicle|transport vesicle membrane	neurexin binding|phospholipid binding|Rab GTPase binding|transporter activity|zinc ion binding			ovary(2)	2					Insulin Glargine recombinant(DB00047)|Insulin Lyspro recombinant(DB00046)|Insulin recombinant(DB00030)|Insulin, porcine(DB00071)	ACAAAGATGTTCCCGAAATCA	0.527			NA											11	69					0	0	0.001855	0	0
IL1RAPL2	26280	broad.mit.edu	37	X	105011610	105011610	+	Missense_Mutation	SNP	C	C	A			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chrX:105011610C>A	uc004elz.1	+	11	2773	c.2017C>A	c.(2017-2019)CCT>ACT	p.P673T		NM_017416	NP_059112	Q9NP60	IRPL2_HUMAN	interleukin 1 receptor accessory protein-like 2	673	Cytoplasmic (Potential).				central nervous system development|innate immune response	integral to membrane	interleukin-1, Type II, blocking receptor activity			breast(2)|ovary(1)	3						TTCTTTGCTGCCTTTATCCTC	0.403			NA											17	121					8.00594e-06	9.05217e-06	0.007413	1	0
MCF2	4168	broad.mit.edu	37	X	138708867	138708867	+	Missense_Mutation	SNP	G	G	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	G	G	-	-	G	G	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chrX:138708867G>T	uc004fau.2	-	5	781	c.487C>A	c.(487-489)CTG>ATG	p.L163M	MCF2_uc004fav.2_Missense_Mutation_p.L163M|MCF2_uc011mwl.1_Missense_Mutation_p.L124M|MCF2_uc010nsh.1_Missense_Mutation_p.L163M|MCF2_uc011mwm.1_Missense_Mutation_p.L124M|MCF2_uc011mwn.1_Missense_Mutation_p.L308M|MCF2_uc004faw.2_Missense_Mutation_p.L223M|MCF2_uc011mwo.1_Missense_Mutation_p.L223M	NM_005369	NP_005360	P10911	MCF2_HUMAN	MCF.2 cell line derived transforming sequence	163					apoptosis|induction of apoptosis by extracellular signals|nerve growth factor receptor signaling pathway|regulation of Rho protein signal transduction|small GTPase mediated signal transduction	cytoskeleton|cytosol|membrane|membrane fraction	protein binding|Rho guanyl-nucleotide exchange factor activity			lung(1)|pleura(1)	2	Acute lymphoblastic leukemia(192;0.000127)					GGCACTTCCAGATTTGTTAGC	0.383			NA											15	118					3.27435e-08	3.90177e-08	0.00245	1	0
GABRQ	55879	broad.mit.edu	37	X	151821213	151821213	+	Silent	SNP	C	C	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chrX:151821213C>T	uc004ffp.1	+	9	1388	c.1368C>T	c.(1366-1368)ACC>ACT	p.T456T		NM_018558	NP_061028	Q9UN88	GBRT_HUMAN	gamma-aminobutyric acid (GABA) receptor, theta	456						cell junction|chloride channel complex|integral to plasma membrane|postsynaptic membrane	chloride channel activity|extracellular ligand-gated ion channel activity|GABA-A receptor activity|neurotransmitter transporter activity			ovary(2)|pancreas(1)	3	Acute lymphoblastic leukemia(192;6.56e-05)					TCCCCTCCACCTCAGAGCAGG	0.592			NA											5	127					0	0	0.000602	0	0
GDI1	2664	broad.mit.edu	37	X	153668809	153668809	+	Missense_Mutation	SNP	A	A	T			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chrX:153668809A>T	uc004fli.3	+	6	1017	c.675A>T	c.(673-675)TTA>TTT	p.L225F	GDI1_uc011mzo.1_3'UTR|GDI1_uc004flj.2_5'Flank	NM_001493	NP_001484	P31150	GDIA_HUMAN	GDP dissociation inhibitor 1	225					protein transport|regulation of small GTPase mediated signal transduction|small GTPase mediated signal transduction	cytosol|midbody	GTPase activator activity|protein binding				0	all_cancers(53;5.05e-16)|all_epithelial(53;1.87e-10)|all_lung(58;1.84e-07)|Lung NSC(58;5.84e-07)|all_hematologic(71;2.45e-06)|Acute lymphoblastic leukemia(192;6.56e-05)|Breast(217;0.176)					GCCCATATTTATACCCGCTCT	0.567			NA											18	70					0	0	0.006122	0	0
OR2B11	127623	broad.mit.edu	37	1	247614375	247614375	+	Frame_Shift_Del	DEL	C	C	-			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr1:247614375delC	uc010pyx.1	-	1	910	c.910delG	c.(910-912)GCTfs	p.A304fs		NM_001004492	NP_001004492	Q5JQS5	OR2BB_HUMAN	olfactory receptor, family 2, subfamily B,	304	Cytoplasmic (Potential).				sensory perception of smell	integral to membrane|plasma membrane	olfactory receptor activity			upper_aerodigestive_tract(1)	1	all_cancers(71;4.51e-05)|all_epithelial(71;1.3e-05)|Breast(184;0.0149)|Ovarian(71;0.0377)|all_lung(81;0.0662)|Lung NSC(105;0.0724)	all_cancers(173;0.241)	OV - Ovarian serous cystadenocarcinoma(106;0.0188)			CTCCTCAGAGCCCCCTTCATA	0.458			NA											9	763	---	---	---	---	NA	NA	NA	NA	NA
NLRP14	338323	broad.mit.edu	37	11	7079029	7079029	+	Frame_Shift_Del	DEL	C	C	-			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	C	C	-	-	C	C	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr11:7079029delC	uc001mfb.1	+	7	2736	c.2413delC	c.(2413-2415)CTTfs	p.L805fs		NM_176822	NP_789792	Q86W24	NAL14_HUMAN	NLR family, pyrin domain containing 14	805	LRR 3.				cell differentiation|multicellular organismal development|spermatogenesis		ATP binding			ovary(3)|breast(2)|pancreas(1)|lung(1)|skin(1)	8				Epithelial(150;4.62e-08)|BRCA - Breast invasive adenocarcinoma(625;0.0871)		TGGAGTGCAGCTTTTGTGTGA	0.383			NA											24	210	---	---	---	---	NA	NA	NA	NA	NA
GCN1L1	10985	broad.mit.edu	37	12	120580382	120580383	+	Frame_Shift_Ins	INS	-	-	C			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr12:120580382_120580383insC	uc001txo.2	-	44	5770_5771	c.5757_5758insG	c.(5755-5760)TTGCGTfs	p.L1919fs		NM_006836	NP_006827	Q92616	GCN1L_HUMAN	GCN1 general control of amino-acid synthesis	1919_1920					regulation of translation	ribosome	protein binding|translation factor activity, nucleic acid binding			ovary(4)	4	all_neural(191;0.0804)|Medulloblastoma(191;0.0922)					AGGATCTCACGCAAGGTGCGGG	0.589			NA											22	77	---	---	---	---	NA	NA	NA	NA	NA
HNRNPC	3183	broad.mit.edu	37	14	21681149	21681161	+	Frame_Shift_Del	DEL	CACTCTTAGAATT	CACTCTTAGAATT	-			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	CACTCTTAGAATT	CACTCTTAGAATT	-	-	CACTCTTAGAATT	CACTCTTAGAATT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr14:21681149_21681161delCACTCTTAGAATT	uc001vzy.2	-	6	764_776	c.520_532delAATTCTAAGAGTG	c.(520-534)AATTCTAAGAGTGGAfs	p.N174fs	HNRNPC_uc001vzw.2_Frame_Shift_Del_p.N161fs|HNRNPC_uc001wad.2_Frame_Shift_Del_p.N94fs|HNRNPC_uc001vzx.2_Intron|HNRNPC_uc001vzz.2_Frame_Shift_Del_p.N161fs|HNRNPC_uc001waa.2_Frame_Shift_Del_p.N174fs|HNRNPC_uc010ail.2_Frame_Shift_Del_p.N174fs|HNRNPC_uc010tlq.1_RNA|HNRNPC_uc001wab.2_Frame_Shift_Del_p.N161fs|HNRNPC_uc001wac.2_Intron|HNRNPC_uc010tlr.1_Frame_Shift_Del_p.N39fs|HNRNPC_uc001waf.2_Frame_Shift_Del_p.N161fs|HNRNPC_uc001wae.2_Frame_Shift_Del_p.N161fs	NM_031314	NP_112604	P07910	HNRPC_HUMAN	heterogeneous nuclear ribonucleoprotein C	174_178						catalytic step 2 spliceosome|nucleoplasm	identical protein binding|nucleotide binding|RNA binding				0	all_cancers(95;0.00176)		Epithelial(56;1.08e-06)|all cancers(55;8.95e-06)	GBM - Glioblastoma multiforme(265;0.00783)		CCCCGCTGTCCACTCTTAGAATTGAAGCCACTT	0.455	NSCLC(108;607 2244 12726 38757)		NA											10	176	---	---	---	---	NA	NA	NA	NA	NA
NPHS1	4868	broad.mit.edu	37	19	36333449	36333451	+	In_Frame_Del	DEL	CTC	CTC	-			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	CTC	CTC	-	-	CTC	CTC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr19:36333449_36333451delCTC	uc002oby.2	-	18	2336_2338	c.2336_2338delGAG	c.(2335-2340)GGAGAA>GAA	p.G779del		NM_004646	NP_004637	O60500	NPHN_HUMAN	nephrin precursor	779	Ig-like C2-type 7.|Extracellular (Potential).				cell adhesion|excretion|muscle organ development	integral to plasma membrane		p.G779*(1)		ovary(4)|skin(1)	5	all_lung(56;7.14e-07)|Lung NSC(56;1.12e-06)|Esophageal squamous(110;0.162)		LUSC - Lung squamous cell carcinoma(66;0.0515)			TCCTCATCTTCTCCCTGGAGGCC	0.581			NA											20	133	---	---	---	---	NA	NA	NA	NA	NA
HIST1H4B	8366	broad.mit.edu	37	6	26027259	26027267	+	In_Frame_Del	DEL	CGTGTAGGT	CGTGTAGGT	-	rs139832518	byFrequency	TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	CGTGTAGGT	CGTGTAGGT	-	-	CGTGTAGGT	CGTGTAGGT	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr6:26027259_26027267delCGTGTAGGT	uc003nfr.2	-	1	214_222	c.214_222delACCTACACG	c.(214-222)ACCTACACGdel	p.TYT72del		NM_003544	NP_003535	P62805	H4_HUMAN	histone cluster 1, H4b	72_74					CenH3-containing nucleosome assembly at centromere|negative regulation of megakaryocyte differentiation|phosphatidylinositol-mediated signaling|telomere maintenance	nucleoplasm|nucleosome	DNA binding|protein binding			ovary(2)	2						TGGCGTGCTCCGTGTAGGTCACGGCGTCC	0.55			NA									OREG0017238	type=REGULATORY REGION|TFbs=CTCF|Dataset=CTCF ChIP-chip sites (Ren lab)|EvidenceSubtype=ChIP-on-chip (ChIP-chip)	20	120	---	---	---	---	NA	NA	NA	NA	NA
EGFR	1956	broad.mit.edu	37	7	55242465	55242479	+	In_Frame_Del	DEL	GGAATTAAGAGAAGC	GGAATTAAGAGAAGC	-	rs121913421		TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	GGAATTAAGAGAAGC	GGAATTAAGAGAAGC	-	-	GGAATTAAGAGAAGC	GGAATTAAGAGAAGC	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr7:55242465_55242479delGGAATTAAGAGAAGC	uc003tqk.2	+	19	2481_2495	c.2235_2249delGGAATTAAGAGAAGC	c.(2233-2250)AAGGAATTAAGAGAAGCA>AAA	p.ELREA746del	EGFR_uc010kzg.1_In_Frame_Del_p.ELREA701del|EGFR_uc011kco.1_In_Frame_Del_p.ELREA693del	NM_005228	NP_005219	P00533	EGFR_HUMAN	epidermal growth factor receptor isoform a	746_750	Cytoplasmic (Potential).|Protein kinase.		Missing (found in a lung cancer sample).		activation of phospholipase A2 activity by calcium-mediated signaling|activation of phospholipase C activity|axon guidance|cell proliferation|cell-cell adhesion|negative regulation of apoptosis|negative regulation of epidermal growth factor receptor signaling pathway|ossification|positive regulation of catenin import into nucleus|positive regulation of cell migration|positive regulation of cyclin-dependent protein kinase activity involved in G1/S|positive regulation of epithelial cell proliferation|positive regulation of MAP kinase activity|positive regulation of nitric oxide biosynthetic process|positive regulation of phosphorylation|positive regulation of protein kinase B signaling cascade|protein autophosphorylation|protein insertion into membrane|regulation of nitric-oxide synthase activity|regulation of peptidyl-tyrosine phosphorylation|response to stress|response to UV-A	basolateral plasma membrane|endoplasmic reticulum membrane|endosome|extracellular space|Golgi membrane|integral to membrane|nuclear membrane|Shc-EGFR complex	actin filament binding|ATP binding|double-stranded DNA binding|epidermal growth factor receptor activity|identical protein binding|MAP/ERK kinase kinase activity|protein heterodimerization activity|protein phosphatase binding|receptor signaling protein tyrosine kinase activity	p.E746_A750del(1613)|p.L747_P753>S(110)|p.L747_A750>P(74)|p.E746_S752>V(67)|p.L747_T751del(62)|p.E746_T751>A(30)|p.L747_S752del(28)|p.L747_T751>P(20)|p.E746_T751del(18)|p.L747_E749del(18)|p.K745_E749del(14)|p.E746_E749del(12)|p.E746_S752del(10)|p.L747_T751>S(7)|p.L747_P753>Q(7)|p.E746_P753>VS(6)|p.E746_A750>IP(5)|p.L747_T751>Q(5)|p.E746_T751>I(5)|p.E746_T751>V(5)|p.E746_S752>A(5)|p.E746_T751>IP(5)|p.E746_A750>QP(4)|p.E746V(4)|p.E746_S752>D(4)|p.K745_A750del(4)|p.L747S(3)|p.L747_S752>Q(3)|p.A750P(3)|p.E746_T751>VA(3)|p.E746_T751>VP(3)|p.E746_A750>RP(2)|p.E746_A750>S(2)|p.E746_S752>T(2)|p.A750_E758>P(2)|p.E746_T751>Q(2)|p.E746_T751>S(2)|p.E746_A750>DP(2)|p.E746_T751>L(2)|p.E746K(2)|p.E746_P753del(2)|p.E746_S752>I(2)|p.K745_E746insVPVAIK(2)|p.E746_A750>AP(2)|p.L747_K754>ST(1)|p.E746_A750>A(1)|p.E746_T751>P(1)|p.E746del(1)|p.A750_K754del(1)|p.L747_S752>QH(1)|p.L747P(1)|p.E746_A750>VP(1)|p.L747_K754>N(1)|p.L747_R748>FP(1)|p.K745_L747del(1)|p.L747_T751>A(1)|p.E746_P753>LS(1)|p.E746_P753>VQ(1)|p.E746_T751>LS(1)|p.A750_E758del(1)|p.E746_R748del(1)|p.I744_A750>VK(1)|p.E746I(1)|p.L747_K754del(1)|p.R748I(1)|p.E746_A750>KP(1)|p.E746_A750>EP(1)		lung(9213)|central_nervous_system(103)|stomach(41)|upper_aerodigestive_tract(39)|prostate(32)|ovary(31)|thyroid(24)|breast(11)|peritoneum(9)|oesophagus(9)|salivary_gland(9)|large_intestine(8)|kidney(8)|urinary_tract(6)|skin(5)|adrenal_gland(5)|soft_tissue(4)|bone(3)|NS(2)|pancreas(2)|haematopoietic_and_lymphoid_tissue(2)|thymus(2)|liver(2)|eye(1)	9571	all_cancers(1;1.57e-46)|all_epithelial(1;5.62e-37)|Lung NSC(1;9.29e-25)|all_lung(1;4.39e-23)|Esophageal squamous(2;7.55e-08)|Breast(14;0.0318)		GBM - Glioblastoma multiforme(1;0)|all cancers(1;2.19e-314)|Lung(13;4.65e-05)|LUSC - Lung squamous cell carcinoma(13;0.000168)|STAD - Stomach adenocarcinoma(5;0.00164)|Epithelial(13;0.0607)		Cetuximab(DB00002)|Erlotinib(DB00530)|Gefitinib(DB00317)|Lapatinib(DB01259)|Lidocaine(DB00281)|Panitumumab(DB01269)|Trastuzumab(DB00072)	TCGCTATCAAGGAATTAAGAGAAGCAACATCTCCG	0.479		E746_A750del(NCIH1650_LUNG)|E746K(HCC827_LUNG)|E746_A750del(PC14_LUNG)|L747_P753>Q(HCC4006_LUNG)	8	A|O|Mis		glioma|NSCLC	NSCLC			Lung_Cancer_Familial_Clustering_of	TCGA GBM(3;<1E-08)|TSP Lung(4;<1E-08)			31	85	---	---	---	---	NA	NA	NA	NA	NA
JHDM1D	80853	broad.mit.edu	37	7	139838949	139838949	+	Frame_Shift_Del	DEL	A	A	-			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr7:139838949delA	uc003vvm.2	-	2	240	c.236delT	c.(235-237)CTGfs	p.L79fs		NM_030647	NP_085150	Q6ZMT4	KDM7_HUMAN	jumonji C domain containing histone demethylase	79	PHD-type.				midbrain development|transcription, DNA-dependent	nucleolus	histone demethylase activity (H3-K27 specific)|histone demethylase activity (H3-K36 specific)|histone demethylase activity (H3-K9 specific)|histone demethylase activity (H4-K20 specific)|iron ion binding|methylated histone residue binding|oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen|zinc ion binding			ovary(1)	1	Melanoma(164;0.0142)					ACAGTGATACAGGTCAATGTC	0.353			NA											7	209	---	---	---	---	NA	NA	NA	NA	NA
ACO1	48	broad.mit.edu	37	9	32424665	32424666	+	Splice_Site	INS	-	-	AG			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	-	-	-	-	-	-	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr9:32424665_32424666insAG	uc003zqw.3	+	10	1343	c.1188_splice	c.e10+2	p.K396_splice	ACO1_uc010mjh.1_Splice_Site_p.K230_splice|ACO1_uc003zqx.3_Splice_Site_p.K396_splice|ACO1_uc003zqy.3_Splice_Site	NM_002197	NP_002188	P21399	ACOC_HUMAN	aconitase 1						citrate metabolic process|response to iron(II) ion|tricarboxylic acid cycle	cytosol|endoplasmic reticulum|Golgi apparatus	4 iron, 4 sulfur cluster binding|aconitate hydratase activity|citrate hydro-lyase (cis-aconitate-forming) activity|iron-responsive element binding|isocitrate hydro-lyase (cis-aconitate-forming) activity|metal ion binding|protein binding				0			LUSC - Lung squamous cell carcinoma(29;0.00813)	GBM - Glioblastoma multiforme(74;3.94e-06)		GGAGCCAAGGTAGGGGCCTGCG	0.515			NA											26	107	---	---	---	---	NA	NA	NA	NA	NA
AGPAT2	10555	broad.mit.edu	37	9	139571073	139571073	+	Frame_Shift_Del	DEL	A	A	-			TCGA-38-4628-01A-01D-1265-08	TCGA-38-4628-11A-01D-1265-08	A	A	-	-	A	A	Unknown	Untested	Somatic	Unspecified	WXS	none	NA	NA	Illumina HiSeq	67bc44b7-92cf-4e8f-a7f6-c53bf34a17c6	850c7f34-0d4a-4e8e-a9a3-c4563d4dcb04	g.chr9:139571073delA	uc004cii.1	-	4	654	c.552delT	c.(550-552)TTTfs	p.F184fs	AGPAT2_uc004cij.1_Intron	NM_006412	NP_006403	O15120	PLCB_HUMAN	1-acylglycerol-3-phosphate O-acyltransferase 2	184					phosphatidic acid biosynthetic process|positive regulation of cytokine production|triglyceride biosynthetic process	endoplasmic reticulum membrane|integral to membrane	1-acylglycerol-3-phosphate O-acyltransferase activity				0	all_cancers(76;0.0893)|all_epithelial(76;0.231)	Myeloproliferative disorder(178;0.0511)		OV - Ovarian serous cystadenocarcinoma(145;9.87e-06)|Epithelial(140;0.000123)		CGCCCTTCTTAAAAGGCAGCA	0.632			NA											26	102	---	---	---	---	NA	NA	NA	NA	NA
